miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p AIFM1 0.133031570393829 0.651804468011451 0.0805957455079636 0.684922297405041 miRNATAP -0.143838091179269 0.00399422135609107 NA NA NA hsa-let-7i-5p AIFM1 -0.192757304271016 0.477339948491839 0.0805957455079636 0.684922297405041 miRNATAP -0.207099843844489 0.000129544633297414 NA NA NA hsa-miR-125a-5p AIFM1 -0.306104092733909 0.370798466662369 0.0805957455079636 0.684922297405041 miRanda -0.114699318132068 0.00731017492153802 NA NA NA hsa-miR-125b-5p AIFM1 0.3966978923849 0.254597980570568 0.0805957455079636 0.684922297405041 miRNATAP -0.153398578583003 0.000224173636320477 NA NA NA hsa-miR-145-5p AIFM1 -1.16412248555193 0.00337114382854581 0.0805957455079636 0.684922297405041 miRNATAP -0.0791602225017502 0.0294221941965003 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-155-5p AIFM1 -1.43184489211345 0.00780837893756083 0.0805957455079636 0.684922297405041 miRNAWalker2_validate -0.0833535176024029 0.00165010576632472 NA NA NA hsa-miR-199a-5p AIFM1 -0.208670149801867 0.635984251700429 0.0805957455079636 0.684922297405041 miRanda -0.174938778747708 4.14788688834454e-08 NA NA NA hsa-miR-125b-5p AKT1 0.3966978923849 0.254597980570568 0.0411121325128558 0.7924953410872 miRNAWalker2_validate;miRTarBase -0.114909987932531 0.000401208777358222 NA NA NA hsa-miR-22-3p AKT2 0.0163846581484712 0.940293651037259 -0.149197168223703 0.465705117353827 mirMAP -0.148177705588583 0.0386525259523355 NA NA NA hsa-miR-326 AKT2 -0.753790048650868 0.139469657871132 -0.149197168223703 0.465705117353827 miRanda -0.062272566858839 0.0337818534318825 NA NA NA hsa-miR-106b-5p AKT3 -0.814181559290382 0.00942928404699138 -0.529175072565548 0.251564596095872 miRNATAP -0.540610793573058 3.92705273857721e-07 NA NA NA hsa-miR-17-3p AKT3 -0.0709436934154812 0.786428153888425 -0.529175072565548 0.251564596095872 miRNATAP -0.518942347374833 8.71382609534566e-05 NA NA NA hsa-miR-17-5p AKT3 -0.667512721923102 0.0423050196597589 -0.529175072565548 0.251564596095872 TargetScan;miRNATAP -0.467042481537406 5.19537791624785e-06 NA NA NA hsa-miR-181b-5p AKT3 0.253272120717567 0.563522710157574 -0.529175072565548 0.251564596095872 miRNATAP -0.161671835767337 0.0386637231847417 NA NA NA hsa-miR-20a-5p AKT3 -0.39483820331792 0.269587643143535 -0.529175072565548 0.251564596095872 miRNATAP -0.469105608003424 5.53690522863139e-07 NA NA NA hsa-miR-29a-3p AKT3 -0.387866348913471 0.226645201041662 -0.529175072565548 0.251564596095872 miRNATAP -0.355090864409352 0.000901502417277479 NA NA NA hsa-miR-29b-3p AKT3 -0.392267406583841 0.343581862655996 -0.529175072565548 0.251564596095872 miRNATAP -0.266301156801006 0.00118643910713777 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.133603914094895 0.743610228811317 -0.529175072565548 0.251564596095872 miRNAWalker2_validate;miRNATAP -0.173103859521199 0.039638521732677 NA NA NA hsa-miR-335-3p AKT3 -0.496550554602651 0.223248314670008 -0.529175072565548 0.251564596095872 mirMAP -0.301184296417177 0.000290449477592031 NA NA NA hsa-miR-362-3p AKT3 -1.20829972287608 0.012574092123476 -0.529175072565548 0.251564596095872 miRanda -0.266533591110592 0.000130107083252102 NA NA NA hsa-miR-362-5p AKT3 -0.73199764539445 0.112060703377193 -0.529175072565548 0.251564596095872 PITA;TargetScan;miRNATAP -0.296720501008939 4.65405125702701e-05 NA NA NA hsa-miR-374b-5p AKT3 -0.936361879691007 0.00140373477346958 -0.529175072565548 0.251564596095872 mirMAP -0.263333212013726 0.0245883041256715 NA NA NA hsa-miR-502-3p AKT3 -0.727559828010508 0.036178842243285 -0.529175072565548 0.251564596095872 miRNATAP -0.345920204099336 0.000406671140432544 NA NA NA hsa-miR-502-5p AKT3 -1.02459788331767 0.0394885127403471 -0.529175072565548 0.251564596095872 PITA;miRNATAP -0.237566618683461 0.000530094992575979 NA NA NA hsa-miR-505-3p AKT3 -1.26213025194883 0.000261636321419412 -0.529175072565548 0.251564596095872 mirMAP -0.258525669572278 0.00822013383141933 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-577 AKT3 0.810246698380877 0.314263384393584 -0.529175072565548 0.251564596095872 mirMAP -0.153248899688928 0.00024019858050482 NA NA NA hsa-miR-93-5p AKT3 -0.468459476414832 0.131463449813313 -0.529175072565548 0.251564596095872 miRNATAP -0.564024939229822 1.83376229945027e-07 NA NA NA hsa-miR-18a-5p ATM -1.17872230313757 0.0043629711019433 -0.782008167965449 0.0427504884792423 miRNAWalker2_validate;miRTarBase;MirTarget -0.148749521553414 0.0307588662112835 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-203a-3p ATM 1.97571040954712 0.0326593804470764 -0.782008167965449 0.0427504884792423 MirTarget -0.0803822018892808 0.00835275014338235 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-455-5p ATM -0.230512086486246 0.540435117714922 -0.782008167965449 0.0427504884792423 miRanda -0.299882670669308 7.14173705155653e-05 NA NA NA hsa-miR-127-3p BAD -0.0349437841134108 0.944205560394057 0.340277665920826 0.322735489522388 miRanda;miRNATAP -0.177135787486031 0.000436903579682028 NA NA NA hsa-miR-326 BAD -0.753790048650868 0.139469657871132 0.340277665920826 0.322735489522388 miRanda -0.245016812231989 4.12358801236773e-07 NA NA NA hsa-miR-30a-5p BAX -0.588553206289925 0.175311638663077 -0.0369352298141683 0.885346604739766 miRNAWalker2_validate -0.0875502096813265 0.0437699220646026 NA NA NA hsa-miR-15b-3p BCL2 -0.789337612611649 0.0578523080484409 -1.62850021511731 0.00260918153342021 mirMAP -0.190954430568302 0.049984718021194 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-2-3p BCL2 -1.02821208937232 0.00734958396812714 -1.62850021511731 0.00260918153342021 mirMAP -0.22273405966581 0.0344985917064739 NA NA NA hsa-miR-17-5p BCL2 -0.667512721923102 0.0423050196597589 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase -0.288279172010406 0.0201613010540067 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-182-5p BCL2 0.193824666419893 0.730295924168823 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase;mirMAP -0.404807248319988 4.5267413951865e-09 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-192-5p BCL2 2.0972919255143 0.00232678828970491 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate -0.307261009177571 3.69254322154122e-08 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 1.32792171126529 0.198066738241767 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate -0.127488285971649 0.000971149801297516 NA NA NA hsa-miR-200a-5p BCL2 2.64896699149716 1.30695788228742e-05 -1.62850021511731 0.00260918153342021 mirMAP -0.366028633592665 3.90470191610824e-09 NA NA NA hsa-miR-200b-3p BCL2 1.84496256556404 0.00297111610556856 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.458635967572279 1.54761671828128e-14 NA NA NA hsa-miR-200b-5p BCL2 0.86104461173291 0.183273431475269 -1.62850021511731 0.00260918153342021 mirMAP -0.459233437114279 1.54335069820163e-11 NA NA NA hsa-miR-200c-3p BCL2 1.55610325614114 0.0126526013557324 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase;mirMAP -0.400674906891086 4.57309382001565e-11 NA NA NA hsa-miR-20a-5p BCL2 -0.39483820331792 0.269587643143535 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase -0.290519296474077 0.0107643537390206 NA NA NA hsa-miR-215-5p BCL2 3.0713645183039 0.00157974555130209 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate -0.111537773252076 0.00607094895027733 NA NA NA hsa-miR-224-5p BCL2 -0.272705922198226 0.694358594064224 -1.62850021511731 0.00260918153342021 mirMAP -0.186422897486596 0.00121272915253227 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-29a-5p BCL2 -0.598913843551928 0.0664324113687381 -1.62850021511731 0.00260918153342021 mirMAP -0.250986605255296 0.045390841499406 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 -0.392267406583841 0.343581862655996 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase -0.214127362109822 0.0291196847778623 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 0.744542127327022 0.29683696958743 -1.62850021511731 0.00260918153342021 mirMAP -0.120716302621566 0.0322966878427689 NA NA NA hsa-miR-33a-5p BCL2 -0.993826765770883 0.0645799435927515 -1.62850021511731 0.00260918153342021 mirMAP -0.243132490838964 0.00109550665191926 NA NA NA hsa-miR-33b-5p BCL2 0.621849465135339 0.329304820187453 -1.62850021511731 0.00260918153342021 miRTarBase;mirMAP -0.192544358775032 0.00291149203130561 NA NA NA hsa-miR-34a-5p BCL2 -0.243748387753732 0.416958179815378 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase -0.398870676754929 0.00349512956149982 19714243;24565525;23155233;24444609;20687223;22623155;24988056;18803879;25053345;20433755;21399894;22964582;23862748 Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression poor survival;drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;drug resistance;;;; pancreatic cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-429 BCL2 1.86385884044684 0.00726080911989418 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.404161742946206 4.66831994615036e-14 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-455-5p BCL2 -0.230512086486246 0.540435117714922 -1.62850021511731 0.00260918153342021 mirMAP -0.373184988098705 0.000503860013991374 NA NA NA hsa-miR-577 BCL2 0.810246698380877 0.314263384393584 -1.62850021511731 0.00260918153342021 PITA -0.106972772184898 0.032661238068827 NA NA NA hsa-miR-582-5p BCL2 -0.241398739931134 0.638696591630038 -1.62850021511731 0.00260918153342021 PITA -0.161474407415024 0.0403847032539731 NA NA NA hsa-miR-96-5p BCL2 -0.14300109523641 0.834020197937914 -1.62850021511731 0.00260918153342021 miRNAWalker2_validate;TargetScan -0.426447531570005 7.17485557013877e-15 NA NA NA hsa-let-7g-3p BCL2L1 -0.841943598032208 0.0192258112225686 0.862878551244136 0.00505808349616903 miRNATAP -0.176230700759369 0.00559966077565789 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-140-5p BCL2L1 -1.19629127894344 4.39286577178892e-05 0.862878551244136 0.00505808349616903 PITA;miRanda;miRNATAP -0.307137557662079 6.38250526246617e-05 NA NA NA hsa-miR-185-3p BCL2L1 -0.807260190159478 0.0588027224863732 0.862878551244136 0.00505808349616903 mirMAP;miRNATAP -0.12686180970182 0.0178033074914833 NA NA NA hsa-miR-30b-3p BCL2L1 -0.572694191047113 0.234897503722221 0.862878551244136 0.00505808349616903 MirTarget -0.1425207225079 0.00253471311327568 NA NA NA hsa-miR-326 BCL2L1 -0.753790048650868 0.139469657871132 0.862878551244136 0.00505808349616903 PITA;miRanda;mirMAP;miRNATAP -0.106146869255634 0.0179727838283338 NA NA NA hsa-miR-330-5p BCL2L1 0.647187634039027 0.0863451847130066 0.862878551244136 0.00505808349616903 PITA;miRanda;miRNATAP -0.126466308662134 0.038183466207096 NA NA NA hsa-miR-342-3p BCL2L1 -1.50859606438677 0.000361128404069141 0.862878551244136 0.00505808349616903 PITA;miRanda;miRNATAP -0.188002535163397 0.000379670720967844 NA NA NA hsa-miR-342-5p BCL2L1 -1.67530647772537 6.70484069582523e-05 0.862878551244136 0.00505808349616903 miRNATAP -0.17399197804442 0.00106397597563481 NA NA NA hsa-miR-377-3p BCL2L1 -1.31382052580179 0.0227530245445242 0.862878551244136 0.00505808349616903 MirTarget -0.113312494924217 0.00391025513290396 NA NA NA hsa-miR-421 BCL2L1 -0.177803877528689 0.691941942432956 0.862878551244136 0.00505808349616903 miRanda -0.165039580012262 0.00127774522729687 NA NA NA hsa-miR-484 BCL2L1 -1.1809680559247 5.22769480279927e-05 0.862878551244136 0.00505808349616903 miRNAWalker2_validate -0.194509985105065 0.0127943235345136 NA NA NA hsa-miR-664a-5p BCL2L1 -0.924156484977131 0.0370344103127472 0.862878551244136 0.00505808349616903 mirMAP -0.194838581632391 0.000133778851703404 NA NA NA hsa-miR-137 BID -0.0787835496950151 0.930521869365511 0.0869069315426572 0.771309329992877 miRanda -0.0586693367840888 0.0209269955589588 NA NA NA hsa-miR-370-3p BID -0.694628514848741 0.227212510825184 0.0869069315426572 0.771309329992877 MirTarget -0.125277967789361 0.000914775519275123 NA NA NA hsa-miR-543 BID -1.03495265003894 0.0713462149984802 0.0869069315426572 0.771309329992877 miRanda -0.101553407881287 0.00802257613236637 NA NA NA hsa-miR-29b-3p BIRC2 -0.392267406583841 0.343581862655996 -0.099557046775673 0.592624632456244 MirTarget -0.11468003082094 0.000426087691670102 NA NA NA hsa-miR-29c-3p BIRC2 -0.133603914094895 0.743610228811317 -0.099557046775673 0.592624632456244 MirTarget -0.0909893777802196 0.00625130910926811 NA NA NA hsa-miR-421 BIRC2 -0.177803877528689 0.691941942432956 -0.099557046775673 0.592624632456244 miRanda -0.0636790554612275 0.0374310003007998 NA NA NA hsa-miR-500a-5p BIRC2 -1.10136801235297 0.0179063223236651 -0.099557046775673 0.592624632456244 MirTarget -0.0794321047625876 0.0059757853368617 NA NA NA hsa-miR-129-5p BIRC3 1.01348286569596 0.367116067584743 -0.619507001720162 0.371660989995059 miRanda -0.211752300534459 1.6456028877764e-06 NA NA NA hsa-miR-338-5p BIRC3 0.336440913368409 0.532935762698486 -0.619507001720162 0.371660989995059 mirMAP -0.214982549263711 0.0236083540767304 NA NA NA hsa-miR-369-3p BIRC3 -0.832959746953411 0.173640923390195 -0.619507001720162 0.371660989995059 MirTarget;miRNATAP -0.406718625873776 5.36016948704227e-07 NA NA NA hsa-miR-375 BIRC3 2.45956739868952 0.0171124871214617 -0.619507001720162 0.371660989995059 miRNAWalker2_validate -0.275013128667795 5.33867679774929e-09 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck cancer hsa-miR-496 BIRC3 -0.263423110562247 0.668883492994483 -0.619507001720162 0.371660989995059 mirMAP -0.309736109259521 0.000159233937197285 NA NA NA hsa-miR-577 BIRC3 0.810246698380877 0.314263384393584 -0.619507001720162 0.371660989995059 MirTarget -0.148637747777021 0.0191201513360721 NA NA NA hsa-miR-664a-3p BIRC3 -0.548519235569408 0.0680199398699682 -0.619507001720162 0.371660989995059 mirMAP -0.70579365899732 3.43398363164351e-05 NA NA NA hsa-miR-98-5p BIRC3 -0.2176359368719 0.422768546610498 -0.619507001720162 0.371660989995059 miRNAWalker2_validate -0.999756695708801 1.01030935628028e-07 NA NA NA hsa-miR-140-5p CAPN1 -1.19629127894344 4.39286577178892e-05 0.315326537162736 0.269780173074745 miRanda;miRNATAP -0.240714011758699 0.000701832774794348 NA NA NA hsa-miR-491-5p CAPN1 -0.787801664777276 0.12392872487051 0.315326537162736 0.269780173074745 miRanda -0.125197537896658 0.0022370852967893 NA NA NA hsa-miR-101-3p CAPN2 -0.269552419431912 0.365715352261274 0.823501603105938 0.00458295114193243 miRNAWalker2_validate;MirTarget -0.307429227930511 2.25593889511975e-05 NA NA NA hsa-miR-129-5p CAPN2 1.01348286569596 0.367116067584743 0.823501603105938 0.00458295114193243 miRanda -0.0751749852087964 6.20656912361512e-05 NA NA NA hsa-miR-137 CAPN2 -0.0787835496950151 0.930521869365511 0.823501603105938 0.00458295114193243 MirTarget;PITA;miRanda -0.0839173679607221 0.000692110389135915 NA NA NA hsa-miR-1468-5p CAPN2 -0.366402869107221 0.526782983627538 0.823501603105938 0.00458295114193243 MirTarget -0.182644846363824 4.50809766232456e-07 NA NA NA hsa-miR-421 CAPN2 -0.177803877528689 0.691941942432956 0.823501603105938 0.00458295114193243 miRanda -0.171716551423846 0.000365127039610242 NA NA NA hsa-miR-590-3p CAPN2 -0.921957466414335 0.0345620969748757 0.823501603105938 0.00458295114193243 miRanda -0.152986240831532 0.00182893757547261 NA NA NA hsa-miR-590-5p CAPN2 -0.984421368732497 0.00533663360221062 0.823501603105938 0.00458295114193243 miRanda -0.191339011444324 0.00163029548191987 NA NA NA hsa-miR-7-5p CAPN2 0.818434078643802 0.510587133222615 0.823501603105938 0.00458295114193243 miRNAWalker2_validate -0.098214710973126 3.7793053159455e-07 NA NA NA hsa-miR-125a-5p CASP10 -0.306104092733909 0.370798466662369 -0.175856264888536 0.628889502187424 mirMAP -0.329992689493064 2.30408320420021e-05 NA NA NA hsa-miR-129-2-3p CASP10 0.50442204005014 0.641848747681268 -0.175856264888536 0.628889502187424 mirMAP -0.126206731896347 2.25061853795193e-07 NA NA NA hsa-miR-129-5p CASP10 1.01348286569596 0.367116067584743 -0.175856264888536 0.628889502187424 mirMAP -0.132799791932563 5.3379187207394e-09 NA NA NA hsa-miR-144-5p CASP10 -2.20943490680765 0.00517103866061318 -0.175856264888536 0.628889502187424 mirMAP -0.0771043359692472 0.020974512633202 NA NA NA hsa-miR-148b-5p CASP10 -0.00680803632441723 0.990051364022285 -0.175856264888536 0.628889502187424 mirMAP -0.199839557793616 3.49016876982355e-05 NA NA NA hsa-miR-181c-5p CASP10 0.391426557741086 0.30540281172147 -0.175856264888536 0.628889502187424 mirMAP -0.194626766787821 0.00574461322602132 NA NA NA hsa-miR-30b-3p CASP10 -0.572694191047113 0.234897503722221 -0.175856264888536 0.628889502187424 MirTarget -0.157803049473018 0.00438323484202371 NA NA NA hsa-miR-338-3p CASP10 0.514743230435341 0.344476371008619 -0.175856264888536 0.628889502187424 miRanda -0.144433478774832 0.00315249693000991 NA NA NA hsa-miR-338-5p CASP10 0.336440913368409 0.532935762698486 -0.175856264888536 0.628889502187424 mirMAP -0.1238327368752 0.0124965320475888 NA NA NA hsa-miR-361-5p CASP10 -0.298789197467371 0.188640742693303 -0.175856264888536 0.628889502187424 miRanda -0.572498895730788 1.77113592748312e-06 NA NA NA hsa-miR-3613-3p CASP10 -0.973312457081501 0.056610643444148 -0.175856264888536 0.628889502187424 MirTarget -0.121174654860451 0.0243445092484162 NA NA NA hsa-miR-421 CASP10 -0.177803877528689 0.691941942432956 -0.175856264888536 0.628889502187424 mirMAP -0.318228280921853 5.29716176160815e-08 NA NA NA hsa-miR-592 CASP10 1.0317039684154 0.228885569586479 -0.175856264888536 0.628889502187424 miRNATAP -0.120993499859936 0.000769896195494753 NA NA NA hsa-miR-744-3p CASP10 -0.545474701469822 0.242282820962622 -0.175856264888536 0.628889502187424 mirMAP -0.344141838738403 3.69947241944793e-10 NA NA NA hsa-miR-129-5p CASP3 1.01348286569596 0.367116067584743 -0.00565221538616001 0.979410536244026 mirMAP -0.0597342059139703 1.68169528460903e-05 23744359 The intrinsic apoptotic pathway triggered by miR-129 was activated by cleavage of caspase-9 and caspase-3 colorectal cancer hsa-miR-137 CASP3 -0.0787835496950151 0.930521869365511 -0.00565221538616001 0.979410536244026 MirTarget;miRanda -0.0558453404226319 0.00241891050396197 27429846 Oncogenic miR 137 contributes to cisplatin resistance via repressing CASP3 in lung adenocarcinoma; Through computational prediction and microarray we identified caspase-3 CASP3 as a potential target of miR-137; Luciferase reporter and site-directed mutagenesis assays demonstrated that miR-137 downregulates CASP3 through binding to its 3'-UTR; Moreover the endogenous CASP3 can be modulated by overexpressing or silencing miR-137 in lung adenocarcinoma cell lines regardless of EGFR status; Suppression of CASP3 by miR-137 provides cancer cells with anti-apoptotic ability leading to cisplatin resistance; Immunohistochemistry results revealed an inverse correlation between miR-137 and CASP3 expressions in lung adenocarcinoma patients drug resistance lung cancer hsa-miR-139-5p CASP3 -1.63574949154462 0.00653778531863944 -0.00565221538616001 0.979410536244026 miRanda -0.0770738866836263 0.00324105696788515 NA NA NA hsa-miR-30a-5p CASP3 -0.588553206289925 0.175311638663077 -0.00565221538616001 0.979410536244026 miRNATAP -0.0801656116546111 0.0301668826363366 NA NA NA hsa-miR-30c-5p CASP3 -0.877497703999593 0.00776562825190586 -0.00565221538616001 0.979410536244026 miRNATAP -0.118871400078767 0.014788274733937 NA NA NA hsa-miR-98-5p CASP3 -0.2176359368719 0.422768546610498 -0.00565221538616001 0.979410536244026 MirTarget -0.212112316415034 0.000398816326180243 NA NA NA hsa-miR-125a-5p CASP6 -0.306104092733909 0.370798466662369 0.221403790485738 0.455313127542931 miRanda -0.342740648633633 3.92727994851623e-08 NA NA NA hsa-miR-129-5p CASP6 1.01348286569596 0.367116067584743 0.221403790485738 0.455313127542931 MirTarget;miRanda -0.109689920392397 2.96221396275778e-09 NA NA NA hsa-miR-369-3p CASP6 -0.832959746953411 0.173640923390195 0.221403790485738 0.455313127542931 MirTarget -0.150475934311536 1.54489278590268e-05 NA NA NA hsa-miR-129-5p CASP7 1.01348286569596 0.367116067584743 0.208654375090672 0.506643496479399 miRanda -0.0681629898037182 0.000758225058265541 NA NA NA hsa-miR-132-3p CASP7 -0.188684269862105 0.638562246194811 0.208654375090672 0.506643496479399 miRNAWalker2_validate;MirTarget -0.290014519354578 2.56362458047563e-07 NA NA NA hsa-miR-137 CASP7 -0.0787835496950151 0.930521869365511 0.208654375090672 0.506643496479399 miRanda -0.118079969385084 6.48877204175154e-06 NA NA NA hsa-miR-212-3p CASP7 -0.367966702435511 0.450158366088537 0.208654375090672 0.506643496479399 MirTarget -0.184385065403412 8.25491978952777e-05 NA NA NA hsa-miR-3065-3p CASP7 0.919910284231864 0.149524981714537 0.208654375090672 0.506643496479399 MirTarget -0.150403973227681 2.14716164803592e-05 NA NA NA hsa-miR-361-5p CASP7 -0.298789197467371 0.188640742693303 0.208654375090672 0.506643496479399 PITA;miRanda -0.370293406084843 0.000411354284702066 NA NA NA hsa-miR-543 CASP7 -1.03495265003894 0.0713462149984802 0.208654375090672 0.506643496479399 miRanda -0.160193442529892 5.68267569227645e-05 NA NA NA hsa-miR-664a-3p CASP7 -0.548519235569408 0.0680199398699682 0.208654375090672 0.506643496479399 MirTarget -0.188844456487502 0.0155054559426403 NA NA NA hsa-miR-107 CASP8 0.0358151350299583 0.899122490641298 -0.217026960952954 0.585797819892437 miRanda -0.219488968115046 0.0394340406584548 NA NA NA hsa-miR-129-5p CASP8 1.01348286569596 0.367116067584743 -0.217026960952954 0.585797819892437 miRanda -0.172331739333674 1.64771895121075e-12 NA NA NA hsa-miR-137 CASP8 -0.0787835496950151 0.930521869365511 -0.217026960952954 0.585797819892437 miRanda -0.081704334212907 0.0160019950623713 NA NA NA hsa-miR-296-3p CASP8 -0.404784919692806 0.503397985208349 -0.217026960952954 0.585797819892437 miRanda -0.154768311983131 0.00785326481263388 NA NA NA hsa-miR-3607-3p CASP8 -0.0996014475610343 0.818274259996261 -0.217026960952954 0.585797819892437 mirMAP -0.156150742110168 0.0217423828831078 NA NA NA hsa-miR-3613-3p CASP8 -0.973312457081501 0.056610643444148 -0.217026960952954 0.585797819892437 mirMAP -0.116049790804233 0.0493636276057564 NA NA NA hsa-miR-376a-3p CASP8 -0.604231855167556 0.342794419886032 -0.217026960952954 0.585797819892437 TargetScan -0.231135418619431 3.0259299086577e-07 NA NA NA hsa-miR-421 CASP8 -0.177803877528689 0.691941942432956 -0.217026960952954 0.585797819892437 miRanda -0.312046737309961 1.36692366760703e-06 NA NA NA hsa-miR-543 CASP8 -1.03495265003894 0.0713462149984802 -0.217026960952954 0.585797819892437 miRanda -0.227736767487875 5.80536752342635e-06 NA NA NA hsa-miR-125b-2-3p CASP9 0.588326920779072 0.241046956193588 -0.26224623558192 0.210016580340096 mirMAP -0.0774796335495149 0.0109192877280858 NA NA NA hsa-miR-103a-2-5p CFLAR -2.05541485118484 0.00116353312692819 -0.190881435119482 0.524428417196737 mirMAP -0.0819838197222901 0.0192275135910459 NA NA NA hsa-miR-125a-5p CFLAR -0.306104092733909 0.370798466662369 -0.190881435119482 0.524428417196737 miRanda -0.225724844059335 0.000479179477479602 NA NA NA hsa-miR-301a-3p CFLAR -0.756666069407079 0.0961303802724355 -0.190881435119482 0.524428417196737 mirMAP -0.202909642790542 2.15931362913065e-05 NA NA NA hsa-miR-30b-3p CFLAR -0.572694191047113 0.234897503722221 -0.190881435119482 0.524428417196737 mirMAP -0.119145319996255 0.00905319643646862 NA NA NA hsa-miR-338-3p CFLAR 0.514743230435341 0.344476371008619 -0.190881435119482 0.524428417196737 miRanda;mirMAP -0.136339522111569 0.000671862990582852 NA NA NA hsa-miR-3613-3p CFLAR -0.973312457081501 0.056610643444148 -0.190881435119482 0.524428417196737 mirMAP -0.0889282482658712 0.0448977202446967 NA NA NA hsa-miR-377-3p CFLAR -1.31382052580179 0.0227530245445242 -0.190881435119482 0.524428417196737 mirMAP -0.173842199388138 2.89813482881411e-06 NA NA NA hsa-miR-421 CFLAR -0.177803877528689 0.691941942432956 -0.190881435119482 0.524428417196737 miRanda -0.129492720357025 0.00908534586979413 NA NA NA hsa-miR-454-3p CFLAR -1.26819405185127 0.00175657340513321 -0.190881435119482 0.524428417196737 mirMAP -0.108505526806091 0.04499314579597 NA NA NA hsa-miR-455-5p CFLAR -0.230512086486246 0.540435117714922 -0.190881435119482 0.524428417196737 miRanda -0.191222118284556 0.00111055545059066 NA NA NA hsa-miR-543 CFLAR -1.03495265003894 0.0713462149984802 -0.190881435119482 0.524428417196737 miRanda -0.152135877148551 6.14040811161188e-05 NA NA NA hsa-miR-550a-5p CFLAR 0.440769041532644 0.370179182224153 -0.190881435119482 0.524428417196737 mirMAP -0.113482966708605 0.0117616444853437 NA NA NA hsa-miR-660-5p CFLAR -0.196889121709126 0.556115805668951 -0.190881435119482 0.524428417196737 mirMAP -0.157437482793424 0.0184495921728288 NA NA NA hsa-miR-7-5p CFLAR 0.818434078643802 0.510587133222615 -0.190881435119482 0.524428417196737 miRNAWalker2_validate -0.109481627367498 2.39013885348649e-08 NA NA NA hsa-miR-130a-5p CHUK -1.25302670373921 0.0116426772431465 0.142909702034959 0.46950208940272 MirTarget;miRNATAP -0.0798836810401758 0.00625565719335262 NA NA NA hsa-miR-339-5p CHUK -0.916407842972803 0.0433475651700471 0.142909702034959 0.46950208940272 miRanda -0.0821783482266822 0.00942774003811821 NA NA NA hsa-miR-424-5p CHUK -1.97114987995747 4.36503991925857e-07 0.142909702034959 0.46950208940272 MirTarget -0.102764004651333 0.00411587278515924 NA NA NA hsa-miR-181c-5p CSF2RB 0.391426557741086 0.30540281172147 -1.43547970729742 0.0385591456903776 MirTarget -0.373770714778382 0.00581425053792491 NA NA NA hsa-miR-181d-5p CSF2RB 0.69387721602585 0.0721613357370418 -1.43547970729742 0.0385591456903776 MirTarget -0.420830856413126 0.00158472323823835 NA NA NA hsa-miR-19a-3p CSF2RB -1.39804789764109 0.00390589133951138 -1.43547970729742 0.0385591456903776 MirTarget -0.22769020174392 0.0308923280428933 NA NA NA hsa-miR-19b-3p CSF2RB -1.3861807379685 0.00102515671649667 -1.43547970729742 0.0385591456903776 MirTarget -0.356842690159864 0.00303325808143672 NA NA NA hsa-miR-30b-3p CSF2RB -0.572694191047113 0.234897503722221 -1.43547970729742 0.0385591456903776 MirTarget -0.319668370795659 0.00265612569867923 NA NA NA hsa-miR-455-5p CSF2RB -0.230512086486246 0.540435117714922 -1.43547970729742 0.0385591456903776 miRanda -0.602876963483201 8.43484793650804e-06 NA NA NA hsa-miR-485-3p CSF2RB -1.07524599303664 0.0567048241974248 -1.43547970729742 0.0385591456903776 MirTarget -0.202873761871857 0.025555137343811 NA NA NA hsa-miR-342-3p CYCS -1.50859606438677 0.000361128404069141 0.518370651790815 0.0663254713693816 mirMAP -0.189858643635361 7.5565532908074e-05 NA NA NA hsa-miR-34c-5p CYCS -0.0182044536033139 0.971130549817106 0.518370651790815 0.0663254713693816 miRanda -0.11717124391218 0.0046702328624739 NA NA NA hsa-miR-148b-3p DFFA -0.0990745204340264 0.77230139028333 0.11012796389749 0.558116876698108 mirMAP -0.0912726448947378 0.0243627678822586 NA NA NA hsa-miR-26a-2-3p DFFA -0.911378552828573 0.0283482876675234 0.11012796389749 0.558116876698108 mirMAP -0.122761140113582 0.000160366305462712 NA NA NA hsa-miR-299-3p DFFA -1.19935146138053 0.0335319213117306 0.11012796389749 0.558116876698108 miRanda -0.059835112600171 0.0145662848319943 NA NA NA hsa-miR-335-5p DFFA -0.913728460165869 0.0568330413961764 0.11012796389749 0.558116876698108 mirMAP -0.0595906089290658 0.0365875373853658 NA NA NA hsa-miR-338-5p DFFA 0.336440913368409 0.532935762698486 0.11012796389749 0.558116876698108 mirMAP -0.0649539971217507 0.0103180101546125 NA NA NA hsa-miR-3607-3p DFFA -0.0996014475610343 0.818274259996261 0.11012796389749 0.558116876698108 mirMAP -0.0690947995390571 0.0296390300249981 NA NA NA hsa-miR-374a-5p DFFA -0.773847948304864 0.0214475199454759 0.11012796389749 0.558116876698108 mirMAP -0.115324008134548 0.00472900832571492 NA NA NA hsa-miR-376a-5p DFFA -1.11394176764617 0.0539029021682109 0.11012796389749 0.558116876698108 mirMAP -0.0596739473140357 0.0113900380829614 NA NA NA hsa-miR-497-3p DFFA -1.29342657868745 0.0163721815491619 0.11012796389749 0.558116876698108 mirMAP -0.0617877878874927 0.0168569713439476 NA NA NA hsa-miR-664a-3p DFFA -0.548519235569408 0.0680199398699682 0.11012796389749 0.558116876698108 mirMAP -0.115583637934143 0.0123584370121078 NA NA NA hsa-miR-130b-3p ENDOD1 -0.370221355490523 0.377261211782724 0.386516812534021 0.283262314101267 MirTarget -0.200634914457435 0.00150848203996803 NA NA NA hsa-miR-139-5p ENDOD1 -1.63574949154462 0.00653778531863944 0.386516812534021 0.283262314101267 miRanda -0.145601054915174 0.000768220311302963 NA NA NA hsa-miR-16-1-3p ENDOD1 -0.616362749214893 0.123693741249334 0.386516812534021 0.283262314101267 mirMAP -0.199745156469787 0.00257212652835737 NA NA NA hsa-miR-188-3p ENDOD1 -0.189720776141453 0.714532946225095 0.386516812534021 0.283262314101267 MirTarget -0.120320184788367 0.0237937665472239 NA NA NA hsa-miR-19a-3p ENDOD1 -1.39804789764109 0.00390589133951138 0.386516812534021 0.283262314101267 mirMAP -0.130032594364195 0.0166013279816963 NA NA NA hsa-miR-19b-3p ENDOD1 -1.3861807379685 0.00102515671649667 0.386516812534021 0.283262314101267 mirMAP -0.159200116737734 0.0105206287907118 NA NA NA hsa-miR-20a-3p ENDOD1 -1.06096832516061 0.0185360725543947 0.386516812534021 0.283262314101267 MirTarget -0.194741617904709 0.000828877701889656 NA NA NA hsa-miR-301a-3p ENDOD1 -0.756666069407079 0.0961303802724355 0.386516812534021 0.283262314101267 MirTarget -0.172099067474075 0.00314993595478718 NA NA NA hsa-miR-3613-3p ENDOD1 -0.973312457081501 0.056610643444148 0.386516812534021 0.283262314101267 mirMAP -0.122074574265166 0.0220654269607989 NA NA NA hsa-miR-3613-5p ENDOD1 -1.57318120093102 0.000766181957603027 0.386516812534021 0.283262314101267 MirTarget -0.211347204398077 0.000135821392574113 NA NA NA hsa-miR-362-3p ENDOD1 -1.20829972287608 0.012574092123476 0.386516812534021 0.283262314101267 miRanda -0.223683537910149 3.53646435801329e-05 NA NA NA hsa-miR-454-3p ENDOD1 -1.26819405185127 0.00175657340513321 0.386516812534021 0.283262314101267 MirTarget -0.173567418955656 0.00750758933782103 NA NA NA hsa-miR-543 ENDOD1 -1.03495265003894 0.0713462149984802 0.386516812534021 0.283262314101267 miRanda -0.13306019270499 0.00399473068844764 NA NA NA hsa-miR-589-3p ENDOD1 -1.10182934945547 0.0255972370236888 0.386516812534021 0.283262314101267 mirMAP -0.121626874129281 0.0235142798925796 NA NA NA hsa-miR-589-5p ENDOD1 -0.584949260545726 0.038531973588412 0.386516812534021 0.283262314101267 MirTarget -0.231209072976038 0.0155421941474337 NA NA NA hsa-miR-590-3p ENDOD1 -0.921957466414335 0.0345620969748757 0.386516812534021 0.283262314101267 miRanda -0.205584401570922 0.000647177074469549 NA NA NA hsa-miR-199a-5p EXOG -0.208670149801867 0.635984251700429 -0.417179900056931 0.0807375768632912 miRanda -0.108304892655716 0.00663364533147616 NA NA NA hsa-miR-200b-3p EXOG 1.84496256556404 0.00297111610556856 -0.417179900056931 0.0807375768632912 MirTarget -0.100942608020501 0.000252149915854154 NA NA NA hsa-miR-200c-3p EXOG 1.55610325614114 0.0126526013557324 -0.417179900056931 0.0807375768632912 MirTarget -0.101561630650899 0.000225347614116124 NA NA NA hsa-miR-24-3p EXOG -0.289152375604079 0.307732521516573 -0.417179900056931 0.0807375768632912 MirTarget -0.25111571468678 5.74144362022918e-05 NA NA NA hsa-miR-28-5p EXOG -0.527293772469832 0.0304183293001878 -0.417179900056931 0.0807375768632912 miRanda -0.195248418456104 0.00837213732249634 NA NA NA hsa-miR-429 EXOG 1.86385884044684 