miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-223-3p ABI2 1.08589180128329 0.000115241553609245 0.175334214271024 0.14786862779391 MirTarget -0.147053760394056 5.66807920781906e-09 NA NA NA hsa-miR-223-3p ACVR2A 1.08589180128329 0.000115241553609245 -0.409014715537696 0.000390733013426116 MirTarget -0.136224751211655 2.10520148640394e-08 NA NA NA hsa-miR-223-3p ANKRD40 1.08589180128329 0.000115241553609245 -0.0360966874451325 0.671697103026014 MirTarget -0.109750206338597 3.87458183288237e-10 NA NA NA hsa-miR-223-3p ANTXR1 1.08589180128329 0.000115241553609245 0.824541697719349 0.00013866646046424 mirMAP -0.130352679466583 0.00544851044450074 NA NA NA hsa-miR-223-3p AR 1.08589180128329 0.000115241553609245 -1.55428586679464 3.79681953414866e-06 mirMAP -0.495108035844875 2.38292251129941e-12 NA NA NA hsa-miR-223-3p ARMCX1 1.08589180128329 0.000115241553609245 -1.27825493561566 1.80518168021065e-08 MirTarget -0.353872654157633 1.44803525718495e-13 NA NA NA hsa-miR-223-3p BRMS1L 1.08589180128329 0.000115241553609245 -0.0230166379516636 0.82317459332355 MirTarget -0.105248728878702 1.07375252557359e-06 NA NA NA hsa-miR-223-3p CCKBR 1.08589180128329 0.000115241553609245 -5.31152820935511 1.18733227809057e-16 MirTarget -0.570885507422348 8.42912945251933e-05 NA NA NA hsa-miR-223-3p CREBRF 1.08589180128329 0.000115241553609245 -0.366122742256368 0.00726639317725131 MirTarget -0.209767357707041 6.78280553279363e-14 NA NA NA hsa-miR-223-3p CXXC4 1.08589180128329 0.000115241553609245 -0.432816361201401 0.210546329161834 MirTarget -0.40849524168773 1.69971947831377e-08 NA NA NA hsa-miR-223-3p CYBRD1 1.08589180128329 0.000115241553609245 -1.57319886365625 1.13822187395473e-09 MirTarget -0.36806126261671 2.79763845022291e-11 NA NA NA hsa-miR-223-3p DIRAS1 1.08589180128329 0.000115241553609245 -2.51816590430994 6.90315545782969e-10 mirMAP -0.497546822774267 1.91054067221221e-08 NA NA NA hsa-miR-223-3p EBF2 1.08589180128329 0.000115241553609245 1.62736261668709 2.99671818165223e-06 MirTarget -0.209109307069091 0.00600917106311566 NA NA NA hsa-miR-223-3p EPHA3 1.08589180128329 0.000115241553609245 0.184866448700745 0.535876012219245 MirTarget -0.351654197105611 1.83304584109183e-08 NA NA NA hsa-miR-223-3p FAM120C 1.08589180128329 0.000115241553609245 0.170776103390755 0.263203241775743 MirTarget -0.133318093919416 3.74488278705244e-05 NA NA NA hsa-miR-223-3p FAM188A 1.08589180128329 0.000115241553609245 -0.440254863510343 0.000176623974619799 MirTarget -0.119043381789926 1.8970619862064e-06 NA NA NA hsa-miR-223-3p FAM212B 1.08589180128329 0.000115241553609245 -0.999900600735786 4.86315864880706e-07 mirMAP -0.174324140879073 5.34027183898686e-05 NA NA NA hsa-miR-223-3p FBXO8 1.08589180128329 0.000115241553609245 -0.72930231031825 3.20491429160655e-16 MirTarget -0.111419121191167 1.62169298855297e-08 NA NA NA hsa-miR-223-3p FGF2 1.08589180128329 0.000115241553609245 -1.0252152469847 2.26010255795334e-05 