miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-129-5p ACTB -2.56914016541176 2.36237896095709e-06 0.399309941883647 0.0152878053028372 miRanda -0.105007519830653 4.11903439172899e-07 NA NA NA hsa-miR-7-1-3p ACTB 0.709309110750947 0.0412301737463194 0.399309941883647 0.0152878053028372 MirTarget -0.12859545336889 0.00011132337540404 NA NA NA hsa-miR-199a-5p ACTG1 0.371973504507027 0.232661597228763 0.180150665307615 0.357159122221427 miRanda -0.125036540943548 0.00506764179473425 NA NA NA hsa-miR-199b-5p ACTG1 0.124595928096068 0.678156859366405 0.180150665307615 0.357159122221427 miRanda -0.138897952864464 0.00273552516456435 NA NA NA hsa-miR-127-5p AMOT 0.684144175589776 0.021634535736883 -0.455856990596581 0.488692516190368 PITA -0.448590918221247 0.00439021779574674 NA NA NA hsa-miR-203a-3p AMOT 1.44736908507496 0.0394116388736904 -0.455856990596581 0.488692516190368 MirTarget -0.22165749040611 0.000762406114906488 NA NA NA hsa-miR-205-5p AMOT 3.13520672931882 0.0293226471971167 -0.455856990596581 0.488692516190368 MirTarget;miRNATAP -0.198276103008711 1.55089077673304e-10 26239614 MicroRNA 205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression; In the present study miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region 3'-UTR of AMOT in breast cancer MCF-7 cells by luciferase assay; miR-205 and small interfering RNA siRNA-mediated AMOT-knockdown experiments revealed that miR-205 significantly inhibited the proliferation and the invasion of MCF-7 cells through a decrease in the expression of AMOT yet had no effect on apoptosis; Furthermore we observed that the overexpression of AMOT partially reversed the inhibitory effect of miR-205 on the growth and the invasion of MCF-7 cells; The data indicated that miR-205 regulated the proliferation and the invasion of breast cancer cells through suppression of AMOT expression at least partly; Therefore the disordered decreased expression of miR-205 and the resulting AMOT upregulation contributes to breast carcinogenesis and miR-205-AMOT represents a new potential therapeutic target for the treatment of breast carcinoma tumorigenesis breast cancer hsa-miR-22-3p AMOT 0.0312103895892015 0.845091185648687 -0.455856990596581 0.488692516190368 MirTarget;miRNATAP -1.73977801104384 4.15417703388042e-09 NA NA NA hsa-miR-2355-3p AMOT 0.982963823342009 0.0229275810851348 -0.455856990596581 0.488692516190368 MirTarget;miRNATAP -0.630856848399487 2.4996867370651e-09 NA NA NA hsa-miR-34c-3p AMOT 2.25273698056457 9.06191072601281e-05 -0.455856990596581 0.488692516190368 MirTarget;mirMAP -0.31770435628125 7.10261798981128e-05 NA NA NA hsa-miR-34c-5p AMOT 2.20632574870337 0.000379662996168678 -0.455856990596581 0.488692516190368 miRanda -0.273647032874238 0.000224306557382748 NA NA NA hsa-miR-944 AMOT 3.33123095809751 0.0177835044930391 -0.455856990596581 0.488692516190368 mirMAP;miRNATAP -0.264612839852069 1.1345636689132e-12 NA NA NA hsa-miR-106b-5p APC 1.70863907461894 2.04074794107142e-08 -0.239280203141734 0.199198077121656 miRNAWalker2_validate;miRTarBase -0.138367689545459 0.000906560592273728 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-107 APC 0.904627575346218 4.67936495073904e-05 -0.239280203141734 0.199198077121656 miRanda -0.161111680164056 0.00648694313936219 NA NA NA hsa-miR-320b APC 1.11183660885284 0.000497971211648503 -0.239280203141734 0.199198077121656 miRanda -0.159142024116119 8.51492262456867e-05 NA NA NA hsa-miR-20a-3p APC2 1.13957127410163 0.000451087640268489 -1.50664575100959 0.000134622121604578 mirMAP -0.267324795058684 0.00209631286402744 NA NA NA hsa-miR-221-5p APC2 1.88626894114756 8.2644671350768e-08 -1.50664575100959 0.000134622121604578 mirMAP -0.343003530849754 3.79548142088197e-05 NA NA NA hsa-miR-345-5p APC2 1.83686164833727 1.1036889735857e-08 -1.50664575100959 0.000134622121604578 mirMAP -0.2896602507868 0.000690699561951634 NA NA NA hsa-miR-625-5p APC2 0.537211086526376 0.203801009380384 -1.50664575100959 0.000134622121604578 mirMAP -0.310278994898225 3.29632580880746e-06 NA NA NA hsa-miR-129-5p AREG -2.56914016541176 2.36237896095709e-06 0.455946668090932 0.445206623022083 miRanda -0.383851729645084 3.64828245349376e-07 NA NA NA hsa-miR-205-5p AXIN2 3.13520672931882 0.0293226471971167 -0.656518824041935 0.251774598708084 miRNATAP -0.169412182908091 3.69637622369516e-10 NA NA NA hsa-miR-34c-5p AXIN2 2.20632574870337 0.000379662996168678 -0.656518824041935 0.251774598708084 miRanda -0.212743620762748 0.00103007883259358 NA NA NA hsa-miR-944 AXIN2 3.33123095809751 0.0177835044930391 -0.656518824041935 0.251774598708084 MirTarget;PITA;miRNATAP -0.202866625018192 7.07646660120189e-10 NA NA NA hsa-let-7a-2-3p BBC3 0.195895719455896 0.643556335039042 1.16438832735563 0.000138050719155024 MirTarget -0.189649631349489 0.000323992880583244 NA NA NA hsa-miR-149-5p BBC3 0.706277554734069 0.296848731347677 1.16438832735563 0.000138050719155024 miRNATAP -0.12753681248736 7.31829046434304e-05 NA NA NA hsa-miR-27b-3p BBC3 0.0836323965901755 0.725273923274 1.16438832735563 0.000138050719155024 miRNATAP -0.254737303455527 0.00692776633122051 NA NA NA hsa-miR-101-3p BIRC5 -0.451263906815861 0.0283387250173031 3.818683410724 2.62809126487231e-26 miRNAWalker2_validate -0.517331943967778 0.000329671500837059 NA NA NA hsa-miR-10a-5p BIRC5 -0.470861534765518 0.148803248989189 3.818683410724 2.62809126487231e-26 miRNAWalker2_validate -0.438205535774576 7.0764345983513e-07 NA NA NA hsa-miR-30c-5p BIRC5 -0.983130268805942 4.60419218706127e-05 3.818683410724 2.62809126487231e-26 miRNAWalker2_validate -0.447900241296508 0.000187670064577249 NA NA NA hsa-miR-338-3p BIRC5 -0.959276231066179 0.0191473351014091 3.818683410724 2.62809126487231e-26 miRanda -0.278120904850544 8.16306439817973e-05 NA NA NA hsa-miR-375 BIRC5 -2.94506033785642 0.00570147601654791 3.818683410724 2.62809126487231e-26 miRanda -0.114715248193444 1.87356520259604e-05 NA NA NA hsa-miR-335-3p BMP2 2.5197689063267 2.20084506976733e-09 -0.330988655536076 0.460129330608628 mirMAP -0.232514170508169 0.0012787026131925 NA NA NA hsa-miR-944 BMP5 3.33123095809751 0.0177835044930391 -2.34444457381683 0.00471244639883285 mirMAP -0.27049548335463 2.46130314941754e-08 NA NA NA hsa-miR-130b-3p BMP6 1.32714007211004 4.78676252285191e-05 -0.607148038594669 0.050793505437047 MirTarget -0.177587576098675 0.00798603562278452 NA NA NA hsa-miR-301b-3p BMP6 1.10080095582241 0.0715568440482997 -0.607148038594669 0.050793505437047 MirTarget -0.173537184980346 0.000418327921911699 NA NA NA hsa-miR-320a BMP6 0.593888711838028 0.011897419390526 -0.607148038594669 0.050793505437047 PITA;miRanda -0.283951616663656 0.0026528073370173 NA NA NA hsa-miR-320c BMP6 0.455072851945474 0.240613785444485 -0.607148038594669 0.050793505437047 PITA;miRanda -0.188128799746124 0.00454323889475482 NA NA NA hsa-miR-338-3p BMP7 -0.959276231066179 0.0191473351014091 0.767143453660681 0.311782695394875 miRanda -0.539549909974716 3.17130115467174e-05 NA NA NA hsa-miR-3614-3p BMP7 0.816988052098069 0.0143572924352078 0.767143453660681 0.311782695394875 mirMAP -0.559588260418171 0.000793664362435681 NA NA NA hsa-miR-362-3p BMP7 -0.0349414695893027 0.913780708043777 0.767143453660681 0.311782695394875 miRanda -0.473280486099214 0.00508089454645054 NA NA NA hsa-miR-142-5p BMPR1A 1.55592486377018 6.69269968016779e-06 -0.554560788147423 0.000858671444638689 MirTarget -0.142737084234454 1.73421403733695e-05 NA NA NA hsa-miR-142-5p BMPR1B 1.55592486377018 6.69269968016779e-06 -2.08100996213164 0.00523375550086192 mirMAP -0.425655330175697 0.00502812760464784 NA NA NA hsa-miR-16-2-3p BMPR1B 1.8048179609245 2.83095715136409e-09 -2.08100996213164 0.00523375550086192 mirMAP -0.504181113486021 0.00294973264228178 NA NA NA hsa-miR-2110 BMPR1B 0.759864042760204 0.0723961390557655 -2.08100996213164 0.00523375550086192 MirTarget -0.401074685460365 0.00168259527734797 NA NA NA hsa-miR-29a-5p BMPR1B 0.585084040404152 0.023014129158495 -2.08100996213164 0.00523375550086192 MirTarget;mirMAP;miRNATAP -0.804910330553732 0.000104039897505579 NA NA NA hsa-miR-375 BMPR1B -2.94506033785642 0.00570147601654791 -2.08100996213164 0.00523375550086192 miRNATAP -0.129894505476681 0.00888218263127222 NA NA NA hsa-miR-429 BMPR1B 1.40182602301928 0.00900426780286475 -2.08100996213164 0.00523375550086192 miRNATAP -0.375950077550647 0.000123688636547986 NA NA NA hsa-miR-501-5p BMPR1B 0.266919328110625 0.454779001968586 -2.08100996213164 0.00523375550086192 mirMAP -0.457400904933951 0.00232428578799946 NA NA NA hsa-miR-7-1-3p BMPR1B 0.709309110750947 0.0412301737463194 -2.08100996213164 0.00523375550086192 MirTarget -0.481185121814777 0.00173266351275803 NA NA NA hsa-let-7f-1-3p BMPR2 1.28704406797397 1.17954701106157e-06 -0.105330983018756 0.575708531027606 MirTarget -0.181733036095241 0.000199405815274417 NA NA NA hsa-miR-106b-5p BMPR2 1.70863907461894 2.04074794107142e-08 -0.105330983018756 0.575708531027606 MirTarget;miRNATAP -0.220326548518709 8.30675178315963e-08 NA NA NA hsa-miR-128-3p BMPR2 0.98280381420517 5.77641850797209e-05 -0.105330983018756 0.575708531027606 miRNAWalker2_validate -0.224647224422691 2.5471475009724e-05 NA NA NA hsa-miR-130b-3p BMPR2 1.32714007211004 4.78676252285191e-05 -0.105330983018756 0.575708531027606 MirTarget;miRNATAP -0.184162905503272 2.91097881726425e-06 NA NA NA hsa-miR-148b-3p BMPR2 0.295175884456199 0.17466422420702 -0.105330983018756 0.575708531027606 mirMAP -0.263842554613049 1.70754919518769e-05 NA NA NA hsa-miR-16-2-3p BMPR2 1.8048179609245 2.83095715136409e-09 -0.105330983018756 0.575708531027606 mirMAP -0.136812272530867 0.00111941025345627 NA NA NA hsa-miR-17-5p BMPR2 1.65862087862483 8.45603406215941e-08 -0.105330983018756 0.575708531027606 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.147466746206561 0.000369221474443662 NA NA NA hsa-miR-182-5p BMPR2 0.887369486030646 0.0310640781418789 -0.105330983018756 0.575708531027606 mirMAP -0.115753456230592 0.000289543819585992 NA NA NA hsa-miR-185-5p BMPR2 1.14351510556643 1.07346945085714e-08 -0.105330983018756 0.575708531027606 MirTarget -0.201872274289143 0.00193021536942469 NA NA NA hsa-miR-186-5p BMPR2 0.149964130725901 0.434709542998771 -0.105330983018756 0.575708531027606 mirMAP -0.227948818901681 0.00129863782609481 NA NA NA hsa-miR-19a-3p BMPR2 1.26669687448473 0.000105972838514412 -0.105330983018756 0.575708531027606 miRNAWalker2_validate;MirTarget;miRNATAP -0.103584453990761 0.00994947769865406 NA NA NA hsa-miR-19b-3p BMPR2 0.759818275708988 0.00652779573186786 -0.105330983018756 0.575708531027606 miRNAWalker2_validate;MirTarget;miRNATAP -0.128054345458489 0.00717493538683918 NA NA NA hsa-miR-20a-5p BMPR2 1.4503375861709 5.7813456424762e-07 -0.105330983018756 0.575708531027606 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118773128746103 0.00800851325365646 NA NA NA hsa-miR-25-3p BMPR2 1.00604871526544 0.000421838061147906 -0.105330983018756 0.575708531027606 miRNATAP -0.146201828223198 0.00152830866656552 NA NA NA hsa-miR-26b-5p BMPR2 -0.301646326928219 0.160081421968103 -0.105330983018756 0.575708531027606 miRNAWalker2_validate -0.207478277501161 0.000949702346176627 NA NA NA hsa-miR-301b-3p BMPR2 1.10080095582241 0.0715568440482997 -0.105330983018756 0.575708531027606 MirTarget -0.128476428241357 1.10331787268427e-05 NA NA NA hsa-miR-32-3p BMPR2 0.583525764322974 0.11837203008551 -0.105330983018756 0.575708531027606 mirMAP -0.122132023675059 0.00224875357236313 NA NA NA hsa-miR-32-5p BMPR2 0.415247682945382 0.106458022460373 -0.105330983018756 0.575708531027606 miRNATAP -0.245937946825618 1.5141188408753e-06 NA NA NA hsa-miR-320b BMPR2 1.11183660885284 0.000497971211648503 -0.105330983018756 0.575708531027606 mirMAP -0.158989832181878 9.93096953084233e-05 NA NA NA hsa-miR-330-3p BMPR2 0.798460296022179 0.00746538156533435 -0.105330983018756 0.575708531027606 PITA;miRNATAP -0.186560653499869 2.13480477796419e-05 NA NA NA hsa-miR-335-3p BMPR2 2.5197689063267 2.20084506976733e-09 -0.105330983018756 0.575708531027606 mirMAP -0.131924228903938 9.18499587397887e-06 NA NA NA hsa-miR-33a-3p BMPR2 0.347011402017138 0.321709379745392 -0.105330983018756 0.575708531027606 mirMAP -0.164301063402173 3.32908750226742e-05 NA NA NA hsa-miR-33a-5p BMPR2 0.407757858040717 0.321429014317207 -0.105330983018756 0.575708531027606 mirMAP -0.197572971800639 1.87581662654466e-10 NA NA NA hsa-miR-33b-5p BMPR2 0.267227362818466 0.614814331176942 -0.105330983018756 0.575708531027606 mirMAP -0.150984197348101 2.01496506606855e-06 NA NA NA hsa-miR-361-5p BMPR2 0.407725414130987 0.0181260969156347 -0.105330983018756 0.575708531027606 MirTarget;miRanda;mirMAP;miRNATAP -0.216918196240751 0.00619844750464207 NA NA NA hsa-miR-374a-3p BMPR2 0.0420912023953779 0.851478041312794 -0.105330983018756 0.575708531027606 MirTarget;miRNATAP -0.169121865940957 0.00497233009139577 NA NA NA hsa-miR-378a-5p BMPR2 -0.557166502179376 0.0344581590006454 -0.105330983018756 0.575708531027606 MirTarget -0.156718830215627 0.00196622339955063 NA NA NA hsa-miR-424-3p BMPR2 0.860888512744971 0.0234638352065231 -0.105330983018756 0.575708531027606 mirMAP -0.132784667839888 0.000312344159948747 NA NA NA hsa-miR-532-5p BMPR2 0.313080805824184 0.252248939356301 -0.105330983018756 0.575708531027606 PITA -0.135780855674448 0.00563230638100678 NA NA NA hsa-miR-582-3p BMPR2 -0.412897415951272 0.202939245403793 -0.105330983018756 0.575708531027606 PITA;miRNATAP -0.152754169716967 0.000182100945098051 NA NA NA hsa-miR-590-3p BMPR2 1.11654983899947 0.000160782154924864 -0.105330983018756 0.575708531027606 MirTarget;miRanda;mirMAP;miRNATAP -0.200328698544334 4.60532058921911e-06 NA NA NA hsa-miR-590-5p BMPR2 1.04171442093217 0.000272475544954865 -0.105330983018756 0.575708531027606 MirTarget;PITA;miRNATAP -0.234846805973338 1.73272714942428e-07 NA NA NA hsa-miR-625-3p BMPR2 -0.185298294014366 0.626215541224408 -0.105330983018756 0.575708531027606 mirMAP -0.107684633830689 0.00206070319037939 NA NA NA hsa-miR-629-5p BMPR2 1.06377074768516 0.000536624707722274 -0.105330983018756 0.575708531027606 mirMAP -0.158364335178657 0.0002070765285862 NA NA NA hsa-miR-671-5p BMPR2 0.947458646379882 0.0024732430914236 -0.105330983018756 0.575708531027606 miRNATAP -0.117054452966849 0.00559609772404471 NA NA NA hsa-miR-769-5p BMPR2 1.14821899306381 1.27143750879772e-06 -0.105330983018756 0.575708531027606 miRNATAP -0.227656172053625 3.02990231628743e-05 NA NA NA hsa-miR-92a-3p BMPR2 1.2209325870225 6.8757197708107e-06 -0.105330983018756 0.575708531027606 miRNAWalker2_validate;miRNATAP -0.202746425006159 2.02941015309487e-05 NA NA NA hsa-miR-93-3p BMPR2 1.88964231421793 1.80075645722786e-08 -0.105330983018756 0.575708531027606 miRNAWalker2_validate -0.133293027998464 0.000453296291514109 NA NA NA hsa-miR-96-5p BMPR2 1.14243043653372 0.00942969392739105 -0.105330983018756 0.575708531027606 mirMAP -0.121251235305903 9.91743825333832e-05 NA NA NA hsa-miR-103a-3p BTRC 0.840525139266028 5.83536475789158e-07 -0.391199450899332 0.00795763621626704 MirTarget;miRNATAP -0.187654641826057 0.0025672940997127 NA NA NA hsa-miR-148b-5p BTRC 1.04409494910362 0.00195860954157389 -0.391199450899332 0.00795763621626704 mirMAP -0.106464268091461 0.000499345202306096 NA NA NA hsa-miR-15a-5p BTRC 1.03783090449383 7.40334108980898e-07 -0.391199450899332 0.00795763621626704 miRNAWalker2_validate;MirTarget;miRNATAP -0.189063431412031 0.000109130867374999 NA NA NA hsa-miR-15b-5p BTRC 1.62046407540723 5.42152621571078e-09 -0.391199450899332 0.00795763621626704 MirTarget;miRNATAP -0.111636139180706 0.00209148928736224 NA NA NA hsa-miR-16-1-3p BTRC 1.43227522002564 3.70920454953168e-08 -0.391199450899332 0.00795763621626704 mirMAP -0.10318441312737 0.00834754598605546 NA NA NA hsa-miR-16-5p BTRC 1.00515772948091 5.33912942007619e-06 -0.391199450899332 0.00795763621626704 miRNAWalker2_validate;MirTarget;miRNATAP -0.147424183939874 0.00162833764839028 NA NA NA hsa-miR-320a BTRC 0.593888711838028 0.011897419390526 -0.391199450899332 0.00795763621626704 miRNAWalker2_validate;PITA -0.160951616893512 0.000277705963309329 NA NA NA hsa-miR-320b BTRC 1.11183660885284 0.000497971211648503 -0.391199450899332 0.00795763621626704 PITA -0.11478354656647 0.000364840371120692 NA NA NA hsa-miR-454-3p BTRC 0.625199142970745 0.0134890997402741 -0.391199450899332 0.00795763621626704 mirMAP -0.187413660154076 4.34836837000021e-06 NA NA NA hsa-miR-505-3p BTRC 0.82660100642669 0.00111666333288398 -0.391199450899332 0.00795763621626704 MirTarget -0.119302766264877 0.0037225914004262 NA NA NA hsa-miR-338-3p CCND1 -0.959276231066179 0.0191473351014091 0.62464034212269 0.131198685408586 miRNAWalker2_validate;miRTarBase;miRanda -0.237799286777961 0.000859583563159798 NA NA NA hsa-let-7a-3p CCND2 0.503048155002889 0.0411145454335299 -0.495732246530821 0.299995013548082 mirMAP -0.539007488034469 9.58303749078928e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.21838629112113 0.296038413622566 -0.495732246530821 0.299995013548082 mirMAP -0.458425126620734 0.00587678366196967 NA NA NA hsa-miR-106b-5p CCND2 1.70863907461894 2.04074794107142e-08 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.420111135029172 8.79445971678554e-05 NA NA NA hsa-miR-130b-5p CCND2 0.701350393759937 0.0510142718395002 -0.495732246530821 0.299995013548082 mirMAP -0.393986053261913 2.48361314637284e-05 NA NA NA hsa-miR-141-3p CCND2 1.45548825076434 0.00115958850961764 -0.495732246530821 0.299995013548082 