miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p ABCA1 2.48882002962836 1.99757727374521e-12 -0.708862099711938 0.00276049487849735 MirTarget;miRNATAP -0.124969755499389 7.12769839746892e-05 NA NA NA hsa-miR-106a-5p ABCD2 2.48882002962836 1.99757727374521e-12 -3.0810144381228 6.24416068964347e-11 MirTarget -0.352425666639332 2.67214951333216e-08 NA NA NA hsa-miR-106a-5p ADAM19 2.48882002962836 1.99757727374521e-12 -1.06497039316686 0.0189522972551201 mirMAP -0.329021671066264 3.62015725834293e-08 NA NA NA hsa-miR-106a-5p ADARB1 2.48882002962836 1.99757727374521e-12 -1.92780468757935 3.75403498492562e-10 MirTarget -0.281866873094979 5.37562026819142e-12 NA NA NA hsa-miR-106a-5p ADCY9 2.48882002962836 1.99757727374521e-12 -1.49969795166377 5.91319152843764e-09 mirMAP -0.206183446129872 1.92301120398209e-09 NA NA NA hsa-miR-106a-5p AHNAK 2.48882002962836 1.99757727374521e-12 -1.65511086697194 9.68769934496862e-10 miRNATAP -0.313141350885747 6.64284522505254e-19 NA NA NA hsa-miR-106a-5p AKAP13 2.48882002962836 1.99757727374521e-12 -1.14731602724292 2.3511548631978e-13 MirTarget;mirMAP;miRNATAP -0.167595031039486 5.71204687352047e-16 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106a-5p ALPK3 2.48882002962836 1.99757727374521e-12 -1.02481976235543 0.000493878363013624 mirMAP -0.129873829750598 0.000946790979847646 NA NA NA hsa-miR-106a-5p ANK2 2.48882002962836 1.99757727374521e-12 -4.31721795702785 2.30783903904989e-14 MirTarget;miRNATAP -0.381765952901347 7.22212168478783e-07 NA NA NA hsa-miR-106a-5p ANKH 2.48882002962836 1.99757727374521e-12 -0.383033248037803 0.21653677802021 MirTarget -0.169471535506453 3.56282645897841e-05 NA NA NA hsa-miR-106a-5p ANKRD29 2.48882002962836 1.99757727374521e-12 -3.46821201627376 7.87727860045694e-10 MirTarget -0.514660201748353 6.51514352598702e-12 NA NA NA hsa-miR-106a-5p ANKRD50 2.48882002962836 1.99757727374521e-12 -0.879415415053786 0.00173665080618598 MirTarget;miRNATAP -0.106035035867292 0.00470308770954508 NA NA NA hsa-miR-106a-5p ANXA11 2.48882002962836 1.99757727374521e-12 -0.425275101208253 0.0184935282594289 mirMAP -0.11853916611015 6.21787068950303e-07 NA NA NA hsa-miR-106a-5p APBB2 2.48882002962836 1.99757727374521e-12 -0.590550070945143 0.00139703077075369 MirTarget;miRNATAP -0.1545011617341 1.69096354869501e-10 NA NA NA hsa-miR-106a-5p APP 2.48882002962836 1.99757727374521e-12 -0.400687156011365 0.0428770191036906 miRNAWalker2_validate;miRTarBase;miRNATAP -0.135834343562215 1.78443700480718e-07 NA NA NA hsa-miR-106a-5p ARHGAP1 2.48882002962836 1.99757727374521e-12 -0.882266671503522 1.75389981751782e-09 MirTarget;miRNATAP -0.167208918069738 1.64992455620957e-18 NA NA NA hsa-miR-106a-5p ARHGAP24 2.48882002962836 1.99757727374521e-12 -2.02152097141819 3.81745641239796e-10 MirTarget -0.329053667155069 1.0999452155444e-14 NA NA NA hsa-miR-106a-5p ARHGEF3 2.48882002962836 1.99757727374521e-12 -0.764795563081465 2.81227805578292e-06 MirTarget;miRNATAP -0.115526061524724 9.60811037738197e-08 NA NA NA hsa-miR-106a-5p ARL10 2.48882002962836 1.99757727374521e-12 -1.12227531152641 0.00197533796722557 mirMAP -0.204438848549523 2.21107208835886e-05 NA NA NA hsa-miR-106a-5p ARL4C 2.48882002962836 1.99757727374521e-12 -0.28406295826987 0.335346460301793 MirTarget;miRNATAP -0.215918252531363 2.33095579611078e-08 NA NA NA hsa-miR-106a-5p ARL9 2.48882002962836 1.99757727374521e-12 -0.118391651947467 0.798250493159071 miRNAWalker2_validate -0.130398780929007 0.0345475505246565 NA NA NA hsa-miR-106a-5p ARSB 2.48882002962836 1.99757727374521e-12 -0.577195231443578 0.000523258390539808 mirMAP -0.153405422118871 1.45769588190543e-12 NA NA NA hsa-miR-106a-5p ASPA 2.48882002962836 1.99757727374521e-12 -4.7558815937205 3.44505820704593e-17 mirMAP -0.256761734495061 0.00100021793026491 NA NA NA hsa-miR-106a-5p ATE1 2.48882002962836 1.99757727374521e-12 -1.08588499225057 2.80031137018061e-05 MirTarget -0.109288342913005 0.0016567343512708 NA NA NA hsa-miR-106a-5p ATP1A2 2.48882002962836 1.99757727374521e-12 -6.96102449322155 1.04173487274373e-23 MirTarget -0.79988702684013 1.94922429973143e-17 NA NA NA hsa-miR-106a-5p ATXN1 2.48882002962836 1.99757727374521e-12 -1.5104377454496 2.95939614593378e-08 miRNATAP -0.276262757235347 1.08918221153455e-14 NA NA NA hsa-miR-106a-5p B3GALT2 2.48882002962836 1.99757727374521e-12 -3.84604037829856 1.89655121428075e-21 MirTarget -0.284400496704001 3.89805312331258e-07 NA NA NA hsa-miR-106a-5p BCL2L2 2.48882002962836 1.99757727374521e-12 -1.26677315930351 4.33863183081921e-14 miRNATAP -0.101518326929789 8.77223601875751e-06 NA NA NA hsa-miR-106a-5p BMP2 2.48882002962836 1.99757727374521e-12 -1.4585556992146 0.00276269620457527 miRNATAP -0.13733219575815 0.0353378641266495 NA NA NA hsa-miR-106a-5p BMP7 2.48882002962836 1.99757727374521e-12 -1.77720755920917 0.028758021459053 mirMAP -0.213107626919806 0.0497769925486375 NA NA NA hsa-miR-106a-5p BMPR2 2.48882002962836 1.99757727374521e-12 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.13439006659681 4.71463912179543e-13 NA NA NA hsa-miR-106a-5p BNC2 2.48882002962836 1.99757727374521e-12 -2.95176911794991 3.46014802400024e-09 miRNATAP -0.601297199598067 1.63545444154074e-20 NA NA NA hsa-miR-106a-5p C14orf28 2.48882002962836 1.99757727374521e-12 -0.8916346148477 2.82928733173783e-09 miRNATAP -0.111820527178359 2.3319503608818e-08 NA NA NA hsa-miR-106a-5p C3orf70 2.48882002962836 1.99757727374521e-12 -2.59753933038565 1.30307841273813e-11 miRNATAP -0.115280822905465 0.0280647114037591 NA NA NA hsa-miR-106a-5p CALD1 2.48882002962836 1.99757727374521e-12 -2.4663455628847 1.26294093745705e-11 miRNATAP -0.494466940496305 4.44678639786279e-26 NA NA NA hsa-miR-106a-5p CBX7 2.48882002962836 1.99757727374521e-12 -2.55289189625386 1.59674659686171e-25 mirMAP -0.216503323445352 1.73680233734099e-10 NA NA NA hsa-miR-106a-5p CCBE1 2.48882002962836 1.99757727374521e-12 -1.0674561145857 0.0959193183860353 mirMAP -0.190747828329542 0.0257290586375793 NA NA NA hsa-miR-106a-5p CCND1 2.48882002962836 1.99757727374521e-12 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.278915751904438 