miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p CACNA2D1 -1.42015538786275 7.03375209382673e-13 3.31556565717047 8.68804644381516e-07 mirMAP -0.501565939634551 0.00220543133729437 NA NA NA hsa-miR-103a-3p CACNA2D1 -1.44083190496857 1.53799939616428e-13 3.31556565717047 8.68804644381516e-07 miRNATAP -1.48785077349547 6.0237211069224e-21 NA NA NA hsa-miR-107 CACNA2D1 -1.30977326593435 1.30372468603976e-11 3.31556565717047 8.68804644381516e-07 PITA;miRanda;miRNATAP -0.850009099829736 3.32378967489299e-07 NA NA NA hsa-miR-126-5p CACNA2D1 -0.895338176458417 2.33372756450718e-05 3.31556565717047 8.68804644381516e-07 mirMAP -0.600254700228478 0.000112468607518709 NA NA NA hsa-miR-141-3p CACNA2D1 -5.02396127982626 2.19224509139725e-24 3.31556565717047 8.68804644381516e-07 TargetScan -0.712756989651708 1.52663401986901e-34 NA NA NA hsa-miR-16-2-3p CACNA2D1 -2.31623086727196 4.29838149388219e-20 3.31556565717047 8.68804644381516e-07 mirMAP -0.782545784623107 2.05271692877172e-10 NA NA NA hsa-miR-16-5p CACNA2D1 -1.75824877145856 1.6859244003313e-16 3.31556565717047 8.68804644381516e-07 miRNAWalker2_validate -1.08911793067024 9.35619842739922e-14 NA NA NA hsa-miR-181a-5p CACNA2D1 -2.29556023480783 1.8138457900616e-21 3.31556565717047 8.68804644381516e-07 mirMAP -0.884406338388322 4.53767756129163e-12 NA NA NA hsa-miR-181b-5p CACNA2D1 -2.49307679431292 3.92829250217676e-20 3.31556565717047 8.68804644381516e-07 mirMAP -0.736518754418169 1.14952057177369e-10 NA NA NA hsa-miR-181c-5p CACNA2D1 -1.58587920618301 1.57506918816936e-10 3.31556565717047 8.68804644381516e-07 mirMAP -0.804099876932157 4.05914355054464e-10 NA NA NA hsa-miR-182-5p CACNA2D1 -3.53923166221814 5.07781258121651e-21 3.31556565717047 8.68804644381516e-07 miRNATAP -0.802351589400528 3.37596704110403e-24 NA NA NA hsa-miR-200b-3p CACNA2D1 -3.78235093249346 3.18343003239465e-14 3.31556565717047 8.68804644381516e-07 TargetScan -0.558131952404015 9.34932566571118e-20 NA NA NA hsa-miR-21-3p CACNA2D1 -2.19296355304363 4.63665722759841e-15 3.31556565717047 8.68804644381516e-07 mirMAP -0.229854553264544 0.0450676471741408 NA NA NA hsa-miR-23a-3p CACNA2D1 -1.00493340843378 2.55313889288964e-08 3.31556565717047 8.68804644381516e-07 mirMAP -0.728701508423108 6.0457829398764e-05 NA NA NA hsa-miR-26b-5p CACNA2D1 -0.885393662798421 3.21162979616316e-06 3.31556565717047 8.68804644381516e-07 mirMAP -1.15675019556576 1.02115069413824e-11 NA NA NA hsa-miR-3065-5p CACNA2D1 -2.74629919868982 1.86846589298284e-08 3.31556565717047 8.68804644381516e-07 mirMAP -0.279071182891583 0.000598495453373106 NA NA NA hsa-miR-30d-3p CACNA2D1 -0.977747550180601 4.3048212205381e-05 3.31556565717047 8.68804644381516e-07 mirMAP -0.92428032510285 7.39868661091689e-12 NA NA NA hsa-miR-30e-3p CACNA2D1 0.215663037684514 0.235375122783534 3.31556565717047 8.68804644381516e-07 mirMAP -0.532160375344364 0.00390194546161315 NA NA NA hsa-miR-32-3p CACNA2D1 -2.02436999565685 5.94091197945307e-09 3.31556565717047 8.68804644381516e-07 mirMAP -0.524056657040928 6.70283139845306e-07 NA NA NA hsa-miR-330-3p CACNA2D1 -0.876747334239085 0.000737090160897034 3.31556565717047 8.68804644381516e-07 mirMAP -0.73097750778254 5.19255290752127e-09 NA NA NA hsa-miR-335-3p CACNA2D1 -3.08791651139852 5.31309869723529e-12 3.31556565717047 8.68804644381516e-07 mirMAP -0.340604402201203 1.69239744785605e-06 NA NA NA hsa-miR-33a-3p CACNA2D1 -1.72765312072219 1.51784443453521e-07 3.31556565717047 8.68804644381516e-07 mirMAP -0.402930843814106 0.000206271529316002 NA NA NA hsa-miR-362-3p CACNA2D1 -2.0756816987665 3.89026064579331e-12 3.31556565717047 8.68804644381516e-07 miRanda -0.379138984947906 0.000651376113281055 NA NA NA hsa-miR-450b-5p CACNA2D1 -1.69244418548325 1.68064054148878e-10 3.31556565717047 8.68804644381516e-07 mirMAP -0.351321354277322 0.00410187305860754 NA NA NA hsa-miR-508-3p CACNA2D1 -1.05493034310846 0.0393857095042517 3.31556565717047 8.68804644381516e-07 mirMAP -0.172707091944874 0.00869230454895343 NA NA NA hsa-miR-576-5p CACNA2D1 -2.20467023993663 3.40534751937985e-19 3.31556565717047 8.68804644381516e-07 mirMAP -1.08389391888318 2.13377876040378e-18 NA NA NA hsa-miR-590-3p CACNA2D1 -2.59289455139753 1.03200520972027e-21 3.31556565717047 8.68804644381516e-07 mirMAP -0.726424682141574 6.02713034583947e-10 NA NA NA hsa-miR-7-1-3p CACNA2D1 -1.84950311431067 1.25300363397659e-13 3.31556565717047 8.68804644381516e-07 mirMAP -0.565041660450894 1.04002683833383e-05 NA NA NA hsa-miR-944 CACNA2D1 -2.91186649218281 1.31574753528145e-06 3.31556565717047 8.68804644381516e-07 mirMAP -0.397325104652847 2.86860290506928e-13 NA NA NA hsa-miR-96-5p CACNA2D1 -4.89433085814374 1.92000659886978e-31 3.31556565717047 8.68804644381516e-07 TargetScan;miRNATAP -0.730547720605139 5.07955475272319e-25 NA NA NA hsa-let-7a-2-3p CCNG2 -0.0400317820791161 0.91528727576685 -0.294593163175016 0.224850601777417 MirTarget -0.188300071549428 1.469681835993e-09 NA NA NA hsa-let-7b-3p CCNG2 -0.868207752019622 1.30460056774367e-05 -0.294593163175016 0.224850601777417 MirTarget;mirMAP -0.148895915715117 0.0115765379259314 NA NA NA hsa-let-7f-1-3p CCNG2 -1.55054488387679 7.31326775537952e-11 -0.294593163175016 0.224850601777417 MirTarget;mirMAP -0.17426620141391 0.000452710207736509 NA NA NA hsa-miR-1271-5p CCNG2 -0.970418832993172 0.000609742584380688 -0.294593163175016 0.224850601777417 MirTarget -0.135322770237981 0.00106266066652335 NA NA NA hsa-miR-142-5p CCNG2 -1.17581605694505 0.00181747019912344 -0.294593163175016 0.224850601777417 MirTarget;miRNATAP -0.176085484773735 7.75837129278938e-09 NA NA NA hsa-miR-146b-5p CCNG2 -1.75587235896723 1.15724631266667e-07 -0.294593163175016 0.224850601777417 miRNATAP -0.27020803241081 1.23701917372016e-15 NA NA NA hsa-miR-193a-3p CCNG2 -1.60460546928078 2.8616979332299e-07 -0.294593163175016 0.224850601777417 miRanda -0.129094145694519 0.000475999179918851 NA NA NA hsa-miR-21-5p CCNG2 -2.73773305747971 1.388649821396e-43 -0.294593163175016 0.224850601777417 mirMAP -0.174747091120676 0.00112665544893574 NA NA NA hsa-miR-29a-5p CCNG2 -1.46749674755271 3.3460500427029e-07 -0.294593163175016 0.224850601777417 mirMAP -0.206679112326703 1.00351662471714e-06 NA NA NA hsa-miR-340-5p CCNG2 -0.30282999308409 0.15774478951913 -0.294593163175016 0.224850601777417 MirTarget;mirMAP -0.205624430662132 0.000184435874836499 