0.00726080911989418 -0.417179900056931 0.0807375768632912 MirTarget;miRanda -0.0673704076374379 0.00681687687715208 NA NA NA hsa-miR-129-5p FADD 1.01348286569596 0.367116067584743 0.246706566448252 0.278609180157715 miRanda -0.0764556593261427 8.4119227554716e-08 NA NA NA hsa-miR-3065-3p FADD 0.919910284231864 0.149524981714537 0.246706566448252 0.278609180157715 MirTarget -0.0571092423428277 0.0281687654194109 NA NA NA hsa-miR-342-3p FADD -1.50859606438677 0.000361128404069141 0.246706566448252 0.278609180157715 miRanda -0.077067773401312 0.0484753211621817 NA NA NA hsa-miR-361-5p FADD -0.298789197467371 0.188640742693303 0.246706566448252 0.278609180157715 MirTarget;miRanda;miRNATAP -0.280678192841509 0.000202053020353222 NA NA NA hsa-miR-7-5p FADD 0.818434078643802 0.510587133222615 0.246706566448252 0.278609180157715 miRNAWalker2_validate -0.0686694010854797 5.07862303726007e-06 NA NA NA hsa-miR-129-5p FAS 1.01348286569596 0.367116067584743 -0.127804865355837 0.728388618902938 miRanda -0.0891742776360477 0.000161743293735075 NA NA NA hsa-miR-23c FAS 0.27950019100417 0.578332232274096 -0.127804865355837 0.728388618902938 miRNATAP -0.150664789689346 0.0191817404026511 NA NA NA hsa-miR-338-3p FAS 0.514743230435341 0.344476371008619 -0.127804865355837 0.728388618902938 miRanda -0.123416233374483 0.0129254105605701 NA NA NA hsa-miR-361-5p FAS -0.298789197467371 0.188640742693303 -0.127804865355837 0.728388618902938 miRanda -0.312263957654549 0.011755088196395 NA NA NA hsa-miR-3613-3p FAS -0.973312457081501 0.056610643444148 -0.127804865355837 0.728388618902938 mirMAP -0.143987887740709 0.00798498086575489 NA NA NA hsa-miR-491-5p FAS -0.787801664777276 0.12392872487051 -0.127804865355837 0.728388618902938 miRanda -0.18679871146283 0.000380897254513407 NA NA NA hsa-miR-496 FAS -0.263423110562247 0.668883492994483 -0.127804865355837 0.728388618902938 miRanda -0.108858005023058 0.013047674805249 NA NA NA hsa-miR-590-5p FAS -0.984421368732497 0.00533663360221062 -0.127804865355837 0.728388618902938 miRanda -0.246110415056917 0.0012469451167991 NA NA NA hsa-miR-98-5p FAS -0.2176359368719 0.422768546610498 -0.127804865355837 0.728388618902938 miRNAWalker2_validate -0.461708672002764 4.09472527085397e-06 NA NA NA hsa-miR-92a-3p FASLG -0.417284456385998 0.14690346065742 -1.74306761439974 0.01264326002843 miRNATAP -0.372012680208554 0.044205313124071 NA NA NA hsa-miR-92b-3p FASLG 0.514365666378666 0.186565269716391 -1.74306761439974 0.01264326002843 miRNATAP -0.44361905158915 0.000881794772973363 NA NA NA hsa-miR-129-5p IKBKB 1.01348286569596 0.367116067584743 -0.315568949182873 0.221054275286368 miRanda -0.0537840634433028 0.00120480521680103 NA NA NA hsa-miR-324-5p IKBKB -0.993343053719004 0.00956564321262937 -0.315568949182873 0.221054275286368 miRanda -0.111251733321391 0.0243552785576533 NA NA NA hsa-miR-330-5p IKBKB 0.647187634039027 0.0863451847130066 -0.315568949182873 0.221054275286368 miRanda -0.100890809881282 0.0460146195142921 NA NA NA hsa-miR-369-3p IKBKB -0.832959746953411 0.173640923390195 -0.315568949182873 0.221054275286368 miRNATAP -0.122795299209338 5.20559323068256e-05 NA NA NA hsa-miR-491-5p IKBKB -0.787801664777276 0.12392872487051 -0.315568949182873 0.221054275286368 miRanda -0.101544259443499 0.00608115829575896 NA NA NA hsa-miR-543 IKBKB -1.03495265003894 0.0713462149984802 -0.315568949182873 0.221054275286368 miRanda -0.104402916094188 0.001504535456054 NA NA NA hsa-miR-107 IKBKG 0.0358151350299583 0.899122490641298 -0.134045186419238 0.557130087475058 miRanda -0.156930075673466 0.00944333263511804 NA NA NA hsa-miR-323b-3p IKBKG -0.893427137441785 0.288815437550969 -0.134045186419238 0.557130087475058 mirMAP -0.0713993918099061 0.000248852273285984 NA NA NA hsa-miR-330-3p IKBKG 0.226896608253308 0.63792060187889 -0.134045186419238 0.557130087475058 mirMAP -0.104325159644854 0.00252874206924041 NA NA NA hsa-miR-377-5p IKBKG -0.949720690015513 0.157360304303177 -0.134045186419238 0.557130087475058 mirMAP -0.0705640824653479 0.0135616288618738 NA NA NA hsa-miR-432-5p IKBKG -0.187109431374392 0.743519757702476 -0.134045186419238 0.557130087475058 mirMAP -0.081520844160303 0.00507013077178485 NA NA NA hsa-miR-485-3p IKBKG -1.07524599303664 0.0567048241974248 -0.134045186419238 0.557130087475058 mirMAP -0.0658076903786919 0.0254979832047243 NA NA NA hsa-miR-30d-5p IL1A -0.00941045381462047 0.974732483265334 -0.622799419614805 0.56215139938033 MirTarget -0.800114068440149 0.00322703393998323 NA NA NA hsa-miR-532-5p IL1A -0.151278849273279 0.643095677227945 -0.622799419614805 0.56215139938033 MirTarget -0.838455414182654 0.000616271096126315 NA NA NA hsa-miR-590-3p IL1A -0.921957466414335 0.0345620969748757 -0.622799419614805 0.56215139938033 miRanda;mirMAP -0.371927223809522 0.0411045747196078 NA NA NA hsa-miR-17-3p IL1R1 -0.0709436934154812 0.786428153888425 -0.111297263903406 0.839720710654847 mirMAP -0.35715178211711 0.0254127012761371 NA NA NA hsa-miR-186-5p IL1R1 -0.76553299921128 0.00203425234898652 -0.111297263903406 0.839720710654847 mirMAP -0.586274585073176 0.000391039185306635 NA NA NA hsa-miR-192-5p IL1R1 2.0972919255143 0.00232678828970491 -0.111297263903406 0.839720710654847 miRNAWalker2_validate -0.311265430533607 2.79278198406659e-08 NA NA NA hsa-miR-24-3p IL1R1 -0.289152375604079 0.307732521516573 -0.111297263903406 0.839720710654847 miRNATAP -0.333931752172484 0.0226352582758226 NA NA NA hsa-miR-26a-5p IL1R1 -0.595418372285298 0.0245871761064168 -0.111297263903406 0.839720710654847 mirMAP -0.355965657382719 0.0230543460805732 NA NA NA hsa-miR-26b-5p IL1R1 -1.21629873619115 0.000852008439136243 -0.111297263903406 0.839720710654847 mirMAP -0.396968813377911 0.000293773703662919 NA NA NA hsa-miR-30d-3p IL1R1 -0.362535627574237 0.323541946435653 -0.111297263903406 0.839720710654847 mirMAP -0.339802035863877 0.00219540829417969 NA NA NA hsa-miR-335-3p IL1R1 -0.496550554602651 0.223248314670008 -0.111297263903406 0.839720710654847 mirMAP -0.436917233379859 8.43545805940529e-06 NA NA NA hsa-miR-361-5p IL1R1 -0.298789197467371 0.188640742693303 -0.111297263903406 0.839720710654847 miRanda -0.727532606041575 7.23903146083187e-05 NA NA NA hsa-miR-3613-3p IL1R1 -0.973312457081501 0.056610643444148 -0.111297263903406 0.839720710654847 mirMAP -0.252287357296513 0.0018501798737818 NA NA NA hsa-miR-377-3p IL1R1 -1.31382052580179 0.0227530245445242 -0.111297263903406 0.839720710654847 mirMAP -0.208542463356508 0.00275974635630778 NA NA NA hsa-miR-491-5p IL1R1 -0.787801664777276 0.12392872487051 -0.111297263903406 0.839720710654847 miRanda -0.161263235398736 0.0430545148858622 NA NA NA hsa-miR-495-3p IL1R1 -0.819711095165138 0.0930619218141869 -0.111297263903406 0.839720710654847 mirMAP -0.176171485198565 0.0340938561367844 NA NA NA hsa-miR-590-3p IL1R1 -0.921957466414335 0.0345620969748757 -0.111297263903406 0.839720710654847 miRanda;miRNATAP -0.440049853811961 1.2132854427223e-06 NA NA NA hsa-miR-1224-5p IL1RAP 1.83900215224088 0.106580080531242 0.239637995601285 0.677201946802569 MirTarget -0.16323868686658 1.10505387808564e-05 NA NA NA hsa-miR-129-5p IL1RAP 1.01348286569596 0.367116067584743 0.239637995601285 0.677201946802569 miRanda -0.143541123028653 0.000105828097730755 NA NA NA hsa-miR-139-5p IL1RAP -1.63574949154462 0.00653778531863944 0.239637995601285 0.677201946802569 miRanda -0.398407739666551 2.79183333330375e-09 NA NA NA hsa-miR-140-5p IL1RAP -1.19629127894344 4.39286577178892e-05 0.239637995601285 0.677201946802569 miRanda -0.411014889002018 0.00438940207089995 NA NA NA hsa-miR-16-1-3p IL1RAP -0.616362749214893 0.123693741249334 0.239637995601285 0.677201946802569 mirMAP -0.238671120292563 0.0251694527001708 NA NA NA hsa-miR-186-5p IL1RAP -0.76553299921128 0.00203425234898652 0.239637995601285 0.677201946802569 mirMAP -0.570944307311761 0.000994011973068504 NA NA NA hsa-miR-192-5p IL1RAP 2.0972919255143 0.00232678828970491 0.239637995601285 0.677201946802569 miRNAWalker2_validate -0.158107555535026 0.00907776430394785 NA NA NA hsa-miR-19b-3p IL1RAP -1.3861807379685 0.00102515671649667 0.239637995601285 0.677201946802569 MirTarget -0.21525868924725 0.0310629985720916 NA NA NA hsa-miR-204-5p IL1RAP -1.12734477908708 0.190740222987981 0.239637995601285 0.677201946802569 miRNAWalker2_validate -0.16834927589555 0.000517589007254546 NA NA NA hsa-miR-299-3p IL1RAP -1.19935146138053 0.0335319213117306 0.239637995601285 0.677201946802569 miRanda -0.177455314489773 0.0196404968574718 NA NA NA hsa-miR-29b-3p IL1RAP -0.392267406583841 0.343581862655996 0.239637995601285 0.677201946802569 MirTarget;miRNATAP -0.528088961574279 1.28062816913365e-07 NA NA NA hsa-miR-29c-3p IL1RAP -0.133603914094895 0.743610228811317 0.239637995601285 0.677201946802569 MirTarget;miRNATAP -0.556545702384581 3.82659530158622e-08 NA NA NA hsa-miR-301a-3p IL1RAP -0.756666069407079 0.0961303802724355 0.239637995601285 0.677201946802569 MirTarget -0.468770927191533 2.60211264975691e-07 NA NA NA hsa-miR-3065-5p IL1RAP 0.744542127327022 0.29683696958743 0.239637995601285 0.677201946802569 mirMAP -0.217544852332165 0.000202666983531018 NA NA NA hsa-miR-339-5p IL1RAP -0.916407842972803 0.0433475651700471 0.239637995601285 0.677201946802569 miRanda -0.233076530673842 0.0125694067950157 NA NA NA hsa-miR-3607-3p IL1RAP -0.0996014475610343 0.818274259996261 0.239637995601285 0.677201946802569 mirMAP -0.373240623231034 0.000123855279304182 NA NA NA hsa-miR-361-5p IL1RAP -0.298789197467371 0.188640742693303 0.239637995601285 0.677201946802569 miRanda -0.528937543555514 0.00641549086486633 NA NA NA hsa-miR-3613-3p IL1RAP -0.973312457081501 0.056610643444148 0.239637995601285 0.677201946802569 mirMAP -0.236957587896939 0.00532084527971468 NA NA NA hsa-miR-362-3p IL1RAP -1.20829972287608 0.012574092123476 0.239637995601285 0.677201946802569 miRanda -0.274812077086846 0.00166348687088545 NA NA NA hsa-miR-375 IL1RAP 2.45956739868952 0.0171124871214617 0.239637995601285 0.677201946802569 miRNAWalker2_validate;miRanda -0.204291226004255 2.23176840125082e-07 NA NA NA hsa-miR-421 IL1RAP -0.177803877528689 0.691941942432956 0.239637995601285 0.677201946802569 MirTarget;miRanda -0.286956432969203 0.00262445483905067 NA NA NA hsa-miR-454-3p IL1RAP -1.26819405185127 0.00175657340513321 0.239637995601285 0.677201946802569 MirTarget -0.44456103177153 1.36623372614549e-05 NA NA NA hsa-miR-455-5p IL1RAP -0.230512086486246 0.540435117714922 0.239637995601285 0.677201946802569 miRanda -0.258603864425296 