miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-145-5p	ADAM17	-3.55505374822025	5.45525288912869e-07	1.45955836376737	0.0071576842489971	miRNAWalker2_validate	-0.113195711187901	0.00805902718472499	25174729;23441135	MicroRNA 145 inhibits cell proliferation by directly targeting ADAM17 in hepatocellular carcinoma; In the present study we showed that miR-145 is able to significantly reduce mRNA and protein expression levels of A disintegrin and metalloproteinase 17 ADAM17 in liver cancer cells SMMC-7721 BEL-7402 and Huh-7; Dual luciferase reporter assays confirmed that ADAM17 is a direct target of miR-145; In conclusion miR-145 inhibits liver cancer cell proliferation by directly targeting ADAM17;MicroRNA 145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients; Furthermore we show that ADAM17 negatively regulates miR-145 through tumor necrosis factor-α resulting in a reciprocal negative feedback loop; In this study the expression of ADAM17 and miR-145 correlated negatively in renal cancer tumor tissues and cell lines suggesting an important regulatory mechanism; Additionally we showed that the regulation of ADAM17 is partly involved in the effects of miR-145 on proliferation and migration whereas no involvement in chemosensitivity was observed; In summary miR-145 is downregulated in renal cancer patients which leads to the up-regulation of ADAM17 in renal cancer; Importantly miR-145 and ADAM17 are regulated in a reciprocal negative feedback loop	;	liver cancer;kidney renal cell cancer
hsa-miR-21-3p	CREBBP	3.50297439576639	6.39946844099206e-10	-0.3958302023172	0.180670093990074	MirTarget	-0.1378273582574	1.08112070034993e-06		NA	NA	NA
hsa-miR-590-3p	CREBBP	2.35429565068338	2.79601879608564e-06	-0.3958302023172	0.180670093990074	PITA;miRanda;mirMAP;miRNATAP	-0.100352894791816	0.00219317602458258		NA	NA	NA
hsa-miR-342-3p	CTBP2	1.31107714473009	0.0207211910724662	-0.534858240246571	0.121949363819826	MirTarget;PITA;miRanda;miRNATAP	-0.126298130193261	0.000232764023108101		NA	NA	NA
hsa-miR-34a-5p	DLL1	0.830377770217786	0.0477544831885907	-1.04758719887865	0.274770371263425	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.371966874099855	0.00450346074419271	22438124	Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells		lung squamous cell cancer
hsa-miR-429	DLL1	6.39965293994036	1.96920201593608e-18	-1.04758719887865	0.274770371263425	miRanda;miRNATAP	-0.182212967670452	0.00942012873083251		NA	NA	NA
hsa-let-7a-3p	DLL4	0.82512001802525	0.0468122405194487	-2.40940779827278	3.55656079079277e-05	miRNATAP	-0.270896547980813	0.00084560213536036		NA	NA	NA
hsa-let-7b-3p	DLL4	0.589364128513318	0.200507534602851	-2.40940779827278	3.55656079079277e-05	miRNATAP	-0.385572111460411	8.65088869793906e-08		NA	NA	NA
hsa-miR-15b-5p	DLL4	3.32329949959268	8.40210501034588e-13	-2.40940779827278	3.55656079079277e-05	miRNATAP	-0.323829778100093	2.62130613528265e-06		NA	NA	NA
