miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p APC -0.297128724729339 0.869294443540749 0.196794568986726 0.852946173267447 miRNAWalker2_validate;miRTarBase -0.221090416247696 2.74224832837052e-06 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-148a-3p APC -0.101286586375016 0.976980454193186 0.196794568986726 0.852946173267447 miRNAWalker2_validate -0.11689005190455 0.00640789868321619 NA NA NA hsa-miR-154-3p APC -0.170366170038505 0.546500133020447 0.196794568986726 0.852946173267447 TargetScan -0.11742585355327 0.00356137566396406 NA NA NA hsa-miR-192-5p APC -0.117345487848223 0.972927287653137 0.196794568986726 0.852946173267447 miRNAWalker2_validate -0.113719244280745 0.000540682729973804 NA NA NA hsa-miR-193a-3p APC -0.247265785363732 0.654363581941634 0.196794568986726 0.852946173267447 miRanda -0.150390924294565 0.000107999447451728 NA NA NA hsa-miR-27a-3p APC -0.123902317731458 0.958804393510999 0.196794568986726 0.852946173267447 miRNAWalker2_validate;miRTarBase;miRNATAP -0.172640999838069 0.00983801888943467 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-335-3p APC -0.244830745789445 0.88450019116631 0.196794568986726 0.852946173267447 mirMAP -0.214685562769503 6.31038682998398e-09 NA NA NA hsa-miR-374a-5p APC -0.343007247142618 0.766921280269271 0.196794568986726 0.852946173267447 mirMAP -0.283252682346721 1.3727422438847e-06 NA NA NA hsa-miR-374b-5p APC -0.285682091626878 0.83569830479965 0.196794568986726 0.852946173267447 mirMAP -0.202348624592442 0.000440637961909132 NA NA NA hsa-miR-421 APC -0.182032017078616 0.734704500318599 0.196794568986726 0.852946173267447 miRanda -0.147549411526102 0.00019991634323926 NA NA NA hsa-miR-450b-5p APC -0.0136687538973108 0.983149761399849 0.196794568986726 0.852946173267447 miRNATAP -0.17244181378059 6.24983424543036e-05 NA NA NA hsa-miR-501-3p APC -0.753812576327832 0.552763280802254 0.196794568986726 0.852946173267447 TargetScan -0.120932259670203 0.00171395840019733 NA NA NA hsa-miR-590-3p APC -0.279244755376859 0.59126669933662 0.196794568986726 0.852946173267447 PITA;miRanda;mirMAP;miRNATAP -0.10191760855962 0.00339239832008087 NA NA NA hsa-miR-20a-3p APC2 0.456808229166028 0.57674056136504 -0.381720873846146 0.363749276154213 mirMAP -0.165842843423182 0.0095606046251902 NA NA NA hsa-miR-452-3p APC2 -0.167134177977311 0.799008246175244 -0.381720873846146 0.363749276154213 mirMAP -0.168552343103693 0.00952847701626536 NA NA NA hsa-miR-582-5p AXIN2 -0.399450205475138 0.581227478860085 0.161547979876199 0.922492848211098 miRNATAP -0.53581634834622 2.73561419818281e-06 NA NA NA hsa-miR-195-3p CACYBP 0.122473158217745 0.691917127032363 0.0435559673396799 0.976925582631481 mirMAP -0.151794176709915 2.24952439329053e-07 NA NA NA hsa-miR-30a-3p CACYBP 0.250338313897394 0.917094926793447 0.0435559673396799 0.976925582631481 MirTarget -0.232333100711769 6.31345446632718e-08 NA NA NA hsa-miR-186-5p CAMK2B -0.318786974828757 0.85412722938961 2.17047179638848 0.00981662259739031 miRNAWalker2_validate;miRNATAP -0.920452799641873 5.35166959877138e-07 NA NA NA hsa-miR-18a-5p CAMK2B -0.498318455303917 0.61264091975585 2.17047179638848 0.00981662259739031 mirMAP -0.32652680243123 0.000780906706071633 NA NA NA hsa-miR-362-3p CAMK2B -0.721040238345347 0.0345881362485733 2.17047179638848 0.00981662259739031 miRanda -0.393573663761851 0.000260046149132286 NA NA NA hsa-miR-362-5p CAMK2B -0.26647467080141 0.752024885130738 2.17047179638848 0.00981662259739031 miRNATAP -0.425054831724973 3.04925288722957e-05 NA NA NA hsa-miR-577 CAMK2B -1.06238199218774 0.326056761787754 2.17047179638848 0.00981662259739031 miRNATAP -0.327780232625455 1.48895659141036e-06 NA NA NA hsa-miR-589-3p CAMK2B -0.835836305204965 0.0112001563801511 2.17047179638848 0.00981662259739031 MirTarget -0.471242264042232 3.88780893572071e-06 NA NA NA hsa-miR-590-3p CAMK2B -0.279244755376859 0.59126669933662 2.17047179638848 0.00981662259739031 miRanda -0.417111526860007 0.000159240762694534 NA NA NA hsa-miR-625-5p CAMK2B -0.690759472145277 0.210306534567564 2.17047179638848 0.00981662259739031 mirMAP -0.402774713768327 3.17411959747693e-05 NA NA NA hsa-miR-628-5p CAMK2B -0.508907702070671 0.351926682319915 2.17047179638848 0.00981662259739031 miRNATAP -0.530677211997499 0.00189248229560732 NA NA NA hsa-miR-940 CAMK2B -0.225788347550697 0.680055767105815 2.17047179638848 0.00981662259739031 PITA;miRNATAP -0.248002412691839 0.00939897429891113 NA NA NA hsa-miR-708-3p CAMK2D 0.137785606206693 0.896980471394499 -0.328303276365629 0.804663028569463 mirMAP -0.141079013249096 0.000231245836337699 NA NA NA hsa-miR-181a-5p CAMK2G 0.0295101956318291 0.989325168350125 0.214566145549961 0.868392768639694 miRNATAP -0.102688844978283 0.00194951276730845 NA NA NA hsa-miR-181b-5p CAMK2G 0.155313039554487 0.930176779696506 0.214566145549961 0.868392768639694 miRNATAP -0.100956135947566 0.00173481793066032 NA NA NA hsa-miR-628-5p CAMK2G -0.508907702070671 0.351926682319915 0.214566145549961 0.868392768639694 MirTarget;PITA;miRNATAP -0.167006149558629 1.34694775689948e-06 NA NA NA hsa-miR-16-5p CCND1 0.0135949734723564 0.994476223855607 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131352085119981 0.00823300401924536 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-195-5p CCND1 0.343201952346823 0.749622318650888 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135964440478054 0.00272099018653157 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-29c-3p CCND1 0.162451700202704 0.942720457512509 -0.254128537418143 0.890666103231997 mirMAP -0.140688238276882 0.00181263740987372 NA NA NA hsa-miR-24-3p CHD8 -0.0484778924256624 0.985274054814493 -0.225763687675904 0.872067570290545 miRNAWalker2_validate -0.171709221547382 0.00182902940441724 NA NA NA hsa-miR-493-5p CREBBP 0.229930075372342 0.731979520100109 -0.0709718431637629 0.963143997108611 miRNATAP -0.131589658655616 0.000363570308901921 NA NA NA hsa-miR-30e-5p CSNK1A1 -0.0657075181381011 0.979684509181941 0.0425031292154427 0.981068216393415 MirTarget -0.110082716517243 0.00277452335093186 NA NA NA hsa-miR-146b-5p CSNK2A2 -0.402662509440887 0.837510937985091 0.0524660037558826 0.962117099008393 miRanda -0.169704038600773 3.42562008282362e-06 NA NA NA hsa-miR-212-3p CSNK2A2 -0.0224067199236484 0.973232008101458 0.0524660037558826 0.962117099008393 mirMAP -0.11553803543894 0.00415916216062692 NA NA NA hsa-miR-92b-3p CSNK2A2 -0.569866984318692 0.689321861489779 0.0524660037558826 0.962117099008393 mirMAP -0.107283711109916 0.000581971462246387 NA NA NA hsa-miR-140-5p CTNNB1 -0.229213026275906 0.847330111738616 -0.27160111865579 0.897380291117619 miRanda -0.136902680392965 0.00185084671259549 NA NA NA hsa-let-7f-1-3p CXXC4 -0.31101436822914 0.693407210545374 0.790601166401651 0.212175078787021 mirMAP -0.519409376894187 0.00404440222223057 NA NA NA hsa-miR-126-5p CXXC4 0.0815213541035824 0.956637332055185 0.790601166401651 0.212175078787021 MirTarget;mirMAP -0.430475686374969 0.00512692539803872 NA NA NA hsa-miR-146b-5p CXXC4 -0.402662509440887 0.837510937985091 0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.659604627831056 7.80534193328136e-07 NA NA NA hsa-miR-223-3p CXXC4 -0.449245565106316 0.80968342565561 0.790601166401651 0.212175078787021 MirTarget -0.325866664946908 9.07866389122905e-05 NA NA NA hsa-miR-338-5p CXXC4 0.484769112400393 0.393961930708873 0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.296863316569803 0.000581851346394819 NA NA NA hsa-miR-576-5p CXXC4 -0.506413219377403 0.417187951364173 0.790601166401651 0.212175078787021 mirMAP -0.315679038651768 0.00846447050193405 NA NA NA hsa-miR-582-5p CXXC4 -0.399450205475138 0.581227478860085 0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.402689420215908 0.00183306402952214 NA NA NA hsa-miR-589-5p CXXC4 -0.448771545046784 0.722725226273464 0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.627876279687671 0.000117797435675094 NA NA NA hsa-miR-7-1-3p CXXC4 -0.462485777435991 0.665899751398166 0.790601166401651 0.212175078787021 mirMAP -0.359423110175008 0.00207272012054492 NA NA NA hsa-let-7a-3p DAAM1 -0.215598045625677 0.85543299203799 -0.170483432113034 0.857808092963577 MirTarget -0.142707913982381 0.00395938869466693 NA NA NA hsa-let-7g-3p DAAM1 -0.489638373791485 0.62941522205833 -0.170483432113034 0.857808092963577 MirTarget -0.122037825708611 0.00135747950994262 NA NA NA hsa-miR-125a-5p DAAM1 -0.00183986061615382 0.999158100170883 -0.170483432113034 0.857808092963577 MirTarget -0.154338230036723 0.00827558815103646 NA NA NA hsa-miR-130a-3p DAAM1 0.0910074087716906 0.929098200371948 -0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.186265972428335 4.80011426505858e-05 NA NA NA hsa-miR-130b-3p DAAM1 -0.221667315324818 0.824660172394714 -0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.190279619758573 3.00597553974218e-05 NA NA NA hsa-miR-130b-5p DAAM1 -0.6472141103776 0.379096015222509 -0.170483432113034 0.857808092963577 MirTarget -0.132266134140273 0.00224823100522212 NA NA NA hsa-miR-140-5p DAAM1 -0.229213026275906 0.847330111738616 -0.170483432113034 0.857808092963577 miRanda -0.202428791701825 0.00199244559179905 NA NA NA hsa-miR-142-3p DAAM1 -0.154235241441331 0.946098054588918 -0.170483432113034 0.857808092963577 miRanda -0.114139641450987 0.0017699000081446 NA NA NA hsa-miR-186-5p DAAM1 -0.318786974828757 0.85412722938961 -0.170483432113034 0.857808092963577 MirTarget;mirMAP -0.199851629594151 0.00143154535869659 NA NA NA hsa-miR-19a-3p DAAM1 -0.206793507801887 0.844637784802316 -0.170483432113034 0.857808092963577 miRNATAP -0.158631869740284 1.6104583445785e-05 NA NA NA hsa-miR-19b-3p DAAM1 -0.0268530183621474 0.986656783046572 -0.170483432113034 0.857808092963577 miRNATAP -0.219557475883144 4.94631687431852e-07 NA NA NA hsa-miR-27a-3p DAAM1 -0.123902317731458 0.958804393510999 -0.170483432113034 0.857808092963577 miRNATAP -0.323406617974826 4.61721444206115e-06 NA NA NA hsa-miR-29a-3p DAAM1 0.01127474410284 0.996977020481272 -0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.305904615233183 1.00784743884738e-07 NA NA NA hsa-miR-29b-3p DAAM1 -0.104016192263954 0.958988036765397 -0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.210603350286755 1.48679676188051e-06 NA NA NA hsa-miR-32-3p DAAM1 -0.568003960723004 0.13133163420273 -0.170483432113034 0.857808092963577 mirMAP -0.123812750565078 0.000115356287668564 NA NA NA hsa-miR-32-5p DAAM1 -0.05993267619119 0.952975951594959 -0.170483432113034 0.857808092963577 miRNATAP -0.139972847601259 0.0013313637746724 NA NA NA hsa-miR-335-5p DAAM1 -0.0284895175847679 0.973380867832231 -0.170483432113034 0.857808092963577 miRNAWalker2_validate;MirTarget;miRNATAP -0.158806516504925 9.35552512380998e-05 NA NA NA hsa-miR-362-3p DAAM1 -0.721040238345347 0.0345881362485733 -0.170483432113034 0.857808092963577 MirTarget;miRanda;miRNATAP -0.163521459566825 5.15503696888042e-06 NA NA NA hsa-miR-429 DAAM1 -0.456485631615963 0.806240953400535 -0.170483432113034 0.857808092963577 miRNATAP -0.101525246503503 0.00409320261536615 NA NA NA hsa-miR-452-5p DAAM1 -0.0504626418153507 0.973874641360401 -0.170483432113034 0.857808092963577 MirTarget -0.156517229568173 0.000254703292535222 NA NA NA hsa-miR-454-3p DAAM1 -0.101514866328011 0.843545158256191 -0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.166925285181881 0.00175859254883641 NA NA NA hsa-miR-548o-3p DAAM1 -0.191447572716994 0.517725546183501 -0.170483432113034 0.857808092963577 mirMAP -0.114031852333232 0.00528140836060873 NA NA NA hsa-miR-590-3p DAAM1 -0.279244755376859 0.59126669933662 -0.170483432113034 0.857808092963577 MirTarget;miRanda;mirMAP -0.128692560125035 0.000536645617060937 NA NA NA hsa-miR-92a-3p DAAM1 0.0278830870766349 0.993247426671713 -0.170483432113034 0.857808092963577 miRNATAP -0.192390375711452 2.38843044214745e-05 NA NA NA hsa-miR-141-5p DAAM2 -0.354590233549885 0.867642456336402 0.123197015155059 0.866241898438595 mirMAP -0.595158097965982 4.18174853054438e-16 NA NA NA hsa-miR-182-5p DAAM2 -0.104238497940557 0.973380614062243 0.123197015155059 0.866241898438595 mirMAP -0.358619355576489 1.47192349985391e-06 NA NA NA hsa-miR-18a-5p DAAM2 -0.498318455303917 0.61264091975585 0.123197015155059 0.866241898438595 miRNAWalker2_validate -0.45873784011012 1.14446934648213e-14 NA NA NA hsa-miR-193a-3p DAAM2 -0.247265785363732 0.654363581941634 0.123197015155059 0.866241898438595 miRanda -0.337316870064459 2.37054530124182e-05 NA NA NA hsa-miR-1976 DAAM2 -0.283448756688618 0.707004130216603 0.123197015155059 0.866241898438595 mirMAP -0.532582609955771 3.92410177495442e-08 NA NA NA hsa-miR-19b-3p DAAM2 -0.0268530183621474 0.986656783046572 0.123197015155059 0.866241898438595 miRNAWalker2_validate -0.59050098355468 4.00033091353882e-13 NA NA NA hsa-miR-335-5p DAAM2 -0.0284895175847679 0.973380867832231 0.123197015155059 0.866241898438595 mirMAP -0.559642794983272 6.39421905069849e-14 NA NA NA hsa-miR-339-5p DAAM2 -0.300425087100667 0.712912847076788 0.123197015155059 0.866241898438595 miRanda -0.547546638014412 8.84737831943075e-17 NA NA NA hsa-miR-361-3p DAAM2 -0.285313945920494 0.847726816983044 0.123197015155059 0.866241898438595 mirMAP -0.326968157486964 0.00993249663179331 NA NA NA