miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-16-5p AADAT 0.468459442059375 0.02635007201346 -0.430821792780901 0.0749760085183994 miRNAWalker2_validate -0.280137487754655 5.84024636391147e-05 NA NA NA hsa-miR-16-5p ABCB5 0.468459442059375 0.02635007201346 -0.955542170385081 0.040765415736202 MirTarget -1.05952901960627 1.61605815421718e-16 NA NA NA hsa-miR-16-5p ABCC1 0.468459442059375 0.02635007201346 0.338085547833431 0.00383599185957183 miRNAWalker2_validate -0.101120807811114 0.00289539760508998 NA NA NA hsa-miR-16-5p ABL1 0.468459442059375 0.02635007201346 -0.214581652674921 0.0780394697492818 mirMAP -0.249348604550532 1.41526789822687e-13 NA NA NA hsa-miR-16-5p ABL2 0.468459442059375 0.02635007201346 0.820053510414726 8.89463322803119e-15 miRNAWalker2_validate;MirTarget;miRNATAP -0.132667608646662 3.26719434988602e-05 NA NA NA hsa-miR-16-5p ABTB2 0.468459442059375 0.02635007201346 0.158887921869035 0.335857735487359 MirTarget -0.133515832577909 0.00518904886626496 NA NA NA hsa-miR-16-5p ACSBG1 0.468459442059375 0.02635007201346 -0.888245169055709 4.20985642335772e-05 MirTarget -0.570184734500668 3.70974891334774e-22 NA NA NA hsa-miR-16-5p ACTB 0.468459442059375 0.02635007201346 -0.247183413092236 0.0173597292223771 miRNAWalker2_validate -0.163077534767565 3.02541984850391e-08 NA NA NA hsa-miR-16-5p ACTN1 0.468459442059375 0.02635007201346 0.144220815927838 0.446062625714916 miRNAWalker2_validate -0.496262794307697 8.17814313065507e-23 NA NA NA hsa-miR-16-5p ACVR2A 0.468459442059375 0.02635007201346 -0.409014715537696 0.000390733013426116 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.203956484766576 4.34784957003667e-10 NA NA NA hsa-miR-16-5p ACVR2B 0.468459442059375 0.02635007201346 0.479263794953631 0.00365312140717121 miRNATAP -0.118677280753533 0.0136650480876575 NA NA NA hsa-miR-16-5p ADAMTS18 0.468459442059375 0.02635007201346 3.26280400969973 2.5262880435359e-19 miRNATAP -0.244639532435864 0.031330974118321 NA NA NA hsa-miR-16-5p ADAMTS3 0.468459442059375 0.02635007201346 0.381745529837852 0.0472261904397674 miRNATAP -0.310967057841851 1.21719782464708e-08 NA NA NA hsa-miR-16-5p ADAMTS5 0.468459442059375 0.02635007201346 0.188190214805037 0.2771550462378 miRNATAP -0.276019274614413 1.78676682565846e-08 NA NA NA hsa-miR-16-5p ADAMTSL3 0.468459442059375 0.02635007201346 -1.55905070705917 3.51494202991297e-06 MirTarget -0.861071644619396 1.11665113322294e-20 NA NA NA hsa-miR-16-5p ADCY2 0.468459442059375 0.02635007201346 -1.52957881268437 3.68996645479601e-05 mirMAP -1.02767333801464 6.45758028734737e-25 NA NA NA hsa-miR-16-5p ADCY5 0.468459442059375 0.02635007201346 -1.84103992569989 1.33834751194577e-05 MirTarget;miRNATAP -1.1904608544884 1.04626295432719e-25 NA NA NA hsa-miR-16-5p ADRB2 0.468459442059375 0.02635007201346 -2.77607289745493 7.42075616046658e-20 MirTarget -0.450687263710372 1.55189001320559e-06 NA NA NA hsa-miR-16-5p AFF4 0.468459442059375 0.02635007201346 -0.266238435778205 0.0156473179650327 MirTarget;miRNATAP -0.214131383476994 3.16136929955011e-12 NA NA NA hsa-miR-16-5p AGPAT4 0.468459442059375 0.02635007201346 0.0930866987009771 0.613205838182191 mirMAP -0.400692797765968 2.46049373939322e-15 NA NA NA hsa-miR-16-5p AHNAK2 0.468459442059375 0.02635007201346 -0.5905150352765 0.13881539538977 miRNAWalker2_validate -1.14283786958369 8.50462998869559e-28 NA NA NA hsa-miR-16-5p AK4 0.468459442059375 0.02635007201346 -1.11655840159903 0.00017402069474046 MirTarget;miRNATAP -0.470818238052336 3.5996740819749e-08 NA NA NA hsa-miR-16-5p AKAP11 0.468459442059375 0.02635007201346 0.196284041245934 0.098252789597144 MirTarget;miRNATAP -0.18900776980321 1.78186556840174e-08 NA NA NA hsa-miR-16-5p AKT3 0.468459442059375 0.02635007201346 -0.273001052722672 0.188651193580836 miRNAWalker2_validate;miRTarBase;miRNATAP -0.568045037958797 4.87003529234726e-25 NA NA NA hsa-miR-16-5p AMOTL1 0.468459442059375 0.02635007201346 -0.486379931315175 0.054603870149297 MirTarget;miRNATAP -0.655033423559791 5.60952749818319e-22 NA NA NA hsa-miR-16-5p ANAPC16 0.468459442059375 0.02635007201346 -0.562573593594966 5.30708721594642e-08 miRNAWalker2_validate -0.133403180798246 1.05663603834152e-05 NA NA NA hsa-miR-16-5p ANK2 0.468459442059375 0.02635007201346 -1.60257109400243 5.33587507985444e-06 MirTarget;miRNATAP -1.02543043080236 9.68151112455906e-28 NA NA NA hsa-miR-16-5p ANKRD29 0.468459442059375 0.02635007201346 -1.34789320693404 8.2268003911958e-06 MirTarget -0.510116331142788 4.52471494130292e-09 NA NA NA hsa-miR-16-5p ANKS1A 0.468459442059375 0.02635007201346 -0.13350994800444 0.229491244188813 MirTarget -0.263875693618492 1.69093884989013e-18 NA NA NA hsa-miR-16-5p ANO3 0.468459442059375 0.02635007201346 -0.681632892778825 0.155509818355017 MirTarget;miRNATAP -0.279606945485908 0.0455326677329417 NA NA NA hsa-miR-16-5p AR 0.468459442059375 0.02635007201346 -1.55428586679464 3.79681953414866e-06 mirMAP;miRNATAP -0.985299423793118 4.0929212877286e-28 NA NA NA hsa-miR-16-5p ARHGAP20 0.468459442059375 0.02635007201346 -1.37521379031409 6.54964322003788e-07 MirTarget;miRNATAP -0.749706268759072 2.49972574018994e-23 NA NA NA hsa-miR-16-5p ARHGAP5 0.468459442059375 0.02635007201346 -0.123874599542773 0.263036005478456 MirTarget;miRNATAP -0.208724281495104 1.24890444391077e-11 NA NA NA hsa-miR-16-5p ARHGEF12 0.468459442059375 0.02635007201346 0.0895782409826751 0.356931527604922 MirTarget -0.169069719593881 5.05897920487556e-10 NA NA NA hsa-miR-16-5p ARHGEF9 0.468459442059375 0.02635007201346 -0.626478540461318 1.70542084501607e-07 miRNATAP -0.229852556109099 1.91276185584546e-11 NA NA NA hsa-miR-16-5p ARIH1 0.468459442059375 0.02635007201346 0.0230997107313007 0.793468726040202 MirTarget -0.124231973860522 6.28916792792315e-07 NA NA NA hsa-miR-16-5p ARL10 0.468459442059375 0.02635007201346 -0.28129009619869 0.198316212901093 miRNAWalker2_validate -0.49022807682267 3.0821964200579e-16 NA NA NA hsa-miR-16-5p ARL3 0.468459442059375 0.02635007201346 -0.521628086406404 2.45297123307517e-07 miRNAWalker2_validate;MirTarget -0.117945656861165 6.78184953395905e-05 NA NA NA hsa-miR-16-5p ARL8B 0.468459442059375 0.02635007201346 -0.208090655274296 0.0111650980017705 MirTarget;miRNATAP -0.16107193656259 1.41608120676058e-12 NA NA NA hsa-miR-16-5p ARMCX2 0.468459442059375 0.02635007201346 -0.772079447220427 0.00112319033532053 miRNAWalker2_validate;MirTarget;miRNATAP -0.534759640458762 3.65784441596427e-16 NA NA NA hsa-miR-16-5p ARNT2 0.468459442059375 0.02635007201346 -0.332178452162526 0.258506029820392 mirMAP -0.257436814504623 0.00249497162104775 NA NA NA hsa-miR-16-5p ARVCF 0.468459442059375 0.02635007201346 0.320195968561741 0.0554679301005034 mirMAP -0.272537126201118 8.69654732981037e-09 NA NA NA hsa-miR-16-5p ASB1 0.468459442059375 0.02635007201346 -0.275456210497773 0.00868427409528013 MirTarget -0.208201865313652 1.05281754015906e-12 NA NA NA hsa-miR-16-5p ASH1L 0.468459442059375 0.02635007201346 0.106845282951007 0.300475098931278 miRNAWalker2_validate;MirTarget;miRNATAP -0.203737909252467 9.85099715433403e-13 NA NA NA hsa-miR-16-5p ASTN1 0.468459442059375 0.02635007201346 -2.38850445662267 1.79346320545124e-05 MirTarget -1.23133459556003 3.02139035164133e-15 NA NA NA hsa-miR-16-5p ATF7 0.468459442059375 0.02635007201346 0.0674049536109402 0.438061225007579 miRNAWalker2_validate -0.21963798681548 2.29549682421675e-21 NA NA NA hsa-miR-16-5p ATG14 0.468459442059375 0.02635007201346 0.00414748208186211 0.968361225112142 miRNAWalker2_validate;MirTarget;miRNATAP -0.274272248431266 4.2565184346948e-23 NA NA NA hsa-miR-16-5p ATL2 0.468459442059375 0.02635007201346 -0.383786242998031 0.000575339633888933 miRNAWalker2_validate -0.246662461946968 1.23832748375884e-15 NA NA NA hsa-miR-16-5p ATP2B2 0.468459442059375 0.02635007201346 -1.88676051504383 8.01381000058104e-07 MirTarget;miRNATAP -0.944911794883119 5.0949915963447e-19 NA NA NA hsa-miR-16-5p ATP7A 0.468459442059375 0.02635007201346 -0.238505552773791 0.0260565224422086 MirTarget -0.124730189396658 5.02699863468193e-05 NA NA NA hsa-miR-16-5p ATP8A2 0.468459442059375 0.02635007201346 -1.33015281704727 6.49693770892505e-06 miRNAWalker2_validate -0.306700274688815 0.000402984823107497 NA NA NA hsa-miR-16-5p ATXN1L 0.468459442059375 0.02635007201346 -0.0692838660654802 0.432409698959029 miRNATAP -0.135821153329364 4.53294795135525e-08 NA NA NA hsa-miR-16-5p ATXN2 0.468459442059375 0.02635007201346 0.266571196061886 0.000720671732750195 MirTarget;miRNATAP -0.143990113891277 7.31762297823942e-11 NA NA NA hsa-miR-16-5p ATXN7L1 0.468459442059375 0.02635007201346 0.0625942927803105 0.536526011070187 miRNATAP -0.148594689346963 2.11745216486272e-07 NA NA NA hsa-miR-16-5p BACE1 0.468459442059375 0.02635007201346 -0.0959250699806233 0.497546427155974 miRNATAP -0.3594907084583 2.2377182933401e-21 NA NA NA hsa-miR-16-5p BACH2 0.468459442059375 0.02635007201346 -0.153664361619301 0.559092317470499 MirTarget;miRNATAP -0.340532453947548 6.08196941316752e-06 NA NA NA hsa-miR-16-5p BCAP29 0.468459442059375 0.02635007201346 -0.0906430310318083 0.291870498841624 MirTarget -0.173579000373952 2.25282528047e-13 NA NA NA hsa-miR-16-5p BCL2 0.468459442059375 0.02635007201346 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.307544967095245 3.1475788390589e-08 18449891;21336967;24447552;25435430;24598659;18931683;22966344;25623762 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells drug resistance;;worse prognosis;;;;poor survival;drug resistance gastric cancer;liver cancer;lymphoma;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-16-5p BHLHE41 0.468459442059375 0.02635007201346 0.353158422209973 0.127533936542101 miRNATAP -0.344034917459229 1.87223392946303e-07 NA NA NA hsa-miR-16-5p BMX 0.468459442059375 0.02635007201346 -1.36301267548465 7.13244454182066e-07 MirTarget;miRNATAP -0.407217600906153 3.69297279393485e-07 NA NA NA hsa-miR-16-5p BNC2 0.468459442059375 0.02635007201346 -0.491277997679328 0.0998827438687705 miRNAWalker2_validate -0.898406159402283 2.60986571280855e-31 NA NA NA hsa-miR-16-5p BRD3 0.468459442059375 0.02635007201346 0.370170558391524 0.000130397685151564 mirMAP -0.148289195188777 8.36907729000765e-08 NA NA NA hsa-miR-16-5p BRSK2 0.468459442059375 0.02635007201346 0.550284260209954 0.140186259420255 mirMAP -0.446959707194828 3.11735687082285e-05 NA NA NA hsa-miR-16-5p BTBD19 0.468459442059375 0.02635007201346 0.961835296568945 1.05703169179008e-07 mirMAP -0.365774639665989 1.41404644908627e-12 NA NA NA hsa-miR-16-5p BTG2 0.468459442059375 0.02635007201346 -1.7630923979864 5.46944077014254e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.266776184014457 3.46585254910816e-05 NA NA NA hsa-miR-16-5p BTRC 0.468459442059375 0.02635007201346 -0.027346328507087 0.741734122686342 miRNAWalker2_validate;MirTarget;miRNATAP -0.132845602675406 1.10929984506892e-08 NA NA NA hsa-miR-16-5p BVES 0.468459442059375 0.02635007201346 -1.51355443880608 7.967744286549e-06 MirTarget -1.01835817045583 5.66667206777867e-30 NA NA NA hsa-miR-16-5p C15orf52 0.468459442059375 0.02635007201346 -0.7749934427518 0.00649279666461122 mirMAP -0.849896235533607 2.29013957230419e-30 NA NA NA hsa-miR-16-5p C16orf52 0.468459442059375 0.02635007201346 -0.0740715490056836 0.385096294799324 miRNATAP -0.182843065520508 4.18801742102868e-15 NA NA NA hsa-miR-16-5p C1orf21 0.468459442059375 0.02635007201346 -0.727977288966725 9.22717896803663e-05 mirMAP;miRNATAP -0.383195206876469 2.47539170875658e-13 NA NA NA hsa-miR-16-5p CACNA1E 0.468459442059375 0.02635007201346 1.7522562120673 4.35724222478899e-06 MirTarget -0.234073656757333 0.03848542976049 NA NA NA hsa-miR-16-5p CACNA2D1 0.468459442059375 0.02635007201346 -0.846445244760543 0.00675290229856498 miRNAWalker2_validate -0.79692949831392 4.34578947666631e-21 NA NA NA hsa-miR-16-5p CACNB2 0.468459442059375 0.02635007201346 -1.05668882228159 0.000454628609880799 miRNAWalker2_validate -0.954622658386906 7.74339910759152e-35 NA NA NA hsa-miR-16-5p CACNB4 0.468459442059375 0.02635007201346 -1.05630266128413 0.000199554767655941 miRNATAP -0.566117558300052 1.57254557372925e-12 NA NA NA hsa-miR-16-5p CADM1 0.468459442059375 0.02635007201346 -0.899936241890849 0.000844138987328649 miRNAWalker2_validate;miRTarBase;miRNATAP -0.318970685413952 4.56350601031325e-05 NA NA NA hsa-miR-16-5p CALM1 0.468459442059375 0.02635007201346 -0.784429149792681 2.03164806777006e-14 miRNATAP -0.171866818558949 1.74349198269888e-08 NA NA NA hsa-miR-16-5p CALU 0.468459442059375 0.02635007201346 0.67344582166522 5.97080259757143e-10 miRNAWalker2_validate;MirTarget -0.105790725880547 0.00109561188859313 NA NA NA hsa-miR-16-5p CAMK2G 0.468459442059375 0.02635007201346 -0.531707953024434 0.000413134284231954 miRNAWalker2_validate -0.43553950276555 5.59199309165606e-28 NA NA NA hsa-miR-16-5p CAMKV 0.468459442059375 0.02635007201346 0.365121683149714 0.438369214703988 miRNAWalker2_validate;miRNATAP -0.286988880484916 0.0362399238842228 NA NA NA hsa-miR-16-5p CAMSAP1 0.468459442059375 0.02635007201346 0.244651879709817 0.0399081942272141 miRNAWalker2_validate;MirTarget;miRNATAP -0.100783078211527 0.00343987552546894 NA NA NA hsa-miR-16-5p CAMSAP2 0.468459442059375 0.02635007201346 0.423832054082736 0.000532909035924399 miRNATAP -0.285480917484414 2.10743816561263e-17 NA NA NA hsa-miR-16-5p CAPN6 0.468459442059375 0.02635007201346 -1.28977859948282 0.0253718872051572 miRNATAP -0.638494602791968 0.000130246849285373 NA NA NA hsa-miR-16-5p CAPZA2 0.468459442059375 0.02635007201346 -0.190566573954487 0.0877745932002987 miRNAWalker2_validate;MirTarget -0.157846729381732 6.61893330390989e-07 NA NA NA hsa-miR-16-5p CASZ1 0.468459442059375 0.02635007201346 -0.74282009313037 2.13443263629592e-07 MirTarget -0.166150699323537 7.97121217162626e-05 NA NA NA hsa-miR-16-5p CBFA2T3 0.468459442059375 0.02635007201346 -1.22133105486193 6.89171725275405e-06 MirTarget;miRNATAP -0.256721061592604 0.00132481744030849 NA NA NA hsa-miR-16-5p CBL 0.468459442059375 0.02635007201346 0.291219247177072 0.0126694723519977 mirMAP -0.132618655025389 8.0467085962383e-05 NA NA NA hsa-miR-16-5p CBX5 0.468459442059375 0.02635007201346 0.164944902002406 0.244455396933291 miRNATAP -0.111820920776524 0.00637878833693296 NA NA NA hsa-miR-16-5p CCDC144A 0.468459442059375 0.02635007201346 -0.223988875692845 0.668368573068086 mirMAP -0.475420993447929 0.00166912835231612 NA NA NA hsa-miR-16-5p CCDC149 0.468459442059375 0.02635007201346 -0.520398436583311 0.00235869791503379 MirTarget -0.254465652422519 2.09506822425464e-07 NA NA NA hsa-miR-16-5p CCDC6 0.468459442059375 0.02635007201346 0.270451325546948 0.0255492648029981 MirTarget;miRNATAP -0.162733116358977 2.61122495672883e-06 NA NA NA hsa-miR-16-5p CCND2 0.468459442059375 0.02635007201346 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRNATAP -0.516132357400658 2.11146706317975e-12 NA NA NA hsa-miR-16-5p CCPG1 0.468459442059375 0.02635007201346 -0.206345981982444 0.045354236212813 miRNAWalker2_validate -0.13131185205609 8.29075568089282e-06 NA NA NA hsa-miR-16-5p CD44 0.468459442059375 0.02635007201346 0.22322903953021 0.302952719713054 miRNAWalker2_validate -0.178229991933679 0.00451403769175094 NA NA NA hsa-miR-16-5p CDADC1 0.468459442059375 0.02635007201346 -0.175403878216009 0.0980480368715214 miRNAWalker2_validate -0.118755960636389 9.36053955679181e-05 NA NA NA hsa-miR-16-5p CDC37L1 0.468459442059375 0.02635007201346 -0.427242848422614 9.3988336440429e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.147579612809277 2.91353099764126e-06 NA NA NA hsa-miR-16-5p CDK17 0.468459442059375 0.02635007201346 0.0694540025336501 0.487075282749813 miRNAWalker2_validate;MirTarget;miRNATAP -0.225546949169 1.06971275230007e-16 NA NA NA hsa-miR-16-5p CDS2 0.468459442059375 0.02635007201346 -0.264082281986768 0.0124768267475766 miRNAWalker2_validate;mirMAP;miRNATAP -0.241895356509056 5.77962287961018e-17 NA NA NA hsa-miR-16-5p CEP63 0.468459442059375 0.02635007201346 -0.0968385672273597 0.218950942044022 miRNAWalker2_validate -0.136269506694957 5.44068188490879e-10 NA NA NA hsa-miR-16-5p CFL2 0.468459442059375 0.02635007201346 -1.29748949709607 2.10137209702745e-06 miRNAWalker2_validate -0.82612686830472 3.39764783290628e-30 NA NA NA hsa-miR-16-5p CHD3 0.468459442059375 0.02635007201346 -0.00056985963877132 0.99669087955822 miRNAWalker2_validate -0.161264269513139 4.1409387796195e-05 NA NA NA hsa-miR-16-5p CHD5 0.468459442059375 0.02635007201346 -0.922474137133441 0.0152054367268636 miRNATAP -0.935333083145399 1.45074346804214e-19 NA NA NA hsa-miR-16-5p CHD9 0.468459442059375 0.02635007201346 -0.255057088271817 0.0209229203314752 miRNATAP -0.256591587346628 1.60568056124898e-17 NA NA NA hsa-miR-16-5p CLASP1 0.468459442059375 0.02635007201346 0.0864210099182321 0.350450750205728 miRNAWalker2_validate -0.197384595525743 6.80566548027004e-15 NA NA NA hsa-miR-16-5p CLOCK 0.468459442059375 0.02635007201346 -0.103747140891207 0.347345002981963 MirTarget -0.134620428300819 1.95177787953249e-05 NA NA NA hsa-miR-16-5p CNKSR2 0.468459442059375 0.02635007201346 -1.84738040911148 0.000144389883049721 miRNATAP -1.33020798427442 2.6065224941877e-24 NA NA NA hsa-miR-16-5p CNN1 0.468459442059375 0.02635007201346 -2.63261128854596 3.50101583516012e-07 miRNATAP -1.52686367670466 2.30577538418923e-28 NA NA NA hsa-miR-16-5p CNN3 0.468459442059375 0.02635007201346 -0.562615101587786 0.000315898705221665 miRNAWalker2_validate -0.26700016498424 1.97939451512183e-09 NA NA NA hsa-miR-16-5p CNTNAP1 0.468459442059375 0.02635007201346 0.357666658494201 0.137267058981739 MirTarget -0.604306186330414 1.2840945307249e-20 NA NA NA hsa-miR-16-5p COL12A1 0.468459442059375 0.02635007201346 1.85024755694303 1.80226749421741e-14 MirTarget;miRNATAP -0.324085442655662 8.97521325308437e-06 NA NA NA hsa-miR-16-5p COL24A1 0.468459442059375 0.02635007201346 0.0627518396785927 0.830857580241174 MirTarget;miRNATAP -0.592549955561772 3.78332331123896e-13 NA NA NA hsa-miR-16-5p COL4A1 0.468459442059375 0.02635007201346 1.78756439655909 1.15160259120415e-19 miRNAWalker2_validate -0.154435330020513 0.0121553308385016 NA NA NA hsa-miR-16-5p COL4A2 0.468459442059375 0.02635007201346 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate -0.282823841850533 5.33266269478467e-07 NA NA NA hsa-miR-16-5p COL4A3BP 0.468459442059375 0.02635007201346 -0.442702454360006 7.43848955821672e-07 MirTarget;miRNATAP -0.161233498725285 2.64526714343472e-10 NA NA NA hsa-miR-16-5p COL4A4 0.468459442059375 0.02635007201346 0.203566165779439 0.562717703881247 mirMAP -0.439780736121142 1.2927402552007e-05 NA NA NA hsa-miR-16-5p COLQ 0.468459442059375 0.02635007201346 -0.0281705177858252 0.88881327375582 MirTarget -0.388007488481874 4.89227433526505e-12 NA NA NA hsa-miR-16-5p COPS2 0.468459442059375 0.02635007201346 -0.177690858514008 0.0497397118986118 MirTarget -0.132268336558853 2.53002060336263e-07 NA NA NA hsa-miR-16-5p CPEB2 0.468459442059375 0.02635007201346 -0.814992840745196 1.51604703202433e-10 miRNATAP -0.291375379714284 8.29731963129453e-16 NA NA NA hsa-miR-16-5p CPEB3 0.468459442059375 0.02635007201346 -0.726462801367756 6.97488351116509e-10 MirTarget;miRNATAP -0.186506027897577 6.47981733388126e-08 NA NA NA hsa-miR-16-5p CPNE8 0.468459442059375 0.02635007201346 0.0062044767507774 0.974298258402277 miRNAWalker2_validate -0.37587275763501 2.32803003731012e-12 NA NA NA hsa-miR-16-5p CREB3L2 0.468459442059375 0.02635007201346 -0.525060002905056 1.65437910930531e-05 miRNAWalker2_validate -0.183482969404046 1.770961248215e-07 NA NA NA hsa-miR-16-5p CREB5 0.468459442059375 0.02635007201346 0.0144734137836222 0.953004773309416 miRNATAP -0.43058273916855 4.50409890129185e-10 NA NA NA hsa-miR-16-5p CREBL2 0.468459442059375 0.02635007201346 -0.289272671162855 0.00289044434753105 miRNAWalker2_validate -0.143426374227248 2.1685555972751e-07 NA NA NA hsa-miR-16-5p CREBRF 0.468459442059375 0.02635007201346 -0.366122742256368 0.00726639317725131 MirTarget;miRNATAP -0.41164232353014 1.89116167943136e-31 NA NA NA hsa-miR-16-5p CRHBP 0.468459442059375 0.02635007201346 -1.86592532904734 1.09075192248574e-08 miRNAWalker2_validate -0.503409137223867 1.43052642786584e-07 NA NA NA hsa-miR-16-5p CRIM1 0.468459442059375 0.02635007201346 0.197285946805334 0.189438220015135 MirTarget;miRNATAP -0.305512614256775 2.30864747547938e-13 NA NA NA hsa-miR-16-5p CRTC3 0.468459442059375 0.02635007201346 0.163968910454066 0.167864898428982 miRNATAP -0.230112949866966 3.43021640166327e-12 NA NA NA hsa-miR-16-5p CSDE1 0.468459442059375 0.02635007201346 -0.493287553628065 9.33208346703344e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.221966869783644 4.7732039656455e-18 NA NA NA hsa-miR-16-5p CSGALNACT1 0.468459442059375 0.02635007201346 0.0158656866116087 0.920206408463859 miRNAWalker2_validate -0.192645298437882 2.14265610438092e-05 NA NA NA hsa-miR-16-5p CSRNP1 0.468459442059375 0.02635007201346 -1.44806555350895 9.29266738210502e-17 MirTarget -0.17385171503421 0.00117204764770798 NA NA NA hsa-miR-16-5p CSRNP2 0.468459442059375 0.02635007201346 0.2407958778036 0.00292801865987127 miRNATAP -0.110332846317089 1.72947665067787e-06 NA NA NA hsa-miR-16-5p CTDSPL 0.468459442059375 0.02635007201346 0.0846519426294803 0.451210027493253 miRNATAP -0.182132590228328 8.56014826161749e-09 NA NA NA hsa-miR-16-5p CYS1 0.468459442059375 0.02635007201346 -1.28136910647413 0.000362306307876932 mirMAP -0.942002015126119 3.69853776785707e-22 NA NA NA hsa-miR-16-5p DCAF5 0.468459442059375 0.02635007201346 -0.432022552798976 2.11919388779901e-08 MirTarget;miRNATAP -0.135523552150841 9.13147547748019e-10 NA NA NA hsa-miR-16-5p DCLK1 0.468459442059375 0.02635007201346 -1.32352503962546 0.000138162205768269 miRNATAP -0.839752683019201 1.61411711103512e-18 NA NA NA hsa-miR-16-5p DCUN1D4 0.468459442059375 0.02635007201346 -0.256427886046376 0.0215922527238607 MirTarget;miRNATAP -0.234210119034957 3.20741403405358e-14 NA NA NA hsa-miR-16-5p DCX 0.468459442059375 0.02635007201346 -0.844677817637489 0.10668674687843 mirMAP -0.992999060899347 1.33027051730101e-11 NA NA NA hsa-miR-16-5p DDHD2 0.468459442059375 0.02635007201346 -0.154583103342212 0.193842372532219 miRNAWalker2_validate -0.212804790810022 1.68958303130421e-10 NA NA NA hsa-miR-16-5p DDX3Y 0.468459442059375 0.02635007201346 -1.08011892315372 0.269270157228425 miRNAWalker2_validate;MirTarget;miRNATAP -0.66920952393031 0.0185771728362028 NA NA NA hsa-miR-16-5p DDX6 0.468459442059375 0.02635007201346 0.0909600078885502 0.364279387413942 miRNAWalker2_validate -0.209148556035941 3.26265217044136e-14 NA NA NA hsa-miR-16-5p DENND4A 0.468459442059375 0.02635007201346 0.0639973705197328 0.546412201539267 MirTarget -0.145583005879473 1.34590632926609e-06 NA NA NA hsa-miR-16-5p DEPTOR 0.468459442059375 0.02635007201346 -0.636660583221345 0.000625271809267951 MirTarget -0.117103900622873 0.0319818320732698 NA NA NA hsa-miR-16-5p DICER1 0.468459442059375 0.02635007201346 0.0423646248128726 0.674000051094903 miRNAWalker2_validate -0.108205280679886 0.000173309016346085 NA NA NA hsa-miR-16-5p DIXDC1 0.468459442059375 0.02635007201346 -1.16493051519743 1.82036516809915e-06 miRNAWalker2_validate;MirTarget -0.804235115488361 1.12228823615132e-37 NA NA NA hsa-miR-16-5p DLC1 0.468459442059375 0.02635007201346 -0.381837238292576 0.0503828744141603 miRNAWalker2_validate -0.468245704376486 1.16893028966203e-18 NA NA NA hsa-miR-16-5p DLL1 0.468459442059375 0.02635007201346 -0.367321557272473 0.0311156953180708 miRNATAP -0.140478660492966 0.00451926292143064 NA NA NA hsa-miR-16-5p DMD 0.468459442059375 0.02635007201346 -1.50584693629303 4.05157194167937e-06 miRNAWalker2_validate -0.988960775179143 2.00865789895759e-30 NA NA NA hsa-miR-16-5p DMTF1 0.468459442059375 0.02635007201346 0.248049933973103 0.0272588092258348 miRNAWalker2_validate;MirTarget;miRNATAP -0.121877150071894 0.000163687149650316 NA NA NA hsa-miR-16-5p DNAJA4 0.468459442059375 0.02635007201346 0.274133991463733 0.132162668434715 miRNAWalker2_validate -0.11717947112649 0.0268020149074682 NA NA NA hsa-miR-16-5p DNAJB4 0.468459442059375 0.02635007201346 -0.699790825105696 7.61829706903065e-06 miRNAWalker2_validate -0.451813321978953 2.00875649078104e-27 NA NA NA hsa-miR-16-5p DOCK4 0.468459442059375 0.02635007201346 0.502120813551762 0.00108492735386023 MirTarget -0.212377296652345 1.56092278704462e-06 NA NA NA hsa-miR-16-5p DOCK9 0.468459442059375 0.02635007201346 0.119962941828406 0.352682724173672 miRNAWalker2_validate -0.172788158672847 2.63379697296121e-06 NA NA NA hsa-miR-16-5p DRD1 0.468459442059375 0.02635007201346 0.226592195703944 0.647536682501484 MirTarget;miRNATAP -0.533775745013277 0.000185612046972112 NA NA NA hsa-miR-16-5p DSEL 0.468459442059375 0.02635007201346 -0.67285265642764 0.0053381936162325 MirTarget;miRNATAP -0.611023464127672 1.0078823744594e-20 NA NA NA hsa-miR-16-5p DUSP3 0.468459442059375 0.02635007201346 -0.535283506428631 4.81242862721625e-05 MirTarget;miRNATAP -0.345528402467881 3.41810339834798e-22 NA NA NA hsa-miR-16-5p DYNC1I1 0.468459442059375 0.02635007201346 -1.12027945318246 0.00107388621207106 MirTarget;miRNATAP -0.86565440500228 1.60390565985401e-20 NA NA NA hsa-miR-16-5p DYNC1LI2 0.468459442059375 0.02635007201346 -0.151678434580852 0.11155732630237 MirTarget;miRNATAP -0.263713047268442 4.88822306654969e-26 NA NA NA hsa-miR-16-5p DYNLT3 0.468459442059375 0.02635007201346 -0.106104625502022 0.423267882184853 MirTarget -0.180671881152922 1.67965305002396e-06 NA NA NA hsa-miR-16-5p DYRK1A 0.468459442059375 0.02635007201346 -0.0929124816843609 0.267127060752188 miRNATAP -0.122202910933621 2.29966904941693e-07 NA NA NA hsa-miR-16-5p DZIP1 0.468459442059375 0.02635007201346 -0.88362320879615 0.00028568683997458 MirTarget -0.660790980105154 5.98257294559773e-24 NA NA NA hsa-miR-16-5p EDA 0.468459442059375 0.02635007201346 -0.372450144691841 0.22226981888951 MirTarget;miRNATAP -0.295533863606906 0.00080805590779757 NA NA NA hsa-miR-16-5p EGFR 0.468459442059375 0.02635007201346 -0.174568357475892 0.484508576205495 miRNAWalker2_validate -0.348371726581681 1.00705856880478e-06 NA NA NA hsa-miR-16-5p EGLN1 0.468459442059375 0.02635007201346 -0.12730652589272 0.153604768279239 MirTarget -0.15672452116794 3.20678173407267e-10 NA NA NA hsa-miR-16-5p EIF4G3 0.468459442059375 0.02635007201346 0.0244390885042307 0.814319234728122 miRNAWalker2_validate -0.172209403325218 3.74927067004461e-09 NA NA NA hsa-miR-16-5p ELL2 0.468459442059375 0.02635007201346 -1.46362215725712 1.58717825670906e-20 MirTarget;miRNATAP -0.189819970811233 0.000106803226172901 NA NA NA hsa-miR-16-5p ELOVL5 0.468459442059375 0.02635007201346 -0.0910045021719972 0.633667869483248 miRNAWalker2_validate -0.263393935043483 1.31206192206368e-06 NA NA NA hsa-miR-16-5p ENAH 0.468459442059375 0.02635007201346 -0.303508505660234 