miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AKT2 0.298659498236324 0.00963231738125113 -0.163157777800721 0.0933816097673111 TargetScan -0.121773636908232 0.0205827447176555 NA NA NA hsa-miR-21-5p AKT2 2.21515015440792 6.0468197386674e-49 -0.163157777800721 0.0933816097673111 miRNAWalker2_validate -0.125319232582453 0.000121164702766457 NA NA NA hsa-miR-22-3p AKT2 0.530940324058038 8.6675746679475e-07 -0.163157777800721 0.0933816097673111 mirMAP -0.142765168845465 0.0100550488787565 NA NA NA hsa-miR-338-3p AKT2 -0.0138760121093551 0.956163634155272 -0.163157777800721 0.0933816097673111 mirMAP -0.119124406302102 2.38431138421264e-07 NA NA NA hsa-miR-106a-5p AKT3 0.587427028487119 0.00838999163993323 -0.273001052722672 0.188651193580836 miRNATAP -0.2388542477399 2.17572670318915e-05 NA NA NA hsa-miR-106b-5p AKT3 1.08518388423396 4.82746923373852e-09 -0.273001052722672 0.188651193580836 miRNATAP -0.63116532758866 4.23753205402999e-25 NA NA NA hsa-miR-107 AKT3 0.85152957824299 1.22369651446858e-11 -0.273001052722672 0.188651193580836 PITA;miRanda -0.756112102935537 7.89013248827764e-16 NA NA NA hsa-miR-140-5p AKT3 0.132398579631585 0.457960134430787 -0.273001052722672 0.188651193580836 miRanda -0.347730244309107 8.60477835366952e-07 NA NA NA hsa-miR-142-3p AKT3 1.80134804047727 3.87649742898476e-07 -0.273001052722672 0.188651193580836 miRanda -0.243960154172525 2.78669142941441e-13 NA NA NA hsa-miR-146b-5p AKT3 2.23105707690238 3.83997814011313e-23 -0.273001052722672 0.188651193580836 miRNAWalker2_validate -0.255166569260379 5.2556904982786e-07 NA NA NA hsa-miR-15a-5p AKT3 1.07800995489566 4.32072598796529e-10 -0.273001052722672 0.188651193580836 miRNAWalker2_validate;miRTarBase;miRNATAP -0.604304838648006 1.49448472656197e-19 NA NA NA hsa-miR-15b-5p AKT3 0.637819606405168 0.000580041575431604 -0.273001052722672 0.188651193580836 miRNATAP -0.67973843202396 2.01070149868433e-28 NA NA NA hsa-miR-16-5p AKT3 0.468459442059375 0.02635007201346 -0.273001052722672 0.188651193580836 miRNAWalker2_validate;miRTarBase;miRNATAP -0.568045037958797 4.87003529234726e-25 NA NA NA hsa-miR-17-3p AKT3 1.37838995268509 5.00444740462873e-13 -0.273001052722672 0.188651193580836 miRNATAP -0.477549087236799 3.52641498743937e-15 NA NA NA hsa-miR-17-5p AKT3 1.57209612312313 5.10453838016207e-11 -0.273001052722672 0.188651193580836 TargetScan;miRNATAP -0.465520585359035 3.92511879234349e-23 NA NA NA hsa-miR-181a-5p AKT3 1.39352013383959 4.74824377258519e-17 -0.273001052722672 0.188651193580836 miRNATAP -0.296440897727793 3.58933749648964e-05 NA NA NA hsa-miR-181b-5p AKT3 1.44365471425231 6.03807007335243e-15 -0.273001052722672 0.188651193580836 miRNATAP -0.30554924094169 2.11059007168117e-06 NA NA NA hsa-miR-20a-5p AKT3 1.57190995476158 8.72275528729458e-12 -0.273001052722672 0.188651193580836 miRNATAP -0.399852243068736 1.83576734204372e-15 NA NA NA hsa-miR-22-3p AKT3 0.530940324058038 8.6675746679475e-07 -0.273001052722672 0.188651193580836 miRNATAP -0.243446737560933 0.0413079544237688 NA NA NA hsa-miR-29a-3p AKT3 -0.235052170104117 0.138527567930958 -0.273001052722672 0.188651193580836 miRNATAP -0.481734004083601 8.99237467028005e-10 NA NA NA hsa-miR-29b-2-5p AKT3 -0.39718520927539 0.0233851474877787 -0.273001052722672 0.188651193580836 mirMAP -0.18854298003376 0.00966484577986954 NA NA NA hsa-miR-29b-3p AKT3 0.0225365195743876 0.914313337784307 -0.273001052722672 0.188651193580836 miRNATAP -0.512613147987846 2.1060849979224e-19 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-320a AKT3 0.451741078692272 0.00893327237386749 -0.273001052722672 0.188651193580836 PITA;miRanda;miRNATAP -0.227893659314064 0.00195741110005248 NA NA NA hsa-miR-320b AKT3 1.21733873788625 7.99882585998487e-07 -0.273001052722672 0.188651193580836 PITA;miRanda;miRNATAP -0.349946231431661 4.55044321819242e-13 NA NA NA hsa-miR-335-3p AKT3 2.29463721765513 4.1956113745077e-18 -0.273001052722672 0.188651193580836 mirMAP -0.30313372364369 2.03502007738655e-12 NA NA NA hsa-miR-33a-3p AKT3 0.21453033253985 0.371591474252951 -0.273001052722672 0.188651193580836 mirMAP -0.472983796155366 5.05969351316599e-20 NA NA NA hsa-miR-340-5p AKT3 0.344103676703511 0.0160638942614091 -0.273001052722672 0.188651193580836 mirMAP -0.247728416119388 0.0058369886677658 NA NA NA hsa-miR-362-3p AKT3 0.994614346444282 4.39793878186399e-05 -0.273001052722672 0.188651193580836 miRanda -0.431690312253611 6.06358027466994e-18 NA NA NA hsa-miR-362-5p AKT3 1.45312548529729 9.37098891085093e-09 -0.273001052722672 0.188651193580836 PITA;TargetScan;miRNATAP -0.314823022647034 2.2336023315157e-11 NA NA NA hsa-miR-369-3p AKT3 0.644921905467686 0.00104986428608648 -0.273001052722672 0.188651193580836 mirMAP -0.258474022492291 5.39025552593403e-05 NA NA NA hsa-miR-374a-5p AKT3 0.239597788731458 0.0202963000797544 -0.273001052722672 0.188651193580836 mirMAP -0.412183820224296 0.00115229496586381 NA NA NA hsa-miR-409-3p AKT3 1.02296003511803 1.54748197930307e-08 -0.273001052722672 0.188651193580836 PITA;mirMAP -0.163474825992855 0.0175312737806419 NA NA NA hsa-miR-421 AKT3 1.26653675546617 2.35180826009926e-08 -0.273001052722672 0.188651193580836 miRanda;mirMAP -0.314340685542377 4.9943728259466e-09 NA NA NA hsa-miR-424-5p AKT3 0.956135912596328 0.00035164943928494 -0.273001052722672 0.188651193580836 miRNATAP -0.335493140663715 7.54630340718379e-14 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 1.88467797720099 9.65178855450719e-15 -0.273001052722672 0.188651193580836 miRNATAP -0.450105998191059 5.87603301592361e-23 NA NA NA hsa-miR-502-3p AKT3 0.989057260587538 3.37032335853725e-07 -0.273001052722672 0.188651193580836 miRNATAP -0.584189726633833 5.98074147538183e-23 NA NA NA hsa-miR-502-5p AKT3 0.873538712251823 0.0012275719769761 -0.273001052722672 0.188651193580836 PITA;miRNATAP -0.352513250404314 1.89754896008479e-11 NA NA NA hsa-miR-505-3p AKT3 0.68973424635459 0.00225185811813183 -0.273001052722672 0.188651193580836 mirMAP -0.427036086270006 8.10939959640155e-16 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-539-5p AKT3 0.455406484803261 0.10846447950775 -0.273001052722672 0.188651193580836 mirMAP;miRNATAP -0.1387220122356 0.00223160583874989 NA NA NA hsa-miR-542-3p AKT3 1.12416854979951 1.02649534578738e-12 -0.273001052722672 0.188651193580836 miRanda -0.281961851589184 0.00026441191767321 NA NA NA hsa-miR-577 AKT3 0.615893340074725 0.210494450869356 -0.273001052722672 0.188651193580836 mirMAP -0.207115000396204 9.2562926093692e-15 NA NA NA hsa-miR-769-5p AKT3 0.933922223076232 1.9485893796755e-09 -0.273001052722672 0.188651193580836 PITA;miRNATAP -0.434363941162121 2.76713270484797e-08 NA NA NA hsa-miR-93-5p AKT3 1.68243825551104 4.62947431501061e-15 -0.273001052722672 0.188651193580836 miRNATAP -0.424661897302067 1.5335508992555e-15 NA NA NA hsa-miR-146b-5p ANGPT1 2.23105707690238 3.83997814011313e-23 -1.11728763573643 2.03295126213193e-06 miRanda -0.355487898065865 9.44163829721527e-10 NA NA NA hsa-miR-335-3p ANGPT1 2.29463721765513 4.1956113745077e-18 -1.11728763573643 2.03295126213193e-06 mirMAP -0.349314779228241 2.36033064642181e-12 NA NA NA hsa-miR-429 ANGPT1 1.58250682050303 4.75828087352234e-05 -1.11728763573643 2.03295126213193e-06 miRanda -0.322523178151543 3.24680965513092e-20 NA NA NA hsa-miR-590-3p ANGPT1 0.858742926831233 0.000127281269371976 -1.11728763573643 2.03295126213193e-06 PITA;miRanda;mirMAP -0.537126669639634 1.0448314417353e-18 NA NA NA hsa-miR-125a-5p ANGPT2 -0.261743402170195 0.116107665196876 1.52873448540757 9.92373200784565e-16 miRanda -0.16627815194417 0.0264181223187478 NA NA NA hsa-miR-145-5p ANGPT2 -1.54503595327403 2.65080161523141e-09 1.52873448540757 9.92373200784565e-16 MirTarget;miRNATAP -0.212340353947003 2.94469909297938e-06 24384875;27570490 miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer ; kidney renal cell cancer;pancreatic cancer hsa-let-7a-3p ATF2 0.283468597868531 0.127007787220086 0.00751297901652315 0.935680993832167 MirTarget;mirMAP;miRNATAP -0.155726632379181 2.10552836040338e-07 NA NA NA hsa-let-7b-3p ATF2 0.377956364821509 0.0061730103051373 0.00751297901652315 0.935680993832167 MirTarget;mirMAP;miRNATAP -0.106926333625152 0.00982086309932882 NA NA NA hsa-miR-10b-5p ATF2 -0.2493192229845 0.144956122242922 0.00751297901652315 0.935680993832167 MirTarget;miRNATAP -0.121294127328671 0.000246678620693019 NA NA NA hsa-miR-126-5p ATF2 0.450893496822779 0.0112966412858755 0.00751297901652315 0.935680993832167 mirMAP -0.143898565684946 4.61368386482945e-06 NA NA NA hsa-miR-26a-5p ATF2 -0.507487084157331 3.23715933371269e-05 0.00751297901652315 0.935680993832167 MirTarget;miRNATAP -0.205448001436543 8.3368639360385e-06 NA NA NA hsa-miR-26b-5p ATF2 -0.499493687076043 0.0118149973400486 0.00751297901652315 0.935680993832167 MirTarget;miRNATAP -0.169377403502644 9.25519075804041e-10 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-299-5p ATF2 -0.162422032147768 0.435278723340297 0.00751297901652315 0.935680993832167 miRNATAP -0.103583626193024 0.00014810554330296 NA NA NA hsa-miR-30b-5p ATF2 -0.0106833209203501 0.954966272944722 0.00751297901652315 0.935680993832167 mirMAP -0.205316965984661 1.15329823948348e-12 NA NA NA hsa-miR-30c-5p ATF2 -0.172645077009891 0.276411433016536 0.00751297901652315 0.935680993832167 mirMAP -0.184606355553008 1.75932251297648e-07 NA NA NA hsa-miR-320a ATF2 0.451741078692272 0.00893327237386749 0.00751297901652315 0.935680993832167 miRanda -0.114567519031305 0.000447167732244904 NA NA NA hsa-miR-369-3p ATF2 0.644921905467686 0.00104986428608648 0.00751297901652315 0.935680993832167 MirTarget;PITA;miRNATAP -0.104421567555505 0.000253031862969158 NA NA NA hsa-miR-374a-5p ATF2 0.239597788731458 0.0202963000797544 0.00751297901652315 0.935680993832167 mirMAP -0.126078889003768 0.0261207094718845 NA NA NA hsa-miR-374b-5p ATF2 0.00249900187478502 0.985380083859555 0.00751297901652315 0.935680993832167 miRNAWalker2_validate;mirMAP;miRNATAP -0.225304940095209 5.02061990499497e-08 NA NA NA hsa-miR-103a-3p BCL2 1.01322687786547 1.60813894223583e-11 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.342379556752644 7.6824626909566e-06 NA NA NA hsa-miR-126-5p BCL2 0.450893496822779 0.0112966412858755 -0.899142762694703 2.93311234351261e-06 mirMAP -0.301105791117778 6.33068273627289e-06 NA NA NA hsa-miR-130b-5p BCL2 1.47709791778827 1.34679413565661e-06 -0.899142762694703 2.93311234351261e-06 mirMAP -0.300247989068655 3.69743919415252e-16 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-136-5p BCL2 0.501768051727903 0.0272130411225693 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.17779316149359 0.000701933942815507 NA NA NA hsa-miR-148a-3p BCL2 -0.18108394434325 0.495345303586758 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.155639676145632 0.000533827688012766 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-15a-5p BCL2 1.07800995489566 4.32072598796529e-10 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.382947945084909 6.12551340620688e-09 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 0.811179945491507 0.000927520880593552 -0.899142762694703 2.93311234351261e-06 mirMAP -0.397701597338993 2.34881009347574e-18 18449891;25594541;26915294;26884837 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression drug resistance;;poor survival; gastric cancer;breast cancer;lung cancer;liver cancer hsa-miR-15b-5p BCL2 0.637819606405168 0.000580041575431604 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.487012003866561 1.64331477205887e-15 18449891;25594541;26915294;26884837 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression drug resistance;;poor survival; gastric cancer;breast cancer;lung cancer;liver cancer hsa-miR-16-1-3p BCL2 1.23864765632542 1.24544799589822e-08 -0.899142762694703 2.93311234351261e-06 mirMAP -0.282734232855026 1.96976466813529e-07 18931683 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 prostate cancer hsa-miR-16-2-3p BCL2 0.869267463341732 0.000785361809327569 -0.899142762694703 2.93311234351261e-06 mirMAP -0.305851125033161 4.26063951557552e-12 NA NA NA hsa-miR-16-5p BCL2 0.468459442059375 0.02635007201346 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.307544967095245 3.1475788390589e-08 18449891;21336967;24447552;25435430;24598659;18931683;22966344;25623762 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells drug resistance;;worse prognosis;;;;poor survival;drug resistance gastric cancer;liver cancer;lymphoma;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-17-5p BCL2 1.57209612312313 5.10453838016207e-11 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.335214889051797 4.02760065493226e-13 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181a-5p BCL2 1.39352013383959 4.74824377258519e-17 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.258210300397206 0.000141372228195464 24267199;23740615;25524579;27534652;24335172 Bufalin was found to induce the expression of miR-181a a small non-coding RNA believed to induce apoptosis by repressing its target gene BCL-2; In prostate cancer PC-3cell line bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation;The results from Western blotting indicated that miR-181a might be associated with the up-regulation of bcl-2 and matrix metalloproteinase 9 and the down-regulation of tissue inhibitor of metalloproteinases-3 and p21 in MG63 cells;Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression;In addition inhibition of miR-181a promoted apoptosis of HeLa and