0.023161185469988 NA NA NA hsa-miR-496 IL1RAP -0.263423110562247 0.668883492994483 0.239637995601285 0.677201946802569 miRanda -0.139779340128998 0.0426433350530856 NA NA NA hsa-miR-543 IL1RAP -1.03495265003894 0.0713462149984802 0.239637995601285 0.677201946802569 miRanda;miRNATAP -0.241329301760513 0.00106060014492953 NA NA NA hsa-miR-577 IL1RAP 0.810246698380877 0.314263384393584 0.239637995601285 0.677201946802569 mirMAP -0.183723993709825 0.000419932052584001 NA NA NA hsa-miR-582-5p IL1RAP -0.241398739931134 0.638696591630038 0.239637995601285 0.677201946802569 MirTarget -0.391317292486887 1.2299874710285e-06 NA NA NA hsa-miR-590-3p IL1RAP -0.921957466414335 0.0345620969748757 0.239637995601285 0.677201946802569 MirTarget;miRanda;mirMAP -0.377144647992547 8.44316207722099e-05 NA NA NA hsa-miR-590-5p IL1RAP -0.984421368732497 0.00533663360221062 0.239637995601285 0.677201946802569 miRanda -0.460391043136263 0.000106467108136581 NA NA NA hsa-miR-628-3p IL1RAP -1.91638836103701 0.00403880122996397 0.239637995601285 0.677201946802569 mirMAP -0.222564583525099 0.00037474861500238 NA NA NA hsa-miR-664a-3p IL1RAP -0.548519235569408 0.0680199398699682 0.239637995601285 0.677201946802569 mirMAP -0.550173314472697 0.00010264305770374 NA NA NA hsa-miR-7-1-3p IL1RAP -0.729687864305395 0.0834004484481893 0.239637995601285 0.677201946802569 MirTarget -0.497384431893379 4.10282877361542e-07 NA NA NA hsa-miR-95-3p IL1RAP -0.968467930117736 0.124908226995684 0.239637995601285 0.677201946802569 MirTarget -0.443697132617457 2.01474519084383e-12 NA NA NA hsa-miR-132-3p IRAK1 -0.188684269862105 0.638562246194811 0.232582604880435 0.385647740170123 miRNAWalker2_validate -0.158451964507983 0.00122374987467018 NA NA NA hsa-miR-328-3p IRAK1 -0.616513764487744 0.130645662338363 0.232582604880435 0.385647740170123 miRNAWalker2_validate -0.135872624277821 0.00488218587005962 NA NA NA hsa-miR-330-5p IRAK1 0.647187634039027 0.0863451847130066 0.232582604880435 0.385647740170123 miRNAWalker2_validate -0.130722310876514 0.0125803648319682 NA NA NA hsa-miR-744-5p IRAK1 -0.595778447321061 0.172283646202662 0.232582604880435 0.385647740170123 miRNAWalker2_validate -0.139649118693515 0.00188534638892659 NA NA NA hsa-miR-3065-5p IRAK2 0.744542127327022 0.29683696958743 0.151006019401687 0.774281890080186 mirMAP -0.11186038536084 0.0391690549728444 NA NA NA hsa-miR-141-3p IRAK3 1.13131842772144 0.0966666388085424 -0.545054856557432 0.290629172118902 mirMAP -0.209961174146202 0.000129733413692371 NA NA NA hsa-miR-148b-5p IRAK3 -0.00680803632441723 0.990051364022285 -0.545054856557432 0.290629172118902 mirMAP -0.269627214383906 8.96187373189339e-05 NA NA NA hsa-miR-16-1-3p IRAK3 -0.616362749214893 0.123693741249334 -0.545054856557432 0.290629172118902 mirMAP -0.25339916545766 0.00786092040654695 NA NA NA hsa-miR-16-5p IRAK3 -1.02296420363147 0.000327333184982762 -0.545054856557432 0.290629172118902 miRNAWalker2_validate -0.414862940201552 0.00191855284573896 NA NA NA hsa-miR-200a-3p IRAK3 1.68929243108599 0.00872253595562164 -0.545054856557432 0.290629172118902 mirMAP -0.174614058917905 0.00268368200579395 NA NA NA hsa-miR-29b-2-5p IRAK3 -0.615199776501198 0.100092846442163 -0.545054856557432 0.290629172118902 mirMAP -0.24920498789826 0.0149280889870475 NA NA NA hsa-miR-32-5p IRAK3 -1.1697502932723 0.00457026320106483 -0.545054856557432 0.290629172118902 mirMAP -0.352266738086829 0.000103291719093032 NA NA NA hsa-miR-3200-3p IRAK3 -0.505033418058224 0.480173693608916 -0.545054856557432 0.290629172118902 mirMAP -0.235428571618344 7.51694488066356e-06 NA NA NA hsa-miR-324-5p IRAK3 -0.993343053719004 0.00956564321262937 -0.545054856557432 0.290629172118902 miRanda -0.382306062900955 9.59481843080934e-05 NA NA NA hsa-miR-335-3p IRAK3 -0.496550554602651 0.223248314670008 -0.545054856557432 0.290629172118902 mirMAP -0.219491626769225 0.019401763956603 NA NA NA hsa-miR-338-5p IRAK3 0.336440913368409 0.532935762698486 -0.545054856557432 0.290629172118902 mirMAP -0.196676805259332 0.00517999751245285 NA NA NA hsa-miR-33a-5p IRAK3 -0.993826765770883 0.0645799435927515 -0.545054856557432 0.290629172118902 mirMAP -0.242076514353804 0.000554124677336194 NA NA NA hsa-miR-33b-5p IRAK3 0.621849465135339 0.329304820187453 -0.545054856557432 0.290629172118902 mirMAP -0.317024261374558 9.3575193623868e-08 NA NA NA hsa-miR-340-5p IRAK3 -0.873554108779771 0.0362049958643107 -0.545054856557432 0.290629172118902 mirMAP -0.250262834413271 0.00600865228811545 NA NA NA hsa-miR-361-5p IRAK3 -0.298789197467371 0.188640742693303 -0.545054856557432 0.290629172118902 miRanda;mirMAP -0.488252024791477 0.00499461791935898 NA NA NA hsa-miR-369-3p IRAK3 -0.832959746953411 0.173640923390195 -0.545054856557432 0.290629172118902 mirMAP -0.226390445654385 0.000219820619044851 NA NA NA hsa-miR-376a-5p IRAK3 -1.11394176764617 0.0539029021682109 -0.545054856557432 0.290629172118902 mirMAP -0.193649648992158 0.00307201617774836 NA NA NA hsa-miR-376c-3p IRAK3 -0.880097002159101 0.0727217919154321 -0.545054856557432 0.290629172118902 mirMAP -0.235415957318711 0.00232510784063171 NA NA NA hsa-miR-421 IRAK3 -0.177803877528689 0.691941942432956 -0.545054856557432 0.290629172118902 miRanda;mirMAP -0.223925366943701 0.00905745286054573 NA NA NA hsa-miR-429 IRAK3 1.86385884044684 0.00726080911989418 -0.545054856557432 0.290629172118902 miRanda -0.202107769575725 0.000158694618771533 NA NA NA hsa-miR-496 IRAK3 -0.263423110562247 0.668883492994483 -0.545054856557432 0.290629172118902 miRanda -0.133696983237287 0.0304783119815842 NA NA NA hsa-miR-501-5p IRAK3 -0.634663345778922 0.169048284923239 -0.545054856557432 0.290629172118902 mirMAP -0.194017719916743 0.0191919654020302 NA NA NA hsa-miR-543 IRAK3 -1.03495265003894 0.0713462149984802 -0.545054856557432 0.290629172118902 miRanda -0.185612736909357 0.00516285695763025 NA NA NA hsa-miR-577 IRAK3 0.810246698380877 0.314263384393584 -0.545054856557432 0.290629172118902 mirMAP -0.1508585893011 0.00128010025804023 NA NA NA hsa-miR-582-5p IRAK3 -0.241398739931134 0.638696591630038 -0.545054856557432 0.290629172118902 mirMAP -0.191069561065111 0.00985512664853094 NA NA NA hsa-miR-589-3p IRAK3 -1.10182934945547 0.0255972370236888 -0.545054856557432 0.290629172118902 mirMAP -0.207488920691087 0.00691519707545513 NA NA NA hsa-miR-590-3p IRAK3 -0.921957466414335 0.0345620969748757 -0.545054856557432 0.290629172118902 miRanda;mirMAP -0.302450567639033 0.000464783559842425 NA NA NA hsa-miR-590-5p IRAK3 -0.984421368732497 0.00533663360221062 -0.545054856557432 0.290629172118902 mirMAP -0.351940746142123 0.00102233503282289 NA NA NA hsa-miR-628-3p IRAK3 -1.91638836103701 0.00403880122996397 -0.545054856557432 0.290629172118902 mirMAP -0.128819230325744 0.0230656288861917 NA NA NA hsa-miR-7-1-3p IRAK3 -0.729687864305395 0.0834004484481893 -0.545054856557432 0.290629172118902 mirMAP -0.226354866536401 0.0123236206748619 NA NA NA hsa-miR-92b-3p IRAK3 0.514365666378666 0.186565269716391 -0.545054856557432 0.290629172118902 mirMAP -0.335351309563093 0.000586686661331712 NA NA NA hsa-miR-429 IRAK4 1.86385884044684 0.00726080911989418 -0.411235730316537 0.0381154788134052 miRanda -0.074915431478825 0.000248465971092419 NA NA NA hsa-miR-493-5p IRAK4 -0.379454795693971 0.325491044603386 -0.411235730316537 0.0381154788134052 mirMAP -0.146683756626074 8.94851067036071e-05 NA NA NA hsa-miR-429 MAP3K14 1.86385884044684 0.00726080911989418 -0.770717550250517 0.0108717109421317 miRNATAP -0.131166266553698 2.89589550416201e-05 NA NA NA hsa-miR-874-3p MAP3K14 -0.134091707830919 0.772470526227307 -0.770717550250517 0.0108717109421317 MirTarget -0.0988885769498734 0.0419293651470894 NA NA NA hsa-miR-29b-2-5p MYD88 -0.615199776501198 0.100092846442163 -0.213825899106104 0.450971021107713 MirTarget -0.16491829653469 0.00311205634613586 NA NA NA hsa-miR-491-5p MYD88 -0.787801664777276 0.12392872487051 -0.213825899106104 0.450971021107713 miRanda -0.128184367025304 0.00158614920747213 NA NA NA hsa-miR-338-3p NFKB1 0.514743230435341 0.344476371008619 -0.425832424862656 0.0592721356006074 miRanda -0.149956399818248 4.0656557783722e-07 NA NA NA hsa-miR-338-5p NFKB1 0.336440913368409 0.532935762698486 -0.425832424862656 0.0592721356006074 miRNATAP -0.0944601854141777 0.00199538420387146 NA NA NA hsa-miR-340-5p NFKB1 -0.873554108779771 0.0362049958643107 -0.425832424862656 0.0592721356006074 miRNATAP -0.100682722657369 0.0112650824158742 NA NA NA hsa-miR-429 NGF 1.86385884044684 0.00726080911989418 -0.757715039127912 0.232043603182556 miRanda -0.297717769244721 5.07075835077408e-06 NA NA NA hsa-miR-148b-3p PIK3CA -0.0990745204340264 0.77230139028333 -0.202433391186421 0.541225913162929 miRNAWalker2_validate -0.325589982618743 4.00375800127887e-06 NA NA NA hsa-miR-16-2-3p PIK3CA -1.02821208937232 0.00734958396812714 -0.202433391186421 0.541225913162929 mirMAP -0.214026885915626 0.000674205063111468 NA NA NA hsa-miR-186-5p PIK3CA -0.76553299921128 0.00203425234898652 -0.202433391186421 0.541225913162929 mirMAP -0.234052190418959 0.0195685534015644 NA NA NA hsa-miR-200b-3p PIK3CA 1.84496256556404 0.00297111610556856 -0.202433391186421 0.541225913162929 TargetScan -0.125468683073313 0.00109554121546099 NA NA NA hsa-miR-335-3p PIK3CA -0.496550554602651 0.223248314670008 -0.202433391186421 0.541225913162929 mirMAP -0.159951993001222 0.0076203367857745 NA NA NA hsa-miR-335-5p PIK3CA -0.913728460165869 0.0568330413961764 -0.202433391186421 0.541225913162929 miRNAWalker2_validate -0.229764804818245 3.59714703507461e-06 NA NA NA hsa-miR-339-5p PIK3CA -0.916407842972803 0.0433475651700471 -0.202433391186421 0.541225913162929 miRanda -0.25023137603408 1.78487035222252e-06 NA NA NA hsa-miR-3607-3p PIK3CA -0.0996014475610343 0.818274259996261 -0.202433391186421 0.541225913162929 mirMAP -0.166965291775544 0.00299728800217905 NA NA NA hsa-miR-3613-3p PIK3CA -0.973312457081501 0.056610643444148 -0.202433391186421 0.541225913162929 mirMAP -0.10939258742677 0.0255142081165888 NA NA NA hsa-miR-374a-5p PIK3CA -0.773847948304864 0.0214475199454759 -0.202433391186421 0.541225913162929 mirMAP -0.149808702817021 0.0403541903827596 NA NA NA hsa-miR-374b-5p PIK3CA -0.936361879691007 0.00140373477346958 -0.202433391186421 0.541225913162929 mirMAP -0.313089239956441 0.000154146510529707 NA NA NA hsa-miR-376a-3p PIK3CA -0.604231855167556 0.342794419886032 -0.202433391186421 0.541225913162929 mirMAP -0.140724712909478 0.000224540561757994 NA NA NA