2.46069960202024e-07 NA NA NA hsa-miR-106a-5p CCND2 2.48882002962836 1.99757727374521e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.460265785003224 1.90572227650597e-20 NA NA NA hsa-miR-106a-5p CD69 2.48882002962836 1.99757727374521e-12 -2.49390839555831 5.16539905545377e-07 miRNATAP -0.351587886686173 1.10419981725529e-07 NA NA NA hsa-miR-106a-5p CDK6 2.48882002962836 1.99757727374521e-12 -0.774202349805119 0.064787030605636 mirMAP -0.23817017599031 1.76828696872453e-05 NA NA NA hsa-miR-106a-5p CDKN1A 2.48882002962836 1.99757727374521e-12 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.128693729012364 0.000550088861161385 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106a-5p CELF2 2.48882002962836 1.99757727374521e-12 -3.04719737979328 4.72041352009215e-15 miRNATAP -0.476314229796969 1.31962645133235e-20 NA NA NA hsa-miR-106a-5p CERCAM 2.48882002962836 1.99757727374521e-12 0.212598309982104 0.509677909105679 MirTarget -0.144373714056327 0.000735342870541469 NA NA NA hsa-miR-106a-5p CERK 2.48882002962836 1.99757727374521e-12 -1.13902485711263 9.05019520624814e-05 mirMAP -0.146100494530753 0.000170036299105111 NA NA NA hsa-miR-106a-5p CFL2 2.48882002962836 1.99757727374521e-12 -2.61712932503392 6.6876672984936e-21 MirTarget;miRNATAP -0.288218257983481 2.79342479942035e-14 NA NA NA hsa-miR-106a-5p CHD5 2.48882002962836 1.99757727374521e-12 -3.45897408462801 3.67143157843804e-15 MirTarget;miRNATAP -0.179053275665512 0.00311572741036892 NA NA NA hsa-miR-106a-5p CHD9 2.48882002962836 1.99757727374521e-12 -0.801892369807601 9.04166624968584e-06 MirTarget;miRNATAP -0.110550634289564 4.28998993391456e-06 NA NA NA hsa-miR-106a-5p CLDN16 2.48882002962836 1.99757727374521e-12 0.261976579366797 0.609293772884542 mirMAP -0.136644849977493 0.0454596792534738 NA NA NA hsa-miR-106a-5p CLIP4 2.48882002962836 1.99757727374521e-12 -1.61049215669349 1.71285040007646e-06 MirTarget -0.303318076190087 7.60575101107923e-12 NA NA NA hsa-miR-106a-5p CNR2 2.48882002962836 1.99757727374521e-12 -2.04810214859205 6.16820083171693e-05 mirMAP -0.315661492582085 3.51370332110241e-06 NA NA NA hsa-miR-106a-5p COL1A1 2.48882002962836 1.99757727374521e-12 -0.110889675073027 0.820072046630299 mirMAP -0.435796609970468 5.9115479947617e-12 NA NA NA hsa-miR-106a-5p COL8A2 2.48882002962836 1.99757727374521e-12 -1.27039967006167 0.00295078611440585 mirMAP -0.442195274961458 1.21230235770643e-15 NA NA NA hsa-miR-106a-5p CORO2B 2.48882002962836 1.99757727374521e-12 -2.02918310395295 2.78730592488677e-06 MirTarget;miRNATAP -0.197248113850974 0.00069860810400285 NA NA NA hsa-miR-106a-5p CPEB3 2.48882002962836 1.99757727374521e-12 -1.29730351097465 1.42439515101264e-11 miRNATAP -0.123909878493641 1.77932854714621e-06 NA NA NA hsa-miR-106a-5p CPEB4 2.48882002962836 1.99757727374521e-12 -1.5612678794228 1.72557073170333e-13 mirMAP -0.168238745444551 3.92446182857358e-09 NA NA NA hsa-miR-106a-5p CPT1A 2.48882002962836 1.99757727374521e-12 -0.825914268139749 0.000931222715881622 mirMAP -0.103077354278301 0.00197193889429338 NA NA NA hsa-miR-106a-5p CREB5 2.48882002962836 1.99757727374521e-12 -2.27679484644664 4.56595042875634e-09 MirTarget;miRNATAP -0.27659041406423 1.06737039047926e-07 NA NA NA hsa-miR-106a-5p CRIM1 2.48882002962836 1.99757727374521e-12 -0.446663724501645 0.0534037663554592 MirTarget;miRNATAP -0.107889526344469 0.000438075808434405 NA NA NA hsa-miR-106a-5p CRY2 2.48882002962836 1.99757727374521e-12 -1.68350116294318 3.19934219920631e-30 MirTarget;miRNATAP -0.142485339956635 4.20807738120521e-12 NA NA NA hsa-miR-106a-5p CRYBG3 2.48882002962836 1.99757727374521e-12 -1.11000638076797 4.51084274052305e-05 MirTarget;miRNATAP -0.21502049921908 2.10430298972949e-09 NA NA NA hsa-miR-106a-5p CSF1 2.48882002962836 1.99757727374521e-12 -1.29812834960066 0.000329197071112557 miRNATAP -0.292080056920012 8.20083201848244e-10 NA NA NA hsa-miR-106a-5p CSGALNACT1 2.48882002962836 1.99757727374521e-12 -2.42168335195105 1.21183725562684e-20 MirTarget -0.237966438787617 2.12332874648329e-11 NA NA NA hsa-miR-106a-5p CTSK 2.48882002962836 1.99757727374521e-12 -1.41209514487679 0.000808186129376276 MirTarget -0.45586668267933 5.16455588336559e-17 NA NA NA hsa-miR-106a-5p CXorf36 2.48882002962836 1.99757727374521e-12 -1.52026113089193 1.97066625361571e-09 mirMAP -0.182271349493479 7.88733202938399e-08 NA NA NA hsa-miR-106a-5p CYBRD1 2.48882002962836 1.99757727374521e-12 -2.5547851640342 5.83608437436085e-12 MirTarget -0.407180189882089 8.60259785536857e-17 NA NA NA hsa-miR-106a-5p CYP19A1 2.48882002962836 1.99757727374521e-12 -1.80601668497668 3.00243016481922e-05 miRNAWalker2_validate -0.266187366966017 3.89622503587446e-06 NA NA NA hsa-miR-106a-5p DAB2 2.48882002962836 1.99757727374521e-12 -0.691299391910039 0.0326535251444597 MirTarget;miRNATAP -0.129672192096929 0.00261308308798802 NA NA NA hsa-miR-106a-5p DCBLD2 2.48882002962836 1.99757727374521e-12 -0.127512036942836 0.735967995495379 miRNAWalker2_validate;MirTarget;miRNATAP -0.108771937006602 0.0307651806139807 NA NA NA hsa-miR-106a-5p DIXDC1 2.48882002962836 1.99757727374521e-12 -3.01066558370526 1.36952954348107e-19 mirMAP -0.38751997946375 3.30939938572596e-18 NA NA NA hsa-miR-106a-5p DLG2 2.48882002962836 1.99757727374521e-12 -3.79723748090986 3.01897311382045e-14 mirMAP -0.365570686891079 7.18661376536419e-08 NA NA NA hsa-miR-106a-5p DMD 2.48882002962836 1.99757727374521e-12 -3.69368719337714 3.87883942927561e-15 mirMAP -0.448777406612314 1.21223996104289e-12 NA NA NA hsa-miR-106a-5p DNAJB9 2.48882002962836 1.99757727374521e-12 -0.441226884420603 0.0023917769153801 miRNATAP -0.109973192072212 7.91327283234902e-09 NA NA NA hsa-miR-106a-5p DPYD 2.48882002962836 1.99757727374521e-12 -1.70592656402028 0.000275323430264718 MirTarget -0.472568748283493 8.83004782841325e-15 NA NA NA hsa-miR-106a-5p DPYSL2 2.48882002962836 1.99757727374521e-12 -1.76435544537318 3.16983700434577e-10 MirTarget;miRNATAP -0.24059202636166 1.23704041061385e-10 NA NA NA hsa-miR-106a-5p DST 2.48882002962836 1.99757727374521e-12 -1.11542714896545 9.14769438027749e-05 mirMAP -0.202238442762636 