27374211 MicroRNA 340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2; Notably alteration of miR-340 expression affected the luciferase activity of wild-type 3'-UTR of cyclin G2 CCNG2 and regulated CCNG2 abundance in gastric cancer cells indicating that CCNG2 is a direct target of miR-340; Moreover CCNG2 knockdown eradicated the effects of miR-340 silencing on gastric cancer cells gastric cancer hsa-miR-342-3p CCNG2 -1.49115144672245 1.43879249744627e-07 -0.294593163175016 0.224850601777417 miRanda -0.146971916288753 0.000310344981815528 NA NA NA hsa-miR-485-3p CCNG2 -0.442820096243913 0.166634696770946 -0.294593163175016 0.224850601777417 MirTarget;mirMAP -0.115099732985913 0.00184797783339564 NA NA NA hsa-miR-655-3p CCNG2 -0.485339318272147 0.137014658258733 -0.294593163175016 0.224850601777417 MirTarget -0.124045178250952 0.000684463971107448 NA NA NA hsa-miR-107 CD47 -1.30977326593435 1.30372468603976e-11 0.164318188512453 0.480797231316321 miRanda -0.204832088691244 0.000338322562998118 NA NA NA hsa-miR-126-5p CD47 -0.895338176458417 2.33372756450718e-05 0.164318188512453 0.480797231316321 mirMAP -0.163704624293122 0.00204770911429088 NA NA NA hsa-miR-149-5p CD47 -2.94200492826326 4.93436498919057e-14 0.164318188512453 0.480797231316321 miRNATAP -0.141333233168055 3.04886219173605e-07 NA NA NA hsa-miR-182-5p CD47 -3.53923166221814 5.07781258121651e-21 0.164318188512453 0.480797231316321 MirTarget;miRNATAP -0.13449272547477 1.85234112980256e-06 NA NA NA hsa-miR-200a-3p CD47 -4.59434485520731 6.38952518573476e-18 0.164318188512453 0.480797231316321 miRNATAP -0.131858123810319 2.67399911076949e-11 NA NA NA hsa-miR-28-5p CD47 -0.230152919654903 0.0742909586754879 0.164318188512453 0.480797231316321 miRanda -0.350017724326003 9.53457323530239e-05 NA NA NA hsa-miR-32-3p CD47 -2.02436999565685 5.94091197945307e-09 0.164318188512453 0.480797231316321 mirMAP -0.14504497560274 5.84097826261096e-05 NA NA NA hsa-miR-320a CD47 -0.43816582801708 0.0390159073347149 0.164318188512453 0.480797231316321 miRanda -0.209040750035783 8.45624540113649e-05 NA NA NA hsa-miR-326 CD47 -0.715313016136041 0.0610265683213364 0.164318188512453 0.480797231316321 MirTarget;miRanda -0.110439682353585 0.000179051768315227 NA NA NA hsa-miR-330-3p CD47 -0.876747334239085 0.000737090160897034 0.164318188512453 0.480797231316321 miRNATAP -0.227783322233916 9.97859211170668e-08 NA NA NA hsa-miR-330-5p CD47 -1.15100069700871 4.85551805046024e-07 0.164318188512453 0.480797231316321 MirTarget;miRanda -0.115262259831607 0.0184995409608 NA NA NA hsa-miR-33a-3p CD47 -1.72765312072219 1.51784443453521e-07 0.164318188512453 0.480797231316321 miRNATAP -0.175874372475287 1.72977382067637e-06 NA NA NA hsa-miR-34a-5p CD47 -1.90163234525649 1.43092834643609e-14 0.164318188512453 0.480797231316321 miRNATAP -0.203358997192752 3.63715466188499e-06 NA NA NA hsa-miR-374a-5p CD47 -0.484615721953736 0.0042981729815149 0.164318188512453 0.480797231316321 mirMAP;miRNATAP -0.206471894373239 0.00209136855325981 NA NA NA hsa-miR-425-5p CD47 -3.07071373939774 4.02947460586131e-25 0.164318188512453 0.480797231316321 MirTarget -0.128916203238761 0.000302705709925772 