0.0898566571919018 MirTarget;miRNATAP -0.4068129300899 1.06158871426029e-16 NA NA NA hsa-miR-16-5p ENPP4 0.468459442059375 0.02635007201346 -0.190495269838545 0.28985475632262 miRNAWalker2_validate -0.159211214754704 0.00221268151389794 NA NA NA hsa-miR-16-5p ENTPD1 0.468459442059375 0.02635007201346 0.236680596078842 0.0602010987065912 MirTarget -0.276294791104924 1.42817098418098e-15 NA NA NA hsa-miR-16-5p EPC1 0.468459442059375 0.02635007201346 -0.122635046043363 0.138311155212862 miRNAWalker2_validate -0.142489118610961 7.09615053136465e-10 NA NA NA hsa-miR-16-5p EPHA7 0.468459442059375 0.02635007201346 -2.19739166323181 3.30440512414909e-05 miRNATAP -1.45381695447653 2.29128286174938e-24 NA NA NA hsa-miR-16-5p ERC2 0.468459442059375 0.02635007201346 -0.427257459724932 0.15521309382104 MirTarget;miRNATAP -0.363168714269448 2.63852580872999e-05 NA NA NA hsa-miR-16-5p EYA1 0.468459442059375 0.02635007201346 -0.459017244802486 0.202570531835921 miRNATAP -0.421699598841627 4.7315290936852e-05 NA NA NA hsa-miR-16-5p EYA4 0.468459442059375 0.02635007201346 0.300366807020702 0.36876153821282 MirTarget -0.595541590078295 2.34198952146379e-10 NA NA NA hsa-miR-16-5p EZH1 0.468459442059375 0.02635007201346 -0.563595010007821 9.54263036009044e-06 MirTarget;miRNATAP -0.350311845017341 1.41715304148468e-24 NA NA NA hsa-miR-16-5p FAM120C 0.468459442059375 0.02635007201346 0.170776103390755 0.263203241775743 MirTarget;miRNATAP -0.24251786561285 1.95152991871082e-08 NA NA NA hsa-miR-16-5p FAM122A 0.468459442059375 0.02635007201346 -0.303994263706123 0.000409216969430765 miRNAWalker2_validate -0.113906212988459 3.89179093696477e-06 NA NA NA hsa-miR-16-5p FAM131A 0.468459442059375 0.02635007201346 -0.453263150372832 0.000487625804146054 mirMAP -0.199465229509127 8.26882637881847e-08 NA NA NA hsa-miR-16-5p FAM161A 0.468459442059375 0.02635007201346 0.184954654544411 0.214390035381984 MirTarget -0.105818750490971 0.0142470624848307 NA NA NA hsa-miR-16-5p FAM168A 0.468459442059375 0.02635007201346 -0.191804273695932 0.128925621940858 miRNAWalker2_validate -0.147799332865353 4.50449465111196e-05 NA NA NA hsa-miR-16-5p FAM189A1 0.468459442059375 0.02635007201346 -2.65743696971689 6.59320514962127e-07 MirTarget;miRNATAP -0.891600882919426 8.31634010568444e-09 NA NA NA hsa-miR-16-5p FAM196A 0.468459442059375 0.02635007201346 -0.288120566953572 0.21491857896918 miRNATAP -0.250969769901979 0.000177812481450574 NA NA NA hsa-miR-16-5p FAM208A 0.468459442059375 0.02635007201346 0.222942633109318 0.0216547406408079 miRNAWalker2_validate -0.103947388095795 0.000195350840390413 NA NA NA hsa-miR-16-5p FAM69A 0.468459442059375 0.02635007201346 -0.657229328548528 2.26012627458719e-07 miRNAWalker2_validate -0.247105956380239 9.17331270466763e-12 NA NA NA hsa-miR-16-5p FAT2 0.468459442059375 0.02635007201346 -0.278356365218703 0.44877423623627 miRNAWalker2_validate -0.410048730730272 0.000106156791850331 NA NA NA hsa-miR-16-5p FAT3 0.468459442059375 0.02635007201346 -1.60082132479507 0.000514379028219012 miRNAWalker2_validate;MirTarget;miRNATAP -1.33478598476398 6.81416091906746e-28 NA NA NA hsa-miR-16-5p FAT4 0.468459442059375 0.02635007201346 -0.353979211281549 0.146937063510268 MirTarget -0.581351997893513 2.07564750112991e-18 NA NA NA hsa-miR-16-5p FBXL20 0.468459442059375 0.02635007201346 0.190290133062633 0.106207235760524 MirTarget -0.274497870766121 1.05415999241895e-17 NA NA NA hsa-miR-16-5p FBXO24 0.468459442059375 0.02635007201346 -0.193290141946342 0.228600488669418 mirMAP -0.146177454138543 0.00162051698608833 NA NA NA hsa-miR-16-5p FBXO3 0.468459442059375 0.02635007201346 -0.554476776198341 4.67339274952818e-11 miRNAWalker2_validate -0.16931190263038 2.86186673910462e-12 NA NA NA hsa-miR-16-5p FCHSD2 0.468459442059375 0.02635007201346 0.068173820585983 0.54665746300611 miRNATAP -0.110108314092813 0.000702930033598017 NA NA NA hsa-miR-16-5p FEM1C 0.468459442059375 0.02635007201346 -0.395479886134297 0.00021224243420561 miRNAWalker2_validate -0.171429155344935 1.83328892600423e-08 NA NA NA hsa-miR-16-5p FERMT2 0.468459442059375 0.02635007201346 -0.896574191403877 0.000646206347161597 MirTarget;miRNATAP -0.811463307004377 1.02426341546694e-32 NA NA NA hsa-miR-16-5p FGF18 0.468459442059375 0.02635007201346 0.577376156575134 0.0408104462212036 miRNATAP -0.369359265698103 5.20931508210512e-06 NA NA NA hsa-miR-16-5p FGF2 0.468459442059375 0.02635007201346 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.677411929110591 1.74059869270375e-25 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGF7 0.468459442059375 0.02635007201346 -0.41434019544902 0.185809734564159 miRNATAP -0.821178064931021 1.07301219125421e-22 NA NA NA hsa-miR-16-5p FGF9 0.468459442059375 0.02635007201346 -0.567473807130705 0.17094770957627 miRNATAP -0.292368075720853 0.0152643987915688 NA NA NA hsa-miR-16-5p FGFR1 0.468459442059375 0.02635007201346 -0.509147194592856 0.0395673749466621 miRTarBase;miRNATAP -0.537128465186198 3.99987589014271e-15 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FLCN 0.468459442059375 0.02635007201346 -0.0287679480447434 0.734531988226442 miRNAWalker2_validate -0.102337224911697 2.19398388456621e-05 NA NA NA hsa-miR-16-5p FLNA 0.468459442059375 0.02635007201346 -0.771411398655463 0.0137692934141899 miRNAWalker2_validate -0.940053137809319 7.11178406588357e-31 NA NA NA hsa-miR-16-5p FLYWCH1 0.468459442059375 0.02635007201346 -0.129620772197759 0.188303972310229 mirMAP -0.104896656816343 0.00020277709282911 NA NA NA hsa-miR-16-5p FNBP1 0.468459442059375 0.02635007201346 -0.968853731521844 4.0379880862342e-05 miRNAWalker2_validate -0.564713851318506 4.75113962777329e-18 NA NA NA hsa-miR-16-5p FRMPD1 0.468459442059375 0.02635007201346 -0.602569560944977 0.187845328261471 MirTarget -0.682042347173141 1.67729737641204e-07 NA NA NA hsa-miR-16-5p FRY 0.468459442059375 0.02635007201346 -0.418462380954893 0.0343686444672025 miRNATAP -0.367240341211716 3.86559377249958e-11 NA NA NA hsa-miR-16-5p FZD10 0.468459442059375 0.02635007201346 -0.909941827017163 0.00782584288797018 miRNATAP -0.26974499680618 0.00688587270078794 NA NA NA hsa-miR-16-5p FZD4 0.468459442059375 0.02635007201346 -0.113370323882084 0.480936634316706 MirTarget -0.306428305545196 8.38754425500858e-12 NA NA NA hsa-miR-16-5p GABARAPL1 0.468459442059375 0.02635007201346 -1.20328483426322 2.1183796887727e-11 miRNAWalker2_validate -0.364205125065008 2.86219712382393e-12 NA NA NA hsa-miR-16-5p GABPA 0.468459442059375 0.02635007201346 0.0209115160002433 0.798811912937794 MirTarget -0.124010730502971 7.58320694370613e-08 NA NA NA hsa-miR-16-5p GALNT13 0.468459442059375 0.02635007201346 -0.857168264038236 0.0743939574762176 MirTarget -0.854569455892958 2.84686773439218e-10 NA NA NA hsa-miR-16-5p GFRA2 0.468459442059375 0.02635007201346 -2.58628382037502 1.9202934668223e-14 mirMAP -0.576949052337594 1.09107875266474e-08 NA NA NA hsa-miR-16-5p GHR 0.468459442059375 0.02635007201346 -2.14662589752822 3.10775498765719e-12 MirTarget;miRNATAP -0.858253112380564 1.28699187367759e-23 NA NA NA hsa-miR-16-5p GNAL 0.468459442059375 0.02635007201346 -1.05101187353865 0.000317291051700254 miRNAWalker2_validate;miRNATAP -0.913328020507044 1.02491536087331e-33 NA NA NA hsa-miR-16-5p GNAO1 0.468459442059375 0.02635007201346 -1.85268367495665 6.00392357820662e-06 mirMAP -1.05023811939365 8.71718108847965e-21 NA NA NA hsa-miR-16-5p GOLGA1 0.468459442059375 0.02635007201346 -0.0838742308619249 0.297785765177034 MirTarget;miRNATAP -0.118271298999307 1.87826386625809e-07 NA NA NA hsa-miR-16-5p GOLGA4 0.468459442059375 0.02635007201346 0.0668555129502852 0.601837372774509 MirTarget -0.16810381915907 4.16865098974254e-06 NA NA NA hsa-miR-16-5p GPAM 0.468459442059375 0.02635007201346 0.141794492741679 0.297316336494304 miRNAWalker2_validate -0.126558939509404 0.00125314178393584 NA NA NA hsa-miR-16-5p GPR153 0.468459442059375 0.02635007201346 -0.139533614460711 0.514523373271394 miRNATAP -0.273465741279549 8.070676448918e-06 NA NA NA hsa-miR-16-5p GRAMD3 0.468459442059375 0.02635007201346 -0.455456030185696 7.57079931704227e-05 MirTarget -0.146297622845473 1.12302059328019e-05 NA NA NA hsa-miR-16-5p H6PD 0.468459442059375 0.02635007201346 0.259516322986162 0.0394780541413495 mirMAP -0.162282785330627 6.88578333649196e-06 NA NA NA hsa-miR-16-5p HACE1 0.468459442059375 0.02635007201346 -0.0722952660501157 0.552389112912003 miRNAWalker2_validate -0.19519675084236 1.26965083152588e-08 NA NA NA hsa-miR-16-5p HECTD1 0.468459442059375 0.02635007201346 -0.106152421737443 0.264016507204639 miRNATAP -0.101369325132804 0.00019421821682059 NA NA NA hsa-miR-16-5p HELZ 0.468459442059375 0.02635007201346 0.176175036710462 0.0467006752430842 miRNAWalker2_validate;MirTarget;miRNATAP -0.103427876495712 4.414224355286e-05 NA NA NA hsa-miR-16-5p HHIPL1 0.468459442059375 0.02635007201346 0.317595615335507 0.136289877773182 mirMAP -0.295691278374031 1.20701357065279e-06 NA NA NA hsa-miR-16-5p HOXA3 0.468459442059375 0.02635007201346 0.0728298006718813 0.749239655839302 miRNAWalker2_validate;miRNATAP -0.563711414661623 4.64569841926458e-20 NA NA NA hsa-miR-16-5p HOXD1 0.468459442059375 0.02635007201346 -0.029373036593328 0.908678367896258 miRNATAP -0.183897957410029 0.0132692867407015 NA NA NA hsa-miR-16-5p HPCAL4 0.468459442059375 0.02635007201346 -3.30571688739834 1.29667683864775e-16 MirTarget -0.600553907426036 7.53484613838197e-07 NA NA NA hsa-miR-16-5p HPSE2 0.468459442059375 0.02635007201346 -3.51513084789656 1.06693416509876e-13 MirTarget -0.906966667668261 8.40633462064113e-11 NA NA NA hsa-miR-16-5p HSPA1A 0.468459442059375 0.02635007201346 -0.370346353218471 0.148021401695504 miRNAWalker2_validate -0.295135639859959 6.20674865181698e-05 NA NA NA hsa-miR-16-5p HSPA4L 0.468459442059375 0.02635007201346 -0.099897034975418 0.743997596825237 miRNAWalker2_validate;MirTarget -0.175422607049639 0.0485539860436279 NA NA NA hsa-miR-16-5p HSPG2 0.468459442059375 0.02635007201346 0.661442901032608 0.000453126923030142 MirTarget -0.315616033212308 4.54652310353776e-09 NA NA NA hsa-miR-16-5p HTR2A 0.468459442059375 0.02635007201346 -0.0710788448464774 0.841841357342253 MirTarget -0.74907282785162 2.82906380788781e-14 NA NA NA hsa-miR-16-5p HTRA1 0.468459442059375 0.02635007201346 0.213481585828939 0.258670710418387 miRNAWalker2_validate -0.260626346480076 1.35303091389739e-06 NA NA NA hsa-miR-16-5p IDS 0.468459442059375 0.02635007201346 -0.0995092469681822 0.452237040895841 miRNAWalker2_validate -0.313657379074617 2.27395060482473e-18 NA NA NA hsa-miR-16-5p IFT74 0.468459442059375 0.02635007201346 -0.242728882522678 0.0897650185438442 miRNAWalker2_validate;MirTarget -0.152826339983316 0.000207885325306881 NA NA NA hsa-miR-16-5p IGF1R 0.468459442059375 0.02635007201346 0.116961071763603 0.57112438908184 miRNATAP -0.294886587581129 5.30338289297577e-07 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-16-5p IGSF1 0.468459442059375 0.02635007201346 -1.56519148367387 0.00072224183946043 miRNAWalker2_validate -0.671683974078191 4.73865862847679e-07 NA NA NA hsa-miR-16-5p IGSF9B 0.468459442059375 0.02635007201346 0.239398049711897 0.455821977868752 mirMAP -0.600778460398257 2.30942826429707e-11 NA NA NA hsa-miR-16-5p IKZF4 0.468459442059375 0.02635007201346 0.120876190425539 0.27264974134199 miRNAWalker2_validate -0.212180792922015 4.16292033197111e-12 NA NA NA hsa-miR-16-5p ILDR2 0.468459442059375 0.02635007201346 1.16237294137083 0.00026098079531004 MirTarget -0.500413354598693 4.44438330790511e-08 NA NA NA hsa-miR-16-5p INSR 0.468459442059375 0.02635007201346 0.318597619732127 0.00888759738704957 miRNATAP -0.132412543732975 0.000164501860539401 NA NA NA hsa-miR-16-5p IPO7 0.468459442059375 0.02635007201346 0.357155727271068 0.00106813004083192 miRNAWalker2_validate;MirTarget;miRNATAP -0.174464901967249 1.96133801631592e-08 NA NA NA hsa-miR-16-5p IRF2BPL 0.468459442059375 0.02635007201346 -0.347058176218165 0.0033304436134852 MirTarget;miRNATAP -0.199035713214705 2.81439486748525e-09 NA NA NA hsa-miR-16-5p IRS4 0.468459442059375 0.02635007201346 -2.36249743886607 2.07501297504123e-05 miRNAWalker2_validate -0.506285078891545 0.00193440388122074 NA NA NA hsa-miR-16-5p ISLR 0.468459442059375 0.02635007201346 0.5321687918509 0.0784934792224033 MirTarget;miRNATAP -0.580106747262188 7.41558860079758e-12 NA NA NA hsa-miR-16-5p ITGA10 0.468459442059375 0.02635007201346 -0.246637441238828 0.206017591376249 MirTarget -0.415722898275786 1.15496956633378e-14 NA NA NA hsa-miR-16-5p ITPR1 0.468459442059375 0.02635007201346 -0.978205239289609 1.76770291502282e-06 MirTarget;miRNATAP -0.426035149856977 1.98295555494393e-13 NA NA NA hsa-miR-16-5p JUN 0.468459442059375 0.02635007201346 -0.932062991848233 5.08561574713346e-09 miRNAWalker2_validate -0.25231147076691 6.33617418839725e-08 NA NA NA hsa-miR-16-5p KALRN 0.468459442059375 0.02635007201346 -0.81945095030466 1.13835675548545e-05 miRNATAP -0.232250653621005 1.99983909509575e-05 NA NA NA hsa-miR-16-5p KATNAL1 0.468459442059375 0.02635007201346 -0.238121876187191 0.227473164378047 miRNAWalker2_validate;MirTarget -0.576834242990971 2.45434054300305e-29 NA NA NA hsa-miR-16-5p KCNA6 0.468459442059375 0.02635007201346 -1.53132401304961 0.000130733110947696 MirTarget -0.71607705352043 3.55441918962027e-10 NA NA NA hsa-miR-16-5p KCNAB1 0.468459442059375 0.02635007201346 -0.754968741669846 1.71183749506925e-05 MirTarget;miRNATAP -0.40771787344237 6.31043670758783e-17 NA NA NA hsa-miR-16-5p KCND3 0.468459442059375 0.02635007201346 -1.25081349685282 8.58949377013892e-05 miRNAWalker2_validate -0.520563234771297 1.25600605292301e-08 NA NA NA hsa-miR-16-5p KCNG3 0.468459442059375 0.02635007201346 1.34395433211512 0.00292915672273903 miRNAWalker2_validate -0.485467764365733 0.000216668342201846 NA NA NA hsa-miR-16-5p KCNIP1 0.468459442059375 0.02635007201346 -0.519411010060551 0.200003568379995 MirTarget -0.779934711865576 5.90355764461817e-12 NA NA NA hsa-miR-16-5p KCNJ5 0.468459442059375 0.02635007201346 -0.280638251899976 0.333902387273937 mirMAP -0.223988166396357 0.00783950693720133 NA NA NA hsa-miR-16-5p KCNK3 0.468459442059375 0.02635007201346 -2.64642442933474 6.10994924328681e-09 mirMAP -1.10324495193175 6.67859561321954e-18 NA NA NA hsa-miR-16-5p KCNQ5 0.468459442059375 0.02635007201346 -2.00119079597222 6.28495431412454e-08 miRNATAP -0.679646886581465 1.97103627716931e-10 NA NA NA hsa-miR-16-5p KCNS2 0.468459442059375 0.02635007201346 -1.13465059933003 0.00300428795437821 miRNAWalker2_validate -0.266840931865886 0.0171216284325409 NA NA NA hsa-miR-16-5p KCTD8 0.468459442059375 0.02635007201346 -3.35886720251249 5.7801142054181e-10 miRNATAP -1.20221835702838 8.97490683184298e-15 NA NA NA hsa-miR-16-5p KDSR 0.468459442059375 0.02635007201346 0.239472778487095 0.0221636390920047 miRNAWalker2_validate;miRNATAP -0.152450046499612 3.05033832050861e-07 NA NA NA hsa-miR-16-5p KIAA0513 0.468459442059375 0.02635007201346 -0.784927887721409 7.70902360744078e-06 mirMAP -0.25023357301926 8.90429237715627e-07 NA NA NA hsa-miR-16-5p KIAA1614 0.468459442059375 0.02635007201346 -0.672817277076573 0.000878485556645909 mirMAP -0.506873064957155 3.45265899634808e-20 NA NA NA hsa-miR-16-5p KIAA1644 0.468459442059375 0.02635007201346 -1.36705906491291 0.000314678328832303 mirMAP -0.982679788998926 1.49526021456793e-21 NA NA NA hsa-miR-16-5p KIAA2022 0.468459442059375 0.02635007201346 -2.80598433621504 1.14813298037395e-09 MirTarget;miRNATAP -1.21400755920785 2.80818507031927e-21 NA NA NA hsa-miR-16-5p KIDINS220 0.468459442059375 0.02635007201346 -0.00131844135927928 0.988667768580193 miRNAWalker2_validate -0.217711391772549 3.67213196440608e-18 NA NA NA hsa-miR-16-5p KIF1B 0.468459442059375 0.02635007201346 -0.118034064564058 0.322584301029128 miRNAWalker2_validate;miRNATAP -0.243990933623704 1.3488633205512e-13 NA NA NA hsa-miR-16-5p KIF5A 0.468459442059375 0.02635007201346 -1.17412567940313 0.000901231572332803 miRNAWalker2_validate;MirTarget;miRNATAP -0.865700848787583 3.89765198818372e-19 NA NA NA hsa-miR-16-5p KIF5B 0.468459442059375 0.02635007201346 0.362139773365226 0.000658119616719543 miRNAWalker2_validate;miRNATAP -0.157872177721069 2.07586195887078e-07 NA NA NA hsa-miR-16-5p KIF5C 0.468459442059375 0.02635007201346 -0.770271099699533 0.00199021863152459 MirTarget;miRNATAP -0.33928946276061 2.28955568054353e-06 NA NA NA hsa-miR-16-5p KIRREL 0.468459442059375 0.02635007201346 0.573166115265245 0.00487177562588392 mirMAP -0.340796117799119 3.88069691869717e-09 NA NA NA hsa-miR-16-5p KLHDC8B 0.468459442059375 0.02635007201346 -0.829214497649129 1.56042718520463e-06 MirTarget -0.343981642976743 2.40576774744741e-12 NA NA NA hsa-miR-16-5p KLHL15 0.468459442059375 0.02635007201346 -0.362737945993933 0.012962856301377 miRNATAP -0.271029799208333 3.8988462149202e-11 NA NA NA hsa-miR-16-5p KLHL2 0.468459442059375 0.02635007201346 -0.0642115347207799 0.550174102630369 miRNATAP -0.129591870518469 2.39015858023852e-05 NA NA NA hsa-miR-16-5p KLHL21 0.468459442059375 0.02635007201346 -0.0975845665313919 0.477450242980798 mirMAP -0.269917095190094 1.48054758756288e-12 NA NA NA hsa-miR-16-5p KPNA3 0.468459442059375 0.02635007201346 0.252104157916224 0.00901567663252874 miRNAWalker2_validate;miRNATAP -0.103984074315861 0.000182093521915884 NA NA NA hsa-miR-16-5p KPNA4 0.468459442059375 0.02635007201346 0.138060971190837 0.137094124998354 miRNATAP -0.177392168920165 5.9025359220201e-12 NA NA NA hsa-miR-16-5p KPNA6 0.468459442059375 0.02635007201346 0.116490780512301 0.10622437759634 mirMAP;miRNATAP -0.106353286318521 1.57933970238701e-07 NA NA NA hsa-miR-16-5p KY 0.468459442059375 0.02635007201346 -2.68721369383042 5.09858933207314e-11 MirTarget -0.952949552316603 3.46723406078986e-16 NA NA NA hsa-miR-16-5p L1CAM 0.468459442059375 0.02635007201346 -1.36992600914329 0.00305982026557787 miRNAWalker2_validate -0.936167139589441 5.17382745400697e-13 NA NA NA hsa-miR-16-5p LAMB1 0.468459442059375 0.02635007201346 0.781376511163481 3.99206690301919e-08 miRNAWalker2_validate -0.153100626455691 0.000273029400359765 NA NA NA hsa-miR-16-5p LAMC1 0.468459442059375 0.02635007201346 0.370285667657678 0.0366283240859651 miRNAWalker2_validate;MirTarget -0.34568030515619 2.92954987151097e-12 NA NA NA hsa-miR-16-5p LATS1 0.468459442059375 0.02635007201346 0.108677825624674 0.342084497365957 miRNAWalker2_validate;MirTarget;miRNATAP -0.155149099877995 1.86199531577411e-06 NA NA NA hsa-miR-16-5p LATS2 0.468459442059375 0.02635007201346 0.159417049044428 0.23040279833664 miRNATAP -0.323008139810548 2.35421366209395e-19 NA NA NA hsa-miR-16-5p LDLRAD2 0.468459442059375 0.02635007201346 0.569786824502446 0.000691379024921154 MirTarget -0.238511013428141 7.97697097767497e-07 NA NA NA hsa-miR-16-5p LDOC1L 0.468459442059375 0.02635007201346 -0.0790407162093647 0.481748910951884 mirMAP -0.113270919050502 0.000445566803306658 NA NA NA hsa-miR-16-5p LIG4 0.468459442059375 0.02635007201346 -0.0223675428716588 0.846578792718768 miRNAWalker2_validate -0.119230287270605 0.000324599503081908 NA NA NA hsa-miR-16-5p LIN7C 0.468459442059375 0.02635007201346 0.24175305422481 0.0265810890372601 miRNAWalker2_validate -0.139441530297821 7.81433863146203e-06 NA NA NA hsa-miR-16-5p LMX1B 0.468459442059375 0.02635007201346 0.29797438250427 0.580935368573424 mirMAP -0.319177184183924 0.0420641365000263 NA NA NA hsa-miR-16-5p LONRF2 0.468459442059375 0.02635007201346 -2.03899615797417 9.63293546267136e-06 miRNAWalker2_validate;mirMAP -1.12374527770003 1.17310427361064e-18 NA NA NA hsa-miR-16-5p LPP 0.468459442059375 0.02635007201346 -0.458891651324375 0.0447471835132921 mirMAP;miRNATAP -0.796205529944824 3.81239052718375e-46 NA NA NA hsa-miR-16-5p LRIG1 0.468459442059375 0.02635007201346 -0.5374742879248 0.00587721628379153 MirTarget -0.375383643444201 7.45754189277738e-12 NA NA NA hsa-miR-16-5p LRIG2 0.468459442059375 0.02635007201346 0.233646121703766 0.020894431221445 MirTarget -0.125173660911016 1.54624163044483e-05 NA NA NA hsa-miR-16-5p LRP1B 0.468459442059375 0.02635007201346 -2.16345659630435 6.96966627503369e-08 MirTarget;miRNATAP -0.928916768239105 2.02133930764754e-16 NA NA NA hsa-miR-16-5p LRP6 0.468459442059375 0.02635007201346 0.526407698113248 1.3788363910036e-05 miRNATAP -0.110493252843006 0.00185180406854409 NA NA NA hsa-miR-16-5p LRRC58 0.468459442059375 0.02635007201346 0.66871614549604 1.31610828919559e-10 miRNATAP -0.119278606802942 0.000116264518628475 NA NA NA hsa-miR-16-5p LRRC7 0.468459442059375 0.02635007201346 -1.34133723141535 0.0119253573751723 MirTarget -1.36620338715309 2.63867324517941e-21 NA NA NA hsa-miR-16-5p LRRC8C 0.468459442059375 0.02635007201346 0.211614278241733 0.126207579285338 MirTarget -0.112548199391242 0.00494434337829752 NA NA NA hsa-miR-16-5p LRRN3 0.468459442059375 0.02635007201346 -0.39264287572501 0.162925453177655 MirTarget;miRNATAP -0.449253733110381 1.82456508380679e-08 NA NA NA hsa-miR-16-5p LSM11 0.468459442059375 0.02635007201346 0.273916573216644 0.0292937409084412 MirTarget -0.22903720839219 8.37969991727e-11 NA NA NA hsa-miR-16-5p LURAP1L 0.468459442059375 0.02635007201346 0.456363320793577 0.0193737261905497 MirTarget -0.195186730887635 0.000555462549798469 NA NA NA hsa-miR-16-5p LUZP1 0.468459442059375 0.02635007201346 0.0204348350345764 0.850767351504186 miRNAWalker2_validate;MirTarget;miRNATAP -0.1007771537632 0.00124380121286443 NA NA NA hsa-miR-16-5p LYPLAL1 0.468459442059375 0.02635007201346 -0.157177158574202 0.196866811618413 MirTarget -0.124297200442016 0.000387251260067252 NA NA NA hsa-miR-16-5p MACF1 0.468459442059375 0.02635007201346 0.0187245853067326 0.903346275968091 miRNAWalker2_validate -0.382566258295924 2.93572233474812e-20 NA NA NA hsa-miR-16-5p MAFG 0.468459442059375 0.02635007201346 0.222547086064494 0.028030617181556 mirMAP -0.126200824556993 1.33620512633729e-05 NA NA NA hsa-miR-16-5p MAMSTR 0.468459442059375 0.02635007201346 -0.262072467781216 0.163325180352557 MirTarget;miRNATAP -0.246278319678877 4.72047360206753e-06 NA NA NA hsa-miR-16-5p MAP3K3 0.468459442059375 0.02635007201346 -0.290635931768054 0.0156524405164107 MirTarget;miRNATAP -0.243028170347395 3.64755013326269e-13 NA NA NA hsa-miR-16-5p MAP4 0.468459442059375 0.02635007201346 -0.163588092539192 0.111437492900646 miRNAWalker2_validate -0.209564074200104 1.57041941365428e-13 NA NA NA hsa-miR-16-5p MASP1 0.468459442059375 0.02635007201346 -2.34760889536794 1.59773340164496e-10 MirTarget -0.606164314674776 2.01602511796994e-08 NA NA NA hsa-miR-16-5p MBNL2 0.468459442059375 0.02635007201346 -0.199715343562235 0.128021493866242 MirTarget -0.290990291333595 6.06618708169959e-16 NA NA NA hsa-miR-16-5p MDM4 0.468459442059375 0.02635007201346 0.345358152785799 0.00761701135215303 mirMAP -0.197164040350921 8.9490623845823e-08 NA NA NA hsa-miR-16-5p MEGF8 0.468459442059375 0.02635007201346 -0.00501465406510615 0.971290876783669 miRNAWalker2_validate -0.141768874070479 0.00040144463024231 NA NA NA hsa-miR-16-5p MEOX2 0.468459442059375 0.02635007201346 -0.305974715077866 0.450206805337241 MirTarget -0.905672280661752 3.91280095435918e-16 NA NA NA hsa-miR-16-5p MERTK 0.468459442059375 0.02635007201346 -0.375050627963859 0.0156091204089872 miRNAWalker2_validate -0.151421449728791 0.000749619054388403 NA NA NA hsa-miR-16-5p MEX3B 0.468459442059375 0.02635007201346 0.725871921297744 2.11635015696509e-05 mirMAP -0.181532359617913 0.000278683844453647 NA NA NA hsa-miR-16-5p MFAP5 0.468459442059375 0.02635007201346 -1.38773655702249 0.000288777288845266 MirTarget -0.718974596134424 3.50862886378419e-11 NA NA NA hsa-miR-16-5p MFN2 0.468459442059375 0.02635007201346 -0.647864677799688 2.8742769870846e-10 miRNAWalker2_validate;MirTarget -0.115472419116993 0.000154835644431568 NA NA NA hsa-miR-16-5p MIB1 0.468459442059375 0.02635007201346 0.377930072259812 0.0014356013263503 miRNAWalker2_validate;miRNATAP -0.172105762637889 3.97832502389678e-07 NA NA NA hsa-miR-16-5p MICALL1 0.468459442059375 0.02635007201346 -1.07593882194617 4.8125987786878e-15 mirMAP -0.179390964165711 1.59936941240217e-05 NA NA NA hsa-miR-16-5p MINA 0.468459442059375 0.02635007201346 -0.0188006790392334 0.853825914775513 miRNAWalker2_validate -0.15521536489991 7.01057242507052e-08 NA NA NA hsa-miR-16-5p MIPOL1 0.468459442059375 0.02635007201346 -0.447829692526657 0.0518176143675605 MirTarget -0.306088001248239 3.56916648755153e-06 NA NA NA hsa-miR-16-5p MKL2 0.468459442059375 0.02635007201346 -0.0606062035513188 0.556642646863117 mirMAP -0.214991688547239 3.33117801274413e-14 NA NA NA hsa-miR-16-5p MKX 0.468459442059375 0.02635007201346 -0.435370995520897 0.251965832901685 MirTarget -1.02933078632379 1.95893870636024e-24 NA NA NA hsa-miR-16-5p MLLT11 0.468459442059375 0.02635007201346 -0.661499646297612 0.0173342419671774 miRNAWalker2_validate -0.55520039929566 9.13651104251797e-13 NA NA NA hsa-miR-16-5p MLXIP 0.468459442059375 0.02635007201346 0.160252052914747 0.247608838546493 mirMAP -0.159345384262891 6.1403879251598e-05 NA NA NA hsa-miR-16-5p MLYCD 0.468459442059375 0.02635007201346 -0.854008710760923 8.99149875365599e-11 MirTarget -0.125637518375925 0.00145627140057683 NA NA NA hsa-miR-16-5p MMD 0.468459442059375 0.02635007201346 0.358596402380194 0.0168656186141133 miRNATAP -0.230934052855818 6.46319342433511e-08 NA NA NA hsa-miR-16-5p MORF4L1 0.468459442059375 0.02635007201346 -0.050308393481524 0.532285102555087 miRNAWalker2_validate -0.10283256902362 6.64486930396549e-06 NA NA NA hsa-miR-16-5p MRAS 0.468459442059375 0.02635007201346 -0.140957991947981 0.473453737783408 miRNATAP -0.42374282985915 5.06025593284345e-15 NA NA NA hsa-miR-16-5p MRC2 0.468459442059375 0.02635007201346 0.317111233799408 0.110374875803994 miRNAWalker2_validate -0.303052042136849 8.05753098368036e-08 NA NA NA hsa-miR-16-5p MTSS1 0.468459442059375 0.02635007201346 -0.810088738785264 0.000353714566592768 miRNATAP -0.242236950988633 0.000246336533270653 NA NA NA hsa-miR-16-5p MTSS1L 0.468459442059375 0.02635007201346 -0.0650296407852853 0.747126264282662 mirMAP -0.380370991245977 1.45342651275262e-11 NA NA NA hsa-miR-16-5p MYBL1 0.468459442059375 0.02635007201346 0.493754443604026 0.0215216223713438 miRNATAP -0.181248792407577 0.00369626426542388 NA NA NA hsa-miR-16-5p MYLK 0.468459442059375 0.02635007201346 -1.44806395967964 9.65012105905573e-05 MirTarget;miRNATAP -1.21827756361636 6.93194595929753e-38 NA NA NA hsa-miR-16-5p MYLK4 0.468459442059375 0.02635007201346 0.333416398515097 0.102749467602 MirTarget -0.233793510175809 7.06274802590695e-05 NA NA NA hsa-miR-16-5p MYO5A 0.468459442059375 0.02635007201346 -0.085562862894208 0.616615957919168 miRNAWalker2_validate;MirTarget -0.247950594795684 3.33122759118499e-07 NA NA NA hsa-miR-16-5p MYRIP 0.468459442059375 0.02635007201346 -2.5374866261714 8.43578141822633e-10 MirTarget -0.627292847610147 