miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p AIFM1 0.0582902155815681 0.781400138984745 -0.329550499905558 0.0674559184109906 miRNATAP -0.191354974755116 0.00202142122613475 NA NA NA hsa-let-7i-5p AIFM1 0.798954594465461 2.99735653959449e-05 -0.329550499905558 0.0674559184109906 miRNATAP -0.232193884359356 0.000490983449999865 NA NA NA hsa-miR-125a-5p AIFM1 -0.878090699011564 0.000213630844319685 -0.329550499905558 0.0674559184109906 miRanda -0.119312618723447 0.0269265201295548 NA NA NA hsa-miR-125b-5p AIFM1 -0.509303501421334 0.133265526313161 -0.329550499905558 0.0674559184109906 miRNATAP -0.223254137922591 7.72555568716759e-10 NA NA NA hsa-miR-143-5p AIFM1 -0.452341959646033 0.125356933437373 -0.329550499905558 0.0674559184109906 miRNATAP -0.109357237104709 0.0120808160008128 NA NA NA hsa-miR-145-5p AIFM1 -1.75133578902314 1.54965572197748e-05 -0.329550499905558 0.0674559184109906 miRNATAP -0.0965182161737635 0.00168998251703843 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-199a-5p AIFM1 0.371973504507027 0.232661597228763 -0.329550499905558 0.0674559184109906 miRanda -0.206809881643961 2.68432595992921e-07 NA NA NA hsa-miR-10a-5p AKT2 -0.470861534765518 0.148803248989189 -0.0135478038511252 0.922701697200587 mirMAP -0.0654370125941975 0.0303792663859316 NA NA NA hsa-miR-21-5p AKT2 1.75445050487988 2.41825549682022e-23 -0.0135478038511252 0.922701697200587 miRNAWalker2_validate -0.147206602823392 0.00352458167442573 NA NA NA hsa-miR-29a-3p AKT2 -0.113012156986374 0.615005009685815 -0.0135478038511252 0.922701697200587 MirTarget -0.0982437549673797 0.0273274722717801 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-29b-3p AKT2 -0.230693226193598 0.367461626035234 -0.0135478038511252 0.922701697200587 MirTarget -0.141689777106604 0.000224365237662475 26512921;26564501;24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis ;; ovarian cancer;gastric cancer;acute myeloid leukemia hsa-miR-29c-3p AKT2 -1.62454036584589 5.38376515586029e-07 -0.0135478038511252 0.922701697200587 MirTarget -0.0660531923041311 0.0252470288111568 NA NA NA hsa-miR-502-5p AKT2 -0.260297419808178 0.520453580478988 -0.0135478038511252 0.922701697200587 mirMAP -0.091157329410262 0.000164781703524308 NA NA NA hsa-miR-106b-5p AKT3 1.70863907461894 2.04074794107142e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.368902671357459 6.63579377990938e-05 NA NA NA hsa-miR-107 AKT3 0.904627575346218 4.67936495073904e-05 -0.748577301508132 0.0693608036068007 PITA;miRanda -0.596025797372068 4.38261497597827e-06 NA NA NA hsa-miR-15a-5p AKT3 1.03783090449383 7.40334108980898e-07 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.274970529297272 0.0488706353789957 NA NA NA hsa-miR-15b-5p AKT3 1.62046407540723 5.42152621571078e-09 -0.748577301508132 0.0693608036068007 miRNATAP -0.359857777182961 0.000407223981183838 NA NA NA hsa-miR-16-5p AKT3 1.00515772948091 5.33912942007619e-06 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.473860841884761 0.000305952592817196 NA NA NA hsa-miR-17-3p AKT3 1.31126744284937 3.24768335024185e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.520864813647553 2.25932722443508e-06 NA NA NA hsa-miR-17-5p AKT3 1.65862087862483 8.45603406215941e-08 -0.748577301508132 0.0693608036068007 TargetScan;miRNATAP -0.276276453758938 0.00270096970703173 NA NA NA hsa-miR-20a-5p AKT3 1.4503375861709 5.7813456424762e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.250292315132117 0.0116585363759179 NA NA NA hsa-miR-29a-3p AKT3 -0.113012156986374 0.615005009685815 -0.748577301508132 0.0693608036068007 miRNATAP -0.408748871699734 0.00212322174807936 NA NA NA hsa-miR-29b-3p AKT3 -0.230693226193598 0.367461626035234 -0.748577301508132 0.0693608036068007 miRNATAP -0.338134432146425 0.00361456599882575 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 -0.241623656423063 0.633116553078159 -0.748577301508132 0.0693608036068007 mirMAP -0.125422941319574 0.035934326995894 NA NA NA hsa-miR-32-3p AKT3 0.583525764322974 0.11837203008551 -0.748577301508132 0.0693608036068007 mirMAP -0.324144417685552 0.000230218736536503 NA NA NA hsa-miR-320b AKT3 1.11183660885284 0.000497971211648503 -0.748577301508132 0.0693608036068007 PITA;miRanda;miRNATAP -0.263235906209639 0.00390234919135454 NA NA NA hsa-miR-335-3p AKT3 2.5197689063267 2.20084506976733e-09 -0.748577301508132 0.0693608036068007 mirMAP -0.224460236877792 0.000742588100170571 NA NA NA hsa-miR-33a-3p AKT3 0.347011402017138 0.321709379745392 -0.748577301508132 0.0693608036068007 mirMAP -0.376513667394311 1.68302152281553e-05 NA NA NA hsa-miR-362-3p AKT3 -0.0349414695893027 0.913780708043777 -0.748577301508132 0.0693608036068007 miRanda -0.37545416085904 3.60412362584734e-05 NA NA NA hsa-miR-362-5p AKT3 -0.354508685915981 0.354912078595613 -0.748577301508132 0.0693608036068007 PITA;TargetScan;miRNATAP -0.231850776707854 0.00252522310690117 NA NA NA hsa-miR-3662 AKT3 1.82780708047676 0.0054036501346178 -0.748577301508132 0.0693608036068007 mirMAP -0.145733880594873 0.0112063480467946 NA NA NA hsa-miR-421 AKT3 1.80720854070385 1.59709651202848e-07 -0.748577301508132 0.0693608036068007 miRanda;mirMAP -0.21019033913331 0.0112381625122127 NA NA NA hsa-miR-424-5p AKT3 1.08509868581983 0.000420473853818268 -0.748577301508132 0.0693608036068007 miRNATAP -0.232817847879519 0.0142564549758907 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 0.731876211669996 0.0270421347018303 -0.748577301508132 0.0693608036068007 miRNATAP -0.389710500003727 8.30408434984544e-06 NA NA NA hsa-miR-502-3p AKT3 -0.16442685491191 0.557471818466728 -0.748577301508132 0.0693608036068007 miRNATAP -0.502835122914366 1.28261107693995e-06 NA NA NA hsa-miR-505-3p AKT3 0.82660100642669 0.00111666333288398 -0.748577301508132 0.0693608036068007 mirMAP -0.351999859841566 0.0023495079245673 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 -0.156004387355895 0.708665170641638 -0.748577301508132 0.0693608036068007 miRNATAP -0.26608196493585 0.000310856014668821 NA NA NA hsa-miR-577 AKT3 0.911619788986754 0.2256062124148 -0.748577301508132 0.0693608036068007 mirMAP -0.230357457399908 2.14832389488646e-09 NA NA NA hsa-miR-616-5p AKT3 0.834052908652744 0.0347835664029363 -0.748577301508132 0.0693608036068007 mirMAP -0.265580906698402 0.000411824587413266 NA NA NA hsa-miR-93-5p AKT3 1.7515174434778 1.59386482413883e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.196239002588412 0.0332091920754841 NA NA NA hsa-miR-23a-3p APAF1 1.10685926969665 3.16223452471768e-08 0.298695417693903 0.227685316305025 miRNATAP -0.491899186506395 3.94456341577364e-09 24992592;24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed ; colorectal cancer;colorectal cancer hsa-miR-23b-3p APAF1 -0.286465516491361 0.18664668472995 0.298695417693903 0.227685316305025 miRNATAP -0.541460697050492 5.01748351159025e-12 NA NA NA hsa-miR-27a-3p APAF1 1.29886998470345 2.68986118553486e-08 0.298695417693903 0.227685316305025 miRNATAP -0.390173318022615 4.7184175078605e-08 NA NA NA hsa-miR-27b-3p APAF1 0.0836323965901755 0.725273923274 0.298695417693903 0.227685316305025 miRNATAP -0.477647814500079 2.53647023848586e-11 NA NA NA hsa-miR-708-3p APAF1 0.623782703831307 0.275355868302311 0.298695417693903 0.227685316305025 mirMAP -0.239415264582338 2.50187362969727e-17 NA NA NA hsa-miR-944 APAF1 3.33123095809751 0.0177835044930391 0.298695417693903 0.227685316305025 miRNATAP -0.133026823389135 2.79320179778191e-24 NA NA NA hsa-miR-125a-3p ATM 1.19506542853853 0.00164364545717311 -0.394769053567885 0.0834135681853264 miRanda -0.132495092210333 0.00187961461837904 NA NA NA hsa-miR-203a-3p ATM 1.44736908507496 0.0394116388736904 -0.394769053567885 0.0834135681853264 MirTarget -0.138506783210379 2.82519981053352e-10 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-324-5p ATM 1.08820215809537 3.11674414561836e-05 -0.394769053567885 0.0834135681853264 miRanda -0.123502219615615 0.045230905693652 NA NA NA hsa-miR-34c-5p ATM 2.20632574870337 0.000379662996168678 -0.394769053567885 0.0834135681853264 miRanda -0.0561933988723923 0.0302577626090659 NA NA NA hsa-miR-590-5p ATM 1.04171442093217 0.000272475544954865 -0.394769053567885 0.0834135681853264 mirMAP -0.169733213019369 0.00247037314325533 NA NA NA hsa-miR-944 ATM 3.33123095809751 0.0177835044930391 -0.394769053567885 0.0834135681853264 mirMAP -0.0743112172624752 1.66179424281197e-08 NA NA NA hsa-miR-30a-5p BAX -1.71922855140016 3.20574349285256e-07 1.23402997413945 2.35105004724979e-11 miRNAWalker2_validate -0.14794228476148 0.000184560208965232 NA NA NA hsa-miR-365a-3p BAX -0.891537000455889 0.0025537650440002 1.23402997413945 2.35105004724979e-11 miRNAWalker2_validate -0.185079422057606 5.80881818302673e-05 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX drug resistance pancreatic cancer hsa-miR-15b-3p BCL2 1.75738933306437 3.00554466232543e-08 -1.09374208002759 0.00317080214601605 mirMAP -0.23817009094778 0.00334370547706688 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-2-3p BCL2 1.8048179609245 2.83095715136409e-09 -1.09374208002759 0.00317080214601605 mirMAP -0.256921078159685 0.0022954047853729 NA NA NA hsa-miR-17-5p BCL2 1.65862087862483 8.45603406215941e-08 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase -0.200242781422131 0.016758762742377 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181b-5p BCL2 1.64216500592669 1.89228845300725e-08 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase -0.220459527314755 0.0127096144577693 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-192-5p BCL2 0.0809146624034405 0.941057093528709 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate -0.0738310359860913 0.00226347107836944 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 5.58954708296963 1.12099152907987e-19 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate -0.0954192370232409 0.0146288165187003 NA NA NA hsa-miR-200a-5p BCL2 1.50371809098978 0.00263602434344863 -1.09374208002759 0.00317080214601605 mirMAP -0.211128800630803 4.95343554899065e-05 NA NA NA hsa-miR-200b-3p BCL2 0.974577911407732 0.0595020056914543 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.182246427033851 0.000341103736622929 NA NA NA hsa-miR-200b-5p BCL2 0.969871521250413 0.0530500454130183 -1.09374208002759 0.00317080214601605 mirMAP -0.205249290010733 0.000189759214886854 NA NA NA hsa-miR-200c-3p BCL2 1.28185685499076 0.00369777635539177 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;mirMAP -0.226804029845278 0.000126679308092617 NA NA NA hsa-miR-20a-3p BCL2 1.13957127410163 0.000451087640268489 -1.09374208002759 0.00317080214601605 mirMAP -0.220252577355485 