hsa-miR-369-3p DAAM2 0.116576891957687 0.83230082995912 0.123197015155059 0.866241898438595 mirMAP -0.270121794606608 0.00211803000912154 NA NA NA hsa-miR-421 DAAM2 -0.182032017078616 0.734704500318599 0.123197015155059 0.866241898438595 PITA;miRanda -0.352816270039932 1.43302721484245e-05 NA NA NA hsa-miR-429 DAAM2 -0.456485631615963 0.806240953400535 0.123197015155059 0.866241898438595 miRNATAP -0.546180360150489 4.956191720599e-18 NA NA NA hsa-miR-589-3p DAAM2 -0.835836305204965 0.0112001563801511 0.123197015155059 0.866241898438595 mirMAP -0.350649199509711 7.79147478780687e-08 NA NA NA hsa-miR-590-3p DAAM2 -0.279244755376859 0.59126669933662 0.123197015155059 0.866241898438595 miRanda;mirMAP -0.575096394584599 6.27875129858233e-18 NA NA NA hsa-miR-592 DAAM2 -0.177670083168544 0.856226890424691 0.123197015155059 0.866241898438595 mirMAP -0.116291169902452 0.00126833211978792 NA NA NA hsa-miR-107 DKK1 -0.0365118169251648 0.988364120226869 2.12234217054464 0.0100076426738182 miRanda -1.06818126173056 0.00153469452605571 NA NA NA hsa-miR-16-2-3p DKK1 -0.36717860153421 0.546850726070016 2.12234217054464 0.0100076426738182 mirMAP -0.727503713353185 6.69781345912883e-05 NA NA NA hsa-miR-590-3p DKK1 -0.279244755376859 0.59126669933662 2.12234217054464 0.0100076426738182 PITA;miRanda;mirMAP;miRNATAP -0.610011651992684 0.000246218084097269 NA NA NA hsa-miR-142-3p DKK2 -0.154235241441331 0.946098054588918 0.674433136505868 0.218463005299489 miRanda -0.287731888562342 0.009784295223841 NA NA NA hsa-miR-193a-3p DKK2 -0.247265785363732 0.654363581941634 0.674433136505868 0.218463005299489 miRanda -0.337371222347827 0.00831119630033944 NA NA NA hsa-miR-221-3p DKK2 0.0906940388127513 0.959121118272534 0.674433136505868 0.218463005299489 miRNAWalker2_validate;miRTarBase -0.890094370168241 5.49123136277718e-08 NA NA NA hsa-miR-27a-3p DKK2 -0.123902317731458 0.958804393510999 0.674433136505868 0.218463005299489 miRNATAP -0.739748997527834 0.000647376426119641 NA NA NA hsa-miR-324-5p DKK2 -0.50063248413014 0.537416710557032 0.674433136505868 0.218463005299489 miRanda -0.685279382698123 1.13636449329792e-06 NA NA NA hsa-miR-335-5p DKK2 -0.0284895175847679 0.973380867832231 0.674433136505868 0.218463005299489 miRNAWalker2_validate -0.740205187739338 8.10644871869191e-10 NA NA NA hsa-miR-33a-3p DKK2 -0.794543849238581 0.0105203072007922 0.674433136505868 0.218463005299489 mirMAP -0.515970968191941 5.48116889312443e-06 NA NA NA hsa-miR-361-5p DKK2 -0.138735309928775 0.941495130308343 0.674433136505868 0.218463005299489 miRanda -0.986577790796155 1.46506525773545e-05 NA NA NA hsa-miR-374a-5p DKK2 -0.343007247142618 0.766921280269271 0.674433136505868 0.218463005299489 mirMAP -0.611865529730721 0.00163018467118069 NA NA NA hsa-miR-374b-5p DKK2 -0.285682091626878 0.83569830479965 0.674433136505868 0.218463005299489 mirMAP -0.895750662994789 1.36570969308441e-06 NA NA NA hsa-miR-486-5p DKK2 -0.547739229538641 0.696404149927963 0.674433136505868 0.218463005299489 miRanda;miRNATAP -0.393238090238234 1.33597603457378e-05 NA NA NA hsa-miR-576-5p DKK2 -0.506413219377403 0.417187951364173 0.674433136505868 0.218463005299489 mirMAP -0.819792337513585 4.7132301620388e-10 NA NA NA hsa-miR-590-3p DKK2 -0.279244755376859 0.59126669933662 0.674433136505868 0.218463005299489 miRanda;mirMAP;miRNATAP -0.756241189497093 3.14107282492043e-12 NA NA NA hsa-miR-590-5p DKK2 -0.547819833829572 0.472735645776647 0.674433136505868 0.218463005299489 miRanda -0.770227159553781 2.29895306202608e-11 NA NA NA hsa-miR-221-3p DVL2 0.0906940388127513 0.959121118272534 -0.167559306568992 0.882789212674878 miRNAWalker2_validate -0.107215494752155 0.0034025469139885 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-21-5p DVL3 -0.148920887107433 0.970240620972126 0.0230454436789396 0.987936840377638 mirMAP -0.130513305195752 0.0002925771275384 NA NA NA hsa-miR-106b-5p EP300 -0.297128724729339 0.869294443540749 -0.275785871935125 0.858275138267876 miRNATAP -0.130709049655062 0.000960073772533261 NA NA NA hsa-miR-26b-5p EP300 -0.0245931278499594 0.990377966314923 -0.275785871935125 0.858275138267876 miRNAWalker2_validate;miRNATAP -0.122462053179979 0.0081599533716202 NA NA NA hsa-miR-339-5p EP300 -0.300425087100667 0.712912847076788 -0.275785871935125 0.858275138267876 miRanda -0.107604978422911 0.000130192205849388 NA NA NA hsa-miR-369-3p EP300 0.116576891957687 0.83230082995912 -0.275785871935125 0.858275138267876 MirTarget;PITA;miRNATAP -0.151763068163101 1.43595410012867e-05 NA NA NA hsa-miR-374a-5p FBXW11 -0.343007247142618 0.766921280269271 0.0591555286850083 0.962033974207803 mirMAP -0.120232748570681 0.000160498273248043 NA NA NA hsa-miR-505-3p FBXW11 -0.469094267152605 0.690382680489578 0.0591555286850083 0.962033974207803 mirMAP -0.103431273126737 0.000111709512682406 NA NA NA hsa-miR-22-3p FRAT2 0.0592693913158495 0.986564295498741 -0.194463727237224 0.869741180023171 miRNAWalker2_validate;MirTarget;miRNATAP -0.190195907315066 0.00287842550547643 NA NA NA hsa-miR-1275 FZD1 -0.831342050607648 0.0803795852164229 -0.0511757191873929 0.959081690359456 MirTarget -0.11752493679076 0.000375152206570806 NA NA NA hsa-miR-146a-5p FZD1 -0.581292803346906 0.73685134936757 -0.0511757191873929 0.959081690359456 MirTarget -0.18270145041992 3.3371303321675e-05 NA NA NA hsa-miR-148b-5p FZD1 -0.236618793990305 0.43925706879726 -0.0511757191873929 0.959081690359456 MirTarget -0.276963845962678 3.19703916121763e-09 NA NA NA hsa-miR-186-5p FZD1 -0.318786974828757 0.85412722938961 -0.0511757191873929 0.959081690359456 mirMAP -0.442243854107384 6.58112949339573e-10 NA NA NA hsa-miR-192-5p FZD1 -0.117345487848223 0.972927287653137 -0.0511757191873929 0.959081690359456 miRNAWalker2_validate -0.29249446475231 1.60822915399963e-13 NA NA NA hsa-miR-200a-5p FZD1 -0.671005453811576 0.78126028567661 -0.0511757191873929 0.959081690359456 MirTarget -0.283079971493201 1.53230997569097e-09 NA NA NA hsa-miR-200b-5p FZD1 -0.502275384207405 0.722255155236927 -0.0511757191873929 0.959081690359456 MirTarget -0.337269077999376 1.11302413325129e-13 NA NA NA hsa-miR-29a-3p FZD1 0.01127474410284 0.996977020481272 -0.0511757191873929 0.959081690359456 mirMAP -0.413500580447596 6.69744408607844e-10 NA NA NA hsa-miR-29b-3p FZD1 -0.104016192263954 0.958988036765397 -0.0511757191873929 0.959081690359456 mirMAP -0.389589850217655 3.11370022041214e-15 NA NA NA hsa-miR-335-5p FZD1 -0.0284895175847679 0.973380867832231 -0.0511757191873929 0.959081690359456 miRNAWalker2_validate -0.287938175924094 7.09583918605026e-10 NA NA NA hsa-miR-577 FZD1 -1.06238199218774 0.326056761787754 -0.0511757191873929 0.959081690359456 MirTarget;PITA -0.193897696514949 8.76701831976043e-14 NA NA NA hsa-miR-590-3p FZD1 -0.279244755376859 0.59126669933662 -0.0511757191873929 0.959081690359456 miRanda -0.291958862049538 4.01010434726308e-12 NA NA NA hsa-miR-93-3p FZD1 -0.438355548962673 0.549902689385444 -0.0511757191873929 0.959081690359456 MirTarget -0.331297673037746 1.33030931304845e-11 NA NA NA hsa-miR-140-3p FZD10 -0.369894078407761 0.864762211761539 0.672999650470658 0.343524502785402 miRNATAP -0.874493581410679 0.0082353652076572 NA NA NA hsa-miR-15b-5p FZD10 -0.272614787130877 0.87096541832188 0.672999650470658 0.343524502785402 miRNATAP -0.760641203413187 0.000336442978733665 NA NA NA hsa-miR-16-5p FZD10 0.0135949734723564 0.994476223855607 0.672999650470658 0.343524502785402 miRNATAP -0.661414593664301 0.00183454732995892 NA NA NA hsa-miR-92b-3p FZD10 -0.569866984318692 0.689321861489779 0.672999650470658 0.343524502785402 miRNATAP -0.846940680279183 2.00455998708371e-06 NA NA NA hsa-miR-30a-3p FZD3 0.250338313897394 0.917094926793447 -0.709666581031871 0.308168084051882 mirMAP -0.502888110666901 2.05499958948805e-07 NA NA NA hsa-miR-30a-5p FZD3 0.219472325612346 0.933954023293816 -0.709666581031871 0.308168084051882 MirTarget;miRNATAP -0.727481268646512 1.34518538564639e-11 NA NA NA hsa-miR-30e-5p FZD3 -0.0657075181381011 0.979684509181941 -0.709666581031871 0.308168084051882 MirTarget -0.305355951237959 0.00776468229563295 NA NA NA hsa-let-7a-3p FZD4 -0.215598045625677 0.85543299203799 0.0878618904726611 0.926402581549652 mirMAP -0.24235415493525 1.98163871311651e-05 NA NA NA hsa-let-7d-5p FZD4 -0.139747701175051 0.934164162708487 0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.378744975720612 5.05342251895716e-06 NA NA NA hsa-let-7f-1-3p FZD4 -0.31101436822914 0.693407210545374 0.0878618904726611 0.926402581549652 mirMAP -0.331002599507533 1.97156389472645e-05 NA NA NA hsa-let-7f-5p FZD4 0.048789917034723 0.987280455481631 0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.240219811220551 0.00274263197108385 NA NA NA hsa-let-7g-3p FZD4 -0.489638373791485 0.62941522205833 0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.250526051982766 5.7607717020182e-09 NA NA NA hsa-let-7g-5p FZD4 -0.200947212961157 0.922992045181955 0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.445951284220326 1.95048404448625e-08 NA NA NA hsa-miR-106b-5p FZD4 -0.297128724729339 0.869294443540749 0.0878618904726611 0.926402581549652 miRNATAP -0.462968844683632 9.22394261685133e-17 NA NA NA hsa-miR-107 FZD4 -0.0365118169251648 0.988364120226869 0.0878618904726611 0.926402581549652 miRNATAP -0.292893621156472 0.000771321721536902 NA NA NA hsa-miR-10a-5p FZD4 0.0740585720685925 0.983770933356406 0.0878618904726611 0.926402581549652 MirTarget -0.280584207335698 6.27494988897258e-09 NA NA NA hsa-miR-130b-3p FZD4 -0.221667315324818 0.824660172394714 0.0878618904726611 0.926402581549652 mirMAP -0.412310564071406 1.63661208275803e-16 NA NA NA hsa-miR-141-3p FZD4 -0.31994058840327 0.87774106909065 0.0878618904726611 0.926402581549652 TargetScan -0.349055161798277 1.71327499085363e-17 NA NA NA hsa-miR-15a-5p FZD4 -0.0674049094129128 0.964835434214123 0.0878618904726611 0.926402581549652 MirTarget -0.39947651989731 2.8153629018267e-11 NA NA NA hsa-miR-15b-5p FZD4 -0.272614787130877 0.87096541832188 0.0878618904726611 0.926402581549652 MirTarget -0.322385382369299 1.66717339874602e-08 NA NA NA hsa-miR-16-5p FZD4 0.0135949734723564 0.994476223855607 0.0878618904726611 0.926402581549652 MirTarget -0.38640102816812 5.05353596618766e-12 NA NA NA hsa-miR-17-3p FZD4 0.100221625453134 0.960113387014848 0.0878618904726611 0.926402581549652 MirTarget -0.344296092854496 1.16384737811129e-11 NA NA NA hsa-miR-17-5p FZD4 -0.175448849583061 0.934544015912731 0.0878618904726611 0.926402581549652 TargetScan -0.385278735283471 2.4212409069261e-20 NA NA NA hsa-miR-185-5p FZD4 -0.294432218239008 0.820591478398594 0.0878618904726611 0.926402581549652 MirTarget -0.25931120793545 0.000355854644349803 NA NA NA hsa-miR-186-5p FZD4 -0.318786974828757 0.85412722938961 0.0878618904726611 0.926402581549652 mirMAP -0.394785495166536 2.71490669306833e-08 NA NA NA hsa-miR-192-5p FZD4 -0.117345487848223 0.972927287653137 0.0878618904726611 0.926402581549652 miRNAWalker2_validate;mirMAP -0.315929034898543 2.09067678228179e-16 NA NA NA hsa-miR-200b-3p FZD4 -0.426401948379212 0.863957108574195 0.0878618904726611 0.926402581549652 mirMAP -0.330735975746675 9.2070049888302e-12 NA NA NA hsa-miR-200c-3p FZD4 -0.437282635857873 0.887118598436407 0.0878618904726611 0.926402581549652 mirMAP -0.389224630715533 2.0181642631006e-15 NA NA NA hsa-miR-20a-5p FZD4 -0.179153323927949 0.928118119139752 0.0878618904726611 0.926402581549652 miRNATAP -0.326109320648211 1.14866355828259e-14 NA NA NA hsa-miR-24-3p FZD4 -0.0484778924256624 0.985274054814493 0.0878618904726611 0.926402581549652 miRNAWalker2_validate -0.401582174051184 0.000106106750154132 NA NA NA hsa-miR-25-3p FZD4 -0.457540448732733 0.878574066837636 0.0878618904726611 0.926402581549652 mirMAP -0.454137375975653 1.0437216784944e-10 NA NA NA hsa-miR-27a-3p FZD4 -0.123902317731458 0.958804393510999 0.0878618904726611 0.926402581549652 miRNATAP -0.369388638057351 6.5207729341799e-06 NA NA NA hsa-miR-301a-3p FZD4 -0.105312511901769 0.831686745977347 0.0878618904726611 0.926402581549652 mirMAP -0.238068583095689 6.48876495696042e-08 NA NA NA hsa-miR-32-3p FZD4 -0.568003960723004 0.13133163420273 0.0878618904726611 0.926402581549652 mirMAP -0.26908806822694 3.5631981260887e-14 NA NA NA hsa-miR-32-5p FZD4 -0.05993267619119 0.952975951594959 0.0878618904726611 0.926402581549652 mirMAP -0.272773834348837 3.46453179321418e-08 NA NA NA hsa-miR-324-3p FZD4 -0.424387380347173 0.661528309116338 0.0878618904726611 0.926402581549652 miRNATAP -0.307177917489889 7.75266283928872e-07 NA NA NA hsa-miR-33a-3p FZD4 -0.794543849238581 0.0105203072007922 0.0878618904726611 0.926402581549652 mirMAP -0.211644634278252 9.28824887249447e-07 NA NA NA hsa-miR-361-5p FZD4 -0.138735309928775 0.941495130308343 0.0878618904726611 0.926402581549652 mirMAP -0.367474368087195 2.36770477912264e-05 NA NA NA hsa-miR-375 FZD4 -0.690952835064582 0.831716365337668 0.0878618904726611 0.926402581549652 miRNAWalker2_validate;miRNATAP -0.13178579107507 5.27238238037549e-05 NA NA NA hsa-miR-424-5p FZD4 0.247080963500746 0.870154571783568 0.0878618904726611 0.926402581549652 MirTarget -0.144945609072968 0.000796475929538292 NA NA NA hsa-miR-429 FZD4 -0.456485631615963 0.806240953400535 0.0878618904726611 0.926402581549652 mirMAP -0.302376022892235 