miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-22-3p AGBL5 0.0468440219945929 0.967778504781139 0.0905910037581368 0.874374000695286 MirTarget;miRNATAP -0.161406284451993 5.00904836697278e-06 NA NA NA hsa-miR-22-3p ARC 0.0468440219945929 0.967778504781139 -0.248282159806999 0.596661730587338 mirMAP -0.312350115041477 0.00365307407055968 NA NA NA hsa-miR-22-3p BCL9 0.0468440219945929 0.967778504781139 -0.0473050382855567 0.938907861608285 MirTarget;miRNATAP -0.131996543193398 0.000532954631801289 NA NA NA hsa-miR-22-3p BMP7 0.0468440219945929 0.967778504781139 0.867122741702786 0.271084009545316 miRNAWalker2_validate;miRTarBase -0.314121211679014 0.0275650894839941 NA NA NA hsa-miR-22-3p BRSK2 0.0468440219945929 0.967778504781139 -0.33402149332374 0.545031240280552 MirTarget;miRNATAP -0.30350337202271 0.0153626247895106 NA NA NA hsa-miR-22-3p BTF3 0.0468440219945929 0.967778504781139 0.255177379923879 0.728792707057093 miRNAWalker2_validate -0.220582679250491 9.35024782409572e-10 NA NA NA hsa-miR-22-3p CDCA7L 0.0468440219945929 0.967778504781139 0.0900202816109656 0.865363255653899 MirTarget -0.18479337381065 0.000143282192721079 NA NA NA hsa-miR-22-3p CENPV 0.0468440219945929 0.967778504781139 0.115471172764651 0.772077028099417 MirTarget -0.262664993383004 0.00232139696998833 NA NA NA hsa-miR-22-3p CLUAP1 0.0468440219945929 0.967778504781139 -0.00326639480893487 0.99355209405024 mirMAP -0.222504968840014 2.15825624973182e-11 NA NA NA hsa-miR-22-3p CUL3 0.0468440219945929 0.967778504781139 -0.0233263194948385 0.966605304803416 miRNATAP -0.107787075359271 1.24554633466499e-06 NA NA NA hsa-miR-22-3p DAD1 0.0468440219945929 0.967778504781139 0.0956804418908277 0.884983730532249 MirTarget -0.105123066940079 0.00206122522185403 NA NA NA hsa-miR-22-3p DNAJC27 0.0468440219945929 0.967778504781139 -0.106141068710585 0.698089779114498 MirTarget -0.112311411407639 8.39914262174449e-05 NA NA NA hsa-miR-22-3p DPF2 0.0468440219945929 0.967778504781139 0.00237745456848337 0.996715690436653 MirTarget;miRNATAP -0.106303351689186 2.08017784703879e-06 NA NA NA hsa-miR-22-3p DPY30 0.0468440219945929 0.967778504781139 0.425705805428714 0.419534780417793 MirTarget -0.131887431399372 0.000107622916648275 NA NA NA hsa-miR-22-3p EFR3B 0.0468440219945929 0.967778504781139 -0.184292387875329 0.600415783873846 MirTarget -0.242660001442657 0.00133319399287846 NA NA NA hsa-miR-22-3p GATM 0.0468440219945929 0.967778504781139 0.0952376258924255 0.820377695068492 MirTarget -0.174815664841574 0.00425658701604071 NA NA NA hsa-miR-22-3p GPBP1 0.0468440219945929 0.967778504781139 -0.0295484367138661 0.957497175654481 MirTarget;miRNATAP -0.107909576703091 9.54312937441129e-05 NA NA NA hsa-miR-22-3p HDAC4 0.0468440219945929 0.967778504781139 -0.275592349037378 0.542250148863867 miRNAWalker2_validate;miRTarBase;miRNATAP -0.123918964828771 0.00279384427648962 20842113 Furthermore histone deacetylase 4 HDAC4 known to have critical roles in