hsa-miR-16-5p	DLL4	2.93575808220754	2.15436817162977e-10	-2.40940779827278	3.55656079079277e-05	miRNATAP	-0.336563248138901	1.42108586851175e-06		NA	NA	NA
hsa-miR-429	DLL4	6.39965293994036	1.96920201593608e-18	-2.40940779827278	3.55656079079277e-05	miRanda	-0.182419803124271	1.96555303094802e-05		NA	NA	NA
hsa-miR-3199	DTX1	-0.378073255285181	0.529787553996525	-0.0591770253497437	0.93478174645003	miRNATAP	-0.241607077941039	0.000513165818413666		NA	NA	NA
hsa-miR-421	DTX1	1.97624148591545	0.000915838012451138	-0.0591770253497437	0.93478174645003	PITA;miRanda;miRNATAP	-0.185965679215973	0.00670536900684234		NA	NA	NA
hsa-let-7e-5p	DTX2	-0.111012524740586	0.814744515884005	1.72458760902201	0.000435262111312831	miRNATAP	-0.198546875288587	0.000842610034473319		NA	NA	NA
hsa-miR-92b-3p	DTX2	1.69303761469782	0.0103484911955574	1.72458760902201	0.000435262111312831	miRNATAP	-0.20805023335582	6.00976421874252e-07		NA	NA	NA
hsa-miR-185-5p	DTX3	2.46768243458192	6.53179875424217e-08	-1.87317511719605	0.00193979416468299	MirTarget	-0.25807179418495	0.000505411752733169		NA	NA	NA
hsa-miR-182-5p	DTX3L	5.86988712704738	1.22411588571584e-15	1.50317881809768	0.000344752084326122	mirMAP	-0.122019542064078	7.76759962917857e-05		NA	NA	NA
hsa-miR-186-5p	DTX3L	0.445443449112564	0.185447310527704	1.50317881809768	0.000344752084326122	MirTarget	-0.21979013105654	0.00252496088358328		NA	NA	NA
hsa-miR-493-5p	DTX3L	0.170487141312394	0.834200945899452	1.50317881809768	0.000344752084326122	MirTarget	-0.122224313758419	2.90406345336232e-05		NA	NA	NA
hsa-miR-495-3p	DTX3L	-1.28495103468384	0.0979462503954353	1.50317881809768	0.000344752084326122	mirMAP	-0.12554109008555	4.15886529447827e-05		NA	NA	NA
hsa-let-7a-5p	DTX4	0.148081801547773	0.645305441523746	0.516461139012338	0.535806750515158	TargetScan;miRNATAP	-0.59377576975932	7.42202563258467e-05		NA	NA	NA
hsa-let-7b-5p	DTX4	-0.189422992330471	0.651878220048983	0.516461139012338	0.535806750515158	miRNATAP	-0.336007505852372	0.0031922878263835		NA	NA	NA
hsa-let-7f-5p	DTX4	0.971961126099146	0.0240319857511033	0.516461139012338	0.535806750515158	miRNATAP	-0.292079193734023	0.00832136656034974		NA	NA	NA
hsa-miR-125b-5p	DTX4	-2.01187572101832	0.00516480893645494	0.516461139012338	0.535806750515158	mirMAP;miRNATAP	-0.228583395010548	0.000446826754103129		NA	NA	NA
hsa-miR-27a-3p	DTX4	1.76094007417453	0.000216137556256765	0.516461139012338	0.535806750515158	miRNATAP	-0.278748155781989	0.00489499048166595		NA	NA	NA
hsa-miR-27b-3p	DTX4	-0.0929089601968123	0.85847352206581	0.516461139012338	0.535806750515158	miRNATAP	-0.380478293242262	2.66849178482289e-05		NA	NA	NA
hsa-miR-10a-5p	DVL1	-0.482300926520507	0.594608783320466	0.0930830936484925	0.802605048970877	miRNAWalker2_validate	-0.11026504710669	1.40870159993299e-06		NA	NA	NA
hsa-miR-125a-5p	DVL3	-1.32352790615388	0.00714301627309467	0.712696667163076	0.0441831929271895	PITA	-0.114291084779072	0.00510375398533769		NA	NA	NA