CaSKi cells due to increasing Bax expression and decreasing Bcl-2 expression;The function role of miR 181a in chemosensitivity to adriamycin by targeting Bcl 2 in low invasive breast cancer cells; Luciferase reporter vector with the putative BCL-2 3' untranslated region 3'UTR was constructed to explore whether BCL-2 was a direct target gene of miR-181a; Real-time PCR was performed to test the expression of miR-181a and Bcl-2 in the selected breast cancer tissue samples; Transfected with miR-181a mimic in cells resulted in the decreased expression of Bcl-2; At least in part the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of miR-181a enhanced adriamycin-induced apoptosis via targeting Bcl-2 ;;;; prostate cancer;sarcoma;lung squamous cell cancer;cervical and endocervical cancer;breast cancer hsa-miR-181b-5p BCL2 1.44365471425231 6.03807007335243e-15 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.301605362768947 6.62371767382316e-07 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-182-5p BCL2 1.73826081735237 5.69817940588551e-09 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.281139475876817 3.62164489087682e-14 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-186-5p BCL2 0.35512789129261 0.0196931838168008 -0.899142762694703 2.93311234351261e-06 mirMAP -0.381047109248084 1.09796348306849e-06 NA NA NA hsa-miR-192-5p BCL2 2.0867723747501 3.57854249239079e-08 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.219076747701746 8.11784107313729e-14 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 4.51951031652328 7.04026169031626e-18 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.135038964160811 5.10281494563971e-11 NA NA NA hsa-miR-200a-5p BCL2 2.19152245759943 3.17968183522514e-11 -0.899142762694703 2.93311234351261e-06 mirMAP -0.27726591358478 2.73221347510694e-17 NA NA NA hsa-miR-200b-3p BCL2 2.06025765178663 3.07718049337497e-10 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.26795392182203 1.0913241181438e-15 NA NA NA hsa-miR-200b-5p BCL2 0.934206940937576 0.00554096871767416 -0.899142762694703 2.93311234351261e-06 mirMAP -0.269850401550945 2.00719148228126e-14 NA NA NA hsa-miR-200c-3p BCL2 1.74925752003763 3.42000026705311e-08 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.320842719761782 4.38895009841552e-21 NA NA NA hsa-miR-20a-3p BCL2 0.703027135708586 0.022464856696655 -0.899142762694703 2.93311234351261e-06 mirMAP -0.243080236722433 3.83821044129985e-10 NA NA NA hsa-miR-20a-5p BCL2 1.57190995476158 8.72275528729458e-12 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.266605223273104 5.09581999167075e-08 NA NA NA hsa-miR-21-5p BCL2 2.21515015440792 6.0468197386674e-49 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.40068246416158 5.43440909882672e-10 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 1.10296552366805 0.0225256935718223 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.109875079706307 5.99327555192393e-06 NA NA NA hsa-miR-224-5p BCL2 1.11923763019015 0.000974728485303372 -0.899142762694703 2.93311234351261e-06 mirMAP -0.200216081669974 3.92630015720796e-09 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 0.939979588719366 2.77281797589097e-05 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.263894680703146 3.54075573905773e-07 NA NA NA hsa-miR-29a-5p BCL2 1.00715634051951 4.47499137997344e-07 -0.899142762694703 2.93311234351261e-06 mirMAP -0.30932038928841 8.74631087986786e-08 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 0.0225365195743876 0.914313337784307 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.198517403350232 0.000523509891552837 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-30d-3p BCL2 0.0608340295673737 0.708110230223927 -0.899142762694703 2.93311234351261e-06 mirMAP -0.252389142623314 0.000684241763487853 NA NA NA hsa-miR-335-3p BCL2 2.29463721765513 4.1956113745077e-18 -0.899142762694703 2.93311234351261e-06 mirMAP -0.268016796875566 5.753163435092e-11 NA NA NA hsa-miR-338-5p BCL2 -0.420442436641152 0.0583175290447746 -0.899142762694703 2.93311234351261e-06 PITA -0.124048509127431 0.022100499664932 NA NA NA hsa-miR-33a-5p BCL2 0.372183130885047 0.335617783855811 -0.899142762694703 2.93311234351261e-06 mirMAP -0.187397433435176 4.13736589904427e-10 NA NA NA hsa-miR-34a-5p BCL2 0.691825068787607 0.00069818668499891 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.329985813813796 6.99247696897484e-09 24988056;18803879;24565525;23155233;24444609;20687223;22623155;19714243;25053345;20433755;21399894;22964582;23862748 Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression ;poor survival;differentiation;drug resistance;;poor survival;drug resistance;;poor survival;drug resistance;;;; gastric cancer;gastric cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-409-3p BCL2 1.02296003511803 1.54748197930307e-08 -0.899142762694703 2.93311234351261e-06 mirMAP -0.249306590530499 0.000107202832832321 NA NA NA hsa-miR-429 BCL2 1.58250682050303 4.75828087352234e-05 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.240238418690481 1.24621969812778e-16 26513239;23999873;26511969 MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; gastric cancer;esophageal cancer;glioblastoma hsa-miR-450b-5p BCL2 1.36137774989901 7.45499130609203e-11 -0.899142762694703 2.93311234351261e-06 mirMAP -0.233477398914929 2.03093227176541e-05 NA NA NA hsa-miR-452-5p BCL2 0.612108901803716 0.0110020550949664 -0.899142762694703 2.93311234351261e-06 mirMAP -0.19866322434232 5.33384755553303e-05 NA NA NA hsa-miR-455-5p BCL2 0.644390760445571 0.00262275997170695 -0.899142762694703 2.93311234351261e-06 mirMAP -0.396712641936315 9.54147980700326e-14 NA NA NA hsa-miR-542-3p BCL2 1.12416854979951 1.02649534578738e-12 -0.899142762694703 2.93311234351261e-06 mirMAP -0.215257770709208 0.00329622139421902 NA NA NA hsa-miR-577 BCL2 0.615893340074725 0.210494450869356 -0.899142762694703 2.93311234351261e-06 PITA -0.141656139039771 4.69420313328151e-08 NA NA NA hsa-miR-582-5p BCL2 0.0720675907490005 0.728284850619144 -0.899142762694703 2.93311234351261e-06 PITA -0.124068975744705 0.0330435180032155 NA NA NA hsa-miR-590-3p BCL2 0.858742926831233 0.000127281269371976 -0.899142762694703 2.93311234351261e-06 miRanda;mirMAP -0.318339749200423 6.43915706978043e-10 NA NA NA hsa-miR-590-5p BCL2 0.932604531809045 8.39043954167884e-05 -0.899142762694703 2.93311234351261e-06 miRanda -0.325395689444373 1.59229763950107e-11 NA NA NA hsa-miR-629-5p BCL2 0.812778109967063 7.88203035554668e-05 -0.899142762694703 2.93311234351261e-06 mirMAP -0.272239447772002 1.74083722051538e-06 NA NA NA hsa-miR-7-1-3p BCL2 0.94398354303717 7.5771319809992e-05 -0.899142762694703 2.93311234351261e-06 mirMAP -0.313200679489903 6.86559579820048e-11 NA NA NA hsa-miR-7-5p BCL2 1.20202447072014 0.000123775346787165 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.26584380813364 7.84866931741742e-12 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-96-5p BCL2 1.44821155854693 6.56312590328933e-06 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;TargetScan -0.256121183455027 9.63548441575232e-12 NA NA NA hsa-let-7c-5p BCL2L1 -0.148489254129201 0.548077841857242 0.538910243524146 0.000232226072126618 miRNAWalker2_validate;miRTarBase -0.173534489241295 1.50926265717428e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-133a-3p BCL2L1 -2.63342156915404 5.72661351480585e-12 0.538910243524146 0.000232226072126618 miRNAWalker2_validate -0.109066541881666 9.61762914141871e-07 23756231 Furthermore bioinformatic prediction and experimental validation were applied to identify target genes of miR-133a and the results revealed that the anti-tumor effect of miR-133a was probably due to targeting and repressing of Bcl-xL and Mcl-1 expression sarcoma hsa-miR-23b-3p BCL2L1 -0.228571473429 0.0553601132069074 0.538910243524146 0.000232226072126618 miRNAWalker2_validate -0.274620801431438 0.000374432863426817 NA NA NA hsa-miR-195-5p BCL2L11 -1.07154705036962 4.16544134775761e-08 0.413923585963092 0.000434820349815219 miRNAWalker2_validate -0.134807821070255 0.000183366667864393 NA NA NA hsa-miR-30a-5p BCL2L11 -0.742755040631906 3.79943871404435e-05 0.413923585963092 0.000434820349815219 miRNATAP -0.112582912725267 0.00471913470145255 NA NA NA hsa-miR-30c-5p BCL2L11 -0.172645077009891 0.276411433016536 0.413923585963092 0.000434820349815219 miRNATAP -0.105947461463742 0.0220936558786676 NA NA NA hsa-miR-338-5p BCL2L11 -0.420442436641152 0.0583175290447746 0.413923585963092 0.000434820349815219 PITA -0.125701070309261 0.000107849245598195 NA NA NA hsa-miR-140-3p BDNF -0.0247056136502994 0.830704277191343 0.102820700178842 0.623749062715991 PITA;miRNATAP -0.291393262501683 0.0107134620178566 NA NA NA hsa-miR-30e-5p BDNF -0.284839730810255 0.0405852891523165 0.102820700178842 0.623749062715991 miRNATAP -0.188573165378672 0.0440469002707359 NA NA NA hsa-miR-338-5p BDNF -0.420442436641152 0.0583175290447746 0.102820700178842 0.623749062715991 miRNATAP -0.148320337878038 