MirTarget;TargetScan -0.213829265059233 0.00435932519246045 NA NA NA hsa-miR-15b-5p CCND2 1.62046407540723 5.42152621571078e-09 -0.495732246530821 0.299995013548082 miRNATAP -0.436574112059407 0.000206222006606723 NA NA NA hsa-miR-16-2-3p CCND2 1.8048179609245 2.83095715136409e-09 -0.495732246530821 0.299995013548082 mirMAP -0.54923627359894 1.83952504317926e-07 NA NA NA hsa-miR-16-5p CCND2 1.00515772948091 5.33912942007619e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRNATAP -0.666404634405191 9.74095569654959e-06 NA NA NA hsa-miR-181a-2-3p CCND2 0.901732254836667 0.000830304681396734 -0.495732246530821 0.299995013548082 mirMAP -0.381747755391939 0.00236274066260059 NA NA NA hsa-miR-182-5p CCND2 0.887369486030646 0.0310640781418789 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;miRTarBase;miRNATAP -0.320494097434122 8.56279904949731e-05 NA NA NA hsa-miR-183-5p CCND2 1.65900927871187 0.000522025364980187 -0.495732246530821 0.299995013548082 miRNATAP -0.293018901580787 2.29962975856133e-05 NA NA NA hsa-miR-19b-3p CCND2 0.759818275708988 0.00652779573186786 -0.495732246530821 0.299995013548082 miRNAWalker2_validate;MirTarget;miRNATAP -0.321137891620492 0.0085283453454723 NA NA NA hsa-miR-21-3p CCND2 1.75245546017565 2.36505176715025e-10 -0.495732246530821 0.299995013548082 mirMAP -0.330852598235875 0.00510140773909108 NA NA NA hsa-miR-224-3p CCND2 1.52422171450716 0.00650463542340912 -0.495732246530821 0.299995013548082 mirMAP -0.268591207673576 3.7771965471366e-05 NA NA NA hsa-miR-26b-5p CCND2 -0.301646326928219 0.160081421968103 -0.495732246530821 0.299995013548082 mirMAP;miRNATAP -0.575426727790569 0.00033543015515606 NA NA NA hsa-miR-301a-3p CCND2 1.44721900431161 6.35068481036652e-06 -0.495732246530821 0.299995013548082 miRNAWalker2_validate -0.383757128016972 0.0002041077399091 NA NA NA hsa-miR-3065-3p CCND2 -1.03551124329864 0.0218397494946288 -0.495732246530821 0.299995013548082 MirTarget;miRNATAP -0.202763155868079 0.00685463393219998 NA NA NA hsa-miR-3065-5p CCND2 -0.241623656423063 0.633116553078159 -0.495732246530821 0.299995013548082 mirMAP -0.236172852888811 0.000570437819651464 NA NA NA hsa-miR-424-5p CCND2 1.08509868581983 0.000420473853818268 -0.495732246530821 0.299995013548082 miRNATAP -0.393741408465626 0.000302491529945387 NA NA NA hsa-miR-429 CCND2 1.40182602301928 0.00900426780286475 -0.495732246530821 0.299995013548082 miRNATAP -0.193697975832347 0.00200087926732012 NA NA NA hsa-miR-450b-5p CCND2 0.46157963033014 0.13273722727895 -0.495732246530821 0.299995013548082 MirTarget;PITA;miRNATAP -0.319300360536976 0.00413356428949538 NA NA NA hsa-miR-590-3p CCND2 1.11654983899947 0.000160782154924864 -0.495732246530821 0.299995013548082 miRanda;mirMAP -0.332566390160307 0.00348233876262983 NA NA NA hsa-miR-590-5p CCND2 1.04171442093217 0.000272475544954865 -0.495732246530821 0.299995013548082 mirMAP -0.40586994965179 0.000547583893303904 NA NA NA hsa-miR-9-3p CCND2 0.330346058941473 0.541111939982661 -0.495732246530821 0.299995013548082 MirTarget;mirMAP;miRNATAP -0.190791407012111 0.00360684983294818 NA NA NA hsa-miR-93-5p CCND2 1.7515174434778 1.59386482413883e-08 -0.495732246530821 0.299995013548082 miRNATAP -0.321341054229317 0.00244079386586045 NA NA NA hsa-miR-96-5p CCND2 1.14243043653372 0.00942969392739105 -0.495732246530821 0.299995013548082 TargetScan;miRNATAP -0.334672732851839 2.58915737933556e-05 NA NA NA hsa-miR-96-5p CCND3 1.14243043653372 0.00942969392739105 0.0356607593991125 0.883520357560836 TargetScan -0.119818202566509 0.00327749541512401 NA NA NA hsa-miR-452-3p CRB2 2.2028815467959 0.00185370432491004 -0.853836614830299 0.101576641749538 MirTarget -0.151543573882584 0.00971530193061285 NA NA NA hsa-let-7b-5p CSNK1D 0.0582902155815681 0.781400138984745 -0.137440694547122 0.22913892324825 miRNAWalker2_validate -0.110160493968645 0.00445554723293037 NA NA NA hsa-miR-30a-3p CSNK1E -1.73205137750899 3.2425754511091e-07 0.533282071308649 0.00079729681676374 miRNATAP -0.107522404263993 0.000908903214401079 NA NA NA hsa-miR-30c-5p CSNK1E -0.983130268805942 4.60419218706127e-05 0.533282071308649 0.00079729681676374 miRNAWalker2_validate -0.180466524879097 9.72207891664326e-05 NA NA NA hsa-miR-30d-3p CSNK1E -0.545113326540761 0.0433733076874155 0.533282071308649 0.00079729681676374 miRNATAP -0.137936768972899 0.00106617923645423 NA NA NA hsa-miR-149-5p CTGF 0.706277554734069 0.296848731347677 -1.47742471982237 0.000456514926161835 miRNATAP -0.153012264832564 0.00059129662846367 NA NA NA hsa-miR-16-2-3p CTGF 1.8048179609245 2.83095715136409e-09 -1.47742471982237 0.000456514926161835 MirTarget -0.679580410767606 7.12759308813084e-14 NA NA NA hsa-miR-18a-5p CTGF 2.20211504140984 1.78678887916334e-09 -1.47742471982237 0.000456514926161835 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.383153713276625 9.14496065795554e-07 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 1.26669687448473 0.000105972838514412 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.357350420170976 8.58849496642616e-05 NA NA NA hsa-miR-19b-3p CTGF 0.759818275708988 0.00652779573186786 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.417275867420144 0.000111520843196417 NA NA NA hsa-miR-26b-3p CTGF -0.0103961389461977 0.965770899625511 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.493173752411661 9.45407994366529e-05 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-26b-5p CTGF -0.301646326928219 0.160081421968103 -1.47742471982237 0.000456514926161835 miRNATAP -0.38771125707237 0.00727109512481099 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-3065-5p CTGF -0.241623656423063 0.633116553078159 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.252381747273136 3.35401318339972e-05 NA NA NA hsa-miR-330-3p CTGF 0.798460296022179 0.00746538156533435 -1.47742471982237 0.000456514926161835 MirTarget;PITA;miRNATAP -0.428513987299392 2.00855570170052e-05 NA NA NA hsa-miR-3662 CTGF 1.82780708047676 0.0054036501346178 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.17047411695915 0.00404607160545695 NA NA NA hsa-miR-577 CTGF 0.911619788986754 0.2256062124148 -1.47742471982237 0.000456514926161835 miRNATAP -0.122641018049418 0.00291470486504945 NA NA NA hsa-miR-590-3p CTGF 1.11654983899947 0.000160782154924864 -1.47742471982237 0.000456514926161835 PITA;miRanda -0.450291396404158 7.02135050790325e-06 NA NA NA hsa-miR-181c-5p CTNNA1 0.336826967681288 0.112932307913601 -0.233912608907648 0.150193548359816 MirTarget -0.165328025186258 0.00259305145055098 NA NA NA hsa-miR-181d-5p CTNNA1 0.65192727601808 0.0143398117228333 -0.233912608907648 0.150193548359816 MirTarget -0.151772299611807 0.00041532539305361 NA NA NA hsa-miR-421 CTNNA1 1.80720854070385 1.59709651202848e-07 -0.233912608907648 0.150193548359816 miRanda -0.102019421400309 0.00152461313483608 NA NA NA hsa-miR-21-3p CTNNA3 1.75245546017565 2.36505176715025e-10 -2.20741230208589 0.00434765254584633 MirTarget -0.977445075455283 2.13224883797138e-07 NA NA NA hsa-miR-320b CTNNA3 1.11183660885284 0.000497971211648503 -2.20741230208589 0.00434765254584633 miRanda -0.608820188561916 0.000388983118345613 NA NA NA hsa-miR-330-5p CTNNA3 0.488365986827708 0.0512207630808233 -2.20741230208589 0.00434765254584633 miRanda -0.761977277863226 0.000634255437124448 NA NA NA hsa-miR-590-3p CTNNA3 1.11654983899947 0.000160782154924864 -2.20741230208589 0.00434765254584633 miRanda -0.997668111601384 3.49502376671948e-08 NA NA NA hsa-miR-940 CTNNA3 1.64406174271686 0.000690854900107004 -2.20741230208589 0.00434765254584633 MirTarget -0.598195639206016 5.64691687868242e-06 NA NA NA hsa-let-7g-3p DLG2 0.64979533805273 0.0103084600883006 -3.9664071716655 4.52363848356762e-09 miRNATAP -0.985031314749723 4.33324368500901e-07 NA NA NA hsa-miR-1301-3p DLG2 1.59017279464031 4.6624715470094e-06 -3.9664071716655 4.52363848356762e-09 MirTarget -0.497417885265635 0.000408090405820419 NA NA NA hsa-miR-130b-5p DLG2 0.701350393759937 0.0510142718395002 -3.9664071716655 4.52363848356762e-09 miRNATAP -0.686609906847028 5.02567651525719e-07 NA NA NA hsa-miR-135b-5p DLG2 4.09156383496059 1.32294295002438e-12 -3.9664071716655 4.52363848356762e-09 MirTarget -0.429901737097593 6.33500524383323e-08 NA NA NA hsa-miR-148b-3p DLG2 0.295175884456199 0.17466422420702 -3.9664071716655 4.52363848356762e-09 miRNAWalker2_validate;MirTarget -0.947110268723192 4.68136848126723e-05 NA NA NA hsa-miR-148b-5p DLG2 1.04409494910362 0.00195860954157389 -3.9664071716655 4.52363848356762e-09 mirMAP -0.469122646844913 0.00147792437912477 NA NA NA hsa-miR-15b-3p DLG2 1.75738933306437 3.00554466232543e-08 -3.9664071716655 4.52363848356762e-09 mirMAP -1.06069143083687 2.33382478521387e-13 NA NA NA hsa-miR-16-2-3p DLG2 1.8048179609245 2.83095715136409e-09 -3.9664071716655 4.52363848356762e-09 mirMAP -1.0698932843013 1.41047924668463e-12 NA NA NA hsa-miR-17-5p DLG2 1.65862087862483 8.45603406215941e-08 -3.9664071716655 4.52363848356762e-09 mirMAP -1.02431589350012 8.683644636238e-12 NA NA NA hsa-miR-182-5p DLG2 0.887369486030646 0.0310640781418789 -3.9664071716655 4.52363848356762e-09 miRNATAP -0.486398031612898 5.27211006301965e-05 NA NA NA hsa-miR-185-5p DLG2 1.14351510556643 1.07346945085714e-08 -3.9664071716655 4.52363848356762e-09 MirTarget;miRNATAP -1.84690039780689 9.20301821613015e-16 NA NA NA hsa-miR-186-5p DLG2 0.149964130725901 0.434709542998771 -3.9664071716655 4.52363848356762e-09 mirMAP -0.749624948617895 0.00531805223011933 NA NA NA hsa-miR-19a-3p DLG2 1.26669687448473 0.000105972838514412 -3.9664071716655 4.52363848356762e-09 mirMAP -0.747697379490555 4.6898894923576e-07 NA NA NA hsa-miR-19b-3p DLG2 0.759818275708988 0.00652779573186786 -3.9664071716655 4.52363848356762e-09 mirMAP -0.653363371689165 0.000256609898410191 NA NA NA hsa-miR-20a-5p DLG2 1.4503375861709 5.7813456424762e-07 -3.9664071716655 4.52363848356762e-09 mirMAP -1.00115621366399 7.97565970214201e-10 NA NA NA hsa-miR-23a-3p DLG2 1.10685926969665 3.16223452471768e-08 -3.9664071716655 4.52363848356762e-09 MirTarget;miRNATAP -0.947034360622424 0.000111545893156947 NA NA NA hsa-miR-24-3p DLG2 1.08578167539644 6.18549359075268e-07 -3.9664071716655 4.52363848356762e-09 MirTarget -1.03710692058827 3.64073389585246e-06 NA NA NA hsa-miR-25-3p DLG2 1.00604871526544 0.000421838061147906 -3.9664071716655 4.52363848356762e-09 mirMAP -0.620294334865229 0.000360721931882143 NA NA NA hsa-miR-27a-5p DLG2 1.09051796355562 0.00189340505433517 -3.9664071716655 4.52363848356762e-09 miRNATAP -0.707620231994794 3.41143255397771e-07 NA NA NA hsa-miR-29b-1-5p DLG2 0.606560155953522 0.116355599574769 -3.9664071716655 4.52363848356762e-09 mirMAP -0.624499822686429 1.01776285570608e-06 NA NA NA hsa-miR-3127-5p DLG2 0.98677589413294 0.00734249049849 -3.9664071716655 4.52363848356762e-09 mirMAP -0.681086207295448 3.02385274045396e-07 NA NA NA hsa-miR-32-3p DLG2 0.583525764322974 0.11837203008551 -3.9664071716655 4.52363848356762e-09 mirMAP;miRNATAP -0.468150379622943 0.00195294844256034 NA NA NA hsa-miR-320a DLG2 0.593888711838028 0.011897419390526 -3.9664071716655 4.52363848356762e-09 PITA;miRanda;mirMAP;miRNATAP -0.716489321994237 0.000796488431760999 NA NA NA hsa-miR-320b DLG2 1.11183660885284 0.000497971211648503 -3.9664071716655 4.52363848356762e-09 PITA;miRanda;mirMAP;miRNATAP -0.894339696680734 2.87696756042165e-09 NA NA NA hsa-miR-335-3p DLG2 2.5197689063267 2.20084506976733e-09 -3.9664071716655 4.52363848356762e-09 mirMAP -0.655628498165334 2.76650298018332e-09 NA NA NA hsa-miR-335-5p DLG2 1.59953351087307 5.56170899867314e-05 -3.9664071716655 4.52363848356762e-09 miRNAWalker2_validate -0.367818374612905 0.00305966737932749 NA NA NA hsa-miR-33a-5p DLG2 0.407757858040717 0.321429014317207 -3.9664071716655 4.52363848356762e-09 mirMAP -0.422062661984927 0.000519932749341239 NA NA NA hsa-miR-33b-5p DLG2 0.267227362818466 0.614814331176942 -3.9664071716655 4.52363848356762e-09 mirMAP -0.367082373181987 0.00268370267761432 NA NA NA hsa-miR-3613-5p DLG2 1.11821523851438 0.000249706750761735 -3.9664071716655 4.52363848356762e-09 MirTarget;miRNATAP -0.794776754135449 6.27859180663013e-07 NA NA NA hsa-miR-378a-5p DLG2 -0.557166502179376 0.0344581590006454 -3.9664071716655 4.52363848356762e-09 mirMAP -0.648300653690081 0.00068952730722736 NA NA NA hsa-miR-3928-3p DLG2 1.3021682800308 0.00117241057113773 -3.9664071716655 4.52363848356762e-09 MirTarget -0.791533599733773 1.21687409037481e-08 NA NA NA hsa-miR-421 DLG2 1.80720854070385 1.59709651202848e-07 -3.9664071716655 4.52363848356762e-09 miRanda -0.616250678976983 9.69272489675768e-06 NA NA NA hsa-miR-429 DLG2 1.40182602301928 0.00900426780286475 -3.9664071716655 4.52363848356762e-09 miRNATAP -0.414181199238164 5.62298766039448e-06 NA NA NA hsa-miR-484 DLG2 0.71327898984355 0.00233605130771196 -3.9664071716655 4.52363848356762e-09 MirTarget;PITA -0.840405871160607 8.15824328430704e-05 NA NA NA hsa-miR-493-5p DLG2 0.962900723235399 0.00324541076496571 -3.9664071716655 4.52363848356762e-09 MirTarget;miRNATAP -0.423614477654825 0.00558562572957201 NA NA NA hsa-miR-505-5p DLG2 0.406607501325555 0.184328592339472 -3.9664071716655 4.52363848356762e-09 MirTarget;miRNATAP -0.467113116567432 0.00461876705734268 NA NA NA hsa-miR-548v DLG2 -0.156004387355895 0.708665170641638 -3.9664071716655 4.52363848356762e-09 miRNATAP -0.381086720811343 0.00263761385872539 NA NA NA hsa-miR-576-5p DLG2 0.625714137488957 0.0417100301848969 -3.9664071716655 4.52363848356762e-09 PITA;mirMAP -0.582903606850793 0.000344692065413248 NA NA NA hsa-miR-590-3p DLG2 1.11654983899947 0.000160782154924864 -3.9664071716655 4.52363848356762e-09 PITA;miRanda;mirMAP -0.657540585748158 7.85245191133259e-05 NA NA NA hsa-miR-590-5p DLG2 1.04171442093217 0.000272475544954865 -3.9664071716655 4.52363848356762e-09 PITA;miRanda -0.917836499780925 6.179961875737e-08 NA NA NA hsa-miR-592 DLG2 0.779567202789068 0.204498177014474 -3.9664071716655 4.52363848356762e-09 MirTarget;miRNATAP -0.328460671674174 0.000156821738711755 NA NA NA hsa-miR-615-3p DLG2 2.82967143704683 3.05118423223543e-05 -3.9664071716655 4.52363848356762e-09 miRanda -0.425450835826168 1.81738562149122e-05 NA NA NA hsa-miR-616-5p DLG2 0.834052908652744 0.0347835664029363 -3.9664071716655 4.52363848356762e-09 mirMAP -0.459292320663753 0.000348294360633922 NA NA NA hsa-miR-7-1-3p DLG2 0.709309110750947 0.0412301737463194 -3.9664071716655 4.52363848356762e-09 MirTarget -0.671077279459684 2.2391765451133e-06 NA NA NA hsa-miR-769-3p DLG2 1.38615307776278 4.57495734358166e-05 -3.9664071716655 4.52363848356762e-09 PITA;miRNATAP -0.57838807377475 0.000132306972355384 NA NA NA hsa-miR-769-5p DLG2 1.14821899306381 1.27143750879772e-06 -3.9664071716655 4.52363848356762e-09 miRNATAP -0.821947351492981 7.08429767978542e-05 NA NA NA hsa-miR-877-5p DLG2 2.17859965442336 1.03593450648516e-07 -3.9664071716655 4.52363848356762e-09 MirTarget -0.729586536111817 1.39750414722748e-10 NA NA NA hsa-miR-92a-3p DLG2 1.2209325870225 6.8757197708107e-06 -3.9664071716655 4.52363848356762e-09 mirMAP -1.14187385282105 5.86807917075453e-11 NA NA NA hsa-miR-92b-3p DLG2 1.33518446513417 1.45350885391576e-06 -3.9664071716655 4.52363848356762e-09 mirMAP -0.946761195695569 4.31802092943893e-08 NA NA NA hsa-miR-93-3p DLG2 1.88964231421793 1.80075645722786e-08 -3.9664071716655 4.52363848356762e-09 MirTarget;miRNATAP -0.803818602926837 9.44730432010193e-09 NA NA NA hsa-miR-940 DLG2 1.64406174271686 0.000690854900107004 -3.9664071716655 4.52363848356762e-09 MirTarget;PITA;miRNATAP -0.519029751796985 1.35364969483411e-05 NA NA NA hsa-miR-125b-2-3p DLG3 -0.236995187284862 0.63161659167442 -0.438626343940506 0.0730660395504451 mirMAP -0.120357685556199 0.000606664557050646 NA NA NA hsa-miR-218-5p DLG3 -0.987730614742492 0.0108295837207062 -0.438626343940506 0.0730660395504451 mirMAP -0.217387367009845 6.49610712151809e-07 NA NA NA hsa-miR-299-5p DLG3 -0.173288988251251 0.638938431622539 -0.438626343940506 0.0730660395504451 miRNATAP -0.157899136708195 0.000974074569790061 NA NA NA hsa-miR-342-3p DLG3 0.318119432680668 0.269150960124243 -0.438626343940506 0.0730660395504451 miRanda -0.179384332816548 0.00319706664551326 NA NA NA hsa-miR-455-3p DLG4 2.29532323519288 1.85675588946527e-07 -1.02622202336318 0.000434739141099316 MirTarget;PITA;miRNATAP -0.137089331024759 0.00295037233481015 NA NA NA hsa-miR-940 DLG4 1.64406174271686 0.000690854900107004 -1.02622202336318 0.000434739141099316 MirTarget;miRNATAP -0.132567142250822 0.00889419099345703 NA NA NA hsa-miR-150-5p DVL3 0.147461377429675 0.753719621305461 0.509159557836826 0.0191555023576877 MirTarget -0.136288717042111 2.80149026328444e-05 NA NA NA hsa-miR-29b-2-5p DVL3 -1.7015307882027 2.84239251703401e-10 0.509159557836826 0.0191555023576877 MirTarget -0.259672303335612 1.5757856884015e-06 NA NA NA hsa-miR-30d-3p DVL3 -0.545113326540761 0.0433733076874155 0.509159557836826 0.0191555023576877 MirTarget -0.208357364803817 0.00027782270884786 NA NA NA hsa-miR-338-3p DVL3 -0.959276231066179 0.0191473351014091 0.509159557836826 0.0191555023576877 miRanda -0.227023794827862 3.31810274034888e-10 NA NA NA hsa-miR-362-5p DVL3 -0.354508685915981 0.354912078595613 0.509159557836826 0.0191555023576877 PITA;TargetScan;miRNATAP -0.206660325578012 1.64767658075141e-07 NA NA NA hsa-miR-106b-5p FBXW11 1.70863907461894 2.04074794107142e-08 -0.835546010990401 9.47456240646085e-08 miRNATAP -0.152074606048823 2.17974755800729e-05 NA NA NA hsa-miR-130b-3p FBXW11 1.32714007211004 