miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p ACTB 0.618599506841644 2.76973453058748e-05 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.263878009957968 1.64632068022263e-07 NA NA NA hsa-let-7g-3p ACTB 3.26398061402445 3.96263126107645e-25 -0.535801422758441 0.000459314156252532 miRNATAP -0.157828482219944 1.27542217216463e-12 NA NA NA hsa-miR-1307-3p ACTB 2.7570881639285 1.51270471508497e-23 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.172977096181006 3.87443067723834e-12 NA NA NA hsa-miR-16-5p ACTB 1.75824877145857 1.68592440033108e-16 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.141638633882294 2.43147349499537e-05 NA NA NA hsa-miR-320a ACTB 0.438165828017084 0.0390159073347133 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.222070967700543 1.26988287083172e-10 NA NA NA hsa-miR-324-5p ACTB 2.95683728155095 1.32960514360912e-20 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.15397390986434 1.35766571175256e-12 NA NA NA hsa-miR-378a-3p ACTB -0.10995720000828 0.716188270032681 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.180250833120146 4.83749854465663e-14 NA NA NA hsa-miR-484 ACTB 1.81844463411787 1.82951571230938e-15 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.170781380322726 4.03541322659563e-08 NA NA NA hsa-miR-590-3p ACTB 2.59289455139753 1.03200520972022e-21 -0.535801422758441 0.000459314156252532 miRanda -0.100943556200388 0.000158584006562112 NA NA NA hsa-miR-7-1-3p ACTB 1.84950311431067 1.25300363397654e-13 -0.535801422758441 0.000459314156252532 MirTarget -0.132690665264493 3.90684166113384e-06 NA NA NA hsa-miR-744-5p ACTB 1.48254348878737 3.23019501613577e-09 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.182519177096581 1.87837554260711e-10 NA NA NA hsa-miR-92a-3p ACTB 2.06460102658973 1.44784291084757e-19 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.179572915938495 5.38396620148296e-09 NA NA NA hsa-miR-93-3p ACTB 2.85383869771942 5.64481766902125e-23 -0.535801422758441 0.000459314156252532 miRNAWalker2_validate -0.205384375979903 1.5833972826667e-18 NA NA NA hsa-let-7a-3p AMOT 1.42015538786275 7.03375209382654e-13 -1.5101813515172 0.00384528008795201 mirMAP -0.607362810512887 1.12600841875315e-06 NA NA NA hsa-let-7b-3p AMOT 0.868207752019623 1.30460056774366e-05 -1.5101813515172 0.00384528008795201 mirMAP -0.578143608793239 4.88766453673297e-06 NA NA NA hsa-let-7b-5p AMOT 0.604314269683977 0.00140009936153214 -1.5101813515172 0.00384528008795201 MirTarget -0.373388949432571 0.00574281948077291 NA NA NA hsa-miR-203a-3p AMOT 3.12352008343999 9.49391438647189e-07 -1.5101813515172 0.00384528008795201 MirTarget -0.133394494587764 0.000649250323995256 NA NA NA hsa-miR-205-5p AMOT 4.1389800495524 2.05488295686453e-12 -1.5101813515172 0.00384528008795201 MirTarget;miRNATAP -0.302027637614162 1.14109844308491e-13 26239614 MicroRNA 205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression; In the present study miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region 3'-UTR of AMOT in breast cancer MCF-7 cells by luciferase assay; miR-205 and small interfering RNA siRNA-mediated AMOT-knockdown experiments revealed that miR-205 significantly inhibited the proliferation and the invasion of MCF-7 cells through a decrease in the expression of AMOT yet had no effect on apoptosis; Furthermore we observed that the overexpression of AMOT partially reversed the inhibitory effect of miR-205 on the growth and the invasion of MCF-7 cells; The data indicated that miR-205 regulated the proliferation and the invasion of breast cancer cells through suppression of AMOT expression at least partly; Therefore the disordered decreased expression of miR-205 and the resulting AMOT upregulation contributes to breast carcinogenesis and miR-205-AMOT represents a new potential therapeutic target for the treatment of breast carcinoma tumorigenesis breast cancer hsa-miR-21-3p AMOT 2.19296355304364 4.63665722759779e-15 -1.5101813515172 0.00384528008795201 mirMAP -0.485346396667163 2.14051185657743e-08 NA NA NA hsa-miR-22-3p AMOT 1.21545661147757 1.61670170137775e-13 -1.5101813515172 0.00384528008795201 MirTarget;miRNATAP -0.433407259494537 0.00433005929166161 NA NA NA hsa-miR-221-3p AMOT 0.451556679024397 0.0909808299917811 -1.5101813515172 0.00384528008795201 miRNAWalker2_validate -0.577116484074959 7.16051017754088e-10 NA NA NA hsa-miR-2355-3p AMOT 1.2671753520641 5.70559238344897e-05 -1.5101813515172 0.00384528008795201 MirTarget;miRNATAP -0.360188440735057 1.07194762867863e-05 NA NA NA hsa-miR-26b-5p AMOT 0.885393662798425 3.2116297961629e-06 -1.5101813515172 0.00384528008795201 MirTarget;miRNATAP -0.458605895748417 0.00057641537064055 NA NA NA hsa-miR-29a-3p AMOT -0.35074463683376 0.161238718982428 -1.5101813515172 0.00384528008795201 MirTarget;miRNATAP -0.305384223964004 0.00270591834320668 NA NA NA hsa-miR-29b-3p AMOT 1.65828197923813 1.02676780888141e-09 -1.5101813515172 0.00384528008795201 MirTarget;miRNATAP -0.266168357578692 0.00374694181923432 NA NA NA hsa-miR-34c-3p AMOT 2.41359195938096 3.46966584087088e-10 -1.5101813515172 0.00384528008795201 MirTarget;mirMAP -0.241958648909887 0.000289007793878246 NA NA NA hsa-miR-34c-5p AMOT 2.07190852984647 7.35776320806257e-08 -1.5101813515172 0.00384528008795201 miRanda -0.232920834745398 0.000752729848613869 NA NA NA hsa-miR-576-5p AMOT 2.20467023993664 3.4053475193793e-19 -1.5101813515172 0.00384528008795201 mirMAP -0.277921404893271 0.00499953973345483 NA NA NA hsa-miR-590-3p AMOT 2.59289455139753 1.03200520972022e-21 -1.5101813515172 0.00384528008795201 mirMAP -0.243754701050777 0.00791696722672722 NA NA NA hsa-miR-629-3p AMOT 2.36570947321815 1.33458201201618e-11 -1.5101813515172 0.00384528008795201 MirTarget -0.310318440937629 9.99779500116703e-05 NA NA NA hsa-miR-944 AMOT 2.91186649218281 1.31574753528144e-06 -1.5101813515172 0.00384528008795201 mirMAP;miRNATAP -0.375659903903163 5.80271240914789e-20 NA NA NA hsa-miR-125a-5p APC 0.599529391575274 0.0102300147180307 -0.603984431450045 0.000122196213200349 miRanda -0.206850857172122 1.35649172215922e-10 NA NA NA hsa-miR-148a-3p APC 1.26728238710376 2.52325607402829e-06 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.118159804157767 2.41472154629156e-05 NA NA NA hsa-miR-186-5p APC 1.47445398888668 3.0781726595413e-15 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.195857780898061 7.35879611668229e-07 NA NA NA hsa-miR-21-5p APC 2.73773305747971 1.38864982139576e-43 -0.603984431450045 0.000122196213200349 miRNAWalker2_validate -0.210735008738127 9.09045679037576e-10 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-320a APC 0.438165828017084 0.0390159073347133 -0.603984431450045 0.000122196213200349 miRanda -0.103841534148773 0.00418426564639978 NA NA NA hsa-miR-338-3p APC 0.453166438193782 0.144583389707558 -0.603984431450045 0.000122196213200349 miRanda -0.108366079373357 9.49384870738723e-06 NA NA NA hsa-miR-501-3p APC 1.83132758513743 1.10971547702065e-10 -0.603984431450045 0.000122196213200349 TargetScan -0.113665798109815 1.4428194665465e-05 NA NA NA hsa-miR-590-3p APC 2.59289455139753 1.03200520972022e-21 -0.603984431450045 0.000122196213200349 PITA;miRanda;mirMAP;miRNATAP -0.100123284836768 0.0002767508066816 NA NA NA hsa-miR-28-5p APC2 0.230152919654905 0.0742909586754846 0.382466786710938 0.250734891357193 mirMAP -0.367063763696686 0.00439410600608565 NA NA NA hsa-miR-429 AREG 4.48815175680773 2.44117492218206e-17 -1.82108928709305 0.00454782507843903 miRanda -0.192425822189951 0.000625024329953195 NA NA NA hsa-let-7a-3p AXIN2 1.42015538786275 7.03375209382654e-13 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.580881072981708 7.52786609329052e-09 NA NA NA hsa-let-7b-3p AXIN2 0.868207752019623 1.30460056774366e-05 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.466094148302635 5.47361078751581e-06 NA NA NA hsa-let-7g-3p AXIN2 3.26398061402445 3.96263126107645e-25 -1.6986287186272 5.56904404371908e-05 MirTarget -0.333037817887653 9.55083906918248e-08 NA NA NA hsa-miR-103a-3p AXIN2 1.44083190496858 1.53799939616416e-13 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.432944543888631 2.49508578477517e-05 NA NA NA hsa-miR-107 AXIN2 1.30977326593435 1.30372468603965e-11 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.497419239480003 1.65377519483307e-06 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-144-3p AXIN2 0.658119849508907 0.146943823997989 -1.6986287186272 5.56904404371908e-05 MirTarget -0.271648120794949 3.48662016244501e-09 NA NA NA hsa-miR-15a-5p AXIN2 2.34669284378787 1.69544424500258e-23 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.480955940416503 4.33519973886455e-09 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 1.57112623124278 9.14247846750597e-13 -1.6986287186272 5.56904404371908e-05 miRTarBase;MirTarget;miRNATAP -0.560514974548682 4.5066035821598e-10 NA NA NA hsa-miR-16-2-3p AXIN2 2.31623086727196 4.29838149388188e-20 -1.6986287186272 5.56904404371908e-05 mirMAP -0.591252000994373 5.59406157801316e-15 NA NA NA hsa-miR-16-5p AXIN2 1.75824877145857 1.68592440033108e-16 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.751187601216971 8.49686809333106e-17 NA NA NA hsa-miR-205-5p AXIN2 4.1389800495524 2.05488295686453e-12 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.215833874277093 8.14436018934996e-11 NA NA NA hsa-miR-221-3p AXIN2 0.451556679024397 0.0909808299917811 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.245163690159045 0.00148170922010665 NA NA NA hsa-miR-222-3p AXIN2 0.851783756239071 0.00266783568486918 -1.6986287186272 5.56904404371908e-05 miRNATAP -0.319516992304074 8.90127082603084e-06 NA NA NA hsa-miR-26b-3p AXIN2 2.18464160365372 2.11543189388328e-18 -1.6986287186272 5.56904404371908e-05 MirTarget -0.484074743403874 5.01575452903022e-10 NA NA NA hsa-miR-29a-5p AXIN2 1.46749674755271 3.34605004270294e-07 -1.6986287186272 5.56904404371908e-05 MirTarget -0.371370756814131 5.27889012104867e-07 NA NA NA hsa-miR-34a-5p AXIN2 1.9016323452565 1.43092834643601e-14 -1.6986287186272 5.56904404371908e-05 miRNAWalker2_validate;miRTarBase -0.316389522899683 8.52056660674017e-05 23624843 p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients colorectal cancer hsa-miR-3614-5p AXIN2 2.17736331059655 2.19144831318484e-08 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.268139148154882 4.79077962415622e-07 NA NA NA hsa-miR-424-5p AXIN2 1.61930224569578 1.89642549274994e-10 -1.6986287186272 5.56904404371908e-05 MirTarget;miRNATAP -0.26417909926508 0.000864498183223041 NA NA NA hsa-miR-429 AXIN2 4.48815175680773 2.44117492218206e-17 -1.6986287186272 5.56904404371908e-05 miRanda -0.108406747689685 0.00354861851668096 NA NA NA hsa-miR-590-3p AXIN2 2.59289455139753 1.03200520972022e-21 -1.6986287186272 5.56904404371908e-05 MirTarget;PITA;miRanda;miRNATAP -0.47289600145345 8.55966813825129e-11 NA NA NA hsa-miR-944 AXIN2 2.91186649218281 1.31574753528144e-06 -1.6986287186272 5.56904404371908e-05 MirTarget;PITA;miRNATAP -0.201429219843121 4.01001036442831e-09 NA NA NA hsa-miR-143-3p BBC3 -2.5789192793377 1.55518999614836e-14 1.11623140689651 3.60476730272011e-07 miRNATAP -0.130165583850532 2.4105347480111e-05 NA NA NA hsa-miR-221-3p BBC3 0.451556679024397 0.0909808299917811 1.11623140689651 3.60476730272011e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.157029927745573 9.37364503134878e-05 25585941;20813046 MiR 221 induced PUMA silencing mediates immune evasion of bladder cancer cells;MiR 221 and miR 222 target PUMA to induce cell survival in glioblastoma immune evasion;poor survival bladder cancer;glioblastoma hsa-miR-222-3p BBC3 0.851783756239071 0.00266783568486918 1.11623140689651 3.60476730272011e-07 miRNAWalker2_validate;miRNATAP -0.136078291771636 0.000312194570356401 20813046 MiR 221 and miR 222 target PUMA to induce cell survival in glioblastoma poor survival glioblastoma hsa-miR-10a-5p BIRC5 1.15016989191194 0.00372037233992369 3.86781496994262 3.62815734924518e-31 miRNAWalker2_validate -0.122559917660219 0.00501323157348866 NA NA NA hsa-miR-3065-5p BMP2 2.74629919868982 1.86846589298284e-08 -1.4585556992146 0.00276269620457527 mirMAP -0.271238334102083 2.81263836360285e-06 NA NA NA hsa-miR-142-3p BMP4 2.75247908790621 1.45636065474764e-12 -1.57065098962083 0.000133932493512791 PITA;miRanda -0.139369719608241 0.00541531782039283 NA NA NA hsa-miR-590-3p BMP4 2.59289455139753 1.03200520972022e-21 -1.57065098962083 0.000133932493512791 miRanda -0.366398585543619 3.213147138986e-07 NA NA NA hsa-miR-576-5p BMP5 2.20467023993664 3.4053475193793e-19 -4.52631327010929 8.652621809138e-11 mirMAP -0.455108363311804 0.000719254735006134 NA NA NA hsa-miR-590-3p BMP5 2.59289455139753 1.03200520972022e-21 -4.52631327010929 8.652621809138e-11 mirMAP -0.378335992480482 0.00244428676533185 NA NA NA hsa-miR-130b-3p BMP6 3.5350292994509 1.73934183852569e-27 -0.50213082357528 0.129852040956245 MirTarget -0.160881805826862 0.0004745109488921 NA NA NA hsa-miR-301a-3p BMP6 2.81024345929638 2.29784847962242e-17 -0.50213082357528 0.129852040956245 MirTarget -0.218492005642097 7.6576704866361e-06 NA NA NA hsa-miR-320a BMP6 0.438165828017084 0.0390159073347133 -0.50213082357528 0.129852040956245 PITA;miRanda -0.247741579467164 0.00111437088429099 NA NA NA hsa-miR-320b BMP6 1.55692969039548 1.41071034251915e-08 -0.50213082357528 0.129852040956245 PITA;miRanda -0.232557979098243 4.95120956708228e-05 NA NA NA hsa-miR-34c-5p BMP6 2.07190852984647 7.35776320806257e-08 -0.50213082357528 0.129852040956245 miRanda -0.11847860283684 0.00681491870697078 NA NA NA hsa-miR-454-3p BMP6 2.47234127820054 1.12878018736016e-21 -0.50213082357528 0.129852040956245 MirTarget -0.179262375804332 0.00317917125472434 NA NA NA hsa-miR-590-3p BMP6 2.59289455139753 1.03200520972022e-21 -0.50213082357528 0.129852040956245 mirMAP -0.18948662565478 0.00106147689407981 NA NA NA hsa-miR-590-5p BMP6 3.18300989862077 2.06813568597893e-26 -0.50213082357528 0.129852040956245 miRanda -0.185298256321475 0.000329323108000979 NA NA NA hsa-miR-338-3p BMP7 0.453166438193782 0.144583389707558 -1.77720755920917 0.028758021459053 miRanda -0.411479827858547 0.00118108686362591 NA NA NA hsa-miR-342-3p BMP7 1.49115144672245 1.43879249744621e-07 -1.77720755920917 0.028758021459053 miRNAWalker2_validate;miRTarBase;miRanda -0.564549946965806 3.57247612956533e-05 NA NA NA hsa-miR-30b-3p BMP8A 0.834142820354026 0.000972582820878813 1.41736177621035 1.68060292641289e-08 MirTarget -0.181506102948814 0.000207303144028512 NA NA NA hsa-miR-30d-3p BMP8A 0.977747550180601 4.3048212205381e-05 1.41736177621035 1.68060292641289e-08 MirTarget -0.209644722182892 4.46988132772963e-05 NA NA NA hsa-miR-30e-3p BMP8A -0.215663037684509 0.235375122783546 1.41736177621035 1.68060292641289e-08 MirTarget -0.330734323380831 1.3029240477641e-06 NA NA NA hsa-miR-423-5p BMP8A 0.963563145758616 9.86109015204915e-07 1.41736177621035 1.68060292641289e-08 MirTarget -0.28768488873678 3.67538714707699e-06 NA NA NA hsa-miR-140-5p BMPR1A 0.844753502512594 3.73722278438606e-05 -0.769696479269679 2.04474538839979e-07 miRanda -0.202151232698844 6.83112462517003e-09 NA NA NA hsa-miR-186-5p BMPR1A 1.47445398888668 3.0781726595413e-15 -0.769696479269679 2.04474538839979e-07 MirTarget -0.224056939288219 1.83929274683298e-09 NA NA NA hsa-miR-589-5p BMPR1A 1.71990116752371 8.310889042056e-14 -0.769696479269679 2.04474538839979e-07 MirTarget -0.117858616604392 0.000115436246469953 NA NA NA hsa-miR-942-5p BMPR1A 2.35195531153712 5.45059325728841e-16 -0.769696479269679 2.04474538839979e-07 MirTarget -0.135969732155585 1.06845135905673e-08 NA NA NA hsa-miR-101-3p BMPR1B 0.522819989585461 0.00375627731618038 0.0707965297684667 0.914043396353822 miRNATAP -0.90210571972084 2.80184826114495e-07 NA NA NA hsa-miR-125a-5p BMPR1B 0.599529391575274 0.0102300147180307 0.0707965297684667 0.914043396353822 MirTarget;miRNATAP -0.807051783523079 1.75213413272931e-09 NA NA NA hsa-miR-182-5p BMPR1B 3.53923166221814 5.07781258121574e-21 0.0707965297684667 0.914043396353822 MirTarget -0.352429426701482 9.54099393700212e-06 NA NA NA hsa-miR-205-5p BMPR1B 4.1389800495524 2.05488295686453e-12 0.0707965297684667 0.914043396353822 miRNATAP -0.145489854588743 0.00537234614703736 NA NA NA hsa-miR-26b-5p BMPR1B 0.885393662798425 3.2116297961629e-06 0.0707965297684667 0.914043396353822 mirMAP -0.53030485705377 0.00145841207417321 NA NA NA hsa-miR-330-3p BMPR1B 0.876747334239085 0.00073709016089703 0.0707965297684667 0.914043396353822 mirMAP -0.64524174638227 8.45898404828024e-08 NA NA NA hsa-miR-429 BMPR1B 4.48815175680773 2.44117492218206e-17 0.0707965297684667 0.914043396353822 miRNATAP -0.32745235892597 6.75303195574634e-09 NA NA NA hsa-miR-582-5p BMPR1B 0.609226359812689 0.032988717891497 0.0707965297684667 0.914043396353822 mirMAP;miRNATAP -0.2913092235054 0.00879653271190915 NA NA NA hsa-let-7a-3p BMPR2 1.42015538786275 7.03375209382654e-13 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.152599783592152 7.93471191590871e-06 NA NA NA hsa-let-7f-1-3p BMPR2 1.55054488387679 7.31326775537952e-11 -0.58530303628062 4.05328570423415e-05 MirTarget -0.120307970421237 4.01438554279305e-05 NA NA NA hsa-miR-103a-2-5p BMPR2 2.47599305985086 7.933028987326e-11 -0.58530303628062 4.05328570423415e-05 MirTarget -0.156735069522438 8.7398797773895e-16 NA NA NA hsa-miR-106a-5p BMPR2 2.48882002962836 1.99757727374521e-12 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.13439006659681 4.71463912179543e-13 NA NA NA hsa-miR-106b-5p BMPR2 2.46782146831112 1.36171495805632e-23 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.20224216578274 5.65419838003578e-15 NA NA NA hsa-miR-126-5p BMPR2 0.895338176458417 2.33372756450713e-05 -0.58530303628062 4.05328570423415e-05 mirMAP -0.165449066005832 3.2676073018839e-07 NA NA NA hsa-miR-1271-5p BMPR2 0.970418832993172 0.000609742584380688 -0.58530303628062 4.05328570423415e-05 mirMAP -0.118572818651164 1.01152665195014e-06 NA NA NA hsa-miR-128-3p BMPR2 1.63756041666078 6.79626586407187e-14 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.155559506127877 3.86430519746196e-07 NA NA NA hsa-miR-130a-3p BMPR2 2.02021855058359 1.26427102520415e-11 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.170876589923038 8.54902300867997e-15 NA NA NA hsa-miR-130b-3p BMPR2 3.5350292994509 1.73934183852569e-27 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.132480742234581 1.12126386981845e-11 NA NA NA hsa-miR-136-5p BMPR2 2.09637138292451 1.50140005592201e-10 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.102497292768817 5.91057010070874e-07 NA NA NA hsa-miR-148a-3p BMPR2 1.26728238710376 2.52325607402829e-06 -0.58530303628062 4.05328570423415e-05 mirMAP -0.116655579885245 4.16215411693408e-06 NA NA NA hsa-miR-148b-3p BMPR2 1.97815018171325 6.07715327281595e-26 -0.58530303628062 4.05328570423415e-05 mirMAP -0.217098539189951 2.81982996054712e-10 NA NA NA hsa-miR-16-2-3p BMPR2 2.31623086727196 4.29838149388188e-20 -0.58530303628062 4.05328570423415e-05 mirMAP -0.241072228557309 6.56045989506605e-22 NA NA NA hsa-miR-17-5p BMPR2 3.2710598467455 9.93128340539455e-27 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.207670381733977 5.53123576642946e-25 NA NA NA hsa-miR-181a-5p BMPR2 2.29556023480783 1.8138457900616e-21 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.162789789795827 1.63903044624448e-09 NA NA NA hsa-miR-181b-5p BMPR2 2.49307679431293 3.92829250217627e-20 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.123144226085464 3.57698509578988e-07 NA NA NA hsa-miR-181c-5p BMPR2 1.58587920618301 1.57506918816933e-10 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRNATAP -0.122880367144444 6.67276222281815e-06 NA NA NA hsa-miR-185-5p BMPR2 2.34016206907488 1.17481626642022e-26 -0.58530303628062 4.05328570423415e-05 MirTarget -0.206443321614726 1.4604662917038e-12 NA NA NA hsa-miR-186-5p BMPR2 1.47445398888668 3.0781726595413e-15 -0.58530303628062 4.05328570423415e-05 mirMAP -0.324362481564346 6.90612135973666e-21 NA NA NA hsa-miR-192-5p BMPR2 2.69002528723195 1.22990188194432e-16 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.128397743535831 1.9307144568072e-10 NA NA NA hsa-miR-19a-3p BMPR2 3.42309334186656 3.02671914353412e-28 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.217742883172278 6.6262310927576e-29 NA NA NA hsa-miR-19b-3p BMPR2 2.49529833021187 1.57028265846699e-23 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.277864569361708 1.50881970906485e-29 NA NA NA hsa-miR-20a-5p BMPR2 3.15577933619191 4.19753346442454e-25 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.212052258591281 9.32636588986309e-26 NA NA NA hsa-miR-21-5p BMPR2 2.73773305747971 1.38864982139576e-43 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.131652287320736 3.08798777679263e-05 NA NA NA hsa-miR-25-3p BMPR2 1.36472605225697 4.83790725935681e-11 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.250622353088396 3.88435226773423e-15 NA NA NA hsa-miR-26a-2-3p BMPR2 0.823520019989974 0.00017092160823769 -0.58530303628062 4.05328570423415e-05 mirMAP -0.160089489051874 3.84214898400944e-07 NA NA NA hsa-miR-26b-5p BMPR2 0.885393662798425 3.2116297961629e-06 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.170544930909617 2.42578893081629e-06 NA NA NA hsa-miR-29a-5p BMPR2 1.46749674755271 3.34605004270294e-07 -0.58530303628062 4.05328570423415e-05 mirMAP -0.147951331287937 2.48083220467992e-09 NA NA NA hsa-miR-301a-3p BMPR2 2.81024345929638 2.29784847962242e-17 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.18525048532623 8.92556176756374e-20 NA NA NA hsa-miR-30b-5p BMPR2 0.800822374912712 0.000133601914525413 -0.58530303628062 4.05328570423415e-05 mirMAP -0.208948854448395 1.25518734516915e-10 NA NA NA hsa-miR-30c-5p BMPR2 0.778774633108 0.000285599212429136 -0.58530303628062 4.05328570423415e-05 mirMAP -0.221901856860224 2.13739174130527e-12 NA NA NA hsa-miR-30d-5p BMPR2 0.675423997639582 0.00270618816039773 -0.58530303628062 4.05328570423415e-05 mirMAP -0.106831948440534 0.000526281245791836 NA NA NA hsa-miR-30e-5p BMPR2 1.23904909539663 1.35561917122157e-09 -0.58530303628062 4.05328570423415e-05 mirMAP -0.226767367157603 4.55367004734674e-12 NA NA NA hsa-miR-32-3p BMPR2 2.02436999565685 5.94091197945307e-09 -0.58530303628062 4.05328570423415e-05 mirMAP -0.142554817131472 7.47259006817624e-11 NA NA NA hsa-miR-32-5p BMPR2 2.34056473219422 6.24134585974322e-20 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.185360171623864 2.11849459894302e-13 NA NA NA hsa-miR-320a BMPR2 0.438165828017084 0.0390159073347133 -0.58530303628062 4.05328570423415e-05 mirMAP -0.114792800350135 0.000470262582947611 NA NA NA hsa-miR-320b BMPR2 1.55692969039548 1.41071034251915e-08 -0.58530303628062 4.05328570423415e-05 mirMAP -0.100895055393743 4.65320859022884e-05 NA NA NA hsa-miR-342-3p BMPR2 1.49115144672245 1.43879249744621e-07 -0.58530303628062 4.05328570423415e-05 PITA;miRanda;miRNATAP -0.187659669744693 1.0015406600685e-15 NA NA NA hsa-miR-342-5p BMPR2 1.74634624752902 3.89286511372155e-11 -0.58530303628062 4.05328570423415e-05 PITA -0.195566762253857 4.49851211238107e-15 NA NA NA hsa-miR-3607-3p BMPR2 2.68532138541128 5.66716351955047e-14 -0.58530303628062 4.05328570423415e-05 mirMAP;miRNATAP -0.119708962682516 2.74424001919374e-10 NA NA NA hsa-miR-361-5p BMPR2 