miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-141-3p ABL1 -5.02396127982626 2.19224509139725e-24 1.32037015957096 1.87647767985755e-18 MirTarget -0.175107254317894 1.9871253927784e-40 NA NA NA hsa-miR-141-3p ABL2 -5.02396127982626 2.19224509139725e-24 0.318835189302922 0.0455399452105164 MirTarget;TargetScan;miRNATAP -0.134399536040292 8.02666476133273e-22 NA NA NA hsa-miR-141-3p ACO1 -5.02396127982626 2.19224509139725e-24 0.652500844012164 0.000553364482031016 MirTarget;TargetScan -0.130163835782654 1.98192362231869e-14 NA NA NA hsa-miR-141-3p ADARB1 -5.02396127982626 2.19224509139725e-24 1.92780468757935 3.75403498492544e-10 MirTarget -0.338475785952679 4.09008976936958e-37 NA NA NA hsa-miR-141-3p AFAP1 -5.02396127982626 2.19224509139725e-24 0.984844531728041 0.000121375966999108 mirMAP -0.240690375927166 6.02043219001966e-27 NA NA NA hsa-miR-141-3p AKAP2 -5.02396127982626 2.19224509139725e-24 2.50607126147978 8.18180385648383e-05 TargetScan -0.592451456526002 2.32091834867608e-26 NA NA NA hsa-miR-141-3p AMOTL1 -5.02396127982626 2.19224509139725e-24 1.62373117026862 1.24108045740127e-08 TargetScan -0.263915992858439 1.62622341145465e-25 NA NA NA hsa-miR-141-3p AMZ1 -5.02396127982626 2.19224509139725e-24 -0.478054987094893 0.336377469860165 mirMAP -0.170552638793477 0.000193440516792394 NA NA NA hsa-miR-141-3p ANGPTL1 -5.02396127982626 2.19224509139725e-24 4.51343158742721 1.32318310475564e-13 MirTarget -0.761705592149959 2.2939308448729e-49 NA NA NA hsa-miR-141-3p ANK2 -5.02396127982626 2.19224509139725e-24 4.31721795702785 2.30783903904995e-14 TargetScan;miRNATAP -0.683679141640631 3.18446904488388e-45 NA NA NA hsa-miR-141-3p ANKRD44 -5.02396127982626 2.19224509139725e-24 1.93020763162674 4.46055534768925e-08 TargetScan -0.345297858061492 7.15806905996816e-29 NA NA NA hsa-miR-141-3p ANO5 -5.02396127982626 2.19224509139725e-24 3.19214261632059 9.9201493859798e-09 mirMAP -0.298421469653444 7.41246753821778e-09 NA NA NA hsa-miR-141-3p APBB2 -5.02396127982626 2.19224509139725e-24 0.590550070945143 0.00139703077075367 MirTarget;TargetScan -0.16820450447715 2.14901507304753e-25 NA NA NA hsa-miR-141-3p APOLD1 -5.02396127982626 2.19224509139725e-24 2.61565377645349 1.36771501780794e-19 TargetScan -0.243706988784122 8.0918207579202e-20 NA NA NA hsa-miR-141-3p ARHGAP24 -5.02396127982626 2.19224509139725e-24 2.02152097141819 3.81745641239796e-10 TargetScan;miRNATAP -0.384112170664898 9.24234006817553e-45 NA NA NA hsa-miR-141-3p ARID5B -5.02396127982626 2.19224509139725e-24 1.57471227678776 1.38880293146976e-13 TargetScan;miRNATAP -0.163570235555056 5.51748671636683e-17 NA NA NA hsa-miR-141-3p ARL10 -5.02396127982626 2.19224509139725e-24 1.12227531152641 0.00197533796722557 mirMAP -0.254180203960422 6.73994516307074e-15 NA NA NA hsa-miR-141-3p ARL4A -5.02396127982626 2.19224509139725e-24 0.615829174715151 0.0152477484975193 TargetScan -0.102434904962628 1.12328062913009e-05 NA NA NA hsa-miR-141-3p ARNT2 -5.02396127982626 2.19224509139725e-24 1.45137144640546 0.000194389722909982 mirMAP -0.133475560455107 0.000218811297212122 NA NA NA hsa-miR-141-3p ARNTL -5.02396127982626 2.19224509139725e-24 0.356733668497137 0.0895626680520647 MirTarget;TargetScan;miRNATAP -0.10408450992134 5.45135927978183e-08 NA NA NA hsa-miR-141-3p ASB1 -5.02396127982626 2.19224509139725e-24 0.870009811365471 1.63208206880825e-08 mirMAP -0.120167852143178 4.97494070976464e-18 NA NA NA hsa-miR-141-3p ASTN1 -5.02396127982626 2.19224509139725e-24 2.34091357321142 2.35607881846948e-05 MirTarget;miRNATAP -0.142422591927457 0.0058243112113976 NA NA NA hsa-miR-141-3p ASXL3 -5.02396127982626 2.19224509139725e-24 3.33764959592997 4.422152746114e-10 TargetScan -0.310308010322806 3.94264179759946e-10 NA NA NA hsa-miR-141-3p ATP8A1 -5.02396127982626 2.19224509139725e-24 1.47752118217688 7.63290299845146e-05 MirTarget;TargetScan -0.155539937806406 6.64664107398294e-06 NA NA NA hsa-miR-141-3p ATXN1 -5.02396127982626 2.19224509139725e-24 1.5104377454496 2.95939614593368e-08 MirTarget;TargetScan;miRNATAP -0.242034345827017 1.89337327751857e-23 NA NA NA hsa-miR-141-3p BACE1 -5.02396127982626 2.19224509139725e-24 0.723461241968304 0.000957929388935248 TargetScan;miRNATAP -0.219980230813457 2.13236282870747e-31 NA NA NA hsa-miR-141-3p BACH2 -5.02396127982626 2.19224509139725e-24 1.52271748612635 0.00133867288726185 TargetScan -0.485520358400061 1.24233512861177e-32 NA NA NA hsa-miR-210-3p BDNF -6.07079758655679 2.22120227133377e-28 2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.237223359082858 5.07246234320821e-11 NA NA NA hsa-miR-141-3p BEND4 -5.02396127982626 2.19224509139725e-24 1.96898871811516 7.2885725348349e-05 TargetScan;miRNATAP -0.289863184708252 1.6418670625527e-10 NA NA NA hsa-miR-141-3p BNC2 -5.02396127982626 2.19224509139725e-24 2.95176911794991 3.4601480240003e-09 TargetScan -0.634996328559649 3.99693205136847e-53 NA NA NA hsa-miR-141-3p BVES -5.02396127982626 2.19224509139725e-24 2.76011138905276 3.72014251471109e-09 mirMAP -0.482117813782504 4.24689671402245e-32 NA NA NA hsa-miR-141-3p C11orf21 -5.02396127982626 2.19224509139725e-24 1.30848301714895 0.00226870309084663 mirMAP -0.239688766014697 8.64099216632011e-10 NA NA NA hsa-miR-141-3p CACNA2D1 -5.02396127982626 2.19224509139725e-24 3.31556565717047 8.68804644381516e-07 TargetScan -0.712756989651708 1.52663401986901e-34 NA NA NA hsa-miR-141-3p CADM1 -5.02396127982626 2.19224509139725e-24 1.1928516537365 0.012512532603774 MirTarget;TargetScan -0.158377342012299 0.000330308063762073 NA NA NA hsa-miR-141-3p CADM2 -5.02396127982626 2.19224509139725e-24 3.83563052563186 2.24615008924082e-11 TargetScan;miRNATAP -0.296449332510535 3.20564005327105e-08 NA NA NA hsa-miR-141-3p CALU -5.02396127982626 2.19224509139725e-24 0.14810020107485 0.463184247628695 TargetScan -0.195681214306377 1.90065013398411e-29 NA NA NA hsa-miR-141-3p CAMK4 -5.02396127982626 2.19224509139725e-24 1.28087531958322 0.00219906979140793 mirMAP -0.286889492770795 2.7215319426945e-14 NA NA NA hsa-miR-141-3p CCDC80 -5.02396127982626 2.19224509139725e-24 3.33072052510427 2.4668324543934e-10 MirTarget;TargetScan -0.693632636221427 5.46323443396302e-58 NA NA NA hsa-miR-141-3p CCND2 -5.02396127982626 2.19224509139725e-24 2.42747067684237 2.06814828958879e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-141-3p CCPG1 -5.02396127982626 2.19224509139725e-24 1.00054342022822 9.3580494318349e-08 MirTarget;miRNATAP -0.187963297470156 1.21508136995256e-30 NA NA NA hsa-miR-141-3p CD274 -5.02396127982626 2.19224509139725e-24 -0.0610119269874345 0.904540846938381 MirTarget -0.219387383135692 2.45166085997734e-06 NA NA NA hsa-miR-141-3p CD59 -5.02396127982626 2.19224509139725e-24 0.701153559236413 0.00130409241528679 mirMAP -0.104731717796861 1.60748972337276e-07 NA NA NA hsa-miR-141-3p CDC25B -5.02396127982626 2.19224509139725e-24 -0.783166040527923 0.00478680511554004 TargetScan -0.118085231335799 3.69707768792997e-06 NA NA NA hsa-miR-141-3p CDC42EP3 -5.02396127982626 2.19224509139725e-24 1.35474123311743 4.46611463922144e-07 MirTarget;TargetScan -0.222656011819807 1.75742899844836e-20 NA NA NA hsa-miR-141-3p CDK6 -5.02396127982626 2.19224509139725e-24 0.774202349805119 0.064787030605636 TargetScan;miRNATAP -0.280860480145549 9.29496321423746e-14 NA NA NA hsa-miR-141-3p CDON -5.02396127982626 2.19224509139725e-24 2.61239140080419 3.20760880328892e-10 TargetScan;miRNATAP -0.399651490992396 1.87667057546839e-27 NA NA NA hsa-miR-141-3p CDV3 -5.02396127982626 2.19224509139725e-24 0.422762901340261 0.00210317952393326 TargetScan;miRNATAP -0.108062710883357 7.65468940912447e-19 NA NA NA hsa-miR-141-3p CELF2 -5.02396127982626 2.19224509139725e-24 3.04719737979328 4.72041352009215e-15 mirMAP;miRNATAP -0.468029455067076 1.44353494732578e-44 NA NA NA hsa-miR-141-3p CEP170 -5.02396127982626 2.19224509139725e-24 0.105046872769038 0.582677978132974 TargetScan -0.143778949230595 2.34588339926208e-17 NA NA NA hsa-miR-141-3p CFL2 -5.02396127982626 2.19224509139725e-24 2.61712932503392 6.68766729849374e-21 TargetScan -0.423079946720063 4.08147779181854e-80 NA NA NA hsa-miR-141-3p CHRDL1 -5.02396127982626 2.19224509139725e-24 6.14628787036669 1.26356425887684e-13 MirTarget;TargetScan -0.900396235275418 3.3629060237609e-35 NA NA NA hsa-miR-141-3p CLIC4 -5.02396127982626 