4.78676252285191e-05 -0.835546010990401 9.47456240646085e-08 MirTarget -0.113750376352462 0.000920026529446098 NA NA NA hsa-miR-16-5p FBXW11 1.00515772948091 5.33912942007619e-06 -0.835546010990401 9.47456240646085e-08 miRNAWalker2_validate -0.152266061171624 0.00296889370121248 NA NA NA hsa-miR-17-5p FBXW11 1.65862087862483 8.45603406215941e-08 -0.835546010990401 9.47456240646085e-08 TargetScan;miRNATAP -0.106920177014057 0.00279785926310923 NA NA NA hsa-miR-19a-3p FBXW11 1.26669687448473 0.000105972838514412 -0.835546010990401 9.47456240646085e-08 MirTarget -0.106821531441157 0.00190872520855486 NA NA NA hsa-miR-301a-3p FBXW11 1.44721900431161 6.35068481036652e-06 -0.835546010990401 9.47456240646085e-08 MirTarget -0.129970244210496 0.000176557053768814 NA NA NA hsa-miR-320a FBXW11 0.593888711838028 0.011897419390526 -0.835546010990401 9.47456240646085e-08 PITA;miRanda -0.199629888465189 3.42693811438199e-05 NA NA NA hsa-miR-320b FBXW11 1.11183660885284 0.000497971211648503 -0.835546010990401 9.47456240646085e-08 PITA;miRanda -0.150183139627122 1.74647723246979e-05 NA NA NA hsa-miR-330-3p FBXW11 0.798460296022179 0.00746538156533435 -0.835546010990401 9.47456240646085e-08 MirTarget;PITA;miRNATAP -0.111231997158208 0.00359341214785333 NA NA NA hsa-miR-331-3p FBXW11 1.04880525429426 9.99995355989124e-05 -0.835546010990401 9.47456240646085e-08 miRNATAP -0.169251803464536 4.62834519702063e-05 NA NA NA hsa-miR-421 FBXW11 1.80720854070385 1.59709651202848e-07 -0.835546010990401 9.47456240646085e-08 miRanda;mirMAP -0.113434651458546 0.000383574219532576 NA NA NA hsa-miR-454-3p FBXW11 0.625199142970745 0.0134890997402741 -0.835546010990401 9.47456240646085e-08 MirTarget -0.120357711624832 0.00807502583987832 NA NA NA hsa-miR-505-3p FBXW11 0.82660100642669 0.00111666333288398 -0.835546010990401 9.47456240646085e-08 mirMAP -0.159993075743164 0.000348128424353584 NA NA NA hsa-miR-590-3p FBXW11 1.11654983899947 0.000160782154924864 -0.835546010990401 9.47456240646085e-08 mirMAP -0.122147676944732 0.00134771809078803 NA NA NA hsa-miR-93-5p FBXW11 1.7515174434778 1.59386482413883e-08 -0.835546010990401 9.47456240646085e-08 miRNATAP -0.130763658591555 0.000218066405911031 NA NA NA hsa-miR-126-5p FGF1 0.41765430251855 0.0753161203651532 -0.160234396361762 0.733972871379557 mirMAP -0.59094523029959 3.50264864833946e-05 NA NA NA hsa-miR-16-1-3p FGF1 1.43227522002564 3.70920454953168e-08 -0.160234396361762 0.733972871379557 mirMAP -0.415017127195873 0.000891606226757529 NA NA NA hsa-miR-186-5p FGF1 0.149964130725901 0.434709542998771 -0.160234396361762 0.733972871379557 mirMAP -0.802927092384163 5.33712623622096e-06 NA NA NA hsa-miR-18a-5p FGF1 2.20211504140984 1.78678887916334e-09 -0.160234396361762 0.733972871379557 MirTarget -0.427564859159038 6.45322365688328e-07 NA NA NA hsa-miR-222-5p FGF1 1.87968474330782 1.11743009485711e-06 -0.160234396361762 0.733972871379557 MirTarget -0.328069555060374 8.83297301332189e-05 NA NA NA hsa-miR-26b-3p FGF1 -0.0103961389461977 0.965770899625511 -0.160234396361762 0.733972871379557 MirTarget -0.614591765464955 8.91145535430066e-06 NA NA NA hsa-miR-29a-5p FGF1 0.585084040404152 0.023014129158495 -0.160234396361762 0.733972871379557 mirMAP -0.604881337368894 2.58167935202965e-06 NA NA NA hsa-miR-320a FGF1 0.593888711838028 0.011897419390526 -0.160234396361762 0.733972871379557 miRanda -0.386072945122806 0.00701900096114403 NA NA NA hsa-miR-320b FGF1 1.11183660885284 0.000497971211648503 -0.160234396361762 0.733972871379557 miRanda -0.368173004233106 0.000368398615653149 NA NA NA hsa-miR-326 FGF1 -0.429748586406214 0.2629894124021 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.385294600510288 9.62075997895276e-06 NA NA NA hsa-miR-330-5p FGF1 0.488365986827708 0.0512207630808233 -0.160234396361762 0.733972871379557 miRanda;miRNATAP -0.490680892266321 0.000251789498451697 NA NA NA hsa-miR-429 FGF1 1.40182602301928 0.00900426780286475 -0.160234396361762 0.733972871379557 miRNATAP -0.323262102446773 7.92592247701929e-08 NA NA NA hsa-miR-484 FGF1 0.71327898984355 0.00233605130771196 -0.160234396361762 0.733972871379557 MirTarget;PITA;miRNATAP -0.408471643921956 0.00445789085377771 NA NA NA hsa-miR-532-3p FGF1 0.552364451472481 0.0975490365586023 -0.160234396361762 0.733972871379557 miRNATAP -0.744864947914853 2.30927245315596e-15 NA NA NA hsa-miR-550a-5p FGF1 2.27360629906903 2.14504977831873e-07 -0.160234396361762 0.733972871379557 MirTarget -0.412011719251591 1.06463288268876e-08 NA NA NA hsa-miR-590-5p FGF1 1.04171442093217 0.000272475544954865 -0.160234396361762 0.733972871379557 MirTarget;miRanda;miRNATAP -0.411316166846436 0.00036918107931291 NA NA NA hsa-miR-625-5p FGF1 0.537211086526376 0.203801009380384 -0.160234396361762 0.733972871379557 MirTarget -0.597908728237488 7.37909450819918e-16 NA NA NA hsa-miR-629-5p FGF1 1.06377074768516 0.000536624707722274 -0.160234396361762 0.733972871379557 MirTarget -0.349957209459157 0.00121021361741485 NA NA NA hsa-miR-7-5p FGF1 1.63575693499363 0.0124424214624534 -0.160234396361762 0.733972871379557 miRNAWalker2_validate -0.334571255736156 4.63756500683767e-11 NA NA NA hsa-miR-34c-5p FRMD1 2.20632574870337 0.000379662996168678 -5.65218896321438 2.08172476821411e-08 miRanda -0.494202603017993 2.62751954785882e-05 NA NA NA hsa-miR-106b-5p FRMD6 1.70863907461894 2.04074794107142e-08 0.28504332264727 0.631044375781935 MirTarget;miRNATAP -0.403087615561131 0.00261574583775533 NA NA NA hsa-miR-130b-3p FRMD6 1.32714007211004 4.78676252285191e-05 0.28504332264727 0.631044375781935 MirTarget -0.333225546143321 0.00899331171570201 NA NA NA hsa-miR-140-3p FRMD6 -0.296251775392129 0.127539826012144 0.28504332264727 0.631044375781935 PITA -1.12103443845802 2.42558159061809e-07 NA NA NA hsa-miR-140-5p FRMD6 0.208193069681326 0.303002433893804 0.28504332264727 0.631044375781935 miRanda -0.735184591203732 0.000544684937229786 NA NA NA hsa-miR-141-3p FRMD6 1.45548825076434 0.00115958850961764 0.28504332264727 0.631044375781935 MirTarget;TargetScan;miRNATAP -0.270249063708626 0.00365277724705743 NA NA NA hsa-miR-146a-5p FRMD6 1.82051649415508 2.03651725047679e-05 0.28504332264727 0.631044375781935 MirTarget -0.446440594894597 2.56989964770033e-06 NA NA NA hsa-miR-148a-5p FRMD6 -0.69329616490858 0.0793012233740369 0.28504332264727 0.631044375781935 miRNATAP -0.654111193823419 1.62389711189102e-10 NA NA NA hsa-miR-17-5p FRMD6 1.65862087862483 8.45603406215941e-08 0.28504332264727 0.631044375781935 MirTarget;TargetScan;miRNATAP -0.344266500786783 0.00941999636206365 NA NA NA hsa-miR-200a-3p FRMD6 0.717826667295984 0.193912116506827 0.28504332264727 0.631044375781935 MirTarget;miRNATAP -0.496765643638767 7.0932291038114e-12 NA NA NA hsa-miR-200b-3p FRMD6 0.974577911407732 0.0595020056914543 0.28504332264727 0.631044375781935 TargetScan -0.52639346047373 1.00374082321946e-11 NA NA NA hsa-miR-200c-3p FRMD6 1.28185685499076 0.00369777635539177 0.28504332264727 0.631044375781935 miRNATAP -0.2878931184861 0.00231580266695241 NA NA NA hsa-miR-20a-5p FRMD6 1.4503375861709 5.7813456424762e-07 0.28504332264727 0.631044375781935 MirTarget;miRNATAP -0.402130748498542 0.00466993803242713 NA NA NA hsa-miR-29b-1-5p FRMD6 0.606560155953522 0.116355599574769 0.28504332264727 0.631044375781935 MirTarget -0.510517542725409 2.04982117365261e-06 NA NA NA hsa-miR-29b-2-5p FRMD6 -1.7015307882027 2.84239251703401e-10 0.28504332264727 0.631044375781935 MirTarget -0.797481905585587 4.94748252333771e-08 NA NA NA hsa-miR-30b-5p FRMD6 -0.430720743745757 0.0593564057320791 0.28504332264727 0.631044375781935 MirTarget -0.971996959076885 9.91396126978704e-08 NA NA NA hsa-miR-30c-5p FRMD6 -0.983130268805942 4.60419218706127e-05 0.28504332264727 0.631044375781935 MirTarget;miRNATAP -0.467227826911747 0.00726244036325035 NA NA NA hsa-miR-30d-5p FRMD6 -0.5492586056147 0.0140125082460125 0.28504332264727 0.631044375781935 MirTarget;miRNATAP -1.25008781918557 5.82567913217688e-12 NA NA NA hsa-miR-320a FRMD6 0.593888711838028 0.011897419390526 0.28504332264727 0.631044375781935 miRanda -0.537073287746816 0.00284838212424962 NA NA NA hsa-miR-320b FRMD6 1.11183660885284 0.000497971211648503 0.28504332264727 0.631044375781935 miRanda -0.44834292384627 0.000582704897315604 NA NA NA hsa-miR-335-3p FRMD6 2.5197689063267 2.20084506976733e-09 0.28504332264727 0.631044375781935 mirMAP -0.437825162114928 3.42013955653591e-06 NA NA NA hsa-miR-362-3p FRMD6 -0.0349414695893027 0.913780708043777 0.28504332264727 0.631044375781935 miRanda;miRNATAP -0.70742672841527 3.47431338730892e-08 NA NA NA hsa-miR-375 FRMD6 -2.94506033785642 0.00570147601654791 0.28504332264727 0.631044375781935 miRanda -0.354345505496858 1.74144735170083e-24 NA NA NA hsa-miR-429 FRMD6 1.40182602301928 0.00900426780286475 0.28504332264727 0.631044375781935 miRanda;miRNATAP -0.466852364552163 4.55101366896172e-10 NA NA NA hsa-miR-501-5p FRMD6 0.266919328110625 0.454779001968586 0.28504332264727 0.631044375781935 MirTarget;PITA;miRNATAP -0.80516727174931 7.417354680978e-13 NA NA NA hsa-miR-550a-3p FRMD6 2.05849884025997 7.99642185793604e-07 0.28504332264727 0.631044375781935 miRNATAP -0.45008545147948 2.80523642512162e-05 NA NA NA hsa-miR-7-1-3p FRMD6 0.709309110750947 0.0412301737463194 0.28504332264727 0.631044375781935 MirTarget -1.07985818399328 2.29077567968175e-23 NA NA NA hsa-miR-146a-5p FZD1 1.82051649415508 2.03651725047679e-05 -0.0116014459919223 0.971055441927162 MirTarget -0.135839950014759 0.00903670338435189 NA NA NA hsa-miR-148b-5p FZD1 1.04409494910362 0.00195860954157389 -0.0116014459919223 0.971055441927162 MirTarget -0.215530195063489 0.00121026064233929 NA NA NA hsa-miR-186-5p FZD1 0.149964130725901 0.434709542998771 -0.0116014459919223 0.971055441927162 mirMAP -0.411244271827282 0.000665835685952783 NA NA NA hsa-miR-192-5p FZD1 0.0809146624034405 0.941057093528709 -0.0116014459919223 0.971055441927162 miRNAWalker2_validate -0.172369859573993 4.18747109183886e-20 NA NA NA hsa-miR-200a-5p FZD1 1.50371809098978 0.00263602434344863 -0.0116014459919223 0.971055441927162 MirTarget -0.144491650796421 0.00122428342438984 NA NA NA hsa-miR-200b-5p FZD1 0.969871521250413 0.0530500454130183 -0.0116014459919223 0.971055441927162 MirTarget -0.202677886725161 1.34972339604881e-05 NA NA NA hsa-miR-215-5p FZD1 0.715250240418615 0.573784317311889 -0.0116014459919223 0.971055441927162 miRNAWalker2_validate -0.139131230093837 2.02918938954419e-17 NA NA NA hsa-miR-29a-3p FZD1 -0.113012156986374 0.615005009685815 -0.0116014459919223 0.971055441927162 mirMAP -0.510037402232287 3.89366800198649e-07 NA NA NA hsa-miR-29b-3p FZD1 -0.230693226193598 0.367461626035234 -0.0116014459919223 0.971055441927162 mirMAP -0.51020925859091 3.99515814256682e-09 NA NA NA hsa-miR-335-5p FZD1 1.59953351087307 5.56170899867314e-05 -0.0116014459919223 0.971055441927162 miRNAWalker2_validate -0.260045141228304 2.37414243918884e-06 NA NA NA hsa-miR-577 FZD1 0.911619788986754 0.2256062124148 -0.0116014459919223 0.971055441927162 MirTarget;PITA -0.188163372200914 1.81148790398054e-10 NA NA NA hsa-miR-140-3p FZD10 -0.296251775392129 0.127539826012144 2.15012616580991 0.00645756967653537 miRNATAP -1.24408944145646 2.45341632415967e-05 NA NA NA hsa-let-7b-3p FZD3 0.21838629112113 0.296038413622566 -0.45516039703683 0.17294926659228 MirTarget;miRNATAP -0.34639344756851 0.00281774006796447 NA NA NA hsa-let-7b-5p FZD3 0.0582902155815681 0.781400138984745 -0.45516039703683 0.17294926659228 MirTarget;miRNATAP -0.392906234115836 0.000640812668229522 NA NA NA hsa-let-7a-3p FZD4 0.503048155002889 0.0411145454335299 -1.77378368856995 2.74551233886176e-07 mirMAP -0.474247678798706 3.33238789043121e-06 NA NA NA hsa-let-7b-3p FZD4 0.21838629112113 0.296038413622566 -1.77378368856995 2.74551233886176e-07 mirMAP -0.47368533212311 0.00011328754774705 NA NA NA hsa-let-7b-5p FZD4 0.0582902155815681 0.781400138984745 -1.77378368856995 2.74551233886176e-07 MirTarget;miRNATAP -0.562188615150997 3.49936892267095e-06 NA NA NA hsa-let-7d-5p FZD4 0.981733854788227 7.26366577706469e-07 -1.77378368856995 2.74551233886176e-07 MirTarget;miRNATAP -0.388681677113273 0.00216275568247124 NA NA NA hsa-let-7f-1-3p FZD4 1.28704406797397 1.17954701106157e-06 -1.77378368856995 2.74551233886176e-07 mirMAP -0.340741904264114 0.000257422092493228 NA NA NA hsa-miR-106b-5p FZD4 1.70863907461894 2.04074794107142e-08 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.289869427589178 0.000288963624806192 NA NA NA hsa-miR-130b-3p FZD4 1.32714007211004 4.78676252285191e-05 -1.77378368856995 2.74551233886176e-07 mirMAP -0.260605530086942 0.0006135677753591 NA NA NA hsa-miR-141-3p FZD4 1.45548825076434 0.00115958850961764 -1.77378368856995 2.74551233886176e-07 TargetScan -0.210841555422078 0.000140167907540657 NA NA NA hsa-miR-15a-5p FZD4 1.03783090449383 7.40334108980898e-07 -1.77378368856995 2.74551233886176e-07 MirTarget -0.354643508095702 0.00300348038379071 NA NA NA hsa-miR-15b-5p FZD4 1.62046407540723 5.42152621571078e-09 -1.77378368856995 2.74551233886176e-07 MirTarget -0.446742497861283 2.11765259839447e-07 NA NA NA hsa-miR-16-5p FZD4 1.00515772948091 5.33912942007619e-06 -1.77378368856995 2.74551233886176e-07 MirTarget -0.494354182267088 1.04659513687156e-05 NA NA NA hsa-miR-17-3p FZD4 1.31126744284937 3.24768335024185e-07 -1.77378368856995 2.74551233886176e-07 MirTarget -0.419424101812676 1.06894379933304e-05 NA NA NA hsa-miR-17-5p FZD4 1.65862087862483 8.45603406215941e-08 -1.77378368856995 2.74551233886176e-07 TargetScan -0.349046752683359 8.16481217626579e-06 NA NA NA hsa-miR-185-5p FZD4 1.14351510556643 1.07346945085714e-08 -1.77378368856995 2.74551233886176e-07 MirTarget -0.456126768213788 0.000221896647042113 NA NA NA hsa-miR-200c-3p FZD4 1.28185685499076 0.00369777635539177 -1.77378368856995 2.74551233886176e-07 mirMAP -0.216735427540092 0.000118856419940465 NA NA NA hsa-miR-20a-5p FZD4 1.4503375861709 5.7813456424762e-07 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.314583239619099 0.000203283824727368 NA NA NA hsa-miR-21-5p FZD4 1.75445050487988 2.41825549682022e-23 -1.77378368856995 2.74551233886176e-07 mirMAP -0.415162350810554 0.00145285830098696 NA NA NA hsa-miR-219a-5p FZD4 0.605535434887599 0.0854495887591817 -1.77378368856995 2.74551233886176e-07 MirTarget -0.324301918558707 4.9641925216081e-06 NA NA NA hsa-miR-224-3p FZD4 1.52422171450716 0.00650463542340912 -1.77378368856995 2.74551233886176e-07 MirTarget -0.347768541662987 4.82908161841418e-14 NA NA NA hsa-miR-24-3p FZD4 1.08578167539644 6.18549359075268e-07 -1.77378368856995 2.74551233886176e-07 miRNAWalker2_validate -0.83159012627226 1.1095069389975e-14 NA NA NA hsa-miR-27a-3p FZD4 1.29886998470345 2.68986118553486e-08 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.78094225554907 2.95450399523203e-15 NA NA NA hsa-miR-27b-3p FZD4 0.0836323965901755 0.725273923274 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.577538131718514 3.9498574714407e-08 NA NA NA hsa-miR-301a-3p FZD4 1.44721900431161 6.35068481036652e-06 -1.77378368856995 2.74551233886176e-07 mirMAP -0.284701237288523 0.00021447919902336 NA NA NA hsa-miR-3065-5p FZD4 -0.241623656423063 0.633116553078159 -1.77378368856995 2.74551233886176e-07 mirMAP -0.187421050913851 0.000232044632407712 NA NA NA hsa-miR-324-3p FZD4 1.04940352369965 0.000387716796520961 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.488652210043455 2.62272804050291e-09 NA NA NA hsa-miR-33a-3p FZD4 0.347011402017138 0.321709379745392 -1.77378368856995 2.74551233886176e-07 mirMAP -0.197667870436447 0.00980885311957539 NA NA NA hsa-miR-361-5p FZD4 0.407725414130987 0.0181260969156347 -1.77378368856995 2.74551233886176e-07 mirMAP -0.48171748824972 0.00138173287978507 NA NA NA hsa-miR-452-5p FZD4 2.08756506185889 0.000258095769002813 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.323617786446656 1.56647425013332e-15 NA NA NA hsa-miR-455-3p FZD4 2.29532323519288 1.85675588946527e-07 -1.77378368856995 2.74551233886176e-07 mirMAP -0.372702840664708 1.63855256160138e-12 NA NA NA hsa-miR-484 FZD4 0.71327898984355 0.00233605130771196 -1.77378368856995 2.74551233886176e-07 PITA -0.302365013961778 0.0053823855948778 NA NA NA hsa-miR-590-5p FZD4 1.04171442093217 0.000272475544954865 -1.77378368856995 2.74551233886176e-07 mirMAP -0.335626531177855 0.000116017486990527 NA NA NA hsa-miR-629-3p FZD4 1.40326397107309 9.7803063526732e-05 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.241190045329505 0.000462844667701511 NA NA NA hsa-miR-708-5p FZD4 1.41830449251856 0.0109647946476309 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.286816127716948 2.46722951088968e-11 NA NA NA hsa-miR-92a-3p FZD4 1.2209325870225 6.8757197708107e-06 -1.77378368856995 2.74551233886176e-07 mirMAP -0.474403610852125 1.19152955970364e-07 NA NA NA hsa-miR-92b-3p FZD4 1.33518446513417 1.45350885391576e-06 -1.77378368856995 2.74551233886176e-07 mirMAP -0.253958578711496 0.00460825285657811 NA NA NA hsa-miR-940 FZD4 1.64406174271686 0.000690854900107004 -1.77378368856995 2.74551233886176e-07 miRNATAP -0.313038908254503 1.41566608326448e-07 NA NA NA hsa-let-7a-3p FZD5 0.503048155002889 0.0411145454335299 -0.562388840536974 0.201609832561101 miRNATAP -0.433792419416311 0.000694523466406666 NA NA NA hsa-let-7b-3p FZD5 0.21838629112113 0.296038413622566 -0.562388840536974 0.201609832561101 miRNATAP -0.463019683690644 0.00247606952247574 NA NA NA hsa-miR-100-5p FZD5 -0.909635282943505 0.0262703445792608 -0.562388840536974 