miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-708-5p ADAMTS15 3.38051631555486 5.12590198690777e-18 -2.81260327679564 2.75117079085055e-06 mirMAP -0.183927183698919 0.0107287412220875 NA NA NA hsa-miR-708-5p ADCY9 3.38051631555486 5.12590198690777e-18 -1.49969795166377 5.91319152843764e-09 mirMAP -0.106366333408186 0.000614959945717879 NA NA NA hsa-miR-708-5p AMOTL2 3.38051631555486 5.12590198690777e-18 -1.01147657574476 0.000152881926388237 miRNATAP -0.141025724560665 8.50819396477288e-06 NA NA NA hsa-miR-708-5p ASPA 3.38051631555486 5.12590198690777e-18 -4.7558815937205 3.44505820704593e-17 MirTarget -0.409492766139174 2.33379401973292e-09 NA NA NA hsa-miR-708-5p ATRNL1 3.38051631555486 5.12590198690777e-18 -2.47727125743926 3.25226427695129e-06 MirTarget -0.253908902074837 6.52853684381799e-05 NA NA NA hsa-miR-708-5p CAMK1D 3.38051631555486 5.12590198690777e-18 -0.520889022126772 0.156691798027969 mirMAP -0.118671131160369 0.00654174719931367 NA NA NA hsa-miR-708-5p CAPN6 3.38051631555486 5.12590198690777e-18 -3.47799832819863 8.37155036573641e-07 miRNATAP -0.23018941663005 0.0067115491501721 NA NA NA hsa-miR-708-5p CBX6 3.38051631555486 5.12590198690777e-18 -1.53953176885359 2.83932741324751e-07 mirMAP -0.141619499039778 8.02455473769092e-05 NA NA NA hsa-miR-708-5p CCDC141 3.38051631555486 5.12590198690777e-18 -2.93849988362368 3.4694116937076e-12 mirMAP -0.180553192364487 0.00043816610649712 NA NA NA hsa-miR-708-5p CCND2 3.38051631555486 5.12590198690777e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.19367896307831 2.62089031491477e-05 NA NA NA hsa-miR-708-5p CNTN2 3.38051631555486 5.12590198690777e-18 -3.83211666052187 2.86131751350646e-14 mirMAP -0.146438528982934 0.0179201239797862 NA NA NA hsa-miR-708-5p DPF3 3.38051631555486 5.12590198690777e-18 -1.66550931035639 8.31086463953742e-06 mirMAP -0.174198501764556 9.3975699290947e-05 NA NA NA hsa-miR-708-5p DUSP3 3.38051631555486 5.12590198690777e-18 -1.04472877082381 6.16231013810421e-12 mirMAP -0.119082024648545 4.39781330963206e-11 NA NA NA hsa-miR-708-5p FAIM2 3.38051631555486 5.12590198690777e-18 -5.19306317048563 1.8116701555082e-19 MirTarget -0.199613695331998 0.00525316691536954 NA NA NA hsa-miR-708-5p FAM107A 3.38051631555486 5.12590198690777e-18 -5.00865420988181 1.32570913157414e-25 MirTarget -0.297523755212713 6.68395115762265e-07 NA NA NA hsa-miR-708-5p FOXN3 3.38051631555486 5.12590198690777e-18 -1.43525991184281 2.70084540955391e-16 MirTarget;miRNATAP -0.110370172034966 2.24946563133726e-07 NA NA NA hsa-miR-708-5p FREM1 3.38051631555486 5.12590198690777e-18 -3.09994316432966 3.22977226498842e-07 MirTarget -0.291978812745866 5.87147319545595e-05 NA NA NA hsa-miR-708-5p FZD4 3.38051631555486 5.12590198690777e-18 -0.82842258037894 0.00067769989049317 miRNATAP -0.126330673307189 1.20305402790233e-05 NA NA NA hsa-miR-708-5p GNAO1 3.38051631555486 5.12590198690777e-18 -3.60402838064813 1.60858876204295e-14 mirMAP -0.254364268434577 8.61678072458247e-06 NA NA NA hsa-miR-708-5p GPM6A 3.38051631555486 5.12590198690777e-18 -4.42956657098415 1.14589092196157e-14 miRNATAP -0.28930249805916 3.59975945526459e-05 NA NA NA hsa-miR-708-5p GSTT2 3.38051631555486 5.12590198690777e-18 -0.452614895297062 0.256762898569484 MirTarget -0.111056889871571 0.0191164040910542 NA NA NA hsa-miR-708-5p KIF13B 3.38051631555486 5.12590198690777e-18 -1.03626427278681 9.1423073198281e-08 mirMAP -0.116507723035995 4.50979669294729e-07 NA NA NA hsa-miR-708-5p MAP1B 3.38051631555486 5.12590198690777e-18 -3.18358434812783 4.83606017602339e-16 MirTarget -0.188216655196132 9.0864796207319e-05 NA NA NA hsa-miR-708-5p MASP1 3.38051631555486 5.12590198690777e-18 -4.42879244536494 1.13039922494912e-18 MirTarget -0.319364591909506 2.13030285728822e-07 NA NA NA hsa-miR-708-5p NDRG2 3.38051631555486 5.12590198690777e-18 -0.789719444840141 0.0343133748314898 miRNATAP -0.10066027319924 0.0233863822433729 NA NA NA hsa-miR-708-5p NFIC 3.38051631555486 5.12590198690777e-18 -1.57099939804843 8.09399770340134e-09 mirMAP -0.15732300376584 1.39446782894664e-06 NA NA NA hsa-miR-708-5p