2.19224509139725e-24 1.72389310060141 6.21382968572491e-08 MirTarget -0.404726937144751 1.2775065112373e-53 NA NA NA hsa-miR-141-3p CLIP2 -5.02396127982626 2.19224509139725e-24 0.796927760614636 0.00157984633892106 MirTarget;TargetScan -0.153053376466775 2.28983610764706e-11 NA NA NA hsa-miR-141-3p CNTN1 -5.02396127982626 2.19224509139725e-24 4.98280431564283 1.02293078354206e-09 MirTarget;TargetScan;miRNATAP -0.748169609710896 8.29284114896725e-25 NA NA NA hsa-miR-141-3p COL11A1 -5.02396127982626 2.19224509139725e-24 -4.68886927590747 2.15659824797735e-08 miRNATAP -0.226787669474765 0.00396629375366405 NA NA NA hsa-miR-141-3p COL15A1 -5.02396127982626 2.19224509139725e-24 0.944640457730359 0.00987813769171885 MirTarget -0.340716901256044 1.20518963821043e-26 NA NA NA hsa-miR-141-3p COL8A1 -5.02396127982626 2.19224509139725e-24 0.750287440568718 0.115004485468589 mirMAP -0.3753845013992 5.90933384363944e-19 NA NA NA hsa-miR-141-3p CORO1C -5.02396127982626 2.19224509139725e-24 1.12142787999648 2.05016310243195e-07 TargetScan -0.247770057122117 7.60999610194092e-42 NA NA NA hsa-miR-210-3p CORO2B -6.07079758655679 2.22120227133377e-28 2.02918310395295 2.78730592488675e-06 MirTarget -0.21933845970618 5.15126217245718e-10 NA NA NA hsa-miR-141-3p CPEB4 -5.02396127982626 2.19224509139725e-24 1.56126787942281 1.72557073170316e-13 TargetScan -0.12354401076053 4.29390485758248e-10 NA NA NA hsa-miR-141-3p CREB5 -5.02396127982626 2.19224509139725e-24 2.27679484644664 4.56595042875634e-09 mirMAP -0.412602227752003 1.82008564281382e-34 NA NA NA hsa-miR-141-3p CRMP1 -5.02396127982626 2.19224509139725e-24 1.10713929622082 0.00157678184529983 MirTarget;TargetScan -0.225882860206249 1.04462945549287e-12 NA NA NA hsa-miR-141-3p CSF3 -5.02396127982626 2.19224509139725e-24 4.55276205983688 3.03447416692714e-08 TargetScan;miRNATAP -0.537552891809218 9.56020415551903e-13 NA NA NA hsa-miR-141-3p CTSB -5.02396127982626 2.19224509139725e-24 -0.103494529069309 0.676734042160379 mirMAP -0.17150568102485 1.12551008947305e-14 NA NA NA hsa-miR-141-3p CTTNBP2 -5.02396127982626 2.19224509139725e-24 2.89596279474146 5.90459907376795e-06 miRNATAP -0.236598863986591 6.89302999060296e-05 NA NA NA hsa-miR-141-3p CXCL12 -5.02396127982626 2.19224509139725e-24 3.25514460573679 2.71023256513871e-11 miRNATAP -0.581600485846245 1.98789449461909e-44 NA NA NA hsa-miR-141-3p CYLD -5.02396127982626 2.19224509139725e-24 0.8929274935414 1.56901081849431e-07 mirMAP -0.139718374493641 4.72424398005685e-20 NA NA NA hsa-miR-141-3p CYP26B1 -5.02396127982626 2.19224509139725e-24 0.687056430058883 0.15191405383577 MirTarget;TargetScan;miRNATAP -0.379672308940082 4.02732278327878e-19 NA NA NA hsa-miR-141-3p DIO2 -5.02396127982626 2.19224509139725e-24 0.242509194085751 0.634536833282091 miRNATAP -0.293892171655239 1.99637530606769e-10 NA NA NA hsa-miR-141-3p DLC1 -5.02396127982626 2.19224509139725e-24 1.80446027708783 9.14505487509162e-10 TargetScan;miRNATAP -0.205743446999626 2.40423756136419e-14 26278151 MicroRNA 141 regulates the tumour suppressor DLC1 in colorectal cancer; Luciferase reporter assays and Western blots showed that DLC1 was a direct target of miR-141 in CRC; The expression levels of miR-141 were obviously up-regulated in CRC tissues compared to non-cancerous tissues while DLC1 expression levels were down-regulated in a high proportion of clinical samples 14/18; In addition correlation analyses revealed negative correlation between miR-141 levels and DLC1 expression levels in CRC tissues; In conclusion we demonstrated that miR-141 is up-regulated in CRC and acts as a functional oncogene by targeting DLC1 colorectal cancer hsa-miR-141-3p DOCK4 -5.02396127982626 2.19224509139725e-24 0.482456191440432 0.0791191956674344 MirTarget;TargetScan -0.182121730425507 1.6735288026444e-13 NA NA NA hsa-miR-141-3p DPYSL3 -5.02396127982626 2.19224509139725e-24 2.3174606683978 1.31913973979469e-07 TargetScan -0.538946381354509 4.38482185108261e-49 NA NA NA hsa-miR-141-3p DSEL -5.02396127982626 2.19224509139725e-24 1.79437646323741 2.08106957836489e-07 TargetScan -0.293103774207814 2.27712643948802e-21 NA NA NA hsa-miR-141-3p DST -5.02396127982626 2.19224509139725e-24 1.11542714896545 9.14769438027736e-05 mirMAP -0.122503310762156 3.24347958325919e-06 NA NA NA hsa-miR-141-3p DUSP1 -5.02396127982626 2.19224509139725e-24 3.47418646928724 1.98436002754553e-20 TargetScan -0.341619784247028 4.31538999884695e-23 NA NA NA hsa-miR-141-3p DUSP3 -5.02396127982626 2.19224509139725e-24 1.04472877082382 6.16231013810303e-12 MirTarget;TargetScan;miRNATAP -0.153679233077013 1.48438763140924e-30 NA NA NA hsa-miR-141-3p DYNC1I1 -5.02396127982626 2.19224509139725e-24 2.0457299899893 0.000100882779278429 MirTarget -0.213104292318958 1.19223595981888e-05 NA NA NA hsa-miR-141-3p DZIP1 -5.02396127982626 2.19224509139725e-24 1.57008196403815 1.84356720275658e-05 TargetScan;miRNATAP -0.293961254371322 2.97515506435194e-19 NA NA NA hsa-miR-141-3p EGR2 -5.02396127982626 2.19224509139725e-24 2.81415398238775 4.48213127682578e-11 TargetScan;miRNATAP -0.469632063005659 7.87492781791156e-37 NA NA NA hsa-miR-210-3p ELFN2 -6.07079758655679 2.22120227133377e-28 0.555776982736758 0.366123227740696 MirTarget -0.169371259234315 0.000762086167416835 NA NA NA hsa-miR-141-3p ELK3 -5.02396127982626 2.19224509139725e-24 0.313611617704992 0.256409444995648 TargetScan -0.186479252851037 5.30229855466226e-14 NA NA NA hsa-miR-141-3p ELL2 -5.02396127982626 2.19224509139725e-24 1.08408930026814 1.1824061831145e-05 TargetScan -0.132345567602773 5.72819500490292e-09 NA NA NA hsa-miR-141-3p ENAH -5.02396127982626 2.19224509139725e-24 0.681669392071857 0.000630502361017477 TargetScan -0.149654623473878 4.805902500454e-17 NA NA NA hsa-miR-141-3p EPB41L3 -5.02396127982626 2.19224509139725e-24 1.63344198757467 7.20507965391257e-05 miRNATAP -0.292529346530813 3.31274956469315e-15 NA NA NA hsa-miR-141-3p EPHA7 -5.02396127982626 2.19224509139725e-24 4.20206952913252 6.81894380739864e-12 TargetScan;miRNATAP -0.330815924436256 7.49589080274753e-09 26261572 Among those the expression of EPHA7 and PI15 were negatively correlated with that of microRNA-141 and they were also identified as potential targets of this microRNA via microRNA-mRNA interaction; We thus concluded that microRNA-141 EPHA7 and PI15 might jointly participate in the regulation of drug resistance in ovarian cancer and serve as potential targets in targeted therapies drug resistance ovarian cancer hsa-miR-141-3p ERC2 -5.02396127982626 2.19224509139725e-24 0.0824641536555684 0.866171635880601 MirTarget;TargetScan -0.105782107218275 0.0193358207021086 NA NA NA hsa-miR-141-3p ERG -5.02396127982626 2.19224509139725e-24 1.3479378771967 2.23511589174119e-07 MirTarget;TargetScan -0.253013233433548 1.37986124332074e-28 NA NA NA hsa-miR-141-3p ETS1 -5.02396127982626 2.19224509139725e-24 0.699528618233349 0.00228038287696188 mirMAP -0.136403222013607 5.63450066135883e-11 NA NA NA hsa-miR-141-3p FAM133A -5.02396127982626 2.19224509139725e-24 0.536633813285276 0.494531763298326 mirMAP -0.314537291307707 1.27130797078722e-05 NA NA NA hsa-miR-141-3p FAM167A -5.02396127982626 2.19224509139725e-24 -0.270294509636431 0.487790761066615 mirMAP -0.19322302650933 5.23365663962573e-08 NA NA NA hsa-miR-141-3p FAM168A -5.02396127982626 2.19224509139725e-24 0.715878355157019 0.00480870625343387 TargetScan -0.170237723829022 9.85489573786363e-14 NA NA NA hsa-miR-141-3p FAM168B -5.02396127982626 2.19224509139725e-24 0.9465480741702 2.76446564795563e-10 MirTarget;TargetScan -0.108770444818815 1.75199417266574e-15 NA NA NA hsa-miR-141-3p FAM20C -5.02396127982626 2.19224509139725e-24 1.33283956490135 0.0018135829325117 MirTarget -0.462532522787813 3.40051627730541e-37 NA NA NA hsa-miR-141-3p FAM26E -5.02396127982626 2.19224509139725e-24 1.51380317009881 3.60338715627855e-05 mirMAP -0.406365683654429 5.41026450908213e-39 NA NA NA hsa-miR-141-3p FAM46C -5.02396127982626 2.19224509139725e-24 1.66367766872796 7.82547314993559e-08 TargetScan;miRNATAP -0.106435921017189 0.0002379062668133 NA NA NA hsa-miR-141-3p FAT3 -5.02396127982626 2.19224509139725e-24 2.79096679677475 3.4034386744821e-06 MirTarget;miRNATAP -0.243303201500778 1.29983926491812e-05 NA NA NA hsa-miR-141-3p FER -5.02396127982626 2.19224509139725e-24 0.960481943610694 