5.25763775406751e-15 NA NA NA hsa-miR-452-5p FZD4 -0.0504626418153507 0.973874641360401 0.0878618904726611 0.926402581549652 miRNATAP -0.165583048875209 0.000875694384307184 NA NA NA hsa-miR-454-3p FZD4 -0.101514866328011 0.843545158256191 0.0878618904726611 0.926402581549652 mirMAP -0.332875145499982 3.69563381519303e-08 NA NA NA hsa-miR-455-3p FZD4 -0.356341681711462 0.824635754440661 0.0878618904726611 0.926402581549652 mirMAP -0.167658801626423 0.000105569165309893 NA NA NA hsa-miR-484 FZD4 -0.179977202691249 0.886333755572375 0.0878618904726611 0.926402581549652 PITA -0.36169259047709 9.83073480624767e-09 NA NA NA hsa-miR-505-5p FZD4 -0.555858818875454 0.317679205488749 0.0878618904726611 0.926402581549652 MirTarget -0.214180288854279 2.59147925946339e-05 NA NA NA hsa-miR-548o-3p FZD4 -0.191447572716994 0.517725546183501 0.0878618904726611 0.926402581549652 MirTarget;mirMAP -0.186630956887194 7.1182737756345e-05 NA NA NA hsa-miR-576-5p FZD4 -0.506413219377403 0.417187951364173 0.0878618904726611 0.926402581549652 mirMAP -0.294023395404864 5.75088811667438e-09 NA NA NA hsa-miR-589-3p FZD4 -0.835836305204965 0.0112001563801511 0.0878618904726611 0.926402581549652 mirMAP -0.20050840471974 3.94945449551434e-07 NA NA NA hsa-miR-590-3p FZD4 -0.279244755376859 0.59126669933662 0.0878618904726611 0.926402581549652 miRanda;mirMAP;miRNATAP -0.316895774015859 8.83616028088734e-15 NA NA NA hsa-miR-590-5p FZD4 -0.547819833829572 0.472735645776647 0.0878618904726611 0.926402581549652 mirMAP -0.364461844197489 1.17961583838464e-17 NA NA NA hsa-miR-629-3p FZD4 -0.495402745812008 0.333967382214384 0.0878618904726611 0.926402581549652 miRNATAP -0.215719580317411 1.1650369483956e-07 NA NA NA hsa-miR-7-1-3p FZD4 -0.462485777435991 0.665899751398166 0.0878618904726611 0.926402581549652 mirMAP -0.246259494536549 7.66825345676451e-07 NA NA NA hsa-miR-92a-3p FZD4 0.0278830870766349 0.993247426671713 0.0878618904726611 0.926402581549652 mirMAP -0.444671994040866 1.67578436949747e-19 NA NA NA hsa-miR-940 FZD4 -0.225788347550697 0.680055767105815 0.0878618904726611 0.926402581549652 miRNATAP -0.208968947832091 6.88297555159904e-09 NA NA NA hsa-miR-98-5p FZD4 -0.168162186023221 0.898802461503524 0.0878618904726611 0.926402581549652 MirTarget -0.36892820953079 8.02707007553463e-08 NA NA NA hsa-miR-100-5p FZD5 0.0230258429671419 0.992818348620337 -0.365944021258741 0.803644920287012 MirTarget;miRNATAP -0.161373951724948 1.91022558437002e-07 NA NA NA hsa-miR-30a-3p FZD5 0.250338313897394 0.917094926793447 -0.365944021258741 0.803644920287012 mirMAP -0.176897321104786 0.000788197434899611 NA NA NA hsa-miR-99a-5p FZD5 -0.0816417843399995 0.957743991295435 -0.365944021258741 0.803644920287012 MirTarget;miRNATAP -0.138923742595564 1.05411725584288e-08 NA NA NA hsa-miR-99b-5p FZD5 0.0468672968421853 0.987817055855752 -0.365944021258741 0.803644920287012 MirTarget;miRNATAP -0.182676788932937 0.00135694110088436 NA NA NA hsa-miR-126-5p FZD6 0.0815213541035824 0.956637332055185 -0.116202458329262 0.917959139627307 mirMAP;miRNATAP -0.203343882862267 0.000514833756074637 NA NA NA hsa-miR-130a-3p FZD6 0.0910074087716906 0.929098200371948 -0.116202458329262 0.917959139627307 MirTarget -0.151442534371088 0.00132131645480315 NA NA NA hsa-miR-140-5p FZD6 -0.229213026275906 0.847330111738616 -0.116202458329262 0.917959139627307 MirTarget;miRanda -0.277103508018634 2.94288580107927e-05 NA NA NA hsa-miR-342-3p FZD6 -0.371626144515113 0.77313668985267 -0.116202458329262 0.917959139627307 miRanda -0.155141338349412 0.000772377404667349 NA NA NA hsa-miR-377-3p FZD6 -0.0435868040110954 0.893514136702459 -0.116202458329262 0.917959139627307 MirTarget -0.125596119648936 0.0018297319558545 NA NA NA hsa-miR-654-3p FZD6 0.0699248385448739 0.946997748280675 -0.116202458329262 0.917959139627307 MirTarget -0.18305400928971 0.000261587621170951 NA NA NA hsa-miR-655-3p FZD6 0.225525683904601 0.432294495359122 -0.116202458329262 0.917959139627307 MirTarget -0.143568409731071 0.00234398104814069 NA NA NA hsa-miR-106b-5p FZD7 -0.297128724729339 0.869294443540749 0.141758736826612 0.887530668345864 miRNATAP -0.310495407892443 0.000271077453576642 NA NA NA hsa-miR-130b-5p FZD7 -0.6472141103776 0.379096015222509 0.141758736826612 0.887530668345864 mirMAP -0.392592588060961 2.5891496920303e-08 NA NA NA hsa-miR-142-3p FZD7 -0.154235241441331 0.946098054588918 0.141758736826612 0.887530668345864 miRanda -0.218286508217908 0.000324756034389622 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-186-5p FZD7 -0.318786974828757 0.85412722938961 0.141758736826612 0.887530668345864 mirMAP -0.348883372385438 0.000843840090060864 NA NA NA hsa-miR-192-5p FZD7 -0.117345487848223 0.972927287653137 0.141758736826612 0.887530668345864 miRNAWalker2_validate -0.249111583108782 2.02554742642096e-05 NA NA NA hsa-miR-20a-5p FZD7 -0.179153323927949 0.928118119139752 0.141758736826612 0.887530668345864 miRNATAP -0.188776672406327 0.00334789787042153 NA NA NA hsa-miR-215-5p FZD7 -0.142648109361913 0.94480931294964 0.141758736826612 0.887530668345864 miRNAWalker2_validate -0.145178549109679 0.000105418654498185 NA NA NA hsa-miR-27a-3p FZD7 -0.123902317731458 0.958804393510999 0.141758736826612 0.887530668345864 MirTarget;miRNATAP -0.387909908210953 0.00113960545475631 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-33a-3p FZD7 -0.794543849238581 0.0105203072007922 0.141758736826612 0.887530668345864 mirMAP;miRNATAP -0.270382002512775 1.50067738257573e-05 NA NA NA hsa-miR-429 FZD7 -0.456485631615963 0.806240953400535 0.141758736826612 0.887530668345864 miRanda;miRNATAP -0.265085451054369 5.24631037789406e-06 NA NA NA hsa-miR-486-5p FZD7 -0.547739229538641 0.696404149927963 0.141758736826612 0.887530668345864 miRanda -0.145351513590878 0.00377760791344002 NA NA NA hsa-miR-590-3p FZD7 -0.279244755376859 0.59126669933662 0.141758736826612 0.887530668345864 miRanda -0.262788794497016 2.00216517482804e-05 NA NA NA hsa-miR-324-5p FZD8 -0.50063248413014 0.537416710557032 0.0863023356417161 0.912182129471101 miRanda -0.304244224471374 2.30626517977631e-05 NA NA NA hsa-miR-335-5p FZD8 -0.0284895175847679 0.973380867832231 0.0863023356417161 0.912182129471101 miRNAWalker2_validate -0.20789770534199 0.00096266610107808 NA NA NA hsa-miR-362-3p FZD8 -0.721040238345347 0.0345881362485733 0.0863023356417161 0.912182129471101 miRanda -0.198500222894791 0.000375690442920201 NA NA NA hsa-miR-374b-5p FZD8 -0.285682091626878 0.83569830479965 0.0863023356417161 0.912182129471101 miRNAWalker2_validate -0.269005251180704 0.00494097809194219 NA NA NA hsa-miR-375 FZD8 -0.690952835064582 0.831716365337668 0.0863023356417161 0.912182129471101 miRNAWalker2_validate -0.144781056445186 0.000895163191296766 27276676 MicroRNA 375 suppresses human colorectal cancer metastasis by targeting Frizzled 8; Therefore we concluded that miR-375 functions as a tumor-suppressive microRNA by directly acting upon FZD8 which may serve as a new therapeutic target to inhibit tumor metastasis in CRC metastasis colorectal cancer hsa-miR-429 FZD8 -0.456485631615963 0.806240953400535 0.0863023356417161 0.912182129471101 miRanda -0.252955344596221 2.43003733030416e-06 NA NA NA hsa-miR-590-3p FZD8 -0.279244755376859 0.59126669933662 0.0863023356417161 0.912182129471101 miRanda -0.362794235468147 5.60279970711268e-11 NA NA NA hsa-miR-7-1-3p FZD8 -0.462485777435991 0.665899751398166 0.0863023356417161 0.912182129471101 MirTarget -0.340287338649772 2.58862272082261e-07 NA NA NA hsa-miR-132-3p GSK3B -0.244143673573889 0.871752726220643 -0.0279273799391531 0.984168396316634 mirMAP;miRNATAP -0.110221716663843 0.000912142142693881 NA NA NA hsa-miR-146b-3p GSK3B -0.408862981477661 0.762520540478861 -0.0279273799391531 0.984168396316634 miRNATAP -0.124674628963768 4.92920707796624e-08 NA NA NA hsa-miR-146b-5p GSK3B -0.402662509440887 0.837510937985091 -0.0279273799391531 0.984168396316634 miRanda -0.144433253868449 1.55437010316677e-09 NA NA NA hsa-miR-155-5p GSK3B -0.407235807706004 0.828669616718496 -0.0279273799391531 0.984168396316634 miRNAWalker2_validate;miRNATAP -0.101330604682835 1.443796438774e-06 NA NA NA hsa-miR-212-3p GSK3B -0.0224067199236484 0.973232008101458 -0.0279273799391531 0.984168396316634 mirMAP;miRNATAP -0.114396409575091 1.59972400030542e-05 NA NA NA hsa-let-7a-3p LEF1 -0.215598045625677 0.85543299203799 0.372363769452591 0.672169186275724 miRNATAP -0.376892958550269 4.01542672003822e-05 NA NA NA hsa-miR-26b-5p LEF1 -0.0245931278499594 0.990377966314923 0.372363769452591 0.672169186275724 miRNATAP -0.418971196571213 0.000163882839340634 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-335-3p LEF1 -0.244830745789445 0.88450019116631 0.372363769452591 0.672169186275724 mirMAP -0.216958845734393 0.00449894889910492 NA NA NA hsa-miR-33a-3p LEF1 -0.794543849238581 0.0105203072007922 0.372363769452591 0.672169186275724 miRNATAP -0.236080809003934 0.000829038399450042 NA NA NA hsa-miR-590-3p LEF1 -0.279244755376859 0.59126669933662 0.372363769452591 0.672169186275724 PITA;miRanda;mirMAP -0.406214238447069 1.97986726304738e-09 NA NA NA hsa-miR-7-1-3p LEF1 -0.462485777435991 0.665899751398166 0.372363769452591 0.672169186275724 mirMAP -0.37128315594906 4.16815851332667e-06 NA NA NA hsa-miR-29c-3p LRP6 0.162451700202704 0.942720457512509 0.0092958635862086 0.994164444256216 miRNATAP -0.117273903260117 0.000337062728866153 NA NA NA hsa-miR-130b-3p MAPK10 -0.221667315324818 0.824660172394714 0.277853609916948 0.499757905156418 miRNATAP -0.832310234327384 2.2381048276646e-17 NA NA NA hsa-miR-193a-3p MAPK10 -0.247265785363732 0.654363581941634 0.277853609916948 0.499757905156418 miRanda;miRNATAP -0.252213365553003 0.00870398994376484 NA NA NA hsa-miR-19a-3p MAPK10 -0.206793507801887 0.844637784802316 0.277853609916948 0.499757905156418 miRNATAP -0.684018875973696 4.827389622141e-18 NA NA NA hsa-miR-19b-3p MAPK10 -0.0268530183621474 0.986656783046572 0.277853609916948 0.499757905156418 miRNATAP -0.696419816886425 6.76561876995665e-13 NA NA NA hsa-miR-221-3p MAPK10 0.0906940388127513 0.959121118272534 0.277853609916948 0.499757905156418 miRNATAP -0.85742573028989 1.01791917727309e-12 NA NA NA hsa-miR-222-3p MAPK10 -0.0265849318772702 0.984005474689108 0.277853609916948 0.499757905156418 miRNATAP -0.880593901403205 6.71481319542536e-17 NA NA NA hsa-miR-29a-3p MAPK10 0.01127474410284 0.996977020481272 0.277853609916948 0.499757905156418 miRNATAP -0.691098479445333 1.45128452412974e-07 NA NA NA hsa-miR-29b-3p MAPK10 -0.104016192263954 0.958988036765397 0.277853609916948 0.499757905156418 miRNATAP -0.761303371269869 1.76988052622429e-15 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 -0.105312511901769 0.831686745977347 0.277853609916948 0.499757905156418 miRNATAP -0.612353493044439 4.61795457460633e-13 NA NA NA hsa-miR-30d-3p MAPK10 -0.123474741320298 0.814905367625791 0.277853609916948 0.499757905156418 mirMAP -0.796380211200875 1.85348051868985e-13 NA NA NA hsa-miR-30e-3p MAPK10 -0.220498559176349 0.938660731870214 0.277853609916948 0.499757905156418 mirMAP -0.516722605634317 0.00602241545561428 NA NA NA hsa-miR-330-3p MAPK10 0.00298687748748416 0.994504006750491 0.277853609916948 0.499757905156418 PITA;miRNATAP -0.375477945370297 0.000760398661857965 NA NA NA hsa-miR-429 MAPK10 -0.456485631615963 0.806240953400535 0.277853609916948 0.499757905156418 miRNATAP -0.63546405917023 3.52018243839143e-17 NA NA NA hsa-miR-450b-5p MAPK10 -0.0136687538973108 0.983149761399849 0.277853609916948 0.499757905156418 mirMAP -0.334790980428701 0.00164827821846065 NA NA NA hsa-miR-454-3p MAPK10 -0.101514866328011 0.843545158256191 0.277853609916948 0.499757905156418 miRNATAP -0.717456429396768 1.33940482149645e-09 NA NA NA hsa-miR-455-5p MAPK10 -0.139599153671262 0.865744220236311 0.277853609916948 0.499757905156418 miRanda -0.270878318986493 0.00909782838990037 NA NA NA hsa-miR-548o-3p MAPK10 -0.191447572716994 0.517725546183501 0.277853609916948 0.499757905156418 mirMAP -0.462430047984935 4.46197714322552e-07 NA NA NA hsa-miR-582-5p MAPK10 -0.399450205475138 0.581227478860085 0.277853609916948 0.499757905156418 PITA -0.605577911431605 1.99297551024098e-08 NA NA NA hsa-miR-590-3p MAPK10 -0.279244755376859 0.59126669933662 0.277853609916948 0.499757905156418 miRanda;mirMAP -0.669311815061267 4.2846409042703e-17 NA NA NA hsa-miR-590-5p MAPK10 -0.547819833829572 0.472735645776647 0.277853609916948 0.499757905156418 PITA;miRanda;miRNATAP -0.775102686172998 6.76449100692106e-21 NA NA NA hsa-miR-935 MAPK10 0.0536667023984385 0.939418255464024 0.277853609916948 0.499757905156418 miRNATAP -0.225220660326491 1.42825991928949e-07 NA NA NA hsa-miR-940 MAPK10 -0.225788347550697 0.680055767105815 0.277853609916948 0.499757905156418 PITA;miRNATAP -0.415226368453551 5.09031496952449e-09 NA NA NA hsa-miR-130a-3p MAPK8 0.0910074087716906 0.929098200371948 -0.319170851710442 0.713899940923572 mirMAP -0.147493968259864 1.00993606990742e-06 NA NA NA hsa-miR-193b-3p MAPK8 0.0672068426635715 0.951480422273678 -0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106177901094541 0.00010813031062645 NA NA NA hsa-miR-214-3p MAPK8 0.198015895663265 0.797041683257943 -0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106280310352835 1.00012795110538e-06 