miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-125a-5p	CCR5	-1.32352790615388	0.00714301627309467	1.27043041452183	0.172981356553001	miRanda	-0.327506852009468	0.00234219128645621		NA	NA	NA
hsa-miR-501-5p	CCR5	1.0411896821345	0.0777206709183552	1.27043041452183	0.172981356553001	mirMAP	-0.181108347581225	0.0442686887601303		NA	NA	NA
hsa-miR-93-3p	CCR5	2.62833115374128	2.28843227834337e-07	1.27043041452183	0.172981356553001	MirTarget	-0.423129384842028	3.26389763821151e-05		NA	NA	NA
hsa-miR-103a-3p	CD274	0.990919087251708	0.00468308601422847	2.22279412449515	0.0516111370736547	miRNAWalker2_validate	-0.483901377020577	0.010127083096146		NA	NA	NA
hsa-miR-106a-5p	CD274	3.98693608217557	9.37722470816656e-07	2.22279412449515	0.0516111370736547	MirTarget	-0.236984996685837	0.00244589289765692		NA	NA	NA
hsa-miR-182-5p	CD274	5.86988712704738	1.22411588571584e-15	2.22279412449515	0.0516111370736547	mirMAP	-0.339706442437269	4.80944840181619e-05		NA	NA	NA
hsa-miR-200a-3p	CD274	6.336081120041	4.024313571871e-16	2.22279412449515	0.0516111370736547	MirTarget	-0.349325798251526	8.24128678574652e-06		NA	NA	NA
hsa-miR-20b-5p	CD274	4.5662923200279	4.75238200639144e-05	2.22279412449515	0.0516111370736547	MirTarget	-0.192258791595886	0.000703899942107355	24468585	These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer		colorectal cancer
hsa-miR-324-5p	CD274	1.31253452379847	0.0116806680545163	2.22279412449515	0.0516111370736547	miRanda	-0.47313482826795	0.000139757569599412		NA	NA	NA
hsa-miR-429	CD274	6.39965293994036	1.96920201593608e-18	2.22279412449515	0.0516111370736547	miRanda	-0.414756964042163	4.97744617535068e-07		NA	NA	NA
hsa-miR-497-5p	CD274	-1.44150596209372	0.0225146607606395	2.22279412449515	0.0516111370736547	MirTarget	-0.383087599725002	0.000175050271995498		NA	NA	NA
hsa-miR-93-5p	CD274	2.65964181833033	2.58315947526774e-08	2.22279412449515	0.0516111370736547	MirTarget	-0.455113489627987	0.000638032417442551		NA	NA	NA
hsa-miR-15b-5p	CD80	3.32329949959268	8.40210501034588e-13	1.85820500486921	0.0387588872001837	MirTarget	-0.212675070259197	0.0466936690347407		NA	NA	NA
hsa-miR-429	CD80	6.39965293994036	1.96920201593608e-18	1.85820500486921	0.0387588872001837	miRanda	-0.307468226285038	2.33512512638037e-06		NA	NA	NA
hsa-miR-497-5p	CD80	-1.44150596209372	0.0225146607606395	1.85820500486921	0.0387588872001837	MirTarget	-0.229775995283895	0.00444312947687262		NA	NA	NA
hsa-miR-181b-5p	JAK2	1.11397227523501	0.0273417050354018	-0.336326790557259	0.592787818955037	mirMAP	-0.192618204419721	0.00651043610634605		NA	NA	NA
hsa-miR-335-5p	JAK2	0.167216045757305	0.803897055331049	-0.336326790557259	0.592787818955037	miRNAWalker2_validate	-0.209615118003146	6.79293979136461e-05		NA	NA	NA
hsa-miR-106b-5p	PTEN	2.80565545918114	1.14547999022566e-09	-0.848820542036926	0.0698463061072717	miRNAWalker2_validate;miRTarBase	-0.111776315347317	0.0482864718495211	24842611;26238857;26722252	MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells	cell migration;drug resistance;	gastric cancer;colorectal cancer;breast cancer
hsa-miR-130b-3p	PTEN	3.9204771543282	1.2714917955808e-11	-0.848820542036926	0.0698463061072717	MirTarget	-0.139961927957452	0.00157623535045685	26837847;25637514	The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC	cell migration;	bladder cancer;esophageal cancer
hsa-miR-15b-3p	PTEN	3.57530146629867	5.89922785773482e-11	-0.848820542036926	0.0698463061072717	mirMAP	-0.101678639528678	0.0316428561568647		NA	NA	NA