0.201609832561101 MirTarget;miRNATAP -0.442815032045466 1.75855596199589e-09 NA NA NA hsa-miR-149-5p FZD5 0.706277554734069 0.296848731347677 -0.562388840536974 0.201609832561101 miRNAWalker2_validate;miRNATAP -0.405734333464752 9.93854445215021e-23 NA NA NA hsa-miR-181a-2-3p FZD5 0.901732254836667 0.000830304681396734 -0.562388840536974 0.201609832561101 MirTarget -0.402233455281732 0.000481739180635693 NA NA NA hsa-miR-23a-3p FZD5 1.10685926969665 3.16223452471768e-08 -0.562388840536974 0.201609832561101 miRNATAP -1.06531099929059 2.63798793406044e-13 NA NA NA hsa-miR-23b-3p FZD5 -0.286465516491361 0.18664668472995 -0.562388840536974 0.201609832561101 miRNATAP -0.713070253857732 7.5090190950656e-07 NA NA NA hsa-miR-24-3p FZD5 1.08578167539644 6.18549359075268e-07 -0.562388840536974 0.201609832561101 miRNAWalker2_validate;miRNATAP -0.765814625048373 2.94704370085362e-08 NA NA NA hsa-miR-296-5p FZD5 0.932146077883618 0.0602370559607489 -0.562388840536974 0.201609832561101 MirTarget -0.351467930166965 3.53443757513299e-08 NA NA NA hsa-miR-342-3p FZD5 0.318119432680668 0.269150960124243 -0.562388840536974 0.201609832561101 PITA -0.464529767459804 1.79328059063245e-05 NA NA NA hsa-miR-369-3p FZD5 0.32261175629684 0.3589927609891 -0.562388840536974 0.201609832561101 MirTarget;PITA;miRNATAP -0.307766649378363 0.00054444489201294 NA NA NA hsa-miR-493-5p FZD5 0.962900723235399 0.00324541076496571 -0.562388840536974 0.201609832561101 mirMAP -0.25962315522555 0.00651784425476355 NA NA NA hsa-miR-744-3p FZD5 1.40439584998788 0.000973603203532439 -0.562388840536974 0.201609832561101 MirTarget -0.258155245661644 0.000368319948308627 NA NA NA hsa-miR-9-5p FZD5 -0.195328736653048 0.761470692992178 -0.562388840536974 0.201609832561101 MirTarget -0.21435856482923 7.52961383229045e-06 NA NA NA hsa-miR-99a-5p FZD5 -1.06045199862251 0.0178432627965381 -0.562388840536974 0.201609832561101 MirTarget;miRNATAP -0.334119626257152 9.57778568333215e-07 NA NA NA hsa-miR-99b-5p FZD5 -0.13479816934921 0.559985680534109 -0.562388840536974 0.201609832561101 MirTarget;miRNATAP -0.424207876119648 0.00205382932621701 NA NA NA hsa-miR-101-3p FZD6 -0.451263906815861 0.0283387250173031 1.01751364030186 0.00533039339420292 miRNAWalker2_validate;MirTarget -0.53697704967212 2.65711094950103e-05 NA NA NA hsa-miR-107 FZD6 0.904627575346218 4.67936495073904e-05 1.01751364030186 0.00533039339420292 miRanda -0.475524015361518 4.29206537614299e-05 NA NA NA hsa-miR-126-5p FZD6 0.41765430251855 0.0753161203651532 1.01751364030186 0.00533039339420292 mirMAP;miRNATAP -0.606626907557921 3.20982636253826e-08 NA NA NA hsa-miR-139-5p FZD6 -1.83374360776637 1.22019901002824e-09 1.01751364030186 0.00533039339420292 miRanda -0.36562942687272 8.66732417133379e-06 NA NA NA hsa-miR-140-5p FZD6 0.208193069681326 0.303002433893804 1.01751364030186 0.00533039339420292 MirTarget;miRanda -0.769857163635617 1.75073967855856e-09 NA NA NA hsa-miR-194-5p FZD6 -0.127742909829168 0.906065815804667 1.01751364030186 0.00533039339420292 MirTarget -0.253140885039263 2.02279040994074e-36 NA NA NA hsa-miR-32-3p FZD6 0.583525764322974 0.11837203008551 1.01751364030186 0.00533039339420292 MirTarget -0.223693475618696 0.00459891488965885 NA NA NA hsa-miR-186-5p FZD7 0.149964130725901 0.434709542998771 0.284851674184938 0.539480317061435 mirMAP -0.518078952897405 0.00332812334924414 NA NA NA hsa-miR-192-5p FZD7 0.0809146624034405 0.941057093528709 0.284851674184938 0.539480317061435 miRNAWalker2_validate -0.207759186039428 2.32686660265092e-13 NA NA NA hsa-miR-215-5p FZD7 0.715250240418615 0.573784317311889 0.284851674184938 0.539480317061435 miRNAWalker2_validate -0.195646832216478 3.59863230075929e-16 NA NA NA hsa-miR-330-3p FZD7 0.798460296022179 0.00746538156533435 0.284851674184938 0.539480317061435 mirMAP -0.31209659173216 0.00472733122599548 NA NA NA hsa-miR-338-3p FZD7 -0.959276231066179 0.0191473351014091 0.284851674184938 0.539480317061435 miRanda -0.340459248478567 1.68277235624925e-05 NA NA NA hsa-miR-338-5p FZD7 -1.19659203838734 0.0100316010080496 0.284851674184938 0.539480317061435 MirTarget;PITA;miRNATAP -0.26429936691703 0.000155278124599023 NA NA NA hsa-miR-429 FZD7 1.40182602301928 0.00900426780286475 0.284851674184938 0.539480317061435 miRanda;miRNATAP -0.226991845972726 0.000172212993823567 NA NA NA hsa-miR-532-5p FZD7 0.313080805824184 0.252248939356301 0.284851674184938 0.539480317061435 PITA;miRNATAP -0.579824496143873 1.19502443213643e-06 NA NA NA hsa-miR-324-5p FZD8 1.08820215809537 3.11674414561836e-05 -1.68511420434562 6.09052149182579e-05 miRanda -0.335790881363403 0.00361619739529918 NA NA NA hsa-miR-335-5p FZD8 1.59953351087307 5.56170899867314e-05 -1.68511420434562 6.09052149182579e-05 miRNAWalker2_validate -0.246449216460617 0.00103891160966273 NA NA NA hsa-miR-590-3p FZD8 1.11654983899947 0.000160782154924864 -1.68511420434562 6.09052149182579e-05 miRanda -0.312768041823135 0.00212552048468477 NA NA NA hsa-miR-192-5p FZD9 0.0809146624034405 0.941057093528709 0.162760512039573 0.808745001206126 miRNATAP -0.319464660859328 4.02378857544127e-15 NA NA NA hsa-let-7d-5p GDF6 0.981733854788227 7.26366577706469e-07 -1.50226649857312 0.0617935240115429 MirTarget;miRNATAP -1.22426011580771 1.63766393927651e-05 NA NA NA hsa-let-7f-5p GDF6 0.634633924115866 0.0344982923411787 -1.50226649857312 0.0617935240115429 MirTarget;miRNATAP -0.519741168770107 0.00680213509981762 NA NA NA hsa-let-7g-5p GDF6 0.325297685027927 0.241142963826631 -1.50226649857312 0.0617935240115429 MirTarget;miRNATAP -0.800411952336345 0.000110173184916804 NA NA NA hsa-miR-141-3p GDF6 1.45548825076434 0.00115958850961764 -1.50226649857312 0.0617935240115429 TargetScan -0.619218237491826 5.82875861592422e-07 NA NA NA hsa-miR-141-5p GDF6 2.07543489990205 6.42575039070838e-06 -1.50226649857312 0.0617935240115429 mirMAP -0.538354603335814 7.13625329018952e-06 NA NA NA hsa-miR-148a-3p GDF6 -1.53721533763578 3.55533747293117e-05 -1.50226649857312 0.0617935240115429 miRNATAP -0.423134658553541 0.00530963570975077 NA NA NA hsa-miR-200b-3p GDF6 0.974577911407732 0.0595020056914543 -1.50226649857312 0.0617935240115429 TargetScan -0.71679695823568 9.89724060005709e-12 NA NA NA hsa-miR-23a-5p GDF6 1.31066638832406 0.00315098553367529 -1.50226649857312 0.0617935240115429 miRNATAP -0.526193298215953 3.58745116300689e-05 NA NA NA hsa-miR-23b-5p GDF6 0.608950043767916 0.0486466728330363 -1.50226649857312 0.0617935240115429 miRNATAP -0.497321187610074 0.0098502993561916 NA NA NA hsa-miR-30d-3p GDF6 -0.545113326540761 0.0433733076874155 -1.50226649857312 0.0617935240115429 miRNATAP -1.0285663479297 9.5395980957665e-07 NA NA NA hsa-miR-339-5p GDF6 0.770566566962108 0.00816529093411862 -1.50226649857312 0.0617935240115429 miRanda -0.59453219893194 0.00253821824669395 NA NA NA hsa-miR-429 GDF6 1.40182602301928 0.00900426780286475 -1.50226649857312 0.0617935240115429 PITA;miRanda;miRNATAP -0.674003143381659 2.8092491832123e-11 NA NA NA hsa-miR-532-3p GDF6 0.552364451472481 0.0975490365586023 -1.50226649857312 0.0617935240115429 PITA;miRNATAP -1.25902810386881 6.69851302144188e-15 NA NA NA hsa-miR-590-3p GDF6 1.11654983899947 0.000160782154924864 -1.50226649857312 0.0617935240115429 miRanda;mirMAP -0.588225253347122 0.00218185755843967 NA NA NA hsa-miR-616-5p GDF6 0.834052908652744 0.0347835664029363 -1.50226649857312 0.0617935240115429 mirMAP -0.492417039353738 0.000820355878111668 NA NA NA hsa-miR-197-3p GDF7 0.888854270009261 0.000195183808214449 -3.00957173720936 8.1075148817854e-06 miRNAWalker2_validate -0.625013865090123 0.00234032247180653 NA NA NA hsa-miR-141-3p GLI2 1.45548825076434 0.00115958850961764 0.393562966087483 0.554095983835935 MirTarget -0.284477098129653 0.00642082090247191 NA NA NA hsa-miR-142-3p GLI2 1.32364054836498 0.0001537753622128 0.393562966087483 0.554095983835935 miRanda -0.384327751625704 0.00396973967779298 NA NA NA hsa-miR-200a-3p GLI2 0.717826667295984 0.193912116506827 0.393562966087483 0.554095983835935 MirTarget -0.230958640700393 0.00686450315212077 NA NA NA hsa-miR-30b-5p GLI2 -0.430720743745757 0.0593564057320791 0.393562966087483 0.554095983835935 MirTarget -0.81503517614379 8.87659237180645e-05 NA NA NA hsa-miR-30d-5p GLI2 -0.5492586056147 0.0140125082460125 0.393562966087483 0.554095983835935 MirTarget -0.793256833747898 0.000187836412572722 NA NA NA hsa-miR-326 GLI2 -0.429748586406214 0.2629894124021 0.393562966087483 0.554095983835935 MirTarget -0.416907875305517 0.000794274515655006 NA NA NA hsa-miR-330-5p GLI2 0.488365986827708 0.0512207630808233 0.393562966087483 0.554095983835935 MirTarget -0.793059836050051 2.52459617734094e-05 NA NA NA hsa-miR-501-3p GLI2 0.731876211669996 0.0270421347018303 0.393562966087483 0.554095983835935 MirTarget;miRNATAP -0.418954567800522 0.00334081482036899 NA NA NA hsa-miR-502-3p GLI2 -0.16442685491191 0.557471818466728 0.393562966087483 0.554095983835935 MirTarget;miRNATAP -0.617139222325861 0.000267381335574409 NA NA NA hsa-miR-577 GLI2 0.911619788986754 0.2256062124148 0.393562966087483 0.554095983835935 MirTarget -0.270803896981245 1.90148523174514e-05 NA NA NA hsa-miR-101-3p GSK3B -0.451263906815861 0.0283387250173031 0.173686703054757 0.358761637442374 miRNATAP -0.309746385838821 1.76772309214892e-06 NA NA NA hsa-miR-212-3p GSK3B 0.960352937108106 0.00133449812322732 0.173686703054757 0.358761637442374 mirMAP;miRNATAP -0.157580688036431 0.000373666664591505 NA NA NA hsa-miR-26a-5p GSK3B -0.384110714440647 0.0442498636014044 0.173686703054757 0.358761637442374 miRNAWalker2_validate;miRNATAP -0.297404702806196 2.62046086511681e-05 NA NA NA hsa-miR-26b-5p GSK3B -0.301646326928219 0.160081421968103 0.173686703054757 0.358761637442374 miRNATAP -0.202543608293146 0.00135911800763895 NA NA NA hsa-miR-29a-3p GSK3B -0.113012156986374 0.615005009685815 0.173686703054757 0.358761637442374 miRNATAP -0.237953626141529 7.3117565138463e-05 NA NA NA hsa-miR-29b-3p GSK3B -0.230693226193598 0.367461626035234 0.173686703054757 0.358761637442374 miRTarBase;miRNATAP -0.139976205675035 0.00818133109022919 NA NA NA hsa-miR-29c-3p GSK3B -1.62454036584589 5.38376515586029e-07 0.173686703054757 0.358761637442374 miRNATAP -0.149008148419369 0.000186841384822779 NA NA NA hsa-miR-30d-3p GSK3B -0.545113326540761 0.0433733076874155 0.173686703054757 0.358761637442374 miRNATAP -0.134805668946892 0.00688448679166308 NA NA NA hsa-miR-340-5p GSK3B -0.164941927483643 0.529910509321278 0.173686703054757 0.358761637442374 mirMAP -0.184933292640156 0.000302021889990012 NA NA NA hsa-miR-195-3p ID1 -1.34779269408059 2.01619826639376e-05 0.181950554077901 0.622313609488591 MirTarget;miRNATAP -0.247547389448631 0.00251635305333636 NA NA NA hsa-miR-27a-3p ID2 1.29886998470345 2.68986118553486e-08 -0.123138990002922 0.714724898249103 MirTarget;miRNATAP -0.522251676846649 8.1966660483647e-08 NA NA NA hsa-miR-27b-3p ID2 0.0836323965901755 0.725273923274 -0.123138990002922 0.714724898249103 MirTarget;miRNATAP -0.29078729587596 0.00439025834737395 NA NA NA hsa-miR-455-3p ID2 2.29532323519288 1.85675588946527e-07 -0.123138990002922 0.714724898249103 MirTarget;PITA;miRNATAP -0.157912726636148 0.00260885316985629 NA NA NA hsa-miR-429 ITGB2 1.40182602301928 0.00900426780286475 1.10134147300749 0.00957503258821244 miRanda -0.240008372850882 1.49586798998692e-05 NA NA NA hsa-miR-320b LATS1 1.11183660885284 0.000497971211648503 -0.0862039901505804 0.620723919494016 miRanda;miRNATAP -0.115175217560579 0.00246680352452432 NA NA NA hsa-miR-103a-3p LATS2 0.840525139266028 5.83536475789158e-07 -0.48650966132387 0.0315328097394332 miRNATAP -0.474515237133701 4.45155888187414e-07 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-107 LATS2 0.904627575346218 4.67936495073904e-05 -0.48650966132387 0.0315328097394332 PITA;miRanda;miRNATAP -0.255913860398883 0.000367602344140393 NA NA NA hsa-miR-130b-5p LATS2 0.701350393759937 0.0510142718395002 -0.48650966132387 0.0315328097394332 miRNATAP -0.242224750785059 2.5038289694981e-08 NA NA NA hsa-miR-15b-5p LATS2 1.62046407540723 5.42152621571078e-09 -0.48650966132387 0.0315328097394332 miRNATAP -0.310505504258765 1.09269022566513e-08 NA NA NA hsa-miR-16-5p LATS2 1.00515772948091 5.33912942007619e-06 -0.48650966132387 0.0315328097394332 miRNATAP -0.402507422658803 9.23390641269043e-09 NA NA NA hsa-miR-188-5p LATS2 1.35426907033843 0.00038346077691455 -0.48650966132387 0.0315328097394332 PITA -0.129993364178461 0.00176919126915964 NA NA NA hsa-miR-200b-3p LATS2 0.974577911407732 0.0595020056914543 -0.48650966132387 0.0315328097394332 TargetScan -0.112521207660568 0.000254070831509551 NA NA NA hsa-miR-200c-3p LATS2 1.28185685499076 0.00369777635539177 -0.48650966132387 0.0315328097394332 miRNATAP -0.18879779093848 7.88302579646822e-08 NA NA NA hsa-miR-25-3p LATS2 1.00604871526544 0.000421838061147906 -0.48650966132387 0.0315328097394332 miRNATAP -0.203921079481627 0.000249530050102705 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-27a-3p LATS2 1.29886998470345 2.68986118553486e-08 -0.48650966132387 0.0315328097394332 miRNATAP -0.294742069257113 8.84568637613741e-06 NA NA NA hsa-miR-27b-3p LATS2 0.0836323965901755 0.725273923274 -0.48650966132387 0.0315328097394332 miRNATAP -0.266262727582266 9.23924068089746e-05 NA NA NA hsa-miR-32-5p LATS2 0.415247682945382 0.106458022460373 -0.48650966132387 0.0315328097394332 miRNATAP -0.214305608914373 0.000657264609981715 NA NA NA hsa-miR-33a-3p LATS2 0.347011402017138 0.321709379745392 -0.48650966132387 0.0315328097394332 mirMAP -0.249035679424423 1.45185628992976e-07 NA NA NA hsa-miR-361-5p LATS2 0.407725414130987 0.0181260969156347 -0.48650966132387 0.0315328097394332 miRanda -0.41013361664315 1.47923016340322e-05 NA NA NA hsa-miR-424-5p LATS2 1.08509868581983 0.000420473853818268 -0.48650966132387 0.0315328097394332 miRNATAP -0.231257182235983 5.92587793093671e-06 NA NA NA hsa-miR-429 LATS2 1.40182602301928 0.00900426780286475 -0.48650966132387 0.0315328097394332 PITA;miRanda;miRNATAP -0.139774754536802 1.62173240647016e-06 NA NA NA hsa-miR-455-5p LATS2 1.20462751989145 6.74386011867484e-05 -0.48650966132387 0.0315328097394332 miRanda -0.145364124824675 0.00574277985200353 NA NA NA hsa-miR-590-3p LATS2 1.11654983899947 0.000160782154924864 -0.48650966132387 0.0315328097394332 PITA;miRanda -0.195591827533022 0.000257282024827439 NA NA NA hsa-miR-92a-3p LATS2 1.2209325870225 6.8757197708107e-06 -0.48650966132387 0.0315328097394332 miRNATAP -0.281217858415003 8.92211047316167e-07 NA NA NA hsa-miR-93-5p LATS2 1.7515174434778 1.59386482413883e-08 -0.48650966132387 0.0315328097394332 miRNAWalker2_validate -0.210173094645838 2.25963287772886e-05 NA NA NA hsa-miR-96-5p LATS2 1.14243043653372 0.00942969392739105 -0.48650966132387 0.0315328097394332 miRNATAP -0.221848798966681 1.57113861556665e-09 NA NA NA hsa-miR-7-1-3p LEF1 0.709309110750947 0.0412301737463194 1.62041926135487 4.56974660298132e-05 mirMAP -0.215763577578317 0.00939527019662836 NA NA NA hsa-let-7a-3p LIMD1 0.503048155002889 0.0411145454335299 -0.375627830256168 0.0527709353118286 mirMAP -0.153000921044653 0.00668759889417749 NA NA NA hsa-miR-199a-3p LIMD1 0.85352674491639 0.000360518331912285 -0.375627830256168 0.0527709353118286 mirMAP -0.304565507308069 5.02669617614606e-08 NA NA NA hsa-miR-199a-5p LIMD1 0.371973504507027 0.232661597228763 -0.375627830256168 0.0527709353118286 miRanda -0.171621641082036 9.48179164820607e-05 NA NA NA hsa-miR-199b-3p LIMD1 0.860968252593043 0.00032297319521262 -0.375627830256168 0.0527709353118286 mirMAP -0.30392770287534 5.21990508074584e-08 NA NA NA hsa-miR-199b-5p LIMD1 0.124595928096068 0.678156859366405 -0.375627830256168 0.0527709353118286 miRanda -0.153828264300621 0.000824251554353234 NA NA NA hsa-miR-2355-5p LIMD1 0.594869787574182 0.120591076715177 -0.375627830256168 0.0527709353118286 mirMAP -0.121543368405472 0.00066979008073081 NA NA NA hsa-miR-23a-3p LIMD1 1.10685926969665 3.16223452471768e-08 -0.375627830256168 0.0527709353118286 mirMAP -0.273051844368404 4.54848394074732e-05 NA NA NA hsa-miR-24-3p LIMD1 1.08578167539644 6.18549359075268e-07 -0.375627830256168 0.0527709353118286 miRNAWalker2_validate;MirTarget -0.226927493304109 0.000249407440967687 NA NA NA hsa-miR-342-3p LIMD1 0.318119432680668 0.269150960124243 -0.375627830256168 0.0527709353118286 MirTarget;miRanda -0.205303748401359 1.54544522251658e-05 NA NA NA hsa-miR-382-5p LIMD1 0.592305208032135 0.0451384362870204 -0.375627830256168 0.0527709353118286 mirMAP -0.179937678873753 0.00010037800444839 NA NA NA hsa-miR-3922-3p LIMD1 1.33252322927569 0.000665307190249975 -0.375627830256168 0.0527709353118286 MirTarget -0.114413214554959 0.0045185334579734 NA NA NA hsa-miR-409-5p LIMD1 1.11288618205388 0.000885233506076774 -0.375627830256168 0.0527709353118286 MirTarget -0.145461216341087 0.000339732871499154 NA NA NA hsa-miR-452-5p LIMD1 2.08756506185889 0.000258095769002813 -0.375627830256168 0.0527709353118286 mirMAP -0.109918690388135 2.17890835749425e-06 NA NA NA hsa-miR-485-3p LIMD1 0.402652239390796 0.291980476362068 -0.375627830256168 0.0527709353118286 PITA;mirMAP -0.125145304978418 0.00056152005418047 NA NA NA hsa-miR-362-3p LLGL1 -0.0349414695893027 0.913780708043777 0.139615690225274 0.52261038352481 miRNATAP -0.206478150018279 1.46607561699815e-05 NA NA NA hsa-miR-146b-3p LLGL2 1.10138643500522 3.66835580263893e-05 0.181017700911858 0.697588094103407 miRNATAP -0.331430454045311 0.00700289679845618 NA NA NA hsa-miR-199a-3p LLGL2 0.85352674491639 