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 -0.0785922550675187 0.93169760098231 -0.319170851710442 0.713899940923572 mirMAP -0.129099178124462 4.99897569863785e-06 NA NA NA hsa-miR-30b-5p MAPK8 -0.0121430518253582 0.994622896704513 -0.319170851710442 0.713899940923572 mirMAP -0.118491315163398 4.11391777534363e-05 NA NA NA hsa-miR-30c-5p MAPK8 -0.298383882401475 0.865809030482001 -0.319170851710442 0.713899940923572 mirMAP -0.136394758639834 0.00107809048076701 NA NA NA hsa-miR-376a-5p MAPK8 0.0978680856849549 0.773217338913054 -0.319170851710442 0.713899940923572 mirMAP -0.102493277664627 6.72583489111155e-05 NA NA NA hsa-miR-495-3p MAPK8 0.00168200867117596 0.997533662527025 -0.319170851710442 0.713899940923572 mirMAP -0.146650526517664 7.87292470161155e-05 NA NA NA hsa-let-7i-5p MAPK9 -0.200792135853451 0.922018647874073 -0.0687722126219112 0.958326759664496 miRNATAP -0.139568596213236 0.00470113649742568 NA NA NA hsa-miR-199a-3p MAPK9 0.0782166873040424 0.973766909565326 -0.0687722126219112 0.958326759664496 miRNAWalker2_validate -0.100016761572209 0.00211211499601589 NA NA NA hsa-miR-126-3p MMP7 -0.106293136341574 0.963670566555251 -0.276459182384981 0.831441864604979 miRNAWalker2_validate -0.722864708331936 0.000783652940961068 NA NA NA hsa-miR-590-3p MMP7 -0.279244755376859 0.59126669933662 -0.276459182384981 0.831441864604979 miRanda -0.388494612023758 0.00681400444644842 NA NA NA hsa-miR-590-5p MMP7 -0.547819833829572 0.472735645776647 -0.276459182384981 0.831441864604979 miRanda -0.525145355146763 0.000505782911901656 NA NA NA hsa-miR-320b MYC -0.23561798088153 0.859222532827992 -0.445372871610816 0.811492365164222 miRNAWalker2_validate -0.243607030835589 0.000321638494084035 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-132-3p NFAT5 -0.244143673573889 0.871752726220643 0.236883935946431 0.868755608472163 miRNATAP -0.303143600097309 2.16558109693786e-06 NA NA NA hsa-miR-140-3p NFAT5 -0.369894078407761 0.864762211761539 0.236883935946431 0.868755608472163 miRNATAP -0.225328079189035 0.00235415520685202 NA NA NA hsa-miR-146b-5p NFAT5 -0.402662509440887 0.837510937985091 0.236883935946431 0.868755608472163 miRanda -0.200410606753385 2.59202637244169e-05 NA NA NA hsa-miR-155-5p NFAT5 -0.407235807706004 0.828669616718496 0.236883935946431 0.868755608472163 mirMAP;miRNATAP -0.15151678093381 0.000258720624622913 NA NA NA hsa-miR-21-3p NFAT5 -0.395016549347053 0.87819982773565 0.236883935946431 0.868755608472163 MirTarget -0.181552783273077 0.000288869690237049 NA NA NA hsa-miR-21-5p NFAT5 -0.148920887107433 0.970240620972126 0.236883935946431 0.868755608472163 miRNAWalker2_validate;mirMAP -0.286300896256841 5.47270739628322e-05 NA NA NA hsa-miR-511-5p NFAT5 -0.308591187445274 0.607200373476563 0.236883935946431 0.868755608472163 MirTarget -0.109843348298306 0.00293390271527846 NA NA NA hsa-miR-582-3p NFAT5 -0.2334649592375 0.897678119160318 0.236883935946431 0.868755608472163 MirTarget -0.170498476348806 0.000104354261623335 NA NA NA hsa-miR-582-5p NFAT5 -0.399450205475138 0.581227478860085 0.236883935946431 0.868755608472163 MirTarget;PITA;miRNATAP -0.146117556547861 0.00140030250954287 NA NA NA hsa-miR-889-3p NFAT5 0.16596974586203 0.848786745366373 0.236883935946431 0.868755608472163 MirTarget -0.165016738249516 0.00648208856160109 NA NA NA hsa-miR-92b-3p NFAT5 -0.569866984318692 0.689321861489779 0.236883935946431 0.868755608472163 miRNATAP -0.184775604374122 3.95589693734067e-06 NA NA NA hsa-miR-421 NFATC1 -0.182032017078616 0.734704500318599 -0.122281733605435 0.852345442732836 miRanda -0.575230730616861 5.87588180760931e-11 NA NA NA hsa-miR-940 NFATC1 -0.225788347550697 0.680055767105815 -0.122281733605435 0.852345442732836 PITA -0.297982460990984 9.74621969187875e-06 NA NA NA hsa-miR-130b-5p NFATC2 -0.6472141103776 0.379096015222509 0.20813885004158 0.707327065065389 MirTarget -0.371671936709306 0.000945478291859101 NA NA NA hsa-miR-16-2-3p NFATC2 -0.36717860153421 0.546850726070016 0.20813885004158 0.707327065065389 mirMAP -0.321323681153577 0.00260222712022902 NA NA NA hsa-miR-182-5p NFATC2 -0.104238497940557 0.973380614062243 0.20813885004158 0.707327065065389 mirMAP -0.265681273078806 0.00971009673872175 NA NA NA hsa-miR-200b-5p NFATC2 -0.502275384207405 0.722255155236927 0.20813885004158 0.707327065065389 mirMAP -0.305745975197229 0.00378458633137365 NA NA NA hsa-miR-26b-3p NFATC2 -0.363222538866814 0.681115126930068 0.20813885004158 0.707327065065389 MirTarget -0.317033936764729 0.00865242756037893 NA NA NA hsa-miR-31-3p NFATC2 0.199700996192121 0.762032341762692 0.20813885004158 0.707327065065389 MirTarget -0.235283031776912 5.29901232164249e-06 NA NA NA hsa-miR-340-5p NFATC2 -0.00276909425328853 0.99757361161055 0.20813885004158 0.707327065065389 miRNATAP -0.352511827102355 0.00983626337497569 NA NA NA hsa-miR-484 NFATC2 -0.179977202691249 0.886333755572375 0.20813885004158 0.707327065065389 MirTarget -0.415370166828549 0.00430698140074031 NA NA NA hsa-miR-590-3p NFATC2 -0.279244755376859 0.59126669933662 0.20813885004158 0.707327065065389 mirMAP -0.338313979685588 0.000466556910823497 NA NA NA hsa-miR-7-1-3p NFATC2 -0.462485777435991 0.665899751398166 0.20813885004158 0.707327065065389 mirMAP -0.334924596713898 0.00323544853973565 NA NA NA hsa-miR-7-5p NFATC2 0.209645143210379 0.773705612298441 0.20813885004158 0.707327065065389 MirTarget;miRNATAP -0.222229993016084 0.00222704126347517 NA NA NA hsa-miR-1254 NFATC4 -0.488929355953681 0.19551794273322 0.226055021146126 0.800900855175489 MirTarget -0.168494924567814 0.000786858710678943 NA NA NA hsa-miR-130b-5p NFATC4 -0.6472141103776 0.379096015222509 0.226055021146126 0.800900855175489 mirMAP -0.233289219374898 0.000130008396840311 NA NA NA hsa-miR-15b-3p NFATC4 -0.557749208157585 0.609181305423188 0.226055021146126 0.800900855175489 mirMAP -0.270368257837691 2.79109512958001e-05 NA NA NA hsa-miR-29a-3p NFATC4 0.01127474410284 0.996977020481272 0.226055021146126 0.800900855175489 miRNATAP -0.258362450735976 0.00188238181514646 NA NA NA hsa-miR-29b-3p NFATC4 -0.104016192263954 0.958988036765397 0.226055021146126 0.800900855175489 miRNATAP -0.225170145334363 0.000330589653812401 NA NA NA hsa-miR-320c NFATC4 -0.577462251570141 0.113597318870228 0.226055021146126 0.800900855175489 miRanda;mirMAP -0.136540488247642 0.00651845172795593 NA NA NA hsa-miR-361-3p NFATC4 -0.285313945920494 0.847726816983044 0.226055021146126 0.800900855175489 mirMAP -0.242143644855398 0.00961205807335463 NA NA NA hsa-miR-429 NFATC4 -0.456485631615963 0.806240953400535 0.226055021146126 0.800900855175489 miRNATAP -0.213342690177861 1.64741561365079e-05 NA NA NA hsa-miR-532-5p NFATC4 -0.349665553500088 0.878948352437467 0.226055021146126 0.800900855175489 mirMAP -0.261553245010297 2.98639232810069e-05 NA NA NA hsa-miR-625-5p NFATC4 -0.690759472145277 0.210306534567564 0.226055021146126 0.800900855175489 mirMAP -0.142491700464098 0.00216106794254422 NA NA NA hsa-miR-629-3p NFATC4 -0.495402745812008 0.333967382214384 0.226055021146126 0.800900855175489 mirMAP -0.197806130594455 8.82960626285602e-05 NA NA NA hsa-let-7a-5p NKD1 -0.0620211756550422 0.985006886285188 1.2522994182732 0.260002383804271 TargetScan -0.83997772532673 0.00326453234388339 NA NA NA hsa-miR-330-5p NKD1 -0.283418953659271 0.815687101334695 1.2522994182732 0.260002383804271 miRanda;miRNATAP -0.730109518905697 0.000354165413242501 NA NA NA hsa-let-7b-5p NLK -0.228773940533783 0.938952933213741 0.214434715599375 0.830839712962495 miRNATAP -0.130424977621627 0.00311102435446934 NA NA NA hsa-let-7e-5p NLK 0.211156073215582 0.922335699862928 0.214434715599375 0.830839712962495 miRNATAP -0.143798339328613 0.00232162255220557 NA NA NA hsa-let-7i-5p NLK -0.200792135853451 0.922018647874073 0.214434715599375 0.830839712962495 miRNATAP -0.185812755181517 0.00112341117007832 NA NA NA hsa-miR-132-3p NLK -0.244143673573889 0.871752726220643 0.214434715599375 0.830839712962495 miRNATAP -0.198155050215153 3.50435694338891e-05 NA NA NA hsa-miR-146b-5p NLK -0.402662509440887 0.837510937985091 0.214434715599375 0.830839712962495 miRanda -0.19099789381006 4.66750054492802e-08 NA NA NA hsa-miR-330-5p NLK -0.283418953659271 0.815687101334695 0.214434715599375 0.830839712962495 MirTarget;PITA;miRanda;miRNATAP -0.119789137803744 0.00367235842016029 NA NA NA hsa-miR-342-3p NLK -0.371626144515113 0.77313668985267 0.214434715599375 0.830839712962495 miRanda -0.124795455162205 7.92183179587525e-05 NA NA NA hsa-miR-511-5p NLK -0.308591187445274 0.607200373476563 0.214434715599375 0.830839712962495 MirTarget -0.117056015401763 1.64388218292278e-05 NA NA NA hsa-miR-582-5p NLK -0.399450205475138 0.581227478860085 0.214434715599375 0.830839712962495 miRNATAP -0.110737279228243 0.00112944181508768 NA NA NA hsa-miR-130b-3p PLCB1 -0.221667315324818 0.824660172394714 0.585724538908979 0.503249899338964 miRNATAP -0.346654626715993 0.000547199373710532 NA NA NA hsa-miR-140-3p PLCB1 -0.369894078407761 0.864762211761539 0.585724538908979 0.503249899338964 PITA -0.529575232741916 0.00196728432959414 NA NA NA hsa-miR-16-2-3p PLCB1 -0.36717860153421 0.546850726070016 0.585724538908979 0.503249899338964 mirMAP -0.322346426435825 0.00030464248725077 NA NA NA hsa-miR-17-5p PLCB1 -0.175448849583061 0.934544015912731 0.585724538908979 0.503249899338964 TargetScan;miRNATAP -0.250067522224842 0.00345877682972104 NA NA NA hsa-miR-19a-3p PLCB1 -0.206793507801887 0.844637784802316 0.585724538908979 0.503249899338964 miRNATAP -0.230842601387747 0.00455153592697883 NA NA NA hsa-miR-20a-5p PLCB1 -0.179153323927949 0.928118119139752 0.585724538908979 0.503249899338964 miRNATAP -0.258542803923675 0.00213160010105103 NA NA NA hsa-miR-26a-1-3p PLCB1 -0.429875601809349 0.182136384322617 0.585724538908979 0.503249899338964 mirMAP -0.329886915019254 7.316451499044e-05 NA NA NA hsa-miR-26a-2-3p PLCB1 -0.427772454814258 0.28776911697575 0.585724538908979 0.503249899338964 mirMAP -0.242116000682071 0.00615186955400678 NA NA NA hsa-miR-338-5p PLCB1 0.484769112400393 0.393961930708873 0.585724538908979 0.503249899338964 PITA;mirMAP;miRNATAP -0.270578324175855 0.00012056197178218 NA NA NA hsa-miR-34a-5p PLCB1 -0.50188164870224 0.742034237185732 0.585724538908979 0.503249899338964 miRNATAP -0.291928197805485 0.00525758792989879 NA NA NA hsa-miR-590-3p PLCB1 -0.279244755376859 0.59126669933662 0.585724538908979 0.503249899338964 PITA;miRanda;mirMAP -0.293138422170019 0.000304208510341494 NA NA NA hsa-miR-590-5p PLCB1 -0.547819833829572 0.472735645776647 0.585724538908979 0.503249899338964 PITA;miRanda -0.271716680913537 0.00160597305679212 NA NA NA hsa-miR-93-5p PLCB1 -0.611073677204699 0.825297877093193 0.585724538908979 0.503249899338964 miRNATAP -0.393348618144292 0.000191048463479506 NA NA NA hsa-miR-26b-5p PLCB2 -0.0245931278499594 0.990377966314923 -0.322974746305648 0.684414890068434 miRNAWalker2_validate -0.310084346427735 0.00146917450043707 NA NA NA hsa-miR-339-5p PLCB2 -0.300425087100667 0.712912847076788 -0.322974746305648 0.684414890068434 miRanda -0.206136918352303 0.000544998799835996 NA NA NA hsa-let-7i-5p PLCB4 -0.200792135853451 0.922018647874073 0.174334761760549 0.909370618049436 miRNATAP -0.825858998532497 0.000326482119466754 NA NA NA hsa-miR-92a-3p PPARD 0.0278830870766349 0.993247426671713 0.104039944737684 0.939285686745944 miRNAWalker2_validate -0.146082897527087 0.0001877051160926 NA NA NA hsa-miR-143-5p PPP2CA 0.10589969923845 0.933358732923556 0.0356851568486913 0.982479603446852 MirTarget -0.113970843387226 3.04336029101809e-06 NA NA NA hsa-miR-30a-5p PPP2CA 0.219472325612346 0.933954023293816 0.0356851568486913 0.982479603446852 mirMAP -0.120297904871551 0.00285198820090026 NA NA NA hsa-miR-125a-5p PPP2R5C -0.00183986061615382 0.999158100170883 -0.0416764418339968 0.979060666938948 MirTarget;PITA;miRanda -0.128116734610181 0.000513753699682629 NA NA NA hsa-miR-132-3p PPP2R5C -0.244143673573889 0.871752726220643 -0.0416764418339968 0.979060666938948 miRNATAP -0.125263910265897 0.00408623818705044 NA NA NA hsa-miR-125a-5p PPP2R5E -0.00183986061615382 0.999158100170883 -0.315676038449801 0.782415509075426 miRNAWalker2_validate -0.206654538213536 2.85766790777101e-07 NA NA NA hsa-miR-130a-3p PPP2R5E 0.0910074087716906 0.929098200371948 -0.315676038449801 0.782415509075426 mirMAP -0.162786000810969 3.40039221813072e-07 NA NA NA hsa-miR-181a-5p PPP2R5E 0.0295101956318291 0.989325168350125 -0.315676038449801 0.782415509075426 MirTarget;mirMAP -0.127362411490184 0.000820389638518227 NA NA NA hsa-miR-181b-5p PPP2R5E 0.155313039554487 0.930176779696506 -0.315676038449801 0.782415509075426 MirTarget;mirMAP -0.119994528183826 0.00120115585852406 NA NA NA hsa-miR-199a-3p PPP2R5E 0.0782166873040424 0.973766909565326 -0.315676038449801 0.782415509075426 MirTarget;PITA -0.142900049123088 0.000138668354582098 NA NA NA hsa-miR-199b-3p PPP2R5E 0.0780653337513897 0.973815251150337 -0.315676038449801 0.782415509075426 MirTarget;PITA;miRNATAP -0.142871028193333 0.000139104402673137 NA NA NA hsa-miR-224-3p PPP2R5E 0.110372723153393 0.749091467231007 -0.315676038449801 0.782415509075426 mirMAP -0.106273069320977 1.89725476200205e-05 NA NA NA hsa-miR-23a-3p PPP2R5E -0.122198715333656 0.962717452143511 -0.315676038449801 