miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p ABL1 0.604314269683977 0.00140009936153214 -1.32037015957096 1.87647767985755e-18 miRNAWalker2_validate -0.231253752376574 6.2902850853714e-09 NA NA NA hsa-miR-128-3p ABL1 1.63756041666078 6.79626586407187e-14 -1.32037015957096 1.87647767985755e-18 MirTarget -0.210223041949341 2.63836453167807e-10 NA NA NA hsa-miR-136-5p ABL1 2.09637138292451 1.50140005592201e-10 -1.32037015957096 1.87647767985755e-18 mirMAP -0.120417712577766 7.75492266171278e-08 NA NA NA hsa-miR-140-3p ABL1 0.0608890720479334 0.727716871248724 -1.32037015957096 1.87647767985755e-18 MirTarget;PITA -0.14166082047536 0.00130100831768621 NA NA NA hsa-miR-141-3p ABL1 5.02396127982626 2.19224509139725e-24 -1.32037015957096 1.87647767985755e-18 MirTarget -0.175107254317894 1.9871253927784e-40 NA NA NA hsa-miR-149-5p ABL1 2.94200492826326 4.93436498919036e-14 -1.32037015957096 1.87647767985755e-18 miRNAWalker2_validate -0.143502376394447 3.49799913508757e-15 NA NA NA hsa-miR-15b-3p ABL1 2.33847028227712 4.29662877950836e-19 -1.32037015957096 1.87647767985755e-18 MirTarget -0.226389114724505 2.98490463631649e-17 NA NA NA hsa-miR-15b-5p ABL1 1.57112623124278 9.14247846750597e-13 -1.32037015957096 1.87647767985755e-18 mirMAP -0.249296693193715 3.02725198543686e-14 NA NA NA hsa-miR-16-5p ABL1 1.75824877145857 1.68592440033108e-16 -1.32037015957096 1.87647767985755e-18 mirMAP -0.310820336280616 3.75259721680265e-21 NA NA NA hsa-miR-19a-3p ABL1 3.42309334186656 3.02671914353412e-28 -1.32037015957096 1.87647767985755e-18 mirMAP -0.162387067627272 2.91974538664916e-13 NA NA NA hsa-miR-200a-3p ABL1 4.59434485520731 6.38952518573476e-18 -1.32037015957096 1.87647767985755e-18 MirTarget -0.148306180031242 1.0002237901953e-31 NA NA NA hsa-miR-26a-2-3p ABL1 0.823520019989974 0.00017092160823769 -1.32037015957096 1.87647767985755e-18 mirMAP -0.152618088179323 1.05762015103927e-05 NA NA NA hsa-miR-29a-5p ABL1 1.46749674755271 3.34605004270294e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.114712372263782 2.92669427439134e-05 NA NA NA hsa-miR-29b-3p ABL1 1.65828197923813 1.02676780888141e-09 -1.32037015957096 1.87647767985755e-18 miRNATAP -0.226156505548727 1.19896226753111e-17 NA NA NA hsa-miR-29c-3p ABL1 -0.00968972577705429 0.97099586346872 -1.32037015957096 1.87647767985755e-18 miRNATAP -0.177447451684939 2.67475171467947e-10 NA NA NA hsa-miR-30b-3p ABL1 0.834142820354026 0.000972582820878813 -1.32037015957096 1.87647767985755e-18 mirMAP -0.152363471011564 3.25049904656188e-07 NA NA NA hsa-miR-30b-5p ABL1 0.800822374912712 0.000133601914525413 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.212394163898943 2.63303999024585e-09 NA NA NA hsa-miR-30c-5p ABL1 0.778774633108 0.000285599212429136 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.242607960634266 2.27192473406919e-12 NA NA NA hsa-miR-30d-5p ABL1 0.675423997639582 0.00270618816039773 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.212422034659354 1.49043808471987e-10 NA NA NA hsa-miR-30e-5p ABL1 1.23904909539663 1.35561917122157e-09 -1.32037015957096 1.87647767985755e-18 MirTarget;miRNATAP -0.3467622622202 2.38742749053345e-23 NA NA NA hsa-miR-3127-5p ABL1 1.51846438737133 3.59571251672767e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.136540309175573 3.72097100552687e-08 NA NA NA hsa-miR-330-5p ABL1 1.15100069700871 4.85551805046014e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.224068027721259 3.32355451679908e-12 NA NA NA hsa-miR-361-5p ABL1 0.971859117235239 5.30236555707088e-09 -1.32037015957096 1.87647767985755e-18 miRanda -0.317700517390337 7.86933437215808e-13 NA NA NA hsa-miR-423-5p ABL1 0.963563145758616 9.86109015204915e-07 -1.32037015957096 1.87647767985755e-18 MirTarget -0.329711312044519 3.9739184786006e-19 NA NA NA hsa-miR-484 ABL1 1.81844463411787 1.82951571230938e-15 -1.32037015957096 1.87647767985755e-18 miRNAWalker2_validate -0.280122803941197 1.14978159043687e-19 NA NA NA hsa-miR-503-5p ABL1 3.66513190181895 6.60300917645278e-21 -1.32037015957096 1.87647767985755e-18 mirMAP -0.148758426639936 3.84030071766847e-15 NA NA NA hsa-let-7d-5p ABL2 1.33236798905207 1.1741085658466e-13 -0.318835189302919 0.0455399452105181 miRNATAP -0.175793650246592 2.72233687814224e-05 NA NA NA hsa-let-7e-5p ABL2 0.860104282510173 6.04758298373779e-05 -0.318835189302919 0.0455399452105181 miRNATAP -0.135744486601333 0.000148370015042221 NA NA NA hsa-let-7g-3p ABL2 3.26398061402445 3.96263126107645e-25 -0.318835189302919 0.0455399452105181 mirMAP -0.118232045742515 4.44236645850463e-07 NA NA NA hsa-let-7g-5p ABL2 1.20061455355116 1.50237505511483e-12 -0.318835189302919 0.0455399452105181 miRNATAP -0.290665961646166 3.49399537394125e-11 NA NA NA hsa-miR-103a-3p ABL2 1.44083190496858 1.53799939616416e-13 -0.318835189302919 0.0455399452105181 miRNAWalker2_validate;MirTarget;miRNATAP -0.186253207823678 1.1786378847727e-06 NA NA NA hsa-miR-106b-5p ABL2 2.46782146831112 1.36171495805632e-23 -0.318835189302919 0.0455399452105181 MirTarget -0.13039856613881 9.57421823908675e-06 NA NA NA hsa-miR-125a-5p ABL2 0.599529391575274 0.0102300147180307 -0.318835189302919 0.0455399452105181 MirTarget;PITA -0.215978868232166 2.65865236229228e-11 26766902 MicroRNA 125a 5p modulates human cervical carcinoma proliferation and migration by targeting ABL2; The direct regulation of miR-125a-5p on its target gene ABL proto-oncogene 2 ABL2 in cervical carcinoma was evaluated by quantitative real-time reverse transcription polymerase chain reaction Western blotting and luciferase reporter assays respectively; ABL2 was shown to be directly targeted by miR-125a-5p; In cervical carcinoma ABL2 gene and protein levels were both downregulated by miR-125a-5p cervical and endocervical cancer hsa-miR-141-3p ABL2 5.02396127982626 2.19224509139725e-24 -0.318835189302919 0.0455399452105181 MirTarget;TargetScan;miRNATAP -0.134399536040292 8.02666476133273e-22 NA NA NA hsa-miR-141-5p ABL2 3.81419396518882 3.21977359736126e-18 -0.318835189302919 0.0455399452105181 MirTarget;miRNATAP -0.145416928103364 1.77743606690844e-19 NA NA NA hsa-miR-15a-5p ABL2 2.34669284378787 1.69544424500258e-23 -0.318835189302919 0.0455399452105181 MirTarget;miRNATAP -0.157263991270179 3.37911953243861e-07 NA NA NA hsa-miR-181c-5p ABL2 1.58587920618301 1.57506918816933e-10 -0.318835189302919 0.0455399452105181 mirMAP -0.130020619380325 1.81822706368131e-05 NA NA NA hsa-miR-182-5p ABL2 3.53923166221814 5.07781258121574e-21 -0.318835189302919 0.0455399452105181 mirMAP -0.142041939712293 6.07073497417664e-14 NA NA NA hsa-miR-186-5p ABL2 1.47445398888668 3.0781726595413e-15 -0.318835189302919 0.0455399452105181 MirTarget;mirMAP -0.112491893349177 0.00520201635156418 NA NA NA hsa-miR-200a-3p ABL2 4.59434485520731 6.38952518573476e-18 -0.318835189302919 0.0455399452105181 MirTarget;miRNATAP -0.137232067823552 6.27391720243776e-26 NA NA NA hsa-miR-200a-5p ABL2 3.86316681673704 1.81076942093171e-15 -0.318835189302919 0.0455399452105181 mirMAP -0.147222330685704 2.17313134863455e-24 NA NA NA hsa-miR-200b-3p ABL2 3.78235093249346 3.18343003239465e-14 -0.318835189302919 0.0455399452105181 MirTarget -0.148088453130948 6.60945856448831e-26 NA NA NA hsa-miR-200b-5p ABL2 2.54484902707822 1.59240467582976e-06 -0.318835189302919 0.0455399452105181 mirMAP -0.132701776735675 1.57631435867731e-17 NA NA NA hsa-miR-200c-3p ABL2 3.50132673580082 2.42716349086937e-15 -0.318835189302919 0.0455399452105181 MirTarget -0.151868587711699 2.33456607871419e-21 NA NA NA hsa-miR-26b-5p ABL2 0.885393662798425 3.2116297961629e-06 -0.318835189302919 0.0455399452105181 MirTarget;miRNATAP -0.164946567675548 4.27307179037643e-05 NA NA NA hsa-miR-27b-3p ABL2 0.196007704287769 0.295630157035388 -0.318835189302919 0.0455399452105181 MirTarget;miRNATAP -0.120418681149021 0.0038171424780741 NA NA NA hsa-miR-29b-2-5p ABL2 0.910668640983475 0.00666655585493488 -0.318835189302919 0.0455399452105181 mirMAP -0.207945149600493 1.71290934807589e-21 NA NA NA hsa-miR-29c-3p ABL2 -0.00968972577705429 0.97099586346872 -0.318835189302919 0.0455399452105181 mirMAP -0.174944738428706 8.83645119870294e-10 NA NA NA hsa-miR-30b-5p ABL2 0.800822374912712 0.000133601914525413 -0.318835189302919 0.0455399452105181 mirMAP -0.179530407826289 8.35780050256629e-07 NA NA NA hsa-miR-30c-5p ABL2 0.778774633108 0.000285599212429136 -0.318835189302919 0.0455399452105181 mirMAP;miRNATAP -0.221968967168904 3.14360773645043e-10 NA NA NA hsa-miR-30d-3p ABL2 0.977747550180601 4.3048212205381e-05 -0.318835189302919 0.0455399452105181 mirMAP -0.18511379063349 5.09648018689475e-09 NA NA NA hsa-miR-30d-5p ABL2 0.675423997639582 0.00270618816039773 -0.318835189302919 0.0455399452105181 mirMAP;miRNATAP -0.205643771066258 1.07003338567436e-09 NA NA NA hsa-miR-30e-3p ABL2 -0.215663037684509 0.235375122783546 -0.318835189302919 0.0455399452105181 mirMAP -0.175288956520667 4.12581513590478e-05 NA NA NA hsa-miR-30e-5p ABL2 1.23904909539663 1.35561917122157e-09 -0.318835189302919 0.0455399452105181 mirMAP -0.270682086571272 7.98501122985411e-14 NA NA NA hsa-miR-34a-3p ABL2 1.75590866103657 8.02801510630657e-09 -0.318835189302919 0.0455399452105181 mirMAP -0.110793958648438 5.76064179434403e-05 NA NA NA hsa-miR-361-5p ABL2 0.971859117235239 5.30236555707088e-09 -0.318835189302919 0.0455399452105181 mirMAP -0.146742010198099 0.00145690849463179 NA NA NA hsa-miR-378a-3p ABL2 -0.10995720000828 0.716188270032681 -0.318835189302919 0.0455399452105181 mirMAP -0.158274112993962 2.72001636315529e-10 NA NA NA hsa-miR-378c ABL2 -0.14996196896414 0.564266703940495 -0.318835189302919 0.0455399452105181 mirMAP -0.122802586533478 3.34624015342161e-05 NA NA NA hsa-miR-429 ABL2 4.48815175680773 2.44117492218206e-17 -0.318835189302919 0.0455399452105181 MirTarget -0.134851292241187 1.27969224490787e-24 NA NA NA hsa-miR-582-3p ABL2 0.00876844181512659 0.977126166214707 -0.318835189302919 0.0455399452105181 PITA -0.119164319375891 1.94736724085761e-06 NA NA NA hsa-miR-769-5p ABL2 1.82023760596845 9.6815886564134e-14 -0.318835189302919 0.0455399452105181 MirTarget -0.106038444203526 0.000534020181300284 NA NA NA hsa-miR-93-5p ABL2 3.03961860136032 1.11672209617395e-24 -0.318835189302919 0.0455399452105181 MirTarget -0.142854535292655 3.29425329900029e-09 NA NA NA hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-3065-5p ANGPT1 2.74629919868982 1.86846589298284e-08 -2.00320848939512 7.51234603738143e-06 mirMAP -0.157963248568316 0.00339143349189613 NA NA NA hsa-miR-335-3p ANGPT1 3.08791651139852 5.31309869723517e-12 -2.00320848939512 7.51234603738143e-06 mirMAP -0.13953242317373 0.00330172430492205 NA NA NA hsa-miR-361-5p ANGPT1 0.971859117235239 5.30236555707088e-09 -2.00320848939512 7.51234603738143e-06 miRanda -0.481765321687889 0.000227292206941834 NA NA NA hsa-miR-429 ANGPT1 4.48815175680773 2.44117492218206e-17 -2.00320848939512 7.51234603738143e-06 miRanda -0.315973268151069 1.29203633929802e-16 NA NA NA hsa-miR-590-3p ANGPT1 2.59289455139753 1.03200520972022e-21 -2.00320848939512 7.51234603738143e-06 PITA;miRanda;mirMAP -0.26744477612574 0.00070073503661837 NA NA NA hsa-miR-944 ANGPT1 2.91186649218281 1.31574753528144e-06 -2.00320848939512 7.51234603738143e-06 PITA;mirMAP -0.161509415342341 1.10510037550753e-05 NA NA NA hsa-miR-142-5p ANGPT2 1.17581605694506 0.0018174701991234 0.162665171077281 0.565563993523621 MirTarget -0.190884775204089 8.65337750704999e-08 NA NA NA hsa-miR-145-5p ANGPT2 -1.55259331973517 9.97889123247165e-07 0.162665171077281 0.565563993523621 MirTarget;miRNATAP -0.171093797478721 5.43701253812128e-05 24384875;27570490 miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer ; kidney renal cell cancer;pancreatic cancer hsa-miR-374b-5p ANGPT2 0.0654362503857184 0.722673188879465 0.162665171077281 0.565563993523621 mirMAP -0.256937248555906 0.000620833356683864 NA NA NA hsa-let-7b-3p BDNF 0.868207752019623 1.30460056774366e-05 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.285067683917082 0.00912745906089909 NA NA NA hsa-miR-103a-3p BDNF 1.44083190496858 1.53799939616416e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.513010583082046 2.18583657796716e-06 NA NA NA hsa-miR-107 BDNF 1.30977326593435 1.30372468603965e-11 -2.90846311399482 3.32327619207597e-11 MirTarget;PITA;miRanda;miRNATAP -0.301411719956826 0.00652496504590489 27498977 MicroRNA 107 inhibits tumor growth and metastasis by targeting the BDNF mediated PI3K/AKT pathway in human non small lung cancer; In addition BDNF expression was upregulated and inversely correlated with miR-107 in NSCLC tissues; Enforced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-107 on NSCLC proliferation migration and invasion; miR-107 overexpression or downregulation of BDNF was able to inhibit activation of PI3K/AKT signaling pathway; Taken together our findings present the first evidence that miR-107 could suppress NSCLC metastasis by targeting BDNF and indirectly regulating PI3K/AKT signaling pathway which might lead to a potential therapeutic strategy focusing on miR-107 and BDNF for human NSCLC metastasis lung cancer hsa-miR-10a-5p BDNF 1.15016989191194 0.00372037233992369 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.239868149823933 9.76923403527126e-06 NA NA NA hsa-miR-15a-5p BDNF 2.34669284378787 1.69544424500258e-23 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.538797123359211 4.53591149420254e-10 26581909 MicroRNA 15a 5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF; BDNF was then overexpressed in HepG2 and SNU-182 cells to evaluate its selective effect on miR-15a-5p in HCC modulation; MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells; Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro; Our study demonstrated that miR-15a-5p is a tumor suppressor in HCC and its regulation is through BDNF in HCC liver cancer hsa-miR-15b-5p BDNF 1.57112623124278 9.14247846750597e-13 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.337417459977062 0.000476250471995874 NA NA NA hsa-miR-16-5p BDNF 1.75824877145857 1.68592440033108e-16 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.404475155904508 3.95284638464173e-05 NA NA NA hsa-miR-182-5p BDNF 3.53923166221814 5.07781258121574e-21 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.304142174368882 2.036484274037e-08 NA NA NA hsa-miR-191-5p BDNF 2.30038190670664 9.93191704545938e-17 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.485298765179322 6.26143603678241e-11 NA NA NA hsa-miR-210-3p BDNF 6.07079758655679 2.22120227133377e-28 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.237223359082858 5.07246234320821e-11 NA NA NA hsa-miR-22-3p BDNF 1.21545661147757 1.61670170137775e-13 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.538030930409075 3.25374878143957e-05 NA NA NA hsa-miR-26b-3p BDNF 2.18464160365372 2.11543189388328e-18 -2.90846311399482 3.32327619207597e-11 MirTarget -0.444310109951697 8.07362790493106e-08 NA NA NA hsa-miR-29b-2-5p BDNF 0.910668640983475 0.00666655585493488 -2.90846311399482 3.32327619207597e-11 mirMAP -0.385323162445974 1.40825527826931e-09 NA NA NA hsa-miR-3065-3p BDNF 2.16221780121195 9.65525739884541e-09 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.207023369564498 0.000246555472230515 NA NA NA hsa-miR-3065-5p BDNF 2.74629919868982 1.86846589298284e-08 -2.90846311399482 3.32327619207597e-11 mirMAP;miRNATAP -0.168376118012365 0.00167095455996276 NA NA NA hsa-miR-30c-5p BDNF 0.778774633108 0.000285599212429136 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.452622492319709 7.0923627825397e-06 NA NA NA hsa-miR-30d-5p BDNF 0.675423997639582 0.00270618816039773 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.31555337460895 0.00110619099852774 NA NA NA hsa-miR-30e-5p BDNF 1.23904909539663 1.35561917122157e-09 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.710933428108993 4.68409714514429e-12 NA NA NA hsa-miR-330-3p BDNF 0.876747334239085 0.00073709016089703 -2.90846311399482 3.32327619207597e-11 MirTarget -0.350307363358734 2.52309207840318e-05 NA NA NA hsa-miR-339-5p BDNF 2.68710938429893 3.03134080808154e-16 -2.90846311399482 3.32327619207597e-11 miRanda -0.208909558420091 0.0010320906387239 NA NA NA hsa-miR-33a-3p BDNF 1.72765312072219 1.51784443453521e-07 -2.90846311399482 3.32327619207597e-11 mirMAP -0.189569900102124 0.00822808887496796 NA NA NA hsa-miR-361-5p BDNF 0.971859117235239 5.30236555707088e-09 -2.90846311399482 3.32327619207597e-11 PITA;miRanda;miRNATAP -0.549614574828476 2.2273701996563e-05 NA NA NA hsa-miR-3913-5p BDNF 2.44353493655328 8.95279496632448e-15 -2.90846311399482 3.32327619207597e-11 mirMAP -0.401161818585588 3.16401389217705e-09 NA NA NA hsa-miR-452-3p BDNF 2.42521958420768 4.08754552781156e-07 -2.90846311399482 3.32327619207597e-11 MirTarget -0.15349375691044 0.000617556235812272 NA NA NA hsa-miR-452-5p BDNF 1.37180058737183 0.00171494843537772 -2.90846311399482 3.32327619207597e-11 miRNATAP -0.159672549433471 0.00121343995890147 NA NA NA hsa-miR-589-3p BDNF 2.51971841868825 2.39125940264107e-11 -2.90846311399482 3.32327619207597e-11 MirTarget -0.19485326256731 0.00234458194019574 NA NA NA hsa-miR-590-3p BDNF 2.59289455139753 1.03200520972022e-21 -2.90846311399482 3.32327619207597e-11 miRanda;mirMAP;miRNATAP -0.215106825481362 0.00623574226190281 NA NA NA hsa-miR-944 BDNF 2.91186649218281 1.31574753528144e-06 -2.90846311399482 3.32327619207597e-11 PITA;mirMAP;miRNATAP -0.210249837446185 6.49747993753151e-09 NA NA NA hsa-let-7a-5p CALM1 0.618599506841644 2.76973453058748e-05 -0.542409877679336 1.23267456304823e-05 TargetScan;miRNATAP -0.177975524153123 1.5514862069122e-05 NA NA NA hsa-let-7d-5p CALM1 1.33236798905207 1.1741085658466e-13 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.211252264558824 6.51721575531856e-11 NA NA NA hsa-let-7e-5p CALM1 0.860104282510173 6.04758298373779e-05 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.106337901256445 0.000148336089225853 NA NA NA hsa-let-7f-5p CALM1 0.495648727272215 0.00355972741198794 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.141971101061974 7.16709801965844e-05 NA NA NA hsa-let-7g-5p CALM1 1.20061455355116 1.50237505511483e-12 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.271649141054462 1.29247797794394e-15 NA NA NA hsa-let-7i-5p CALM1 0.412877696970403 0.00622731051981756 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.141432801006174 0.000499267476050943 NA NA NA hsa-miR-140-3p CALM1 0.0608890720479334 0.727716871248724 -0.542409877679336 1.23267456304823e-05 mirMAP -0.146665546915025 2.58849660330194e-05 NA NA NA hsa-miR-15a-5p CALM1 2.34669284378787 1.69544424500258e-23 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.120071656805105 6.77224071813226e-07 NA NA NA hsa-miR-15b-5p CALM1 1.57112623124278 9.14247846750597e-13 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.186501482609942 1.06760952232274e-12 NA NA NA hsa-miR-16-2-3p CALM1 2.31623086727196 4.29838149388188e-20 -0.542409877679336 1.23267456304823e-05 mirMAP -0.125161698010819 3.03956532705995e-08 NA NA NA hsa-miR-16-5p CALM1 1.75824877145857 1.68592440033108e-16 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.178739472227869 2.83850556432203e-11 NA NA NA hsa-miR-181a-5p CALM1 2.29556023480783 1.8138457900616e-21 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.143106149770854 1.08864398915925e-09 NA NA NA hsa-miR-181b-5p CALM1 2.49307679431293 3.92829250217627e-20 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.113368810038534 6.7959506183487e-08 NA NA NA hsa-miR-181c-5p CALM1 1.58587920618301 1.57506918816933e-10 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.149344276004159 1.92938413416108e-10 NA NA NA hsa-miR-186-5p CALM1 1.47445398888668 3.0781726595413e-15 -0.542409877679336 1.23267456304823e-05 mirMAP -0.24689524309007 5.59885388417673e-16 NA NA NA hsa-miR-193a-3p CALM1 1.60460546928078 2.86169793322984e-07 -0.542409877679336 1.23267456304823e-05 PITA;miRanda;miRNATAP -0.101209592184113 7.51937469119911e-08 NA NA NA hsa-miR-196b-5p CALM1 1.71646270856386 4.37735885910369e-09 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.120604764955469 1.49232204321149e-09 NA NA NA hsa-miR-19a-3p CALM1 3.42309334186656 3.02671914353412e-28 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.113588937629947 1.82233103371982e-10 NA NA NA hsa-miR-19b-3p CALM1 2.49529833021187 1.57028265846699e-23 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.159715716839892 9.44791309661176e-13 NA NA NA hsa-miR-26a-5p CALM1 0.0464832722967259 0.752628386912329 -0.542409877679336 1.23267456304823e-05 mirMAP -0.183048993770801 1.10458039391267e-05 NA NA NA hsa-miR-26b-5p CALM1 0.885393662798425 3.2116297961629e-06 -0.542409877679336 1.23267456304823e-05 mirMAP -0.127161398349145 5.67391080256478e-05 NA NA NA hsa-miR-33a-3p CALM1 1.72765312072219 1.51784443453521e-07 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.106251621653257 6.27575515202382e-08 NA NA NA hsa-miR-362-3p CALM1 2.0756816987665 3.89026064579331e-12 -0.542409877679336 1.23267456304823e-05 miRanda -0.102006708945364 4.03839804018997e-07 NA NA NA hsa-miR-423-5p CALM1 0.963563145758616 9.86109015204915e-07 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.241771028311122 2.73559200052324e-16 NA NA NA hsa-miR-484 CALM1 1.81844463411787 1.82951571230938e-15 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.147560218575401 4.97294163603754e-09 NA NA NA hsa-miR-497-5p CALM1 0.0257087130056286 0.918145413833358 -0.542409877679336 1.23267456304823e-05 miRNATAP -0.128369005291499 8.55541066790267e-08 NA NA NA hsa-miR-505-3p CALM1 1.45322244209148 8.86597629645867e-10 -0.542409877679336 1.23267456304823e-05 mirMAP -0.156408498109134 2.01329111436115e-10 NA NA NA hsa-miR-576-5p CALM1 2.20467023993664 3.4053475193793e-19 -0.542409877679336 1.23267456304823e-05 mirMAP -0.12990517846582 2.18705826032257e-08 NA NA NA hsa-miR-590-3p CALM1 2.59289455139753 1.03200520972022e-21 -0.542409877679336 1.23267456304823e-05 PITA;miRanda;mirMAP;miRNATAP -0.135989648392126 2.06887530992619e-10 NA NA NA hsa-miR-664a-3p CALM1 0.634721925861133 0.00520070178640421 -0.542409877679336 1.23267456304823e-05 mirMAP -0.152959728603622 5.64739267794163e-09 NA NA NA hsa-miR-7-1-3p CALM1 1.84950311431067 1.25300363397654e-13 -0.542409877679336 1.23267456304823e-05 mirMAP -0.134073290636073 7.54283192101662e-09 NA NA NA hsa-miR-598-3p CALM2 0.760968346755936 0.027870939187342 -0.316991801898036 0.0114595074821954 miRNAWalker2_validate -0.135520708941442 1.06167986663314e-15 NA NA NA hsa-miR-27b-3p CALM3 0.196007704287769 0.295630157035388 -0.263120000307818 0.021397203177678 miRNAWalker2_validate;miRNATAP -0.102996061954588 0.00052761268410962 NA NA NA hsa-miR-29b-2-5p CHUK 0.910668640983475 0.00666655585493488 -0.123960303858583 0.302722046952969 MirTarget -0.105463511044412 4.36313837727314e-10 NA NA NA hsa-miR-497-5p CHUK 0.0257087130056286 0.918145413833358 -0.123960303858583 0.302722046952969 MirTarget -0.130303574602807 1.33264117705817e-08 NA NA NA hsa-miR-106a-5p CSF1 2.48882002962836 1.99757727374521e-12 -1.29812834960066 0.000329197071112557 miRNATAP -0.292080056920012 8.20083201848244e-10 NA NA NA hsa-miR-106b-5p CSF1 2.46782146831112 1.36171495805632e-23 -1.29812834960066 0.000329197071112557 miRNATAP -0.69490061470497 7.90243746028848e-28 NA NA NA hsa-miR-107 CSF1 1.30977326593435 1.30372468603965e-11 -1.29812834960066 0.000329197071112557 miRanda -0.65400188460506 6.0908696446948e-14 NA NA NA hsa-miR-125a-5p CSF1 0.599529391575274 0.0102300147180307 -1.29812834960066 0.000329197071112557 mirMAP -0.395599645283962 1.22310594058424e-07 NA NA NA hsa-miR-126-5p CSF1 0.895338176458417 2.33372756450713e-05 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.292616773077932 0.000415105400137839 NA NA NA hsa-miR-128-3p CSF1 1.63756041666078 6.79626586407187e-14 -1.29812834960066 0.000329197071112557 MirTarget -0.50795067112565 4.17877363345535e-11 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 3.5350292994509 1.73934183852569e-27 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.413305363123187 2.44437309944564e-17 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148b-3p CSF1 1.97815018171325 6.07715327281595e-26 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.749968900030656 1.74792992055792e-18 NA NA NA hsa-miR-149-5p CSF1 2.94200492826326 4.93436498919036e-14 -1.29812834960066 0.000329197071112557 MirTarget -0.372531081954126 5.57485802614607e-19 NA NA NA hsa-miR-15a-5p CSF1 2.34669284378787 1.69544424500258e-23 -1.29812834960066 0.000329197071112557 miRNATAP -0.395936347917719 1.71768468421611e-08 NA NA NA hsa-miR-15b-5p CSF1 1.57112623124278 9.14247846750597e-13 -1.29812834960066 0.000329197071112557 miRNATAP -0.454249669515809 3.8631655360902e-09 NA NA NA hsa-miR-16-5p CSF1 1.75824877145857 1.68592440033108e-16 -1.29812834960066 0.000329197071112557 miRNATAP -0.321250773360689 5.51161953303591e-05 NA NA NA hsa-miR-17-5p CSF1 3.2710598467455 9.93128340539455e-27 -1.29812834960066 0.000329197071112557 TargetScan;miRNATAP -0.393432683762314 7.17228463446697e-14 NA NA NA hsa-miR-185-3p CSF1 2.3922478518806 1.3373426768452e-14 -1.29812834960066 0.000329197071112557 MirTarget;mirMAP -0.296012577204368 4.70219904255403e-08 NA NA NA hsa-miR-197-3p CSF1 1.75733174019505 8.88576793100499e-13 -1.29812834960066 0.000329197071112557 MirTarget -0.385769623681918 2.21886851120176e-08 NA NA NA hsa-miR-205-5p CSF1 4.1389800495524 2.05488295686453e-12 -1.29812834960066 0.000329197071112557 MirTarget -0.16200381192512 1.46887787959612e-08 NA NA NA hsa-miR-20a-5p CSF1 3.15577933619191 4.19753346442454e-25 -1.29812834960066 0.000329197071112557 miRNATAP -0.388374611075354 2.29955388371609e-13 NA NA NA hsa-miR-20b-5p CSF1 2.07706563022469 1.10107236083433e-05 -1.29812834960066 0.000329197071112557 miRNATAP -0.21226609801527 4.72517148739017e-09 NA NA NA hsa-miR-27b-3p CSF1 0.196007704287769 0.295630157035388 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.392660450968279 3.33841189043943e-05 NA NA NA hsa-miR-28-5p CSF1 0.230152919654905 0.0742909586754846 -1.29812834960066 0.000329197071112557 miRNATAP -0.482898682197754 0.000591286322752508 NA NA NA hsa-miR-301a-3p CSF1 2.81024345929638 2.29784847962242e-17 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.441964619265934 1.84949991758876e-17 NA NA NA hsa-miR-30b-5p CSF1 0.800822374912712 0.000133601914525413 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.647748467026495 1.76347580346489e-15 NA NA NA hsa-miR-30c-5p CSF1 0.778774633108 0.000285599212429136 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.587084492967281 2.10465961570436e-13 NA NA NA hsa-miR-335-5p CSF1 1.77247705492746 2.22457658872091e-06 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.322452532010456 1.0532896202219e-12 NA NA NA hsa-miR-423-5p CSF1 0.963563145758616 9.86109015204915e-07 -1.29812834960066 0.000329197071112557 miRNATAP -0.771654302751225 1.73604836579277e-19 NA NA NA hsa-miR-429 CSF1 4.48815175680773 2.44117492218206e-17 -1.29812834960066 0.000329197071112557 PITA;miRanda;miRNATAP -0.413388052202471 3.36128581785197e-48 NA NA NA hsa-miR-454-3p CSF1 2.47234127820054 1.12878018736016e-21 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.439709113912521 1.61603625404065e-11 NA NA NA hsa-miR-491-5p CSF1 0.615770352820862 0.0418295628761654 -1.29812834960066 0.000329197071112557 miRanda -0.19854150149161 0.00145414860040171 NA NA NA hsa-miR-505-3p CSF1 1.45322244209148 8.86597629645867e-10 -1.29812834960066 0.000329197071112557 miRNAWalker2_validate -0.311700580263137 1.79723365848452e-05 NA NA NA hsa-miR-532-3p CSF1 1.96631878320218 4.53421954361695e-13 -1.29812834960066 0.000329197071112557 MirTarget;PITA -0.425228567430688 5.43141552036115e-12 NA NA NA hsa-miR-532-5p CSF1 1.55697650978597 1.57884735535196e-11 -1.29812834960066 0.000329197071112557 miRNATAP -0.493295481153669 1.53150016526314e-11 NA NA NA hsa-miR-93-5p CSF1 3.03961860136032 1.11672209617395e-24 -1.29812834960066 0.000329197071112557 miRNATAP -0.577183088546093 4.392495537145e-28 NA NA NA hsa-miR-940 CSF1 3.21011374578759 2.7923171128495e-14 -1.29812834960066 0.000329197071112557 MirTarget;PITA;miRNATAP -0.379143291597792 2.81890189158455e-19 NA NA NA hsa-miR-96-5p CSF1 4.89433085814374 1.92000659886961e-31 -1.29812834960066 0.000329197071112557 miRNATAP -0.428523288509248 7.08622996271483e-31 NA NA NA hsa-miR-107 CSF1R 1.30977326593435 1.30372468603965e-11 -1.04722118455631 0.017969966085107 miRanda -0.894015814449865 2.03071082250236e-17 NA NA NA hsa-miR-339-5p CSF1R 2.68710938429893 3.03134080808154e-16 -1.04722118455631 0.017969966085107 miRanda -0.230136953690785 0.000242843989086468 NA NA NA hsa-miR-34a-5p CSF1R 1.9016323452565 1.43092834643601e-14 -1.04722118455631 0.017969966085107 MirTarget;miRNATAP -0.461603981922354 2.97565476458688e-08 NA NA NA hsa-miR-218-5p EFNA1 -0.573801507392184 0.0551983860126703 1.57576504257657 1.43564310601553e-08 miRNAWalker2_validate -0.209616001114161 3.90667195526562e-06 NA NA NA hsa-miR-145-5p EFNA3 -1.55259331973517 9.97889123247165e-07 1.9208300847997 6.87246410078639e-11 miRNATAP -0.212987435059083 2.25875368357263e-06 NA NA NA hsa-miR-30a-5p EFNA3 -0.878357906436456 0.000509952992366057 1.9208300847997 6.87246410078639e-11 MirTarget;mirMAP;miRNATAP -0.239909917479981 2.83842328485723e-05 NA NA NA hsa-miR-125a-5p EGFR 0.599529391575274 0.0102300147180307 -0.229170429190265 0.593897211976523 mirMAP -0.455142512240812 2.58435389092739e-07 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-140-5p EGFR 0.844753502512594 3.73722278438606e-05 -0.229170429190265 0.593897211976523 miRanda -0.290336016621899 0.00422174515988415 NA NA NA hsa-miR-148b-5p EGFR 2.18024067300781 2.84770452413262e-14 -0.229170429190265 0.593897211976523 mirMAP -0.287604854162764 0.000103760310070035 NA NA NA hsa-miR-186-5p EGFR 1.47445398888668 3.0781726595413e-15 -0.229170429190265 0.593897211976523 mirMAP -0.330064150409367 0.0023537398913317 NA NA NA hsa-miR-200a-3p EGFR 4.59434485520731 6.38952518573476e-18 -0.229170429190265 0.593897211976523 MirTarget -0.167369688006813 6.24721098372953e-06 19671845;26184032 Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells;MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion ;drug resistance;cell migration bladder cancer;lung squamous cell cancer hsa-miR-29b-2-5p EGFR 0.910668640983475 0.00666655585493488 -0.229170429190265 0.593897211976523 mirMAP -0.416042511145117 5.70054998722675e-12 NA NA NA hsa-miR-30d-3p EGFR 0.977747550180601 4.3048212205381e-05 -0.229170429190265 0.593897211976523 mirMAP -0.297777237144485 0.000583685262316395 NA NA NA hsa-miR-362-5p EGFR 1.59303749908759 9.582675908797e-08 -0.229170429190265 0.593897211976523 mirMAP -0.241167685764662 0.00042775566379085 NA NA NA hsa-miR-374a-3p EGFR 0.533309330504947 0.00192918429705142 -0.229170429190265 0.593897211976523 mirMAP -0.472580799180365 0.000102592756227524 NA NA NA hsa-miR-374b-3p EGFR 0.930487774873495 2.74420094310516e-05 -0.229170429190265 0.593897211976523 mirMAP -0.31457186042627 0.000782176493255895 NA NA NA hsa-miR-3913-5p EGFR 2.44353493655328 8.95279496632448e-15 -0.229170429190265 0.593897211976523 mirMAP -0.259753924250973 7.19865795250564e-05 NA NA NA hsa-miR-7-1-3p EGFR 1.84950311431067 1.25300363397654e-13 -0.229170429190265 0.593897211976523 mirMAP -0.211992850385644 0.00900776269242333 NA NA NA hsa-miR-18a-3p EPHA2 2.14813400940323 2.23460809936028e-06 -0.234132006099067 0.472564048282971 MirTarget -0.178224503892159 3.54857111587131e-05 NA NA NA hsa-miR-1180-3p ETS1 1.89089238665533 6.0740017059558e-10 -0.699528618233348 0.00228038287696191 MirTarget -0.244121354774836 2.55157060576529e-12 NA NA NA hsa-miR-130b-5p ETS1 2.9963110846538 1.98883029416455e-18 -0.699528618233348 0.00228038287696191 MirTarget -0.197851115362848 3.09455981925009e-10 NA NA NA hsa-miR-141-3p ETS1 5.02396127982626 2.19224509139725e-24 -0.699528618233348 0.00228038287696191 mirMAP -0.136403222013607 5.63450066135883e-11 NA NA NA hsa-miR-141-5p ETS1 3.81419396518882 3.21977359736126e-18 -0.699528618233348 0.00228038287696191 mirMAP -0.123976156597553 2.49253154344744e-07 NA NA NA hsa-miR-148b-5p ETS1 2.18024067300781 2.84770452413262e-14 -0.699528618233348 0.00228038287696191 MirTarget -0.207990667795076 1.28931361643613e-07 NA NA NA hsa-miR-16-1-3p ETS1 2.56983217111073 3.02262181237943e-20 -0.699528618233348 0.00228038287696191 MirTarget -0.122165585835548 0.00181706646615353 NA NA NA hsa-miR-181c-5p ETS1 1.58587920618301 1.57506918816933e-10 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.175149607451902 6.6152939086479e-05 NA NA NA hsa-miR-181d-5p ETS1 1.52204912185579 9.2693319057748e-08 -0.699528618233348 0.00228038287696191 MirTarget -0.194031987778554 3.77300921536723e-07 NA NA NA hsa-miR-186-5p ETS1 1.47445398888668 3.0781726595413e-15 -0.699528618233348 0.00228038287696191 mirMAP -0.237100721837613 4.18170175987953e-05 NA NA NA hsa-miR-193b-3p ETS1 2.25711804611899 4.1940744806631e-14 -0.699528618233348 0.00228038287696191 miRNAWalker2_validate;miRTarBase -0.116182318208838 0.00128795484233059 20655737 CCND1 and ETS1 were revealed to be regulated by miR-193b directly liver cancer hsa-miR-200a-3p ETS1 4.59434485520731 6.38952518573476e-18 -0.699528618233348 0.00228038287696191 mirMAP -0.130762918379965 2.32449200300814e-11 NA NA NA hsa-miR-200b-3p ETS1 3.78235093249346 3.18343003239465e-14 -0.699528618233348 0.00228038287696191 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.126548351947289 2.52221854075541e-09 NA NA NA hsa-miR-200c-3p ETS1 3.50132673580082 2.42716349086937e-15 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.128822600745719 7.61112410894651e-08 NA NA NA hsa-miR-3065-5p ETS1 2.74629919868982 1.86846589298284e-08 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.193575116122862 4.45006309422286e-13 NA NA NA hsa-miR-30d-3p ETS1 0.977747550180601 4.3048212205381e-05 -0.699528618233348 0.00228038287696191 mirMAP -0.170400392397335 0.000235272019902835 NA NA NA hsa-miR-320b ETS1 1.55692969039548 1.41071034251915e-08 -0.699528618233348 0.00228038287696191 miRanda -0.149437856303236 0.000174923330597169 NA NA NA hsa-miR-34a-3p ETS1 1.75590866103657 8.02801510630657e-09 -0.699528618233348 0.00228038287696191 MirTarget -0.130153884614291 0.00111725955210861 NA NA NA hsa-miR-421 ETS1 1.17791565395543 6.78526676976629e-06 -0.699528618233348 0.00228038287696191 miRanda;mirMAP;miRNATAP -0.172317840126905 4.29884721227258e-05 NA NA NA hsa-miR-429 ETS1 4.48815175680773 2.44117492218206e-17 -0.699528618233348 0.00228038287696191 MirTarget;PITA;miRanda;miRNATAP -0.120719223989231 1.04596955789957e-09 NA NA NA hsa-miR-491-5p ETS1 0.615770352820862 0.0418295628761654 -0.699528618233348 0.00228038287696191 miRanda -0.10782348524909 0.00633079706572199 NA NA NA hsa-miR-501-5p ETS1 1.93654809410041 1.3779381780759e-10 -0.699528618233348 0.00228038287696191 mirMAP -0.139135103900185 0.000174783639360326 NA NA NA hsa-miR-532-3p ETS1 1.96631878320218 4.53421954361695e-13 -0.699528618233348 0.00228038287696191 MirTarget;PITA;miRNATAP -0.199441489908224 4.45954107263149e-07 NA NA NA hsa-miR-576-5p ETS1 2.20467023993664 3.4053475193793e-19 -0.699528618233348 0.00228038287696191 mirMAP -0.130355258248144 0.00265911186248793 NA NA NA hsa-miR-590-5p ETS1 3.18300989862077 2.06813568597893e-26 -0.699528618233348 0.00228038287696191 miRanda -0.158651775088276 8.61652325410999e-06 NA NA NA hsa-miR-660-5p ETS1 1.82692095272076 1.92040083607196e-13 -0.699528618233348 0.00228038287696191 MirTarget -0.134835635879403 0.00199931863083817 NA NA NA hsa-miR-7-1-3p ETS1 1.84950311431067 1.25300363397654e-13 -0.699528618233348 0.00228038287696191 mirMAP -0.139989009171827 0.00125234618495247 NA NA NA hsa-miR-769-5p ETS1 1.82023760596845 9.6815886564134e-14 -0.699528618233348 0.00228038287696191 miRNATAP -0.245118089805823 2.10373211221653e-08 NA NA NA hsa-miR-9-5p ETS1 1.02304182473283 0.042901377604859 -0.699528618233348 0.00228038287696191 miRNAWalker2_validate;miRTarBase;miRNATAP -0.102192436372206 2.67091472704971e-06 NA NA NA hsa-miR-940 ETS1 3.21011374578759 2.7923171128495e-14 -0.699528618233348 0.00228038287696191 MirTarget;miRNATAP -0.149836494354828 5.13213847318185e-08 NA NA NA hsa-miR-942-5p ETS1 2.35195531153712 5.45059325728841e-16 -0.699528618233348 0.00228038287696191 MirTarget -0.100342268781321 0.00675183151347448 NA NA NA hsa-miR-18a-5p ETS2 3.78535678765353 3.72446596213886e-26 -1.33978278379282 1.78431973316623e-07 miRNAWalker2_validate -0.154292970518398 8.70204806082725e-06 NA NA NA hsa-miR-199a-5p ETS2 0.592984035153911 0.0674836634175293 -1.33978278379282 1.78431973316623e-07 miRNAWalker2_validate;miRanda;miRNATAP -0.113844592315077 0.00336927469509143 NA NA NA hsa-miR-218-5p ETS2 -0.573801507392184 0.0551983860126703 -1.33978278379282 1.78431973316623e-07 miRNAWalker2_validate -0.154175341857129 0.000240982614831693 NA NA NA hsa-miR-30e-5p ETS2 1.23904909539663 1.35561917122157e-09 -1.33978278379282 1.78431973316623e-07 mirMAP -0.188803093152032 0.00192543677280458 NA NA NA hsa-miR-340-5p ETS2 0.30282999308409 0.157744789519131 -1.33978278379282 1.78431973316623e-07 mirMAP -0.209684516239737 0.000387240518330015 NA NA NA hsa-miR-450b-5p ETS2 1.69244418548325 1.68064054148881e-10 -1.33978278379282 1.78431973316623e-07 miRNATAP -0.162707760397348 0.000470534837803485 NA NA NA hsa-miR-590-3p ETS2 2.59289455139753 1.03200520972022e-21 -1.33978278379282 1.78431973316623e-07 miRanda -0.134165566521558 0.00319233705355118 NA NA NA hsa-let-7e-5p FASLG 0.860104282510173 6.04758298373779e-05 -0.196180452389551 0.711804379159628 miRNATAP -0.681095573446369 7.73237301751494e-09 NA NA NA hsa-miR-126-5p FGF1 0.895338176458417 2.33372756450713e-05 -0.0184880339301951 0.962515192576832 mirMAP -0.257052884478014 0.00418426830473386 NA NA NA hsa-miR-16-1-3p FGF1 2.56983217111073 3.02262181237943e-20 -0.0184880339301951 0.962515192576832 mirMAP -0.342294668806123 2.38586503825089e-07 NA NA NA hsa-miR-186-5p FGF1 1.47445398888668 3.0781726595413e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.591026951034186 1.46187678760819e-09 NA NA NA hsa-miR-18a-5p FGF1 3.78535678765353 3.72446596213886e-26 -0.0184880339301951 0.962515192576832 MirTarget -0.264847474948657 3.88610261864251e-07 NA NA NA hsa-miR-205-5p FGF1 4.1389800495524 2.05488295686453e-12 -0.0184880339301951 0.962515192576832 mirMAP -0.157775223845845 3.59117960754949e-07 NA NA NA hsa-miR-26b-3p FGF1 2.18464160365372 2.11543189388328e-18 -0.0184880339301951 0.962515192576832 MirTarget -0.423230901828247 4.44177310978311e-09 NA NA NA hsa-miR-320a FGF1 0.438165828017084 0.0390159073347133 -0.0184880339301951 0.962515192576832 miRanda -0.541959251848306 9.85803319868347e-10 NA NA NA hsa-miR-320b FGF1 1.55692969039548 1.41071034251915e-08 -0.0184880339301951 0.962515192576832 miRanda -0.407239237545482 1.30349593223329e-09 NA NA NA hsa-miR-330-5p FGF1 1.15100069700871 4.85551805046014e-07 -0.0184880339301951 0.962515192576832 miRanda;miRNATAP -0.439171157719847 7.15817077978881e-08 NA NA NA hsa-miR-361-5p FGF1 0.971859117235239 5.30236555707088e-09 -0.0184880339301951 0.962515192576832 miRanda -0.85349859964158 1.1628109767779e-14 NA NA NA hsa-miR-3913-5p FGF1 2.44353493655328 8.95279496632448e-15 -0.0184880339301951 0.962515192576832 mirMAP -0.302608268342126 3.69363193887853e-07 NA NA NA hsa-miR-429 FGF1 4.48815175680773 2.44117492218206e-17 -0.0184880339301951 0.962515192576832 miRNATAP -0.267128349292686 9.69262295730924e-16 NA NA NA hsa-miR-484 FGF1 1.81844463411787 1.82951571230938e-15 -0.0184880339301951 0.962515192576832 MirTarget;PITA;miRNATAP -0.394116689453691 8.31708710335926e-07 NA NA NA hsa-miR-532-3p FGF1 1.96631878320218 4.53421954361695e-13 -0.0184880339301951 0.962515192576832 miRNATAP -0.440506181753794 4.21772989420151e-11 NA NA NA hsa-miR-550a-5p FGF1 2.11025227932763 6.94489556637146e-12 -0.0184880339301951 0.962515192576832 MirTarget -0.275012193152473 4.64050292544223e-06 NA NA NA hsa-miR-576-5p FGF1 2.20467023993664 3.4053475193793e-19 -0.0184880339301951 0.962515192576832 PITA;mirMAP -0.300128298067083 4.75057034180223e-05 NA NA NA hsa-miR-590-5p FGF1 3.18300989862077 2.06813568597893e-26 -0.0184880339301951 0.962515192576832 MirTarget;miRanda;miRNATAP -0.343013546630031 1.40984845888558e-08 NA NA NA hsa-miR-944 FGF1 2.91186649218281 1.31574753528144e-06 -0.0184880339301951 0.962515192576832 mirMAP -0.186547406811606 3.74734066850436e-09 NA NA NA hsa-miR-125b-5p FGF11 -1.16462950151259 0.000288900271798384 2.36629832780319 2.81026571264635e-10 mirMAP -0.245248887594589 1.73977327404226e-05 NA NA NA hsa-miR-195-5p FGF11 -1.44753678070504 8.70594292149271e-09 2.36629832780319 2.81026571264635e-10 mirMAP -0.349749547573844 1.22998816790053e-06 NA NA NA hsa-let-7f-1-3p FGF12 1.55054488387679 7.31326775537952e-11 -0.105634203581597 0.830798911418477 MirTarget -0.333111119559479 0.00101034935003356 NA NA NA hsa-miR-29a-5p FGF12 1.46749674755271 3.34605004270294e-07 -0.105634203581597 0.830798911418477 MirTarget -0.321702074213926 0.00020374538956914 NA NA NA hsa-miR-455-5p FGF12 2.2582442061694 1.43472128037398e-13 -0.105634203581597 0.830798911418477 miRanda -0.240066682606252 0.00156512301970859 NA NA NA hsa-let-7a-3p FGF13 1.42015538786275 7.03375209382654e-13 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.476927207954888 9.11116431267741e-08 NA NA NA hsa-let-7b-3p FGF13 0.868207752019623 1.30460056774366e-05 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.330311915944346 0.000291860606001036 NA NA NA hsa-let-7f-1-3p FGF13 1.55054488387679 7.31326775537952e-11 -2.79657067303141 1.56359356599715e-14 MirTarget -0.449044682518558 3.65397965548342e-09 NA NA NA hsa-let-7g-3p FGF13 3.26398061402445 3.96263126107645e-25 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.407085198701305 7.16106489006225e-14 NA NA NA hsa-miR-141-3p FGF13 5.02396127982626 2.19224509139725e-24 -2.79657067303141 1.56359356599715e-14 TargetScan -0.302898746415501 8.87758287571865e-20 NA NA NA hsa-miR-200a-5p FGF13 3.86316681673704 1.81076942093171e-15 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.21982450079845 5.72965300252089e-10 NA NA NA hsa-miR-200b-5p FGF13 2.54484902707822 1.59240467582976e-06 -2.79657067303141 1.56359356599715e-14 MirTarget -0.225797054463804 1.92722376445309e-09 NA NA NA hsa-miR-3065-3p FGF13 2.16221780121195 9.65525739884541e-09 -2.79657067303141 1.56359356599715e-14 MirTarget;miRNATAP -0.190085596758735 5.63840821082238e-05 NA NA NA hsa-miR-3065-5p FGF13 2.74629919868982 1.86846589298284e-08 -2.79657067303141 1.56359356599715e-14 MirTarget;mirMAP;miRNATAP -0.209349645962154 2.57152126823624e-06 NA NA NA hsa-miR-31-3p FGF13 2.70807981248858 8.84479434501203e-05 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.185125316927806 4.97759365271198e-11 NA NA NA hsa-miR-34c-5p FGF13 2.07190852984647 7.35776320806257e-08 -2.79657067303141 1.56359356599715e-14 miRanda -0.174558299761964 0.00042811021121569 NA NA NA hsa-miR-421 FGF13 1.17791565395543 6.78526676976629e-06 -2.79657067303141 1.56359356599715e-14 MirTarget;PITA;miRanda;miRNATAP -0.272548837534654 7.748381820303e-05 NA NA NA hsa-miR-429 FGF13 4.48815175680773 2.44117492218206e-17 -2.79657067303141 1.56359356599715e-14 miRNATAP -0.206395285212018 1.65735860319463e-10 NA NA NA hsa-miR-455-5p FGF13 2.2582442061694 1.43472128037398e-13 -2.79657067303141 1.56359356599715e-14 PITA;miRanda -0.308345140645582 7.0083826972615e-08 NA NA NA hsa-miR-511-5p FGF13 1.04499312543772 0.00234126154508174 -2.79657067303141 1.56359356599715e-14 MirTarget -0.14578918114989 0.00585401970078833 NA NA NA hsa-miR-590-3p FGF13 2.59289455139753 1.03200520972022e-21 -2.79657067303141 1.56359356599715e-14 miRanda -0.50056116303806 4.23454497035437e-15 NA NA NA hsa-miR-7-1-3p FGF13 1.84950311431067 1.25300363397654e-13 -2.79657067303141 1.56359356599715e-14 MirTarget;mirMAP -0.404511369528413 7.64132929406128e-09 NA NA NA hsa-miR-421 FGF14 1.17791565395543 6.78526676976629e-06 -1.46844557178328 0.00268591599153301 miRanda -0.637683195269129 4.6282816865839e-13 NA NA NA hsa-miR-590-3p FGF14 2.59289455139753 1.03200520972022e-21 -1.46844557178328 0.00268591599153301 miRanda -0.549518148621001 6.75806376569127e-11 NA NA NA hsa-miR-96-5p FGF14 4.89433085814374 1.92000659886961e-31 -1.46844557178328 0.00268591599153301 TargetScan -0.32531579054151 7.90142217061031e-10 NA NA NA hsa-miR-103a-3p FGF18 1.44083190496858 1.53799939616416e-13 -1.42483047022124 0.00103718898766565 miRNATAP -0.356068506298048 0.000774817673325315 NA NA NA hsa-miR-107 FGF18 1.30977326593435 1.30372468603965e-11 -1.42483047022124 0.00103718898766565 miRNATAP -0.425066640569775 7.22213089698089e-05 NA NA NA hsa-miR-15a-5p FGF18 2.34669284378787 1.69544424500258e-23 -1.42483047022124 0.00103718898766565 miRNATAP -0.464224982406698 3.74903170207201e-08 NA NA NA hsa-miR-15b-5p FGF18 1.57112623124278 9.14247846750597e-13 -1.42483047022124 0.00103718898766565 miRNATAP -0.618422336678395 1.80376185685917e-11 NA NA NA hsa-miR-16-5p FGF18 1.75824877145857 1.68592440033108e-16 -1.42483047022124 0.00103718898766565 miRNATAP -0.716652518248879 1.53715937075798e-14 NA NA NA hsa-miR-200b-3p FGF18 3.78235093249346 3.18343003239465e-14 -1.42483047022124 0.00103718898766565 TargetScan -0.155406687950871 0.000140098893382056 NA NA NA hsa-miR-200c-3p FGF18 3.50132673580082 2.42716349086937e-15 -1.42483047022124 0.00103718898766565 miRNATAP -0.257330688592158 1.44969551897125e-08 NA NA NA hsa-miR-21-5p FGF18 2.73773305747971 1.38864982139576e-43 -1.42483047022124 0.00103718898766565 miRNATAP -0.441803837579941 4.23160631739167e-06 NA NA NA hsa-miR-330-5p FGF18 1.15100069700871 4.85551805046014e-07 -1.42483047022124 0.00103718898766565 PITA;miRanda;miRNATAP -0.343613128640874 0.000170129552940752 NA NA NA hsa-miR-424-5p FGF18 1.61930224569578 1.89642549274994e-10 -1.42483047022124 0.00103718898766565 miRNATAP -0.26186546069637 0.00131478568853092 NA NA NA hsa-miR-429 FGF18 4.48815175680773 2.44117492218206e-17 -1.42483047022124 0.00103718898766565 miRNATAP -0.135424427434448 0.000379262258909638 NA NA NA hsa-miR-505-3p FGF18 1.45322244209148 8.86597629645867e-10 -1.42483047022124 0.00103718898766565 miRNATAP -0.493018097870616 1.21245467333208e-08 NA NA NA hsa-miR-590-5p FGF18 3.18300989862077 2.06813568597893e-26 -1.42483047022124 0.00103718898766565 miRanda;miRNATAP -0.376932190079452 2.06770613305322e-08 NA NA NA hsa-let-7a-3p FGF2 1.42015538786275 7.03375209382654e-13 -3.45935256477983 3.20406041037898e-17 mirMAP -0.57039623316549 1.64408016446008e-08 NA NA NA hsa-let-7b-3p FGF2 0.868207752019623 1.30460056774366e-05 -3.45935256477983 3.20406041037898e-17 mirMAP -0.530485029047925 2.33230657638534e-07 NA NA NA hsa-let-7f-1-3p FGF2 1.55054488387679 7.31326775537952e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.403619323347166 3.50383349222099e-06 NA NA NA hsa-miR-103a-3p FGF2 1.44083190496858 1.53799939616416e-13 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.951198901738798 5.80167380051094e-22 NA NA NA hsa-miR-107 FGF2 1.30977326593435 1.30372468603965e-11 -3.45935256477983 3.20406041037898e-17 MirTarget;PITA;miRanda;miRNATAP -0.746537045946991 3.12339725479843e-13 NA NA NA hsa-miR-10b-3p FGF2 0.77597971642517 0.00264877454133753 -3.45935256477983 3.20406041037898e-17 mirMAP -0.38765486044307 1.00531657460278e-06 NA NA NA hsa-miR-1226-3p FGF2 1.38118928579963 0.000205503474787488 -3.45935256477983 3.20406041037898e-17 MirTarget -0.406312709645584 4.86442323802081e-11 NA NA NA hsa-miR-144-3p FGF2 0.658119849508907 0.146943823997989 -3.45935256477983 3.20406041037898e-17 MirTarget -0.150660886736508 0.00130127640996876 NA NA NA hsa-miR-148a-5p FGF2 1.16173838132242 0.000148929299881612 -3.45935256477983 3.20406041037898e-17 mirMAP -0.175801486236704 0.00879070967495281 NA NA NA hsa-miR-15a-5p FGF2 2.34669284378787 1.69544424500258e-23 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.8665754259228 1.51865052824555e-28 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 2.33847028227712 4.29662877950836e-19 -3.45935256477983 3.20406041037898e-17 mirMAP -0.698237395560323 2.98047943363042e-22 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.57112623124278 9.14247846750597e-13 -3.45935256477983 3.20406041037898e-17 MirTarget;miRNATAP -0.772339849603923 2.2379572945642e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 2.56983217111073 3.02262181237943e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.706717215195114 8.84760087286705e-25 NA NA NA hsa-miR-16-2-3p FGF2 2.31623086727196 4.29838149388188e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.642959805706348 1.63529117433717e-17 NA NA NA hsa-miR-16-5p FGF2 1.75824877145857 1.68592440033108e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.791482784689716 1.7414135213028e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 2.29556023480783 1.8138457900616e-21 -3.45935256477983 3.20406041037898e-17 mirMAP -0.525450431942733 5.3421915793276e-11 NA NA NA hsa-miR-181b-5p FGF2 2.49307679431293 3.92829250217627e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.487813576366985 7.1537699850524e-12 NA NA NA hsa-miR-181c-5p FGF2 1.58587920618301 1.57506918816933e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.402853563332211 6.66481994248428e-07 NA NA NA hsa-miR-186-5p FGF2 1.47445398888668 3.0781726595413e-15 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate;mirMAP -0.865396245604199 9.71640315277788e-17 NA NA NA hsa-miR-192-5p FGF2 2.69002528723195 1.22990188194432e-16 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.55945113419736 8.27439417486679e-22 NA NA NA hsa-miR-19b-1-5p FGF2 2.57951428759379 4.31576118703427e-20 -3.45935256477983 3.20406041037898e-17 mirMAP -0.684742945615863 1.47856020889472e-23 NA NA NA hsa-miR-200b-3p FGF2 3.78235093249346 3.18343003239465e-14 -3.45935256477983 3.20406041037898e-17 mirMAP -0.442848247331966 6.36624370256829e-33 NA NA NA hsa-miR-200c-3p FGF2 3.50132673580082 2.42716349086937e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.581898672989235 1.2281612826909e-47 NA NA NA hsa-miR-20a-3p FGF2 2.92621109947706 2.49504904635375e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.521338868643764 2.37178789361296e-20 NA NA NA hsa-miR-21-3p FGF2 2.19296355304364 4.63665722759779e-15 -3.45935256477983 3.20406041037898e-17 mirMAP -0.389762818312192 3.3064358783093e-08 NA NA NA hsa-miR-21-5p FGF2 2.73773305747971 1.38864982139576e-43 -3.45935256477983 3.20406041037898e-17 mirMAP -0.590129232102637 2.05709217680526e-10 NA NA NA hsa-miR-215-5p FGF2 2.30755467422978 2.38476032118039e-06 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.234704807386955 3.03139328926694e-08 NA NA NA hsa-miR-32-5p FGF2 2.34056473219422 6.24134585974322e-20 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.528631961245202 2.37324737115731e-12 NA NA NA hsa-miR-330-3p FGF2 0.876747334239085 0.00073709016089703 -3.45935256477983 3.20406041037898e-17 mirMAP -0.408493425882602 1.96553818290449e-07 NA NA NA hsa-miR-335-3p FGF2 3.08791651139852 5.31309869723517e-12 -3.45935256477983 3.20406041037898e-17 mirMAP -0.283343671500426 1.16812423839489e-10 NA NA NA hsa-miR-335-5p FGF2 1.77247705492746 2.22457658872091e-06 -3.45935256477983 3.20406041037898e-17 miRNATAP -0.204481115239778 0.000164239409089154 NA NA NA hsa-miR-361-5p FGF2 0.971859117235239 5.30236555707088e-09 -3.45935256477983 3.20406041037898e-17 mirMAP -1.05676685455326 5.59900406122503e-19 NA NA NA hsa-miR-429 FGF2 4.48815175680773 2.44117492218206e-17 -3.45935256477983 3.20406041037898e-17 mirMAP -0.410445998774638 1.8378122494787e-32 NA NA NA hsa-miR-450b-5p FGF2 1.69244418548325 1.68064054148881e-10 -3.45935256477983 3.20406041037898e-17 mirMAP -0.300742012229277 7.83074250991869e-05 NA NA NA hsa-miR-452-5p FGF2 1.37180058737183 0.00171494843537772 -3.45935256477983 3.20406041037898e-17 mirMAP -0.212195200331281 5.19684741170909e-06 NA NA NA hsa-miR-503-5p FGF2 3.66513190181895 6.60300917645278e-21 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.407288478531313 2.50922381458507e-15 NA NA NA hsa-miR-589-3p FGF2 2.51971841868825 2.39125940264107e-11 -3.45935256477983 3.20406041037898e-17 mirMAP -0.381356804586547 1.66276905891645e-10 NA NA NA hsa-miR-590-3p FGF2 2.59289455139753 1.03200520972022e-21 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.518258185319804 1.08846109843951e-12 NA NA NA hsa-miR-590-5p FGF2 3.18300989862077 2.06813568597893e-26 -3.45935256477983 3.20406041037898e-17 miRanda;mirMAP -0.632565141691195 1.29154238410301e-23 NA NA NA hsa-miR-664a-3p FGF2 0.634721925861133 0.00520070178640421 -3.45935256477983 3.20406041037898e-17 mirMAP -0.355728775133404 9.0166815375644e-05 NA NA NA hsa-miR-92a-3p FGF2 2.06460102658973 1.44784291084757e-19 -3.45935256477983 3.20406041037898e-17 miRNAWalker2_validate -0.899992154982756 2.08015519442665e-28 NA NA NA hsa-miR-93-3p FGF2 2.85383869771942 5.64481766902125e-23 -3.45935256477983 3.20406041037898e-17 mirMAP -0.750363342236745 4.93373884627099e-33 NA NA NA hsa-miR-944 FGF2 2.91186649218281 1.31574753528144e-06 -3.45935256477983 3.20406041037898e-17 MirTarget -0.33196588658737 1.10637179732889e-23 NA NA NA hsa-let-7a-5p FGF5 0.618599506841644 2.76973453058748e-05 0.295109479545415 0.629573395554456 TargetScan -0.91814617286066 5.32530775182813e-06 NA NA NA hsa-miR-16-1-3p FGF5 2.56983217111073 3.02262181237943e-20 0.295109479545415 0.629573395554456 mirMAP -0.338734686460559 0.00113538866111799 NA NA NA hsa-miR-30b-5p FGF5 0.800822374912712 0.000133601914525413 0.295109479545415 0.629573395554456 mirMAP -0.600640883736003 1.90348300406499e-05 NA NA NA hsa-miR-30c-5p FGF5 0.778774633108 0.000285599212429136 0.295109479545415 0.629573395554456 mirMAP -0.92040630911618 9.17796831458907e-12 NA NA NA hsa-miR-30d-5p FGF5 0.675423997639582 0.00270618816039773 0.295109479545415 0.629573395554456 mirMAP -1.13295918526447 3.0017545458782e-19 NA NA NA hsa-miR-30e-5p FGF5 1.23904909539663 1.35561917122157e-09 0.295109479545415 0.629573395554456 mirMAP -1.15649538412346 5.357826498539e-17 NA NA NA hsa-miR-33a-3p FGF5 1.72765312072219 1.51784443453521e-07 0.295109479545415 0.629573395554456 mirMAP -0.539068199759696 2.08072885141182e-08 NA NA NA hsa-miR-3607-3p FGF5 2.68532138541128 5.66716351955047e-14 0.295109479545415 0.629573395554456 miRNATAP -0.234633949263568 0.00441910591787781 NA NA NA hsa-miR-361-5p FGF5 0.971859117235239 5.30236555707088e-09 0.295109479545415 0.629573395554456 miRanda -0.526008521902236 0.00299705315333712 NA NA NA hsa-miR-3913-5p FGF5 2.44353493655328 8.95279496632448e-15 0.295109479545415 0.629573395554456 mirMAP -0.454773813139765 9.34182245565845e-07 NA NA NA hsa-miR-425-5p FGF5 3.07071373939774 4.02947460586085e-25 0.295109479545415 0.629573395554456 mirMAP -0.36043366586368 0.000119548832083508 NA NA NA hsa-miR-582-5p FGF5 0.609226359812689 0.032988717891497 0.295109479545415 0.629573395554456 mirMAP -0.50108445051561 1.06699099148979e-06 NA NA NA hsa-let-7a-3p FGF7 1.42015538786275 7.03375209382654e-13 -3.51313263207438 7.95527572408387e-12 MirTarget;miRNATAP -0.868051763208098 2.15246923266363e-12 NA NA NA hsa-let-7b-3p FGF7 0.868207752019623 1.30460056774366e-05 -3.51313263207438 7.95527572408387e-12 MirTarget;miRNATAP -0.686098645885029 5.95476501085241e-08 NA NA NA hsa-let-7f-1-3p FGF7 1.55054488387679 7.31326775537952e-11 -3.51313263207438 7.95527572408387e-12 MirTarget -0.422294734283416 9.10473994373525e-05 NA NA NA hsa-miR-107 FGF7 1.30977326593435 1.30372468603965e-11 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;miRNATAP -1.33350776374428 6.88980795931608e-28 NA NA NA hsa-miR-125a-3p FGF7 1.24490295132072 5.26925231010328e-06 -3.51313263207438 7.95527572408387e-12 miRanda -0.36428154542973 7.97695913996567e-05 NA NA NA hsa-miR-126-5p FGF7 0.895338176458417 2.33372756450713e-05 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.50607130713236 2.39566802274335e-05 NA NA NA hsa-miR-15a-5p FGF7 2.34669284378787 1.69544424500258e-23 -3.51313263207438 7.95527572408387e-12 miRTarBase;miRNATAP -1.05153766439707 1.95358882887929e-27 NA NA NA hsa-miR-15b-5p FGF7 1.57112623124278 9.14247846750597e-13 -3.51313263207438 7.95527572408387e-12 miRNATAP -1.2675059921588 1.34716750524093e-33 NA NA NA hsa-miR-16-1-3p FGF7 2.56983217111073 3.02262181237943e-20 -3.51313263207438 7.95527572408387e-12 mirMAP -0.962633495741247 1.30046319779539e-30 NA NA NA hsa-miR-16-2-3p FGF7 2.31623086727196 4.29838149388188e-20 -3.51313263207438 7.95527572408387e-12 mirMAP -1.03435039613724 1.94620052074685e-30 NA NA NA hsa-miR-16-5p FGF7 1.75824877145857 1.68592440033108e-16 -3.51313263207438 7.95527572408387e-12 miRNATAP -1.28612319073303 4.51638848249496e-33 NA NA NA hsa-miR-18a-3p FGF7 2.14813400940323 2.23460809936028e-06 -3.51313263207438 7.95527572408387e-12 MirTarget -0.556498884313971 2.26092390202209e-16 NA NA NA hsa-miR-20a-5p FGF7 3.15577933619191 4.19753346442454e-25 -3.51313263207438 7.95527572408387e-12 miRNAWalker2_validate -0.868623781957236 1.39584172420003e-32 NA NA NA hsa-miR-26b-5p FGF7 0.885393662798425 3.2116297961629e-06 -3.51313263207438 7.95527572408387e-12 mirMAP -0.847719846249514 1.19855193491048e-10 NA NA NA hsa-miR-27a-3p FGF7 1.66542180327138 4.93775737894805e-13 -3.51313263207438 7.95527572408387e-12 MirTarget -0.496262584130317 3.80940705649825e-06 NA NA NA hsa-miR-30d-3p FGF7 0.977747550180601 4.3048212205381e-05 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.98464350645187 2.65309361395091e-22 NA NA NA hsa-miR-31-5p FGF7 3.59165123035072 2.27423212057482e-07 -3.51313263207438 7.95527572408387e-12 MirTarget -0.242511081652209 1.15595308501103e-10 NA NA NA hsa-miR-320a FGF7 0.438165828017084 0.0390159073347133 -3.51313263207438 7.95527572408387e-12 miRanda -0.863658740998593 2.38979957240199e-13 NA NA NA hsa-miR-320b FGF7 1.55692969039548 1.41071034251915e-08 -3.51313263207438 7.95527572408387e-12 miRanda -0.8900673002199 8.8221661934298e-25 NA NA NA hsa-miR-33a-3p FGF7 1.72765312072219 1.51784443453521e-07 -3.51313263207438 7.95527572408387e-12 mirMAP -0.869749595956586 2.33649296944708e-28 NA NA NA hsa-miR-3607-3p FGF7 2.68532138541128 5.66716351955047e-14 -3.51313263207438 7.95527572408387e-12 mirMAP -0.64929482323457 8.99724661665848e-22 NA NA NA hsa-miR-361-5p FGF7 0.971859117235239 5.30236555707088e-09 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;miRNATAP -1.56289686557936 1.23555434322998e-27 NA NA NA hsa-miR-374a-3p FGF7 0.533309330504947 0.00192918429705142 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.673095249598969 6.22712424951211e-06 NA NA NA hsa-miR-421 FGF7 1.17791565395543 6.78526676976629e-06 -3.51313263207438 7.95527572408387e-12 miRanda -0.61796765882037 8.36534413441402e-11 NA NA NA hsa-miR-429 FGF7 4.48815175680773 2.44117492218206e-17 -3.51313263207438 7.95527572408387e-12 miRNATAP -0.443581603298994 3.06942783866656e-24 NA NA NA hsa-miR-452-5p FGF7 1.37180058737183 0.00171494843537772 -3.51313263207438 7.95527572408387e-12 mirMAP -0.249611725832981 1.47380993562818e-05 NA NA NA hsa-miR-455-3p FGF7 3.06093594997644 3.54590649799868e-16 -3.51313263207438 7.95527572408387e-12 PITA;miRNATAP -0.607725997000264 1.53851303208614e-22 NA NA NA hsa-miR-484 FGF7 1.81844463411787 1.82951571230938e-15 -3.51313263207438 7.95527572408387e-12 PITA -0.960272098641967 1.85266514198687e-20 NA NA NA hsa-miR-486-5p FGF7 -0.194913133034028 0.607377798807705 -3.51313263207438 7.95527572408387e-12 MirTarget;miRanda -0.350475600632684 1.38246507581354e-07 NA NA NA hsa-miR-501-5p FGF7 1.93654809410041 1.3779381780759e-10 -3.51313263207438 7.95527572408387e-12 PITA;mirMAP -0.377449765945373 8.38821662648711e-06 NA NA NA hsa-miR-582-3p FGF7 0.00876844181512659 0.977126166214707 -3.51313263207438 7.95527572408387e-12 PITA;miRNATAP -0.444512234576302 7.58144669390707e-08 NA NA NA hsa-miR-590-3p FGF7 2.59289455139753 1.03200520972022e-21 -3.51313263207438 7.95527572408387e-12 PITA;miRanda;mirMAP;miRNATAP -0.837742801847946 1.56917534011074e-21 NA NA NA hsa-miR-590-5p FGF7 3.18300989862077 2.06813568597893e-26 -3.51313263207438 7.95527572408387e-12 PITA;miRanda -0.82452421363643 1.87090418897067e-26 NA NA NA hsa-miR-7-1-3p FGF7 1.84950311431067 1.25300363397654e-13 -3.51313263207438 7.95527572408387e-12 mirMAP -0.853688804833789 4.05730521370535e-19 NA NA NA hsa-miR-944 FGF7 2.91186649218281 1.31574753528144e-06 -3.51313263207438 7.95527572408387e-12 mirMAP -0.392489693630891 1.34607680998663e-21 NA NA NA hsa-miR-142-3p FGF9 2.75247908790621 1.45636065474764e-12 -4.26095125698269 8.03301928631002e-16 miRanda -0.304602080556944 3.74420488921244e-06 NA NA NA hsa-miR-142-5p FGF9 1.17581605694506 0.0018174701991234 -4.26095125698269 8.03301928631002e-16 mirMAP -0.238268156517486 0.000658901150979571 NA NA NA hsa-miR-15a-5p FGF9 2.34669284378787 1.69544424500258e-23 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.613515930639976 6.81151068408031e-09 NA NA NA hsa-miR-15b-5p FGF9 1.57112623124278 9.14247846750597e-13 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.802569271834457 3.63021724126861e-12 NA NA NA hsa-miR-16-2-3p FGF9 2.31623086727196 4.29838149388188e-20 -4.26095125698269 8.03301928631002e-16 mirMAP -0.800367524866385 2.04134354031929e-16 NA NA NA hsa-miR-16-5p FGF9 1.75824877145857 1.68592440033108e-16 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.883505660298818 5.27035859785824e-14 NA NA NA hsa-miR-181a-5p FGF9 2.29556023480783 1.8138457900616e-21 -4.26095125698269 8.03301928631002e-16 mirMAP -0.489899182058424 2.6269594131992e-06 NA NA NA hsa-miR-181b-5p FGF9 2.49307679431293 3.92829250217627e-20 -4.26095125698269 8.03301928631002e-16 mirMAP -0.508260400727932 3.82554365417734e-08 NA NA NA hsa-miR-182-5p FGF9 3.53923166221814 5.07781258121574e-21 -4.26095125698269 8.03301928631002e-16 miRTarBase;miRNATAP -0.199763187583912 0.00291090860779188 NA NA NA hsa-miR-183-5p FGF9 4.19757025992371 4.79612296318304e-26 