miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p BMP2 0.110074064773897 0.13045815990621 -0.652254459003093 5.61382094696212e-06 miRNATAP -0.379256722539851 2.17571818580078e-05 NA NA NA hsa-miR-106b-5p BMP2 0.167096183547615 0.0497544396383451 -0.652254459003093 5.61382094696212e-06 miRNATAP -0.495934952520913 8.73117041069074e-10 NA NA NA hsa-miR-125a-5p BMP2 -0.0833349424517387 0.325440200253607 -0.652254459003093 5.61382094696212e-06 miRanda -0.992723703733736 6.48828897342937e-32 NA NA NA hsa-miR-140-5p BMP2 0.065063507103468 0.380452509211773 -0.652254459003093 5.61382094696212e-06 PITA;miRanda;miRNATAP -0.366973780990385 4.43857933735015e-05 NA NA NA hsa-miR-142-5p BMP2 0.434884875454107 0.000575570345702788 -0.652254459003093 5.61382094696212e-06 PITA;miRNATAP -0.504949000703555 4.32942094894813e-28 NA NA NA hsa-miR-26b-5p BMP2 -0.0984536538762768 0.231803769574623 -0.652254459003093 5.61382094696212e-06 miRNAWalker2_validate -0.451660670723563 3.77922021760577e-07 NA NA NA hsa-miR-335-3p BMP2 0.34540584335595 0.00043848660222294 -0.652254459003093 5.61382094696212e-06 mirMAP -0.621866878051246 1.52430883092716e-23 NA NA NA hsa-miR-335-5p BMP2 0.0938511632756978 0.336889056387694 -0.652254459003093 5.61382094696212e-06 miRNAWalker2_validate -0.418183883313767 3.76588244222327e-11 NA NA NA hsa-miR-362-3p BMP2 0.032375035235532 0.736465332563774 -0.652254459003093 5.61382094696212e-06 miRanda -0.296804089620849 3.26609540519082e-06 NA NA NA hsa-miR-369-3p BMP2 -0.153496605399658 0.296055925448078 -0.652254459003093 5.61382094696212e-06 miRNATAP -0.296206107417938 6.32326936915304e-13 NA NA NA hsa-miR-378c BMP2 0.169076160997048 0.114131854194064 -0.652254459003093 5.61382094696212e-06 miRNATAP -0.157051669415718 0.00748936653775339 NA NA NA hsa-miR-421 BMP2 -0.171573235029879 0.0518112933651029 -0.652254459003093 5.61382094696212e-06 PITA;miRanda -0.483621667743453 2.02528599501395e-12 NA NA NA hsa-miR-488-3p BMP2 -0.257955761012568 0.00280795162806256 -0.652254459003093 5.61382094696212e-06 miRNATAP -0.37895363990272 1.56889088387983e-07 NA NA NA hsa-miR-543 BMP2 -0.347737549779625 0.0157394585079683 -0.652254459003093 5.61382094696212e-06 PITA;miRanda;miRNATAP -0.322042093445909 4.45832410272365e-14 NA NA NA hsa-miR-590-3p BMP2 0.312951515438396 0.000480455423843996 -0.652254459003093 5.61382094696212e-06 PITA;miRanda;mirMAP -0.637696775870909 4.13711684786646e-22 NA NA NA hsa-miR-654-3p BMP2 -0.00355488592826836 0.97967144096285 -0.652254459003093 5.61382094696212e-06 PITA;miRNATAP -0.322678761779993 1.13204555148555e-13 NA NA NA hsa-miR-106b-5p BMP7 0.167096183547615 0.0497544396383451 -0.124446669279862 0.0994506941687388 mirMAP -0.196550369586811 1.61068912373631e-07 NA NA NA hsa-miR-17-5p BMP7 0.0975751369167082 0.20621110214601 -0.124446669279862 0.0994506941687388 mirMAP -0.226306052825787 6.18157462865439e-07 NA NA NA hsa-miR-1976 BMP7 0.127074435034705 0.277235601775457 -0.124446669279862 0.0994506941687388 MirTarget -0.126432438325058 1.28330757566489e-07 NA NA NA hsa-miR-22-3p BMP7 0.0277287593466351 0.809325106832648 -0.124446669279862 0.0994506941687388 miRNAWalker2_validate;miRTarBase -0.12783123485122 0.00018583018825058 NA NA NA hsa-miR-30b-5p BMP7 -0.0858101016322106 0.263243418521854 -0.124446669279862 0.0994506941687388 mirMAP -0.13314274732787 0.00290899760326754 NA NA NA hsa-miR-30c-5p BMP7 -0.0469114469943097 0.565934557464627 -0.124446669279862 0.0994506941687388 mirMAP;miRNATAP -0.228275842045227 2.95643469876389e-07 NA NA NA hsa-miR-30e-5p BMP7 0.0764521828640934 0.41904991629622 -0.124446669279862 0.0994506941687388 mirMAP -0.303468478594113 2.58399346376814e-13 NA NA NA hsa-miR-342-3p BMP7 -0.125683829770877 0.105810751640137 -0.124446669279862 0.0994506941687388 miRNAWalker2_validate;miRTarBase;miRanda -0.308628850233122 1.38977970302304e-14 NA NA NA hsa-miR-361-5p BMP7 0.0107519600643302 0.882230614095565 -0.124446669279862 0.0994506941687388 miRanda -0.132929860284828 0.00635845362883548 NA NA NA hsa-miR-455-5p BMP7 0.332224239762 0.0106491358056238 -0.124446669279862 0.0994506941687388 miRanda -0.164119247897386 1.45004894845219e-14 NA NA NA hsa-miR-93-5p BMP7 0.139766237971122 0.101057320076629 -0.124446669279862 0.0994506941687388 mirMAP -0.234850078062666 4.46958733793779e-06 NA NA NA hsa-let-7a-3p CTNNB1 0.0530563276543763 0.370749834463566 0.0357918808324289 0.517099644291201 MirTarget;miRNATAP -0.100275934552221 7.48576342515523e-05 NA NA NA hsa-miR-15a-5p EPB41L5 0.142658985373611 0.0536219185009004 -0.0201228127420752 0.709356053714152 MirTarget -0.102519227161406 0.00081770219097551 NA NA NA hsa-miR-361-5p EPB41L5 0.0107519600643302 0.882230614095565 -0.0201228127420752 0.709356053714152 mirMAP -0.130820585838808 4.2533598188981e-05 NA NA NA hsa-miR-139-5p FAM83D -0.647754756897633 2.15378307237163e-06 0.883078215432626 3.80882045810101e-12 