hsa-miR-146b-3p	DVL3	1.34608871980101	0.00935728391852709	0.712696667163076	0.0441831929271895	MirTarget	-0.152558917031062	7.36274039601236e-05		NA	NA	NA
hsa-miR-29b-2-5p	DVL3	-0.596051745078872	0.189540844841389	0.712696667163076	0.0441831929271895	MirTarget	-0.119308522306106	0.00736926175410278		NA	NA	NA
hsa-miR-30a-3p	DVL3	-1.22212086897848	0.167565797592104	0.712696667163076	0.0441831929271895	MirTarget	-0.122406816743673	3.30206813290696e-08		NA	NA	NA
hsa-miR-148a-3p	EP300	1.1031350648218	0.052038169812979	0.224331914964019	0.578934208058052	miRNATAP	-0.104185690998739	0.00975228544208279		NA	NA	NA
hsa-miR-30c-5p	EP300	0.38723991118075	0.348605235643473	0.224331914964019	0.578934208058052	miRNAWalker2_validate	-0.18542784496307	0.000897194160521004		NA	NA	NA
hsa-miR-339-5p	EP300	1.23326828594484	0.0307501214818698	0.224331914964019	0.578934208058052	miRanda	-0.199156483102611	4.47682764951844e-07		NA	NA	NA
hsa-miR-342-3p	EP300	1.31107714473009	0.0207211910724662	0.224331914964019	0.578934208058052	MirTarget;PITA;miRanda;miRNATAP	-0.115722711407846	0.00406603413994019		NA	NA	NA
hsa-miR-374b-5p	EP300	-0.114749866169918	0.764888930049438	0.224331914964019	0.578934208058052	mirMAP;miRNATAP	-0.159199926258203	0.00855691297646884		NA	NA	NA
hsa-miR-590-3p	EP300	2.35429565068338	2.79601879608564e-06	0.224331914964019	0.578934208058052	MirTarget;PITA;miRanda;mirMAP;miRNATAP	-0.136964991854083	0.00229030845745203		NA	NA	NA
hsa-miR-146b-5p	HDAC2	1.87569569182453	0.000737241069698886	0.396222421819743	0.222645527527983	mirMAP	-0.118359476413122	0.000294943660548267		NA	NA	NA
hsa-miR-324-5p	HES1	1.31253452379847	0.0116806680545163	0.727729542169358	0.152969751416319	miRanda	-0.147628694100491	0.00784776532068186		NA	NA	NA
hsa-miR-128-3p	JAG1	1.36248409467631	0.00408435995818078	0.30392833382371	0.667161126642582	MirTarget	-0.240292405805989	0.00447381926479373		NA	NA	NA
hsa-miR-129-5p	JAG1	-2.66843722411409	0.00695783358331245	0.30392833382371	0.667161126642582	PITA;miRanda;miRNATAP	-0.108888930663134	0.00768738914451679		NA	NA	NA
hsa-miR-141-3p	JAG1	7.30474126597325	1.45115996357606e-24	0.30392833382371	0.667161126642582	TargetScan;miRNATAP	-0.24949464372282	1.00127755561837e-06		NA	NA	NA
hsa-miR-186-5p	JAG1	0.445443449112564	0.185447310527704	0.30392833382371	0.667161126642582	MirTarget;miRNATAP	-0.483497812934152	6.29925741427896e-05		NA	NA	NA
hsa-miR-200a-3p	JAG1	6.336081120041	4.024313571871e-16	0.30392833382371	0.667161126642582	miRNATAP	-0.262410845489823	4.31839076896454e-08		NA	NA	NA
hsa-miR-200c-3p	JAG1	6.47012025883743	2.64500707716408e-26	0.30392833382371	0.667161126642582	miRNAWalker2_validate	-0.227366368433358	0.000148958094017213		NA	NA	NA
hsa-miR-26b-3p	JAG1	0.985177548213122	0.0351427970185971	0.30392833382371	0.667161126642582	miRNATAP	-0.268721222273302	0.0017697133626912		NA	NA	NA
hsa-miR-335-5p	JAG1	0.167216045757305	0.803897055331049	0.30392833382371	0.667161126642582	miRNATAP	-0.25177907540644	2.00426159484671e-05		NA	NA	NA
