miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-142-3p CDC6 -1.4243101967815 1.92609481097765e-14 3.43409755895777 3.54117234711163e-45 miRNAWalker2_validate -0.209613186749947 0.00240261531698926 NA NA NA hsa-miR-193b-3p CDC6 -0.166697207281748 0.272022543069482 3.43409755895777 3.54117234711163e-45 miRNAWalker2_validate -0.176316049425455 0.0451899414998656 NA NA NA hsa-miR-199a-5p CDC6 -1.98848462405923 2.0421622713753e-11 3.43409755895777 3.54117234711163e-45 miRanda -0.267112671827499 4.32680677860271e-10 NA NA NA hsa-miR-26a-5p CDC6 -0.963792031426845 1.83360999387345e-22 3.43409755895777 3.54117234711163e-45 miRNAWalker2_validate -0.792267027675385 3.38263043470135e-10 25100863;27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis ; lung cancer;ovarian cancer hsa-miR-3607-3p CDC6 -2.15518588554493 1.03390728226728e-23 3.43409755895777 3.54117234711163e-45 mirMAP -0.421624410789328 1.12661397039956e-13 NA NA NA hsa-miR-101-3p CDC7 -1.48176407980989 3.98950707385704e-31 2.01751950910415 4.47781393592943e-28 miRNAWalker2_validate -0.618519649455716 1.77004294891154e-20 NA NA NA hsa-miR-126-5p CDC7 -0.428561469405594 6.6035585844222e-05 2.01751950910415 4.47781393592943e-28 mirMAP -0.394449488088942 8.64621091696843e-06 NA NA NA hsa-miR-192-5p CDC7 -0.50188499512787 0.00344713341196035 2.01751950910415 4.47781393592943e-28 miRNAWalker2_validate -0.19830872980512 0.000359320910618898 NA NA NA hsa-miR-199a-5p CDC7 -1.98848462405923 2.0421622713753e-11 2.01751950910415 4.47781393592943e-28 MirTarget;miRanda -0.111439193657119 0.000381838786294689 NA NA NA hsa-miR-215-5p CDC7 -0.981544773246509 3.14452272477156e-05 2.01751950910415 4.47781393592943e-28 miRNAWalker2_validate -0.107716575020922 0.00749268034794886 NA NA NA hsa-miR-3065-3p CDC7 -1.04244468016704 4.60743424372577e-05 2.01751950910415 4.47781393592943e-28 MirTarget -0.125795095836249 0.000681186625781064 NA NA NA hsa-miR-335-5p CDC7 -1.61347836513558 1.62757083289711e-19 2.01751950910415 4.47781393592943e-28 MirTarget -0.183857935379035 0.000324011220012664 NA NA NA hsa-miR-3607-3p CDC7 -2.15518588554493 1.03390728226728e-23 2.01751950910415 4.47781393592943e-28 miRNATAP -0.281769617963819 7.78721407023138e-12 NA NA NA hsa-miR-455-5p CDC7 -0.270546034117157 0.0581320703577731 2.01751950910415 4.47781393592943e-28 miRanda -0.141288330591948 0.0362291855247305 NA NA NA hsa-miR-195-3p DBF4 -1.09375690196245 4.70092324819807e-09 0.924895042673626 1.9008434964275e-15 mirMAP -0.122761280981961 7.99493049317741e-05 NA NA NA hsa-miR-30a-5p DBF4 -0.626257932887855 0.000108198196973765 0.924895042673626 1.9008434964275e-15 MirTarget -0.233029013858222 4.14759152817446e-11 NA NA NA hsa-miR-30b-5p DBF4 -0.54056186708617 2.44688760798341e-05 0.924895042673626 1.9008434964275e-15 MirTarget -0.115375084345556 0.011497459671902 NA NA NA hsa-miR-30e-5p DBF4 -0.627815042856657 3.02205690184908e-10 0.924895042673626 1.9008434964275e-15 MirTarget -0.167793410853246 0.00390640864782242 NA NA NA hsa-miR-3607-3p DBF4 -2.15518588554493 1.03390728226728e-23 0.924895042673626 1.9008434964275e-15 MirTarget;miRNATAP -0.157207609296571 5.40688898105347e-10 NA NA NA hsa-miR-542-3p DBF4 -1.31351015149842 3.64642423288576e-22 0.924895042673626 1.9008434964275e-15 miRanda -0.13261216933844 0.00124728512837269 NA NA NA hsa-miR-126-5p MCM10 -0.428561469405594 6.6035585844222e-05 3.44644537200841 1.46743341445993e-36 mirMAP -0.822766656720111 6.72405996964779e-10 NA NA NA hsa-miR-192-5p MCM10 -0.50188499512787 0.00344713341196035 3.44644537200841 1.46743341445993e-36 miRNAWalker2_validate -0.205997953722998 0.0151367215753814 NA NA NA hsa-miR-199a-5p MCM10 -1.98848462405923 2.0421622713753e-11 3.44644537200841 1.46743341445993e-36 miRanda -0.26098547695023 3.1433514813163e-08 NA NA NA hsa-miR-215-5p MCM10 -0.981544773246509 3.14452272477156e-05 3.44644537200841 1.46743341445993e-36 miRNAWalker2_validate -0.15731858222731 0.0101978997891122 NA NA NA hsa-miR-326 MCM10 -1.881935132554 1.68087316863775e-21 3.44644537200841 1.46743341445993e-36 miRanda -0.254845923030098 0.000300527463616244 NA NA NA hsa-miR-139-5p MCM2 -2.11299531796557 8.16407076415038e-28 2.386213124759 2.3135357405317e-32 miRanda -0.60342281675185 7.72277609982919e-38 NA NA NA hsa-miR-192-5p MCM3 -0.50188499512787 0.00344713341196035 1.38245898490982 6.59458276841991e-26 miRNAWalker2_validate -0.118151752469436 0.00283190558585697 NA NA NA hsa-miR-193b-3p MCM3 -0.166697207281748 0.272022543069482 1.38245898490982 6.59458276841991e-26 miRNAWalker2_validate -0.109666320711668 0.0150001333224802 NA NA NA hsa-miR-26b-5p MCM3 -1.10804856399744 4.14176110314282e-22 1.38245898490982 6.59458276841991e-26 miRNAWalker2_validate -0.337133110078096 1.47085794375846e-09 NA NA NA hsa-miR-450b-5p MCM3 -1.34333360369432 2.68386079790462e-17 1.38245898490982 6.59458276841991e-26 miRNATAP -0.217971388429723 8.89582939084555e-08 NA NA NA hsa-let-7b-5p MCM4 -0.959013717270803 5.95127281258643e-11 1.32614408881812 5.23855543390612e-15 miRNAWalker2_validate -0.127824287587723 0.025555024739509 NA NA NA hsa-miR-193b-3p MCM4 -0.166697207281748 0.272022543069482 1.32614408881812 5.23855543390612e-15 miRNAWalker2_validate -0.135153823192416 0.0169645669650306 NA NA NA hsa-miR-486-5p MCM4 -1.77766890600022 2.9071717929922e-14 1.32614408881812 5.23855543390612e-15 miRanda -0.135110848198039 0.000125083316969585 NA NA NA hsa-miR-542-3p MCM5 -1.31351015149842 3.64642423288576e-22 1.34044307943415 2.17000754715776e-22 miRanda -0.279862800712507 1.04514523632503e-08 NA NA NA hsa-miR-192-5p MCM6 -0.50188499512787 0.00344713341196035 1.68713872113643 5.47744551594301e-30 miRNAWalker2_validate -0.129535871289776 0.00415957553139546 NA NA NA hsa-miR-30c-1-3p MCM6 -1.39373825444537 6.39912952911454e-17 1.68713872113643 5.47744551594301e-30 MirTarget -0.128319123277048 0.00481540286180515 NA NA NA hsa-miR-30c-2-3p MCM6 -1.39811819128587 3.66376924527665e-15 1.68713872113643 5.47744551594301e-30 MirTarget -0.269887567350998 7.24016535492575e-11 NA NA NA hsa-let-7b-5p MCM7 -0.959013717270803 5.95127281258643e-11 1.28544451959494 2.38346141988918e-22 miRNAWalker2_validate -0.247616423212068 3.20929332495545e-08 NA NA NA hsa-miR-99a-5p MCM8 -1.51481656384839 3.93230057259529e-14 1.26713752120723 4.49769252025548e-15 miRNAWalker2_validate -0.216656612997587 2.48024203127108e-08 NA NA NA hsa-miR-24-3p PCNA -0.257825594021966 0.00689742600215061 0.966521187541277 2.13251268175503e-18 miRNAWalker2_validate -0.174598229125149 0.00323913466605276 NA NA NA hsa-miR-26b-5p PCNA -1.10804856399744 4.14176110314282e-22 0.966521187541277 2.13251268175503e-18 miRNAWalker2_validate -0.274512184414973 2.31662573425547e-09 