0.00668844206923876 NA NA NA hsa-miR-21-5p BCL2 1.75445050487988 2.41825549682022e-23 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase -0.574405109042944 2.28190201261615e-05 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 0.715250240418615 0.573784317311889 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate -0.0705155418107827 0.000672403992452162 NA NA NA hsa-miR-24-2-5p BCL2 1.24948624677556 6.95051249640114e-07 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase -0.220461688537854 0.0344977414017145 NA NA NA hsa-miR-29a-5p BCL2 0.585084040404152 0.023014129158495 -1.09374208002759 0.00317080214601605 mirMAP -0.284870122627372 0.0062184185769466 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 -0.241623656423063 0.633116553078159 -1.09374208002759 0.00317080214601605 mirMAP -0.127759674715379 0.0180652856895953 NA NA NA hsa-miR-335-3p BCL2 2.5197689063267 2.20084506976733e-09 -1.09374208002759 0.00317080214601605 mirMAP -0.166369508302009 0.00598265233221658 NA NA NA hsa-miR-338-5p BCL2 -1.19659203838734 0.0100316010080496 -1.09374208002759 0.00317080214601605 PITA -0.118249149771179 0.0383033785997836 NA NA NA hsa-miR-34a-5p BCL2 0.794251341270032 0.00024017386701179 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase -0.271353080926629 0.0285451146052051 24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582;23862748 In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;;; breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-375 BCL2 -2.94506033785642 0.00570147601654791 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate -0.052534000071987 0.0338238313172429 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-429 BCL2 1.40182602301928 0.00900426780286475 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.202333078759473 3.04924059291668e-05 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-455-5p BCL2 1.20462751989145 6.74386011867484e-05 -1.09374208002759 0.00317080214601605 mirMAP -0.354129750010572 3.78782094978964e-05 NA NA NA hsa-miR-577 BCL2 0.911619788986754 0.2256062124148 -1.09374208002759 0.00317080214601605 PITA -0.10050287983592 0.00537086108513998 NA NA NA hsa-miR-590-3p BCL2 1.11654983899947 0.000160782154924864 -1.09374208002759 0.00317080214601605 miRanda;mirMAP -0.200073863178062 0.0252483459101818 NA NA NA hsa-miR-590-5p BCL2 1.04171442093217 0.000272475544954865 -1.09374208002759 0.00317080214601605 miRanda -0.195772286896467 0.0347215108084371 NA NA NA hsa-miR-7-1-3p BCL2 0.709309110750947 0.0412301737463194 -1.09374208002759 0.00317080214601605 mirMAP -0.19016039504681 0.0131974595106992 NA NA NA hsa-miR-7-5p BCL2 1.63575693499363 0.0124424214624534 -1.09374208002759 0.00317080214601605 miRNAWalker2_validate;miRTarBase;mirMAP -0.142794989912626 0.000680645769025094 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7b-5p BCL2L1 0.0582902155815681 0.781400138984745 0.213751739166448 0.395782450784369 miRNATAP -0.314285217081765 0.000268924662830079 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7c-5p BCL2L1 -0.503482361446512 0.206848395212976 0.213751739166448 0.395782450784369 miRNAWalker2_validate;miRTarBase -0.198493465039984 6.59628301755695e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-let-7i-5p BCL2L1 0.798954594465461 2.99735653959449e-05 0.213751739166448 0.395782450784369 miRNATAP -0.205547668191247 0.0288291594619706 NA NA NA hsa-miR-133a-3p BCL2L1 -3.07408796787523 8.17423849601445e-07 0.213751739166448 0.395782450784369 miRNAWalker2_validate -0.081384627661805 0.00327890017458848 23756231 Furthermore bioinformatic prediction and experimental validation were applied to identify target genes of miR-133a and the results revealed that the anti-tumor effect of miR-133a was probably due to targeting and repressing of Bcl-xL and Mcl-1 expression sarcoma hsa-miR-149-5p BCL2L1 0.706277554734069 0.296848731347677 0.213751739166448 0.395782450784369 mirMAP -0.173000301400021 4.12180118165392e-12 NA NA NA hsa-miR-214-3p BCL2L1 1.01201534142544 0.00625092909225755 0.213751739166448 0.395782450784369 mirMAP -0.12678075713813 0.00823737366000966 NA NA NA hsa-miR-23b-3p BCL2L1 -0.286465516491361 0.18664668472995 0.213751739166448 0.395782450784369 miRNAWalker2_validate -0.389042865664013 2.23464331013867e-06 NA NA NA hsa-miR-342-3p BCL2L1 0.318119432680668 0.269150960124243 0.213751739166448 0.395782450784369 PITA;miRanda;miRNATAP -0.153115280709334 0.0144837016137543 NA NA NA hsa-miR-624-5p BIRC2 1.03467956701702 0.0010908013402586 0.152226269311783 0.344075610424225 MirTarget -0.0802988334667712 0.0334364784780824 NA NA NA hsa-miR-24-2-5p BIRC3 1.24948624677556 6.95051249640114e-07 -0.429401036650259 0.444925319802684 MirTarget -0.401342364994434 0.0102117502895027 NA NA NA hsa-miR-28-3p BIRC3 -0.730670593501133 0.000351503999708671 -0.429401036650259 0.444925319802684 MirTarget -0.395625181651202 0.045669666916569 NA NA NA hsa-miR-369-3p BIRC3 0.32261175629684 0.3589927609891 -0.429401036650259 0.444925319802684 MirTarget;miRNATAP -0.259349743129328 0.0235331229376535 NA NA NA hsa-miR-496 BIRC3 0.569160795971369 0.163412434313533 -0.429401036650259 0.444925319802684 mirMAP -0.240804213141557 0.0334800415390581 NA NA NA hsa-miR-651-5p BIRC3 0.668780396585739 0.0600532880935192 -0.429401036650259 0.444925319802684 MirTarget -0.250394817111564 0.0277874479741334 NA NA NA hsa-miR-491-5p CAPN1 -0.693578126269305 0.0313646742330058 0.46710889632859 0.0478649092769723 miRanda -0.184673486668961 0.000496187970468952 NA NA NA hsa-miR-107 CAPN2 0.904627575346218 4.67936495073904e-05 -0.586663057719878 0.00617400395352454 miRanda -0.197768883350134 0.00394907266083995 NA NA NA hsa-miR-20a-3p CAPN2 1.13957127410163 0.000451087640268489 -0.586663057719878 0.00617400395352454 MirTarget -0.114291546824966 0.0144927731036964 NA NA NA hsa-miR-320a CAPN2 0.593888711838028 0.011897419390526 -0.586663057719878 0.00617400395352454 miRanda -0.258289986910646 6.42445165326642e-05 NA NA NA hsa-miR-320b CAPN2 1.11183660885284 0.000497971211648503 -0.586663057719878 0.00617400395352454 miRanda -0.164820430492686 0.000480039367141294 NA NA NA hsa-miR-421 CAPN2 1.80720854070385 1.59709651202848e-07 -0.586663057719878 0.00617400395352454 miRanda -0.181112317538687 2.00714893454957e-05 NA NA NA hsa-miR-7-5p CAPN2 1.63575693499363 0.0124424214624534 -0.586663057719878 0.00617400395352454 miRNAWalker2_validate -0.0630295887657738 0.00949733713816609 NA NA NA hsa-miR-125b-5p CASP10 -0.509303501421334 0.133265526313161 0.324838353536535 0.449881772912426 mirMAP -0.449087306744439 3.61566839470125e-07 NA NA NA hsa-miR-129-5p CASP10 -2.56914016541176 2.36237896095709e-06 0.324838353536535 0.449881772912426 mirMAP -0.153611209701923 0.00569612745338825 NA NA NA hsa-miR-145-3p CASP10 -1.64531410450617 1.69916538962193e-05 0.324838353536535 0.449881772912426 mirMAP -0.218540289944103 0.00524822997508139 NA NA NA hsa-miR-145-5p CASP10 -1.75133578902314 1.54965572197748e-05 0.324838353536535 0.449881772912426 mirMAP -0.212093598244869 0.00404223124849514 NA NA NA hsa-miR-34c-3p CASP10 2.25273698056457 9.06191072601281e-05 0.324838353536535 0.449881772912426 mirMAP -0.31620449305764 4.34162369825633e-10 NA NA NA hsa-miR-374a-3p CASP10 0.0420912023953779 0.851478041312794 0.324838353536535 0.449881772912426 mirMAP -0.311166163388005 0.0252345588956442 NA NA NA hsa-miR-452-5p CASP10 2.08756506185889 0.000258095769002813 0.324838353536535 0.449881772912426 mirMAP -0.282928083510076 2.93087174018704e-08 NA NA NA hsa-miR-744-3p CASP10 1.40439584998788 0.000973603203532439 0.324838353536535 0.449881772912426 mirMAP -0.351511141760014 4.23229368717493e-07 NA NA NA hsa-let-7b-5p CASP3 0.0582902155815681 0.781400138984745 0.561485688223755 0.000745753526927612 MirTarget;miRNATAP -0.114591006373253 0.0489768742322708 NA NA NA hsa-let-7c-5p CASP3 -0.503482361446512 0.206848395212976 0.561485688223755 0.000745753526927612 MirTarget -0.094822260714891 0.00143504424063517 NA NA NA hsa-miR-129-5p CASP3 -2.56914016541176 2.36237896095709e-06 0.561485688223755 0.000745753526927612 mirMAP -0.0697580330014447 0.00120407365948845 23744359 The intrinsic apoptotic pathway triggered by miR-129 was activated by cleavage of caspase-9 and caspase-3 colorectal cancer hsa-miR-193b-5p CASP3 0.609581100028941 0.13923921336815 0.561485688223755 0.000745753526927612 MirTarget -0.0930660127382365 0.00119994390473118 NA NA NA hsa-miR-369-3p CASP6 0.32261175629684 0.3589927609891 0.386023658973223 0.0927586687174801 MirTarget -0.113129078464786 0.0153110314193734 NA NA NA hsa-miR-129-5p CASP7 -2.56914016541176 2.36237896095709e-06 0.221699714130274 0.301273280139001 miRanda -0.0601101111516168 0.0300316072444682 NA NA NA hsa-miR-23b-3p CASP7 -0.286465516491361 0.18664668472995 0.221699714130274 0.301273280139001 MirTarget -0.193386816394858 0.00670740113208553 NA NA NA hsa-miR-9-3p CASP7 0.330346058941473 0.541111939982661 0.221699714130274 0.301273280139001 MirTarget -0.101221266430696 0.000505068364865864 NA NA NA hsa-miR-129-5p CASP8 -2.56914016541176 2.36237896095709e-06 1.08073884606891 5.24067403889636e-07 miRanda -0.14203060790996 3.69274761688692e-07 NA NA NA hsa-miR-143-3p CASP8 -0.661937718854688 0.0483213962135842 1.08073884606891 5.24067403889636e-07 MirTarget -0.193498599025905 3.01762109778414e-05 NA NA NA hsa-miR-20b-5p CASP8 -0.750137369661989 0.137699447213685 1.08073884606891 5.24067403889636e-07 MirTarget -0.0624373591478867 0.0458672180156108 NA NA NA hsa-miR-193b-3p CASP9 0.281752012268679 0.451258902263119 -0.314756842171161 0.110040278687801 miRNAWalker2_validate -0.173981251979618 2.15802379337291e-06 NA NA NA hsa-miR-103a-2-5p CFLAR 0.808041560899298 0.019989162317947 0.0720322851418542 0.738188372927117 mirMAP -0.110803997702137 0.0117705752455865 NA NA NA hsa-miR-130a-3p CFLAR 0.146223920674657 0.633739795905839 0.0720322851418542 0.738188372927117 mirMAP -0.143102232833246 0.0042096005919206 NA NA NA hsa-miR-130b-3p CFLAR 1.32714007211004 4.78676252285191e-05 0.0720322851418542 0.738188372927117 mirMAP -0.210127485723908 3.30780313901517e-06 NA NA NA hsa-miR-15b-5p CFLAR 1.62046407540723 5.42152621571078e-09 0.0720322851418542 0.738188372927117 mirMAP -0.216364599318049 3.69635651871987e-05 NA NA NA hsa-miR-16-5p CFLAR 1.00515772948091 5.33912942007619e-06 0.0720322851418542 0.738188372927117 mirMAP -0.170923989310882 0.0127430662137196 NA NA NA hsa-miR-224-3p CFLAR 1.52422171450716 0.00650463542340912 0.0720322851418542 0.738188372927117 mirMAP -0.093750586170218 0.0014487038871828 NA NA NA hsa-miR-224-5p CFLAR 2.7648036144402 0.000111736336240167 0.0720322851418542 0.738188372927117 MirTarget -0.0630031418239656 0.00246093489001826 NA NA NA hsa-miR-301a-3p CFLAR 1.44721900431161 6.35068481036652e-06 0.0720322851418542 0.738188372927117 mirMAP -0.200905622703673 1.22637297314175e-05 NA NA NA hsa-miR-320b CFLAR 1.11183660885284 0.000497971211648503 0.0720322851418542 0.738188372927117 miRanda -0.105599339617207 0.0261273650564973 NA NA NA hsa-miR-320c CFLAR 0.455072851945474 0.240613785444485 0.0720322851418542 0.738188372927117 miRanda -0.106903295107419 0.0194293513909834 NA NA NA hsa-miR-34c-5p CFLAR 2.20632574870337 0.000379662996168678 0.0720322851418542 0.738188372927117 miRanda -0.0890845640209413 0.00022151679160677 NA NA NA hsa-miR-455-5p CFLAR 1.20462751989145 6.74386011867484e-05 0.0720322851418542 0.738188372927117 miRanda -0.0988877950544523 0.0481547759223391 NA NA NA hsa-miR-484 CFLAR 0.71327898984355 0.00233605130771196 0.0720322851418542 0.738188372927117 mirMAP -0.164649012228087 0.0118977837816939 NA NA NA hsa-miR-708-5p CFLAR 1.41830449251856 0.0109647946476309 0.0720322851418542 0.738188372927117 mirMAP -0.0978648232617609 0.000273032401499298 NA NA NA hsa-miR-9-5p CFLAR -0.195328736653048 0.761470692992178 0.0720322851418542 0.738188372927117 mirMAP -0.129368546803925 1.64710267403862e-08 NA NA NA hsa-miR-152-3p CHUK 0.436002345388935 0.161701199884702 -0.111597771177896 0.436110414435051 MirTarget -0.173337618013613 3.78615463498576e-08 NA NA NA hsa-miR-195-5p CHUK -0.907998841926297 0.00150511564650591 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;MirTarget -0.133199766126432 0.000124702259663161 NA NA NA hsa-miR-23a-3p CHUK 1.10685926969665 3.16223452471768e-08 -0.111597771177896 0.436110414435051 MirTarget -0.16996459977061 0.000556739825154491 NA NA NA hsa-miR-23b-3p CHUK -0.286465516491361 0.18664668472995 -0.111597771177896 0.436110414435051 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.186735010864747 6.42002077885917e-05 NA NA NA hsa-miR-342-3p CHUK 0.318119432680668 0.269150960124243 -0.111597771177896 0.436110414435051 miRanda -0.186912661037413 4.74504057766316e-08 NA NA NA hsa-miR-376c-3p CHUK -0.0202687695094781 0.953448994947367 -0.111597771177896 0.436110414435051 MirTarget -0.0761342578966379 0.0091803822964989 NA NA NA hsa-miR-497-5p CHUK -0.801030912431774 0.00360386743876612 -0.111597771177896 0.436110414435051 MirTarget -0.109322835458534 0.00272843002977532 NA NA NA hsa-miR-655-3p CHUK 0.296138114843761 0.396423764161133 -0.111597771177896 0.436110414435051 MirTarget -0.079757548444758 0.00609041948369557 NA NA NA hsa-miR-15b-3p CSF2RB 1.75738933306437 3.00554466232543e-08 -0.200137813184114 0.596568526131504 mirMAP -0.312420406243405 0.000120694089204471 NA NA NA hsa-miR-19a-3p CSF2RB 1.26669687448473 0.000105972838514412 -0.200137813184114 0.596568526131504 MirTarget -0.178488404603662 0.0284092516220589 NA NA NA hsa-miR-30b-3p CSF2RB -0.266398938200332 0.400847813143994 -0.200137813184114 0.596568526131504 MirTarget -0.245556903717171 0.003931259065523 NA NA NA hsa-miR-452-3p CSF2RB 2.2028815467959 0.00185370432491004 -0.200137813184114 0.596568526131504 mirMAP -0.133306575465583 0.0015572310697747 NA NA NA hsa-miR-455-5p CSF2RB 1.20462751989145 6.74386011867484e-05 -0.200137813184114 0.596568526131504 miRanda -0.19730913043501 0.0250819374847068 NA NA NA hsa-miR-576-5p CSF2RB 0.625714137488957 0.0417100301848969 -0.200137813184114 0.596568526131504 miRNATAP -0.179681973548941 0.0412348713645336 NA NA NA hsa-miR-342-3p CYCS 0.318119432680668 0.269150960124243 0.195262771266198 0.359129576262205 mirMAP -0.206285282933732 7.83163671388272e-05 NA NA NA hsa-miR-155-5p DFFA 1.28707757465885 8.6344688246758e-05 0.0120370172509965 0.934238830694791 mirMAP -0.0671671340662621 0.0298204272267054 NA NA NA hsa-miR-342-3p DFFA 0.318119432680668 0.269150960124243 0.0120370172509965 0.934238830694791 mirMAP -0.102006639384243 0.00439905570386533 NA NA NA hsa-miR-199a-5p DFFB 0.371973504507027 0.232661597228763 0.212840421957756 0.407842476169045 miRanda -0.20194549347049 0.000557924406397779 NA NA NA hsa-miR-199b-5p DFFB 0.124595928096068 0.678156859366405 0.212840421957756 0.407842476169045 miRanda -0.161280275487813 0.00849920247295308 NA NA NA hsa-miR-28-5p DFFB -0.238617853755144 0.167318538669818 0.212840421957756 0.407842476169045 miRanda -0.252610844833049 0.0209912668248774 NA NA NA hsa-miR-365a-3p DFFB -0.891537000455889 0.0025537650440002 0.212840421957756 0.407842476169045 MirTarget -0.41279484896589 1.43247424506894e-12 NA NA NA hsa-miR-129-5p ENDOD1 -2.56914016541176 2.36237896095709e-06 0.173942577209361 0.52051984762621 MirTarget;miRanda -0.0861751621847609 0.0137116030219307 NA NA NA hsa-miR-130b-3p ENDOD1 1.32714007211004 4.78676252285191e-05 0.173942577209361 0.52051984762621 MirTarget -0.221529929695622 0.0001138681713791 NA NA NA hsa-miR-16-1-3p ENDOD1 1.43227522002564 3.70920454953168e-08 0.173942577209361 0.52051984762621 mirMAP -0.213654091575809 0.00290185056658808 NA NA NA hsa-miR-181a-5p ENDOD1 1.39227281909646 1.91689469974826e-09 0.173942577209361 0.52051984762621 MirTarget -0.191241701702027 0.017669695461631 NA NA NA hsa-miR-181b-5p ENDOD1 1.64216500592669 1.89228845300725e-08 0.173942577209361 0.52051984762621 MirTarget -0.173013375351316 0.00661465257144989 NA NA NA hsa-miR-181c-5p ENDOD1 0.336826967681288 0.112932307913601 0.173942577209361 0.52051984762621 MirTarget -0.265174587977321 0.00393087804819997 NA NA NA hsa-miR-181d-5p ENDOD1 0.65192727601808 0.0143398117228333 0.173942577209361 0.52051984762621 MirTarget -0.214053420402313 0.00307279912997386 NA NA NA hsa-miR-192-5p ENDOD1 0.0809146624034405 0.941057093528709 0.173942577209361 0.52051984762621 miRNAWalker2_validate -0.0642408803298844 0.000211630945831834 NA NA NA hsa-miR-19a-3p ENDOD1 1.26669687448473 0.000105972838514412 0.173942577209361 0.52051984762621 mirMAP -0.271910605269385 1.74353363266121e-06 NA NA NA hsa-miR-19b-3p ENDOD1 0.759818275708988 0.00652779573186786 0.173942577209361 0.52051984762621 mirMAP -0.330017482149238 9.60364137393709e-07 NA NA NA hsa-miR-200b-3p ENDOD1 0.974577911407732 0.0595020056914543 0.173942577209361 0.52051984762621 TargetScan -0.083893577004521 0.0235909911306784 NA NA NA hsa-miR-20a-3p ENDOD1 1.13957127410163 0.000451087640268489 0.173942577209361 0.52051984762621 MirTarget -0.237417432714634 4.07430637853666e-05 NA NA NA hsa-miR-26b-3p ENDOD1 -0.0103961389461977 0.965770899625511 0.173942577209361 0.52051984762621 mirMAP -0.389217407061445 7.7901649421167e-07 NA NA NA hsa-miR-301a-3p ENDOD1 1.44721900431161 6.35068481036652e-06 0.173942577209361 0.52051984762621 MirTarget -0.174551469878144 0.00291477854957477 NA NA NA hsa-miR-301b-3p ENDOD1 1.10080095582241 0.0715568440482997 0.173942577209361 0.52051984762621 MirTarget -0.105991855921781 0.0136058352836711 NA NA NA hsa-miR-326 ENDOD1 -0.429748586406214 0.2629894124021 0.173942577209361 0.52051984762621 miRanda -0.179053179666302 0.000372552467984529 NA NA NA hsa-miR-335-3p ENDOD1 2.5197689063267 2.20084506976733e-09 0.173942577209361 0.52051984762621 MirTarget -0.17740021575613 3.89969765893599e-05 NA NA NA hsa-miR-3607-3p ENDOD1 0.522750552658156 0.0842510989344654 0.173942577209361 0.52051984762621 MirTarget;miRNATAP -0.251093379289001 6.74689951520392e-05 NA NA NA hsa-miR-361-5p ENDOD1 0.407725414130987 0.0181260969156347 0.173942577209361 0.52051984762621 MirTarget;miRanda -0.416537686793062 0.00024695083695521 NA NA NA hsa-miR-3613-5p ENDOD1 1.11821523851438 0.000249706750761735 0.173942577209361 0.52051984762621 MirTarget -0.254290031486541 3.59830825075084e-05 NA NA NA hsa-miR-362-3p ENDOD1 -0.0349414695893027 0.913780708043777 0.173942577209361 0.52051984762621 miRanda -0.151004977445326 0.01205633093671 NA NA NA hsa-miR-3662 ENDOD1 1.82780708047676 0.0054036501346178 0.173942577209361 0.52051984762621 MirTarget;miRNATAP -0.0960205989103092 0.0104589321027774 NA NA NA hsa-miR-429 ENDOD1 1.40182602301928 0.00900426780286475 0.173942577209361 0.52051984762621 miRanda;miRNATAP -0.0867374002973715 0.0145879562667488 NA NA NA hsa-miR-450b-5p ENDOD1 0.46157963033014 0.13273722727895 0.173942577209361 0.52051984762621 MirTarget;mirMAP -0.172393535004454 0.0060845153825999 NA NA NA hsa-miR-454-3p ENDOD1 0.625199142970745 0.0134890997402741 0.173942577209361 0.52051984762621 MirTarget -0.40647578762712 4.22203950311284e-08 NA NA NA hsa-miR-589-3p ENDOD1 1.01962606923682 0.00577853347252709 0.173942577209361 0.52051984762621 mirMAP -0.22624680676427 8.66124289089138e-06 NA NA NA hsa-miR-589-5p ENDOD1 0.702695092403762 0.00395772685954799 0.173942577209361 0.52051984762621 MirTarget -0.317235684709577 4.95639850060221e-05 NA NA NA hsa-miR-590-3p ENDOD1 1.11654983899947 0.000160782154924864 0.173942577209361 0.52051984762621 miRanda -0.270082396760333 2.04706660293418e-05 NA NA NA hsa-miR-149-5p EXOG 0.706277554734069 0.296848731347677 -0.162295093538277 0.334751390384514 MirTarget -0.100190512100333 2.75690635023969e-09 NA NA NA hsa-miR-200c-3p EXOG 1.28185685499076 0.00369777635539177 -0.162295093538277 0.334751390384514 MirTarget -0.0869184637208132 0.00103894517078443 NA NA NA hsa-miR-24-3p EXOG 1.08578167539644 6.18549359075268e-07 -0.162295093538277 0.334751390384514 MirTarget -0.205017755650949 0.000120305772178939 NA NA NA hsa-miR-129-5p FADD -2.56914016541176 2.36237896095709e-06 1.34054312587879 0.000321450092241079 miRanda -0.174823490854185 0.000319064240302471 NA NA NA hsa-miR-7-5p FADD 1.63575693499363 0.0124424214624534 1.34054312587879 0.000321450092241079 miRNAWalker2_validate -0.123581882815797 0.00376774438421864 NA NA NA hsa-miR-106a-5p FAS -0.173255688252641 0.642872703263671 0.657268335933371 0.0207009292820455 miRNAWalker2_validate;miRTarBase -0.15547134509945 0.00429149494899305 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-129-5p FAS -2.56914016541176 2.36237896095709e-06 0.657268335933371 0.0207009292820455 miRanda -0.124419506861282 0.000695154070004086 NA NA NA hsa-miR-92b-3p FASLG 1.33518446513417 1.45350885391576e-06 0.493896235569131 0.390001245956277 miRNATAP -0.542744180708012 0.000155394781632395 NA NA NA hsa-miR-125a-3p IKBKB 1.19506542853853 0.00164364545717311 0.134870081917275 0.507473312093685 miRanda -0.128753900358831 0.000649508610645324 NA NA NA hsa-miR-125a-5p IKBKB -0.878090699011564 0.000213630844319685 0.134870081917275 0.507473312093685 miRanda -0.124186488819957 0.0412246672043188 NA NA NA hsa-miR-218-5p IKBKB -0.987730614742492 0.0108295837207062 0.134870081917275 0.507473312093685 miRNAWalker2_validate;miRTarBase -0.0795864357160866 0.0317678237322372 NA NA NA hsa-miR-339-5p IKBKB 0.770566566962108 0.00816529093411862 0.134870081917275 