MirTarget -0.296362887760396 8.00058219829246e-09 NA NA NA hsa-miR-223-3p GABRB2 1.08589180128329 0.000115241553609245 -1.84121195758661 0.000285346502585098 mirMAP -0.415264071785017 0.0001449575396767 NA NA NA hsa-miR-223-3p HCFC2 1.08589180128329 0.000115241553609245 -0.716945650565211 4.70460742079511e-08 MirTarget -0.195394724948646 1.66633488540134e-12 NA NA NA hsa-miR-223-3p IDS 1.08589180128329 0.000115241553609245 -0.0995092469681822 0.452237040895841 mirMAP -0.140902757018387 3.89900217251873e-07 NA NA NA hsa-miR-223-3p IGFBP5 1.08589180128329 0.000115241553609245 -0.805513625701275 0.00105250959314417 mirMAP -0.157436174585741 0.00301070157136845 NA NA NA hsa-miR-223-3p IL6ST 1.08589180128329 0.000115241553609245 -0.401511913072166 0.00675820073922165 MirTarget -0.144220022115267 4.56706404161102e-06 NA NA NA hsa-miR-223-3p INPP5B 1.08589180128329 0.000115241553609245 -0.0687250805364314 0.555809437992918 MirTarget -0.119474512466669 1.06269222728566e-06 NA NA NA hsa-miR-223-3p ITGA9 1.08589180128329 0.000115241553609245 -0.825924039856462 0.00174155829133973 mirMAP -0.304280017536736 4.90140535172186e-08 24333181 Our aim was to investigate miR-223 regulation in HCC miR-223 and integrin αV dysregulation were verified in 57 HCC specimens; Enhanced miR-223 expression had a negative effect on integrin αV-mediated cell migration; Further analysis demonstrated that integrin αV is negatively regulated by miR-223 cell migration liver cancer hsa-miR-223-3p KCND3 1.08589180128329 0.000115241553609245 -1.25081349685282 8.58949377013892e-05 mirMAP -0.175074267490299 0.0114486553202038 NA NA NA hsa-miR-223-3p KIAA1456 1.08589180128329 0.000115241553609245 -0.824815382979913 0.00346285725933416 mirMAP -0.272987964736794 5.5960963326456e-06 NA NA NA hsa-miR-223-3p KIAA1614 1.08589180128329 0.000115241553609245 -0.672817277076573 0.000878485556645909 mirMAP -0.238583519562819 2.36015951392495e-08 NA NA NA hsa-miR-223-3p KLF12 1.08589180128329 0.000115241553609245 -0.391196935968631 0.0893097621844466 mirMAP -0.200577846347979 4.17379674299965e-05 NA NA NA hsa-miR-223-3p LRIG1 1.08589180128329 0.000115241553609245 -0.5374742879248 0.00587721628379153 MirTarget -0.237280671253109 7.14064661832173e-09 NA NA NA hsa-miR-223-3p MAPK4 1.08589180128329 0.000115241553609245 -3.20102969321359 3.36120356375601e-07 mirMAP -0.987623127578717 5.97470264840085e-14 NA NA NA hsa-miR-223-3p MDGA1 1.08589180128329 0.000115241553609245 -0.700553829949079 0.00274428133644597 mirMAP -0.121062755789751 0.0166075200488396 NA NA NA hsa-miR-223-3p MEF2C 1.08589180128329 0.000115241553609245 -0.498587747456098 0.014475128958342 miRNAWalker2_validate;miRTarBase;MirTarget -0.133323022948975 0.00231875024371663 NA NA NA hsa-miR-223-3p MMP16 1.08589180128329 0.000115241553609245 0.339181683389834 0.222873688272483 mirMAP -0.189926320649944 0.00140598924450402 NA NA NA hsa-miR-223-3p MTSS1 1.08589180128329 0.000115241553609245 -0.810088738785264 0.000353714566592768 MirTarget -0.231472357816171 1.71429671415778e-06 NA NA NA hsa-miR-223-3p NDNF 1.08589180128329 0.000115241553609245 -1.51391923305532 5.24454277418782e-05 MirTarget -0.443491129563394 2.51483697639316e-08 NA NA NA hsa-miR-223-3p NFIA 1.08589180128329 0.000115241553609245 -0.546116799329663 0.00406390884761114 miRNAWalker2_validate;miRTarBase;MirTarget -0.286475293890391 2.83293505238042e-13 NA NA NA hsa-miR-223-3p NFIB 1.08589180128329 0.000115241553609245 0.0225947120786127 0.907947126450015 MirTarget -0.11821072352159 0.00463819164879456 NA NA NA hsa-miR-223-3p NFIX 1.08589180128329 0.000115241553609245 -0.625715797314676 0.000190034636172099 miRNAWalker2_validate;miRTarBase -0.153261685475552 1.99262162673048e-05 NA NA NA hsa-miR-223-3p NIPAL3 1.08589180128329 0.000115241553609245 -0.452440485746727 1.87765980659022e-05 MirTarget -0.106913936677214 2.18288349405097e-06 NA NA NA hsa-miR-223-3p NPTXR 1.08589180128329 0.000115241553609245 -1.00186986119569 0.00367721137641764 mirMAP -0.4551484857754 2.90600429179062e-10 NA NA NA hsa-miR-223-3p PTPRT 1.08589180128329 0.000115241553609245 -0.907265605799675 0.0372664951342187 mirMAP -0.285506892039941 0.00225649452860454 NA NA NA hsa-miR-223-3p RBM20 1.08589180128329 0.000115241553609245 -1.95734925558392 5.80934241681352e-07 MirTarget -0.537799253185673 9.75675578787859e-11 NA NA NA hsa-miR-223-3p RERG 1.08589180128329 0.000115241553609245 -1.38824246645131 5.44069155315798e-05 MirTarget -0.502248284998694 2.91003772334018e-12 NA NA NA hsa-miR-223-3p RHOB 1.08589180128329 0.000115241553609245 -1.05159658010263 6.81750709839854e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.219652605682161 1.5054730031161e-06 NA NA NA hsa-miR-223-3p RILPL1 1.08589180128329 0.000115241553609245 -0.155445831659137 0.273241390893801 MirTarget -0.153410961279612 2.57090585816582e-07 NA NA NA hsa-miR-223-3p RORA 1.08589180128329 0.000115241553609245 -0.888667376601635 4.99889595160793e-06 mirMAP -0.235132112373145 1.42733163475393e-08 NA NA NA hsa-miR-223-3p SACS 1.08589180128329 0.000115241553609245 0.342780111245514 0.116894496849562 MirTarget -0.123792454306375 0.00828273112139121 NA NA NA hsa-miR-223-3p SCN2A 1.08589180128329 0.000115241553609245 0.317164447705599 0.477497388671926 MirTarget -0.275445015684599 0.00394945430778213 NA NA NA hsa-miR-223-3p SCN2B 1.08589180128329 0.000115241553609245 -2.22237853128849 2.58947336008345e-06 mirMAP -0.702657646131981 1.48965158829245e-12 NA NA NA hsa-miR-223-3p SCN3A 1.08589180128329 0.000115241553609245 -1.5009210460306 8.66949811687225e-07 MirTarget -0.305679967556986 3.52812458725686e-06 NA NA NA hsa-miR-223-3p SDK2 1.08589180128329 0.000115241553609245 -0.581686295778627 0.0604550673556843 mirMAP -0.182329079218867 0.00613275305140723 NA NA NA hsa-miR-223-3p SEPT10 1.08589180128329 0.000115241553609245 -0.29436849945031 0.0169826283606985 MirTarget -0.111225859399072 