hsa-miR-376b-3p PIK3CA -0.430057307730791 0.464944123527867 -0.202433391186421 0.541225913162929 mirMAP -0.149179768528924 0.000299278047417527 NA NA NA hsa-miR-501-5p PIK3CA -0.634663345778922 0.169048284923239 -0.202433391186421 0.541225913162929 mirMAP -0.178571326639903 0.000682497122143923 NA NA NA hsa-miR-577 PIK3CA 0.810246698380877 0.314263384393584 -0.202433391186421 0.541225913162929 mirMAP -0.107269558068807 0.00032933016197645 NA NA NA hsa-miR-590-3p PIK3CA -0.921957466414335 0.0345620969748757 -0.202433391186421 0.541225913162929 miRanda;mirMAP -0.207815819332441 0.000164113944876951 NA NA NA hsa-miR-590-5p PIK3CA -0.984421368732497 0.00533663360221062 -0.202433391186421 0.541225913162929 miRanda -0.242111483625755 0.000401043654263406 NA NA NA hsa-miR-7-1-3p PIK3CA -0.729687864305395 0.0834004484481893 -0.202433391186421 0.541225913162929 mirMAP -0.147455777785472 0.0108104605089679 NA NA NA hsa-miR-96-5p PIK3CA -0.14300109523641 0.834020197937914 -0.202433391186421 0.541225913162929 TargetScan -0.210303012933278 6.66846558054534e-10 NA NA NA hsa-miR-126-5p PIK3CB -1.40161784967373 0.000199780495822923 0.274107369326599 0.235819352447471 mirMAP -0.177495718509574 5.22213931263905e-05 NA NA NA hsa-miR-204-5p PIK3CB -1.12734477908708 0.190740222987981 0.274107369326599 0.235819352447471 miRNATAP -0.0657598167953127 0.000681849024671467 NA NA NA hsa-miR-301a-3p PIK3CB -0.756666069407079 0.0961303802724355 0.274107369326599 0.235819352447471 miRNATAP -0.134080059178609 0.000287795960504585 NA NA NA hsa-miR-32-5p PIK3CB -1.1697502932723 0.00457026320106483 0.274107369326599 0.235819352447471 miRNATAP -0.102017138369303 0.012513636309414 NA NA NA hsa-miR-362-5p PIK3CB -0.73199764539445 0.112060703377193 0.274107369326599 0.235819352447471 TargetScan -0.0880315317198547 0.0166702210274428 NA NA NA hsa-miR-376a-3p PIK3CB -0.604231855167556 0.342794419886032 0.274107369326599 0.235819352447471 TargetScan -0.0861498919580105 0.00121565357716601 NA NA NA hsa-miR-454-3p PIK3CB -1.26819405185127 0.00175657340513321 0.274107369326599 0.235819352447471 miRNATAP -0.138124860729189 0.000802341502927855 NA NA NA hsa-miR-7-5p PIK3CB 0.818434078643802 0.510587133222615 0.274107369326599 0.235819352447471 miRNAWalker2_validate -0.0851358472350516 1.60309632844627e-08 NA NA NA hsa-miR-135a-5p PIK3CD -0.197337318548759 0.83089129366921 -1.55636987076599 0.00166599011504136 miRNATAP -0.0944957379216108 0.0185743751748679 NA NA NA hsa-miR-30b-3p PIK3CD -0.572694191047113 0.234897503722221 -1.55636987076599 0.00166599011504136 MirTarget -0.168983650057529 0.0278640577963164 NA NA NA hsa-miR-30d-5p PIK3CD -0.00941045381462047 0.974732483265334 -1.55636987076599 0.00166599011504136 MirTarget;miRNATAP -0.542245835865164 1.40086145194174e-05 NA NA NA hsa-miR-148b-3p PIK3CG -0.0990745204340264 0.77230139028333 -1.54505987847342 0.036958145554377 miRNAWalker2_validate -0.665281394981098 3.27864117921355e-05 NA NA NA hsa-miR-29b-3p PIK3CG -0.392267406583841 0.343581862655996 -1.54505987847342 0.036958145554377 miRTarBase -0.442202401256576 0.00084120200105816 NA NA NA hsa-miR-3613-3p PIK3CG -0.973312457081501 0.056610643444148 -1.54505987847342 0.036958145554377 mirMAP -0.24389865488811 0.0273328882984898 NA NA NA hsa-miR-106b-5p PIK3R1 -0.814181559290382 0.00942928404699138 -0.50810055834123 0.168154223202089 MirTarget;miRNATAP -0.241102264390517 0.00569770859977529 NA NA NA hsa-miR-16-2-3p PIK3R1 -1.02821208937232 0.00734958396812714 -0.50810055834123 0.168154223202089 MirTarget -0.278479899538267 6.68888102350106e-05 NA NA NA hsa-miR-17-5p PIK3R1 -0.667512721923102 0.0423050196597589 -0.50810055834123 0.168154223202089 MirTarget;TargetScan;miRNATAP -0.200517806384386 0.0163577919151925 NA NA NA hsa-miR-182-5p PIK3R1 0.193824666419893 0.730295924168823 -0.50810055834123 0.168154223202089 miRNATAP -0.225762627795778 1.74463443367172e-06 NA NA NA hsa-miR-200b-3p PIK3R1 1.84496256556404 0.00297111610556856 -0.50810055834123 0.168154223202089 mirMAP -0.201008431427858 1.89973545873789e-06 NA NA NA hsa-miR-200c-3p PIK3R1 1.55610325614114 0.0126526013557324 -0.50810055834123 0.168154223202089 mirMAP -0.155387662664723 0.000271926317292563 NA NA NA hsa-miR-20a-5p PIK3R1 -0.39483820331792 0.269587643143535 -0.50810055834123 0.168154223202089 MirTarget;miRNATAP -0.2115774692061 0.00574268182198667 NA NA NA hsa-miR-22-5p PIK3R1 -1.59873893702871 1.3870338571363e-05 -0.50810055834123 0.168154223202089 mirMAP -0.207842262802008 0.00416141067877236 NA NA NA hsa-miR-222-3p PIK3R1 -0.0877773876099193 0.858023207350706 -0.50810055834123 0.168154223202089 MirTarget -0.134604270947204 0.0153469052538768 NA NA NA hsa-miR-29b-3p PIK3R1 -0.392267406583841 0.343581862655996 -0.50810055834123 0.168154223202089 MirTarget;miRNATAP -0.302458011013782 2.79667770077503e-06 NA NA NA hsa-miR-3065-5p PIK3R1 0.744542127327022 0.29683696958743 -0.50810055834123 0.168154223202089 MirTarget;mirMAP;miRNATAP -0.0983058904079289 0.00942301968627346 NA NA NA hsa-miR-429 PIK3R1 1.86385884044684 0.00726080911989418 -0.50810055834123 0.168154223202089 mirMAP;miRNATAP -0.217235414882175 5.24072929501288e-09 NA NA NA hsa-miR-590-3p PIK3R1 -0.921957466414335 0.0345620969748757 -0.50810055834123 0.168154223202089 miRanda;mirMAP -0.165514087644316 0.00774055301342508 NA NA NA hsa-miR-590-5p PIK3R1 -0.984421368732497 0.00533663360221062 -0.50810055834123 0.168154223202089 MirTarget;PITA;miRanda;miRNATAP -0.188176512940724 0.0145808630621089 NA NA NA hsa-miR-96-5p PIK3R1 -0.14300109523641 0.834020197937914 -0.50810055834123 0.168154223202089 TargetScan;miRNATAP -0.244991841895714 9.3592061964339e-11 NA NA NA hsa-miR-28-5p PIK3R2 -0.527293772469832 0.0304183293001878 0.20787386392914 0.323508176663381 miRanda -0.312178824660191 8.43782422220933e-07 NA NA NA hsa-miR-30a-5p PIK3R2 -0.588553206289925 0.175311638663077 0.20787386392914 0.323508176663381 miRNATAP -0.145885262700304 2.99227122991063e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.989157025063461 0.00041808608143741 0.20787386392914 0.323508176663381 miRNATAP -0.121493514899163 0.0280831143830336 NA NA NA hsa-miR-181a-5p PIK3R3 -0.102992950182657 0.777433141199684 0.164484201062998 0.650310662056234 MirTarget;miRNATAP -0.324638029696344 7.84694322504695e-06 NA NA NA hsa-miR-181b-5p PIK3R3 0.253272120717567 0.563522710157574 0.164484201062998 0.650310662056234 MirTarget;miRNATAP -0.288082534921529 1.39891518071466e-06 NA NA NA hsa-miR-182-5p PIK3R3 0.193824666419893 0.730295924168823 0.164484201062998 0.650310662056234 mirMAP -0.192707505272877 3.72363221899495e-05 NA NA NA hsa-miR-19a-3p PIK3R3 -1.39804789764109 0.00390589133951138 0.164484201062998 0.650310662056234 MirTarget;miRNATAP -0.175464423606178 0.00122100303187813 NA NA NA hsa-miR-19b-3p PIK3R3 -1.3861807379685 0.00102515671649667 0.164484201062998 0.650310662056234 MirTarget;miRNATAP -0.243527074480167 8.21658401745744e-05 NA NA NA hsa-miR-26b-5p PIK3R3 -1.21629873619115 0.000852008439136243 0.164484201062998 0.650310662056234 miRNATAP -0.155803257284952 0.0327975831754687 NA NA NA hsa-miR-365a-3p PIK3R3 -1.15011003491084 0.00787110785444098 0.164484201062998 0.650310662056234 MirTarget -0.285141012391436 2.01968996754043e-06 NA NA NA hsa-miR-429 PIK3R3 1.86385884044684 0.00726080911989418 0.164484201062998 0.650310662056234 miRNATAP -0.118654139496878 0.00166778756395385 NA NA NA hsa-miR-92a-3p PIK3R3 -0.417284456385998 0.14690346065742 0.164484201062998 0.650310662056234 MirTarget;miRNATAP -0.335472291600353 0.000346376261360879 NA NA NA hsa-miR-96-5p PIK3R3 -0.14300109523641 0.834020197937914 0.164484201062998 0.650310662056234 mirMAP -0.18430263212422 1.2901616132214e-06 NA NA NA hsa-miR-107 PIK3R5 0.0358151350299583 0.899122490641298 -1.90515423968497 0.00299174608751457 miRanda -0.517551219290911 0.00277116217725851 NA NA NA hsa-miR-182-5p PIK3R5 0.193824666419893 0.730295924168823 -1.90515423968497 0.00299174608751457 MirTarget -0.498179642262328 1.02691686903097e-09 NA NA NA hsa-miR-642a-5p PIK3R5 -0.420667175766553 0.566119566077011 -1.90515423968497 0.00299174608751457 MirTarget -0.15094342708358 0.0204399403086404 NA NA NA hsa-let-7a-3p PPP3CA -0.95056529442537 0.00672174661147133 0.330525305359583 0.167062701753026 MirTarget;miRNATAP -0.146746998073016 0.00330247355585136 NA NA NA hsa-let-7g-5p PPP3CA -0.81305426635392 0.0157922690810057 0.330525305359583 0.167062701753026 miRNATAP -0.131030913702295 0.0123591070241553 NA NA NA hsa-miR-3065-3p PPP3CA 0.919910284231864 0.149524981714537 0.330525305359583 0.167062701753026 miRNATAP -0.0814981486181097 0.00276649562875777 NA NA NA hsa-miR-3065-5p PPP3CA 0.744542127327022 0.29683696958743 0.330525305359583 0.167062701753026 mirMAP;miRNATAP -0.0671167576597851 0.00595883451906168 NA NA NA hsa-miR-30c-5p PPP3CA -0.877497703999593 0.00776562825190586 0.330525305359583 0.167062701753026 miRNATAP -0.193738711247651 0.000254226436770353 NA NA NA hsa-miR-338-5p PPP3CA 0.336440913368409 0.532935762698486 0.330525305359583 0.167062701753026 miRNATAP -0.0941531374752457 0.00365482190147266 NA NA NA hsa-miR-33a-3p PPP3CA -1.71203223338714 0.000344436075634206 0.330525305359583 0.167062701753026 MirTarget;mirMAP;miRNATAP -0.0857953929179268 0.0207026407776021 NA NA NA hsa-miR-340-5p PPP3CA -0.873554108779771 0.0362049958643107 0.330525305359583 0.167062701753026 mirMAP -0.177208739566547 1.83514212990389e-05 NA NA NA hsa-miR-3607-3p PPP3CA -0.0996014475610343 0.818274259996261 0.330525305359583 0.167062701753026 MirTarget;mirMAP;miRNATAP -0.100348904235193 0.0136058731077984 NA NA NA hsa-miR-3653-3p PPP3CA -0.74933271118907 0.166396602670871 0.330525305359583 0.167062701753026 MirTarget -0.082036181653987 0.0117973173543683 NA NA NA hsa-miR-543 PPP3CA -1.03495265003894 0.0713462149984802 0.330525305359583 0.167062701753026 miRNATAP -0.0684533001690172 0.0257969303505266 NA NA NA hsa-miR-582-5p PPP3CA -0.241398739931134 0.638696591630038 0.330525305359583 0.167062701753026 miRNATAP -0.06799007449885 0.0471110057649287 NA NA NA hsa-miR-590-3p PPP3CA -0.921957466414335 0.0345620969748757 0.330525305359583 0.167062701753026 miRanda;mirMAP -0.0993765951025309 0.013337594776215 NA NA NA hsa-miR-628-3p PPP3CA -1.91638836103701 0.00403880122996397 0.330525305359583 0.167062701753026 PITA -0.0750525006922222 0.00391099695069961 NA NA NA hsa-miR-664a-3p PPP3CA -0.548519235569408 0.0680199398699682 0.330525305359583 0.167062701753026 mirMAP -0.214243610993067 