0.0103240137802644 NA NA NA hsa-miR-199a-5p BRCA1 0.723739336873244 5.69674696426761e-05 1.22390922813628 2.15408524997881e-16 miRanda -0.15586425763082 0.00349557666742734 NA NA NA hsa-miR-199b-5p BRCA1 0.621733599295605 0.000811860893066088 1.22390922813628 2.15408524997881e-16 miRanda -0.139698759474156 0.0071659314921011 NA NA NA hsa-let-7a-5p CASP9 0.298659498236324 0.00963231738125113 -0.538812245140001 5.30209860086014e-09 miRNAWalker2_validate -0.127035389586059 0.013347946592267 NA NA NA hsa-miR-15a-5p CASP9 1.07800995489566 4.32072598796529e-10 -0.538812245140001 5.30209860086014e-09 mirMAP -0.123245680093592 0.000140094207419561 NA NA NA hsa-miR-199a-3p CASP9 1.04459501900922 2.43330173715104e-11 -0.538812245140001 5.30209860086014e-09 mirMAP -0.164028720506034 3.64653398829862e-06 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 1.04524477057703 2.47846951108535e-11 -0.538812245140001 5.30209860086014e-09 mirMAP -0.163745200067572 3.70661320324365e-06 NA NA NA hsa-miR-195-5p CCND1 -1.07154705036962 4.16544134775761e-08 0.720140419027159 0.000259727836476946 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.270917365501396 6.99604795762646e-06 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-20b-5p CCND1 -0.251408129904656 0.380168040769502 0.720140419027159 0.000259727836476946 MirTarget;miRNATAP -0.181499833751399 1.59769536732368e-05 NA NA NA hsa-miR-29c-3p CCND1 -1.34143813218298 2.77493790306384e-12 0.720140419027159 0.000259727836476946 mirMAP -0.156690297682041 0.0103577380850297 NA NA NA hsa-miR-365a-3p CCND1 -0.801671336684825 1.28258342849568e-06 0.720140419027159 0.000259727836476946 miRNAWalker2_validate;miRTarBase -0.152931546885566 0.036209208118448 NA NA NA hsa-miR-497-5p CCND1 -0.486115215577409 0.00973897247186318 0.720140419027159 0.000259727836476946 MirTarget;miRNATAP -0.194638254202971 0.00265856864276364 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-9-5p CCND1 -0.887069929841985 0.00529865051479737 0.720140419027159 0.000259727836476946 miRNAWalker2_validate -0.13860444352194 0.000243216592859737 NA NA NA hsa-let-7a-3p CCND2 0.283468597868531 0.127007787220086 -0.266828347557643 0.311200298179232 mirMAP -0.371567678699036 1.66719392222442e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.377956364821509 0.0061730103051373 -0.266828347557643 0.311200298179232 mirMAP -0.402202198292367 0.0006265673802009 NA NA NA hsa-let-7f-1-3p CCND2 1.09636075438131 3.42037366931931e-10 -0.266828347557643 0.311200298179232 mirMAP -0.421511592056269 1.88495018273279e-06 NA NA NA hsa-let-7f-5p CCND2 0.300925310468863 0.0221019558342241 -0.266828347557643 0.311200298179232 miRNATAP -0.346620357429191 0.00536667928289417 NA NA NA hsa-let-7g-5p CCND2 0.296128761926282 0.0296823495976068 -0.266828347557643 0.311200298179232 miRNATAP -0.520425112934185 1.17109619787272e-05 NA NA NA hsa-miR-106a-5p CCND2 0.587427028487119 0.00838999163993323 -0.266828347557643 0.311200298179232 miRNATAP -0.174204880562388 0.0158246906330611 NA NA NA hsa-miR-106b-5p CCND2 1.08518388423396 4.82746923373852e-09 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.583236779534434 7.66528568514347e-13 NA NA NA hsa-miR-10b-3p CCND2 0.448860145188521 0.00703361939318676 -0.266828347557643 0.311200298179232 mirMAP -0.326004457342762 0.000776508252441517 NA NA NA hsa-miR-130b-5p CCND2 1.47709791778827 1.34679413565661e-06 -0.266828347557643 0.311200298179232 mirMAP -0.356434702320189 1.36407707081637e-12 NA NA NA hsa-miR-141-3p CCND2 1.76274853293464 9.99331900755725e-07 -0.266828347557643 0.311200298179232 MirTarget;TargetScan -0.255901572354203 1.68526590919642e-09 NA NA NA hsa-miR-151a-3p CCND2 0.968493853072108 1.28305876770564e-12 -0.266828347557643 0.311200298179232 mirMAP -0.530145130595398 2.77401247065126e-06 NA NA NA hsa-miR-15a-5p CCND2 1.07800995489566 4.32072598796529e-10 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.472165099151573 1.14414004078959e-07 NA NA NA hsa-miR-15b-5p CCND2 0.637819606405168 0.000580041575431604 -0.266828347557643 0.311200298179232 miRNATAP -0.516489712340691 8.53499810619317e-10 NA NA NA hsa-miR-16-2-3p CCND2 0.869267463341732 0.000785361809327569 -0.266828347557643 0.311200298179232 mirMAP -0.395226309980272 3.27988952149559e-11 NA NA NA hsa-miR-16-5p CCND2 0.468459442059375 0.02635007201346 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRNATAP -0.516132357400658 2.11146706317975e-12 NA NA NA hsa-miR-17-5p CCND2 1.57209612312313 5.10453838016207e-11 