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.247497021287039 7.27398434498139e-05 NA NA NA hsa-miR-186-5p FGF9 1.47445398888668 3.0781726595413e-15 -4.26095125698269 8.03301928631002e-16 mirMAP -0.699532502904695 3.5394259788128e-07 NA NA NA hsa-miR-205-5p FGF9 4.1389800495524 2.05488295686453e-12 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.326036683952424 1.66736877723578e-14 NA NA NA hsa-miR-212-3p FGF9 0.357878936470387 0.232446214501331 -4.26095125698269 8.03301928631002e-16 mirMAP -0.242923523642108 0.00659695119245421 NA NA NA hsa-miR-26b-5p FGF9 0.885393662798425 3.2116297961629e-06 -4.26095125698269 8.03301928631002e-16 miRNAWalker2_validate -0.463461132249546 0.00089179354119325 NA NA NA hsa-miR-32-3p FGF9 2.02436999565685 5.94091197945307e-09 -4.26095125698269 8.03301928631002e-16 mirMAP -0.424513773785253 5.42028936260741e-07 NA NA NA hsa-miR-320b FGF9 1.55692969039548 1.41071034251915e-08 -4.26095125698269 8.03301928631002e-16 mirMAP;miRNATAP -0.355538591217071 0.000183486822496139 NA NA NA hsa-miR-330-5p FGF9 1.15100069700871 4.85551805046014e-07 -4.26095125698269 8.03301928631002e-16 miRanda;miRNATAP -0.423366003580199 0.000230055048357782 NA NA NA hsa-miR-3607-3p FGF9 2.68532138541128 5.66716351955047e-14 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.24313494691515 0.000999639918173201 NA NA NA hsa-miR-424-5p FGF9 1.61930224569578 1.89642549274994e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.58737553539275 6.18032575679243e-09 NA NA NA hsa-miR-450b-5p FGF9 1.69244418548325 1.68064054148881e-10 -4.26095125698269 8.03301928631002e-16 mirMAP;miRNATAP -0.340701382488691 0.000517592246201871 NA NA NA hsa-miR-455-5p FGF9 2.2582442061694 1.43472128037398e-13 -4.26095125698269 8.03301928631002e-16 miRanda -0.514569349219032 5.600682082645e-10 NA NA NA hsa-miR-500a-5p FGF9 1.72110365584658 3.0807246212659e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.305215850049758 0.00136645365694185 NA NA NA hsa-miR-501-3p FGF9 1.83132758513743 1.10971547702065e-10 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.275213501706133 0.00266614535053256 NA NA NA hsa-miR-502-3p FGF9 1.50560877085049 1.2647489756373e-11 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.472515714777411 5.16045988653371e-05 NA NA NA hsa-miR-590-3p FGF9 2.59289455139753 1.03200520972022e-21 -4.26095125698269 8.03301928631002e-16 miRanda;mirMAP -0.634218650148273 1.44459862312323e-11 NA NA NA hsa-miR-590-5p FGF9 3.18300989862077 2.06813568597893e-26 -4.26095125698269 8.03301928631002e-16 miRanda -0.585459859087567 2.600352130665e-12 NA NA NA hsa-miR-744-3p FGF9 2.7517405670917 4.22040908411227e-14 -4.26095125698269 8.03301928631002e-16 miRNATAP -0.478257215030822 4.08425547781364e-12 NA NA NA hsa-miR-944 FGF9 2.91186649218281 1.31574753528144e-06 -4.26095125698269 8.03301928631002e-16 mirMAP -0.299847632396488 8.53539059567662e-12 NA NA NA hsa-miR-96-5p FGF9 4.89433085814374 1.92000659886961e-31 -4.26095125698269 8.03301928631002e-16 TargetScan;miRNATAP -0.27635466915326 3.67018504641498e-06 NA NA NA hsa-miR-106a-5p FGFR1 2.48882002962836 1.99757727374521e-12 -2.87837421637657 3.11921581471297e-13 mirMAP -0.384049482399962 3.23721514703937e-13 NA NA NA hsa-miR-106b-5p FGFR1 2.46782146831112 1.36171495805632e-23 -2.87837421637657 3.11921581471297e-13 mirMAP -0.786989656536899 1.34893666834924e-28 NA NA NA hsa-miR-10a-5p FGFR1 1.15016989191194 0.00372037233992369 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.337275460563786 2.76715914740678e-12 21738581 Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated pancreatic cancer hsa-miR-135b-5p FGFR1 3.62510365056501 1.09148980810091e-10 -2.87837421637657 3.11921581471297e-13 mirMAP -0.256448226944969 3.75332453789719e-13 NA NA NA hsa-miR-15a-5p FGFR1 2.34669284378787 1.69544424500258e-23 -2.87837421637657 3.11921581471297e-13 miRNATAP -0.754714476564242 1.61012864706111e-23 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 1.57112623124278 9.14247846750597e-13 -2.87837421637657 3.11921581471297e-13 miRNATAP -0.775708333138364 1.99211850175655e-20 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 1.75824877145857 1.68592440033108e-16 -2.87837421637657 3.11921581471297e-13 miRTarBase;miRNATAP -0.872588788016778 5.80543636431341e-25 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 3.2710598467455 9.93128340539455e-27 -2.87837421637657 3.11921581471297e-13 mirMAP -0.561714096530076 1.45885352023962e-22 NA NA NA hsa-miR-181b-5p FGFR1 2.49307679431293 3.92829250217627e-20 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.302065593540415 1.18303842029487e-05 NA NA NA hsa-miR-200a-5p FGFR1 3.86316681673704 1.81076942093171e-15 -2.87837421637657 3.11921581471297e-13 mirMAP -0.445799640285698 2.0477017707227e-35 NA NA NA hsa-miR-200b-5p FGFR1 2.54484902707822 1.59240467582976e-06 -2.87837421637657 3.11921581471297e-13 mirMAP -0.423363595037777 9.00824115860094e-28 NA NA NA hsa-miR-20a-5p FGFR1 3.15577933619191 4.19753346442454e-25 -2.87837421637657 3.11921581471297e-13 mirMAP -0.555458710370069 9.61690870294644e-22 NA NA NA hsa-miR-20b-5p FGFR1 2.07706563022469 1.10107236083433e-05 -2.87837421637657 3.11921581471297e-13 mirMAP -0.209937819299542 2.53129403166548e-07 NA NA NA hsa-miR-301a-3p FGFR1 2.81024345929638 2.29784847962242e-17 -2.87837421637657 3.11921581471297e-13 mirMAP -0.457918632801525 5.01605114375097e-15 NA NA NA hsa-miR-3065-5p FGFR1 2.74629919868982 1.86846589298284e-08 -2.87837421637657 3.11921581471297e-13 mirMAP -0.223732992343918 3.37250597920076e-06 NA NA NA hsa-miR-330-3p FGFR1 0.876747334239085 0.00073709016089703 -2.87837421637657 3.11921581471297e-13 PITA;miRNATAP -0.559474382786579 2.73100688103047e-14 NA NA NA hsa-miR-330-5p FGFR1 1.15100069700871 4.85551805046014e-07 -2.87837421637657 3.11921581471297e-13 miRanda;miRNATAP -0.598697666333084 6.64556149251227e-13 NA NA NA hsa-miR-335-3p FGFR1 3.08791651139852 5.31309869723517e-12 -2.87837421637657 3.11921581471297e-13 mirMAP -0.228197239098805 6.49231469692864e-08 NA NA NA hsa-miR-361-5p FGFR1 0.971859117235239 5.30236555707088e-09 -2.87837421637657 3.11921581471297e-13 miRanda -0.92653502351532 4.53500138468749e-16 NA NA NA hsa-miR-455-5p FGFR1 2.2582442061694 1.43472128037398e-13 -2.87837421637657 3.11921581471297e-13 miRanda -0.195533414771426 0.00177055042135951 NA NA NA hsa-miR-532-5p FGFR1 1.55697650978597 1.57884735535196e-11 -2.87837421637657 3.11921581471297e-13 PITA -0.322395452372313 0.000108234147627559 NA NA NA hsa-miR-590-3p FGFR1 2.59289455139753 1.03200520972022e-21 -2.87837421637657 3.11921581471297e-13 miRanda;mirMAP -0.57572040519455 4.81539975802524e-17 NA NA NA hsa-miR-744-5p FGFR1 1.48254348878737 3.23019501613577e-09 -2.87837421637657 3.11921581471297e-13 miRNAWalker2_validate -0.538473651654813 1.02221972010418e-12 NA NA NA hsa-miR-93-5p FGFR1 3.03961860136032 1.11672209617395e-24 -2.87837421637657 3.11921581471297e-13 mirMAP -0.600996333108956 4.3413966207049e-24 NA NA NA hsa-let-7a-3p FGFR2 1.42015538786275 7.03375209382654e-13 -1.10510536599184 0.0128825317606034 miRNATAP -0.403668699840633 0.000151473399712384 NA NA NA hsa-let-7b-3p FGFR2 0.868207752019623 1.30460056774366e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.309687251123528 0.00423048135274253 NA NA NA hsa-miR-107 FGFR2 1.30977326593435 1.30372468603965e-11 -1.10510536599184 0.0128825317606034 PITA;miRanda -0.398153526215925 0.00027439034373613 NA NA NA hsa-miR-126-5p FGFR2 0.895338176458417 2.33372756450713e-05 -1.10510536599184 0.0128825317606034 mirMAP;miRNATAP -0.403452572621652 6.82252178653857e-05 NA NA NA hsa-miR-186-5p FGFR2 1.47445398888668 3.0781726595413e-15 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate -0.471854892718397 2.53033898213571e-05 NA NA NA hsa-miR-193a-3p FGFR2 1.60460546928078 2.86169793322984e-07 -1.10510536599184 0.0128825317606034 miRanda -0.184992348766107 0.00659604280779591 NA NA NA hsa-miR-19b-1-5p FGFR2 2.57951428759379 4.31576118703427e-20 -1.10510536599184 0.0128825317606034 miRNAWalker2_validate;miRTarBase -0.4345309219133 4.77765562006864e-09 NA NA NA hsa-miR-324-5p FGFR2 2.95683728155095 1.32960514360912e-20 -1.10510536599184 0.0128825317606034 miRanda -0.24680525694008 0.000127710806173706 NA NA NA hsa-miR-338-3p FGFR2 0.453166438193782 0.144583389707558 -1.10510536599184 0.0128825317606034 miRanda;miRNATAP -0.263518769420772 0.000141261313872914 NA NA NA hsa-miR-423-3p FGFR2 2.57855385753676 9.19765570228097e-24 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.233949308012158 0.00330874395567353 NA NA NA hsa-miR-590-3p FGFR2 2.59289455139753 1.03200520972022e-21 -1.10510536599184 0.0128825317606034 miRanda -0.311141579023723 6.00872154446622e-05 NA NA NA hsa-miR-628-5p FGFR2 0.799263053510813 2.28892357418044e-05 -1.10510536599184 0.0128825317606034 PITA;miRNATAP -0.568329203893148 5.54144600332728e-07 NA NA NA hsa-miR-100-5p FGFR3 -1.48442967087177 1.5610956769298e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.39236626068709 3.31966324164684e-05 23778527;25344675;26604796;26018508 Hypoxia regulates FGFR3 expression via HIF 1Ī± and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress;MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3 poor survival;;; bladder cancer;pancreatic cancer;glioblastoma;sarcoma hsa-miR-142-3p FGFR3 2.75247908790621 1.45636065474764e-12 1.15552976289114 0.0896174662454542 miRanda -0.216798137380456 0.00854904538212289 NA NA NA hsa-miR-99a-5p FGFR3 -1.90541207788117 1.19082238183432e-05 1.15552976289114 0.0896174662454542 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.278809233789285 0.00018764039323491 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-146b-5p FLT1 1.75587235896724 1.15724631266659e-07 -0.398798139585047 0.102684609418445 miRanda -0.159935179058735 4.56535177014795e-06 NA NA NA hsa-miR-155-5p FLT1 1.20164021433135 0.00086170622431261 -0.398798139585047 0.102684609418445 miRNAWalker2_validate;mirMAP -0.124036074181 0.000133378861297828 NA NA NA hsa-miR-19a-3p FLT1 3.42309334186656 3.02671914353412e-28 -0.398798139585047 0.102684609418445 MirTarget -0.142945164779521 5.3933264147706e-05 NA NA NA hsa-miR-19b-3p FLT1 2.49529833021187 1.57028265846699e-23 -0.398798139585047 0.102684609418445 MirTarget -0.181991444657249 4.7083327417296e-05 NA NA NA hsa-miR-29a-5p FLT1 1.46749674755271 3.34605004270294e-07 -0.398798139585047 0.102684609418445 MirTarget -0.124373949621283 0.00379603474183942 NA NA NA hsa-miR-339-5p FLT1 2.68710938429893 3.03134080808154e-16 -0.398798139585047 0.102684609418445 miRanda -0.173745122508606 4.02337703117215e-07 NA NA NA hsa-miR-590-3p FLT1 2.59289455139753 1.03200520972022e-21 -0.398798139585047 0.102684609418445 miRanda -0.132919196101858 0.00184001108177259 NA NA NA hsa-miR-125a-5p FLT3 0.599529391575274 0.0102300147180307 -1.96802952624864 2.65981345780205e-05 miRanda -0.263480704467921 0.0074248734779586 NA NA NA hsa-miR-491-5p FLT3 0.615770352820862 0.0418295628761654 -1.96802952624864 2.65981345780205e-05 miRanda -0.22212906907477 0.00622648817980623 NA NA NA hsa-miR-491-5p FLT3LG 0.615770352820862 0.0418295628761654 -0.470988803938591 0.0537610955077815 miRanda -0.119840680493133 0.00424846672478406 NA NA NA hsa-miR-331-3p FLT4 2.28379581858927 1.99663919173155e-18 -0.514633942951051 0.0469674197809773 miRNAWalker2_validate -0.146482440615543 0.0015099115945375 NA NA NA hsa-miR-1271-5p FOXO4 0.970418832993172 0.000609742584380688 -0.591821097168406 0.00243866906660027 MirTarget -0.174288178214226 1.33675311855339e-07 NA NA NA hsa-miR-142-3p FOXO4 2.75247908790621 1.45636065474764e-12 -0.591821097168406 0.00243866906660027 MirTarget;miRanda;miRNATAP -0.144942669119301 4.50437866762796e-10 NA NA NA hsa-miR-2355-5p FOXO4 1.32510310704724 8.25139516692683e-07 -0.591821097168406 0.00243866906660027 MirTarget -0.25892248569406 2.16074953558504e-14 NA NA NA hsa-miR-23a-3p FOXO4 1.00493340843378 2.55313889288924e-08 -0.591821097168406 0.00243866906660027 miRNATAP -0.269190510461252 1.94786834179725e-07 NA NA NA hsa-miR-29a-3p FOXO4 -0.35074463683376 0.161238718982428 -0.591821097168406 0.00243866906660027 miRNATAP -0.164279310869556 1.36859260879512e-05 NA NA NA hsa-miR-29b-3p FOXO4 1.65828197923813 1.02676780888141e-09 -0.591821097168406 0.00243866906660027 miRNATAP -0.120809096201218 0.000409245652270076 NA NA NA hsa-miR-339-5p FOXO4 2.68710938429893 3.03134080808154e-16 -0.591821097168406 0.00243866906660027 miRanda -0.119178054190011 1.56485715716644e-05 NA NA NA hsa-miR-34c-5p FOXO4 2.07190852984647 7.35776320806257e-08 -0.591821097168406 0.00243866906660027 miRanda -0.116152901653273 5.98071754883589e-06 NA NA NA hsa-miR-361-3p FOXO4 1.07367425434318 1.73142774168958e-09 -0.591821097168406 0.00243866906660027 mirMAP -0.172701211064981 0.00104962898156544 NA NA NA hsa-miR-590-5p FOXO4 3.18300989862077 2.06813568597893e-26 -0.591821097168406 0.00243866906660027 miRanda -0.112692327244602 0.000215511631706302 NA NA NA hsa-let-7a-3p GAB1 1.42015538786275 7.03375209382654e-13 -0.893753640154927 1.35889350853124e-06 mirMAP -0.184763675718885 3.49224252384362e-05 NA NA NA hsa-miR-106b-5p GAB1 2.46782146831112 1.36171495805632e-23 -0.893753640154927 1.35889350853124e-06 MirTarget;miRNATAP -0.165226506831855 1.71803876668693e-06 NA NA NA hsa-miR-126-5p GAB1 0.895338176458417 2.33372756450713e-05 -0.893753640154927 1.35889350853124e-06 mirMAP -0.16099794153512 0.000154833130896551 NA NA NA hsa-miR-141-5p GAB1 3.81419396518882 3.21977359736126e-18 -0.893753640154927 1.35889350853124e-06 MirTarget -0.102114902417508 1.70498877262176e-07 NA NA NA hsa-miR-15b-3p GAB1 2.33847028227712 4.29662877950836e-19 -0.893753640154927 1.35889350853124e-06 mirMAP -0.171862478461677 1.56555784967803e-07 NA NA NA hsa-miR-16-1-3p GAB1 2.56983217111073 3.02262181237943e-20 -0.893753640154927 1.35889350853124e-06 mirMAP -0.182123955970364 6.61471908782953e-09 NA NA NA hsa-miR-17-5p GAB1 3.2710598467455 9.93128340539455e-27 -0.893753640154927 1.35889350853124e-06 MirTarget;TargetScan;miRNATAP -0.139921537727459 3.60594188489862e-07 NA NA NA hsa-miR-186-5p GAB1 1.47445398888668 3.0781726595413e-15 -0.893753640154927 1.35889350853124e-06 mirMAP -0.217521224164674 3.53582575186035e-06 NA NA NA hsa-miR-18a-5p GAB1 3.78535678765353 3.72446596213886e-26 -0.893753640154927 1.35889350853124e-06 MirTarget;miRNATAP -0.110960935998339 8.49682858039571e-06 NA NA NA hsa-miR-20a-5p GAB1 3.15577933619191 4.19753346442454e-25 -0.893753640154927 1.35889350853124e-06 MirTarget;miRNATAP -0.148522068768465 7.64210049991874e-08 NA NA NA hsa-miR-27a-3p GAB1 1.66542180327138 4.93775737894805e-13 -0.893753640154927 1.35889350853124e-06 MirTarget;miRNATAP -0.100303487994634 0.00898874845768981 NA NA NA hsa-miR-29b-3p GAB1 1.65828197923813 1.02676780888141e-09 -0.893753640154927 1.35889350853124e-06 MirTarget -0.149788858946879 4.00017062242626e-06 NA NA NA hsa-miR-30c-5p GAB1 0.778774633108 0.000285599212429136 -0.893753640154927 1.35889350853124e-06 mirMAP -0.169248461375016 5.61927576863585e-05 NA NA NA hsa-miR-30e-5p GAB1 1.23904909539663 1.35561917122157e-09 -0.893753640154927 1.35889350853124e-06 mirMAP -0.136496350425296 0.00179857624279159 NA NA NA hsa-miR-34a-5p GAB1 1.9016323452565 1.43092834643601e-14 -0.893753640154927 1.35889350853124e-06 MirTarget -0.188182529050272 8.58822853873461e-08 NA NA NA hsa-miR-374a-3p GAB1 0.533309330504947 0.00192918429705142 -0.893753640154927 1.35889350853124e-06 mirMAP -0.256348166549396 1.15222017095123e-06 NA NA NA hsa-miR-590-3p GAB1 2.59289455139753 1.03200520972022e-21 -0.893753640154927 1.35889350853124e-06 miRanda;mirMAP -0.138313242517517 2.08927589852999e-05 NA NA NA hsa-miR-664a-3p GAB1 0.634721925861133 0.00520070178640421 -0.893753640154927 1.35889350853124e-06 MirTarget -0.151093634134545 0.000147943409900301 NA NA NA hsa-miR-7-1-3p GAB1 1.84950311431067 1.25300363397654e-13 -0.893753640154927 1.35889350853124e-06 mirMAP -0.172861898386465 7.7256260575804e-07 NA NA NA hsa-miR-93-5p GAB1 3.03961860136032 1.11672209617395e-24 -0.893753640154927 1.35889350853124e-06 MirTarget;miRNATAP -0.176921063184285 4.04154176281865e-10 NA NA NA hsa-let-7a-5p GAB2 0.618599506841644 2.76973453058748e-05 -1.20165054399091 1.06247685933273e-06 MirTarget;TargetScan -0.357573556241525 1.39838997260434e-05 NA NA NA hsa-let-7b-5p GAB2 0.604314269683977 0.00140009936153214 -1.20165054399091 1.06247685933273e-06 MirTarget -0.353706021483345 2.34993521339492e-08 NA NA NA hsa-miR-125a-5p GAB2 0.599529391575274 0.0102300147180307 -1.20165054399091 1.06247685933273e-06 mirMAP -0.160573109900683 0.00193225961010046 NA NA NA hsa-miR-141-3p GAB2 5.02396127982626 2.19224509139725e-24 -1.20165054399091 1.06247685933273e-06 mirMAP -0.132797466896447 4.66744464034186e-09 NA NA NA hsa-miR-181b-5p GAB2 2.49307679431293 3.92829250217627e-20 -1.20165054399091 1.06247685933273e-06 mirMAP -0.109686763757945 0.00994169370576225 NA NA NA hsa-miR-1976 GAB2 2.06550563678192 7.81396978619772e-18 -1.20165054399091 1.06247685933273e-06 MirTarget -0.235371396894446 9.254335969367e-07 NA NA NA hsa-miR-3607-3p GAB2 2.68532138541128 5.66716351955047e-14 -1.20165054399091 1.06247685933273e-06 mirMAP -0.160627057919977 1.40800017264093e-06 NA NA NA hsa-miR-452-3p GAB2 2.42521958420768 4.08754552781156e-07 -1.20165054399091 1.06247685933273e-06 mirMAP -0.123065941254776 6.02909421106142e-07 NA NA NA hsa-miR-590-3p GAB2 2.59289455139753 1.03200520972022e-21 -1.20165054399091 1.06247685933273e-06 PITA;miRanda -0.152659316476713 0.000445614457379914 NA NA NA hsa-miR-629-3p GAB2 2.36570947321815 1.33458201201618e-11 -1.20165054399091 1.06247685933273e-06 mirMAP -0.142089868961058 0.000178856579583923 NA NA NA hsa-miR-664a-5p GAB2 0.505019913598436 0.032933350691651 -1.20165054399091 1.06247685933273e-06 mirMAP -0.153941567171422 0.00270434678960611 NA NA NA hsa-miR-101-3p GNB1 0.522819989585461 0.00375627731618038 0.0801691781103262 0.384843432128372 miRNAWalker2_validate;MirTarget;miRNATAP -0.13589850334445 2.52565267772536e-08 NA NA NA hsa-miR-103a-2-5p GNB4 2.47599305985086 7.933028987326e-11 -0.637235835846949 0.0637787413436148 MirTarget -0.208044825181209 1.48817111909234e-05 NA NA NA hsa-miR-186-5p GNB4 1.47445398888668 3.0781726595413e-15 -0.637235835846949 0.0637787413436148 MirTarget -0.425008340793968 8.11370178730736e-07 NA NA NA hsa-miR-203a-3p GNB4 3.12352008343999 9.49391438647189e-07 -0.637235835846949 0.0637787413436148 MirTarget -0.111293242469192 1.31643864940443e-05 NA NA NA hsa-miR-23b-3p GNB4 -0.251132426825047 0.150200321210792 -0.637235835846949 0.0637787413436148 mirMAP -0.432382465446317 6.85322291224931e-06 NA NA NA hsa-miR-29b-3p GNB4 1.65828197923813 1.02676780888141e-09 -0.637235835846949 0.0637787413436148 MirTarget -0.237099869786872 7.67615650269402e-05 NA NA NA hsa-miR-29c-3p GNB4 -0.00968972577705429 0.97099586346872 -0.637235835846949 0.0637787413436148 miRNAWalker2_validate;MirTarget -0.533878931428651 7.81676803580413e-19 NA NA NA hsa-miR-3065-5p GNB4 2.74629919868982 1.86846589298284e-08 -0.637235835846949 0.0637787413436148 mirMAP -0.120245985176494 0.00337512624646212 NA NA NA hsa-miR-33a-3p GNB4 1.72765312072219 1.51784443453521e-07 -0.637235835846949 0.0637787413436148 MirTarget -0.416797676785028 4.54650746681482e-15 NA NA NA hsa-miR-361-5p GNB4 0.971859117235239 5.30236555707088e-09 -0.637235835846949 0.0637787413436148 miRanda;miRNATAP -0.711788578839117 2.31916622157804e-13 NA NA NA hsa-miR-429 GNB4 4.48815175680773 2.44117492218206e-17 -0.637235835846949 0.0637787413436148 miRanda -0.35802227541613 6.09495863227166e-39 NA NA NA hsa-miR-501-5p GNB4 1.93654809410041 1.3779381780759e-10 -0.637235835846949 0.0637787413436148 mirMAP -0.244167840839471 9.96965162188072e-06 NA NA NA hsa-miR-582-5p GNB4 0.609226359812689 0.032988717891497 -0.637235835846949 0.0637787413436148 MirTarget -0.355773912086893 5.28055893795784e-10 NA NA NA hsa-miR-877-5p GNB4 2.94916202082736 1.8151927276044e-13 -0.637235835846949 0.0637787413436148 MirTarget -0.26024285659458 6.14734036375707e-09 NA NA NA hsa-miR-93-5p GNB4 3.03961860136032 1.11672209617395e-24 -0.637235835846949 0.0637787413436148 miRNAWalker2_validate -0.46591844935709 4.02316238221017e-20 NA NA NA hsa-miR-96-5p GNB4 4.89433085814374 1.92000659886961e-31 -0.637235835846949 0.0637787413436148 MirTarget -0.338685707733092 4.78652097617994e-21 NA NA NA hsa-miR-128-3p GNB5 1.63756041666078 6.79626586407187e-14 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.213252596980441 3.20411533204574e-09 NA NA NA hsa-miR-130b-3p GNB5 3.5350292994509 1.73934183852569e-27 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.156991330989953 9.70422622073259e-12 NA NA NA hsa-miR-17-5p GNB5 3.2710598467455 9.93128340539455e-27 -0.839186629235185 5.42372549345636e-07 TargetScan -0.157422525493657 1.81637594978173e-10 NA NA NA hsa-miR-26b-5p GNB5 0.885393662798425 3.2116297961629e-06 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.136961383665604 0.00146595434447694 NA NA NA hsa-miR-338-3p GNB5 0.453166438193782 0.144583389707558 -0.839186629235185 5.42372549345636e-07 miRanda -0.112890802011661 1.71063885448933e-05 NA NA NA hsa-miR-342-3p GNB5 1.49115144672245 1.43879249744621e-07 -0.839186629235185 5.42372549345636e-07 miRanda -0.134199633314021 2.13157413029708e-06 NA NA NA hsa-miR-361-5p GNB5 0.971859117235239 5.30236555707088e-09 -0.839186629235185 5.42372549345636e-07 miRanda -0.243716514423257 5.35175739330283e-07 NA NA NA hsa-miR-425-5p GNB5 3.07071373939774 4.02947460586085e-25 -0.839186629235185 5.42372549345636e-07 miRNAWalker2_validate -0.190730698510053 4.96622354891869e-14 NA NA NA hsa-miR-542-3p GNB5 1.18832665895751 1.98700670691565e-07 -0.839186629235185 5.42372549345636e-07 miRanda -0.170586839558852 1.30397148341979e-06 NA NA NA hsa-miR-590-3p GNB5 2.59289455139753 1.03200520972022e-21 -0.839186629235185 5.42372549345636e-07 miRanda -0.156055107257856 9.65303604312259e-08 NA NA NA hsa-miR-320a GNG11 0.438165828017084 0.0390159073347133 -2.05664853112334 2.60910520564216e-14 miRanda -0.202155625710573 0.00157136796729667 NA NA NA hsa-miR-320b GNG11 1.55692969039548 1.41071034251915e-08 -2.05664853112334 2.60910520564216e-14 miRanda -0.330998429874158 2.5949257931811e-12 NA NA NA hsa-miR-330-5p GNG11 1.15100069700871 4.85551805046014e-07 -2.05664853112334 2.60910520564216e-14 miRanda -0.277412112888266 1.77285723228506e-06 NA NA NA hsa-miR-107 GNG12 1.30977326593435 1.30372468603965e-11 -1.00694431810149 1.61985728260734e-06 miRanda -0.325194911035192 2.35617021655576e-10 NA NA NA hsa-miR-126-5p GNG12 0.895338176458417 2.33372756450713e-05 -1.00694431810149 1.61985728260734e-06 mirMAP -0.216265925507577 7.06592392108692e-06 NA NA NA hsa-miR-140-5p GNG12 0.844753502512594 3.73722278438606e-05 -1.00694431810149 1.61985728260734e-06 PITA;miRanda -0.215923167393918 1.48186394256009e-05 NA NA NA hsa-miR-186-5p GNG12 1.47445398888668 3.0781726595413e-15 -1.00694431810149 1.61985728260734e-06 miRNAWalker2_validate -0.290324396097542 4.28690446751612e-08 NA NA NA hsa-miR-30d-3p GNG12 0.977747550180601 4.3048212205381e-05 -1.00694431810149 1.61985728260734e-06 mirMAP -0.268445146648906 1.78296007701357e-10 NA NA NA hsa-miR-30e-3p GNG12 -0.215663037684509 0.235375122783546 -1.00694431810149 1.61985728260734e-06 mirMAP -0.232213452778567 4.65209274857153e-05 NA NA NA hsa-miR-374a-5p GNG12 0.484615721953736 0.0042981729815149 -1.00694431810149 1.61985728260734e-06 mirMAP -0.213351975656957 0.000483455395337009 NA NA NA hsa-miR-409-5p GNG12 1.56949123847358 5.91654175754272e-07 -1.00694431810149 1.61985728260734e-06 PITA -0.165828998572686 9.83801581754514e-07 NA NA NA hsa-miR-423-5p GNG12 0.963563145758616 9.86109015204915e-07 -1.00694431810149 1.61985728260734e-06 miRNAWalker2_validate -0.340366952806888 2.37757447594555e-11 NA NA NA hsa-miR-429 GNG12 4.48815175680773 2.44117492218206e-17 -1.00694431810149 1.61985728260734e-06 miRanda -0.161475795423235 1.09474596004218e-19 NA NA NA hsa-miR-508-3p GNG12 1.05493034310846 0.0393857095042515 -1.00694431810149 1.61985728260734e-06 mirMAP -0.109947026301814 5.08686689387732e-08 NA NA NA hsa-miR-542-3p GNG12 1.18832665895751 1.98700670691565e-07 -1.00694431810149 1.61985728260734e-06 miRanda -0.168110144177005 0.000154291626655441 NA NA NA hsa-miR-590-3p GNG12 2.59289455139753 1.03200520972022e-21 -1.00694431810149 1.61985728260734e-06 miRanda;mirMAP -0.204473638976492 2.35752221652166e-08 NA NA NA hsa-miR-590-5p GNG12 3.18300989862077 2.06813568597893e-26 -1.00694431810149 1.61985728260734e-06 PITA -0.219549663318668 1.24972971345505e-11 NA NA NA hsa-miR-96-5p GNG12 4.89433085814374 1.92000659886961e-31 -1.00694431810149 1.61985728260734e-06 TargetScan -0.203127178908812 7.44354635001805e-20 NA NA NA hsa-miR-181c-5p GNG2 1.58587920618301 1.57506918816933e-10 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.21465028336591 0.000485266762019858 NA NA NA hsa-miR-23a-3p GNG2 1.00493340843378 2.55313889288924e-08 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.31584441982254 0.000227079160987913 NA NA NA hsa-miR-23b-3p GNG2 -0.251132426825047 0.150200321210792 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.385954021469517 1.79074816028985e-05 NA NA NA hsa-miR-28-5p GNG2 0.230152919654905 0.0742909586754846 -1.3576212262363 2.04502229623169e-05 miRanda;miRNATAP -0.393158661465059 0.00157741925316573 NA NA NA hsa-miR-29b-3p GNG2 1.65828197923813 1.02676780888141e-09 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.214697013701517 0.000129615129388853 NA NA NA hsa-miR-29c-3p GNG2 -0.00968972577705429 0.97099586346872 -1.3576212262363 2.04502229623169e-05 miRNATAP -0.29316634790736 4.49460145833738e-07 NA NA NA hsa-miR-3065-5p GNG2 2.74629919868982 1.86846589298284e-08 -1.3576212262363 2.04502229623169e-05 mirMAP;miRNATAP -0.19253828440026 3.96508273392714e-07 NA NA NA hsa-miR-30d-3p GNG2 0.977747550180601 4.3048212205381e-05 -1.3576212262363 2.04502229623169e-05 mirMAP -0.513300020225803 3.01900186843667e-16 NA NA NA hsa-miR-30e-3p GNG2 -0.215663037684509 0.235375122783546 -1.3576212262363 2.04502229623169e-05 mirMAP -0.405914477167732 2.43350600762805e-06 NA NA NA hsa-miR-324-5p GNG2 2.95683728155095 1.32960514360912e-20 -1.3576212262363 2.04502229623169e-05 miRanda -0.293763157441407 1.41347118146231e-10 NA NA NA hsa-miR-330-5p GNG2 1.15100069700871 4.85551805046014e-07 -1.3576212262363 2.04502229623169e-05 miRanda -0.286226496141626 2.02806491054351e-05 NA NA NA hsa-miR-335-3p GNG2 3.08791651139852 5.31309869723517e-12 -1.3576212262363 2.04502229623169e-05 mirMAP -0.204524138879155 7.32871063541175e-10 NA NA NA hsa-miR-429 GNG2 4.48815175680773 2.44117492218206e-17 -1.3576212262363 2.04502229623169e-05 miRanda;miRNATAP -0.331914241042916 3.62710052422193e-38 NA NA NA hsa-miR-576-5p GNG2 2.20467023993664 3.4053475193793e-19 -1.3576212262363 2.04502229623169e-05 mirMAP -0.257529688449422 1.9736249431505e-05 NA NA NA hsa-miR-590-3p GNG2 2.59289455139753 1.03200520972022e-21 -1.3576212262363 2.04502229623169e-05 PITA;miRanda;mirMAP;miRNATAP -0.166031330399532 0.00314938774617366 NA NA NA hsa-miR-590-5p GNG2 3.18300989862077 2.06813568597893e-26 -1.3576212262363 2.04502229623169e-05 miRanda;miRNATAP -0.251863772930653 4.00935454984172e-07 NA NA NA hsa-miR-944 GNG2 2.91186649218281 1.31574753528144e-06 -1.3576212262363 2.04502229623169e-05 mirMAP -0.233642534231636 1.50210162128137e-20 NA NA NA hsa-miR-141-3p GNG4 5.02396127982626 2.19224509139725e-24 0.216159437363437 0.744682539041036 mirMAP -0.31409320803834 2.17335380219881e-07 NA NA NA hsa-miR-200a-3p GNG4 4.59434485520731 6.38952518573476e-18 0.216159437363437 0.744682539041036 mirMAP -0.332232611120332 4.81558966773253e-09 NA NA NA hsa-miR-200b-3p GNG4 3.78235093249346 3.18343003239465e-14 0.216159437363437 0.744682539041036 mirMAP -0.36236807268835 3.2889821314364e-09 NA NA NA hsa-miR-200c-3p GNG4 3.50132673580082 2.42716349086937e-15 0.216159437363437 0.744682539041036 mirMAP -0.415747931208297 1.50663821120222e-09 NA NA NA hsa-miR-3913-5p GNG4 2.44353493655328 8.95279496632448e-15 0.216159437363437 0.744682539041036 mirMAP -0.440853203267675 1.24030418788711e-05 NA NA NA hsa-miR-429 GNG4 4.48815175680773 2.44117492218206e-17 0.216159437363437 0.744682539041036 mirMAP -0.299425628163015 1.80796068967457e-07 NA NA NA hsa-miR-141-3p GNG7 5.02396127982626 2.19224509139725e-24 -3.47904747202308 1.83990532659951e-21 MirTarget;TargetScan;miRNATAP -0.30384219654589 5.18426669901378e-19 NA NA NA hsa-miR-17-3p GNG7 2.2704817679209 1.1667437320211e-22 -3.47904747202308 1.83990532659951e-21 mirMAP -0.684476176313002 7.68486674689711e-21 NA NA NA hsa-miR-181a-2-3p GNG7 2.19062681262366 3.81790102612782e-13 -3.47904747202308 1.83990532659951e-21 mirMAP -0.335669935644941 1.43374984371638e-08 NA NA NA hsa-miR-182-5p GNG7 3.53923166221814 5.07781258121574e-21 -3.47904747202308 1.83990532659951e-21 mirMAP -0.33394588120831 3.25159373659616e-13 NA NA NA hsa-miR-185-3p GNG7 2.3922478518806 1.3373426768452e-14 -3.47904747202308 1.83990532659951e-21 mirMAP -0.438607972404773 6.85525137484324e-15 NA NA NA hsa-miR-18a-3p GNG7 2.14813400940323 2.23460809936028e-06 -3.47904747202308 1.83990532659951e-21 mirMAP -0.35654455370598 9.55382918035363e-13 NA NA NA hsa-miR-18a-5p GNG7 3.78535678765353 3.72446596213886e-26 -3.47904747202308 1.83990532659951e-21 mirMAP -0.453466540974555 4.53012964759705e-20 NA NA NA hsa-miR-193b-5p GNG7 1.59567208918739 4.89398272459427e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.510359949062033 3.3741341742903e-17 NA NA NA hsa-miR-1976 GNG7 2.06550563678192 7.81396978619772e-18 -3.47904747202308 1.83990532659951e-21 mirMAP -0.525455269718449 5.64587335164917e-13 NA NA NA hsa-miR-200a-3p GNG7 4.59434485520731 6.38952518573476e-18 -3.47904747202308 1.83990532659951e-21 MirTarget;miRNATAP -0.217504146423653 3.11251108490255e-11 NA NA NA hsa-miR-22-3p GNG7 1.21545661147757 1.61670170137775e-13 -3.47904747202308 1.83990532659951e-21 mirMAP -0.388779813370745 0.000472338496755928 NA NA NA hsa-miR-22-5p GNG7 1.88011544159252 1.63978222572222e-16 -3.47904747202308 1.83990532659951e-21 mirMAP -0.376456368932511 1.58429041782012e-06 NA NA NA hsa-miR-224-5p GNG7 2.94107125335675 5.72194099515157e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.213933941333942 9.91359689545342e-11 NA NA NA hsa-miR-23a-3p GNG7 1.00493340843378 2.55313889288924e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.798801855523738 1.00550050246051e-15 NA NA NA hsa-miR-31-3p GNG7 2.70807981248858 8.84479434501203e-05 -3.47904747202308 1.83990532659951e-21 mirMAP -0.177163720921599 8.88786109564702e-10 NA NA NA hsa-miR-31-5p GNG7 3.59165123035072 2.27423212057482e-07 -3.47904747202308 1.83990532659951e-21 mirMAP -0.198201946727868 3.73578574505353e-13 NA NA NA hsa-miR-3127-5p GNG7 1.51846438737133 3.59571251672767e-07 -3.47904747202308 1.83990532659951e-21 mirMAP -0.280682611037895 4.52736303278137e-06 NA NA NA hsa-miR-330-5p GNG7 1.15100069700871 4.85551805046014e-07 -3.47904747202308 1.83990532659951e-21 