hsa-miR-34a-5p	JAG1	0.830377770217786	0.0477544831885907	0.30392833382371	0.667161126642582	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.402626505574248	2.53093201072412e-05		NA	NA	NA
hsa-miR-361-3p	JAG1	0.805698609170807	0.0418491665498322	0.30392833382371	0.667161126642582	miRNATAP	-0.343480437185011	0.000760307662275423		NA	NA	NA
hsa-miR-375	JAG1	3.3784490463318	0.0449946294355695	0.30392833382371	0.667161126642582	miRNAWalker2_validate	-0.189741948484455	2.47458537541398e-17		NA	NA	NA
hsa-miR-429	JAG1	6.39965293994036	1.96920201593608e-18	0.30392833382371	0.667161126642582	miRanda	-0.198906058180212	0.000105144442495419		NA	NA	NA
hsa-miR-628-5p	JAG1	1.04832355434705	0.0252368809675445	0.30392833382371	0.667161126642582	MirTarget;PITA;miRNATAP	-0.326781464845399	0.000133888642673117		NA	NA	NA
hsa-miR-93-3p	JAG1	2.62833115374128	2.28843227834337e-07	0.30392833382371	0.667161126642582	MirTarget;miRNATAP	-0.246791520115182	0.00145198879787158		NA	NA	NA
hsa-miR-140-3p	JAG2	-1.9828800596692	8.92876132959514e-08	0.719956532794578	0.281629881835633	miRNATAP	-0.285234424379722	0.00500810976910623		NA	NA	NA
hsa-miR-106b-5p	KAT2B	2.80565545918114	1.14547999022566e-09	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate;miRTarBase;MirTarget	-0.275926867148753	6.1000129405317e-06		NA	NA	NA
hsa-miR-125a-3p	KAT2B	-0.0748960586927341	0.920735897434087	-1.07154210738308	0.0359102937350788	miRanda	-0.159279622481074	3.19647064838164e-05		NA	NA	NA
hsa-miR-17-5p	KAT2B	2.3269271449522	2.13987445663942e-05	-1.07154210738308	0.0359102937350788	MirTarget;TargetScan	-0.215486293230893	3.48849938663729e-05	23095762	miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells		prostate cancer
hsa-miR-181b-5p	KAT2B	1.11397227523501	0.0273417050354018	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate;miRTarBase;MirTarget	-0.174334008919978	0.00245276600751652		NA	NA	NA
hsa-miR-181d-5p	KAT2B	-0.529098579553155	0.325262124523294	-1.07154210738308	0.0359102937350788	MirTarget	-0.16972920981897	0.0016982969151703		NA	NA	NA
hsa-miR-19b-3p	KAT2B	1.67581705793313	0.000858910586302716	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate	-0.199723227384206	0.000498102929803726		NA	NA	NA
hsa-miR-20a-3p	KAT2B	1.9920766549842	0.000624458530894697	-1.07154210738308	0.0359102937350788	MirTarget	-0.284629456748677	4.2729756695455e-09		NA	NA	NA
hsa-miR-25-3p	KAT2B	1.12623030168869	0.00311079344417173	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate;miRTarBase;MirTarget	-0.283914984941982	0.000205401464504848		NA	NA	NA
hsa-miR-26b-5p	KAT2B	0.314414148564179	0.461628303578321	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate	-0.209325616874561	0.00228146654038357		NA	NA	NA
hsa-miR-32-5p	KAT2B	2.93035124381469	5.00149131394151e-10	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate;miRTarBase;MirTarget	-0.171341559939028	0.00439435492732836		NA	NA	NA
hsa-miR-330-3p	KAT2B	2.49094236945806	0.000129367003214715	-1.07154210738308	0.0359102937350788	MirTarget	-0.125395845869616	0.00460598972250111		NA	NA	NA