2.13291857849928e-05 NA NA NA hsa-miR-223-3p SLC2A4 1.08589180128329 0.000115241553609245 -2.41796075460274 1.09847746343808e-09 miRNAWalker2_validate;miRTarBase -0.600014706358509 1.22174723099208e-12 NA NA NA hsa-miR-223-3p SOGA1 1.08589180128329 0.000115241553609245 0.164842490647963 0.469140269986253 mirMAP -0.177910109078277 0.000240954411334558 NA NA NA hsa-miR-223-3p SSBP2 1.08589180128329 0.000115241553609245 -1.58025310656881 5.21464030760244e-12 MirTarget -0.314832640926872 2.31220518531486e-10 NA NA NA hsa-miR-223-3p SV2B 1.08589180128329 0.000115241553609245 -0.292959637600184 0.363390606978728 MirTarget -0.203477332795296 0.00317103965561686 NA NA NA hsa-miR-223-3p TBC1D17 1.08589180128329 0.000115241553609245 -0.53587908514201 2.48405101408047e-08 MirTarget -0.117799623781636 9.82865906043617e-09 NA NA NA hsa-miR-223-3p TEAD1 1.08589180128329 0.000115241553609245 -0.180963993433754 0.334001704599182 mirMAP -0.251894152916145 8.37999680029909e-11 NA NA NA hsa-miR-223-3p TGFBR3 1.08589180128329 0.000115241553609245 -1.17329353105567 5.76332601597347e-06 MirTarget -0.317918505888099 7.84601502981405e-09 NA NA NA hsa-miR-223-3p TMEM47 1.08589180128329 0.000115241553609245 -0.85850651693283 0.00027718244841934 MirTarget -0.316773729439943 1.65104632726797e-10 NA NA NA hsa-miR-223-3p TMOD2 1.08589180128329 0.000115241553609245 -0.644687820828108 0.00111217170460963 mirMAP -0.229484941265766 4.01027602135603e-08 NA NA NA hsa-miR-223-3p TOX 1.08589180128329 0.000115241553609245 -1.5520618363727 1.65462553105166e-07 MirTarget -0.251328219187793 0.000100985862905719 24304814 In addition we showed that the 3'-UTR of TOX mRNA was a genuine target of miR-223 lymphoma hsa-miR-223-3p TRIL 1.08589180128329 0.000115241553609245 -0.258907477913871 0.199355796714117 MirTarget -0.148887938680641 0.000537752296714914 NA NA NA hsa-miR-223-3p ULK2 1.08589180128329 0.000115241553609245 -0.507777916304274 0.00720267539139616 MirTarget -0.191903801165695 1.6820646882792e-06 NA NA NA hsa-miR-223-3p YPEL1 1.08589180128329 0.000115241553609245 -0.191540592356424 0.0956078951843983 MirTarget -0.134041252475522 2.35762095948141e-08 NA NA NA hsa-miR-223-3p ZFHX3 1.08589180128329 0.000115241553609245 0.388625553932512 0.0136343956376204 MirTarget -0.200460962552162 1.12382312596535e-09 NA NA NA hsa-miR-223-3p ZIC1 1.08589180128329 0.000115241553609245 -0.00280595979734599 0.996236581215562 mirMAP -0.374386372110209 0.00325885527090195 NA NA NA hsa-miR-223-3p ZNF286B 1.08589180128329 0.000115241553609245 0.521780413052623 0.000123424975876976 mirMAP -0.107554559218475 0.000234293354741042 NA NA NA hsa-miR-223-3p ZNF365 1.08589180128329 0.000115241553609245 0.197703399755446 0.570502929787385 MirTarget -0.404521491641993 3.00895030404083e-08 NA NA NA hsa-miR-223-3p ZNF772 1.08589180128329 0.000115241553609245 -0.0126936459846325 0.959345668610764 MirTarget -0.165409547898306 0.00186216265644294 NA NA NA