0.507473312093685 miRanda -0.109663780276872 0.026931994797365 NA NA NA hsa-miR-491-5p IKBKB -0.693578126269305 0.0313646742330058 0.134870081917275 0.507473312093685 miRanda -0.102720727542062 0.0250079054091346 NA NA NA hsa-miR-543 IKBKB 0.0323775903217254 0.929458442755522 0.134870081917275 0.507473312093685 miRanda -0.128643682904471 0.00308168626813573 NA NA NA hsa-miR-125a-5p IKBKG -0.878090699011564 0.000213630844319685 0.482871701565075 0.00797160760932323 miRanda -0.235137534713953 1.20912221589607e-05 NA NA NA hsa-miR-148a-3p IKBKG -1.53721533763578 3.55533747293117e-05 0.482871701565075 0.00797160760932323 mirMAP -0.11630876600781 0.000633185783589711 NA NA NA hsa-miR-29c-3p IKBKG -1.62454036584589 5.38376515586029e-07 0.482871701565075 0.00797160760932323 mirMAP -0.0906628936343448 0.0202963867688418 NA NA NA hsa-miR-191-5p IL1A 0.964929997847221 0.000706019788557095 3.98706567663546 1.16849910667626e-05 miRNAWalker2_validate -0.695822638582492 0.00261744460155118 NA NA NA hsa-miR-200a-3p IL1A 0.717826667295984 0.193912116506827 3.98706567663546 1.16849910667626e-05 MirTarget -0.340606001845334 0.00439380383654693 NA NA NA hsa-miR-30a-5p IL1A -1.71922855140016 3.20574349285256e-07 3.98706567663546 1.16849910667626e-05 MirTarget -0.814660149177838 1.64588406524699e-05 NA NA NA hsa-miR-30b-5p IL1A -0.430720743745757 0.0593564057320791 3.98706567663546 1.16849910667626e-05 MirTarget -0.946999569898049 0.00123879394096619 NA NA NA hsa-miR-30c-5p IL1A -0.983130268805942 4.60419218706127e-05 3.98706567663546 1.16849910667626e-05 MirTarget -1.11897157505593 3.38735639049494e-05 NA NA NA hsa-miR-30d-5p IL1A -0.5492586056147 0.0140125082460125 3.98706567663546 1.16849910667626e-05 MirTarget -1.69859525858947 4.69234742994376e-09 NA NA NA hsa-miR-30e-5p IL1A -0.573784818166736 0.0112497802572927 3.98706567663546 1.16849910667626e-05 MirTarget -0.834034959769621 0.0048151786715307 NA NA NA hsa-miR-532-5p IL1A 0.313080805824184 0.252248939356301 3.98706567663546 1.16849910667626e-05 MirTarget -1.08391384408926 6.80635936079074e-06 NA NA NA hsa-miR-664a-3p IL1A -0.83041219170254 0.000136267547251167 3.98706567663546 1.16849910667626e-05 MirTarget -0.897367435115216 0.00322501864839319 NA NA NA hsa-miR-30a-3p IL1B -1.73205137750899 3.2425754511091e-07 1.26826196984759 0.0328751494712569 MirTarget -0.435934837553166 0.000319780723167766 NA NA NA hsa-miR-126-5p IL1R1 0.41765430251855 0.0753161203651532 -0.906995887568108 0.0047158045114454 mirMAP -0.261436359372816 0.00849952221113025 NA NA NA hsa-miR-130b-5p IL1R1 0.701350393759937 0.0510142718395002 -0.906995887568108 0.0047158045114454 mirMAP -0.368233556139774 2.48100078929972e-09 NA NA NA hsa-miR-17-3p IL1R1 1.31126744284937 3.24768335024185e-07 -0.906995887568108 0.0047158045114454 mirMAP -0.693802269428868 9.46806918483647e-18 NA NA NA hsa-miR-181b-5p IL1R1 1.64216500592669 1.89228845300725e-08 -0.906995887568108 0.0047158045114454 mirMAP -0.183222016716212 0.0166613739131917 NA NA NA hsa-miR-186-5p IL1R1 0.149964130725901 0.434709542998771 -0.906995887568108 0.0047158045114454 mirMAP -0.443167338337515 0.000291088595010789 NA NA NA hsa-miR-192-5p IL1R1 0.0809146624034405 0.941057093528709 -0.906995887568108 0.0047158045114454 miRNAWalker2_validate -0.0607539020358982 0.00369591066220573 NA NA NA hsa-miR-197-3p IL1R1 0.888854270009261 0.000195183808214449 -0.906995887568108 0.0047158045114454 miRNAWalker2_validate -0.49613040391323 1.22192346297885e-07 NA NA NA hsa-miR-215-5p IL1R1 0.715250240418615 0.573784317311889 -0.906995887568108 0.0047158045114454 miRNAWalker2_validate -0.0644588835031111 0.000315331657429739 NA NA NA hsa-miR-24-3p IL1R1 1.08578167539644 6.18549359075268e-07 -0.906995887568108 0.0047158045114454 miRNATAP -0.424471721385594 3.86777071307179e-05 NA NA NA hsa-miR-26b-5p IL1R1 -0.301646326928219 0.160081421968103 -0.906995887568108 0.0047158045114454 mirMAP -0.459757391461702 1.97133609463222e-05 NA NA NA hsa-miR-30d-3p IL1R1 -0.545113326540761 0.0433733076874155 -0.906995887568108 0.0047158045114454 mirMAP -0.230736331537232 0.00720309202491904 NA NA NA hsa-miR-335-3p IL1R1 2.5197689063267 2.20084506976733e-09 -0.906995887568108 0.0047158045114454 mirMAP -0.316316666355703 3.02394356078111e-10 NA NA NA hsa-miR-361-5p IL1R1 0.407725414130987 0.0181260969156347 -0.906995887568108 0.0047158045114454 miRanda -0.649361583840372 1.38224165077047e-06 NA NA NA hsa-miR-3662 IL1R1 1.82780708047676 0.0054036501346178 -0.906995887568108 0.0047158045114454 mirMAP -0.139395164254141 0.00185011658369509 NA NA NA hsa-miR-590-3p IL1R1 1.11654983899947 0.000160782154924864 -0.906995887568108 0.0047158045114454 miRanda;miRNATAP -0.32389995746728 2.02766398681884e-05 NA NA NA hsa-miR-107 IL1RAP 0.904627575346218 4.67936495073904e-05 1.19905493101495 0.00708677122236795 miRanda -0.72498660799915 2.20472801659065e-07 NA NA NA hsa-miR-139-5p IL1RAP -1.83374360776637 1.22019901002824e-09 1.19905493101495 0.00708677122236795 miRanda -0.272547372839431 0.00746891159879681 NA NA NA hsa-miR-140-5p IL1RAP 0.208193069681326 0.303002433893804 1.19905493101495 0.00708677122236795 miRanda -0.512055041931575 0.00149509182166155 NA NA NA hsa-miR-186-5p IL1RAP 0.149964130725901 0.434709542998771 1.19905493101495 0.00708677122236795 mirMAP -0.537551690584275 0.00161371725040932 NA NA NA hsa-miR-190a-5p IL1RAP -0.735154513525545 0.0662435769685494 1.19905493101495 0.00708677122236795 MirTarget -0.388835397731966 6.50096005244398e-07 NA NA NA hsa-miR-192-5p IL1RAP 0.0809146624034405 0.941057093528709 1.19905493101495 0.00708677122236795 miRNAWalker2_validate -0.26340817515093 1.8269423898969e-24 NA NA NA hsa-miR-215-5p IL1RAP 0.715250240418615 0.573784317311889 1.19905493101495 0.00708677122236795 miRNAWalker2_validate -0.213341497430021 3.63405666713444e-21 NA NA NA hsa-miR-217 IL1RAP -0.0121404731225336 0.980818372851502 1.19905493101495 0.00708677122236795 miRanda -0.129965445888147 0.0407715991555221 NA NA NA hsa-miR-29a-3p IL1RAP -0.113012156986374 0.615005009685815 1.19905493101495 0.00708677122236795 MirTarget;miRNATAP -0.544976271762727 0.000147042224820427 NA NA NA hsa-miR-29b-3p IL1RAP -0.230693226193598 0.367461626035234 1.19905493101495 0.00708677122236795 MirTarget;miRNATAP -0.388175128819188 0.00207019887859382 NA NA NA hsa-miR-29c-3p IL1RAP -1.62454036584589 5.38376515586029e-07 1.19905493101495 0.00708677122236795 MirTarget;miRNATAP -0.389730731662364 4.02368962835987e-05 NA NA NA hsa-miR-335-3p IL1RAP 2.5197689063267 2.20084506976733e-09 1.19905493101495 0.00708677122236795 mirMAP -0.196692209121667 0.00677610742244957 NA NA NA hsa-miR-362-3p IL1RAP -0.0349414695893027 0.913780708043777 1.19905493101495 0.00708677122236795 miRanda -0.316916214451342 0.00145990514687848 NA NA NA hsa-miR-375 IL1RAP -2.94506033785642 0.00570147601654791 1.19905493101495 0.00708677122236795 miRNAWalker2_validate;miRanda -0.230371011043722 3.36076494532311e-17 NA NA NA hsa-miR-577 IL1RAP 0.911619788986754 0.2256062124148 1.19905493101495 0.00708677122236795 mirMAP -0.21893322278354 2.22851674765636e-07 NA NA NA hsa-miR-7-1-3p IL1RAP 0.709309110750947 0.0412301737463194 1.19905493101495 0.00708677122236795 MirTarget -0.420546367243074 3.15641182707541e-06 NA NA NA hsa-miR-95-3p IL1RAP 1.04418546668769 0.0239737000737066 1.19905493101495 0.00708677122236795 MirTarget -0.179669790121027 0.00932523018097376 NA NA NA hsa-miR-328-3p IRAK1 -0.380419131085598 0.160877064911118 0.996529241553426 2.14119350751043e-06 miRNAWalker2_validate -0.113318029584029 0.0474387227064539 NA NA NA hsa-miR-3065-5p IRAK2 -0.241623656423063 0.633116553078159 1.3633351101708 0.00182765976046462 mirMAP -0.173330265376889 0.00653878581349746 NA NA NA hsa-miR-34c-5p IRAK2 2.20632574870337 0.000379662996168678 1.3633351101708 0.00182765976046462 miRanda -0.190933511899634 0.000123781852765921 NA NA NA hsa-miR-141-3p IRAK3 1.45548825076434 0.00115958850961764 -1.28292278880275 0.00693377483778813 mirMAP -0.164259986595488 0.0294440144995245 NA NA NA hsa-miR-205-5p IRAK3 3.13520672931882 0.0293226471971167 -1.28292278880275 0.00693377483778813 mirMAP -0.126832150752964 2.76094312601068e-08 NA NA NA hsa-miR-20a-3p IRAK3 1.13957127410163 0.000451087640268489 -1.28292278880275 0.00693377483778813 mirMAP -0.411339623078655 6.35608203513098e-05 NA NA NA hsa-miR-224-3p IRAK3 1.52422171450716 0.00650463542340912 -1.28292278880275 0.00693377483778813 mirMAP -0.287944944449608 9.58373092963594e-06 NA NA NA hsa-miR-3200-3p IRAK3 0.93510295722357 0.0984236007399256 -1.28292278880275 0.00693377483778813 mirMAP -0.214678925912326 0.0012779879321413 NA NA NA hsa-miR-324-5p IRAK3 1.08820215809537 3.11674414561836e-05 -1.28292278880275 0.00693377483778813 miRanda -0.439994098624388 0.000617531696828729 NA NA NA hsa-miR-335-3p IRAK3 2.5197689063267 2.20084506976733e-09 -1.28292278880275 0.00693377483778813 mirMAP -0.267472860372498 0.000518863463965078 NA NA NA hsa-miR-33a-5p IRAK3 0.407757858040717 0.321429014317207 -1.28292278880275 0.00693377483778813 mirMAP -0.373889424975974 4.55782863945046e-06 NA NA NA hsa-miR-33b-5p IRAK3 0.267227362818466 0.614814331176942 -1.28292278880275 0.00693377483778813 mirMAP -0.184942683105143 0.0265746805045233 NA NA NA hsa-miR-361-5p IRAK3 0.407725414130987 0.0181260969156347 -1.28292278880275 0.00693377483778813 miRanda;mirMAP -0.664237197745782 0.00103666478118959 NA NA NA hsa-miR-421 IRAK3 1.80720854070385 1.59709651202848e-07 -1.28292278880275 0.00693377483778813 miRanda;mirMAP -0.257256919163978 0.00737409919690172 NA NA NA hsa-miR-452-3p IRAK3 2.2028815467959 0.00185370432491004 -1.28292278880275 0.00693377483778813 mirMAP -0.287307763504979 3.49213014236789e-08 NA NA NA hsa-miR-590-5p IRAK3 1.04171442093217 0.000272475544954865 -1.28292278880275 0.00693377483778813 mirMAP -0.291724848284574 0.0138106859322311 NA NA NA hsa-miR-708-3p IRAK3 0.623782703831307 0.275355868302311 -1.28292278880275 0.00693377483778813 mirMAP -0.174467830506568 0.00329971006032172 NA NA NA hsa-miR-9-3p IRAK3 0.330346058941473 0.541111939982661 -1.28292278880275 0.00693377483778813 mirMAP -0.236303779612564 0.000292753822407025 NA NA NA hsa-miR-92a-3p IRAK3 1.2209325870225 6.8757197708107e-06 -1.28292278880275 0.00693377483778813 mirMAP -0.544355040380052 7.82819003811389e-06 NA NA NA hsa-miR-92b-3p IRAK3 1.33518446513417 1.45350885391576e-06 -1.28292278880275 0.00693377483778813 mirMAP -0.296495694049502 0.0141967061638133 NA NA NA hsa-miR-944 IRAK3 3.33123095809751 0.0177835044930391 -1.28292278880275 0.00693377483778813 mirMAP -0.159410366044099 8.27508903217135e-09 NA NA NA hsa-miR-16-2-3p IRAK4 1.8048179609245 2.83095715136409e-09 -0.464919789184711 