8.45798188267172e-08 NA NA NA hsa-miR-106a-5p DUSP8 2.48882002962836 1.99757727374521e-12 -2.17002902781112 4.33786956113647e-11 MirTarget;miRNATAP -0.171366168804113 0.000125708868957992 NA NA NA hsa-miR-106a-5p EDA2R 2.48882002962836 1.99757727374521e-12 -1.49661459960416 0.00020989877769247 MirTarget -0.24359522182805 5.71430051401982e-06 NA NA NA hsa-miR-106a-5p EGR2 2.48882002962836 1.99757727374521e-12 -2.81415398238775 4.48213127682575e-11 MirTarget;miRNATAP -0.352028165802141 7.69085305498296e-10 NA NA NA hsa-miR-106a-5p EIF5A2 2.48882002962836 1.99757727374521e-12 -1.11920105116458 0.00497256140729196 miRNATAP -0.278439679146185 1.18486015199757e-07 NA NA NA hsa-miR-106a-5p ELK3 2.48882002962836 1.99757727374521e-12 -0.31361161770499 0.256409444995651 MirTarget;miRNATAP -0.184386253012932 3.9181781885102e-07 NA NA NA hsa-miR-106a-5p ENPP1 2.48882002962836 1.99757727374521e-12 -2.09860918748668 4.30690633215035e-06 mirMAP -0.34326454371531 1.46314465098947e-08 NA NA NA hsa-miR-106a-5p ENTPD1 2.48882002962836 1.99757727374521e-12 -1.12219223948292 8.05257550730918e-10 mirMAP -0.215474702237419 1.0245631917905e-19 NA NA NA hsa-miR-106a-5p EPAS1 2.48882002962836 1.99757727374521e-12 -0.531851243328114 0.0280508916176539 miRNATAP -0.179329854810351 1.69031093246451e-08 NA NA NA hsa-miR-106a-5p EPHA7 2.48882002962836 1.99757727374521e-12 -4.20206952913252 6.81894380739864e-12 miRNATAP -0.270020120207681 0.00123316514859204 NA NA NA hsa-miR-106a-5p ETV1 2.48882002962836 1.99757727374521e-12 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.260425779908911 2.72817275994871e-09 NA NA NA hsa-miR-106a-5p F3 2.48882002962836 1.99757727374521e-12 -1.92612930805695 0.000148150348095098 MirTarget;miRNATAP -0.38007411133706 1.47481574432474e-08 NA NA NA hsa-miR-106a-5p FAM46C 2.48882002962836 1.99757727374521e-12 -1.66367766872796 7.82547314993614e-08 MirTarget;miRNATAP -0.149914596678629 0.000327774630785855 NA NA NA hsa-miR-106a-5p FAS 2.48882002962836 1.99757727374521e-12 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate;miRTarBase -0.286433262215431 2.93487884151059e-11 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-106a-5p FAT2 2.48882002962836 1.99757727374521e-12 0.772844115717647 0.309221219592821 MirTarget;miRNATAP -0.289702130850999 0.00416237069313376 NA NA NA hsa-miR-106a-5p FAT4 2.48882002962836 1.99757727374521e-12 -2.56665423966553 1.33682061275506e-12 MirTarget;miRNATAP -0.417938195711757 1.57767352980543e-18 NA NA NA hsa-miR-106a-5p FBXO31 2.48882002962836 1.99757727374521e-12 -0.840161845496367 4.05082277139041e-11 MirTarget -0.12016957878854 9.55174154803725e-13 NA NA NA hsa-miR-106a-5p FGD5 2.48882002962836 1.99757727374521e-12 -1.17343655533674 0.00053495053566632 MirTarget;miRNATAP -0.211930175414967 2.44302491892072e-06 NA NA NA hsa-miR-106a-5p FGFR1 2.48882002962836 1.99757727374521e-12 -2.87837421637657 3.11921581471297e-13 mirMAP -0.384049482399962 3.23721514703937e-13 NA NA NA hsa-miR-106a-5p FGL2 2.48882002962836 1.99757727374521e-12 -3.72258849197433 2.72647514344002e-17 MirTarget -0.503354812060759 9.90632928845194e-18 NA NA NA hsa-miR-106a-5p FHL2 2.48882002962836 1.99757727374521e-12 -0.44824547776978 0.130742692359683 mirMAP -0.156454277376996 6.78185075274693e-05 NA NA NA hsa-miR-106a-5p FIBIN 2.48882002962836 1.99757727374521e-12 -1.93483415962078 0.00101674691327545 MirTarget -0.623266842021643 2.62364923613591e-16 NA NA NA hsa-miR-106a-5p FKBP5 2.48882002962836 1.99757727374521e-12 -1.54368679613987 4.05564573895986e-05 mirMAP -0.157210319588472 0.00182405824577679 NA NA NA hsa-miR-106a-5p FMN1 2.48882002962836 1.99757727374521e-12 -0.369412752960832 0.481903783875014 mirMAP -0.160739560952402 0.0215862545273079 NA NA NA hsa-miR-106a-5p FNDC3A 2.48882002962836 1.99757727374521e-12 -0.53609360792002 0.00476535420494177 MirTarget;miRNATAP -0.11556294898058 4.20506676132404e-06 NA NA NA hsa-miR-106a-5p FOXN3 2.48882002962836 1.99757727374521e-12 -1.43525991184281 2.70084540955391e-16 miRNATAP -0.108075171829608 6.71108336350832e-06 NA NA NA hsa-miR-106a-5p FRMD6 2.48882002962836 1.99757727374521e-12 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.263725976257686 1.5068180586475e-11 NA NA NA hsa-miR-106a-5p FYCO1 2.48882002962836 1.99757727374521e-12 -1.6226100593392 1.01871130782658e-16 MirTarget -0.187906109472682 9.41387942191463e-13 NA NA NA hsa-miR-106a-5p FYN 2.48882002962836 1.99757727374521e-12 -1.46508592139092 9.74677213788621e-08 miRNATAP -0.136134722322941 0.000233160780399328 NA NA NA hsa-miR-106a-5p GAS7 2.48882002962836 1.99757727374521e-12 -2.67478964713793 6.70176551418169e-10 mirMAP -0.48687082991781 8.6310815356768e-18 NA NA NA hsa-miR-106a-5p GBP4 2.48882002962836 1.99757727374521e-12 0.373973157873511 0.30929862371386 mirMAP -0.104594214573935 0.0328277680612224 NA NA NA hsa-miR-106a-5p GFRA1 2.48882002962836 1.99757727374521e-12 -4.99535302188274 6.14065741522982e-16 mirMAP -0.448230923041974 1.05508183911061e-07 NA NA NA hsa-miR-106a-5p GLIS3 2.48882002962836 1.99757727374521e-12 -0.78878644266897 0.0245942929492481 miRNATAP -0.201710633678762 1.42117592792788e-05 NA NA NA hsa-miR-106a-5p GM2A 2.48882002962836 1.99757727374521e-12 0.0744034429919926 0.727891079309959 mirMAP -0.117414679109441 3.18605088779788e-05 NA NA NA hsa-miR-106a-5p GPRC5A 2.48882002962836 1.99757727374521e-12 -1.03883992728525 0.0190871949690872 mirMAP -0.195263200186222 0.000934131937804882 NA NA NA hsa-miR-106a-5p GREM2 2.48882002962836 1.99757727374521e-12 -4.9852150121131 1.5808751237327e-14 mirMAP -0.44351354739807 5.26293216886364e-07 NA NA NA hsa-miR-106a-5p GRM6 2.48882002962836 1.99757727374521e-12 -0.776704428035983 0.147383225966703 mirMAP -0.148447367812923 0.0378963770889192 NA NA NA hsa-miR-106a-5p HABP4 2.48882002962836 1.99757727374521e-12 -1.39704294290047 2.66187560985628e-10 MirTarget;miRNATAP -0.13171253120175 1.01943332680416e-05 NA NA NA hsa-miR-106a-5p HAS2 2.48882002962836 1.99757727374521e-12 -1.4533402537015 0.0063112329586836 MirTarget -0.259822574326777 0.00024371746248153 NA NA NA hsa-miR-106a-5p HDAC4 