miRanda -0.11533601208354 0.00715192328591516 NA NA NA hsa-miR-19b-1-5p FGFR2 0.0686579042235509 0.332645627997485 -0.492577222868217 7.16897440371588e-05 miRNAWalker2_validate;miRTarBase -0.219237513523795 0.00418312265430993 NA NA NA hsa-miR-767-3p FGFR2 -0.429854368420513 0.000821445291167688 -0.492577222868217 7.16897440371588e-05 miRNATAP -0.194318397286558 3.97094001404658e-06 NA NA NA hsa-miR-200b-3p FOXF2 0.245768526504511 0.0580744465744737 0.281552025373694 0.00148514900462949 TargetScan -0.151335459823145 4.97586373446374e-07 25798833 The miR 200 family and the miR 183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers; We therefore identified a novel mechanism whereby the miR-200 family and the miR-183~96~182 cluster inhibit lung cancer invasion and metastasis by targeting Foxf2 metastasis lung cancer hsa-miR-200c-3p FOXF2 0.413752622631695 8.6936333715621e-06 0.281552025373694 0.00148514900462949 miRNATAP -0.180214690286996 1.2064063707492e-05 NA NA NA hsa-miR-26b-5p FOXF2 -0.0984536538762768 0.231803769574623 0.281552025373694 0.00148514900462949 miRNAWalker2_validate -0.203959228576632 0.00027695150123531 NA NA NA hsa-miR-301a-3p FOXF2 0.00956875714542704 0.916380325220259 0.281552025373694 0.00148514900462949 miRNATAP -0.338595816227113 5.06141434121208e-15 NA NA NA hsa-miR-454-3p FOXF2 0.177318549827649 0.0120865170334418 0.281552025373694 0.00148514900462949 miRNATAP -0.173923097705111 0.00231000854733593 NA NA NA hsa-miR-590-3p FOXF2 0.312951515438396 0.000480455423843996 0.281552025373694 0.00148514900462949 PITA;miRanda -0.114147470874124 0.00806047516662228 NA NA NA hsa-miR-135a-5p GSK3B -0.122734612943241 0.196985964641886 -0.00812669327682514 0.891858643750953 miRNATAP -0.155009045241408 4.27981971726539e-12 NA NA NA hsa-miR-23a-3p GSK3B 0.334693010651106 0.00144448147063433 -0.00812669327682514 0.891858643750953 mirMAP;miRNATAP -0.109796590797861 1.08992592703854e-06 NA NA NA hsa-miR-26a-5p GSK3B 0.033823776747294 0.726610414342369 -0.00812669327682514 0.891858643750953 miRNAWalker2_validate;miRNATAP -0.124162553965791 1.9677050059957e-06 NA NA NA hsa-miR-26b-5p GSK3B -0.0984536538762768 0.231803769574623 -0.00812669327682514 0.891858643750953 miRNATAP -0.242462216035707 2.93659997949065e-16 NA NA NA hsa-miR-27a-3p GSK3B 0.303760032895792 0.00457375391189806 -0.00812669327682514 0.891858643750953 miRNATAP -0.117289047610676 2.03194827601435e-08 NA NA NA hsa-miR-28-5p GSK3B 0.104003572105781 0.153594705579534 -0.00812669327682514 0.891858643750953 miRanda;miRNATAP -0.153581288033644 5.93445649657903e-07 NA NA NA hsa-miR-29b-3p GSK3B -0.178522712044497 0.0856106432165465 -0.00812669327682514 0.891858643750953 miRTarBase;miRNATAP -0.103024519445492 4.4831296698937e-06 NA NA NA hsa-miR-30a-3p GSK3B 0.0655410309550977 0.509541256241954 -0.00812669327682514 0.891858643750953 miRNATAP -0.169749215445873 3.72672045563906e-10 NA NA NA hsa-miR-320a GSK3B 0.092135599636725 0.243028758989929 -0.00812669327682514 0.891858643750953 miRanda;mirMAP -0.157366520986088 1.86207365140069e-06 NA NA NA hsa-miR-320c GSK3B 0.343259124189966 0.000248338401291051 -0.00812669327682514 0.891858643750953 miRanda;mirMAP -0.105871202268296 3.45649295394405e-06 NA NA NA hsa-miR-362-5p GSK3B -0.0730185557229279 0.425572997292224 -0.00812669327682514 0.891858643750953 miRNATAP -0.14675268746991 1.54588705430119e-10 NA NA NA hsa-miR-374b-5p GSK3B -0.210113949579608 0.0056866083818614 -0.00812669327682514 0.891858643750953 mirMAP -0.110240926558385 0.000413708905199806 NA NA NA hsa-miR-590-3p GSK3B 0.312951515438396 0.000480455423843996 -0.00812669327682514 0.891858643750953 miRanda;miRNATAP -0.123129209082978 1.01101816997511e-07 NA NA NA hsa-miR-664a-3p GSK3B 0.0413918462467198 0.611334357897022 -0.00812669327682514 0.891858643750953 mirMAP -0.156185915215911 2.17302109400583e-09 NA NA NA hsa-miR-708-5p GSK3B -0.00936519718301376 0.919857671524527 -0.00812669327682514 0.891858643750953 miRNATAP -0.121813780965153 5.84337104157163e-07 NA NA NA hsa-miR-99a-3p GSK3B -0.122217114840767 0.0886582098510828 -0.00812669327682514 0.891858643750953 miRNATAP -0.17367661337822 1.70824739875318e-08 NA NA NA hsa-miR-106a-5p HIF1A 0.110074064773897 0.13045815990621 -0.00484625688143137 0.948287190529417 MirTarget -0.101846451398848 0.00786647918909839 NA NA NA hsa-miR-107 HIF1A -0.121070851008387 0.198381281894242 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;miRTarBase;miRanda -0.132322237829831 7.00061612742853e-06 NA NA NA hsa-miR-138-5p HIF1A -0.616087649920851 1.35200027885729e-05 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;miRTarBase -0.165502020945438 2.83284283527236e-20 21875287 Western blot and reporter assays were used to assess HIF-1a as a direct target of miR-138; The data showed HIF-1a to be one target of miR-138; Futhermore inhibition of the expression of HIF-1a with specific siRNA or