NA NA NA hsa-miR-30a-5p PCNA -0.626257932887855 0.000108198196973765 0.966521187541277 2.13251268175503e-18 miRNAWalker2_validate -0.140104186770926 4.44986190016326e-05 NA NA NA hsa-miR-542-3p PCNA -1.31351015149842 3.64642423288576e-22 0.966521187541277 2.13251268175503e-18 miRanda;miRNATAP -0.256334358356727 2.8017131374182e-11 NA NA NA hsa-miR-26b-5p POLA1 -1.10804856399744 4.14176110314282e-22 0.83204915146344 3.99573648408038e-13 miRNAWalker2_validate -0.202720926566387 2.00980125176476e-05 NA NA NA hsa-let-7b-5p POLD2 -0.959013717270803 5.95127281258643e-11 -0.0956910482206927 0.351453134850314 miRNAWalker2_validate -0.124926174858705 0.000167953905984256 NA NA NA hsa-miR-107 POLD3 0.241662461253461 0.0170788899505389 0.489732850996236 9.40514076531329e-07 MirTarget;miRanda -0.105552398759391 0.0312652394471409 NA NA NA hsa-miR-29a-3p POLD3 -0.856762511178136 4.65330336378459e-12 0.489732850996236 9.40514076531329e-07 miRNAWalker2_validate -0.265582943515243 2.42413104230049e-12 NA NA NA hsa-miR-125a-3p POLD4 -0.841683158494395 3.51202687176603e-05 -0.0608055722632077 0.631576455395915 miRanda -0.101635571711945 0.000922048219940505 NA NA NA hsa-miR-335-5p POLD4 -1.61347836513558 1.62757083289711e-19 -0.0608055722632077 0.631576455395915 miRNAWalker2_validate -0.142405351726657 1.37620685221773e-05 NA NA NA hsa-miR-590-5p POLD4 -0.103355559980404 0.310027295317092 -0.0608055722632077 0.631576455395915 miRanda -0.141118926246061 0.0212970735299828 NA NA NA hsa-miR-29a-3p POLE3 -0.856762511178136 4.65330336378459e-12 0.200584684295309 0.00379024799229057 MirTarget -0.138938362619582 1.22784538454998e-07 NA NA NA hsa-miR-29c-3p POLE3 -1.4367517608807 1.61767774905781e-21 0.200584684295309 0.00379024799229057 MirTarget -0.144999424635814 2.64314383257237e-12 NA NA NA hsa-let-7b-5p PRIM1 -0.959013717270803 5.95127281258643e-11 1.30250431119332 1.7051401321804e-14 miRNAWalker2_validate -0.303357872305665 7.6487451406738e-08 NA NA NA hsa-miR-125a-3p PRIM1 -0.841683158494395 3.51202687176603e-05 1.30250431119332 1.7051401321804e-14 miRanda -0.133621860769323 0.00170693157731592 NA NA NA hsa-miR-24-3p PRIM1 -0.257825594021966 0.00689742600215061 1.30250431119332 1.7051401321804e-14 miRNAWalker2_validate -0.261423093470599 0.00382532559062354 NA NA NA hsa-miR-30a-5p PRIM1 -0.626257932887855 0.000108198196973765 1.30250431119332 1.7051401321804e-14 miRNAWalker2_validate -0.341128128286466 3.35917756865935e-11 NA NA NA hsa-miR-326 PRIM2 -1.881935132554 1.68087316863775e-21 1.37170010880349 2.57610616926506e-33 miRanda -0.148947222816366 2.62023542106901e-07 NA NA NA hsa-miR-542-3p PRIM2 -1.31351015149842 3.64642423288576e-22 1.37170010880349 2.57610616926506e-33 MirTarget;miRanda -0.281661231666077 9.10545570927775e-12 NA NA NA hsa-miR-342-3p RFC1 -0.319677314984262 0.0449813878317147 0.439276603294255 1.89825778838383e-07 miRanda -0.151436400670624 3.57787786978285e-09 NA NA NA hsa-miR-450b-5p RFC1 -1.34333360369432 2.68386079790462e-17 0.439276603294255 1.89825778838383e-07 MirTarget;PITA -0.146621843950816 3.15092104434682e-09 NA NA NA hsa-let-7a-3p RFC3 -0.568717557554068 1.00947202557819e-07 0.962948004313737 3.30946957694076e-14 MirTarget -0.174105313327648 0.00333748336519782 NA NA NA hsa-let-7b-3p RFC3 -1.21979213547786 5.84575581584603e-17 0.962948004313737 3.30946957694076e-14 