2.67882599295866e-07 NA NA NA hsa-miR-16-5p NAPG 0.468459442059375 0.02635007201346 -0.0344836750791524 0.746418121504312 miRNAWalker2_validate;MirTarget -0.127532147241261 2.78577248792383e-05 NA NA NA hsa-miR-16-5p NAV1 0.468459442059375 0.02635007201346 0.477474295721475 0.00162695645144269 MirTarget;miRNATAP -0.188279364690914 1.68217487893345e-05 NA NA NA hsa-miR-16-5p NAV2 0.468459442059375 0.02635007201346 -0.121843329970551 0.549053973627072 miRNAWalker2_validate -0.454131857946469 3.70288888680419e-16 NA NA NA hsa-miR-16-5p NCKAP5L 0.468459442059375 0.02635007201346 0.322011859255949 0.0204832533388973 miRNAWalker2_validate -0.146761907406723 0.000254004434309034 NA NA NA hsa-miR-16-5p NCS1 0.468459442059375 0.02635007201346 -0.652620477793938 0.0278454371426777 MirTarget;miRNATAP -0.762044031720421 1.56522891097031e-21 NA NA NA hsa-miR-16-5p NDST1 0.468459442059375 0.02635007201346 -0.130588786602125 0.314387734671676 mirMAP -0.14455568247107 0.000103793774758651 NA NA NA hsa-miR-16-5p NEMF 0.468459442059375 0.02635007201346 0.150035974961459 0.138103016801428 miRNAWalker2_validate -0.15507528536975 5.84847005853047e-08 NA NA NA hsa-miR-16-5p NFASC 0.468459442059375 0.02635007201346 -1.21285969875073 0.000588897114251105 MirTarget;mirMAP -0.923025171149299 4.38768037522679e-22 21081469 NF κB targets miR 16 and miR 21 in gastric cancer: involvement of prostaglandin E receptors gastric cancer hsa-miR-16-5p NFAT5 0.468459442059375 0.02635007201346 0.461239695424155 0.000656069696676909 MirTarget -0.271054050062119 9.17697579506393e-13 NA NA NA hsa-miR-16-5p NIN 0.468459442059375 0.02635007201346 -0.252681320029704 0.137941934206193 miRNAWalker2_validate -0.27170905073939 1.791341734522e-08 NA NA NA hsa-miR-16-5p NISCH 0.468459442059375 0.02635007201346 -0.213906871340342 0.0375209797915912 miRNAWalker2_validate;MirTarget -0.195189424772162 9.94895953589447e-12 NA NA NA hsa-miR-16-5p NLGN1 0.468459442059375 0.02635007201346 -2.68234371159062 4.2506090500709e-08 miRNATAP -1.18542248163708 5.26967902480931e-18 NA NA NA hsa-miR-16-5p NOS1 0.468459442059375 0.02635007201346 -2.96330117656761 1.10501685397827e-08 miRNATAP -1.53566922759355 4.31480263010233e-28 NA NA NA hsa-miR-16-5p NOTCH2 0.468459442059375 0.02635007201346 0.138226358603258 0.351625722215957 miRNAWalker2_validate;MirTarget -0.25803041862607 6.08848169007449e-10 NA NA NA hsa-miR-16-5p NPR3 0.468459442059375 0.02635007201346 -1.50737055199652 6.49105069424171e-05 miRNAWalker2_validate -0.877956746326212 5.13448450596525e-17 NA NA NA hsa-miR-16-5p NR2C2 0.468459442059375 0.02635007201346 0.210165761701234 0.0322359853207322 MirTarget -0.184161521301135 1.74423201243664e-11 NA NA NA hsa-miR-16-5p NRP1 0.468459442059375 0.02635007201346 0.575916847809068 0.000209823999859742 miRNAWalker2_validate -0.16839528476308 0.000196487305770999 NA NA NA hsa-miR-16-5p NRXN1 0.468459442059375 0.02635007201346 -3.77804960296992 8.78046893071678e-12 miRNAWalker2_validate -1.39938009409184 4.29240071489581e-19 NA NA NA hsa-miR-16-5p NTN1 0.468459442059375 0.02635007201346 -2.06447596754744 1.49348953834274e-09 mirMAP -0.949150266274954 4.79582430826333e-24 NA NA NA hsa-miR-16-5p NUAK1 0.468459442059375 0.02635007201346 0.903691548095403 1.06789665825318e-08 MirTarget -0.201242797582886 1.57782975535527e-05 NA NA NA hsa-miR-16-5p NUCKS1 0.468459442059375 0.02635007201346 0.325102076142334 0.00397222584600734 MirTarget;miRNATAP -0.147282996492871 5.44529489687387e-06 NA NA NA hsa-miR-16-5p NYNRIN 0.468459442059375 0.02635007201346 -0.630390629178288 0.00200658592231293 miRNATAP -0.303599530476524 2.12103059526743e-07 NA NA NA hsa-miR-16-5p OCRL 0.468459442059375 0.02635007201346 -0.0947309485303247 0.387392454978538 miRNATAP -0.212830381149064 2.55921665658822e-12 NA NA NA hsa-miR-16-5p OTUD3 0.468459442059375 0.02635007201346 0.435976725971797 0.00592113449804049 mirMAP -0.168170989559226 0.000246053161002335 NA NA NA hsa-miR-16-5p OTUD7B 0.468459442059375 0.02635007201346 0.125414398965607 0.159181493421655 miRNAWalker2_validate -0.142037675788495 1.43652449616841e-08 NA NA NA hsa-miR-16-5p PACSIN3 0.468459442059375 0.02635007201346 -0.27334408792554 0.250309873234724 miRNAWalker2_validate -0.263485512762788 0.000118738990845657 NA NA NA hsa-miR-16-5p PAFAH1B1 0.468459442059375 0.02635007201346 -0.429125161604443 1.79547396100101e-08 MirTarget;miRNATAP -0.133570353456231 1.02116440363659e-09 NA NA NA hsa-miR-16-5p PAM 0.468459442059375 0.02635007201346 -0.213715233670169 0.151419217579645 miRNATAP -0.396050410355992 1.58632350083163e-23 NA NA NA hsa-miR-16-5p PAPOLG 0.468459442059375 0.02635007201346 0.193729750745415 0.0111585726387438 miRNAWalker2_validate -0.111937839851531 2.18839531000593e-07 NA NA NA hsa-miR-16-5p PAPPA 0.468459442059375 0.02635007201346 -0.147868440566481 0.520876658558301 MirTarget;miRNATAP -0.225448753787712 0.000693353851735643 NA NA NA hsa-miR-16-5p PAQR3 0.468459442059375 0.02635007201346 -0.194298250668846 0.0935144781853434 miRNAWalker2_validate -0.184600607367071 1.7196259469888e-08 NA NA NA hsa-miR-16-5p PARVA 0.468459442059375 0.02635007201346 -0.476179816551364 0.00428675171134699 MirTarget -0.531320650956736 6.43849000894196e-36 NA NA NA hsa-miR-16-5p PBX3 0.468459442059375 0.02635007201346 -0.281102097769818 0.131536814716469 miRNATAP -0.50420802482966 2.12473951769443e-24 NA NA NA hsa-miR-16-5p PCDH17 0.468459442059375 0.02635007201346 0.730714992703952 1.70412772811198e-05 MirTarget;miRNATAP -0.194510694021036 8.89992282496763e-05 NA NA NA hsa-miR-16-5p PCDH9 0.468459442059375 0.02635007201346 -1.82279707707595 3.76874897040946e-05 MirTarget;miRNATAP -1.14209247123766 3.14895924735193e-21 NA NA NA hsa-miR-16-5p PCDHAC2 0.468459442059375 0.02635007201346 -0.527421449979268 0.137809971002795 MirTarget -0.565887087843295 2.04071091436926e-08 NA NA NA hsa-miR-16-5p PDE3B 0.468459442059375 0.02635007201346 0.366558093816732 0.0946773467248489 miRNAWalker2_validate;MirTarget -0.216845815468813 0.00062708324934599 NA NA NA hsa-miR-16-5p PDE4D 0.468459442059375 0.02635007201346 -0.501529812759653 0.00928430510499284 miRNAWalker2_validate -0.374776175816633 4.11118803599634e-12 NA NA NA hsa-miR-16-5p PDK4 0.468459442059375 0.02635007201346 -2.72064215500525 3.77755401072187e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.922764062716761 2.07153485834751e-16 NA NA NA hsa-miR-16-5p PDLIM5 0.468459442059375 0.02635007201346 -0.168385398461586 0.0796869456329142 miRNAWalker2_validate;miRNATAP -0.189232413443999 1.19299814306157e-12 NA NA NA hsa-miR-16-5p PDPR 0.468459442059375 0.02635007201346 0.163813448707733 0.242671572026521 miRNAWalker2_validate;miRNATAP -0.18777499217832 2.67867804266998e-06 NA NA NA hsa-miR-16-5p PELI2 0.468459442059375 0.02635007201346 -0.532094100359477 0.0135757742377333 miRNATAP -0.139911651025429 0.0261642985828878 NA NA NA hsa-miR-16-5p PELO 0.468459442059375 0.02635007201346 -0.183088204256144 0.0456129051147005 miRNAWalker2_validate -0.136173030617048 1.51434673450828e-07 NA NA NA hsa-miR-16-5p PHACTR2 0.468459442059375 0.02635007201346 -0.115245439006029 0.310465738797971 miRNATAP -0.222525032192817 1.66550353144373e-12 NA NA NA hsa-miR-16-5p PHC3 0.468459442059375 0.02635007201346 0.211887804282655 0.0498991979774048 miRNAWalker2_validate;MirTarget -0.195374952824763 1.08054352354553e-10 NA NA NA hsa-miR-16-5p PHF21A 0.468459442059375 0.02635007201346 -0.314340471617779 0.00621059979506441 MirTarget -0.260185824054466 1.56894935698763e-16 NA NA NA hsa-miR-16-5p PHIP 0.468459442059375 0.02635007201346 0.423267798572117 0.000305386538851739 miRNAWalker2_validate -0.147281969318514 1.36639919145173e-05 NA NA NA hsa-miR-16-5p PHKA1 0.468459442059375 0.02635007201346 -0.165201319159352 0.56191637873088 miRNAWalker2_validate -0.364000033545834 8.10717049614783e-06 NA NA NA hsa-miR-16-5p PHLDB2 0.468459442059375 0.02635007201346 -0.643125760304128 0.012847520867423 miRNAWalker2_validate -0.694262113436773 9.4621483171355e-24 NA NA NA hsa-miR-16-5p PIAS2 0.468459442059375 0.02635007201346 0.0999742411474212 0.410460583701402 MirTarget -0.122595935665893 0.000444587229355797 NA NA NA hsa-miR-16-5p PID1 0.468459442059375 0.02635007201346 -1.58515404529655 7.01847972866481e-08 MirTarget;miRNATAP -0.540141941294855 1.95870706468203e-10 NA NA NA hsa-miR-16-5p PIK3R1 0.468459442059375 0.02635007201346 -0.132584613334835 0.368540743016032 MirTarget -0.331876883174364 1.84458792077216e-16 NA NA NA hsa-miR-16-5p PIKFYVE 0.468459442059375 0.02635007201346 0.176813650074187 0.0954863222067187 MirTarget -0.113730469127719 0.000187517571828208 NA NA NA hsa-miR-16-5p PIM1 0.468459442059375 0.02635007201346 -1.11369789456653 7.42912371797285e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.18406204272965 0.000324895960142121 NA NA NA hsa-miR-16-5p PIP4K2B 0.468459442059375 0.02635007201346 0.176396912458267 0.06975976166235 miRNAWalker2_validate -0.117801372763649 2.26008185016932e-05 NA NA NA hsa-miR-16-5p PITPNM2 0.468459442059375 0.02635007201346 -0.467517560436463 0.00215939954517204 mirMAP -0.261987341814328 1.37656447618743e-09 NA NA NA hsa-miR-16-5p PITPNM3 0.468459442059375 0.02635007201346 -1.63914377631659 3.3142339868577e-07 MirTarget -0.680937041324097 7.89021186643839e-14 NA NA NA hsa-miR-16-5p PLEC 0.468459442059375 0.02635007201346 0.562959901812738 0.000191283292894481 miRNAWalker2_validate -0.116765430775774 0.00827354225527411 NA NA NA hsa-miR-16-5p PLEKHA1 0.468459442059375 0.02635007201346 0.13326283541206 0.23636502532347 MirTarget;miRNATAP -0.118684575126443 0.000238751001223287 NA NA NA hsa-miR-16-5p PLEKHA5 0.468459442059375 0.02635007201346 -0.0209985094569882 0.878336125773638 MirTarget -0.293982866819479 6.28745866141324e-15 NA NA NA hsa-miR-16-5p PLEKHM3 0.468459442059375 0.02635007201346 -0.264766226099178 0.0391508799138563 MirTarget -0.377664842640504 8.87253566966314e-30 NA NA NA hsa-miR-16-5p PLSCR4 0.468459442059375 0.02635007201346 -0.474237245058613 0.0383317279289207 miRNAWalker2_validate;MirTarget -0.656407825643764 8.88816740538975e-28 NA NA NA hsa-miR-16-5p PLXDC1 0.468459442059375 0.02635007201346 0.820266014829211 1.64486390939186e-07 mirMAP -0.207754578345269 6.03089285063548e-06 NA NA NA hsa-miR-16-5p PLXNA2 0.468459442059375 0.02635007201346 -0.394952139559956 0.00778505791950615 MirTarget;miRNATAP -0.108987714429131 0.0116859243717001 NA NA NA hsa-miR-16-5p PMP2 0.468459442059375 0.02635007201346 -3.58172675758482 1.88286205374656e-12 miRNATAP -1.35899577865752 2.03979545184531e-21 NA NA NA hsa-miR-16-5p PNISR 0.468459442059375 0.02635007201346 -0.0767243216354423 0.536610143649601 MirTarget;miRNATAP -0.176743645174074 5.33818147146534e-07 NA NA NA hsa-miR-16-5p PNMAL2 0.468459442059375 0.02635007201346 -0.388731784393724 0.0887590872423807 MirTarget -0.465078278679235 2.43404850231523e-13 NA NA NA hsa-miR-16-5p PPM1A 0.468459442059375 0.02635007201346 -0.623302585337666 5.30525296218818e-12 MirTarget;miRNATAP -0.206808354230169 9.99481554301912e-16 NA NA NA hsa-miR-16-5p PPM1E 0.468459442059375 0.02635007201346 0.150874141379553 0.574319966175631 MirTarget -0.219013045585152 0.00487073573765172 NA NA NA hsa-miR-16-5p PPM1K 0.468459442059375 0.02635007201346 -0.999161564755304 1.37921237142718e-08 MirTarget -0.370799461906485 1.55912735282222e-13 NA NA NA hsa-miR-16-5p PPM1L 0.468459442059375 0.02635007201346 -0.537351176754866 0.00615520293012723 MirTarget -0.366939668357723 3.08362601116875e-11 NA NA NA hsa-miR-16-5p PPP3CB 0.468459442059375 0.02635007201346 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.238877122232723 7.04452900892349e-17 NA NA NA hsa-miR-16-5p PRKAB2 0.468459442059375 0.02635007201346 -0.367111274928678 0.0137111089812302 miRNAWalker2_validate;MirTarget -0.390410015091595 1.35560566353115e-22 NA NA NA hsa-miR-16-5p PRKAR1A 0.468459442059375 0.02635007201346 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.111196535891916 3.05520193030518e-05 NA NA NA hsa-miR-16-5p PRKAR2A 0.468459442059375 0.02635007201346 -0.0807414545032392 0.4668186025327 miRNAWalker2_validate -0.149311941864718 2.22104468677917e-06 NA NA NA hsa-miR-16-5p PRKG1 0.468459442059375 0.02635007201346 -0.561746760371328 0.0108057633457725 miRNATAP -0.723985791692614 5.73785213771841e-39 NA NA NA hsa-miR-16-5p PRNP 0.468459442059375 0.02635007201346 -0.769694673212605 6.60491278620587e-05 miRNAWalker2_validate -0.462107200752552 3.76796746513687e-18 NA NA NA hsa-miR-16-5p PRTG 0.468459442059375 0.02635007201346 -0.0504992287070438 0.858450200149841 MirTarget -0.666990125331125 4.84886015884394e-18 NA NA NA hsa-miR-16-5p PRX 0.468459442059375 0.02635007201346 -0.550672139541812 0.000773270264703616 mirMAP -0.306235900140905 3.61724734902388e-11 NA NA NA hsa-miR-16-5p PTCH1 0.468459442059375 0.02635007201346 -0.0998087706005091 0.617896719568664 miRNATAP -0.201743540787871 0.00046730003608423 NA NA NA hsa-miR-16-5p PTCHD1 0.468459442059375 0.02635007201346 -2.90717877329561 5.21593618536946e-08 mirMAP -1.59141472938909 1.02697373526982e-28 NA NA NA hsa-miR-16-5p PTGFR 0.468459442059375 0.02635007201346 -0.233414407535669 0.454209756675319 miRNATAP -0.70907436971604 1.00095637786516e-16 NA NA NA hsa-miR-16-5p PTGS1 0.468459442059375 0.02635007201346 -1.86379706848248 1.06731086101655e-15 miRNAWalker2_validate -0.373638552802657 9.56999347935986e-08 NA NA NA hsa-miR-16-5p PTGS2 0.468459442059375 