miR-138 could increase apoptosis and reduce the migration of 786-O cells; miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of ccRCC cells kidney renal cell cancer hsa-miR-139-5p HIF1A -0.647754756897633 2.15378307237163e-06 -0.00484625688143137 0.948287190529417 miRanda -0.15297457161476 2.12780776743694e-15 NA NA NA hsa-miR-18a-5p HIF1A 0.175320895022849 0.0732549187136286 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;MirTarget -0.129916223031346 1.01926663208999e-06 25069832 Last clinically relevant correlations between miR-18a HIF1A hypoxia-responsive gene expression and distant metastasis-free survival DMFS were assessed using published expression array breast tumors data sets; We identified HIF1A as a direct target of miR-18a; Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxic genes is associated with shorter DMFS interval in patients with basal-like breast tumors and that within this subtype miR-18a expression is inversely correlated with hypoxic gene expression; The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors metastasis;poor survival breast cancer hsa-miR-20a-5p HIF1A -0.0115865752288853 0.887069448776018 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate;miRTarBase;MirTarget -0.112673000912119 0.00365252545629883 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-330-3p HIF1A -0.427388106938151 0.00300489284414266 -0.00484625688143137 0.948287190529417 MirTarget;PITA -0.116720940808285 6.02712620528516e-11 NA NA NA hsa-miR-338-3p HIF1A -0.39963704679384 0.0034410643220691 -0.00484625688143137 0.948287190529417 MirTarget;PITA;miRanda -0.168505832987204 2.19429877940535e-16 NA NA NA hsa-miR-338-5p HIF1A -0.424003687569629 0.00246415720301323 -0.00484625688143137 0.948287190529417 MirTarget;PITA;miRNATAP -0.11983832401039 1.29865674406497e-10 NA NA NA hsa-miR-33a-5p HIF1A 0.0197996465877179 0.86830656038963 -0.00484625688143137 0.948287190529417 miRNAWalker2_validate -0.102950741341759 2.74195519214452e-06 NA NA NA hsa-miR-346 HIF1A -0.577786425963268 2.10883270131593e-09 -0.00484625688143137 0.948287190529417 miRanda -0.147315192018374 3.61376868607022e-08 NA NA NA hsa-miR-361-5p HIF1A 0.0107519600643302 0.882230614095565 -0.00484625688143137 0.948287190529417 miRanda -0.258505450799868 6.22305933429022e-09 NA NA NA hsa-miR-433-3p HIF1A -0.584416505057956 0.00091765848343232 -0.00484625688143137 0.948287190529417 MirTarget -0.112298468414992 7.58027288480129e-15 NA NA NA hsa-miR-543 HIF1A -0.347737549779625 0.0157394585079683 -0.00484625688143137 0.948287190529417 miRanda -0.106805373479425 6.61274439561097e-09 NA NA NA hsa-miR-582-3p HIF1A -0.11807589183011 0.304077332003677 -0.00484625688143137 0.948287190529417 PITA -0.15709347676521 8.94306398856027e-12 NA NA NA hsa-miR-582-5p HIF1A -0.215764335500665 0.0760892640434509 -0.00484625688143137 0.948287190529417 MirTarget;PITA;miRNATAP -0.149685053695624 1.07373090822328e-12 NA NA NA hsa-miR-889-3p HIF1A -0.380772047661407 0.0172235256323877 -0.00484625688143137 0.948287190529417 MirTarget -0.104858814783013 9.61920147963016e-11 NA NA NA hsa-miR-935 HIF1A -0.277848050075718 0.02166231531395 -0.00484625688143137 0.948287190529417 MirTarget;PITA -0.15182237312319 2.87889204454712e-12 NA NA NA hsa-miR-105-5p HMGA2 -0.567459149851677 8.20858944634795e-06 1.1550067152221 1.29553089142071e-07 mirMAP -0.458507158754035 1.51075771102395e-09 NA NA NA hsa-miR-129-5p HMGA2 -0.567133990117126 0.00116152215679936 1.1550067152221 1.29553089142071e-07 miRanda;mirMAP -0.180121468672167 0.00134622763130282 NA NA NA hsa-miR-137 HMGA2 -0.924849266740909 1.546832202049e-06 1.1550067152221 1.29553089142071e-07 MirTarget;PITA;miRanda -0.148476087760722 0.00259957018169401 NA NA NA hsa-miR-195-5p HMGA2 -0.00728332132631593 0.92969850577609 1.1550067152221 1.29553089142071e-07 MirTarget -0.378547719088979 0.00274607172696458 NA NA NA hsa-miR-326 HMGA2 -0.631050656251074 8.83643450601471e-05 1.1550067152221 1.29553089142071e-07 miRNATAP -0.155897475654289 0.00850235037482843 NA NA NA hsa-miR-346 HMGA2 -0.577786425963268 2.10883270131593e-09 1.1550067152221 1.29553089142071e-07 miRanda -0.423310803094727 1.72798166807328e-05 NA NA NA hsa-miR-490-3p HMGA2 -0.834268051506884 5.26203010743215e-06 1.1550067152221 1.29553089142071e-07 PITA;miRanda;miRNATAP -0.147513073166237 0.00529364801449807 26341146 MicroRNA 490 3p regulates cell proliferation and apoptosis by targeting HMGA2 in osteosarcoma; Furthermore miR-490-3p bound directly to HMGA2 mRNA 3'UTR and mediated a decrease in HMGA2 mRNA and protein expression; Re-expression of HMGA2 reversed the inhibitory effects of miR-490-3p; Further investigations showed an inverse correlation between low miR-490-3p and high HMGA2 expression in osteosarcoma tissues; Taken together our results suggest that miR-490-3p functions as a potential tumor suppressor by down-regulating HMGA2 expression