0.000261217733985044 NA NA NA hsa-miR-7-1-3p PPP3CA -0.729687864305395 0.0834004484481893 0.330525305359583 0.167062701753026 MirTarget;mirMAP -0.112929449653803 0.00665828443610592 NA NA NA hsa-miR-96-5p PPP3CA -0.14300109523641 0.834020197937914 0.330525305359583 0.167062701753026 TargetScan -0.0592083008377867 0.0209850907711826 NA NA NA hsa-miR-146b-5p PPP3CB -1.18658780090466 0.0132247381969501 -0.262110945990165 0.20004630081009 miRanda -0.0985209307636428 0.00140065319472961 NA NA NA hsa-miR-30a-5p PPP3CB -0.588553206289925 0.175311638663077 -0.262110945990165 0.20004630081009 miRNATAP -0.106486657858805 0.0019199278858696 NA NA NA hsa-miR-424-5p PPP3CB -1.97114987995747 4.36503991925857e-07 -0.262110945990165 0.20004630081009 miRNATAP -0.0955536363786745 0.0103273500596395 NA NA NA hsa-miR-429 PPP3CB 1.86385884044684 0.00726080911989418 -0.262110945990165 0.20004630081009 miRanda -0.0751029170585059 0.000359591834050239 NA NA NA hsa-miR-450b-5p PPP3CB -0.947307681071554 0.0182365957775615 -0.262110945990165 0.20004630081009 MirTarget;PITA;miRNATAP -0.137670815639391 0.000184752241943926 NA NA NA hsa-miR-452-5p PPP3CB -0.155854942382797 0.727558997190393 -0.262110945990165 0.20004630081009 MirTarget;miRNATAP -0.195405070611779 1.22822748648958e-09 NA NA NA hsa-miR-502-3p PPP3CC -0.727559828010508 0.036178842243285 -0.516838489107435 0.0917882327355311 MirTarget;PITA;miRNATAP -0.144096574160387 0.028042800432177 NA NA NA hsa-miR-30b-5p PPP3R1 -0.68249444596921 0.0731627218334145 -0.0437836322428717 0.758726770965777 MirTarget -0.0967536609185231 0.000299816699098445 NA NA NA hsa-miR-30c-5p PPP3R1 -0.877497703999593 0.00776562825190586 -0.0437836322428717 0.758726770965777 MirTarget;miRNATAP -0.09011651266888 0.00380600352258944 NA NA NA hsa-miR-340-5p PPP3R1 -0.873554108779771 0.0362049958643107 -0.0437836322428717 0.758726770965777 mirMAP -0.0589980082194434 0.0163630443518498 NA NA NA hsa-miR-501-3p PPP3R1 -1.02561651155797 0.004055228716503 -0.0437836322428717 0.758726770965777 miRNATAP -0.0626867184366295 0.0292785073174545 NA NA NA hsa-miR-532-3p PPP3R1 -0.736090840140927 0.0634876924080901 -0.0437836322428717 0.758726770965777 miRNAWalker2_validate -0.057888501571973 0.0256449551395922 NA NA NA hsa-miR-582-5p PPP3R1 -0.241398739931134 0.638696591630038 -0.0437836322428717 0.758726770965777 MirTarget;PITA -0.0633924503941086 0.0013866537349124 NA NA NA hsa-miR-590-3p PPP3R1 -0.921957466414335 0.0345620969748757 -0.0437836322428717 0.758726770965777 miRanda;mirMAP -0.0566958603092412 0.0156596471766786 NA NA NA hsa-miR-7-1-3p PPP3R1 -0.729687864305395 0.0834004484481893 -0.0437836322428717 0.758726770965777 MirTarget -0.0691191262946656 0.00441362075446162 NA NA NA hsa-miR-196b-5p PRKACA 1.32792171126529 0.198066738241767 -0.299107082126354 0.0702421309467554 miRNAWalker2_validate -0.0760877785008404 3.41782982210731e-12 NA NA NA hsa-miR-365a-3p PRKACA -1.15011003491084 0.00787110785444098 -0.299107082126354 0.0702421309467554 miRNAWalker2_validate -0.0874144970950869 0.00146401204189702 NA NA NA hsa-miR-625-5p PRKACA -0.669707593941566 0.139101209005415 -0.299107082126354 0.0702421309467554 MirTarget -0.0601560669580419 0.0236688738824744 NA NA NA hsa-let-7a-3p PRKACB -0.95056529442537 0.00672174661147133 -0.0358595711129315 0.931791799041955 MirTarget;mirMAP;miRNATAP -0.247525554720969 0.00485871314778818 NA NA NA hsa-let-7d-3p PRKACB -0.546395697994207 0.0467385758062809 -0.0358595711129315 0.931791799041955 MirTarget -0.229727257950349 0.0455237514549732 NA NA NA hsa-let-7f-1-3p PRKACB -0.472422697135249 0.233118541405241 -0.0358595711129315 0.931791799041955 MirTarget;mirMAP -0.307357125419048 7.27853970219616e-05 NA NA NA hsa-miR-141-3p PRKACB 1.13131842772144 0.0966666388085424 -0.0358595711129315 0.931791799041955 MirTarget;TargetScan;miRNATAP -0.107368506045179 0.0170340573721758 NA NA NA hsa-miR-16-2-3p PRKACB -1.02821208937232 0.00734958396812714 -0.0358595711129315 0.931791799041955 mirMAP -0.25819510129563 0.00121899661506282 NA NA NA hsa-miR-17-5p PRKACB -0.667512721923102 0.0423050196597589 -0.0358595711129315 0.931791799041955 TargetScan -0.321063400462377 0.000635077317675195 NA NA NA hsa-miR-18a-5p PRKACB -1.17872230313757 0.0043629711019433 -0.0358595711129315 0.931791799041955 miRNATAP -0.233815706853874 0.0015386049576351 NA NA NA hsa-miR-193a-3p PRKACB -0.80533615405494 0.0191233168468354 -0.0358595711129315 0.931791799041955 miRanda -0.214961382858945 0.0172604447940358 NA NA NA hsa-miR-19a-3p PRKACB -1.39804789764109 0.00390589133951138 -0.0358595711129315 0.931791799041955 MirTarget;miRNATAP -0.232868506661778 0.000190119769489388 NA NA NA hsa-miR-19b-3p PRKACB -1.3861807379685 0.00102515671649667 -0.0358595711129315 0.931791799041955 miRNAWalker2_validate;MirTarget;miRNATAP -0.316793996487478 8.20962800317405e-06 NA NA NA hsa-miR-2110 PRKACB 0.0510292996505832 0.945835422414723 -0.0358595711129315 0.931791799041955 MirTarget -0.107963525270065 0.0291327186516258 NA NA NA hsa-miR-339-5p PRKACB -0.916407842972803 0.0433475651700471 -0.0358595711129315 0.931791799041955 miRanda -0.194542395053575 0.00403938275862535 NA NA NA hsa-miR-3613-3p PRKACB -0.973312457081501 0.056610643444148 -0.0358595711129315 0.931791799041955 MirTarget;mirMAP -0.145724215613137 0.0186921890215257 NA NA NA hsa-miR-362-3p PRKACB -1.20829972287608 0.012574092123476 -0.0358595711129315 0.931791799041955 PITA;miRanda;miRNATAP -0.132243426352266 0.0387737780143297 NA NA NA hsa-miR-93-5p PRKACB -0.468459476414832 0.131463449813313 -0.0358595711129315 0.931791799041955 miRNAWalker2_validate -0.319428721534143 0.00143955586468539 NA NA NA hsa-miR-96-5p PRKACB -0.14300109523641 0.834020197937914 -0.0358595711129315 0.931791799041955 miRNATAP -0.163739649147205 0.000240720286210279 NA NA NA hsa-miR-10a-3p PRKAR1A -0.279844305202879 0.538406840309486 -0.188644619252244 0.469673683330986 miRNATAP -0.15035924490675 0.000333712276187158 NA NA NA hsa-miR-155-5p PRKAR1A -1.43184489211345 0.00780837893756083 -0.188644619252244 0.469673683330986 miRNAWalker2_validate -0.0870853691448467 0.0133539401028745 NA NA NA hsa-miR-16-2-3p PRKAR1A -1.02821208937232 0.00734958396812714 -0.188644619252244 0.469673683330986 mirMAP -0.207140445160108 2.37165243053511e-05 NA NA NA hsa-miR-192-5p PRKAR1A 2.0972919255143 0.00232678828970491 -0.188644619252244 0.469673683330986 miRNAWalker2_validate -0.0765264665741022 0.00500492191464934 NA NA NA hsa-miR-200b-3p PRKAR1A 1.84496256556404 0.00297111610556856 -0.188644619252244 0.469673683330986 TargetScan -0.0877208840780719 0.00375780332525093 NA NA NA hsa-miR-215-5p PRKAR1A 3.0713645183039 0.00157974555130209 -0.188644619252244 0.469673683330986 miRNAWalker2_validate -0.0661034138008011 0.000554452040603498 NA NA NA hsa-miR-25-3p PRKAR1A -0.605277482359428 0.0245838382877904 -0.188644619252244 0.469673683330986 miRNAWalker2_validate -0.158474051309847 0.0290679981397742 NA NA NA hsa-miR-30a-5p PRKAR1A -0.588553206289925 0.175311638663077 -0.188644619252244 0.469673683330986 mirMAP -0.116411516309904 0.00829322924761353 NA NA NA hsa-miR-30b-5p PRKAR1A -0.68249444596921 0.0731627218334145 -0.188644619252244 0.469673683330986 mirMAP -0.131468036184607 0.00908895504863934 NA NA NA hsa-miR-30c-5p PRKAR1A -0.877497703999593 0.00776562825190586 -0.188644619252244 0.469673683330986 mirMAP -0.127138334781838 0.0295746476961268 NA NA NA hsa-miR-34c-5p PRKAR1A -0.0182044536033139 0.971130549817106 -0.188644619252244 0.469673683330986 miRanda -0.0848317294539396 0.0265572498921187 NA NA NA hsa-miR-429 PRKAR1A 1.86385884044684 0.00726080911989418 -0.188644619252244 0.469673683330986 PITA;miRanda;miRNATAP -0.08124749104554 0.00269817147225354 NA NA NA hsa-miR-96-5p PRKAR1A -0.14300109523641 0.834020197937914 -0.188644619252244 0.469673683330986 miRNAWalker2_validate;TargetScan;miRNATAP -0.0582965762630486 0.0373710462077066 NA NA NA hsa-let-7a-3p PRKAR2A -0.95056529442537 0.00672174661147133 -0.0343390048377326 0.946834265250298 mirMAP -0.368866890160844 0.0006059979671929 NA NA NA hsa-miR-17-5p PRKAR2A -0.667512721923102 0.0423050196597589 -0.0343390048377326 0.946834265250298 mirMAP -0.230502399600671 0.0485979581858924 NA NA NA hsa-miR-20a-5p PRKAR2A -0.39483820331792 0.269587643143535 -0.0343390048377326 0.946834265250298 mirMAP -0.30254480506826 0.00463817392299961 NA NA NA hsa-miR-21-5p PRKAR2A 0.313529032828654 0.492407646988864 -0.0343390048377326 0.946834265250298 mirMAP -0.171488857013472 0.0401151873681067 NA NA NA hsa-miR-26b-5p PRKAR2A -1.21629873619115 0.000852008439136243 -0.0343390048377326 0.946834265250298 mirMAP -0.338726057084231 0.000994002663536193 NA NA NA hsa-miR-32-5p PRKAR2A -1.1697502932723 0.00457026320106483 -0.0343390048377326 0.946834265250298 mirMAP -0.386088872558341 1.80093157633278e-05 NA NA NA hsa-miR-3913-5p PRKAR2A -0.142147035632342 0.687886997061968 -0.0343390048377326 0.946834265250298 mirMAP -0.281882038118288 0.00952363260188741 NA NA NA hsa-let-7a-3p PRKAR2B -0.95056529442537 0.00672174661147133 -1.53560766123188 0.0112015275806444 mirMAP -0.318957965445603 0.0131688551551058 NA NA NA hsa-miR-200b-3p PRKAR2B 1.84496256556404 0.00297111610556856 -1.53560766123188 0.0112015275806444 TargetScan -0.307717861542972 1.17812262170443e-05 NA NA NA hsa-miR-200c-3p PRKAR2B 1.55610325614114 0.0126526013557324 -1.53560766123188 0.0112015275806444 miRNATAP -0.160452637164676 0.0248366116868165 NA NA NA hsa-miR-429 PRKAR2B 1.86385884044684 0.00726080911989418 -1.53560766123188 0.0112015275806444 PITA;miRanda;miRNATAP -0.227834824504585 0.000327699236204097 NA NA NA hsa-miR-452-5p PRKAR2B -0.155854942382797 0.727558997190393 -1.53560766123188 0.0112015275806444 miRNATAP -0.275692954067654 0.00627356085142745 NA NA NA hsa-miR-92a-3p PRKAR2B -0.417284456385998 0.14690346065742 -1.53560766123188 0.0112015275806444 miRNATAP -0.532114366500985 0.000790134758066446 NA NA NA hsa-miR-103a-2-5p PRKX -2.05541485118484 0.00116353312692819 -0.870443233961537 0.0182172553055692 mirMAP -0.111247829039464 0.0103349781636558 NA NA NA hsa-miR-128-3p PRKX 0.0342813501565651 0.921232054277409 -0.870443233961537 0.0182172553055692 MirTarget -0.323245956314873 3.95572423906869e-05 NA NA NA hsa-miR-129-5p PRKX 1.01348286569596 0.367116067584743 -0.870443233961537 0.0182172553055692 miRanda;mirMAP -0.0864171231334782 0.000298661594457871 NA NA NA hsa-miR-148b-3p PRKX -0.0990745204340264 0.77230139028333 -0.870443233961537 0.0182172553055692 