0.00017463846349353 mirMAP -0.182765281232224 2.13399687007402e-15 NA NA NA hsa-miR-141-3p FGF13 -5.02396127982626 2.19224509139725e-24 2.79657067303141 1.56359356599715e-14 TargetScan -0.302898746415501 8.87758287571865e-20 NA NA NA hsa-miR-141-3p FKBP5 -5.02396127982626 2.19224509139725e-24 1.54368679613988 4.05564573895976e-05 TargetScan -0.388803729060971 3.70334274744257e-33 NA NA NA hsa-miR-141-3p FLI1 -5.02396127982626 2.19224509139725e-24 1.10881984531465 6.56713737767829e-05 TargetScan -0.284561790021729 1.4696047688211e-32 NA NA NA hsa-miR-141-3p FNIP2 -5.02396127982626 2.19224509139725e-24 0.757876478794657 0.0104512107248218 TargetScan -0.15293019658296 1.51005751533022e-08 NA NA NA hsa-miR-141-3p FOXN3 -5.02396127982626 2.19224509139725e-24 1.43525991184281 2.70084540955355e-16 MirTarget;TargetScan;miRNATAP -0.144244534851771 3.13744918937603e-19 NA NA NA hsa-miR-141-3p FOXP2 -5.02396127982626 2.19224509139725e-24 3.99353205302265 7.5817096232968e-11 TargetScan -0.492242020268146 1.02220254321097e-18 NA NA NA hsa-miR-141-3p FRMD6 -5.02396127982626 2.19224509139725e-24 0.932146068496432 0.00182819765018773 MirTarget;TargetScan;miRNATAP -0.116995591435815 2.21065057353424e-05 NA NA NA hsa-miR-141-3p FSD1L -5.02396127982626 2.19224509139725e-24 0.147593029414251 0.718548814950207 TargetScan -0.293153485317503 1.08240803873113e-15 NA NA NA hsa-miR-141-3p FTO -5.02396127982626 2.19224509139725e-24 0.52176349689637 9.56066637934305e-05 mirMAP -0.103295701715657 4.48104012531606e-18 NA NA NA hsa-miR-141-3p FYCO1 -5.02396127982626 2.19224509139725e-24 1.62261005933921 1.0187113078264e-16 mirMAP -0.119610814609639 7.37134797454179e-11 NA NA NA hsa-miR-141-3p FZD4 -5.02396127982626 2.19224509139725e-24 0.828422580378943 0.000677699890493144 TargetScan -0.113168852885507 4.32145832906429e-07 NA NA NA hsa-miR-141-3p GAB2 -5.02396127982626 2.19224509139725e-24 1.20165054399091 1.06247685933266e-06 mirMAP -0.132797466896447 4.66744464034186e-09 NA NA NA hsa-miR-141-3p GATA6 -5.02396127982626 2.19224509139725e-24 3.38076408789276 2.92272151179451e-14 TargetScan;miRNATAP -0.506838016893668 2.69884556190457e-39 NA NA NA hsa-miR-141-3p GCNT2 -5.02396127982626 2.19224509139725e-24 0.712162617542869 0.0826580493563989 TargetScan -0.111158126943812 0.00337209235210958 NA NA NA hsa-miR-141-3p GDF6 -5.02396127982626 2.19224509139725e-24 1.13505992050111 0.0279057480958108 TargetScan -0.341173884857515 2.2217799210351e-13 NA NA NA hsa-miR-141-3p GEM -5.02396127982626 2.19224509139725e-24 3.69134770515528 5.61525969896728e-16 MirTarget -0.587565485490449 1.27714231653948e-52 NA NA NA hsa-miR-141-3p GFRA1 -5.02396127982626 2.19224509139725e-24 4.99535302188274 6.14065741523e-16 mirMAP -0.393365060968066 1.10917039753486e-11 NA NA NA hsa-miR-141-3p GFRA2 -5.02396127982626 2.19224509139725e-24 3.21725146250063 1.33382900263128e-15 mirMAP -0.444794470460335 2.93223082155244e-36 NA NA NA hsa-miR-141-3p GJC1 -5.02396127982626 2.19224509139725e-24 0.972020676723746 0.00222017431601352 MirTarget;TargetScan;miRNATAP -0.25162506617731 5.57057070933156e-19 NA NA NA hsa-miR-141-3p GLI2 -5.02396127982626 2.19224509139725e-24 2.28902662613598 1.96789417911739e-06 MirTarget -0.490600186796826 7.08521741863515e-32 NA NA NA hsa-miR-141-3p GLRX -5.02396127982626 2.19224509139725e-24 0.275147826859437 0.316770480646161 MirTarget;TargetScan;miRNATAP -0.133787914261733 9.284256458484e-08 NA NA NA hsa-miR-141-3p GNA12 -5.02396127982626 2.19224509139725e-24 0.327866213861201 0.0839906551813209 mirMAP -0.159733729112464 9.55959524392438e-22 NA NA NA hsa-miR-141-3p GNE -5.02396127982626 2.19224509139725e-24 0.892555191707628 0.00298922209935843 MirTarget -0.129102780931227 3.01283936788047e-06 NA NA NA hsa-miR-141-3p GNG4 -5.02396127982626 2.19224509139725e-24 -0.216159437363437 0.744682539041036 mirMAP -0.31409320803834 2.17335380219881e-07 NA NA NA hsa-miR-141-3p GNG7 -5.02396127982626 2.19224509139725e-24 3.47904747202308 1.8399053265995e-21 MirTarget;TargetScan;miRNATAP -0.30384219654589 5.18426669901378e-19 NA NA NA hsa-miR-141-3p GPC6 -5.02396127982626 2.19224509139725e-24 2.70666453497929 7.48358520640856e-07 TargetScan -0.642273653881201 3.28967946680011e-44 NA NA NA hsa-miR-141-3p GPD1 -5.02396127982626 2.19224509139725e-24 1.45048771597392 0.00525960664850103 TargetScan -0.193297434147106 5.55590553635821e-05 NA NA NA hsa-miR-141-3p GPM6B -5.02396127982626 2.19224509139725e-24 2.38616048413304 8.19968989398376e-13 TargetScan;miRNATAP -0.297794469902579 4.04873608589634e-23 NA NA NA hsa-miR-141-3p GPR174 -5.02396127982626 2.19224509139725e-24 0.709153603867135 0.15454442855266 TargetScan -0.28228130170386 4.20449049957377e-10 NA NA NA hsa-miR-141-3p GPR63 -5.02396127982626 2.19224509139725e-24 0.916305216112566 0.0143681611862449 TargetScan -0.152935149429126 8.84758404382338e-06 NA NA NA hsa-miR-141-3p GPRC5B -5.02396127982626 2.19224509139725e-24 0.92103982223247 0.00842835686969578 mirMAP -0.171082278386794 8.92862761745291e-08 NA NA NA hsa-miR-141-3p GRAP2 -5.02396127982626 2.19224509139725e-24 1.99328764327358 4.55220376112543e-06 mirMAP -0.340788701134229 2.53690358789535e-18 NA NA NA hsa-miR-141-3p GRIK3 -5.02396127982626 2.19224509139725e-24 4.42199547952411 9.71715591269951e-16 mirMAP -0.341467034564714 3.89334996772762e-11 NA NA NA hsa-miR-141-3p GRIN3A -5.02396127982626 2.19224509139725e-24 0.237867214305964 0.4031881206478 TargetScan;miRNATAP -0.189882395288036 1.03259609480364e-13 NA NA NA hsa-miR-141-3p GSN -5.02396127982626 2.19224509139725e-24 2.39108746525379 5.58907404692464e-22 MirTarget -0.263776531040741 4.84764945367784e-32 NA NA NA hsa-miR-141-3p HAS2 -5.02396127982626 2.19224509139725e-24 1.4533402537015 0.00631123295868362 MirTarget -0.365296908517968 2.41269196709147e-14 NA NA NA hsa-miR-141-3p HDAC4 -5.02396127982626 2.19224509139725e-24 1.80036091395253 1.96398022917234e-18 TargetScan;miRNATAP -0.224498344325949 7.77378690757405e-35 NA NA NA hsa-miR-141-3p HECW1 -5.02396127982626 2.19224509139725e-24 -0.0775842383611332 0.876990656803427 TargetScan -0.232466652099627 3.80438164884885e-07 NA NA NA hsa-miR-141-3p HEYL -5.02396127982626 2.19224509139725e-24 0.309360248202531 0.275918394616269 mirMAP -0.213270840967025 3.00765131550456e-17 NA NA NA hsa-miR-141-3p HGF -5.02396127982626 2.19224509139725e-24 2.96833708580794 2.21214820634195e-07 MirTarget;TargetScan -0.676636907580645 1.12497659260577e-44 NA NA NA hsa-miR-141-3p HIPK3 -5.02396127982626 2.19224509139725e-24 1.74508965708073 2.92750932105638e-06 MirTarget;TargetScan -0.221123587925148 9.98617371242522e-11 NA NA NA hsa-miR-141-3p HIVEP3 -5.02396127982626 2.19224509139725e-24 -0.0288071997334836 0.920325184162581 mirMAP -0.174760553143419 1.75045749365667e-11 NA NA NA hsa-miR-141-3p HLF -5.02396127982626 2.19224509139725e-24 5.48181644757567 4.24267397704754e-28 TargetScan -0.59042899505983 1.76085178870284e-39 NA NA NA hsa-miR-141-3p HOXA11 -5.02396127982626 2.19224509139725e-24 0.779286751498242 0.0292176238744172 TargetScan;miRNATAP -0.123667292408771 0.000174087134451521 NA NA NA hsa-miR-141-3p HS3ST3B1 -5.02396127982626 2.19224509139725e-24 0.639453810462204 0.183372048335564 mirMAP -0.382910834502429 2.28072861709081e-19 NA NA NA hsa-miR-141-3p HSPA13 -5.02396127982626 2.19224509139725e-24 0.287922247159855 0.106347732939111 TargetScan -0.133647269763646 3.30479934756916e-17 NA NA NA hsa-miR-141-3p IFFO2 -5.02396127982626 2.19224509139725e-24 0.910440393472387 0.00201393161780148 MirTarget;TargetScan -0.101515155443113 0.000194771695236261 NA NA NA hsa-miR-141-3p IGDCC4 -5.02396127982626 2.19224509139725e-24 1.98591119557307 4.45190548749856e-08 TargetScan;miRNATAP -0.350675967176301 4.59141518716107e-28 NA NA NA hsa-miR-141-3p IGF2BP2 -5.02396127982626 2.19224509139725e-24 -0.953732727730338 0.144541577214547 MirTarget;TargetScan;miRNATAP -0.30821004751603 2.48916654507274e-07 NA NA NA hsa-miR-141-3p IGSF6 -5.02396127982626 2.19224509139725e-24 -0.285339839382025 0.483514527935796 TargetScan -0.261703720411169 9.3016910892664e-13 NA NA NA hsa-miR-141-3p IGSF9B -5.02396127982626 2.19224509139725e-24 3.70052179046043 2.07484176922389e-13 TargetScan -0.381073867495267 2.00085566827593e-16 NA NA NA hsa-miR-141-3p IL18R1 -5.02396127982626 2.19224509139725e-24 0.493217737310221 