0.02635007201346 0.00805602322749532 0.981456994390787 miRNAWalker2_validate;miRTarBase -0.362150730587735 0.000288682376482638 24759835;25196524 MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Artesunate induces apoptosis of bladder cancer cells by miR 16 regulation of COX 2 expression; Cyclooxygenase-2 COX-2 and miR-16 expression levels were determined with real-time PCR; ART efficiently inhibited orthotopic tumor growth in the bladder cancer rat which is accompanied with an increase of miR-16 expression and a decrease of COX-2 expression; ART significantly increased miR-16 expression and decreased the expression of COX-2 and the production of PGE2; More importantly down-regulation of miR-16 expression could reverse the effect of ART on apoptosis and COX-2 expression in bladder cells; In conclusion ART can elicit an anti-tumor effect against bladder cancer by up-regulation of miR-16 expression which resulted in the decrease of COX-2 expression and PGE2 production ; liver cancer;bladder cancer hsa-miR-16-5p PTHLH 0.468459442059375 0.02635007201346 -0.698481509843736 0.00799227292455291 MirTarget -0.481056184154002 9.75543729858034e-11 NA NA NA hsa-miR-16-5p PTPDC1 0.468459442059375 0.02635007201346 0.136577706099486 0.207848124475772 miRNAWalker2_validate -0.186191854072448 9.39643548500155e-10 NA NA NA hsa-miR-16-5p PTPN14 0.468459442059375 0.02635007201346 0.144321960759363 0.345946539624122 MirTarget -0.318435294606885 5.24079040444774e-14 NA NA NA hsa-miR-16-5p PTPRD 0.468459442059375 0.02635007201346 -1.00502953098866 0.000637604436440412 miRNATAP -0.468371483110919 2.78222032992547e-08 NA NA NA hsa-miR-16-5p PTPRT 0.468459442059375 0.02635007201346 -0.907265605799675 0.0372664951342187 miRNAWalker2_validate -0.462439084316095 0.000243715742899607 NA NA NA hsa-miR-16-5p PURA 0.468459442059375 0.02635007201346 -0.330747450626133 0.000135621233435024 miRNAWalker2_validate;miRTarBase;MirTarget -0.182960303285286 3.03154618981398e-14 NA NA NA hsa-miR-16-5p PURB 0.468459442059375 0.02635007201346 0.191156761618797 0.0680497522728757 miRNATAP -0.227879719111687 2.26202165437718e-15 NA NA NA hsa-miR-16-5p RAB11FIP2 0.468459442059375 0.02635007201346 -0.259679029578217 0.0617021736002116 MirTarget;miRNATAP -0.257355160974461 3.84904952790029e-11 NA NA NA hsa-miR-16-5p RAB12 0.468459442059375 0.02635007201346 -0.331725395446472 0.00841506962855526 miRNAWalker2_validate -0.290543508736331 3.56917629561853e-17 NA NA NA hsa-miR-16-5p RAB23 0.468459442059375 0.02635007201346 -0.096112489735301 0.66521993302631 miRNAWalker2_validate -0.6738051880175 3.41584361913502e-32 NA NA NA hsa-miR-16-5p RAB30 0.468459442059375 0.02635007201346 -1.42442211692912 3.65381677106471e-13 miRNAWalker2_validate -0.125811085579793 0.0352492091272099 NA NA NA hsa-miR-16-5p RAB6B 0.468459442059375 0.02635007201346 -1.20336252314016 2.74022582273913e-07 mirMAP -0.549188147971282 5.39750018424637e-17 NA NA NA hsa-miR-16-5p RAB9B 0.468459442059375 0.02635007201346 -1.64127232803465 2.08021776444596e-07 miRNAWalker2_validate -0.937263623967241 1.43880004216929e-28 NA NA NA hsa-miR-16-5p RABGAP1 0.468459442059375 0.02635007201346 -0.106752464617506 0.378462368364444 MirTarget -0.305147682837445 5.72916017076129e-21 NA NA NA hsa-miR-16-5p RAD50 0.468459442059375 0.02635007201346 0.108139021675818 0.233439037777841 MirTarget -0.117797117831272 4.93927267902632e-06 NA NA NA hsa-miR-16-5p RAPGEF2 0.468459442059375 0.02635007201346 -0.124525519850816 0.180177043283971 miRNATAP -0.13645236867448 2.06458361223836e-07 NA NA NA hsa-miR-16-5p RARB 0.468459442059375 0.02635007201346 -0.824546396136413 1.67331828630351e-05 miRNATAP -0.345503848493916 2.71294108243076e-10 NA NA NA hsa-miR-16-5p RASA4 0.468459442059375 0.02635007201346 -0.702098653804009 8.48703305158542e-05 mirMAP -0.309711111170432 1.26620138465406e-09 NA NA NA hsa-miR-16-5p RASL12 0.468459442059375 0.02635007201346 -0.396801549711893 0.0656479695578191 miRNATAP -0.484534861107323 2.83921320057018e-16 NA NA NA hsa-miR-16-5p RASSF2 0.468459442059375 0.02635007201346 -0.273260229164372 0.2196076417753 MirTarget -0.232698429918242 0.00028901229206917 NA NA NA hsa-miR-16-5p RASSF8 0.468459442059375 0.02635007201346 -0.121570136144733 0.655913644139023 miRNATAP -0.75489970498589 9.34479005994591e-26 NA NA NA hsa-miR-16-5p RBBP6 0.468459442059375 0.02635007201346 0.162900336526808 0.0510081318834689 MirTarget;miRNATAP -0.104002356169257 1.22080332782826e-05 NA NA NA hsa-miR-16-5p RBFOX2 0.468459442059375 0.02635007201346 -0.23382535811194 0.0474300848701291 miRNATAP -0.332966917549835 4.84940739673868e-27 NA NA NA hsa-miR-16-5p RBM6 0.468459442059375 0.02635007201346 -0.136802087204089 0.156630751376673 miRNAWalker2_validate;MirTarget;miRNATAP -0.132958890718163 1.24238432010579e-06 NA NA NA hsa-miR-16-5p RBMS1 0.468459442059375 0.02635007201346 -0.0436443770031296 0.808758050496525 miRNAWalker2_validate;miRNATAP -0.433582734141843 6.75054712984761e-19 NA NA NA hsa-miR-16-5p RBMS3 0.468459442059375 0.02635007201346 -0.518802275066789 0.0355078319259322 miRNAWalker2_validate -0.778015404025929 3.97188248912575e-35 NA NA NA hsa-miR-16-5p RBPJ 0.468459442059375 0.02635007201346 0.233248695691198 0.00585943920555178 MirTarget -0.116572881434535 1.33044904839034e-06 NA NA NA hsa-miR-16-5p RCOR3 0.468459442059375 0.02635007201346 -0.119702410705573 0.230476107003849 MirTarget;miRNATAP -0.195611844991658 1.50007450356997e-12 NA NA NA hsa-miR-16-5p RECK 0.468459442059375 0.02635007201346 -1.04347373160309 9.33987268915419e-07 miRNAWalker2_validate;miRNATAP -0.562736911936963 3.98354630375811e-22 24852767 Aberrant expression level of miR-16 could suppress cell apoptosis while promote growth by regulating RECK and SOX6 which play important roles in the pathogenesis of ESCC esophageal cancer hsa-miR-16-5p REEP1 0.468459442059375 0.02635007201346 -2.11544155777275 2.02942413315448e-07 MirTarget -1.02324321272338 1.28851507387305e-19 NA NA NA hsa-miR-16-5p RELN 0.468459442059375 0.02635007201346 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -0.791658012633644 2.95909625213297e-12 NA NA NA hsa-miR-16-5p RET 0.468459442059375 0.02635007201346 -0.832755310542644 0.0351710970965439 MirTarget;miRNATAP -0.61524719187578 4.72922626906929e-08 NA NA NA hsa-miR-16-5p RGMA 0.468459442059375 0.02635007201346 -1.78164228251851 1.98608269949397e-05 MirTarget -1.23277531556544 8.21847748889296e-29 NA NA NA hsa-miR-16-5p RGS22 0.468459442059375 0.02635007201346 -0.776438245096146 0.0273705723760213 MirTarget -0.797416216907719 1.83409542464534e-16 NA NA NA hsa-miR-16-5p RHOT1 0.468459442059375 0.02635007201346 -0.195553531910098 0.0259073751726022 miRNAWalker2_validate -0.138123769184172 2.48702453754057e-08 NA NA NA hsa-miR-16-5p RICTOR 0.468459442059375 0.02635007201346 0.387516049901938 0.00188233465370784 MirTarget;miRNATAP -0.216103536683984 9.28990873731925e-10 NA NA NA hsa-miR-16-5p RIMKLB 0.468459442059375 0.02635007201346 -0.516647470958743 0.0376812451743227 MirTarget;miRNATAP -0.557214497822668 3.88640121791828e-16 NA NA NA hsa-miR-16-5p RIMS3 0.468459442059375 0.02635007201346 -1.3046164844765 2.73366807369862e-06 miRNAWalker2_validate -0.550039719466871 3.74243897805133e-12 NA NA NA hsa-miR-16-5p RNASEL 0.468459442059375 0.02635007201346 -0.27246163032033 0.0179637269468357 miRNAWalker2_validate -0.172723568473355 1.33038747089204e-07 NA NA NA hsa-miR-16-5p RNF125 0.468459442059375 0.02635007201346 -0.207018424430671 0.265318718636139 MirTarget;miRNATAP -0.202817068362318 0.000149410769320386 NA NA NA hsa-miR-16-5p RNF144B 0.468459442059375 0.02635007201346 -0.292369081593336 0.117661251051104 miRNAWalker2_validate;miRNATAP -0.175120544002421 0.00119175492332007 NA NA NA hsa-miR-16-5p RNF165 0.468459442059375 0.02635007201346 -1.11992889821903 0.00120651282301094 MirTarget -0.841019558275905 7.00319445233965e-19 NA NA NA hsa-miR-16-5p RNF217 0.468459442059375 0.02635007201346 -1.00205335921036 2.29819486137061e-05 miRNAWalker2_validate;MirTarget -0.576352037429345 1.07776787967825e-18 NA NA NA hsa-miR-16-5p ROGDI 0.468459442059375 0.02635007201346 -1.12436032365551 2.83525909681017e-19 miRNAWalker2_validate -0.126229750634274 0.00115793714770512 NA NA NA hsa-miR-16-5p ROR1 0.468459442059375 0.02635007201346 -0.861512083100719 0.000181264380069288 miRNATAP -0.390396323575309 2.93620002334994e-09 NA NA NA hsa-miR-16-5p RORA 0.468459442059375 0.02635007201346 -0.888667376601635 4.99889595160793e-06 MirTarget;miRNATAP -0.449217163889911 1.28438042075818e-16 NA NA NA hsa-miR-16-5p RP1L1 0.468459442059375 0.02635007201346 1.27544749144584 3.42791404299589e-05 miRNAWalker2_validate -0.312292145689782 0.000540162921082012 NA NA NA hsa-miR-16-5p RPRD2 0.468459442059375 0.02635007201346 0.182394409646447 0.028243213211986 miRNAWalker2_validate;MirTarget -0.126071300473449 7.9826436344628e-08 NA NA NA hsa-miR-16-5p RPS27 0.468459442059375 0.02635007201346 -0.156748223888344 0.481779147298345 miRNAWalker2_validate -0.482045175769911 3.97452664881238e-15 NA NA NA hsa-miR-16-5p RPS6KA3 0.468459442059375 0.02635007201346 0.25562324842552 0.02419259011319 miRNAWalker2_validate;MirTarget;miRNATAP -0.116897535257014 0.00034909796510496 NA NA NA hsa-miR-16-5p RPS6KA6 0.468459442059375 0.02635007201346 -2.98891177318268 6.67782798681791e-14 MirTarget -0.942831663960455 2.77048727579972e-16 NA NA NA hsa-miR-16-5p RSBN1 0.468459442059375 0.02635007201346 -0.0117811591151229 0.891572467045118 MirTarget;miRNATAP -0.112507015615545 4.38903900500146e-06 NA NA NA hsa-miR-16-5p RSPO3 0.468459442059375 0.02635007201346 -0.413092961972705 0.273194842658858 MirTarget -0.856831072178301 1.10091617031347e-16 NA NA NA hsa-miR-16-5p RTN4 0.468459442059375 0.02635007201346 -0.411549538148011 0.000141083434427497 miRNAWalker2_validate -0.220444310928212 3.29180405695384e-13 NA NA NA hsa-miR-16-5p RUNDC3B 0.468459442059375 0.02635007201346 -1.01699292837566 1.21190372674825e-05 miRNAWalker2_validate;MirTarget -0.466270812079016 1.42648320718613e-12 NA NA NA hsa-miR-16-5p RUNX1T1 0.468459442059375 0.02635007201346 -0.344000642439472 0.237404358600589 miRNAWalker2_validate;miRNATAP -0.853448907170192 1.86625514022948e-29 NA NA NA hsa-miR-16-5p RYBP 0.468459442059375 0.02635007201346 -0.114507030284895 0.11900576425575 MirTarget -0.118095377759668 9.28085076915677e-09 NA NA NA hsa-miR-16-5p SAMD4A 0.468459442059375 0.02635007201346 -0.132799293939158 0.555317186016636 MirTarget -0.610919118699233 1.22566078386166e-24 NA NA NA hsa-miR-16-5p SARM1 0.468459442059375 0.02635007201346 -0.515539220220322 0.000237694974843706 mirMAP -0.150847028681597 0.000218351389584984 NA NA NA hsa-miR-16-5p SAV1 0.468459442059375 0.02635007201346 -0.016098543470858 0.880390578434833 miRNAWalker2_validate -0.103955503450016 0.000711268120717686 NA NA NA hsa-miR-16-5p SCN2A 0.468459442059375 0.02635007201346 0.317164447705599 0.477497388671926 MirTarget -0.499338242385822 0.000102478140329756 NA NA NA hsa-miR-16-5p SCN2B 0.468459442059375 0.02635007201346 -2.22237853128849 2.58947336008345e-06 mirMAP -1.29414691030452 6.17651511646864e-24 NA NA NA hsa-miR-16-5p SCN3A 0.468459442059375 0.02635007201346 -1.5009210460306 8.66949811687225e-07 MirTarget -0.446655763921277 5.0798896298024e-07 NA NA NA hsa-miR-16-5p SCN4B 0.468459442059375 0.02635007201346 -1.50190480797345 2.55846292929615e-07 miRNATAP -0.651032178217824 2.40672662136734e-15 NA NA NA hsa-miR-16-5p SDC3 0.468459442059375 0.02635007201346 0.0412816778750296 0.815551299654887 mirMAP -0.347170643968746 1.72505827970293e-12 NA NA NA hsa-miR-16-5p SEC14L5 0.468459442059375 0.02635007201346 -2.00691526440237 3.58158652448988e-07 mirMAP -0.297667492759 0.0110835612438782 NA NA NA hsa-miR-16-5p SEC24B 0.468459442059375 0.02635007201346 -0.192388173024879 0.0123756666560841 miRNAWalker2_validate -0.11170858106646 2.88797662266644e-07 NA NA NA hsa-miR-16-5p SEMA3A 0.468459442059375 0.02635007201346 -0.179919346499373 0.561052089127856 MirTarget -0.673879056265064 2.62219404483499e-15 NA NA NA hsa-miR-16-5p SEMA3D 0.468459442059375 0.02635007201346 -1.73377572221593 1.94522521277914e-05 MirTarget;miRNATAP -0.7015294695163 1.71667994767675e-09 NA NA NA hsa-miR-16-5p SEMA4C 0.468459442059375 0.02635007201346 0.0997965897725477 0.505275274064598 miRNAWalker2_validate -0.282142181036911 1.46787972008804e-11 NA NA NA hsa-miR-16-5p SEMA6A 0.468459442059375 0.02635007201346 -0.78947725978746 0.0133684925524848 miRNATAP -0.502549626984033 3.34823133219488e-08 NA NA NA hsa-miR-16-5p SEMA6D 0.468459442059375 0.02635007201346 -1.55565558119296 1.29394597397564e-07 miRNATAP -0.443014428681467 2.63864913968424e-07 NA NA NA hsa-miR-16-5p SENP6 0.468459442059375 0.02635007201346 0.0812810872614262 0.402002112808971 miRNAWalker2_validate -0.182872490417686 1.12055764708306e-11 NA NA NA hsa-miR-16-5p SEPT2 0.468459442059375 0.02635007201346 0.106596320652431 0.143786999211975 MirTarget;miRNATAP -0.107335841877806 1.66584924066237e-07 NA NA NA hsa-miR-16-5p SERPINE2 0.468459442059375 0.02635007201346 0.124636258296181 0.636118825227613 miRNAWalker2_validate -0.3812159467436 3.72390224976044e-07 NA NA NA hsa-miR-16-5p SESN1 0.468459442059375 0.02635007201346 -0.316273897424733 0.0791103584277436 MirTarget;miRNATAP -0.144002090355108 0.00585585033060321 NA NA NA hsa-miR-16-5p SETD3 0.468459442059375 0.02635007201346 -0.269700648406957 0.000669748960778885 