hsa-miR-182-5p	PTEN	5.86988712704738	1.22411588571584e-15	-0.848820542036926	0.0698463061072717	mirMAP	-0.100967623222909	0.00331619412338393		NA	NA	NA
hsa-miR-186-5p	PTEN	0.445443449112564	0.185447310527704	-0.848820542036926	0.0698463061072717	mirMAP	-0.200308952808133	0.0131231949585673		NA	NA	NA
hsa-miR-188-5p	PTEN	1.39111178824125	0.0251592818948912	-0.848820542036926	0.0698463061072717	MirTarget	-0.123015522557534	0.0041039297017108		NA	NA	NA
hsa-miR-200b-3p	PTEN	5.56167217794639	6.43540045061709e-16	-0.848820542036926	0.0698463061072717	TargetScan;mirMAP	-0.111724552597797	0.00227683849654151	22637745;21408027	Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants	;	pancreatic cancer;pancreatic cancer
hsa-miR-25-3p	PTEN	1.12623030168869	0.00311079344417173	-0.848820542036926	0.0698463061072717	miRTarBase;MirTarget	-0.346634698468156	5.85013644059584e-07		NA	NA	NA
hsa-miR-28-5p	PTEN	-0.815636722979196	0.0221199948901761	-0.848820542036926	0.0698463061072717	miRanda	-0.201833894647843	0.00766209794137583		NA	NA	NA
hsa-miR-30e-3p	PTEN	-0.0362193022195196	0.932577027239525	-0.848820542036926	0.0698463061072717	MirTarget	-0.140930642956691	0.0250533090635572		NA	NA	NA
hsa-miR-32-3p	PTEN	2.20477794939766	0.0392771274032852	-0.848820542036926	0.0698463061072717	mirMAP	-0.128718962710161	0.00318430811052814	24123284;25647261;23617834	In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC; The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction; The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed; Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues; An inverse relationship between miR-32 and PTEN protein expression was identified; MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR 32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN; Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway; Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment;MicroRNA 32 miR 32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells; In this study we identified the potential effects of miR-32 on some important biological properties of CRC cells and clarified the regulation of PTEN by miR-32; The 3'-untranslated region 3'-UTR of PTEN combined with miR-32 was verified by dual-luciferase reporter assay; Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level; However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein; In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN; Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN	;;tumorigenesis	colorectal cancer;liver cancer;colorectal cancer
hsa-miR-374a-5p	PTEN	0.278549982012055	0.45888283715888	-0.848820542036926	0.0698463061072717	MirTarget;mirMAP	-0.174023162661546	0.0155107520726896		NA	NA	NA
hsa-miR-374b-5p	PTEN	-0.114749866169918	0.764888930049438	-0.848820542036926	0.0698463061072717	MirTarget;mirMAP	-0.184462823771875	0.00876765791811961		NA	NA	NA
hsa-miR-421	PTEN	1.97624148591545	0.000915838012451138	-0.848820542036926	0.0698463061072717	miRanda	-0.135924707077455	0.00219014673757631		NA	NA	NA
hsa-miR-532-5p	PTEN	-0.297424983759107	0.503934707453099	-0.848820542036926	0.0698463061072717	mirMAP	-0.208656603286142	0.000512381739154765		NA	NA	NA
hsa-miR-590-3p	PTEN	2.35429565068338	2.79601879608564e-06	-0.848820542036926	0.0698463061072717	MirTarget;miRanda;mirMAP	-0.140657129239091	0.00714320619469358	23803188	Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting; miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation		liver cancer