cancer development was proved to be directly targeted and regulated by miR-22; Furthermore HDAC4 was upregulated in miR-22-downregulated HCC tissues suggesting that downregulation of miR-22 might participate in HCC carcinogenesis and progression through potentiation of HDAC4 expression progression;tumorigenesis liver cancer hsa-miR-22-3p HMGB1 0.0468440219945929 0.967778504781139 0.0376071736611054 0.957155680367252 miRNAWalker2_validate -0.112621671900166 4.10533914896381e-05 24609901;24752578 However possibly as a compensatory effect miR-22 was also upregulated during the chemotherapy and the overexpressed miR-22 targeted the 3' UTR of HMGB1 and inhibits the HMGB1-promoted autophagy; Our study suggests a complexity in the regulation of autophagy by miR-22 and HMGB1 during chemotherapy resistance in osteosarcoma;In this study we determined the targeting role of miR-22 to HMGB1 and the regulation of miR-22 on the HMGB1-mediated cell autophagy and on the cell proliferation migration and invasion of osteosarcoma cells drug resistance; sarcoma;sarcoma hsa-miR-22-3p IL17RD 0.0468440219945929 0.967778504781139 -0.0837567037988727 0.870962136224886 MirTarget;miRNATAP -0.300302259370387 9.64911303374779e-07 NA NA NA hsa-miR-22-3p JARID2 0.0468440219945929 0.967778504781139 -0.188189262266655 0.679298581855395 miRNATAP -0.174613800929565 3.93215635377854e-05 NA NA NA hsa-miR-22-3p KCNC1 0.0468440219945929 0.967778504781139 0.0449547611912151 0.929136954680909 miRNATAP -0.362789626503336 0.000294608788651507 NA NA NA hsa-miR-22-3p KIAA1257 0.0468440219945929 0.967778504781139 -0.176569610521038 0.605655150830703 mirMAP -0.285836979569127 0.00021029791594567 NA NA NA hsa-miR-22-3p KIF6 0.0468440219945929 0.967778504781139 -0.18634088212664 0.56919306846748 mirMAP -0.199720537693854 0.00571370946047905 NA NA NA hsa-miR-22-3p KIRREL3 0.0468440219945929 0.967778504781139 -0.26770541854455 0.650274388437893 MirTarget;miRNATAP -0.72484556173782 2.18005714700607e-08 NA NA NA hsa-miR-22-3p LEMD3 0.0468440219945929 0.967778504781139 0.222015168643809 0.612892589332979 miRNAWalker2_validate -0.105393272709764 1.3457383311654e-05 NA NA NA hsa-miR-22-3p LIG3 0.0468440219945929 0.967778504781139 -0.137909619388092 0.755487948338071 MirTarget -0.121992596997723 0.000162584482523215 NA NA NA hsa-miR-22-3p MAGI2 0.0468440219945929 0.967778504781139 -0.00790751687369751 0.980258124097068 MirTarget -0.14276229279922 0.00116937953752452 NA NA NA hsa-miR-22-3p MAOA 0.0468440219945929 0.967778504781139 0.216267758614028 0.608331488431146 miRNAWalker2_validate;miRTarBase -0.160485811449646 0.026734024832982 NA NA NA hsa-miR-22-3p MECOM 0.0468440219945929 0.967778504781139 0.104531166144888 0.866398503213567 miRNATAP -0.175139796434344 0.0019815004335689 NA NA NA hsa-miR-22-3p NHP2 0.0468440219945929 0.967778504781139 0.277553057333573 0.637211429118291 MirTarget -0.158469560721771 1.27373153233441e-05 NA NA NA hsa-miR-22-3p NUDT4 0.0468440219945929 