0.124639520069654 MirTarget -0.133638408696018 5.67399116458649e-06 NA NA NA hsa-miR-141-3p IL6R -5.02396127982626 2.19224509139725e-24 1.86576803083567 2.67166891084768e-06 MirTarget -0.23775486835915 6.49333048566365e-11 NA NA NA hsa-miR-141-3p IRAK3 -5.02396127982626 2.19224509139725e-24 1.61324599744624 9.44362061411799e-07 mirMAP -0.237412262860539 1.63026403262395e-15 NA NA NA hsa-miR-141-3p IRS2 -5.02396127982626 2.19224509139725e-24 0.91132441213611 0.0110242467169191 MirTarget;TargetScan;miRNATAP -0.156621642072101 1.95203993217853e-06 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2 metastasis thyroid cancer hsa-miR-141-3p ITGAV -5.02396127982626 2.19224509139725e-24 0.0552493406333667 0.795714969238088 MirTarget -0.125634945314397 7.01655633438231e-11 NA NA NA hsa-miR-141-3p ITSN1 -5.02396127982626 2.19224509139725e-24 0.611059124760149 8.82737803628764e-05 TargetScan;mirMAP -0.102708277571066 3.091769116372e-13 NA NA NA hsa-miR-141-3p JAZF1 -5.02396127982626 2.19224509139725e-24 1.91995536790338 5.72076669427936e-12 MirTarget;miRNATAP -0.376797677136439 1.81571796311472e-61 NA NA NA hsa-miR-141-3p JUN -5.02396127982626 2.19224509139725e-24 2.04611084807692 9.15246259952082e-13 miRNATAP -0.202238939720509 1.9524950223322e-14 NA NA NA hsa-miR-141-3p KATNAL1 -5.02396127982626 2.19224509139725e-24 1.57600243048234 8.1570400150905e-06 TargetScan -0.399081005798051 1.42565068629602e-40 NA NA NA hsa-miR-141-3p KBTBD11 -5.02396127982626 2.19224509139725e-24 2.19338266624559 6.41970854972391e-08 mirMAP -0.207712957508786 3.24509579623034e-08 NA NA NA hsa-miR-141-3p KCNIP4 -5.02396127982626 2.19224509139725e-24 1.64344411900392 3.99391332083591e-14 MirTarget -0.115762588911047 1.42923692275574e-08 NA NA NA hsa-miR-141-3p KCNJ2 -5.02396127982626 2.19224509139725e-24 0.281197518883409 0.36164514317052 TargetScan;miRNATAP -0.13499003532713 1.68671807814994e-06 NA NA NA hsa-miR-141-3p KCNK3 -5.02396127982626 2.19224509139725e-24 3.6338132446768 1.0612212729052e-10 mirMAP -0.536679604994079 7.34243209122856e-27 NA NA NA hsa-miR-141-3p KCTD12 -5.02396127982626 2.19224509139725e-24 1.63231238822131 6.91166356828626e-08 TargetScan -0.35610805061715 3.26382891941958e-44 NA NA NA hsa-miR-141-3p KCTD20 -5.02396127982626 2.19224509139725e-24 0.81380310423214 2.36532656017097e-06 MirTarget;TargetScan -0.115246052153293 1.79621314879822e-13 NA NA NA hsa-miR-141-3p KCTD7 -5.02396127982626 2.19224509139725e-24 0.720453948905685 7.81616343021259e-05 mirMAP -0.123682791343706 6.04208833240884e-14 NA NA NA hsa-miR-141-3p KHDC1 -5.02396127982626 2.19224509139725e-24 0.636944502978113 0.156898551752884 miRNATAP -0.266703226249492 5.80516402692101e-11 NA NA NA hsa-miR-141-3p KHDRBS3 -5.02396127982626 2.19224509139725e-24 1.40834477366019 0.00168295652691807 TargetScan -0.237387720367083 7.00246755571617e-09 NA NA NA hsa-miR-141-3p KIAA0408 -5.02396127982626 2.19224509139725e-24 6.34871008421869 6.23110294275815e-17 MirTarget;TargetScan -0.604271666983291 7.79609944603074e-18 NA NA NA hsa-miR-141-3p KIAA1644 -5.02396127982626 2.19224509139725e-24 4.40439862301283 1.42085780669106e-16 mirMAP -0.716686333897475 1.50217356415633e-58 NA NA NA hsa-miR-141-3p KIAA2022 -5.02396127982626 2.19224509139725e-24 3.77781848258777 1.47825574429183e-12 MirTarget;TargetScan -0.439294725422072 1.58112385618876e-19 NA NA NA hsa-miR-141-3p KIF17 -5.02396127982626 2.19224509139725e-24 1.22170857097799 7.98355624690093e-05 MirTarget;TargetScan -0.29774784532447 2.72875897598259e-28 NA NA NA hsa-miR-141-3p KIF1B -5.02396127982626 2.19224509139725e-24 0.678468502639351 1.60841697720091e-05 mirMAP -0.100473248145699 1.95834362605822e-12 NA NA NA hsa-miR-141-3p KLF11 -5.02396127982626 2.19224509139725e-24 0.893024981436909 6.97406562236951e-06 miRNAWalker2_validate;MirTarget -0.109127392186737 2.1048242253222e-09 NA NA NA hsa-miR-141-3p KLF12 -5.02396127982626 2.19224509139725e-24 1.46917100719464 1.42059321169595e-05 MirTarget;TargetScan -0.306963108494665 7.72867329137965e-25 NA NA NA hsa-miR-141-3p KLF6 -5.02396127982626 2.19224509139725e-24 1.55016190855485 5.472578713976e-12 TargetScan;miRNATAP -0.109493712289628 2.03959262644186e-07 NA NA NA hsa-miR-141-3p KPNA3 -5.02396127982626 2.19224509139725e-24 0.573359539342798 0.00262291748998799 MirTarget;TargetScan;miRNATAP -0.100889364758159 6.41762677485833e-09 NA NA NA hsa-miR-141-3p LCP2 -5.02396127982626 2.19224509139725e-24 0.697473139527701 0.05180412829542 MirTarget -0.292356176350176 2.94269967183768e-20 NA NA NA hsa-miR-141-3p LHFP -5.02396127982626 2.19224509139725e-24 1.83125704677192 4.20141501543419e-10 MirTarget -0.332640509877499 5.90653624144378e-40 NA NA NA hsa-miR-141-3p LHX6 -5.02396127982626 2.19224509139725e-24 0.886870795693207 0.00203651922651582 MirTarget;TargetScan;miRNATAP -0.1925609723839 1.13024579333871e-13 NA NA NA hsa-miR-141-3p LIF -5.02396127982626 2.19224509139725e-24 1.6300990984737 3.4687907876716e-05 mirMAP -0.211882464421913 4.50278438467506e-09 NA NA NA hsa-miR-141-3p LMO3 -5.02396127982626 2.19224509139725e-24 4.72180755919393 2.71125773614459e-13 MirTarget;TargetScan -0.479006861419375 8.39238892548966e-16 NA NA NA hsa-miR-141-3p LONRF2 -5.02396127982626 2.19224509139725e-24 3.8642101573018 7.90463940348432e-08 TargetScan -0.288517477326301 1.73240320824398e-05 NA NA NA hsa-miR-141-3p LPIN2 -5.02396127982626 2.19224509139725e-24 0.6452185638948 0.0164829454490251 TargetScan -0.128406002392285 1.81732698831014e-07 NA NA NA hsa-miR-141-3p LPP -5.02396127982626 2.19224509139725e-24 2.04092311415528 2.98839088727509e-15 TargetScan;miRNATAP -0.229401213243655 1.67846288845394e-22 NA NA NA hsa-miR-141-3p LSAMP -5.02396127982626 2.19224509139725e-24 2.02817683260413 4.22567550720739e-06 TargetScan -0.277344367575573 5.56843771499789e-12 NA NA NA hsa-miR-141-3p LTBP1 -5.02396127982626 2.19224509139725e-24 1.09891861471167 0.000129213237016859 MirTarget -0.211434558427624 2.47291192802919e-16 NA NA NA hsa-miR-141-3p MACF1 -5.02396127982626 2.19224509139725e-24 0.874277509919212 1.10820730213313e-06 TargetScan -0.173333337794005 2.19082057923565e-28 NA NA NA hsa-miR-141-3p MAF -5.02396127982626 2.19224509139725e-24 1.28341922239874 0.000158252136628823 miRNATAP -0.30818214426818 5.41571256021845e-25 NA NA NA hsa-miR-141-3p MAGI2 -5.02396127982626 2.19224509139725e-24 1.89478051791337 8.17403291700615e-13 TargetScan;miRNATAP -0.156969824639809 1.99328593268779e-10 NA NA NA hsa-miR-141-3p MAP1B -5.02396127982626 2.19224509139725e-24 3.18358434812783 4.83606017602339e-16 mirMAP -0.542040813296232 2.39221657606778e-63 NA NA NA hsa-miR-141-3p MAP2 -5.02396127982626 2.19224509139725e-24 0.753572928246066 0.097078063739555 miRNATAP -0.224308127471618 6.27701437913552e-08 NA NA NA hsa-miR-141-3p MAP3K3 -5.02396127982626 2.19224509139725e-24 0.867302315651696 4.69975718275891e-09 miRNATAP -0.172869710454037 2.24127810311963e-43 NA NA NA hsa-miR-141-3p MAP4K4 -5.02396127982626 2.19224509139725e-24 -0.130872521838524 0.522814141079276 TargetScan -0.132557176493888 5.6923535135779e-13 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-141-3p MAP7D1 -5.02396127982626 2.19224509139725e-24 0.5193331781252 0.00190259325110533 MirTarget;TargetScan;miRNATAP -0.139324129382877 3.90527399743627e-21 NA NA NA hsa-miR-141-3p MAPRE2 -5.02396127982626 2.19224509139725e-24 1.48556495228465 7.11230591567598e-09 TargetScan -0.297976282854019 1.42852580439143e-42 NA NA NA hsa-miR-141-3p MARCH1 -5.02396127982626 2.19224509139725e-24 -0.249895584717323 0.347593448523703 TargetScan;miRNATAP -0.156359618437464 8.01678188057464e-11 NA NA NA hsa-miR-141-3p MBNL1 -5.02396127982626 2.19224509139725e-24 1.03715217368982 1.91023114600066e-14 MirTarget;TargetScan;miRNATAP -0.145917544232527 9.07487014206932e-35 NA NA NA hsa-miR-141-3p MBNL3 -5.02396127982626 2.19224509139725e-24 1.39664025928726 7.58496847232075e-05 MirTarget;TargetScan;miRNATAP -0.118158255437449 0.000310538356420404 NA NA NA hsa-miR-141-3p MDGA1 -5.02396127982626 2.19224509139725e-24 1.00154386684221 0.0303398006837731 TargetScan;miRNATAP -0.351329630228369 1.52044327594317e-17 NA NA NA hsa-miR-210-3p MDGA1 -6.07079758655679 2.22120227133377e-28 1.00154386684221 0.0303398006837731 miRNAWalker2_validate -0.177758156373944 2.379457505793e-06 NA NA NA hsa-miR-141-3p MEIS2 -5.02396127982626 2.19224509139725e-24 1.72135417174124 5.81040155633474e-11 TargetScan -0.160153615098597 4.73599763955798e-11 NA NA NA hsa-miR-141-3p MGAT5 -5.02396127982626 2.19224509139725e-24 0.94820585641047 0.00642407288737585 TargetScan;mirMAP -0.119333456003193 0.000203629579724751 NA NA NA hsa-miR-141-3p MMP16 -5.02396127982626 2.19224509139725e-24 1.93731176203338 4.78308892783825e-06 TargetScan -0.393402814041786 4.69903101645432e-26 NA NA NA hsa-miR-141-3p MN1 -5.02396127982626 2.19224509139725e-24 2.44287385467581 8.23641446859367e-08 TargetScan -0.469862250730746 1.87729549679021e-32 NA NA NA hsa-miR-210-3p MPEG1 -6.07079758655679 2.22120227133377e-28 1.65814079681193 3.85903819290947e-05 MirTarget -0.320085307825935 3.4230493374086e-24 NA NA NA hsa-miR-141-3p MYBL1 -5.02396127982626 2.19224509139725e-24 0.198825078797648 0.492088677772152 TargetScan;miRNATAP -0.176286176102791 1.47359490638079e-11 NA NA NA hsa-miR-141-3p MYH10 -5.02396127982626 2.19224509139725e-24 0.113066852038279 0.614876476546516 TargetScan;miRNATAP -0.153321303486404 2.48531788097192e-14 NA NA NA hsa-miR-141-3p MYO5A -5.02396127982626 2.19224509139725e-24 0.274576441491864 0.31162033508461 TargetScan -0.206712590727665 9.59919356304138e-18 NA NA NA hsa-miR-141-3p MYO9A -5.02396127982626 2.19224509139725e-24 1.29622192336459 1.1786138431555e-06 TargetScan -0.14343034253547 5.21704135269981e-09 NA NA NA hsa-miR-141-3p MYRIP -5.02396127982626 2.19224509139725e-24 3.805552903458 1.14017259779896e-12 MirTarget;TargetScan -0.199903098152316 7.8826439177152e-05 NA NA NA hsa-miR-141-3p NAMPT -5.02396127982626 2.19224509139725e-24 1.01188888675403 7.9862157499149e-05 miRNATAP -0.137907485727215 4.38663947784095e-09 NA NA NA hsa-miR-141-3p NAV3 -5.02396127982626 2.19224509139725e-24 3.21771083204903 7.35356644104861e-11 mirMAP -0.606782843027449 3.71206011455211e-48 NA NA NA hsa-miR-141-3p NCAM1 -5.02396127982626 2.19224509139725e-24 5.46812766536887 2.35522582039703e-18 TargetScan -0.805643363470641 1.26938223389983e-51 NA NA NA hsa-miR-210-3p NCAM1 -6.07079758655679 2.22120227133377e-28 5.46812766536887 2.35522582039703e-18 miRNAWalker2_validate;miRTarBase -0.689476481684231 4.68819389749096e-47 NA NA NA hsa-miR-141-3p NECAB1 -5.02396127982626 2.19224509139725e-24 3.26252425353249 2.74412248921453e-12 MirTarget;TargetScan -0.490602041605141 5.38471060642007e-33 NA NA NA hsa-miR-141-3p NEK6 -5.02396127982626 2.19224509139725e-24 0.544239957677026 0.104572175212416 MirTarget;TargetScan -0.308507320351745 3.84776984127134e-26 NA NA NA hsa-miR-141-3p NEURL1B -5.02396127982626 2.19224509139725e-24 1.41325934404162 2.67307373486688e-07 mirMAP -0.231737019794621 3.59108379699189e-21 NA NA NA hsa-miR-141-3p NFASC -5.02396127982626 2.19224509139725e-24 2.95717922837884 4.31475260476473e-14 MirTarget;TargetScan;miRNATAP -0.304221401150199 2.88851937906312e-17 NA NA NA hsa-miR-141-3p NFIA -5.02396127982626 2.19224509139725e-24 2.09936885926166 1.0458025267903e-15 TargetScan;miRNATAP -0.21056311469311 2.19268296919497e-18 NA NA NA hsa-miR-141-3p NMNAT2 -5.02396127982626 2.19224509139725e-24 0.388609911601026 0.428797428186375 miRNATAP -0.225154516940894 5.2650384281902e-07 NA NA NA hsa-miR-141-3p NOVA1 -5.02396127982626 2.19224509139725e-24 4.21914714578111 7.21315612695773e-16 miRNATAP -0.429459072642794 4.17969981650815e-19 NA NA NA hsa-miR-141-3p NPAS3 -5.02396127982626 2.19224509139725e-24 2.24907906516082 1.91416491531776e-06 TargetScan;miRNATAP -0.31082359651629 5.11859388646725e-13 NA NA NA hsa-miR-141-3p NPC1 -5.02396127982626 2.19224509139725e-24 0.0845907427747123 0.656311240831079 MirTarget;TargetScan -0.10141342572552 3.99908798547029e-09 NA NA NA hsa-miR-141-3p NPTX1 -5.02396127982626 2.19224509139725e-24 3.0548528465665 5.58655593069716e-09 TargetScan;miRNATAP -0.317221091523751 5.28128507298689e-11 NA NA NA hsa-miR-210-3p NPTX1 -6.07079758655679 2.22120227133377e-28 3.0548528465665 5.58655593069716e-09 miRNAWalker2_validate;miRTarBase -0.334749226448501 3.07349072508097e-15 NA NA NA hsa-miR-141-3p NR3C1 -5.02396127982626 2.19224509139725e-24 1.29490546417786 3.89055618845502e-05 TargetScan -0.295170348516288 9.42370767036473e-27 NA NA NA hsa-miR-141-3p NRCAM -5.02396127982626 2.19224509139725e-24 -1.51659381182303 0.003170728944007 TargetScan -0.105508016559009 0.0271834551730992 NA NA NA hsa-miR-141-3p NRP1 -5.02396127982626 2.19224509139725e-24 0.612408058927576 0.0291452451283254 TargetScan;miRNATAP -0.255348299355813 1.85031947127184e-25 NA NA NA hsa-miR-141-3p NRP2 -5.02396127982626 2.19224509139725e-24 1.68096989171122 2.48125634647156e-05 TargetScan;miRNATAP -0.502017233487188 2.96922549758946e-53 NA NA NA hsa-miR-141-3p NRSN2 -5.02396127982626 2.19224509139725e-24 0.330465623325307 0.250945572044972 MirTarget -0.110325550270995 2.96428406227536e-05 NA NA NA hsa-miR-141-3p NRXN1 -5.02396127982626 2.19224509139725e-24 6.57168194390169 3.69107862170811e-26 MirTarget;TargetScan;miRNATAP -0.667046956110465 6.52379560861006e-32 NA NA NA hsa-miR-141-3p NTRK3 -5.02396127982626 2.19224509139725e-24 5.17034960965042 5.23662623079406e-21 mirMAP -0.496811560602054 1.26226870960282e-22 NA NA NA hsa-miR-141-3p NUMBL -5.02396127982626 2.19224509139725e-24 0.572631697203965 0.00314600902770344 TargetScan -0.150911963397294 2.13456017848362e-18 NA NA NA hsa-miR-141-3p OGFRL1 -5.02396127982626 2.19224509139725e-24 0.562576926083617 0.128325913264998 TargetScan -0.265931932396274 8.72716128230255e-16 NA NA NA hsa-miR-141-3p OLFM1 -5.02396127982626 2.19224509139725e-24 3.69448823851136 3.94169138374679e-16 MirTarget;TargetScan;miRNATAP -0.457030729324371 2.53149879132377e-29 NA NA NA hsa-miR-141-3p OLFML2A -5.02396127982626 2.19224509139725e-24 1.02635324218331 0.000962903460469674 mirMAP -0.216135583464069 1.17744624452523e-14 NA NA NA hsa-miR-141-3p OSBPL10 -5.02396127982626 2.19224509139725e-24 1.83322990423673 6.62607328092408e-12 mirMAP -0.239912030168834 1.53794516155206e-23 NA NA NA hsa-miR-141-3p OSBPL1A -5.02396127982626 2.19224509139725e-24 1.28931675013637 1.82641604881754e-06 TargetScan -0.180936045111728 1.80508686660405e-13 NA NA NA hsa-miR-141-3p OSBPL6 -5.02396127982626 2.19224509139725e-24 1.61152035107552 0.00474080031102195 MirTarget;TargetScan;miRNATAP -0.542659142890387 7.41773493874935e-28 NA NA NA hsa-miR-141-3p P2RY1 -5.02396127982626 2.19224509139725e-24 1.88677816260566 6.94120829937243e-05 TargetScan -0.131524674767249 0.00289329932777245 NA NA NA hsa-miR-141-3p PALM2-AKAP2 -5.02396127982626 2.19224509139725e-24 1.62425751829219 3.00539592164246e-07 TargetScan;miRNATAP -0.378702933299226 4.70023082891259e-46 NA NA NA hsa-miR-141-3p PAPLN -5.02396127982626 2.19224509139725e-24 0.241943294054047 0.455530000462734 TargetScan -0.192564254132522 4.98870627642303e-11 NA NA NA hsa-miR-141-3p PAPPA -5.02396127982626 2.19224509139725e-24 1.75955305841573 0.000134461135734203 MirTarget;TargetScan;miRNATAP -0.347370588052235 4.46409718289252e-17 NA NA NA hsa-miR-141-3p PAQR5 -5.02396127982626 2.19224509139725e-24 0.024725230110193 0.956044849342468 MirTarget;TargetScan -0.129292481797794 0.00176773845410547 NA NA NA hsa-miR-141-3p PAX3 -5.02396127982626 2.19224509139725e-24 0.660994210613065 0.281011412138485 TargetScan -0.119014117319377 0.0359774490427443 NA NA NA hsa-miR-141-3p PCDH17 -5.02396127982626 2.19224509139725e-24 0.315438288171691 0.277167062556602 miRNATAP -0.147564899122846 2.34395281845491e-08 NA NA NA hsa-miR-141-3p PCDH9 -5.02396127982626 2.19224509139725e-24 3.58942089789522 1.1728510194399e-09 MirTarget;miRNATAP -0.590356224897316 5.28325615006607e-30 NA NA NA hsa-miR-210-3p PCYT1B -6.07079758655679 2.22120227133377e-28 1.53756359837056 0.00358733905606095 MirTarget -0.216658094189243 4.78043241593753e-07 NA NA NA hsa-miR-141-3p PDE1C -5.02396127982626 2.19224509139725e-24 4.13701966391323 7.08661414779578e-16 mirMAP -0.511083039603708 1.03070480064241e-28 NA NA NA hsa-miR-141-3p PDGFRA -5.02396127982626 2.19224509139725e-24 2.37640583073564 1.39737819859364e-09 MirTarget -0.379513640202387 7.11112956696243e-28 NA NA NA hsa-miR-141-3p PDZD2 -5.02396127982626 2.19224509139725e-24 0.660901601186235 0.0797147776322328 TargetScan -0.181839965659049 1.30740485459763e-07 NA NA NA hsa-miR-210-3p PDZD4 -6.07079758655679 2.22120227133377e-28 