hsa-miR-590-3p	KAT2B	2.35429565068338	2.79601879608564e-06	-1.07154210738308	0.0359102937350788	MirTarget;miRanda;mirMAP;miRNATAP	-0.201255989095611	0.000402275289825389		NA	NA	NA
hsa-miR-590-5p	KAT2B	1.51400888103768	0.0023888567923017	-1.07154210738308	0.0359102937350788	miRanda	-0.27523951564322	1.66081271873843e-06		NA	NA	NA
hsa-miR-92a-3p	KAT2B	1.87892405805529	1.27013821556583e-05	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate;MirTarget	-0.329547501424148	6.41322035707914e-07		NA	NA	NA
hsa-miR-92b-3p	KAT2B	1.69303761469782	0.0103484911955574	-1.07154210738308	0.0359102937350788	MirTarget	-0.174799674751907	5.77797480278543e-05		NA	NA	NA
hsa-miR-93-5p	KAT2B	2.65964181833033	2.58315947526774e-08	-1.07154210738308	0.0359102937350788	miRNAWalker2_validate;miRTarBase;MirTarget	-0.203740459368956	0.000617355085098025		NA	NA	NA
hsa-miR-590-3p	MAML2	2.35429565068338	2.79601879608564e-06	-0.413168543177993	0.602261229161013	mirMAP	-0.329012438490866	0.000185476095623873		NA	NA	NA
hsa-miR-664a-3p	MAML2	0.249882351950296	0.56171157318348	-0.413168543177993	0.602261229161013	mirMAP	-0.314758778911092	0.00283911746099974		NA	NA	NA
hsa-miR-125a-3p	MAML3	-0.0748960586927341	0.920735897434087	-1.59979875455886	0.0248552031772564	miRanda	-0.252927809967453	2.11536457376188e-06		NA	NA	NA
hsa-miR-326	MAML3	1.76645822596029	0.0367310428720192	-1.59979875455886	0.0248552031772564	miRanda	-0.140448676718517	0.00349916515744075		NA	NA	NA
hsa-miR-330-5p	MAML3	2.25110496739954	0.000275527655397415	-1.59979875455886	0.0248552031772564	miRanda	-0.286473663216017	8.60576485915132e-06		NA	NA	NA
hsa-miR-339-5p	MAML3	1.23326828594484	0.0307501214818698	-1.59979875455886	0.0248552031772564	miRanda	-0.3660733529571	1.67011398335008e-07		NA	NA	NA
hsa-miR-590-3p	MAML3	2.35429565068338	2.79601879608564e-06	-1.59979875455886	0.0248552031772564	miRanda	-0.331634784812528	2.83615732688888e-05		NA	NA	NA
hsa-miR-219a-5p	MFNG	0.993473018224215	0.125519257191974	-2.28753805953711	0.000247519034616928	MirTarget	-0.20432002158981	0.00026158382882122		NA	NA	NA
hsa-miR-3607-3p	NCOR2	1.38015131722213	0.0240067155694847	-0.147082422773159	0.633615987388331	miRNATAP	-0.129236071000213	4.18669855142655e-06		NA	NA	NA
hsa-miR-129-5p	NOTCH1	-2.66843722411409	0.00695783358331245	0.769690137962651	0.220066774948586	miRNAWalker2_validate	-0.110371326084891	0.00232253449431888		NA	NA	NA
hsa-miR-200b-3p	NOTCH1	5.56167217794639	6.43540045061709e-16	0.769690137962651	0.220066774948586	MirTarget;TargetScan	-0.128510800873159	0.00896650356017729	26012256;23430952	Nobiletin inhibited hypoxia induced epithelial mesenchymal transition of lung cancer cells by inactivating of Notch 1 signaling and switching on miR 200b; Our findings suggest that downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis	;	lung cancer;sarcoma
hsa-miR-28-5p	NOTCH1	-0.815636722979196	0.0221199948901761	0.769690137962651	0.220066774948586	miRanda	-0.296325329918512	0.00345365385087571		NA	NA	NA