0.782415509075426 MirTarget -0.278139919171475 1.27767565860005e-06 24997345 Downregulation of PPP2R5E expression by miR 23a suppresses apoptosis to facilitate the growth of gastric cancer cells; Here we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells; PPP2R5E is identified as a new target of miR-23a; Moreover overexpression of PPP2R5E reversed the negative effects of miR-23a; We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells gastric cancer hsa-miR-323a-3p PPP2R5E 0.279126405514894 0.478782330851768 -0.315676038449801 0.782415509075426 mirMAP -0.107447923933299 6.00091439116037e-05 NA NA NA hsa-miR-361-5p PPP2R5E -0.138735309928775 0.941495130308343 -0.315676038449801 0.782415509075426 miRanda -0.204044613003842 0.000116825054008582 NA NA NA hsa-miR-365a-3p PPP2R5E 0.0797451871548276 0.938758494058574 -0.315676038449801 0.782415509075426 miRNAWalker2_validate -0.11656185008126 0.00310912775237505 NA NA NA hsa-miR-374b-5p PPP2R5E -0.285682091626878 0.83569830479965 -0.315676038449801 0.782415509075426 mirMAP -0.151025762980418 0.000517777925342188 NA NA NA hsa-miR-17-5p PPP3CA -0.175448849583061 0.934544015912731 -0.087509752034574 0.946989676888573 miRNATAP -0.109137738299345 0.000214467204408686 NA NA NA hsa-miR-29a-5p PPP3CA -0.31835175571979 0.600442757817281 -0.087509752034574 0.946989676888573 mirMAP;miRNATAP -0.110664225522305 0.000326600214856183 NA NA NA hsa-miR-335-3p PPP3CA -0.244830745789445 0.88450019116631 -0.087509752034574 0.946989676888573 MirTarget -0.158993670541163 1.48991898684692e-07 NA NA NA hsa-miR-361-5p PPP3CA -0.138735309928775 0.941495130308343 -0.087509752034574 0.946989676888573 miRanda -0.181593940934707 0.00153602268336464 NA NA NA hsa-miR-374b-3p PPP3CA -0.0542885924440247 0.860753623992354 -0.087509752034574 0.946989676888573 MirTarget -0.118414724128426 0.00147351846810998 NA NA NA hsa-miR-361-5p PPP3CB -0.138735309928775 0.941495130308343 0.124829671662728 0.918408096293941 miRanda -0.192230575391786 6.63676765547426e-06 NA NA NA hsa-miR-421 PPP3CB -0.182032017078616 0.734704500318599 0.124829671662728 0.918408096293941 miRanda -0.101890409493066 2.52334802788457e-05 NA NA NA hsa-miR-375 PPP3CC -0.690952835064582 0.831716365337668 -0.156394846840244 0.838706340015868 miRanda -0.115145516987059 0.000311412501063658 NA NA NA hsa-miR-500a-3p PPP3CC -0.633375813338735 0.732582832733155 -0.156394846840244 0.838706340015868 MirTarget;miRNATAP -0.139392380696939 0.00623176129399307 NA NA NA hsa-miR-143-5p PPP3R1 0.10589969923845 0.933358732923556 -0.0496199114529308 0.972488514207793 miRNATAP -0.101757134766809 6.67106697655597e-08 NA NA NA hsa-miR-27b-3p PPP3R1 -0.14277121795778 0.951937409841932 -0.0496199114529308 0.972488514207793 miRNATAP -0.108860558741904 0.00403865953676784 NA NA NA hsa-miR-141-3p PRICKLE1 -0.31994058840327 0.87774106909065 0.397606853070468 0.442555940301968 TargetScan -0.818473615751552 9.37601439666738e-23 NA NA NA hsa-miR-17-5p PRICKLE1 -0.175448849583061 0.934544015912731 0.397606853070468 0.442555940301968 miRNAWalker2_validate -0.790549265744602 1.30087431373825e-19 NA NA NA hsa-miR-192-5p PRICKLE1 -0.117345487848223 0.972927287653137 0.397606853070468 0.442555940301968 miRNAWalker2_validate -0.64728705570708 8.41829279580836e-16 NA NA NA hsa-miR-215-5p PRICKLE1 -0.142648109361913 0.94480931294964 0.397606853070468 0.442555940301968 miRNAWalker2_validate -0.33329971176339 2.65696899946024e-10 NA NA NA hsa-miR-30b-5p PRICKLE1 -0.0121430518253582 0.994622896704513 0.397606853070468 0.442555940301968 mirMAP -0.69734076944353 7.36580665370513e-12 NA NA NA hsa-miR-30c-5p PRICKLE1 -0.298383882401475 0.865809030482001 0.397606853070468 0.442555940301968 miRNATAP -0.815096477914283 4.24777573380507e-08 NA NA NA hsa-miR-30d-5p PRICKLE1 -0.168211838771867 0.95173197030375 0.397606853070468 0.442555940301968 miRNATAP -0.507159229436342 0.000199081911275133 NA NA NA hsa-miR-532-5p PRICKLE1 -0.349665553500088 0.878948352437467 0.397606853070468 0.442555940301968 miRNATAP -0.54990543448667 2.0256078870021e-07 NA NA NA hsa-miR-582-5p PRICKLE1 -0.399450205475138 0.581227478860085 0.397606853070468 0.442555940301968 miRNATAP -0.691338431016561 1.10042354661321e-09 NA NA NA hsa-let-7a-3p PRICKLE2 -0.215598045625677 0.85543299203799 0.551121474925754 0.425361397476441 mirMAP -0.486808759656843 6.22651748439903e-08 NA NA NA hsa-let-7f-1-3p PRICKLE2 -0.31101436822914 0.693407210545374 0.551121474925754 0.425361397476441 mirMAP -0.649917154187097 1.26646256542526e-07 NA NA NA hsa-let-7f-2-3p PRICKLE2 -0.0455032713433074 0.882115725419367 0.551121474925754 0.425361397476441 mirMAP -0.319627545149741 6.13882058950175e-06 NA NA NA hsa-miR-130b-5p PRICKLE2 -0.6472141103776 0.379096015222509 0.551121474925754 0.425361397476441 mirMAP -0.588881791025954 1.0028067128924e-14 NA NA NA hsa-miR-146a-5p PRICKLE2 -0.581292803346906 0.73685134936757 0.551121474925754 0.425361397476441 mirMAP -0.365062064665585 1.02874914577729e-07 NA NA NA hsa-miR-148a-3p PRICKLE2 -0.101286586375016 0.976980454193186 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.544673899928546 3.25913699860419e-11 NA NA NA hsa-miR-148a-5p PRICKLE2 -0.448099743845604 0.748419139652266 0.551121474925754 0.425361397476441 mirMAP -0.499070979600238 3.70537808988988e-10 NA NA NA hsa-miR-148b-3p PRICKLE2 -0.202106692287125 0.911884960581838 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.704296098796368 2.01607240594954e-09 NA NA NA hsa-miR-15b-3p PRICKLE2 -0.557749208157585 0.609181305423188 0.551121474925754 0.425361397476441 mirMAP -0.688292316856109 4.77438091036482e-18 NA NA NA hsa-miR-16-2-3p PRICKLE2 -0.36717860153421 0.546850726070016 0.551121474925754 0.425361397476441 mirMAP -0.616352235508973 3.35701580033797e-18 NA NA NA hsa-miR-182-5p PRICKLE2 -0.104238497940557 0.973380614062243 0.551121474925754 0.425361397476441 MirTarget -0.285650293085441 8.55519769941171e-05 NA NA NA hsa-miR-186-5p PRICKLE2 -0.318786974828757 0.85412722938961 0.551121474925754 0.425361397476441 MirTarget -0.760915875673251 1.07298702005099e-11 NA NA NA hsa-miR-18a-5p PRICKLE2 -0.498318455303917 0.61264091975585 0.551121474925754 0.425361397476441 MirTarget -0.383628672906702 5.72043737622555e-11 NA NA NA hsa-miR-18b-5p PRICKLE2 -0.0473300652227538 0.899981261531446 0.551121474925754 0.425361397476441 MirTarget -0.364072816443201 2.47026671417851e-10 NA NA NA hsa-miR-194-5p PRICKLE2 -0.159001168846464 0.959682382557336 0.551121474925754 0.425361397476441 miRNATAP -0.509079675776611 2.8161487802942e-12 NA NA NA hsa-miR-197-3p PRICKLE2 -0.455489147957159 0.794916582095149 0.551121474925754 0.425361397476441 mirMAP -0.49406964650522 1.99183781196082e-08 NA NA NA hsa-miR-19a-3p PRICKLE2 -0.206793507801887 0.844637784802316 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.467250853654183 1.49129438910777e-12 NA NA NA hsa-miR-19b-3p PRICKLE2 -0.0268530183621474 0.986656783046572 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.517502462903555 8.32610310004983e-11 NA NA NA hsa-miR-203a-3p PRICKLE2 -0.265248086637561 0.931593594361942 0.551121474925754 0.425361397476441 MirTarget -0.316999347856671 1.70155742833056e-07 NA NA NA hsa-miR-221-5p PRICKLE2 0.0797468413208215 0.897597103192104 0.551121474925754 0.425361397476441 MirTarget -0.25473581546081 2.92855583247191e-05 NA NA NA hsa-miR-26a-1-3p PRICKLE2 -0.429875601809349 0.182136384322617 0.551121474925754 0.425361397476441 mirMAP -0.398447767042993 9.44641783902884e-09 NA NA NA hsa-miR-26a-2-3p PRICKLE2 -0.427772454814258 0.28776911697575 0.551121474925754 0.425361397476441 mirMAP -0.440107836306688 1.46362629232305e-09 NA NA NA hsa-miR-27a-3p PRICKLE2 -0.123902317731458 0.958804393510999 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.58545033760497 8.42467607206818e-06 NA NA NA hsa-miR-29a-3p PRICKLE2 0.01127474410284 0.996977020481272 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.637855836581901 1.69882909943348e-09 NA NA NA hsa-miR-29b-3p PRICKLE2 -0.104016192263954 0.958988036765397 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.560356525121839 1.26483864449025e-12 NA NA NA hsa-miR-32-3p PRICKLE2 -0.568003960723004 0.13133163420273 0.551121474925754 0.425361397476441 MirTarget;mirMAP -0.448590379297521 2.32102115207005e-15 NA NA NA hsa-miR-320a PRICKLE2 -0.416546433767628 0.840202138616422 0.551121474925754 0.425361397476441 mirMAP -0.277014228434591 0.00522473269161862 NA NA NA hsa-miR-320b PRICKLE2 -0.23561798088153 0.859222532827992 0.551121474925754 0.425361397476441 mirMAP -0.246688735696225 0.00561544591888516 NA NA NA hsa-miR-320c PRICKLE2 -0.577462251570141 0.113597318870228 0.551121474925754 0.425361397476441 mirMAP -0.187541898917261 0.00438167568957247 NA NA NA hsa-miR-330-5p PRICKLE2 -0.283418953659271 0.815687101334695 0.551121474925754 0.425361397476441 miRanda;miRNATAP -0.294120638906423 0.00702002406370247 NA NA NA hsa-miR-335-3p PRICKLE2 -0.244830745789445 0.88450019116631 0.551121474925754 0.425361397476441 mirMAP -0.327998824549096 1.20869879805509e-05 NA NA NA hsa-miR-335-5p PRICKLE2 -0.0284895175847679 0.973380867832231 0.551121474925754 0.425361397476441 miRNAWalker2_validate -0.411380851679834 3.07454584358168e-08 NA NA NA hsa-miR-33a-3p PRICKLE2 -0.794543849238581 0.0105203072007922 0.551121474925754 0.425361397476441 mirMAP -0.383579402443222 2.26971748158838e-08 NA NA NA hsa-miR-33a-5p PRICKLE2 -0.205788753603336 0.853314500865147 0.551121474925754 0.425361397476441 MirTarget -0.316072164368108 1.29606125417615e-13 NA NA NA hsa-miR-33b-5p PRICKLE2 -0.161971614375297 0.737436207821109 0.551121474925754 0.425361397476441 MirTarget -0.346959554400778 2.35287835853317e-13 NA NA NA hsa-miR-361-5p PRICKLE2 -0.138735309928775 0.941495130308343 0.551121474925754 0.425361397476441 MirTarget;PITA;miRanda;miRNATAP -0.391181201112103 0.00553598024525293 NA NA NA hsa-miR-362-5p PRICKLE2 -0.26647467080141 0.752024885130738 0.551121474925754 0.425361397476441 mirMAP -0.383170665620435 7.18994745741999e-10 NA NA NA hsa-miR-374a-3p PRICKLE2 -0.118320910531011 0.958176637009264 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.256520122440454 0.00201236442698444 NA NA NA hsa-miR-421 PRICKLE2 -0.182032017078616 0.734704500318599 0.551121474925754 0.425361397476441 miRanda -0.258468150256993 0.00113919360267716 NA NA NA hsa-miR-429 PRICKLE2 -0.456485631615963 0.806240953400535 0.551121474925754 0.425361397476441 miRNATAP -0.468418045864181 5.59928416088308e-14 NA NA NA hsa-miR-484 PRICKLE2 -0.179977202691249 0.886333755572375 0.551121474925754 0.425361397476441 miRNATAP -0.603301359999593 2.17957059056441e-09 NA NA NA hsa-miR-491-3p PRICKLE2 -0.513850326596847 0.137836285146052 0.551121474925754 0.425361397476441 MirTarget;PITA;miRNATAP -0.222924967408406 0.00134478154580176 NA NA NA hsa-miR-500a-5p PRICKLE2 -0.71978560736831 0.188073776225276 0.551121474925754 0.425361397476441 mirMAP -0.402917168509734 5.42822139945647e-09 NA NA NA hsa-miR-576-5p PRICKLE2 -0.506413219377403 0.417187951364173 0.551121474925754 0.425361397476441 mirMAP -0.610413958049022 8.31494917073662e-15 NA NA NA hsa-miR-589-3p PRICKLE2 -0.835836305204965 0.0112001563801511 0.551121474925754 0.425361397476441 MirTarget -0.330853616588062 1.71172483697326e-07 NA NA NA hsa-miR-589-5p PRICKLE2 -0.448771545046784 0.722725226273464 0.551121474925754 0.425361397476441 MirTarget;miRNATAP -0.786133046889626 5.16341882659806e-13 NA NA NA hsa-miR-590-3p PRICKLE2 -0.279244755376859 0.59126669933662 0.551121474925754 0.425361397476441 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.599810712303541 3.51870552280468e-21 NA NA NA hsa-miR-590-5p PRICKLE2 -0.547819833829572 0.472735645776647 0.551121474925754 0.425361397476441 MirTarget;PITA;miRanda -0.616868974762062 6.88998403289716e-20 NA NA NA hsa-miR-624-5p PRICKLE2 -0.348001560408561 0.190596385087429 0.551121474925754 0.425361397476441 mirMAP -0.425462959618979 1.85417661270223e-07 NA NA NA hsa-miR-629-3p PRICKLE2 -0.495402745812008 0.333967382214384 0.551121474925754 0.425361397476441 MirTarget -0.469257692569965 1.31202880017108e-13 NA NA NA hsa-miR-7-1-3p PRICKLE2 -0.462485777435991 0.665899751398166 0.551121474925754 0.425361397476441 MirTarget -0.636650559798631 5.10896150513941e-17 NA NA NA hsa-miR-126-5p PRKACB 0.0815213541035824 0.956637332055185 0.143826955266481 0.908097519021419 mirMAP -0.368751851213397 0.00120348231579359 NA NA NA hsa-miR-146b-5p PRKACB -0.402662509440887 0.837510937985091 0.143826955266481 0.908097519021419 miRanda -0.384839282045274 0.000123624033577825 NA NA NA hsa-miR-16-2-3p PRKACB -0.36717860153421 0.546850726070016 0.143826955266481 0.908097519021419 mirMAP -0.327254668787011 5.02396526650647e-05 NA NA NA hsa-miR-18a-5p PRKACB -0.498318455303917 0.61264091975585 0.143826955266481 0.908097519021419 miRNATAP -0.245987058818593 0.000136929122339416 NA NA NA hsa-miR-18b-5p PRKACB -0.0473300652227538 0.899981261531446 0.143826955266481 0.908097519021419 miRNATAP -0.219595347623136 0.000526621294339559 NA NA NA hsa-miR-19a-3p PRKACB -0.206793507801887 0.844637784802316 0.143826955266481 0.908097519021419 MirTarget;miRNATAP -0.207051001728292 0.00506627328237604 NA NA NA hsa-miR-32-3p PRKACB -0.568003960723004 0.13133163420273 