3.50328419678476 5.69234493908276e-16 MirTarget -0.334937591822741 1.37127211346789e-21 NA NA NA hsa-miR-141-3p PEG3 -5.02396127982626 2.19224509139725e-24 3.78948650332683 1.02338376531654e-12 TargetScan -0.346980443744125 2.01508846200066e-12 NA NA NA hsa-miR-141-3p PGM2L1 -5.02396127982626 2.19224509139725e-24 1.01115316371047 0.000101645754958709 TargetScan -0.228633666115396 2.2474024963306e-23 NA NA NA hsa-miR-141-3p PHLPP2 -5.02396127982626 2.19224509139725e-24 0.542526414508153 0.00198752699211244 MirTarget;TargetScan;miRNATAP -0.104884442280012 4.29809622480929e-11 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-141-3p PHYHIPL -5.02396127982626 2.19224509139725e-24 1.3403818845059 0.0209589994726951 MirTarget;TargetScan;miRNATAP -0.245737656387445 4.07445009992431e-06 NA NA NA hsa-miR-141-3p PITX2 -5.02396127982626 2.19224509139725e-24 2.22753708360439 1.34545225235817e-06 TargetScan;miRNATAP -0.274614578689398 8.14562643219687e-11 NA NA NA hsa-miR-141-3p PLCB4 -5.02396127982626 2.19224509139725e-24 3.76947582666435 4.09541818232211e-14 TargetScan -0.288518356683351 6.78415934849381e-10 NA NA NA hsa-miR-141-3p PLCL1 -5.02396127982626 2.19224509139725e-24 2.35657424868599 1.25135556692163e-13 MirTarget;TargetScan -0.385622908652975 6.97070144503964e-46 NA NA NA hsa-miR-141-3p PLCXD3 -5.02396127982626 2.19224509139725e-24 2.49859819439077 0.000929772953384919 TargetScan;miRNATAP -0.327272917943613 2.51002064529902e-06 NA NA NA hsa-miR-141-3p PLEK -5.02396127982626 2.19224509139725e-24 1.06777187361753 0.0183920114681949 MirTarget;TargetScan -0.416536150215066 5.28530186133013e-26 NA NA NA hsa-miR-141-3p PLXDC1 -5.02396127982626 2.19224509139725e-24 -0.00175712757885327 0.99488659192134 TargetScan -0.170965597655904 4.42601030183858e-12 NA NA NA hsa-miR-141-3p PLXNA4 -5.02396127982626 2.19224509139725e-24 2.25456361904941 4.96438419774257e-05 TargetScan;miRNATAP -0.601006964484541 9.07505928234085e-37 NA NA NA hsa-miR-141-3p PLXNC1 -5.02396127982626 2.19224509139725e-24 0.532339572840621 0.284697523094741 TargetScan;miRNATAP -0.419915469975757 8.28969677413453e-22 NA NA NA hsa-miR-141-3p PMP2 -5.02396127982626 2.19224509139725e-24 5.56668654102548 1.59099235313422e-29 MirTarget -0.47509254605832 1.06847142693911e-24 NA NA NA hsa-miR-210-3p POU2AF1 -6.07079758655679 2.22120227133377e-28 1.46755689949793 0.0109293207761813 MirTarget -0.281143675042498 1.66972066102077e-09 NA NA NA hsa-miR-141-3p PPFIBP1 -5.02396127982626 2.19224509139725e-24 0.621062569088302 0.00342767338822477 MirTarget -0.124598490344997 9.9593340960011e-11 NA NA NA hsa-miR-141-3p PPM1K -5.02396127982626 2.19224509139725e-24 1.58286610479163 4.19807618138064e-10 MirTarget -0.232563766177752 7.1110964214171e-25 NA NA NA hsa-miR-141-3p PRDM16 -5.02396127982626 2.19224509139725e-24 2.56004666228196 1.1360029849919e-06 mirMAP -0.285615772222806 3.77579221461135e-09 NA NA NA hsa-miR-141-3p PRELP -5.02396127982626 2.19224509139725e-24 4.33165618526589 1.88859496920037e-15 mirMAP -0.583968584944458 8.1167541065303e-34 NA NA NA hsa-miR-141-3p PRICKLE1 -5.02396127982626 2.19224509139725e-24 1.64440101214104 0.000132852800511826 TargetScan -0.396289457266669 8.83434530890621e-26 NA NA NA hsa-miR-141-3p PRKAA2 -5.02396127982626 2.19224509139725e-24 3.1651157275578 4.06046613880042e-09 mirMAP -0.311674641790567 3.76173236669185e-10 NA NA NA hsa-miR-141-3p PRKACB -5.02396127982626 2.19224509139725e-24 1.11910356116881 7.24897707751734e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 NA NA NA hsa-miR-141-3p PRKD1 -5.02396127982626 2.19224509139725e-24 1.53164811371414 4.11903802509395e-05 MirTarget;TargetScan -0.237495524984123 2.75579921362746e-12 NA NA NA hsa-miR-210-3p PROK1 -6.07079758655679 2.22120227133377e-28 2.26546093581453 3.242054057071e-05 MirTarget -0.247463304325384 2.71732353207776e-08 NA NA NA hsa-miR-141-3p PRRT2 -5.02396127982626 2.19224509139725e-24 1.59688997506932 1.79697445742208e-07 mirMAP -0.126860296680001 8.38284619506957e-06 NA NA NA hsa-miR-141-3p PTP4A1 -5.02396127982626 2.19224509139725e-24 0.886199664882351 4.27122299209584e-05 TargetScan;miRNATAP -0.107658681672777 6.31240831148277e-08 NA NA NA hsa-miR-141-3p PTPRD -5.02396127982626 2.19224509139725e-24 3.62979486144354 1.88740064210481e-09 miRNAWalker2_validate;TargetScan;miRNATAP -0.584125755153581 7.51406235840796e-28 NA NA NA hsa-miR-141-3p PTPRG -5.02396127982626 2.19224509139725e-24 0.659570164498503 0.0398812996716311 MirTarget;TargetScan;miRNATAP -0.201132411796231 3.96262000395438e-12 NA NA NA hsa-miR-141-3p PXK -5.02396127982626 2.19224509139725e-24 1.04685086128216 1.54718294430704e-05 MirTarget;TargetScan -0.193272651927338 4.38086874952318e-19 NA NA NA hsa-miR-141-3p QKI -5.02396127982626 2.19224509139725e-24 0.45971292399632 0.0044082412437115 TargetScan -0.132360282337828 1.6791400486828e-20 NA NA NA hsa-miR-141-3p RAB30 -5.02396127982626 2.19224509139725e-24 1.46673818899504 1.29730263099076e-07 TargetScan;miRNATAP -0.23300147587448 7.08228298452366e-21 NA NA NA hsa-miR-141-3p RAD54L2 -5.02396127982626 2.19224509139725e-24 0.815712955264483 0.00569192771172009 TargetScan -0.113896459197961 2.77631892360301e-05 NA NA NA hsa-miR-141-3p RAPGEF5 -5.02396127982626 2.19224509139725e-24 0.580986175597247 0.0366906480299318 MirTarget -0.141329721270982 2.51336087847175e-08 NA NA NA hsa-miR-141-3p RARB -5.02396127982626 2.19224509139725e-24 1.77858429602091 2.28807354868445e-06 TargetScan;miRNATAP -0.304531803254532 1.62106913139083e-19 NA NA NA hsa-miR-141-3p RASA4 -5.02396127982626 2.19224509139725e-24 1.1892508233376 1.32902275444345e-05 mirMAP -0.119498282223186 2.20769572742455e-06 NA NA NA hsa-miR-141-3p RASSF2 -5.02396127982626 2.19224509139725e-24 1.41203583911444 3.41019630784434e-05 miRNAWalker2_validate -0.157926960511219 5.03862422283406e-07 NA NA NA hsa-miR-141-3p RASSF8 -5.02396127982626 2.19224509139725e-24 1.48887021923134 4.62579164697904e-06 TargetScan -0.311148360551181 7.8439318105715e-28 NA NA NA hsa-miR-141-3p RBM20 -5.02396127982626 2.19224509139725e-24 2.46227191748389 1.31938346873951e-07 TargetScan -0.236201470484319 4.61015753528414e-08 NA NA NA hsa-miR-141-3p RBM24 -5.02396127982626 2.19224509139725e-24 4.71296042197799 2.54821528082855e-19 TargetScan -0.658965509843211 3.12237554235179e-48 NA NA NA hsa-miR-141-3p RBM7 -5.02396127982626 2.19224509139725e-24 0.635938038315607 2.10598323164859e-05 MirTarget;TargetScan;miRNATAP -0.107318080211912 1.47935679368622e-15 NA NA NA hsa-miR-141-3p RFTN1 -5.02396127982626 2.19224509139725e-24 0.515091372232221 0.0525029974344917 MirTarget -0.227638891906773 1.75169853730135e-22 NA NA NA hsa-miR-141-3p RGS7BP -5.02396127982626 2.19224509139725e-24 2.88914091526269 2.34477447109267e-08 TargetScan;miRNATAP -0.211449117549126 1.2027138373104e-05 NA NA NA hsa-miR-141-3p RHOBTB1 -5.02396127982626 2.19224509139725e-24 0.383169433464757 0.11383180079181 TargetScan;miRNATAP -0.113091323194795 3.22638694537484e-07 NA NA NA hsa-miR-141-3p RIMBP2 -5.02396127982626 2.19224509139725e-24 2.69405047193145 5.63343241147361e-07 mirMAP -0.37984022246925 8.07929141975062e-15 NA NA NA hsa-miR-141-3p RIMS1 -5.02396127982626 2.19224509139725e-24 2.89281441012069 1.04553689329755e-08 MirTarget;TargetScan -0.242239428864956 2.60255661814804e-07 NA NA NA hsa-miR-141-3p RIMS3 -5.02396127982626 2.19224509139725e-24 1.42027619315578 3.00440701262036e-05 mirMAP -0.220452503245957 1.02693817231772e-12 NA NA NA hsa-miR-141-3p RNF115 -5.02396127982626 2.19224509139725e-24 0.493974122722624 0.000544040488544075 TargetScan -0.118566602984434 5.68680615752015e-21 NA NA NA hsa-miR-141-3p RNF145 -5.02396127982626 2.19224509139725e-24 1.13456828501773 4.01788098713661e-06 MirTarget;TargetScan;miRNATAP -0.166889329474487 7.91018859563463e-14 NA NA NA hsa-miR-141-3p RNF217 -5.02396127982626 2.19224509139725e-24 1.13715450185669 0.0097437081213251 mirMAP -0.265655612126002 2.76054040770475e-11 NA NA NA hsa-miR-141-3p RORA -5.02396127982626 2.19224509139725e-24 1.82057461685128 1.16708465709095e-09 MirTarget;TargetScan;miRNATAP -0.2095334795559 1.95769501043743e-14 NA NA NA hsa-miR-141-3p RSAD2 -5.02396127982626 2.19224509139725e-24 -1.09050448915748 0.0183343807979863 MirTarget -0.132649867541437 0.0019213852285425 NA NA NA hsa-miR-141-3p RSPO2 -5.02396127982626 2.19224509139725e-24 3.93336099497493 9.57664391177389e-09 MirTarget -0.690123556120629 1.43585648200077e-30 NA NA NA hsa-miR-141-3p RSPO3 -5.02396127982626 2.19224509139725e-24 3.95134870437563 1.03895511845117e-08 TargetScan -0.808555175879442 2.02316236051444e-43 NA NA NA hsa-miR-141-3p RTN4RL1 -5.02396127982626 2.19224509139725e-24 1.53902047251327 0.00925768188843254 TargetScan -0.194438650090712 0.000373771138806894 NA NA NA hsa-miR-210-3p SCARA3 -6.07079758655679 2.22120227133377e-28 1.80909791414434 3.3095266545769e-05 MirTarget -0.276814578754791 2.27886426319528e-15 NA NA NA hsa-miR-141-3p SCD5 -5.02396127982626 2.19224509139725e-24 1.12475299400773 0.00624411697003675 TargetScan -0.240125902404556 1.32734052396633e-10 NA NA NA hsa-miR-141-3p SCHIP1 -5.02396127982626 2.19224509139725e-24 1.15670143162604 1.15787017339653e-06 MirTarget;TargetScan -0.214489615338193 1.9767324070416e-24 NA NA NA hsa-miR-210-3p SCN1B -6.07079758655679 2.22120227133377e-28 2.06795854735244 3.41501873074011e-08 miRNAWalker2_validate -0.324210356787498 1.42331107565226e-28 NA NA NA hsa-miR-141-3p SCN2B -5.02396127982626 2.19224509139725e-24 4.29366513636715 3.96960287530702e-15 MirTarget;miRNATAP -0.638194361703234 2.14387468321129e-41 NA NA NA hsa-miR-141-3p SCN7A -5.02396127982626 2.19224509139725e-24 6.11978160757835 2.73266450670555e-23 TargetScan -0.646026492790804 8.01655537553871e-31 NA NA NA hsa-miR-141-3p SCN9A -5.02396127982626 2.19224509139725e-24 1.38434426315237 0.00934391039271173 TargetScan -0.283729563080483 5.27232326685952e-09 NA NA NA hsa-miR-141-3p SDC2 -5.02396127982626 2.19224509139725e-24 2.00706478458987 1.28300608152733e-09 MirTarget;TargetScan -0.310783666482765 3.28501520743697e-26 NA NA NA hsa-miR-141-3p SDK2 -5.02396127982626 2.19224509139725e-24 1.5208913772195 0.00193103042800784 mirMAP -0.121356658714764 0.00771224223698089 NA NA NA hsa-miR-141-3p SERINC1 -5.02396127982626 2.19224509139725e-24 1.06295473287643 5.4935021142339e-13 TargetScan -0.130431422061671 8.42733307068602e-23 NA NA NA hsa-miR-141-3p SETBP1 -5.02396127982626 2.19224509139725e-24 2.26227903514797 8.87237114441658e-09 miRNATAP -0.347927487477622 3.86550056477612e-23 NA NA NA hsa-miR-141-3p SH2B3 -5.02396127982626 2.19224509139725e-24 0.500441864762741 0.032566539093735 MirTarget -0.226410213969775 4.19058191235717e-29 NA NA NA hsa-miR-210-3p SH3BGRL -6.07079758655679 2.22120227133377e-28 1.43100123895074 2.53257963935935e-09 MirTarget -0.168458515572699 2.38969389314932e-18 NA NA NA hsa-miR-141-3p SH3PXD2B -5.02396127982626 2.19224509139725e-24 0.539989314189261 0.013917558578879 mirMAP -0.179780699601216 1.95459017815311e-20 NA NA NA hsa-miR-141-3p SHE -5.02396127982626 2.19224509139725e-24 2.12174612226388 6.45456472105851e-13 mirMAP -0.326614936882251 4.73184300032631e-37 NA NA NA hsa-miR-141-3p SIDT2 -5.02396127982626 2.19224509139725e-24 0.567487094559556 0.000188317708358996 TargetScan -0.122225200019388 1.35110713577519e-19 NA NA NA hsa-miR-141-3p SIGLEC1 -5.02396127982626 2.19224509139725e-24 0.883561500953727 0.056709845034122 mirMAP -0.412785562481062 2.55871079902601e-24 NA NA NA hsa-miR-141-3p SLC16A7 -5.02396127982626 2.19224509139725e-24 2.19116423885911 1.90683758447503e-07 MirTarget;TargetScan;miRNATAP -0.212304427193396 4.98656876124468e-08 NA NA NA hsa-miR-141-3p SLC18A2 -5.02396127982626 2.19224509139725e-24 2.15025936730909 8.02147349359414e-07 TargetScan -0.332963569751475 2.38258210225741e-17 NA NA NA hsa-miR-141-3p SLC1A7 -5.02396127982626 2.19224509139725e-24 1.52314391957884 0.00854832871092884 MirTarget -0.159838803306678 0.00288878558850445 NA NA NA hsa-miR-141-3p SLC6A17 -5.02396127982626 2.19224509139725e-24 -0.941104200796899 0.0568131902197337 miRNATAP -0.281974703353835 3.24996818288571e-10 NA NA NA hsa-miR-141-3p SLC6A9 -5.02396127982626 2.19224509139725e-24 0.447894573870129 0.140243510464252 MirTarget;TargetScan;miRNATAP -0.173302451949557 3.06109998163885e-10 NA NA NA hsa-miR-141-3p SNAP25 -5.02396127982626 2.19224509139725e-24 1.14591384974572 0.0327342558924054 TargetScan -0.415223382838874 3.37769006907081e-18 NA NA NA hsa-miR-141-3p SOBP -5.02396127982626 2.19224509139725e-24 3.18866782050437 2.41809868609207e-18 MirTarget;TargetScan -0.382546629954663 1.19835856525009e-31 NA NA NA hsa-miR-141-3p SORBS2 -5.02396127982626 2.19224509139725e-24 3.6862885145227 2.51155368959186e-15 MirTarget;TargetScan -0.289514379293369 3.3173229682062e-11 NA NA NA hsa-miR-141-3p SOX17 -5.02396127982626 2.19224509139725e-24 2.94798887132292 6.52451561011194e-21 TargetScan -0.256726942553231 1.9475675823917e-18 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-141-3p SOX5 -5.02396127982626 2.19224509139725e-24 2.80899915084138 3.6954633681337e-12 TargetScan;miRNATAP -0.33437484410152 8.78039970287997e-20 NA NA NA hsa-miR-141-3p SOX6 -5.02396127982626 2.19224509139725e-24 2.16170894059309 7.49520430040927e-06 TargetScan;mirMAP -0.153973602739025 0.000616698218830245 NA NA NA hsa-miR-141-3p SPN -5.02396127982626 2.19224509139725e-24 1.0962197092516 0.00559106860717584 mirMAP -0.264085380015187 1.33910289632965e-13 NA NA NA hsa-miR-141-3p SPOCK2 -5.02396127982626 2.19224509139725e-24 0.420533703560182 0.249689356708973 TargetScan;miRNATAP -0.147135893584673 1.12681361701074e-05 NA NA NA hsa-miR-141-3p SPRED1 -5.02396127982626 2.19224509139725e-24 0.640045955246492 0.00626859347930185 miRNATAP -0.172766117206038 1.51843479785622e-16 NA NA NA hsa-miR-141-3p SSTR1 -5.02396127982626 2.19224509139725e-24 4.05163916158795 1.40315760741537e-13 mirMAP -0.279903649938154 5.62031507156795e-08 NA NA NA hsa-miR-141-3p ST3GAL3 -5.02396127982626 2.19224509139725e-24 1.09370616658902 5.68245266413659e-09 MirTarget;TargetScan;miRNATAP -0.174247098126514 1.06036590974725e-25 NA NA NA hsa-miR-141-3p ST6GALNAC3 -5.02396127982626 2.19224509139725e-24 2.04578308207892 3.034429328167e-11 mirMAP -0.271703112243442 9.6877521130857e-23 NA NA NA hsa-miR-141-3p STAT4 -5.02396127982626 2.19224509139725e-24 0.54405037149823 0.200971233130196 MirTarget;TargetScan -0.226416599746781 4.86462094089995e-09 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-141-3p STAT5A -5.02396127982626 2.19224509139725e-24 0.684955697233735 0.000967420523261087 MirTarget;TargetScan;miRNATAP -0.106493543449922 2.02111667301054e-08 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-141-3p STC1 -5.02396127982626 2.19224509139725e-24 1.55340441030689 1.29077994156943e-05 miRNATAP -0.245072762381181 3.11072307709133e-14 NA NA NA hsa-miR-141-3p STX2 -5.02396127982626 2.19224509139725e-24 1.46584536494264 3.15752373756677e-06 MirTarget;TargetScan;miRNATAP -0.386796171821318 7.33479157194817e-50 NA NA NA hsa-miR-141-3p STXBP1 -5.02396127982626 2.19224509139725e-24 1.49894536197603 7.34819776156856e-06 MirTarget;TargetScan;miRNATAP -0.318342374652401 1.56294526587707e-27 NA NA NA hsa-miR-141-3p SULF2 -5.02396127982626 2.19224509139725e-24 0.318781799553762 0.520788272909573 MirTarget -0.375606637925405 1.72800283086241e-17 NA NA NA hsa-miR-141-3p SV2B -5.02396127982626 2.19224509139725e-24 2.33341367960543 7.07116491599067e-05 MirTarget -0.545453418281659 3.24619539940022e-26 NA NA NA hsa-miR-141-3p SVIL -5.02396127982626 2.19224509139725e-24 2.03948426821405 7.95203036996406e-13 miRNATAP -0.254445990921425 3.82583157040091e-23 NA NA NA hsa-miR-141-3p SYNPO2 -5.02396127982626 2.19224509139725e-24 5.28154477225055 4.72834649465789e-23 TargetScan;miRNATAP -0.615747260821091 3.09163015048226e-38 NA NA NA hsa-miR-141-3p TBC1D16 -5.02396127982626 2.19224509139725e-24 0.000723386575429696 0.997052256137852 mirMAP -0.108313975787591 9.92125850639723e-10 NA NA NA hsa-miR-141-3p TCF21 -5.02396127982626 2.19224509139725e-24 4.43944664880256 2.7674316320581e-24 TargetScan -0.306185746628777 1.9209178624363e-13 NA NA NA hsa-miR-141-3p TCF4 -5.02396127982626 2.19224509139725e-24 1.61270531688003 6.60474190579887e-09 MirTarget;TargetScan;miRNATAP -0.304690886225458 4.13552081488736e-37 NA NA NA hsa-miR-141-3p TCF7L1 -5.02396127982626 2.19224509139725e-24 1.29563210038614 0.000221106899905655 miRNAWalker2_validate -0.292690799524826 5.33572896586791e-21 NA NA NA hsa-miR-141-3p TEAD1 -5.02396127982626 2.19224509139725e-24 1.49495998391161 1.96516757915298e-13 mirMAP -0.187805911792407 