0.000360518331912285 0.181017700911858 0.697588094103407 PITA;miRNATAP -0.710460064010149 1.36451928188925e-07 NA NA NA hsa-miR-199b-3p LLGL2 0.860968252593043 0.00032297319521262 0.181017700911858 0.697588094103407 PITA;miRNATAP -0.706573894979876 1.56823584210983e-07 NA NA NA hsa-miR-152-3p MPP5 0.436002345388935 0.161701199884702 -0.401877106554193 0.0184686916015463 MirTarget -0.186946729196761 1.00542532736412e-06 NA NA NA hsa-miR-199a-5p MPP5 0.371973504507027 0.232661597228763 -0.401877106554193 0.0184686916015463 MirTarget;PITA;miRanda;miRNATAP -0.112487753859498 0.00393521288137107 NA NA NA hsa-miR-23a-3p MPP5 1.10685926969665 3.16223452471768e-08 -0.401877106554193 0.0184686916015463 MirTarget -0.172403093520178 0.00377223497256778 NA NA NA hsa-miR-409-5p MPP5 1.11288618205388 0.000885233506076774 -0.401877106554193 0.0184686916015463 PITA -0.105854431338365 0.00318905777659594 NA NA NA hsa-miR-542-3p MPP5 0.757649022262991 0.00210575463285599 -0.401877106554193 0.0184686916015463 miRanda -0.161787643172629 0.000968122168723605 NA NA NA hsa-miR-590-3p MPP5 1.11654983899947 0.000160782154924864 -0.401877106554193 0.0184686916015463 MirTarget;PITA;miRanda;miRNATAP -0.110313401289312 0.00648336670838304 NA NA NA hsa-let-7g-5p MYC 0.325297685027927 0.241142963826631 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.208004338135784 0.00889968380877331 NA NA NA hsa-miR-26a-5p MYC -0.384110714440647 0.0442498636014044 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.595250601703361 1.86863162610225e-07 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 1.59953351087307 5.56170899867314e-05 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.211331388667708 7.8766835557931e-05 NA NA NA hsa-miR-34a-5p MYC 0.794251341270032 0.00024017386701179 0.519157788027723 0.0906694636452631 miRNAWalker2_validate;miRTarBase -0.342899797750895 0.000672118391671011 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.832613878736338 0.000791321227103338 0.519157788027723 0.0906694636452631 miRNAWalker2_validate -0.242528994449528 0.00588609161419062 NA NA NA hsa-miR-29b-2-5p NF2 -1.7015307882027 2.84239251703401e-10 -0.203792515836081 0.220498946938917 mirMAP -0.143172049579166 0.000574353721229948 NA NA NA hsa-miR-29b-3p NF2 -0.230693226193598 0.367461626035234 -0.203792515836081 0.220498946938917 mirMAP -0.137700859057022 0.00295919476121628 NA NA NA hsa-miR-29c-3p NF2 -1.62454036584589 5.38376515586029e-07 -0.203792515836081 0.220498946938917 mirMAP -0.107820652445864 0.00219125722865348 NA NA NA hsa-miR-3614-3p NF2 0.816988052098069 0.0143572924352078 -0.203792515836081 0.220498946938917 MirTarget;miRNATAP -0.166720713314019 3.08934338070319e-06 NA NA NA hsa-miR-330-5p NKD1 0.488365986827708 0.0512207630808233 -0.769178946603763 0.21762886866008 miRanda;miRNATAP -0.615864824389352 0.00054564164094576 NA NA NA hsa-miR-532-5p NKD1 0.313080805824184 0.252248939356301 -0.769178946603763 0.21762886866008 PITA;miRNATAP -0.469706308550897 0.00418081175978949 NA NA NA hsa-miR-511-5p PARD3 0.542335183701817 0.127507740178883 -0.0754115617555193 0.808442526162465 MirTarget -0.180511241965251 0.00362628756556189 NA NA NA hsa-miR-146b-3p PARD6A 1.10138643500522 3.66835580263893e-05 -0.51341444719612 0.231670611490232 miRNATAP -0.370096733019744 0.00104509918896615 NA NA NA hsa-miR-409-3p PARD6A 0.648757698056077 0.0515133779537138 -0.51341444719612 0.231670611490232 miRNATAP -0.363044387754216 6.410400648479e-05 NA NA NA hsa-let-7a-3p PARD6B 0.503048155002889 0.0411145454335299 0.155568965740892 0.707257319775646 MirTarget;miRNATAP -0.433896573843651 0.000292443387091716 NA NA NA hsa-let-7b-3p PARD6B 0.21838629112113 0.296038413622566 0.155568965740892 0.707257319775646 MirTarget;miRNATAP -0.54781455788693 0.000121943657475778 NA NA NA hsa-let-7b-5p PARD6B 0.0582902155815681 0.781400138984745 0.155568965740892 0.707257319775646 MirTarget;miRNATAP -0.822660225604909 2.73245264722406e-09 NA NA NA hsa-let-7c-5p PARD6B -0.503482361446512 0.206848395212976 0.155568965740892 0.707257319775646 MirTarget -0.262740612034798 0.000341083947331532 NA NA NA hsa-miR-143-5p PARD6B -0.452341959646033 0.125356933437373 0.155568965740892 0.707257319775646 MirTarget -0.376726445413679 0.000152000282231262 NA NA NA hsa-miR-205-5p PARD6B 3.13520672931882 0.0293226471971167 0.155568965740892 0.707257319775646 miRNATAP -0.174616366414126 1.44621262155985e-21 NA NA NA hsa-miR-2355-3p PARD6B 0.982963823342009 0.0229275810851348 0.155568965740892 0.707257319775646 MirTarget;miRNATAP -0.346212276871433 2.62811286009642e-07 NA NA NA hsa-miR-27a-3p PARD6B 1.29886998470345 2.68986118553486e-08 0.155568965740892 0.707257319775646 MirTarget;miRNATAP -0.769486282134441 6.42023226533276e-11 NA NA NA hsa-miR-27b-3p PARD6B 0.0836323965901755 0.725273923274 0.155568965740892 0.707257319775646 MirTarget;miRNATAP -0.784751076153409 6.75126851798139e-11 NA NA NA hsa-miR-34c-3p PARD6B 2.25273698056457 9.06191072601281e-05 0.155568965740892 0.707257319775646 mirMAP -0.285527435086934 6.06825227654193e-09 NA NA NA hsa-miR-34c-5p PARD6B 2.20632574870337 0.000379662996168678 0.155568965740892 0.707257319775646 miRanda;miRNATAP -0.272064631726122 1.87058534823027e-09 NA NA NA hsa-miR-409-3p PARD6B 0.648757698056077 0.0515133779537138 0.155568965740892 0.707257319775646 PITA -0.280391447253876 0.00146965502116406 NA NA NA hsa-miR-411-5p PARD6B 0.0190472168701112 0.956112053787566 0.155568965740892 0.707257319775646 MirTarget -0.28419754299869 0.000867917459135238 NA NA NA hsa-miR-9-3p PARD6B 0.330346058941473 0.541111939982661 0.155568965740892 0.707257319775646 miRNATAP -0.160706091486055 0.00460029081623173 NA NA NA hsa-miR-944 PARD6B 3.33123095809751 0.0177835044930391 0.155568965740892 0.707257319775646 mirMAP;miRNATAP -0.225759826066156 4.5676686994284e-25 NA NA NA hsa-miR-217 PARD6G -0.0121404731225336 0.980818372851502 0.550877351055699 0.345791605047943 miRanda -0.284946513547505 0.000502255885005431 NA NA NA hsa-miR-125a-5p PPP1CA -0.878090699011564 0.000213630844319685 0.828484899181915 2.3242868219334e-05 miRanda;miRNATAP -0.307831646874176 1.13047894861249e-07 NA NA NA hsa-miR-125b-5p PPP1CA -0.509303501421334 0.133265526313161 0.828484899181915 2.3242868219334e-05 miRTarBase -0.127521896415734 0.00224435708833251 25240408 MiR 125b promotes cell migration and invasion by targeting PPP1CA Rb signal pathways in gastric cancer resulting in a poor prognosis; MiR-125b was upregulated in gastric cancer tissues and cell lines and significantly promoted cellular proliferation migration and invasion by downregulating the expression of PPP1CA and upregulating Rb phosphorylation; MiR-125b functions as an oncogene by targeting downregulated PPP1CA and upregulated Rb phosphorylation in gastric cancer worse prognosis;cell migration gastric cancer hsa-miR-140-3p PPP1CB -0.296251775392129 0.127539826012144 -0.423223190455937 0.023017825519843 miRNATAP -0.257614418521063 0.000194085262641422 NA NA NA hsa-miR-140-5p PPP1CB 0.208193069681326 0.303002433893804 -0.423223190455937 0.023017825519843 miRanda -0.240348593696483 0.000301733519254791 NA NA NA hsa-miR-148a-3p PPP1CB -1.53721533763578 3.55533747293117e-05 -0.423223190455937 0.023017825519843 miRNATAP -0.147650887784072 1.82492345720235e-05 NA NA NA hsa-miR-148a-5p PPP1CB -0.69329616490858 0.0793012233740369 -0.423223190455937 0.023017825519843 mirMAP -0.169308745660691 2.09451527113886e-07 NA NA NA hsa-miR-181a-5p PPP1CB 1.39227281909646 1.91689469974826e-09 -0.423223190455937 0.023017825519843 mirMAP;miRNATAP -0.171227408637844 0.00193870226923298 NA NA NA hsa-miR-181b-5p PPP1CB 1.64216500592669 1.89228845300725e-08 -0.423223190455937 0.023017825519843 mirMAP;miRNATAP -0.150028591104091 0.000585764038205564 NA NA NA hsa-miR-181c-5p PPP1CB 0.336826967681288 0.112932307913601 -0.423223190455937 0.023017825519843 mirMAP;miRNATAP -0.166542533976813 0.00868454450644346 NA NA NA hsa-miR-186-5p PPP1CB 0.149964130725901 0.434709542998771 -0.423223190455937 0.023017825519843 miRNATAP -0.228462466138701 0.00119889553133633 NA NA NA hsa-miR-200b-3p PPP1CB 0.974577911407732 0.0595020056914543 -0.423223190455937 0.023017825519843 TargetScan -0.102714988811412 4.4328417888413e-05 NA NA NA hsa-miR-320b PPP1CB 1.11183660885284 0.000497971211648503 -0.423223190455937 0.023017825519843 miRNATAP -0.152025319019011 0.000189003222844986 NA NA NA hsa-miR-338-3p PPP1CB -0.959276231066179 0.0191473351014091 -0.423223190455937 0.023017825519843 PITA;miRanda -0.16020987322538 3.33970849915964e-07 NA NA NA hsa-miR-338-5p PPP1CB -1.19659203838734 0.0100316010080496 -0.423223190455937 0.023017825519843 mirMAP;miRNATAP -0.119463672028654 1.78752922580498e-05 NA NA NA hsa-miR-362-3p PPP1CB -0.0349414695893027 0.913780708043777 -0.423223190455937 0.023017825519843 miRanda -0.138640584360544 0.000757721207580068 NA NA NA hsa-miR-501-5p PPP1CB 0.266919328110625 0.454779001968586 -0.423223190455937 0.023017825519843 PITA;miRNATAP -0.156902104056982 1.87766774869976e-05 NA NA NA hsa-miR-7-1-3p PPP1CB 0.709309110750947 0.0412301737463194 -0.423223190455937 0.023017825519843 mirMAP -0.25945370299294 5.43251268572421e-13 NA NA NA hsa-miR-30a-5p PPP1CC -1.71922855140016 3.20574349285256e-07 0.29564206748054 0.0147280038355921 miRNAWalker2_validate -0.103125844886494 2.19887249904711e-05 NA NA NA hsa-miR-125a-5p PPP2CA -0.878090699011564 0.000213630844319685 0.107480872641697 0.465806526802027 miRanda -0.114553295277737 0.00863062624749295 NA NA NA hsa-miR-29b-2-5p PPP2CA -1.7015307882027 2.84239251703401e-10 0.107480872641697 0.465806526802027 MirTarget -0.167053730308545 4.03703216535852e-06 NA NA NA hsa-miR-30a-5p PPP2CA -1.71922855140016 3.20574349285256e-07 0.107480872641697 0.465806526802027 mirMAP -0.106261777400481 0.000351504273062397 NA NA NA hsa-miR-30c-5p PPP2CA -0.983130268805942 4.60419218706127e-05 0.107480872641697 0.465806526802027 mirMAP -0.161256288873208 0.000136064658332901 NA NA NA hsa-miR-362-5p PPP2CA -0.354508685915981 0.354912078595613 0.107480872641697 0.465806526802027 TargetScan -0.108020662373963 5.45175893302357e-05 NA NA NA hsa-miR-7-1-3p PPP2CA 0.709309110750947 0.0412301737463194 0.107480872641697 0.465806526802027 mirMAP -0.107071670444797 0.000292904076066977 NA NA NA hsa-miR-199a-5p PPP2R1A 0.371973504507027 0.232661597228763 0.14708086066668 0.243477712111288 miRanda -0.114770859181242 4.51006863190664e-05 NA NA NA hsa-miR-199b-5p PPP2R1A 0.124595928096068 0.678156859366405 0.14708086066668 0.243477712111288 miRanda -0.103378943853271 0.000445497151882613 NA NA NA hsa-miR-107 PPP2R2B 0.904627575346218 4.67936495073904e-05 -1.3848126684449 0.0554407143297931 miRanda -0.881242719933643 0.000126451671605244 NA NA NA hsa-miR-10a-3p PPP2R2B 0.221754213874695 0.560576719784617 -1.3848126684449 0.0554407143297931 mirMAP -0.46590236767074 0.000789996723160265 NA NA NA hsa-miR-141-3p PPP2R2B 1.45548825076434 0.00115958850961764 -1.3848126684449 0.0554407143297931 TargetScan -0.318798973090571 0.00511860905441799 NA NA NA hsa-miR-7-1-3p PPP2R2B 0.709309110750947 0.0412301737463194 -1.3848126684449 0.0554407143297931 mirMAP -0.706851932309068 1.2127865011212e-06 NA NA NA hsa-miR-939-5p PPP2R2B 0.857156740351386 0.0124815824643173 -1.3848126684449 0.0554407143297931 MirTarget -0.4493190221977 0.0064643062846425 NA NA NA hsa-miR-10a-3p PPP2R2C 0.221754213874695 0.560576719784617 1.02451824111908 0.395893091124292 mirMAP -0.946858095708182 3.60912842273225e-05 NA NA NA hsa-miR-148b-5p PPP2R2C 1.04409494910362 0.00195860954157389 1.02451824111908 0.395893091124292 mirMAP -0.822394723533385 0.00111145552530622 NA NA NA hsa-miR-192-5p PPP2R2C 0.0809146624034405 0.941057093528709 1.02451824111908 0.395893091124292 mirMAP -0.708176321025325 2.06966046175514e-24 NA NA NA hsa-miR-194-5p PPP2R2C -0.127742909829168 0.906065815804667 1.02451824111908 0.395893091124292 miRNATAP -0.723575440173531 4.54685564985729e-25 NA NA NA hsa-miR-200b-3p PPP2R2C 0.974577911407732 0.0595020056914543 1.02451824111908 0.395893091124292 TargetScan -0.510159719900787 0.00198489425630945 NA NA NA hsa-miR-500a-3p PPP2R2C 0.133193057420744 0.668896091969871 1.02451824111908 0.395893091124292 MirTarget -0.99472150817674 0.000314223961166972 NA NA NA hsa-miR-501-3p PPP2R2C 0.731876211669996 0.0270421347018303 1.02451824111908 0.395893091124292 MirTarget;PITA;TargetScan;miRNATAP -0.836830265997514 0.00121332256212682 NA NA NA hsa-miR-502-3p PPP2R2C -0.16442685491191 0.557471818466728 1.02451824111908 0.395893091124292 MirTarget;PITA;miRNATAP -1.51802501856502 5.36029253290157e-07 NA NA NA hsa-miR-625-5p PPP2R2C 0.537211086526376 0.203801009380384 1.02451824111908 0.395893091124292 MirTarget -1.45420667074092 3.53918596162486e-14 NA NA NA hsa-miR-365a-3p PRKCI -0.891537000455889 0.0025537650440002 0.36237459420094 0.13866463232141 MirTarget -0.219197314016358 0.000163162612737288 NA NA NA hsa-miR-152-3p PRKCZ 0.436002345388935 0.161701199884702 0.5645621390963 0.0363722231186805 MirTarget -0.186619755973606 0.00257311290499769 NA NA NA hsa-miR-342-3p RASSF1 0.318119432680668 0.269150960124243 -0.278399268420359 0.187863204184993 PITA;miRNATAP -0.203885758783446 8.61139899748433e-05 NA NA NA hsa-miR-127-5p RASSF6 0.684144175589776 0.021634535736883 -1.03387820398569 0.0727693155263852 mirMAP -0.402391415821208 0.00359809323454034 NA NA NA hsa-miR-130a-3p RASSF6 0.146223920674657 0.633739795905839 -1.03387820398569 0.0727693155263852 mirMAP -0.757811348080386 6.65039583916609e-09 NA NA NA hsa-miR-203a-3p RASSF6 1.44736908507496 0.0394116388736904 -1.03387820398569 0.0727693155263852 MirTarget -0.239834367078422 2.90726968278052e-05 NA NA NA hsa-miR-218-5p RASSF6 -0.987730614742492 0.0108295837207062 -1.03387820398569 0.0727693155263852 MirTarget;mirMAP -0.495557437665825 1.69881917977856e-06 NA NA NA hsa-miR-34c-5p RASSF6 2.20632574870337 0.000379662996168678 -1.03387820398569 0.0727693155263852 MirTarget -0.378160825836 2.3392311820721e-09 NA NA NA hsa-miR-361-5p RASSF6 0.407725414130987 0.0181260969156347 -1.03387820398569 0.0727693155263852 miRanda -0.826645739942239 0.000709879045304562 NA NA NA hsa-miR-944 RASSF6 3.33123095809751 0.0177835044930391 -1.03387820398569 0.0727693155263852 MirTarget;mirMAP -0.241622462245369 1.00180166683423e-13 NA NA NA hsa-miR-107 SAV1 0.904627575346218 4.67936495073904e-05 -0.159519668667515 0.42941547569771 PITA;miRanda;miRNATAP -0.210697972959817 0.000961323718596926 NA NA NA hsa-miR-126-5p SAV1 0.41765430251855 0.0753161203651532 -0.159519668667515 0.42941547569771 mirMAP -0.204939702266031 0.000825082224073531 NA NA NA hsa-miR-7-1-3p SAV1 0.709309110750947 0.0412301737463194 -0.159519668667515 0.42941547569771 mirMAP -0.111104466297055 0.00683547254492719 NA NA NA hsa-miR-129-5p SERPINE1 -2.56914016541176 2.36237896095709e-06 0.873189054905582 0.11255072331134 miRanda -0.19644165437006 0.00589849447253088 NA NA NA hsa-miR-148a-3p SERPINE1 -1.53721533763578 3.55533747293117e-05 0.873189054905582 0.11255072331134 miRNATAP -0.436559131161047 1.9709933577873e-05 NA NA NA hsa-miR-148a-5p SERPINE1 -0.69329616490858 0.0793012233740369 0.873189054905582 0.11255072331134 miRNATAP -0.527300729477906 4.57253053812486e-08 NA NA NA hsa-miR-2110 SERPINE1 0.759864042760204 0.0723961390557655 0.873189054905582 0.11255072331134 miRNATAP -0.330642930294297 0.000392739120335177 NA NA NA hsa-miR-30b-5p SERPINE1 -0.430720743745757 0.0593564057320791 0.873189054905582 0.11255072331134 MirTarget -0.723431021861993 2.57885394455558e-05 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -0.983130268805942 4.60419218706127e-05 0.873189054905582 0.11255072331134 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.480138224039187 0.00294414713695789 NA NA NA hsa-miR-30d-5p SERPINE1 -0.5492586056147 0.0140125082460125 0.873189054905582 0.11255072331134 miRNATAP -0.997455560362319 6.34120387227326e-09 NA NA NA hsa-miR-378a-5p SERPINE1 -0.557166502179376 0.0344581590006454 0.873189054905582 0.11255072331134 MirTarget -0.612665935436298 3.5388157525321e-05 NA NA NA hsa-miR-769-5p SERPINE1 1.14821899306381 1.27143750879772e-06 0.873189054905582 0.11255072331134 MirTarget;miRNATAP -0.506471309568269 0.0018700765705002 NA NA NA hsa-miR-139-5p SMAD1 -1.83374360776637 1.22019901002824e-09 0.429264994982459 0.0273558211866855 miRanda -0.128051425678499 0.00362698431570782 NA NA NA hsa-miR-26a-5p SMAD1 -0.384110714440647 0.0442498636014044 0.429264994982459 0.0273558211866855 miRNAWalker2_validate;miRTarBase;MirTarget -0.195821340863474 0.00826809100398995 23190898 In surveying targets of miR-26a we found that protein levels of SMAD1 mothers against decapentaplegic homolog 1 and BAG-4/SODD were strongly decreased in sensitive cells treated with miR-26a mimic as compared with the control melanoma hsa-miR-30a-5p SMAD1 -1.71922855140016 3.20574349285256e-07 0.429264994982459 0.0273558211866855 miRNAWalker2_validate;miRTarBase -0.117413987267556 0.00327032717369617 NA NA NA hsa-miR-30b-5p SMAD1 -0.430720743745757 0.0593564057320791 0.429264994982459 0.0273558211866855 miRNAWalker2_validate;miRTarBase -0.206089342999676 0.000735118640894747 NA NA NA hsa-miR-7-1-3p SMAD1 0.709309110750947 0.0412301737463194 0.429264994982459 0.0273558211866855 MirTarget -0.128425052883193 0.00118983037556634 NA NA NA hsa-miR-142-5p SMAD2 1.55592486377018 6.69269968016779e-06 -0.300765856171448 0.10851640185339 mirMAP;miRNATAP -0.121258906437032 0.00121258964778295 NA NA NA hsa-miR-148b-3p SMAD2 