MirTarget -0.11536248704199 3.23383700076263e-07 NA NA NA hsa-miR-16-5p SGCA 0.468459442059375 0.02635007201346 -2.54874692316998 3.73843198020006e-09 MirTarget -1.13804092421145 2.34574733942828e-21 NA NA NA hsa-miR-16-5p SGCD 0.468459442059375 0.02635007201346 -0.462258493991732 0.100341438431502 miRNATAP -0.886687618531461 3.2148132857842e-35 NA NA NA hsa-miR-16-5p SH3GL2 0.468459442059375 0.02635007201346 -4.46378118219411 1.17801358444675e-19 MirTarget;miRNATAP -0.649291601038403 2.01744265854715e-05 NA NA NA hsa-miR-16-5p SH3PXD2B 0.468459442059375 0.02635007201346 0.571146620240805 0.000639832838972146 mirMAP -0.335379399892852 9.25658977367829e-13 NA NA NA hsa-miR-16-5p SHE 0.468459442059375 0.02635007201346 -0.487657055801679 0.0132219991840013 mirMAP -0.393080524369104 8.88721258299005e-13 NA NA NA hsa-miR-16-5p SHROOM4 0.468459442059375 0.02635007201346 0.533433249282303 0.0033357310845142 miRNATAP -0.331517193863002 1.06346392921865e-10 NA NA NA hsa-miR-16-5p SIAH1 0.468459442059375 0.02635007201346 -0.0573266239623029 0.414147265510872 miRNATAP -0.122655937983167 2.99039931302322e-10 NA NA NA hsa-miR-16-5p SIPA1L2 0.468459442059375 0.02635007201346 -0.0621530457804553 0.741518280681569 miRNAWalker2_validate;miRNATAP -0.387629937166129 1.06091042613707e-13 NA NA NA hsa-miR-16-5p SIRT4 0.468459442059375 0.02635007201346 -0.987112069506048 3.83745090789457e-09 miRNAWalker2_validate;MirTarget -0.265363609692451 6.28479478743375e-08 NA NA NA hsa-miR-16-5p SKAP2 0.468459442059375 0.02635007201346 0.107562936565811 0.411549515152348 miRNAWalker2_validate -0.245937881910346 1.65649928500954e-11 NA NA NA hsa-miR-16-5p SKI 0.468459442059375 0.02635007201346 0.22417153228759 0.0311770228305296 MirTarget;miRNATAP -0.185743944393448 1.93936523670243e-10 NA NA NA hsa-miR-16-5p SLC20A2 0.468459442059375 0.02635007201346 -0.28088699049617 0.0323486031823865 miRNATAP -0.200028903392545 8.23947219322022e-08 NA NA NA hsa-miR-16-5p SLC24A3 0.468459442059375 0.02635007201346 -0.167053424506094 0.514545085375566 miRNATAP -0.508288892828476 1.02051379807541e-12 NA NA NA hsa-miR-16-5p SLC25A12 0.468459442059375 0.02635007201346 -0.5289350164542 0.000602375078491444 MirTarget -0.346511700086447 4.72950525993153e-16 NA NA NA hsa-miR-16-5p SLC25A26 0.468459442059375 0.02635007201346 -0.394703690472408 0.00169663064559881 mirMAP -0.270412491006002 9.02909051781102e-15 NA NA NA hsa-miR-16-5p SLC29A1 0.468459442059375 0.02635007201346 -0.382382190790867 0.0143276249757502 miRNAWalker2_validate -0.168075959970885 0.000195319256255093 NA NA NA hsa-miR-16-5p SLC30A8 0.468459442059375 0.02635007201346 -2.65731049044966 2.93491403185427e-09 MirTarget -0.923925271500076 7.01526897334643e-13 NA NA NA hsa-miR-16-5p SLC38A1 0.468459442059375 0.02635007201346 0.165523798697978 0.414141102706905 miRNAWalker2_validate -0.346267168061269 1.33376566926117e-09 NA NA NA hsa-miR-16-5p SLC38A2 0.468459442059375 0.02635007201346 -0.034759634518049 0.752300156668015 miRNAWalker2_validate -0.125594203898606 6.66734422290307e-05 NA NA NA hsa-miR-16-5p SLC39A13 0.468459442059375 0.02635007201346 0.279550795527371 0.00388087580321591 mirMAP -0.100626234558429 0.000314817924757874 NA NA NA hsa-miR-16-5p SLC6A4 0.468459442059375 0.02635007201346 -3.68262138749367 4.59780243174991e-13 MirTarget;miRNATAP -0.459009736875862 0.00299974832332632 NA NA NA hsa-miR-16-5p SLC7A2 0.468459442059375 0.02635007201346 -0.504055476896812 0.159045414836461 MirTarget;miRNATAP -0.530718109472187 1.96458066368211e-07 NA NA NA hsa-miR-16-5p SMAD5 0.468459442059375 0.02635007201346 0.185272436777386 0.0565853388312257 miRNAWalker2_validate;MirTarget;miRNATAP -0.1815409536762 2.07194190890713e-11 NA NA NA hsa-miR-16-5p SNRK 0.468459442059375 0.02635007201346 -0.440363445705636 2.69716836697876e-05 MirTarget;miRNATAP -0.214020878084447 3.70050796114776e-13 NA NA NA hsa-miR-16-5p SNX21 0.468459442059375 0.02635007201346 -0.540682527205882 1.24300208179664e-05 mirMAP -0.233835653067943 2.78434721476866e-11 NA NA NA hsa-miR-16-5p SOCS2 0.468459442059375 0.02635007201346 -1.10044523318765 6.64329026112842e-10 miRNAWalker2_validate -0.277286662580015 1.21924465976696e-07 NA NA NA hsa-miR-16-5p SOCS5 0.468459442059375 0.02635007201346 0.20644658123199 0.0461514915995933 miRNAWalker2_validate -0.295543885074731 7.31003804452774e-28 NA NA NA hsa-miR-16-5p SOGA3 0.468459442059375 0.02635007201346 -1.45935044862323 6.09769266940826e-06 MirTarget -0.995765975533316 5.55453779556235e-32 NA NA NA hsa-miR-16-5p SON 0.468459442059375 0.02635007201346 0.168487112479211 0.0440632380826114 miRNAWalker2_validate;miRNATAP -0.121628659321569 2.80329302836622e-07 NA NA NA hsa-miR-16-5p SOS2 0.468459442059375 0.02635007201346 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.210957704787092 6.34408939150223e-15 NA NA NA hsa-miR-16-5p SOWAHC 0.468459442059375 0.02635007201346 -0.16935987546375 0.304931832982079 miRNAWalker2_validate;MirTarget;miRNATAP -0.192351121977879 4.91156018830248e-05 NA NA NA hsa-miR-16-5p SOX5 0.468459442059375 0.02635007201346 -1.09083873380211 3.82011335261816e-05 miRNATAP -0.511170637199685 1.05021226374744e-11 NA NA NA hsa-miR-16-5p SOX6 0.468459442059375 0.02635007201346 -1.17584817693337 3.33834806230109e-05 MirTarget;miRNATAP -0.268889728322971 0.0012300768567627 24852767 Aberrant expression level of miR-16 could suppress cell apoptosis while promote growth by regulating RECK and SOX6 which play important roles in the pathogenesis of ESCC esophageal cancer hsa-miR-16-5p SSBP2 0.468459442059375 0.02635007201346 -1.58025310656881 5.21464030760244e-12 MirTarget -0.555032183154066 1.85154933732377e-17 NA NA NA hsa-miR-16-5p SSH1 0.468459442059375 0.02635007201346 0.322029052369087 0.00169313379685513 mirMAP -0.171779509987528 3.3840284371741e-09 NA NA NA hsa-miR-16-5p ST8SIA3 0.468459442059375 0.02635007201346 -2.91558860135036 1.52609950297091e-08 MirTarget -0.876080874307762 5.31405341159744e-09 NA NA NA hsa-miR-16-5p STK33 0.468459442059375 0.02635007201346 -0.92864452301099 0.00657026101364563 miRNAWalker2_validate;MirTarget;miRNATAP -0.526616351914148 7.02013541952796e-08 NA NA NA hsa-miR-16-5p STOX2 0.468459442059375 0.02635007201346 -1.38885793271292 7.68761182671221e-06 MirTarget -0.486897992202117 5.8484179083031e-08 NA NA NA hsa-miR-16-5p STX17 0.468459442059375 0.02635007201346 -0.168614977727771 0.0370678702778951 MirTarget -0.13613563005823 1.9103521649482e-09 NA NA NA hsa-miR-16-5p STXBP1 0.468459442059375 0.02635007201346 0.154311510666179 0.485187424704128 MirTarget;miRNATAP -0.187717269903893 0.00333917465408358 NA NA NA hsa-miR-16-5p STYX 0.468459442059375 0.02635007201346 -0.0447871564829079 0.614114876390358 miRNATAP -0.13799633270026 3.29958852908188e-08 NA NA NA hsa-miR-16-5p SWAP70 0.468459442059375 0.02635007201346 -0.0283444386061209 0.810845764431306 MirTarget -0.112040853602413 0.00100186385760347 NA NA NA hsa-miR-16-5p SYDE1 0.468459442059375 0.02635007201346 -0.0640700013959519 0.734826242563291 miRNATAP -0.394459563439924 4.46525828714196e-14 NA NA NA hsa-miR-16-5p SYDE2 0.468459442059375 0.02635007201346 -0.299681486604406 0.195483256134359 miRNATAP -0.667094599743133 2.77408708586741e-28 NA NA NA hsa-miR-16-5p SYNDIG1 0.468459442059375 0.02635007201346 1.56178434055742 5.39669156246686e-07 MirTarget;miRNATAP -0.231630014667531 0.0123191475488677 NA NA NA hsa-miR-16-5p SYNE1 0.468459442059375 0.02635007201346 -0.737828565382011 0.00316151426540844 MirTarget -0.595054740772565 3.87482087339147e-18 NA NA NA hsa-miR-16-5p SYNJ1 0.468459442059375 0.02635007201346 0.099773753433825 0.303608235961315 miRNAWalker2_validate;MirTarget;miRNATAP -0.140373130908645 3.14582003245791e-07 NA NA NA hsa-miR-16-5p SYNPO 0.468459442059375 0.02635007201346 -0.336304575074278 0.0837448668188425 mirMAP -0.36947403998089 1.13858932008819e-11 NA NA NA hsa-miR-16-5p SYT11 0.468459442059375 0.02635007201346 -0.0332651006696336 0.879791327587014 miRNAWalker2_validate -0.501253112748393 7.50783085938362e-17 NA NA NA hsa-miR-16-5p SYT3 0.468459442059375 0.02635007201346 0.198584605183963 0.586926830034396 miRNATAP -0.537849664532372 2.34826281848589e-07 NA NA NA hsa-miR-16-5p SYT4 0.468459442059375 0.02635007201346 -3.20681967154073 1.00295168545729e-07 MirTarget -0.863300323991926 9.97857739657678e-07 NA NA NA hsa-miR-16-5p TACC1 0.468459442059375 0.02635007201346 -0.361657767484704 0.0540556103390073 MirTarget -0.497095187283969 3.61235549189228e-23 NA NA NA hsa-miR-16-5p TAOK1 0.468459442059375 0.02635007201346 0.34222374126551 0.000498972568442839 MirTarget;miRNATAP -0.176537749206081 1.98458293351823e-10 NA NA NA hsa-miR-16-5p TBC1D20 0.468459442059375 0.02635007201346 -0.141869643616188 0.0683752364327144 MirTarget -0.157063372582471 2.2970399144164e-13 NA NA NA hsa-miR-16-5p TBRG1 0.468459442059375 0.02635007201346 -0.0707275916682448 0.373239777663103 miRNAWalker2_validate -0.108957715680883 1.20267378226415e-06 NA NA NA hsa-miR-16-5p TCEA2 0.468459442059375 0.02635007201346 -0.653060587847677 0.00171167383430329 mirMAP -0.228898509755977 0.000152485561389503 NA NA NA hsa-miR-16-5p TCFL5 0.468459442059375 0.02635007201346 0.393616939437025 0.00234199758038093 miRNAWalker2_validate -0.103945982762774 0.00578738868023131 NA NA NA hsa-miR-16-5p TES 0.468459442059375 0.02635007201346 -0.348224082593956 0.00638545187280882 miRNAWalker2_validate -0.226707354868263 3.07666264014068e-10 NA NA NA hsa-miR-16-5p TEX15 0.468459442059375 0.02635007201346 -2.24520433024939 0.0001512669775356 miRNAWalker2_validate -0.686429554328572 7.07471844465324e-05 NA NA NA hsa-miR-16-5p TFDP2 0.468459442059375 0.02635007201346 -0.160784627018407 0.291450213121909 MirTarget;mirMAP -0.386694300759655 3.12973539447999e-21 NA NA NA hsa-miR-16-5p TFPI 0.468459442059375 0.02635007201346 -0.0903165752589947 0.661792991177754 miRNAWalker2_validate -0.261079099581023 9.96681371774086e-06 NA NA NA hsa-miR-16-5p TGFBI 0.468459442059375 0.02635007201346 0.672244292621488 0.00218044324355788 miRNAWalker2_validate -0.261663207988355 3.7773486494115e-05 NA NA NA hsa-miR-16-5p TGFBR3 0.468459442059375 0.02635007201346 -1.17329353105567 5.76332601597347e-06 MirTarget;miRNATAP -0.707341422014863 5.54612652027264e-24 NA NA NA hsa-miR-16-5p THRB 0.468459442059375 0.02635007201346 -1.11745660181354 0.00039648730743052 MirTarget -0.571949367547602 1.7669545460057e-10 NA NA NA hsa-miR-16-5p THSD4 0.468459442059375 0.02635007201346 -1.40005104343222 1.03135805453461e-07 MirTarget -0.425965601079675 2.62505807212949e-08 NA NA NA hsa-miR-16-5p TIA1 0.468459442059375 0.02635007201346 0.551692210838088 1.20297999532581e-05 miRNAWalker2_validate -0.131103785873264 0.000376002250332555 NA NA NA hsa-miR-16-5p TIMP3 0.468459442059375 0.02635007201346 -0.545766258963537 0.0230696906023966 miRNAWalker2_validate -0.509797414891497 2.01308023758019e-14 NA NA NA hsa-miR-16-5p TLE4 0.468459442059375 0.02635007201346 -1.15702818127241 1.2267818242402e-11 miRNAWalker2_validate -0.324285204896589 8.05086119284953e-11 NA NA NA hsa-miR-16-5p TLK1 0.468459442059375 0.02635007201346 -0.0930732141591468 0.237909428876318 miRNAWalker2_validate;MirTarget;miRNATAP -0.175316917223304 2.64724180646716e-16 NA NA NA hsa-miR-16-5p TLL1 0.468459442059375 0.02635007201346 -1.19495000359464 2.51143775869264e-05 miRNATAP -0.57485338487228 7.47291112967837e-13 NA NA NA hsa-miR-16-5p TMCC1 0.468459442059375 0.02635007201346 0.246634162901872 0.00839217828410787 miRNAWalker2_validate;miRNATAP -0.159479683110072 1.43643403384868e-09 NA NA NA hsa-miR-16-5p TMEM100 0.468459442059375 0.02635007201346 -3.27195385316868 6.21442061957714e-15 miRNAWalker2_validate;MirTarget -0.965461946344249 2.80321689302258e-15 NA NA NA hsa-miR-16-5p TMEM109 0.468459442059375 0.02635007201346 -0.278587947088214 0.00410264157255814 miRNAWalker2_validate -0.117512799040572 2.49163302325205e-05 NA NA NA hsa-miR-16-5p TMEM245 0.468459442059375 0.02635007201346 -0.242721302151875 0.0930172579576728 miRNAWalker2_validate;miRNATAP -0.416614766314106 2.19205992663311e-28 NA NA NA hsa-miR-16-5p TMEM43 0.468459442059375 0.02635007201346 0.0145253608400795 0.898804510538956 miRNAWalker2_validate;MirTarget -0.321216235555236 4.65310853296432e-27 NA NA NA hsa-miR-16-5p TMEM55A 0.468459442059375 0.02635007201346 -0.621767832522187 0.00323252275135545 MirTarget -0.570152143900463 6.06405381696272e-24 NA NA NA hsa-miR-16-5p TMTC3 0.468459442059375 0.02635007201346 0.122636432015445 0.221891077515614 miRNAWalker2_validate -0.172882172886055 7.96401989929384e-10 NA NA NA hsa-miR-16-5p TNFAIP8L3 0.468459442059375 0.02635007201346 -1.60070797435006 5.72310426720932e-08 MirTarget -0.664875217965818 1.51366749504143e-15 NA NA NA hsa-miR-16-5p TNRC6B 0.468459442059375 0.02635007201346 0.0200605311980917 0.853993906874431 miRNAWalker2_validate;miRNATAP -0.212229664546089 2.13415167233416e-12 NA NA NA hsa-miR-16-5p TOM1L2 0.468459442059375 0.02635007201346 -0.994181490940386 3.17616240628865e-12 mirMAP -0.26669278539097 1.78009923342539e-10 NA NA NA hsa-miR-16-5p TPBG 0.468459442059375 0.02635007201346 0.369493271529142 0.0785185687561158 miRNAWalker2_validate -0.137656399170544 0.0242836164782855 NA NA NA hsa-miR-16-5p TPM2 0.468459442059375 0.02635007201346 -1.44754409328087 2.79634378563248e-05 MirTarget -0.94863015471608 2.40210147239775e-24 NA NA NA hsa-miR-16-5p TRAF6 0.468459442059375 0.02635007201346 -0.0475358370197787 0.563801051918788 MirTarget -0.133053504945983 7.99894072188029e-09 NA NA NA hsa-miR-16-5p TRIM2 0.468459442059375 0.02635007201346 -0.138593633483852 0.426294696378046 miRNATAP -0.114884466781375 0.0229941273299049 NA NA NA hsa-miR-16-5p TRIM44 0.468459442059375 0.02635007201346 0.233049598119167 0.0170626883391029 miRNAWalker2_validate -0.101563909825474 0.000303841267426099 NA NA NA hsa-miR-16-5p TRIM67 0.468459442059375 0.02635007201346 0.880922933596874 0.000527737940631189 mirMAP -0.21591707897544 0.00369467901470395 NA NA NA hsa-miR-16-5p TRPC1 0.468459442059375 0.02635007201346 -0.704677053980514 0.00534368864806038 MirTarget -0.746361470702179 1.64799367624157e-29 NA NA NA hsa-miR-16-5p TSC22D3 0.468459442059375 0.02635007201346 -1.74603210320545 3.61843236827956e-15 miRNATAP -0.26858579117762 6.95185874755113e-05 NA NA NA hsa-miR-16-5p TSPAN5 0.468459442059375 0.02635007201346 -1.05916819146055 6.72366925707668e-07 MirTarget;miRNATAP -0.135306255205158 0.0326235920061623 NA NA NA hsa-miR-16-5p TSPYL2 0.468459442059375 0.02635007201346 -0.863367135773039 5.20650702866693e-06 MirTarget;miRNATAP -0.391407685702923 2.72823092334046e-13 26640145 First we examined the expression of miR-16 in primary cutaneous T-cell lymphoma CTCL and other non-Hodgkin T/natural killer NK-cell lymphomas and found that miR-16 was downregulated than that in the corresponding normal cells; Notably miR-16 expression was reduced as the primary CTCL progressed from the early stage to the advanced stage; Next we transduced CTCL cells with miR-16 to examine whether this miRNA exhibited tumor-suppressive effects in CTCL cells; Alternatively in CTCL cells lacking functional p53 miR-16 induced compensatory apoptosis; Elucidation of the essential targets of miR-16 and SAHA provides a basis for the clinical application of SAHA in the treatment of CTCL and other non-Hodgkin T/NK-cell lymphomas staging;progression lymphoma hsa-miR-16-5p TTC14 0.468459442059375 0.02635007201346 -0.165834824080406 0.370234160666997 miRNATAP -0.293604723601557 2.09918610074207e-08 NA NA NA hsa-miR-16-5p TTC21B 0.468459442059375 0.02635007201346 0.218949158239465 0.0422280171667745 miRNATAP -0.156970644149879 2.99135102165412e-07 NA NA NA hsa-miR-16-5p TTC25 0.468459442059375 0.02635007201346 -0.207867283825482 0.382608322490927 MirTarget -0.282249799431263 3.65369928658277e-05 NA NA NA hsa-miR-16-5p UBE4B 0.468459442059375 0.02635007201346 -0.234890160403762 0.00699649400950057 MirTarget;miRNATAP -0.185943088507879 8.92131567625205e-15 NA NA NA hsa-miR-16-5p UBL3 0.468459442059375 0.02635007201346 -0.925691828169475 5.01551726319136e-15 MirTarget -0.136976506498242 0.000135164682036558 NA NA NA hsa-miR-16-5p UBR3 0.468459442059375 0.02635007201346 -0.0206777423176625 0.827742242328184 MirTarget;miRNATAP -0.187146405182924 1.00357604876108e-12 NA NA NA hsa-miR-16-5p UBXN10 0.468459442059375 0.02635007201346 -0.722631468061429 0.0447174779262154 MirTarget;miRNATAP -0.610379742544682 2.14688719679611e-09 NA NA NA hsa-miR-16-5p UBXN2B 0.468459442059375 0.02635007201346 0.327813841384824 0.00202369927290284 miRNAWalker2_validate -0.113265106458724 0.00022432639649982 NA NA NA hsa-miR-16-5p UFSP2 0.468459442059375 0.02635007201346 -0.78816433786614 5.31514088671543e-14 miRNAWalker2_validate -0.18814597276805 1.21325377834876e-09 NA NA NA hsa-miR-16-5p ULK1 0.468459442059375 0.02635007201346 -0.179934913251413 0.111381698496373 miRNAWalker2_validate -0.189178192657291 2.75973666206298e-09 NA NA NA hsa-miR-16-5p UNC80 0.468459442059375 0.02635007201346 -1.93440601889881 3.16732101418133e-06 MirTarget;miRNATAP -0.746093000250636 3.85814657851128e-10 NA NA NA hsa-miR-16-5p USP12 0.468459442059375 0.02635007201346 -0.101794564798544 0.407677769454764 MirTarget;miRNATAP -0.239551604400941 2.26772100898242e-12 NA NA NA hsa-miR-16-5p USP2 0.468459442059375 0.02635007201346 -2.19721865185727 1.17166813672625e-12 miRNATAP -0.644407693417875 8.58072640442066e-13 NA NA NA hsa-miR-16-5p USP31 0.468459442059375 0.02635007201346 0.970416721014479 1.34505246312873e-16 MirTarget -0.150295557042634 2.59547027369819e-05 NA NA NA hsa-miR-16-5p USP44 0.468459442059375 0.02635007201346 -0.655521376200348 0.0247774577651161 MirTarget -0.765735253728553 1.5167082184552e-22 NA NA NA hsa-miR-16-5p USP53 0.468459442059375 0.02635007201346 -0.383332121028338 0.00131809074213516 miRNAWalker2_validate;miRNATAP -0.18730987369828 3.70046821714942e-08 NA NA NA hsa-miR-16-5p USP6 0.468459442059375 0.02635007201346 0.187960680685821 0.387097160375696 miRNATAP -0.165324341445257 0.00867809284802911 NA NA NA hsa-miR-16-5p VASN 0.468459442059375 0.02635007201346 0.0664869223566349 0.704313801335507 miRNAWalker2_validate -0.206696467666438 3.8746070379679e-05 NA NA NA hsa-miR-16-5p VAT1 0.468459442059375 0.02635007201346 -0.13395822096223 0.355205390940839 MirTarget;miRNATAP -0.120092706867843 0.00412761026296889 NA NA NA hsa-miR-16-5p VCL 0.468459442059375 0.02635007201346 -0.110736733751609 0.514952145261565 miRNAWalker2_validate -0.498871721586695 1.08134237321109e-29 NA NA NA hsa-miR-16-5p VIM 0.468459442059375 0.02635007201346 -0.315902381310506 0.0583233355839757 miRNAWalker2_validate -0.163866687935272 0.000679944450139554 NA NA NA hsa-miR-16-5p VPS13B 0.468459442059375 0.02635007201346 0.355265011270777 0.00171278261576175 mirMAP -0.15989936862267 8.33295316725262e-07 NA NA NA hsa-miR-16-5p VPS45 0.468459442059375 0.02635007201346 -0.27328327087376 0.000562153109247503 miRNAWalker2_validate -0.109543110124209 1.2895994272735e-06 NA NA NA hsa-miR-16-5p VWF 0.468459442059375 0.02635007201346 0.19886176095982 0.31079150620286 mirMAP -0.151394699339793 0.00774928172095829 NA NA NA hsa-miR-16-5p WBP1L 0.468459442059375 0.02635007201346 -0.377971404363762 8.29956294454323e-05 mirMAP -0.139143565023882 4.48220513869153e-07 NA NA NA hsa-miR-16-5p WDR47 0.468459442059375 0.02635007201346 -0.378252468795409 0.000312581763040392 MirTarget;miRNATAP -0.231647453217504 1.51454150104829e-15 NA NA NA hsa-miR-16-5p WISP1 0.468459442059375 0.02635007201346 2.17483053056854 1.6208081868066e-16 MirTarget -0.250507790939233 0.00203183985626867 NA NA NA hsa-miR-16-5p WNK3 0.468459442059375 0.02635007201346 -0.566384750663729 0.0267756841098298 miRNATAP -0.716867937756067 2.73841059250448e-26 NA NA NA hsa-miR-16-5p WNT9A 0.468459442059375 0.02635007201346 -1.39860250502631 0.000264930163673997 mirMAP -1.03043095990865 2.16591074259425e-23 NA NA NA hsa-miR-16-5p WTIP 0.468459442059375 0.02635007201346 -0.203064079884611 0.334942845307838 mirMAP -0.313767050328655 1.60473825500706e-07 NA NA NA hsa-miR-16-5p XYLT1 0.468459442059375 0.02635007201346 -0.197036506362473 0.248263224443978 miRNAWalker2_validate;mirMAP -0.252517924114033 1.94037494112402e-07 NA NA NA hsa-miR-16-5p ZBTB10 0.468459442059375 0.02635007201346 0.11491226178643 0.650172271983559 MirTarget;miRNATAP -0.381519694241523 1.15731998710913e-07 NA NA NA hsa-miR-16-5p ZBTB44 0.468459442059375 0.02635007201346 0.264727540057518 0.0098977316167743 MirTarget;miRNATAP -0.124151854810438 2.49726964596567e-05 NA NA NA hsa-miR-16-5p ZC2HC1A 0.468459442059375 0.02635007201346 -0.368582106321495 0.049622481836739 MirTarget -0.41596714358493 8.47011671388647e-16 NA NA NA hsa-miR-16-5p ZC3H11A 0.468459442059375 0.02635007201346 0.413459822094182 2.09330575787052e-06 miRNAWalker2_validate -0.10531188165919 3.23302777325017e-05 NA NA NA hsa-miR-16-5p ZC3H12B 0.468459442059375 0.02635007201346 -0.250832462540052 0.257150410374074 miRNATAP -0.489151280924922 8.96765582437468e-16 NA NA NA hsa-miR-16-5p ZC3H12C 0.468459442059375 0.02635007201346 -0.811123594545078 0.000172087654901931 MirTarget -0.292374961726643 2.88023555590377e-06 NA NA NA hsa-miR-16-5p ZC3H13 0.468459442059375 0.02635007201346 0.294905422502363 0.0153515337103235 MirTarget -0.203463220937597 3.32263508939899e-09 NA NA NA hsa-miR-16-5p ZC3H6 0.468459442059375 0.02635007201346 -0.421092141864099 0.00728833157985793 miRNATAP -0.427099897277439 1.57495966260979e-24 NA NA NA hsa-miR-16-5p ZCCHC5 0.468459442059375 0.02635007201346 -0.953061160218104 0.0518339911676993 MirTarget;miRNATAP -1.18224350365735 8.30232387728479e-19 NA NA NA hsa-miR-16-5p ZDHHC15 0.468459442059375 0.02635007201346 -1.35902684957062 3.39400626126344e-06 MirTarget -0.835972197372081 1.71671016110874e-26 NA NA NA hsa-miR-16-5p ZDHHC21 0.468459442059375 0.02635007201346 -0.389259000015898 0.0125589928320564 MirTarget -0.166305179551208 0.000225551941224307 NA NA NA hsa-miR-16-5p ZER1 0.468459442059375 0.02635007201346 -0.843542777878835 2.68084128932977e-18 miRNATAP -0.136662374476317 3.55310173977086e-06 NA NA NA hsa-miR-16-5p ZFHX3 0.468459442059375 0.02635007201346 0.388625553932512 0.0136343956376204 miRNAWalker2_validate;MirTarget;miRNATAP -0.377058644457464 1.63897183645529e-18 NA NA NA hsa-miR-16-5p ZFHX4 0.468459442059375 0.02635007201346 0.0184972294773713 0.955736809911936 MirTarget;miRNATAP -0.840301905618063 7.04076893721668e-21 NA NA NA hsa-miR-16-5p ZFYVE1 0.468459442059375 0.02635007201346 -0.662930192090126 1.00517576029795e-12 MirTarget -0.136815651732616 7.16008815855908e-07 NA NA NA hsa-miR-16-5p ZHX1 0.468459442059375 0.02635007201346 -0.327274762239904 0.00108963461153885 miRNATAP -0.131284165039592 5.05088036926635e-06 NA NA NA hsa-miR-16-5p ZHX3 0.468459442059375 0.02635007201346 -0.48569389286767 0.00067184703404714 mirMAP -0.368219477458294 1.52963857706995e-21 NA NA NA hsa-miR-16-5p ZMAT3 0.468459442059375 0.02635007201346 0.27771952020038 0.0499447683089053 MirTarget -0.250718319575479 3.16552165472125e-10 NA NA NA hsa-miR-16-5p ZMIZ1 0.468459442059375 0.02635007201346 -0.270187558061514 0.0214648981477033 mirMAP -0.199953102737691 1.61306161956236e-09 NA NA NA hsa-miR-16-5p ZMYM2 0.468459442059375 0.02635007201346 0.278969072922853 0.0127298205019214 MirTarget;miRNATAP -0.107216484818975 0.00092400105727866 NA NA NA hsa-miR-16-5p ZNF304 0.468459442059375 0.02635007201346 -0.152735534634012 0.388371916645428 miRNATAP -0.202808882685971 6.65324657232416e-05 NA NA NA hsa-miR-16-5p ZNF346 0.468459442059375 0.02635007201346 -0.180741914324089 0.0261218104301725 MirTarget -0.109114332072606 2.2877423156162e-06 NA NA NA hsa-miR-16-5p ZNF362 0.468459442059375 0.02635007201346 -0.231025493088191 0.0584071488986172 MirTarget;miRNATAP -0.219619044496197 1.42139877511339e-10 NA NA NA hsa-miR-16-5p ZNF423 0.468459442059375 0.02635007201346 -0.207391944090895 0.423116370581353 miRNATAP -0.735653062862581 2.13502992575839e-27 NA NA NA hsa-miR-16-5p ZNF436 0.468459442059375 0.02635007201346 0.0426050131527091 0.706505156892831 miRNATAP -0.23806880506761 1.95870134033813e-14 NA NA NA hsa-miR-16-5p ZNF445 0.468459442059375 0.02635007201346 0.353019491783618 0.00152699832029871 mirMAP -0.189077528040963 2.08714222513004e-09 NA NA NA hsa-miR-16-5p ZNF449 0.468459442059375 0.02635007201346 0.27714056761396 0.0126076680026678 MirTarget;miRNATAP -0.216930582245544 2.53982119554305e-12 NA NA NA hsa-miR-16-5p ZNF512B 0.468459442059375 0.02635007201346 -0.566120168951347 0.0123439167408622 mirMAP -0.212932590216009 0.00119258743821462 NA NA NA hsa-miR-16-5p ZNF516 0.468459442059375 0.02635007201346 -0.530173332560438 0.00170477542591741 mirMAP -0.31458905969333 4.2138822807807e-11 NA NA NA hsa-miR-16-5p ZNF518B 0.468459442059375 0.02635007201346 -0.810348186681662 0.0007591643900906 MirTarget -0.344330536945479 6.74884917462926e-07 NA NA NA hsa-miR-16-5p ZNF532 0.468459442059375 0.02635007201346 0.410685792071696 0.016269152211887 miRNATAP -0.366707843570935 9.31727363552204e-15 NA NA NA hsa-miR-16-5p ZNF559 0.468459442059375 0.02635007201346 -0.387591208206637 0.0421037750846807 miRNAWalker2_validate -0.238358334434327 1.36453928905374e-05 NA NA NA hsa-miR-16-5p ZNF621 0.468459442059375 0.02635007201346 0.327989171873721 0.000586117712565943 mirMAP -0.161927537552933 2.0684525744718e-09 NA NA NA hsa-miR-16-5p ZNF638 0.468459442059375 0.02635007201346 0.219653727561941 0.0121365547102358 miRNAWalker2_validate -0.139668545944673 1.62822024571037e-08 NA NA NA hsa-miR-16-5p ZNF644 0.468459442059375 0.02635007201346 0.311066122067824 0.000229055656772785 miRNAWalker2_validate -0.107956234915893 8.61839277679403e-06 NA NA NA hsa-miR-16-5p ZNF654 0.468459442059375 0.02635007201346 -0.136763612417804 0.16769732511067 MirTarget;miRNATAP -0.151004949583604 6.9869261045331e-08 NA NA NA hsa-miR-16-5p ZNF662 0.468459442059375 0.02635007201346 -1.88043061006014 2.81229008426511e-10 MirTarget -0.713543490872537 2.94726352828946e-17 NA NA NA hsa-miR-16-5p ZNF704 0.468459442059375 0.02635007201346 -0.446994599853389 0.116513806383905 MirTarget -0.455679229844569 1.717454615409e-08 NA NA NA hsa-miR-16-5p ZNF791 0.468459442059375 0.02635007201346 -0.106503770536559 0.279161855371516 miRNAWalker2_validate -0.220534873959054 1.9402934728099e-16 NA NA NA hsa-miR-16-5p ZNF827 0.468459442059375 0.02635007201346 -0.237884564535214 0.159114228091213 miRNAWalker2_validate -0.243762825335322 4.06827072685531e-07 NA NA NA hsa-miR-16-5p ZRANB1 0.468459442059375 0.02635007201346 -0.162987253940597 0.104519813914062 miRNAWalker2_validate -0.197768808324089 1.20008165314785e-12 NA NA NA hsa-miR-16-5p ZYX 0.468459442059375 0.02635007201346 0.0190993450459676 0.897633139069276 miRNAWalker2_validate;miRTarBase;miRNATAP -0.203714199850782 1.44088880610258e-06 NA NA NA