hsa-miR-30a-5p	NOTCH1	-0.768430903969183	0.320487552854215	0.769690137962651	0.220066774948586	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.204280293555659	7.12369623434561e-06		NA	NA	NA
hsa-miR-326	NOTCH1	1.76645822596029	0.0367310428720192	0.769690137962651	0.220066774948586	miRNAWalker2_validate;miRTarBase	-0.125554557582319	0.00291896959861709		NA	NA	NA
hsa-miR-34a-5p	NOTCH1	0.830377770217786	0.0477544831885907	0.769690137962651	0.220066774948586	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.232172466836467	0.00672573934974206	20351093;22438124;23140286;24349627;24565525;25783790;27082152;23642368;22347519;23430952;23902763;21743299;22992310;23145211;25623761;23085450	MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1	drug resistance;;;;cell migration;staging;metastasis;;differentiation;drug resistance;;;;;;;;drug resistance	cervical and endocervical cancer;lung squamous cell cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;breast cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;glioblastoma;colon cancer;prostate cancer;breast cancer;breast cancer
hsa-miR-429	NOTCH1	6.39965293994036	1.96920201593608e-18	0.769690137962651	0.220066774948586	MirTarget;PITA;miRanda;miRNATAP	-0.123045513294408	0.00730512228976083		NA	NA	NA
hsa-miR-582-5p	NOTCH1	0.685177900016753	0.447761540297692	0.769690137962651	0.220066774948586	PITA;miRNATAP	-0.105502291679691	0.0073527830487362		NA	NA	NA
hsa-miR-92b-3p	NOTCH1	1.69303761469782	0.0103484911955574	0.769690137962651	0.220066774948586	miRNATAP	-0.284108256565684	7.34752569192484e-08		NA	NA	NA
hsa-miR-125a-5p	NOTCH2	-1.32352790615388	0.00714301627309467	-0.183005214639284	0.701542660353885	miRanda	-0.193698044396288	0.000406546208769408		NA	NA	NA
hsa-miR-1287-5p	NOTCH2	0.020198871519483	0.975605947457309	-0.183005214639284	0.701542660353885	MirTarget	-0.185636029893122	4.62786960353465e-06		NA	NA	NA
hsa-miR-130a-5p	NOTCH2	1.58028512890005	0.024346333013728	-0.183005214639284	0.701542660353885	mirMAP	-0.132837715500899	0.000646781313089828		NA	NA	NA
hsa-miR-15b-5p	NOTCH2	3.32329949959268	8.40210501034588e-13	-0.183005214639284	0.701542660353885	MirTarget	-0.159555953544984	0.0045875298736748		NA	NA	NA
hsa-miR-16-5p	NOTCH2	2.93575808220754	2.15436817162977e-10	-0.183005214639284	0.701542660353885	miRNAWalker2_validate;MirTarget	-0.200320992954935	0.000425956137379177		NA	NA	NA
hsa-miR-17-5p	NOTCH2	2.3269271449522	2.13987445663942e-05	-0.183005214639284	0.701542660353885	miRNAWalker2_validate	-0.169529439302839	0.00049735138887776		NA	NA	NA
hsa-miR-181b-5p	NOTCH2	1.11397227523501	0.0273417050354018	-0.183005214639284	0.701542660353885	MirTarget;mirMAP	-0.16247047762051	0.00243649018435159		NA	NA	NA
hsa-miR-18a-3p	NOTCH2	3.64944956993027	7.20156641833731e-07	-0.183005214639284	0.701542660353885	MirTarget	-0.129568899948815	0.000325258097347774		NA	NA	NA