mirMAP -0.386056825779043 1.45376282981714e-06 NA NA NA hsa-miR-3614-5p GNG7 2.17736331059655 2.19144831318484e-08 -3.47904747202308 1.83990532659951e-21 mirMAP -0.29266188230583 9.94205791272714e-10 NA NA NA hsa-miR-3615 GNG7 2.22631608637736 1.11307777062266e-16 -3.47904747202308 1.83990532659951e-21 mirMAP -0.542864787918364 3.26053388101788e-16 NA NA NA hsa-miR-3913-5p GNG7 2.44353493655328 8.95279496632448e-15 -3.47904747202308 1.83990532659951e-21 mirMAP -0.18866018319481 0.00134615525889515 NA NA NA hsa-miR-500a-3p GNG7 1.47161373123699 5.30571342631915e-09 -3.47904747202308 1.83990532659951e-21 mirMAP -0.26612311178083 0.000247224078153993 NA NA NA hsa-miR-532-3p GNG7 1.96631878320218 4.53421954361695e-13 -3.47904747202308 1.83990532659951e-21 mirMAP -0.432788752985029 3.68415403004414e-11 NA NA NA hsa-miR-590-3p GNG7 2.59289455139753 1.03200520972022e-21 -3.47904747202308 1.83990532659951e-21 PITA;miRanda;mirMAP -0.533820994714737 2.21837557375079e-16 NA NA NA hsa-miR-671-5p GNG7 2.97733652243246 1.21148452344738e-23 -3.47904747202308 1.83990532659951e-21 mirMAP -0.508975052093562 4.0726461912807e-17 NA NA NA hsa-miR-766-3p GNG7 1.2456012547833 6.44584025471128e-06 -3.47904747202308 1.83990532659951e-21 MirTarget -0.28089398115972 2.44037562044379e-05 NA NA NA hsa-miR-92a-3p GNG7 2.06460102658973 1.44784291084757e-19 -3.47904747202308 1.83990532659951e-21 miRNAWalker2_validate -0.716653835819047 8.40156233472874e-22 NA NA NA hsa-miR-940 GNG7 3.21011374578759 2.7923171128495e-14 -3.47904747202308 1.83990532659951e-21 MirTarget -0.340249290712474 6.0759666731278e-14 NA NA NA hsa-miR-96-5p GNG7 4.89433085814374 1.92000659886961e-31 -3.47904747202308 1.83990532659951e-21 mirMAP -0.346426590246556 1.50679346630299e-17 NA NA NA hsa-miR-2110 GNGT2 1.16625590651194 6.4784195289885e-05 -0.202884200576091 0.562224213234923 miRNATAP -0.216445830254323 0.000460270527773238 NA NA NA hsa-miR-219a-1-3p GNGT2 1.14752647140971 0.00048791524196346 -0.202884200576091 0.562224213234923 MirTarget -0.443679432298624 2.24756675612032e-15 NA NA NA hsa-miR-335-5p GNGT2 1.77247705492746 2.22457658872091e-06 -0.202884200576091 0.562224213234923 miRNAWalker2_validate -0.150080296455862 0.000750747471335338 NA NA NA hsa-miR-320a GRB2 0.438165828017084 0.0390159073347133 0.0788721517658564 0.390920910556044 MirTarget;miRanda;mirMAP;miRNATAP -0.105017257701224 3.72382950677321e-07 NA NA NA hsa-let-7a-3p GRIN2A 1.42015538786275 7.03375209382654e-13 -3.3233994538381 1.07825857067501e-08 mirMAP -0.590766951753201 2.90847455315563e-05 NA NA NA hsa-let-7b-3p GRIN2A 0.868207752019623 1.30460056774366e-05 -3.3233994538381 1.07825857067501e-08 mirMAP -0.584478142928055 4.44008963530893e-05 NA NA NA hsa-let-7f-1-3p GRIN2A 1.55054488387679 7.31326775537952e-11 -3.3233994538381 1.07825857067501e-08 mirMAP -0.402647989930892 0.00091336545613493 NA NA NA hsa-miR-107 GRIN2A 1.30977326593435 1.30372468603965e-11 -3.3233994538381 1.07825857067501e-08 miRanda -0.704722380004574 1.07884325402851e-06 NA NA NA hsa-miR-125a-5p GRIN2A 0.599529391575274 0.0102300147180307 -3.3233994538381 1.07825857067501e-08 PITA -0.329789427479611 0.00743001945081907 NA NA NA hsa-miR-126-5p GRIN2A 0.895338176458417 2.33372756450713e-05 -3.3233994538381 1.07825857067501e-08 mirMAP -0.465885972146959 0.0005546904000701 NA NA NA hsa-miR-130b-5p GRIN2A 2.9963110846538 1.98883029416455e-18 -3.3233994538381 1.07825857067501e-08 mirMAP -0.511908496874152 2.46757253096221e-10 NA NA NA hsa-miR-148b-5p GRIN2A 2.18024067300781 2.84770452413262e-14 -3.3233994538381 1.07825857067501e-08 mirMAP -0.627612985039415 4.64332437558424e-10 NA NA NA hsa-miR-15b-3p GRIN2A 2.33847028227712 4.29662877950836e-19 -3.3233994538381 1.07825857067501e-08 mirMAP -0.732656968229508 8.04204313169774e-13 NA NA NA hsa-miR-182-5p GRIN2A 3.53923166221814 5.07781258121574e-21 -3.3233994538381 1.07825857067501e-08 mirMAP -0.433021080719212 1.17139439458597e-09 NA NA NA hsa-miR-186-5p GRIN2A 1.47445398888668 3.0781726595413e-15 -3.3233994538381 1.07825857067501e-08 mirMAP -0.941463081828034 1.43551942888761e-10 NA NA NA hsa-miR-200b-3p GRIN2A 3.78235093249346 3.18343003239465e-14 -3.3233994538381 1.07825857067501e-08 TargetScan -0.326021493354312 2.42792457060316e-09 NA NA NA hsa-miR-224-5p GRIN2A 2.94107125335675 5.72194099515157e-08 -3.3233994538381 1.07825857067501e-08 mirMAP -0.159327637827898 0.00211646296710308 NA NA NA hsa-miR-23a-3p GRIN2A 1.00493340843378 2.55313889288924e-08 -3.3233994538381 1.07825857067501e-08 mirMAP -0.73375486777915 2.91758835951722e-06 NA NA NA hsa-miR-25-3p GRIN2A 1.36472605225697 4.83790725935681e-11 -3.3233994538381 1.07825857067501e-08 mirMAP -0.578845600386365 1.83359090226881e-05 NA NA NA hsa-miR-29a-5p GRIN2A 1.46749674755271 3.34605004270294e-07 -3.3233994538381 1.07825857067501e-08 mirMAP -0.380702018647791 0.000245824043206901 NA NA NA hsa-miR-32-3p GRIN2A 2.02436999565685 5.94091197945307e-09 -3.3233994538381 1.07825857067501e-08 mirMAP -0.351221835777312 0.00013304589811325 NA NA NA hsa-miR-320a GRIN2A 0.438165828017084 0.0390159073347133 -3.3233994538381 1.07825857067501e-08 PITA -0.541191138532479 6.32246039246166e-05 NA NA NA hsa-miR-320b GRIN2A 1.55692969039548 1.41071034251915e-08 -3.3233994538381 1.07825857067501e-08 PITA -0.559241853768533 3.60567826326327e-08 NA NA NA hsa-miR-335-3p GRIN2A 3.08791651139852 5.31309869723517e-12 -3.3233994538381 1.07825857067501e-08 mirMAP -0.203357699157901 0.00105837418473991 NA NA NA hsa-miR-33a-3p GRIN2A 1.72765312072219 1.51784443453521e-07 -3.3233994538381 1.07825857067501e-08 mirMAP -0.483346807992912 2.25698085767383e-07 NA NA NA hsa-miR-34a-3p GRIN2A 1.75590866103657 8.02801510630657e-09 -3.3233994538381 1.07825857067501e-08 mirMAP -0.497080909536274 1.09354087082569e-06 NA NA NA hsa-miR-361-5p GRIN2A 0.971859117235239 5.30236555707088e-09 -3.3233994538381 1.07825857067501e-08 miRanda -0.905043796360747 9.5043936081376e-08 NA NA NA hsa-miR-362-3p GRIN2A 2.0756816987665 3.89026064579331e-12 -3.3233994538381 1.07825857067501e-08 miRanda -0.302615694517096 0.00170803036713368 NA NA NA hsa-miR-582-5p GRIN2A 0.609226359812689 0.032988717891497 -3.3233994538381 1.07825857067501e-08 mirMAP -0.333722034500019 0.000865264636627891 NA NA NA hsa-miR-590-3p GRIN2A 2.59289455139753 1.03200520972022e-21 -3.3233994538381 1.07825857067501e-08 miRanda;mirMAP -0.557190701093152 5.00411547523846e-08 NA NA NA hsa-miR-590-5p GRIN2A 3.18300989862077 2.06813568597893e-26 -3.3233994538381 1.07825857067501e-08 miRanda -0.650391593317497 5.10677315876394e-13 NA NA NA hsa-miR-592 GRIN2A 1.51765968871077 0.000636335248013204 -3.3233994538381 1.07825857067501e-08 PITA -0.31014916245186 1.64113455076279e-06 NA NA NA hsa-miR-629-5p GRIN2A 2.10182419359635 1.51788571125757e-15 -3.3233994538381 1.07825857067501e-08 mirMAP -0.508812873435863 1.06516184837642e-06 NA NA NA hsa-miR-7-1-3p GRIN2A 1.84950311431067 1.25300363397654e-13 -3.3233994538381 1.07825857067501e-08 mirMAP -0.526566366424931 2.03682170878494e-06 NA NA NA hsa-miR-877-5p GRIN2A 2.94916202082736 1.8151927276044e-13 -3.3233994538381 1.07825857067501e-08 mirMAP -0.443001204792636 9.07135781408231e-09 NA NA NA hsa-miR-92a-3p GRIN2A 2.06460102658973 1.44784291084757e-19 -3.3233994538381 1.07825857067501e-08 mirMAP -0.871991707162015 1.06913608490231e-13 NA NA NA hsa-let-7a-3p HGF 1.42015538786275 7.03375209382654e-13 -2.96833708580794 2.21214820634191e-07 mirMAP -0.542810606112975 9.43474905006386e-05 NA NA NA hsa-let-7b-3p HGF 0.868207752019623 1.30460056774366e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.566084083307672 5.71312900566914e-05 NA NA NA hsa-let-7f-1-3p HGF 1.55054488387679 7.31326775537952e-11 -2.96833708580794 2.21214820634191e-07 mirMAP -0.343222022733725 0.00407354838842982 NA NA NA hsa-miR-129-5p HGF -0.524170159980738 0.222582956006346 -2.96833708580794 2.21214820634191e-07 mirMAP -0.176315710478523 0.00827877952568297 NA NA NA hsa-miR-141-3p HGF 5.02396127982626 2.19224509139725e-24 -2.96833708580794 2.21214820634191e-07 MirTarget;TargetScan -0.676636907580645 1.12497659260577e-44 NA NA NA hsa-miR-181a-5p HGF 2.29556023480783 1.8138457900616e-21 -2.96833708580794 2.21214820634191e-07 mirMAP -0.725020652043404 2.96259222943239e-11 NA NA NA hsa-miR-181b-5p HGF 2.49307679431293 3.92829250217627e-20 -2.96833708580794 2.21214820634191e-07 mirMAP -0.706743272553437 2.55576874895847e-13 NA NA NA hsa-miR-181c-5p HGF 1.58587920618301 1.57506918816933e-10 -2.96833708580794 2.21214820634191e-07 mirMAP -0.655855093153665 2.2633028663108e-09 NA NA NA hsa-miR-200a-3p HGF 4.59434485520731 6.38952518573476e-18 -2.96833708580794 2.21214820634191e-07 MirTarget -0.565686401356116 7.92905519776232e-34 NA NA NA hsa-miR-203a-3p HGF 3.12352008343999 9.49391438647189e-07 -2.96833708580794 2.21214820634191e-07 MirTarget -0.307285226038045 3.93961477705831e-13 NA NA NA hsa-miR-224-3p HGF 1.87536386559317 6.15140969394846e-05 -2.96833708580794 2.21214820634191e-07 mirMAP -0.425091238537773 2.95664734683986e-12 NA NA NA hsa-miR-26b-5p HGF 0.885393662798425 3.2116297961629e-06 -2.96833708580794 2.21214820634191e-07 MirTarget;miRNATAP -0.860917332821866 3.45908003051971e-09 NA NA NA hsa-miR-30b-5p HGF 0.800822374912712 0.000133601914525413 -2.96833708580794 2.21214820634191e-07 mirMAP -0.745493458613655 1.87319496040024e-08 NA NA NA hsa-miR-30c-5p HGF 0.778774633108 0.000285599212429136 -2.96833708580794 2.21214820634191e-07 mirMAP -0.865812342797699 1.59173376397441e-11 NA NA NA hsa-miR-30d-5p HGF 0.675423997639582 0.00270618816039773 -2.96833708580794 2.21214820634191e-07 mirMAP -1.14363195060416 9.73383073509946e-22 NA NA NA hsa-miR-30e-5p HGF 1.23904909539663 1.35561917122157e-09 -2.96833708580794 2.21214820634191e-07 mirMAP -1.43246567275328 1.85577963409756e-29 NA NA NA hsa-miR-335-3p HGF 3.08791651139852 5.31309869723517e-12 -2.96833708580794 2.21214820634191e-07 mirMAP -0.296203494255056 9.94228604078741e-07 NA NA NA hsa-miR-33a-3p HGF 1.72765312072219 1.51784443453521e-07 -2.96833708580794 2.21214820634191e-07 mirMAP -0.709152405531059 2.95855303843078e-15 NA NA NA hsa-miR-421 HGF 1.17791565395543 6.78526676976629e-06 -2.96833708580794 2.21214820634191e-07 miRanda -0.423367559608824 7.10463304822239e-05 NA NA NA hsa-miR-429 HGF 4.48815175680773 2.44117492218206e-17 -2.96833708580794 2.21214820634191e-07 miRanda -0.520793016805242 9.95726908305676e-28 NA NA NA hsa-miR-582-5p HGF 0.609226359812689 0.032988717891497 -2.96833708580794 2.21214820634191e-07 PITA -0.41813369111985 1.98992264527824e-05 NA NA NA hsa-miR-590-3p HGF 2.59289455139753 1.03200520972022e-21 -2.96833708580794 2.21214820634191e-07 miRanda;mirMAP -0.643510815709232 1.09614685120259e-10 NA NA NA hsa-miR-590-5p HGF 3.18300989862077 2.06813568597893e-26 -2.96833708580794 2.21214820634191e-07 miRanda -0.712648418249155 4.67151690440208e-16 NA NA NA hsa-miR-651-5p HGF 2.32951837918862 1.62508965949028e-11 -2.96833708580794 2.21214820634191e-07 MirTarget -0.876408480048342 2.87757604471444e-25 NA NA NA hsa-miR-7-1-3p HGF 1.84950311431067 1.25300363397654e-13 -2.96833708580794 2.21214820634191e-07 mirMAP -0.580271470067749 8.96109537411397e-08 NA NA NA hsa-miR-944 HGF 2.91186649218281 1.31574753528144e-06 -2.96833708580794 2.21214820634191e-07 mirMAP -0.408051827291836 3.7779107870685e-19 NA NA NA hsa-miR-143-3p HRAS -2.5789192793377 1.55518999614836e-14 0.623195449314017 0.00175543589552248 miRNAWalker2_validate;miRTarBase -0.162589208332201 3.09270971499286e-09 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-324-5p HTR7 2.95683728155095 1.32960514360912e-20 -0.852837432457614 0.175178303419063 miRanda -0.298248969652344 0.00107530513245708 NA NA NA hsa-miR-326 HTR7 0.715313016136042 0.0610265683213359 -0.852837432457614 0.175178303419063 miRanda;miRNATAP -0.441788648154235 2.17207589526844e-08 NA NA NA hsa-miR-335-5p HTR7 1.77247705492746 2.22457658872091e-06 -0.852837432457614 0.175178303419063 miRNAWalker2_validate -0.310968996628653 0.000100400501657607 NA NA NA hsa-miR-375 HTR7 1.13910305294079 0.0512283522214186 -0.852837432457614 0.175178303419063 miRanda -0.341563779348512 1.74284174308163e-11 NA NA NA hsa-miR-491-5p HTR7 0.615770352820862 0.0418295628761654 -0.852837432457614 0.175178303419063 miRanda -0.378205935990802 0.00044690726803032 NA NA NA hsa-let-7a-3p IGF1 1.42015538786275 7.03375209382654e-13 -3.75951127345565 1.26264890381366e-10 mirMAP -0.92426917804667 5.0725450948492e-11 NA NA NA hsa-let-7a-5p IGF1 0.618599506841644 2.76973453058748e-05 -3.75951127345565 1.26264890381366e-10 TargetScan -1.35484578107079 3.03432417502265e-12 NA NA NA hsa-let-7b-3p IGF1 0.868207752019623 1.30460056774366e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.806527950481254 1.86996353532323e-08 NA NA NA hsa-let-7f-1-3p IGF1 1.55054488387679 7.31326775537952e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.53583367534408 1.14955943868674e-05 NA NA NA hsa-miR-103a-2-5p IGF1 2.47599305985086 7.933028987326e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.672288935268143 1.21134250789966e-16 NA NA NA hsa-miR-129-5p IGF1 -0.524170159980738 0.222582956006346 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRanda -0.24872412851026 0.000279350666200339 NA NA NA hsa-miR-130a-3p IGF1 2.02021855058359 1.26427102520415e-11 -3.75951127345565 1.26264890381366e-10 MirTarget -0.315325422858442 0.000861190344159203 NA NA NA hsa-miR-130b-3p IGF1 3.5350292994509 1.73934183852569e-27 -3.75951127345565 1.26264890381366e-10 MirTarget -0.781941096991651 4.63853079450254e-23 NA NA NA hsa-miR-15b-3p IGF1 2.33847028227712 4.29662877950836e-19 -3.75951127345565 1.26264890381366e-10 mirMAP -1.14217010288885 5.28861971423639e-31 NA NA NA hsa-miR-16-1-3p IGF1 2.56983217111073 3.02262181237943e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.921958602704484 2.5787665170735e-21 NA NA NA hsa-miR-181a-5p IGF1 2.29556023480783 1.8138457900616e-21 -3.75951127345565 1.26264890381366e-10 mirMAP -0.642043297035051 1.32592036628183e-08 NA NA NA hsa-miR-181b-5p IGF1 2.49307679431293 3.92829250217627e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.697159274066391 2.64064192584975e-12 NA NA NA hsa-miR-181c-5p IGF1 1.58587920618301 1.57506918816933e-10 -3.75951127345565 1.26264890381366e-10 mirMAP -0.418006737238249 0.00025755851863695 NA NA NA hsa-miR-186-5p IGF1 1.47445398888668 3.0781726595413e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -1.20504446214237 1.61828209547411e-16 NA NA NA hsa-miR-19a-3p IGF1 3.42309334186656 3.02671914353412e-28 -3.75951127345565 1.26264890381366e-10 MirTarget -0.788529625251502 2.31580352219079e-21 NA NA NA hsa-miR-19b-1-5p IGF1 2.57951428759379 4.31576118703427e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.995592930242643 1.89907484758614e-25 NA NA NA hsa-miR-19b-3p IGF1 2.49529833021187 1.57028265846699e-23 -3.75951127345565 1.26264890381366e-10 MirTarget -1.0369004238185 3.24569264936101e-23 NA NA NA hsa-miR-20a-3p IGF1 2.92621109947706 2.49504904635375e-17 -3.75951127345565 1.26264890381366e-10 mirMAP -0.809636638775284 3.3899709447565e-25 NA NA NA hsa-miR-224-3p IGF1 1.87536386559317 6.15140969394846e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.362328718988192 1.01049263740062e-08 NA NA NA hsa-miR-26b-5p IGF1 0.885393662798425 3.2116297961629e-06 -3.75951127345565 1.26264890381366e-10 mirMAP -0.940665920848216 3.14292070875382e-10 NA NA NA hsa-miR-27a-3p IGF1 1.66542180327138 4.93775737894805e-13 -3.75951127345565 1.26264890381366e-10 miRNAWalker2_validate;miRTarBase -0.651692554274928 7.73576562076687e-08 NA NA NA hsa-miR-29b-3p IGF1 1.65828197923813 1.02676780888141e-09 -3.75951127345565 1.26264890381366e-10 MirTarget -0.519110555190393 5.59140789276621e-07 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.81024345929638 2.29784847962242e-17 -3.75951127345565 1.26264890381366e-10 MirTarget -0.801898835472881 2.70419582744703e-21 NA NA NA hsa-miR-3065-5p IGF1 2.74629919868982 1.86846589298284e-08 -3.75951127345565 1.26264890381366e-10 mirMAP -0.340906479396581 1.44245852597366e-06 NA NA NA hsa-miR-32-3p IGF1 2.02436999565685 5.94091197945307e-09 -3.75951127345565 1.26264890381366e-10 mirMAP -0.670318737511073 1.52748719371215e-13 NA NA NA hsa-miR-320a IGF1 0.438165828017084 0.0390159073347133 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.87110280497324 9.95766777508728e-11 NA NA NA hsa-miR-320b IGF1 1.55692969039548 1.41071034251915e-08 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.993279990978514 6.22780218264885e-24 NA NA NA hsa-miR-33a-3p IGF1 1.72765312072219 1.51784443453521e-07 -3.75951127345565 1.26264890381366e-10 MirTarget -0.862622681654972 2.52525229105421e-21 NA NA NA hsa-miR-3607-3p IGF1 2.68532138541128 5.66716351955047e-14 -3.75951127345565 1.26264890381366e-10 mirMAP -0.646493669321152 1.00233762873621e-16 NA NA NA hsa-miR-361-5p IGF1 0.971859117235239 5.30236555707088e-09 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP -1.48168691679158 5.53863901928066e-19 NA NA NA hsa-miR-374b-3p IGF1 0.930487774873495 2.74420094310516e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.498455115159369 0.000129551554566347 NA NA NA hsa-miR-3913-5p IGF1 2.44353493655328 8.95279496632448e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.584661382885468 7.3573353974355e-11 NA NA NA hsa-miR-421 IGF1 1.17791565395543 6.78526676976629e-06 -3.75951127345565 1.26264890381366e-10 PITA -0.696572691037999 1.11839961387445e-10 NA NA NA hsa-miR-452-5p IGF1 1.37180058737183 0.00171494843537772 -3.75951127345565 1.26264890381366e-10 MirTarget;mirMAP -0.239891308263067 0.000253591244736158 NA NA NA hsa-miR-454-3p IGF1 2.47234127820054 1.12878018736016e-21 -3.75951127345565 1.26264890381366e-10 MirTarget -0.897384141255581 2.08224455125487e-17 NA NA NA hsa-miR-486-5p IGF1 -0.194913133034028 0.607377798807705 -3.75951127345565 1.26264890381366e-10 PITA;miRNATAP -0.336416232300254 9.17459110593128e-06 NA NA NA hsa-miR-576-5p IGF1 2.20467023993664 3.4053475193793e-19 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP;miRNATAP -1.00551072603292 1.14064166854676e-20 NA NA NA hsa-miR-590-3p IGF1 2.59289455139753 1.03200520972022e-21 -3.75951127345565 1.26264890381366e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.845684857318828 5.27514597787573e-17 NA NA NA hsa-miR-592 IGF1 1.51765968871077 0.000636335248013204 -3.75951127345565 1.26264890381366e-10 mirMAP -0.450455314337535 2.70073065710591e-12 NA NA NA hsa-miR-629-5p IGF1 2.10182419359635 1.51788571125757e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.693559501922869 2.74994850835533e-11 NA NA NA hsa-miR-664a-3p IGF1 0.634721925861133 0.00520070178640421 -3.75951127345565 1.26264890381366e-10 mirMAP -0.350873716989665 0.00610206128936229 NA NA NA hsa-miR-940 IGF1 3.21011374578759 2.7923171128495e-14 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRNATAP -0.715084793572266 1.27978685880086e-25 NA NA NA hsa-let-7d-5p IGF1R 1.33236798905207 1.1741085658466e-13 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;MirTarget;miRNATAP -0.233908899420042 0.000276801000319017 25287248 Focusing on the let-7d-5p/3p pair the respectively targeted IGF1R and KRAS were shown to be in a reverse relationship with expression of the respective miRNA which was confirmed in transient transfection assays using let-7d mimic or inhibitor; Targeting of KRAS by let-7d was previous reported; targeting of IGF1R by let-7d-5p was confirmed in luciferase assays in this study colon cancer hsa-let-7g-5p IGF1R 1.20061455355116 1.50237505511483e-12 -0.486024248749606 0.0460954581792042 MirTarget;miRNATAP -0.302735983859819 8.9121124787433e-06 NA NA NA hsa-let-7i-5p IGF1R 0.412877696970403 0.00622731051981756 -0.486024248749606 0.0460954581792042 MirTarget;miRNATAP -0.228891222780098 0.00403501843356413 NA NA NA hsa-miR-1226-3p IGF1R 1.38118928579963 0.000205503474787488 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.10824109893534 0.00264508157056216 NA NA NA hsa-miR-1306-3p IGF1R 1.7835592527682 5.37873730566685e-08 -0.486024248749606 0.0460954581792042 mirMAP -0.140508877717541 0.000219830668957512 NA NA NA hsa-miR-140-3p IGF1R 0.0608890720479334 0.727716871248724 -0.486024248749606 0.0460954581792042 mirMAP -0.27831144732677 4.48014718263299e-05 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-140-5p IGF1R 0.844753502512594 3.73722278438606e-05 -0.486024248749606 0.0460954581792042 PITA;miRNATAP -0.210132849945263 0.000252820917193275 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-148a-5p IGF1R 1.16173838132242 0.000148929299881612 -0.486024248749606 0.0460954581792042 mirMAP -0.153273555432878 5.76643013870475e-05 NA NA NA hsa-miR-155-5p IGF1R 1.20164021433135 0.00086170622431261 -0.486024248749606 0.0460954581792042 mirMAP -0.109822477719586 0.000717019910707966 NA NA NA hsa-miR-15a-5p IGF1R 2.34669284378787 1.69544424500258e-23 -0.486024248749606 0.0460954581792042 miRNATAP -0.166867754420311 0.000454880786472648 NA NA NA hsa-miR-15b-3p IGF1R 2.33847028227712 4.29662877950836e-19 -0.486024248749606 0.0460954581792042 mirMAP -0.138682202682081 0.00131010066932468 NA NA NA hsa-miR-15b-5p IGF1R 1.57112623124278 9.14247846750597e-13 -0.486024248749606 0.0460954581792042 miRNATAP -0.248371255379639 1.81573519572013e-06 NA NA NA hsa-miR-16-5p IGF1R 1.75824877145857 1.68592440033108e-16 -0.486024248749606 0.0460954581792042 miRNATAP -0.185976273412055 0.000509431308521588 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-185-5p IGF1R 2.34016206907488 1.17481626642022e-26 -0.486024248749606 0.0460954581792042 MirTarget -0.210347183440742 3.18341012357928e-05 NA NA NA hsa-miR-186-5p IGF1R 1.47445398888668 3.0781726595413e-15 -0.486024248749606 0.0460954581792042 mirMAP -0.259580928228016 2.27679515390945e-05 NA NA NA hsa-miR-192-5p IGF1R 2.69002528723195 1.22990188194432e-16 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.162071899497905 2.95566440166205e-06 NA NA NA hsa-miR-193a-5p IGF1R 0.562511612963676 0.0239254699649222 -0.486024248749606 0.0460954581792042 mirMAP -0.135722188768563 0.00426871718315317 NA NA NA hsa-miR-194-5p IGF1R 1.8992998339217 3.76507853301977e-10 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.188748374877298 5.71579919612031e-07 NA NA NA hsa-miR-195-5p IGF1R -1.44753678070504 8.70594292149271e-09 -0.486024248749606 0.0460954581792042 miRNATAP -0.138117817160811 0.00280989255838415 NA NA NA hsa-miR-197-3p IGF1R 1.75733174019505 8.88576793100499e-13 -0.486024248749606 0.0460954581792042 mirMAP -0.184182858103751 7.83269013421259e-05 NA NA NA hsa-miR-19a-3p IGF1R 3.42309334186656 3.02671914353412e-28 -0.486024248749606 0.0460954581792042 mirMAP -0.10754867299782 0.00243372140663191 NA NA NA hsa-miR-215-5p IGF1R 2.30755467422978 2.38476032118039e-06 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.142175668265091 3.8628174812409e-09 NA NA NA hsa-miR-29b-2-5p IGF1R 0.910668640983475 0.00666655585493488 -0.486024248749606 0.0460954581792042 mirMAP -0.119177500662335 0.000665741966203079 NA NA NA hsa-miR-29c-3p IGF1R -0.00968972577705429 0.97099586346872 -0.486024248749606 0.0460954581792042 mirMAP -0.157172588392593 0.000394988588911287 NA NA NA hsa-miR-30c-5p IGF1R 0.778774633108 0.000285599212429136 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.215080796493845 8.67590028266986e-05 NA NA NA hsa-miR-30e-5p IGF1R 1.23904909539663 1.35561917122157e-09 -0.486024248749606 0.0460954581792042 mirMAP -0.224447576166182 7.77702491429068e-05 NA NA NA hsa-miR-339-5p IGF1R 2.68710938429893 3.03134080808154e-16 -0.486024248749606 0.0460954581792042 miRanda -0.120536510471461 0.000473712630520207 NA NA NA hsa-miR-342-3p IGF1R 1.49115144672245 1.43879249744621e-07 -0.486024248749606 0.0460954581792042 mirMAP -0.127400630242107 0.00191533765474422 NA NA NA hsa-miR-342-5p IGF1R 1.74634624752902 3.89286511372155e-11 -0.486024248749606 0.0460954581792042 mirMAP -0.17222881544086 7.73422132892045e-05 NA NA NA hsa-miR-3613-5p IGF1R 2.64358387329263 1.0373753017245e-24 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.125077117428257 0.0049529824143567 NA NA NA hsa-miR-362-3p IGF1R 2.0756816987665 3.89026064579331e-12 -0.486024248749606 0.0460954581792042 PITA -0.206769365293673 1.43775490045472e-07 NA NA NA hsa-miR-3677-3p IGF1R 1.55935355925312 4.80239289905323e-06 -0.486024248749606 0.0460954581792042 MirTarget -0.175911681444773 2.01649902650337e-07 NA NA NA hsa-miR-374a-5p IGF1R 0.484615721953736 0.0042981729815149 -0.486024248749606 0.0460954581792042 mirMAP -0.234001149935664 0.000864680357370787 NA NA NA hsa-miR-374b-5p IGF1R 0.0654362503857184 0.722673188879465 -0.486024248749606 0.0460954581792042 mirMAP -0.260316989857322 5.53324694472522e-05 NA NA NA hsa-miR-378a-5p IGF1R 0.223456081148306 0.386368843153575 -0.486024248749606 0.0460954581792042 mirMAP -0.127780003468782 0.0054319364150493 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-3913-5p IGF1R 2.44353493655328 8.95279496632448e-15 -0.486024248749606 0.0460954581792042 mirMAP -0.126397785568049 0.000687296309514575 NA NA NA hsa-miR-409-5p IGF1R 1.56949123847358 5.91654175754272e-07 -0.486024248749606 0.0460954581792042 PITA -0.104622478580007 0.00774804832597773 NA NA NA hsa-miR-421 IGF1R 1.17791565395543 6.78526676976629e-06 -0.486024248749606 0.0460954581792042 miRanda -0.179133195485579 6.03309149743434e-05 NA NA NA hsa-miR-484 IGF1R 1.81844463411787 1.82951571230938e-15 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.282538218482723 1.04528421031889e-08 NA NA NA hsa-miR-495-3p IGF1R -0.0847115949846082 0.763475496144456 -0.486024248749606 0.0460954581792042 mirMAP -0.119947784452941 0.00444753291132263 NA NA NA hsa-miR-497-5p IGF1R 0.0257087130056286 0.918145413833358 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.152362590794185 0.00129782502934878 NA NA NA hsa-miR-500a-3p IGF1R 1.47161373123699 5.30571342631915e-09 -0.486024248749606 0.0460954581792042 mirMAP -0.308758568854319 7.46172041584498e-12 NA NA NA hsa-miR-532-5p IGF1R 1.55697650978597 1.57884735535196e-11 -0.486024248749606 0.0460954581792042 miRNATAP -0.305954968906114 5.01442184672658e-10 NA NA NA hsa-miR-542-3p IGF1R 1.18832665895751 1.98700670691565e-07 -0.486024248749606 0.0460954581792042 mirMAP -0.150251984416169 0.00332990570749663 NA NA NA hsa-miR-592 IGF1R 1.51765968871077 0.000636335248013204 -0.486024248749606 0.0460954581792042 PITA;miRNATAP -0.124822698210919 2.83708994200769e-06 NA NA NA hsa-miR-625-5p IGF1R 1.42540152147292 1.95797147911206e-06 -0.486024248749606 0.0460954581792042 MirTarget -0.148113785343487 0.000526615821219427 NA NA NA hsa-miR-671-5p IGF1R 2.97733652243246 1.21148452344738e-23 -0.486024248749606 0.0460954581792042 mirMAP -0.129839479602332 0.00106882467611499 NA NA NA hsa-miR-7-1-3p IGF1R 1.84950311431067 1.25300363397654e-13 -0.486024248749606 0.0460954581792042 mirMAP -0.170630021804943 0.00020010536359991 NA NA NA hsa-miR-877-5p IGF1R 2.94916202082736 1.8151927276044e-13 -0.486024248749606 0.0460954581792042 MirTarget -0.105351058260924 0.00105209735401847 NA NA NA hsa-miR-940 IGF1R 3.21011374578759 2.7923171128495e-14 -0.486024248749606 0.0460954581792042 mirMAP -0.112078867143816 0.000138658602668637 NA NA NA hsa-miR-98-5p IGF1R 1.11154309866014 1.24143909012085e-08 -0.486024248749606 0.0460954581792042 MirTarget -0.310419335327057 1.6607359063192e-07 NA NA NA hsa-miR-99b-5p IGF1R 0.814286288944185 0.000299800699512742 -0.486024248749606 0.0460954581792042 miRNATAP -0.14193096371114 0.00677531758993343 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-148a-3p IGF2 1.26728238710376 2.52325607402829e-06 0.0970288554818755 0.912383978798457 mirMAP -0.414453970496451 0.00835190565522827 NA NA NA hsa-miR-193a-3p IGF2 1.60460546928078 2.86169793322984e-07 0.0970288554818755 0.912383978798457 mirMAP -0.553479045878348 3.58467640429877e-05 NA NA NA hsa-miR-193a-5p IGF2 0.562511612963676 0.0239254699649222 0.0970288554818755 0.912383978798457 TargetScan -0.570992734200133 0.000865140051931084 NA NA NA hsa-miR-19a-3p IGF2 3.42309334186656 3.02671914353412e-28 0.0970288554818755 0.912383978798457 mirMAP -0.392861132545829 0.00218920494137348 NA NA NA hsa-miR-19b-3p IGF2 2.49529833021187 1.57028265846699e-23 0.0970288554818755 0.912383978798457 mirMAP -0.461868946453214 0.0043944070924483 NA NA NA hsa-miR-2355-5p IGF2 1.32510310704724 8.25139516692683e-07 0.0970288554818755 0.912383978798457 MirTarget -0.934940253226415 1.4332722095728e-09 NA NA NA hsa-miR-339-5p IGF2 2.68710938429893 3.03134080808154e-16 0.0970288554818755 0.912383978798457 mirMAP -0.35358009661054 0.00467145025038026 NA NA NA hsa-miR-34c-5p IGF2 2.07190852984647 7.35776320806257e-08 0.0970288554818755 0.912383978798457 mirMAP -0.395621340114303 0.000655839251233444 NA NA NA hsa-miR-362-3p IGF2 2.0756816987665 3.89026064579331e-12 0.0970288554818755 0.912383978798457 miRanda -0.408260903092568 0.00451278900607031 NA NA NA hsa-miR-628-5p IGF2 0.799263053510813 2.28892357418044e-05 0.0970288554818755 0.912383978798457 mirMAP -0.638729704782253 0.00486077064668685 NA NA NA hsa-miR-9-5p IGF2 1.02304182473283 0.042901377604859 0.0970288554818755 0.912383978798457 mirMAP -0.229589246411698 0.00634499270083063 NA NA NA hsa-miR-146b-5p IKBKB 1.75587235896724 1.15724631266659e-07 -0.00227190214342876 0.988714147115007 miRanda -0.12253940493918 7.13410135054121e-08 NA NA NA hsa-let-7a-3p INSR 1.42015538786275 7.03375209382654e-13 -0.335737111104281 0.0754278446119288 mirMAP -0.15816973369539 0.000461473183490821 NA NA NA hsa-let-7b-3p INSR 0.868207752019623 1.30460056774366e-05 -0.335737111104281 0.0754278446119288 mirMAP -0.18259237309381 6.27697448618197e-05 NA NA NA hsa-let-7f-1-3p INSR 1.55054488387679 7.31326775537952e-11 -0.335737111104281 0.0754278446119288 mirMAP -0.234879100967927 6.9044840520178e-10 NA NA NA hsa-let-7i-5p INSR 0.412877696970403 0.00622731051981756 -0.335737111104281 0.0754278446119288 miRNATAP -0.341000101339301 1.99898841669127e-08 NA NA NA hsa-miR-127-5p INSR 1.19850695520181 4.10976607177645e-05 -0.335737111104281 0.0754278446119288 PITA -0.114659842304268 0.000209322472841496 NA NA NA hsa-miR-142-5p INSR 1.17581605694506 0.0018174701991234 -0.335737111104281 0.0754278446119288 mirMAP -0.184533831964077 2.57101036960177e-15 NA NA NA hsa-miR-21-5p INSR 2.73773305747971 1.38864982139576e-43 -0.335737111104281 0.0754278446119288 mirMAP -0.288296420322576 1.5840822983789e-12 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-27a-3p INSR 1.66542180327138 4.93775737894805e-13 -0.335737111104281 0.0754278446119288 miRNATAP -0.257598888912134 9.95729032473756e-12 NA NA NA hsa-miR-342-3p INSR 1.49115144672245 1.43879249744621e-07 -0.335737111104281 0.0754278446119288 miRanda -0.173236629545461 3.38807506976711e-08 NA NA NA hsa-miR-424-5p INSR 1.61930224569578 1.89642549274994e-10 -0.335737111104281 0.0754278446119288 miRNATAP -0.111271098127559 0.0015781856467318 NA NA NA hsa-miR-590-3p INSR 2.59289455139753 1.03200520972022e-21 -0.335737111104281 0.0754278446119288 PITA;miRanda;mirMAP;miRNATAP -0.109443531364485 0.000887859920453394 NA NA NA hsa-miR-15b-5p KDR 1.57112623124278 9.14247846750597e-13 -0.809645188569233 0.00140156336172476 miRNATAP -0.155621687078152 0.0045182683141369 NA NA NA hsa-miR-16-5p KDR 1.75824877145857 1.68592440033108e-16 -0.809645188569233 0.00140156336172476 miRTarBase;miRNATAP -0.182939670656605 0.00106812366151133 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 2.57951428759379 4.31576118703427e-20 -0.809645188569233 0.00140156336172476 miRNAWalker2_validate -0.229520229616341 6.75997699685035e-08 NA NA NA hsa-miR-200c-3p KDR 3.50132673580082 2.42716349086937e-15 -0.809645188569233 0.00140156336172476 miRNATAP -0.100553706909197 0.000169957263481419 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-23a-3p KDR 1.00493340843378 2.55313889288924e-08 -0.809645188569233 0.00140156336172476 mirMAP -0.286683208573693 2.23043040222106e-05 NA NA NA hsa-miR-3065-3p KDR 2.16221780121195 9.65525739884541e-09 -0.809645188569233 0.00140156336172476 miRNATAP -0.115781865974172 0.00029357167187714 NA NA NA hsa-miR-455-5p KDR 2.2582442061694 1.43472128037398e-13 -0.809645188569233 0.00140156336172476 PITA;miRanda;miRNATAP -0.148297955432885 0.000143983958437006 NA NA NA hsa-miR-590-3p KDR 2.59289455139753 1.03200520972022e-21 -0.809645188569233 0.00140156336172476 miRanda -0.18919157083552 1.89718911518431e-05 NA NA NA hsa-miR-590-5p KDR 3.18300989862077 2.06813568597893e-26 -0.809645188569233 0.00140156336172476 miRanda -0.161280644562926 4.49661990812652e-05 NA NA NA hsa-let-7f-1-3p KIT 1.55054488387679 7.31326775537952e-11 -2.52159771280238 8.03290749995369e-07 mirMAP -0.668445729598711 1.51130372139265e-10 NA NA NA hsa-miR-125a-3p KIT 1.24490295132072 5.26925231010328e-06 -2.52159771280238 8.03290749995369e-07 miRanda -0.255118298636462 0.00509486668847337 NA NA NA hsa-miR-130a-3p KIT 2.02021855058359 1.26427102520415e-11 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.466185309570644 8.0802122737332e-09 NA NA NA hsa-miR-130b-3p KIT 3.5350292994509 1.73934183852569e-27 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.363470477280817 3.49115745986817e-07 NA NA NA hsa-miR-142-5p KIT 1.17581605694506 0.0018174701991234 -2.52159771280238 8.03290749995369e-07 PITA;miRNATAP -0.366729686646503 1.87812939014732e-08 NA NA NA hsa-miR-146b-5p KIT 1.75587235896724 1.15724631266659e-07 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate -0.416813589432571 1.42119994915586e-08 NA NA NA hsa-miR-186-5p KIT 1.47445398888668 3.0781726595413e-15 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate -0.659172130461391 3.65526184071893e-07 NA NA NA hsa-miR-193a-3p KIT 1.60460546928078 2.86169793322984e-07 -2.52159771280238 8.03290749995369e-07 MirTarget;PITA;miRanda;miRNATAP -0.488922632123506 3.08444759163985e-10 NA NA NA hsa-miR-193b-3p KIT 2.25711804611899 4.1940744806631e-14 -2.52159771280238 8.03290749995369e-07 MirTarget;miRNATAP -0.689620638977969 1.08764423044794e-18 NA NA NA hsa-miR-19a-3p KIT 3.42309334186656 3.02671914353412e-28 -2.52159771280238 8.03290749995369e-07 miRTarBase;miRNATAP -0.492359170089366 2.58837661846889e-11 NA NA NA hsa-miR-19b-3p KIT 2.49529833021187 1.57028265846699e-23 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.605758711501565 8.90523497903026e-11 NA NA NA hsa-miR-205-5p KIT 4.1389800495524 2.05488295686453e-12 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.156777960092351 0.000138207674163266 NA NA NA hsa-miR-20a-5p KIT 3.15577933619191 4.19753346442454e-25 -2.52159771280238 8.03290749995369e-07 miRTarBase -0.457576168379078 1.92521778037074e-09 NA NA NA hsa-miR-221-3p KIT 0.451556679024397 0.0909808299917811 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.405149427467833 1.47261328620332e-05 NA NA NA hsa-miR-222-3p KIT 0.851783756239071 0.00266783568486918 -2.52159771280238 8.03290749995369e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.471589014167227 6.25441385275748e-08 NA NA NA hsa-miR-301a-3p KIT 2.81024345929638 2.29784847962242e-17 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.359299688669289 2.40561125535435e-06 NA NA NA hsa-miR-3065-5p KIT 2.74629919868982 1.86846589298284e-08 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.239450501478508 9.93041712635943e-05 NA NA NA hsa-miR-338-3p KIT 0.453166438193782 0.144583389707558 -2.52159771280238 8.03290749995369e-07 miRanda -0.213122500667458 0.0083854475397935 NA NA NA hsa-miR-342-3p KIT 1.49115144672245 1.43879249744621e-07 -2.52159771280238 8.03290749995369e-07 miRanda -0.498555598512948 6.78222503737131e-09 NA NA NA hsa-miR-34a-5p KIT 1.9016323452565 1.43092834643601e-14 -2.52159771280238 8.03290749995369e-07 MirTarget -0.312332886384761 0.00150658023755356 NA NA NA hsa-miR-450b-5p KIT 1.69244418548325 1.68064054148881e-10 -2.52159771280238 8.03290749995369e-07 MirTarget -0.255623321466667 0.00589465358679959 NA NA NA hsa-miR-454-3p KIT 2.47234127820054 1.12878018736016e-21 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.486460410383953 2.23308592991569e-07 NA NA NA hsa-miR-501-5p KIT 1.93654809410041 1.3779381780759e-10 -2.52159771280238 8.03290749995369e-07 miRNATAP -0.330857176667494 7.26551506682279e-05 NA NA NA hsa-miR-505-3p KIT 1.45322244209148 8.86597629645867e-10 -2.52159771280238 8.03290749995369e-07 MirTarget;miRNATAP -0.371944509463907 0.000339794987685505 NA NA NA hsa-miR-590-3p KIT 2.59289455139753 1.03200520972022e-21 -2.52159771280238 8.03290749995369e-07 miRanda;mirMAP -0.519087288164396 5.92119981865176e-09 NA NA NA hsa-miR-671-5p KIT 2.97733652243246 1.21148452344738e-23 -2.52159771280238 8.03290749995369e-07 MirTarget -0.454665071801787 4.95785958848314e-08 NA NA NA hsa-miR-126-5p KITLG 0.895338176458417 2.33372756450713e-05 -1.58421888595384 1.26958469493711e-05 mirMAP -0.272908961885384 0.00109791686862477 NA NA NA hsa-miR-17-3p KITLG 2.2704817679209 1.1667437320211e-22 -1.58421888595384 1.26958469493711e-05 MirTarget -0.393101365022262 4.72483145331596e-08 NA NA NA hsa-miR-181a-5p KITLG 2.29556023480783 1.8138457900616e-21 -1.58421888595384 1.26958469493711e-05 MirTarget -0.335550426249135 1.41658817648335e-06 NA NA NA hsa-miR-181b-5p KITLG 2.49307679431293 3.92829250217627e-20 -1.58421888595384 1.26958469493711e-05 MirTarget -0.256299176970811 3.77948441551811e-05 NA NA NA hsa-miR-181c-5p KITLG 1.58587920618301 1.57506918816933e-10 -1.58421888595384 1.26958469493711e-05 MirTarget -0.375267300888401 6.43592855187612e-08 NA NA NA hsa-miR-181d-5p KITLG 1.52204912185579 9.2693319057748e-08 -1.58421888595384 1.26958469493711e-05 MirTarget -0.278757212609034 4.95980714874251e-06 NA NA NA hsa-miR-185-5p KITLG 2.34016206907488 1.17481626642022e-26 -1.58421888595384 1.26958469493711e-05 miRNAWalker2_validate -0.497221789302377 3.08433724856098e-11 NA NA NA hsa-miR-186-5p KITLG 1.47445398888668 3.0781726595413e-15 -1.58421888595384 1.26958469493711e-05 mirMAP -0.634325234856109 2.3833607940713e-12 NA NA NA hsa-miR-188-5p KITLG 2.52825126596644 6.78099435999778e-14 -1.58421888595384 1.26958469493711e-05 MirTarget -0.158300742158382 0.00356546035156523 NA NA NA hsa-miR-19a-3p KITLG 3.42309334186656 3.02671914353412e-28 -1.58421888595384 1.26958469493711e-05 mirMAP -0.295616865695893 1.97462506125613e-08 NA NA NA hsa-miR-19b-3p KITLG 2.49529833021187 1.57028265846699e-23 -1.58421888595384 1.26958469493711e-05 mirMAP -0.413630495127345 4.24005211940184e-10 NA NA NA hsa-miR-205-5p KITLG 4.1389800495524 2.05488295686453e-12 -1.58421888595384 1.26958469493711e-05 mirMAP -0.117072550460012 5.69160994612424e-05 NA NA NA hsa-miR-26b-5p KITLG 0.885393662798425 3.2116297961629e-06 -1.58421888595384 1.26958469493711e-05 mirMAP -0.563591788866142 7.88944359372229e-10 NA NA NA hsa-miR-30b-5p KITLG 0.800822374912712 0.000133601914525413 -1.58421888595384 1.26958469493711e-05 mirMAP -0.373437144222724 9.06999703155285e-06 NA NA NA hsa-miR-30c-5p KITLG 0.778774633108 0.000285599212429136 -1.58421888595384 1.26958469493711e-05 mirMAP -0.489316558126056 1.8498271253835e-09 NA NA NA hsa-miR-30d-3p KITLG 0.977747550180601 4.3048212205381e-05 -1.58421888595384 1.26958469493711e-05 MirTarget -0.445191677600574 9.67622181853915e-10 NA NA NA hsa-miR-30d-5p KITLG 0.675423997639582 0.00270618816039773 -1.58421888595384 1.26958469493711e-05 mirMAP -0.466126096391756 1.99145566818422e-09 NA NA NA hsa-miR-30e-3p KITLG -0.215663037684509 0.235375122783546 -1.58421888595384 1.26958469493711e-05 MirTarget -0.382077752173622 0.000105770526649688 NA NA NA hsa-miR-30e-5p KITLG 1.23904909539663 1.35561917122157e-09 -1.58421888595384 1.26958469493711e-05 mirMAP -0.732751398239663 5.51580529001383e-19 NA NA NA hsa-miR-32-3p KITLG 2.02436999565685 5.94091197945307e-09 -1.58421888595384 1.26958469493711e-05 mirMAP -0.268247170000525 2.19511785328886e-06 NA NA NA hsa-miR-320a KITLG 0.438165828017084 0.0390159073347133 -1.58421888595384 1.26958469493711e-05 MirTarget;PITA;miRanda -0.332443568739992 7.2431289530736e-05 NA NA NA hsa-miR-320b KITLG 1.55692969039548 1.41071034251915e-08 -1.58421888595384 1.26958469493711e-05 MirTarget;PITA;miRanda -0.298318886485037 2.31418090290057e-06 NA NA NA hsa-miR-330-3p KITLG 0.876747334239085 0.00073709016089703 -1.58421888595384 1.26958469493711e-05 MirTarget -0.354367135933503 1.46321487291767e-07 NA NA NA hsa-miR-335-3p KITLG 3.08791651139852 5.31309869723517e-12 -1.58421888595384 1.26958469493711e-05 MirTarget -0.21504425067243 1.48720706250474e-08 NA NA NA hsa-miR-33a-3p KITLG 1.72765312072219 1.51784443453521e-07 -1.58421888595384 1.26958469493711e-05 mirMAP -0.268144639312142 3.77355330121851e-06 NA NA NA hsa-miR-345-5p KITLG 3.63532310411307 2.2698112107996e-21 -1.58421888595384 1.26958469493711e-05 MirTarget -0.283518391479385 4.6913558863265e-11 NA NA NA hsa-miR-34a-5p KITLG 1.9016323452565 1.43092834643601e-14 -1.58421888595384 1.26958469493711e-05 MirTarget -0.471477676973797 4.5117297895647e-12 NA NA NA hsa-miR-501-5p KITLG 1.93654809410041 1.3779381780759e-10 -1.58421888595384 1.26958469493711e-05 PITA;mirMAP -0.197041237116664 0.000870835645630206 NA NA NA hsa-miR-589-3p KITLG 2.51971841868825 2.39125940264107e-11 -1.58421888595384 1.26958469493711e-05 mirMAP -0.174939960687697 0.000795488188834909 NA NA NA hsa-miR-590-3p KITLG 2.59289455139753 1.03200520972022e-21 -1.58421888595384 1.26958469493711e-05 MirTarget;PITA;miRanda -0.268795592510798 2.47160443003287e-05 NA NA NA hsa-miR-664a-3p KITLG 0.634721925861133 0.00520070178640421 -1.58421888595384 1.26958469493711e-05 mirMAP -0.588211133806444 1.00835052830132e-14 NA NA NA hsa-miR-7-1-3p KITLG 1.84950311431067 1.25300363397654e-13 -1.58421888595384 1.26958469493711e-05 mirMAP -0.239879555952607 0.000514707164304739 NA NA NA hsa-miR-125a-5p KSR1 0.599529391575274 0.0102300147180307 -0.329087326103332 0.188667705771067 miRanda;mirMAP -0.137754403358718 0.00813458450755502 NA NA NA hsa-miR-30d-5p KSR1 0.675423997639582 0.00270618816039773 -0.329087326103332 0.188667705771067 MirTarget -0.189894985405978 0.000411769253810168 NA NA NA hsa-miR-320a KSR1 0.438165828017084 0.0390159073347133 -0.329087326103332 0.188667705771067 miRanda;mirMAP -0.180771006939551 0.00162397004486748 NA NA NA hsa-let-7a-2-3p KSR2 0.0400317820791161 0.91528727576685 1.26498566961722 0.0739560672368043 mirMAP -0.440014941151508 1.62252424646024e-06 NA NA NA hsa-miR-125b-2-3p KSR2 -1.83175829351767 2.94917958974528e-05 1.26498566961722 0.0739560672368043 mirMAP -0.273458054261785 0.00052270080472449 NA NA NA hsa-miR-132-3p KSR2 0.156276992635384 0.408190812100704 1.26498566961722 0.0739560672368043 mirMAP;miRNATAP -0.539720976769177 0.00332051600909177 NA NA NA hsa-miR-142-5p KSR2 1.17581605694506 0.0018174701991234 1.26498566961722 0.0739560672368043 mirMAP -0.593330329753367 2.09201853185764e-11 NA NA NA hsa-miR-155-5p KSR2 1.20164021433135 0.00086170622431261 1.26498566961722 0.0739560672368043 mirMAP -0.692254280517461 5.04587686358358e-14 NA NA NA hsa-miR-193b-5p KSR2 1.59567208918739 4.89398272459427e-08 1.26498566961722 0.0739560672368043 mirMAP -0.355973022955685 0.00205767621567914 NA NA NA hsa-miR-196a-5p KSR2 1.52993069622497 0.00397268663639603 1.26498566961722 0.0739560672368043 mirMAP -0.285804748228273 7.43861999663094e-06 NA NA NA hsa-miR-199a-3p KSR2 0.640600337515787 0.0380326905134914 1.26498566961722 0.0739560672368043 mirMAP -0.530738895518128 1.42862440078349e-06 NA NA NA hsa-miR-199b-3p KSR2 0.643923492750702 0.0371742251925406 1.26498566961722 0.0739560672368043 mirMAP -0.530536566358238 1.41693396576301e-06 NA NA NA hsa-miR-21-5p KSR2 2.73773305747971 1.38864982139576e-43 1.26498566961722 0.0739560672368043 mirMAP -0.785628335496841 4.3604650282411e-07 NA NA NA hsa-miR-212-3p KSR2 0.357878936470387 0.232446214501331 1.26498566961722 0.0739560672368043 mirMAP;miRNATAP -0.529157748939775 3.81030790310961e-06 NA NA NA hsa-miR-22-5p KSR2 1.88011544159252 1.63978222572222e-16 1.26498566961722 0.0739560672368043 mirMAP -0.626683750702044 1.49620063781334e-05 NA NA NA hsa-miR-223-3p KSR2 0.390350910791999 0.345956164976892 1.26498566961722 0.0739560672368043 mirMAP -0.67317971146825 3.15759521867117e-17 NA NA NA hsa-miR-2355-5p KSR2 1.32510310704724 8.25139516692683e-07 1.26498566961722 0.0739560672368043 mirMAP -0.662567913319634 1.11997814701654e-07 NA NA NA hsa-miR-23a-3p KSR2 1.00493340843378 2.55313889288924e-08 1.26498566961722 0.0739560672368043 mirMAP -1.05513694099396 1.60111700701096e-08 NA NA NA hsa-miR-23a-5p KSR2 1.46491071577368 0.000241866585858992 1.26498566961722 0.0739560672368043 mirMAP -0.339786424570635 0.000174435661698157 NA NA NA hsa-miR-29a-3p KSR2 -0.35074463683376 0.161238718982428 1.26498566961722 0.0739560672368043 mirMAP -1.10472218098456 8.96401405162005e-17 NA NA NA hsa-miR-29a-5p KSR2 1.46749674755271 3.34605004270294e-07 1.26498566961722 0.0739560672368043 mirMAP -0.795959457840663 7.36796374863557e-11 NA NA NA hsa-miR-34c-3p KSR2 2.41359195938096 3.46966584087088e-10 1.26498566961722 0.0739560672368043 mirMAP -0.480273590601038 7.65410668349333e-08 NA NA NA hsa-miR-452-3p KSR2 2.42521958420768 4.08754552781156e-07 1.26498566961722 0.0739560672368043 mirMAP -0.185573590747145 0.00884155234710399 NA NA NA hsa-miR-452-5p KSR2 1.37180058737183 0.00171494843537772 1.26498566961722 0.0739560672368043 mirMAP -0.243117697302941 0.00178547981658182 NA NA NA hsa-miR-455-5p KSR2 2.2582442061694 1.43472128037398e-13 1.26498566961722 0.0739560672368043 mirMAP -0.393334146929572 0.000297565822403284 NA NA NA hsa-miR-629-3p KSR2 2.36570947321815 1.33458201201618e-11 1.26498566961722 0.0739560672368043 mirMAP -0.357532635636933 0.000934466494790163 NA NA NA hsa-miR-101-3p MAP2K1 0.522819989585461 0.00375627731618038 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.179174585612232 2.32589570104786e-07 NA NA NA hsa-miR-30c-5p MAP2K1 0.778774633108 0.000285599212429136 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.1435696131991 6.86626187272449e-07 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-miR-130a-3p MAPK10 2.02021855058359 1.26427102520415e-11 -1.39613685607096 0.000971935890100464 miRNATAP -0.425271273370886 1.25010595009869e-10 NA NA NA hsa-miR-130b-3p MAPK10 3.5350292994509 1.73934183852569e-27 -1.39613685607096 0.000971935890100464 miRNATAP -0.157308872211673 0.00795632424961394 NA NA NA hsa-miR-146b-5p MAPK10 1.75587235896724 1.15724631266659e-07 -1.39613685607096 0.000971935890100464 miRanda -0.590131350156063 2.34286000506143e-24 NA NA NA hsa-miR-193a-3p MAPK10 1.60460546928078 2.86169793322984e-07 -1.39613685607096 0.000971935890100464 miRanda;miRNATAP -0.42329172270216 2.92418176925891e-11 NA NA NA hsa-miR-19a-3p MAPK10 3.42309334186656 3.02671914353412e-28 -1.39613685607096 0.000971935890100464 miRNATAP -0.250292411807473 4.93781898025515e-05 NA NA NA hsa-miR-19b-3p MAPK10 2.49529833021187 1.57028265846699e-23 -1.39613685607096 0.000971935890100464 miRNATAP -0.229843185806225 0.00332174049363652 NA NA NA hsa-miR-221-3p MAPK10 0.451556679024397 0.0909808299917811 -1.39613685607096 0.000971935890100464 miRNATAP -0.397173855876525 2.05290544452981e-07 NA NA NA hsa-miR-222-3p MAPK10 0.851783756239071 0.00266783568486918 -1.39613685607096 0.000971935890100464 miRNATAP -0.438283382047286 7.66762618038364e-10 NA NA NA hsa-miR-29a-3p MAPK10 -0.35074463683376 0.161238718982428 -1.39613685607096 0.000971935890100464 miRNATAP -0.454036231063091 2.56598108627441e-08 NA NA NA hsa-miR-454-3p MAPK10 2.47234127820054 1.12878018736016e-21 -1.39613685607096 0.000971935890100464 miRNATAP -0.209297634977375 0.00734798897159457 NA NA NA hsa-miR-455-5p MAPK10 2.2582442061694 1.43472128037398e-13 -1.39613685607096 0.000971935890100464 miRanda -0.32061697262034 7.65297587236286e-07 NA NA NA hsa-miR-590-3p MAPK10 2.59289455139753 1.03200520972022e-21 -1.39613685607096 0.000971935890100464 miRanda;mirMAP -0.317298220210079 1.7873353325919e-05 NA NA NA hsa-miR-590-5p MAPK10 3.18300989862077 2.06813568597893e-26 -1.39613685607096 0.000971935890100464 PITA;miRanda;miRNATAP -0.243164269697615 0.00024023443868175 NA NA NA hsa-miR-125a-5p MAPK8 0.599529391575274 0.0102300147180307 -0.0756707943151755 0.760488436744535 miRNAWalker2_validate -0.204776391145867 6.53898244404679e-05 NA NA NA hsa-miR-195-3p MAPK8 -0.658653229922836 0.0142127125129199 -0.0756707943151755 0.760488436744535 mirMAP -0.125052773381987 0.00597119043582991 NA NA NA hsa-miR-30c-5p MAPK8 0.778774633108 0.000285599212429136 -0.0756707943151755 0.760488436744535 mirMAP -0.232507239110947 2.92068982830542e-05 NA NA NA hsa-miR-30e-5p MAPK8 1.23904909539663 1.35561917122157e-09 -0.0756707943151755 0.760488436744535 mirMAP -0.151898721585445 0.00886264348901288 NA NA NA hsa-miR-361-5p MAPK9 0.971859117235239 5.30236555707088e-09 -0.269800666047329 0.00867453220223943 miRanda -0.122061441096387 3.51350695967922e-05 NA NA NA hsa-miR-139-5p MET -1.52606598644743 1.20474151350665e-08 0.837921883229614 0.00151106668605525 miRanda -0.150181339310228 0.0014579314310779 NA NA NA hsa-miR-23b-3p MET -0.251132426825047 0.150200321210792 0.837921883229614 0.00151106668605525 miRNAWalker2_validate;miRTarBase -0.255547305484638 0.000600589642295463 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30e-3p MET -0.215663037684509 0.235375122783546 0.837921883229614 0.00151106668605525 mirMAP -0.185298092546442 0.00970912795928673 NA NA NA hsa-let-7a-5p MRAS 0.618599506841644 2.76973453058748e-05 -1.30047814978706 1.21141012267765e-05 mirMAP -0.737681667973198 2.65059909084462e-14 NA NA NA hsa-let-7b-5p MRAS 0.604314269683977 0.00140009936153214 -1.30047814978706 1.21141012267765e-05 mirMAP -0.421401696370699 3.34272798505785e-08 NA NA NA hsa-let-7e-5p MRAS 0.860104282510173 6.04758298373779e-05 -1.30047814978706 1.21141012267765e-05 mirMAP -0.309417830323945 4.12675966259557e-06 NA NA NA hsa-let-7f-5p MRAS 0.495648727272215 0.00355972741198794 -1.30047814978706 1.21141012267765e-05 mirMAP -0.408058271047108 1.92710243502986e-06 NA NA NA hsa-let-7g-5p MRAS 1.20061455355116 1.50237505511483e-12 -1.30047814978706 1.21141012267765e-05 mirMAP -0.599701377167044 3.15678660013671e-13 NA NA NA hsa-miR-103a-2-5p MRAS 2.47599305985086 7.933028987326e-11 -1.30047814978706 1.21141012267765e-05 mirMAP -0.25217082871927 1.19283853976295e-09 NA NA NA hsa-miR-130b-5p MRAS 2.9963110846538 1.98883029416455e-18 -1.30047814978706 1.21141012267765e-05 mirMAP -0.289897227649461 1.13137652927431e-12 NA NA NA hsa-miR-135b-5p MRAS 3.62510365056501 1.09148980810091e-10 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.180245710762348 5.14985019200415e-12 NA NA NA hsa-miR-15a-5p MRAS 2.34669284378787 1.69544424500258e-23 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.45980337367306 5.76913835322092e-16 NA NA NA hsa-miR-15b-5p MRAS 1.57112623124278 9.14247846750597e-13 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.434429767439064 6.05126114923253e-12 NA NA NA hsa-miR-16-5p MRAS 1.75824877145857 1.68592440033108e-16 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.454395779907281 1.77488308069132e-12 NA NA NA hsa-miR-182-5p MRAS 3.53923166221814 5.07781258121574e-21 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.350262585535789 7.07903170837591e-24 NA NA NA hsa-miR-26b-5p MRAS 0.885393662798425 3.2116297961629e-06 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.584244090580643 2.90430804252354e-15 NA NA NA hsa-miR-29b-3p MRAS 1.65828197923813 1.02676780888141e-09 -1.30047814978706 1.21141012267765e-05 mirMAP -0.303920389894105 4.23528221680215e-09 NA NA NA hsa-miR-29c-3p MRAS -0.00968972577705429 0.97099586346872 -1.30047814978706 1.21141012267765e-05 mirMAP -0.287995222844604 1.02353082231546e-07 NA NA NA hsa-miR-3065-3p MRAS 2.16221780121195 9.65525739884541e-09 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.148546650601488 7.9750551259462e-05 NA NA NA hsa-miR-3065-5p MRAS 2.74629919868982 1.86846589298284e-08 -1.30047814978706 1.21141012267765e-05 mirMAP -0.118166519830265 0.000944780125505612 NA NA NA hsa-miR-30d-3p MRAS 0.977747550180601 4.3048212205381e-05 -1.30047814978706 1.21141012267765e-05 mirMAP -0.526035636041477 1.35954231297635e-19 NA NA NA hsa-miR-30e-3p MRAS -0.215663037684509 0.235375122783546 -1.30047814978706 1.21141012267765e-05 mirMAP -0.428667444839994 8.53486300853544e-08 NA NA NA hsa-miR-32-3p MRAS 2.02436999565685 5.94091197945307e-09 -1.30047814978706 1.21141012267765e-05 mirMAP -0.256609855895682 2.70603187488454e-08 NA NA NA hsa-miR-324-5p MRAS 2.95683728155095 1.32960514360912e-20 -1.30047814978706 1.21141012267765e-05 miRanda -0.27549030650863 1.12663330164637e-10 NA NA NA hsa-miR-330-5p MRAS 1.15100069700871 4.85551805046014e-07 -1.30047814978706 1.21141012267765e-05 miRanda -0.27628519059916 1.02211579014909e-05 NA NA NA hsa-miR-335-3p MRAS 3.08791651139852 5.31309869723517e-12 -1.30047814978706 1.21141012267765e-05 mirMAP -0.186397976666785 1.86081571959519e-09 NA NA NA hsa-miR-33a-3p MRAS 1.72765312072219 1.51784443453521e-07 -1.30047814978706 1.21141012267765e-05 mirMAP -0.365378725110188 3.28248890077898e-15 NA NA NA hsa-miR-423-5p MRAS 0.963563145758616 9.86109015204915e-07 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.542171663981532 3.35780208769606e-14 NA NA NA hsa-miR-429 MRAS 4.48815175680773 2.44117492218206e-17 -1.30047814978706 1.21141012267765e-05 miRanda;miRNATAP -0.305396439739903 6.04252534633424e-37 NA NA NA hsa-miR-582-5p MRAS 0.609226359812689 0.032988717891497 -1.30047814978706 1.21141012267765e-05 mirMAP -0.337091970550026 1.25452329198951e-11 NA NA NA hsa-miR-652-3p MRAS 2.16948080686801 4.80670949499399e-18 -1.30047814978706 1.21141012267765e-05 miRNAWalker2_validate -0.42170915650208 6.48104470006076e-15 NA NA NA hsa-miR-7-1-3p MRAS 1.84950311431067 1.25300363397654e-13 -1.30047814978706 1.21141012267765e-05 mirMAP -0.298257826702854 1.00988026513502e-07 NA NA NA hsa-miR-96-5p MRAS 4.89433085814374 1.92000659886961e-31 -1.30047814978706 1.21141012267765e-05 TargetScan;miRNATAP -0.302216752307352 4.73723387400993e-22 NA NA NA hsa-miR-98-5p MRAS 1.11154309866014 1.24143909012085e-08 -1.30047814978706 1.21141012267765e-05 mirMAP -0.423067513772563 6.05526058843975e-09 NA NA NA hsa-miR-139-5p NF1 -1.52606598644743 1.20474151350665e-08 0.0732194429255477 0.645307074955048 miRanda -0.110526489258454 8.37834467200425e-05 NA NA NA hsa-miR-146b-5p NF1 1.75587235896724 1.15724631266659e-07 0.0732194429255477 0.645307074955048 miRanda -0.127547138294409 1.4081291682613e-08 NA NA NA hsa-miR-29a-5p NF1 1.46749674755271 3.34605004270294e-07 0.0732194429255477 0.645307074955048 MirTarget;miRNATAP -0.129236767489049 2.95778906260816e-06 NA NA NA hsa-miR-30a-5p NF1 -0.878357906436456 0.000509952992366057 0.0732194429255477 0.645307074955048 MirTarget;mirMAP;miRNATAP -0.122903163063386 4.5532399319875e-05 NA NA NA hsa-miR-362-3p NF1 2.0756816987665 3.89026064579331e-12 0.0732194429255477 0.645307074955048 miRanda -0.121933419104743 1.95266011585564e-06 NA NA NA hsa-miR-450b-5p NFKB1 1.69244418548325 1.68064054148881e-10 -0.64818153460532 4.948433163113e-05 MirTarget;PITA -0.124463449584444 1.35101416784659e-05 NA NA NA hsa-miR-92a-3p NFKB1 2.06460102658973 1.44784291084757e-19 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.146602812476967 6.42472618908431e-06 NA NA NA hsa-let-7a-5p NGF 0.618599506841644 2.76973453058748e-05 -2.40747957908931 8.29529053936123e-07 MirTarget;TargetScan -0.725600120025055 8.99703032904097e-06 NA NA NA hsa-let-7b-5p NGF 0.604314269683977 0.00140009936153214 -2.40747957908931 8.29529053936123e-07 MirTarget -0.445902124296935 0.000457128474125706 NA NA NA hsa-let-7d-5p NGF 1.33236798905207 1.1741085658466e-13 -2.40747957908931 8.29529053936123e-07 MirTarget -0.678554815907685 1.63174808684775e-07 NA NA NA hsa-let-7e-5p NGF 0.860104282510173 6.04758298373779e-05 -2.40747957908931 8.29529053936123e-07 MirTarget -0.426192872238101 0.000127971345995895 NA NA NA hsa-let-7f-5p NGF 0.495648727272215 0.00355972741198794 -2.40747957908931 8.29529053936123e-07 MirTarget -0.599266844830758 2.3727191387735e-05 NA NA NA hsa-let-7g-5p NGF 1.20061455355116 1.50237505511483e-12 -2.40747957908931 8.29529053936123e-07 MirTarget -1.06245785714021 3.64026543085871e-15 NA NA NA hsa-miR-125a-3p NGF 1.24490295132072 5.26925231010328e-06 -2.40747957908931 8.29529053936123e-07 miRanda -0.250797549188537 0.00395961103629666 NA NA NA hsa-miR-320a NGF 0.438165828017084 0.0390159073347133 -2.40747957908931 8.29529053936123e-07 miRanda -0.444107483987704 8.7035614427142e-05 NA NA NA hsa-miR-320b NGF 1.55692969039548 1.41071034251915e-08 -2.40747957908931 8.29529053936123e-07 miRanda -0.423772071383533 6.50389232533904e-07 NA NA NA hsa-miR-423-5p NGF 0.963563145758616 9.86109015204915e-07 -2.40747957908931 8.29529053936123e-07 MirTarget;miRNATAP -0.803354433746443 1.32594577043773e-11 NA NA NA hsa-miR-429 NGF 4.48815175680773 2.44117492218206e-17 -2.40747957908931 8.29529053936123e-07 miRanda -0.382290239888962 2.67088438561565e-20 NA NA NA hsa-miR-98-5p NGF 1.11154309866014 1.24143909012085e-08 -2.40747957908931 8.29529053936123e-07 MirTarget -0.660953034981452 3.88812196488546e-08 NA NA NA hsa-miR-10a-5p NGFR 1.15016989191194 0.00372037233992369 -2.71562668756498 2.85979409356053e-06 mirMAP -0.349830558159561 7.34289826499961e-07 NA NA NA hsa-miR-148b-5p NGFR 2.18024067300781 2.84770452413262e-14 -2.71562668756498 2.85979409356053e-06 mirMAP -0.704312299780778 1.27912758313244e-12 NA NA NA hsa-miR-15b-3p NGFR 2.33847028227712 4.29662877950836e-19 -2.71562668756498 2.85979409356053e-06 mirMAP -0.744011627633713 2.10872087483696e-13 NA NA NA hsa-miR-185-3p NGFR 2.3922478518806 1.3373426768452e-14 -2.71562668756498 2.85979409356053e-06 miRNATAP -0.562726263803502 9.25850438395162e-11 NA NA NA hsa-miR-2110 NGFR 1.16625590651194 6.4784195289885e-05 -2.71562668756498 2.85979409356053e-06 mirMAP -0.550462813515311 8.4806966972975e-08 NA NA NA hsa-miR-30b-3p NGFR 0.834142820354026 0.000972582820878813 -2.71562668756498 2.85979409356053e-06 mirMAP -0.509892987476281 5.30030705709418e-06 NA NA NA hsa-miR-324-5p NGFR 2.95683728155095 1.32960514360912e-20 -2.71562668756498 2.85979409356053e-06 miRanda -0.625160382556244 4.47533262755334e-14 NA NA NA hsa-miR-326 NGFR 0.715313016136042 0.0610265683213359 -2.71562668756498 2.85979409356053e-06 miRanda;mirMAP -0.206756853583392 0.00563433618434518 NA NA NA hsa-miR-330-5p NGFR 1.15100069700871 4.85551805046014e-07 -2.71562668756498 2.85979409356053e-06 miRanda;mirMAP;miRNATAP -0.426646939175543 0.000526043332395512 NA NA NA hsa-miR-335-5p NGFR 1.77247705492746 2.22457658872091e-06 -2.71562668756498 2.85979409356053e-06 miRNAWalker2_validate -0.291559067143429 9.30146106620593e-05 NA NA NA hsa-miR-342-5p NGFR 1.74634624752902 3.89286511372155e-11 -2.71562668756498 2.85979409356053e-06 mirMAP -0.386119166659559 0.000239223466663646 NA NA NA hsa-miR-34a-5p NGFR 1.9016323452565 1.43092834643601e-14 -2.71562668756498 2.85979409356053e-06 mirMAP -0.651447322603427 3.13859594639451e-09 NA NA NA hsa-miR-429 NGFR 4.48815175680773 2.44117492218206e-17 -2.71562668756498 2.85979409356053e-06 miRNATAP -0.511940678313265 3.59791729760487e-26 NA NA NA hsa-miR-29c-3p NRAS -0.00968972577705429 0.97099586346872 0.638705716882092 3.80929355945655e-05 miRNATAP -0.151007715222895 7.79757166468808e-08 NA NA NA hsa-miR-664a-3p NRAS 0.634721925861133 0.00520070178640421 0.638705716882092 3.80929355945655e-05 MirTarget -0.156789929856636 2.10592676639858e-06 NA NA NA hsa-miR-142-3p NTF3 2.75247908790621 1.45636065474764e-12 -3.30762378554694 2.95059143066034e-13 miRanda -0.289559750333271 2.18084109404098e-07 NA NA NA hsa-miR-21-5p NTF3 2.73773305747971 1.38864982139576e-43 -3.30762378554694 2.95059143066034e-13 miRTarBase;miRNATAP -0.718377718022019 1.14136463226806e-12 NA NA NA hsa-miR-221-3p NTF3 0.451556679024397 0.0909808299917811 -3.30762378554694 2.95059143066034e-13 miRNATAP -0.464707209676713 2.88362012880969e-08 NA NA NA hsa-miR-222-3p NTF3 0.851783756239071 0.00266783568486918 -3.30762378554694 2.95059143066034e-13 miRNATAP -0.529220907365481 1.05244018417693e-11 NA NA NA hsa-miR-421 NTF3 1.17791565395543 6.78526676976629e-06 -3.30762378554694 2.95059143066034e-13 miRanda -0.227952411175781 0.00806835785015479 NA NA NA hsa-miR-590-3p NTF3 2.59289455139753 1.03200520972022e-21 -3.30762378554694 2.95059143066034e-13 miRanda -0.340175587260053 2.82489458563848e-05 NA NA NA hsa-miR-590-5p NTF3 3.18300989862077 2.06813568597893e-26 -3.30762378554694 2.95059143066034e-13 PITA;miRanda;miRNATAP -0.33125375143849 4.71667151153976e-06 NA NA NA hsa-miR-107 NTRK2 1.30977326593435 1.30372468603965e-11 -3.4444884279512 9.02401971614574e-08 PITA;miRanda -1.10328807131129 2.46161403963682e-12 NA NA NA hsa-miR-125a-3p NTRK2 1.24490295132072 5.26925231010328e-06 -3.4444884279512 9.02401971614574e-08 miRanda -0.376033016875365 0.00107171920041796 NA NA NA hsa-miR-126-5p NTRK2 0.895338176458417 2.33372756450713e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.461947070179665 0.00199468881131289 NA NA NA hsa-miR-130b-3p NTRK2 3.5350292994509 1.73934183852569e-27 -3.4444884279512 9.02401971614574e-08 mirMAP -0.655009379767134 1.53407544109055e-13 NA NA NA hsa-miR-130b-5p NTRK2 2.9963110846538 1.98883029416455e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.664721546737953 6.35250159481337e-14 NA NA NA hsa-miR-151a-5p NTRK2 2.32422038747303 2.66226949101065e-18 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.871234808600496 3.71142225770198e-15 NA NA NA hsa-miR-15b-3p NTRK2 2.33847028227712 4.29662877950836e-19 -3.4444884279512 9.02401971614574e-08 mirMAP -0.78865263855268 3.47760542097815e-12 NA NA NA hsa-miR-17-3p NTRK2 2.2704817679209 1.1667437320211e-22 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.986404899520973 5.60866733893115e-15 NA NA NA hsa-miR-181a-5p NTRK2 2.29556023480783 1.8138457900616e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.641712336343684 2.29468859355526e-07 NA NA NA hsa-miR-181b-5p NTRK2 2.49307679431293 3.92829250217627e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.623644911740744 