0.295175884456199 0.17466422420702 -0.300765856171448 0.10851640185339 MirTarget;mirMAP -0.188431302458534 0.00237431170323455 NA NA NA hsa-miR-338-5p SMAD2 -1.19659203838734 0.0100316010080496 -0.300765856171448 0.10851640185339 mirMAP -0.1164613959073 3.14493757487898e-05 NA NA NA hsa-miR-361-3p SMAD2 -0.126462931388735 0.566052688733137 -0.300765856171448 0.10851640185339 miRNATAP -0.221052512732111 0.000287801161304295 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-3614-5p SMAD2 1.10426689932954 0.00706308396674599 -0.300765856171448 0.10851640185339 mirMAP -0.138520175891015 1.61724289790087e-05 NA NA NA hsa-miR-362-3p SMAD2 -0.0349414695893027 0.913780708043777 -0.300765856171448 0.10851640185339 PITA;miRNATAP -0.122162976410172 0.00320094476209477 NA NA NA hsa-miR-501-5p SMAD2 0.266919328110625 0.454779001968586 -0.300765856171448 0.10851640185339 mirMAP -0.104465988541894 0.00508261334911037 NA NA NA hsa-miR-532-5p SMAD2 0.313080805824184 0.252248939356301 -0.300765856171448 0.10851640185339 MirTarget -0.141928514558377 0.00372479166804462 NA NA NA hsa-miR-652-3p SMAD2 1.02742852909286 0.000337974815149397 -0.300765856171448 0.10851640185339 miRNAWalker2_validate -0.133269515054385 0.00370559099257 NA NA NA hsa-miR-7-1-3p SMAD2 0.709309110750947 0.0412301737463194 -0.300765856171448 0.10851640185339 mirMAP -0.128099023068285 0.000745445261862172 NA NA NA hsa-miR-29b-2-5p SMAD3 -1.7015307882027 2.84239251703401e-10 0.496358301383941 0.0477537564173643 mirMAP -0.245782961497944 9.53741523036621e-05 NA NA NA hsa-miR-326 SMAD3 -0.429748586406214 0.2629894124021 0.496358301383941 0.0477537564173643 miRanda -0.188699053546072 5.05451980443311e-05 NA NA NA hsa-miR-501-5p SMAD3 0.266919328110625 0.454779001968586 0.496358301383941 0.0477537564173643 mirMAP -0.172629265416163 0.000540972457841411 NA NA NA hsa-let-7f-1-3p SMAD4 1.28704406797397 1.17954701106157e-06 -0.824257248233094 0.000189487671904837 mirMAP -0.220578983472878 0.000160738336591292 NA NA NA hsa-miR-106b-5p SMAD4 1.70863907461894 2.04074794107142e-08 -0.824257248233094 0.000189487671904837 mirMAP;miRNATAP -0.162181577178144 0.00128196766251867 NA NA NA hsa-miR-10b-3p SMAD4 0.773619331000039 0.0076628900286607 -0.824257248233094 0.000189487671904837 miRNATAP -0.242227670204784 7.12567725926528e-06 NA NA NA hsa-miR-142-5p SMAD4 1.55592486377018 6.69269968016779e-06 -0.824257248233094 0.000189487671904837 mirMAP -0.170942442548877 0.00013009423445379 NA NA NA hsa-miR-188-5p SMAD4 1.35426907033843 0.00038346077691455 -0.824257248233094 0.000189487671904837 mirMAP -0.13185965458528 0.00131015049885176 NA NA NA hsa-miR-330-3p SMAD4 0.798460296022179 0.00746538156533435 -0.824257248233094 0.000189487671904837 mirMAP -0.142069953334962 0.0076701388483449 NA NA NA hsa-miR-3614-5p SMAD4 1.10426689932954 0.00706308396674599 -0.824257248233094 0.000189487671904837 mirMAP -0.1516680963036 8.74983580862871e-05 NA NA NA hsa-miR-3922-3p SMAD4 1.33252322927569 0.000665307190249975 -0.824257248233094 0.000189487671904837 miRNATAP -0.123847527593907 0.00790979730625974 NA NA NA hsa-miR-421 SMAD4 1.80720854070385 1.59709651202848e-07 -0.824257248233094 0.000189487671904837 miRTarBase;miRanda;miRNATAP -0.118947234882816 0.00792590774144633 NA NA NA hsa-miR-550a-3p SMAD4 2.05849884025997 7.99642185793604e-07 -0.824257248233094 0.000189487671904837 mirMAP -0.10817430665783 0.00838028029306833 NA NA NA hsa-miR-106b-5p SMAD7 1.70863907461894 2.04074794107142e-08 -0.586609343981219 0.00896578617474772 miRNATAP -0.200542271048719 6.88688081722028e-05 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-15b-5p SMAD7 1.62046407540723 5.42152621571078e-09 -0.586609343981219 0.00896578617474772 miRNAWalker2_validate;MirTarget;miRNATAP -0.194934011728275 0.000440193376407283 NA NA NA hsa-miR-17-5p SMAD7 1.65862087862483 8.45603406215941e-08 -0.586609343981219 0.00896578617474772 TargetScan;miRNATAP -0.141128748170169 0.00497113413012141 NA NA NA hsa-miR-182-5p SMAD7 0.887369486030646 0.0310640781418789 -0.586609343981219 0.00896578617474772 miRNATAP -0.113310663552914 0.00344464027904897 NA NA NA hsa-miR-185-3p SMAD7 1.33711019171256 3.45756583967985e-05 -0.586609343981219 0.00896578617474772 MirTarget -0.14286725065928 0.00341513824110895 NA NA NA hsa-miR-32-5p SMAD7 0.415247682945382 0.106458022460373 -0.586609343981219 0.00896578617474772 MirTarget;miRNATAP -0.180652914298042 0.00404902034012319 NA NA NA hsa-miR-324-3p SMAD7 1.04940352369965 0.000387716796520961 -0.586609343981219 0.00896578617474772 MirTarget -0.149567233505859 0.00540203108878322 NA NA NA hsa-miR-590-5p SMAD7 1.04171442093217 0.000272475544954865 -0.586609343981219 0.00896578617474772 MirTarget;PITA;miRanda;miRNATAP -0.153179414780151 0.00584573757090831 NA NA NA hsa-miR-92a-3p SMAD7 1.2209325870225 6.8757197708107e-06 -0.586609343981219 0.00896578617474772 miRNAWalker2_validate;MirTarget;miRNATAP -0.184170362640237 0.00148686126672541 NA NA NA hsa-miR-93-5p SMAD7 1.7515174434778 1.59386482413883e-08 -0.586609343981219 0.00896578617474772 miRNATAP -0.134194879747516 0.00731083258713993 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-96-5p SMAD7 1.14243043653372 0.00942969392739105 -0.586609343981219 0.00896578617474772 TargetScan;miRNATAP -0.109635718982445 0.00380983286871753 NA NA NA hsa-miR-107 SNAI2 0.904627575346218 4.67936495073904e-05 0.8679564879757 0.163674726451342 miRanda -0.956073669477844 9.87262308538113e-07 NA NA NA hsa-miR-126-5p SNAI2 0.41765430251855 0.0753161203651532 0.8679564879757 0.163674726451342 MirTarget -0.698491882102722 0.000239984015988638 NA NA NA hsa-miR-140-5p SNAI2 0.208193069681326 0.303002433893804 0.8679564879757 0.163674726451342 miRanda -0.709926892739581 0.00155086520600903 25322669;27597739 Down regulation of miR 140 induces EMT and promotes invasion by targeting Slug in esophageal cancer; Slug a target gene of miR-140 was examined by luciferase assay and Western blot; miR-140 may regulate the cell invasion of EC via controlling Slug expression;Mechanistically Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA ceRNA for miR-140-5p to de-repress the expression of the target gene Slug ; esophageal cancer;liver cancer hsa-miR-148b-3p SNAI2 0.295175884456199 0.17466422420702 0.8679564879757 0.163674726451342 miRNAWalker2_validate -0.880275520162378 1.78722551968974e-05 NA NA NA hsa-miR-200b-3p SNAI2 0.974577911407732 0.0595020056914543 0.8679564879757 0.163674726451342 TargetScan -0.481058558788609 5.92706791955422e-09 NA NA NA hsa-miR-335-3p SNAI2 2.5197689063267 2.20084506976733e-09 0.8679564879757 0.163674726451342 mirMAP -0.308182854003903 0.00222866592387318 NA NA NA hsa-miR-3614-5p SNAI2 1.10426689932954 0.00706308396674599 0.8679564879757 0.163674726451342 MirTarget -0.422502185264929 9.17833069626897e-05 NA NA NA hsa-miR-375 SNAI2 -2.94506033785642 0.00570147601654791 0.8679564879757 0.163674726451342 miRanda -0.414986060133483 2.04706689528243e-32 NA NA NA hsa-miR-429 SNAI2 1.40182602301928 0.00900426780286475 0.8679564879757 0.163674726451342 PITA;miRanda;miRNATAP -0.392670133124033 1.01237240041389e-06 NA NA NA hsa-miR-532-5p SNAI2 0.313080805824184 0.252248939356301 0.8679564879757 0.163674726451342 PITA -1.32274651095458 1.34874826226459e-18 NA NA NA hsa-miR-140-3p SOX2 -0.296251775392129 0.127539826012144 -0.435659417587694 0.684924995251341 MirTarget -1.19723963586502 0.00290031832791056 23060440;25426255 We found that the stem cell self-renewal regulator SOX2 is a novel target of miR-140 and that this miR-140/SOX2 pathway critically regulates breast tumor-initiating cell survival providing a new link between ERα signaling and breast cancer stem cell maintenance;miR-140 plays an important tumor suppressive role in the Wnt SOX2 and SOX9 stem cell regulator pathways poor survival; breast cancer;breast cancer hsa-miR-34a-5p SOX2 0.794251341270032 0.00024017386701179 -0.435659417587694 0.684924995251341 miRNAWalker2_validate;miRTarBase -0.972301902286845 0.00608789063253052 NA NA NA hsa-miR-361-3p SOX2 -0.126462931388735 0.566052688733137 -0.435659417587694 0.684924995251341 miRNATAP -1.33039952426692 0.000147384179550797 NA NA NA hsa-miR-362-3p SOX2 -0.0349414695893027 0.913780708043777 -0.435659417587694 0.684924995251341 miRanda -0.664613874208126 0.00541633074062306 NA NA NA hsa-miR-625-5p SOX2 0.537211086526376 0.203801009380384 -0.435659417587694 0.684924995251341 MirTarget -0.714499925320122 7.07546396241142e-05 24508466 miR 625 down regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2; miR-625 down-regulation and Sox2 up-regulation were validated by qRT-PCR in 158 EC samples; Sox2 a target gene of miR-625 was examined by luciferase assay and western blot; Our data suggest that miR-625 may regulate the biological processes of EC via controlling Sox2 expression esophageal cancer hsa-miR-140-5p STK3 0.208193069681326 0.303002433893804 0.793333426435852 4.46637740570453e-05 PITA;miRanda -0.322602028873078 3.76711251888266e-06 NA NA NA hsa-miR-29b-2-5p STK3 -1.7015307882027 2.84239251703401e-10 0.793333426435852 4.46637740570453e-05 MirTarget -0.22121858449854 6.79621678083929e-06 NA NA NA hsa-miR-338-5p STK3 -1.19659203838734 0.0100316010080496 0.793333426435852 4.46637740570453e-05 PITA -0.149572483616068 3.11680052053363e-07 NA NA NA hsa-miR-362-3p STK3 -0.0349414695893027 0.913780708043777 0.793333426435852 4.46637740570453e-05 miRanda -0.117392435557393 0.00747078148579124 NA NA NA hsa-miR-24-3p TCF7 1.08578167539644 6.18549359075268e-07 0.591445675858013 0.106493932806469 miRNATAP -0.345072612513443 0.00353252223712274 NA NA NA hsa-miR-34c-5p TCF7 2.20632574870337 0.000379662996168678 0.591445675858013 0.106493932806469 miRanda -0.192032696486622 2.63084085306935e-06 NA NA NA hsa-miR-9-5p TCF7 -0.195328736653048 0.761470692992178 0.591445675858013 0.106493932806469 miRNATAP -0.18493062307769 3.31612851646122e-06 NA NA NA hsa-miR-141-3p TCF7L1 1.45548825076434 0.00115958850961764 -0.310224486571101 0.434739289227819 miRNAWalker2_validate -0.296591416139384 1.15195524480217e-06 NA NA NA hsa-miR-200a-3p TCF7L1 0.717826667295984 0.193912116506827 -0.310224486571101 0.434739289227819 miRNAWalker2_validate -0.381910856939776 7.78201775469161e-16 NA NA NA hsa-miR-200b-3p TCF7L1 0.974577911407732 0.0595020056914543 -0.310224486571101 0.434739289227819 miRNAWalker2_validate -0.415649212595845 1.51663654805539e-16 NA NA NA hsa-miR-200c-3p TCF7L1 1.28185685499076 0.00369777635539177 -0.310224486571101 0.434739289227819 miRNAWalker2_validate -0.303597119218901 9.84047938227416e-07 NA NA NA hsa-miR-30b-3p TCF7L1 -0.266398938200332 0.400847813143994 -0.310224486571101 0.434739289227819 MirTarget -0.305251654758347 0.000613842178627997 NA NA NA hsa-miR-30d-3p TCF7L1 -0.545113326540761 0.0433733076874155 -0.310224486571101 0.434739289227819 miRNATAP -0.369038254735927 0.000420745711451328 NA NA NA hsa-miR-326 TCF7L1 -0.429748586406214 0.2629894124021 -0.310224486571101 0.434739289227819 miRanda -0.199626096778859 0.00738862197777986 NA NA NA hsa-miR-362-3p TCF7L1 -0.0349414695893027 0.913780708043777 -0.310224486571101 0.434739289227819 miRanda;miRNATAP -0.288967677434562 0.00101792304796959 NA NA NA hsa-miR-429 TCF7L1 1.40182602301928 0.00900426780286475 -0.310224486571101 0.434739289227819 miRNAWalker2_validate -0.367126688182783 6.93640539817975e-14 NA NA NA hsa-let-7a-2-3p TCF7L2 0.195895719455896 0.643556335039042 0.27173995007013 0.313097533960113 MirTarget -0.235945297159224 1.40661753691119e-07 NA NA NA hsa-miR-1271-5p TCF7L2 1.15538250415776 0.00207865862606828 0.27173995007013 0.313097533960113 MirTarget -0.295468737177585 2.20649102710129e-09 NA NA NA hsa-miR-183-5p TCF7L2 1.65900927871187 0.000522025364980187 0.27173995007013 0.313097533960113 MirTarget;miRNATAP -0.139280796876202 0.000371794078066915 NA NA NA hsa-miR-24-2-5p TCF7L2 1.24948624677556 6.95051249640114e-07 0.27173995007013 0.313097533960113 MirTarget -0.229411279195174 0.00204717484854961 NA NA NA hsa-miR-328-3p TCF7L2 -0.380419131085598 0.160877064911118 0.27173995007013 0.313097533960113 MirTarget -0.269302116123654 0.000132209246547188 27181358 microRNA 328 inhibits cervical cancer cell proliferation and tumorigenesis by targeting TCF7L2; Bioinformatic analysis predicted TCF7L2 an essential effector of canonical Wnt signaling as a target gene of miR-328 which was confirmed by luciferase reporter assays; Enforced expression of miR-328 led to a decline in the expression of endogenous TCF7L2 in cervical cancer cells; In cervical cancer tissues TCF7L2 protein levels were negatively correlated with miR-328 expression levels r = -0.462 P = 0.017; Taken together our results provide first evidence for the growth suppressive activity of miR-328 in cervical cancer which is largely ascribed to downregulation of TCF7L2 tumorigenesis cervical and endocervical cancer hsa-miR-369-3p TCF7L2 0.32261175629684 0.3589927609891 0.27173995007013 0.313097533960113 miRNATAP -0.183011794271608 0.000750575305219771 NA NA NA hsa-miR-379-5p TCF7L2 0.0928358360950554 0.768753888894121 0.27173995007013 0.313097533960113 miRNATAP -0.356450010614149 1.29849061830873e-09 NA NA NA hsa-miR-655-3p TCF7L2 0.296138114843761 0.396423764161133 0.27173995007013 0.313097533960113 MirTarget -0.188495634363616 0.000606636282798544 NA NA NA hsa-miR-9-3p TCF7L2 0.330346058941473 0.541111939982661 0.27173995007013 0.313097533960113 miRNATAP -0.161533909515534 8.48554664109372e-06 NA NA NA hsa-miR-99a-3p TCF7L2 -0.889687200303901 0.0454814759729131 0.27173995007013 0.313097533960113 MirTarget;miRNATAP -0.184738103090508 7.11991929238854e-05 NA NA NA hsa-let-7b-3p TEAD1 0.21838629112113 0.296038413622566 -0.623204591064018 0.00226547295098981 MirTarget -0.203626079917931 0.0042992129653838 NA NA NA hsa-let-7f-1-3p TEAD1 1.28704406797397 1.17954701106157e-06 -0.623204591064018 0.00226547295098981 MirTarget -0.189600840756651 0.000422600685866349 NA NA NA hsa-miR-103a-3p TEAD1 0.840525139266028 5.83536475789158e-07 -0.623204591064018 0.00226547295098981 mirMAP -0.295527534832162 0.000655451565650659 NA NA NA hsa-miR-106b-5p TEAD1 1.70863907461894 2.04074794107142e-08 -0.623204591064018 0.00226547295098981 mirMAP -0.17820462344707 0.000105537116353766 NA NA NA hsa-miR-107 TEAD1 0.904627575346218 4.67936495073904e-05 -0.623204591064018 0.00226547295098981 mirMAP -0.218125260698269 0.000828895192686564 NA NA NA hsa-miR-128-3p TEAD1 0.98280381420517 5.77641850797209e-05 -0.623204591064018 0.00226547295098981 MirTarget -0.174575016561305 0.00324577954746862 NA NA NA hsa-miR-130b-3p TEAD1 1.32714007211004 4.78676252285191e-05 -0.623204591064018 0.00226547295098981 mirMAP -0.151529669432884 0.000543958593541405 NA NA NA hsa-miR-142-3p TEAD1 1.32364054836498 0.0001537753622128 -0.623204591064018 0.00226547295098981 MirTarget;PITA;miRNATAP -0.130486851748496 0.00148119558297745 NA NA NA hsa-miR-148b-3p TEAD1 0.295175884456199 0.17466422420702 -0.623204591064018 0.00226547295098981 MirTarget -0.213010573366829 0.00178217974958743 NA NA NA hsa-miR-151a-3p TEAD1 1.00322719901751 7.20903658270795e-06 -0.623204591064018 0.00226547295098981 mirMAP -0.195753399205378 0.00248252041636778 NA NA NA hsa-miR-15b-3p TEAD1 1.75738933306437 3.00554466232543e-08 -0.623204591064018 0.00226547295098981 mirMAP -0.129004890311892 0.00376437553052303 NA NA NA hsa-miR-16-1-3p TEAD1 1.43227522002564 3.70920454953168e-08 -0.623204591064018 0.00226547295098981 MirTarget;mirMAP -0.151307280520942 0.00562176876534696 NA NA NA hsa-miR-16-2-3p TEAD1 1.8048179609245 2.83095715136409e-09 -0.623204591064018 0.00226547295098981 mirMAP -0.121963018732792 0.00850711090982551 NA NA NA hsa-miR-185-5p TEAD1 1.14351510556643 1.07346945085714e-08 -0.623204591064018 0.00226547295098981 MirTarget;miRNATAP -0.230450022086973 0.00126077921975375 NA NA NA hsa-miR-186-5p TEAD1 0.149964130725901 0.434709542998771 -0.623204591064018 0.00226547295098981 MirTarget -0.213541734384311 0.00629564521124606 NA NA NA hsa-miR-200c-3p TEAD1 1.28185685499076 0.00369777635539177 -0.623204591064018 0.00226547295098981 miRNATAP -0.108371589739721 0.000887730187839624 NA NA NA hsa-miR-32-5p TEAD1 0.415247682945382 0.106458022460373 -0.623204591064018 0.00226547295098981 miRNATAP -0.222188598042584 9.03600242369627e-05 NA NA NA hsa-miR-320b TEAD1 1.11183660885284 0.000497971211648503 -0.623204591064018 0.00226547295098981 mirMAP -0.142004995835107 0.00167476836944867 NA NA NA hsa-miR-330-3p TEAD1 0.798460296022179 0.00746538156533435 -0.623204591064018 0.00226547295098981 MirTarget;PITA;miRNATAP -0.152149778737784 0.00180116773988973 NA NA NA hsa-miR-335-3p TEAD1 2.5197689063267 2.20084506976733e-09 -0.623204591064018 0.00226547295098981 MirTarget -0.109916923912776 0.000879578337992674 NA NA NA hsa-miR-335-5p TEAD1 1.59953351087307 5.56170899867314e-05 -0.623204591064018 0.00226547295098981 mirMAP;miRNATAP -0.116864692858653 0.00116783191783756 NA NA NA hsa-miR-425-5p TEAD1 1.13924952403101 0.000255357546232931 -0.623204591064018 0.00226547295098981 mirMAP -0.141411050453862 0.00225728913698041 NA NA NA hsa-miR-590-3p TEAD1 1.11654983899947 0.000160782154924864 -0.623204591064018 0.00226547295098981 MirTarget;PITA;miRanda;miRNATAP -0.1970394115687 4.52606617171154e-05 NA NA NA hsa-miR-624-5p TEAD1 1.03467956701702 0.0010908013402586 -0.623204591064018 0.00226547295098981 mirMAP -0.125922452103059 0.00943023358881362 NA NA NA hsa-let-7d-5p TEAD3 0.981733854788227 7.26366577706469e-07 -0.116898268772958 