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.301614795379694 2.3679331749879e-06 NA NA NA hsa-miR-181a-2-3p CCND2 0.761758815767271 3.4163207928657e-06 -0.266828347557643 0.311200298179232 mirMAP -0.245234247483269 0.0118441456744301 NA NA NA hsa-miR-182-5p CCND2 1.73826081735237 5.69817940588551e-09 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.337872116023098 2.21608132770386e-11 NA NA NA hsa-miR-183-5p CCND2 2.08412478942637 1.08931431254487e-10 -0.266828347557643 0.311200298179232 miRNATAP -0.315775206761385 8.35703763428762e-12 NA NA NA hsa-miR-185-5p CCND2 1.20157041272762 3.03584066444936e-15 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.504279725930662 3.95675575027617e-07 NA NA NA hsa-miR-186-5p CCND2 0.35512789129261 0.0196931838168008 -0.266828347557643 0.311200298179232 mirMAP;miRNATAP -0.482985631115684 4.61104498921406e-06 NA NA NA hsa-miR-188-5p CCND2 1.57437249320621 2.78824007819973e-08 -0.266828347557643 0.311200298179232 PITA;mirMAP -0.284821735797616 6.47899773985816e-07 NA NA NA hsa-miR-191-5p CCND2 1.00768250372273 1.6683382013374e-05 -0.266828347557643 0.311200298179232 MirTarget -0.30302138483538 6.11450636907225e-06 NA NA NA hsa-miR-19a-3p CCND2 1.71062381299889 1.72281025366819e-11 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.266590112566253 9.32456075860399e-06 NA NA NA hsa-miR-19b-3p CCND2 0.936987029203338 9.28141970787798e-06 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;MirTarget;miRNATAP -0.347119617809494 2.8600708950686e-06 NA NA NA hsa-miR-200a-3p CCND2 2.02394729844446 2.21240501925011e-08 -0.266828347557643 0.311200298179232 MirTarget -0.219287797903635 2.3044254482718e-07 NA NA NA hsa-miR-20a-5p CCND2 1.57190995476158 8.72275528729458e-12 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;miRNATAP -0.225612289455958 0.000751726268016441 NA NA NA hsa-miR-21-3p CCND2 1.87780012411493 8.38052480155167e-17 -0.266828347557643 0.311200298179232 mirMAP -0.307356816380523 3.60292632960926e-06 NA NA NA hsa-miR-2355-3p CCND2 0.101789577163865 0.693158423682028 -0.266828347557643 0.311200298179232 miRNATAP -0.157835076491116 0.0157147007005435 NA NA NA hsa-miR-26a-2-3p CCND2 0.0619487388777404 0.765401751442771 -0.266828347557643 0.311200298179232 mirMAP -0.182180566976712 0.0217151994827193 NA NA NA hsa-miR-26a-5p CCND2 -0.507487084157331 3.23715933371269e-05 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.344937807080709 0.00960894332117683 NA NA NA hsa-miR-26b-5p CCND2 -0.499493687076043 0.0118149973400486 -0.266828347557643 0.311200298179232 mirMAP;miRNATAP -0.345312855192381 1.73514462922748e-05 NA NA NA hsa-miR-29a-5p CCND2 1.00715634051951 4.47499137997344e-07 -0.266828347557643 0.311200298179232 mirMAP -0.182159842353673 0.0218809184565078 24130168;22330340 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator ; gastric cancer;sarcoma hsa-miR-29b-3p CCND2 0.0225365195743876 0.914313337784307 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.210269851977998 0.00652543437036925 24130168;22330340 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator ; gastric cancer;sarcoma hsa-miR-301a-3p CCND2 1.22580753116505 5.84016077664577e-09 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.360576735570157 8.69435503941875e-07 NA NA NA hsa-miR-3065-3p CCND2 -0.00685158653722073 0.979081293235379 -0.266828347557643 0.311200298179232 MirTarget;miRNATAP -0.195896970627541 0.00146414341100635 NA NA NA hsa-miR-30e-3p CCND2 -0.444998679251398 0.000501880465265124 -0.266828347557643 0.311200298179232 mirMAP -0.264578867443002 0.0383806221737476 NA NA NA hsa-miR-320a CCND2 0.451741078692272 0.00893327237386749 -0.266828347557643 0.311200298179232 miRNAWalker2_validate;mirMAP;miRNATAP -0.29462773696815 0.0015958349522217 NA NA NA hsa-miR-320b CCND2 1.21733873788625 7.99882585998487e-07 -0.266828347557643 0.311200298179232 mirMAP;miRNATAP -0.360458427482597 7.75494430819454e-09 NA NA NA hsa-miR-323a-3p CCND2 0.308398343176418 0.29758426681013 -0.266828347557643 0.311200298179232 miRNATAP -0.142895041606599 0.0127859472840689 NA NA NA hsa-miR-324-3p CCND2 0.903513852828114 7.41223794911022e-07 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.370821862924607 1.63600931085595e-05 NA NA NA hsa-miR-331-5p CCND2 0.703863188605486 4.25406757208802e-05 -0.266828347557643 0.311200298179232 miRNATAP -0.460664182751042 5.50959293469208e-07 NA NA NA hsa-miR-335-5p CCND2 0.576542642348884 0.01886326850059 