NA NA NA hsa-miR-497-5p CD47 -0.0257087130056273 0.918145413833362 0.164318188512453 0.480797231316321 MirTarget -0.133763293626654 0.00311577539772363 NA NA NA hsa-miR-505-5p CD47 -1.89243395287645 9.82003586561819e-12 0.164318188512453 0.480797231316321 miRNATAP -0.138591498661449 0.000454489952346527 NA NA NA hsa-miR-769-3p CD47 -2.19896922202687 5.69250370895059e-12 0.164318188512453 0.480797231316321 PITA -0.147541153603909 2.84032078701557e-05 NA NA NA hsa-miR-940 CD47 -3.21011374578759 2.7923171128495e-14 0.164318188512453 0.480797231316321 PITA;miRNATAP -0.149247795783884 8.24707997051351e-08 NA NA NA hsa-miR-96-5p CD47 -4.89433085814374 1.92000659886978e-31 0.164318188512453 0.480797231316321 miRNATAP -0.110138112080723 1.37713513162333e-05 NA NA NA hsa-miR-101-3p CDK6 -0.522819989585457 0.00375627731618062 0.774202349805119 0.064787030605636 mirMAP -0.728162460077577 6.25283110395347e-11 NA NA NA hsa-miR-103a-3p CDK6 -1.44083190496857 1.53799939616428e-13 0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRNATAP -0.738308002788887 9.81610683337994e-14 NA NA NA hsa-miR-106a-5p CDK6 -2.48882002962836 1.99757727374524e-12 0.774202349805119 0.064787030605636 mirMAP -0.23817017599031 1.76828696872453e-05 NA NA NA hsa-miR-106b-5p CDK6 -2.46782146831112 1.36171495805632e-23 0.774202349805119 0.064787030605636 mirMAP -0.506703206296417 3.6460930000884e-11 NA NA NA hsa-miR-107 CDK6 -1.30977326593435 1.30372468603976e-11 0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.535825292120497 1.58523365512466e-07 19407485;22491216;21264532;19688090 Enforced expression of miR-107 in MiaPACA-2 and PANC-1 cells downregulated in vitro growth and this was associated with repression of the putative miR-107 target cyclin-dependent kinase 6 thereby providing a functional basis for the epigenetic inactivation of this miRNA in pancreatic cancer;Levels of known miR-107 targets protein kinase Cε PKCε cyclin-dependent kinase 6 CDK6 and hypoxia-inducible factor 1-β HIF1-β decreased following NP/pre-miR-107 treatment;We have identified miR-107 as a potential regulator of CDK6 expression; A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3' untranslated region; Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression; miR-107 could significantly suppress CDK6 3' UTR luciferase reporter activity and this effect was not detectable when the putative 3' UTR target site was mutated; Consistent with the results of the reporter assay ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 inhibited proliferation induced G1 cell cycle arrest and blocked invasion of the gastric cancer cells; Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells;Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 ;;; pancreatic cancer;head and neck cancer;gastric cancer;lung squamous cell cancer hsa-miR-140-3p CDK6 -0.0608890720479316 0.727716871248732 0.774202349805119 0.064787030605636 miRNATAP -0.253248000876385 0.0322057044568859 NA NA NA hsa-miR-141-3p CDK6 -5.02396127982626 2.19224509139725e-24 0.774202349805119 0.064787030605636 TargetScan;miRNATAP -0.280860480145549 9.29496321423746e-14 NA NA NA hsa-miR-148b-3p CDK6 -1.97815018171325 6.07715327281722e-26 0.774202349805119 0.064787030605636 mirMAP -0.689303354555952 6.39464837566244e-12 NA NA NA hsa-miR-148b-5p CDK6 -2.18024067300781 2.84770452413269e-14 0.774202349805119 0.064787030605636 mirMAP -0.337506526013873 2.86415828815712e-06 NA NA NA hsa-miR-15a-5p CDK6 -2.34669284378787 1.69544424500246e-23 0.774202349805119 0.064787030605636 miRNATAP -0.331153083238962 5.09100262040034e-05 NA NA NA hsa-miR-16-1-3p CDK6 -2.56983217111073 3.02262181237947e-20 0.774202349805119 0.064787030605636 mirMAP -0.214448709710321 0.00270430071750274 NA NA NA hsa-miR-16-5p CDK6 -1.75824877145856 1.6859244003313e-16 0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase -0.211183753760106 0.0224108751050014 NA NA NA hsa-miR-17-5p CDK6 -3.2710598467455 9.93128340539491e-27 0.774202349805119 0.064787030605636 TargetScan;mirMAP -0.168193833076577 0.00702167500067962 NA NA NA hsa-miR-182-5p CDK6 -3.53923166221814 5.07781258121651e-21 0.774202349805119 0.064787030605636 mirMAP -0.342809938093979 8.28135113019132e-12 NA NA NA hsa-miR-185-5p CDK6 -2.34016206907488 1.17481626642041e-26 0.774202349805119 0.064787030605636 miRNAWalker2_validate -0.418001590004214 1.44577313582161e-06 19688090 Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 lung squamous cell cancer hsa-miR-191-5p CDK6 -2.30038190670663 9.93191704546105e-17 0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase -0.711524835034044 1.00464473356187e-26 NA NA NA hsa-miR-200a-3p CDK6 -4.59434485520731 6.38952518573476e-18 0.774202349805119 0.064787030605636 miRNATAP -0.336691687165474 2.80396820395637e-22 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 -3.78235093249346 3.18343003239465e-14 0.774202349805119 0.064787030605636 mirMAP -0.361406013032565 5.1342063993974e-22 NA NA NA hsa-miR-200c-3p CDK6 -3.50132673580081 2.42716349086972e-15 0.774202349805119 0.064787030605636 mirMAP -0.320385878451071 9.82419842455136e-14 NA NA NA hsa-miR-20a-5p CDK6 -3.1557793361919 4.19753346442488e-25 0.774202349805119 0.064787030605636 mirMAP -0.188851341814342 0.00261077138275469 NA NA NA hsa-miR-20b-5p CDK6 -2.07706563022469 1.10107236083434e-05 0.774202349805119 0.064787030605636 mirMAP -0.293918462449454 1.28039252847365e-12 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-218-5p CDK6 0.573801507392186 0.0551983860126695 0.774202349805119 0.064787030605636 miRNAWalker2_validate -0.153512643208175 0.0240408053920225 23996750 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions P<0.05; The low-expression of miR-218 is correlated with malignant clinicopathological characteristics of HCC and miR-218 may inhibit cell proliferation and promote cell apoptosis by down-regulating Bmi-1 and CDK6 in HCC malignant trasformation liver cancer hsa-miR-29b-3p CDK6 -1.65828197923813 1.02676780888145e-09 0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.224461155748557 0.0022317971289129 23245396;25472644;26180082;23591808;27230400;20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; melanoma;colorectal cancer;glioblastoma;lung cancer;sarcoma;lymphoma hsa-miR-29c-3p CDK6 0.00968972577705429 0.97099586346872 