0.527375989496142 miRNATAP -0.203430567878729 0.00182816773548508 NA NA NA hsa-let-7g-5p TEAD3 0.325297685027927 0.241142963826631 -0.116898268772958 0.527375989496142 miRNATAP -0.204355464444268 1.24442791978988e-05 NA NA NA hsa-let-7i-5p TEAD3 0.798954594465461 2.99735653959449e-05 -0.116898268772958 0.527375989496142 miRNATAP -0.22539717710747 0.000957605800474073 NA NA NA hsa-miR-101-3p TEAD3 -0.451263906815861 0.0283387250173031 -0.116898268772958 0.527375989496142 miRNATAP -0.235327399772149 0.000238652645739085 NA NA NA hsa-miR-146b-5p TEAD3 1.547491371264 6.06614361290688e-08 -0.116898268772958 0.527375989496142 miRanda -0.142778774438711 0.00126225036371349 NA NA NA hsa-miR-26b-5p TEAD3 -0.301646326928219 0.160081421968103 -0.116898268772958 0.527375989496142 miRNAWalker2_validate -0.225146274136713 0.000250523844612804 NA NA NA hsa-miR-339-5p TEAD3 0.770566566962108 0.00816529093411862 -0.116898268772958 0.527375989496142 miRanda -0.186463146612209 2.50125425727622e-05 NA NA NA hsa-miR-532-3p TEAD3 0.552364451472481 0.0975490365586023 -0.116898268772958 0.527375989496142 miRNATAP -0.14649838854666 0.000167289269714071 NA NA NA hsa-miR-590-3p TEAD3 1.11654983899947 0.000160782154924864 -0.116898268772958 0.527375989496142 miRNATAP -0.149473122557788 0.000584285816492674 NA NA NA hsa-miR-139-5p TGFB1 -1.83374360776637 1.22019901002824e-09 0.921978024389205 0.015443067273438 miRanda -0.231228229661 0.00779949032347728 NA NA NA hsa-miR-29b-3p TGFB1 -0.230693226193598 0.367461626035234 0.921978024389205 0.015443067273438 miRTarBase -0.456958304413375 1.70622144738106e-05 NA NA NA hsa-miR-141-3p TGFB2 1.45548825076434 0.00115958850961764 0.531711555933475 0.237271821958403 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.310711996035385 7.80220336778334e-06 NA NA NA hsa-miR-148a-3p TGFB2 -1.53721533763578 3.55533747293117e-05 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.220405364068209 0.00926503682050518 NA NA NA hsa-miR-148b-3p TGFB2 0.295175884456199 0.17466422420702 0.531711555933475 0.237271821958403 MirTarget -0.467759048012148 0.00176540723814519 NA NA NA hsa-miR-200a-3p TGFB2 0.717826667295984 0.193912116506827 0.531711555933475 0.237271821958403 MirTarget;miRNATAP -0.252010151933484 9.49127408816544e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.44736908507496 0.0394116388736904 0.531711555933475 0.237271821958403 MirTarget -0.165925482602356 0.000218164630138837 NA NA NA hsa-miR-32-3p TGFB2 0.583525764322974 0.11837203008551 0.531711555933475 0.237271821958403 mirMAP -0.25717146688254 0.00779413036125543 NA NA NA hsa-miR-330-3p TGFB2 0.798460296022179 0.00746538156533435 0.531711555933475 0.237271821958403 miRNATAP -0.296195247581737 0.00574751539933769 NA NA NA hsa-miR-33a-3p TGFB2 0.347011402017138 0.321709379745392 0.531711555933475 0.237271821958403 MirTarget;mirMAP -0.39918681868845 2.86864367014074e-05 NA NA NA hsa-miR-375 TGFB2 -2.94506033785642 0.00570147601654791 0.531711555933475 0.237271821958403 miRNAWalker2_validate -0.135378292973885 3.38653961690956e-06 NA NA NA hsa-miR-429 TGFB2 1.40182602301928 0.00900426780286475 0.531711555933475 0.237271821958403 miRNATAP -0.282945695650806 1.02668418456713e-06 NA NA NA hsa-let-7f-1-3p TGFB3 1.28704406797397 1.17954701106157e-06 -1.10894161909252 0.00498726268551547 MirTarget -0.272732273807511 0.00950753209568666 NA NA NA hsa-miR-10a-5p TGFB3 -0.470861534765518 0.148803248989189 -1.10894161909252 0.00498726268551547 miRNAWalker2_validate -0.277127145258827 0.00143360908543031 NA NA NA hsa-miR-151a-5p TGFB3 1.24363461949586 2.18236940049108e-07 -1.10894161909252 0.00498726268551547 MirTarget -0.661467214905873 3.42539039149492e-09 NA NA NA hsa-miR-26b-3p TGFB3 -0.0103961389461977 0.965770899625511 -1.10894161909252 0.00498726268551547 MirTarget -0.511617229426091 1.24500682090535e-05 NA NA NA hsa-miR-29a-3p TGFB3 -0.113012156986374 0.615005009685815 -1.10894161909252 0.00498726268551547 miRNAWalker2_validate -0.395874477357522 0.00201300163223496 NA NA NA hsa-miR-29b-3p TGFB3 -0.230693226193598 0.367461626035234 -1.10894161909252 0.00498726268551547 miRTarBase -0.379512133029508 0.000666754329763779 NA NA NA hsa-miR-338-5p TGFB3 -1.19659203838734 0.0100316010080496 -1.10894161909252 0.00498726268551547 PITA -0.236666190238514 7.75982569882353e-05 NA NA NA hsa-miR-590-3p TGFB3 1.11654983899947 0.000160782154924864 -1.10894161909252 0.00498726268551547 miRanda -0.312543185476898 0.000937918421040375 NA NA NA hsa-miR-629-3p TGFB3 1.40326397107309 9.7803063526732e-05 -1.10894161909252 0.00498726268551547 MirTarget -0.252264250229092 0.00108443910675355 NA NA NA hsa-miR-101-3p TGFBR1 -0.451263906815861 0.0283387250173031 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;miRNATAP -0.334479809747145 1.26739295835297e-05 NA NA NA hsa-miR-126-5p TGFBR1 0.41765430251855 0.0753161203651532 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.196953631979334 0.00365598115607916 NA NA NA hsa-miR-128-3p TGFBR1 0.98280381420517 5.77641850797209e-05 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;miRTarBase -0.244707904105477 0.000113112751777729 NA NA NA hsa-miR-130b-3p TGFBR1 1.32714007211004 4.78676252285191e-05 -0.251712186913126 0.256800460803047 miRNATAP -0.1828131710731 0.000100953415159321 NA NA NA hsa-miR-140-5p TGFBR1 0.208193069681326 0.303002433893804 -0.251712186913126 0.256800460803047 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.231595932892087 0.00360519586226147 NA NA NA hsa-miR-142-5p TGFBR1 1.55592486377018 6.69269968016779e-06 -0.251712186913126 0.256800460803047 mirMAP -0.145948144144052 0.00101240741188477 NA NA NA hsa-miR-32-3p TGFBR1 0.583525764322974 0.11837203008551 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.12860507498816 0.006711968086731 NA NA NA hsa-miR-330-3p TGFBR1 0.798460296022179 0.00746538156533435 -0.251712186913126 0.256800460803047 mirMAP;miRNATAP -0.202440596846935 0.000103947872399532 NA NA NA hsa-miR-429 TGFBR1 1.40182602301928 0.00900426780286475 -0.251712186913126 0.256800460803047 miRanda;miRNATAP -0.103531890165161 0.000330036442446001 NA NA NA hsa-miR-769-5p TGFBR1 1.14821899306381 1.27143750879772e-06 -0.251712186913126 0.256800460803047 PITA;miRNATAP -0.21341868517347 0.00105603441804849 NA NA NA hsa-miR-106a-5p TGFBR2 -0.173255688252641 0.642872703263671 -1.33119725044149 0.000132508513351042 miRTarBase;miRNATAP -0.226320359125897 0.00077804442165382 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 1.70863907461894 2.04074794107142e-08 -1.33119725044149 0.000132508513351042 miRNATAP -0.400888260139363 2.94525271112196e-07 NA NA NA hsa-miR-130a-3p TGFBR2 0.146223920674657 0.633739795905839 -1.33119725044149 0.000132508513351042 miRNATAP -0.427886145251413 1.09487440025064e-07 NA NA NA hsa-miR-130b-3p TGFBR2 1.32714007211004 4.78676252285191e-05 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRNATAP -0.329348888087832 1.10224858433269e-05 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 1.65862087862483 8.45603406215941e-08 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.344035070546453 9.8957948491363e-06 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 2.20211504140984 1.78678887916334e-09 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate -0.233498338363247 0.000370839906771444 NA NA NA hsa-miR-19b-3p TGFBR2 0.759818275708988 0.00652779573186786 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRNATAP -0.245361262248594 0.00658859699698292 NA NA NA hsa-miR-20a-5p TGFBR2 1.4503375861709 5.7813456424762e-07 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.323999105962337 0.000116784197797681 NA NA NA hsa-miR-23a-3p TGFBR2 1.10685926969665 3.16223452471768e-08 -1.33119725044149 0.000132508513351042 miRNATAP -0.801195046416303 1.19427456267555e-11 NA NA NA hsa-miR-23b-3p TGFBR2 -0.286465516491361 0.18664668472995 -1.33119725044149 0.000132508513351042 miRNATAP -0.449425647160368 0.00012654828770299 NA NA NA hsa-miR-301a-3p TGFBR2 1.44721900431161 6.35068481036652e-06 -1.33119725044149 0.000132508513351042 miRNATAP -0.365169880396282 1.34130255394917e-06 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320b TGFBR2 1.11183660885284 0.000497971211648503 -1.33119725044149 0.000132508513351042 miRanda;miRNATAP -0.260382110270946 0.000825284330358438 NA NA NA hsa-miR-335-3p TGFBR2 2.5197689063267 2.20084506976733e-09 -1.33119725044149 0.000132508513351042 mirMAP -0.211651995421728 0.000195672473367393 NA NA NA hsa-miR-33a-3p TGFBR2 0.347011402017138 0.321709379745392 -1.33119725044149 0.000132508513351042 mirMAP -0.279930982457639 0.000205915700583289 NA NA NA hsa-miR-34c-5p TGFBR2 2.20632574870337 0.000379662996168678 -1.33119725044149 0.000132508513351042 miRanda -0.281900640241328 9.20313386230208e-14 NA NA NA hsa-miR-590-3p TGFBR2 1.11654983899947 0.000160782154924864 -1.33119725044149 0.000132508513351042 miRanda -0.270662071596108 0.00128102617583729 NA NA NA hsa-miR-590-5p TGFBR2 1.04171442093217 0.000272475544954865 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.429974806304296 4.84095482585984e-07 NA NA NA hsa-miR-9-3p TGFBR2 0.330346058941473 0.541111939982661 -1.33119725044149 0.000132508513351042 miRNATAP -0.24679581591473 1.8898130718455e-07 NA NA NA hsa-miR-9-5p TGFBR2 -0.195328736653048 0.761470692992178 -1.33119725044149 0.000132508513351042 miRNATAP -0.190654791604636 6.1026585044985e-07 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 1.2209325870225 6.8757197708107e-06 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate -0.454055744142823 3.73583294489171e-07 NA NA NA hsa-miR-93-5p TGFBR2 1.7515174434778 1.59386482413883e-08 -1.33119725044149 0.000132508513351042 miRNAWalker2_validate;miRNATAP -0.38955660370349 3.98089061392563e-07 NA NA NA hsa-miR-10a-5p TP73 -0.470861534765518 0.148803248989189 3.13334835059042 2.43758243274273e-06 mirMAP -0.7618169766012 1.80321688089474e-07 NA NA NA hsa-miR-192-5p TP73 0.0809146624034405 0.941057093528709 3.13334835059042 2.43758243274273e-06 mirMAP -0.339324490217586 1.32283206800023e-16 NA NA NA hsa-miR-194-3p TP73 0.259420201261466 0.821811295418686 3.13334835059042 2.43758243274273e-06 mirMAP -0.307721078134838 1.0865169460496e-14 NA NA NA hsa-miR-361-3p TP73 -0.126462931388735 0.566052688733137 3.13334835059042 2.43758243274273e-06 MirTarget -0.698422152270084 0.00186296102029691 NA NA NA hsa-miR-7-5p TP73 1.63575693499363 0.0124424214624534 3.13334835059042 2.43758243274273e-06 mirMAP -0.266650599567726 0.000512113251627234 NA NA NA hsa-miR-378c WNT10A -1.27752074861415 2.73676010235611e-05 2.2701547287338 0.00127347331644124 MirTarget;miRNATAP -0.660228950508148 4.82267723929998e-05 NA NA NA hsa-miR-188-5p WNT10B 1.35426907033843 0.00038346077691455 -0.034076867858473 0.953849828888768 PITA -0.345575013490546 0.00138072762179139 NA NA NA hsa-miR-335-5p WNT10B 1.59953351087307 5.56170899867314e-05 -0.034076867858473 0.953849828888768 miRNAWalker2_validate -0.3048640067492 0.00322033380481142 NA NA NA hsa-miR-338-3p WNT10B -0.959276231066179 0.0191473351014091 -0.034076867858473 0.953849828888768 miRanda -0.414771031435559 3.704862350859e-05 NA NA NA hsa-miR-139-5p WNT2 -1.83374360776637 1.22019901002824e-09 3.70377612421499 2.01815591609684e-09 miRanda -1.16666361528028 4.63620810615476e-18 NA NA NA hsa-miR-361-3p WNT2 -0.126462931388735 0.566052688733137 3.70377612421499 2.01815591609684e-09 MirTarget -0.635921256518215 0.00275035843201281 NA NA NA hsa-miR-186-5p WNT2B 0.149964130725901 0.434709542998771 -0.857505868222388 0.116219083684247 mirMAP -0.960298005730627 2.68816984187597e-06 NA NA NA hsa-miR-32-3p WNT2B 0.583525764322974 0.11837203008551 -0.857505868222388 0.116219083684247 mirMAP -0.405385684639584 0.00051527357241527 NA NA NA hsa-miR-323b-3p WNT2B 1.13581624461921 0.0214847831286342 -0.857505868222388 0.116219083684247 MirTarget -0.235063379273332 0.00799604830750861 NA NA NA hsa-miR-429 WNT2B 1.40182602301928 0.00900426780286475 -0.857505868222388 0.116219083684247 miRNATAP -0.209663852684724 0.00349237315414342 NA NA NA hsa-miR-454-3p WNT2B 0.625199142970745 0.0134890997402741 -0.857505868222388 0.116219083684247 MirTarget -0.44590147231517 0.00393132643305126 NA NA NA hsa-miR-146a-5p WNT3 1.82051649415508 2.03651725047679e-05 2.24456485218643 2.58971950324471e-07 MirTarget -0.207494212976049 0.00466526765145484 NA NA NA hsa-miR-192-5p WNT3 0.0809146624034405 0.941057093528709 2.24456485218643 2.58971950324471e-07 miRNAWalker2_validate -0.119509167014447 3.33030976301956e-05 NA NA NA hsa-miR-361-3p WNT3A -0.126462931388735 0.566052688733137 2.57157096233085 0.0131142473042257 MirTarget -1.61207561567763 1.76825683834461e-06 NA NA NA hsa-miR-423-5p WNT3A 0.832613878736338 0.000791321227103338 2.57157096233085 0.0131142473042257 MirTarget -1.06775787619661 0.000333229953339482 NA NA NA hsa-miR-140-3p WNT5A -0.296251775392129 0.127539826012144 1.41889465887496 0.00302272108132253 MirTarget;miRNATAP -0.654997547844657 0.000272516279902339 NA NA NA hsa-miR-148a-5p WNT5A -0.69329616490858 0.0793012233740369 1.41889465887496 0.00302272108132253 mirMAP -0.266432697712533 0.00213233612269223 NA NA NA hsa-miR-186-5p WNT5A 0.149964130725901 0.434709542998771 1.41889465887496 0.00302272108132253 miRNAWalker2_validate;mirMAP;miRNATAP -0.596923529656949 0.00113609892095247 NA NA NA hsa-miR-2110 WNT5A 0.759864042760204 0.0723961390557655 1.41889465887496 0.00302272108132253 MirTarget -0.233877228710552 0.00444047447373778 NA NA NA hsa-miR-29a-5p WNT5A 0.585084040404152 0.023014129158495 1.41889465887496 0.00302272108132253 mirMAP -0.458967614840154 0.000602375776214386 NA NA NA hsa-miR-30a-3p WNT5A -1.73205137750899 3.2425754511091e-07 1.41889465887496 0.00302272108132253 mirMAP -0.280674702827158 0.00442239689083578 NA NA NA hsa-miR-30a-5p WNT5A -1.71922855140016 3.20574349285256e-07 1.41889465887496 0.00302272108132253 miRNAWalker2_validate;mirMAP -0.30560196566196 0.00207001162461839 NA NA NA hsa-miR-30b-5p WNT5A -0.430720743745757 0.0593564057320791 1.41889465887496 0.00302272108132253 mirMAP -0.425807828312639 0.00526169426726682 NA NA NA hsa-miR-30c-5p WNT5A -0.983130268805942 4.60419218706127e-05 1.41889465887496 0.00302272108132253 mirMAP -0.441333932103179 0.0017917746829392 NA NA NA hsa-miR-30d-3p WNT5A -0.545113326540761 0.0433733076874155 1.41889465887496 0.00302272108132253 mirMAP -0.420494750254843 0.000995090928789905 NA NA NA hsa-miR-30d-5p WNT5A -0.5492586056147 0.0140125082460125 1.41889465887496 0.00302272108132253 mirMAP -0.485615482740843 0.00175018462113529 NA NA NA hsa-miR-326 WNT5A -0.429748586406214 0.2629894124021 1.41889465887496 0.00302272108132253 miRanda -0.338021912325719 0.000172032350996894 NA NA NA hsa-miR-330-5p WNT5A 0.488365986827708 0.0512207630808233 1.41889465887496 0.00302272108132253 miRanda -0.360290139732328 0.00941314185696927 NA NA NA hsa-miR-375 WNT5A -2.94506033785642 0.00570147601654791 1.41889465887496 0.00302272108132253 miRNATAP -0.151859982937763 1.13834427953838e-06 NA NA NA hsa-miR-577 WNT5A 0.911619788986754 0.2256062124148 1.41889465887496 0.00302272108132253 mirMAP;miRNATAP -0.158155731877324 0.000655709824150159 NA NA NA hsa-miR-7-1-3p WNT5A 0.709309110750947 0.0412301737463194 1.41889465887496 0.00302272108132253 mirMAP -0.431985130260792 9.26141562033071e-06 NA NA NA hsa-miR-185-5p WNT5B 1.14351510556643 1.07346945085714e-08 -0.551387286059568 0.216795813752651 miRNAWalker2_validate -0.477964408259972 0.00215676072187357 NA NA NA hsa-miR-107 WNT7A 0.904627575346218 4.67936495073904e-05 2.66548027730531 0.0206093992649559 MirTarget;miRanda -1.51723109387951 3.36678242988304e-05 NA NA NA hsa-miR-3614-5p WNT7A 1.10426689932954 0.00706308396674599 2.66548027730531 0.0206093992649559 mirMAP -0.670760428767663 0.000880251008673417 NA NA NA hsa-miR-592 WNT7A 0.779567202789068 0.204498177014474 2.66548027730531 0.0206093992649559 mirMAP -0.683379563079839 1.24784262124799e-06 NA NA NA hsa-miR-10a-5p WNT7B -0.470861534765518 0.148803248989189 4.70102767585379 9.87481269172066e-07 mirMAP -1.12406593953887 1.01980893803914e-07 NA NA NA hsa-miR-30a-5p WNT7B -1.71922855140016 3.20574349285256e-07 4.70102767585379 9.87481269172066e-07 miRNATAP -0.776866746798796 0.000118836244523581 NA NA NA hsa-miR-30c-5p WNT7B -0.983130268805942 4.60419218706127e-05 4.70102767585379 9.87481269172066e-07 miRNATAP -1.2809545535297 7.33213481342116e-06 NA NA NA hsa-miR-30d-5p WNT7B -0.5492586056147 0.0140125082460125 4.70102767585379 9.87481269172066e-07 miRNATAP -1.66887517128546 7.42254813517495e-08 NA NA NA hsa-miR-326 WNT7B -0.429748586406214 0.2629894124021 4.70102767585379 9.87481269172066e-07 MirTarget;miRanda -1.12743206916706 2.59670466792877e-10 NA NA NA hsa-miR-423-5p WNT7B 0.832613878736338 0.000791321227103338 4.70102767585379 9.87481269172066e-07 mirMAP -0.958199286004849 0.000695154380109559 NA NA NA hsa-miR-491-5p WNT7B -0.693578126269305 0.0313646742330058 4.70102767585379 9.87481269172066e-07 mirMAP -0.671080735204415 0.00265397907881839 NA NA NA hsa-miR-502-5p WNT7B -0.260297419808178 0.520453580478988 4.70102767585379 9.87481269172066e-07 miRNATAP -0.714509401537533 3.86992594275062e-05 NA NA NA hsa-miR-625-5p WNT7B 0.537211086526376 0.203801009380384 4.70102767585379 9.87481269172066e-07 mirMAP -0.940290950988033 6.55498206076764e-09 NA NA NA hsa-miR-664a-5p WNT7B -0.134698715850215 0.624350535385503 4.70102767585379 9.87481269172066e-07 MirTarget -0.988215406398432 0.000146476931556221 NA NA