0.967778504781139 0.306947231961959 0.516273454611005 MirTarget;miRNATAP -0.147501991692451 0.00125398914911248 NA NA NA hsa-miR-22-3p PBX1 0.0468440219945929 0.967778504781139 0.164340803932783 0.807580076898079 MirTarget -0.194138411567884 2.28566196281606e-08 NA NA NA hsa-miR-22-3p PEX5 0.0468440219945929 0.967778504781139 -0.0541579382911079 0.912996954225504 miRNAWalker2_validate -0.143455706822147 5.33700341873953e-06 NA NA NA hsa-miR-22-3p PHC1 0.0468440219945929 0.967778504781139 -0.279352782259429 0.570528372205872 MirTarget -0.169895225365525 8.61064829626614e-05 NA NA NA hsa-miR-22-3p PLAGL2 0.0468440219945929 0.967778504781139 -0.0546141513819354 0.929591181369687 miRNATAP -0.123141158737007 0.00339634039869923 NA NA NA hsa-miR-22-3p PLCXD3 0.0468440219945929 0.967778504781139 -0.58817649532739 0.365923835413038 miRNATAP -0.441334849824991 0.00309393608330694 NA NA NA hsa-miR-22-3p PLEKHG4B 0.0468440219945929 0.967778504781139 -0.659296318691375 0.213793905576961 mirMAP -0.296512723893384 0.000168033363815604 NA NA NA hsa-miR-22-3p POGK 0.0468440219945929 0.967778504781139 -0.0115733232792978 0.984631863182894 MirTarget -0.106293973298418 5.50193946966233e-06 NA NA NA hsa-miR-22-3p PRRT2 0.0468440219945929 0.967778504781139 -0.0449048418559226 0.897651077368752 miRNATAP -0.237381412769232 0.000688433381415815 NA NA NA hsa-miR-22-3p PTMS 0.0468440219945929 0.967778504781139 0.187086412232667 0.812010182196003 miRNAWalker2_validate;miRTarBase -0.124840407541086 0.0013541898063031 NA NA NA hsa-miR-22-3p RAB28 0.0468440219945929 0.967778504781139 0.00500086875734862 0.989445493140187 MirTarget -0.111651977506877 0.000206839632654452 NA NA NA hsa-miR-22-3p RBMXL1 0.0468440219945929 0.967778504781139 -0.0941880589804507 0.855311454757308 MirTarget -0.140543678077435 1.70207005398913e-08 NA NA NA hsa-miR-22-3p RPL13 0.0468440219945929 0.967778504781139 0.469948641246376 0.603572845225541 MirTarget -0.215032481224803 4.74533011463888e-06 NA NA NA hsa-miR-22-3p RPL24 0.0468440219945929 0.967778504781139 0.415560459468432 0.57289919111451 miRNAWalker2_validate -0.277610536501522 1.9402199991847e-11 NA NA NA hsa-miR-22-3p RPL35A 0.0468440219945929 0.967778504781139 0.44763490166746 0.594886845159278 miRNAWalker2_validate -0.235740012790426 3.3788657477439e-07 NA NA NA hsa-miR-22-3p RPS2 0.0468440219945929 0.967778504781139 0.213947913171545 0.803508778963472 miRNAWalker2_validate -0.189248939791968 1.88820904528945e-06 NA NA NA hsa-miR-22-3p RPS4X 0.0468440219945929 0.967778504781139 0.32392101190641 0.735179813082882 miRNAWalker2_validate -0.264971624015455 6.85886693619226e-10 NA NA NA hsa-miR-22-3p RPSA 0.0468440219945929 0.967778504781139 0.292708372647978 0.663661434401365 miRNAWalker2_validate -0.197954807985867 6.81912112983427e-06 NA NA NA hsa-miR-22-3p RSBN1 0.0468440219945929 0.967778504781139 -0.154708510116565 0.73194302907544 MirTarget;miRNATAP -0.166822654456481 1.21040636980985e-10 NA NA