MirTarget -0.175494386061067 2.88111957398962e-05 NA NA NA hsa-let-7f-1-3p RFC3 -0.704017923073338 7.84883628944999e-07 0.962948004313737 3.30946957694076e-14 MirTarget -0.147251837023958 0.00103105421032342 NA NA NA hsa-miR-139-5p RFC3 -2.11299531796557 8.16407076415038e-28 0.962948004313737 3.30946957694076e-14 miRanda -0.175133367532129 8.25050875678443e-09 NA NA NA hsa-miR-181c-5p RFC3 -0.00639394152050299 0.969127212255928 0.962948004313737 3.30946957694076e-14 MirTarget -0.10313609765237 0.00781329434531289 NA NA NA hsa-miR-125b-5p RFC5 -1.35767721102906 1.16564617395164e-18 0.429581220768429 2.35499720623724e-05 MirTarget -0.182847900533476 2.08642986044577e-09 NA NA NA hsa-miR-140-5p RFC5 -0.220106443070144 0.0140713197101242 0.429581220768429 2.35499720623724e-05 miRanda -0.11675585850606 0.0383418480233544 NA NA NA hsa-miR-126-5p RPA1 -0.428561469405594 6.6035585844222e-05 0.0999852338806626 0.179641789826618 mirMAP -0.134732214096414 5.61439976348028e-05 NA NA NA hsa-miR-139-5p RPS27A -2.11299531796557 8.16407076415038e-28 0.317404543049338 0.006769012872385 miRanda -0.149797165024945 3.9685784460762e-08 NA NA NA hsa-miR-140-5p RPS27A -0.220106443070144 0.0140713197101242 0.317404543049338 0.006769012872385 miRanda -0.24539080127799 0.000135017289145289 NA NA NA hsa-miR-26a-5p RPS27A -0.963792031426845 1.83360999387345e-22 0.317404543049338 0.006769012872385 miRNAWalker2_validate -0.180199832960546 0.00110557437275453 NA NA NA hsa-miR-30c-5p RPS27A -0.432111642767632 0.000159764714931007 0.317404543049338 0.006769012872385 miRNAWalker2_validate -0.117131976788904 0.0192292132325846 NA NA NA hsa-miR-139-5p TOP2A -2.11299531796557 8.16407076415038e-28 4.1548998577835 1.29817805633082e-49 miRanda -0.962231267816668 3.62861978228759e-47 26079880 We identified that miR-139 a previous reported anti-metastatic microRNA targets 3'-untranslated region 3'UTR of TOP2a mRNA; Further more we revealed that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels; And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139 breast cancer hsa-miR-193b-3p TOP2A -0.166697207281748 0.272022543069482 4.1548998577835 1.29817805633082e-49 miRNAWalker2_validate -0.212595608489824 0.0382253945734576 NA NA NA hsa-miR-542-3p TOP2A -1.31351015149842 3.64642423288576e-22 4.1548998577835 1.29817805633082e-49 miRanda -0.728215652594189 6.62436701151958e-12 NA NA NA hsa-let-7c-5p UBA52 -1.70744661345097 2.87934212005942e-20 0.28393248928586 0.0110134022626622 miRNAWalker2_validate -0.106594975606236 0.000134675405654401 NA NA NA hsa-miR-140-5p UBA52 -0.220106443070144 0.0140713197101242 0.28393248928586 0.0110134022626622 miRanda -0.183687683086808 0.00278067605833624 NA NA NA hsa-miR-542-3p UBA52 -1.31351015149842 3.64642423288576e-22 0.28393248928586 0.0110134022626622 miRanda -0.12412810050612 0.00112681118866719 NA NA NA hsa-miR-590-3p UBA52 -0.473167498047808 1.76652934637227e-05 0.28393248928586 0.0110134022626622 miRanda;mirMAP -0.196166124967999 6.39722391506686e-05 NA NA NA hsa-miR-148b-5p UBB 0.295777213389605 0.0255749859535438 -0.538601985573999 4.76332158900571e-08 miRNAWalker2_validate -0.103969780962462 0.00487704720668222 NA NA NA hsa-miR-181b-5p UBB 0.488256489401108 0.00105321129419701 -0.538601985573999 4.76332158900571e-08 miRNAWalker2_validate -0.194003959275969 1.4466728714083e-09 NA NA NA