2.48882002962836 1.99757727374521e-12 -1.80036091395253 1.96398022917234e-18 mirMAP;miRNATAP -0.136570591440433 1.35326617253378e-06 NA NA NA hsa-miR-106a-5p HEG1 2.48882002962836 1.99757727374521e-12 -0.946693018634287 0.00135394650410446 miRNATAP -0.309518744384864 5.14094271988015e-16 NA NA NA hsa-miR-106a-5p HES2 2.48882002962836 1.99757727374521e-12 3.15368028997964 1.36111732082313e-05 mirMAP -0.227046446309642 0.0200209144674069 NA NA NA hsa-miR-106a-5p HFE 2.48882002962836 1.99757727374521e-12 0.0424608745756037 0.891910607894825 mirMAP -0.145818264079156 0.000428668540815032 NA NA NA hsa-miR-106a-5p HIPK3 2.48882002962836 1.99757727374521e-12 -1.74508965708072 2.92750932105647e-06 miRNAWalker2_validate;miRTarBase -0.164854347182113 0.00101285608892979 NA NA NA hsa-miR-106a-5p HLF 2.48882002962836 1.99757727374521e-12 -5.48181644757567 4.24267397704754e-28 MirTarget;miRNATAP -0.486248726712276 2.42491562667657e-12 NA NA NA hsa-miR-106a-5p IGSF10 2.48882002962836 1.99757727374521e-12 -5.30237641574688 9.03000767899905e-16 MirTarget -0.351849553829048 0.000104269488480296 NA NA NA hsa-miR-106a-5p IL10 2.48882002962836 1.99757727374521e-12 -0.985935191660191 0.030813458249972 miRNAWalker2_validate -0.290478145256164 1.46087579355316e-06 NA NA NA hsa-miR-106a-5p IL1RAP 2.48882002962836 1.99757727374521e-12 0.687376288697117 0.0561773808581464 MirTarget -0.184285524641675 0.000113235346123953 NA NA NA hsa-miR-106a-5p IL6R 2.48882002962836 1.99757727374521e-12 -1.86576803083567 2.67166891084766e-06 mirMAP -0.189044848105555 0.000396201599215425 NA NA NA hsa-miR-106a-5p ISM1 2.48882002962836 1.99757727374521e-12 -0.18321158536008 0.672681334519148 miRNATAP -0.276862410269698 1.2534380996764e-06 NA NA NA hsa-miR-106a-5p ITPRIPL2 2.48882002962836 1.99757727374521e-12 -0.0504470383987563 0.792082077987489 MirTarget;miRNATAP -0.12012705980834 1.81091178154095e-06 NA NA NA hsa-miR-106a-5p JAK1 2.48882002962836 1.99757727374521e-12 -0.647144039203939 3.25551149817466e-06 MirTarget -0.133261991596329 2.08270266659009e-13 NA NA NA hsa-miR-106a-5p JAM2 2.48882002962836 1.99757727374521e-12 -3.23918299397816 8.35180981117101e-16 miRNATAP -0.435157922800851 5.35688484225197e-16 NA NA NA hsa-miR-106a-5p JAZF1 2.48882002962836 1.99757727374521e-12 -1.91995536790338 5.72076669427973e-12 MirTarget;miRNATAP -0.295503419660473 1.04701912222979e-15 NA NA NA hsa-miR-106a-5p KATNAL1 2.48882002962836 1.99757727374521e-12 -1.57600243048234 8.15704001509067e-06 MirTarget -0.209324880094619 9.0942284676738e-06 NA NA NA hsa-miR-106a-5p KBTBD8 2.48882002962836 1.99757727374521e-12 -1.48076576822805 3.48452044602148e-06 MirTarget -0.168499968055309 8.09312603462564e-05 NA NA NA hsa-miR-106a-5p KCND3 2.48882002962836 1.99757727374521e-12 -4.09076879902846 8.99024124525251e-13 mirMAP -0.601416180005295 2.39369437109937e-15 NA NA NA hsa-miR-106a-5p KCNMA1 2.48882002962836 1.99757727374521e-12 -3.7780119035139 4.92766955950165e-16 miRNATAP -0.516602806661483 8.42540584449176e-17 NA NA NA hsa-miR-106a-5p KIAA0513 2.48882002962836 1.99757727374521e-12 -1.86789576149102 3.75602674217217e-12 MirTarget;miRNATAP -0.330331162217967 4.32558407231132e-21 NA NA NA hsa-miR-106a-5p KIAA0922 2.48882002962836 1.99757727374521e-12 -1.15666545502932 0.000128930697622669 MirTarget -0.219662461828648 3.85154199491293e-08 NA NA NA hsa-miR-106a-5p KIF13A 2.48882002962836 1.99757727374521e-12 -1.2222279491778 3.03312683064576e-07 miRNATAP -0.149728782253139 2.70814402530705e-06 NA NA NA hsa-miR-106a-5p KIF26B 2.48882002962836 1.99757727374521e-12 2.2621717521007 2.79501706169276e-08 miRNATAP -0.188831691627227 0.000596197955727867 NA NA NA hsa-miR-106a-5p KLF13 2.48882002962836 1.99757727374521e-12 -1.16141618366409 1.36372480238947e-05 mirMAP -0.125857733052702 0.00043333903136958 NA NA NA hsa-miR-106a-5p KLF9 2.48882002962836 1.99757727374521e-12 -2.78806270116525 1.14874620908535e-18 MirTarget;miRNATAP -0.366192939473656 4.47770295843019e-18 NA NA NA hsa-miR-106a-5p KLHL21 2.48882002962836 1.99757727374521e-12 -1.03680560428652 2.27490455113544e-07 mirMAP -0.144796992252294 5.61769610842119e-08 NA NA NA hsa-miR-106a-5p KPNA3 2.48882002962836 1.99757727374521e-12 -0.573359539342796 0.00262291748998806 MirTarget;miRNATAP -0.138085214897214 3.68079376048879e-08 NA NA NA hsa-miR-106a-5p LAT2 2.48882002962836 1.99757727374521e-12 -0.572864831090151 0.0895503459129469 mirMAP -0.212598017979001 1.79276311541849e-06 NA NA NA hsa-miR-106a-5p LDB3 2.48882002962836 1.99757727374521e-12 -3.78725573134894 2.18182402606317e-20 mirMAP -0.373312440073296 2.53610644521501e-11 NA NA NA hsa-miR-106a-5p LDLR 2.48882002962836 1.99757727374521e-12 -1.42287698144687 6.72139144904192e-05 miRNATAP -0.149485136972215 0.00177624719125313 NA NA NA hsa-miR-106a-5p LHX6 2.48882002962836 1.99757727374521e-12 -0.886870795693206 0.00203651922651584 MirTarget;miRNATAP -0.115946964684884 0.00251708542889393 NA NA NA hsa-miR-106a-5p LIF 2.48882002962836 1.99757727374521e-12 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.182501818937697 0.000538078759637783 NA NA NA hsa-miR-106a-5p LIMA1 2.48882002962836 1.99757727374521e-12 -0.0980561564780018 0.686117371580378 MirTarget;miRNATAP -0.14991062419947 2.71046775860758e-06 NA NA NA hsa-miR-106a-5p LMO3 2.48882002962836 1.99757727374521e-12 -4.72180755919393 2.71125773614461e-13 MirTarget;miRNATAP -0.415196916358481 2.3025412812228e-06 NA NA NA hsa-miR-106a-5p LPP 2.48882002962836 1.99757727374521e-12 -2.04092311415528 2.98839088727532e-15 mirMAP -0.256417361280704 1.37130489005798e-13 NA NA NA hsa-miR-106a-5p LRIG1 2.48882002962836 1.99757727374521e-12 -1.87053716003213 1.21172145271197e-05 MirTarget -0.384566949108436 7.54662360075181e-12 NA NA NA hsa-miR-106a-5p LRRK1 2.48882002962836 1.99757727374521e-12 -0.583871959086947 0.0135987759434247 miRNATAP -0.104863279242388 0.000860892236799052 NA NA NA hsa-miR-106a-5p LRRN4CL 2.48882002962836 1.99757727374521e-12 -3.42892953262668 1.80396841915527e-16 mirMAP -0.46160028330659 9.69699398653576e-17 NA NA NA hsa-miR-106a-5p MAF 2.48882002962836 1.99757727374521e-12 -1.28341922239874 0.00015825213662883 mirMAP -0.304503594528847 7.73225570090961e-12 NA NA NA hsa-miR-106a-5p MAP1B 2.48882002962836 1.99757727374521e-12 -3.18358434812783 4.83606017602339e-16 mirMAP -0.417989032491687 1.58279773004773e-15 NA NA NA hsa-miR-106a-5p MAPK4 2.48882002962836 1.99757727374521e-12 -3.72102537270416 5.14282599876177e-08 MirTarget;miRNATAP -0.197963362925965 0.0325599015906543 NA NA NA hsa-miR-106a-5p MAPRE2 2.48882002962836 1.99757727374521e-12 -1.48556495228465 7.11230591567608e-09 mirMAP -0.232985328220336 6.97797287646824e-12 NA NA NA hsa-miR-106a-5p MCC 2.48882002962836 1.99757727374521e-12 -1.13976055087047 0.000453102417948938 MirTarget -0.206910403939344 1.58887670227739e-06 NA NA NA hsa-miR-106a-5p MLXIP 2.48882002962836 1.99757727374521e-12 -1.20422349697114 3.43095163442193e-10 MirTarget -0.154308043034832 1.69237788471494e-09 NA NA NA hsa-miR-106a-5p MMP16 2.48882002962836 1.99757727374521e-12 -1.93731176203338 4.78308892783825e-06 mirMAP -0.298993155756224 1.10048447864023e-07 NA NA NA hsa-miR-106a-5p MMP3 2.48882002962836 1.99757727374521e-12 -0.531092454582771 0.500895901120092 MirTarget -0.52002622735815 5.56362659155627e-07 NA NA NA hsa-miR-106a-5p MR1 2.48882002962836 1.99757727374521e-12 0.160187899178531 0.456728268620272 mirMAP -0.101503736925125 0.000367895705665887 NA NA NA hsa-miR-106a-5p MSRB3 2.48882002962836 1.99757727374521e-12 -3.32124931554379 1.17358848755899e-14 mirMAP -0.580583997790724 2.75260317276883e-25 NA NA NA hsa-miR-106a-5p MXRA7 2.48882002962836 1.99757727374521e-12 -1.86234769030151 8.58781238817568e-15 mirMAP -0.283751652715767 3.07233525717824e-19 NA NA NA hsa-miR-106a-5p MYO1C 2.48882002962836 1.99757727374521e-12 -0.543454696594437 0.000472586522610152 mirMAP -0.103356665523797 4.81742216623189e-07 NA NA NA hsa-miR-106a-5p MYO5A 2.48882002962836 1.99757727374521e-12 -0.274576441491861 0.311620335084615 mirMAP -0.155852730522564 1.36327358169278e-05 NA NA NA hsa-miR-106a-5p NACC2 2.48882002962836 1.99757727374521e-12 -1.55788671075335 8.36923407002004e-11 MirTarget -0.194911051738364 1.26324474422961e-09 NA NA NA hsa-miR-106a-5p NBEA 2.48882002962836 1.99757727374521e-12 -3.53497100925373 1.98262703308568e-12 MirTarget;miRNATAP -0.188321341741262 0.00617252623219891 NA NA NA hsa-miR-106a-5p NBL1 2.48882002962836 1.99757727374521e-12 -0.817342180143252 0.00406030424726018 miRNATAP -0.310113903184617 2.28137780012173e-17 NA NA NA hsa-miR-106a-5p NFASC 2.48882002962836 1.99757727374521e-12 -2.95717922837883 4.31475260476481e-14 mirMAP -0.343287000192632 7.51406334207638e-11 NA NA NA hsa-miR-106a-5p NFIA 2.48882002962836 1.99757727374521e-12 -2.09936885926166 1.0458025267903e-15 mirMAP -0.194732907432505 4.60254206854004e-08 NA NA NA hsa-miR-106a-5p NFIC 2.48882002962836 1.99757727374521e-12 -1.57099939804843 8.09399770340134e-09 miRNATAP -0.142491596007409 0.000105339618463142 NA NA NA hsa-miR-106a-5p NOL4 2.48882002962836 1.99757727374521e-12 -3.93667074834125 9.70654898780219e-12 miRNATAP -0.281186738003297 0.000354978044629165 NA NA NA hsa-miR-106a-5p NPAS3 2.48882002962836 1.99757727374521e-12 -2.24907906516082 1.91416491531777e-06 miRNATAP -0.145346187762248 0.0225519751729246 NA NA NA hsa-miR-106a-5p NTN1 2.48882002962836 1.99757727374521e-12 -2.90496349995287 8.65251378142323e-09 mirMAP;miRNATAP -0.352033918039497 1.95056200078408e-07 NA NA NA hsa-miR-106a-5p NTRK3 2.48882002962836 1.99757727374521e-12 -5.17034960965042 5.23662623079398e-21 mirMAP -0.562177832557014 5.56583014007757e-14 NA NA NA hsa-miR-106a-5p NUAK1 2.48882002962836 1.99757727374521e-12 0.329626043944068 0.281541076624495 mirMAP -0.150549644665791 0.000205288487884018 NA NA NA hsa-miR-106a-5p OSBPL5 2.48882002962836 1.99757727374521e-12 -1.04683244934429 7.14704106013132e-08 miRNATAP -0.172174342827907 1.94066374373283e-11 NA NA NA hsa-miR-106a-5p OSR1 2.48882002962836 1.99757727374521e-12 -2.00162314531515 0.000108440750546206 MirTarget;miRNATAP -0.307103797455009 8.20591542284584e-06 NA NA NA hsa-miR-106a-5p OSTM1 2.48882002962836 1.99757727374521e-12 -0.771975269003669 5.13573784724769e-06 MirTarget -0.184250352908441 4.05541415896238e-17 NA NA NA hsa-miR-106a-5p OTUD1 2.48882002962836 1.99757727374521e-12 -0.631011216370557 0.0034630319674558 miRNATAP -0.133417828280487 2.98738052653383e-06 NA NA NA hsa-miR-106a-5p PBX3 2.48882002962836 1.99757727374521e-12 -0.902716925798456 5.32058132065644e-06 miRNATAP -0.111675381399411 2.47566503801632e-05 NA NA NA hsa-miR-106a-5p PCDHA3 2.48882002962836 1.99757727374521e-12 -3.21401478399889 1.16809157611259e-08 MirTarget -0.232792712684265 0.00227618086561246 NA NA NA hsa-miR-106a-5p PCDHA4 2.48882002962836 1.99757727374521e-12 -1.46858668721168 0.0491363344371275 MirTarget -0.346051837803793 0.000487487985559158 NA NA NA hsa-miR-106a-5p PCDHA6 2.48882002962836 1.99757727374521e-12 -0.855343670667666 0.186255397591143 MirTarget;miRNATAP -0.21536108193392 0.0124876880568984 NA NA NA hsa-miR-106a-5p PCDHAC2 2.48882002962836 1.99757727374521e-12 -2.0484555476872 0.000785603669097829 MirTarget -0.171184112262644 0.0364137076305066 NA NA NA hsa-miR-106a-5p PDCD1LG2 2.48882002962836 1.99757727374521e-12 -0.577757086604693 0.287866674080197 MirTarget -0.363554296344234 3.76161823945496e-07 NA NA NA hsa-miR-106a-5p PDE1C 2.48882002962836 1.99757727374521e-12 -4.13701966391324 7.08661414779568e-16 mirMAP -0.449346367328574 9.45608929849859e-11 NA NA NA hsa-miR-106a-5p PDE7B 2.48882002962836 1.99757727374521e-12 -2.36773758312254 1.80893813931467e-10 mirMAP -0.187518219634401 0.000196296458511022 NA NA NA hsa-miR-106a-5p PDGFRA 2.48882002962836 1.99757727374521e-12 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.371298633316283 8.91032038900892e-13 NA NA NA hsa-miR-106a-5p PER2 2.48882002962836 1.99757727374521e-12 -2.130626372587 2.07337121539042e-22 mirMAP -0.165568498766144 4.6101457307738e-08 NA NA NA hsa-miR-106a-5p PGM2L1 2.48882002962836 1.99757727374521e-12 -1.01115316371046 0.000101645754958713 MirTarget -0.155658385844369 6.86502601886214e-06 NA NA NA hsa-miR-106a-5p PGR 2.48882002962836 1.99757727374521e-12 -3.89032806407222 2.9562063209597e-19 mirMAP -0.482460824641772 1.28787582743111e-16 NA NA NA hsa-miR-106a-5p PIP4K2A 2.48882002962836 1.99757727374521e-12 -0.910805543770034 1.94691784002652e-06 MirTarget -0.125029319629996 9.31288950644284e-07 NA NA NA hsa-miR-106a-5p PKD2 2.48882002962836 1.99757727374521e-12 -1.0649370854678 4.24438450658801e-08 MirTarget;miRNATAP -0.147061792615089 1.30294487555491e-08 NA NA NA hsa-miR-106a-5p PLAG1 2.48882002962836 1.99757727374521e-12 0.792820606542612 0.0545582002485086 miRNATAP -0.10837661635133 0.0490514380321286 NA NA NA hsa-miR-106a-5p PLEKHA2 2.48882002962836 1.99757727374521e-12 -0.675620029930307 0.000261262497826845 mirMAP -0.105806008815645 1.67826271522674e-05 NA NA NA hsa-miR-106a-5p PLEKHO2 2.48882002962836 1.99757727374521e-12 -1.31825818505218 6.80048674496995e-11 MirTarget;miRNATAP -0.201305094367838 4.8291289566473e-14 NA NA NA hsa-miR-106a-5p PLSCR4 2.48882002962836 1.99757727374521e-12 -2.11946408050861 2.7227459394389e-09 MirTarget -0.286292196413931 1.73495341404802e-09 NA NA NA hsa-miR-106a-5p PPP1R3B 2.48882002962836 1.99757727374521e-12 -1.55593326644501 2.87370091719163e-10 MirTarget;miRNATAP -0.17843225615625 7.18411884474548e-08 NA NA NA hsa-miR-106a-5p PPP3CA 2.48882002962836 1.99757727374521e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.11191172835948 1.79556273427309e-07 NA NA NA hsa-miR-106a-5p PRDM11 2.48882002962836 1.99757727374521e-12 -1.58779074535457 6.60054140619851e-08 miRNATAP -0.139997769714332 0.000409574741456989 NA NA NA hsa-miR-106a-5p PRELP 2.48882002962836 1.99757727374521e-12 -4.33165618526589 1.8885949692004e-15 mirMAP -0.75131924857931 2.37399917967261e-26 NA NA NA hsa-miR-106a-5p PRR16 2.48882002962836 1.99757727374521e-12 -0.996918284378611 0.00771441104331326 MirTarget;miRNATAP -0.298659500253403 1.17026092744075e-09 NA NA NA hsa-miR-106a-5p PRRX1 2.48882002962836 1.99757727374521e-12 -1.17847539982928 0.0280799671619873 MirTarget;miRNATAP -0.483791671670442 4.41216441065193e-12 NA NA NA hsa-miR-106a-5p PSD 2.48882002962836 1.99757727374521e-12 -4.40751964887383 8.80165532923434e-18 miRNATAP -0.652342328660853 6.40247035803605e-22 NA NA NA hsa-miR-106a-5p PTEN 2.48882002962836 1.99757727374521e-12 -0.452835975443078 0.00142504206837966 miRNATAP -0.119115957971973 1.32932348443908e-10 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-106a-5p PTGER3 2.48882002962836 1.99757727374521e-12 -3.17892614473001 1.0932904794636e-07 miRNATAP -0.441026463497622 3.32006377325527e-08 NA NA NA hsa-miR-106a-5p PTGFRN 2.48882002962836 1.99757727374521e-12 -0.0792318045446621 0.737199669606105 MirTarget;miRNATAP -0.128765120476029 3.63493809060268e-05 NA NA NA hsa-miR-106a-5p PTHLH 2.48882002962836 1.99757727374521e-12 -0.637337427958821 0.359541326845111 MirTarget;miRNATAP -0.549964804518897 1.49826518016467e-09 NA NA NA hsa-miR-106a-5p PTPRD 2.48882002962836 1.99757727374521e-12 -3.62979486144354 1.88740064210481e-09 miRNATAP -0.484522026329402 1.92843699128346e-09 NA NA NA hsa-miR-106a-5p PTRF 2.48882002962836 1.99757727374521e-12 -2.06650690899146 9.81371687209631e-09 mirMAP -0.479026141641318 2.54846859407322e-25 NA NA NA hsa-miR-106a-5p PXDN 2.48882002962836 1.99757727374521e-12 -0.875623848431158 0.0187054169470399 MirTarget -0.334947516713978 5.00665367968585e-12 NA NA NA hsa-miR-106a-5p RAB11FIP5 2.48882002962836 1.99757727374521e-12 -0.275218903695492 0.0980214449037859 MirTarget -0.124846742870565 9.64168962821072e-09 NA NA NA hsa-miR-106a-5p RAB30 2.48882002962836 1.99757727374521e-12 -1.46673818899504 1.29730263099078e-07 mirMAP;miRNATAP -0.162552374005786 1.29057287935501e-05 NA NA NA hsa-miR-106a-5p RARB 2.48882002962836 1.99757727374521e-12 -1.77858429602091 2.28807354868447e-06 miRNATAP -0.287825863268189 8.1547870452918e-09 27342319 The results of dual-luciferase reporter assay demonstrated that miR-106a directly targeted retinoic acid receptor beta RARB 3'-UTR miR-106a-RARB promoted viability of thyroid cancer cells by regulating MEKK2-ERK1/2 and MEKK2-ERK5 pathway thyroid cancer hsa-miR-106a-5p RASD1 2.48882002962836 1.99757727374521e-12 -2.74915412974025 3.99047754259219e-10 MirTarget -0.16930128643301 0.00462224550378028 NA NA NA hsa-miR-106a-5p RASGRF2 2.48882002962836 1.99757727374521e-12 -0.959101466033611 0.00295453490406439 MirTarget -0.253504555445005 2.23776501835649e-09 NA NA NA hsa-miR-106a-5p RB1 2.48882002962836 1.99757727374521e-12 -0.453832349621869 0.0641807656041741 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.207146169416987 9.29749287107945e-11 NA NA NA hsa-miR-106a-5p RBMS2 2.48882002962836 1.99757727374521e-12 -0.473519179174953 0.00699528873663777 miRNATAP -0.117856564276915 3.48994875761029e-07 NA NA NA hsa-miR-106a-5p REV3L 2.48882002962836 1.99757727374521e-12 -1.48371551738225 3.11717527702179e-13 miRNATAP -0.126211388088448 5.0155104611563e-06 NA NA NA hsa-miR-106a-5p RGL1 2.48882002962836 1.99757727374521e-12 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.148018139060164 2.61582240816701e-05 NA NA NA hsa-miR-106a-5p RGMA 2.48882002962836 1.99757727374521e-12 -2.72995858483666 2.24436220047071e-06 miRNATAP -0.394420406827551 2.9197271496676e-07 NA NA NA hsa-miR-106a-5p RHOC 2.48882002962836 1.99757727374521e-12 0.0673095709283142 0.721164432786366 MirTarget;miRNATAP -0.120858109256202 1.08105900492118e-06 NA NA NA hsa-miR-106a-5p RNF145 2.48882002962836 1.99757727374521e-12 -1.13456828501773 4.01788098713681e-06 MirTarget -0.188113211026922 7.88990337676812e-09 NA NA NA hsa-miR-106a-5p RORA 2.48882002962836 1.99757727374521e-12 -1.82057461685128 1.16708465709096e-09 MirTarget;miRNATAP -0.116125649782405 0.00424796161020632 NA NA NA hsa-miR-106a-5p RUNX3 2.48882002962836 1.99757727374521e-12 -0.767357649844932 0.0744824809630773 MirTarget -0.204918501665455 0.000334087662537518 23932924 MicroRNA 106a induces multidrug resistance in gastric cancer by targeting RUNX3; Finally we show that runt-related trans factor 3 RUNX3 is the functional target of miR-106a; Collectively these findings demonstrate that miR-106a may promote MDR in