hsa-miR-25-3p	NOTCH2	1.12623030168869	0.00311079344417173	-0.183005214639284	0.701542660353885	miRNAWalker2_validate	-0.227988142365454	0.00141552162092909		NA	NA	NA
hsa-miR-29b-3p	NOTCH2	0.666547117072858	0.234055379278093	-0.183005214639284	0.701542660353885	MirTarget	-0.129692383789341	0.00738306358210304		NA	NA	NA
hsa-miR-30b-5p	NOTCH2	0.0238659735605804	0.953223658270319	-0.183005214639284	0.701542660353885	mirMAP	-0.336827698747	3.83284637794388e-07		NA	NA	NA
hsa-miR-423-5p	NOTCH2	0.227366878624794	0.5653498335202	-0.183005214639284	0.701542660353885	MirTarget	-0.222039895627339	0.00132742633847468		NA	NA	NA
hsa-miR-590-3p	NOTCH2	2.35429565068338	2.79601879608564e-06	-0.183005214639284	0.701542660353885	miRanda	-0.179230248536852	0.000723167200406355		NA	NA	NA
hsa-miR-590-5p	NOTCH2	1.51400888103768	0.0023888567923017	-0.183005214639284	0.701542660353885	miRanda	-0.170357474195375	0.0016299088847882		NA	NA	NA
hsa-miR-7-1-3p	NOTCH2	1.43074343339835	0.00471215970502094	-0.183005214639284	0.701542660353885	MirTarget;mirMAP	-0.188530173299219	0.00039076714007433		NA	NA	NA
hsa-miR-92a-3p	NOTCH2	1.87892405805529	1.27013821556583e-05	-0.183005214639284	0.701542660353885	miRNAWalker2_validate	-0.198240648839897	0.00148511169695724		NA	NA	NA
hsa-miR-200a-3p	NOTCH3	6.336081120041	4.024313571871e-16	0.618860145042115	0.396379833565062	mirMAP	-0.216278824952196	1.48667818246519e-05		NA	NA	NA
hsa-miR-335-5p	NOTCH3	0.167216045757305	0.803897055331049	0.618860145042115	0.396379833565062	miRNAWalker2_validate	-0.295997976809513	1.0884314636059e-06		NA	NA	NA
hsa-miR-491-5p	NOTCH3	0.569358547192776	0.313310594748302	0.618860145042115	0.396379833565062	MirTarget;miRanda	-0.251084112574464	0.000740410007629053		NA	NA	NA
hsa-miR-18a-3p	NOTCH4	3.64944956993027	7.20156641833731e-07	-2.46437154312364	6.51540838817574e-06	miRNAWalker2_validate	-0.119579660250972	0.00453986130649794		NA	NA	NA
hsa-miR-193a-3p	NOTCH4	0.646392169474854	0.207134343676122	-2.46437154312364	6.51540838817574e-06	miRanda	-0.217389609005187	0.000404498505803192		NA	NA	NA
hsa-miR-330-5p	NOTCH4	2.25110496739954	0.000275527655397415	-2.46437154312364	6.51540838817574e-06	miRanda	-0.251461886416884	4.16511414348063e-07		NA	NA	NA
hsa-miR-429	NOTCH4	6.39965293994036	1.96920201593608e-18	-2.46437154312364	6.51540838817574e-06	miRNATAP	-0.153317961674764	0.000141856698170077		NA	NA	NA
hsa-miR-374b-5p	NUMB	-0.114749866169918	0.764888930049438	-0.129801201004472	0.608140635212593	miRNATAP	-0.125044124096626	0.000865155314600044		NA	NA	NA
hsa-miR-194-3p	NUMBL	1.91743783341496	0.105383373371284	-1.49645482578135	0.000907444293137311	MirTarget	-0.141133199180767	2.73380514554449e-11		NA	NA	NA
hsa-miR-186-5p	PSEN1	0.445443449112564	0.185447310527704	0.368661147327623	0.170605556176267	mirMAP	-0.185745049339955	4.75468410670268e-05		NA	NA	NA
hsa-miR-429	PSEN2	6.39965293994036	1.96920201593608e-18	-1.00805326438267	0.0797582414775788	miRNATAP	-0.119101882066447	0.00462832458751878		NA	NA	NA