1.48869667340713e-08 NA NA NA hsa-miR-181c-5p NTRK2 1.58587920618301 1.57506918816933e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.487056006099362 9.7916777419054e-05 NA NA NA hsa-miR-182-5p NTRK2 3.53923166221814 5.07781258121574e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.542854638305866 3.89545557204651e-12 NA NA NA hsa-miR-185-5p NTRK2 2.34016206907488 1.17481626642022e-26 -3.4444884279512 9.02401971614574e-08 mirMAP -0.908221744534185 1.04154350912728e-11 NA NA NA hsa-miR-186-5p NTRK2 1.47445398888668 3.0781726595413e-15 -3.4444884279512 9.02401971614574e-08 mirMAP -1.08361132863423 2.28591646607224e-11 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 2.92621109947706 2.49504904635375e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.638958030834559 4.2820526373737e-13 NA NA NA hsa-miR-21-5p NTRK2 2.73773305747971 1.38864982139576e-43 -3.4444884279512 9.02401971614574e-08 mirMAP -0.426222870969759 0.00330777931884449 NA NA NA hsa-miR-22-3p NTRK2 1.21545661147757 1.61670170137775e-13 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.792113978350115 2.65895272261461e-05 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-224-3p NTRK2 1.87536386559317 6.15140969394846e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.251953296536257 0.000320280319633908 NA NA NA hsa-miR-26b-5p NTRK2 0.885393662798425 3.2116297961629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.918548097668709 2.31015434348151e-08 NA NA NA hsa-miR-29a-5p NTRK2 1.46749674755271 3.34605004270294e-07 -3.4444884279512 9.02401971614574e-08 mirMAP -0.413787908321922 0.000315700519378732 NA NA NA hsa-miR-301a-3p NTRK2 2.81024345929638 2.29784847962242e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.744969523901533 2.39919848998948e-15 NA NA NA hsa-miR-3065-5p NTRK2 2.74629919868982 1.86846589298284e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.286324800403609 0.00023527787223171 NA NA NA hsa-miR-30b-5p NTRK2 0.800822374912712 0.000133601914525413 -3.4444884279512 9.02401971614574e-08 mirMAP -0.546689649319654 0.00029099120653431 NA NA NA hsa-miR-30c-5p NTRK2 0.778774633108 0.000285599212429136 -3.4444884279512 9.02401971614574e-08 mirMAP -0.689336493365858 2.58508921415882e-06 NA NA NA hsa-miR-30d-3p NTRK2 0.977747550180601 4.3048212205381e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.665503813522632 3.72555641617031e-07 NA NA NA hsa-miR-30d-5p NTRK2 0.675423997639582 0.00270618816039773 -3.4444884279512 9.02401971614574e-08 mirMAP -0.687091926033502 8.8466750322348e-07 NA NA NA hsa-miR-30e-3p NTRK2 -0.215663037684509 0.235375122783546 -3.4444884279512 9.02401971614574e-08 mirMAP -0.560142851781332 0.00151121456503575 NA NA NA hsa-miR-30e-5p NTRK2 1.23904909539663 1.35561917122157e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.997379711717577 3.00290798335836e-11 NA NA NA hsa-miR-32-3p NTRK2 2.02436999565685 5.94091197945307e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.59869849424457 2.50361692819518e-09 NA NA NA hsa-miR-32-5p NTRK2 2.34056473219422 6.24134585974322e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.794984558850216 6.67646054442438e-12 NA NA NA hsa-miR-320a NTRK2 0.438165828017084 0.0390159073347133 -3.4444884279512 9.02401971614574e-08 mirMAP -0.708471038497037 2.00258734327495e-06 NA NA NA hsa-miR-320b NTRK2 1.55692969039548 1.41071034251915e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.748159964114521 1.79959199577157e-11 NA NA NA hsa-miR-326 NTRK2 0.715313016136042 0.0610265683213359 -3.4444884279512 9.02401971614574e-08 miRanda -0.314908565253097 0.000146783251679974 NA NA NA hsa-miR-330-5p NTRK2 1.15100069700871 4.85551805046014e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.797396566610236 3.87824675584644e-09 NA NA NA hsa-miR-335-3p NTRK2 3.08791651139852 5.31309869723517e-12 -3.4444884279512 9.02401971614574e-08 mirMAP -0.325799033294531 1.77950710082574e-06 NA NA NA hsa-miR-335-5p NTRK2 1.77247705492746 2.22457658872091e-06 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate -0.306339245672051 0.000234367118729164 NA NA NA hsa-miR-339-5p NTRK2 2.68710938429893 3.03134080808154e-16 -3.4444884279512 9.02401971614574e-08 miRanda -0.473102823273484 2.60419080375085e-07 NA NA NA hsa-miR-33a-5p NTRK2 3.79671563098419 1.15966309820345e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.446714130551512 3.20996972838069e-09 NA NA NA hsa-miR-34a-3p NTRK2 1.75590866103657 8.02801510630657e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.545493213319934 1.33340706209908e-06 NA NA NA hsa-miR-361-5p NTRK2 0.971859117235239 5.30236555707088e-09 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -1.17870891609401 2.52271895231875e-10 NA NA NA hsa-miR-362-5p NTRK2 1.59303749908759 9.582675908797e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.34256739087268 0.0010450304175508 NA NA NA hsa-miR-421 NTRK2 1.17791565395543 6.78526676976629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.388652077576734 0.00124164792398222 NA NA NA hsa-miR-429 NTRK2 4.48815175680773 2.44117492218206e-17 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;miRNATAP -0.439212754909065 2.46588001463114e-15 NA NA NA hsa-miR-454-3p NTRK2 2.47234127820054 1.12878018736016e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.84994308142847 3.69480447340161e-13 NA NA NA hsa-miR-455-3p NTRK2 3.06093594997644 3.54590649799868e-16 -3.4444884279512 9.02401971614574e-08 mirMAP -0.417652226788031 2.01737423577491e-07 NA NA NA hsa-miR-501-5p NTRK2 1.93654809410041 1.3779381780759e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.515062812169395 9.14107888272414e-07 NA NA NA hsa-miR-532-5p NTRK2 1.55697650978597 1.57884735535196e-11 -3.4444884279512 9.02401971614574e-08 PITA -0.662294968429731 6.6852568807782e-07 NA NA NA hsa-miR-576-5p NTRK2 2.20467023993664 3.4053475193793e-19 -3.4444884279512 9.02401971614574e-08 PITA;mirMAP -0.790847254437626 6.52457580482194e-11 NA NA NA hsa-miR-590-3p NTRK2 2.59289455139753 1.03200520972022e-21 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;mirMAP -0.620306339153694 4.06542783004907e-08 NA NA NA hsa-miR-590-5p NTRK2 3.18300989862077 2.06813568597893e-26 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -0.735662775454248 1.39412676341035e-13 NA NA NA hsa-miR-940 NTRK2 3.21011374578759 2.7923171128495e-14 -3.4444884279512 9.02401971614574e-08 PITA -0.574117798651102 9.91369577061371e-14 NA NA NA hsa-let-7e-5p PAK1 0.860104282510173 6.04758298373779e-05 -0.260585931173264 0.175229696873286 miRNATAP -0.1369917481953 0.00153436045412213 NA NA NA hsa-miR-149-5p PAK3 2.94200492826326 4.93436498919036e-14 -1.47931429282044 0.00222762803368061 MirTarget;miRNATAP -0.292684646778987 3.88490648155152e-07 NA NA NA hsa-miR-200b-3p PAK3 3.78235093249346 3.18343003239465e-14 -1.47931429282044 0.00222762803368061 TargetScan -0.223367460822547 7.52764068202279e-07 NA NA NA hsa-miR-200c-5p PAK3 2.95761105443819 3.11105707262802e-11 -1.47931429282044 0.00222762803368061 MirTarget;miRNATAP -0.197251856374392 0.000304061274969976 NA NA NA hsa-miR-23a-3p PAK3 1.00493340843378 2.55313889288924e-08 -1.47931429282044 0.00222762803368061 MirTarget -0.721896516767137 1.72432461748779e-08 NA NA NA hsa-miR-455-5p PAK3 2.2582442061694 1.43472128037398e-13 -1.47931429282044 0.00222762803368061 miRanda -0.260821647229484 0.000471193752888812 NA NA NA hsa-miR-96-5p PAK3 4.89433085814374 1.92000659886961e-31 -1.47931429282044 0.00222762803368061 TargetScan -0.169800613276342 0.00141297506337148 NA NA NA hsa-miR-338-5p PAK4 -0.577691606146419 0.0472212680542825 0.903263874551754 2.26152224631644e-08 PITA;miRNATAP -0.106634930499695 9.955386224613e-05 NA NA NA hsa-miR-320b PDGFA 1.55692969039548 1.41071034251915e-08 -0.102054427352152 0.706957288628846 miRanda -0.127864638339372 0.00663582990083202 NA NA NA hsa-miR-331-5p PDGFA 2.17414714166315 1.54547681391888e-18 -0.102054427352152 0.706957288628846 PITA;miRNATAP -0.160783001474425 0.00212874646023858 NA NA NA hsa-miR-421 PDGFA 1.17791565395543 6.78526676976629e-06 -0.102054427352152 0.706957288628846 miRanda -0.169357059547879 0.000668658673908117 NA NA NA hsa-miR-484 PDGFA 1.81844463411787 1.82951571230938e-15 -0.102054427352152 0.706957288628846 PITA;miRNATAP -0.163420399065966 0.00333081226843222 NA NA NA hsa-miR-590-3p PDGFA 2.59289455139753 1.03200520972022e-21 -0.102054427352152 0.706957288628846 miRanda -0.133975078033997 0.0047011572526004 NA NA NA hsa-miR-590-5p PDGFA 3.18300989862077 2.06813568597893e-26 -0.102054427352152 0.706957288628846 miRanda -0.136216823398504 0.00126211188867757 NA NA NA hsa-let-7a-5p PDGFB 0.618599506841644 2.76973453058748e-05 0.496610054270869 0.0653962924185686 TargetScan;miRNATAP -0.34611820876839 0.000105030069604701 NA NA NA hsa-let-7f-5p PDGFB 0.495648727272215 0.00355972741198794 0.496610054270869 0.0653962924185686 miRNATAP -0.230786895213123 0.00294626570770709 NA NA NA hsa-let-7g-5p PDGFB 1.20061455355116 1.50237505511483e-12 0.496610054270869 0.0653962924185686 miRNATAP -0.228771312890516 0.00256055086878667 NA NA NA hsa-miR-29b-2-5p PDGFB 0.910668640983475 0.00666655585493488 0.496610054270869 0.0653962924185686 mirMAP -0.139091152849383 0.000325402180502362 NA NA NA hsa-miR-29c-3p PDGFB -0.00968972577705429 0.97099586346872 0.496610054270869 0.0653962924185686 MirTarget;miRNATAP -0.136061870879976 0.00568361134251952 NA NA NA hsa-miR-16-2-3p PDGFC 2.31623086727196 4.29838149388188e-20 -1.35193216344973 0.000222396841108038 mirMAP -0.381970075069368 1.03844682897972e-08 NA NA NA hsa-miR-330-3p PDGFC 0.876747334239085 0.00073709016089703 -1.35193216344973 0.000222396841108038 mirMAP -0.513212595408201 1.24081468442561e-14 NA NA NA hsa-miR-330-5p PDGFC 1.15100069700871 4.85551805046014e-07 -1.35193216344973 0.000222396841108038 miRanda -0.468820563713005 7.20271419938696e-10 NA NA NA hsa-miR-335-3p PDGFC 3.08791651139852 5.31309869723517e-12 -1.35193216344973 0.000222396841108038 mirMAP -0.235349925814362 6.22897769137172e-10 NA NA NA hsa-miR-3607-3p PDGFC 2.68532138541128 5.66716351955047e-14 -1.35193216344973 0.000222396841108038 mirMAP -0.285687710966463 5.32070657766311e-09 NA NA NA hsa-miR-361-5p PDGFC 0.971859117235239 5.30236555707088e-09 -1.35193216344973 0.000222396841108038 miRanda -0.833081202036927 7.87976775653925e-16 NA NA NA hsa-miR-421 PDGFC 1.17791565395543 6.78526676976629e-06 -1.35193216344973 0.000222396841108038 miRanda -0.351311206292076 1.63831209098356e-07 NA NA NA hsa-miR-486-5p PDGFC -0.194913133034028 0.607377798807705 -1.35193216344973 0.000222396841108038 miRanda -0.178753024306378 0.000136764659737303 NA NA NA hsa-miR-582-3p PDGFC 0.00876844181512659 0.977126166214707 -1.35193216344973 0.000222396841108038 PITA -0.270308220423039 3.19238038538228e-06 NA NA NA hsa-miR-590-3p PDGFC 2.59289455139753 1.03200520972022e-21 -1.35193216344973 0.000222396841108038 PITA;miRanda;mirMAP -0.362163122053015 1.207543102597e-08 NA NA NA hsa-miR-7-1-3p PDGFC 1.84950311431067 1.25300363397654e-13 -1.35193216344973 0.000222396841108038 mirMAP -0.308615311749286 8.0769094309117e-06 NA NA NA hsa-miR-944 PDGFC 2.91186649218281 1.31574753528144e-06 -1.35193216344973 0.000222396841108038 mirMAP -0.231401333838594 2.34241674181651e-15 NA NA NA hsa-miR-19b-1-5p PDGFD 2.57951428759379 4.31576118703427e-20 -2.21895974366423 9.8844535062016e-11 MirTarget -0.371069183482093 1.91682488089415e-10 NA NA NA hsa-miR-21-5p PDGFD 2.73773305747971 1.38864982139576e-43 -2.21895974366423 9.8844535062016e-11 miRNAWalker2_validate -0.550873661766527 3.68515951748985e-13 NA NA NA hsa-miR-320b PDGFD 1.55692969039548 1.41071034251915e-08 -2.21895974366423 9.8844535062016e-11 miRanda -0.182874490877128 0.00270207482500816 NA NA NA hsa-miR-331-5p PDGFD 2.17414714166315 1.54547681391888e-18 -2.21895974366423 9.8844535062016e-11 MirTarget -0.434379532111514 6.49776221649418e-11 NA NA NA hsa-miR-590-3p PDGFD 2.59289455139753 1.03200520972022e-21 -2.21895974366423 9.8844535062016e-11 miRanda;mirMAP;miRNATAP -0.410508831975381 7.9308556547056e-12 NA NA NA hsa-miR-590-5p PDGFD 3.18300989862077 2.06813568597893e-26 -2.21895974366423 9.8844535062016e-11 miRanda -0.358503417217371 2.33094792409083e-11 NA NA NA hsa-miR-7-1-3p PDGFD 1.84950311431067 1.25300363397654e-13 -2.21895974366423 9.8844535062016e-11 mirMAP -0.328505748297511 5.62247042199189e-07 NA NA NA hsa-miR-944 PDGFD 2.91186649218281 1.31574753528144e-06 -2.21895974366423 9.8844535062016e-11 MirTarget;mirMAP -0.207430129373809 1.1380429140574e-13 NA NA NA hsa-let-7a-3p PDGFRA 1.42015538786275 7.03375209382654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.548764001510131 6.84820893227166e-09 NA NA NA hsa-let-7b-3p PDGFRA 0.868207752019623 1.30460056774366e-05 -2.37640583073564 1.39737819859365e-09 mirMAP -0.344538450812629 0.000386110125844406 NA NA NA hsa-let-7b-5p PDGFRA 0.604314269683977 0.00140009936153214 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate -0.521190235799922 3.3085772165913e-07 NA NA NA hsa-let-7f-1-3p PDGFRA 1.55054488387679 7.31326775537952e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.255636194946609 0.00187448794686435 NA NA NA hsa-let-7g-3p PDGFRA 3.26398061402445 3.96263126107645e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.513984859053283 2.05725197047486e-19 NA NA NA hsa-miR-106a-5p PDGFRA 2.48882002962836 1.99757727374521e-12 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.371298633316283 8.91032038900892e-13 NA NA NA hsa-miR-106b-5p PDGFRA 2.46782146831112 1.36171495805632e-23 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.735956870099196 1.34297971882591e-25 NA NA NA hsa-miR-129-5p PDGFRA -0.524170159980738 0.222582956006346 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP;miRNATAP -0.128621152047043 0.0051316212954247 NA NA NA hsa-miR-130a-3p PDGFRA 2.02021855058359 1.26427102520415e-11 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.233330487651072 0.000224564945662775 NA NA NA hsa-miR-130b-3p PDGFRA 3.5350292994509 1.73934183852569e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.443010230539233 1.9085252314885e-16 NA NA NA hsa-miR-141-3p PDGFRA 5.02396127982626 2.19224509139725e-24 -2.37640583073564 1.39737819859365e-09 MirTarget -0.379513640202387 7.11112956696243e-28 NA NA NA hsa-miR-149-5p PDGFRA 2.94200492826326 4.93436498919036e-14 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.2660799579696 1.94629645007035e-08 NA NA NA hsa-miR-16-1-3p PDGFRA 2.56983217111073 3.02262181237943e-20 -2.37640583073564 1.39737819859365e-09 MirTarget -0.523089278771913 2.57639641644736e-15 NA NA NA hsa-miR-17-5p PDGFRA 3.2710598467455 9.93128340539455e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;TargetScan;miRNATAP -0.553748753585946 1.23397121105114e-22 NA NA NA hsa-miR-181b-5p PDGFRA 2.49307679431293 3.92829250217627e-20 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.246762118189355 0.000291477558580384 NA NA NA hsa-miR-182-5p PDGFRA 3.53923166221814 5.07781258121574e-21 -2.37640583073564 1.39737819859365e-09 miRNATAP -0.375439590705967 2.48477058044486e-15 NA NA NA hsa-miR-186-5p PDGFRA 1.47445398888668 3.0781726595413e-15 -2.37640583073564 1.39737819859365e-09 MirTarget -0.700421064109499 1.35088148765239e-12 NA NA NA hsa-miR-196a-5p PDGFRA 1.52993069622497 0.00397268663639603 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.124523334352829 0.000586053454058574 NA NA NA hsa-miR-196b-5p PDGFRA 1.71646270856386 4.37735885910369e-09 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.290309745460117 7.22286389037591e-06 NA NA NA hsa-miR-200a-3p PDGFRA 4.59434485520731 6.38952518573476e-18 -2.37640583073564 1.39737819859365e-09 MirTarget -0.30020684009978 2.24739680558458e-19 NA NA NA hsa-miR-20a-5p PDGFRA 3.15577933619191 4.19753346442454e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.536531231590286 6.48676718494673e-21 NA NA NA hsa-miR-20b-5p PDGFRA 2.07706563022469 1.10107236083433e-05 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.200276264854919 5.98530623190359e-07 NA NA NA hsa-miR-2110 PDGFRA 1.16625590651194 6.4784195289885e-05 -2.37640583073564 1.39737819859365e-09 MirTarget -0.367427900079696 1.6178582537556e-07 NA NA NA hsa-miR-224-5p PDGFRA 2.94107125335675 5.72194099515157e-08 -2.37640583073564 1.39737819859365e-09 MirTarget -0.18329230997559 1.26828530884065e-07 NA NA NA hsa-miR-24-3p PDGFRA 0.99989036772428 1.35595013650376e-07 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.445666887182499 1.04888902991557e-05 NA NA NA hsa-miR-26b-5p PDGFRA 0.885393662798425 3.2116297961629e-06 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.434540118830339 1.79640152621153e-05 NA NA NA hsa-miR-27a-3p PDGFRA 1.66542180327138 4.93775737894805e-13 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.231732831890339 0.00480656820974615 NA NA NA hsa-miR-29b-2-5p PDGFRA 0.910668640983475 0.00666655585493488 -2.37640583073564 1.39737819859365e-09 mirMAP -0.249967909040798 1.27931881284481e-05 NA NA NA hsa-miR-29b-3p PDGFRA 1.65828197923813 1.02676780888141e-09 -2.37640583073564 1.39737819859365e-09 MirTarget -0.200668467003426 0.00420946019654394 NA NA NA hsa-miR-301a-3p PDGFRA 2.81024345929638 2.29784847962242e-17 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.508684565933966 4.36558822645561e-19 NA NA NA hsa-miR-3065-5p PDGFRA 2.74629919868982 1.86846589298284e-08 -2.37640583073564 1.39737819859365e-09 mirMAP -0.166254695248905 0.00048554613178076 NA NA NA hsa-miR-320a PDGFRA 0.438165828017084 0.0390159073347133 -2.37640583073564 1.39737819859365e-09 miRanda -0.402889384468968 1.02856691876917e-05 NA NA NA hsa-miR-320b PDGFRA 1.55692969039548 1.41071034251915e-08 -2.37640583073564 1.39737819859365e-09 miRanda -0.519602099473307 1.42131525257444e-14 NA NA NA hsa-miR-330-5p PDGFRA 1.15100069700871 4.85551805046014e-07 -2.37640583073564 1.39737819859365e-09 miRanda -0.45163495328704 5.41294182541652e-08 NA NA NA hsa-miR-335-3p PDGFRA 3.08791651139852 5.31309869723517e-12 -2.37640583073564 1.39737819859365e-09 mirMAP -0.14687583518123 0.000466962608053098 NA NA NA hsa-miR-339-5p PDGFRA 2.68710938429893 3.03134080808154e-16 -2.37640583073564 1.39737819859365e-09 miRanda -0.338543405646925 1.34989847950552e-09 NA NA NA hsa-miR-33a-5p PDGFRA 3.79671563098419 1.15966309820345e-18 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.396871470489045 1.19728989197256e-18 NA NA NA hsa-miR-34a-5p PDGFRA 1.9016323452565 1.43092834643601e-14 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.295453243484317 9.87541559838975e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA 2.07190852984647 7.35776320806257e-08 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.225762830573297 1.74081263395182e-05 NA NA NA hsa-miR-362-3p PDGFRA 2.0756816987665 3.89026064579331e-12 -2.37640583073564 1.39737819859365e-09 miRanda -0.2120805244561 0.00115047466173652 NA NA NA hsa-miR-374a-5p PDGFRA 0.484615721953736 0.0042981729815149 -2.37640583073564 1.39737819859365e-09 mirMAP -0.336442959314977 0.00360859152849973 NA NA NA hsa-miR-421 PDGFRA 1.17791565395543 6.78526676976629e-06 -2.37640583073564 1.39737819859365e-09 PITA;miRanda;miRNATAP -0.474589953500027 4.96575533912116e-11 NA NA NA hsa-miR-429 PDGFRA 4.48815175680773 2.44117492218206e-17 -2.37640583073564 1.39737819859365e-09 miRanda;miRNATAP -0.283783064999005 4.47719067465487e-17 NA NA NA hsa-miR-454-3p PDGFRA 2.47234127820054 1.12878018736016e-21 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.54069398402006 3.51649522550592e-14 NA NA NA hsa-miR-491-5p PDGFRA 0.615770352820862 0.0418295628761654 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.259675783066868 0.000149579704439114 NA NA NA hsa-miR-550a-5p PDGFRA 2.11025227932763 6.94489556637146e-12 -2.37640583073564 1.39737819859365e-09 MirTarget -0.450686953718593 5.51129161245862e-14 NA NA NA hsa-miR-576-5p PDGFRA 2.20467023993664 3.4053475193793e-19 -2.37640583073564 1.39737819859365e-09 mirMAP -0.494558915423906 2.30135204635613e-11 NA NA NA hsa-miR-589-3p PDGFRA 2.51971841868825 2.39125940264107e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.375875993689772 1.70404670310081e-11 NA NA NA hsa-miR-590-3p PDGFRA 2.59289455139753 1.03200520972022e-21 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP -0.493181031896196 4.96463414718196e-13 NA NA NA hsa-miR-590-5p PDGFRA 3.18300989862077 2.06813568597893e-26 -2.37640583073564 1.39737819859365e-09 miRanda -0.507406338027508 3.77905121698734e-17 NA NA NA hsa-miR-7-1-3p PDGFRA 1.84950311431067 1.25300363397654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.533746456815578 4.42305082401204e-13 NA NA NA hsa-miR-93-5p PDGFRA 3.03961860136032 1.11672209617395e-24 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.564676380038124 7.42892698232966e-22 NA NA NA hsa-miR-944 PDGFRA 2.91186649218281 1.31574753528144e-06 -2.37640583073564 1.39737819859365e-09 mirMAP -0.271450894098107 7.2626459248576e-18 NA NA NA hsa-miR-96-5p PDGFRA 4.89433085814374 1.92000659886961e-31 -2.37640583073564 1.39737819859365e-09 TargetScan;miRNATAP -0.372021838983214 1.0707043407444e-18 NA NA NA hsa-miR-224-5p PDGFRB 2.94107125335675 5.72194099515157e-08 -1.03522303801072 0.00301738788961229 miRNAWalker2_validate -0.147943334000896 1.16237114575095e-06 NA NA NA hsa-miR-24-3p PDGFRB 0.99989036772428 1.35595013650376e-07 -1.03522303801072 0.00301738788961229 MirTarget -0.297654000867495 0.000814454894038923 NA NA NA hsa-miR-29b-3p PDGFRB 1.65828197923813 1.02676780888141e-09 -1.03522303801072 0.00301738788961229 miRNATAP -0.292671948645054 1.48415268440158e-06 NA NA NA hsa-miR-29c-3p PDGFRB -0.00968972577705429 0.97099586346872 -1.03522303801072 0.00301738788961229 miRNATAP -0.359274369001045 1.19150158465265e-08 NA NA NA hsa-miR-3127-5p PDGFRB 1.51846438737133 3.59571251672767e-07 -1.03522303801072 0.00301738788961229 mirMAP -0.437942367228042 7.35571780732733e-16 NA NA NA hsa-miR-34a-5p PDGFRB 1.9016323452565 1.43092834643601e-14 -1.03522303801072 0.00301738788961229 MirTarget -0.3682858109356 2.13745951637981e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-Ī±/Ī² and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 1.07367425434318 1.73142774168958e-09 -1.03522303801072 0.00301738788961229 MirTarget -0.272631369423021 0.00390272618180474 NA NA NA hsa-miR-421 PDGFRB 1.17791565395543 6.78526676976629e-06 -1.03522303801072 0.00301738788961229 miRanda -0.344304119846965 6.47537980961128e-08 NA NA NA hsa-miR-484 PDGFRB 1.81844463411787 1.82951571230938e-15 -1.03522303801072 0.00301738788961229 mirMAP -0.430712318832622 1.16944218559625e-09 NA NA NA hsa-miR-486-5p PDGFRB -0.194913133034028 0.607377798807705 -1.03522303801072 0.00301738788961229 miRanda -0.172192912820644 0.000110418260727812 NA NA NA hsa-miR-491-5p PDGFRB 0.615770352820862 0.0418295628761654 -1.03522303801072 0.00301738788961229 miRanda -0.236736729792446 7.68579463655803e-05 NA NA NA hsa-miR-664a-3p PDGFRB 0.634721925861133 0.00520070178640421 -1.03522303801072 0.00301738788961229 MirTarget -0.524307398841617 6.92902562319671e-13 NA NA NA hsa-miR-9-5p PDGFRB 1.02304182473283 0.042901377604859 -1.03522303801072 0.00301738788961229 MirTarget;miRNATAP -0.128055325842353 0.000120423195513495 NA NA NA hsa-miR-326 PGF 0.715313016136042 0.0610265683213359 0.82580882918736 0.0169544692696931 mirMAP -0.162219493325868 0.000221458535925083 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-324-5p PLA1A 2.95683728155095 1.32960514360912e-20 -0.559375886400689 0.252478300143861 miRanda -0.258362669899933 0.000259401182290384 NA NA NA hsa-miR-486-5p PLA1A -0.194913133034028 0.607377798807705 -0.559375886400689 0.252478300143861 miRanda -0.205995718159769 0.000938303421999265 NA NA NA hsa-miR-140-5p PLA2G12A 0.844753502512594 3.73722278438606e-05 -0.226923565397224 0.110320132886187 miRanda -0.14801862288608 8.44927388616416e-06 NA NA NA hsa-miR-142-3p PLA2G12A 2.75247908790621 1.45636065474764e-12 -0.226923565397224 0.110320132886187 miRanda -0.132479438643194 1.31230119499281e-15 NA NA NA hsa-miR-142-5p PLA2G12A 1.17581605694506 0.0018174701991234 -0.226923565397224 0.110320132886187 mirMAP -0.152006113752674 2.16543248749224e-18 NA NA NA hsa-miR-29a-5p PLA2G12A 1.46749674755271 3.34605004270294e-07 -0.226923565397224 0.110320132886187 mirMAP -0.162300143536253 2.86585419004462e-11 NA NA NA hsa-miR-129-5p PLA2G16 -0.524170159980738 0.222582956006346 -0.465134101583985 0.33256579053472 miRanda -0.224374770297617 4.19632845245939e-05 NA NA NA hsa-miR-590-3p PLA2G16 2.59289455139753 1.03200520972022e-21 -0.465134101583985 0.33256579053472 miRanda;mirMAP -0.284872552699921 0.000669313407826871 NA NA NA hsa-miR-590-5p PLA2G16 3.18300989862077 2.06813568597893e-26 -0.465134101583985 0.33256579053472 miRanda -0.222865057511879 0.00291312208219953 NA NA NA hsa-miR-361-5p PLA2G2A 0.971859117235239 5.30236555707088e-09 -3.40473736904758 6.12351716198306e-05 miRanda -1.54030311209047 2.69460491948461e-10 NA NA NA hsa-miR-491-5p PLA2G2A 0.615770352820862 0.0418295628761654 -3.40473736904758 6.12351716198306e-05 miRanda -0.808306666640749 2.54440652464924e-08 NA NA NA hsa-miR-15a-5p PLA2G2D 2.34669284378787 1.69544424500258e-23 -1.02276507955976 0.189798951526849 miRNAWalker2_validate -0.404850472000017 0.00807397819916615 NA NA NA hsa-miR-16-1-3p PLA2G2D 2.56983217111073 3.02262181237943e-20 -1.02276507955976 0.189798951526849 mirMAP -0.48415802760318 0.000261010539116146 NA NA NA hsa-miR-125b-5p PLA2G2F -1.16462950151259 0.000288900271798384 3.13177891691247 0.00146365751535567 mirMAP -0.775103233945353 1.21552641246288e-07 NA NA NA hsa-miR-18a-3p PLA2G2F 2.14813400940323 2.23460809936028e-06 3.13177891691247 0.00146365751535567 mirMAP -0.485063580878413 0.000219436625550264 NA NA NA hsa-miR-2355-5p PLA2G2F 1.32510310704724 8.25139516692683e-07 3.13177891691247 0.00146365751535567 MirTarget -0.725846284205262 3.52692947225181e-05 NA NA NA hsa-miR-1301-3p PLA2G4A 2.54959518791507 5.26618591274892e-18 -1.76911972497501 1.36780052043494e-06 MirTarget -0.271432528908166 2.86828986780574e-06 NA NA NA hsa-miR-142-3p PLA2G4A 2.75247908790621 1.45636065474764e-12 -1.76911972497501 1.36780052043494e-06 miRanda -0.13710181671413 0.00221782421174375 NA NA NA hsa-miR-146b-5p PLA2G4A 1.75587235896724 1.15724631266659e-07 -1.76911972497501 1.36780052043494e-06 miRNAWalker2_validate -0.138508703164524 0.00953802605681816 NA NA NA hsa-miR-181a-5p PLA2G4A 2.29556023480783 1.8138457900616e-21 -1.76911972497501 1.36780052043494e-06 MirTarget -0.210530558529152 0.00302794528753118 NA NA NA hsa-miR-181c-5p PLA2G4A 1.58587920618301 1.57506918816933e-10 -1.76911972497501 1.36780052043494e-06 MirTarget -0.263675364814697 0.000199093485008343 NA NA NA hsa-miR-181d-5p PLA2G4A 1.52204912185579 9.2693319057748e-08 -1.76911972497501 1.36780052043494e-06 MirTarget -0.190977664531932 0.00213336065376659 NA NA NA hsa-miR-33a-3p PLA2G4A 1.72765312072219 1.51784443453521e-07 -1.76911972497501 1.36780052043494e-06 MirTarget -0.156816958703784 0.00805830236676267 NA NA NA hsa-miR-361-5p PLA2G4A 0.971859117235239 5.30236555707088e-09 -1.76911972497501 1.36780052043494e-06 miRanda -0.44352221685407 3.38401198401618e-05 NA NA NA hsa-miR-362-3p PLA2G4A 2.0756816987665 3.89026064579331e-12 -1.76911972497501 1.36780052043494e-06 miRanda -0.344359237218545 7.62718654263185e-09 NA NA NA hsa-miR-590-3p PLA2G4A 2.59289455139753 1.03200520972022e-21 -1.76911972497501 1.36780052043494e-06 miRanda -0.330281844381331 2.6395869433225e-07 NA NA NA hsa-miR-107 PLA2G4C 1.30977326593435 1.30372468603965e-11 -1.87013584640366 1.38630177184505e-06 miRanda -0.718483287042936 1.91344639038854e-14 NA NA NA hsa-miR-146b-5p PLA2G4D 1.75587235896724 1.15724631266659e-07 0.150630495729409 0.803070562793874 miRanda -0.333370812346294 0.000116943101126114 NA NA NA hsa-miR-199a-5p PLA2G4D 0.592984035153911 0.0674836634175293 0.150630495729409 0.803070562793874 miRanda -0.3334651039018 0.000203283296281199 NA NA NA hsa-miR-664a-3p PLA2G4E 0.634721925861133 0.00520070178640421 -0.457051657544898 0.526340607142826 mirMAP -0.528605473505062 0.000587247707984126 NA NA NA hsa-miR-125b-5p PLA2G4F -1.16462950151259 0.000288900271798384 1.59101464346938 0.01196658357001 miRNAWalker2_validate -0.462727277875434 9.03682006952861e-07 NA NA NA hsa-miR-125a-5p PLA2G5 0.599529391575274 0.0102300147180307 -2.98039017984699 5.45430675918713e-08 miRanda -0.43402319502752 0.000171953535886849 NA NA NA hsa-miR-128-3p PLA2G5 1.63756041666078 6.79626586407187e-14 -2.98039017984699 5.45430675918713e-08 miRNAWalker2_validate -1.13154129122494 4.25362784424371e-23 NA NA NA hsa-miR-330-5p PLA2G5 1.15100069700871 4.85551805046014e-07 -2.98039017984699 5.45430675918713e-08 miRanda -0.87956954375258 9.6120825351781e-15 NA NA NA hsa-miR-339-5p PLA2G5 2.68710938429893 3.03134080808154e-16 -2.98039017984699 5.45430675918713e-08 miRanda -0.538476541600716 3.05043859695343e-12 NA NA NA hsa-miR-361-5p PLA2G5 0.971859117235239 5.30236555707088e-09 -2.98039017984699 5.45430675918713e-08 miRanda -1.68294189322315 8.66159008701736e-29 NA NA NA hsa-miR-429 PLA2G5 4.48815175680773 2.44117492218206e-17 -2.98039017984699 5.45430675918713e-08 miRanda -0.491944311759968 7.17164621174772e-27 NA NA NA hsa-miR-589-3p PLA2G5 2.51971841868825 2.39125940264107e-11 -2.98039017984699 5.45430675918713e-08 MirTarget -0.606412431420136 3.35739867930122e-15 NA NA NA hsa-miR-590-3p PLA2G5 2.59289455139753 1.03200520972022e-21 -2.98039017984699 5.45430675918713e-08 miRanda;miRNATAP -0.839581331965807 2.56966308437666e-19 NA NA NA hsa-miR-590-5p PLA2G5 3.18300989862077 2.06813568597893e-26 -2.98039017984699 5.45430675918713e-08 miRanda -0.832629471378237 5.18479097856289e-24 NA NA NA hsa-miR-2355-3p PLA2G6 1.2671753520641 5.70559238344897e-05 0.223163826700851 0.393344374716363 MirTarget -0.267411816628485 2.66963375924508e-11 NA NA NA hsa-miR-455-5p PLCE1 2.2582442061694 1.43472128037398e-13 -0.945170915831752 0.0418148517307417 miRanda -0.297004433910207 3.00129279872429e-05 NA NA NA hsa-miR-30a-5p PLCG1 -0.878357906436456 0.000509952992366057 0.210047767003971 0.127182592483321 miRNATAP -0.112898333505152 1.47927804909672e-05 NA NA NA hsa-miR-590-3p PLCG2 2.59289455139753 1.03200520972022e-21 -0.735903252798082 0.00875075341761775 miRanda -0.130533105835182 0.00802002106519342 NA NA NA hsa-miR-103a-3p PLD1 1.44083190496858 1.53799939616416e-13 -0.112752045973783 0.679404193461378 MirTarget -0.290749258412396 9.76391370676901e-06 NA NA NA hsa-miR-107 PLD1 1.30977326593435 1.30372468603965e-11 -0.112752045973783 0.679404193461378 MirTarget;miRanda -0.319555735017076 1.55299591377434e-06 NA NA NA hsa-miR-195-3p PLD1 -0.658653229922836 0.0142127125129199 -0.112752045973783 0.679404193461378 mirMAP -0.160813384179264 0.00127620871989443 NA NA NA hsa-miR-195-5p PLD1 -1.44753678070504 8.70594292149271e-09 -0.112752045973783 0.679404193461378 MirTarget -0.158343550992791 0.00216768760681177 NA NA NA hsa-miR-196b-5p PLD1 1.71646270856386 4.37735885910369e-09 -0.112752045973783 0.679404193461378 