directly and it may represent a potential therapeutic target for patients with osteosarcoma sarcoma hsa-miR-491-5p HMGA2 -0.749881113074983 8.22859263179194e-09 1.1550067152221 1.29553089142071e-07 PITA;miRanda -0.281389732425662 9.80710869202949e-05 NA NA NA hsa-miR-497-5p HMGA2 -0.000783764887886562 0.991703566618871 1.1550067152221 1.29553089142071e-07 MirTarget -0.558921016294887 4.44020957114579e-05 NA NA NA hsa-miR-9-3p HMGA2 -0.184945845984695 0.0290051908009009 1.1550067152221 1.29553089142071e-07 mirMAP -0.680677985625124 9.69182123394948e-06 NA NA NA hsa-miR-9-5p HMGA2 -0.125377971246422 0.269896477802284 1.1550067152221 1.29553089142071e-07 miRNATAP -1.8520181615207 1.13175904586965e-19 NA NA NA hsa-miR-139-5p HNRNPAB -0.647754756897633 2.15378307237163e-06 0.19057991736564 0.000556612440179237 miRanda -0.139926088777705 3.50686738814379e-27 NA NA NA hsa-miR-29b-2-5p HNRNPAB -0.26834261955727 0.00453760540520233 0.19057991736564 0.000556612440179237 MirTarget -0.200300679488665 4.17646377050338e-27 NA NA NA hsa-miR-504-5p HNRNPAB -0.510726779625117 6.12122269907368e-05 0.19057991736564 0.000556612440179237 miRNAWalker2_validate -0.105372833201391 6.19948787722348e-14 NA NA NA hsa-miR-3065-3p LEF1 -0.261348288537884 0.0343753235107924 0.349249191099076 1.77383475142338e-06 miRNATAP -0.100710465302502 0.000109595604303436 NA NA NA hsa-miR-153-3p LIMS1 -0.173449510253619 0.0654368045743418 0.197815718091878 0.0202387619873331 MirTarget -0.142848748533607 0.000359672533065564 NA NA NA hsa-miR-29b-3p LIMS1 -0.178522712044497 0.0856106432165465 0.197815718091878 0.0202387619873331 MirTarget;miRNATAP -0.161477800718387 3.37531297287543e-05 NA NA NA hsa-miR-30b-5p LIMS1 -0.0858101016322106 0.263243418521854 0.197815718091878 0.0202387619873331 MirTarget -0.285939571375665 4.33187024204515e-07 NA NA NA hsa-miR-30c-5p LIMS1 -0.0469114469943097 0.565934557464627 0.197815718091878 0.0202387619873331 MirTarget -0.164118168605899 0.00416563418395766 NA NA NA hsa-miR-7-1-3p LIMS1 -0.0894475316162393 0.37322359785108 0.197815718091878 0.0202387619873331 mirMAP -0.107322845098497 0.00316676592531034 NA NA NA hsa-miR-9-3p LIMS1 -0.184945845984695 0.0290051908009009 0.197815718091878 0.0202387619873331 mirMAP -0.249477028109974 1.67476061005759e-05 NA NA NA hsa-miR-338-3p LOXL2 -0.39963704679384 0.0034410643220691 0.844032182250698 7.51211358348014e-13 miRanda -0.243197393191499 3.950304698454e-09 NA NA NA hsa-miR-127-5p LOXL3 -0.128719168376827 0.401210814502785 0.456045225022194 8.56229776763479e-08 PITA -0.101848549296817 3.02442793902415e-05 NA NA NA hsa-miR-137 LOXL3 -0.924849266740909 1.546832202049e-06 0.456045225022194 8.56229776763479e-08 MirTarget -0.117430094413254 1.78095836155879e-10 NA NA NA hsa-miR-628-5p LOXL3 -0.0469793532265896 0.657420003383685 0.456045225022194 8.56229776763479e-08 MirTarget;miRNATAP -0.131704225961118 0.000175134092409938 NA NA NA hsa-miR-101-3p NOG -0.132333931567244 0.241891922291381 -0.760561805509224 2.90870221056909e-08 miRNATAP -0.228678379709781 0.000915656930377825 NA NA NA hsa-miR-126-5p NOG 0.177332403948664 0.0711675116243123 -0.760561805509224 2.90870221056909e-08 mirMAP;miRNATAP -0.324665401786113 3.24212968617282e-07 NA NA NA hsa-miR-142-5p NOG 0.434884875454107 0.000575570345702788 -0.760561805509224 2.90870221056909e-08 miRNATAP -0.560783396644936 3.21832687885349e-37 NA NA NA hsa-miR-144-3p NOG 0.185426471537742 0.329598425352088 -0.760561805509224 2.90870221056909e-08 miRNATAP -0.175754769025154 2.50858583082881e-08 NA NA NA hsa-miR-148a-3p NOG 0.306821592493439 0.0392356958885949 -0.760561805509224 2.90870221056909e-08 MirTarget;miRNATAP -0.554328291021439 4.41295324694495e-46 NA NA NA hsa-miR-148b-3p NOG 0.0710353380371513 0.322794068460232 -0.760561805509224 2.90870221056909e-08 MirTarget -0.868128147758898 1.09941290380725e-20 NA NA NA hsa-miR-152-3p NOG -0.170744204297152 0.118543672664884 -0.760561805509224 2.90870221056909e-08 MirTarget -0.294428051095496 3.83327673767612e-07 NA NA NA hsa-miR-186-5p NOG 0.0606381894130505 0.514217717592464 -0.760561805509224 2.90870221056909e-08 MirTarget;miRNATAP -0.859558688991068 1.5847633812957e-38 NA NA NA hsa-miR-193a-3p NOG 0.395602305834739 0.00182611787714301 -0.760561805509224 2.90870221056909e-08 miRanda -0.56132117322483 1.56977418141598e-35 NA NA NA hsa-miR-200b-3p NOG 0.245768526504511 0.0580744465744737 -0.760561805509224 2.90870221056909e-08 MirTarget;TargetScan -0.535826107671944 1.01935825858448e-33 NA NA NA hsa-miR-200c-3p NOG 0.413752622631695 8.6936333715621e-06 -0.760561805509224 2.90870221056909e-08 MirTarget;miRNATAP -0.732044213044626 7.70002113294763e-34 NA NA NA hsa-miR-26b-3p NOG -0.0542537787460029 0.4802214385739 -0.760561805509224 2.90870221056909e-08 MirTarget -0.471969061431571 3.8527016167321e-09 NA NA NA hsa-miR-296-5p NOG -0.0192165981442809 0.870822664524408 -0.760561805509224 