0.971859117235239 5.30236555707088e-09 -0.58530303628062 4.05328570423415e-05 MirTarget;miRanda;mirMAP;miRNATAP -0.241826033261252 3.38904299290922e-09 NA NA NA hsa-miR-362-3p BMPR2 2.0756816987665 3.89026064579331e-12 -0.58530303628062 4.05328570423415e-05 MirTarget;PITA;miRanda;miRNATAP -0.201623668293698 2.30109419676209e-19 NA NA NA hsa-miR-374a-3p BMPR2 0.533309330504947 0.00192918429705142 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.241041299268692 1.85393256226074e-09 NA NA NA hsa-miR-374a-5p BMPR2 0.484615721953736 0.0042981729815149 -0.58530303628062 4.05328570423415e-05 mirMAP -0.175249946103084 2.03749633026624e-05 NA NA NA hsa-miR-374b-5p BMPR2 0.0654362503857184 0.722673188879465 -0.58530303628062 4.05328570423415e-05 mirMAP -0.154723029815258 4.57180644031775e-05 NA NA NA hsa-miR-378a-5p BMPR2 0.223456081148306 0.386368843153575 -0.58530303628062 4.05328570423415e-05 MirTarget -0.105826927414969 8.35359705651086e-05 NA NA NA hsa-miR-454-3p BMPR2 2.47234127820054 1.12878018736016e-21 -0.58530303628062 4.05328570423415e-05 MirTarget;miRNATAP -0.238011207160195 2.11723827812009e-21 NA NA NA hsa-miR-532-5p BMPR2 1.55697650978597 1.57884735535196e-11 -0.58530303628062 4.05328570423415e-05 PITA -0.238551867133178 4.45231582710634e-17 NA NA NA hsa-miR-590-3p BMPR2 2.59289455139753 1.03200520972022e-21 -0.58530303628062 4.05328570423415e-05 MirTarget;miRanda;mirMAP;miRNATAP -0.210351080269878 2.47174316977252e-18 NA NA NA hsa-miR-590-5p BMPR2 3.18300989862077 2.06813568597893e-26 -0.58530303628062 4.05328570423415e-05 MirTarget;PITA;miRNATAP -0.205931557990053 3.89024781095923e-22 NA NA NA hsa-miR-625-3p BMPR2 1.18769734290812 2.47200238827911e-06 -0.58530303628062 4.05328570423415e-05 mirMAP -0.158762143086924 3.48996581536411e-09 NA NA NA hsa-miR-628-5p BMPR2 0.799263053510813 2.28892357418044e-05 -0.58530303628062 4.05328570423415e-05 MirTarget;PITA;miRNATAP -0.152693375167128 3.14890533041555e-05 NA NA NA hsa-miR-629-5p BMPR2 2.10182419359635 1.51788571125757e-15 -0.58530303628062 4.05328570423415e-05 mirMAP -0.122690028995621 1.17900187204531e-06 NA NA NA hsa-miR-651-5p BMPR2 2.32951837918862 1.62508965949028e-11 -0.58530303628062 4.05328570423415e-05 MirTarget -0.142540412171573 3.95043275025226e-11 NA NA NA hsa-miR-671-5p BMPR2 2.97733652243246 1.21148452344738e-23 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.160465039608908 1.99277235532283e-12 NA NA NA hsa-miR-7-1-3p BMPR2 1.84950311431067 1.25300363397654e-13 -0.58530303628062 4.05328570423415e-05 mirMAP -0.210194689122166 1.01588158730921e-15 NA NA NA hsa-miR-769-5p BMPR2 1.82023760596845 9.6815886564134e-14 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.177508544106453 5.50412874459117e-11 NA NA NA hsa-miR-877-5p BMPR2 2.94916202082736 1.8151927276044e-13 -0.58530303628062 4.05328570423415e-05 MirTarget -0.112421242369306 1.5760150030228e-09 NA NA NA hsa-miR-92a-3p BMPR2 2.06460102658973 1.44784291084757e-19 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;miRNATAP -0.270169549134034 2.25203735602053e-22 NA NA NA hsa-miR-92b-3p BMPR2 1.20409245530001 3.41055816361655e-06 -0.58530303628062 4.05328570423415e-05 miRNATAP -0.131517451998029 5.64955467094799e-07 NA NA NA hsa-miR-93-3p BMPR2 2.85383869771942 5.64481766902125e-23 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate -0.18751024777473 1.09935783855603e-17 NA NA NA hsa-miR-93-5p BMPR2 3.03961860136032 1.11672209617395e-24 -0.58530303628062 4.05328570423415e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.193491063264994 5.44145207255781e-20 NA NA NA hsa-miR-193a-3p BTRC 1.60460546928078 2.86169793322984e-07 -0.199546019056698 0.103646726553756 MirTarget;miRanda -0.120133296395203 4.72730403880987e-11 NA NA NA hsa-miR-22-5p BTRC 1.88011544159252 1.63978222572222e-16 -0.199546019056698 0.103646726553756 miRNATAP -0.10241724919548 4.03610900116379e-05 NA NA NA hsa-miR-361-3p BTRC 1.07367425434318 1.73142774168958e-09 -0.199546019056698 0.103646726553756 MirTarget;PITA;miRNATAP -0.16327609888542 5.3557640072081e-07 NA NA NA hsa-miR-106a-5p CCND1 2.48882002962836 1.99757727374521e-12 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.278915751904438 2.46069960202024e-07 NA NA NA hsa-miR-15b-5p CCND1 1.57112623124278 9.14247846750597e-13 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.2743592470705 0.00190316455907807 NA NA NA hsa-miR-186-5p CCND1 1.47445398888668 3.0781726595413e-15 0.0828319966762319 0.840332435689448 mirMAP -0.319993507741074 0.0020448551843367 NA NA NA hsa-miR-193a-3p CCND1 1.60460546928078 2.86169793322984e-07 0.0828319966762319 0.840332435689448 MirTarget;PITA;miRanda -0.351734964348069 1.30056584701733e-08 NA NA NA hsa-miR-195-5p CCND1 -1.44753678070504 8.70594292149271e-09 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.232938095379387 0.00278406868271715 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-20b-5p CCND1 2.07706563022469 1.10107236083433e-05 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.250774310314038 8.20956147612201e-10 NA NA NA hsa-miR-340-5p CCND1 0.30282999308409 0.157744789519131 0.0828319966762319 0.840332435689448 mirMAP -0.529085780655826 9.29072904979919e-09 NA NA NA hsa-miR-374b-5p CCND1 0.0654362503857184 0.722673188879465 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;MirTarget -0.416222074203323 0.000132219455740898 NA NA NA hsa-miR-497-5p CCND1 0.0257087130056286 0.918145413833358 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.30773442281542 0.000110601843767413 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-7-1-3p CCND1 1.84950311431067 1.25300363397654e-13 0.0828319966762319 0.840332435689448 mirMAP -0.247700635127977 0.00138754391814163 NA NA NA hsa-miR-769-3p CCND1 2.19896922202687 5.69250370895053e-12 0.0828319966762319 0.840332435689448 mirMAP -0.231146561837838 0.000210475786569237 NA NA NA hsa-let-7a-3p CCND2 1.42015538786275 7.03375209382654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.440555668621489 2.14967330798537e-06 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7a-5p CCND2 0.618599506841644 2.76973453058748e-05 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.503238938401113 9.92586197811674e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.868207752019623 1.30460056774366e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.292600423696445 0.00203496813099611 NA NA NA hsa-let-7b-5p CCND2 0.604314269683977 0.00140009936153214 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372644945722985 0.000202758514128247 NA NA NA hsa-let-7e-5p CCND2 0.860104282510173 6.04758298373779e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.254279031336757 0.00390630067355032 NA NA NA hsa-let-7f-1-3p CCND2 1.55054488387679 7.31326775537952e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.349075249109793 1.19776506071246e-05 NA NA NA hsa-let-7f-5p CCND2 0.495648727272215 0.00355972741198794 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.395067035409999 0.000431247614557398 NA NA NA hsa-let-7g-5p CCND2 1.20061455355116 1.50237505511483e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.78482657734201 2.2934101130382e-13 NA NA NA hsa-miR-106a-5p CCND2 2.48882002962836 1.99757727374521e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.460265785003224 1.90572227650597e-20 NA NA NA hsa-miR-106b-5p CCND2 2.46782146831112 1.36171495805632e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.723802321113981 4.62852843641777e-26 NA NA NA hsa-miR-10b-3p CCND2 0.77597971642517 0.00264877454133753 -2.42747067684236 2.06814828958882e-10 mirMAP -0.299055149155965 4.03151748542262e-05 NA NA NA hsa-miR-130b-5p CCND2 2.9963110846538 1.98883029416455e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524276006004661 2.15252650149472e-24 NA NA NA hsa-miR-141-3p CCND2 5.02396127982626 2.19224509139725e-24 -2.42747067684236 2.06814828958882e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-151a-3p CCND2 1.24018761527407 1.08839919675408e-07 -2.42747067684236 2.06814828958882e-10 mirMAP -0.618872158164273 1.57062556462901e-15 NA NA NA hsa-miR-15a-5p CCND2 2.34669284378787 1.69544424500258e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.558385276567589 5.78612617845985e-14 NA NA NA hsa-miR-15b-5p CCND2 1.57112623124278 9.14247846750597e-13 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.814047353716774 1.36644748676197e-24 NA NA NA hsa-miR-16-2-3p CCND2 2.31623086727196 4.29838149388188e-20 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524415153934827 5.42085565840902e-14 NA NA NA hsa-miR-16-5p CCND2 1.75824877145857 1.68592440033108e-16 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRNATAP -0.624880555696101 7.5948593080299e-14 NA NA NA hsa-miR-17-5p CCND2 3.2710598467455 9.93128340539455e-27 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.576586035201243 5.39762569803648e-26 NA NA NA hsa-miR-181a-2-3p CCND2 2.19062681262366 3.81790102612782e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.371385706331271 5.48097191184985e-10 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-183-5p CCND2 4.19757025992371 4.79612296318304e-26 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.406097602561121 1.1832385157764e-21 NA NA NA hsa-miR-185-5p CCND2 2.34016206907488 1.17481626642022e-26 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.596214855521239 5.09732672184216e-14 NA NA NA hsa-miR-186-5p CCND2 1.47445398888668 3.0781726595413e-15 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.753228825405404 3.55444659312987e-15 NA NA NA hsa-miR-188-5p CCND2 2.52825126596644 6.78099435999778e-14 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.327199573697285 9.78244941189197e-09 NA NA NA hsa-miR-191-5p CCND2 2.30038190670664 9.93191704545938e-17 -2.42747067684236 2.06814828958882e-10 MirTarget -0.63056469865633 4.58280529094783e-24 NA NA NA hsa-miR-19a-3p CCND2 3.42309334186656 3.02671914353412e-28 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.478555105133488 2.03415225430867e-18 NA NA NA hsa-miR-19b-3p CCND2 2.49529833021187 1.57028265846699e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.644240893236217 5.93065810659583e-21 NA NA NA hsa-miR-200a-3p CCND2 4.59434485520731 6.38952518573476e-18 -2.42747067684236 2.06814828958882e-10 MirTarget -0.322639326506763 1.12744821991113e-23 NA NA NA hsa-miR-20a-5p CCND2 3.15577933619191 4.19753346442454e-25 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552675029838617 1.98133209896024e-23 NA NA NA hsa-miR-20b-5p CCND2 2.07706563022469 1.10107236083433e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.296015277168294 1.16933542500196e-14 NA NA NA hsa-miR-21-3p CCND2 2.19296355304364 4.63665722759779e-15 -2.42747067684236 2.06814828958882e-10 mirMAP -0.266420777851125 4.25531839718567e-05 NA NA NA hsa-miR-224-3p CCND2 1.87536386559317 6.15140969394846e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.234939524450716 1.27567539540633e-08 NA NA NA hsa-miR-26b-5p CCND2 0.885393662798425 3.2116297961629e-06 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.333191234288059 0.000785967313666436 NA NA NA hsa-miR-29b-3p CCND2 1.65828197923813 1.02676780888141e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.181452610770389 0.00800883535071036 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 2.81024345929638 2.29784847962242e-17 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.490714440601798 1.13987935585442e-18 NA NA NA hsa-miR-3065-3p CCND2 2.16221780121195 9.65525739884541e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.234083951058536 1.60505150894369e-06 NA NA NA hsa-miR-3065-5p CCND2 2.74629919868982 1.86846589298284e-08 -2.42747067684236 2.06814828958882e-10 mirMAP -0.236930159170796 2.73973057309239e-07 NA NA NA hsa-miR-30d-3p CCND2 0.977747550180601 4.3048212205381e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.514799428246913 2.69094766335815e-11 NA NA NA hsa-miR-30e-3p CCND2 -0.215663037684509 0.235375122783546 -2.42747067684236 2.06814828958882e-10 mirMAP -0.317748716556734 0.00256884077064715 NA NA NA hsa-miR-32-3p CCND2 2.02436999565685 5.94091197945307e-09 -2.42747067684236 2.06814828958882e-10 mirMAP -0.37065809204682 5.74913234109809e-10 NA NA NA hsa-miR-320a CCND2 0.438165828017084 0.0390159073347133 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.366959333753783 3.90012764364419e-05 NA NA NA hsa-miR-320b CCND2 1.55692969039548 1.41071034251915e-08 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.389495451202309 5.62361965191887e-09 NA NA NA hsa-miR-324-3p CCND2 2.08739139768981 3.11885987067952e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.569926030100518 1.57078270718816e-20 NA NA NA hsa-miR-331-5p CCND2 2.17414714166315 1.54547681391888e-18 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.55418360999634 4.24751797285043e-14 NA NA NA hsa-miR-335-5p CCND2 1.77247705492746 2.22457658872091e-06 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.196309653133352 7.59470226154717e-05 NA NA NA hsa-miR-33a-3p CCND2 1.72765312072219 1.51784443453521e-07 -2.42747067684236 2.06814828958882e-10 MirTarget -0.474892003832155 3.60158523540778e-15 NA NA NA hsa-miR-3607-3p CCND2 2.68532138541128 5.66716351955047e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.253991708738003 1.1264040881505e-06 NA NA NA hsa-miR-374b-3p CCND2 0.930487774873495 2.74420094310516e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.379294826109076 7.61411367904561e-06 NA NA NA hsa-miR-378a-3p CCND2 -0.10995720000828 0.716188270032681 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.264766627168263 2.14263562743039e-05 NA NA NA hsa-miR-423-5p CCND2 0.963563145758616 9.86109015204915e-07 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.681308347713645 2.78087673863117e-13 NA NA NA hsa-miR-424-5p CCND2 1.61930224569578 1.89642549274994e-10 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.208747216207423 0.00424259734488207 NA NA NA hsa-miR-429 CCND2 4.48815175680773 2.44117492218206e-17 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.316889169500172 1.77696184266368e-22 NA NA NA hsa-miR-450b-5p CCND2 1.69244418548325 1.68064054148881e-10 -2.42747067684236 2.06814828958882e-10 MirTarget;PITA;miRNATAP -0.299286922863212 1.69011727706147e-05 NA NA NA hsa-miR-500a-5p CCND2 1.72110365584658 3.0807246212659e-10 -2.42747067684236 2.06814828958882e-10 mirMAP -0.230284164405623 0.000679591942778451 NA NA NA hsa-miR-501-5p CCND2 1.93654809410041 1.3779381780759e-10 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP;miRNATAP -0.278516160908165 9.05358509837179e-06 NA NA NA hsa-miR-503-5p CCND2 3.66513190181895 6.60300917645278e-21 -2.42747067684236 2.06814828958882e-10 MirTarget -0.31264390956225 5.2815091282227e-11 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 2.11025227932763 6.94489556637146e-12 -2.42747067684236 2.06814828958882e-10 MirTarget -0.44540662591501 2.41152035101861e-14 NA NA NA hsa-miR-589-3p CCND2 2.51971841868825 2.39125940264107e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.360588568041429 3.76015378643146e-11 NA NA NA hsa-miR-590-3p CCND2 2.59289455139753 1.03200520972022e-21 -2.42747067684236 2.06814828958882e-10 miRanda;mirMAP -0.419988530136573 3.79848108645639e-10 NA NA NA hsa-miR-590-5p CCND2 3.18300989862077 2.06813568597893e-26 -2.42747067684236 2.06814828958882e-10 mirMAP -0.50562344923364 6.73026539304424e-18 NA NA NA hsa-miR-660-5p CCND2 1.82692095272076 1.92040083607196e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.361636929774302 8.5078492819456e-07 NA NA NA hsa-miR-7-1-3p CCND2 1.84950311431067 1.25300363397654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.518854235917429 5.32697612805784e-13 NA NA NA hsa-miR-708-3p CCND2 2.80907765282502 3.07460722669281e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.177604972093223 0.000316375213374722 NA NA NA hsa-miR-708-5p CCND2 3.38051631555486 5.12590198690777e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.19367896307831 2.62089031491477e-05 NA NA NA hsa-miR-877-5p CCND2 2.94916202082736 1.8151927276044e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.361363420346396 6.83899428438154e-13 NA NA NA hsa-miR-93-5p CCND2 3.03961860136032 1.11672209617395e-24 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.640135233296746 3.73391346199191e-30 NA NA NA hsa-miR-944 CCND2 2.91186649218281 1.31574753528144e-06 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.168575408637895 9.32931241492905e-08 NA NA NA hsa-miR-96-5p CCND2 4.89433085814374 1.92000659886961e-31 -2.42747067684236 2.06814828958882e-10 TargetScan;miRNATAP -0.382951897231727 7.25785958201884e-21 NA NA NA hsa-miR-27b-3p CCND3 0.196007704287769 0.295630157035388 0.142518749044219 0.397307080616203 miRNAWalker2_validate -0.133645004740845 0.00231237621077374 NA NA NA hsa-miR-139-5p CDH1 -1.52606598644743 1.20474151350665e-08 2.70562342616265 1.9661369341111e-09 PITA;miRanda -0.255426475960002 0.00180924947364428 NA NA NA hsa-miR-125a-3p CTGF 1.24490295132072 5.26925231010328e-06 -3.1646965721889 1.41660027051818e-12 PITA;miRanda -0.276496084105092 0.000607804236051295 NA NA NA hsa-miR-149-5p CTGF 2.94200492826326 4.93436498919036e-14 -3.1646965721889 1.41660027051818e-12 miRNATAP -0.380687798802941 1.46739217650299e-12 NA NA NA hsa-miR-16-2-3p CTGF 2.31623086727196 4.29838149388188e-20 -3.1646965721889 1.41660027051818e-12 MirTarget -0.742986683852501 3.48492935917027e-20 NA NA NA hsa-miR-18a-5p CTGF 3.78535678765353 3.72446596213886e-26 -3.1646965721889 1.41660027051818e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.521933840391543 1.25436249823488e-18 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 3.42309334186656 3.02671914353412e-28 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.625421227845991 7.9297931677912e-23 NA NA NA hsa-miR-19b-3p CTGF 2.49529833021187 1.57028265846699e-23 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.844188161775728 2.92266131554751e-26 NA NA NA hsa-miR-205-5p CTGF 4.1389800495524 2.05488295686453e-12 -3.1646965721889 1.41660027051818e-12 miRNAWalker2_validate;miRTarBase -0.333299257318783 1.37204454674649e-21 NA NA NA hsa-miR-26b-3p CTGF 2.18464160365372 2.11543189388328e-18 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.817366139085892 7.75317684169854e-24 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-26b-5p CTGF 0.885393662798425 3.2116297961629e-06 -3.1646965721889 1.41660027051818e-12 miRNATAP -0.68880035662657 2.17929453702755e-09 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-3065-5p CTGF 2.74629919868982 1.86846589298284e-08 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.321653443593315 2.49547811909434e-09 NA NA NA hsa-miR-330-3p CTGF 0.876747334239085 0.00073709016089703 -3.1646965721889 1.41660027051818e-12 MirTarget;PITA;miRNATAP -0.642502576701344 9.52940442652617e-15 NA NA NA hsa-miR-361-3p CTGF 1.07367425434318 1.73142774168958e-09 -3.1646965721889 1.41660027051818e-12 MirTarget;miRNATAP -0.462885035697563 0.000178540398596777 NA NA NA hsa-miR-375 CTGF 1.13910305294079 0.0512283522214186 -3.1646965721889 1.41660027051818e-12 miRNAWalker2_validate;miRanda -0.190568830223966 3.79777279474255e-07 NA NA NA hsa-miR-486-5p CTGF -0.194913133034028 0.607377798807705 -3.1646965721889 1.41660027051818e-12 miRanda -0.175746805388009 0.00272179996711368 NA NA NA hsa-miR-590-3p CTGF 2.59289455139753 1.03200520972022e-21 -3.1646965721889 1.41660027051818e-12 PITA;miRanda -0.688502163944404 4.25058637698374e-19 NA NA NA hsa-miR-7-1-3p CTGF 1.84950311431067 1.25300363397654e-13 -3.1646965721889 1.41660027051818e-12 MirTarget -0.653785189114178 8.24683254904366e-15 NA NA NA hsa-miR-140-5p CTNNA1 0.844753502512594 3.73722278438606e-05 -0.284632690198762 0.0151688080992981 miRanda -0.115600274788376 2.52848098385402e-05 NA NA NA hsa-miR-362-3p CTNNA1 2.0756816987665 3.89026064579331e-12 -0.284632690198762 0.0151688080992981 miRanda -0.10033225740032 9.85129772109938e-08 NA NA NA hsa-miR-146b-5p CTNNA3 1.75587235896724 1.15724631266659e-07 -1.93533463586447 0.000126947481038892 miRanda -0.297607516296167 4.44379635633636e-05 NA NA NA hsa-miR-21-3p CTNNA3 2.19296355304364 4.63665722759779e-15 -1.93533463586447 0.000126947481038892 MirTarget -0.616765035849569 1.01839014238908e-13 NA NA NA hsa-miR-34c-5p CTNNA3 2.07190852984647 7.35776320806257e-08 -1.93533463586447 0.000126947481038892 miRanda -0.301357712454327 6.25266974278528e-06 NA NA NA hsa-miR-590-3p CTNNA3 2.59289455139753 1.03200520972022e-21 -1.93533463586447 0.000126947481038892 miRanda -0.406045936996627 4.27344648768006e-06 NA NA NA hsa-miR-28-5p CTNNB1 0.230152919654905 0.0742909586754846 -0.220922161177096 0.11826020711692 miRanda -0.182072912507331 0.000829385072717343 NA NA NA hsa-let-7g-3p DLG2 3.26398061402445 3.96263126107645e-25 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.527444259956172 1.91960600303372e-12 NA NA NA hsa-miR-106a-5p DLG2 2.48882002962836 1.99757727374521e-12 -3.79723748090986 3.01897311382045e-14 mirMAP -0.365570686891079 7.18661376536419e-08 NA NA NA hsa-miR-1301-3p DLG2 2.54959518791507 5.26618591274892e-18 -3.79723748090986 3.01897311382045e-14 MirTarget -0.520142291477905 7.07894194081808e-11 NA NA NA hsa-miR-130a-3p DLG2 2.02021855058359 1.26427102520415e-11 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.575215284118756 5.43255736278508e-13 NA NA NA hsa-miR-130b-5p DLG2 2.9963110846538 1.98883029416455e-18 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.539621175634442 1.02711850574504e-14 NA NA NA hsa-miR-135b-5p DLG2 3.62510365056501 1.09148980810091e-10 -3.79723748090986 3.01897311382045e-14 MirTarget -0.287784486540329 1.80396540404523e-10 NA NA NA hsa-miR-140-5p DLG2 0.844753502512594 3.73722278438606e-05 -3.79723748090986 3.01897311382045e-14 PITA;miRanda;miRNATAP -0.462730698803255 0.000141436959262584 NA NA NA hsa-miR-142-3p DLG2 2.75247908790621 1.45636065474764e-12 -3.79723748090986 3.01897311382045e-14 miRanda -0.460210429604615 3.29035739843936e-14 NA NA NA hsa-miR-142-5p DLG2 1.17581605694506 0.0018174701991234 -3.79723748090986 3.01897311382045e-14 PITA;miRNATAP -0.393726515815152 1.26058669746268e-09 NA NA NA hsa-miR-146b-5p DLG2 1.75587235896724 1.15724631266659e-07 -3.79723748090986 3.01897311382045e-14 miRanda -0.512094444537363 1.67639192044861e-12 NA NA NA hsa-miR-148b-3p DLG2 1.97815018171325 6.07715327281595e-26 -3.79723748090986 3.01897311382045e-14 miRNAWalker2_validate;MirTarget -0.773379252484328 4.58172017604079e-10 NA NA NA hsa-miR-148b-5p DLG2 2.18024067300781 2.84770452413262e-14 -3.79723748090986 3.01897311382045e-14 mirMAP -0.514514702913599 5.25872325858821e-09 NA NA NA hsa-miR-15b-3p DLG2 2.33847028227712 4.29662877950836e-19 -3.79723748090986 3.01897311382045e-14 mirMAP -0.770581638156977 1.94195755070392e-18 NA NA NA hsa-miR-16-2-3p DLG2 2.31623086727196 4.29838149388188e-20 -3.79723748090986 3.01897311382045e-14 mirMAP -0.866257750051103 8.81228104038337e-22 NA NA NA hsa-miR-17-5p DLG2 3.2710598467455 9.93128340539455e-27 -3.79723748090986 3.01897311382045e-14 mirMAP -0.689686908482879 4.61918079161029e-21 NA NA NA hsa-miR-182-5p DLG2 3.53923166221814 5.07781258121574e-21 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.201897965137628 0.00137018119218625 NA NA NA hsa-miR-185-5p DLG2 2.34016206907488 