0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.580639861705711 5.15109801814716e-15 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-3065-5p CDK6 -2.74629919868982 1.86846589298284e-08 0.774202349805119 0.064787030605636 mirMAP -0.118059295420914 0.0185164517615316 NA NA NA hsa-miR-30b-5p CDK6 -0.80082237491271 0.000133601914525417 0.774202349805119 0.064787030605636 mirMAP -0.540189292799148 1.61932566833175e-08 NA NA NA hsa-miR-30c-5p CDK6 -0.778774633107998 0.000285599212429142 0.774202349805119 0.064787030605636 mirMAP -0.727075100437403 2.31302505595533e-15 NA NA NA hsa-miR-30d-3p CDK6 -0.977747550180601 4.3048212205381e-05 0.774202349805119 0.064787030605636 mirMAP -0.561334088800932 1.30656981501796e-11 NA NA NA hsa-miR-30d-5p CDK6 -0.675423997639575 0.00270618816039799 0.774202349805119 0.064787030605636 mirMAP -0.785477623920694 1.19356262091604e-19 NA NA NA hsa-miR-30e-3p CDK6 0.215663037684514 0.235375122783534 0.774202349805119 0.064787030605636 mirMAP -0.686700064203411 6.84849442105303e-10 NA NA NA hsa-miR-30e-5p CDK6 -1.23904909539662 1.35561917122176e-09 0.774202349805119 0.064787030605636 mirMAP -0.817058326987529 5.2385475320723e-18 NA NA NA hsa-miR-32-3p CDK6 -2.02436999565685 5.94091197945307e-09 0.774202349805119 0.064787030605636 mirMAP -0.249929478125797 0.000125097299153361 NA NA NA hsa-miR-32-5p CDK6 -2.34056473219422 6.24134585974394e-20 0.774202349805119 0.064787030605636 miRNATAP -0.295032649435311 9.55907730341779e-05 NA NA NA hsa-miR-320a CDK6 -0.43816582801708 0.0390159073347149 0.774202349805119 0.064787030605636 PITA;miRNATAP -0.376224025256019 8.78451776886182e-05 NA NA NA hsa-miR-320b CDK6 -1.55692969039548 1.41071034251917e-08 0.774202349805119 0.064787030605636 PITA;miRNATAP -0.1670921083766 0.0221331057182552 NA NA NA hsa-miR-330-3p CDK6 -0.876747334239085 0.000737090160897034 0.774202349805119 0.064787030605636 PITA;mirMAP -0.427895514362065 2.76679372346252e-08 NA NA NA hsa-miR-335-3p CDK6 -3.08791651139852 5.31309869723529e-12 0.774202349805119 0.064787030605636 mirMAP -0.153251191165497 0.000493500059209 NA NA NA hsa-miR-335-5p CDK6 -1.77247705492746 2.22457658872095e-06 0.774202349805119 0.064787030605636 mirMAP -0.166621089394833 0.00183832978506415 NA NA NA hsa-miR-33a-5p CDK6 -3.79671563098419 1.15966309820345e-18 0.774202349805119 0.064787030605636 miRNATAP -0.187324589024782 0.000129271884100387 NA NA NA hsa-miR-34a-3p CDK6 -1.75590866103657 8.02801510630666e-09 0.774202349805119 0.064787030605636 mirMAP -0.376950684687892 1.73963312821001e-07 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-34a-5p CDK6 -1.90163234525649 1.43092834643609e-14 0.774202349805119 0.064787030605636 miRNAWalker2_validate;miRTarBase;miRNATAP -0.519263514540718 3.07288169543583e-11 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-3613-5p CDK6 -2.64358387329263 1.03737530172455e-24 0.774202349805119 0.064787030605636 miRNATAP -0.21181572504448 0.005712534663484 NA NA NA hsa-miR-362-5p CDK6 -1.59303749908759 9.58267590879704e-08 0.774202349805119 0.064787030605636 mirMAP -0.313855526332272 2.37748256302272e-06 NA NA NA hsa-miR-374a-3p CDK6 -0.53330933050494 0.00192918429705169 0.774202349805119 