NA hsa-miR-22-3p SCYL3 0.0468440219945929 0.967778504781139 0.0612511438713583 0.869363850106949 MirTarget -0.10725537783532 1.54861884640002e-06 NA NA NA hsa-miR-22-3p SEPHS1 0.0468440219945929 0.967778504781139 0.0662487242888234 0.904108420401142 MirTarget;miRNATAP -0.111041371404203 0.00126639968327824 NA NA NA hsa-miR-22-3p SESN1 0.0468440219945929 0.967778504781139 0.218778816354514 0.568533794057563 MirTarget -0.169381889173291 6.98725445868371e-07 NA NA NA hsa-miR-22-3p SLC39A10 0.0468440219945929 0.967778504781139 -0.0324057610934929 0.951393362723483 miRNATAP -0.185979454436773 4.48512311416522e-06 NA NA NA hsa-miR-22-3p SOX13 0.0468440219945929 0.967778504781139 0.0392133635488072 0.9463522475342 MirTarget -0.136850954214571 0.00107632006108242 NA NA NA hsa-miR-22-3p SYT13 0.0468440219945929 0.967778504781139 -0.997651837798931 0.0654304331964072 MirTarget -0.338638562445918 0.00187793106996169 NA NA NA hsa-miR-22-3p TCEAL1 0.0468440219945929 0.967778504781139 0.0575213883378725 0.883812788871275 miRNAWalker2_validate;miRTarBase -0.139556325471307 5.46840949616891e-06 NA NA NA hsa-miR-22-3p TMEM155 0.0468440219945929 0.967778504781139 0.119838378084 0.786499074825218 MirTarget -0.279643570185876 0.00214483328258017 NA NA NA hsa-miR-22-3p TMSB15B 0.0468440219945929 0.967778504781139 -0.56272692642928 0.161491437086946 MirTarget -0.354955263632488 0.000109650093763054 NA NA NA hsa-miR-22-3p TP73 0.0468440219945929 0.967778504781139 -0.344008159401897 0.412099831484199 mirMAP -0.312057040050556 0.0007192821797829 NA NA NA hsa-miR-22-3p TRIM13 0.0468440219945929 0.967778504781139 0.262542294186431 0.543661979211902 MirTarget -0.112757313383984 2.89174152457273e-05 NA NA NA hsa-miR-22-3p TRIM46 0.0468440219945929 0.967778504781139 -0.190343616955162 0.567899456007158 MirTarget -0.115349673456273 0.0482677342328698 NA NA NA hsa-miR-22-3p TRUB1 0.0468440219945929 0.967778504781139 0.37968833000394 0.425876794753803 MirTarget;miRNATAP -0.110109165329879 0.000138639232247675 NA NA NA hsa-miR-22-3p UNC119B 0.0468440219945929 0.967778504781139 -0.255073342962268 0.619309549823191 MirTarget -0.231976303547296 2.73852140812855e-09 NA NA NA hsa-miR-22-3p WARS2 0.0468440219945929 0.967778504781139 -0.00471030719604126 0.991039475433535 MirTarget -0.138942763905713 1.80059737338802e-05 NA NA NA hsa-miR-22-3p WASF1 0.0468440219945929 0.967778504781139 0.321904576132275 0.468217747135163 MirTarget;miRNATAP -0.222873973715986 0.000105546604315301 NA NA NA hsa-miR-22-3p WNK2 0.0468440219945929 0.967778504781139 -0.518842596009533 0.362307003157139 mirMAP -0.230174916203687 0.00769953195455595 NA NA NA hsa-miR-22-3p ZBTB39 0.0468440219945929 0.967778504781139 -0.163582166006159 0.689871027901515 MirTarget;miRNATAP -0.137355704231596 6.01182685340217e-05 NA NA NA hsa-miR-22-3p ZFYVE9 0.0468440219945929 0.967778504781139 -0.160956630328475 0.734837632244252 MirTarget;miRNATAP -0.101503141425988 0.00357217891540455 NA NA NA