NNAT 3.38051631555486 5.12590198690777e-18 -2.92307658732051 1.96432494203206e-06 MirTarget;miRNATAP -0.32631934071215 8.49466449927525e-06 26075749 Metformin promotes increased expression of miR-708-5p leading to suppression of endoplasmic reticulum ER membrane protein neuronatin NNAT expression and subsequently induces apoptosis of prostate cancer cells through the ER stress pathway; This novel regulatory mechanism of metformin in prostate cancer cells not only advances our knowledge on the molecular mechanism of metformin but also provides a promising therapeutic strategy by targeting miR-708-5p and NNAT for prostate cancer treatment staging prostate cancer hsa-miR-708-5p NPTXR 3.38051631555486 5.12590198690777e-18 -1.27007332081844 0.0130597711013763 mirMAP -0.140492743439565 0.0211814583600704 NA NA NA hsa-miR-708-5p NTRK3 3.38051631555486 5.12590198690777e-18 -5.17034960965042 5.23662623079398e-21 mirMAP -0.264793679956677 0.00010594308520104 NA NA NA hsa-miR-708-5p PDZD4 3.38051631555486 5.12590198690777e-18 -3.50328419678476 5.69234493908284e-16 miRNATAP -0.152475552244405 0.00420461167119288 NA NA NA hsa-miR-708-5p PITPNM3 3.38051631555486 5.12590198690777e-18 -1.79250302161575 2.85103802199208e-05 MirTarget -0.101780935478864 0.047694457350203 NA NA NA hsa-miR-708-5p PPP1R12B 3.38051631555486 5.12590198690777e-18 -3.46376452255787 1.1364412732345e-26 mirMAP -0.308111225984891 9.4157547330608e-15 NA NA NA hsa-miR-708-5p PTGS1 3.38051631555486 5.12590198690777e-18 -4.35917875057969 2.59003994200608e-15 miRNAWalker2_validate -0.275318410187185 4.41309801115416e-05 NA NA NA hsa-miR-708-5p PTGS2 3.38051631555486 5.12590198690777e-18 -2.90239684568393 1.42525690641941e-08 MirTarget -0.219131957644256 0.000378564332135072 NA NA NA hsa-miR-708-5p PXK 3.38051631555486 5.12590198690777e-18 -1.04685086128216 1.54718294430705e-05 MirTarget -0.127650251289525 9.26392588813891e-06 NA NA NA hsa-miR-708-5p RASSF2 3.38051631555486 5.12590198690777e-18 -1.41203583911444 3.41019630784437e-05 MirTarget -0.152170371807832 0.000180084407948154 NA NA NA hsa-miR-708-5p RGL1 3.38051631555486 5.12590198690777e-18 -1.51925487686695 6.14848968356696e-09 MirTarget -0.130856434448339 3.06631864971669e-05 NA NA NA hsa-miR-708-5p RHOBTB2 3.38051631555486 5.12590198690777e-18 -0.430436551705903 0.154729551320481 mirMAP -0.121887845243098 0.000660392841393795 NA NA NA hsa-miR-708-5p SARM1 3.38051631555486 5.12590198690777e-18 -0.737978260164684 0.0157690645220246 MirTarget -0.135248110681799 0.000186986440052378 NA NA NA hsa-miR-708-5p SCUBE1 3.38051631555486 5.12590198690777e-18 -2.96312252629411 1.19663542889144e-10 MirTarget -0.234210802959322 2.48091662999225e-05 NA NA NA hsa-miR-708-5p STARD8 3.38051631555486 5.12590198690777e-18 -1.75930604958348 9.33516853968586e-11 MirTarget -0.112377095365684 0.000633931695212258 NA NA NA hsa-miR-708-5p SYNPO 3.38051631555486 5.12590198690777e-18 -1.74025803466879 1.56969745033557e-11 miRNATAP -0.134416869752816 1.63883741380426e-05 NA NA NA hsa-miR-708-5p TMEM88 3.38051631555486 5.12590198690777e-18 -1.7214574147876 1.86437274907679e-10 miRNAWalker2_validate;miRTarBase -0.116389919967538 0.000367046091922984 22573352 The transcript for TMEM88 gene has a miR-708 binding site in its 3' UTR and was significantly reduced in tumors high of miR-708; Forced miR-708 expression reduced TMEM88 transcript levels and increased the rate of cell proliferation invasion and migration in culture lung cancer hsa-miR-708-5p TNS1 3.38051631555486 5.12590198690777e-18 -3.79443812838711 2.14081599635649e-21 mirMAP -0.310148822879287 2.34998855130399e-10 NA NA NA hsa-miR-708-5p WNK3 3.38051631555486 5.12590198690777e-18 -1.25332787095286 0.00861836442540923 MirTarget -0.191608529673307 0.000719903860303187 NA NA NA hsa-miR-708-5p WNT9A 3.38051631555486 5.12590198690777e-18 -2.06944914631955 1.31351479409276e-06 mirMAP -0.177570506962564 0.000533342150132389 NA NA NA hsa-miR-708-5p ZC3H12B 3.38051631555486 5.12590198690777e-18 -1.7963764364757 2.55471828386792e-07 miRNATAP -0.109139193974679 0.00931678562484494 NA NA NA