2.90870221056909e-08 miRNATAP -0.2749827386907 5.10103709417989e-08 NA NA NA hsa-miR-340-5p NOG -0.110504550202736 0.20522426193476 -0.760561805509224 2.90870221056909e-08 MirTarget -0.265197727168221 0.000298441102329301 NA NA NA hsa-miR-362-3p NOG 0.032375035235532 0.736465332563774 -0.760561805509224 2.90870221056909e-08 miRanda;miRNATAP -0.296339101297785 1.89928932431526e-06 NA NA NA hsa-miR-369-3p NOG -0.153496605399658 0.296055925448078 -0.760561805509224 2.90870221056909e-08 PITA;miRNATAP -0.28720787737892 8.94409909840397e-13 NA NA NA hsa-miR-375 NOG -0.0268401141324031 0.858358101444697 -0.760561805509224 2.90870221056909e-08 miRanda -0.16871750008596 2.00423650931477e-05 NA NA NA hsa-miR-543 NOG -0.347737549779625 0.0157394585079683 -0.760561805509224 2.90870221056909e-08 miRanda -0.272269320861412 8.37292040632233e-11 NA NA NA hsa-miR-582-3p NOG -0.11807589183011 0.304077332003677 -0.760561805509224 2.90870221056909e-08 PITA;miRNATAP -0.146123972779829 0.00643281272329909 NA NA NA hsa-miR-101-3p NOTCH1 -0.132333931567244 0.241891922291381 -0.021675781444384 0.784456320866891 MirTarget -0.187416719240291 1.0940497082962e-08 NA NA NA hsa-miR-139-5p NOTCH1 -0.647754756897633 2.15378307237163e-06 -0.021675781444384 0.784456320866891 PITA;miRanda;miRNATAP -0.126275438431501 3.97588150952362e-09 27173050;25149074;26299922;27738333;24885920 miR 139 5p sensitizes colorectal cancer cells to 5 fluorouracil by targeting NOTCH 1;MiR 139 5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1; Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1;MiR 139 5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel; MiR-139-5p expression in MCF-7 MCF-7/Doc cells and in selected breast cancer tissue samples was confirmed by real-time PCR; cell viability was analyzed by Cell Counting Kit-8 assay; apoptosis and cell cycle were analyzed by flow cytometry; control of metastasis and invasion of breast cancer cells was measured by transwell assay; expression of Notch1 was measured by western blot; a luciferase reporter vector was constructed to identify the miR-139-5p target gene; MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1;MiR 139 5p reverses CD44+/CD133+ associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells; We also identified NOTCH1 an important protein for stem cell maintenance and function as a direct target of miR-139-5p both in vitro and in a knockout mouse model; Notch1 expression was upregulated in tumor samples and inversely correlated with expression of miR-139-5p; Silencing NOTCH1 exerted an effect similar to overexpression of miR-139-5p by inhibiting the CD44+ and CD133+ population and reversing the drug-resistant phenotype; In conclusion miR-139-5p downregulated NOTCH1 signaling to reverse CD44+/CD133+-associated MDR in colorectal cancer cells;microRNA 139 5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer ;metastasis;metastasis;drug resistance;drug resistance; colorectal cancer;colorectal cancer;breast cancer;colorectal cancer;colorectal cancer hsa-miR-199a-5p NOTCH1 0.174889610847968 0.0900027418912454 -0.021675781444384 0.784456320866891 miRanda -0.223141716427289 6.43002034730432e-16 NA NA NA hsa-miR-199b-5p NOTCH1 0.436298593972862 0.00200225454383871 -0.021675781444384 0.784456320866891 miRanda -0.148099403035626 9.02018277805841e-14 24659709 Epigenetic silencing of microRNA 199b 5p is associated with acquired chemoresistance via activation of JAG1 Notch1 signaling in ovarian cancer; Here we report that the loss of miR-199b-5p due to progressive epigenetic silencing leads to the activation of the JAG1-mediated Notch1 signaling cascade thereby leading to the development of acquired chemoresistance in ovarian cancer drug resistance;progression ovarian cancer hsa-miR-200b-3p NOTCH1 0.245768526504511 0.0580744465744737 -0.021675781444384 0.784456320866891 MirTarget;TargetScan -0.208194895947003 1.36204710092618e-21 26012256;23430952 Nobiletin inhibited hypoxia induced epithelial mesenchymal transition of lung cancer cells by inactivating of Notch 1 signaling and switching on miR 200b; Our findings suggest that downregulation of Notch-1 and reexpression of miR-200b by nobiletin might be a novel remedy for the therapy of lung cancer;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis ; lung cancer;sarcoma hsa-miR-200c-3p NOTCH1 0.413752622631695 8.6936333715621e-06 -0.021675781444384 0.784456320866891 MirTarget -0.223317170493912 1.59468039606813e-13 NA NA NA hsa-miR-2355-5p NOTCH1 0.00808596988211185 0.916165501155096 -0.021675781444384 0.784456320866891 MirTarget -0.379997968696284 1.17598104591566e-23 NA NA NA hsa-miR-23b-3p NOTCH1 0.0476610245860094 0.630277683372344 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase -0.315065111358011 7.25440212558849e-24 NA NA NA hsa-miR-24-3p NOTCH1 0.133257261462871 0.212960921400853 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase -0.25201904466456 4.00584083162083e-18 NA NA NA hsa-miR-27b-3p NOTCH1 -0.0599187745243146 0.58208143475992 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase -0.268442320679108 1.80808420510082e-21 NA NA NA hsa-miR-28-5p NOTCH1 0.104003572105781 0.153594705579534 -0.021675781444384 0.784456320866891 miRanda -0.35339179425784 1.51695440792741e-17 NA NA NA hsa-miR-30a-5p NOTCH1 -0.062942936611238 0.513851954700252 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase;miRNATAP -0.42323267898728 1.02834042721951e-18 NA NA NA hsa-miR-30b-5p NOTCH1 -0.0858101016322106 0.263243418521854 -0.021675781444384 0.784456320866891 miRNATAP -0.27287127782669 1.12822373944111e-09 NA NA NA hsa-miR-30c-5p NOTCH1 -0.0469114469943097 0.565934557464627 -0.021675781444384 0.784456320866891 miRNATAP -0.376813230277597 1.64124274123235e-17 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations differentiation acute myeloid leukemia hsa-miR-30d-5p NOTCH1 -0.0607010868720046 0.471410043548794 -0.021675781444384 0.784456320866891 miRNATAP -0.363186371240126 1.0261492743008e-12 NA NA NA hsa-miR-32-5p NOTCH1 0.130313603388223 0.177843055266148 -0.021675781444384 0.784456320866891 miRNATAP -0.154149569248209 3.2042444497718e-07 NA NA NA hsa-miR-34a-5p NOTCH1 0.143472919835524 0.211283228567057 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.282796793876507 2.68894872856004e-31 21743299;22438124;23140286;24349627;24565525;25783790;20351093;27082152;23642368;22347519;23430952;23902763;22992310;23145211;25623761;23085450 MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1 ;;;;cell migration;staging;metastasis;drug resistance;;differentiation;drug resistance;;;;;;;drug resistance glioblastoma;lung squamous cell cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;cervical and endocervical cancer;breast cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;colon cancer;prostate cancer;breast cancer;breast cancer hsa-miR-34c-5p NOTCH1 0.181931113688093 0.257266965617363 -0.021675781444384 0.784456320866891 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.107537464613802 8.92317727559482e-10 24802328 Taken together our data indicate that miR-34c suppresses OS metastasis and chemoresistance by targeting Notch1 and LEF1 metastasis;drug resistance sarcoma hsa-miR-369-3p NOTCH1 -0.153496605399658 0.296055925448078 -0.021675781444384 0.784456320866891 PITA -0.157623336163144 1.88500406617029e-16 NA NA NA hsa-miR-582-5p NOTCH1 -0.215764335500665 0.0760892640434509 -0.021675781444384 0.784456320866891 PITA;miRNATAP -0.122147705388324 1.65996696375078e-07 NA NA NA hsa-let-7e-5p RBPJ 0.0471189209570344 0.657255455444655 0.00383693564086229 0.953144771006534 miRNATAP -0.127731305944253 2.1380353960429e-06 NA NA NA hsa-miR-132-3p RBPJ -0.178379362833856 0.13335200877129 0.00383693564086229 0.953144771006534 mirMAP -0.120649442556272 2.15847861295186e-08 NA NA NA hsa-miR-155-5p RBPJ 0.969837380981085 5.86551495710056e-15 0.00383693564086229 0.953144771006534 miRNAWalker2_validate -0.127852993406769 1.12206123408632e-11 NA NA NA hsa-miR-200b-3p RBPJ 0.245768526504511 0.0580744465744737 0.00383693564086229 0.953144771006534 mirMAP -0.124078499079245 5.1195361414368e-11 NA NA NA hsa-miR-200c-3p RBPJ 0.413752622631695 8.6936333715621e-06 0.00383693564086229 0.953144771006534 mirMAP -0.103079825781586 7.86991513553507e-05 NA NA NA hsa-miR-22-5p RBPJ 0.0437233965539527 0.639996108995995 0.00383693564086229 0.953144771006534 MirTarget;miRNATAP -0.201033751803788 8.58249817231906e-15 NA NA NA hsa-miR-361-5p RBPJ 0.0107519600643302 0.882230614095565 0.00383693564086229 0.953144771006534 miRanda -0.120283834254296 0.00407684069176925 NA NA NA hsa-miR-543 RBPJ -0.347737549779625 0.0157394585079683 0.00383693564086229 0.953144771006534 miRanda;mirMAP;miRNATAP -0.103649888259231 1.34897232166163e-09 NA NA NA hsa-miR-664a-3p RBPJ 0.0413918462467198 0.611334357897022 0.00383693564086229 0.953144771006534 mirMAP -0.232772661445295 1.10350854879674e-14 NA NA NA hsa-miR-7-1-3p RBPJ -0.0894475316162393 0.37322359785108 0.00383693564086229 0.953144771006534 mirMAP -0.132140476428887 5.28193702118985e-08 NA NA NA hsa-miR-3622a-3p SNAI2 0.0389203848593471 0.75605812962459 0.420616853894134 0.000182314677489613 MirTarget;miRNATAP -0.115397915117584 0.00417891997901791 NA NA NA hsa-miR-9-5p SNAI2 -0.125377971246422 0.269896477802284 0.420616853894134 0.000182314677489613 miRNAWalker2_validate -0.515710271997973 1.71483886465132e-06 NA NA NA hsa-let-7a-3p SOX9 0.0530563276543763 0.370749834463566 0.109990593387177 0.196749110524472 MirTarget;miRNATAP -0.228127672225122 0.000165938268000543 NA NA NA hsa-let-7b-3p SOX9 -0.00495618733298731 0.952288980686967 0.109990593387177 0.196749110524472 MirTarget;miRNATAP -0.176756480099569 1.16259181048343e-05 NA NA NA hsa-miR-1-3p SOX9 -0.218035884810576 0.125196862509753 