8.82877169341974e-25 NA NA NA hsa-miR-141-3p TGFB2 -5.02396127982626 2.19224509139725e-24 1.19931727990522 0.00330886829654417 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-141-3p THSD4 -5.02396127982626 2.19224509139725e-24 2.37339687749734 3.92006931404179e-13 MirTarget -0.192965155028483 2.59747813165281e-10 NA NA NA hsa-miR-141-3p THSD7A -5.02396127982626 2.19224509139725e-24 1.95966066744565 2.0548196242739e-05 TargetScan -0.307455997998184 1.83199358211831e-13 NA NA NA hsa-miR-141-3p TLN2 -5.02396127982626 2.19224509139725e-24 1.13678695432202 2.3716498245972e-06 TargetScan -0.133980397958337 1.39258991252499e-09 NA NA NA hsa-miR-141-3p TMEFF1 -5.02396127982626 2.19224509139725e-24 -0.0710507292015876 0.799522125765306 MirTarget -0.149910716942084 3.56296039416296e-09 NA NA NA hsa-miR-141-3p TMEM108 -5.02396127982626 2.19224509139725e-24 2.78114300571125 1.45650573276381e-06 mirMAP -0.462799291214587 4.10868332497736e-19 NA NA NA hsa-miR-141-3p TMEM130 -5.02396127982626 2.19224509139725e-24 1.78163356079971 0.000643193183477071 MirTarget;TargetScan -0.334289571290283 1.63725866480439e-12 NA NA NA hsa-miR-141-3p TMEM170B -5.02396127982626 2.19224509139725e-24 0.889417316317812 0.00246966185092233 MirTarget;TargetScan;miRNATAP -0.132246513471541 9.57444558729234e-07 NA NA NA hsa-miR-141-3p TNFAIP3 -5.02396127982626 2.19224509139725e-24 1.62509801593269 1.60292614188531e-06 TargetScan -0.222404109517195 5.77674703240202e-13 NA NA NA hsa-miR-141-3p TNIK -5.02396127982626 2.19224509139725e-24 2.15489908889994 1.58503169822863e-07 TargetScan -0.221273329247466 5.5726038708684e-09 NA NA NA hsa-miR-141-3p TNRC6C -5.02396127982626 2.19224509139725e-24 1.19322170447823 2.76418571357646e-08 TargetScan;mirMAP -0.115377463729981 6.13721579740595e-09 NA NA NA hsa-miR-141-3p TNS1 -5.02396127982626 2.19224509139725e-24 3.79443812838711 2.14081599635661e-21 MirTarget;TargetScan -0.529205503273538 1.76374374915486e-54 NA NA NA hsa-miR-141-3p TNS3 -5.02396127982626 2.19224509139725e-24 0.103104493452803 0.668815191833339 MirTarget;TargetScan;miRNATAP -0.117250884574246 9.22998466951585e-08 NA NA NA hsa-miR-141-3p TRAM2 -5.02396127982626 2.19224509139725e-24 0.480560165227073 0.0151980825679311 MirTarget;TargetScan -0.200979225734952 2.00920794817633e-32 NA NA NA hsa-miR-141-3p TSHZ3 -5.02396127982626 2.19224509139725e-24 2.3826164042391 2.29782206551949e-10 MirTarget;TargetScan;miRNATAP -0.448354771292657 5.57469367444821e-45 NA NA NA hsa-miR-141-3p TSPAN4 -5.02396127982626 2.19224509139725e-24 1.20536056884068 4.07284626770108e-05 TargetScan -0.330035805169462 2.97467780076062e-40 NA NA NA hsa-miR-141-3p TTBK2 -5.02396127982626 2.19224509139725e-24 1.27061033500643 8.20749802166793e-07 MirTarget -0.139297581650302 4.35213465937124e-09 NA NA NA hsa-miR-141-3p TTC28 -5.02396127982626 2.19224509139725e-24 1.4343015117923 3.92866321975566e-07 TargetScan -0.128689284653316 9.22590583489215e-07 NA NA NA hsa-miR-141-3p TTLL7 -5.02396127982626 2.19224509139725e-24 2.52056504173714 1.06526045035506e-07 MirTarget;TargetScan -0.339365664154721 3.49014676599148e-15 NA NA NA hsa-miR-141-3p TTYH2 -5.02396127982626 2.19224509139725e-24 1.237079098584 0.000499317051106926 TargetScan;miRNATAP -0.324531910641359 2.04005153817933e-25 NA NA NA hsa-miR-141-3p UACA -5.02396127982626 2.19224509139725e-24 0.184212642048498 0.302812191960561 TargetScan -0.103079751074141 1.76101840320328e-10 NA NA NA hsa-miR-141-3p UNC5C -5.02396127982626 2.19224509139725e-24 2.85842438529154 7.1455313233325e-10 MirTarget;TargetScan -0.490431587291333 6.36258343774736e-34 NA NA NA hsa-miR-141-3p VCAN -5.02396127982626 2.19224509139725e-24 -0.102699847387801 0.827138258538124 MirTarget;TargetScan;miRNATAP -0.368944305303294 8.18079315504103e-19 NA NA NA hsa-miR-141-3p WDFY4 -5.02396127982626 2.19224509139725e-24 1.52835958077685 0.00208595788951406 mirMAP -0.442972356362165 3.04952593629735e-24 NA NA NA hsa-miR-141-3p WDR31 -5.02396127982626 2.19224509139725e-24 0.638768153831783 0.0652199978514124 TargetScan -0.103964375098238 0.0011483530328461 NA NA NA hsa-miR-141-3p WDR44 -5.02396127982626 2.19224509139725e-24 0.618746968114831 0.00104356284659584 MirTarget;miRNATAP -0.100755126448433 4.90681812652661e-09 NA NA NA hsa-miR-141-3p WIPF1 -5.02396127982626 2.19224509139725e-24 1.36396473341553 1.25828143739991e-05 MirTarget;TargetScan;miRNATAP -0.370961510650937 6.77544747234292e-46 NA NA NA hsa-miR-141-3p WWC2 -5.02396127982626 2.19224509139725e-24 0.762253212847518 0.00511431449708868 mirMAP -0.180337214768461 2.04755740891876e-13 NA NA NA hsa-miR-141-3p WWTR1 -5.02396127982626 2.19224509139725e-24 1.56733544291317 4.7313416502979e-08 MirTarget;TargetScan;miRNATAP -0.305882494344842 5.69456849157899e-35 NA NA NA hsa-miR-210-3p XIST -6.07079758655679 2.22120227133377e-28 2.3960794008542 0.0565558740952363 miRTarBase -0.273614152195619 0.00806042955759993 NA NA NA hsa-miR-141-3p YAP1 -5.02396127982626 2.19224509139725e-24 0.819514922156016 7.72909626929216e-05 MirTarget;TargetScan -0.107645543722487 1.48207382564769e-08 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-141-3p ZBED3 -5.02396127982626 2.19224509139725e-24 0.907237805146047 0.00377148523945498 mirMAP -0.122256821649953 2.2748260545844e-05 NA NA NA hsa-miR-141-3p ZBTB16 -5.02396127982626 2.19224509139725e-24 4.69496897387157 4.31130951508901e-16 TargetScan -0.48291304862009 8.49491749838432e-20 NA NA NA hsa-miR-141-3p ZBTB20 -5.02396127982626 2.19224509139725e-24 1.43804710029372 8.52102753381246e-08 MirTarget;TargetScan -0.122693460125016 8.66598183953896e-07 NA NA NA hsa-miR-141-3p ZBTB46 -5.02396127982626 2.19224509139725e-24 0.658672030651982 0.00845543054081283 TargetScan -0.149961532692541 3.73107001017367e-11 NA NA NA hsa-miR-141-3p ZCCHC24 -5.02396127982626 2.19224509139725e-24 2.70719377368971 1.38525107553658e-17 MirTarget;TargetScan;miRNATAP -0.430649507462384 8.6364775253421e-60 NA NA NA hsa-miR-141-3p ZDHHC15 -5.02396127982626 2.19224509139725e-24 2.821890119317 1.80193983474818e-08 MirTarget -0.377496799271016 1.03308793727144e-16 NA NA NA hsa-miR-141-3p ZEB1 -5.02396127982626 2.19224509139725e-24 2.59416392469398 4.19342616481448e-16 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.454590307809987 3.89274905091345e-69 24424572;24307282;26783187 Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;drug resistance head and neck cancer;sarcoma;lung squamous cell cancer hsa-miR-141-3p ZEB2 -5.02396127982626 2.19224509139725e-24 2.26388876645177 1.13775147583663e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.457292723841066 1.19552890420513e-72 25975736;18925646;24307282 These results suggest that miR‑141 may be involved in the inhibition of gastric cancer cell migration and that ZEB2 is a target gene of miR-141;TargetScan algorithm revealed that ZFHX1B mRNA is a hypothetical target of both miR-141 and -200c; We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2 cell migration;; gastric cancer;kidney renal cell cancer;sarcoma hsa-miR-141-3p ZFP37 -5.02396127982626 2.19224509139725e-24 0.810062916275531 0.0701924167642926 mirMAP -0.107785073955837 0.00921515771520328 NA NA NA hsa-miR-141-3p ZFPM2 -5.02396127982626 2.19224509139725e-24 3.29884457958358 4.34537841593156e-12 miRNAWalker2_validate;miRTarBase -0.591845819504785 3.53269529968965e-49 NA NA NA hsa-miR-141-3p ZNF281 -5.02396127982626 2.19224509139725e-24 -0.0416620203780274 0.888110347621827 TargetScan -0.13170223961539 1.13014383161302e-06 NA NA NA hsa-miR-141-3p ZNF385D -5.02396127982626 2.19224509139725e-24 2.94693702740533 2.33707811164883e-08 MirTarget;TargetScan -0.448822778764785 2.25888897773164e-21 NA NA NA hsa-miR-141-3p ZNF423 -5.02396127982626 2.19224509139725e-24 1.58042037965747 5.91645417503194e-05 mirMAP -0.13618213127291 0.000192788876232564 NA NA NA hsa-miR-210-3p ZNF462 -6.07079758655679 2.22120227133377e-28 1.2376798239588 0.000429235196584823 MirTarget -0.111452041715297 0.000113721250476468 NA NA NA hsa-miR-141-3p ZNF516 -5.02396127982626 2.19224509139725e-24 1.70455112707834 2.41525896684442e-07 TargetScan;miRNATAP -0.147891193929967 1.39933363976451e-06 NA NA NA hsa-miR-141-3p ZNF660 -5.02396127982626 2.19224509139725e-24 1.61536224802332 5.42520418912947e-05 TargetScan -0.155368632021419 2.77427383649447e-05 NA NA NA