0.00231754450519384 mirMAP -0.109660736850925 0.00139428143173774 NA NA NA hsa-miR-320a IRAK4 0.593888711838028 0.011897419390526 -0.464919789184711 0.00231754450519384 miRanda -0.111617548169913 0.0162918464207639 NA NA NA hsa-miR-320b IRAK4 1.11183660885284 0.000497971211648503 -0.464919789184711 0.00231754450519384 miRanda -0.111853523804352 0.000853309263704889 NA NA NA hsa-miR-421 IRAK4 1.80720854070385 1.59709651202848e-07 -0.464919789184711 0.00231754450519384 miRanda -0.104423408894593 0.000588902634194444 NA NA NA hsa-miR-17-3p MAP3K14 1.31126744284937 3.24768335024185e-07 -0.259250519497319 0.26795775361 MirTarget -0.190284157688133 0.00260851214537523 NA NA NA hsa-miR-17-5p MAP3K14 1.65862087862483 8.45603406215941e-08 -0.259250519497319 0.26795775361 MirTarget -0.141133091627603 0.00671504081676105 NA NA NA hsa-miR-185-3p MAP3K14 1.33711019171256 3.45756583967985e-05 -0.259250519497319 0.26795775361 MirTarget -0.248869688925321 4.8658984259307e-07 NA NA NA hsa-miR-20a-5p MAP3K14 1.4503375861709 5.7813456424762e-07 -0.259250519497319 0.26795775361 MirTarget -0.113613712391103 0.0430128282345905 NA NA NA hsa-miR-331-3p MAP3K14 1.04880525429426 9.99995355989124e-05 -0.259250519497319 0.26795775361 MirTarget -0.153260498079271 0.0122129825209264 NA NA NA hsa-miR-345-5p MAP3K14 1.83686164833727 1.1036889735857e-08 -0.259250519497319 0.26795775361 MirTarget -0.131943070340609 0.00816023179144145 NA NA NA hsa-miR-34c-5p MAP3K14 2.20632574870337 0.000379662996168678 -0.259250519497319 0.26795775361 MirTarget -0.0942493395318452 0.000336351212805599 NA NA NA hsa-miR-429 MAP3K14 1.40182602301928 0.00900426780286475 -0.259250519497319 0.26795775361 miRNATAP -0.101734240054609 0.000846699347081948 NA NA NA hsa-miR-542-3p MAP3K14 0.757649022262991 0.00210575463285599 -0.259250519497319 0.26795775361 miRanda -0.191756297239305 0.00447914443598292 27107696 miR 542 3p suppresses invasion and metastasis by targeting the proto oncogene serine/threonine protein kinase PIM1 in melanoma; The proto-oncogene serine/threonine protein kinase PIM1 was identified as a direct target of miR-542-3p using luciferase reporter assay qRT-PCR and western blot analyses metastasis melanoma hsa-miR-29b-2-5p MYD88 -1.7015307882027 2.84239251703401e-10 0.54749642729313 0.0107730270296967 MirTarget -0.142082363879052 0.00927935909323925 NA NA NA hsa-miR-365a-3p MYD88 -0.891537000455889 0.0025537650440002 0.54749642729313 0.0107730270296967 MirTarget -0.197752525582106 0.000111325434456547 NA NA NA hsa-miR-129-5p NFKB1 -2.56914016541176 2.36237896095709e-06 0.152736736926761 0.349242366061342 PITA;miRanda -0.0623866336691349 0.00277899962567428 NA NA NA hsa-miR-9-5p NFKB1 -0.195328736653048 0.761470692992178 0.152736736926761 0.349242366061342 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0526887066315918 0.00307743368064979 NA NA NA hsa-miR-3065-5p NFKBIA -0.241623656423063 0.633116553078159 0.315554814210481 0.271073728411717 MirTarget -0.112423562227453 0.00640620267431026 NA NA NA hsa-miR-335-5p NFKBIA 1.59953351087307 5.56170899867314e-05 0.315554814210481 0.271073728411717 miRNAWalker2_validate -0.112728597801397 0.0258062332919496 NA NA NA hsa-let-7f-5p NGF 0.634633924115866 0.0344982923411787 -0.0044354260251589 0.994557609636983 MirTarget -0.455658818520987 0.00313618077968416 NA NA NA hsa-let-7g-5p NGF 0.325297685027927 0.241142963826631 -0.0044354260251589 0.994557609636983 MirTarget -0.833551967281976 3.8902528304102e-07 NA NA NA hsa-miR-423-5p NGF 0.832613878736338 0.000791321227103338 -0.0044354260251589 0.994557609636983 MirTarget;miRNATAP -0.706016056377721 0.0001322029752225 NA NA NA hsa-miR-429 NGF 1.40182602301928 0.00900426780286475 -0.0044354260251589 0.994557609636983 miRanda -0.396695496445767 2.17739891550587e-06 NA NA NA hsa-let-7f-1-3p PIK3CA 1.28704406797397 1.17954701106157e-06 0.181162005416898 0.379919524282219 mirMAP -0.113268138136137 0.0370848851494117 NA NA NA hsa-miR-126-5p PIK3CA 0.41765430251855 0.0753161203651532 0.181162005416898 0.379919524282219 mirMAP -0.230165325454576 0.000229328041159233 NA NA NA hsa-miR-142-5p PIK3CA 1.55592486377018 6.69269968016779e-06 0.181162005416898 0.379919524282219 mirMAP -0.08977760823318 0.0306407684304923 NA NA NA hsa-miR-146a-5p PIK3CA 1.82051649415508 2.03651725047679e-05 0.181162005416898 0.379919524282219 mirMAP -0.130514283326015 8.03472410512393e-05 NA NA NA hsa-miR-148a-5p PIK3CA -0.69329616490858 0.0793012233740369 0.181162005416898 0.379919524282219 mirMAP -0.160710142606256 9.74691916818117e-06 NA NA NA hsa-miR-148b-3p PIK3CA 0.295175884456199 0.17466422420702 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.270665697414514 6.25461929338548e-05 NA NA NA hsa-miR-186-5p PIK3CA 0.149964130725901 0.434709542998771 0.181162005416898 0.379919524282219 mirMAP -0.283664174467296 0.000254482000083255 NA NA NA hsa-miR-200b-3p PIK3CA 0.974577911407732 0.0595020056914543 0.181162005416898 0.379919524282219 TargetScan -0.0884531204504068 0.00158217801671178 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.606560155953522 0.116355599574769 0.181162005416898 0.379919524282219 mirMAP -0.105962073023743 0.00514891759991948 NA NA NA hsa-miR-32-3p PIK3CA 0.583525764322974 0.11837203008551 0.181162005416898 0.379919524282219 mirMAP -0.0924036675398858 0.0365447317501377 NA NA NA hsa-miR-320b PIK3CA 1.11183660885284 0.000497971211648503 0.181162005416898 0.379919524282219 miRanda -0.131928082159166 0.00355606170878243 NA NA NA hsa-miR-320c PIK3CA 0.455072851945474 0.240613785444485 0.181162005416898 0.379919524282219 miRanda -0.0956975579730984 0.0290567361862382 NA NA NA hsa-miR-335-3p PIK3CA 2.5197689063267 2.20084506976733e-09 0.181162005416898 0.379919524282219 mirMAP -0.0916831776367731 0.00572624788207425 NA NA NA hsa-miR-335-5p PIK3CA 1.59953351087307 5.56170899867314e-05 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.142668444274705 6.55217134166698e-05 NA NA NA hsa-miR-338-5p PIK3CA -1.19659203838734 0.0100316010080496 0.181162005416898 0.379919524282219 mirMAP -0.128160056012068 3.12181075963217e-05 NA NA NA hsa-miR-361-5p PIK3CA 0.407725414130987 0.0181260969156347 0.181162005416898 0.379919524282219 mirMAP -0.195169509581991 0.0254445746067009 NA NA NA hsa-miR-501-5p PIK3CA 0.266919328110625 0.454779001968586 0.181162005416898 0.379919524282219 mirMAP -0.184484665922465 4.78508048904086e-06 NA NA NA hsa-miR-577 PIK3CA 0.911619788986754 0.2256062124148 0.181162005416898 0.379919524282219 mirMAP -0.0930447872986698 1.63984112659925e-06 NA NA NA hsa-miR-590-3p PIK3CA 1.11654983899947 0.000160782154924864 0.181162005416898 0.379919524282219 miRanda;mirMAP -0.0966121410197607 0.0490914187131799 NA NA NA hsa-miR-7-1-3p PIK3CA 0.709309110750947 0.0412301737463194 0.181162005416898 0.379919524282219 mirMAP -0.18347710340594 9.07765701687707e-06 NA NA NA hsa-miR-130a-3p PIK3CB 0.146223920674657 0.633739795905839 0.248944033508746 0.180378115579181 miRNATAP -0.141347568269357 0.0010035949231668 NA NA NA hsa-miR-199b-3p PIK3CB 0.860968252593043 0.00032297319521262 0.248944033508746 0.180378115579181 miRNATAP -0.127976776537123 0.0199762343481395 NA NA NA hsa-miR-214-3p PIK3CB 1.01201534142544 0.00625092909225755 0.248944033508746 0.180378115579181 miRNATAP -0.0777380047619174 0.0282370866713523 NA NA NA hsa-miR-1468-5p PIK3CD -1.88350218312373 3.31332405201189e-05 0.391814669139483 0.253077445924908 MirTarget -0.217696918010317 3.06934786857079e-05 NA NA NA hsa-miR-29b-3p PIK3CD -0.230693226193598 0.367461626035234 0.391814669139483 0.253077445924908 mirMAP -0.217563648605112 0.024520844478758 NA NA NA hsa-miR-30b-3p PIK3CD -0.266398938200332 0.400847813143994 0.391814669139483 0.253077445924908 MirTarget -0.431008741394064 8.57729594514163e-09 NA NA NA hsa-miR-30b-5p PIK3CD -0.430720743745757 0.0593564057320791 0.391814669139483 0.253077445924908 MirTarget -0.481822586915696 5.93876910377637e-06 NA NA NA hsa-miR-30d-5p PIK3CD -0.5492586056147 0.0140125082460125 0.391814669139483 0.253077445924908 MirTarget;miRNATAP -0.669349357920634 2.53796175626459e-10 NA NA NA hsa-miR-616-5p PIK3CD 0.834052908652744 0.0347835664029363 0.391814669139483 0.253077445924908 MirTarget -0.171408745877689 0.0062816347712319 NA NA NA hsa-miR-7-5p PIK3CD 1.63575693499363 0.0124424214624534 0.391814669139483 0.253077445924908 miRTarBase;MirTarget;miRNATAP -0.205801781586893 4.40558507915807e-08 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-103a-3p PIK3R1 0.840525139266028 5.83536475789158e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.323457232113071 0.0039447769693221 NA NA NA hsa-miR-106b-5p PIK3R1 1.70863907461894 2.04074794107142e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.253346436583178 1.72729352701852e-05 NA NA NA hsa-miR-107 PIK3R1 0.904627575346218 4.67936495073904e-05 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.238654922729134 0.0046938788179217 NA NA NA hsa-miR-128-3p PIK3R1 0.98280381420517 5.77641850797209e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.253825409257793 0.000861541031670611 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-144-3p PIK3R1 -0.13309578176575 0.798245647923351 -1.09428616452248 2.46783518047221e-05 mirMAP -0.138673461850839 0.000126186382128809 NA NA NA hsa-miR-144-5p PIK3R1 -0.644861505244731 0.173474442191587 -1.09428616452248 2.46783518047221e-05 mirMAP -0.0984710359280616 0.0131250792902361 NA NA NA hsa-miR-15b-5p PIK3R1 1.62046407540723 5.42152621571078e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.323211150072369 4.46298725379362e-07 NA NA NA hsa-miR-16-2-3p PIK3R1 1.8048179609245 2.83095715136409e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.270383492169966 3.99207467881518e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.00515772948091 5.33912942007619e-06 -1.09428616452248 2.46783518047221e-05 MirTarget -0.405416526556489 9.69480909855754e-07 NA NA NA hsa-miR-17-5p PIK3R1 1.65862087862483 8.45603406215941e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;TargetScan;miRNATAP -0.192199170444737 0.00107429271534319 NA NA NA hsa-miR-182-5p PIK3R1 0.887369486030646 0.0310640781418789 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.160218491940506 0.000398426335382569 NA NA NA hsa-miR-185-5p PIK3R1 1.14351510556643 1.07346945085714e-08 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.41775889137189 4.21636400438791e-06 NA NA NA hsa-miR-188-5p PIK3R1 1.35426907033843 0.00038346077691455 -1.09428616452248 2.46783518047221e-05 MirTarget -0.162900447887926 0.000775923703794411 NA NA NA hsa-miR-200b-3p PIK3R1 0.974577911407732 0.0595020056914543 -1.09428616452248 2.46783518047221e-05 