1.17481626642022e-26 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.92531330003832 3.28170646033584e-19 NA NA NA hsa-miR-186-5p DLG2 1.47445398888668 3.0781726595413e-15 -3.79723748090986 3.01897311382045e-14 mirMAP -0.805587334734682 3.31944923848292e-10 NA NA NA hsa-miR-19a-3p DLG2 3.42309334186656 3.02671914353412e-28 -3.79723748090986 3.01897311382045e-14 mirMAP -0.642700456092183 5.25865048068755e-19 NA NA NA hsa-miR-19b-3p DLG2 2.49529833021187 1.57028265846699e-23 -3.79723748090986 3.01897311382045e-14 mirMAP -0.743931380193096 5.70325975850387e-16 NA NA NA hsa-miR-205-5p DLG2 4.1389800495524 2.05488295686453e-12 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.265272819369491 4.80530129437628e-11 NA NA NA hsa-miR-20a-5p DLG2 3.15577933619191 4.19753346442454e-25 -3.79723748090986 3.01897311382045e-14 mirMAP -0.615816792371799 1.51273003896725e-16 NA NA NA hsa-miR-20b-5p DLG2 2.07706563022469 1.10107236083433e-05 -3.79723748090986 3.01897311382045e-14 mirMAP -0.135655667130369 0.00948819474477139 NA NA NA hsa-miR-22-5p DLG2 1.88011544159252 1.63978222572222e-16 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.673148836069821 9.8978195670974e-11 NA NA NA hsa-miR-224-3p DLG2 1.87536386559317 6.15140969394846e-05 -3.79723748090986 3.01897311382045e-14 MirTarget -0.184005285137452 0.000874545567194236 NA NA NA hsa-miR-23a-3p DLG2 1.00493340843378 2.55313889288924e-08 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -1.15216999846595 3.83668623215805e-18 NA NA NA hsa-miR-24-3p DLG2 0.99989036772428 1.35595013650376e-07 -3.79723748090986 3.01897311382045e-14 MirTarget -1.11180378211837 1.14744245393122e-18 NA NA NA hsa-miR-25-3p DLG2 1.36472605225697 4.83790725935681e-11 -3.79723748090986 3.01897311382045e-14 mirMAP -0.576702511078296 9.14482302457377e-07 NA NA NA hsa-miR-27a-5p DLG2 0.0545598990316276 0.869091561924187 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.451141315096581 1.30755473158481e-09 NA NA NA hsa-miR-29a-3p DLG2 -0.35074463683376 0.161238718982428 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.298467625592758 0.00290957921288394 NA NA NA hsa-miR-29b-1-5p DLG2 1.55384379072167 4.76870585070176e-05 -3.79723748090986 3.01897311382045e-14 mirMAP -0.567608481475101 1.01652392874607e-17 NA NA NA hsa-miR-29b-3p DLG2 1.65828197923813 1.02676780888141e-09 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.450916535280807 4.70636869265722e-07 NA NA NA hsa-miR-3065-5p DLG2 2.74629919868982 1.86846589298284e-08 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.318151219584034 1.75868627814741e-07 NA NA NA hsa-miR-3127-5p DLG2 1.51846438737133 3.59571251672767e-07 -3.79723748090986 3.01897311382045e-14 mirMAP -0.409764463822705 5.69266218427157e-07 NA NA NA hsa-miR-32-3p DLG2 2.02436999565685 5.94091197945307e-09 -3.79723748090986 3.01897311382045e-14 mirMAP;miRNATAP -0.371600888124265 3.27241363136411e-06 NA NA NA hsa-miR-32-5p DLG2 2.34056473219422 6.24134585974322e-20 -3.79723748090986 3.01897311382045e-14 mirMAP -0.576615135482135 3.29239251436059e-10 NA NA NA hsa-miR-320b DLG2 1.55692969039548 1.41071034251915e-08 -3.79723748090986 3.01897311382045e-14 PITA;miRanda;mirMAP;miRNATAP -0.435710826809482 9.49870784818845e-07 NA NA NA hsa-miR-338-3p DLG2 0.453166438193782 0.144583389707558 -3.79723748090986 3.01897311382045e-14 PITA;mirMAP;miRNATAP -0.246086768803736 0.00223768970944328 NA NA NA hsa-miR-33a-3p DLG2 1.72765312072219 1.51784443453521e-07 -3.79723748090986 3.01897311382045e-14 MirTarget -0.233978944224334 0.00449747170600951 NA NA NA hsa-miR-33a-5p DLG2 3.79671563098419 1.15966309820345e-18 -3.79723748090986 3.01897311382045e-14 mirMAP -0.378997741040286 1.6604365558235e-10 NA NA NA hsa-miR-34c-3p DLG2 2.41359195938096 3.46966584087088e-10 -3.79723748090986 3.01897311382045e-14 MirTarget -0.408096223495123 2.83016303855834e-10 NA NA NA hsa-miR-3607-3p DLG2 2.68532138541128 5.66716351955047e-14 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.315795266013365 4.87398157587289e-06 NA NA NA hsa-miR-361-3p DLG2 1.07367425434318 1.73142774168958e-09 -3.79723748090986 3.01897311382045e-14 PITA;miRNATAP -0.761545391767077 2.9941447705722e-08 NA NA NA hsa-miR-3613-5p DLG2 2.64358387329263 1.0373753017245e-24 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.625853861846597 1.14893162935936e-11 NA NA NA hsa-miR-363-3p DLG2 1.50575300026701 0.00020976164678918 -3.79723748090986 3.01897311382045e-14 mirMAP -0.162000547283074 0.00806395081235773 NA NA NA hsa-miR-374b-3p DLG2 0.930487774873495 2.74420094310516e-05 -3.79723748090986 3.01897311382045e-14 mirMAP -0.404656859909547 0.000322774202413857 NA NA NA hsa-miR-421 DLG2 1.17791565395543 6.78526676976629e-06 -3.79723748090986 3.01897311382045e-14 miRanda -0.490094501562766 1.85056044379309e-07 NA NA NA hsa-miR-484 DLG2 1.81844463411787 1.82951571230938e-15 -3.79723748090986 3.01897311382045e-14 MirTarget;PITA -0.619568758914471 2.99910894951853e-09 NA NA NA hsa-miR-505-5p DLG2 1.89243395287645 9.82003586561819e-12 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.376025447612985 1.70376468669004e-05 NA NA NA hsa-miR-511-5p DLG2 1.04499312543772 0.00234126154508174 -3.79723748090986 3.01897311382045e-14 MirTarget -0.531868989104521 4.67954937488165e-14 NA NA NA hsa-miR-576-5p DLG2 2.20467023993664 3.4053475193793e-19 -3.79723748090986 3.01897311382045e-14 PITA;mirMAP -0.798565916073537 1.79281089910515e-17 NA NA NA hsa-miR-590-3p DLG2 2.59289455139753 1.03200520972022e-21 -3.79723748090986 3.01897311382045e-14 PITA;miRanda;mirMAP -0.696961457282413 1.5704900616442e-15 NA NA NA hsa-miR-590-5p DLG2 3.18300989862077 2.06813568597893e-26 -3.79723748090986 3.01897311382045e-14 PITA;miRanda -0.685941748733758 7.60722541972749e-19 NA NA NA hsa-miR-592 DLG2 1.51765968871077 0.000636335248013204 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.169448322838795 0.00291196839034129 NA NA NA hsa-miR-7-1-3p DLG2 1.84950311431067 1.25300363397654e-13 -3.79723748090986 3.01897311382045e-14 MirTarget -0.673878016779634 1.43367339830485e-12 NA NA NA hsa-miR-708-3p DLG2 2.80907765282502 3.07460722669281e-14 -3.79723748090986 3.01897311382045e-14 mirMAP -0.230533257569817 0.000408431651408213 NA NA NA hsa-miR-769-3p DLG2 2.19896922202687 5.69250370895053e-12 -3.79723748090986 3.01897311382045e-14 PITA;miRNATAP -0.418738763355435 7.15341532076342e-08 NA NA NA hsa-miR-769-5p DLG2 1.82023760596845 9.6815886564134e-14 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.393993211604957 7.04911036250871e-05 NA NA NA hsa-miR-877-5p DLG2 2.94916202082736 1.8151927276044e-13 -3.79723748090986 3.01897311382045e-14 MirTarget -0.401177336003199 2.29876245374781e-09 NA NA NA hsa-miR-92a-3p DLG2 2.06460102658973 1.44784291084757e-19 -3.79723748090986 3.01897311382045e-14 mirMAP -0.91893795585673 7.24513410087986e-20 NA NA NA hsa-miR-92b-3p DLG2 1.20409245530001 3.41055816361655e-06 -3.79723748090986 3.01897311382045e-14 mirMAP -0.473220346256659 5.87974316141609e-07 NA NA NA hsa-miR-93-3p DLG2 2.85383869771942 5.64481766902125e-23 -3.79723748090986 3.01897311382045e-14 MirTarget;miRNATAP -0.548183875580852 7.85687249235143e-12 NA NA NA hsa-miR-940 DLG2 3.21011374578759 2.7923171128495e-14 -3.79723748090986 3.01897311382045e-14 MirTarget;PITA;miRNATAP -0.306131262170108 7.77624775770955e-07 NA NA NA hsa-miR-944 DLG2 2.91186649218281 1.31574753528144e-06 -3.79723748090986 3.01897311382045e-14 PITA;mirMAP;miRNATAP -0.251529741913485 1.41209459098095e-09 NA NA NA hsa-miR-142-5p DLG3 1.17581605694506 0.0018174701991234 -0.0993745136535509 0.601300626415283 PITA;mirMAP -0.127422084044659 1.00634255130907e-07 NA NA NA hsa-miR-145-5p DLG3 -1.55259331973517 9.97889123247165e-07 -0.0993745136535509 0.601300626415283 mirMAP -0.122106735920961 1.71377224675204e-05 NA NA NA hsa-miR-299-5p DLG3 -0.274550626427337 0.386834031856446 -0.0993745136535509 0.601300626415283 miRNATAP -0.121697726187395 2.57836973876679e-05 NA NA NA hsa-miR-342-3p DLG3 1.49115144672245 1.43879249744621e-07 -0.0993745136535509 0.601300626415283 miRanda -0.113609726796698 0.000366237773566024 NA NA NA hsa-miR-149-5p DLG4 2.94200492826326 4.93436498919036e-14 -0.769004394162579 0.00353637842939569 miRNATAP -0.117128617778355 0.000211450267718595 NA NA NA hsa-miR-26b-5p DLG4 0.885393662798425 3.2116297961629e-06 -0.769004394162579 0.00353637842939569 miRNATAP -0.237986673567566 0.000393258098351453 NA NA NA hsa-miR-455-3p DLG4 3.06093594997644 3.54590649799868e-16 -0.769004394162579 0.00353637842939569 MirTarget;PITA;miRNATAP -0.133139168862237 4.56095131664117e-05 NA NA NA hsa-miR-30a-3p DVL3 -2.08290159592947 3.95783261640728e-14 0.412235294167264 0.000274823815979202 MirTarget -0.106440185561165 2.42872660854649e-08 NA NA NA hsa-miR-101-3p FBXW11 0.522819989585461 0.00375627731618038 -0.6053355793347 2.43759511622661e-07 MirTarget;miRNATAP -0.1068970532894 0.000831195472548073 NA NA NA hsa-miR-106b-5p FBXW11 2.46782146831112 1.36171495805632e-23 -0.6053355793347 2.43759511622661e-07 miRNATAP -0.133871111185436 6.31270412587771e-10 NA NA NA hsa-miR-148b-3p FBXW11 1.97815018171325 6.07715327281595e-26 -0.6053355793347 2.43759511622661e-07 miRNAWalker2_validate -0.14597497675447 3.43285563860754e-07 NA NA NA hsa-miR-16-5p FBXW11 1.75824877145857 1.68592440033108e-16 -0.6053355793347 2.43759511622661e-07 miRNAWalker2_validate -0.10499399238876 5.03647247156714e-05 NA NA NA hsa-miR-186-5p FBXW11 1.47445398888668 3.0781726595413e-15 -0.6053355793347 2.43759511622661e-07 mirMAP -0.166462193668095 1.66771830021087e-08 NA NA NA hsa-miR-19a-3p FBXW11 3.42309334186656 3.02671914353412e-28 -0.6053355793347 2.43759511622661e-07 MirTarget -0.108311755991211 1.45419218352444e-10 NA NA NA hsa-miR-19b-3p FBXW11 2.49529833021187 1.57028265846699e-23 -0.6053355793347 2.43759511622661e-07 MirTarget -0.127282346966739 2.81248393053129e-09 NA NA NA hsa-miR-301a-3p FBXW11 2.81024345929638 2.29784847962242e-17 -0.6053355793347 2.43759511622661e-07 MirTarget -0.102606306404108 2.81626252880213e-09 NA NA NA hsa-miR-330-3p FBXW11 0.876747334239085 0.00073709016089703 -0.6053355793347 2.43759511622661e-07 MirTarget;PITA;miRNATAP -0.10307956762463 2.31244947474721e-06 NA NA NA hsa-miR-374a-5p FBXW11 0.484615721953736 0.0042981729815149 -0.6053355793347 2.43759511622661e-07 mirMAP -0.135168340854082 7.00122336685201e-05 NA NA NA hsa-miR-450a-5p FBXW11 2.00113616793868 5.25910974095652e-13 -0.6053355793347 2.43759511622661e-07 miRNAWalker2_validate -0.106863968686943 1.69934387008649e-07 NA NA NA hsa-miR-454-3p FBXW11 2.47234127820054 1.12878018736016e-21 -0.6053355793347 2.43759511622661e-07 MirTarget -0.138327954771508 7.69148432838817e-11 NA NA NA hsa-miR-93-5p FBXW11 3.03961860136032 1.11672209617395e-24 -0.6053355793347 2.43759511622661e-07 miRNATAP -0.110444879718319 7.00982042662947e-10 NA NA NA hsa-miR-126-5p FGF1 0.895338176458417 2.33372756450713e-05 -0.0184880339301951 0.962515192576832 mirMAP -0.257052884478014 0.00418426830473386 NA NA NA hsa-miR-16-1-3p FGF1 2.56983217111073 3.02262181237943e-20 -0.0184880339301951 0.962515192576832 mirMAP -0.342294668806123 2.38586503825089e-07 NA NA NA hsa-miR-186-5p FGF1 1.47445398888668 3.0781726595413e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.591026951034186 1.46187678760819e-09 NA NA NA hsa-miR-18a-5p FGF1 3.78535678765353 3.72446596213886e-26 -0.0184880339301951 0.962515192576832 MirTarget -0.264847474948657 3.88610261864251e-07 NA NA NA hsa-miR-205-5p FGF1 4.1389800495524 2.05488295686453e-12 -0.0184880339301951 0.962515192576832 mirMAP -0.157775223845845 3.59117960754949e-07 NA NA NA hsa-miR-26b-3p FGF1 2.18464160365372 2.11543189388328e-18 -0.0184880339301951 0.962515192576832 MirTarget -0.423230901828247 4.44177310978311e-09 NA NA NA hsa-miR-320a FGF1 0.438165828017084 0.0390159073347133 -0.0184880339301951 0.962515192576832 miRanda -0.541959251848306 9.85803319868347e-10 NA NA NA hsa-miR-320b FGF1 1.55692969039548 1.41071034251915e-08 -0.0184880339301951 0.962515192576832 miRanda -0.407239237545482 1.30349593223329e-09 NA NA NA hsa-miR-330-5p FGF1 1.15100069700871 4.85551805046014e-07 -0.0184880339301951 0.962515192576832 miRanda;miRNATAP -0.439171157719847 7.15817077978881e-08 NA NA NA hsa-miR-361-5p FGF1 0.971859117235239 5.30236555707088e-09 -0.0184880339301951 0.962515192576832 miRanda -0.85349859964158 1.1628109767779e-14 NA NA NA hsa-miR-3913-5p FGF1 2.44353493655328 8.95279496632448e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.302608268342126 3.69363193887853e-07 NA NA NA hsa-miR-429 FGF1 4.48815175680773 2.44117492218206e-17 -0.0184880339301951 0.962515192576832 miRNATAP -0.267128349292686 9.69262295730924e-16 NA NA NA hsa-miR-484 FGF1 1.81844463411787 1.82951571230938e-15 -0.0184880339301951 0.962515192576832 MirTarget;PITA;miRNATAP -0.394116689453691 8.31708710335926e-07 NA NA NA hsa-miR-532-3p FGF1 1.96631878320218 4.53421954361695e-13 -0.0184880339301951 0.962515192576832 miRNATAP -0.440506181753794 4.21772989420151e-11 NA NA NA hsa-miR-550a-5p FGF1 2.11025227932763 6.94489556637146e-12 -0.0184880339301951 0.962515192576832 MirTarget -0.275012193152473 4.64050292544223e-06 NA NA NA hsa-miR-576-5p FGF1 2.20467023993664 3.4053475193793e-19 -0.0184880339301951 0.962515192576832 PITA;mirMAP -0.300128298067083 4.75057034180223e-05 NA NA NA hsa-miR-590-5p FGF1 3.18300989862077 2.06813568597893e-26 -0.0184880339301951 0.962515192576832 MirTarget;miRanda;miRNATAP -0.343013546630031 1.40984845888558e-08 NA NA NA hsa-miR-944 FGF1 2.91186649218281 1.31574753528144e-06 -0.0184880339301951 0.962515192576832 mirMAP -0.186547406811606 3.74734066850436e-09 NA NA NA hsa-miR-101-3p FRMD6 0.522819989585461 0.00375627731618038 -0.932146068496432 0.00182819765018773 miRNAWalker2_validate -0.359478833827609 8.61184102417595e-06 NA NA NA hsa-miR-106a-5p FRMD6 2.48882002962836 1.99757727374521e-12 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.263725976257686 1.5068180586475e-11 NA NA NA hsa-miR-106b-5p FRMD6 2.46782146831112 1.36171495805632e-23 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.387570988318694 1.24741798306772e-12 NA NA NA hsa-miR-130a-3p FRMD6 2.02021855058359 1.26427102520415e-11 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.136627064494234 0.00407865031832622 NA NA NA hsa-miR-130b-3p FRMD6 3.5350292994509 1.73934183852569e-27 -0.932146068496432 0.00182819765018773 MirTarget -0.243726865785527 3.159254231361e-09 NA NA NA hsa-miR-139-5p FRMD6 -1.52606598644743 1.20474151350665e-08 -0.932146068496432 0.00182819765018773 miRanda -0.143850405004531 0.00719668902183522 NA NA NA hsa-miR-140-3p FRMD6 0.0608890720479334 0.727716871248724 -0.932146068496432 0.00182819765018773 PITA -0.445121555410069 9.57190375908406e-08 NA NA NA hsa-miR-140-5p FRMD6 0.844753502512594 3.73722278438606e-05 -0.932146068496432 0.00182819765018773 miRanda -0.339567329119055 1.38173957537487e-06 NA NA NA hsa-miR-141-3p FRMD6 5.02396127982626 2.19224509139725e-24 -0.932146068496432 0.00182819765018773 MirTarget;TargetScan;miRNATAP -0.116995591435815 2.21065057353424e-05 NA NA NA hsa-miR-15b-3p FRMD6 2.33847028227712 4.29662877950836e-19 -0.932146068496432 0.00182819765018773 mirMAP -0.293866855075524 2.19607684047802e-08 NA NA NA hsa-miR-16-2-3p FRMD6 2.31623086727196 4.29838149388188e-20 -0.932146068496432 0.00182819765018773 mirMAP -0.272673396385445 5.93388417776337e-07 NA NA NA hsa-miR-17-5p FRMD6 3.2710598467455 9.93128340539455e-27 -0.932146068496432 0.00182819765018773 MirTarget;TargetScan;miRNATAP -0.256704156197704 5.20508527469857e-09 NA NA NA hsa-miR-183-5p FRMD6 4.19757025992371 4.79612296318304e-26 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.165229420492883 1.15069696112144e-06 NA NA NA hsa-miR-195-3p FRMD6 -0.658653229922836 0.0142127125129199 -0.932146068496432 0.00182819765018773 mirMAP -0.154645652093211 0.00502734822859917 NA NA NA hsa-miR-200a-3p FRMD6 4.59434485520731 6.38952518573476e-18 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.134179306352254 2.00184430837651e-07 NA NA NA hsa-miR-200b-3p FRMD6 3.78235093249346 3.18343003239465e-14 -0.932146068496432 0.00182819765018773 TargetScan -0.130065958119323 3.26038049911697e-06 NA NA NA hsa-miR-20a-5p FRMD6 3.15577933619191 4.19753346442454e-25 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.258361669453247 5.23598471597215e-09 NA NA NA hsa-miR-20b-5p FRMD6 2.07706563022469 1.10107236083433e-05 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.222707680930341 4.6403255833618e-14 NA NA NA hsa-miR-29b-2-5p FRMD6 0.910668640983475 0.00666655585493488 -0.932146068496432 0.00182819765018773 MirTarget -0.242411314694094 1.28917431442174e-08 NA NA NA hsa-miR-301a-3p FRMD6 2.81024345929638 2.29784847962242e-17 -0.932146068496432 0.00182819765018773 MirTarget -0.254243119655063 6.90885412442354e-09 NA NA NA hsa-miR-30b-5p FRMD6 0.800822374912712 0.000133601914525413 -0.932146068496432 0.00182819765018773 MirTarget -0.383198836057614 2.18450215283748e-08 NA NA NA hsa-miR-30c-5p FRMD6 0.778774633108 0.000285599212429136 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.406862072895815 1.03535772558644e-09 NA NA NA hsa-miR-30d-5p FRMD6 0.675423997639582 0.00270618816039773 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.381763315770569 2.01952608493805e-09 NA NA NA hsa-miR-30e-5p FRMD6 1.23904909539663 1.35561917122157e-09 -0.932146068496432 0.00182819765018773 MirTarget -0.524482913332978 1.51107136564017e-14 NA NA NA hsa-miR-335-3p FRMD6 3.08791651139852 5.31309869723517e-12 -0.932146068496432 0.00182819765018773 mirMAP -0.108888296847786 0.000542695528313818 NA NA NA hsa-miR-33a-3p FRMD6 1.72765312072219 1.51784443453521e-07 -0.932146068496432 0.00182819765018773 mirMAP -0.214582984133285 6.38419908181902e-06 NA NA NA hsa-miR-340-5p FRMD6 0.30282999308409 0.157744789519131 -0.932146068496432 0.00182819765018773 MirTarget -0.26100487645549 0.000126537870683219 NA NA NA hsa-miR-3613-5p FRMD6 2.64358387329263 1.0373753017245e-24 -0.932146068496432 0.00182819765018773 miRNATAP -0.152741728505656 0.00535343537563444 NA NA NA hsa-miR-362-3p FRMD6 2.0756816987665 3.89026064579331e-12 -0.932146068496432 0.00182819765018773 miRanda;miRNATAP -0.316422926414365 4.27162659578749e-11 NA NA NA hsa-miR-374a-5p FRMD6 0.484615721953736 0.0042981729815149 -0.932146068496432 0.00182819765018773 mirMAP -0.363771815215224 2.44543931321412e-05 NA NA NA hsa-miR-374b-5p FRMD6 0.0654362503857184 0.722673188879465 -0.932146068496432 0.00182819765018773 mirMAP -0.352444720656307 9.01571927048707e-06 NA NA NA hsa-miR-375 FRMD6 1.13910305294079 0.0512283522214186 -0.932146068496432 0.00182819765018773 miRanda -0.163398398364754 1.55624442629226e-11 NA NA NA hsa-miR-429 FRMD6 4.48815175680773 2.44117492218206e-17 -0.932146068496432 0.00182819765018773 miRanda;miRNATAP -0.123387280965507 2.18259759618339e-06 NA NA NA hsa-miR-454-3p FRMD6 2.47234127820054 1.12878018736016e-21 -0.932146068496432 0.00182819765018773 MirTarget -0.320009170308348 3.57578295590831e-09 NA NA NA hsa-miR-501-5p FRMD6 1.93654809410041 1.3779381780759e-10 -0.932146068496432 0.00182819765018773 MirTarget;PITA;miRNATAP -0.300136098806589 3.09153453175341e-10 NA NA NA hsa-miR-550a-3p FRMD6 1.78308792532884 2.47673569057582e-07 -0.932146068496432 0.00182819765018773 miRNATAP -0.121512190867103 0.00986840771572315 NA NA NA hsa-miR-590-3p FRMD6 2.59289455139753 1.03200520972022e-21 -0.932146068496432 0.00182819765018773 miRanda -0.2382574700917 4.85360997712578e-06 NA NA NA hsa-miR-671-5p FRMD6 2.97733652243246 1.21148452344738e-23 -0.932146068496432 0.00182819765018773 MirTarget -0.190451315772145 9.4015630641963e-05 NA NA NA hsa-miR-7-1-3p FRMD6 1.84950311431067 1.25300363397654e-13 -0.932146068496432 0.00182819765018773 MirTarget -0.336181976681053 1.68150180392733e-09 NA NA NA hsa-miR-93-5p FRMD6 3.03961860136032 1.11672209617395e-24 -0.932146068496432 0.00182819765018773 MirTarget;miRNATAP -0.34359817779145 2.07840985555766e-14 NA NA NA hsa-miR-148b-5p FZD1 2.18024067300781 2.84770452413262e-14 -0.425436558189808 0.0799738924745079 MirTarget -0.185337464920658 9.26075370601374e-06 NA NA NA hsa-miR-186-5p FZD1 1.47445398888668 3.0781726595413e-15 -0.425436558189808 0.0799738924745079 mirMAP -0.256651764559262 2.6511156970226e-05 NA NA NA hsa-miR-192-5p FZD1 2.69002528723195 1.22990188194432e-16 -0.425436558189808 0.0799738924745079 miRNAWalker2_validate -0.155057877498576 7.39037537532272e-06 NA NA NA hsa-miR-200a-5p FZD1 3.86316681673704 1.81076942093171e-15 -0.425436558189808 0.0799738924745079 MirTarget -0.113568422277534 8.68868038604123e-07 NA NA NA hsa-miR-200b-5p FZD1 2.54484902707822 1.59240467582976e-06 -0.425436558189808 0.0799738924745079 MirTarget -0.117574059809566 1.53611179067253e-06 NA NA NA hsa-miR-29b-3p FZD1 1.65828197923813 1.02676780888141e-09 -0.425436558189808 0.0799738924745079 mirMAP -0.262792829355677 3.08641120731195e-10 NA NA NA hsa-miR-29c-3p FZD1 -0.00968972577705429 0.97099586346872 -0.425436558189808 0.0799738924745079 mirMAP -0.235860731130814 7.14943079977686e-08 NA NA NA hsa-miR-590-3p FZD1 2.59289455139753 1.03200520972022e-21 -0.425436558189808 0.0799738924745079 miRanda -0.161949528189327 0.000129709540916742 NA NA NA hsa-miR-93-3p FZD1 2.85383869771942 5.64481766902125e-23 -0.425436558189808 0.0799738924745079 MirTarget -0.154987566584066 5.3611154116737e-05 NA NA NA hsa-miR-92b-3p FZD10 1.20409245530001 3.41055816361655e-06 -1.28150312911457 0.0222651851945126 miRNATAP -0.321084810294164 0.00202154343824695 NA NA NA hsa-let-7c-5p FZD3 -2.07847142524506 5.51224567263294e-09 -0.309421802986829 0.225620520315636 MirTarget -0.112394995313295 0.000923332007879197 NA NA NA hsa-let-7f-1-3p FZD3 1.55054488387679 7.31326775537952e-11 -0.309421802986829 0.225620520315636 MirTarget -0.184443397656298 0.000418481859781762 NA NA NA hsa-let-7i-5p FZD3 0.412877696970403 0.00622731051981756 -0.309421802986829 0.225620520315636 MirTarget;miRNATAP -0.399590260605759 1.3000716715047e-06 NA NA NA hsa-miR-140-5p FZD3 0.844753502512594 3.73722278438606e-05 -0.309421802986829 0.225620520315636 miRanda -0.188169794963344 0.00178065542348547 NA NA NA hsa-miR-142-3p FZD3 2.75247908790621 1.45636065474764e-12 -0.309421802986829 0.225620520315636 miRanda -0.169360517606185 2.61245265836168e-08 NA NA NA hsa-miR-145-5p FZD3 -1.55259331973517 9.97889123247165e-07 -0.309421802986829 0.225620520315636 mirMAP -0.114187387512836 0.00296030669990046 NA NA NA hsa-miR-146a-5p FZD3 1.19829319599115 0.00157081974524452 -0.309421802986829 0.225620520315636 MirTarget -0.158517509875284 7.77007948973314e-07 NA NA NA hsa-miR-146b-5p FZD3 1.75587235896724 1.15724631266659e-07 -0.309421802986829 0.225620520315636 MirTarget;miRanda -0.248619517368953 4.16178646137606e-12 NA NA NA hsa-miR-155-5p FZD3 1.20164021433135 0.00086170622431261 -0.309421802986829 0.225620520315636 mirMAP -0.223394374054016 1.99686402180728e-11 NA NA NA hsa-miR-16-2-3p FZD3 2.31623086727196 4.29838149388188e-20 -0.309421802986829 0.225620520315636 mirMAP -0.142741019197219 0.00229392409437174 NA NA NA hsa-miR-27a-3p FZD3 1.66542180327138 4.93775737894805e-13 -0.309421802986829 0.225620520315636 miRNATAP -0.19890982925031 0.000136253026426204 NA NA NA hsa-miR-29a-5p FZD3 1.46749674755271 3.34605004270294e-07 -0.309421802986829 0.225620520315636 mirMAP -0.227560485383059 