GC cells by targeting RUNX3 drug resistance gastric cancer hsa-miR-106a-5p S1PR1 2.48882002962836 1.99757727374521e-12 -2.02910578971785 1.83864289723775e-12 MirTarget;miRNATAP -0.252902243152504 5.54938678062947e-11 NA NA NA hsa-miR-106a-5p SACS 2.48882002962836 1.99757727374521e-12 -1.4220775069626 0.000112393798402941 MirTarget;miRNATAP -0.209596906910621 1.93790171053271e-05 NA NA NA hsa-miR-106a-5p SCN1B 2.48882002962836 1.99757727374521e-12 -2.06795854735244 3.41501873074008e-08 mirMAP -0.373676073919402 3.24204588433758e-14 NA NA NA hsa-miR-106a-5p SCN2B 2.48882002962836 1.99757727374521e-12 -4.29366513636715 3.96960287530702e-15 MirTarget -0.556230411816619 2.88059262736606e-14 NA NA NA hsa-miR-106a-5p SCN3A 2.48882002962836 1.99757727374521e-12 -2.32699009748223 7.40591172107087e-07 MirTarget -0.224437768250734 0.000384616083609299 NA NA NA hsa-miR-106a-5p SCN3B 2.48882002962836 1.99757727374521e-12 -2.7193581647491 2.37635042987728e-09 mirMAP -0.350527380331033 8.71411793904054e-09 NA NA NA hsa-miR-106a-5p SEC14L5 2.48882002962836 1.99757727374521e-12 -1.9585056768621 1.373499911545e-06 mirMAP -0.136355998626161 0.0126822024246466 NA NA NA hsa-miR-106a-5p SEMA4B 2.48882002962836 1.99757727374521e-12 0.234483728015648 0.444458795766879 MirTarget -0.112977196012277 0.00557270144542282 NA NA NA hsa-miR-106a-5p SERTAD4 2.48882002962836 1.99757727374521e-12 -0.337489872123238 0.459901508912778 mirMAP -0.147438023083927 0.0153022894906346 NA NA NA hsa-miR-106a-5p SETD7 2.48882002962836 1.99757727374521e-12 -1.13463057726458 1.78342966519954e-10 mirMAP -0.140006623032288 3.92574283450973e-09 NA NA NA hsa-miR-106a-5p SGCD 2.48882002962836 1.99757727374521e-12 -3.54960120603853 1.88168939363754e-09 mirMAP -0.710233311073304 1.98394247138796e-20 NA NA NA hsa-miR-106a-5p SGTB 2.48882002962836 1.99757727374521e-12 -0.742273008815391 0.00179777008986928 MirTarget -0.148816257604182 2.27890992415374e-06 NA NA NA hsa-miR-106a-5p SH2B3 2.48882002962836 1.99757727374521e-12 -0.500441864762738 0.0325665390937359 MirTarget -0.129273832024528 3.03497773714611e-05 NA NA NA hsa-miR-106a-5p SH3PXD2A 2.48882002962836 1.99757727374521e-12 -0.987155493438988 1.02406192375196e-05 MirTarget;miRNATAP -0.277064372355949 3.15088530826288e-22 NA NA NA hsa-miR-106a-5p SHROOM4 2.48882002962836 1.99757727374521e-12 -0.916502592130072 0.00190236529835903 mirMAP -0.149725381299285 0.000138013328730846 NA NA NA hsa-miR-106a-5p SIRPA 2.48882002962836 1.99757727374521e-12 -0.55339733363088 0.119266182012343 miRNAWalker2_validate -0.266735784202709 1.03002266329741e-08 NA NA NA hsa-miR-106a-5p SLC16A12 2.48882002962836 1.99757727374521e-12 -0.975164130666574 0.0455225768500397 miRNATAP -0.170649884153128 0.00866883497241907 NA NA NA hsa-miR-106a-5p SLC17A7 2.48882002962836 1.99757727374521e-12 -2.13016790621225 2.75270848395237e-08 miRNATAP -0.183051226820566 0.000403356197325149 NA NA NA hsa-miR-106a-5p SLC2A4 2.48882002962836 1.99757727374521e-12 -5.30758458064026 1.82451434581444e-24 miRNATAP -0.543378242980737 2.49184073612021e-14 NA NA NA hsa-miR-106a-5p SLC39A14 2.48882002962836 1.99757727374521e-12 -0.740419591746377 0.00495509756841203 mirMAP -0.191429259958531 3.43998053194858e-08 NA NA NA hsa-miR-106a-5p SLC40A1 2.48882002962836 1.99757727374521e-12 -1.1544421947842 0.000694845818716436 miRNATAP -0.152240775540991 0.000808744384515428 NA NA NA hsa-miR-106a-5p SLC46A3 2.48882002962836 1.99757727374521e-12 -0.583906818008395 0.0453582675629221 MirTarget -0.254882797105702 2.0136328936165e-11 NA NA NA hsa-miR-106a-5p SLC6A9 2.48882002962836 1.99757727374521e-12 -0.447894573870129 0.140243510464252 miRNATAP -0.240837784082338 1.32832575252157e-09 NA NA NA hsa-miR-106a-5p SLFN5 2.48882002962836 1.99757727374521e-12 -0.756453966970185 0.00885190121251301 mirMAP -0.105279554534277 0.00631799616201818 NA NA NA hsa-miR-106a-5p SLITRK3 2.48882002962836 1.99757727374521e-12 -3.40988534925503 7.10144177290762e-08 miRNATAP -0.535743877649104 1.74504040775624e-10 NA NA NA hsa-miR-106a-5p SLMAP 2.48882002962836 1.99757727374521e-12 -1.93428348280594 2.36632563569771e-23 mirMAP -0.204765819487083 1.06703526884527e-14 NA NA NA hsa-miR-106a-5p SMAD7 2.48882002962836 1.99757727374521e-12 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.125254691617488 2.22681317473832e-05 NA NA NA hsa-miR-106a-5p SMOC2 2.48882002962836 1.99757727374521e-12 -3.77071504008826 1.36024971965293e-14 miRNATAP -0.598817278018039 1.37623918719244e-20 NA NA NA hsa-miR-106a-5p SNTB2 2.48882002962836 1.99757727374521e-12 -0.441658705547666 0.00100504578260347 miRNATAP -0.102368442086093 6.15898585340803e-09 NA NA NA hsa-miR-106a-5p SORBS2 2.48882002962836 1.99757727374521e-12 -3.6862885145227 2.51155368959194e-15 MirTarget -0.341286235067805 7.45017252017138e-08 NA NA NA hsa-miR-106a-5p SPRED1 2.48882002962836 1.99757727374521e-12 -0.64004595524649 0.00626859347930208 miRNATAP -0.182750533660742 2.71440983693664e-09 NA NA NA hsa-miR-106a-5p SRL 2.48882002962836 1.99757727374521e-12 -3.55937223437307 6.92032680913248e-20 mirMAP -0.407695004868536 1.10642309579286e-14 NA NA NA hsa-miR-106a-5p SSFA2 2.48882002962836 1.99757727374521e-12 -0.51178832437508 0.043734278908624 MirTarget;miRNATAP -0.119180669424217 0.000403934095684685 NA NA NA hsa-miR-106a-5p ST6GALNAC3 2.48882002962836 1.99757727374521e-12 -2.04578308207892 3.03442932816697e-11 MirTarget -0.160292718058241 0.000126011503435708 NA NA NA hsa-miR-106a-5p ST6GALNAC6 2.48882002962836 1.99757727374521e-12 -1.23873693525411 1.18711393528757e-12 MirTarget;miRNATAP -0.152630278004927 5.98627118032134e-11 NA NA NA hsa-miR-106a-5p STAT3 2.48882002962836 1.99757727374521e-12 -0.539456513473352 0.0002104451396002 miRNATAP -0.104487317381686 5.1411814156043e-08 27510094;27325313 Furthermore the present study revealed that IL-6 inhibited miR-106a expression by activating STAT3;We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression ; ovarian cancer;breast cancer hsa-miR-106a-5p STC1 2.48882002962836 1.99757727374521e-12 -1.55340441030689 1.29077994156941e-05 miRNATAP -0.171595022935987 