0.143826955266481 0.908097519021419 mirMAP;miRNATAP -0.203540155235648 0.00148647674126439 NA NA NA hsa-miR-577 PRKACB -1.06238199218774 0.326056761787754 0.143826955266481 0.908097519021419 PITA -0.156719343600752 0.000649809465517546 NA NA NA hsa-miR-582-5p PRKACB -0.399450205475138 0.581227478860085 0.143826955266481 0.908097519021419 MirTarget;PITA;miRNATAP -0.435642871850008 4.26493780643228e-06 NA NA NA hsa-miR-590-3p PRKACB -0.279244755376859 0.59126669933662 0.143826955266481 0.908097519021419 MirTarget;PITA;miRanda;miRNATAP -0.287824756359109 8.97202997356946e-05 NA NA NA hsa-miR-590-5p PRKACB -0.547819833829572 0.472735645776647 0.143826955266481 0.908097519021419 miRanda -0.269757804036837 0.000543621862271192 NA NA NA hsa-miR-7-1-3p PRKACB -0.462485777435991 0.665899751398166 0.143826955266481 0.908097519021419 mirMAP -0.347600791347028 5.3123112509601e-05 NA NA NA hsa-miR-29a-5p PRKCA -0.31835175571979 0.600442757817281 0.0560239871270882 0.96439442241644 mirMAP -0.131495002018621 0.00519611005738431 NA NA NA hsa-miR-450b-5p PRKCA -0.0136687538973108 0.983149761399849 0.0560239871270882 0.96439442241644 PITA;mirMAP;miRNATAP -0.165403673620787 0.00202940790109251 NA NA NA hsa-miR-141-5p PRKCB -0.354590233549885 0.867642456336402 -0.289166762598654 0.629896233011357 mirMAP -0.566149586465332 2.81537724392599e-08 NA NA NA hsa-miR-148a-5p PRKCB -0.448099743845604 0.748419139652266 -0.289166762598654 0.629896233011357 mirMAP -0.431607663118204 0.00014113366592115 NA NA NA hsa-miR-16-2-3p PRKCB -0.36717860153421 0.546850726070016 -0.289166762598654 0.629896233011357 mirMAP -0.556524355024035 7.09185137143842e-08 NA NA NA hsa-miR-186-5p PRKCB -0.318786974828757 0.85412722938961 -0.289166762598654 0.629896233011357 mirMAP -0.693684359345577 1.42561623028323e-05 NA NA NA hsa-miR-194-5p PRKCB -0.159001168846464 0.959682382557336 -0.289166762598654 0.629896233011357 miRNATAP -0.642313551381144 2.93325886945843e-10 NA NA NA hsa-miR-200b-3p PRKCB -0.426401948379212 0.863957108574195 -0.289166762598654 0.629896233011357 MirTarget -0.72108199701521 2.3659342346039e-11 NA NA NA hsa-miR-200c-3p PRKCB -0.437282635857873 0.887118598436407 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.752138899288806 1.18209268005294e-11 NA NA NA hsa-miR-23a-3p PRKCB -0.122198715333656 0.962717452143511 -0.289166762598654 0.629896233011357 mirMAP -0.972693790442231 3.83115244358293e-06 NA NA NA hsa-miR-24-3p PRKCB -0.0484778924256624 0.985274054814493 -0.289166762598654 0.629896233011357 miRNATAP -1.14917640884554 4.29809672564759e-07 NA NA NA hsa-miR-26b-5p PRKCB -0.0245931278499594 0.990377966314923 -0.289166762598654 0.629896233011357 mirMAP -0.759590158099125 4.96577614466636e-07 NA NA NA hsa-miR-27a-3p PRKCB -0.123902317731458 0.958804393510999 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.984191959979311 4.52942226692975e-08 NA NA NA hsa-miR-29a-5p PRKCB -0.31835175571979 0.600442757817281 -0.289166762598654 0.629896233011357 mirMAP -0.696324093556409 4.49269492269061e-12 NA NA NA hsa-miR-29b-1-5p PRKCB -0.642348119412534 0.293891497238796 -0.289166762598654 0.629896233011357 mirMAP -0.462740943974498 6.40796306307966e-09 NA NA NA hsa-miR-30b-5p PRKCB -0.0121430518253582 0.994622896704513 -0.289166762598654 0.629896233011357 mirMAP -0.662037641995433 1.55759802125021e-09 NA NA NA hsa-miR-30c-5p PRKCB -0.298383882401475 0.865809030482001 -0.289166762598654 0.629896233011357 mirMAP -0.651180444056476 5.12606576516922e-05 NA NA NA hsa-miR-30d-3p PRKCB -0.123474741320298 0.814905367625791 -0.289166762598654 0.629896233011357 mirMAP -0.66303716180293 1.26976276659109e-07 NA NA NA hsa-miR-30d-5p PRKCB -0.168211838771867 0.95173197030375 -0.289166762598654 0.629896233011357 mirMAP -0.584797855466169 5.33137646933608e-05 NA NA NA hsa-miR-335-3p PRKCB -0.244830745789445 0.88450019116631 -0.289166762598654 0.629896233011357 mirMAP -0.677283755988629 1.84838818790619e-11 NA NA NA hsa-miR-335-5p PRKCB -0.0284895175847679 0.973380867832231 -0.289166762598654 0.629896233011357 mirMAP -0.675730225781425 2.5572319841088e-11 NA NA NA hsa-miR-361-5p PRKCB -0.138735309928775 0.941495130308343 -0.289166762598654 0.629896233011357 MirTarget;miRanda;miRNATAP -0.865758986282353 6.88790498193778e-06 NA NA NA hsa-miR-429 PRKCB -0.456485631615963 0.806240953400535 -0.289166762598654 0.629896233011357 MirTarget;miRanda;miRNATAP -0.619682801567495 9.47055177854519e-13 NA NA NA hsa-miR-450b-5p PRKCB -0.0136687538973108 0.983149761399849 -0.289166762598654 0.629896233011357 miRNATAP -0.47287159382327 7.10615810748377e-05 NA NA NA hsa-miR-452-3p PRKCB -0.167134177977311 0.799008246175244 -0.289166762598654 0.629896233011357 mirMAP -0.513101429149364 6.7170941174423e-11 NA NA NA hsa-miR-484 PRKCB -0.179977202691249 0.886333755572375 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.612122177986842 1.70623299361676e-05 NA NA NA hsa-miR-491-5p PRKCB -0.585652105321328 0.0452620602586908 -0.289166762598654 0.629896233011357 miRanda -0.35090662989035 0.000620664439809745 NA NA NA hsa-miR-502-5p PRKCB -0.708507838520586 0.0261309781860104 -0.289166762598654 0.629896233011357 mirMAP -0.435593863435658 2.75280823982211e-06 NA NA NA hsa-miR-539-5p PRKCB 0.124342970087029 0.801067485473643 -0.289166762598654 0.629896233011357 mirMAP -0.432505044940763 0.00059746887984469 NA NA NA hsa-miR-589-3p PRKCB -0.835836305204965 0.0112001563801511 -0.289166762598654 0.629896233011357 mirMAP -0.335038959210738 0.00016508749914759 NA NA NA hsa-miR-589-5p PRKCB -0.448771545046784 0.722725226273464 -0.289166762598654 0.629896233011357 mirMAP -0.565653175638186 0.000328937511746594 NA NA NA hsa-miR-590-3p PRKCB -0.279244755376859 0.59126669933662 -0.289166762598654 0.629896233011357 mirMAP -0.422590592433378 8.43504361358025e-06 NA NA NA hsa-miR-590-5p PRKCB -0.547819833829572 0.472735645776647 -0.289166762598654 0.629896233011357 miRanda -0.600413375866668 1.04790649499024e-09 NA NA NA hsa-miR-7-1-3p PRKCB -0.462485777435991 0.665899751398166 -0.289166762598654 0.629896233011357 mirMAP -0.417430474142834 0.000191851900734184 NA NA NA hsa-miR-7-5p PRKCB 0.209645143210379 0.773705612298441 -0.289166762598654 0.629896233011357 MirTarget;miRNATAP -0.205730135642304 0.0042868075722764 NA NA NA hsa-miR-361-5p PSEN1 -0.138735309928775 0.941495130308343 0.0284597443792265 0.985193872161012 miRanda -0.148443410758776 0.00109359287287113 NA NA NA hsa-miR-30c-2-3p RAC3 0.242912714924037 0.746927269997556 -0.189305936526801 0.723079466838889 miRNAWalker2_validate -0.284587404659289 0.00785701503311612 NA NA NA hsa-miR-361-5p RHOA -0.138735309928775 0.941495130308343 -0.17248196974016 0.934600726677384 MirTarget;PITA;miRanda -0.125411234757926 0.000736149169851785 NA NA NA hsa-let-7a-3p ROCK1 -0.215598045625677 0.85543299203799 -0.160229804897247 0.900120450768099 MirTarget -0.109897922952036 0.00727315012848761 NA NA NA hsa-miR-126-5p ROCK1 0.0815213541035824 0.956637332055185 -0.160229804897247 0.900120450768099 mirMAP -0.126374783815714 0.00789684731732039 27108693 MicroRNA 126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma metastasis kidney renal cell cancer hsa-miR-196b-5p ROCK1 -0.0840912027031901 0.972112413910242 -0.160229804897247 0.900120450768099 MirTarget -0.105486954228359 4.82675478576074e-07 NA NA NA hsa-miR-199b-5p ROCK1 -0.0396557270992508 0.977172718873203 -0.160229804897247 0.900120450768099 miRanda -0.106455048638711 0.00285421904884719 NA NA NA hsa-miR-335-5p ROCK1 -0.0284895175847679 0.973380867832231 -0.160229804897247 0.900120450768099 MirTarget -0.173047170326878 1.72899440825558e-07 25804796;23975506;27035227 MiR 335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma; Luciferase reporter assay and Western blot were to verify ROCK1 as a novel target gene of miR-335; The expression of ROCK1 was decreased evidently after overexpression of miR-335 indicating that ROCK1 is a target gene for miR-335; Our data revealed that miR-335 could inhibit the proliferation and migration invasion of HCC cells via regulating ROCK1 suggesting that miR-335 could be a therapeutic biomarker of HCC in the future;miR 335 suppresses migration and invasion by targeting ROCK1 in osteosarcoma cells; Moreover we also showed that ROCK1 was negatively regulated by miR-335 at the posttranscriptional level via a specific target site within the 3'UTR by luciferase reporter assay; Thus our findings suggest that miR-335 acts as tumor suppressor by targeting the ROCK1 gene and inhibiting osteosarcoma cells migration and invasion;MicroRNA 335 is downregulated in bladder cancer and inhibits cell growth migration and invasion via targeting ROCK1 ;; liver cancer;sarcoma;bladder cancer hsa-miR-421 ROCK1 -0.182032017078616 0.734704500318599 -0.160229804897247 0.900120450768099 PITA;miRanda -0.116931197362984 0.000910505996090609 NA NA NA hsa-miR-126-5p ROCK2 0.0815213541035824 0.956637332055185 -0.0784931116538807 0.956633941372985 mirMAP -0.248685955442308 1.89704870838048e-05 NA NA NA hsa-miR-142-3p ROCK2 -0.154235241441331 0.946098054588918 -0.0784931116538807 0.956633941372985 PITA;miRanda;miRNATAP -0.125681145854652 0.000740862230337074 NA NA NA hsa-miR-142-5p ROCK2 -0.118920788314118 0.929665277963083 -0.0784931116538807 0.956633941372985 PITA -0.230070984478962 9.16968002632336e-09 NA NA NA hsa-miR-340-5p ROCK2 -0.00276909425328853 0.99757361161055 -0.0784931116538807 0.956633941372985 mirMAP -0.163993581104367 0.00216910718049147 NA NA NA hsa-miR-369-3p ROCK2 0.116576891957687 0.83230082995912 -0.0784931116538807 0.956633941372985 PITA -0.159509994745788 0.000626162192050428 NA NA NA hsa-miR-582-5p ROCK2 -0.399450205475138 0.581227478860085 -0.0784931116538807 0.956633941372985 mirMAP -0.226167385479782 3.55837392122283e-06 NA NA NA hsa-miR-590-3p ROCK2 -0.279244755376859 0.59126669933662 -0.0784931116538807 0.956633941372985 miRanda;mirMAP -0.110309753505061 0.00384013133160484 NA NA NA hsa-miR-140-3p SENP2 -0.369894078407761 0.864762211761539 -0.0110860053375177 0.992309888458903 mirMAP -0.103841821484027 0.00988974207295154 NA NA NA hsa-miR-1275 SFRP1 -0.831342050607648 0.0803795852164229 0.458789669044077 0.49771307771223 MirTarget -0.510540537016915 4.91642034813301e-06 NA NA NA hsa-miR-1301-3p SFRP1 -0.300365313996304 0.592260761856533 0.458789669044077 0.49771307771223 MirTarget -0.497713364758576 0.00735480617827187 NA NA NA hsa-miR-144-3p SFRP1 0.0482420655617901 0.935871997593533 0.458789669044077 0.49771307771223 MirTarget;miRNATAP -0.358423128968886 0.00103309540082995 NA NA NA hsa-miR-146a-5p SFRP1 -0.581292803346906 0.73685134936757 0.458789669044077 0.49771307771223 MirTarget -0.846143779831789 1.01575031051527e-08 NA NA NA hsa-miR-16-1-3p SFRP1 0.151694812889216 0.733736501874638 0.458789669044077 0.49771307771223 MirTarget -0.94903091584512 5.95946084903295e-10 NA NA NA hsa-miR-182-5p SFRP1 -0.104238497940557 0.973380614062243 0.458789669044077 0.49771307771223 mirMAP -0.932291865465018 1.2943599236268e-09 NA NA NA hsa-miR-192-3p SFRP1 -0.182835023264086 0.910241598161436 0.458789669044077 0.49771307771223 MirTarget -0.975123825878634 1.08283373363427e-10 NA NA NA hsa-miR-19b-1-5p SFRP1 -0.0105982583216702 0.988511655226679 0.458789669044077 0.49771307771223 MirTarget -0.919889537334065 1.25932051593181e-08 NA NA NA hsa-miR-203a-3p SFRP1 -0.265248086637561 0.931593594361942 0.458789669044077 0.49771307771223 MirTarget -0.81768716061472 2.59763257790948e-10 NA NA NA hsa-miR-26b-3p SFRP1 -0.363222538866814 0.681115126930068 0.458789669044077 0.49771307771223 MirTarget -1.17440791330659 5.91867020797149e-11 NA NA NA hsa-miR-27a-3p SFRP1 -0.123902317731458 0.958804393510999 0.458789669044077 0.49771307771223 MirTarget;miRNATAP -1.43168422415878 4.06049988636225e-07 NA NA NA hsa-miR-27b-3p SFRP1 -0.14277121795778 0.951937409841932 0.458789669044077 0.49771307771223 MirTarget;miRNATAP -0.929865113415932 0.00501191857774073 NA NA NA hsa-miR-29a-5p SFRP1 -0.31835175571979 0.600442757817281 0.458789669044077 0.49771307771223 mirMAP -1.01562407123408 1.45195577156907e-10 NA NA NA hsa-miR-30d-3p SFRP1 -0.123474741320298 0.814905367625791 0.458789669044077 0.49771307771223 miRNATAP -1.32115521540396 5.8583684537136e-12 NA NA NA hsa-miR-335-5p SFRP1 -0.0284895175847679 0.973380867832231 0.458789669044077 0.49771307771223 miRNAWalker2_validate -0.892731717727035 2.80128298274367e-08 NA NA NA hsa-miR-33a-3p SFRP1 -0.794543849238581 0.0105203072007922 0.458789669044077 0.49771307771223 MirTarget -0.858662492456339 6.73104764910375e-09 NA NA NA hsa-miR-429 SFRP1 -0.456485631615963 0.806240953400535 0.458789669044077 0.49771307771223 miRNATAP -1.24663052326811 7.35155412645914e-22 NA NA NA hsa-miR-484 SFRP1 -0.179977202691249 0.886333755572375 0.458789669044077 0.49771307771223 MirTarget -1.27634670225105 5.27114225673435e-09 NA NA NA hsa-miR-501-5p SFRP1 -0.834032628506285 0.0582725160418523 0.458789669044077 0.49771307771223 mirMAP -0.545969812548283 3.76450866815485e-05 NA NA NA hsa-miR-576-5p SFRP1 -0.506413219377403 0.417187951364173 0.458789669044077 0.49771307771223 MirTarget;PITA -1.28654170293773 5.0453153375364e-14 NA NA NA hsa-miR-625-5p SFRP1 -0.690759472145277 0.210306534567564 0.458789669044077 0.49771307771223 MirTarget -0.782794611180533 