2.97812930925699e-07 NA NA NA hsa-miR-30a-5p FZD3 -0.878357906436456 0.000509952992366057 -0.309421802986829 0.225620520315636 MirTarget;miRNATAP -0.187269850482729 0.000115755030201797 NA NA NA hsa-miR-338-3p FZD3 0.453166438193782 0.144583389707558 -0.309421802986829 0.225620520315636 PITA;miRanda -0.130140350228584 0.00105449606790809 NA NA NA hsa-miR-342-3p FZD3 1.49115144672245 1.43879249744621e-07 -0.309421802986829 0.225620520315636 miRanda -0.175491195046215 4.09956006364612e-05 NA NA NA hsa-miR-655-3p FZD3 0.485339318272148 0.137014658258732 -0.309421802986829 0.225620520315636 MirTarget -0.102336176080738 0.00792280380264869 NA NA NA hsa-let-7a-3p FZD4 1.42015538786275 7.03375209382654e-13 -0.82842258037894 0.00067769989049317 mirMAP -0.25978692105295 8.60947548901181e-06 NA NA NA hsa-let-7a-5p FZD4 0.618599506841644 2.76973453058748e-05 -0.82842258037894 0.00067769989049317 MirTarget;TargetScan;miRNATAP -0.253176019619405 0.00185266409499946 NA NA NA hsa-let-7b-3p FZD4 0.868207752019623 1.30460056774366e-05 -0.82842258037894 0.00067769989049317 mirMAP -0.288752028096756 9.73911194534638e-07 NA NA NA hsa-let-7b-5p FZD4 0.604314269683977 0.00140009936153214 -0.82842258037894 0.00067769989049317 MirTarget;miRNATAP -0.22284658021311 0.000398841305697788 NA NA NA hsa-let-7d-5p FZD4 1.33236798905207 1.1741085658466e-13 -0.82842258037894 0.00067769989049317 MirTarget;miRNATAP -0.265842261869076 3.75959518026377e-05 NA NA NA hsa-let-7f-1-3p FZD4 1.55054488387679 7.31326775537952e-11 -0.82842258037894 0.00067769989049317 mirMAP -0.283833517350996 1.05011620508551e-08 NA NA NA hsa-let-7g-3p FZD4 3.26398061402445 3.96263126107645e-25 -0.82842258037894 0.00067769989049317 MirTarget;miRNATAP -0.156205833669187 1.57695987305832e-05 NA NA NA hsa-miR-106b-5p FZD4 2.46782146831112 1.36171495805632e-23 -0.82842258037894 0.00067769989049317 miRNATAP -0.234613445833142 2.00902874110226e-07 NA NA NA hsa-miR-130b-3p FZD4 3.5350292994509 1.73934183852569e-27 -0.82842258037894 0.00067769989049317 mirMAP -0.13908667691121 4.12501037456859e-05 NA NA NA hsa-miR-141-3p FZD4 5.02396127982626 2.19224509139725e-24 -0.82842258037894 0.00067769989049317 TargetScan -0.113168852885507 4.32145832906429e-07 NA NA NA hsa-miR-15b-5p FZD4 1.57112623124278 9.14247846750597e-13 -0.82842258037894 0.00067769989049317 MirTarget -0.222207258760378 2.25967536549653e-05 NA NA NA hsa-miR-16-5p FZD4 1.75824877145857 1.68592440033108e-16 -0.82842258037894 0.00067769989049317 MirTarget -0.159732157502559 0.00302538129317839 NA NA NA hsa-miR-17-3p FZD4 2.2704817679209 1.1667437320211e-22 -0.82842258037894 0.00067769989049317 MirTarget -0.255826576295246 1.07111820305919e-07 NA NA NA hsa-miR-17-5p FZD4 3.2710598467455 9.93128340539455e-27 -0.82842258037894 0.00067769989049317 TargetScan -0.1860118666133 2.38183720623219e-07 NA NA NA hsa-miR-185-5p FZD4 2.34016206907488 1.17481626642022e-26 -0.82842258037894 0.00067769989049317 MirTarget -0.1624728760308 0.00145151073626332 NA NA NA hsa-miR-186-5p FZD4 1.47445398888668 3.0781726595413e-15 -0.82842258037894 0.00067769989049317 mirMAP -0.205145494132056 0.000907015467370243 NA NA NA hsa-miR-200c-3p FZD4 3.50132673580082 2.42716349086937e-15 -0.82842258037894 0.00067769989049317 mirMAP -0.112009526076228 1.27368925786649e-05 NA NA NA hsa-miR-20a-5p FZD4 3.15577933619191 4.19753346442454e-25 -0.82842258037894 0.00067769989049317 miRNATAP -0.166704290095965 4.54648957073464e-06 NA NA NA hsa-miR-21-5p FZD4 2.73773305747971 1.38864982139576e-43 -0.82842258037894 0.00067769989049317 mirMAP -0.239429729133893 8.97376444314049e-06 NA NA NA hsa-miR-24-3p FZD4 0.99989036772428 1.35595013650376e-07 -0.82842258037894 0.00067769989049317 miRNAWalker2_validate -0.359185041809163 4.66677691729471e-09 NA NA NA hsa-miR-25-3p FZD4 1.36472605225697 4.83790725935681e-11 -0.82842258037894 0.00067769989049317 mirMAP -0.19772322105664 0.000423841571889771 NA NA NA hsa-miR-27a-3p FZD4 1.66542180327138 4.93775737894805e-13 -0.82842258037894 0.00067769989049317 miRNATAP -0.292284213552613 3.45359392648561e-09 NA NA NA hsa-miR-27b-3p FZD4 0.196007704287769 0.295630157035388 -0.82842258037894 0.00067769989049317 miRNATAP -0.181363436048367 0.0046411443483725 NA NA NA hsa-miR-301a-3p FZD4 2.81024345929638 2.29784847962242e-17 -0.82842258037894 0.00067769989049317 mirMAP -0.117677900903377 0.00118038399178935 NA NA NA hsa-miR-3065-3p FZD4 2.16221780121195 9.65525739884541e-09 -0.82842258037894 0.00067769989049317 mirMAP -0.113524251684655 0.000224130806075724 NA NA NA hsa-miR-3065-5p FZD4 2.74629919868982 1.86846589298284e-08 -0.82842258037894 0.00067769989049317 mirMAP -0.119046399522189 4.20752397742188e-05 NA NA NA hsa-miR-32-3p FZD4 2.02436999565685 5.94091197945307e-09 -0.82842258037894 0.00067769989049317 mirMAP -0.121313188515894 0.00146602910261851 NA NA NA hsa-miR-32-5p FZD4 2.34056473219422 6.24134585974322e-20 -0.82842258037894 0.00067769989049317 mirMAP -0.203096878419163 3.87447920056755e-06 NA NA NA hsa-miR-324-3p FZD4 2.08739139768981 3.11885987067952e-13 -0.82842258037894 0.00067769989049317 miRNATAP -0.113264342841433 0.00491634431774974 NA NA NA hsa-miR-361-5p FZD4 0.971859117235239 5.30236555707088e-09 -0.82842258037894 0.00067769989049317 mirMAP -0.191172612241245 0.00713666078545409 NA NA NA hsa-miR-454-3p FZD4 2.47234127820054 1.12878018736016e-21 -0.82842258037894 0.00067769989049317 mirMAP -0.139970768625635 0.00181253009277159 NA NA NA hsa-miR-455-3p FZD4 3.06093594997644 3.54590649799868e-16 -0.82842258037894 0.00067769989049317 mirMAP -0.230319605456065 5.42542580292919e-15 NA NA NA hsa-miR-484 FZD4 1.81844463411787 1.82951571230938e-15 -0.82842258037894 0.00067769989049317 PITA -0.146355568993551 0.00363156555895962 NA NA NA hsa-miR-576-5p FZD4 2.20467023993664 3.4053475193793e-19 -0.82842258037894 0.00067769989049317 mirMAP -0.155015734273566 0.00077934632251741 NA NA NA hsa-miR-589-3p FZD4 2.51971841868825 2.39125940264107e-11 -0.82842258037894 0.00067769989049317 mirMAP -0.101476590178804 0.00364724192420982 NA NA NA hsa-miR-590-3p FZD4 2.59289455139753 1.03200520972022e-21 -0.82842258037894 0.00067769989049317 miRanda;mirMAP;miRNATAP -0.205499414009594 1.28884464268856e-06 NA NA NA hsa-miR-590-5p FZD4 3.18300989862077 2.06813568597893e-26 -0.82842258037894 0.00067769989049317 mirMAP -0.16093337799438 2.2971486034504e-05 NA NA NA hsa-miR-629-3p FZD4 2.36570947321815 1.33458201201618e-11 -0.82842258037894 0.00067769989049317 miRNATAP -0.173241875105555 3.00908592587117e-06 NA NA NA hsa-miR-7-1-3p FZD4 1.84950311431067 1.25300363397654e-13 -0.82842258037894 0.00067769989049317 mirMAP -0.289387180518199 1.81200956234101e-10 NA NA NA hsa-miR-708-5p FZD4 3.38051631555486 5.12590198690777e-18 -0.82842258037894 0.00067769989049317 miRNATAP -0.126330673307189 1.20305402790233e-05 NA NA NA hsa-miR-92a-3p FZD4 2.06460102658973 1.44784291084757e-19 -0.82842258037894 0.00067769989049317 mirMAP -0.276111924541506 2.02594943913648e-08 NA NA NA hsa-miR-92b-3p FZD4 1.20409245530001 3.41055816361655e-06 -0.82842258037894 0.00067769989049317 mirMAP -0.174194495695691 0.000116092372079185 NA NA NA hsa-miR-100-5p FZD5 -1.48442967087177 1.5610956769298e-05 0.915137361219814 0.000223509460129262 MirTarget;miRNATAP -0.138861957208489 6.08025549765444e-05 NA NA NA hsa-miR-139-5p FZD6 -1.52606598644743 1.20474151350665e-08 0.392854306882718 0.0923152139379722 miRanda -0.185158723711081 7.18808904187687e-06 NA NA NA hsa-miR-199a-5p FZD6 0.592984035153911 0.0674836634175293 0.392854306882718 0.0923152139379722 MirTarget;miRanda;miRNATAP -0.124790773147726 0.000323934870815636 25772759 FZD6 expression is negatively regulated by miR 199a 5p in human colorectal cancer; These results suggest that overexpression of FZD6 mediated by reduced expression of miR-199a-5p may play an important role in the development of CRC colorectal cancer hsa-miR-106b-5p FZD7 2.46782146831112 1.36171495805632e-23 -2.07792245991139 2.14296526511864e-14 miRNATAP -0.339574506280624 3.43686586684063e-11 NA NA NA hsa-miR-130b-5p FZD7 2.9963110846538 1.98883029416455e-18 -2.07792245991139 2.14296526511864e-14 mirMAP -0.206728540438605 8.73355100311931e-08 NA NA NA hsa-miR-142-3p FZD7 2.75247908790621 1.45636065474764e-12 -2.07792245991139 2.14296526511864e-14 miRanda -0.152811454409089 5.81592039338386e-06 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-186-5p FZD7 1.47445398888668 3.0781726595413e-15 -2.07792245991139 2.14296526511864e-14 mirMAP -0.421660397889243 1.57443547405505e-09 NA NA NA hsa-miR-192-5p FZD7 2.69002528723195 1.22990188194432e-16 -2.07792245991139 2.14296526511864e-14 miRNAWalker2_validate -0.260277559911997 4.18887516142845e-11 NA NA NA hsa-miR-20a-5p FZD7 3.15577933619191 4.19753346442454e-25 -2.07792245991139 2.14296526511864e-14 miRNATAP -0.279471256463213 1.0295927958098e-11 NA NA NA hsa-miR-215-5p FZD7 2.30755467422978 2.38476032118039e-06 -2.07792245991139 2.14296526511864e-14 miRNAWalker2_validate -0.147125197323382 1.3786520227744e-07 NA NA NA hsa-miR-27a-3p FZD7 1.66542180327138 4.93775737894805e-13 -2.07792245991139 2.14296526511864e-14 MirTarget;miRNATAP -0.277575918923312 1.16882224241177e-06 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-3065-5p FZD7 2.74629919868982 1.86846589298284e-08 -2.07792245991139 2.14296526511864e-14 MirTarget;miRNATAP -0.116253203875887 0.000504667102805114 NA NA NA hsa-miR-330-3p FZD7 0.876747334239085 0.00073709016089703 -2.07792245991139 2.14296526511864e-14 mirMAP -0.208278834363313 6.1985483100947e-05 NA NA NA hsa-miR-335-3p FZD7 3.08791651139852 5.31309869723517e-12 -2.07792245991139 2.14296526511864e-14 mirMAP -0.110301729451537 0.000176139270239384 NA NA NA hsa-miR-33a-3p FZD7 1.72765312072219 1.51784443453521e-07 -2.07792245991139 2.14296526511864e-14 mirMAP;miRNATAP -0.190495098959605 1.87779599885811e-05 NA NA NA hsa-miR-429 FZD7 4.48815175680773 2.44117492218206e-17 -2.07792245991139 2.14296526511864e-14 miRanda;miRNATAP -0.141505473835618 4.98870806283658e-09 NA NA NA hsa-miR-532-5p FZD7 1.55697650978597 1.57884735535196e-11 -2.07792245991139 2.14296526511864e-14 PITA;miRNATAP -0.263789010664099 4.11126202273311e-06 NA NA NA hsa-miR-590-3p FZD7 2.59289455139753 1.03200520972022e-21 -2.07792245991139 2.14296526511864e-14 miRanda -0.352411608450585 1.67919803776145e-13 NA NA NA hsa-miR-940 FZD7 3.21011374578759 2.7923171128495e-14 -2.07792245991139 2.14296526511864e-14 miRNAWalker2_validate -0.171852955105736 3.30424707745803e-07 NA NA NA hsa-miR-324-5p FZD8 2.95683728155095 1.32960514360912e-20 -0.823815646444258 0.00951023084929651 miRanda -0.279779712433669 7.35608925341817e-10 NA NA NA hsa-miR-429 FZD8 4.48815175680773 2.44117492218206e-17 -0.823815646444258 0.00951023084929651 miRanda -0.179347702117017 5.02703658451684e-11 NA NA NA hsa-miR-491-5p FZD8 0.615770352820862 0.0418295628761654 -0.823815646444258 0.00951023084929651 miRanda -0.185509761219535 0.000672381095466849 NA NA NA hsa-miR-590-3p FZD8 2.59289455139753 1.03200520972022e-21 -0.823815646444258 0.00951023084929651 miRanda -0.299591132423302 5.09896542046123e-08 NA NA NA hsa-miR-7-1-3p FZD8 1.84950311431067 1.25300363397654e-13 -0.823815646444258 0.00951023084929651 MirTarget -0.247871957087296 3.43262854275173e-05 NA NA NA hsa-miR-99b-5p FZD8 0.814286288944185 0.000299800699512742 -0.823815646444258 0.00951023084929651 MirTarget -0.211256090995937 0.00201196100333719 NA NA NA hsa-miR-129-5p GDF5 -0.524170159980738 0.222582956006346 -0.0453868434412796 0.928870355717812 miRanda -0.165047272235026 0.00463078852062911 NA NA NA hsa-miR-590-5p GDF5 3.18300989862077 2.06813568597893e-26 -0.0453868434412796 0.928870355717812 miRanda -0.250751177480169 0.00154618702172687 NA NA NA hsa-let-7d-5p GDF6 1.33236798905207 1.1741085658466e-13 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.827037779500331 7.94176953140371e-10 NA NA NA hsa-let-7f-5p GDF6 0.495648727272215 0.00355972741198794 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.496103897849871 0.000851574675341571 NA NA NA hsa-let-7g-5p GDF6 1.20061455355116 1.50237505511483e-12 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.965042822277671 1.23975458351993e-11 NA NA NA hsa-miR-125a-3p GDF6 1.24490295132072 5.26925231010328e-06 -1.13505992050111 0.0279057480958108 miRanda -0.237939076878051 0.0089491759493519 NA NA NA hsa-miR-141-3p GDF6 5.02396127982626 2.19224509139725e-24 -1.13505992050111 0.0279057480958108 TargetScan -0.341173884857515 2.2217799210351e-13 NA NA NA hsa-miR-141-5p GDF6 3.81419396518882 3.21977359736126e-18 -1.13505992050111 0.0279057480958108 mirMAP -0.359939094243448 1.66528449741244e-11 NA NA NA hsa-miR-193a-3p GDF6 1.60460546928078 2.86169793322984e-07 -1.13505992050111 0.0279057480958108 miRanda -0.306692810780015 9.74048617805209e-05 NA NA NA hsa-miR-200b-3p GDF6 3.78235093249346 3.18343003239465e-14 -1.13505992050111 0.0279057480958108 TargetScan -0.293866844040767 7.1280401489341e-10 NA NA NA hsa-miR-205-5p GDF6 4.1389800495524 2.05488295686453e-12 -1.13505992050111 0.0279057480958108 miRNATAP -0.171161056724495 3.00345054906495e-05 NA NA NA hsa-miR-23a-5p GDF6 1.46491071577368 0.000241866585858992 -1.13505992050111 0.0279057480958108 miRNATAP -0.2179816387183 0.000991679833494399 NA NA NA hsa-miR-30d-3p GDF6 0.977747550180601 4.3048212205381e-05 -1.13505992050111 0.0279057480958108 miRNATAP -0.567834803094083 3.71753630877376e-08 NA NA NA hsa-miR-324-5p GDF6 2.95683728155095 1.32960514360912e-20 -1.13505992050111 0.0279057480958108 miRanda -0.527333487445525 5.79720902220909e-13 NA NA NA hsa-miR-330-3p GDF6 0.876747334239085 0.00073709016089703 -1.13505992050111 0.0279057480958108 PITA;miRNATAP -0.434086776266481 5.5008849526711e-06 NA NA NA hsa-miR-339-5p GDF6 2.68710938429893 3.03134080808154e-16 -1.13505992050111 0.0279057480958108 miRanda -0.486069529133264 1.25211647052908e-11 NA NA NA hsa-miR-3607-3p GDF6 2.68532138541128 5.66716351955047e-14 -1.13505992050111 0.0279057480958108 MirTarget;miRNATAP -0.293210070673825 2.3457967080501e-05 NA NA NA hsa-miR-429 GDF6 4.48815175680773 2.44117492218206e-17 -1.13505992050111 0.0279057480958108 PITA;miRanda;miRNATAP -0.282911581669513 1.86916527400181e-10 NA NA NA hsa-miR-532-3p GDF6 1.96631878320218 4.53421954361695e-13 -1.13505992050111 0.0279057480958108 PITA;miRNATAP -0.731174627698996 2.84429193683468e-17 NA NA NA hsa-miR-589-3p GDF6 2.51971841868825 2.39125940264107e-11 -1.13505992050111 0.0279057480958108 MirTarget -0.450064572426505 5.154786454781e-10 NA NA NA hsa-miR-590-3p GDF6 2.59289455139753 1.03200520972022e-21 -1.13505992050111 0.0279057480958108 miRanda;mirMAP -0.553072945689467 4.80578078950766e-10 NA NA NA hsa-miR-944 GDF6 2.91186649218281 1.31574753528144e-06 -1.13505992050111 0.0279057480958108 PITA;mirMAP;miRNATAP -0.174156006437381 3.51134149955132e-05 NA NA NA hsa-miR-98-5p GDF6 1.11154309866014 1.24143909012085e-08 -1.13505992050111 0.0279057480958108 MirTarget -0.786793037725904 3.05451373036232e-10 NA NA NA hsa-miR-10b-3p GLI2 0.77597971642517 0.00264877454133753 -2.28902662613598 1.9678941791174e-06 MirTarget -0.729879437066698 1.23837244852469e-16 NA NA NA hsa-miR-141-3p GLI2 5.02396127982626 2.19224509139725e-24 -2.28902662613598 1.9678941791174e-06 MirTarget -0.490600186796826 7.08521741863515e-32 NA NA NA hsa-miR-15b-3p GLI2 2.33847028227712 4.29662877950836e-19 -2.28902662613598 1.9678941791174e-06 mirMAP -0.6987448225055 4.85578547629491e-17 NA NA NA hsa-miR-182-5p GLI2 3.53923166221814 5.07781258121574e-21 -2.28902662613598 1.9678941791174e-06 MirTarget -0.513578930610023 2.39073152531938e-19 NA NA NA hsa-miR-200a-3p GLI2 4.59434485520731 6.38952518573476e-18 -2.28902662613598 1.9678941791174e-06 MirTarget -0.401973371204554 1.28616793587481e-23 NA NA NA hsa-miR-26b-5p GLI2 0.885393662798425 3.2116297961629e-06 -2.28902662613598 1.9678941791174e-06 miRNAWalker2_validate -0.784441765005035 1.10695091989397e-10 NA NA NA hsa-miR-30b-5p GLI2 0.800822374912712 0.000133601914525413 -2.28902662613598 1.9678941791174e-06 MirTarget -0.62621218954716 1.70746558997114e-08 NA NA NA hsa-miR-30c-5p GLI2 0.778774633108 0.000285599212429136 -2.28902662613598 1.9678941791174e-06 MirTarget -0.856604990065934 8.32251736898407e-16 NA NA NA hsa-miR-30d-5p GLI2 0.675423997639582 0.00270618816039773 -2.28902662613598 1.9678941791174e-06 MirTarget -0.953725499044669 1.54770046111866e-21 NA NA NA hsa-miR-30e-5p GLI2 1.23904909539663 1.35561917122157e-09 -2.28902662613598 1.9678941791174e-06 MirTarget -1.23545712684017 2.00596505707796e-31 NA NA NA hsa-miR-31-5p GLI2 3.59165123035072 2.27423212057482e-07 -2.28902662613598 1.9678941791174e-06 miRNAWalker2_validate -0.157687585714505 7.45971280308318e-06 NA NA NA hsa-miR-320a GLI2 0.438165828017084 0.0390159073347133 -2.28902662613598 1.9678941791174e-06 miRanda -0.68838124777279 3.65928630818168e-10 NA NA NA hsa-miR-320b GLI2 1.55692969039548 1.41071034251915e-08 -2.28902662613598 1.9678941791174e-06 miRanda -0.557805534209779 1.63141577742983e-11 NA NA NA hsa-miR-330-5p GLI2 1.15100069700871 4.85551805046014e-07 -2.28902662613598 1.9678941791174e-06 MirTarget -0.64888247742458 9.9464726157787e-11 NA NA NA hsa-miR-33a-3p GLI2 1.72765312072219 1.51784443453521e-07 -2.28902662613598 1.9678941791174e-06 MirTarget -0.60350285849147 9.90008060371162e-16 NA NA NA hsa-miR-3607-3p GLI2 2.68532138541128 5.66716351955047e-14 -2.28902662613598 1.9678941791174e-06 miRNATAP -0.5008212484258 3.56919193690466e-15 NA NA NA hsa-miR-491-5p GLI2 0.615770352820862 0.0418295628761654 -2.28902662613598 1.9678941791174e-06 miRanda -0.330335575360409 7.2395523142029e-05 NA NA NA hsa-miR-501-3p GLI2 1.83132758513743 1.10971547702065e-10 -2.28902662613598 1.9678941791174e-06 MirTarget;miRNATAP -0.467924658800601 5.21322089718262e-09 NA NA NA hsa-miR-502-3p GLI2 1.50560877085049 1.2647489756373e-11 -2.28902662613598 1.9678941791174e-06 MirTarget;miRNATAP -0.451759137820458 1.2536513518942e-05 NA NA NA hsa-miR-664a-3p GLI2 0.634721925861133 0.00520070178640421 -2.28902662613598 1.9678941791174e-06 MirTarget -0.699690624508934 6.21131953904544e-12 NA NA NA hsa-miR-139-5p GSK3B -1.52606598644743 1.20474151350665e-08 0.406268283461383 0.000508906658360755 mirMAP -0.100160771461377 1.20519675407331e-06 NA NA NA hsa-miR-100-5p ID1 -1.48442967087177 1.5610956769298e-05 -0.110499119997154 0.797833760755636 miRNAWalker2_validate -0.385725210844168 5.78825527456675e-11 NA NA NA hsa-miR-195-3p ID1 -0.658653229922836 0.0142127125129199 -0.110499119997154 0.797833760755636 MirTarget;miRNATAP -0.224788053565875 0.00448313807537416 NA NA NA hsa-miR-29a-3p ID1 -0.35074463683376 0.161238718982428 -0.110499119997154 0.797833760755636 MirTarget -0.299094282117428 0.000338656572077568 NA NA NA hsa-miR-338-5p ID1 -0.577691606146419 0.0472212680542825 -0.110499119997154 0.797833760755636 MirTarget;PITA;miRNATAP -0.27813670748364 0.00011318808154234 NA NA NA hsa-let-7a-3p ID2 1.42015538786275 7.03375209382654e-13 -1.54654357209616 1.27444108702092e-06 miRNATAP -0.358646681831114 3.17261659036183e-06 NA NA NA hsa-let-7b-3p ID2 0.868207752019623 1.30460056774366e-05 -1.54654357209616 1.27444108702092e-06 miRNATAP -0.283914204742337 0.000289181687117768 NA NA NA hsa-miR-19a-3p ID2 3.42309334186656 3.02671914353412e-28 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.16516373144464 0.000436575283437063 NA NA NA hsa-miR-19b-3p ID2 2.49529833021187 1.57028265846699e-23 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.157910549016721 0.0079766133260792 NA NA NA hsa-miR-27a-3p ID2 1.66542180327138 4.93775737894805e-13 -1.54654357209616 1.27444108702092e-06 MirTarget;miRNATAP -0.415869746928321 1.64119825970062e-10 NA NA NA hsa-miR-338-3p ID2 0.453166438193782 0.144583389707558 -1.54654357209616 1.27444108702092e-06 miRanda -0.150326580770318 0.00285978135046781 NA NA NA hsa-miR-455-3p ID2 3.06093594997644 3.54590649799868e-16 -1.54654357209616 1.27444108702092e-06 MirTarget;PITA;miRNATAP -0.212973966922076 7.67722071909368e-08 NA NA NA hsa-miR-590-3p ID2 2.59289455139753 1.03200520972022e-21 -1.54654357209616 1.27444108702092e-06 miRanda -0.168489146813562 0.00286466301670518 NA NA NA hsa-miR-9-5p ID2 1.02304182473283 0.042901377604859 -1.54654357209616 1.27444108702092e-06 miRNAWalker2_validate;miRTarBase -0.114949551075085 0.000184259502532564 NA NA NA hsa-miR-125a-5p ITGB2 0.599529391575274 0.0102300147180307 -0.47094341720667 0.297854460695158 miRanda -0.510158066498813 3.90715484642447e-08 NA NA NA hsa-miR-335-5p ITGB2 1.77247705492746 2.22457658872091e-06 -0.47094341720667 0.297854460695158 miRNAWalker2_validate -0.239574526796931 2.97527067255492e-05 NA NA NA hsa-miR-429 ITGB2 4.48815175680773 2.44117492218206e-17 -0.47094341720667 0.297854460695158 miRanda -0.411734369505326 9.38404803396902e-29 NA NA NA hsa-miR-103a-2-5p LATS1 2.47599305985086 7.933028987326e-11 -0.728264634976516 0.00251777297344159 MirTarget -0.159677435803582 2.15934704656081e-06 NA NA NA hsa-miR-103a-3p LATS1 1.44083190496858 1.53799939616416e-13 -0.728264634976516 0.00251777297344159 miRNAWalker2_validate;MirTarget -0.152438604727689 0.00955458257840729 NA NA NA hsa-miR-15a-5p LATS1 2.34669284378787 1.69544424500258e-23 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.21605844363242 4.24104083225893e-06 NA NA NA hsa-miR-16-2-3p LATS1 2.31623086727196 4.29838149388188e-20 -0.728264634976516 0.00251777297344159 mirMAP -0.120088794836129 0.0068794745810913 NA NA NA hsa-miR-181a-2-3p LATS1 2.19062681262366 3.81790102612782e-13 -0.728264634976516 0.00251777297344159 MirTarget -0.1296837139578 0.000571196798970507 NA NA NA hsa-miR-181a-5p LATS1 2.29556023480783 1.8138457900616e-21 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.226306793227026 8.10370433992916e-07 NA NA NA hsa-miR-181b-5p LATS1 2.49307679431293 3.92829250217627e-20 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.154197113166953 0.000176184316961279 NA NA NA hsa-miR-181c-5p LATS1 1.58587920618301 1.57506918816933e-10 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.203158260792258 1.0310591721741e-05 NA NA NA hsa-miR-181d-5p LATS1 1.52204912185579 9.2693319057748e-08 -0.728264634976516 0.00251777297344159 MirTarget -0.125240269304981 0.00200915481257029 NA NA NA hsa-miR-193a-3p LATS1 1.60460546928078 2.86169793322984e-07 -0.728264634976516 0.00251777297344159 miRanda -0.112546115005862 0.00230328369177318 NA NA NA hsa-miR-194-5p LATS1 1.8992998339217 3.76507853301977e-10 -0.728264634976516 0.00251777297344159 miRNATAP -0.108848605291542 0.00400268569989429 NA NA NA hsa-miR-19b-1-5p LATS1 2.57951428759379 4.31576118703427e-20 -0.728264634976516 0.00251777297344159 MirTarget -0.118570305678162 0.00374857968966866 NA NA NA hsa-miR-21-5p LATS1 2.73773305747971 1.38864982139576e-43 -0.728264634976516 0.00251777297344159 miRNAWalker2_validate -0.238133309919206 7.69461047041298e-06 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-25-3p LATS1 1.36472605225697 4.83790725935681e-11 -0.728264634976516 0.00251777297344159 miRNATAP -0.162133138584792 0.00349580943726463 NA NA NA hsa-miR-29a-5p LATS1 1.46749674755271 3.34605004270294e-07 -0.728264634976516 0.00251777297344159 MirTarget -0.174592660081215 3.71221984627273e-05 NA NA NA hsa-miR-30d-3p LATS1 0.977747550180601 4.3048212205381e-05 -0.728264634976516 0.00251777297344159 mirMAP -0.160221744545766 0.00102477436386411 