mirMAP -0.103803538669649 0.00409847558383849 NA NA NA hsa-miR-200c-3p PIK3R1 1.28185685499076 0.00369777635539177 -1.09428616452248 2.46783518047221e-05 mirMAP -0.143316221972735 0.00063899158230993 NA NA NA hsa-miR-20a-5p PIK3R1 1.4503375861709 5.7813456424762e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.175478538743826 0.0056099063555159 NA NA NA hsa-miR-21-5p PIK3R1 1.75445050487988 2.41825549682022e-23 -1.09428616452248 2.46783518047221e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.306402457018565 0.00154965993784699 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.960352937108106 0.00133449812322732 -1.09428616452248 2.46783518047221e-05 MirTarget -0.22956448368642 0.000224776230276284 NA NA NA hsa-miR-22-5p PIK3R1 0.804348748654247 0.000804065112767412 -1.09428616452248 2.46783518047221e-05 mirMAP -0.271562984507077 0.000499671844853285 NA NA NA hsa-miR-221-3p PIK3R1 1.33496247538338 3.82022531235275e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.313499877783358 5.35467630228685e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.39382731585819 9.98182478024671e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.284754511073413 7.61572703183408e-06 NA NA NA hsa-miR-224-3p PIK3R1 1.52422171450716 0.00650463542340912 -1.09428616452248 2.46783518047221e-05 mirMAP -0.0832920972974807 0.022720247689055 NA NA NA hsa-miR-3065-5p PIK3R1 -0.241623656423063 0.633116553078159 -1.09428616452248 2.46783518047221e-05 MirTarget;mirMAP;miRNATAP -0.124182539774803 0.00105993614946939 NA NA NA hsa-miR-32-3p PIK3R1 0.583525764322974 0.11837203008551 -1.09428616452248 2.46783518047221e-05 mirMAP -0.17265888879632 0.00228085828010069 NA NA NA hsa-miR-320b PIK3R1 1.11183660885284 0.000497971211648503 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.162259703959997 0.00544641812773208 NA NA NA hsa-miR-324-3p PIK3R1 1.04940352369965 0.000387716796520961 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.184232658949902 0.00347746569584922 NA NA NA hsa-miR-330-3p PIK3R1 0.798460296022179 0.00746538156533435 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.26440540068663 2.08637052595379e-05 NA NA NA hsa-miR-335-3p PIK3R1 2.5197689063267 2.20084506976733e-09 -1.09428616452248 2.46783518047221e-05 mirMAP -0.148076206465714 0.000495756694433814 NA NA NA hsa-miR-424-5p PIK3R1 1.08509868581983 0.000420473853818268 -1.09428616452248 2.46783518047221e-05 MirTarget -0.287369315123124 1.32105570633977e-06 NA NA NA hsa-miR-429 PIK3R1 1.40182602301928 0.00900426780286475 -1.09428616452248 2.46783518047221e-05 mirMAP;miRNATAP -0.126994249956039 0.00022771493817442 NA NA NA hsa-miR-455-3p PIK3R1 2.29532323519288 1.85675588946527e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.181586331748295 8.05157474846207e-06 NA NA NA hsa-miR-532-3p PIK3R1 0.552364451472481 0.0975490365586023 -1.09428616452248 2.46783518047221e-05 MirTarget -0.139383646263582 0.0139026311190609 NA NA NA hsa-miR-542-3p PIK3R1 0.757649022262991 0.00210575463285599 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda -0.239065351988831 0.0017318237826115 NA NA NA hsa-miR-584-5p PIK3R1 1.68234626630933 0.000166828539264215 -1.09428616452248 2.46783518047221e-05 mirMAP -0.129450210806705 0.00170622715972499 NA NA NA hsa-miR-590-3p PIK3R1 1.11654983899947 0.000160782154924864 -1.09428616452248 2.46783518047221e-05 miRanda;mirMAP -0.266046553887174 1.8351581859886e-05 NA NA NA hsa-miR-590-5p PIK3R1 1.04171442093217 0.000272475544954865 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.297910761408884 3.33366270664506e-06 NA NA NA hsa-miR-629-3p PIK3R1 1.40326397107309 9.7803063526732e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.16619442916244 0.00118253063445621 NA NA NA hsa-miR-93-5p PIK3R1 1.7515174434778 1.59386482413883e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.142060800566976 0.0157552165323649 NA NA NA hsa-miR-96-5p PIK3R1 1.14243043653372 0.00942969392739105 -1.09428616452248 2.46783518047221e-05 TargetScan;miRNATAP -0.193630203103858 1.00718533638407e-05 NA NA NA hsa-miR-30a-5p PIK3R2 -1.71922855140016 3.20574349285256e-07 0.00922907299312037 0.961081205853821 miRNATAP -0.137164224996737 0.000346855164996688 NA NA NA hsa-miR-30c-5p PIK3R2 -0.983130268805942 4.60419218706127e-05 0.00922907299312037 0.961081205853821 miRNAWalker2_validate;miRNATAP -0.109935407847297 0.0466412404522513 NA NA NA hsa-miR-34a-5p PIK3R2 0.794251341270032 0.00024017386701179 0.00922907299312037 0.961081205853821 MirTarget -0.140710131219621 0.0234788229165243 NA NA NA hsa-miR-1271-5p PIK3R3 1.15538250415776 0.00207865862606828 -0.662491536689023 0.0210304127874503 mirMAP -0.197799197361284 0.00028487328401707 NA NA NA hsa-miR-15b-3p PIK3R3 1.75738933306437 3.00554466232543e-08 -0.662491536689023 0.0210304127874503 mirMAP -0.135125079713348 0.0315067087632781 NA NA NA hsa-miR-185-3p PIK3R3 1.33711019171256 3.45756583967985e-05 -0.662491536689023 0.0210304127874503 MirTarget -0.200301326896551 0.00130353125166929 NA NA NA hsa-miR-3065-5p PIK3R3 -0.241623656423063 0.633116553078159 -0.662491536689023 0.0210304127874503 mirMAP;miRNATAP -0.0889787673700246 0.0327334877557375 NA NA NA hsa-miR-365a-3p PIK3R3 -0.891537000455889 0.0025537650440002 -0.662491536689023 0.0210304127874503 MirTarget -0.156661764888904 0.023970209352624 NA NA NA hsa-miR-381-3p PIK3R3 -0.385137659444633 0.19550293487428 -0.662491536689023 0.0210304127874503 mirMAP -0.141086462479112 0.0428502137074298 NA NA NA hsa-miR-382-5p PIK3R3 0.592305208032135 0.0451384362870204 -0.662491536689023 0.0210304127874503 mirMAP -0.153099118159323 0.0283764546327731 NA NA NA hsa-miR-511-5p PIK3R3 0.542335183701817 0.127507740178883 -0.662491536689023 0.0210304127874503 MirTarget -0.231823970894027 4.82261601939889e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-590-5p PIK3R3 1.04171442093217 0.000272475544954865 -0.662491536689023 0.0210304127874503 miRanda -0.144175077066519 0.0435596859257967 NA NA NA hsa-miR-624-5p PIK3R3 1.03467956701702 0.0010908013402586 -0.662491536689023 0.0210304127874503 MirTarget -0.149044156133211 0.0290648229440743 NA NA NA hsa-miR-708-3p PIK3R3 0.623782703831307 0.275355868302311 -0.662491536689023 0.0210304127874503 mirMAP -0.147502347303041 2.93933869168246e-05 NA NA NA hsa-miR-96-5p PIK3R3 1.14243043653372 0.00942969392739105 -0.662491536689023 0.0210304127874503 mirMAP -0.108040730164296 0.0265175074189413 NA NA NA hsa-miR-182-5p PIK3R5 0.887369486030646 0.0310640781418789 -0.106061319644644 0.802628610118832 MirTarget -0.363007599134275 3.56264538888151e-07 NA NA NA hsa-miR-18a-3p PIK3R5 2.35188582849667 1.39401350286321e-08 -0.106061319644644 0.802628610118832 MirTarget -0.215221108190999 0.00210782353217643 NA NA NA hsa-miR-615-3p PIK3R5 2.82967143704683 3.05118423223543e-05 -0.106061319644644 0.802628610118832 miRanda -0.148113867472387 0.0143777912224027 NA NA NA hsa-miR-944 PIK3R5 3.33123095809751 0.0177835044930391 -0.106061319644644 0.802628610118832 mirMAP -0.0679738896124535 0.00719808669918552 NA NA NA hsa-miR-106b-5p PPP3CA 1.70863907461894 2.04074794107142e-08 -0.311261735064956 0.0874904847441977 miRNATAP -0.177382254092271 1.11662949783484e-05 NA NA NA hsa-miR-142-5p PPP3CA 1.55592486377018 6.69269968016779e-06 -0.311261735064956 0.0874904847441977 PITA;mirMAP;miRNATAP -0.110997481793963 0.00234330425678312 NA NA NA hsa-miR-186-5p PPP3CA 0.149964130725901 0.434709542998771 -0.311261735064956 0.0874904847441977 mirMAP -0.163203955359163 0.0183775975703549 NA NA NA hsa-miR-320a PPP3CA 0.593888711838028 0.011897419390526 -0.311261735064956 0.0874904847441977 miRanda -0.133814421674492 0.0153403009940942 NA NA NA hsa-miR-320b PPP3CA 1.11183660885284 0.000497971211648503 -0.311261735064956 0.0874904847441977 miRanda -0.0902581261028706 0.0246297260348028 NA NA NA hsa-miR-335-3p PPP3CA 2.5197689063267 2.20084506976733e-09 -0.311261735064956 0.0874904847441977 MirTarget -0.0873420390105666 0.00284466125758765 NA NA NA hsa-miR-340-5p PPP3CA -0.164941927483643 0.529910509321278 -0.311261735064956 0.0874904847441977 mirMAP -0.181573032833897 0.000232248398119678 NA NA NA hsa-miR-361-5p PPP3CA 0.407725414130987 0.0181260969156347 -0.311261735064956 0.0874904847441977 miRanda -0.225189217128007 0.0033708826866865 NA NA NA hsa-miR-374b-3p PPP3CA 0.999491658196932 0.00126937019814872 -0.311261735064956 0.0874904847441977 MirTarget -0.164661177292416 0.000153667800685453 NA NA NA hsa-miR-501-3p PPP3CA 0.731876211669996 0.0270421347018303 -0.311261735064956 0.0874904847441977 MirTarget;PITA;miRNATAP -0.0876298348148308 0.0249289170368034 NA NA NA hsa-miR-502-3p PPP3CA -0.16442685491191 0.557471818466728 -0.311261735064956 0.0874904847441977 MirTarget;PITA;miRNATAP -0.0935506674575698 0.0450720778175197 NA NA NA hsa-miR-589-3p PPP3CA 1.01962606923682 0.00577853347252709 -0.311261735064956 0.0874904847441977 MirTarget -0.0708174358558804 0.042209420161778 NA NA NA hsa-miR-590-5p PPP3CA 1.04171442093217 0.000272475544954865 -0.311261735064956 0.0874904847441977 PITA;miRanda;miRNATAP -0.120747875637189 0.00696948367873323 NA NA NA hsa-miR-93-3p PPP3CA 1.88964231421793 1.80075645722786e-08 -0.311261735064956 0.0874904847441977 miRNATAP -0.0819860006758133 0.0277256543346093 NA NA NA hsa-miR-93-5p PPP3CA 1.7515174434778 1.59386482413883e-08 -0.311261735064956 0.0874904847441977 miRNATAP -0.0803533671989684 0.0469113204103882 NA NA NA hsa-miR-940 PPP3CA 1.64406174271686 0.000690854900107004 -0.311261735064956 0.0874904847441977 miRNATAP -0.111531019863646 0.000298626343209584 NA NA NA hsa-miR-107 PPP3CB 0.904627575346218 4.67936495073904e-05 -0.544004942139345 9.04819078192179e-05 miRanda -0.142015238506317 0.00140035242278882 NA NA NA hsa-miR-15a-5p PPP3CB 1.03783090449383 7.40334108980898e-07 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.163057694878539 0.000473345260508312 NA NA NA hsa-miR-15b-5p PPP3CB 1.62046407540723 5.42152621571078e-09 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.186954475055184 2.5872809097186e-08 NA NA NA hsa-miR-16-5p PPP3CB 1.00515772948091 5.33912942007619e-06 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.20524854257795 2.83538301027824e-06 NA NA NA hsa-miR-20a-3p PPP3CB 1.13957127410163 0.000451087640268489 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.125773580763174 2.60598588386373e-05 NA NA NA hsa-miR-30d-5p PPP3CB -0.5492586056147 0.0140125082460125 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.108158227563065 0.0163524224545141 NA NA NA hsa-miR-320c PPP3CB 0.455072851945474 0.240613785444485 -0.544004942139345 9.04819078192179e-05 miRanda -0.0644545718488562 0.0307987629307516 NA