0.109990593387177 0.196749110524472 MirTarget -0.144892910255258 5.01038362715928e-11 NA NA NA hsa-miR-124-3p SOX9 -0.506026514549291 0.0078056370358648 0.109990593387177 0.196749110524472 miRNATAP -0.100965688807184 1.51964307717467e-09 26935152 MiR 124 inhibits cell proliferation migration and invasion by directly targeting SOX9 in lung adenocarcinoma; In the present study we detected miR-124 and SOX9 expression in lung ADC tissues; The results showed that miR-124 was significantly downregulated in the lung ADC tissues compared with that noted in the corresponding non-cancerous lung tissues and the level of SOX9 protein was inversely associated with the expression of miR-124; The bioinformatic analysis showed that there was a putative miR-124 binding site in the 3' untranslated region 3'UTR of SOX9; Using a luciferase reporter assay we verified that SOX9 is a direct target of miR-124; Furthermore overexpression of miR-124 repressed SOX9 expression whereas inhibition of miR-124 increased expression of SOX9 in the A549 cells; Finally we identified that SOX9 was a functional mediator of miR-124 in A549 cells lung cancer hsa-miR-145-5p SOX9 0.108948399943015 0.310032352776693 0.109990593387177 0.196749110524472 miRNATAP -0.156330584768586 6.61908707232107e-07 25145279;24631504 The epigenetic regulation of SOX9 by miR 145 in human chondrosarcoma; We hypothesized that the expression of miR-145 is low in chondrosarcoma leading to decreased transcriptional control of SOX9 the master regulator of chondrogenesis and downstream activation of the transcription factor ETV5;Ectopic expression of miR-145 in turn regulates SOX9 expression through the binding to specific seed motifs; Together these results suggest that miR-145 is a novel target of PPARγ acts as a tumor suppressor in CRC cell lines and is a key regulator of intestinal cell differentiation by directly targeting SOX9 a marker of undifferentiated progenitors in the colonic crypts ;differentiation sarcoma;colorectal cancer hsa-miR-199a-5p SOX9 0.174889610847968 0.0900027418912454 0.109990593387177 0.196749110524472 miRNAWalker2_validate -0.100613890013229 0.00142248260466328 NA NA NA hsa-miR-30b-5p SOX9 -0.0858101016322106 0.263243418521854 0.109990593387177 0.196749110524472 MirTarget -0.188536596893978 0.000184033185788519 NA NA NA hsa-miR-33a-3p SOX9 -0.158366376619191 0.0991512910387226 0.109990593387177 0.196749110524472 mirMAP -0.108673398000901 0.00121396431603768 NA NA NA hsa-miR-582-3p SOX9 -0.11807589183011 0.304077332003677 0.109990593387177 0.196749110524472 PITA;miRNATAP -0.142304459227833 5.54450644492637e-07 NA NA NA hsa-miR-582-5p SOX9 -0.215764335500665 0.0760892640434509 0.109990593387177 0.196749110524472 PITA;miRNATAP -0.131283000252942 4.41135792498476e-07 NA NA NA hsa-miR-139-5p TGFB1 -0.647754756897633 2.15378307237163e-06 0.188661409906809 0.0283645098828165 miRanda -0.257914873895623 5.01185822136258e-24 NA NA NA hsa-let-7a-3p TGFB2 0.0530563276543763 0.370749834463566 0.770124480266937 2.43471584041631e-07 miRNATAP -0.442723562700544 0.000358820362673608 NA NA NA hsa-miR-181a-2-3p TGFB2 -0.0630409614874416 0.473088318215936 0.770124480266937 2.43471584041631e-07 MirTarget -0.480565043297097 4.63300164322775e-06 NA NA NA hsa-miR-9-3p TGFB2 -0.184945845984695 0.0290051908009009 0.770124480266937 2.43471584041631e-07 MirTarget -0.502297808087689 1.67671098075053e-06 NA NA NA hsa-let-7d-5p TGFBR1 0.111345229817909 0.0872634398336815 0.339248208669654 4.04767020934912e-07 miRNAWalker2_validate;miRNATAP -0.154436649206706 0.00201422979804352 NA NA NA hsa-let-7g-5p TGFBR1 -0.0253396334608382 0.742556489443668 0.339248208669654 4.04767020934912e-07 miRNATAP -0.119325470730491 0.00744772702777702 NA NA NA hsa-miR-101-5p TGFBR1 -0.263105484860745 0.00306900408113868 0.339248208669654 4.04767020934912e-07 mirMAP -0.170663135357559 1.09969750824995e-08 NA NA NA hsa-miR-124-3p TGFBR1 -0.506026514549291 0.0078056370358648 0.339248208669654 4.04767020934912e-07 miRNATAP -0.111716058691644 9.37933645710229e-17 NA NA NA hsa-miR-128-3p TGFBR1 -0.781932174412672 7.1812756321342e-10 0.339248208669654 4.04767020934912e-07 miRNAWalker2_validate;miRTarBase -0.210164447590872 1.78152956429912e-22 NA NA NA hsa-miR-3200-3p TGFBR1 -0.485743434053711 2.90556089083004e-06 0.339248208669654 4.04767020934912e-07 miRNATAP -0.163923881348339 1.17145766418329e-10 NA NA NA hsa-miR-490-3p TGFBR1 -0.834268051506884 5.26203010743215e-06 0.339248208669654 4.04767020934912e-07 PITA;miRanda;miRNATAP -0.116809003131924 7.17389189955076e-17 NA NA NA hsa-miR-7-1-3p TGFBR1 -0.0894475316162393 0.37322359785108 0.339248208669654 4.04767020934912e-07 mirMAP -0.193412951927122 5.6104947426979e-14 NA NA NA hsa-miR-769-5p TGFBR1 -0.320572895263071 0.00425481410304398 0.339248208669654 4.04767020934912e-07 PITA;miRNATAP -0.142395371930849 1.58733943690247e-09 NA NA NA hsa-miR-885-5p