NA NA NA hsa-miR-32-5p LATS1 2.34056473219422 6.24134585974322e-20 -0.728264634976516 0.00251777297344159 miRNATAP -0.14631410994458 0.000810340119615875 NA NA NA hsa-miR-320a LATS1 0.438165828017084 0.0390159073347133 -0.728264634976516 0.00251777297344159 miRanda;miRNATAP -0.153029850507115 0.00586562412569888 NA NA NA hsa-miR-3607-3p LATS1 2.68532138541128 5.66716351955047e-14 -0.728264634976516 0.00251777297344159 MirTarget -0.115506872781635 0.000381831927749546 NA NA NA hsa-miR-497-5p LATS1 0.0257087130056286 0.918145413833358 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.155622272383027 0.000925173910257878 NA NA NA hsa-miR-590-3p LATS1 2.59289455139753 1.03200520972022e-21 -0.728264634976516 0.00251777297344159 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.120951700888804 0.0042362669164196 NA NA NA hsa-miR-590-5p LATS1 3.18300989862077 2.06813568597893e-26 -0.728264634976516 0.00251777297344159 miRanda;miRNATAP -0.148269587763011 7.98398714476422e-05 NA NA NA hsa-miR-103a-3p LATS2 1.44083190496858 1.53799939616416e-13 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.545078088921721 1.01249305570253e-24 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-107 LATS2 1.30977326593435 1.30372468603965e-11 -1.50195936145544 2.88260453000506e-11 PITA;miRanda;miRNATAP -0.416521294602422 5.32722251910862e-14 NA NA NA hsa-miR-125a-5p LATS2 0.599529391575274 0.0102300147180307 -1.50195936145544 2.88260453000506e-11 miRanda -0.21781018086606 5.01985416818712e-06 NA NA NA hsa-miR-130b-5p LATS2 2.9963110846538 1.98883029416455e-18 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.302045570964604 4.77360340232615e-23 NA NA NA hsa-miR-15a-5p LATS2 2.34669284378787 1.69544424500258e-23 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.374491797147539 7.9868614793595e-18 NA NA NA hsa-miR-15b-5p LATS2 1.57112623124278 9.14247846750597e-13 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.433674019729412 9.15682310083165e-20 NA NA NA hsa-miR-16-5p LATS2 1.75824877145857 1.68592440033108e-16 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.386303125464207 4.6978239258313e-15 NA NA NA hsa-miR-188-5p LATS2 2.52825126596644 6.78099435999778e-14 -1.50195936145544 2.88260453000506e-11 PITA -0.160210846022289 2.42310582682938e-06 NA NA NA hsa-miR-200b-3p LATS2 3.78235093249346 3.18343003239465e-14 -1.50195936145544 2.88260453000506e-11 TargetScan -0.239804941398232 6.61387628314149e-33 NA NA NA hsa-miR-200c-3p LATS2 3.50132673580082 2.42716349086937e-15 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.25601848144934 2.48894504027114e-29 NA NA NA hsa-miR-25-3p LATS2 1.36472605225697 4.83790725935681e-11 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.454631951504411 4.26702489689902e-19 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-30c-5p LATS2 0.778774633108 0.000285599212429136 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.406395457209951 8.42251456625388e-16 NA NA NA hsa-miR-30d-5p LATS2 0.675423997639582 0.00270618816039773 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.39436956563667 2.52948655768174e-16 NA NA NA hsa-miR-32-3p LATS2 2.02436999565685 5.94091197945307e-09 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.252828079392184 6.10666994340033e-13 NA NA NA hsa-miR-32-5p LATS2 2.34056473219422 6.24134585974322e-20 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.328851943356694 4.23747028480072e-16 NA NA NA hsa-miR-33a-3p LATS2 1.72765312072219 1.51784443453521e-07 -1.50195936145544 2.88260453000506e-11 mirMAP -0.263137980113084 2.27886870181046e-13 NA NA NA hsa-miR-342-3p LATS2 1.49115144672245 1.43879249744621e-07 -1.50195936145544 2.88260453000506e-11 PITA;miRanda -0.128936577647804 0.00092028917287548 NA NA NA hsa-miR-361-5p LATS2 0.971859117235239 5.30236555707088e-09 -1.50195936145544 2.88260453000506e-11 miRanda -0.602049312013823 4.88606279740226e-21 NA NA NA hsa-miR-362-3p LATS2 2.0756816987665 3.89026064579331e-12 -1.50195936145544 2.88260453000506e-11 PITA;miRanda -0.167202266945711 8.02098864297333e-06 NA NA NA hsa-miR-374a-5p LATS2 0.484615721953736 0.0042981729815149 -1.50195936145544 2.88260453000506e-11 mirMAP -0.274599596911397 3.52932415706869e-05 NA NA NA hsa-miR-429 LATS2 4.48815175680773 2.44117492218206e-17 -1.50195936145544 2.88260453000506e-11 PITA;miRanda;miRNATAP -0.223274644955359 8.82062181506915e-33 NA NA NA hsa-miR-590-3p LATS2 2.59289455139753 1.03200520972022e-21 -1.50195936145544 2.88260453000506e-11 PITA;miRanda -0.304394683115022 8.31248193031269e-15 NA NA NA hsa-miR-92a-3p LATS2 2.06460102658973 1.44784291084757e-19 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.46068812600106 3.77311823852666e-25 NA NA NA hsa-miR-93-5p LATS2 3.03961860136032 1.11672209617395e-24 -1.50195936145544 2.88260453000506e-11 miRNAWalker2_validate -0.422183319683058 1.37660464449381e-38 NA NA NA hsa-miR-96-5p LATS2 4.89433085814374 1.92000659886961e-31 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.269868454196079 2.91863438557395e-30 NA NA NA hsa-miR-26b-5p LEF1 0.885393662798425 3.2116297961629e-06 0.331269268157301 0.289787632933989 miRNATAP -0.274638576592703 0.000542709321878361 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-320b LEF1 1.55692969039548 1.41071034251915e-08 0.331269268157301 0.289787632933989 miRanda;mirMAP -0.1663193228511 0.00218419474879364 NA NA NA hsa-miR-33a-3p LEF1 1.72765312072219 1.51784443453521e-07 0.331269268157301 0.289787632933989 miRNATAP -0.161646083992726 0.00116798280053409 NA NA NA hsa-miR-125b-2-3p LIMD1 -1.83175829351767 2.94917958974528e-05 0.487304759021365 0.00435961861280182 mirMAP -0.129891230890113 3.13269270496586e-12 NA NA NA hsa-miR-132-3p LIMD1 0.156276992635384 0.408190812100704 0.487304759021365 0.00435961861280182 mirMAP -0.122150330283654 0.0059494567823473 NA NA NA hsa-miR-143-3p LIMD1 -2.5789192793377 1.55518999614836e-14 0.487304759021365 0.00435961861280182 mirMAP -0.107766742915083 5.44163804930862e-06 NA NA NA hsa-miR-146b-5p LIMD1 1.75587235896724 1.15724631266659e-07 0.487304759021365 0.00435961861280182 mirMAP -0.161435404242853 2.13719369029113e-11 NA NA NA hsa-miR-155-5p LIMD1 1.20164021433135 0.00086170622431261 0.487304759021365 0.00435961861280182 mirMAP -0.131225624481856 5.39423966808203e-09 NA NA NA hsa-miR-199a-3p LIMD1 0.640600337515787 0.0380326905134914 0.487304759021365 0.00435961861280182 mirMAP -0.183063287409296 2.73702040372648e-12 NA NA NA hsa-miR-199a-5p LIMD1 0.592984035153911 0.0674836634175293 0.487304759021365 0.00435961861280182 miRanda -0.120367186811716 1.99566433519741e-06 NA NA NA hsa-miR-199b-3p LIMD1 0.643923492750702 0.0371742251925406 0.487304759021365 0.00435961861280182 mirMAP -0.182855659566761 2.7988480103527e-12 NA NA NA hsa-miR-199b-5p LIMD1 0.218704279044827 0.519493319158441 0.487304759021365 0.00435961861280182 miRanda -0.105384169429996 1.40815070060411e-05 NA NA NA hsa-miR-212-3p LIMD1 0.357878936470387 0.232446214501331 0.487304759021365 0.00435961861280182 mirMAP -0.131240510778726 2.03092138526429e-06 NA NA NA hsa-miR-2355-5p LIMD1 1.32510310704724 8.25139516692683e-07 0.487304759021365 0.00435961861280182 mirMAP -0.125620296803794 3.48138028923911e-05 NA NA NA hsa-miR-382-5p LIMD1 0.545586518720593 0.0621058523772996 0.487304759021365 0.00435961861280182 mirMAP -0.140521177640286 5.56331259152945e-07 NA NA NA hsa-miR-485-3p LIMD1 0.442820096243914 0.166634696770945 0.487304759021365 0.00435961861280182 PITA;mirMAP -0.103582761908046 6.78035870121468e-05 NA NA NA hsa-miR-146b-3p LLGL2 1.10569195233795 0.000660632782194023 1.68800741352812 6.2903837425955e-08 miRNATAP -0.261257267345394 1.74847833796912e-08 NA NA NA hsa-miR-140-3p MPP5 0.0608890720479334 0.727716871248724 -0.26222079257503 0.0658846907584883 PITA -0.170292370175486 1.8162324989665e-05 NA NA NA hsa-miR-140-5p MPP5 0.844753502512594 3.73722278438606e-05 -0.26222079257503 0.0658846907584883 miRanda -0.115737023362252 0.000554223806366612 NA NA NA hsa-miR-181a-5p MPP5 2.29556023480783 1.8138457900616e-21 -0.26222079257503 0.0658846907584883 MirTarget -0.112883249096287 3.05745166313403e-05 NA NA NA hsa-miR-199a-5p MPP5 0.592984035153911 0.0674836634175293 -0.26222079257503 0.0658846907584883 MirTarget;PITA;miRanda;miRNATAP -0.107553822794879 2.97658493834631e-07 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-let-7a-5p NKD1 0.618599506841644 2.76973453058748e-05 -1.69553775455222 4.2654677240011e-05 TargetScan -0.412393121442761 0.00297883843016037 NA NA NA hsa-miR-140-5p NKD1 0.844753502512594 3.73722278438606e-05 -1.69553775455222 4.2654677240011e-05 miRanda -0.379888847864967 0.000112585187849131 NA NA NA hsa-miR-188-5p NKD1 2.52825126596644 6.78099435999778e-14 -1.69553775455222 4.2654677240011e-05 PITA;miRNATAP -0.25778755790971 2.85927171482183e-05 NA NA NA hsa-miR-200b-3p NKD1 3.78235093249346 3.18343003239465e-14 -1.69553775455222 4.2654677240011e-05 TargetScan -0.138663429173362 0.000391152627853839 NA NA NA hsa-miR-21-5p NKD1 2.73773305747971 1.38864982139576e-43 -1.69553775455222 4.2654677240011e-05 mirMAP -0.242774511306372 0.00882769312079821 NA NA NA hsa-miR-330-5p NKD1 1.15100069700871 4.85551805046014e-07 -1.69553775455222 4.2654677240011e-05 miRanda;miRNATAP -0.255318110723475 0.00362539046247924 NA NA NA hsa-miR-361-5p NKD1 0.971859117235239 5.30236555707088e-09 -1.69553775455222 4.2654677240011e-05 miRanda -0.661066416940325 3.2521696823557e-08 NA NA NA hsa-miR-421 NKD1 1.17791565395543 6.78526676976629e-06 -1.69553775455222 4.2654677240011e-05 mirMAP -0.208279535015449 0.00680685931469785 NA NA NA hsa-miR-429 NKD1 4.48815175680773 2.44117492218206e-17 -1.69553775455222 4.2654677240011e-05 miRanda;miRNATAP -0.131409348751771 0.000313269516977655 NA NA NA hsa-miR-501-5p NKD1 1.93654809410041 1.3779381780759e-10 -1.69553775455222 4.2654677240011e-05 mirMAP -0.28165045795111 2.7945839052911e-05 NA NA NA hsa-miR-532-5p NKD1 1.55697650978597 1.57884735535196e-11 -1.69553775455222 4.2654677240011e-05 PITA;miRNATAP -0.414476725623264 1.11427017775432e-06 NA NA NA hsa-miR-944 NKD1 2.91186649218281 1.31574753528144e-06 -1.69553775455222 4.2654677240011e-05 PITA;miRNATAP -0.158771499517632 2.84615119182641e-06 NA NA NA hsa-miR-146b-3p PARD6A 1.10569195233795 0.000660632782194023 0.0640925020545766 0.831704203185148 miRNATAP -0.184675100692129 3.22422549840886e-05 NA NA NA hsa-let-7c-5p PARD6B -2.07847142524506 5.51224567263294e-09 0.905678148394889 0.00279261418677908 MirTarget -0.124719036982838 0.00206125292832335 NA NA NA hsa-miR-223-3p PARD6B 0.390350910791999 0.345956164976892 0.905678148394889 0.00279261418677908 MirTarget -0.141523651567793 6.20052513936893e-05 NA NA NA hsa-miR-130a-3p PARD6G 2.02021855058359 1.26427102520415e-11 0.101424694528157 0.694724780229806 mirMAP -0.10779189386511 0.00839334084057809 NA NA NA hsa-miR-142-5p PARD6G 1.17581605694506 0.0018174701991234 0.101424694528157 0.694724780229806 mirMAP -0.128747872988869 8.65499908130038e-05 NA NA NA hsa-miR-146b-5p PARD6G 1.75587235896724 1.15724631266659e-07 0.101424694528157 0.694724780229806 miRanda -0.215333933515656 3.85379009352259e-09 NA NA NA hsa-let-7a-3p PPP1CB 1.42015538786275 7.03375209382654e-13 -0.820942153588652 7.14440139700139e-11 mirMAP -0.133349652802733 1.32581400571877e-05 NA NA NA hsa-miR-126-5p PPP1CB 0.895338176458417 2.33372756450713e-05 -0.820942153588652 7.14440139700139e-11 mirMAP -0.181091201929344 3.15178564841737e-10 NA NA NA hsa-miR-140-3p PPP1CB 0.0608890720479334 0.727716871248724 -0.820942153588652 7.14440139700139e-11 miRNATAP -0.195774976154139 3.90442194509849e-08 NA NA NA hsa-miR-140-5p PPP1CB 0.844753502512594 3.73722278438606e-05 -0.820942153588652 7.14440139700139e-11 miRanda -0.16641705160901 2.69404590531662e-08 NA NA NA hsa-miR-16-2-3p PPP1CB 2.31623086727196 4.29838149388188e-20 -0.820942153588652 7.14440139700139e-11 mirMAP -0.138876938214266 2.11927690814766e-09 NA NA NA hsa-miR-181a-5p PPP1CB 2.29556023480783 1.8138457900616e-21 -0.820942153588652 7.14440139700139e-11 mirMAP;miRNATAP -0.209205780504729 7.51030901712724e-19 NA NA NA hsa-miR-181b-5p PPP1CB 2.49307679431293 3.92829250217627e-20 -0.820942153588652 7.14440139700139e-11 mirMAP;miRNATAP -0.150661109695009 1.78007057078454e-12 NA NA NA hsa-miR-181c-5p PPP1CB 1.58587920618301 1.57506918816933e-10 -0.820942153588652 7.14440139700139e-11 mirMAP;miRNATAP -0.149561357345733 6.1928774726052e-10 NA NA NA hsa-miR-186-5p PPP1CB 1.47445398888668 3.0781726595413e-15 -0.820942153588652 7.14440139700139e-11 miRNATAP -0.145367134911331 6.45765750792465e-06 NA NA NA hsa-miR-320a PPP1CB 0.438165828017084 0.0390159073347133 -0.820942153588652 7.14440139700139e-11 miRNATAP -0.166050671034484 1.08723619462909e-08 NA NA NA hsa-miR-338-3p PPP1CB 0.453166438193782 0.144583389707558 -0.820942153588652 7.14440139700139e-11 PITA;miRanda -0.100669584272472 3.77076127634113e-07 NA NA NA hsa-miR-455-5p PPP1CB 2.2582442061694 1.43472128037398e-13 -0.820942153588652 7.14440139700139e-11 PITA;miRanda -0.123509182449495 1.84291494825741e-10 NA NA NA hsa-miR-484 PPP1CB 1.81844463411787 1.82951571230938e-15 -0.820942153588652 7.14440139700139e-11 miRNATAP -0.140668085509076 6.6854146123032e-08 NA NA NA hsa-miR-505-3p PPP1CB 1.45322244209148 8.86597629645867e-10 -0.820942153588652 7.14440139700139e-11 miRNAWalker2_validate -0.111323301802687 1.4114249196655e-05 NA NA NA hsa-miR-590-3p PPP1CB 2.59289455139753 1.03200520972022e-21 -0.820942153588652 7.14440139700139e-11 PITA;miRanda;mirMAP -0.103541471408296 3.32597274359754e-06 NA NA NA hsa-miR-590-5p PPP1CB 3.18300989862077 2.06813568597893e-26 -0.820942153588652 7.14440139700139e-11 miRanda -0.106193171348517 8.1020659105829e-08 NA NA NA hsa-miR-664a-3p PPP1CB 0.634721925861133 0.00520070178640421 -0.820942153588652 7.14440139700139e-11 mirMAP -0.183788558341913 7.24245562717809e-12 NA NA NA hsa-miR-183-5p PPP2CB 4.19757025992371 4.79612296318304e-26 -0.783679156108793 2.67817932533534e-08 MirTarget;miRNATAP -0.115935862473986 2.8039910681077e-13 NA NA NA hsa-miR-32-3p PPP2CB 2.02436999565685 5.94091197945307e-09 -0.783679156108793 2.67817932533534e-08 MirTarget -0.105750464768045 1.64351977471817e-06 NA NA NA hsa-miR-361-5p PPP2CB 0.971859117235239 5.30236555707088e-09 -0.783679156108793 2.67817932533534e-08 miRanda -0.206656922572491 4.60021445788998e-07 NA NA NA hsa-miR-425-5p PPP2CB 3.07071373939774 4.02947460586085e-25 -0.783679156108793 2.67817932533534e-08 miRNAWalker2_validate -0.185494581813071 1.46832581012673e-18 NA NA NA hsa-let-7d-5p PPP2R2A 1.33236798905207 1.1741085658466e-13 -0.403063589569943 0.0064064984207387 miRNATAP -0.135297179368885 0.000528587919196092 NA NA NA hsa-miR-450b-5p PPP2R2A 1.69244418548325 1.68064054148881e-10 -0.403063589569943 0.0064064984207387 PITA;mirMAP -0.106495945788614 5.33666403736845e-05 NA NA NA hsa-miR-126-5p PPP2R2B 0.895338176458417 2.33372756450713e-05 -2.25289619507804 0.000180435522352838 MirTarget -0.383045353036009 0.00567656859840651 NA NA NA hsa-miR-496 PPP2R2B 0.46914638405371 0.145980484291736 -2.25289619507804 0.000180435522352838 miRanda -0.371263243837406 6.11288048587766e-05 NA NA NA hsa-miR-7-1-3p PPP2R2B 1.84950311431067 1.25300363397654e-13 -2.25289619507804 0.000180435522352838 mirMAP -0.513497586532207 6.22874268961141e-06 NA NA NA hsa-miR-125a-3p PPP2R2C 1.24490295132072 5.26925231010328e-06 -0.795459846555288 0.266159255773917 miRanda -0.490921209474882 8.8742252357981e-05 NA NA NA hsa-miR-148b-5p PPP2R2C 2.18024067300781 2.84770452413262e-14 -0.795459846555288 0.266159255773917 mirMAP -0.480420136087959 9.92487765697059e-05 NA NA NA hsa-miR-181a-2-3p PPP2R2C 2.19062681262366 3.81790102612782e-13 -0.795459846555288 0.266159255773917 MirTarget -0.448111912961894 5.46490075193365e-05 NA NA NA hsa-miR-181b-5p PPP2R2C 2.49307679431293 3.92829250217627e-20 -0.795459846555288 0.266159255773917 mirMAP -0.485726885522172 6.359913390984e-05 NA NA NA hsa-miR-194-5p PPP2R2C 1.8992998339217 3.76507853301977e-10 -0.795459846555288 0.266159255773917 miRNATAP -0.360529551006111 0.00125231259350066 NA NA NA hsa-miR-200b-3p PPP2R2C 3.78235093249346 3.18343003239465e-14 -0.795459846555288 0.266159255773917 TargetScan -0.307390894454467 3.90674354552055e-06 NA NA NA hsa-miR-200c-3p PPP2R2C 3.50132673580082 2.42716349086937e-15 -0.795459846555288 0.266159255773917 miRNATAP -0.306291787073106 4.49365552911052e-05 NA NA NA hsa-miR-320a PPP2R2C 0.438165828017084 0.0390159073347133 -0.795459846555288 0.266159255773917 MirTarget;PITA;miRanda;miRNATAP -0.676342096282759 3.47297419282436e-05 NA NA NA hsa-miR-339-5p PPP2R2C 2.68710938429893 3.03134080808154e-16 -0.795459846555288 0.266159255773917 miRanda -0.288702394532432 0.00443412645568505 NA NA NA hsa-miR-429 PPP2R2C 4.48815175680773 2.44117492218206e-17 -0.795459846555288 0.266159255773917 PITA;miRanda;miRNATAP -0.269422401877531 1.4787975278128e-05 NA NA NA hsa-miR-500a-3p PPP2R2C 1.47161373123699 5.30571342631915e-09 -0.795459846555288 0.266159255773917 MirTarget -0.382661637452168 0.00470212406471155 NA NA NA hsa-miR-501-3p PPP2R2C 1.83132758513743 1.10971547702065e-10 -0.795459846555288 0.266159255773917 MirTarget;PITA;TargetScan;miRNATAP -0.398000149688683 0.000844564732429004 NA NA NA hsa-miR-502-3p PPP2R2C 1.50560877085049 1.2647489756373e-11 -0.795459846555288 0.266159255773917 MirTarget;PITA;miRNATAP -0.546851224300787 0.000333321417808122 NA NA NA hsa-miR-140-3p PRKCI 0.0608890720479334 0.727716871248724 0.380971498919253 0.0140815954838336 PITA -0.152870251911974 0.000439812287675818 NA NA NA hsa-miR-152-3p PRKCZ -0.0480232621705712 0.844347735441565 1.78785737460806 6.93304821938799e-13 MirTarget -0.189660072380916 0.00018972316398586 NA NA NA hsa-miR-744-5p RASSF1 1.48254348878737 3.23019501613577e-09 -0.255772087445639 0.107838711733709 miRNAWalker2_validate -0.103430119845104 0.000599862437988885 NA NA NA hsa-miR-132-3p RASSF6 0.156276992635384 0.408190812100704 0.776682132875306 0.147343585446835 mirMAP -0.390941824909055 0.00495316835906389 NA NA NA hsa-miR-212-3p RASSF6 0.357878936470387 0.232446214501331 0.776682132875306 0.147343585446835 mirMAP -0.262740439218187 0.00260336782931894 NA NA NA hsa-miR-338-3p RASSF6 0.453166438193782 0.144583389707558 0.776682132875306 0.147343585446835 miRanda -0.222619043389308 0.00781938145195191 NA NA NA hsa-miR-103a-3p SAV1 1.44083190496858 1.53799939616416e-13 -0.303251103809696 0.0442199438642061 miRNAWalker2_validate -0.204036609442502 1.50063242676231e-08 NA NA NA hsa-miR-107 SAV1 1.30977326593435 1.30372468603965e-11 -0.303251103809696 0.0442199438642061 PITA;miRanda;miRNATAP -0.128016203204014 0.000534810205448621 NA NA NA hsa-miR-126-5p SAV1 0.895338176458417 2.33372756450713e-05 -0.303251103809696 0.0442199438642061 mirMAP -0.153447979726066 6.8507257960355e-06 NA NA NA hsa-miR-186-5p SAV1 1.47445398888668 3.0781726595413e-15 -0.303251103809696 0.0442199438642061 mirMAP -0.157575677885371 3.10349112533924e-05 NA NA NA hsa-miR-320a SAV1 0.438165828017084 0.0390159073347133 -0.303251103809696 0.0442199438642061 miRanda -0.158393041011407 3.78217247557335e-06 NA NA NA hsa-miR-484 SAV1 1.81844463411787 1.82951571230938e-15 -0.303251103809696 0.0442199438642061 miRNAWalker2_validate -0.144889834603117 2.27277157560636e-06 NA NA NA hsa-miR-664a-3p SAV1 0.634721925861133 0.00520070178640421 -0.303251103809696 0.0442199438642061 mirMAP -0.283136567423742 3.28657654710374e-20 NA NA NA hsa-miR-129-5p SERPINE1 -0.524170159980738 0.222582956006346 -0.393407117230654 0.370425399232706 miRanda -0.169701923663541 0.000735839704611328 NA NA NA hsa-miR-148a-5p SERPINE1 1.16173838132242 0.000148929299881612 -0.393407117230654 0.370425399232706 miRNATAP -0.285071111266077 3.2328150503793e-05 NA NA NA hsa-miR-2110 SERPINE1 1.16625590651194 6.4784195289885e-05 -0.393407117230654 0.370425399232706 miRNATAP -0.312861484463966 5.27602364952907e-05 NA NA NA hsa-miR-301a-3p SERPINE1 2.81024345929638 2.29784847962242e-17 -0.393407117230654 0.370425399232706 miRNAWalker2_validate;miRTarBase -0.298339721528262 3.88735440627883e-06 NA NA NA hsa-miR-30b-5p SERPINE1 0.800822374912712 0.000133601914525413 -0.393407117230654 0.370425399232706 MirTarget -0.589742716683692 3.53023994480113e-09 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 0.778774633108 0.000285599212429136 -0.393407117230654 0.370425399232706 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.50652750448866 2.38346715661289e-07 NA NA NA hsa-miR-30d-5p SERPINE1 0.675423997639582 0.00270618816039773 -0.393407117230654 0.370425399232706 miRNATAP -0.643924984116999 3.16202278334948e-12 NA NA NA hsa-miR-378a-5p SERPINE1 0.223456081148306 0.386368843153575 -0.393407117230654 0.370425399232706 MirTarget -0.404559892121807 7.98544569711981e-07 NA NA NA hsa-miR-421 SERPINE1 1.17791565395543 6.78526676976629e-06 -0.393407117230654 0.370425399232706 miRanda -0.395794324632837 7.58532570850472e-07 NA NA NA hsa-miR-425-5p SERPINE1 3.07071373939774 4.02947460586085e-25 -0.393407117230654 0.370425399232706 MirTarget;miRNATAP -0.268582077948886 6.45365175266955e-05 NA NA NA hsa-miR-590-3p SERPINE1 2.59289455139753 1.03200520972022e-21 -0.393407117230654 0.370425399232706 miRanda -0.275014479514724 0.000327361176519488 NA NA NA hsa-miR-769-5p SERPINE1 1.82023760596845 9.6815886564134e-14 -0.393407117230654 0.370425399232706 MirTarget;miRNATAP -0.571996036825274 4.60171798625337e-12 NA NA NA hsa-miR-942-5p SERPINE1 2.35195531153712 5.45059325728841e-16 -0.393407117230654 0.370425399232706 MirTarget -0.197923564863346 0.00510222008258954 NA NA NA hsa-miR-26b-5p SMAD1 0.885393662798425 3.2116297961629e-06 -0.109343978474048 0.484396115391152 MirTarget -0.160417687044586 4.77036483505897e-05 25761878;27027434 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1;Twist1 related miR 26b 5p suppresses epithelial mesenchymal transition migration and invasion by targeting SMAD1 in hepatocellular carcinoma; Subsequent investigation revealed that miR-26b-5p directly inhibited SMAD family member 1 SMAD1 expression; miR-26b-5p repressed BMP4/Smad1 signaling following SMAD1 inhibition; Overexpression of SMAD1 reversed the function of miR-26b-5p; In human HCC tissues and mouse xenograft tumors miR-26b-5p levels were inversely correlated with SMAD1 expression as well as metastasis; miR-26b-5p suppresses Twist1-induced EMT invasion and metastasis of HCC cells by targeting SMAD1 and BMP4/Smad1 signaling ;metastasis sarcoma;liver cancer hsa-miR-30b-5p SMAD1 0.800822374912712 0.000133601914525413 -0.109343978474048 0.484396115391152 miRNAWalker2_validate;miRTarBase -0.160718917203476 6.90626781792677e-06 NA NA NA hsa-miR-30c-5p SMAD1 0.778774633108 0.000285599212429136 -0.109343978474048 0.484396115391152 miRNAWalker2_validate;miRTarBase -0.188361723191194 5.8391318593494e-08 NA NA NA hsa-miR-30d-5p SMAD1 0.675423997639582 0.00270618816039773 -0.109343978474048 0.484396115391152 miRNAWalker2_validate;miRTarBase -0.133891706488833 6.12990315600052e-05 NA NA NA hsa-miR-181a-5p SMAD2 2.29556023480783 1.8138457900616e-21 -0.217872679367038 0.049686680004959 mirMAP -0.112519930018506 7.12492899365623e-08 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 2.49307679431293 3.92829250217627e-20 -0.217872679367038 0.049686680004959 mirMAP -0.102985568847665 2.98550912982442e-08 NA NA NA hsa-miR-26a-5p SMAD2 