NA NA hsa-miR-339-5p PPP3CB 0.770566566962108 0.00816529093411862 -0.544004942139345 9.04819078192179e-05 miRanda -0.140550747992229 3.00402583828723e-05 NA NA NA hsa-miR-421 PPP3CB 1.80720854070385 1.59709651202848e-07 -0.544004942139345 9.04819078192179e-05 miRanda -0.0871538548751366 0.00177477956867327 NA NA NA hsa-miR-424-5p PPP3CB 1.08509868581983 0.000420473853818268 -0.544004942139345 9.04819078192179e-05 miRNATAP -0.0931099422712368 0.00360401630746375 NA NA NA hsa-miR-429 PPP3CB 1.40182602301928 0.00900426780286475 -0.544004942139345 9.04819078192179e-05 miRanda -0.0908103705811926 4.01299529730675e-07 NA NA NA hsa-miR-450b-5p PPP3CB 0.46157963033014 0.13273722727895 -0.544004942139345 9.04819078192179e-05 MirTarget;PITA;miRNATAP -0.0698995179834023 0.0322430657227588 NA NA NA hsa-miR-452-5p PPP3CB 2.08756506185889 0.000258095769002813 -0.544004942139345 9.04819078192179e-05 MirTarget;miRNATAP -0.0567044194299448 0.000851136771606869 NA NA NA hsa-miR-501-5p PPP3CB 0.266919328110625 0.454779001968586 -0.544004942139345 9.04819078192179e-05 PITA;miRNATAP -0.0805137636190342 0.00390288059120044 NA NA NA hsa-miR-577 PPP3CB 0.911619788986754 0.2256062124148 -0.544004942139345 9.04819078192179e-05 mirMAP -0.0507565930119968 0.000144625567056098 NA NA NA hsa-miR-590-3p PPP3CB 1.11654983899947 0.000160782154924864 -0.544004942139345 9.04819078192179e-05 miRanda -0.0984671949285603 0.00302216298108695 NA NA NA hsa-miR-7-1-3p PPP3CB 0.709309110750947 0.0412301737463194 -0.544004942139345 9.04819078192179e-05 mirMAP -0.112769612670814 6.65442420729316e-05 NA NA NA hsa-miR-101-3p PPP3R1 -0.451263906815861 0.0283387250173031 0.365031614184003 0.00208633293716482 miRNATAP -0.129816071813413 0.00164042594155264 NA NA NA hsa-miR-139-5p PPP3R1 -1.83374360776637 1.22019901002824e-09 0.365031614184003 0.00208633293716482 miRanda -0.0547519645918423 0.0409382192301088 NA NA NA hsa-miR-26a-5p PPP3R1 -0.384110714440647 0.0442498636014044 0.365031614184003 0.00208633293716482 MirTarget;miRNATAP -0.142127049894375 0.00146987441972325 NA NA NA hsa-miR-340-5p PPP3R1 -0.164941927483643 0.529910509321278 0.365031614184003 0.00208633293716482 mirMAP -0.0654987418767766 0.0431481489715599 NA NA NA hsa-miR-2110 PRKACA 0.759864042760204 0.0723961390557655 -0.0978746557285595 0.44498806360937 MirTarget -0.0798712196795772 0.000170415193867024 NA NA NA hsa-miR-30b-3p PRKACA -0.266398938200332 0.400847813143994 -0.0978746557285595 0.44498806360937 MirTarget -0.0582561127920466 0.0413296864496745 NA NA NA hsa-miR-532-3p PRKACA 0.552364451472481 0.0975490365586023 -0.0978746557285595 0.44498806360937 miRNATAP -0.0626533841741674 0.0203832417378236 NA NA NA hsa-miR-590-3p PRKACA 1.11654983899947 0.000160782154924864 -0.0978746557285595 0.44498806360937 miRanda -0.0598654344545916 0.0469644830357157 NA NA NA hsa-miR-625-5p PRKACA 0.537211086526376 0.203801009380384 -0.0978746557285595 0.44498806360937 MirTarget -0.131652673177358 1.09755795457608e-10 NA NA NA hsa-let-7f-1-3p PRKACB 1.28704406797397 1.17954701106157e-06 -2.00320334289066 3.9598668244402e-09 MirTarget;mirMAP -0.314793266126612 0.000724594726922014 NA NA NA hsa-miR-141-3p PRKACB 1.45548825076434 0.00115958850961764 -2.00320334289066 3.9598668244402e-09 MirTarget;TargetScan;miRNATAP -0.197564834301336 0.000353082319368401 NA NA NA hsa-miR-146b-5p PRKACB 1.547491371264 6.06614361290688e-08 -2.00320334289066 3.9598668244402e-09 miRanda -0.225282836158709 0.00882894958009726 NA NA NA hsa-miR-16-2-3p PRKACB 1.8048179609245 2.83095715136409e-09 -2.00320334289066 3.9598668244402e-09 mirMAP -0.306924849458949 0.000109522279734088 NA NA NA hsa-miR-17-5p PRKACB 1.65862087862483 8.45603406215941e-08 -2.00320334289066 3.9598668244402e-09 TargetScan -0.352359251315541 6.11316064096321e-06 NA NA NA hsa-miR-182-5p PRKACB 0.887369486030646 0.0310640781418789 -2.00320334289066 3.9598668244402e-09 MirTarget;miRNATAP -0.127541599651616 0.0377327189412737 NA NA NA hsa-miR-183-5p PRKACB 1.65900927871187 0.000522025364980187 -2.00320334289066 3.9598668244402e-09 MirTarget -0.181167666603194 0.000458522643446536 NA NA NA hsa-miR-18a-5p PRKACB 2.20211504140984 1.78678887916334e-09 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.316335887919593 1.04839236101925e-06 NA NA NA hsa-miR-19a-3p PRKACB 1.26669687448473 0.000105972838514412 -2.00320334289066 3.9598668244402e-09 MirTarget;miRNATAP -0.151429477699398 0.0481701583396453 NA NA NA hsa-miR-200c-3p PRKACB 1.28185685499076 0.00369777635539177 -2.00320334289066 3.9598668244402e-09 MirTarget;miRNATAP -0.207576946884606 0.000221208096678535 NA NA NA hsa-miR-2110 PRKACB 0.759864042760204 0.0723961390557655 -2.00320334289066 3.9598668244402e-09 MirTarget -0.183383468055812 0.00233810067736044 NA NA NA hsa-miR-32-3p PRKACB 0.583525764322974 0.11837203008551 -2.00320334289066 3.9598668244402e-09 mirMAP;miRNATAP -0.182625258960846 0.0167162629285263 NA NA NA hsa-miR-330-3p PRKACB 0.798460296022179 0.00746538156533435 -2.00320334289066 3.9598668244402e-09 MirTarget -0.302274508758057 0.000317953568855911 NA NA NA hsa-miR-34a-5p PRKACB 0.794251341270032 0.00024017386701179 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.256547510181458 0.0290649337116807 NA NA NA hsa-miR-361-5p PRKACB 0.407725414130987 0.0181260969156347 -2.00320334289066 3.9598668244402e-09 miRanda -0.504068079086418 0.000769646776305189 NA NA NA hsa-miR-3662 PRKACB 1.82780708047676 0.0054036501346178 -2.00320334289066 3.9598668244402e-09 MirTarget;mirMAP -0.112987389006657 0.0222082267490311 NA NA NA hsa-miR-421 PRKACB 1.80720854070385 1.59709651202848e-07 -2.00320334289066 3.9598668244402e-09 PITA;miRanda -0.335137675315492 1.50625671113954e-06 NA NA NA hsa-miR-429 PRKACB 1.40182602301928 0.00900426780286475 -2.00320334289066 3.9598668244402e-09 MirTarget;PITA;miRanda;miRNATAP -0.101627495493247 0.0298222532386212 NA NA NA hsa-miR-532-5p PRKACB 0.313080805824184 0.252248939356301 -2.00320334289066 3.9598668244402e-09 PITA -0.223656047569022 0.0166813357795424 NA NA NA hsa-miR-577 PRKACB 0.911619788986754 0.2256062124148 -2.00320334289066 3.9598668244402e-09 PITA -0.077402580234511 0.0242782967558829 NA NA NA hsa-miR-590-5p PRKACB 1.04171442093217 0.000272475544954865 -2.00320334289066 3.9598668244402e-09 miRanda -0.271769978727668 0.00186178178431082 NA NA NA hsa-miR-616-5p PRKACB 0.834052908652744 0.0347835664029363 -2.00320334289066 3.9598668244402e-09 mirMAP -0.131896880665198 0.0432377262875567 NA NA NA hsa-miR-93-5p PRKACB 1.7515174434778 1.59386482413883e-08 -2.00320334289066 3.9598668244402e-09 miRNAWalker2_validate -0.293844505175028 0.000169582064126035 NA NA NA hsa-miR-96-5p PRKACB 1.14243043653372 0.00942969392739105 -2.00320334289066 3.9598668244402e-09 miRNATAP -0.170553493993393 0.00429769927359632 NA NA NA hsa-miR-107 PRKAR1A 0.904627575346218 4.67936495073904e-05 -0.261184869472083 0.054030676709783 miRanda -0.207698852168786 7.16194344210351e-07 NA NA NA hsa-miR-1296-5p PRKAR1A 1.24127275671822 0.000834150627135999 -0.261184869472083 0.054030676709783 miRNAWalker2_validate -0.0820991711261675 0.00117854952551448 NA NA NA hsa-miR-16-2-3p PRKAR1A 1.8048179609245 2.83095715136409e-09 -0.261184869472083 0.054030676709783 mirMAP -0.075295856987879 0.0129826673991346 NA NA NA hsa-miR-16-5p PRKAR1A 1.00515772948091 5.33912942007619e-06 -0.261184869472083 0.054030676709783 miRNAWalker2_validate -0.115179013016791 0.00723464540139017 NA NA NA hsa-miR-182-5p PRKAR1A 0.887369486030646 0.0310640781418789 -0.261184869472083 0.054030676709783 miRNATAP -0.0618877509281712 0.00738267170789522 NA NA NA hsa-miR-186-5p PRKAR1A 0.149964130725901 0.434709542998771 -0.261184869472083 0.054030676709783 mirMAP -0.194228181056638 0.000123242397936607 NA NA NA hsa-miR-200b-3p PRKAR1A 0.974577911407732 0.0595020056914543 -0.261184869472083 0.054030676709783 TargetScan -0.0564480833633155 0.00204537286214967 NA NA NA hsa-miR-25-3p PRKAR1A 1.00604871526544 0.000421838061147906 -0.261184869472083 0.054030676709783 miRNAWalker2_validate -0.0853769470266296 0.0102610050382696 NA NA NA hsa-miR-30b-5p PRKAR1A -0.430720743745757 0.0593564057320791 -0.261184869472083 0.054030676709783 mirMAP -0.0865362247996851 0.0417744081647431 NA NA NA hsa-miR-32-3p PRKAR1A 0.583525764322974 0.11837203008551 -0.261184869472083 0.054030676709783 mirMAP -0.0883695686683699 0.00206724651602713 NA NA NA hsa-miR-320b PRKAR1A 1.11183660885284 0.000497971211648503 -0.261184869472083 0.054030676709783 miRanda -0.0896643178339767 0.00240648676883011 NA NA NA hsa-miR-320c PRKAR1A 0.455072851945474 0.240613785444485 -0.261184869472083 0.054030676709783 miRanda -0.062124799470236 0.0301303450577039 NA NA NA hsa-miR-324-3p PRKAR1A 1.04940352369965 0.000387716796520961 -0.261184869472083 0.054030676709783 miRNAWalker2_validate -0.0837520726182475 0.00894817509268146 NA NA NA hsa-miR-429 PRKAR1A 1.40182602301928 0.00900426780286475 -0.261184869472083 0.054030676709783 PITA;miRanda;miRNATAP -0.0696380227730664 6.36917526932051e-05 NA NA NA hsa-miR-483-3p PRKAR1A 1.09937307882201 0.104408487470684 -0.261184869472083 0.054030676709783 miRNATAP -0.0762758291561657 2.36838413599328e-05 NA NA NA hsa-miR-590-3p PRKAR1A 1.11654983899947 0.000160782154924864 -0.261184869472083 0.054030676709783 miRanda;mirMAP -0.101445127776819 0.00143270696911459 NA NA NA hsa-miR-590-5p PRKAR1A 1.04171442093217 0.000272475544954865 -0.261184869472083 0.054030676709783 miRanda -0.130718971976049 6.49091634277093e-05 NA NA NA hsa-miR-96-5p PRKAR1A 1.14243043653372 0.00942969392739105 -0.261184869472083 0.054030676709783 miRNAWalker2_validate;TargetScan;miRNATAP -0.0741202674872957 0.000977673254534397 NA NA NA hsa-let-7a-3p PRKAR2A 0.503048155002889 0.0411145454335299 -0.666395730088886 0.00288924292930231 mirMAP -0.171437002730096 0.00904277111739313 NA NA NA hsa-let-7b-5p PRKAR2A 0.0582902155815681 0.781400138984745 -0.666395730088886 0.00288924292930231 miRNAWalker2_validate -0.165814309131178 0.03408004228694 NA NA NA hsa-miR-125a-5p PRKAR2A -0.878090699011564 0.000213630844319685 -0.666395730088886 0.00288924292930231 miRanda -0.163887932727186 0.0152473857671742 NA NA NA hsa-miR-146b-5p PRKAR2A 1.547491371264 6.06614361290688e-08 -0.666395730088886 0.00288924292930231 miRanda -0.240483022224169 7.29411765911574e-06 NA NA NA hsa-miR-155-5p PRKAR2A 1.28707757465885 8.6344688246758e-05 -0.666395730088886 0.00288924292930231 miRNAWalker2_validate -0.134008640508635 0.00539507207316991 NA NA NA hsa-miR-16-5p PRKAR2A 1.00515772948091 5.33912942007619e-06 -0.666395730088886 0.00288924292930231 miRNAWalker2_validate -0.207678908855717 0.003857231053268 NA NA NA hsa-miR-182-5p PRKAR2A 