MirTarget -0.428731988454087 4.30906522271011e-08 NA NA NA hsa-miR-148b-5p PRKX -0.00680803632441723 0.990051364022285 -0.870443233961537 0.0182172553055692 mirMAP -0.170261804879098 0.000604758022928918 NA NA NA hsa-miR-16-1-3p PRKX -0.616362749214893 0.123693741249334 -0.870443233961537 0.0182172553055692 MirTarget -0.198381362423191 0.00367570276649571 NA NA NA hsa-miR-181c-5p PRKX 0.391426557741086 0.30540281172147 -0.870443233961537 0.0182172553055692 mirMAP -0.312015758333234 1.03975971244467e-05 NA NA NA hsa-miR-200a-5p PRKX 2.64896699149716 1.30695788228742e-05 -0.870443233961537 0.0182172553055692 mirMAP -0.130125235086126 0.00282099576207377 NA NA NA hsa-miR-200b-5p PRKX 0.86104461173291 0.183273431475269 -0.870443233961537 0.0182172553055692 mirMAP -0.118000765868512 0.0152338778788755 NA NA NA hsa-miR-29b-3p PRKX -0.392267406583841 0.343581862655996 -0.870443233961537 0.0182172553055692 mirMAP -0.183478037325332 0.00554581877229883 NA NA NA hsa-miR-3065-5p PRKX 0.744542127327022 0.29683696958743 -0.870443233961537 0.0182172553055692 mirMAP -0.160593190694966 1.80131863622644e-05 NA NA NA hsa-miR-323b-3p PRKX -0.893427137441785 0.288815437550969 -0.870443233961537 0.0182172553055692 mirMAP -0.117003679537924 0.000244663513121305 NA NA NA hsa-miR-330-3p PRKX 0.226896608253308 0.63792060187889 -0.870443233961537 0.0182172553055692 MirTarget -0.174900521550622 0.001968325392895 NA NA NA hsa-miR-33b-5p PRKX 0.621849465135339 0.329304820187453 -0.870443233961537 0.0182172553055692 mirMAP -0.136764768713277 0.00175870591551704 NA NA NA hsa-miR-375 PRKX 2.45956739868952 0.0171124871214617 -0.870443233961537 0.0182172553055692 miRNAWalker2_validate;miRanda -0.0647309452710802 0.0131934721989017 NA NA NA hsa-miR-409-3p PRKX -0.551546037982088 0.292612111819183 -0.870443233961537 0.0182172553055692 mirMAP -0.173430729980549 0.000798386712197044 NA NA NA hsa-miR-421 PRKX -0.177803877528689 0.691941942432956 -0.870443233961537 0.0182172553055692 miRanda -0.188308915288382 0.00214852307502038 NA NA NA hsa-miR-495-3p PRKX -0.819711095165138 0.0930619218141869 -0.870443233961537 0.0182172553055692 MirTarget -0.155188108299427 0.00537439859551613 NA NA NA hsa-miR-539-5p PRKX -0.736460955018657 0.259965401085259 -0.870443233961537 0.0182172553055692 mirMAP -0.130936516977934 0.00155569736698365 NA NA NA hsa-miR-935 PRKX 0.465382984103895 0.635211345947778 -0.870443233961537 0.0182172553055692 mirMAP -0.120324184267983 2.95149800403291e-05 NA NA NA hsa-miR-96-5p PRKX -0.14300109523641 0.834020197937914 -0.870443233961537 0.0182172553055692 mirMAP -0.114905466009477 0.00387293040577742 NA NA NA hsa-miR-1224-5p RELA 1.83900215224088 0.106580080531242 0.0807323662009924 0.694804791982396 mirMAP -0.0924355939791646 1.56495895774076e-13 NA NA NA hsa-miR-186-5p RELA -0.76553299921128 0.00203425234898652 0.0807323662009924 0.694804791982396 MirTarget -0.171815020507979 0.0052486901043715 NA NA NA hsa-miR-30e-5p RELA -0.989157025063461 0.00041808608143741 0.0807323662009924 0.694804791982396 miRNAWalker2_validate -0.130045709237435 0.0158278347806851 NA NA NA hsa-miR-324-5p RELA -0.993343053719004 0.00956564321262937 0.0807323662009924 0.694804791982396 miRNAWalker2_validate;miRanda -0.135653325662411 0.000469703189822543 NA NA NA hsa-miR-330-5p RELA 0.647187634039027 0.0863451847130066 0.0807323662009924 0.694804791982396 miRanda -0.149007261133817 0.000163217106319506 NA NA NA hsa-miR-421 RELA -0.177803877528689 0.691941942432956 0.0807323662009924 0.694804791982396 miRanda -0.155686916253904 2.58470576438263e-06 NA NA NA hsa-miR-7-5p RELA 0.818434078643802 0.510587133222615 0.0807323662009924 0.694804791982396 miRNAWalker2_validate;MirTarget -0.0915720608137987 2.21973070330172e-12 27203220 Importantly the effects of miR-7-5p on melanoma cell growth cell cycle migration and invasion were recapitulated by RelA knockdown melanoma hsa-miR-769-5p RELA -0.221361941699318 0.444319261990614 0.0807323662009924 0.694804791982396 miRNATAP -0.2626431934644 3.50020268290226e-07 NA NA NA hsa-miR-125a-3p RIPK1 0.430730138982692 0.360719040028155 -0.149562499803165 0.373389433935841 miRanda -0.106216677398358 3.09945188711407e-05 NA NA NA hsa-miR-429 TNF 1.86385884044684 0.00726080911989418 -1.97490684298883 0.00863397035883855 miRNATAP -0.199922768439973 0.0119992327895754 NA NA NA hsa-miR-129-5p TNFRSF10A 1.01348286569596 0.367116067584743 0.369106866417393 0.557352061244171 miRanda -0.254804168788955 6.40231052682925e-11 NA NA NA hsa-miR-16-5p TNFRSF10A -1.02296420363147 0.000327333184982762 0.369106866417393 0.557352061244171 miRNAWalker2_validate -0.402782913611203 0.0139423745911143 NA NA NA hsa-miR-3065-5p TNFRSF10B 0.744542127327022 0.29683696958743 0.0491581222898079 0.910647687622197 mirMAP -0.148900813386594 0.000854195227241018 NA NA NA hsa-miR-30c-1-3p TNFRSF10B -0.910239914572912 0.0580802814814516 0.0491581222898079 0.910647687622197 MirTarget -0.185903102091518 0.00861186286552069 NA NA NA hsa-miR-331-3p TNFRSF10B -0.39836136041646 0.233286681286756 0.0491581222898079 0.910647687622197 miRNAWalker2_validate -0.192966244044645 0.0489897104574389 NA NA NA hsa-miR-340-5p TNFRSF10B -0.873554108779771 0.0362049958643107 0.0491581222898079 0.910647687622197 miRNAWalker2_validate -0.21327133513057 0.00571964857222743 NA NA NA hsa-miR-3607-3p TNFRSF10B -0.0996014475610343 0.818274259996261 0.0491581222898079 0.910647687622197 mirMAP -0.154443138059093 0.0393711598856551 NA NA NA hsa-miR-496 TNFRSF10B -0.263423110562247 0.668883492994483 0.0491581222898079 0.910647687622197 miRanda -0.252104299750974 7.51808871747203e-07 NA NA NA hsa-miR-590-5p TNFRSF10B -0.984421368732497 0.00533663360221062 0.0491581222898079 0.910647687622197 miRanda -0.200157656812406 0.0287935157650022 NA NA NA hsa-miR-330-5p TNFRSF10C 0.647187634039027 0.0863451847130066 -0.0225160970183664 0.965975639258729 miRanda -0.284824640715565 0.00588527638743956 NA NA NA hsa-miR-361-5p TNFRSF10C -0.298789197467371 0.188640742693303 -0.0225160970183664 0.965975639258729 miRanda -0.370289649752483 0.0381542810846558 NA NA NA hsa-miR-139-5p TNFRSF10D -1.63574949154462 0.00653778531863944 0.296098384512509 0.579932925737218 miRanda -0.279728048071554 1.10992522380204e-05 NA NA NA hsa-miR-335-5p TNFRSF10D -0.913728460165869 0.0568330413961764 0.296098384512509 0.579932925737218 miRNAWalker2_validate -0.249393406638403 0.00225341607767384 NA NA NA hsa-miR-340-5p TNFRSF10D -0.873554108779771 0.0362049958643107 0.296098384512509 0.579932925737218 mirMAP -0.248846329468348 0.00843504754347726 NA NA NA hsa-miR-496 TNFRSF10D -0.263423110562247 0.668883492994483 0.296098384512509 0.579932925737218 miRanda -0.279798946779276 8.10511918472683e-06 NA NA NA hsa-miR-7-1-3p TNFRSF10D -0.729687864305395 0.0834004484481893 0.296098384512509 0.579932925737218 mirMAP -0.318189896891399 0.00062454736071909 NA NA NA hsa-miR-29c-3p TNFRSF1A -0.133603914094895 0.743610228811317 0.303136977837724 0.222693812736943 MirTarget;miRNATAP -0.157759438517068 0.000396428101106714 NA NA NA hsa-miR-129-5p TNFSF10 1.01348286569596 0.367116067584743 -0.505193303094384 0.225690368157762 miRanda -0.0865107315789738 0.0013569202713329 NA NA NA hsa-miR-137 TNFSF10 -0.0787835496950151 0.930521869365511 -0.505193303094384 0.225690368157762 miRanda -0.0892170251626362 0.0121019735570632 NA NA NA hsa-miR-139-5p TNFSF10 -1.63574949154462 0.00653778531863944 -0.505193303094384 0.225690368157762 miRanda -0.194019316491098 0.000101619713054016 NA NA NA hsa-miR-361-5p TNFSF10 -0.298789197467371 0.188640742693303 -0.505193303094384 0.225690368157762 miRanda -0.646383246279511 2.73858621616591e-06 NA NA NA hsa-miR-3613-3p TNFSF10 -0.973312457081501 0.056610643444148 -0.505193303094384 0.225690368157762 mirMAP -0.1316587985653 0.0333746669900571 NA NA NA hsa-miR-98-5p TNFSF10 -0.2176359368719 0.422768546610498 -0.505193303094384 0.225690368157762 miRNAWalker2_validate -0.588450604414359 1.89749778257629e-07 NA NA NA hsa-miR-125a-5p TP53 -0.306104092733909 0.370798466662369 -0.52799678906053 0.130661075040402 miRNAWalker2_validate;miRTarBase;miRanda -0.278339348800098 0.000225759076994646 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-421 TP53 -0.177803877528689 0.691941942432956 -0.52799678906053 0.130661075040402 miRanda -0.149316175927583 0.010142334822343 NA NA NA hsa-miR-324-3p TRADD -0.398222437776225 0.284591567984895 0.147257492908859 0.689265787831142 miRNATAP -0.498821094719735 4.74493566030825e-13 NA NA NA hsa-miR-543 TRADD -1.03495265003894 0.0713462149984802 0.147257492908859 0.689265787831142 miRanda -0.216636273904726 2.93473427945891e-06 NA NA NA hsa-miR-140-3p TRAF2 -0.399322174916632 0.209443645694375 0.0441842394161034 0.865111620806512 MirTarget -0.221569233424587 0.000230004278926919 NA NA NA hsa-miR-130a-5p XIAP -1.25302670373921 0.0116426772431465 0.170981700553299 0.377859792099543 MirTarget;miRNATAP -0.056786878316009 0.0487041638386854 24145606 Downregulation of miR 130a contributes to cisplatin resistance in ovarian cancer cells by targeting X linked inhibitor of apoptosis XIAP directly; Furthermore we found that miR-130a can directly target XIAP and participate in the regulation of apoptosis; The up-regulation of miR-130a led to a significant decrease in the XIAP mRNA levels and protein levels; Our findings suggested that miR-130a could play a role in the development of cisplatin resistance in ovarian cancer cell line A2780 at least in part by modulation of apoptosis via targeting XIAP drug resistance ovarian cancer hsa-miR-142-5p XIAP -1.83175166274452 0.00149435570575071 0.170981700553299 0.377859792099543 mirMAP;miRNATAP -0.0502433485383253 0.037810611986708 NA NA NA hsa-miR-146b-5p XIAP -1.18658780090466 0.0132247381969501 0.170981700553299 0.377859792099543 mirMAP;miRNATAP -0.072355796432469 0.0135959989147228 NA NA NA hsa-miR-16-2-3p XIAP -1.02821208937232 0.00734958396812714 0.170981700553299 0.377859792099543 mirMAP -0.0859091577340132 0.0196210318326662 NA NA NA hsa-miR-19a-3p XIAP -1.39804789764109 0.00390589133951138 0.170981700553299 0.377859792099543 mirMAP -0.0693324986452014 0.0164490760426912 NA NA NA hsa-miR-19b-3p XIAP -1.3861807379685 0.00102515671649667 0.170981700553299 0.377859792099543 mirMAP -0.0966120283330612 0.00345827006845956 NA NA NA hsa-miR-340-5p XIAP -0.873554108779771 0.0362049958643107 0.170981700553299 0.377859792099543 mirMAP;miRNATAP -0.0914921170452642 0.00681448748374266 NA NA NA