0.0464832722967259 0.752628386912329 -0.217872679367038 0.049686680004959 mirMAP -0.11130754251612 0.0026935683249941 NA NA NA hsa-miR-361-3p SMAD2 1.07367425434318 1.73142774168958e-09 -0.217872679367038 0.049686680004959 miRNATAP -0.114638945395339 0.000110242156000821 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-let-7a-2-3p SMAD3 0.0400317820791161 0.91528727576685 -0.145068391221315 0.569239559252949 mirMAP -0.127624470471724 0.000115244641159406 NA NA NA hsa-miR-125b-2-3p SMAD3 -1.83175829351767 2.94917958974528e-05 -0.145068391221315 0.569239559252949 mirMAP -0.167358601156691 2.00437048846808e-09 NA NA NA hsa-miR-127-5p SMAD3 1.19850695520181 4.10976607177645e-05 -0.145068391221315 0.569239559252949 mirMAP -0.175774439508378 2.40422906256706e-05 NA NA NA hsa-miR-132-3p SMAD3 0.156276992635384 0.408190812100704 -0.145068391221315 0.569239559252949 mirMAP -0.307625427852275 2.61092084929535e-06 NA NA NA hsa-miR-142-5p SMAD3 1.17581605694506 0.0018174701991234 -0.145068391221315 0.569239559252949 PITA -0.121783193917905 0.000168543842540946 NA NA NA hsa-miR-145-5p SMAD3 -1.55259331973517 9.97889123247165e-07 -0.145068391221315 0.569239559252949 MirTarget;miRNATAP -0.102333497957109 0.0076425159078547 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 1.20164021433135 0.00086170622431261 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.167586664196246 6.20173080978562e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-188-5p SMAD3 2.52825126596644 6.78099435999778e-14 -0.145068391221315 0.569239559252949 PITA -0.184950370967834 7.35063541952032e-07 NA NA NA hsa-miR-18a-5p SMAD3 3.78535678765353 3.72446596213886e-26 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.136878014915373 5.63544047470077e-05 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-195-5p SMAD3 -1.44753678070504 8.70594292149271e-09 -0.145068391221315 0.569239559252949 MirTarget -0.155082880098317 0.00129697117488075 27206216 MiR 195 Suppresses Cervical Cancer Migration and Invasion Through Targeting Smad3; The purposes of this study were to investigate the role of miR-195 in cervical cancer and clarify the regulation of Smad3 by miR-195; Smad3 was verified as a direct target of miR-195 which was further confirmed by the inverse expression of miR-195 and Smad3 in patients' specimens cervical and endocervical cancer hsa-miR-212-3p SMAD3 0.357878936470387 0.232446214501331 -0.145068391221315 0.569239559252949 mirMAP -0.196270501722139 1.760966299711e-06 NA NA NA hsa-miR-326 SMAD3 0.715313016136042 0.0610265683213359 -0.145068391221315 0.569239559252949 miRanda -0.127854658986735 7.18944162313972e-05 NA NA NA hsa-miR-424-5p SMAD3 1.61930224569578 1.89642549274994e-10 -0.145068391221315 0.569239559252949 MirTarget -0.137637867799144 0.0037931514509118 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-485-3p SMAD3 0.442820096243914 0.166634696770945 -0.145068391221315 0.569239559252949 MirTarget -0.146973333951251 0.000145374061338494 NA NA NA hsa-miR-495-3p SMAD3 -0.0847115949846082 0.763475496144456 -0.145068391221315 0.569239559252949 mirMAP -0.147079833458788 0.000814867470605654 NA NA NA hsa-miR-497-5p SMAD3 0.0257087130056286 0.918145413833358 -0.145068391221315 0.569239559252949 MirTarget -0.149416186909323 0.00253073754447704 NA NA NA hsa-miR-501-5p SMAD3 1.93654809410041 1.3779381780759e-10 -0.145068391221315 0.569239559252949 mirMAP -0.178593095060563 1.2547872342843e-05 NA NA NA hsa-miR-589-3p SMAD3 2.51971841868825 2.39125940264107e-11 -0.145068391221315 0.569239559252949 mirMAP -0.112359264624293 0.0019298395243008 NA NA NA hsa-let-7f-1-3p SMAD4 1.55054488387679 7.31326775537952e-11 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106405479232356 4.39371133743738e-05 NA NA NA hsa-miR-140-5p SMAD4 0.844753502512594 3.73722278438606e-05 -0.586921155134023 3.52416916552263e-06 miRanda -0.114517150132142 0.000134319769998401 NA NA NA hsa-miR-146b-5p SMAD4 1.75587235896724 1.15724631266659e-07 -0.586921155134023 3.52416916552263e-06 PITA;miRanda;miRNATAP -0.103959435086478 8.75874581151263e-09 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-186-5p SMAD4 1.47445398888668 3.0781726595413e-15 -0.586921155134023 3.52416916552263e-06 miRNAWalker2_validate;mirMAP -0.107040467643529 0.000873099593755318 NA NA NA hsa-miR-2355-5p SMAD4 1.32510310704724 8.25139516692683e-07 -0.586921155134023 3.52416916552263e-06 MirTarget -0.100237269384076 8.83439826066143e-06 NA NA NA hsa-miR-26b-5p SMAD4 0.885393662798425 3.2116297961629e-06 -0.586921155134023 3.52416916552263e-06 MirTarget;miRNATAP -0.101564603889141 0.00171580634002753 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 1.66542180327138 4.93775737894805e-13 -0.586921155134023 3.52416916552263e-06 MirTarget -0.13536279837513 1.62491622147447e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.9016323452565 1.43092834643601e-14 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.121709073519824 3.8975183335493e-07 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-362-3p SMAD4 2.0756816987665 3.89026064579331e-12 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.105074125190041 3.2218791406447e-07 NA NA NA hsa-miR-576-5p SMAD4 2.20467023993664 3.4053475193793e-19 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106133513564488 8.78863207489382e-06 NA NA NA hsa-miR-103a-3p SMAD7 1.44083190496858 1.53799939616416e-13 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.259342276341149 1.42207366057362e-06 NA NA NA hsa-miR-106a-5p SMAD7 2.48882002962836 1.99757727374521e-12 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.125254691617488 2.22681317473832e-05 NA NA NA hsa-miR-106b-5p SMAD7 2.46782146831112 1.36171495805632e-23 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.277320790302171 9.3034900627467e-12 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-15a-5p SMAD7 2.34669284378787 1.69544424500258e-23 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.159261254747071 0.00025730933802413 NA NA NA hsa-miR-15b-5p SMAD7 1.57112623124278 9.14247846750597e-13 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.31270512309151 3.09745138070762e-11 NA NA NA hsa-miR-16-5p SMAD7 1.75824877145857 1.68592440033108e-16 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.268581547269042 3.03392557940829e-08 NA NA NA hsa-miR-17-5p SMAD7 3.2710598467455 9.93128340539455e-27 -1.18986730797292 6.37278457783496e-08 TargetScan;miRNATAP -0.179045141842203 4.62928621050582e-08 NA NA NA hsa-miR-182-5p SMAD7 3.53923166221814 5.07781258121574e-21 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.139835996687329 2.24704056840338e-07 NA NA NA hsa-miR-185-3p SMAD7 2.3922478518806 1.3373426768452e-14 -1.18986730797292 6.37278457783496e-08 MirTarget -0.16019453105202 1.61560898647719e-06 NA NA NA hsa-miR-200b-3p SMAD7 3.78235093249346 3.18343003239465e-14 -1.18986730797292 6.37278457783496e-08 TargetScan;mirMAP -0.111551767935926 6.99585057787961e-08 NA NA NA hsa-miR-20a-5p SMAD7 3.15577933619191 4.19753346442454e-25 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.160049327078402 1.33417399732611e-06 NA NA NA hsa-miR-20b-5p SMAD7 2.07706563022469 1.10107236083433e-05 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.110638066003306 7.64101248507177e-07 NA NA NA hsa-miR-21-3p SMAD7 2.19296355304364 4.63665722759779e-15 -1.18986730797292 6.37278457783496e-08 MirTarget -0.111091823108787 0.0029631409368765 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-25-3p SMAD7 1.36472605225697 4.83790725935681e-11 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.32459267218806 1.06984918886287e-10 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer colon cancer hsa-miR-26b-5p SMAD7 0.885393662798425 3.2116297961629e-06 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.153719560363337 0.00686506683647215 NA NA NA hsa-miR-3065-5p SMAD7 2.74629919868982 1.86846589298284e-08 -1.18986730797292 6.37278457783496e-08 mirMAP -0.189760432676296 2.54459807792449e-13 NA NA NA hsa-miR-32-5p SMAD7 2.34056473219422 6.24134585974322e-20 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.193932841483501 1.28093315805443e-06 NA NA NA hsa-miR-324-3p SMAD7 2.08739139768981 3.11885987067952e-13 -1.18986730797292 6.37278457783496e-08 MirTarget -0.213445619719733 3.49943456935247e-09 NA NA NA hsa-miR-330-3p SMAD7 0.876747334239085 0.00073709016089703 -1.18986730797292 6.37278457783496e-08 PITA;miRNATAP -0.131059927114688 0.00158540861178329 NA NA NA hsa-miR-340-5p SMAD7 0.30282999308409 0.157744789519131 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.23974541892437 1.96057225251223e-06 NA NA NA hsa-miR-34a-5p SMAD7 1.9016323452565 1.43092834643601e-14 -1.18986730797292 6.37278457783496e-08 MirTarget -0.136694424476981 0.00127398242742499 NA NA NA hsa-miR-363-3p SMAD7 1.50575300026701 0.00020976164678918 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.128264808705891 9.56521837005215e-07 NA NA NA hsa-miR-374b-3p SMAD7 0.930487774873495 2.74420094310516e-05 -1.18986730797292 6.37278457783496e-08 MirTarget -0.156200309599714 0.00134771152654086 NA NA NA hsa-miR-590-3p SMAD7 2.59289455139753 1.03200520972022e-21 -1.18986730797292 6.37278457783496e-08 miRanda -0.222506648161791 7.31039792477637e-09 NA NA NA hsa-miR-590-5p SMAD7 3.18300989862077 2.06813568597893e-26 -1.18986730797292 6.37278457783496e-08 MirTarget;PITA;miRanda;miRNATAP -0.210186244146202 8.48093543573176e-10 NA NA NA hsa-miR-671-5p SMAD7 2.97733652243246 1.21148452344738e-23 -1.18986730797292 6.37278457783496e-08 PITA -0.232453499061808 7.31832849987942e-11 NA NA NA hsa-miR-92a-3p SMAD7 2.06460102658973 1.44784291084757e-19 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.243515114080339 5.96198780654537e-08 NA NA NA hsa-miR-92b-3p SMAD7 1.20409245530001 3.41055816361655e-06 -1.18986730797292 6.37278457783496e-08 MirTarget;miRNATAP -0.194822895712289 2.03841347106112e-06 NA NA NA hsa-miR-93-5p SMAD7 3.03961860136032 1.11672209617395e-24 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.211234452180854 4.08827528617675e-10 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-96-5p SMAD7 4.89433085814374 1.92000659886961e-31 -1.18986730797292 6.37278457783496e-08 TargetScan;miRNATAP -0.138733388809805 8.79404813817033e-09 NA NA NA hsa-miR-98-5p SMAD7 1.11154309866014 1.24143909012085e-08 -1.18986730797292 6.37278457783496e-08 miRNAWalker2_validate -0.283857586571606 1.75254699511423e-07 NA NA NA hsa-miR-107 SNAI2 1.30977326593435 1.30372468603965e-11 -0.280307189347724 0.489884936104145 miRanda -0.587951478655937 2.23241515205897e-09 NA NA NA hsa-miR-148b-3p SNAI2 1.97815018171325 6.07715327281595e-26 -0.280307189347724 0.489884936104145 miRNAWalker2_validate -0.5115588617257 1.85198661011602e-07 NA NA NA hsa-miR-182-5p SNAI2 3.53923166221814 5.07781258121574e-21 -0.280307189347724 0.489884936104145 miRNAWalker2_validate;miRNATAP -0.226684880391696 4.11330558077327e-06 NA NA NA hsa-miR-200b-3p SNAI2 3.78235093249346 3.18343003239465e-14 -0.280307189347724 0.489884936104145 TargetScan -0.267184160966678 5.83468454644939e-13 NA NA NA hsa-miR-200c-3p SNAI2 3.50132673580082 2.42716349086937e-15 -0.280307189347724 0.489884936104145 miRNATAP -0.183480437180395 1.58844201912264e-05 NA NA NA hsa-miR-330-3p SNAI2 0.876747334239085 0.00073709016089703 -0.280307189347724 0.489884936104145 PITA -0.244344141932354 0.00118305093009477 NA NA NA hsa-miR-335-3p SNAI2 3.08791651139852 5.31309869723517e-12 -0.280307189347724 0.489884936104145 mirMAP -0.125422480922013 0.00324023238716861 NA NA NA hsa-miR-33a-3p SNAI2 1.72765312072219 1.51784443453521e-07 -0.280307189347724 0.489884936104145 MirTarget -0.326770909713066 3.29484348166007e-07 NA NA NA hsa-miR-375 SNAI2 1.13910305294079 0.0512283522214186 -0.280307189347724 0.489884936104145 miRanda -0.160294717693396 1.3349557949902e-06 NA NA NA hsa-miR-421 SNAI2 1.17791565395543 6.78526676976629e-06 -0.280307189347724 0.489884936104145 miRanda -0.277190656175256 0.000195037380670986 NA NA NA hsa-miR-429 SNAI2 4.48815175680773 2.44117492218206e-17 -0.280307189347724 0.489884936104145 PITA;miRanda;miRNATAP -0.243690996915046 1.98440445952138e-12 NA NA NA hsa-miR-532-5p SNAI2 1.55697650978597 1.57884735535196e-11 -0.280307189347724 0.489884936104145 PITA -0.570320787851888 2.40819282921953e-12 NA NA NA hsa-miR-96-5p SNAI2 4.89433085814374 1.92000659886961e-31 -0.280307189347724 0.489884936104145 miRNATAP -0.21174388168592 1.54578985770895e-06 NA NA NA hsa-miR-34a-5p SOX2 1.9016323452565 1.43092834643601e-14 -0.323595368728617 0.681514582034885 miRNAWalker2_validate;miRTarBase -0.418653713804836 0.00524040301276666 NA NA NA hsa-miR-125a-5p STK3 0.599529391575274 0.0102300147180307 0.157754074583901 0.310254102765732 miRanda -0.13587832062123 2.21374644392661e-05 NA NA NA hsa-miR-28-3p STK3 -0.411384408160536 0.0101470262574251 0.157754074583901 0.310254102765732 MirTarget;PITA -0.155202128918813 0.00109276407887798 NA NA NA hsa-miR-29b-2-5p STK3 0.910668640983475 0.00666655585493488 0.157754074583901 0.310254102765732 MirTarget -0.195013061955265 6.37818523255653e-20 NA NA NA hsa-miR-582-5p STK3 0.609226359812689 0.032988717891497 0.157754074583901 0.310254102765732 MirTarget -0.134638518110038 2.17281536954597e-07 NA NA NA hsa-miR-106a-5p TCF7L1 2.48882002962836 1.99757727374521e-12 -1.29563210038614 0.00022110689990566 MirTarget -0.237528555928573 3.23041076064227e-07 NA NA NA hsa-miR-106b-5p TCF7L1 2.46782146831112 1.36171495805632e-23 -1.29563210038614 0.00022110689990566 MirTarget -0.484981855840182 3.28026578455762e-14 NA NA NA hsa-miR-130b-5p TCF7L1 2.9963110846538 1.98883029416455e-18 -1.29563210038614 0.00022110689990566 MirTarget -0.271019550375905 2.2979535723062e-08 NA NA NA hsa-miR-141-3p TCF7L1 5.02396127982626 2.19224509139725e-24 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.292690799524826 5.33572896586791e-21 NA NA NA hsa-miR-15b-3p TCF7L1 2.33847028227712 4.29662877950836e-19 -1.29563210038614 0.00022110689990566 miRNATAP -0.300469437837364 1.27786211803164e-06 NA NA NA hsa-miR-17-5p TCF7L1 3.2710598467455 9.93128340539455e-27 -1.29563210038614 0.00022110689990566 MirTarget;TargetScan -0.232329734367548 8.28447631894401e-06 NA NA NA hsa-miR-185-3p TCF7L1 2.3922478518806 1.3373426768452e-14 -1.29563210038614 0.00022110689990566 MirTarget -0.264637899208463 5.26321085249236e-07 NA NA NA hsa-miR-200a-3p TCF7L1 4.59434485520731 6.38952518573476e-18 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.31712696382727 2.57417137844588e-28 NA NA NA hsa-miR-200b-3p TCF7L1 3.78235093249346 3.18343003239465e-14 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.344042033030514 1.2723812194927e-28 NA NA NA hsa-miR-200c-3p TCF7L1 3.50132673580082 2.42716349086937e-15 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.321512044267134 2.09544895880279e-19 NA NA NA hsa-miR-20a-5p TCF7L1 3.15577933619191 4.19753346442454e-25 -1.29563210038614 0.00022110689990566 MirTarget -0.255169684828929 1.08876064596683e-06 NA NA NA hsa-miR-20b-5p TCF7L1 2.07706563022469 1.10107236083433e-05 -1.29563210038614 0.00022110689990566 MirTarget -0.20708414684031 3.93831642070411e-09 NA NA NA hsa-miR-30b-3p TCF7L1 0.834142820354026 0.000972582820878813 -1.29563210038614 0.00022110689990566 MirTarget -0.334944599332039 6.20751141723943e-07 NA NA NA hsa-miR-30d-3p TCF7L1 0.977747550180601 4.3048212205381e-05 -1.29563210038614 0.00022110689990566 miRNATAP -0.376148637052463 9.58674800435899e-08 NA NA NA hsa-miR-330-5p TCF7L1 1.15100069700871 4.85551805046014e-07 -1.29563210038614 0.00022110689990566 miRanda -0.270812249528041 0.000249896592119458 NA NA NA hsa-miR-429 TCF7L1 4.48815175680773 2.44117492218206e-17 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.314442027101828 2.17867907624385e-27 NA NA NA hsa-miR-505-5p TCF7L1 1.89243395287645 9.82003586561819e-12 -1.29563210038614 0.00022110689990566 miRNATAP -0.254826466368037 2.03293000248315e-05 NA NA NA hsa-miR-590-3p TCF7L1 2.59289455139753 1.03200520972022e-21 -1.29563210038614 0.00022110689990566 PITA;miRanda;miRNATAP -0.231465745000028 0.000168980352397349 NA NA NA hsa-miR-93-5p TCF7L1 3.03961860136032 1.11672209617395e-24 -1.29563210038614 0.00022110689990566 MirTarget -0.400191107813803 3.80432743383064e-14 NA NA NA hsa-miR-155-5p TCF7L2 1.20164021433135 0.00086170622431261 -0.0989663661080726 0.582291209673574 MirTarget;miRNATAP -0.104003957059588 1.22170888051923e-05 NA NA NA hsa-miR-24-2-5p TCF7L2 2.07171035460647 3.15853539996136e-16 -0.0989663661080726 0.582291209673574 MirTarget -0.134437366020417 4.4418676957063e-05 NA NA NA hsa-miR-338-3p TCF7L2 0.453166438193782 0.144583389707558 -0.0989663661080726 0.582291209673574 miRanda -0.114047090229425 4.18397743027561e-05 NA NA NA hsa-let-7a-3p TEAD1 1.42015538786275 7.03375209382654e-13 -1.49495998391161 1.96516757915294e-13 MirTarget -0.275056000120155 2.89903982554734e-08 NA NA NA hsa-let-7b-3p TEAD1 0.868207752019623 1.30460056774366e-05 -1.49495998391161 1.96516757915294e-13 MirTarget -0.145955821957495 0.00411485591351124 NA NA NA hsa-miR-101-3p TEAD1 0.522819989585461 0.00375627731618038 -1.49495998391161 1.96516757915294e-13 mirMAP -0.344504387834282 6.26055174058587e-10 NA NA NA hsa-miR-101-5p TEAD1 0.782067874775122 0.00443725251526842 -1.49495998391161 1.96516757915294e-13 MirTarget;mirMAP -0.169538580820429 6.83211341798132e-06 NA NA NA hsa-miR-103a-3p TEAD1 1.44083190496858 1.53799939616416e-13 -1.49495998391161 1.96516757915294e-13 mirMAP -0.413380890532289 3.45861619170933e-17 NA NA NA hsa-miR-106a-5p TEAD1 2.48882002962836 1.99757727374521e-12 -1.49495998391161 1.96516757915294e-13 mirMAP -0.121407873183656 1.14372413963813e-05 NA NA NA hsa-miR-106b-5p TEAD1 2.46782146831112 1.36171495805632e-23 -1.49495998391161 1.96516757915294e-13 mirMAP -0.286393402034374 4.15832562774966e-14 NA NA NA hsa-miR-107 TEAD1 1.30977326593435 1.30372468603965e-11 -1.49495998391161 1.96516757915294e-13 mirMAP -0.196874253977923 0.000127071639293235 NA NA NA hsa-miR-10b-3p TEAD1 0.77597971642517 0.00264877454133753 -1.49495998391161 1.96516757915294e-13 mirMAP -0.267255020737485 3.06611653175838e-12 NA NA NA hsa-miR-126-5p TEAD1 0.895338176458417 2.33372756450713e-05 -1.49495998391161 1.96516757915294e-13 mirMAP -0.262734275936604 2.56626473348978e-08 NA NA NA hsa-miR-1271-5p TEAD1 0.970418832993172 0.000609742584380688 -1.49495998391161 1.96516757915294e-13 mirMAP -0.135798888995618 0.000137498625683239 NA NA NA hsa-miR-128-3p TEAD1 1.63756041666078 6.79626586407187e-14 -1.49495998391161 1.96516757915294e-13 MirTarget -0.260673799243507 4.86018508125881e-09 NA NA NA hsa-miR-130a-3p TEAD1 2.02021855058359 1.26427102520415e-11 -1.49495998391161 1.96516757915294e-13 mirMAP -0.136013839637384 3.74040724001517e-05 NA NA NA hsa-miR-130b-3p TEAD1 3.5350292994509 1.73934183852569e-27 -1.49495998391161 1.96516757915294e-13 mirMAP -0.169048128787841 3.80482139708262e-09 NA NA NA hsa-miR-140-3p TEAD1 0.0608890720479334 0.727716871248724 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.235869223339754 5.66634609990947e-05 NA NA NA hsa-miR-140-5p TEAD1 0.844753502512594 3.73722278438606e-05 -1.49495998391161 1.96516757915294e-13 PITA;miRanda;miRNATAP -0.211631995183254 1.67532508142447e-05 NA NA NA hsa-miR-141-3p TEAD1 5.02396127982626 2.19224509139725e-24 -1.49495998391161 1.96516757915294e-13 mirMAP -0.187805911792407 8.82877169341974e-25 NA NA NA hsa-miR-142-3p TEAD1 2.75247908790621 1.45636065474764e-12 -1.49495998391161 1.96516757915294e-13 MirTarget;PITA;miRNATAP -0.116773641993943 3.31218193154881e-06 NA NA NA hsa-miR-148a-3p TEAD1 1.26728238710376 2.52325607402829e-06 -1.49495998391161 1.96516757915294e-13 MirTarget;miRNATAP -0.25092971502087 5.83932372289035e-12 NA NA NA hsa-miR-148b-3p TEAD1 1.97815018171325 6.07715327281595e-26 -1.49495998391161 1.96516757915294e-13 MirTarget -0.417650488719579 2.59498644649086e-17 NA NA NA hsa-miR-151a-3p TEAD1 1.24018761527407 1.08839919675408e-07 -1.49495998391161 1.96516757915294e-13 mirMAP -0.169171481850785 7.70104143861011e-05 NA NA NA hsa-miR-15b-3p TEAD1 2.33847028227712 4.29662877950836e-19 -1.49495998391161 1.96516757915294e-13 mirMAP -0.230186531172977 2.61590316144476e-10 NA NA NA hsa-miR-16-1-3p TEAD1 2.56983217111073 3.02262181237943e-20 -1.49495998391161 1.96516757915294e-13 MirTarget;mirMAP -0.29601314469879 6.5878376653636e-18 NA NA NA hsa-miR-16-2-3p TEAD1 2.31623086727196 4.29838149388188e-20 -1.49495998391161 1.96516757915294e-13 mirMAP -0.282626681235513 3.83872514988838e-14 NA NA NA hsa-miR-17-5p TEAD1 3.2710598467455 9.93128340539455e-27 -1.49495998391161 1.96516757915294e-13 mirMAP -0.226675197665895 6.66389677644907e-14 NA NA NA hsa-miR-181a-2-3p TEAD1 2.19062681262366 3.81790102612782e-13 -1.49495998391161 1.96516757915294e-13 mirMAP -0.138022093055024 2.12549090222786e-05 NA NA NA hsa-miR-181a-5p TEAD1 2.29556023480783 1.8138457900616e-21 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.2692701459728 6.32609821443213e-12 NA NA NA hsa-miR-181b-5p TEAD1 2.49307679431293 3.92829250217627e-20 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.195366528104192 2.9494034138103e-08 NA NA NA hsa-miR-181c-5p TEAD1 1.58587920618301 1.57506918816933e-10 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.188818515441507 2.09248069678476e-06 NA NA NA hsa-miR-182-5p TEAD1 3.53923166221814 5.07781258121574e-21 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.208311227035654 3.08897671904962e-17 NA NA NA hsa-miR-185-5p TEAD1 2.34016206907488 1.17481626642022e-26 -1.49495998391161 1.96516757915294e-13 MirTarget;miRNATAP -0.337016437452661 1.54933019587286e-15 NA NA NA hsa-miR-186-5p TEAD1 1.47445398888668 3.0781726595413e-15 -1.49495998391161 1.96516757915294e-13 MirTarget -0.392858103785954 2.12209188312763e-14 NA NA NA hsa-miR-192-5p TEAD1 2.69002528723195 1.22990188194432e-16 -1.49495998391161 1.96516757915294e-13 mirMAP -0.156354611707829 1.37624924611464e-07 NA NA NA hsa-miR-194-5p TEAD1 1.8992998339217 3.76507853301977e-10 -1.49495998391161 1.96516757915294e-13 MirTarget -0.181266401864408 1.98768389322605e-08 NA NA NA hsa-miR-19a-3p TEAD1 3.42309334186656 3.02671914353412e-28 -1.49495998391161 1.96516757915294e-13 mirMAP -0.24158150890848 2.35657045039611e-16 NA NA NA hsa-miR-19b-3p TEAD1 2.49529833021187 1.57028265846699e-23 -1.49495998391161 1.96516757915294e-13 mirMAP -0.293009890848355 4.20967534426774e-15 NA NA NA hsa-miR-200a-3p TEAD1 4.59434485520731 6.38952518573476e-18 -1.49495998391161 1.96516757915294e-13 mirMAP -0.15151325299514 4.69815727845076e-18 NA NA NA hsa-miR-200a-5p TEAD1 3.86316681673704 1.81076942093171e-15 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.159600791320251 1.9021512150441e-16 NA NA NA hsa-miR-200b-3p TEAD1 3.78235093249346 3.18343003239465e-14 -1.49495998391161 1.96516757915294e-13 TargetScan -0.147875286208619 8.27108258370029e-15 NA NA NA hsa-miR-200c-3p TEAD1 3.50132673580082 2.42716349086937e-15 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.192783618175601 7.30243782570054e-20 NA NA NA hsa-miR-205-5p TEAD1 4.1389800495524 2.05488295686453e-12 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.148842008478 9.79462461102482e-21 NA NA NA hsa-miR-20a-5p TEAD1 3.15577933619191 4.19753346442454e-25 -1.49495998391161 1.96516757915294e-13 mirMAP -0.250132361627608 