0.064787030605636 mirMAP -0.273738714505887 0.0220682181270635 NA NA NA hsa-miR-378a-3p CDK6 0.109957200008285 0.716188270032668 0.774202349805119 0.064787030605636 mirMAP -0.397192555694478 2.01427891085214e-09 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-421 CDK6 -1.17791565395543 6.78526676976633e-06 0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.178411637766622 0.0211068498205428 NA NA NA hsa-miR-425-5p CDK6 -3.07071373939774 4.02947460586131e-25 0.774202349805119 0.064787030605636 mirMAP -0.484163394229156 1.07269848409271e-14 NA NA NA hsa-miR-429 CDK6 -4.48815175680773 2.44117492218224e-17 0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.337479964584767 4.50509176972113e-22 NA NA NA hsa-miR-450b-5p CDK6 -1.69244418548325 1.68064054148878e-10 0.774202349805119 0.064787030605636 mirMAP -0.201384976718992 0.00743415077141657 NA NA NA hsa-miR-497-5p CDK6 -0.0257087130056273 0.918145413833362 0.774202349805119 0.064787030605636 miRNATAP -0.245332138327252 0.00264647539053154 NA NA NA hsa-miR-500a-5p CDK6 -1.72110365584658 3.0807246212659e-10 0.774202349805119 0.064787030605636 mirMAP -0.232725295393576 0.00140479513304275 NA NA NA hsa-miR-501-3p CDK6 -1.83132758513743 1.10971547702079e-10 0.774202349805119 0.064787030605636 PITA;TargetScan;miRNATAP -0.414303056979818 1.84547250783893e-09 NA NA NA hsa-miR-502-3p CDK6 -1.50560877085049 1.26474897563737e-11 0.774202349805119 0.064787030605636 PITA;miRNATAP -0.4275399463222 1.5008131463888e-06 NA NA NA hsa-miR-590-5p CDK6 -3.18300989862077 2.06813568597899e-26 0.774202349805119 0.064787030605636 mirMAP;miRNATAP -0.201344503599928 0.00209551899019727 NA NA NA hsa-miR-592 CDK6 -1.51765968871077 0.000636335248013205 0.774202349805119 0.064787030605636 mirMAP -0.143284258807414 0.0019385912538056 NA NA NA hsa-miR-660-5p CDK6 -1.82692095272076 1.92040083607196e-13 0.774202349805119 0.064787030605636 mirMAP -0.339962414215247 1.75914031108584e-05 NA NA NA hsa-miR-664a-3p CDK6 -0.634721925861133 0.00520070178640426 0.774202349805119 0.064787030605636 mirMAP -0.700489354678287 6.77094321174664e-16 NA NA NA hsa-miR-671-5p CDK6 -2.97733652243246 1.2114845234474e-23 0.774202349805119 0.064787030605636 PITA;miRNATAP -0.255214929025129 0.000181908946141654 NA NA NA hsa-miR-92a-3p CDK6 -2.06460102658973 1.44784291084791e-19 0.774202349805119 0.064787030605636 miRNATAP -0.240406113182612 0.00492937850760914 NA NA NA hsa-miR-93-5p CDK6 -3.03961860136032 1.11672209617415e-24 0.774202349805119 0.064787030605636 mirMAP -0.467996685199197 1.00999249823312e-13 NA NA NA hsa-miR-125a-5p CHRNB2 -0.599529391575269 0.0102300147180314 -0.8982649980025 0.0265408963906376 mirMAP -0.256012289723383 0.00239632554787754 NA NA NA hsa-miR-145-5p CHRNB2 1.55259331973518 9.97889123247099e-07 -0.8982649980025 0.0265408963906376 MirTarget -0.146508305501938 0.0167035949599276 NA NA NA hsa-miR-146b-5p CHRNB2 -1.75587235896723 1.15724631266667e-07 -0.8982649980025 0.0265408963906376 miRanda -0.146855109909639 0.0119986643359251 NA NA NA hsa-miR-22-5p CHRNB2 -1.88011544159251 1.63978222572252e-16 -0.8982649980025 0.0265408963906376 mirMAP -0.284137280328199 0.00063799354924372 NA NA NA