miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-103a-3p	CD274	0.990919087251708	0.00468308601422847	2.22279412449515	0.0516111370736547	miRNAWalker2_validate	-0.483901377020577	0.010127083096146		NA	NA	NA
hsa-miR-106a-5p	CD274	3.98693608217557	9.37722470816656e-07	2.22279412449515	0.0516111370736547	MirTarget;miRNATAP	-0.236984996685837	0.00244589289765692		NA	NA	NA
hsa-miR-182-5p	CD274	5.86988712704738	1.22411588571584e-15	2.22279412449515	0.0516111370736547	mirMAP	-0.339706442437269	4.80944840181619e-05		NA	NA	NA
hsa-miR-200a-3p	CD274	6.336081120041	4.024313571871e-16	2.22279412449515	0.0516111370736547	MirTarget	-0.349325798251526	8.24128678574652e-06		NA	NA	NA
hsa-miR-20b-5p	CD274	4.5662923200279	4.75238200639144e-05	2.22279412449515	0.0516111370736547	MirTarget;miRNATAP	-0.192258791595886	0.000703899942107355	24468585	These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer		colorectal cancer
hsa-miR-324-5p	CD274	1.31253452379847	0.0116806680545163	2.22279412449515	0.0516111370736547	miRanda	-0.47313482826795	0.000139757569599412		NA	NA	NA
hsa-miR-429	CD274	6.39965293994036	1.96920201593608e-18	2.22279412449515	0.0516111370736547	miRanda	-0.414756964042163	4.97744617535068e-07		NA	NA	NA
hsa-miR-497-5p	CD274	-1.44150596209372	0.0225146607606395	2.22279412449515	0.0516111370736547	MirTarget	-0.383087599725002	0.000175050271995498		NA	NA	NA
hsa-miR-93-5p	CD274	2.65964181833033	2.58315947526774e-08	2.22279412449515	0.0516111370736547	MirTarget;miRNATAP	-0.455113489627987	0.000638032417442551		NA	NA	NA
hsa-miR-107	EGFR	1.49443409571439	0.000130594521065411	1.4001245301835	0.170261817468909	miRanda	-0.374480133657281	0.0119989353405936		NA	NA	NA
hsa-miR-125a-5p	EGFR	-1.32352790615388	0.00714301627309467	1.4001245301835	0.170261817468909	mirMAP	-0.42322860924045	0.000316823060379402	19881956;27094723;24484870	We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML	;progression;progression	ovarian cancer;retinoblastoma;acute myeloid leukemia
hsa-miR-128-3p	EGFR	1.36248409467631	0.00408435995818078	1.4001245301835	0.170261817468909	miRNAWalker2_validate;miRTarBase	-0.325270996219395	0.00791157440942446		NA	NA	NA
hsa-miR-141-3p	EGFR	7.30474126597325	1.45115996357606e-24	1.4001245301835	0.170261817468909	MirTarget	-0.162592315810738	0.0301652607619616	26025929	Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice	metastasis	breast cancer
hsa-miR-148b-5p	EGFR	2.80812018666078	3.97536665756679e-08	1.4001245301835	0.170261817468909	mirMAP	-0.287810299143976	0.00993634422968525		NA	NA	NA
hsa-miR-186-5p	EGFR	0.445443449112564	0.185447310527704	1.4001245301835	0.170261817468909	mirMAP	-0.72926872723882	2.99701181181913e-05		NA	NA	NA
hsa-miR-188-5p	EGFR	1.39111178824125	0.0251592818948912	1.4001245301835	0.170261817468909	mirMAP	-0.263000006285575	0.00496388298567065		NA	NA	NA
hsa-miR-192-3p	EGFR	0.84572845432662	0.480940346018965	1.4001245301835	0.170261817468909	mirMAP	-0.19627166733635	5.85182501324464e-05		NA	NA	NA
hsa-miR-192-5p	EGFR	1.77716187978541	0.113485496183047	1.4001245301835	0.170261817468909	mirMAP	-0.254778390974915	4.87299611634051e-07		NA	NA	NA
hsa-miR-194-3p	EGFR	1.91743783341496	0.105383373371284	1.4001245301835	0.170261817468909	MirTarget	-0.18150332146796	0.000207666578228104		NA	NA	NA