1.29384672064608e-16 NA NA NA hsa-miR-20b-5p TEAD1 2.07706563022469 1.10107236083433e-05 -1.49495998391161 1.96516757915294e-13 mirMAP -0.10691906892993 3.36897252294795e-07 NA NA NA hsa-miR-21-3p TEAD1 2.19296355304364 4.63665722759779e-15 -1.49495998391161 1.96516757915294e-13 mirMAP -0.14822797498695 2.11419551873822e-05 NA NA NA hsa-miR-22-5p TEAD1 1.88011544159252 1.63978222572222e-16 -1.49495998391161 1.96516757915294e-13 mirMAP -0.182008176318615 2.0881254963941e-05 NA NA NA hsa-miR-224-3p TEAD1 1.87536386559317 6.15140969394846e-05 -1.49495998391161 1.96516757915294e-13 mirMAP -0.101041847162928 5.79017460845617e-06 NA NA NA hsa-miR-23a-3p TEAD1 1.00493340843378 2.55313889288924e-08 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.206334803078793 0.000214754237591687 NA NA NA hsa-miR-25-3p TEAD1 1.36472605225697 4.83790725935681e-11 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.305349804818423 9.15825570849213e-11 NA NA NA hsa-miR-27a-3p TEAD1 1.66542180327138 4.93775737894805e-13 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.188181566811759 1.03131651281388e-05 NA NA NA hsa-miR-27b-3p TEAD1 0.196007704287769 0.295630157035388 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.141176393709149 0.00999060008987025 NA NA NA hsa-miR-29b-2-5p TEAD1 0.910668640983475 0.00666655585493488 -1.49495998391161 1.96516757915294e-13 MirTarget -0.22861424628451 5.05838104803862e-15 NA NA NA hsa-miR-29b-3p TEAD1 1.65828197923813 1.02676780888141e-09 -1.49495998391161 1.96516757915294e-13 mirMAP -0.260730788583564 2.76979913985072e-13 NA NA NA hsa-miR-29c-3p TEAD1 -0.00968972577705429 0.97099586346872 -1.49495998391161 1.96516757915294e-13 mirMAP -0.190384054697866 4.76736292361201e-07 NA NA NA hsa-miR-301a-3p TEAD1 2.81024345929638 2.29784847962242e-17 -1.49495998391161 1.96516757915294e-13 mirMAP -0.20302264907738 2.39727855557167e-11 NA NA NA hsa-miR-3065-3p TEAD1 2.16221780121195 9.65525739884541e-09 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.103044244048608 8.74647099110125e-05 NA NA NA hsa-miR-30d-3p TEAD1 0.977747550180601 4.3048212205381e-05 -1.49495998391161 1.96516757915294e-13 MirTarget -0.181985060495967 1.49743707778805e-05 NA NA NA hsa-miR-30e-3p TEAD1 -0.215663037684509 0.235375122783546 -1.49495998391161 1.96516757915294e-13 MirTarget -0.146108281948073 0.00978949116006427 NA NA NA hsa-miR-32-3p TEAD1 2.02436999565685 5.94091197945307e-09 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.118707869790646 0.000263195736007798 NA NA NA hsa-miR-32-5p TEAD1 2.34056473219422 6.24134585974322e-20 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.234969502871922 2.62429897741745e-10 NA NA NA hsa-miR-320a TEAD1 0.438165828017084 0.0390159073347133 -1.49495998391161 1.96516757915294e-13 miRNAWalker2_validate;mirMAP -0.290081020755601 8.1741273281024e-10 NA NA NA hsa-miR-320b TEAD1 1.55692969039548 1.41071034251915e-08 -1.49495998391161 1.96516757915294e-13 mirMAP -0.194701348651147 5.92973593054862e-08 NA NA NA hsa-miR-330-3p TEAD1 0.876747334239085 0.00073709016089703 -1.49495998391161 1.96516757915294e-13 MirTarget;PITA;miRNATAP -0.110880727313229 0.0044086250896823 NA NA NA hsa-miR-34a-3p TEAD1 1.75590866103657 8.02801510630657e-09 -1.49495998391161 1.96516757915294e-13 mirMAP -0.20122072275574 2.0870412367237e-08 NA NA NA hsa-miR-3607-3p TEAD1 2.68532138541128 5.66716351955047e-14 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.221507396805164 4.70314230923403e-16 NA NA NA hsa-miR-425-5p TEAD1 3.07071373939774 4.02947460586085e-25 -1.49495998391161 1.96516757915294e-13 mirMAP -0.30324426120978 3.28528400622428e-23 NA NA NA hsa-miR-429 TEAD1 4.48815175680773 2.44117492218206e-17 -1.49495998391161 1.96516757915294e-13 PITA;miRNATAP -0.141288841043744 1.61062605490045e-15 NA NA NA hsa-miR-454-3p TEAD1 2.47234127820054 1.12878018736016e-21 -1.49495998391161 1.96516757915294e-13 mirMAP -0.313927603125934 2.09131696033203e-17 NA NA NA hsa-miR-505-3p TEAD1 1.45322244209148 8.86597629645867e-10 -1.49495998391161 1.96516757915294e-13 mirMAP -0.241375309001833 5.74187988709282e-09 NA NA NA hsa-miR-532-5p TEAD1 1.55697650978597 1.57884735535196e-11 -1.49495998391161 1.96516757915294e-13 PITA;miRNATAP -0.23845105425673 1.91091714136202e-08 NA NA NA hsa-miR-576-5p TEAD1 2.20467023993664 3.4053475193793e-19 -1.49495998391161 1.96516757915294e-13 mirMAP -0.330139377666277 3.56165541732218e-18 NA NA NA hsa-miR-582-3p TEAD1 0.00876844181512659 0.977126166214707 -1.49495998391161 1.96516757915294e-13 mirMAP -0.160335450551014 1.10671756798913e-06 NA NA NA hsa-miR-582-5p TEAD1 0.609226359812689 0.032988717891497 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.21735979286295 4.48069939249756e-10 NA NA NA hsa-miR-590-3p TEAD1 2.59289455139753 1.03200520972022e-21 -1.49495998391161 1.96516757915294e-13 MirTarget;PITA;miRanda;miRNATAP -0.266044274584004 7.81006033810457e-14 NA NA NA hsa-miR-624-5p TEAD1 1.47043111118159 8.25080691741182e-09 -1.49495998391161 1.96516757915294e-13 mirMAP -0.129587446146166 0.00142692798245927 NA NA NA hsa-miR-629-5p TEAD1 2.10182419359635 1.51788571125757e-15 -1.49495998391161 1.96516757915294e-13 mirMAP -0.206164463412032 1.95256113811373e-08 NA NA NA hsa-miR-664a-3p TEAD1 0.634721925861133 0.00520070178640421 -1.49495998391161 1.96516757915294e-13 mirMAP -0.332889012012439 1.81637662572882e-14 NA NA NA hsa-miR-7-1-3p TEAD1 1.84950311431067 1.25300363397654e-13 -1.49495998391161 1.96516757915294e-13 mirMAP -0.239643706515052 6.88797352372973e-10 NA NA NA hsa-miR-708-3p TEAD1 2.80907765282502 3.07460722669281e-14 -1.49495998391161 1.96516757915294e-13 mirMAP -0.140207422764129 8.59517978921265e-08 NA NA NA hsa-miR-92a-3p TEAD1 2.06460102658973 1.44784291084757e-19 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.30018770980659 5.10954488255201e-13 NA NA NA hsa-miR-93-5p TEAD1 3.03961860136032 1.11672209617395e-24 -1.49495998391161 1.96516757915294e-13 mirMAP -0.288901564666728 6.54889052149517e-21 NA NA NA hsa-miR-96-5p TEAD1 4.89433085814374 1.92000659886961e-31 -1.49495998391161 1.96516757915294e-13 TargetScan;miRNATAP -0.193517137203882 1.62532200457822e-18 NA NA NA hsa-miR-98-5p TEAD1 1.11154309866014 1.24143909012085e-08 -1.49495998391161 1.96516757915294e-13 miRNAWalker2_validate -0.276225799254993 5.65409961838846e-08 NA NA NA hsa-miR-423-5p TEAD2 0.963563145758616 9.86109015204915e-07 -0.309981749953825 0.440349236270702 MirTarget -0.292722019454804 0.00292859084554094 NA NA NA hsa-let-7i-5p TEAD3 0.412877696970403 0.00622731051981756 -0.395078933945584 0.0285177055772656 miRNATAP -0.411533358821147 7.62851066553862e-13 NA NA NA hsa-miR-146b-5p TEAD3 1.75587235896724 1.15724631266659e-07 -0.395078933945584 0.0285177055772656 miRanda -0.211492357735085 2.76830958369049e-17 NA NA NA hsa-miR-339-5p TEAD3 2.68710938429893 3.03134080808154e-16 -0.395078933945584 0.0285177055772656 miRanda -0.104104262224292 4.28150660032567e-05 NA NA NA hsa-miR-374b-5p TEAD3 0.0654362503857184 0.722673188879465 -0.395078933945584 0.0285177055772656 miRNATAP -0.196902754002995 3.71448279366758e-05 NA NA NA hsa-miR-590-3p TEAD3 2.59289455139753 1.03200520972022e-21 -0.395078933945584 0.0285177055772656 miRNATAP -0.114718276129524 0.000262777322756625 NA NA NA hsa-miR-107 TEAD4 1.30977326593435 1.30372468603965e-11 1.00162629800195 0.00357453635342185 miRanda -0.226154284202831 0.00784737516970688 NA NA NA hsa-miR-98-5p TEAD4 1.11154309866014 1.24143909012085e-08 1.00162629800195 0.00357453635342185 miRNAWalker2_validate -0.568216818776135 7.6559487247626e-12 NA NA NA hsa-miR-744-5p TGFB1 1.48254348878737 3.23019501613577e-09 -0.000200257511168367 0.999409206375481 miRNAWalker2_validate;miRNATAP -0.229419410482444 6.9384219754003e-06 NA NA NA hsa-miR-107 TGFB2 1.30977326593435 1.30372468603965e-11 -1.19931727990522 0.00330886829654418 miRanda -0.51939474457829 1.98547903259176e-07 NA NA NA hsa-miR-126-5p TGFB2 0.895338176458417 2.33372756450713e-05 -1.19931727990522 0.00330886829654418 mirMAP -0.25743093726133 0.00599073764101041 NA NA NA hsa-miR-130b-3p TGFB2 3.5350292994509 1.73934183852569e-27 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.344962470893237 7.65363506175553e-10 NA NA NA hsa-miR-141-3p TGFB2 5.02396127982626 2.19224509139725e-24 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-148a-3p TGFB2 1.26728238710376 2.52325607402829e-06 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.286009485859132 8.40361643900754e-05 NA NA NA hsa-miR-148b-3p TGFB2 1.97815018171325 6.07715327281595e-26 -1.19931727990522 0.00330886829654418 MirTarget -0.76533615341931 3.3613707731401e-15 NA NA NA hsa-miR-149-5p TGFB2 2.94200492826326 4.93436498919036e-14 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.268302009449797 3.19540597089803e-08 NA NA NA hsa-miR-186-5p TGFB2 1.47445398888668 3.0781726595413e-15 -1.19931727990522 0.00330886829654418 mirMAP -0.621355169758057 1.07645506474653e-09 NA NA NA hsa-miR-200a-3p TGFB2 4.59434485520731 6.38952518573476e-18 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.349625252947739 2.44117272738656e-25 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 3.12352008343999 9.49391438647189e-07 -1.19931727990522 0.00330886829654418 MirTarget -0.137892151335788 5.76268091391752e-06 NA NA NA hsa-miR-29b-3p TGFB2 1.65828197923813 1.02676780888141e-09 -1.19931727990522 0.00330886829654418 miRTarBase;MirTarget;miRNATAP -0.231729413265765 0.0012231669483933 NA NA NA hsa-miR-29c-3p TGFB2 -0.00968972577705429 0.97099586346872 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.531424404132598 2.96641887384219e-13 NA NA NA hsa-miR-301a-3p TGFB2 2.81024345929638 2.29784847962242e-17 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.322704555190408 7.77034372961379e-08 NA NA NA hsa-miR-32-3p TGFB2 2.02436999565685 5.94091197945307e-09 -1.19931727990522 0.00330886829654418 mirMAP -0.27315114570865 1.69846948907938e-05 NA NA NA hsa-miR-320a TGFB2 0.438165828017084 0.0390159073347133 -1.19931727990522 0.00330886829654418 miRanda -0.39585907442477 2.33018021074793e-05 NA NA NA hsa-miR-320b TGFB2 1.55692969039548 1.41071034251915e-08 -1.19931727990522 0.00330886829654418 miRanda -0.298228917269413 2.53643349382992e-05 NA NA NA hsa-miR-324-5p TGFB2 2.95683728155095 1.32960514360912e-20 -1.19931727990522 0.00330886829654418 miRanda -0.302705023736643 2.71602770897574e-07 NA NA NA hsa-miR-330-3p TGFB2 0.876747334239085 0.00073709016089703 -1.19931727990522 0.00330886829654418 miRNATAP -0.457254743325048 1.06037579343258e-09 NA NA NA hsa-miR-330-5p TGFB2 1.15100069700871 4.85551805046014e-07 -1.19931727990522 0.00330886829654418 miRanda -0.360450971736555 2.54978879561545e-05 NA NA NA hsa-miR-331-5p TGFB2 2.17414714166315 1.54547681391888e-18 -1.19931727990522 0.00330886829654418 miRNATAP -0.239937976385475 0.00244538329219784 NA NA NA hsa-miR-335-3p TGFB2 3.08791651139852 5.31309869723517e-12 -1.19931727990522 0.00330886829654418 mirMAP -0.22185528629857 1.89547879442152e-07 NA NA NA hsa-miR-335-5p TGFB2 1.77247705492746 2.22457658872091e-06 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate -0.252111592909568 1.14412319370904e-06 NA NA NA hsa-miR-33a-3p TGFB2 1.72765312072219 1.51784443453521e-07 -1.19931727990522 0.00330886829654418 MirTarget;mirMAP -0.371056624502634 8.36332661191753e-09 NA NA NA hsa-miR-361-5p TGFB2 0.971859117235239 5.30236555707088e-09 -1.19931727990522 0.00330886829654418 miRNATAP -0.810004741713957 2.97484706931026e-12 NA NA NA hsa-miR-362-3p TGFB2 2.0756816987665 3.89026064579331e-12 -1.19931727990522 0.00330886829654418 miRanda -0.218398256631292 0.00107142313440827 NA NA NA hsa-miR-362-5p TGFB2 1.59303749908759 9.582675908797e-08 -1.19931727990522 0.00330886829654418 MirTarget -0.222085312260446 0.000683040393757458 NA NA NA hsa-miR-429 TGFB2 4.48815175680773 2.44117492218206e-17 -1.19931727990522 0.00330886829654418 miRNATAP -0.354478665199625 1.01610694076904e-25 NA NA NA hsa-miR-454-3p TGFB2 2.47234127820054 1.12878018736016e-21 -1.19931727990522 0.00330886829654418 MirTarget;miRNATAP -0.36249217687122 1.13442108861214e-06 NA NA NA hsa-miR-500a-5p TGFB2 1.72110365584658 3.0807246212659e-10 -1.19931727990522 0.00330886829654418 mirMAP -0.230492171637341 0.0012015489418391 NA NA NA hsa-miR-500b-5p TGFB2 1.72172606292185 3.06592098153205e-10 -1.19931727990522 0.00330886829654418 MirTarget -0.231076703558946 0.00116359223151538 NA NA NA hsa-miR-590-3p TGFB2 2.59289455139753 1.03200520972022e-21 -1.19931727990522 0.00330886829654418 mirMAP -0.266142801996328 0.000194961333085026 NA NA NA hsa-miR-590-5p TGFB2 3.18300989862077 2.06813568597893e-26 -1.19931727990522 0.00330886829654418 miRanda;miRNATAP -0.324271064441974 3.01832441227307e-07 NA NA NA hsa-miR-944 TGFB2 2.91186649218281 1.31574753528144e-06 -1.19931727990522 0.00330886829654418 mirMAP -0.180206577855112 5.25792273122866e-08 NA NA NA hsa-let-7a-3p TGFB3 1.42015538786275 7.03375209382654e-13 -1.92191802151593 4.13522948700016e-07 MirTarget -0.381916955776687 3.24138794334629e-05 NA NA NA hsa-miR-10a-5p TGFB3 1.15016989191194 0.00372037233992369 -1.92191802151593 4.13522948700016e-07 miRNAWalker2_validate -0.418366510356312 7.09740564892359e-21 NA NA NA hsa-miR-151a-5p TGFB3 2.32422038747303 2.66226949101065e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.825941146129225 4.42377138616228e-42 NA NA NA hsa-miR-26b-3p TGFB3 2.18464160365372 2.11543189388328e-18 -1.92191802151593 4.13522948700016e-07 MirTarget -0.677656521133706 2.42952260248002e-23 NA NA NA hsa-miR-29b-3p TGFB3 1.65828197923813 1.02676780888141e-09 -1.92191802151593 4.13522948700016e-07 miRTarBase -0.399950302957701 1.59835018316921e-09 NA NA NA hsa-miR-590-3p TGFB3 2.59289455139753 1.03200520972022e-21 -1.92191802151593 4.13522948700016e-07 miRanda -0.525346026949253 7.10585127062809e-16 NA NA NA hsa-miR-629-3p TGFB3 2.36570947321815 1.33458201201618e-11 -1.92191802151593 4.13522948700016e-07 MirTarget -0.297411694512799 3.147434114319e-07 NA NA NA hsa-let-7a-5p TGFBR1 0.618599506841644 2.76973453058748e-05 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.244428925468535 0.000440383623292106 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-let-7b-5p TGFBR1 0.604314269683977 0.00140009936153214 -0.531745632851025 0.0111481565689226 miRNATAP -0.164395211205111 0.002334077702266 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7d-5p TGFBR1 1.33236798905207 1.1741085658466e-13 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.249677273322744 5.91436156062502e-06 NA NA NA hsa-let-7e-5p TGFBR1 0.860104282510173 6.04758298373779e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.165779353656999 0.000445651685953496 NA NA NA hsa-let-7f-5p TGFBR1 0.495648727272215 0.00355972741198794 -0.531745632851025 0.0111481565689226 miRNATAP -0.212539435969951 0.000421071580866339 NA NA NA hsa-let-7g-5p TGFBR1 1.20061455355116 1.50237505511483e-12 -0.531745632851025 0.0111481565689226 miRNATAP -0.498242721643013 1.58222259474873e-18 NA NA NA hsa-miR-101-3p TGFBR1 0.522819989585461 0.00375627731618038 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.356084641759078 1.678272043475e-10 NA NA NA hsa-miR-126-5p TGFBR1 0.895338176458417 2.33372756450713e-05 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.153123735128566 0.00137633400200009 NA NA NA hsa-miR-128-3p TGFBR1 1.63756041666078 6.79626586407187e-14 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRTarBase -0.248098643403413 2.90608464652714e-08 NA NA NA hsa-miR-130b-3p TGFBR1 3.5350292994509 1.73934183852569e-27 -0.531745632851025 0.0111481565689226 miRNATAP -0.134668437053487 3.34039315804437e-06 NA NA NA hsa-miR-16-2-3p TGFBR1 2.31623086727196 4.29838149388188e-20 -0.531745632851025 0.0111481565689226 mirMAP -0.118014665876922 0.00216991899384218 NA NA NA hsa-miR-181c-5p TGFBR1 1.58587920618301 1.57506918816933e-10 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.16918051477343 2.32913877572708e-05 NA NA NA hsa-miR-186-5p TGFBR1 1.47445398888668 3.0781726595413e-15 -0.531745632851025 0.0111481565689226 mirMAP -0.261901522962087 6.15270096138054e-07 NA NA NA hsa-miR-200b-3p TGFBR1 3.78235093249346 3.18343003239465e-14 -0.531745632851025 0.0111481565689226 mirMAP -0.185163040320424 3.55754064059769e-23 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-2110 TGFBR1 1.16625590651194 6.4784195289885e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.203122265430452 3.02839928126399e-08 NA NA NA hsa-miR-301a-3p TGFBR1 2.81024345929638 2.29784847962242e-17 -0.531745632851025 0.0111481565689226 miRNATAP -0.188558650494062 6.94428278524489e-10 NA NA NA hsa-miR-32-3p TGFBR1 2.02436999565685 5.94091197945307e-09 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.116207615183923 0.000365699800115398 NA NA NA hsa-miR-3200-3p TGFBR1 2.70510522077868 1.90469509928484e-08 -0.531745632851025 0.0111481565689226 miRNATAP -0.120700105473579 2.69621919466987e-08 NA NA NA hsa-miR-320a TGFBR1 0.438165828017084 0.0390159073347133 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.326176915517583 4.1064210958607e-12 NA NA NA hsa-miR-320b TGFBR1 1.55692969039548 1.41071034251915e-08 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.191128801910238 1.11537638054288e-07 NA NA NA hsa-miR-330-3p TGFBR1 0.876747334239085 0.00073709016089703 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.231238826647919 1.69019842696319e-09 NA NA NA hsa-miR-331-3p TGFBR1 2.28379581858927 1.99663919173155e-18 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.227588969955072 5.92157067223612e-10 NA NA NA hsa-miR-361-5p TGFBR1 0.971859117235239 5.30236555707088e-09 -0.531745632851025 0.0111481565689226 miRanda;mirMAP;miRNATAP -0.327512599032841 4.9385335452745e-08 NA NA NA hsa-miR-374a-5p TGFBR1 0.484615721953736 0.0042981729815149 -0.531745632851025 0.0111481565689226 mirMAP -0.1725550403971 0.00437986725180039 NA NA NA hsa-miR-429 TGFBR1 4.48815175680773 2.44117492218206e-17 -0.531745632851025 0.0111481565689226 miRanda;miRNATAP -0.169764852224625 2.30995613689702e-22 NA NA NA hsa-miR-454-3p TGFBR1 2.47234127820054 1.12878018736016e-21 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.205677505304361 6.16209314820036e-08 NA NA NA hsa-miR-500a-5p TGFBR1 1.72110365584658 3.0807246212659e-10 -0.531745632851025 0.0111481565689226 mirMAP -0.111391945877042 0.0022402772038843 NA NA NA hsa-miR-576-5p TGFBR1 2.20467023993664 3.4053475193793e-19 -0.531745632851025 0.0111481565689226 mirMAP -0.201284779052 2.74992936654638e-07 NA NA NA hsa-miR-589-3p TGFBR1 2.51971841868825 2.39125940264107e-11 -0.531745632851025 0.0111481565689226 mirMAP -0.104859492543737 0.000438540974273448 NA NA NA hsa-miR-590-3p TGFBR1 2.59289455139753 1.03200520972022e-21 -0.531745632851025 0.0111481565689226 PITA;miRanda;mirMAP;miRNATAP -0.139228339501584 0.000139021577037225 NA NA NA hsa-miR-590-5p TGFBR1 3.18300989862077 2.06813568597893e-26 -0.531745632851025 0.0111481565689226 PITA;miRanda -0.158386241001983 1.04882834086946e-06 NA NA NA hsa-miR-664a-3p TGFBR1 0.634721925861133 0.00520070178640421 -0.531745632851025 0.0111481565689226 mirMAP -0.321621318973717 1.70943055444078e-13 NA NA NA hsa-miR-769-5p TGFBR1 1.82023760596845 9.6815886564134e-14 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.228524293799953 9.85398652877069e-09 NA NA NA hsa-miR-944 TGFBR1 2.91186649218281 1.31574753528144e-06 -0.531745632851025 0.0111481565689226 PITA;mirMAP -0.104949150832685 4.75355134217921e-10 NA NA NA hsa-miR-96-5p TGFBR1 4.89433085814374 1.92000659886961e-31 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.138876787398621 7.90055950171446e-10 NA NA NA hsa-miR-98-5p TGFBR1 1.11154309866014 1.24143909012085e-08 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate -0.401926180925558 8.43130029155261e-16 NA NA NA hsa-miR-106a-5p TGFBR2 2.48882002962836 1.99757727374521e-12 -1.5612933795263 2.09571393414153e-11 miRTarBase;miRNATAP -0.174237668172683 2.7024970040951e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.46782146831112 1.36171495805632e-23 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.446340567749987 1.4640429348369e-26 NA NA NA hsa-miR-107 TGFBR2 1.30977326593435 1.30372468603965e-11 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.33082940368913 1.15759545655126e-08 NA NA NA hsa-miR-130a-3p TGFBR2 2.02021855058359 1.26427102520415e-11 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.187222356261558 5.74404160623046e-07 NA NA NA hsa-miR-130b-3p TGFBR2 3.5350292994509 1.73934183852569e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.279678154840768 1.9762101701233e-18 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 3.2710598467455 9.93128340539455e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.302277707820119 6.79145607037112e-19 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 1.47445398888668 3.0781726595413e-15 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.383453901935314 9.23917606419292e-11 NA NA NA hsa-miR-18a-5p TGFBR2 3.78535678765353 3.72446596213886e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.25381972833671 2.41323249210829e-16 NA NA NA hsa-miR-19a-3p TGFBR2 3.42309334186656 3.02671914353412e-28 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.277232207383645 1.48488496649533e-16 NA NA NA hsa-miR-19b-3p TGFBR2 2.49529833021187 1.57028265846699e-23 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.351923320676886 1.03809079896527e-16 NA NA NA hsa-miR-20a-5p TGFBR2 3.15577933619191 4.19753346442454e-25 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29433840605417 1.11976352607645e-17 NA NA NA hsa-miR-20b-5p TGFBR2 2.07706563022469 1.10107236083433e-05 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.105991731825053 9.98951097559816e-06 NA NA NA hsa-miR-21-5p TGFBR2 2.73773305747971 1.38864982139576e-43 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1959869038848 0.000202473977886908 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-29b-2-5p TGFBR2 0.910668640983475 0.00666655585493488 -1.5612933795263 2.09571393414153e-11 mirMAP -0.106614907621936 0.00190433915326164 NA NA NA hsa-miR-301a-3p TGFBR2 2.81024345929638 2.29784847962242e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.303245579782603 4.36341401740489e-19 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320a TGFBR2 0.438165828017084 0.0390159073347133 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.147256255771787 0.0072521693939925 NA NA NA hsa-miR-320b TGFBR2 1.55692969039548 1.41071034251915e-08 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.259785049714809 1.72104577406335e-10 NA NA NA hsa-miR-335-3p TGFBR2 3.08791651139852 5.31309869723517e-12 -1.5612933795263 2.09571393414153e-11 mirMAP -0.116451466105744 2.86501897855708e-06 NA NA NA hsa-miR-335-5p TGFBR2 1.77247705492746 2.22457658872091e-06 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.108328975461909 0.000362366652132911 NA NA NA hsa-miR-33a-3p TGFBR2 1.72765312072219 1.51784443453521e-07 -1.5612933795263 2.09571393414153e-11 mirMAP -0.218324746449326 5.80693592871469e-09 NA NA NA hsa-miR-429 TGFBR2 4.48815175680773 2.44117492218206e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.182453703283022 7.13137317316041e-20 NA NA NA hsa-miR-454-3p TGFBR2 2.47234127820054 1.12878018736016e-21 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.334757039971147 