9.22876635361979e-10 NA NA NA hsa-miR-7-1-3p SFRP1 -0.462485777435991 0.665899751398166 0.458789669044077 0.49771307771223 MirTarget;mirMAP -1.12372798591865 3.02871534285669e-11 NA NA NA hsa-miR-940 SFRP1 -0.225788347550697 0.680055767105815 0.458789669044077 0.49771307771223 MirTarget -0.588765920767129 3.46674850275754e-06 NA NA NA hsa-miR-96-5p SFRP1 0.0854810872029343 0.923087820185031 0.458789669044077 0.49771307771223 mirMAP -1.25488507498404 1.73939520013468e-18 NA NA NA hsa-let-7a-3p SFRP2 -0.215598045625677 0.85543299203799 0.828426942621678 0.52597578513785 miRNATAP -1.19419982770431 8.44331763953112e-07 NA NA NA hsa-miR-29a-3p SFRP2 0.01127474410284 0.996977020481272 0.828426942621678 0.52597578513785 miRNAWalker2_validate;miRTarBase -1.34651262952855 3.04708226426706e-06 NA NA NA hsa-miR-33a-3p SFRP2 -0.794543849238581 0.0105203072007922 0.828426942621678 0.52597578513785 miRNATAP -1.11979657385788 8.73863133317584e-10 NA NA NA hsa-miR-421 SFRP2 -0.182032017078616 0.734704500318599 0.828426942621678 0.52597578513785 miRanda -1.1574489514346 2.67789668864241e-08 NA NA NA hsa-miR-582-5p SFRP2 -0.399450205475138 0.581227478860085 0.828426942621678 0.52597578513785 miRNATAP -0.794718546768346 0.000966109549341752 NA NA NA hsa-miR-590-3p SFRP2 -0.279244755376859 0.59126669933662 0.828426942621678 0.52597578513785 miRanda -1.15812236502637 1.03785390945399e-10 NA NA NA hsa-miR-135b-5p SFRP4 0.631573976263484 0.610028066417462 0.570054637700394 0.641396949001081 MirTarget -0.429968210947886 0.000199377398735162 NA NA NA hsa-miR-144-5p SFRP4 -0.300173463942009 0.809668168233345 0.570054637700394 0.641396949001081 MirTarget -0.712797348021187 4.20840018189014e-08 NA NA NA hsa-miR-26b-5p SFRP4 -0.0245931278499594 0.990377966314923 0.570054637700394 0.641396949001081 miRNAWalker2_validate -1.48894213531648 1.65295312706766e-09 NA NA NA hsa-miR-375 SFRP4 -0.690952835064582 0.831716365337668 0.570054637700394 0.641396949001081 miRanda -0.77349034068892 2.67562707158269e-11 NA NA NA hsa-miR-429 SFRP4 -0.456485631615963 0.806240953400535 0.570054637700394 0.641396949001081 miRanda -1.14750864069437 4.73695906161965e-16 NA NA NA hsa-miR-532-5p SFRP4 -0.349665553500088 0.878948352437467 0.570054637700394 0.641396949001081 MirTarget -0.731145221840523 0.000109421545082678 NA NA NA hsa-miR-1254 SFRP5 -0.488929355953681 0.19551794273322 1.22233307700635 0.234281949494886 MirTarget -0.393887940236465 0.00308971845750956 NA NA NA hsa-miR-146b-5p SFRP5 -0.402662509440887 0.837510937985091 1.22233307700635 0.234281949494886 miRanda -0.768326128980126 4.78267828546294e-05 NA NA NA hsa-miR-142-3p SIAH1 -0.154235241441331 0.946098054588918 0.054033606017696 0.961532813193172 miRanda -0.10765334580304 3.68881036481584e-07 NA NA NA hsa-miR-130a-3p SKP1 0.0910074087716906 0.929098200371948 0.0785624221664962 0.964224893360423 MirTarget -0.108880313437338 0.000189665521401675 NA NA NA hsa-miR-152-3p SKP1 0.203532896690202 0.90975730233375 0.0785624221664962 0.964224893360423 MirTarget -0.149618810294814 0.00237149821646277 NA NA NA hsa-miR-224-5p SMAD2 -0.240425158977724 0.857351098476517 -0.341385137878995 0.80352777577035 mirMAP -0.144946896100267 2.28330730309658e-06 NA NA NA hsa-miR-335-3p SMAD2 -0.244830745789445 0.88450019116631 -0.341385137878995 0.80352777577035 mirMAP -0.183748416593897 1.45959723247652e-06 NA NA NA hsa-miR-361-5p SMAD2 -0.138735309928775 0.941495130308343 -0.341385137878995 0.80352777577035 MirTarget -0.259356843450004 0.000295254093149791 NA NA NA hsa-miR-362-5p SMAD2 -0.26647467080141 0.752024885130738 -0.341385137878995 0.80352777577035 mirMAP -0.136859171316736 2.57672906518625e-05 NA NA NA hsa-miR-374a-5p SMAD2 -0.343007247142618 0.766921280269271 -0.341385137878995 0.80352777577035 MirTarget -0.253649660447609 2.52056689655766e-05 NA NA NA hsa-miR-374b-5p SMAD2 -0.285682091626878 0.83569830479965 -0.341385137878995 0.80352777577035 MirTarget -0.229429865423688 8.85252457736708e-05 NA NA NA hsa-miR-421 SMAD2 -0.182032017078616 0.734704500318599 -0.341385137878995 0.80352777577035 miRanda -0.145020546518494 0.000344143197074529 NA NA NA hsa-miR-532-5p SMAD2 -0.349665553500088 0.878948352437467 -0.341385137878995 0.80352777577035 MirTarget -0.161763384526726 0.000125286468937968 NA NA NA hsa-miR-106a-5p SMAD4 -0.203919267842652 0.802213958426804 -0.473107439957935 0.714784528258547 mirMAP;miRNATAP -0.131559182838557 0.00285404554218347 NA NA NA hsa-miR-126-5p SMAD4 0.0815213541035824 0.956637332055185 -0.473107439957935 0.714784528258547 mirMAP -0.17020815706545 0.00292610435147629 NA NA NA hsa-miR-130a-3p SMAD4 0.0910074087716906 0.929098200371948 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;miRNATAP -0.184401339431379 5.24541105443445e-05 NA NA NA hsa-miR-17-5p SMAD4 -0.175448849583061 0.934544015912731 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.156039110852489 5.25398949950574e-05 NA NA NA hsa-miR-188-5p SMAD4 -0.568517670542551 0.324820848307954 -0.473107439957935 0.714784528258547 mirMAP -0.155102827964383 1.62558980704385e-06 NA NA NA hsa-miR-18a-5p SMAD4 -0.498318455303917 0.61264091975585 -0.473107439957935 0.714784528258547 miRNAWalker2_validate -0.114726944873734 0.000401136839426702 NA NA NA hsa-miR-19a-3p SMAD4 -0.206793507801887 0.844637784802316 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.128678500941526 0.000480832222870715 NA NA NA hsa-miR-19b-1-5p SMAD4 -0.0105982583216702 0.988511655226679 -0.473107439957935 0.714784528258547 mirMAP -0.114973355211667 0.00512532740693421 NA NA NA hsa-miR-19b-3p SMAD4 -0.0268530183621474 0.986656783046572 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;mirMAP;miRNATAP -0.168993961293221 0.000120795994186259 NA NA NA hsa-miR-20a-3p SMAD4 0.456808229166028 0.57674056136504 -0.473107439957935 0.714784528258547 mirMAP -0.10577777067313 0.000632028096974473 27286257 MicroRNA 20a 5p promotes colorectal cancer invasion and metastasis by downregulating Smad4 metastasis colorectal cancer hsa-miR-20a-5p SMAD4 -0.179153323927949 0.928118119139752 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;mirMAP;miRNATAP -0.135068597650963 0.000403680215106847 27286257 MicroRNA 20a 5p promotes colorectal cancer invasion and metastasis by downregulating Smad4; miR-20a-5p negatively regulated Smad4 by directly targeting its 3'UTR in human colorectal cancer cells; miR-20a-5p not only promoted CRC cells aggression capacity in vitro and liver metastasis in vivo but also promoted the epithelial-to-mesenchymal transition process by downregulating Smad4 expression; Luciferase reporter assay and transfection technique were used to validate the correlation between miR-20a-5p and Smad4 in CRC; Wound healing transwell and tumorigenesis assays were used to explore the function of miR-20a-5p and Smad4 in CRC progression in vitro and in vivo; miR-20a-5p as an onco-miRNA promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells and high miR-20a-5p predicted poor prognosis for CRC patients providing a novel and promising therapeutic target in human colorectal cancer metastasis;progression;tumorigenesis;worse prognosis colorectal cancer hsa-miR-214-5p SMAD4 0.056229650193357 0.945594330093021 -0.473107439957935 0.714784528258547 MirTarget -0.147056148842957 0.000874920355644155 NA NA NA hsa-miR-224-3p SMAD4 0.110372723153393 0.749091467231007 -0.473107439957935 0.714784528258547 mirMAP -0.15203159741221 1.47510559860259e-05 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-224-5p SMAD4 -0.240425158977724 0.857351098476517 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;miRTarBase;MirTarget -0.161750410504916 4.20843705349202e-07 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-30c-5p SMAD4 -0.298383882401475 0.865809030482001 -0.473107439957935 0.714784528258547 mirMAP -0.161864241902982 0.00997017208528321 NA NA NA hsa-miR-335-3p SMAD4 -0.244830745789445 0.88450019116631 -0.473107439957935 0.714784528258547 mirMAP -0.152108913902534 0.000161782003808618 NA NA NA hsa-miR-361-5p SMAD4 -0.138735309928775 0.941495130308343 -0.473107439957935 0.714784528258547 mirMAP -0.25694604812623 0.000622808366001207 NA NA NA hsa-miR-369-3p SMAD4 0.116576891957687 0.83230082995912 -0.473107439957935 0.714784528258547 mirMAP -0.129702032821106 0.00443370777607746 NA NA NA hsa-miR-374a-5p SMAD4 -0.343007247142618 0.766921280269271 -0.473107439957935 0.714784528258547 mirMAP -0.172312563460398 0.00687195386161141 NA NA NA hsa-miR-374b-5p SMAD4 -0.285682091626878 0.83569830479965 -0.473107439957935 0.714784528258547 mirMAP -0.199204180191632 0.00121736577828174 NA NA NA hsa-miR-377-3p SMAD4 -0.0435868040110954 0.893514136702459 -0.473107439957935 0.714784528258547 MirTarget -0.101669454382718 0.00980370784502512 NA NA NA hsa-miR-425-5p SMAD4 -0.354606074344121 0.845979106734409 -0.473107439957935 0.714784528258547 mirMAP -0.130531407894903 0.00133502406681675 NA NA NA hsa-miR-450b-5p SMAD4 -0.0136687538973108 0.983149761399849 -0.473107439957935 0.714784528258547 mirMAP -0.196219534294055 1.87736804832562e-05 NA NA NA hsa-miR-454-3p SMAD4 -0.101514866328011 0.843545158256191 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;miRNATAP -0.168274939805476 0.00152054988480945 NA NA NA hsa-miR-500a-5p SMAD4 -0.71978560736831 0.188073776225276 -0.473107439957935 0.714784528258547 mirMAP -0.121458878900978 0.00137356923942353 NA NA NA hsa-miR-539-5p SMAD4 0.124342970087029 0.801067485473643 -0.473107439957935 0.714784528258547 mirMAP -0.180979731505977 0.000193930709263202 NA NA NA hsa-miR-92a-3p SMAD4 0.0278830870766349 0.993247426671713 -0.473107439957935 0.714784528258547 miRNAWalker2_validate;mirMAP -0.174217160676192 0.000127132683719261 NA NA NA hsa-miR-141-3p SOX17 -0.31994058840327 0.87774106909065 0.240581045871685 0.418965556479622 TargetScan -0.505272437332591 1.25420548567418e-18 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-26b-5p SOX17 -0.0245931278499594 0.990377966314923 0.240581045871685 0.418965556479622 miRNATAP -0.448560421877652 3.02586486560545e-06 NA NA NA hsa-miR-362-3p SOX17 -0.721040238345347 0.0345881362485733 0.240581045871685 0.418965556479622 miRanda;miRNATAP -0.233525315540409 7.22889165806902e-05 NA NA NA hsa-miR-421 SOX17 -0.182032017078616 0.734704500318599 0.240581045871685 0.418965556479622 miRanda -0.309803627619118 6.95401202129939e-06 NA NA NA hsa-miR-590-3p SOX17 -0.279244755376859 0.59126669933662 0.240581045871685 0.418965556479622 miRanda;miRNATAP -0.388805234838502 2.97465992398104e-11 NA NA NA hsa-miR-590-5p SOX17 -0.547819833829572 0.472735645776647 0.240581045871685 0.418965556479622 miRanda -0.445655717411623 3.44617971274194e-13 NA NA NA hsa-miR-552-3p TBL1X 0.172135417326455 0.893972136172394 -0.138862312849978 0.90583945234065 MirTarget -0.11586445243707 0.000275016300053242 NA NA NA hsa-miR-92a-3p TBL1X 0.0278830870766349 0.993247426671713 -0.138862312849978 0.90583945234065 miRNAWalker2_validate;mirMAP -0.187523741777201 0.00706483083410881 NA NA NA hsa-miR-215-5p TCF7 -0.142648109361913 0.94480931294964 0.423582866808512 0.74688431641332 miRNAWalker2_validate;MirTarget -0.113272334004619 0.00078883184611383 NA NA NA hsa-miR-106a-5p TCF7L1 -0.203919267842652 0.802213958426804 0.402717210708942 0.479661024937114 MirTarget -0.21691074540819 5.98128103884481e-05 NA NA NA hsa-miR-106b-5p TCF7L1 -0.297128724729339 0.869294443540749 0.402717210708942 0.479661024937114 MirTarget -0.412207115212278 9.54365057247493e-12 NA NA NA hsa-miR-130b-5p TCF7L1 -0.6472141103776 0.379096015222509 0.402717210708942 0.479661024937114 MirTarget -0.430096414874045 3.34739484224554e-18 NA NA NA hsa-miR-141-3p TCF7L1 -0.31994058840327 0.87774106909065 0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.389033714201084 1.55531817646511e-19 NA NA NA hsa-miR-15b-3p TCF7L1 -0.557749208157585 0.609181305423188 0.402717210708942 0.479661024937114 miRNATAP -0.452339426428614 8.00077498147628e-18 NA NA NA hsa-miR-17-5p TCF7L1 -0.175448849583061 0.934544015912731 0.402717210708942 0.479661024937114 MirTarget;TargetScan -0.339876699903084 9.56782264800795e-14 NA NA NA hsa-miR-185-3p TCF7L1 0.100697585937245 0.856913315942984 0.402717210708942 0.479661024937114 MirTarget -0.296594224756213 7.44596441436389e-08 NA NA NA hsa-miR-200a-3p TCF7L1 -0.367034437440907 0.851059894150266 0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.326465298240901 3.19723425626494e-14 NA NA NA hsa-miR-200b-3p TCF7L1 -0.426401948379212 0.863957108574195 0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.399103284306769 2.79238660952596e-15 NA NA NA hsa-miR-200c-3p TCF7L1 -0.437282635857873 0.887118598436407 0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.456660723450383 3.42232996019783e-19 NA NA NA hsa-miR-20a-5p TCF7L1 -0.179153323927949 0.928118119139752 0.402717210708942 0.479661024937114 MirTarget -0.326990829611436 4.20690649775668e-13 NA NA NA hsa-miR-30b-3p TCF7L1 -0.514644352757504 0.162424853398397 0.402717210708942 0.479661024937114 MirTarget -0.174144109162913 0.00106959143964259 NA NA NA hsa-miR-30d-3p TCF7L1 -0.123474741320298 0.814905367625791 0.402717210708942 0.479661024937114 miRNATAP -0.389219323366683 3.77571986631102e-11 NA NA NA hsa-miR-330-5p TCF7L1 -0.283418953659271 0.815687101334695 