NA hsa-miR-140-3p WNT9A -0.296251775392129 0.127539826012144 -0.840165024905675 0.243988271559469 mirMAP -1.35742392216201 2.82042922395005e-07 NA NA NA hsa-miR-148a-3p WNT9A -1.53721533763578 3.55533747293117e-05 -0.840165024905675 0.243988271559469 mirMAP -0.620008087787986 3.30742469072754e-06 NA NA NA hsa-miR-148b-3p WNT9A 0.295175884456199 0.17466422420702 -0.840165024905675 0.243988271559469 mirMAP -1.44084295430079 4.65243370226952e-10 NA NA NA hsa-miR-15a-5p WNT9A 1.03783090449383 7.40334108980898e-07 -0.840165024905675 0.243988271559469 mirMAP -0.954111075830453 7.11883866960814e-05 NA NA NA hsa-miR-16-5p WNT9A 1.00515772948091 5.33912942007619e-06 -0.840165024905675 0.243988271559469 mirMAP -0.767096904563146 0.000847330187242408 NA NA NA hsa-miR-32-5p WNT9A 0.415247682945382 0.106458022460373 -0.840165024905675 0.243988271559469 mirMAP -0.890299552267469 7.30940663393152e-06 NA NA NA hsa-miR-330-3p WNT9A 0.798460296022179 0.00746538156533435 -0.840165024905675 0.243988271559469 mirMAP -0.580288711807054 0.0006995792050726 NA NA NA hsa-miR-335-5p WNT9A 1.59953351087307 5.56170899867314e-05 -0.840165024905675 0.243988271559469 miRNAWalker2_validate -0.729310029443379 2.83628090884829e-09 NA NA NA hsa-miR-532-3p WNT9A 0.552364451472481 0.0975490365586023 -0.840165024905675 0.243988271559469 mirMAP -1.23338189351498 3.54157493514412e-18 NA NA NA hsa-miR-103a-3p WTIP 0.840525139266028 5.83536475789158e-07 -0.966825197278602 0.00385042855876837 mirMAP -0.581401499581084 4.04117114281355e-05 NA NA NA hsa-miR-106b-5p WTIP 1.70863907461894 2.04074794107142e-08 -0.966825197278602 0.00385042855876837 mirMAP -0.217284719776335 0.00436845233851738 NA NA NA hsa-miR-107 WTIP 0.904627575346218 4.67936495073904e-05 -0.966825197278602 0.00385042855876837 mirMAP -0.396454555055442 0.000208917870000436 NA NA NA hsa-miR-135b-5p WTIP 4.09156383496059 1.32294295002438e-12 -0.966825197278602 0.00385042855876837 mirMAP -0.151830110136979 8.49039914959804e-05 NA NA NA hsa-miR-141-3p WTIP 1.45548825076434 0.00115958850961764 -0.966825197278602 0.00385042855876837 mirMAP -0.269516198113732 1.75742321978339e-07 NA NA NA hsa-miR-148b-5p WTIP 1.04409494910362 0.00195860954157389 -0.966825197278602 0.00385042855876837 mirMAP -0.217085350305822 0.00208666205057505 NA NA NA hsa-miR-15a-5p WTIP 1.03783090449383 7.40334108980898e-07 -0.966825197278602 0.00385042855876837 mirMAP -0.515590946411893 3.67801347767224e-06 NA NA NA hsa-miR-15b-5p WTIP 1.62046407540723 5.42152621571078e-09 -0.966825197278602 0.00385042855876837 mirMAP -0.346364953252385 2.70483381371969e-05 NA NA NA hsa-miR-16-5p WTIP 1.00515772948091 5.33912942007619e-06 -0.966825197278602 0.00385042855876837 mirMAP -0.358801599465301 0.000833175687965146 NA NA NA hsa-miR-17-3p WTIP 1.31126744284937 3.24768335024185e-07 -0.966825197278602 0.00385042855876837 mirMAP -0.398165346935353 1.019361386369e-05 NA NA NA hsa-miR-185-5p WTIP 1.14351510556643 1.07346945085714e-08 -0.966825197278602 0.00385042855876837 mirMAP -0.45215725257412 0.000108273228839015 NA NA NA hsa-miR-192-3p WTIP 0.355565421687399 0.74117031340037 -0.966825197278602 0.00385042855876837 mirMAP -0.12695701121701 6.0852614289173e-09 NA NA NA hsa-miR-194-5p WTIP -0.127742909829168 0.906065815804667 -0.966825197278602 0.00385042855876837 mirMAP -0.12265685811809 9.73436417501909e-09 NA NA NA hsa-miR-200a-3p WTIP 0.717826667295984 0.193912116506827 -0.966825197278602 0.00385042855876837 mirMAP -0.278863555079483 1.39536925863832e-11 NA NA NA hsa-miR-20a-5p WTIP 1.4503375861709 5.7813456424762e-07 -0.966825197278602 0.00385042855876837 mirMAP -0.28825554648365 0.000331336429483937 NA NA NA hsa-miR-29b-3p WTIP -0.230693226193598 0.367461626035234 -0.966825197278602 0.00385042855876837 mirMAP -0.255595588474762 0.00712313886066486 NA NA NA hsa-miR-32-5p WTIP 0.415247682945382 0.106458022460373 -0.966825197278602 0.00385042855876837 mirMAP -0.326623225536353 0.000489477080191535 NA NA NA hsa-miR-335-5p WTIP 1.59953351087307 5.56170899867314e-05 -0.966825197278602 0.00385042855876837 mirMAP -0.206021852263408 0.000485506391449882 NA NA NA hsa-miR-33b-5p WTIP 0.267227362818466 0.614814331176942 -0.966825197278602 0.00385042855876837 mirMAP -0.175997956131913 0.00258051725413166 NA NA NA hsa-miR-34a-5p WTIP 0.794251341270032 0.00024017386701179 -0.966825197278602 0.00385042855876837 mirMAP -0.34256781305698 0.0020370982980167 NA NA NA hsa-miR-3615 WTIP 1.25850728223629 0.000102643804657077 -0.966825197278602 0.00385042855876837 mirMAP -0.216463538555489 0.00303228854276394 NA NA NA hsa-miR-362-5p WTIP -0.354508685915981 0.354912078595613 -0.966825197278602 0.00385042855876837 mirMAP -0.196361879635211 0.00170516228272987 NA NA NA hsa-miR-425-5p WTIP 1.13924952403101 0.000255357546232931 -0.966825197278602 0.00385042855876837 mirMAP -0.229445937900176 0.00258525992047601 NA NA NA hsa-miR-550a-5p WTIP 2.27360629906903 2.14504977831873e-07 -0.966825197278602 0.00385042855876837 mirMAP -0.172587515230379 0.00114242671691825 NA NA NA hsa-miR-589-5p WTIP 0.702695092403762 0.00395772685954799 -0.966825197278602 0.00385042855876837 mirMAP -0.358317110916029 0.00026098538512913 NA NA NA hsa-miR-625-5p WTIP 0.537211086526376 0.203801009380384 -0.966825197278602 0.00385042855876837 mirMAP -0.262922629957113 2.69707235501484e-06 NA NA NA hsa-miR-7-5p WTIP 1.63575693499363 0.0124424214624534 -0.966825197278602 0.00385042855876837 mirMAP -0.189722014076562 3.40310493096266e-07 NA NA NA hsa-miR-92a-1-5p WTIP 1.89098984312485 1.38098912842682e-06 -0.966825197278602 0.00385042855876837 mirMAP -0.20530997224767 0.000538765119733272 NA NA NA hsa-miR-92a-3p WTIP 1.2209325870225 6.8757197708107e-06 -0.966825197278602 0.00385042855876837 mirMAP -0.30362967823376 0.00045405768728387 NA NA NA hsa-let-7a-3p WWC1 0.503048155002889 0.0411145454335299 -0.592056803113965 0.0794802830428718 MirTarget;miRNATAP -0.270250479537563 0.00614055890731554 NA NA NA hsa-miR-130a-3p WWC1 0.146223920674657 0.633739795905839 -0.592056803113965 0.0794802830428718 mirMAP -0.32655728556371 2.82619849890385e-05 NA NA NA hsa-miR-143-5p WWC1 -0.452341959646033 0.125356933437373 -0.592056803113965 0.0794802830428718 mirMAP -0.277244575353251 0.00067811659565 NA NA NA hsa-miR-483-3p WWC1 1.09937307882201 0.104408487470684 -0.592056803113965 0.0794802830428718 MirTarget;PITA -0.123437603097491 0.00748599245099009 NA NA NA hsa-miR-744-3p WWC1 1.40439584998788 0.000973603203532439 -0.592056803113965 0.0794802830428718 mirMAP -0.210710505427981 0.000145878768541 NA NA NA hsa-miR-130b-5p WWTR1 0.701350393759937 0.0510142718395002 -0.709942068699701 0.0386834137440413 MirTarget;miRNATAP -0.240819419032948 0.00037658258649578 NA NA NA hsa-miR-141-3p WWTR1 1.45548825076434 0.00115958850961764 -0.709942068699701 0.0386834137440413 MirTarget;TargetScan;miRNATAP -0.249175449194712 2.63458006731948e-06 NA NA NA hsa-miR-17-3p WWTR1 1.31126744284937 3.24768335024185e-07 -0.709942068699701 0.0386834137440413 MirTarget -0.519003997216374 1.01033386569955e-08 NA NA NA hsa-miR-18a-5p WWTR1 2.20211504140984 1.78678887916334e-09 -0.709942068699701 0.0386834137440413 miRNAWalker2_validate -0.359539569186215 7.18971852746171e-09 NA NA NA hsa-miR-1976 WWTR1 0.923172654386147 0.000118514313506673 -0.709942068699701 0.0386834137440413 MirTarget -0.565319864357834 9.92921104513988e-09 NA NA NA hsa-miR-200a-3p WWTR1 0.717826667295984 0.193912116506827 -0.709942068699701 0.0386834137440413 MirTarget;miRNATAP -0.24905203620633 5.7511653180847e-09 NA NA NA hsa-miR-29a-3p WWTR1 -0.113012156986374 0.615005009685815 -0.709942068699701 0.0386834137440413 miRNATAP -0.352206272529018 0.00147662831438618 NA NA NA hsa-miR-29a-5p WWTR1 0.585084040404152 0.023014129158495 -0.709942068699701 0.0386834137440413 mirMAP -0.424238903539386 6.85177160351171e-06 NA NA NA hsa-miR-29b-3p WWTR1 -0.230693226193598 0.367461626035234 -0.709942068699701 0.0386834137440413 miRNATAP -0.341734813724727 0.000388965490105409 NA NA NA hsa-miR-30b-5p WWTR1 -0.430720743745757 0.0593564057320791 -0.709942068699701 0.0386834137440413 MirTarget;mirMAP -0.394293259955518 0.00026011516675069 NA NA NA hsa-miR-30d-5p WWTR1 -0.5492586056147 0.0140125082460125 -0.709942068699701 0.0386834137440413 MirTarget;mirMAP -0.459398445154899 2.71028461540459e-05 NA NA NA hsa-miR-32-3p WWTR1 0.583525764322974 0.11837203008551 -0.709942068699701 0.0386834137440413 mirMAP -0.223714867871273 0.00242081540600409 NA NA NA hsa-miR-320a WWTR1 0.593888711838028 0.011897419390526 -0.709942068699701 0.0386834137440413 miRanda;miRNATAP -0.303773605182709 0.00367278475838704 NA NA NA hsa-miR-320b WWTR1 1.11183660885284 0.000497971211648503 -0.709942068699701 0.0386834137440413 miRanda;miRNATAP -0.261916850570801 0.000536967693309259 NA NA NA hsa-miR-320c WWTR1 0.455072851945474 0.240613785444485 -0.709942068699701 0.0386834137440413 miRanda;miRNATAP -0.21624657669625 0.0031573808463485 NA NA NA hsa-miR-335-3p WWTR1 2.5197689063267 2.20084506976733e-09 -0.709942068699701 0.0386834137440413 MirTarget -0.285687752830936 1.44158164280819e-07 NA NA NA hsa-miR-335-5p WWTR1 1.59953351087307 5.56170899867314e-05 -0.709942068699701 0.0386834137440413 miRNAWalker2_validate -0.291738413203698 9.02001729027364e-07 NA NA NA hsa-miR-3607-3p WWTR1 0.522750552658156 0.0842510989344654 -0.709942068699701 0.0386834137440413 mirMAP -0.23724315820589 0.00348502896056807 NA NA NA hsa-miR-501-5p WWTR1 0.266919328110625 0.454779001968586 -0.709942068699701 0.0386834137440413 mirMAP -0.376684609332654 1.71585439984887e-08 NA NA NA hsa-miR-576-5p WWTR1 0.625714137488957 0.0417100301848969 -0.709942068699701 0.0386834137440413 MirTarget;mirMAP -0.264802733646561 0.000880535670809435 NA NA NA hsa-miR-582-5p WWTR1 -0.448820171762719 0.134615974001015 -0.709942068699701 0.0386834137440413 MirTarget;PITA -0.23051696233038 0.00500654443900169 NA NA NA hsa-miR-590-3p WWTR1 1.11654983899947 0.000160782154924864 -0.709942068699701 0.0386834137440413 MirTarget;miRanda;mirMAP -0.352509968413422 1.30420975652068e-05 NA NA NA hsa-miR-624-5p WWTR1 1.03467956701702 0.0010908013402586 -0.709942068699701 0.0386834137440413 MirTarget -0.224089458072777 0.00587585397656016 NA NA NA hsa-miR-627-5p WWTR1 0.957170497954686 0.005243019536732 -0.709942068699701 0.0386834137440413 MirTarget -0.212123663856699 0.00340903209671154 NA NA NA hsa-miR-7-1-3p WWTR1 0.709309110750947 0.0412301737463194 -0.709942068699701 0.0386834137440413 mirMAP -0.468415901902391 2.54643675423339e-12 NA NA NA hsa-miR-93-3p WWTR1 1.88964231421793 1.80075645722786e-08 -0.709942068699701 0.0386834137440413 MirTarget -0.266148237204513 0.000141018962759835 NA NA NA hsa-miR-16-2-3p YAP1 1.8048179609245 2.83095715136409e-09 -0.327463203893452 0.138898553726555 mirMAP -0.138623133516033 0.00536006100559617 NA NA NA hsa-miR-361-3p YAP1 -0.126462931388735 0.566052688733137 -0.327463203893452 0.138898553726555 MirTarget;PITA -0.224326200444648 0.00195955215738712 NA NA NA hsa-miR-484 YAP1 0.71327898984355 0.00233605130771196 -0.327463203893452 0.138898553726555 PITA;miRNATAP -0.181215670367981 0.00712304182720249 NA NA NA hsa-miR-532-5p YAP1 0.313080805824184 0.252248939356301 -0.327463203893452 0.138898553726555 PITA -0.164381564776352 0.00453319496213779 NA NA NA hsa-miR-625-5p YAP1 0.537211086526376 0.203801009380384 -0.327463203893452 0.138898553726555 MirTarget -0.11599082896527 0.00183310192169891 NA NA NA hsa-miR-7-1-3p YAP1 0.709309110750947 0.0412301737463194 -0.327463203893452 0.138898553726555 mirMAP -0.159839373905797 0.000366628368038538 NA NA NA hsa-miR-218-5p YWHAB -0.987730614742492 0.0108295837207062 0.560953273192444 3.96438720523435e-05 MirTarget;miRNATAP -0.132643605810655 5.34245751955568e-08 NA NA NA hsa-miR-28-3p YWHAB -0.730670593501133 0.000351503999708671 0.560953273192444 3.96438720523435e-05 mirMAP -0.201074933049334 2.31268016134537e-05 NA NA NA hsa-miR-29b-2-5p YWHAE -1.7015307882027 2.84239251703401e-10 0.589666273640299 0.000303774555361019 MirTarget -0.283442585158459 6.04869989497828e-13 NA NA NA hsa-miR-30a-3p YWHAE -1.73205137750899 3.2425754511091e-07 0.589666273640299 0.000303774555361019 miRNAWalker2_validate;MirTarget;miRNATAP -0.122887316569407 0.000220217281793117 NA NA NA hsa-miR-30a-5p YWHAE -1.71922855140016 3.20574349285256e-07 0.589666273640299 0.000303774555361019 miRNAWalker2_validate -0.162000089779657 9.7810828573082e-07 NA NA NA hsa-miR-139-5p YWHAG -1.83374360776637 1.22019901002824e-09 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRanda;miRNATAP -0.233897074977505 1.76624963351128e-07 NA NA NA hsa-miR-140-3p YWHAG -0.296251775392129 0.127539826012144 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRNATAP -0.378974206830825 3.19734199541644e-07 NA NA NA hsa-miR-148a-3p YWHAG -1.53721533763578 3.55533747293117e-05 0.786064999170599 8.42926791804072e-05 mirMAP -0.207644440245434 1.84352771112896e-08 NA NA NA hsa-miR-148b-3p YWHAG 0.295175884456199 0.17466422420702 0.786064999170599 8.42926791804072e-05 mirMAP -0.185299344730775 0.00603097910246455 NA NA NA hsa-miR-181c-5p YWHAG 0.336826967681288 0.112932307913601 0.786064999170599 8.42926791804072e-05 MirTarget;miRNATAP -0.25588328816477 0.000187835020300278 NA NA NA hsa-miR-217 YWHAG -0.0121404731225336 0.980818372851502 0.786064999170599 8.42926791804072e-05 MirTarget;PITA;miRanda;miRNATAP -0.147034916555345 1.2228899839513e-07 NA NA NA hsa-miR-30a-5p YWHAG -1.71922855140016 3.20574349285256e-07 0.786064999170599 8.42926791804072e-05 miRNATAP -0.196811149472458 1.43906773606096e-06 NA NA NA hsa-miR-30b-5p YWHAG -0.430720743745757 0.0593564057320791 0.786064999170599 8.42926791804072e-05 miRNATAP -0.257903077785551 4.47785555025729e-05 NA NA NA hsa-miR-30c-5p YWHAG -0.983130268805942 4.60419218706127e-05 0.786064999170599 8.42926791804072e-05 miRNATAP -0.220075232527337 0.000185668060209576 NA NA NA hsa-miR-30d-5p YWHAG -0.5492586056147 0.0140125082460125 0.786064999170599 8.42926791804072e-05 miRNATAP -0.213526360715379 0.00100328280019275 NA NA NA hsa-miR-338-5p YWHAG -1.19659203838734 0.0100316010080496 0.786064999170599 8.42926791804072e-05 PITA;miRNATAP -0.11095194976889 0.000280249373758779 NA NA NA hsa-miR-361-3p YWHAG -0.126462931388735 0.566052688733137 0.786064999170599 8.42926791804072e-05 miRNATAP -0.282376760792372 1.74886615897343e-05 NA NA NA hsa-miR-500a-5p YWHAG 0.00337014556047865 0.992120109131868 0.786064999170599 8.42926791804072e-05 MirTarget;miRNATAP -0.183877094182199 1.09597495079572e-05 NA NA NA hsa-miR-625-3p YWHAG -0.185298294014366 0.626215541224408 0.786064999170599 8.42926791804072e-05 MirTarget -0.138559000351507 0.000237647988117345 NA NA NA hsa-let-7f-5p YWHAQ 0.634633924115866 0.0344982923411787 0.332508468080446 0.0893671775677139 miRNAWalker2_validate -0.135613273474918 0.00338792114275032 NA NA NA hsa-miR-139-5p YWHAQ -1.83374360776637 1.22019901002824e-09 0.332508468080446 0.0893671775677139 MirTarget;PITA;miRanda;miRNATAP -0.149575828728304 0.000675738998730082 NA NA NA hsa-miR-140-5p YWHAQ 0.208193069681326 0.303002433893804 0.332508468080446 0.0893671775677139 miRanda -0.247121691653543 0.00040094290892181 NA NA NA hsa-miR-195-5p YWHAQ -0.907998841926297 0.00150511564650591 0.332508468080446 0.0893671775677139 MirTarget;miRNATAP -0.172346531798579 0.000330508930253542 NA NA NA hsa-miR-497-5p YWHAQ -0.801030912431774 0.00360386743876612 0.332508468080446 0.0893671775677139 MirTarget;miRNATAP -0.190571360702168 0.000136707529898457 NA NA NA hsa-miR-125a-5p YWHAZ -0.878090699011564 0.000213630844319685 0.910846108792837 3.95356455522822e-05 miRanda -0.2963263935549 8.08143300917313e-06 NA NA NA hsa-miR-129-5p YWHAZ -2.56914016541176 2.36237896095709e-06 0.910846108792837 3.95356455522822e-05 miRanda -0.100589986472573 0.000512352503638405 NA NA NA hsa-miR-140-3p YWHAZ -0.296251775392129 0.127539826012144 0.910846108792837 3.95356455522822e-05 MirTarget;PITA;miRNATAP -0.485218364242567 2.60009968767316e-09 NA NA NA hsa-miR-195-3p YWHAZ -1.34779269408059 2.01619826639376e-05 0.910846108792837 3.95356455522822e-05 MirTarget -0.258353646708993 1.21967510972882e-07 NA NA NA hsa-miR-217 YWHAZ -0.0121404731225336 0.980818372851502 0.910846108792837 3.95356455522822e-05 miRanda -0.152196035725098 9.61806411845085e-07 NA NA NA hsa-miR-28-5p YWHAZ -0.238617853755144 0.167318538669818 0.910846108792837 3.95356455522822e-05 PITA;miRanda;miRNATAP -0.360580666571329 0.000148316235198698 NA NA NA hsa-miR-30a-5p YWHAZ -1.71922855140016 3.20574349285256e-07 0.910846108792837 3.95356455522822e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.289090361794288 6.87659241068155e-11 NA NA NA hsa-miR-30c-5p YWHAZ -0.983130268805942 4.60419218706127e-05 0.910846108792837 3.95356455522822e-05 MirTarget;miRNATAP -0.294131949452993 5.89454758802094e-06 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30e-5p YWHAZ -0.573784818166736 0.0112497802572927 0.910846108792837 3.95356455522822e-05 MirTarget;miRNATAP -0.223629791120878 0.00170925393290396 NA NA NA hsa-miR-338-5p YWHAZ -1.19659203838734 0.0100316010080496 0.910846108792837 3.95356455522822e-05 mirMAP -0.116394082658444 0.000624841952889922 NA NA NA hsa-miR-340-3p YWHAZ -0.54276408676339 0.0739694056098475 0.910846108792837 3.95356455522822e-05 miRNAWalker2_validate -0.137139821904965 0.00968831074205658 NA NA NA hsa-miR-664a-3p YWHAZ -0.83041219170254 0.000136267547251167 0.910846108792837 3.95356455522822e-05 mirMAP -0.226096100567498 0.00210502900459849 NA NA NA