TGFBR1 -0.423614695846868 1.14213289528402e-05 0.339248208669654 4.04767020934912e-07 miRNATAP -0.210309423588542 8.19387972024476e-15 NA NA NA hsa-miR-935 TGFBR1 -0.277848050075718 0.02166231531395 0.339248208669654 4.04767020934912e-07 mirMAP -0.181329459956271 3.00813498843219e-17 NA NA NA hsa-let-7d-5p TGFBR3 0.111345229817909 0.0872634398336815 -0.300599922020896 0.000663908632465181 MirTarget -0.207114130352629 0.00332925443546992 NA NA NA hsa-miR-15b-5p TGFBR3 0.592863156692837 1.41971517354055e-10 -0.300599922020896 0.000663908632465181 MirTarget;miRNATAP -0.197782413700188 2.15739104521996e-06 NA NA NA hsa-miR-181b-5p TGFBR3 0.0260899284211646 0.768941836912518 -0.300599922020896 0.000663908632465181 mirMAP -0.252922004935925 1.02120722775238e-06 NA NA NA hsa-miR-18a-5p TGFBR3 0.175320895022849 0.0732549187136286 -0.300599922020896 0.000663908632465181 MirTarget -0.119606923481921 0.00149017696730178 NA NA NA hsa-miR-335-3p TGFBR3 0.34540584335595 0.00043848660222294 -0.300599922020896 0.000663908632465181 mirMAP -0.189389209482409 9.93553522691547e-07 NA NA NA hsa-miR-423-5p TGFBR3 0.0965587900813789 0.148039180704338 -0.300599922020896 0.000663908632465181 MirTarget -0.222486392122688 0.000362318898251134 NA NA NA hsa-miR-424-5p TGFBR3 0.25140374049676 0.00709934939774983 -0.300599922020896 0.000663908632465181 MirTarget;miRNATAP -0.158007631536378 0.000132407643254955 NA NA NA hsa-miR-450b-5p TGFBR3 0.270544879013992 0.00801537838499562 -0.300599922020896 0.000663908632465181 mirMAP -0.263251533831174 2.74896878741272e-13 NA NA NA hsa-miR-582-5p TGFBR3 -0.215764335500665 0.0760892640434509 -0.300599922020896 0.000663908632465181 mirMAP -0.151091507774452 4.49479065475997e-07 NA NA NA hsa-miR-193b-3p TRIM28 0.0766333116224072 0.324723824453143 0.152041427313453 0.0158160949848467 miRNAWalker2_validate -0.100917193532642 0.000135766793538099 NA NA NA hsa-miR-30a-5p TRIM28 -0.062942936611238 0.513851954700252 0.152041427313453 0.0158160949848467 miRNAWalker2_validate -0.12454292490278 0.000202253098008856 NA NA NA hsa-miR-582-3p TRIM28 -0.11807589183011 0.304077332003677 0.152041427313453 0.0158160949848467 MirTarget -0.116180290440619 1.29135622453097e-11 NA NA NA hsa-miR-126-5p WNT5A 0.177332403948664 0.0711675116243123 0.401727178109578 0.000135878679478885 mirMAP -0.197498035605205 2.92702569263705e-05 NA NA NA hsa-miR-127-5p WNT5A -0.128719168376827 0.401210814502785 0.401727178109578 0.000135878679478885 PITA;miRNATAP -0.148503710600712 5.58056138975753e-07 NA NA NA hsa-miR-129-5p WNT5A -0.567133990117126 0.00116152215679936 0.401727178109578 0.000135878679478885 PITA;miRanda;miRNATAP -0.122949419919608 1.9178703847978e-06 NA NA NA hsa-miR-140-3p WNT5A -0.123864258867705 0.14796686619449 0.401727178109578 0.000135878679478885 MirTarget;miRNATAP -0.304640564073949 8.7015213884132e-06 NA NA NA hsa-miR-154-5p WNT5A -0.226468848904462 0.107380908211261 0.401727178109578 0.000135878679478885 mirMAP;miRNATAP -0.133746849078689 2.20811690518715e-05 NA NA NA hsa-miR-182-5p WNT5A -0.146726537592027 0.389265298808118 0.401727178109578 0.000135878679478885 MirTarget -0.17706315884905 4.76584976388537e-11 NA NA NA hsa-miR-326 WNT5A -0.631050656251074 8.83643450601471e-05 0.401727178109578 0.000135878679478885 miRanda -0.121863379344651 7.54927535246161e-06 NA NA NA hsa-miR-330-5p WNT5A -0.262932095995605 0.0465226565966658 0.401727178109578 0.000135878679478885 miRanda -0.182269668340434 4.68881013813934e-08 NA NA NA hsa-miR-3607-3p WNT5A -0.0118040987013632 0.907228689257085 0.401727178109578 0.000135878679478885 mirMAP -0.158859120300375 0.00033593635970035 NA NA NA hsa-miR-369-3p WNT5A -0.153496605399658 0.296055925448078 0.401727178109578 0.000135878679478885 miRNATAP -0.109058905963049 0.000320216606169546 NA NA NA hsa-miR-409-3p WNT5A 0.00456692516634361 0.974143243758506 0.401727178109578 0.000135878679478885 mirMAP -0.110008292104967 0.000487794597719254 NA NA NA hsa-miR-491-3p WNT5A -0.523374665885358 1.93479565404951e-05 0.401727178109578 0.000135878679478885 mirMAP -0.148527988707063 3.61608334059833e-05 NA NA NA hsa-miR-539-5p WNT5A -0.326485413953598 0.0554453076411246 0.401727178109578 0.000135878679478885 mirMAP -0.161017969407705 3.21999166239326e-10 NA NA NA hsa-miR-582-5p WNT5A -0.215764335500665 0.0760892640434509 0.401727178109578 0.000135878679478885 miRNATAP -0.328837370224082 5.30150255364318e-21 NA NA NA hsa-miR-7-1-3p WNT5A -0.0894475316162393 0.37322359785108 0.401727178109578 0.000135878679478885 mirMAP -0.23358023082722 1.29867246418668e-07 NA NA NA hsa-miR-767-5p WNT5A -0.551653504513145 2.61109058244854e-05 0.401727178109578 0.000135878679478885 PITA;miRNATAP -0.21156019312404 4.27965570737888e-10 NA NA NA hsa-miR-885-5p WNT5A -0.423614695846868 1.14213289528402e-05 0.401727178109578 0.000135878679478885 MirTarget;PITA -0.286582466253295 6.75804778438008e-10 NA NA NA