0.000323190030682308 NA NA NA hsa-miR-106a-5p STOM 2.48882002962836 1.99757727374521e-12 -1.35582063522137 1.10537651475554e-05 MirTarget -0.317923287677376 2.37340330365831e-15 NA NA NA hsa-miR-106a-5p STX1B 2.48882002962836 1.99757727374521e-12 -0.831193288425681 0.0477395804955152 mirMAP -0.16611946067774 0.0029632578499965 NA NA NA hsa-miR-106a-5p SV2B 2.48882002962836 1.99757727374521e-12 -2.33341367960543 7.07116491599061e-05 MirTarget;mirMAP -0.286113336939964 0.00026978031117907 NA NA NA hsa-miR-106a-5p SYNE1 2.48882002962836 1.99757727374521e-12 -2.74794094238031 2.93341128284671e-19 MirTarget -0.335562484372515 3.89358551703883e-16 NA NA NA hsa-miR-106a-5p TACC1 2.48882002962836 1.99757727374521e-12 -1.71010964840655 3.78195172257726e-09 MirTarget -0.204467520593091 1.45496061060483e-07 NA NA NA hsa-miR-106a-5p TBC1D2 2.48882002962836 1.99757727374521e-12 0.587532097833035 0.0203543554853865 MirTarget -0.140140025489903 2.95491211726826e-05 NA NA NA hsa-miR-106a-5p TCF4 2.48882002962836 1.99757727374521e-12 -1.61270531688003 6.6047419057989e-09 miRNATAP -0.234306657325832 2.30060928611997e-10 NA NA NA hsa-miR-106a-5p TCF7L1 2.48882002962836 1.99757727374521e-12 -1.29563210038614 0.00022110689990566 MirTarget -0.237528555928573 3.23041076064227e-07 NA NA NA hsa-miR-106a-5p TCTEX1D1 2.48882002962836 1.99757727374521e-12 -1.16621598390617 0.000863277810304515 miRNATAP -0.277315826940264 1.71571368443451e-09 NA NA NA hsa-miR-106a-5p TEAD1 2.48882002962836 1.99757727374521e-12 -1.49495998391161 1.96516757915294e-13 mirMAP -0.121407873183656 1.14372413963813e-05 NA NA NA hsa-miR-106a-5p TGFBR2 2.48882002962836 1.99757727374521e-12 -1.5612933795263 2.09571393414153e-11 miRTarBase;miRNATAP -0.174237668172683 2.7024970040951e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106a-5p TGM2 2.48882002962836 1.99757727374521e-12 -1.14690935857596 0.0144751654848477 MirTarget -0.445206110194064 2.71333481227038e-13 NA NA NA hsa-miR-106a-5p THBS2 2.48882002962836 1.99757727374521e-12 -0.819009338080235 0.127001426128545 MirTarget -0.45330116032702 9.62830193644936e-11 NA NA NA hsa-miR-106a-5p THSD4 2.48882002962836 1.99757727374521e-12 -2.37339687749734 3.92006931404185e-13 mirMAP -0.226236901573799 3.33623363243733e-07 NA NA NA hsa-miR-106a-5p TIMP2 2.48882002962836 1.99757727374521e-12 -1.7485334269093 7.3578966378154e-06 miRNATAP -0.410944069879266 5.33415083231498e-16 24444603;24440352;27142596 Furthermore our investigation shows that miR-106a has an oncogenic role in pancreatic tumorigenesis by promoting cancer cell proliferation epithelial-mesenchymal transition and invasion by targeting tissue inhibitors of metalloproteinase 2 TIMP-2;MicroRNA 106a targets TIMP2 to regulate invasion and metastasis of gastric cancer; Moreover we show that TIMP2 is a direct downstream target for miR-106a and knockdown of TIMP2 strengthens the beneficial effects of miR-106a;Moreover expression of TIMP2 was inversely associated with miR-106a in nodule tissues tumorigenesis;metastasis; pancreatic cancer;gastric cancer;gastric cancer hsa-miR-106a-5p TIMP3 2.48882002962836 1.99757727374521e-12 -1.51021603240101 2.67590650148561e-05 miRNATAP -0.355463736964527 3.51559475554685e-14 NA NA NA hsa-miR-106a-5p TP53INP2 2.48882002962836 1.99757727374521e-12 -2.21250190189587 4.52774358230457e-20 MirTarget;miRNATAP -0.15443572702089 3.66830980440959e-06 NA NA NA hsa-miR-106a-5p TRAF3IP2 2.48882002962836 1.99757727374521e-12 -0.0374115785156421 0.841088030781543 mirMAP -0.102564699226007 3.08191764565828e-05 NA NA NA hsa-miR-106a-5p TRAM2 2.48882002962836 1.99757727374521e-12 -0.480560165227073 0.0151980825679313 mirMAP -0.132223641983188 3.98288920914295e-07 NA NA NA hsa-miR-106a-5p TSHZ3 2.48882002962836 1.99757727374521e-12 -2.3826164042391 2.29782206551949e-10 MirTarget;miRNATAP -0.461512809824115 2.94353261042385e-21 NA NA NA hsa-miR-106a-5p TSPAN5 2.48882002962836 1.99757727374521e-12 -0.895367046869303 0.017170907865926 mirMAP -0.107837194192191 0.0316945337101689 NA NA NA hsa-miR-106a-5p TSPYL5 2.48882002962836 1.99757727374521e-12 -1.27853401161082 0.00879588535226036 mirMAP -0.150095484267398 0.0214012750012032 NA NA NA hsa-miR-106a-5p TTC28 2.48882002962836 1.99757727374521e-12 -1.4343015117923 3.9286632197558e-07 mirMAP -0.123562986217466 0.00117321385355015 NA NA NA hsa-miR-106a-5p TXNIP 2.48882002962836 1.99757727374521e-12 -1.19206229218288 1.53140877295634e-05 MirTarget -0.177056976927819 1.39287485258321e-06 NA NA NA hsa-miR-106a-5p UBE2Q2 2.48882002962836 1.99757727374521e-12 -0.786021468971091 2.04263029736963e-07 MirTarget;miRNATAP -0.110066799017255 4.3484605774586e-08 NA NA NA hsa-miR-106a-5p ZBTB4 2.48882002962836 1.99757727374521e-12 -1.18036868632639 2.4625945711519e-17 MirTarget;miRNATAP -0.127437106087051 1.26586713170887e-11 NA NA NA hsa-miR-106a-5p ZBTB47 2.48882002962836 1.99757727374521e-12 -1.27249050834428 5.23741533445086e-13 miRNAWalker2_validate;MirTarget -0.149771502296146 2.39737971296224e-10 NA NA NA hsa-miR-106a-5p ZDHHC1 2.48882002962836 1.99757727374521e-12 -0.844784001804035 0.0003218361569338 MirTarget;miRNATAP -0.100233347537713 0.00140070104344002 NA NA NA hsa-miR-106a-5p ZFPM2 2.48882002962836 1.99757727374521e-12 -3.29884457958359 4.34537841593148e-12 miRNATAP -0.627446467264283 2.28695430558767e-24 NA NA NA hsa-miR-106a-5p ZHX3 2.48882002962836 1.99757727374521e-12 -1.25748004404002 1.76656564054041e-14 mirMAP -0.133757318726503 1.49319819845706e-09 NA NA NA hsa-miR-106a-5p ZMAT3 2.48882002962836 1.99757727374521e-12 -0.834456180454181 0.000338643864818007 mirMAP -0.142469467536183 4.02360691529699e-06 NA NA NA hsa-miR-106a-5p ZNF25 2.48882002962836 1.99757727374521e-12 -1.20036862235946 6.14085039950356e-14 miRNATAP -0.144148007715693 1.7501054902626e-11 NA NA NA hsa-miR-106a-5p ZNF280B 2.48882002962836 1.99757727374521e-12 -1.31579833605866 0.00759832510998532 MirTarget -0.172660902519739 0.00873048190004638 NA NA NA hsa-miR-106a-5p ZNF532 2.48882002962836 1.99757727374521e-12 -0.642348594400126 0.00482300004408463 MirTarget -0.100741626514536 0.000898695018049708 NA NA NA