hsa-miR-200a-3p	EGFR	6.336081120041	4.024313571871e-16	1.4001245301835	0.170261817468909	MirTarget	-0.314197934364205	6.96888933660157e-06	26184032;19671845	MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells	drug resistance;cell migration;	lung squamous cell cancer;bladder cancer
hsa-miR-26b-3p	EGFR	0.985177548213122	0.0351427970185971	1.4001245301835	0.170261817468909	mirMAP	-0.334456182236821	0.00731279830838523		NA	NA	NA
hsa-miR-29b-2-5p	EGFR	-0.596051745078872	0.189540844841389	1.4001245301835	0.170261817468909	mirMAP	-0.650549075574319	2.87046383123889e-07		NA	NA	NA
hsa-miR-30a-3p	EGFR	-1.22212086897848	0.167565797592104	1.4001245301835	0.170261817468909	mirMAP	-0.214317153681821	0.000993490591329179		NA	NA	NA
hsa-miR-30a-5p	EGFR	-0.768430903969183	0.320487552854215	1.4001245301835	0.170261817468909	miRNAWalker2_validate	-0.276326861755088	0.000207968085523555		NA	NA	NA
hsa-miR-30d-3p	EGFR	-0.0740421896025512	0.857423650167556	1.4001245301835	0.170261817468909	mirMAP	-0.359102136603866	0.011859909248408		NA	NA	NA
hsa-miR-362-5p	EGFR	-1.22309034685697	0.0452665543907975	1.4001245301835	0.170261817468909	mirMAP	-0.429041522813014	4.85211172370353e-06		NA	NA	NA
hsa-miR-375	EGFR	3.3784490463318	0.0449946294355695	1.4001245301835	0.170261817468909	miRanda	-0.222319476304576	1.9252452765405e-11		NA	NA	NA
hsa-miR-3913-5p	EGFR	0.145645056779437	0.734844256690741	1.4001245301835	0.170261817468909	mirMAP	-0.331535671489347	0.0152207755768948		NA	NA	NA
hsa-miR-491-5p	EGFR	0.569358547192776	0.313310594748302	1.4001245301835	0.170261817468909	miRanda	-0.229160572107169	0.0288340582743867	25299770	This latter effect is due to direct targeting of epidermal growth factor receptor EGFR by miR-491-5p and consequent inhibition of downstream AKT and MAPK signalling pathways; Induction of apoptosis by miR-491-5p in this cell line is mimicked by a combination of EGFR inhibition together with a BH3-mimetic molecule		ovarian cancer
hsa-miR-501-5p	EGFR	1.0411896821345	0.0777206709183552	1.4001245301835	0.170261817468909	mirMAP	-0.248487981993569	0.0115830021743273		NA	NA	NA
hsa-miR-616-5p	EGFR	2.48416313933027	0.00318247475868827	1.4001245301835	0.170261817468909	mirMAP	-0.169095471865248	0.0493530207787848		NA	NA	NA
hsa-miR-7-1-3p	EGFR	1.43074343339835	0.00471215970502094	1.4001245301835	0.170261817468909	mirMAP	-0.478554115110538	2.53296595691169e-05		NA	NA	NA
hsa-miR-769-5p	EGFR	0.41777775802937	0.343089124193569	1.4001245301835	0.170261817468909	mirMAP	-0.299692076637094	0.0244461238532634		NA	NA	NA
hsa-miR-106b-5p	STAT3	2.80565545918114	1.14547999022566e-09	0.0160861395507963	0.957262386811393	miRNATAP	-0.109483404039862	0.00226965981619241	27325313	We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression		breast cancer
hsa-miR-320b	STAT3	0.20205459771295	0.727216419960509	0.0160861395507963	0.957262386811393	miRanda	-0.112145780614318	0.000117337048085059		NA	NA	NA
hsa-miR-590-5p	STAT3	1.51400888103768	0.0023888567923017	0.0160861395507963	0.957262386811393	miRanda;miRNATAP	-0.111984699334191	0.000922243125456699	27757042	We found that the AKT/ERK and STAT3 signaling pathways were activated by miR-590-5p overexpression		gastric cancer
hsa-miR-93-5p	STAT3	2.65964181833033	2.58315947526774e-08	0.0160861395507963	0.957262386811393	miRNAWalker2_validate;miRNATAP	-0.109567101305833	0.00160117146509212		NA	NA	NA