hsa-miR-7-1-3p	PTEN	1.43074343339835	0.00471215970502094	-0.848820542036926	0.0698463061072717	mirMAP	-0.176200102858594	0.000755349982671746		NA	NA	NA
hsa-miR-93-5p	PTEN	2.65964181833033	2.58315947526774e-08	-0.848820542036926	0.0698463061072717	miRNAWalker2_validate;miRTarBase	-0.180023874518816	0.000957550001063743	25633810;26243299;22465665;26087719	MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression	;tumorigenesis;;poor survival	liver cancer;sarcoma;ovarian cancer;ovarian cancer
hsa-miR-129-5p	STAT1	-2.66843722411409	0.00695783358331245	2.01274955437017	0.00163940367755263	miRanda	-0.132968133978279	0.000332779406279412		NA	NA	NA
hsa-miR-143-5p	STAT1	-1.23893144572919	0.0631644173977607	2.01274955437017	0.00163940367755263	MirTarget	-0.278466307388879	2.29950756322775e-07		NA	NA	NA
hsa-miR-145-5p	STAT1	-3.55505374822025	5.45525288912869e-07	2.01274955437017	0.00163940367755263	miRNAWalker2_validate;miRTarBase	-0.301283748877802	9.42789762512279e-10	20098684	MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets		colon cancer
hsa-miR-182-5p	STAT1	5.86988712704738	1.22411588571584e-15	2.01274955437017	0.00163940367755263	mirMAP	-0.141741106320013	0.00269792907366131		NA	NA	NA
hsa-miR-30c-2-3p	STAT1	-0.916427677918778	0.300195789569016	2.01274955437017	0.00163940367755263	MirTarget	-0.168573272016947	3.67612990391486e-05		NA	NA	NA
hsa-miR-34a-5p	STAT1	0.830377770217786	0.0477544831885907	2.01274955437017	0.00163940367755263	miRNAWalker2_validate	-0.269576975538692	0.00211365779456242		NA	NA	NA
hsa-miR-361-5p	STAT1	0.00649167180664723	0.985202350239079	2.01274955437017	0.00163940367755263	miRanda	-0.463679155021812	1.101952208681e-05		NA	NA	NA
hsa-miR-495-3p	STAT1	-1.28495103468384	0.0979462503954353	2.01274955437017	0.00163940367755263	MirTarget	-0.167329201002395	0.000346028566784044		NA	NA	NA
hsa-miR-532-3p	STAT1	0.643755490841218	0.214842585969913	2.01274955437017	0.00163940367755263	MirTarget	-0.236799777603778	0.000777789771112861		NA	NA	NA
hsa-miR-96-5p	STAT1	5.62521466029286	1.54938806718028e-10	2.01274955437017	0.00163940367755263	mirMAP	-0.211622398008511	1.44467949291041e-05		NA	NA	NA
hsa-miR-125a-5p	STAT2	-1.32352790615388	0.00714301627309467	0.867646241695998	0.0419134711672987	miRNAWalker2_validate	-0.100029081050198	0.0428169688480086		NA	NA	NA
hsa-miR-335-5p	STAT2	0.167216045757305	0.803897055331049	0.867646241695998	0.0419134711672987	miRNAWalker2_validate	-0.100797534173916	0.00505999447261084		NA	NA	NA
hsa-miR-339-5p	STAT2	1.23326828594484	0.0307501214818698	0.867646241695998	0.0419134711672987	miRanda	-0.109661316007533	0.00972781086346445		NA	NA	NA
hsa-miR-432-5p	STAT2	-1.04688139137176	0.21678663577335	0.867646241695998	0.0419134711672987	MirTarget	-0.129653971260457	5.15928370583859e-06		NA	NA	NA
hsa-miR-29a-5p	TRAF6	0.0748295222568571	0.884125894063293	-0.433986140670238	0.255703111868558	MirTarget;mirMAP	-0.131349460411584	0.00187386742085026		NA	NA	NA
hsa-miR-335-3p	TRAF6	1.19503568251824	0.0938852560631551	-0.433986140670238	0.255703111868558	MirTarget	-0.103633187493345	0.000576193925904453		NA	NA	NA
hsa-miR-374b-5p	TRAF6	-0.114749866169918	0.764888930049438	-0.433986140670238	0.255703111868558	mirMAP	-0.178980277400146	0.0017125695274895		NA	NA	NA
hsa-miR-497-5p	TRAF6	-1.44150596209372	0.0225146607606395	-0.433986140670238	0.255703111868558	MirTarget	-0.112318911916622	0.000957235438651535		NA	NA	NA