0.402717210708942 0.479661024937114 miRanda -0.269034351012755 0.000169924948942531 NA NA NA hsa-miR-362-3p TCF7L1 -0.721040238345347 0.0345881362485733 0.402717210708942 0.479661024937114 miRanda;miRNATAP -0.145155275233058 0.00113678308619884 NA NA NA hsa-miR-429 TCF7L1 -0.456485631615963 0.806240953400535 0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.307353177790098 9.01368010301532e-14 NA NA NA hsa-miR-455-3p TCF7L1 -0.356341681711462 0.824635754440661 0.402717210708942 0.479661024937114 MirTarget;PITA;miRNATAP -0.199039470590073 1.28390243824511e-05 NA NA NA hsa-miR-505-5p TCF7L1 -0.555858818875454 0.317679205488749 0.402717210708942 0.479661024937114 miRNATAP -0.172159223594929 0.00156319164765094 NA NA NA hsa-miR-590-3p TCF7L1 -0.279244755376859 0.59126669933662 0.402717210708942 0.479661024937114 PITA;miRanda;miRNATAP -0.27937911706307 2.83048341888801e-10 NA NA NA hsa-miR-93-5p TCF7L1 -0.611073677204699 0.825297877093193 0.402717210708942 0.479661024937114 MirTarget -0.496656931304449 1.80732700371685e-19 NA NA NA hsa-miR-181c-5p TCF7L2 0.042951891660695 0.969159991881861 -0.181990807545402 0.892393784585701 MirTarget;miRNATAP -0.182504714347455 4.52985731683706e-06 NA NA NA hsa-miR-181d-5p TCF7L2 0.14926527647499 0.888000971478017 -0.181990807545402 0.892393784585701 MirTarget -0.147785025284075 2.08206281204787e-06 NA NA NA hsa-miR-217 TCF7L2 0.341080669095094 0.760998144794468 -0.181990807545402 0.892393784585701 MirTarget;miRanda;miRNATAP -0.131869664076788 3.56283866566372e-06 NA NA NA hsa-miR-328-3p TCF7L2 -0.27090542057371 0.758001839490036 -0.181990807545402 0.892393784585701 MirTarget -0.130013349047585 0.0022585586655471 27181358 microRNA 328 inhibits cervical cancer cell proliferation and tumorigenesis by targeting TCF7L2; Bioinformatic analysis predicted TCF7L2 an essential effector of canonical Wnt signaling as a target gene of miR-328 which was confirmed by luciferase reporter assays; Enforced expression of miR-328 led to a decline in the expression of endogenous TCF7L2 in cervical cancer cells; In cervical cancer tissues TCF7L2 protein levels were negatively correlated with miR-328 expression levels r = -0.462 P = 0.017; Taken together our results provide first evidence for the growth suppressive activity of miR-328 in cervical cancer which is largely ascribed to downregulation of TCF7L2 tumorigenesis cervical and endocervical cancer hsa-miR-107 VANGL2 -0.0365118169251648 0.988364120226869 0.770212725792587 0.428663186498278 miRanda -0.807781900082149 0.00016788703446867 NA NA NA hsa-miR-128-3p VANGL2 -0.442192625156042 0.783886533572187 0.770212725792587 0.428663186498278 MirTarget -0.770108272633921 2.20660721465527e-06 NA NA NA hsa-miR-140-3p VANGL2 -0.369894078407761 0.864762211761539 0.770212725792587 0.428663186498278 PITA;miRNATAP -0.647747992178188 0.00395685282883934 NA NA NA hsa-miR-146b-3p VANGL2 -0.408862981477661 0.762520540478861 0.770212725792587 0.428663186498278 PITA -0.50552073600027 0.000239723916823666 NA NA NA hsa-miR-15b-3p VANGL2 -0.557749208157585 0.609181305423188 0.770212725792587 0.428663186498278 mirMAP -0.401999984080657 0.00229347543247302 NA NA NA hsa-miR-185-5p VANGL2 -0.294432218239008 0.820591478398594 0.770212725792587 0.428663186498278 MirTarget -0.947618694049307 7.69631125196326e-08 NA NA NA hsa-miR-186-5p VANGL2 -0.318786974828757 0.85412722938961 0.770212725792587 0.428663186498278 mirMAP -0.55364799391336 0.00208700934239534 NA NA NA hsa-miR-378a-5p VANGL2 -0.559739196974497 0.724882066659501 0.770212725792587 0.428663186498278 MirTarget -0.584327633917235 5.88352893260458e-06 NA NA NA hsa-miR-582-3p VANGL2 -0.2334649592375 0.897678119160318 0.770212725792587 0.428663186498278 mirMAP -0.804371500108253 5.63987309154999e-10 NA NA NA hsa-miR-582-5p VANGL2 -0.399450205475138 0.581227478860085 0.770212725792587 0.428663186498278 PITA;miRNATAP -0.690340717676146 4.03305116081449e-07 NA NA NA hsa-miR-589-3p VANGL2 -0.835836305204965 0.0112001563801511 0.770212725792587 0.428663186498278 mirMAP -0.4339142568251 1.04748945058037e-05 NA NA NA hsa-miR-589-5p VANGL2 -0.448771545046784 0.722725226273464 0.770212725792587 0.428663186498278 mirMAP -1.03377046370619 1.42124169834202e-09 NA NA NA hsa-miR-590-3p VANGL2 -0.279244755376859 0.59126669933662 0.770212725792587 0.428663186498278 miRanda -0.361471944680754 0.000701950705597688 NA NA NA hsa-miR-7-1-3p VANGL2 -0.462485777435991 0.665899751398166 0.770212725792587 0.428663186498278 mirMAP -0.399774420919523 0.00140377240024295 NA NA NA hsa-miR-140-3p WIF1 -0.369894078407761 0.864762211761539 3.12129939931488 0.00672337737058921 PITA;miRNATAP -1.21449670840685 0.00961626522437693 NA NA NA hsa-miR-330-5p WIF1 -0.283418953659271 0.815687101334695 3.12129939931488 0.00672337737058921 miRanda -1.0602726241873 0.00242528794989799 NA NA NA hsa-miR-19a-3p WNT10A -0.206793507801887 0.844637784802316 1.2947270954084 0.00683452748884356 MirTarget -0.280344560866448 0.00716394186440647 NA NA NA hsa-miR-378a-3p WNT10A -0.466787210598086 0.795055970353024 1.2947270954084 0.00683452748884356 MirTarget;miRNATAP -0.809623599709609 1.68920044926608e-09 NA NA NA hsa-miR-320b WNT11 -0.23561798088153 0.859222532827992 0.846684604893891 0.327218753036276 miRanda -0.483289474025952 0.0057861641086482 NA NA NA hsa-miR-590-3p WNT11 -0.279244755376859 0.59126669933662 0.846684604893891 0.327218753036276 miRanda -0.393195454255055 0.00396388290763855 NA NA NA hsa-let-7f-2-3p WNT2 -0.0455032713433074 0.882115725419367 -0.192152888155767 0.80294757941918 MirTarget -0.31367220718444 0.000142400795929771 NA NA NA hsa-miR-324-5p WNT2 -0.50063248413014 0.537416710557032 -0.192152888155767 0.80294757941918 miRanda -0.404913499355749 5.75064761167337e-05 NA NA NA hsa-miR-362-3p WNT2 -0.721040238345347 0.0345881362485733 -0.192152888155767 0.80294757941918 miRanda -0.255418262791256 0.00108695919289387 NA NA NA hsa-miR-577 WNT2 -1.06238199218774 0.326056761787754 -0.192152888155767 0.80294757941918 mirMAP -0.268129452381093 4.12459242014742e-08 NA NA NA hsa-miR-590-3p WNT2 -0.279244755376859 0.59126669933662 -0.192152888155767 0.80294757941918 miRanda;mirMAP -0.444773305200754 1.33937644848683e-08 NA NA NA hsa-miR-624-5p WNT2 -0.348001560408561 0.190596385087429 -0.192152888155767 0.80294757941918 MirTarget -0.284532111230919 0.00320950928771027 NA NA NA hsa-miR-130b-3p WNT2B -0.221667315324818 0.824660172394714 -0.195424109020966 0.588361255800061 MirTarget -0.411446493536916 9.35087433257479e-06 NA NA NA hsa-miR-186-5p WNT2B -0.318786974828757 0.85412722938961 -0.195424109020966 0.588361255800061 mirMAP -0.464159719190634 0.000272355594684683 NA NA NA hsa-miR-301a-3p WNT2B -0.105312511901769 0.831686745977347 -0.195424109020966 0.588361255800061 MirTarget -0.24078108892737 0.0023935532988976 NA NA NA hsa-miR-32-3p WNT2B -0.568003960723004 0.13133163420273 -0.195424109020966 0.588361255800061 mirMAP -0.340317399528653 1.37992605748722e-07 NA NA NA hsa-miR-429 WNT2B -0.456485631615963 0.806240953400535 -0.195424109020966 0.588361255800061 miRNATAP -0.188547746324961 0.00911550819171564 NA NA NA hsa-miR-576-5p WNT2B -0.506413219377403 0.417187951364173 -0.195424109020966 0.588361255800061 mirMAP -0.394145786131296 1.28809135783959e-05 NA NA NA hsa-miR-141-3p WNT5A -0.31994058840327 0.87774106909065 0.110395814147502 0.914533916034388 TargetScan -0.200256432563993 0.00734521574657962 NA NA NA hsa-miR-142-3p WNT5A -0.154235241441331 0.946098054588918 0.110395814147502 0.914533916034388 miRanda -0.187899116765242 0.00904321421713111 NA NA NA hsa-miR-16-2-3p WNT5A -0.36717860153421 0.546850726070016 0.110395814147502 0.914533916034388 MirTarget;mirMAP -0.294711224902512 0.000237971109061575 NA NA NA hsa-miR-16-5p WNT5A 0.0135949734723564 0.994476223855607 0.110395814147502 0.914533916034388 miRNAWalker2_validate -0.346963132050484 0.000435924342023163 NA NA NA hsa-miR-2110 WNT5A -0.317803483266315 0.250981343062022 0.110395814147502 0.914533916034388 MirTarget -0.232380496146916 0.00643379925097321 NA NA NA hsa-miR-26b-5p WNT5A -0.0245931278499594 0.990377966314923 0.110395814147502 0.914533916034388 mirMAP;miRNATAP -0.509082056076659 1.15546257563017e-05 NA NA NA hsa-miR-29a-5p WNT5A -0.31835175571979 0.600442757817281 0.110395814147502 0.914533916034388 mirMAP -0.407216737734173 2.20425129530399e-07 NA NA NA hsa-miR-30b-5p WNT5A -0.0121430518253582 0.994622896704513 0.110395814147502 0.914533916034388 mirMAP -0.298279258206302 0.00052297416246863 NA NA NA hsa-miR-30c-5p WNT5A -0.298383882401475 0.865809030482001 0.110395814147502 0.914533916034388 mirMAP -0.417687486836998 0.000711235673044307 NA NA NA hsa-miR-30d-3p WNT5A -0.123474741320298 0.814905367625791 0.110395814147502 0.914533916034388 mirMAP -0.266459105337685 0.00655468873705503 NA NA NA hsa-miR-30e-5p WNT5A -0.0657075181381011 0.979684509181941 0.110395814147502 0.914533916034388 mirMAP -0.585909749322998 1.49944496326228e-05 NA NA NA hsa-miR-32-3p WNT5A -0.568003960723004 0.13133163420273 0.110395814147502 0.914533916034388 mirMAP -0.253231752844851 5.83856141848488e-05 NA NA NA hsa-miR-374b-5p WNT5A -0.285682091626878 0.83569830479965 0.110395814147502 0.914533916034388 MirTarget;miRNATAP -0.323060205878665 0.0081531705977795 NA NA NA hsa-miR-577 WNT5A -1.06238199218774 0.326056761787754 0.110395814147502 0.914533916034388 mirMAP;miRNATAP -0.14481253749716 0.00149232098483259 NA NA NA hsa-miR-590-3p WNT5A -0.279244755376859 0.59126669933662 0.110395814147502 0.914533916034388 miRanda;mirMAP;miRNATAP -0.291267105119937 6.18332465631002e-05 NA NA NA hsa-miR-185-5p WNT5B -0.294432218239008 0.820591478398594 0.491055180051108 0.357654560612429 miRNAWalker2_validate -0.639977601759009 3.71646674746466e-07 NA NA NA hsa-miR-1275 WNT7B -0.831342050607648 0.0803795852164229 0.579474423316968 0.320796252982003 MirTarget -0.387011416230313 3.97032686658408e-05 NA NA NA hsa-miR-30c-5p WNT7B -0.298383882401475 0.865809030482001 0.579474423316968 0.320796252982003 miRNATAP -0.609277220928699 0.00419481010924774 NA NA NA hsa-miR-335-5p WNT7B -0.0284895175847679 0.973380867832231 0.579474423316968 0.320796252982003 miRNAWalker2_validate -0.734733101983856 5.31852216140117e-08 NA NA NA hsa-miR-491-5p WNT7B -0.585652105321328 0.0452620602586908 0.579474423316968 0.320796252982003 mirMAP -0.409843426261441 0.00236577186287215 NA NA NA hsa-let-7a-3p WNT9A -0.215598045625677 0.85543299203799 -0.153288538485221 0.811910238707686 mirMAP -0.60525455253825 2.36092027856041e-06 NA NA NA hsa-let-7a-5p WNT9A -0.0620211756550422 0.985006886285188 -0.153288538485221 0.811910238707686 TargetScan -0.568486505273013 0.0080880571890765 NA NA NA hsa-let-7f-1-3p WNT9A -0.31101436822914 0.693407210545374 -0.153288538485221 0.811910238707686 mirMAP -1.0981342306459 1.51256643998465e-10 NA NA NA hsa-miR-1226-3p WNT9A -0.346825224699346 0.341199987121208 -0.153288538485221 0.811910238707686 mirMAP -0.367979637626545 8.58417655024235e-05 NA NA NA hsa-miR-1227-3p WNT9A -0.540231719582615 0.10763778383609 -0.153288538485221 0.811910238707686 mirMAP -0.342367584962106 0.000195356108595552 NA NA NA hsa-miR-148a-3p WNT9A -0.101286586375016 0.976980454193186 -0.153288538485221 0.811910238707686 mirMAP -0.727159860797041 4.81139328883011e-10 NA NA NA hsa-miR-148b-3p WNT9A -0.202106692287125 0.911884960581838 -0.153288538485221 0.811910238707686 mirMAP -1.03824120135403 3.54388608600412e-10 NA NA NA hsa-miR-15a-5p WNT9A -0.0674049094129128 0.964835434214123 -0.153288538485221 0.811910238707686 mirMAP -1.00838814485289 6.08146492384368e-14 NA NA NA hsa-miR-15b-5p WNT9A -0.272614787130877 0.87096541832188 -0.153288538485221 0.811910238707686 mirMAP -0.788885072703751 8.94472879251289e-10 NA NA NA hsa-miR-16-5p WNT9A 0.0135949734723564 0.994476223855607 -0.153288538485221 0.811910238707686 mirMAP -0.883328197188995 3.2849457106567e-12 NA NA NA hsa-miR-185-3p WNT9A 0.100697585937245 0.856913315942984 -0.153288538485221 0.811910238707686 mirMAP -0.477594137876954 6.62786909341971e-05 NA NA NA hsa-miR-193a-3p WNT9A -0.247265785363732 0.654363581941634 -0.153288538485221 0.811910238707686 mirMAP -0.370112102920161 0.000772158605117855 NA NA NA hsa-miR-32-5p WNT9A -0.05993267619119 0.952975951594959 -0.153288538485221 0.811910238707686 mirMAP -0.717387367647511 9.24418428665514e-11 NA NA NA hsa-miR-331-3p WNT9A -0.40204226129616 0.670588911553669 -0.153288538485221 0.811910238707686 mirMAP -0.509120952690381 4.87286430113257e-05 NA NA NA hsa-miR-335-5p WNT9A -0.0284895175847679 0.973380867832231 -0.153288538485221 0.811910238707686 miRNAWalker2_validate -0.718753005182524 3.00490464793997e-12 NA NA NA hsa-miR-424-5p WNT9A 0.247080963500746 0.870154571783568 -0.153288538485221 0.811910238707686 mirMAP -0.375571816715529 0.000119556541853369 NA NA NA hsa-miR-532-3p WNT9A -0.496590111092324 0.682889021782543 -0.153288538485221 0.811910238707686 mirMAP -0.683784250002974 1.75153006152263e-11 NA NA NA hsa-miR-589-3p WNT9A -0.835836305204965 0.0112001563801511 -0.153288538485221 0.811910238707686 mirMAP -0.485995950011792 5.23330245294823e-08 NA NA NA hsa-miR-96-5p WNT9A 0.0854810872029343 0.923087820185031 -0.153288538485221 0.811910238707686 mirMAP -0.642828847170393 3.29804586928251e-11 NA NA NA