2.96928366293251e-15 NA NA NA hsa-miR-501-3p TGFBR2 1.83132758513743 1.10971547702065e-10 -1.5612933795263 2.09571393414153e-11 TargetScan -0.239042838968307 1.06476001924321e-09 NA NA NA hsa-miR-508-3p TGFBR2 1.05493034310846 0.0393857095042515 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.119214194503115 1.55583026735658e-07 NA NA NA hsa-miR-590-3p TGFBR2 2.59289455139753 1.03200520972022e-21 -1.5612933795263 2.09571393414153e-11 miRanda -0.298641027773627 2.0141780556407e-13 NA NA NA hsa-miR-590-5p TGFBR2 3.18300989862077 2.06813568597893e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.294796030766598 2.66958610835318e-16 NA NA NA hsa-miR-9-5p TGFBR2 1.02304182473283 0.042901377604859 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.120425377888386 8.76751437160767e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 2.06460102658973 1.44784291084757e-19 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.402171657787311 8.61853387794715e-18 NA NA NA hsa-miR-93-5p TGFBR2 3.03961860136032 1.11672209617395e-24 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.345215781740609 4.92958365930485e-23 NA NA NA hsa-miR-22-5p TP53BP2 1.88011544159252 1.63978222572222e-16 -0.309101830292327 0.021156273492593 miRNATAP -0.120716477708744 9.84965920346479e-06 NA NA NA hsa-miR-148b-3p WNT10B 1.97815018171325 6.07715327281595e-26 -1.27203222851497 0.00216255711887601 MirTarget -0.335932330151756 0.000961494889825557 NA NA NA hsa-miR-320a WNT10B 0.438165828017084 0.0390159073347133 -1.27203222851497 0.00216255711887601 miRanda -0.308659404441888 0.00123166210670891 NA NA NA hsa-miR-98-5p WNT10B 1.11154309866014 1.24143909012085e-08 -1.27203222851497 0.00216255711887601 miRNAWalker2_validate -0.428471972853677 2.63884478727919e-05 NA NA NA hsa-miR-320a WNT11 0.438165828017084 0.0390159073347133 -0.821017630142777 0.174343340060726 miRanda -0.419932472809252 0.00246805866460523 NA NA NA hsa-miR-330-3p WNT11 0.876747334239085 0.00073709016089703 -0.821017630142777 0.174343340060726 miRNATAP -0.630031523186883 1.32892882444745e-08 NA NA NA hsa-miR-429 WNT11 4.48815175680773 2.44117492218206e-17 -0.821017630142777 0.174343340060726 miRNATAP -0.323236245003944 4.91620754160683e-10 NA NA NA hsa-miR-139-5p WNT2 -1.52606598644743 1.20474151350665e-08 1.46246443466742 0.00687918143780108 miRanda -0.271811172089886 0.00495601435504474 NA NA NA hsa-miR-324-5p WNT2 2.95683728155095 1.32960514360912e-20 1.46246443466742 0.00687918143780108 miRanda -0.38757678515523 6.86691469936031e-07 NA NA NA hsa-miR-532-5p WNT2 1.55697650978597 1.57884735535196e-11 1.46246443466742 0.00687918143780108 miRNATAP -0.448940114207323 5.28040850028776e-05 NA NA NA hsa-miR-590-3p WNT2 2.59289455139753 1.03200520972022e-21 1.46246443466742 0.00687918143780108 miRanda;mirMAP -0.329847894616273 0.000497680240546934 NA NA NA hsa-miR-624-5p WNT2 1.47043111118159 8.25080691741182e-09 1.46246443466742 0.00687918143780108 MirTarget -0.373112640327464 0.000392477231594863 NA NA NA hsa-miR-944 WNT2 2.91186649218281 1.31574753528144e-06 1.46246443466742 0.00687918143780108 mirMAP -0.175095840465174 7.5128597488646e-05 NA NA NA hsa-miR-130a-3p WNT2B 2.02021855058359 1.26427102520415e-11 -2.76786035438807 3.62604310321995e-16 MirTarget -0.173292145162377 0.00189834360154361 NA NA NA hsa-miR-130b-3p WNT2B 3.5350292994509 1.73934183852569e-27 -2.76786035438807 3.62604310321995e-16 MirTarget -0.303083727967098 3.15414419909699e-10 NA NA NA hsa-miR-186-5p WNT2B 1.47445398888668 3.0781726595413e-15 -2.76786035438807 3.62604310321995e-16 mirMAP -0.526224059963912 1.96983492918001e-09 NA NA NA hsa-miR-301a-3p WNT2B 2.81024345929638 2.29784847962242e-17 -2.76786035438807 3.62604310321995e-16 MirTarget -0.287791209206809 2.43082847555678e-08 NA NA NA hsa-miR-32-3p WNT2B 2.02436999565685 5.94091197945307e-09 -2.76786035438807 3.62604310321995e-16 mirMAP -0.251790961985528 3.87936769691564e-06 NA NA NA hsa-miR-429 WNT2B 4.48815175680773 2.44117492218206e-17 -2.76786035438807 3.62604310321995e-16 miRNATAP -0.169581846338325 2.5079526239863e-08 NA NA NA hsa-miR-454-3p WNT2B 2.47234127820054 1.12878018736016e-21 -2.76786035438807 3.62604310321995e-16 MirTarget -0.41394177732075 6.39547989328164e-11 NA NA NA hsa-miR-576-5p WNT2B 2.20467023993664 3.4053475193793e-19 -2.76786035438807 3.62604310321995e-16 mirMAP -0.435613826545259 2.2340672726842e-11 NA NA NA hsa-miR-1-3p WNT3 -3.48370702447685 1.98579484008516e-13 2.12870130495657 9.36625720886595e-10 MirTarget -0.151819324676344 1.34289419213407e-05 NA NA NA hsa-miR-185-5p WNT5B 2.34016206907488 1.17481626642022e-26 -2.10977851058083 2.85645296158293e-05 miRNAWalker2_validate -0.60642348108017 6.66154666586742e-09 NA NA NA hsa-miR-28-5p WNT5B 0.230152919654905 0.0742909586754846 -2.10977851058083 2.85645296158293e-05 miRanda -0.530836498754109 0.00709692972406734 NA NA NA hsa-miR-339-5p WNT5B 2.68710938429893 3.03134080808154e-16 -2.10977851058083 2.85645296158293e-05 miRanda -0.219739518248835 0.00231584366935923 NA NA NA hsa-miR-15b-5p WNT7A 1.57112623124278 9.14247846750597e-13 1.48380060438584 0.0764894326083681 MirTarget -0.548908791209485 0.00235306455612105 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-361-5p WNT7A 0.971859117235239 5.30236555707088e-09 1.48380060438584 0.0764894326083681 MirTarget;PITA;miRanda -0.781472713576135 0.00129094368654843 NA NA NA hsa-miR-1226-3p WNT9A 1.38118928579963 0.000205503474787488 -2.06944914631955 1.31351479409276e-06 mirMAP -0.23306118890322 0.000261269579227027 NA NA NA hsa-miR-140-3p WNT9A 0.0608890720479334 0.727716871248724 -2.06944914631955 1.31351479409276e-06 mirMAP -0.579602489890684 1.58809164562323e-06 NA NA NA hsa-miR-148a-3p WNT9A 1.26728238710376 2.52325607402829e-06 -2.06944914631955 1.31351479409276e-06 mirMAP -0.270568023187923 0.00044238677321366 NA NA NA hsa-miR-148b-3p WNT9A 1.97815018171325 6.07715327281595e-26 -2.06944914631955 1.31351479409276e-06 mirMAP -0.797484051103519 8.69028922154765e-15 NA NA NA hsa-miR-15a-5p WNT9A 2.34669284378787 1.69544424500258e-23 -2.06944914631955 1.31351479409276e-06 mirMAP -0.523049603269295 3.33612355484908e-10 NA NA NA hsa-miR-15b-5p WNT9A 1.57112623124278 9.14247846750597e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.537310487356042 4.9690416749748e-09 NA NA NA hsa-miR-16-5p WNT9A 1.75824877145857 1.68592440033108e-16 -2.06944914631955 1.31351479409276e-06 mirMAP -0.527507066701592 2.02103779015698e-08 NA NA NA hsa-miR-181a-2-3p WNT9A 2.19062681262366 3.81790102612782e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.289021136203285 1.68823014050936e-05 NA NA NA hsa-miR-185-3p WNT9A 2.3922478518806 1.3373426768452e-14 -2.06944914631955 1.31351479409276e-06 mirMAP -0.317845522149715 9.19525985946639e-07 NA NA NA hsa-miR-193a-3p WNT9A 1.60460546928078 2.86169793322984e-07 -2.06944914631955 1.31351479409276e-06 mirMAP -0.220704468389379 0.000836909244150302 NA NA NA hsa-miR-22-3p WNT9A 1.21545661147757 1.61670170137775e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.387232862036002 0.00200886957549209 NA NA NA hsa-miR-28-5p WNT9A 0.230152919654905 0.0742909586754846 -2.06944914631955 1.31351479409276e-06 mirMAP -0.499108130649814 0.00291674315897674 NA NA NA hsa-miR-32-5p WNT9A 2.34056473219422 6.24134585974322e-20 -2.06944914631955 1.31351479409276e-06 mirMAP -0.40706330365171 1.50628991198258e-07 NA NA NA hsa-miR-330-3p WNT9A 0.876747334239085 0.00073709016089703 -2.06944914631955 1.31351479409276e-06 mirMAP -0.253505316490192 0.0016392308187285 NA NA NA hsa-miR-331-3p WNT9A 2.28379581858927 1.99663919173155e-18 -2.06944914631955 1.31351479409276e-06 mirMAP -0.430796168913306 1.56673396070433e-08 NA NA NA hsa-miR-335-5p WNT9A 1.77247705492746 2.22457658872091e-06 -2.06944914631955 1.31351479409276e-06 miRNAWalker2_validate -0.215938135028036 8.72995417938918e-05 NA NA NA hsa-miR-363-3p WNT9A 1.50575300026701 0.00020976164678918 -2.06944914631955 1.31351479409276e-06 mirMAP -0.269097283647112 1.08413450909078e-07 NA NA NA hsa-miR-424-5p WNT9A 1.61930224569578 1.89642549274994e-10 -2.06944914631955 1.31351479409276e-06 mirMAP -0.335943130936018 3.02480044382518e-05 NA NA NA hsa-miR-532-3p WNT9A 1.96631878320218 4.53421954361695e-13 -2.06944914631955 1.31351479409276e-06 mirMAP -0.491322601879638 2.44328125497404e-11 NA NA NA hsa-miR-589-3p WNT9A 2.51971841868825 2.39125940264107e-11 -2.06944914631955 1.31351479409276e-06 mirMAP -0.320844220548304 1.47772350028815e-07 NA NA NA hsa-miR-708-5p WNT9A 3.38051631555486 5.12590198690777e-18 -2.06944914631955 1.31351479409276e-06 mirMAP -0.177570506962564 0.000533342150132389 NA NA NA hsa-miR-96-5p WNT9A 4.89433085814374 1.92000659886961e-31 -2.06944914631955 1.31351479409276e-06 mirMAP -0.222468024671624 2.30697971748039e-06 NA NA NA hsa-miR-106b-5p WTIP 2.46782146831112 1.36171495805632e-23 -0.143470050488438 0.575976441100554 mirMAP -0.160820829930014 0.000732924226121533 NA NA NA hsa-miR-15b-5p WTIP 1.57112623124278 9.14247846750597e-13 -0.143470050488438 0.575976441100554 mirMAP -0.199814792571391 0.000278736584044146 NA NA NA hsa-miR-16-5p WTIP 1.75824877145857 1.68592440033108e-16 -0.143470050488438 0.575976441100554 mirMAP -0.151073383481815 0.00736966234836284 NA NA NA hsa-miR-183-5p WTIP 4.19757025992371 4.79612296318304e-26 -0.143470050488438 0.575976441100554 mirMAP -0.113590583310167 9.5393014870332e-05 NA NA NA hsa-miR-324-3p WTIP 2.08739139768981 3.11885987067952e-13 -0.143470050488438 0.575976441100554 mirMAP -0.117337406011116 0.00532956135788095 NA NA NA hsa-miR-331-3p WTIP 2.28379581858927 1.99663919173155e-18 -0.143470050488438 0.575976441100554 mirMAP -0.16569343892146 0.000273821128182358 NA NA NA hsa-miR-3615 WTIP 2.22631608637736 1.11307777062266e-16 -0.143470050488438 0.575976441100554 mirMAP -0.14763341633971 0.00124096177666831 NA NA NA hsa-miR-425-5p WTIP 3.07071373939774 4.02947460586085e-25 -0.143470050488438 0.575976441100554 mirMAP -0.114464172801879 0.00365953834826764 NA NA NA hsa-miR-484 WTIP 1.81844463411787 1.82951571230938e-15 -0.143470050488438 0.575976441100554 mirMAP -0.162628396375071 0.00198077491746807 NA NA NA hsa-miR-582-3p WTIP 0.00876844181512659 0.977126166214707 -0.143470050488438 0.575976441100554 mirMAP -0.143074989088109 0.000415286222232087 NA NA NA hsa-miR-769-3p WTIP 2.19896922202687 5.69250370895053e-12 -0.143470050488438 0.575976441100554 mirMAP -0.103142877686927 0.00824970314018707 NA NA NA hsa-miR-1-3p WWC1 -3.48370702447685 1.98579484008516e-13 2.53265987846443 6.00203795074494e-16 MirTarget -0.152985109643808 1.52891483670956e-06 NA NA NA hsa-miR-10b-3p WWTR1 0.77597971642517 0.00264877454133753 -1.56733544291317 4.73134165029796e-08 MirTarget -0.292054405652968 6.29334628075521e-08 NA NA NA hsa-miR-126-5p WWTR1 0.895338176458417 2.33372756450713e-05 -1.56733544291317 4.73134165029796e-08 mirMAP -0.210562190418713 0.00155271644091129 NA NA NA hsa-miR-130b-5p WWTR1 2.9963110846538 1.98883029416455e-18 -1.56733544291317 4.73134165029796e-08 MirTarget;miRNATAP -0.307532244479195 5.54163090464981e-15 NA NA NA hsa-miR-141-3p WWTR1 5.02396127982626 2.19224509139725e-24 -1.56733544291317 4.73134165029796e-08 MirTarget;TargetScan;miRNATAP -0.305882494344842 5.69456849157899e-35 NA NA NA hsa-miR-149-5p WWTR1 2.94200492826326 4.93436498919036e-14 -1.56733544291317 4.73134165029796e-08 miRNATAP -0.235018899913672 6.12396780965545e-12 NA NA NA hsa-miR-17-3p WWTR1 2.2704817679209 1.1667437320211e-22 -1.56733544291317 4.73134165029796e-08 MirTarget -0.372022764510375 5.87633033597013e-11 NA NA NA hsa-miR-181a-2-3p WWTR1 2.19062681262366 3.81790102612782e-13 -1.56733544291317 4.73134165029796e-08 MirTarget -0.248867662835361 2.95202501472249e-08 NA NA NA hsa-miR-18a-5p WWTR1 3.78535678765353 3.72446596213886e-26 -1.56733544291317 4.73134165029796e-08 miRNAWalker2_validate -0.208373458895069 7.03126899059127e-08 NA NA NA hsa-miR-1976 WWTR1 2.06550563678192 7.81396978619772e-18 -1.56733544291317 4.73134165029796e-08 MirTarget -0.361732716914741 7.2645097069192e-11 NA NA NA hsa-miR-200a-3p WWTR1 4.59434485520731 6.38952518573476e-18 -1.56733544291317 4.73134165029796e-08 MirTarget;miRNATAP -0.295919437207055 2.68344241203465e-37 NA NA NA hsa-miR-205-5p WWTR1 4.1389800495524 2.05488295686453e-12 -1.56733544291317 4.73134165029796e-08 miRNATAP -0.148412613236665 7.32079666588013e-11 NA NA NA hsa-miR-29b-3p WWTR1 1.65828197923813 1.02676780888141e-09 -1.56733544291317 4.73134165029796e-08 miRNATAP -0.329678672912402 4.30338780989915e-11 NA NA NA hsa-miR-29c-3p WWTR1 -0.00968972577705429 0.97099586346872 -1.56733544291317 4.73134165029796e-08 miRNATAP -0.391374405705574 3.69345450194356e-14 NA NA NA hsa-miR-3065-5p WWTR1 2.74629919868982 1.86846589298284e-08 -1.56733544291317 4.73134165029796e-08 mirMAP -0.101937552522017 0.00337167033142904 NA NA NA hsa-miR-30b-5p WWTR1 0.800822374912712 0.000133601914525413 -1.56733544291317 4.73134165029796e-08 MirTarget;mirMAP -0.479711155685502 2.67936620017086e-13 NA NA NA hsa-miR-30c-5p WWTR1 0.778774633108 0.000285599212429136 -1.56733544291317 4.73134165029796e-08 MirTarget;mirMAP -0.585896034973273 1.20777745948835e-20 NA NA NA hsa-miR-30d-5p WWTR1 0.675423997639582 0.00270618816039773 -1.56733544291317 4.73134165029796e-08 MirTarget;mirMAP -0.52537249857749 3.41781518291613e-18 NA NA NA hsa-miR-30e-5p WWTR1 1.23904909539663 1.35561917122157e-09 -1.56733544291317 4.73134165029796e-08 MirTarget -0.739771929967758 1.86042049449707e-31 NA NA NA hsa-miR-32-3p WWTR1 2.02436999565685 5.94091197945307e-09 -1.56733544291317 4.73134165029796e-08 mirMAP -0.187158358967197 3.4786160869449e-05 NA NA NA hsa-miR-320a WWTR1 0.438165828017084 0.0390159073347133 -1.56733544291317 4.73134165029796e-08 miRanda;miRNATAP -0.451245300520119 5.26413797801058e-12 NA NA NA hsa-miR-320b WWTR1 1.55692969039548 1.41071034251915e-08 -1.56733544291317 4.73134165029796e-08 miRanda;miRNATAP -0.319607087520147 1.24783055768352e-10 NA NA NA hsa-miR-335-3p WWTR1 3.08791651139852 5.31309869723517e-12 -1.56733544291317 4.73134165029796e-08 MirTarget -0.201890012350434 1.63445858572652e-11 NA NA NA hsa-miR-335-5p WWTR1 1.77247705492746 2.22457658872091e-06 -1.56733544291317 4.73134165029796e-08 miRNAWalker2_validate -0.226266542089514 5.97941101150976e-10 NA NA NA hsa-miR-3607-3p WWTR1 2.68532138541128 5.66716351955047e-14 -1.56733544291317 4.73134165029796e-08 mirMAP -0.292611835624803 1.74609720628361e-14 NA NA NA hsa-miR-374a-5p WWTR1 0.484615721953736 0.0042981729815149 -1.56733544291317 4.73134165029796e-08 MirTarget;mirMAP -0.263983999274887 0.00169468086341875 NA NA NA hsa-miR-3913-5p WWTR1 2.44353493655328 8.95279496632448e-15 -1.56733544291317 4.73134165029796e-08 mirMAP -0.410634415401048 4.12001158974522e-22 NA NA NA hsa-miR-501-5p WWTR1 1.93654809410041 1.3779381780759e-10 -1.56733544291317 4.73134165029796e-08 mirMAP -0.282466897647835 1.11572738594555e-09 NA NA NA hsa-miR-576-5p WWTR1 2.20467023993664 3.4053475193793e-19 -1.56733544291317 4.73134165029796e-08 MirTarget;mirMAP -0.385508629608298 6.6418769435725e-13 NA NA NA hsa-miR-582-3p WWTR1 0.00876844181512659 0.977126166214707 -1.56733544291317 4.73134165029796e-08 miRNATAP -0.135996825648389 0.00327944469255315 NA NA NA hsa-miR-582-5p WWTR1 0.609226359812689 0.032988717891497 -1.56733544291317 4.73134165029796e-08 MirTarget;PITA -0.195320749276883 7.22046028428692e-05 NA NA NA hsa-miR-590-3p WWTR1 2.59289455139753 1.03200520972022e-21 -1.56733544291317 4.73134165029796e-08 MirTarget;miRanda;mirMAP -0.312019307208413 4.65252234244266e-10 NA NA NA hsa-miR-651-5p WWTR1 2.32951837918862 1.62508965949028e-11 -1.56733544291317 4.73134165029796e-08 MirTarget -0.32002836387098 2.25364680239739e-13 NA NA NA hsa-miR-664a-3p WWTR1 0.634721925861133 0.00520070178640421 -1.56733544291317 4.73134165029796e-08 MirTarget;mirMAP -0.592440467417079 1.13562204419094e-23 NA NA NA hsa-miR-7-1-3p WWTR1 1.84950311431067 1.25300363397654e-13 -1.56733544291317 4.73134165029796e-08 mirMAP -0.298330465983706 4.07645835742348e-08 NA NA NA hsa-miR-93-3p WWTR1 2.85383869771942 5.64481766902125e-23 -1.56733544291317 4.73134165029796e-08 MirTarget -0.441435990799222 7.59439833262045e-24 NA NA NA hsa-miR-944 WWTR1 2.91186649218281 1.31574753528144e-06 -1.56733544291317 4.73134165029796e-08 MirTarget -0.124426381713483 1.31300279809624e-07 NA NA NA hsa-let-7a-3p YAP1 1.42015538786275 7.03375209382654e-13 -0.819514922156015 7.72909626929227e-05 mirMAP -0.143868237421206 0.00407737267220801 NA NA NA hsa-miR-126-5p YAP1 0.895338176458417 2.33372756450713e-05 -0.819514922156015 7.72909626929227e-05 mirMAP;miRNATAP -0.20913255045659 1.00448955629125e-05 NA NA NA hsa-miR-141-3p YAP1 5.02396127982626 2.19224509139725e-24 -0.819514922156015 7.72909626929227e-05 MirTarget;TargetScan -0.107645543722487 1.48207382564769e-08 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-141-5p YAP1 3.81419396518882 3.21977359736126e-18 -0.819514922156015 7.72909626929227e-05 miRNATAP -0.115091863383006 1.2801433096082e-07 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-16-2-3p YAP1 2.31623086727196 4.29838149388188e-20 -0.819514922156015 7.72909626929227e-05 mirMAP -0.212953175833193 1.75956128484433e-08 NA NA NA hsa-miR-186-5p YAP1 1.47445398888668 3.0781726595413e-15 -0.819514922156015 7.72909626929227e-05 MirTarget -0.306395992237321 3.69330739143338e-09 27073580 We observed that miR-186 was downregulated in several HCC cell lines and that it directly targets YAP1 mRNA; Overexpression of miR-186 in HCC cells significantly downregulates YAP1 mRNA and protein levels leading to downregulation of the Hippo signaling pathway which in turn severely inhibits HCC cell migration invasion and proliferation; Our study is the first to report the direct involvement of miR-186 in downregulating YAP1 and more significantly inhibiting HCC tumorigenesis and supports the role miR-186 as a potential therapeutic target in treating liver cancer cell migration;tumorigenesis liver cancer hsa-miR-200a-3p YAP1 4.59434485520731 6.38952518573476e-18 -0.819514922156015 7.72909626929227e-05 miRNAWalker2_validate;MirTarget -0.116465428459349 5.57675633205442e-11 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 3.78235093249346 3.18343003239465e-14 -0.819514922156015 7.72909626929227e-05 MirTarget -0.118880302646558 6.39640575477105e-10 NA NA NA hsa-miR-200c-3p YAP1 3.50132673580082 2.42716349086937e-15 -0.819514922156015 7.72909626929227e-05 MirTarget -0.104660951992012 1.60861074970143e-06 NA NA NA hsa-miR-26b-5p YAP1 0.885393662798425 3.2116297961629e-06 -0.819514922156015 7.72909626929227e-05 miRNAWalker2_validate -0.155271718784889 0.00345804443527015 NA NA NA hsa-miR-33a-3p YAP1 1.72765312072219 1.51784443453521e-07 -0.819514922156015 7.72909626929227e-05 mirMAP -0.1107445163667 0.000857537362043255 NA NA NA hsa-miR-34a-3p YAP1 1.75590866103657 8.02801510630657e-09 -0.819514922156015 7.72909626929227e-05 MirTarget -0.169740717437944 2.39565677986146e-06 NA NA NA hsa-miR-3607-3p YAP1 2.68532138541128 5.66716351955047e-14 -0.819514922156015 7.72909626929227e-05 mirMAP -0.135640017297819 1.14136526377216e-06 NA NA NA hsa-miR-361-3p YAP1 1.07367425434318 1.73142774168958e-09 -0.819514922156015 7.72909626929227e-05 MirTarget;PITA -0.240529277550041 1.70458312134651e-05 NA NA NA hsa-miR-361-5p YAP1 0.971859117235239 5.30236555707088e-09 -0.819514922156015 7.72909626929227e-05 miRanda -0.256453011333039 2.01754713090572e-05 NA NA NA hsa-miR-429 YAP1 4.48815175680773 2.44117492218206e-17 -0.819514922156015 7.72909626929227e-05 MirTarget;miRanda -0.11214625614141 3.9822420324722e-10 NA NA NA hsa-miR-484 YAP1 1.81844463411787 1.82951571230938e-15 -0.819514922156015 7.72909626929227e-05 PITA;miRNATAP -0.291798035788354 3.23193028417414e-12 NA NA NA hsa-miR-532-5p YAP1 1.55697650978597 1.57884735535196e-11 -0.819514922156015 7.72909626929227e-05 PITA -0.239099203138597 1.57096350266101e-08 NA NA NA hsa-miR-590-3p YAP1 2.59289455139753 1.03200520972022e-21 -0.819514922156015 7.72909626929227e-05 miRanda;mirMAP -0.208488993365565 6.67164473499825e-09 NA NA NA hsa-miR-590-5p YAP1 3.18300989862077 2.06813568597893e-26 -0.819514922156015 7.72909626929227e-05 MirTarget;PITA;miRanda;miRNATAP -0.199962139523476 4.08485968085029e-10 NA NA NA hsa-miR-625-5p YAP1 1.42540152147292 1.95797147911206e-06 -0.819514922156015 7.72909626929227e-05 MirTarget -0.147228805903683 5.46156978788901e-05 NA NA NA hsa-miR-7-1-3p YAP1 1.84950311431067 1.25300363397654e-13 -0.819514922156015 7.72909626929227e-05 mirMAP -0.272069114118056 1.50581196058606e-12 NA NA NA hsa-miR-708-3p YAP1 2.80907765282502 3.07460722669281e-14 -0.819514922156015 7.72909626929227e-05 mirMAP -0.131062526086185 5.45073036860843e-07 NA NA NA hsa-miR-26a-5p YWHAE 0.0464832722967259 0.752628386912329 0.514491612368612 0.000180862815548893 miRNAWalker2_validate;miRNATAP -0.174289033994773 0.000159844329938043 NA NA NA hsa-miR-181c-5p YWHAG 1.58587920618301 1.57506918816933e-10 0.156220759818473 0.240477359976782 MirTarget;miRNATAP -0.107876701640243 1.92571385553603e-05 NA NA NA hsa-miR-23b-3p YWHAG -0.251132426825047 0.150200321210792 0.156220759818473 0.240477359976782 MirTarget;miRNATAP -0.117341634709916 0.00162529518912031 NA NA NA hsa-miR-30b-5p YWHAG 0.800822374912712 0.000133601914525413 0.156220759818473 0.240477359976782 miRNATAP -0.132163142680483 1.39361681058969e-05 NA NA NA hsa-miR-30c-5p YWHAG 0.778774633108 0.000285599212429136 0.156220759818473 0.240477359976782 miRNATAP -0.154812531241318 1.64179950979699e-07 NA NA NA hsa-miR-30d-5p YWHAG 0.675423997639582 0.00270618816039773 0.156220759818473 0.240477359976782 miRNATAP -0.132575862878577 2.82953377535704e-06 NA NA NA hsa-miR-30e-5p YWHAG 1.23904909539663 1.35561917122157e-09 0.156220759818473 0.240477359976782 miRNATAP -0.121468680568388 8.32409315658241e-05 NA NA NA hsa-miR-320a YWHAG 0.438165828017084 0.0390159073347133 0.156220759818473 0.240477359976782 PITA;miRanda;miRNATAP -0.100995313053263 0.000877783562361283 NA NA NA hsa-miR-103a-3p YWHAH 1.44083190496858 1.53799939616416e-13 -0.039384739798634 0.787929142314944 miRNAWalker2_validate;MirTarget;miRNATAP -0.161531751525804 4.29697423677565e-06 NA NA NA hsa-miR-107 YWHAH 1.30977326593435 1.30372468603965e-11 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRanda;miRNATAP -0.102725815874759 0.0042174879223718 NA NA NA hsa-miR-28-5p YWHAH 0.230152919654905 0.0742909586754846 -0.039384739798634 0.787929142314944 PITA;miRanda -0.2331357688511 3.2675565751886e-05 NA NA NA hsa-miR-320a YWHAH 0.438165828017084 0.0390159073347133 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRanda -0.222237517506915 1.10194526758971e-11 NA NA NA hsa-miR-330-3p YWHAH 0.876747334239085 0.00073709016089703 -0.039384739798634 0.787929142314944 MirTarget;PITA;miRNATAP -0.16424153759537 6.98871148996655e-10 NA NA NA hsa-miR-361-5p YWHAH 0.971859117235239 5.30236555707088e-09 -0.039384739798634 0.787929142314944 miRanda -0.219428557867208 1.49722216074945e-07 NA NA NA hsa-miR-320a YWHAQ 0.438165828017084 0.0390159073347133 0.144077300408211 0.350876471829226 MirTarget;PITA;miRanda;miRNATAP -0.167079673898302 1.83255873389778e-06 NA NA NA hsa-miR-664a-3p YWHAZ 0.634721925861133 0.00520070178640421 0.309265826104513 0.0711240023820104 mirMAP -0.133473662727781 0.000250895262565301 NA NA NA