0.887369486030646 0.0310640781418789 -0.666395730088886 0.00288924292930231 mirMAP -0.0836363643761046 0.0315536369539371 NA NA NA hsa-miR-193b-5p PRKAR2A 0.609581100028941 0.13923921336815 -0.666395730088886 0.00288924292930231 mirMAP -0.163479364217959 1.94623324174598e-05 NA NA NA hsa-miR-21-5p PRKAR2A 1.75445050487988 2.41825549682022e-23 -0.666395730088886 0.00288924292930231 mirMAP -0.368520996816281 5.78384748671194e-06 NA NA NA hsa-miR-25-3p PRKAR2A 1.00604871526544 0.000421838061147906 -0.666395730088886 0.00288924292930231 mirMAP -0.12864799623205 0.0214124783914522 NA NA NA hsa-miR-342-5p PRKAR2A 0.692955062695486 0.030998736359949 -0.666395730088886 0.00288924292930231 miRNATAP -0.279955905439209 6.45816341333199e-09 NA NA NA hsa-miR-3607-3p PRKAR2A 0.522750552658156 0.0842510989344654 -0.666395730088886 0.00288924292930231 mirMAP -0.185766423696095 0.000431146684646817 NA NA NA hsa-miR-3913-5p PRKAR2A 0.878857760706319 0.00310224428304055 -0.666395730088886 0.00288924292930231 mirMAP -0.157706887180414 0.00346452240723279 NA NA NA hsa-miR-590-5p PRKAR2A 1.04171442093217 0.000272475544954865 -0.666395730088886 0.00288924292930231 mirMAP -0.120949287712009 0.0299876245532441 NA NA NA hsa-miR-708-3p PRKAR2A 0.623782703831307 0.275355868302311 -0.666395730088886 0.00288924292930231 mirMAP -0.152767847410853 1.65731543794426e-08 NA NA NA hsa-miR-944 PRKAR2A 3.33123095809751 0.0177835044930391 -0.666395730088886 0.00288924292930231 mirMAP -0.0645184031324092 9.0888925991609e-07 NA NA NA hsa-let-7a-3p PRKAR2B 0.503048155002889 0.0411145454335299 -2.31198613740557 1.61040825618149e-06 mirMAP -0.471808257381173 0.00105229078353615 NA NA NA hsa-let-7b-3p PRKAR2B 0.21838629112113 0.296038413622566 -2.31198613740557 1.61040825618149e-06 mirMAP -0.75084135025624 9.81880505110698e-06 NA NA NA hsa-let-7f-1-3p PRKAR2B 1.28704406797397 1.17954701106157e-06 -2.31198613740557 1.61040825618149e-06 mirMAP -0.764528974742934 1.29333946371905e-09 NA NA NA hsa-miR-107 PRKAR2B 0.904627575346218 4.67936495073904e-05 -2.31198613740557 1.61040825618149e-06 miRanda -0.758118622628174 1.0243663351818e-06 NA NA NA hsa-miR-186-5p PRKAR2B 0.149964130725901 0.434709542998771 -2.31198613740557 1.61040825618149e-06 mirMAP -0.478015934878305 0.011497138310369 NA NA NA hsa-miR-200b-3p PRKAR2B 0.974577911407732 0.0595020056914543 -2.31198613740557 1.61040825618149e-06 TargetScan -0.341423530167314 2.56289480842019e-07 NA NA NA hsa-miR-200c-3p PRKAR2B 1.28185685499076 0.00369777635539177 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.465335692985934 1.01730200009054e-09 NA NA NA hsa-miR-3065-5p PRKAR2B -0.241623656423063 0.633116553078159 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.208480402728595 0.0034742658894993 NA NA NA hsa-miR-32-5p PRKAR2B 0.415247682945382 0.106458022460373 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.338825902461257 0.0146457468697964 NA NA NA hsa-miR-335-3p PRKAR2B 2.5197689063267 2.20084506976733e-09 -2.31198613740557 1.61040825618149e-06 mirMAP -0.380221012249217 1.31488396083242e-06 NA NA NA hsa-miR-361-5p PRKAR2B 0.407725414130987 0.0181260969156347 -2.31198613740557 1.61040825618149e-06 miRanda -0.523924389253704 0.0129344956477485 NA NA NA hsa-miR-429 PRKAR2B 1.40182602301928 0.00900426780286475 -2.31198613740557 1.61040825618149e-06 PITA;miRanda;miRNATAP -0.369375352905238 4.36044370799977e-09 NA NA NA hsa-miR-450b-5p PRKAR2B 0.46157963033014 0.13273722727895 -2.31198613740557 1.61040825618149e-06 mirMAP;miRNATAP -0.254212637155436 0.028263471654416 NA NA NA hsa-miR-590-3p PRKAR2B 1.11654983899947 0.000160782154924864 -2.31198613740557 1.61040825618149e-06 miRNAWalker2_validate;miRanda -0.536291339909839 3.80317491329214e-06 NA NA NA hsa-miR-92a-3p PRKAR2B 1.2209325870225 6.8757197708107e-06 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.779891965016439 2.15980932687562e-10 NA NA NA hsa-miR-92b-3p PRKAR2B 1.33518446513417 1.45350885391576e-06 -2.31198613740557 1.61040825618149e-06 miRNATAP -0.447001178066512 0.000312365822832101 NA NA NA hsa-miR-148a-3p PRKX -1.53721533763578 3.55533747293117e-05 0.935407411100726 0.00677599594067682 MirTarget -0.161941037542314 0.0134608053260732 NA NA NA hsa-miR-29a-3p PRKX -0.113012156986374 0.615005009685815 0.935407411100726 0.00677599594067682 mirMAP -0.241791870638624 0.0319146211063365 NA NA NA hsa-miR-29b-3p PRKX -0.230693226193598 0.367461626035234 0.935407411100726 0.00677599594067682 mirMAP -0.295729445077546 0.00247925909788979 NA NA NA hsa-miR-29c-3p PRKX -1.62454036584589 5.38376515586029e-07 0.935407411100726 0.00677599594067682 mirMAP -0.21153018883656 0.00447069863244723 NA NA NA hsa-miR-375 PRKX -2.94506033785642 0.00570147601654791 0.935407411100726 0.00677599594067682 miRNAWalker2_validate;miRanda -0.117495305006097 1.46576878210263e-07 NA NA NA hsa-miR-625-3p PRKX -0.185298294014366 0.626215541224408 0.935407411100726 0.00677599594067682 mirMAP -0.149445986269736 0.0224768521904182 NA NA NA hsa-miR-101-5p RELA -0.567139223563276 0.0306291767849722 0.140295374000207 0.30305268869391 mirMAP -0.114893897809984 0.00171325410868005 NA NA NA hsa-miR-186-5p RELA 0.149964130725901 0.434709542998771 0.140295374000207 0.30305268869391 MirTarget -0.119312787547729 0.0199605709621895 NA NA NA hsa-miR-30e-5p RELA -0.573784818166736 0.0112497802572927 0.140295374000207 0.30305268869391 miRNAWalker2_validate -0.152968732905743 0.000301446483160409 NA NA NA hsa-miR-421 RELA 1.80720854070385 1.59709651202848e-07 0.140295374000207 0.30305268869391 miRanda -0.0536366652828218 0.0470640121243676 NA NA NA hsa-miR-127-3p RIPK1 0.211466568760589 0.46101284760949 -0.402912761716757 0.00711653673365392 miRanda -0.0791205525995166 0.0347778866826503 NA NA NA hsa-miR-129-5p TNFRSF10A -2.56914016541176 2.36237896095709e-06 1.1281325350254 7.06622121173794e-05 miRanda -0.152320428719599 3.6346498987375e-05 NA NA NA hsa-miR-145-5p TNFRSF10A -1.75133578902314 1.54965572197748e-05 1.1281325350254 7.06622121173794e-05 MirTarget -0.149945853805366 0.00246019679293889 NA NA NA hsa-miR-28-5p TNFRSF10B -0.238617853755144 0.167318538669818 0.889172473121278 0.00056650739881632 miRanda -0.227199084926118 0.0416795970109508 NA NA NA hsa-let-7e-5p TNFRSF1A 0.405855894534493 0.196257828016759 0.128981356741185 0.485559860409678 miRNAWalker2_validate -0.0878938296116273 0.0361879725895948 NA NA NA hsa-miR-29b-3p TNFRSF1A -0.230693226193598 0.367461626035234 0.128981356741185 0.485559860409678 MirTarget;miRNATAP -0.110671873474021 0.0327866675947734 NA NA NA hsa-miR-29c-3p TNFRSF1A -1.62454036584589 5.38376515586029e-07 0.128981356741185 0.485559860409678 MirTarget;miRNATAP -0.0775107433638288 0.0494464690536921 NA NA NA hsa-miR-129-5p TNFSF10 -2.56914016541176 2.36237896095709e-06 2.04795111795554 4.27678125264408e-07 miRanda -0.159446744636556 0.0031250454523856 NA NA NA hsa-miR-139-5p TNFSF10 -1.83374360776637 1.22019901002824e-09 2.04795111795554 4.27678125264408e-07 miRanda -0.265030965603103 0.00515179692371939 NA NA NA hsa-miR-217 TNFSF10 -0.0121404731225336 0.980818372851502 2.04795111795554 4.27678125264408e-07 miRanda -0.116592693234844 0.0487079585972283 NA NA NA hsa-miR-361-5p TNFSF10 0.407725414130987 0.0181260969156347 2.04795111795554 4.27678125264408e-07 miRanda -0.424329535260143 0.016966802486599 NA NA NA hsa-miR-362-3p TNFSF10 -0.0349414695893027 0.913780708043777 2.04795111795554 4.27678125264408e-07 miRanda -0.297111694649573 0.00134455834390954 NA NA NA hsa-miR-320a TRADD 0.593888711838028 0.011897419390526 0.142849160995165 0.455488050060669 miRanda -0.17984037721139 0.00179026006697006 NA NA NA hsa-miR-320c TRADD 0.455072851945474 0.240613785444485 0.142849160995165 0.455488050060669 miRanda -0.0954586710488911 0.0186416831982025 NA NA NA hsa-miR-101-3p XIAP -0.451263906815861 0.0283387250173031 0.188695357914383 0.26752656530042 miRNAWalker2_validate -0.164231452524637 0.00565130321818158 NA NA NA hsa-miR-10b-3p XIAP 0.773619331000039 0.0076628900286607 0.188695357914383 0.26752656530042 MirTarget -0.101321765076918 0.014569273604569 NA NA NA hsa-miR-125b-2-3p XIAP -0.236995187284862 0.63161659167442 0.188695357914383 0.26752656530042 mirMAP -0.0637686048195041 0.0088859959787584 NA NA NA hsa-miR-125b-5p XIAP -0.509303501421334 0.133265526313161 0.188695357914383 0.26752656530042 miRNAWalker2_validate -0.0959274196778566 0.00688551698456811 NA NA NA hsa-miR-149-5p XIAP 0.706277554734069 0.296848731347677 0.188695357914383 0.26752656530042 MirTarget -0.0567796959085267 0.00125990271786056 NA NA NA hsa-miR-181a-2-3p XIAP 0.901732254836667 0.000830304681396734 0.188695357914383 0.26752656530042 mirMAP -0.101731484521841 0.02227566071201 NA NA NA hsa-miR-23a-3p XIAP 1.10685926969665 3.16223452471768e-08 0.188695357914383 0.26752656530042 MirTarget;miRNATAP -0.166198298730543 0.00490865346531272 26439986 Moreover miR-23a expression correlated inversely with the expression of target gene X-linked inhibitor of apoptosis protein XIAP but positively with the caspase-3/7 activity liver cancer hsa-miR-23b-3p XIAP -0.286465516491361 0.18664668472995 0.188695357914383 0.26752656530042 MirTarget;miRNATAP -0.150748366360872 0.0075327317682592 NA NA NA hsa-miR-27a-3p XIAP 1.29886998470345 2.68986118553486e-08 0.188695357914383 0.26752656530042 miRNATAP -0.148384475407046 0.00308776419703669 26662313 miR 27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK SMAC/DIABLO XIAP axis; After further investigation we indicated that the knockdown of miR-27a promoted the apoptosis via mitochondrial pathway in T-47D cells treated with CDDP depending on the BAK-second mitochondria-derived activator of caspase/direct IAP binding protein with low pI SMAC/DIABLO-X-linked inhibitor of apoptosis XIAP axis breast cancer hsa-miR-27b-3p XIAP 0.0836323965901755 0.725273923274 0.188695357914383 0.26752656530042 miRNATAP -0.174677599302474 0.000614822065631208 NA NA NA hsa-miR-337-3p XIAP -0.722905798364932 0.0337389336330079 0.188695357914383 0.26752656530042 mirMAP -0.0854638329117004 0.0155578348055031 NA NA NA hsa-miR-340-5p XIAP -0.164941927483643 0.529910509321278 0.188695357914383 0.26752656530042 mirMAP;miRNATAP -0.153023334325064 0.000895304263874043 NA NA NA hsa-miR-708-3p XIAP 0.623782703831307 0.275355868302311 0.188695357914383 0.26752656530042 mirMAP -0.0520668911885112 0.0130633814480361 NA NA NA hsa-miR-766-3p XIAP 0.362693027508444 0.224058260234353 0.188695357914383 0.26752656530042 mirMAP -0.124700847404795 0.00203195232365125 NA NA NA hsa-miR-9-3p XIAP 0.330346058941473 0.541111939982661 0.188695357914383 0.26752656530042 MirTarget -0.0611423666281213 0.00829370416513189 NA NA NA