MirTarget -0.118127952914115 0.00772025045444381 NA NA NA hsa-miR-374a-3p PLD1 0.533309330504947 0.00192918429705142 -0.112752045973783 0.679404193461378 MirTarget -0.249047989892031 0.0012889437821255 NA NA NA hsa-miR-374b-3p PLD1 0.930487774873495 2.74420094310516e-05 -0.112752045973783 0.679404193461378 mirMAP -0.246332786987383 3.15619883301814e-05 NA NA NA hsa-miR-421 PLD1 1.17791565395543 6.78526676976629e-06 -0.112752045973783 0.679404193461378 miRanda -0.162036712244512 0.00120967542976291 NA NA NA hsa-miR-497-5p PLD1 0.0257087130056286 0.918145413833358 -0.112752045973783 0.679404193461378 MirTarget -0.216443209063946 4.04666386100875e-05 NA NA NA hsa-let-7a-3p PRKACB 1.42015538786275 7.03375209382654e-13 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.21962130459547 5.79651670137419e-05 NA NA NA hsa-let-7b-3p PRKACB 0.868207752019623 1.30460056774366e-05 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.185130585565506 0.000844018426388941 NA NA NA hsa-let-7d-3p PRKACB 0.837345596411224 1.39469480391458e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.193122206370836 0.000761987397647901 NA NA NA hsa-let-7f-1-3p PRKACB 1.55054488387679 7.31326775537952e-11 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP -0.13342047017702 0.00451064067873152 NA NA NA hsa-miR-126-5p PRKACB 0.895338176458417 2.33372756450713e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.171245788041164 0.00102349617124601 NA NA NA hsa-miR-141-3p PRKACB 5.02396127982626 2.19224509139725e-24 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 NA NA NA hsa-miR-16-2-3p PRKACB 2.31623086727196 4.29838149388188e-20 -1.11910356116881 7.24897707751757e-07 mirMAP -0.211513116774948 3.56654687944943e-07 NA NA NA hsa-miR-17-5p PRKACB 3.2710598467455 9.93128340539455e-27 -1.11910356116881 7.24897707751757e-07 TargetScan -0.195594044734934 5.04690942157379e-09 NA NA NA hsa-miR-182-5p PRKACB 3.53923166221814 5.07781258121574e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.141282769334308 3.27226662914892e-07 NA NA NA hsa-miR-183-5p PRKACB 4.19757025992371 4.79612296318304e-26 -1.11910356116881 7.24897707751757e-07 MirTarget -0.132170429294976 3.08274590025093e-07 NA NA NA hsa-miR-18a-5p PRKACB 3.78535678765353 3.72446596213886e-26 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.170312158994311 1.8268780409686e-08 NA NA NA hsa-miR-193a-3p PRKACB 1.60460546928078 2.86169793322984e-07 -1.11910356116881 7.24897707751757e-07 miRanda -0.185097829574766 8.14913568795542e-08 NA NA NA hsa-miR-19a-3p PRKACB 3.42309334186656 3.02671914353412e-28 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.217127685863828 2.72225260525319e-11 NA NA NA hsa-miR-19b-3p PRKACB 2.49529833021187 1.57028265846699e-23 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.267352556269149 9.00420806048956e-11 NA NA NA hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 NA NA NA hsa-miR-2110 PRKACB 1.16625590651194 6.4784195289885e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.106141262528439 0.00882154187258127 NA NA NA hsa-miR-3065-5p PRKACB 2.74629919868982 1.86846589298284e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.103807774563958 0.000132862723321062 NA NA NA hsa-miR-30d-3p PRKACB 0.977747550180601 4.3048212205381e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.230639716646997 4.57613056559806e-07 NA NA NA hsa-miR-32-3p PRKACB 2.02436999565685 5.94091197945307e-09 -1.11910356116881 7.24897707751757e-07 mirMAP;miRNATAP -0.100714992594509 0.00471640544853458 NA NA NA hsa-miR-339-5p PRKACB 2.68710938429893 3.03134080808154e-16 -1.11910356116881 7.24897707751757e-07 miRanda -0.145165623596419 6.50854523117634e-06 NA NA NA hsa-miR-34a-5p PRKACB 1.9016323452565 1.43092834643601e-14 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.238915288481547 2.59419071561778e-08 NA NA NA hsa-miR-361-5p PRKACB 0.971859117235239 5.30236555707088e-09 -1.11910356116881 7.24897707751757e-07 miRanda -0.178114095699739 0.00724869450353386 NA NA NA hsa-miR-362-3p PRKACB 2.0756816987665 3.89026064579331e-12 -1.11910356116881 7.24897707751757e-07 PITA;miRanda;miRNATAP -0.2320492729467 2.29661541166603e-10 NA NA NA hsa-miR-362-5p PRKACB 1.59303749908759 9.582675908797e-08 -1.11910356116881 7.24897707751757e-07 PITA -0.194987590184185 6.59081906609811e-08 NA NA NA hsa-miR-3653-3p PRKACB 1.85886928622326 2.98407490336841e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.105612181380441 0.00210192398606289 NA NA NA hsa-miR-532-5p PRKACB 1.55697650978597 1.57884735535196e-11 -1.11910356116881 7.24897707751757e-07 PITA -0.27784223940084 1.83614058183971e-09 NA NA NA hsa-miR-590-3p PRKACB 2.59289455139753 1.03200520972022e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.20137371596257 3.58630956215221e-07 NA NA NA hsa-miR-590-5p PRKACB 3.18300989862077 2.06813568597893e-26 -1.11910356116881 7.24897707751757e-07 miRanda -0.22361088291547 1.69108646897883e-10 NA NA NA hsa-miR-7-1-3p PRKACB 1.84950311431067 1.25300363397654e-13 -1.11910356116881 7.24897707751757e-07 mirMAP -0.160819398581311 0.000186176032630634 NA NA NA hsa-miR-708-3p PRKACB 2.80907765282502 3.07460722669281e-14 -1.11910356116881 7.24897707751757e-07 mirMAP -0.107628106192083 0.000190951072862047 NA NA NA hsa-miR-93-5p PRKACB 3.03961860136032 1.11672209617395e-24 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate -0.194608106414379 2.15593790853491e-08 NA NA NA hsa-miR-96-5p PRKACB 4.89433085814374 1.92000659886961e-31 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.144257226112366 5.04306410867738e-09 NA NA NA hsa-miR-142-5p PRKCA 1.17581605694506 0.0018174701991234 -1.04253532292201 0.000330447904822586 mirMAP -0.155281859758494 2.83714874751982e-05 NA NA NA hsa-miR-146a-5p PRKCA 1.19829319599115 0.00157081974524452 -1.04253532292201 0.000330447904822586 mirMAP -0.131710886401928 0.000370553312736514 NA NA NA hsa-miR-146b-5p PRKCA 1.75587235896724 1.15724631266659e-07 -1.04253532292201 0.000330447904822586 mirMAP -0.178218054737334 2.01234944480139e-05 NA NA NA hsa-miR-150-5p PRKCA -0.105827294491332 0.799351458244375 -1.04253532292201 0.000330447904822586 mirMAP -0.124697814540873 0.00022848052592286 NA NA NA hsa-miR-17-3p PRKCA 2.2704817679209 1.1667437320211e-22 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.163389027302081 0.00492702694664717 NA NA NA hsa-miR-181a-5p PRKCA 2.29556023480783 1.8138457900616e-21 -1.04253532292201 0.000330447904822586 mirMAP -0.332076264197257 1.58885695452918e-09 NA NA NA hsa-miR-181b-5p PRKCA 2.49307679431293 3.92829250217627e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.255352495229191 2.20407502467148e-07 NA NA NA hsa-miR-181c-5p PRKCA 1.58587920618301 1.57506918816933e-10 -1.04253532292201 0.000330447904822586 mirMAP -0.187181736198993 0.000814130560426752 NA NA NA hsa-miR-183-5p PRKCA 4.19757025992371 4.79612296318304e-26 -1.04253532292201 0.000330447904822586 miRNATAP -0.167765439348368 3.7027196892035e-07 NA NA NA hsa-miR-186-5p PRKCA 1.47445398888668 3.0781726595413e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.372737117584225 3.41129073481267e-07 NA NA NA hsa-miR-193b-3p PRKCA 2.25711804611899 4.1940744806631e-14 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.184015097403191 5.6276271806172e-05 NA NA NA hsa-miR-193b-5p PRKCA 1.59567208918739 4.89398272459427e-08 -1.04253532292201 0.000330447904822586 mirMAP -0.144499830970602 0.00240910945358069 NA NA NA hsa-miR-1976 PRKCA 2.06550563678192 7.81396978619772e-18 -1.04253532292201 0.000330447904822586 miRNATAP -0.17995688234711 0.00150164194068263 NA NA NA hsa-miR-19b-1-5p PRKCA 2.57951428759379 4.31576118703427e-20 -1.04253532292201 0.000330447904822586 mirMAP -0.172921934994649 0.000451924002079924 NA NA NA hsa-miR-200b-3p PRKCA 3.78235093249346 3.18343003239465e-14 -1.04253532292201 0.000330447904822586 TargetScan -0.114961109829389 2.45352651543255e-05 NA NA NA hsa-miR-200c-3p PRKCA 3.50132673580082 2.42716349086937e-15 -1.04253532292201 0.000330447904822586 miRNATAP -0.158977004957444 1.80034178057763e-07 NA NA NA hsa-miR-214-3p PRKCA -0.176344800034733 0.642485503428886 -1.04253532292201 0.000330447904822586 mirMAP -0.126245731078837 0.000711043186976772 NA NA NA hsa-miR-22-5p PRKCA 1.88011544159252 1.63978222572222e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.258621101167742 1.45994385651039e-05 NA NA NA hsa-miR-24-2-5p PRKCA 2.07171035460647 3.15853539996136e-16 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.190869345201713 0.000384051796932142 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-339-5p PRKCA 2.68710938429893 3.03134080808154e-16 -1.04253532292201 0.000330447904822586 mirMAP -0.146901538113986 0.000377758588526939 NA NA NA hsa-miR-3607-3p PRKCA 2.68532138541128 5.66716351955047e-14 -1.04253532292201 0.000330447904822586 mirMAP -0.141547181715678 0.000312501141538225 NA NA NA hsa-miR-362-5p PRKCA 1.59303749908759 9.582675908797e-08 -1.04253532292201 0.000330447904822586 TargetScan;miRNATAP -0.155938176693359 0.000821123203239911 NA NA NA hsa-miR-369-3p PRKCA 0.946781510019564 0.00134850306966842 -1.04253532292201 0.000330447904822586 PITA;miRNATAP -0.153415665611504 0.0013232753592926 NA NA NA hsa-miR-381-3p PRKCA -0.0821432056113931 0.752465205603634 -1.04253532292201 0.000330447904822586 mirMAP -0.182718955463403 0.000792478176257635 NA NA NA hsa-miR-429 PRKCA 4.48815175680773 2.44117492218206e-17 -1.04253532292201 0.000330447904822586 miRanda;miRNATAP -0.108496235247986 1.950717922572e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.69244418548325 1.68064054148881e-10 -1.04253532292201 0.000330447904822586 PITA;mirMAP;miRNATAP -0.164559118659435 0.00164963824183995 NA NA NA hsa-miR-500a-5p PRKCA 1.72110365584658 3.0807246212659e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.224298470556856 8.73025451195054e-06 NA NA NA hsa-miR-501-5p PRKCA 1.93654809410041 1.3779381780759e-10 -1.04253532292201 0.000330447904822586 miRNATAP -0.160491119587112 0.000665161220237392 NA NA NA hsa-miR-505-3p PRKCA 1.45322244209148 8.86597629645867e-10 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.17319300539973 0.00317185860747904 NA NA NA hsa-miR-505-5p PRKCA 1.89243395287645 9.82003586561819e-12 -1.04253532292201 0.000330447904822586 mirMAP -0.170760296141889 0.000583545058780229 NA NA NA hsa-miR-532-3p PRKCA 1.96631878320218 4.53421954361695e-13 -1.04253532292201 0.000330447904822586 mirMAP;miRNATAP -0.153994961004655 0.00236643084778704 NA NA NA hsa-miR-590-3p PRKCA 2.59289455139753 1.03200520972022e-21 -1.04253532292201 0.000330447904822586 PITA;miRanda;mirMAP;miRNATAP -0.257692443896068 3.43649017566933e-07 NA NA NA hsa-miR-92a-3p PRKCA 2.06460102658973 1.44784291084757e-19 -1.04253532292201 0.000330447904822586 miRNAWalker2_validate -0.177264968474978 0.0028853007950597 NA NA NA hsa-miR-93-3p PRKCA 2.85383869771942 5.64481766902125e-23 -1.04253532292201 0.000330447904822586 mirMAP -0.164593044407034 0.000371570157401047 NA NA NA hsa-miR-129-5p PRKCB -0.524170159980738 0.222582956006346 -3.26032077132529 1.38524824909011e-12 miRanda;mirMAP -0.174875281711081 0.00126377112961492 NA NA NA hsa-miR-141-5p PRKCB 3.81419396518882 3.21977359736126e-18 -3.26032077132529 1.38524824909011e-12 mirMAP -0.448157631252767 6.03056466923945e-21 NA NA NA hsa-miR-16-2-3p PRKCB 2.31623086727196 4.29838149388188e-20 -3.26032077132529 1.38524824909011e-12 mirMAP -0.508156111029493 2.858696818642e-09 NA NA NA hsa-miR-186-5p PRKCB 1.47445398888668 3.0781726595413e-15 -3.26032077132529 1.38524824909011e-12 mirMAP -0.79180135498475 1.36020814670637e-11 NA NA NA hsa-miR-194-5p PRKCB 1.8992998339217 3.76507853301977e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.485081827287577 2.16525492854143e-11 NA NA NA hsa-miR-200b-3p PRKCB 3.78235093249346 3.18343003239465e-14 -3.26032077132529 1.38524824909011e-12 MirTarget -0.450279840251611 3.58923445938153e-27 NA NA NA hsa-miR-200c-3p PRKCB 3.50132673580082 2.42716349086937e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.48715771688849 5.01263551249731e-25 NA NA NA hsa-miR-23a-3p PRKCB 1.00493340843378 2.55313889288924e-08 -3.26032077132529 1.38524824909011e-12 mirMAP -0.422834753714352 0.000810959402297788 NA NA NA hsa-miR-24-3p PRKCB 0.99989036772428 1.35595013650376e-07 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.496540154032259 3.34685620532722e-05 NA NA NA hsa-miR-26b-5p PRKCB 0.885393662798425 3.2116297961629e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.316938073060502 0.0085744560045255 NA NA NA hsa-miR-29b-2-5p PRKCB 0.910668640983475 0.00666655585493488 -3.26032077132529 1.38524824909011e-12 mirMAP -0.34510237827648 3.08410596869229e-07 NA NA NA hsa-miR-30b-5p PRKCB 0.800822374912712 0.000133601914525413 -3.26032077132529 1.38524824909011e-12 mirMAP -0.425134820547528 9.53655468608799e-05 NA NA NA hsa-miR-30c-5p PRKCB 0.778774633108 0.000285599212429136 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468954366973799 1.00031056614682e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.977747550180601 4.3048212205381e-05 -3.26032077132529 1.38524824909011e-12 mirMAP -0.529262539307465 2.03079793114812e-08 NA NA NA hsa-miR-30d-5p PRKCB 0.675423997639582 0.00270618816039773 -3.26032077132529 1.38524824909011e-12 mirMAP -0.603674275615055 1.78624617709124e-09 NA NA NA hsa-miR-330-5p PRKCB 1.15100069700871 4.85551805046014e-07 -3.26032077132529 1.38524824909011e-12 miRanda -0.265696306996962 0.00757029049385514 NA NA NA hsa-miR-335-3p PRKCB 3.08791651139852 5.31309869723517e-12 -3.26032077132529 1.38524824909011e-12 mirMAP -0.330098295724148 1.15037296640229e-11 NA NA NA hsa-miR-335-5p PRKCB 1.77247705492746 2.22457658872091e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.231797522536577 0.000116559468268159 NA NA NA hsa-miR-3607-3p PRKCB 2.68532138541128 5.66716351955047e-14 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.309871089079837 9.51108883796167e-07 NA NA NA hsa-miR-361-5p PRKCB 0.971859117235239 5.30236555707088e-09 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -1.08630383105364 2.58179254217249e-16 NA NA NA hsa-miR-429 PRKCB 4.48815175680773 2.44117492218206e-17 -3.26032077132529 1.38524824909011e-12 MirTarget;miRanda;miRNATAP -0.42521096062837 6.46582126393278e-28 NA NA NA hsa-miR-450b-5p PRKCB 1.69244418548325 1.68064054148881e-10 -3.26032077132529 1.38524824909011e-12 miRNATAP -0.300053601902219 0.00039020696289519 NA NA NA hsa-miR-452-3p PRKCB 2.42521958420768 4.08754552781156e-07 -3.26032077132529 1.38524824909011e-12 mirMAP -0.174939955360914 0.000207028768427815 NA NA NA hsa-miR-484 PRKCB 1.81844463411787 1.82951571230938e-15 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.703163397284051 1.07982697132474e-13 NA NA NA hsa-miR-491-5p PRKCB 0.615770352820862 0.0418295628761654 -3.26032077132529 1.38524824909011e-12 miRanda -0.381404660757775 2.20068611106109e-06 NA NA NA hsa-miR-589-3p PRKCB 2.51971841868825 2.39125940264107e-11 -3.26032077132529 1.38524824909011e-12 mirMAP -0.452218517865859 7.06052991667871e-12 NA NA NA hsa-miR-589-5p PRKCB 1.71990116752371 8.310889042056e-14 -3.26032077132529 1.38524824909011e-12 mirMAP -0.544486942502154 1.22125132593852e-08 NA NA NA hsa-miR-590-3p PRKCB 2.59289455139753 1.03200520972022e-21 -3.26032077132529 1.38524824909011e-12 mirMAP -0.388404821887359 2.22817064825303e-06 NA NA NA hsa-miR-590-5p PRKCB 3.18300989862077 2.06813568597893e-26 -3.26032077132529 1.38524824909011e-12 miRanda -0.553979313426607 1.10231423603006e-14 NA NA NA hsa-miR-7-1-3p PRKCB 1.84950311431067 1.25300363397654e-13 -3.26032077132529 1.38524824909011e-12 mirMAP -0.468511892026853 1.14425525890782e-07 NA NA NA hsa-miR-7-5p PRKCB 2.28980165299999 1.5131097560452e-07 -3.26032077132529 1.38524824909011e-12 MirTarget;miRNATAP -0.171892302839442 0.00201428643670522 NA NA NA hsa-miR-944 PRKCB 2.91186649218281 1.31574753528144e-06 -3.26032077132529 1.38524824909011e-12 mirMAP -0.173419280691746 6.46731956750453e-06 NA NA NA hsa-miR-181a-5p PTPN11 2.29556023480783 1.8138457900616e-21 -0.452433350411265 0.00325956478076793 miRNAWalker2_validate;miRTarBase -0.185487084256816 1.39341679605697e-10 NA NA NA hsa-miR-186-5p PTPN11 1.47445398888668 3.0781726595413e-15 -0.452433350411265 0.00325956478076793 mirMAP -0.143929471124778 0.000206640326809661 NA NA NA hsa-miR-19b-3p PTPN11 2.49529833021187 1.57028265846699e-23 -0.452433350411265 0.00325956478076793 mirMAP -0.133832285409827 1.87038395237857e-06 NA NA NA hsa-miR-30d-3p PTPN11 0.977747550180601 4.3048212205381e-05 -0.452433350411265 0.00325956478076793 mirMAP -0.101814565598371 0.0010416662764693 NA NA NA hsa-miR-660-5p PTPN11 1.82692095272076 1.92040083607196e-13 -0.452433350411265 0.00325956478076793 mirMAP -0.150622441103972 1.85298087787683e-07 NA NA NA hsa-miR-130a-3p RAB5B 2.02021855058359 1.26427102520415e-11 -0.209939771329246 0.0924519859788909 miRNATAP -0.155014756969291 3.56339243536105e-16 NA NA NA hsa-miR-19a-3p RAB5B 3.42309334186656 3.02671914353412e-28 -0.209939771329246 0.0924519859788909 miRNATAP -0.10731385752253 1.61424565047509e-09 NA NA NA hsa-miR-19b-3p RAB5B 2.49529833021187 1.57028265846699e-23 -0.209939771329246 0.0924519859788909 miRNAWalker2_validate;miRNATAP -0.124632456408565 3.26883395871539e-08 NA NA NA hsa-miR-361-3p RAB5B 1.07367425434318 1.73142774168958e-09 -0.209939771329246 0.0924519859788909 miRNATAP -0.183562480564268 2.76861545079594e-08 NA NA NA hsa-miR-628-5p RAB5B 0.799263053510813 2.28892357418044e-05 -0.209939771329246 0.0924519859788909 miRNATAP -0.110777235791825 0.000512519467784569 NA NA NA hsa-miR-374b-5p RAC1 0.0654362503857184 0.722673188879465 0.221936454340431 0.051549220692643 mirMAP -0.101573831955509 0.000746852128506454 NA NA NA hsa-miR-375 RAC2 1.13910305294079 0.0512283522214186 0.0225400305534329 0.947191555182511 miRanda -0.111974015284125 5.98476138848745e-05 NA NA NA hsa-miR-139-5p RALA -1.52606598644743 1.20474151350665e-08 0.464178347432774 0.000203543564643978 miRanda -0.10651772247956 1.44235906464586e-06 NA NA NA hsa-miR-29c-3p RALA -0.00968972577705429 0.97099586346872 0.464178347432774 0.000203543564643978 miRNATAP -0.163115570479502 2.2252137670795e-13 NA NA NA hsa-miR-30e-3p RALA -0.215663037684509 0.235375122783546 0.464178347432774 0.000203543564643978 MirTarget;miRNATAP -0.149158997749012 8.84627920861925e-06 NA NA NA hsa-let-7d-5p RALB 1.33236798905207 1.1741085658466e-13 -0.226951263019001 0.126583512825785 MirTarget;miRNATAP -0.151916157510647 9.95158043111843e-05 NA NA NA hsa-let-7f-5p RALB 0.495648727272215 0.00355972741198794 -0.226951263019001 0.126583512825785 MirTarget;miRNATAP -0.136741938757296 0.00132706520887042 NA NA NA hsa-let-7g-5p RALB 1.20061455355116 1.50237505511483e-12 -0.226951263019001 0.126583512825785 MirTarget;miRNATAP -0.243791104248997 2.80789654922496e-09 NA NA NA hsa-miR-28-5p RALB 0.230152919654905 0.0742909586754846 -0.226951263019001 0.126583512825785 miRanda -0.193758468195216 0.000709351511887023 NA NA NA hsa-miR-30b-3p RALB 0.834142820354026 0.000972582820878813 -0.226951263019001 0.126583512825785 MirTarget -0.135760818435697 1.48044177241814e-06 NA NA NA hsa-miR-30d-3p RALB 0.977747550180601 4.3048212205381e-05 -0.226951263019001 0.126583512825785 MirTarget -0.153949359263302 1.96347459680721e-07 NA NA NA hsa-miR-30e-3p RALB -0.215663037684509 0.235375122783546 -0.226951263019001 0.126583512825785 MirTarget -0.253470172075886 9.95133416362897e-11 NA NA NA hsa-miR-330-3p RALB 0.876747334239085 0.00073709016089703 -0.226951263019001 0.126583512825785 mirMAP -0.113176148088836 3.61937108921078e-05 NA NA NA hsa-miR-374a-5p RALB 0.484615721953736 0.0042981729815149 -0.226951263019001 0.126583512825785 mirMAP -0.185110613351366 1.31182028378502e-05 NA NA NA hsa-miR-664a-5p RALB 0.505019913598436 0.032933350691651 -0.226951263019001 0.126583512825785 MirTarget -0.162961735851214 6.35984090639713e-08 NA NA NA hsa-miR-98-5p RALB 1.11154309866014 1.24143909012085e-08 -0.226951263019001 0.126583512825785 MirTarget -0.238964430109714 2.07710979849262e-11 NA NA NA hsa-miR-135b-5p RALBP1 3.62510365056501 1.09148980810091e-10 0.406788131900375 0.126272070955269 MirTarget -0.145897738406072 3.52096577209254e-10 NA NA NA hsa-miR-217 RALBP1 0.608024397387488 0.199352491710517 0.406788131900375 0.126272070955269 PITA;miRanda -0.113030093250863 4.64500952576653e-05 NA NA NA hsa-miR-29a-5p RALBP1 1.46749674755271 3.34605004270294e-07 0.406788131900375 0.126272070955269 MirTarget;miRNATAP -0.152379489454174 0.00110811101629667 NA NA NA hsa-let-7a-3p RAP1A 1.42015538786275 7.03375209382654e-13 -1.0434884652411 1.94863584356979e-14 mirMAP -0.224724794924004 8.95540940127091e-12 NA NA NA hsa-let-7b-3p RAP1A 0.868207752019623 1.30460056774366e-05 -1.0434884652411 1.94863584356979e-14 mirMAP -0.101197716480348 0.0029967877921152 NA NA NA hsa-miR-101-5p RAP1A 0.782067874775122 0.00443725251526842 -1.0434884652411 1.94863584356979e-14 MirTarget -0.13103442258546 1.91947268044239e-07 NA NA NA hsa-miR-125a-5p RAP1A 0.599529391575274 0.0102300147180307 -1.0434884652411 1.94863584356979e-14 miRanda -0.120822313738346 3.16483745923974e-05 NA NA NA hsa-miR-149-5p RAP1A 2.94200492826326 4.93436498919036e-14 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.106140260829361 1.27806775160534e-10 NA NA NA hsa-miR-16-1-3p RAP1A 2.56983217111073 3.02262181237943e-20 -1.0434884652411 1.94863584356979e-14 MirTarget -0.196961148602664 1.22905853869133e-17 NA NA NA hsa-miR-16-2-3p RAP1A 2.31623086727196 4.29838149388188e-20 -1.0434884652411 1.94863584356979e-14 MirTarget;mirMAP -0.173549845840885 5.56374526112486e-12 NA NA NA hsa-miR-186-5p RAP1A 1.47445398888668 3.0781726595413e-15 -1.0434884652411 1.94863584356979e-14 mirMAP -0.204598710416168 4.80532165007133e-09 NA NA NA hsa-miR-19a-3p RAP1A 3.42309334186656 3.02671914353412e-28 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.16815717960042 1.30227368899674e-17 NA NA NA hsa-miR-19b-3p RAP1A 2.49529833021187 1.57028265846699e-23 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.215451937444313 4.11793601184036e-18 NA NA NA hsa-miR-25-3p RAP1A 1.36472605225697 4.83790725935681e-11 -1.0434884652411 1.94863584356979e-14 mirMAP -0.230057213097495 2.26977159326414e-13 NA NA NA hsa-miR-26a-2-3p RAP1A 0.823520019989974 0.00017092160823769 -1.0434884652411 1.94863584356979e-14 MirTarget -0.138689266178359 7.61798152695236e-06 NA NA NA hsa-miR-26b-5p RAP1A 0.885393662798425 3.2116297961629e-06 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.163040362705406 4.24517403285822e-06 NA NA NA hsa-miR-32-5p RAP1A 2.34056473219422 6.24134585974322e-20 -1.0434884652411 1.94863584356979e-14 mirMAP;miRNATAP -0.190660947454226 1.01725447373065e-14 NA NA NA hsa-miR-320a RAP1A 0.438165828017084 0.0390159073347133 -1.0434884652411 1.94863584356979e-14 MirTarget;PITA;miRanda;miRNATAP -0.21602759664377 6.95103599006302e-12 NA NA NA hsa-miR-320b RAP1A 1.55692969039548 1.41071034251915e-08 -1.0434884652411 1.94863584356979e-14 MirTarget;PITA;miRanda;miRNATAP -0.16423312802573 5.48401921536116e-12 NA NA NA hsa-miR-324-5p RAP1A 2.95683728155095 1.32960514360912e-20 -1.0434884652411 1.94863584356979e-14 miRanda -0.153641776425352 7.54744772252417e-15 NA NA NA hsa-miR-362-3p RAP1A 2.0756816987665 3.89026064579331e-12 -1.0434884652411 1.94863584356979e-14 miRanda -0.11220810269389 7.49219849039476e-07 NA NA NA hsa-miR-3913-5p RAP1A 2.44353493655328 8.95279496632448e-15 -1.0434884652411 1.94863584356979e-14 mirMAP -0.191495114855697 1.03372355391545e-20 NA NA NA hsa-miR-429 RAP1A 4.48815175680773 2.44117492218206e-17 -1.0434884652411 1.94863584356979e-14 miRanda -0.119129230968671 1.02711682003224e-24 NA NA NA hsa-miR-501-3p RAP1A 1.83132758513743 1.10971547702065e-10 -1.0434884652411 1.94863584356979e-14 TargetScan;miRNATAP -0.113815693051489 9.49341834246497e-07 NA NA NA hsa-miR-590-3p RAP1A 2.59289455139753 1.03200520972022e-21 -1.0434884652411 1.94863584356979e-14 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.141676976493134 4.57436054034706e-09 NA NA NA hsa-miR-590-5p RAP1A 3.18300989862077 2.06813568597893e-26 -1.0434884652411 1.94863584356979e-14 miRanda -0.15348101987022 6.65517116991475e-13 NA NA NA hsa-miR-625-3p RAP1A 1.18769734290812 2.47200238827911e-06 -1.0434884652411 1.94863584356979e-14 mirMAP -0.112213454103308 2.43830810284901e-05 NA NA NA hsa-miR-660-5p RAP1A 1.82692095272076 1.92040083607196e-13 -1.0434884652411 1.94863584356979e-14 MirTarget;miRNATAP -0.170753703159053 6.16218370126605e-11 NA NA NA hsa-miR-664a-3p RAP1A 0.634721925861133 0.00520070178640421 -1.0434884652411 1.94863584356979e-14 mirMAP -0.189816392665286 1.09988671069259e-10 NA NA NA hsa-miR-7-1-3p RAP1A 1.84950311431067 1.25300363397654e-13 -1.0434884652411 1.94863584356979e-14 mirMAP -0.149042260688725 1.17362806253114e-08 NA NA NA hsa-miR-877-5p RAP1A 2.94916202082736 1.8151927276044e-13 -1.0434884652411 1.94863584356979e-14 mirMAP -0.111721180135264 8.82048176615582e-10 NA NA NA hsa-miR-92a-3p RAP1A 2.06460102658973 1.44784291084757e-19 -1.0434884652411 1.94863584356979e-14 mirMAP;miRNATAP -0.223541569866338 6.32044230210158e-16 NA NA NA hsa-miR-107 RAPGEF5 1.30977326593435 1.30372468603965e-11 -0.580986175597244 0.0366906480299328 miRanda -0.196467037452674 0.00416663217844782 NA NA NA hsa-miR-125a-3p RAPGEF5 1.24490295132072 5.26925231010328e-06 -0.580986175597244 0.0366906480299328 miRanda -0.145773926081112 0.00288339612270855 NA NA NA hsa-miR-125a-5p RAPGEF5 0.599529391575274 0.0102300147180307 -0.580986175597244 0.0366906480299328 MirTarget;PITA;miRanda -0.378402896092275 2.42015984659798e-11 NA NA NA hsa-miR-141-3p RAPGEF5 5.02396127982626 2.19224509139725e-24 -0.580986175597244 0.0366906480299328 MirTarget -0.141329721270982 2.51336087847175e-08 NA NA NA hsa-miR-17-5p RAPGEF5 3.2710598467455 9.93128340539455e-27 -0.580986175597244 0.0366906480299328 TargetScan -0.110169756647286 0.0077694936270518 NA NA NA hsa-miR-182-5p RAPGEF5 3.53923166221814 5.07781258121574e-21 -0.580986175597244 0.0366906480299328 MirTarget -0.164378855734397 1.09181602237902e-06 NA NA NA hsa-miR-186-5p RAPGEF5 1.47445398888668 3.0781726595413e-15 -0.580986175597244 0.0366906480299328 mirMAP -0.222471997592309 0.001553937792706 NA NA NA hsa-miR-19a-3p RAPGEF5 3.42309334186656 3.02671914353412e-28 -0.580986175597244 0.0366906480299328 mirMAP -0.117798272889086 0.00365446144525396 NA NA NA hsa-miR-19b-3p RAPGEF5 2.49529833021187 1.57028265846699e-23 -0.580986175597244 0.0366906480299328 mirMAP -0.185097214482556 0.000289069258142853 NA NA NA hsa-miR-200a-3p RAPGEF5 4.59434485520731 6.38952518573476e-18 -0.580986175597244 0.0366906480299328 MirTarget -0.136083691339533 1.14244112815273e-08 NA NA NA hsa-miR-3127-5p RAPGEF5 1.51846438737133 3.59571251672767e-07 -0.580986175597244 0.0366906480299328 MirTarget -0.169616310079809 0.000134569839121196 NA NA NA hsa-miR-3200-3p RAPGEF5 2.70510522077868 1.90469509928484e-08 -0.580986175597244 0.0366906480299328 MirTarget -0.118484372928901 4.52094365847088e-05 NA NA NA hsa-miR-320a RAPGEF5 0.438165828017084 0.0390159073347133 -0.580986175597244 0.0366906480299328 miRanda;mirMAP -0.231653957591207 0.000276766787242823 NA NA NA hsa-miR-330-3p RAPGEF5 0.876747334239085 0.00073709016089703 -0.580986175597244 0.0366906480299328 mirMAP -0.244651068831859 1.87833023301043e-06 NA NA NA hsa-miR-335-3p RAPGEF5 3.08791651139852 5.31309869723517e-12 -0.580986175597244 0.0366906480299328 mirMAP -0.126140240578397 1.41918009002265e-05 NA NA NA hsa-miR-576-5p RAPGEF5 2.20467023993664 3.4053475193793e-19 -0.580986175597244 0.0366906480299328 MirTarget;PITA -0.152876308017963 0.00360144304025881 NA NA NA hsa-miR-664a-3p RAPGEF5 0.634721925861133 0.00520070178640421 -0.580986175597244 0.0366906480299328 mirMAP -0.391387605096987 1.77574210783916e-11 NA NA NA hsa-miR-664a-5p RAPGEF5 0.505019913598436 0.032933350691651 -0.580986175597244 0.0366906480299328 mirMAP -0.261880700651926 4.18474566560556e-06 NA NA NA hsa-miR-940 RAPGEF5 3.21011374578759 2.7923171128495e-14 -0.580986175597244 0.0366906480299328 MirTarget -0.101710064087882 0.00253848595714868 NA NA NA hsa-miR-30c-5p RASA1 0.778774633108 0.000285599212429136 -0.0207024925540615 0.910533635152395 miRNAWalker2_validate;MirTarget;miRNATAP -0.14388971632777 0.000504818574153645 NA NA NA hsa-miR-320a RASA1 0.438165828017084 0.0390159073347133 -0.0207024925540615 0.910533635152395 MirTarget;PITA;miRanda;miRNATAP -0.156593432428182 0.000194139100509342 NA NA NA hsa-miR-1301-3p RASA3 2.54959518791507 5.26618591274892e-18 -1.49754552147671 5.69227000838479e-06 MirTarget -0.400093264714012 4.1702303683376e-15 NA NA NA hsa-miR-186-5p RASA3 1.47445398888668 3.0781726595413e-15 -1.49754552147671 5.69227000838479e-06 miRNATAP -0.622025804790809 3.19087830218464e-14 NA NA NA hsa-miR-335-5p RASA3 1.77247705492746 2.22457658872091e-06 -1.49754552147671 5.69227000838479e-06 miRNAWalker2_validate -0.201034196521617 1.89668067447057e-06 NA NA NA hsa-miR-421 RASA3 1.17791565395543 6.78526676976629e-06 -1.49754552147671 5.69227000838479e-06 miRanda -0.414774590610363 4.71325167608683e-12 NA NA NA hsa-miR-450b-5p RASA3 1.69244418548325 1.68064054148881e-10 -1.49754552147671 5.69227000838479e-06 mirMAP -0.221499081253184 0.000200906982197121 NA NA NA hsa-miR-590-3p RASA3 2.59289455139753 1.03200520972022e-21 -1.49754552147671 5.69227000838479e-06 miRanda -0.382284954994595 2.14561136082096e-11 NA NA NA hsa-miR-92a-3p RASA3 2.06460102658973 1.44784291084757e-19 -1.49754552147671 5.69227000838479e-06 miRNAWalker2_validate -0.532501050881091 5.37766194663736e-16 NA NA NA hsa-miR-103a-2-5p RASA4 2.47599305985086 7.933028987326e-11 -1.1892508233376 1.32902275444348e-05 mirMAP -0.176121801447594 4.62442502946081e-06 NA NA NA hsa-miR-141-3p RASA4 5.02396127982626 2.19224509139725e-24 -1.1892508233376 1.32902275444348e-05 mirMAP -0.119498282223186 2.20769572742455e-06 NA NA NA hsa-miR-15b-5p RASA4 1.57112623124278 9.14247846750597e-13 -1.1892508233376 1.32902275444348e-05 mirMAP -0.377299676410567 8.9143959300517e-11 NA NA NA hsa-miR-16-5p RASA4 1.75824877145857 1.68592440033108e-16 -1.1892508233376 1.32902275444348e-05 mirMAP -0.268628202583912 8.19551758921584e-06 NA NA NA hsa-miR-186-5p RASA4 1.47445398888668 3.0781726595413e-15 -1.1892508233376 1.32902275444348e-05 mirMAP -0.399334560442312 6.01443900924261e-09 NA NA NA hsa-miR-19b-1-5p RASA4 2.57951428759379 4.31576118703427e-20 -1.1892508233376 1.32902275444348e-05 mirMAP -0.237145566568655 2.73635598987051e-07 NA NA NA hsa-miR-200a-3p RASA4 4.59434485520731 6.38952518573476e-18 -1.1892508233376 1.32902275444348e-05 mirMAP -0.107287223655353 6.4345637425733e-06 NA NA NA hsa-miR-2355-5p RASA4 1.32510310704724 8.25139516692683e-07 -1.1892508233376 1.32902275444348e-05 mirMAP -0.274243822667611 1.51487921240796e-08 NA NA NA hsa-miR-331-3p RASA4 2.28379581858927 1.99663919173155e-18 -1.1892508233376 1.32902275444348e-05 mirMAP -0.307064466204336 1.93715130868292e-10 NA NA NA hsa-miR-340-5p RASA4 0.30282999308409 0.157744789519131 -1.1892508233376 1.32902275444348e-05 mirMAP -0.205303108650282 0.00104791285427487 NA NA NA hsa-miR-424-5p RASA4 1.61930224569578 1.89642549274994e-10 -1.1892508233376 1.32902275444348e-05 mirMAP -0.237668979149006 3.31523650106786e-06 NA NA NA hsa-miR-491-5p RASA4 0.615770352820862 0.0418295628761654 -1.1892508233376 1.32902275444348e-05 mirMAP -0.1467333310555 0.00190687275546507 NA NA NA hsa-miR-590-3p RASA4 2.59289455139753 1.03200520972022e-21 -1.1892508233376 1.32902275444348e-05 miRanda;mirMAP -0.278643255815711 4.3322124937282e-09 NA NA NA hsa-miR-940 RASA4 3.21011374578759 2.7923171128495e-14 -1.1892508233376 1.32902275444348e-05 mirMAP -0.168211921198504 3.55622075888501e-07 NA NA NA hsa-miR-128-3p RASAL2 1.63756041666078 6.79626586407187e-14 -0.0926342056550231 0.62870415331481 MirTarget -0.135303745939743 0.00102666283559245 NA NA NA hsa-miR-151a-3p RASAL2 1.24018761527407 1.08839919675408e-07 -0.0926342056550231 0.62870415331481 MirTarget -0.107263583835739 0.00625841333957234 NA NA NA hsa-miR-186-5p RASAL2 1.47445398888668 3.0781726595413e-15 -0.0926342056550231 0.62870415331481 mirMAP -0.169252999558007 0.000443737364745585 NA NA NA hsa-miR-26b-3p RASAL2 2.18464160365372 2.11543189388328e-18 -0.0926342056550231 0.62870415331481 MirTarget -0.134567777443737 0.000149310444414856 NA NA NA hsa-miR-26b-5p RASAL2 0.885393662798425 3.2116297961629e-06 -0.0926342056550231 0.62870415331481 miRNAWalker2_validate -0.218056017914871 6.25560438789606e-06 NA NA NA hsa-miR-29b-3p RASAL2 1.65828197923813 1.02676780888141e-09 -0.0926342056550231 0.62870415331481 MirTarget -0.128518223609792 0.000114200777017871 NA NA NA hsa-miR-29c-3p RASAL2 -0.00968972577705429 0.97099586346872 -0.0926342056550231 0.62870415331481 MirTarget -0.214712898119004 3.50071435737966e-10 NA NA NA hsa-miR-30d-3p RASAL2 0.977747550180601 4.3048212205381e-05 -0.0926342056550231 0.62870415331481 mirMAP -0.113773600841176 0.00319364155591146 NA NA NA hsa-miR-30e-3p RASAL2 -0.215663037684509 0.235375122783546 -0.0926342056550231 0.62870415331481 mirMAP -0.219927129213041 1.78041124571804e-05 NA NA NA hsa-miR-3607-3p RASAL2 2.68532138541128 5.66716351955047e-14 -0.0926342056550231 0.62870415331481 mirMAP -0.120558407498629 2.34699094861322e-06 NA NA NA hsa-miR-361-5p RASAL2 0.971859117235239 5.30236555707088e-09 -0.0926342056550231 0.62870415331481 mirMAP -0.145138694927813 0.0088355136747481 NA NA NA hsa-miR-374a-3p RASAL2 0.533309330504947 0.00192918429705142 -0.0926342056550231 0.62870415331481 mirMAP -0.275633511380786 2.94748370405827e-07 NA NA NA hsa-miR-374a-5p RASAL2 0.484615721953736 0.0042981729815149 -0.0926342056550231 0.62870415331481 mirMAP -0.152694006815516 0.00563813377893918 NA NA NA hsa-miR-625-5p RASAL2 1.42540152147292 1.95797147911206e-06 -0.0926342056550231 0.62870415331481 MirTarget -0.125600062980282 0.000172667566683554 NA NA NA hsa-miR-664a-3p RASAL2 0.634721925861133 0.00520070178640421 -0.0926342056550231 0.62870415331481 mirMAP -0.293733888863391 1.43975794503873e-13 NA NA NA hsa-miR-874-3p RASAL2 1.95617235160298 2.0152613104032e-12 -0.0926342056550231 0.62870415331481 MirTarget -0.143204853219561 8.67030489786071e-06 NA NA NA hsa-miR-92a-3p RASAL2 2.06460102658973 1.44784291084757e-19 -0.0926342056550231 0.62870415331481 miRNAWalker2_validate -0.128810699908081 0.000915202382670835 NA NA NA hsa-miR-98-5p RASAL2 1.11154309866014 1.24143909012085e-08 -0.0926342056550231 0.62870415331481 miRNAWalker2_validate -0.129809364703843 0.0057728881594652 NA NA NA hsa-miR-320a RASAL3 0.438165828017084 0.0390159073347133 -0.480405729020543 0.180470735016997 miRanda -0.222412088061508 0.00693507512997988 NA NA NA hsa-miR-320b RASAL3 1.55692969039548 1.41071034251915e-08 -0.480405729020543 0.180470735016997 miRanda -0.241726232243357 9.78298557665697e-05 NA NA NA hsa-miR-324-5p RASAL3 2.95683728155095 1.32960514360912e-20 -0.480405729020543 0.180470735016997 miRanda -0.217909673003884 2.56002994556107e-05 NA NA NA hsa-miR-29b-2-5p RASGRF1 0.910668640983475 0.00666655585493488 1.27370554930097 0.01316303188544 mirMAP -0.253288449141953 0.000619811640224574 NA NA NA hsa-miR-320a RASGRF1 0.438165828017084 0.0390159073347133 1.27370554930097 0.01316303188544 miRanda -0.374514134461256 0.0015229444580916 NA NA NA hsa-let-7a-3p RASGRF2 1.42015538786275 7.03375209382654e-13 -0.959101466033611 0.00295453490406439 mirMAP -0.354340266719315 4.37397814040873e-06 NA NA NA hsa-miR-103a-2-5p RASGRF2 2.47599305985086 7.933028987326e-11 -0.959101466033611 0.00295453490406439 mirMAP -0.303701392890361 8.83465131281723e-12 NA NA NA hsa-miR-106a-5p RASGRF2 2.48882002962836 1.99757727374521e-12 -0.959101466033611 0.00295453490406439 MirTarget -0.253504555445005 2.23776501835649e-09 NA NA NA hsa-miR-106b-5p RASGRF2 2.46782146831112 1.36171495805632e-23 -0.959101466033611 0.00295453490406439 MirTarget -0.489650883516531 3.88966956864674e-17 NA NA NA hsa-miR-1266-5p RASGRF2 1.3763848124288 0.000876906064212958 -0.959101466033611 0.00295453490406439 MirTarget -0.160320352078417 2.05739533143518e-05 NA NA NA hsa-miR-129-5p RASGRF2 -0.524170159980738 0.222582956006346 -0.959101466033611 0.00295453490406439 mirMAP -0.129844885064158 0.000460642814601332 NA NA NA hsa-miR-144-3p RASGRF2 0.658119849508907 0.146943823997989 -0.959101466033611 0.00295453490406439 MirTarget -0.103815914082991 0.00353526087266036 NA NA NA hsa-miR-17-5p RASGRF2 3.2710598467455 9.93128340539455e-27 -0.959101466033611 0.00295453490406439 MirTarget;TargetScan -0.388507484141023 5.81881938546046e-17 NA NA NA hsa-miR-182-5p RASGRF2 3.53923166221814 5.07781258121574e-21 -0.959101466033611 0.00295453490406439 mirMAP -0.280032478581552 3.94983090544796e-13 NA NA NA hsa-miR-20a-5p RASGRF2 3.15577933619191 4.19753346442454e-25 -0.959101466033611 0.00295453490406439 MirTarget -0.384082682232264 2.28016569629488e-16 NA NA NA hsa-miR-20b-5p RASGRF2 2.07706563022469 1.10107236083433e-05 -0.959101466033611 0.00295453490406439 MirTarget -0.141765383171134 1.33829153900026e-05 NA NA NA hsa-miR-224-5p RASGRF2 2.94107125335675 5.72194099515157e-08 -0.959101466033611 0.00295453490406439 MirTarget -0.132472394468524 2.53083760354603e-06 NA NA NA hsa-miR-3065-5p RASGRF2 2.74629919868982 1.86846589298284e-08 -0.959101466033611 0.00295453490406439 mirMAP -0.207531450630493 5.32321107917532e-08 NA NA NA hsa-miR-30d-3p RASGRF2 0.977747550180601 4.3048212205381e-05 -0.959101466033611 0.00295453490406439 mirMAP -0.410211731840294 1.66853922844251e-10 NA NA NA hsa-miR-30e-3p RASGRF2 -0.215663037684509 0.235375122783546 -0.959101466033611 0.00295453490406439 mirMAP -0.245989417875303 0.00490846179850226 NA NA NA hsa-miR-320a RASGRF2 0.438165828017084 0.0390159073347133 -0.959101466033611 0.00295453490406439 miRNATAP -0.361437594493406 9.27311188942508e-07 NA NA NA hsa-miR-320b RASGRF2 1.55692969039548 1.41071034251915e-08 -0.959101466033611 0.00295453490406439 miRNATAP -0.383429578468431 2.99151617711296e-12 NA NA NA hsa-miR-324-5p RASGRF2 2.95683728155095 1.32960514360912e-20 -0.959101466033611 0.00295453490406439 miRNATAP -0.321261382335988 2.59014816441969e-12 NA NA NA hsa-miR-330-3p RASGRF2 0.876747334239085 0.00073709016089703 -0.959101466033611 0.00295453490406439 mirMAP -0.300392316226483 4.73745675980151e-07 NA NA NA hsa-miR-34a-3p RASGRF2 1.75590866103657 8.02801510630657e-09 -0.959101466033611 0.00295453490406439 mirMAP -0.243930495689873 1.30413895856795e-05 NA NA NA hsa-miR-421 RASGRF2 1.17791565395543 6.78526676976629e-06 -0.959101466033611 0.00295453490406439 miRanda;mirMAP -0.31493429928954 8.95779155643084e-08 NA NA NA hsa-miR-429 RASGRF2 4.48815175680773 2.44117492218206e-17 -0.959101466033611 0.00295453490406439 miRanda -0.200335097247864 3.96990043767509e-13 NA NA NA hsa-miR-491-5p RASGRF2 0.615770352820862 0.0418295628761654 -0.959101466033611 0.00295453490406439 miRanda -0.173260821253958 0.00181016260712164 NA NA NA hsa-miR-590-3p RASGRF2 2.59289455139753 1.03200520972022e-21 -0.959101466033611 0.00295453490406439 MirTarget;miRanda -0.342244796870533 7.80361504056741e-10 NA NA NA hsa-miR-590-5p RASGRF2 3.18300989862077 2.06813568597893e-26 -0.959101466033611 0.00295453490406439 miRanda -0.329198065863786 2.91399002348044e-11 NA NA NA hsa-miR-664a-3p RASGRF2 0.634721925861133 0.00520070178640421 -0.959101466033611 0.00295453490406439 mirMAP -0.246555400374732 0.000355617089927053 NA NA NA hsa-miR-93-5p RASGRF2 3.03961860136032 1.11672209617395e-24 -0.959101466033611 0.00295453490406439 MirTarget -0.403876760673153 4.83197709143151e-17 NA NA NA hsa-let-7a-5p RASGRP1 0.618599506841644 2.76973453058748e-05 0.191950588717897 0.655147955221155 MirTarget;TargetScan;miRNATAP -0.392494685914432 0.00597286583942776 NA NA NA hsa-let-7e-5p RASGRP1 0.860104282510173 6.04758298373779e-05 0.191950588717897 0.655147955221155 MirTarget;miRNATAP -0.583845569747264 8.68830027695287e-10 NA NA NA hsa-miR-30d-3p RASGRP1 0.977747550180601 4.3048212205381e-05 0.191950588717897 0.655147955221155 MirTarget -0.322587105988672 0.000191032301156401 NA NA NA hsa-miR-30e-3p RASGRP1 -0.215663037684509 0.235375122783546 0.191950588717897 0.655147955221155 MirTarget -0.302011426146603 0.00923112985675683 NA NA NA hsa-miR-320a RASGRP1 0.438165828017084 0.0390159073347133 0.191950588717897 0.655147955221155 miRanda -0.352883335036029 0.000331039020053233 NA NA NA hsa-miR-429 RASGRP1 4.48815175680773 2.44117492218206e-17 0.191950588717897 0.655147955221155 miRanda -0.156681950877704 2.73949847524052e-05 NA NA NA hsa-miR-582-5p RASGRP1 0.609226359812689 0.032988717891497 0.191950588717897 0.655147955221155 MirTarget -0.416220512178729 6.4599758610322e-09 NA NA NA hsa-miR-98-5p RASGRP1 1.11154309866014 1.24143909012085e-08 0.191950588717897 0.655147955221155 MirTarget -0.417025513810675 7.36774536256623e-05 NA NA NA hsa-miR-324-3p RASGRP2 2.08739139768981 3.11885987067952e-13 -3.16857887195918 2.09718322290424e-14 PITA -0.736048773206101 5.1111254858267e-29 NA NA NA hsa-miR-484 RASGRP2 1.81844463411787 1.82951571230938e-15 -3.16857887195918 2.09718322290424e-14 PITA -0.619332238576668 5.24531090786405e-13 NA NA NA hsa-miR-940 RASGRP2 3.21011374578759 2.7923171128495e-14 -3.16857887195918 2.09718322290424e-14 MirTarget;PITA;miRNATAP -0.521374023201122 1.22092840074636e-26 NA NA NA hsa-miR-324-3p RASGRP3 2.08739139768981 3.11885987067952e-13 -0.0443708040963782 0.850285116887387 MirTarget -0.168294979807098 1.11811257190529e-05 NA NA NA hsa-miR-28-5p RASGRP4 0.230152919654905 0.0742909586754846 -1.81932059503105 2.30066832429026e-06 miRanda -0.440690225574773 0.0034855563518016 NA NA NA hsa-miR-30b-3p RASGRP4 0.834142820354026 0.000972582820878813 -1.81932059503105 2.30066832429026e-06 MirTarget -0.65125310483836 1.05989377102438e-19 NA NA NA hsa-miR-34a-5p RASGRP4 1.9016323452565 1.43092834643601e-14 -1.81932059503105 2.30066832429026e-06 MirTarget -0.421860932834008 7.68217450355339e-09 NA NA NA hsa-miR-744-5p RASSF1 1.48254348878737 3.23019501613577e-09 -0.255772087445639 0.107838711733709 miRNAWalker2_validate -0.103430119845104 0.000599862437988885 NA NA NA hsa-miR-193b-3p RASSF5 2.25711804611899 4.1940744806631e-14 -0.459521846409834 0.057079929584638 miRNAWalker2_validate -0.107559281956556 0.00459789104354504 NA NA NA hsa-miR-339-5p RASSF5 2.68710938429893 3.03134080808154e-16 -0.459521846409834 0.057079929584638 miRanda -0.107050841152186 0.00175826341436271 NA NA NA hsa-miR-421 RASSF5 1.17791565395543 6.78526676976629e-06 -0.459521846409834 0.057079929584638 miRanda -0.240601388925521 4.19227001924012e-08 NA NA NA hsa-miR-450b-5p RASSF5 1.69244418548325 1.68064054148881e-10 -0.459521846409834 0.057079929584638 PITA -0.204968708939115 1.77651408873061e-06 NA NA NA hsa-miR-542-3p RASSF5 1.18832665895751 1.98700670691565e-07 -0.459521846409834 0.057079929584638 miRanda -0.200729563421751 7.04676072523812e-05 NA NA NA hsa-miR-217 REL 0.608024397387488 0.199352491710517 -0.37107090294153 0.295384901319937 miRanda -0.162147881881152 1.12733153320328e-05 NA NA NA hsa-miR-103a-2-5p RGL1 2.47599305985086 7.933028987326e-11 -1.51925487686695 6.14848968356696e-09 MirTarget -0.210825083823185 1.06884025905617e-08 NA NA NA hsa-miR-106a-5p RGL1 2.48882002962836 1.99757727374521e-12 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.148018139060164 2.61582240816701e-05 NA NA NA hsa-miR-106b-5p RGL1 2.46782146831112 1.36171495805632e-23 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.407516265576866 1.39981547407585e-17 NA NA NA hsa-miR-130b-5p RGL1 2.9963110846538 1.98883029416455e-18 -1.51925487686695 6.14848968356696e-09 mirMAP -0.251280517155286 3.80844590201875e-12 NA NA NA hsa-miR-135b-5p RGL1 3.62510365056501 1.09148980810091e-10 -1.51925487686695 6.14848968356696e-09 MirTarget -0.112679003337253 1.61874505421344e-06 NA NA NA hsa-miR-16-2-3p RGL1 2.31623086727196 4.29838149388188e-20 -1.51925487686695 6.14848968356696e-09 mirMAP -0.27599361788085 1.00237115655749e-08 NA NA NA hsa-miR-17-5p RGL1 3.2710598467455 9.93128340539455e-27 -1.51925487686695 6.14848968356696e-09 MirTarget;TargetScan;miRNATAP -0.329111005457395 5.03092712952396e-18 NA NA NA hsa-miR-182-5p RGL1 3.53923166221814 5.07781258121574e-21 -1.51925487686695 6.14848968356696e-09 MirTarget -0.280987384646267 2.05586290564071e-19 NA NA NA hsa-miR-19a-3p RGL1 3.42309334186656 3.02671914353412e-28 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.284566292755825 4.16044639232033e-14 NA NA NA hsa-miR-19b-3p RGL1 2.49529833021187 1.57028265846699e-23 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.385816374885393 3.56362833376024e-16 NA NA NA hsa-miR-200b-3p RGL1 3.78235093249346 3.18343003239465e-14 -1.51925487686695 6.14848968356696e-09 MirTarget;TargetScan -0.237410974259999 1.0674707539047e-23 NA NA NA hsa-miR-200c-3p RGL1 3.50132673580082 2.42716349086937e-15 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.267570265729395 7.95898817127779e-24 NA NA NA hsa-miR-20a-5p RGL1 3.15577933619191 4.19753346442454e-25 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.325905148377058 1.9101501514968e-17 NA NA NA hsa-miR-25-3p RGL1 1.36472605225697 4.83790725935681e-11 -1.51925487686695 6.14848968356696e-09 MirTarget -0.333551234106579 3.1741723413413e-08 NA NA NA hsa-miR-30c-5p RGL1 0.778774633108 0.000285599212429136 -1.51925487686695 6.14848968356696e-09 miRNATAP -0.25665346694151 1.72584549294282e-05 NA NA NA hsa-miR-30d-5p RGL1 0.675423997639582 0.00270618816039773 -1.51925487686695 6.14848968356696e-09 miRNATAP -0.175006315495754 0.00225879116277726 NA NA NA hsa-miR-32-5p RGL1 2.34056473219422 6.24134585974322e-20 -1.51925487686695 6.14848968356696e-09 MirTarget -0.27209588023852 9.86649572155206e-09 NA NA NA hsa-miR-335-3p RGL1 3.08791651139852 5.31309869723517e-12 -1.51925487686695 6.14848968356696e-09 mirMAP -0.174794168585583 1.86423383826241e-10 NA NA NA hsa-miR-339-5p RGL1 2.68710938429893 3.03134080808154e-16 -1.51925487686695 6.14848968356696e-09 miRNATAP -0.159733332802101 2.0689027816532e-05 NA NA NA hsa-miR-3607-3p RGL1 2.68532138541128 5.66716351955047e-14 -1.51925487686695 6.14848968356696e-09 miRNATAP -0.191736439697375 6.23985952191343e-08 NA NA NA hsa-miR-361-5p RGL1 0.971859117235239 5.30236555707088e-09 -1.51925487686695 6.14848968356696e-09 miRanda -0.4350679965834 1.06242934936196e-08 NA NA NA hsa-miR-429 RGL1 4.48815175680773 2.44117492218206e-17 -1.51925487686695 6.14848968356696e-09 MirTarget;PITA;miRanda;miRNATAP -0.22400228894245 2.76142655928233e-24 NA NA NA hsa-miR-455-5p RGL1 2.2582442061694 1.43472128037398e-13 -1.51925487686695 6.14848968356696e-09 miRanda -0.141574032881026 0.000529309930896539 NA NA NA hsa-miR-582-3p RGL1 0.00876844181512659 0.977126166214707 -1.51925487686695 6.14848968356696e-09 PITA -0.179373195411165 1.92363018222908e-05 NA NA NA hsa-miR-7-1-3p RGL1 1.84950311431067 1.25300363397654e-13 -1.51925487686695 6.14848968356696e-09 MirTarget;mirMAP -0.346252225396895 1.66886813116949e-12 NA NA NA hsa-miR-708-5p RGL1 3.38051631555486 5.12590198690777e-18 -1.51925487686695 6.14848968356696e-09 MirTarget -0.130856434448339 3.06631864971669e-05 NA NA NA hsa-miR-92a-3p RGL1 2.06460102658973 1.44784291084757e-19 -1.51925487686695 6.14848968356696e-09 MirTarget -0.469300277256218 1.64522254975732e-19 NA NA NA hsa-miR-93-5p RGL1 3.03961860136032 1.11672209617395e-24 -1.51925487686695 6.14848968356696e-09 MirTarget;miRNATAP -0.341262481585589 5.09039527306211e-18 NA NA NA hsa-miR-96-5p RGL1 4.89433085814374 1.92000659886961e-31 -1.51925487686695 6.14848968356696e-09 mirMAP -0.267409043318116 5.92197253989501e-22 NA NA NA hsa-miR-361-5p RHOA 0.971859117235239 5.30236555707088e-09 -0.230748867704724 0.030592243709878 MirTarget;PITA;miRanda -0.164727125115389 5.91440692337907e-08 NA NA NA hsa-miR-1306-3p RRAS 1.7835592527682 5.37873730566685e-08 -1.13229828735822 2.92783846173343e-05 MirTarget -0.342468358104518 1.07516903906357e-16 NA NA NA hsa-miR-34a-5p RRAS 1.9016323452565 1.43092834643601e-14 -1.13229828735822 2.92783846173343e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.265547196825665 2.42146653994062e-07 NA NA NA hsa-miR-491-5p RRAS 0.615770352820862 0.0418295628761654 -1.13229828735822 2.92783846173343e-05 miRanda;miRNATAP -0.168893307778227 0.000304382875911956 NA NA NA hsa-miR-106b-5p RRAS2 2.46782146831112 1.36171495805632e-23 -0.336573394273787 0.157806837161319 miRNATAP -0.123529820016572 0.00536363783110175 NA NA NA hsa-miR-23b-3p RRAS2 -0.251132426825047 0.150200321210792 -0.336573394273787 0.157806837161319 MirTarget -0.251243741073941 0.000167519448808664 NA NA NA hsa-miR-29c-3p RRAS2 -0.00968972577705429 0.97099586346872 -0.336573394273787 0.157806837161319 miRNATAP -0.246106967000447 8.92437448436791e-09 NA NA NA hsa-miR-30c-5p RRAS2 0.778774633108 0.000285599212429136 -0.336573394273787 0.157806837161319 miRNATAP -0.224804628188931 2.59774897524192e-05 NA NA NA hsa-miR-30d-5p RRAS2 0.675423997639582 0.00270618816039773 -0.336573394273787 0.157806837161319 miRNATAP -0.270482191429642 9.49506233839001e-08 NA NA NA hsa-miR-320a RRAS2 0.438165828017084 0.0390159073347133 -0.336573394273787 0.157806837161319 miRanda -0.189633132897342 0.000505503813738761 NA NA NA hsa-miR-33a-3p RRAS2 1.72765312072219 1.51784443453521e-07 -0.336573394273787 0.157806837161319 MirTarget -0.122485392721008 0.00123341311117024 NA NA NA hsa-miR-429 RRAS2 4.48815175680773 2.44117492218206e-17 -0.336573394273787 0.157806837161319 PITA;miRanda -0.131885659535421 1.05798206265027e-10 NA NA NA hsa-miR-93-5p RRAS2 3.03961860136032 1.11672209617395e-24 -0.336573394273787 0.157806837161319 miRNAWalker2_validate -0.112014989761344 0.00224791308670307 NA NA NA hsa-miR-30b-5p SHC1 0.800822374912712 0.000133601914525413 0.332364658646822 0.0552326843876597 miRNAWalker2_validate -0.142533545198253 0.000354610953027221 NA NA NA hsa-miR-186-5p SHC2 1.47445398888668 3.0781726595413e-15 -1.55018578792841 2.19238221574848e-05 miRNAWalker2_validate -0.486338062930925 1.3091161584858e-07 NA NA NA hsa-miR-21-3p SHC3 2.19296355304364 4.63665722759779e-15 -0.0912914443010033 0.868441065087702 MirTarget -0.24019806100506 0.00926431768007424 NA NA NA hsa-miR-27b-5p SHC3 0.393316367667332 0.051702301924024 -0.0912914443010033 0.868441065087702 MirTarget -0.375861322748917 0.0047124313277898 NA NA NA hsa-miR-151a-3p SHC4 1.24018761527407 1.08839919675408e-07 -0.664061852285107 0.0809797980708126 MirTarget -0.336040316378969 1.52341310719945e-05 NA NA NA hsa-miR-16-1-3p SHC4 2.56983217111073 3.02262181237943e-20 -0.664061852285107 0.0809797980708126 MirTarget -0.170610956989794 0.00862648125258444 NA NA NA hsa-miR-182-5p SHC4 3.53923166221814 5.07781258121574e-21 -0.664061852285107 0.0809797980708126 MirTarget;miRNATAP -0.221370731435305 1.61837528879945e-06 NA NA NA hsa-miR-186-5p SHC4 1.47445398888668 3.0781726595413e-15 -0.664061852285107 0.0809797980708126 MirTarget;mirMAP -0.436936163507036 4.82954147822387e-06 NA NA NA hsa-miR-20a-3p SHC4 2.92621109947706 2.49504904635375e-17 -0.664061852285107 0.0809797980708126 miRNATAP -0.158052320800603 0.00265826551559992 NA NA NA hsa-miR-324-3p SHC4 2.08739139768981 3.11885987067952e-13 -0.664061852285107 0.0809797980708126 PITA -0.259475329081357 3.07958858687773e-05 NA NA NA hsa-miR-330-3p SHC4 0.876747334239085 0.00073709016089703 -0.664061852285107 0.0809797980708126 PITA;miRNATAP -0.239229821074608 0.000714282954604729 NA NA NA hsa-miR-335-3p SHC4 3.08791651139852 5.31309869723517e-12 -0.664061852285107 0.0809797980708126 mirMAP -0.159565943775788 6.14507787478108e-05 NA NA NA hsa-miR-335-5p SHC4 1.77247705492746 2.22457658872091e-06 -0.664061852285107 0.0809797980708126 miRNAWalker2_validate -0.156249922910202 0.00127940229774996 NA NA NA hsa-miR-361-5p SHC4 0.971859117235239 5.30236555707088e-09 -0.664061852285107 0.0809797980708126 miRanda -0.509976521336161 3.2261223763531e-06 NA NA NA hsa-miR-429 SHC4 4.48815175680773 2.44117492218206e-17 -0.664061852285107 0.0809797980708126 miRanda -0.185896437227615 1.52191673296032e-08 NA NA NA hsa-miR-576-5p SHC4 2.20467023993664 3.4053475193793e-19 -0.664061852285107 0.0809797980708126 mirMAP -0.263898979141107 0.000229359089300697 NA NA NA hsa-miR-590-5p SHC4 3.18300989862077 2.06813568597893e-26 -0.664061852285107 0.0809797980708126 miRanda -0.178180040355136 0.00270587718630816 NA NA NA hsa-miR-664a-3p SHC4 0.634721925861133 0.00520070178640421 -0.664061852285107 0.0809797980708126 mirMAP -0.491996936358744 7.68815407972802e-10 NA NA NA hsa-miR-96-5p SHC4 4.89433085814374 1.92000659886961e-31 -0.664061852285107 0.0809797980708126 TargetScan;miRNATAP -0.205951940033878 6.2356310418156e-07 NA NA NA hsa-let-7a-3p SHOC2 1.42015538786275 7.03375209382654e-13 -0.52061279151768 8.09251091033508e-07 MirTarget -0.116826237559116 3.82176287779716e-06 NA NA NA hsa-miR-106b-5p SHOC2 2.46782146831112 1.36171495805632e-23 -0.52061279151768 8.09251091033508e-07 MirTarget;miRNATAP -0.102953637974932 1.39790836650094e-07 NA NA NA hsa-miR-16-5p SHOC2 1.75824877145857 1.68592440033108e-16 -0.52061279151768 8.09251091033508e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.106144964640756 4.67279288032379e-06 NA NA NA hsa-miR-17-5p SHOC2 3.2710598467455 9.93128340539455e-27 -0.52061279151768 8.09251091033508e-07 MirTarget;TargetScan;miRNATAP -0.100723428882657 7.27501619819843e-11 NA NA NA hsa-miR-181a-5p SHOC2 2.29556023480783 1.8138457900616e-21 -0.52061279151768 8.09251091033508e-07 miRNATAP -0.133311347487291 2.08043412214941e-11 NA NA NA hsa-miR-181b-5p SHOC2 2.49307679431293 3.92829250217627e-20 -0.52061279151768 8.09251091033508e-07 miRNATAP -0.116246049497318 5.66672578589335e-11 NA NA NA hsa-miR-181c-5p SHOC2 1.58587920618301 1.57506918816933e-10 -0.52061279151768 8.09251091033508e-07 miRNATAP -0.129820937373103 7.62891816899753e-11 NA NA NA hsa-miR-186-5p SHOC2 1.47445398888668 3.0781726595413e-15 -0.52061279151768 8.09251091033508e-07 miRNATAP -0.131650298821136 7.34819835496951e-07 NA NA NA hsa-miR-20a-5p SHOC2 3.15577933619191 4.19753346442454e-25 -0.52061279151768 8.09251091033508e-07 MirTarget;miRNATAP -0.102415332843228 4.57244707707096e-11 NA NA NA hsa-miR-361-5p SHOC2 0.971859117235239 5.30236555707088e-09 -0.52061279151768 8.09251091033508e-07 PITA;miRanda -0.116164553822815 0.000152001649227738 NA NA NA hsa-miR-590-3p SHOC2 2.59289455139753 1.03200520972022e-21 -0.52061279151768 8.09251091033508e-07 MirTarget;PITA;miRanda;mirMAP -0.101881988242489 2.65905677111567e-08 NA NA NA hsa-miR-92a-3p SHOC2 2.06460102658973 1.44784291084757e-19 -0.52061279151768 8.09251091033508e-07 miRNAWalker2_validate -0.121519852661386 1.19924275128052e-08 NA NA NA hsa-miR-132-3p SOS1 0.156276992635384 0.408190812100704 -0.16498215834071 0.203173827793335 miRNATAP -0.124479028859718 0.000189720665201441 NA NA NA hsa-miR-140-3p SOS1 0.0608890720479334 0.727716871248724 -0.16498215834071 0.203173827793335 miRNATAP -0.101782613385997 0.00502361468434803 NA NA NA hsa-miR-23a-3p SOS1 1.00493340843378 2.55313889288924e-08 -0.16498215834071 0.203173827793335 mirMAP -0.129314634656678 0.000166578408604821 NA NA NA hsa-miR-26a-2-3p SOS1 0.823520019989974 0.00017092160823769 -0.16498215834071 0.203173827793335 mirMAP -0.118538447529583 3.24943288286622e-05 NA NA NA hsa-miR-27a-3p SOS1 1.66542180327138 4.93775737894805e-13 -0.16498215834071 0.203173827793335 MirTarget;miRNATAP -0.122545061941616 3.0550593865242e-06 NA NA NA hsa-miR-30a-5p SOS1 -0.878357906436456 0.000509952992366057 -0.16498215834071 0.203173827793335 mirMAP;miRNATAP -0.11057365509939 6.32062418728583e-06 NA NA NA hsa-miR-140-5p SOS2 0.844753502512594 3.73722278438606e-05 -0.541773165962052 3.38343002773895e-05 miRanda -0.175305178985449 9.75022022997209e-09 NA NA NA hsa-miR-146b-5p SOS2 1.75587235896724 1.15724631266659e-07 -0.541773165962052 3.38343002773895e-05 miRanda -0.115152479666608 5.46824888444679e-10 NA NA NA hsa-miR-15a-5p SOS2 2.34669284378787 1.69544424500258e-23 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.100823047270651 8.09178891804544e-05 NA NA NA hsa-miR-193a-3p SOS2 1.60460546928078 2.86169793322984e-07 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.115828791088816 4.45409413355469e-09 NA NA NA hsa-miR-199a-5p SOS2 0.592984035153911 0.0674836634175293 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.106315824647688 3.80818848808324e-08 NA NA NA hsa-miR-199b-5p SOS2 0.218704279044827 0.519493319158441 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.110351567625311 2.11664365720639e-09 NA NA NA hsa-miR-21-5p SOS2 2.73773305747971 1.38864982139576e-43 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.17866087041205 3.99766997060001e-10 NA NA NA hsa-miR-424-5p SOS2 1.61930224569578 1.89642549274994e-10 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.10457735471019 1.79360950512032e-05 NA NA NA hsa-miR-454-3p SOS2 2.47234127820054 1.12878018736016e-21 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.106988836200975 7.58489665683655e-06 NA NA NA hsa-miR-493-5p SOS2 0.847772103665986 0.00528678068747754 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.107549440318842 2.05055453955094e-07 NA NA NA hsa-miR-590-3p SOS2 2.59289455139753 1.03200520972022e-21 -0.541773165962052 3.38343002773895e-05 miRanda;mirMAP -0.115775809148697 3.43791025032322e-07 NA NA NA hsa-miR-590-5p SOS2 3.18300989862077 2.06813568597893e-26 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.105807242898967 1.7586879655633e-07 NA NA NA hsa-miR-146b-3p SYNGAP1 1.10569195233795 0.000660632782194023 -0.522359640226928 0.00107362008046586 PITA;miRNATAP -0.169326227490923 2.4064293305054e-13 NA NA NA hsa-miR-29a-3p SYNGAP1 -0.35074463683376 0.161238718982428 -0.522359640226928 0.00107362008046586 miRNATAP -0.130134802454864 2.55589048438646e-05 NA NA NA hsa-miR-361-3p SYNGAP1 1.07367425434318 1.73142774168958e-09 -0.522359640226928 0.00107362008046586 PITA;miRNATAP -0.199119151761022 3.32052438159104e-06 NA NA NA hsa-miR-421 TEK 1.17791565395543 6.78526676976629e-06 -1.75239705645466 2.22611361532503e-08 miRanda -0.261528124066448 7.09099724740353e-06 NA NA NA hsa-miR-455-5p TEK 2.2582442061694 1.43472128037398e-13 -1.75239705645466 2.22611361532503e-08 miRanda -0.220574337227575 5.84401907455115e-06 NA NA NA hsa-miR-142-5p TIAM1 1.17581605694506 0.0018174701991234 0.26066582137389 0.380250873765661 MirTarget;PITA;miRNATAP -0.114131748659499 0.00257919227836484 NA NA NA hsa-miR-146b-5p TIAM1 1.75587235896724 1.15724631266659e-07 0.26066582137389 0.380250873765661 miRanda -0.193427411386277 5.05600176421554e-06 NA NA NA hsa-miR-21-3p TIAM1 2.19296355304364 4.63665722759779e-15 0.26066582137389 0.380250873765661 MirTarget -0.157914297510883 0.00146770766603209 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-221-3p TIAM1 0.451556679024397 0.0909808299917811 0.26066582137389 0.380250873765661 miRNAWalker2_validate -0.202177835199503 0.000167681575838687 NA NA NA hsa-miR-29a-3p TIAM1 -0.35074463683376 0.161238718982428 0.26066582137389 0.380250873765661 miRNATAP -0.207053871726635 0.000314250259436748 NA NA NA hsa-miR-29a-5p TIAM1 1.46749674755271 3.34605004270294e-07 0.26066582137389 0.380250873765661 MirTarget -0.279412000293213 5.99246052833918e-08 NA NA NA hsa-miR-338-3p TIAM1 0.453166438193782 0.144583389707558 0.26066582137389 0.380250873765661 miRanda -0.158274334232953 0.000611460080075842 NA NA NA hsa-miR-1-3p VEGFA -3.48370702447685 1.98579484008516e-13 0.471653090802802 0.0989904385682923 MirTarget -0.202978528176548 1.57292170658149e-13 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -3.38501431117712 1.32336729742128e-13 0.471653090802802 0.0989904385682923 miRNAWalker2_validate -0.190996958246616 2.70660605752725e-11 NA NA NA hsa-miR-134-5p VEGFA 0.141163006984518 0.655334296084178 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.180227374251871 3.58435465670397e-05 NA NA NA hsa-miR-145-5p VEGFA -1.55259331973517 9.97889123247165e-07 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.277645238248207 4.72205041776188e-11 24966896;24781864;22472569 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically ;metastasis; bladder cancer;thyroid cancer;sarcoma hsa-miR-150-5p VEGFA -0.105827294491332 0.799351458244375 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.164137084593398 6.0374913950269e-07 NA NA NA hsa-miR-195-5p VEGFA -1.44753678070504 8.70594292149271e-09 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.21863878149299 5.11037236008283e-05 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.592984035153911 0.0674836634175293 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.205612739501636 1.1489897892283e-06 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.218704279044827 0.519493319158441 0.471653090802802 0.0989904385682923 miRanda -0.175899050515122 1.43171320791549e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.35074463683376 0.161238718982428 0.471653090802802 0.0989904385682923 MirTarget -0.313847513848792 9.68544057650496e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-342-3p VEGFA 1.49115144672245 1.43879249744621e-07 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.166390639835536 0.000539599594707828 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERĪ± mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA 0.0654362503857184 0.722673188879465 0.471653090802802 0.0989904385682923 MirTarget -0.254824056474554 0.000792850845311603 NA NA NA hsa-miR-655-3p VEGFA 0.485339318272148 0.137014658258732 0.471653090802802 0.0989904385682923 MirTarget -0.164823030617487 0.000126415331270495 NA NA NA hsa-miR-128-3p VEGFC 1.63756041666078 6.79626586407187e-14 -0.457873556695705 0.178610332401836 miRNAWalker2_validate;MirTarget -0.377058704312277 2.16798927147771e-07 26722309;25001183 miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells;Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways metastasis; bladder cancer;lung squamous cell cancer hsa-miR-185-3p ZAP70 2.3922478518806 1.3373426768452e-14 -0.480657788022104 0.27260052165701 MirTarget -0.216424543038763 0.00103796550886786 NA NA NA