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.226680120351377 0.000529223705272384 NA NA NA hsa-miR-33a-3p CCND2 0.21453033253985 0.371591474252951 -0.266828347557643 0.311200298179232 MirTarget -0.269105519919619 0.000115590594987793 NA NA NA hsa-miR-3607-3p CCND2 0.479939234340415 0.251616873367277 -0.266828347557643 0.311200298179232 mirMAP -0.119250048528772 0.00252486402934898 NA NA NA hsa-miR-374b-3p CCND2 0.286271228061054 0.169086077672581 -0.266828347557643 0.311200298179232 mirMAP -0.211778548565297 0.00851440143083975 NA NA NA hsa-miR-423-5p CCND2 0.554579912507932 7.65114789083517e-05 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.492335489509232 1.57346886934602e-05 NA NA NA hsa-miR-424-5p CCND2 0.956135912596328 0.00035164943928494 -0.266828347557643 0.311200298179232 miRNATAP -0.244612937037276 3.39142248190113e-05 NA NA NA hsa-miR-429 CCND2 1.58250682050303 4.75828087352234e-05 -0.266828347557643 0.311200298179232 miRNATAP -0.201473724008651 7.13833700723638e-07 NA NA NA hsa-miR-500a-5p CCND2 1.33126717816499 3.1497328652235e-07 -0.266828347557643 0.311200298179232 mirMAP -0.313038292150231 1.31135877186835e-07 NA NA NA hsa-miR-501-5p CCND2 1.59306197632625 2.04856600619363e-09 -0.266828347557643 0.311200298179232 PITA;mirMAP;miRNATAP -0.330162641494821 4.26778581733722e-08 NA NA NA hsa-miR-503-5p CCND2 1.76009641313699 2.96580674020209e-09 -0.266828347557643 0.311200298179232 MirTarget -0.157878219724021 0.00422430184661587 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 1.55643544666056 8.53097422057455e-09 -0.266828347557643 0.311200298179232 MirTarget -0.379829000694252 2.57680359355204e-11 NA NA NA hsa-miR-577 CCND2 0.615893340074725 0.210494450869356 -0.266828347557643 0.311200298179232 PITA;mirMAP -0.150091119883405 2.07008309558727e-05 NA NA NA hsa-miR-589-3p CCND2 1.00357906465313 8.20399071001461e-05 -0.266828347557643 0.311200298179232 mirMAP -0.256663229095903 8.69400409941881e-05 NA NA NA hsa-miR-590-3p CCND2 0.858742926831233 0.000127281269371976 -0.266828347557643 0.311200298179232 miRanda;mirMAP -0.418266898886136 1.66524099584715e-09 NA NA NA hsa-miR-590-5p CCND2 0.932604531809045 8.39043954167884e-05 -0.266828347557643 0.311200298179232 mirMAP -0.356627609219485 6.26678679589055e-08 NA NA NA hsa-miR-660-5p CCND2 1.23607536548029 2.61099214897472e-10 -0.266828347557643 0.311200298179232 mirMAP -0.277964804570177 0.000471101509058194 NA NA NA hsa-miR-7-1-3p CCND2 0.94398354303717 7.5771319809992e-05 -0.266828347557643 0.311200298179232 mirMAP -0.264403230513261 6.47028686057144e-05 NA NA NA hsa-miR-877-5p CCND2 1.86786864338556 8.44059777969251e-10 -0.266828347557643 0.311200298179232 miRNAWalker2_validate -0.320187750770132 3.21509092017468e-09 NA NA NA hsa-miR-93-5p CCND2 1.68243825551104 4.62947431501061e-15 -0.266828347557643 0.311200298179232 miRNATAP -0.296309342090127 2.63797997444733e-05 NA NA NA hsa-miR-96-5p CCND2 1.44821155854693 6.56312590328933e-06 -0.266828347557643 0.311200298179232 TargetScan;miRNATAP -0.289502666598185 1.60886469433295e-08 NA NA NA hsa-miR-125b-5p CCNE1 -0.176364454911029 0.43771853581292 1.63902722877652 2.5095106440044e-08 miRNAWalker2_validate -0.328507585771565 4.93685520157516e-05 NA NA NA hsa-miR-195-5p CCNE1 -1.07154705036962 4.16544134775761e-08 1.63902722877652 2.5095106440044e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.508445516091264 1.96888625792722e-08 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.507487084157331 3.23715933371269e-05 1.63902722877652 2.5095106440044e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.32553784083694 0.0336914156199607 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -0.486115215577409 0.00973897247186318 1.63902722877652 2.5095106440044e-08 MirTarget;miRNATAP -0.422371825297681 1.45931369873543e-05 24112607;25909221;24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-26a-5p CCNE2 -0.507487084157331 3.23715933371269e-05 1.11137025866778 3.37127377164225e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.217991130222279 0.0187235945588459 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-28-3p CCNE2 -0.247525872199168 0.0399632425440147 1.11137025866778 3.37127377164225e-10 PITA;miRNATAP -0.463382853367312 7.31596729214753e-07 NA NA NA hsa-miR-30a-5p CCNE2 -0.742755040631906 3.79943871404435e-05 1.11137025866778 3.37127377164225e-10 miRNATAP -0.477869968613217 2.56757628817536e-16 NA NA NA hsa-miR-23b-3p CDK2 -0.228571473429 0.0553601132069074 0.749435872303729 1.57275104733674e-11 miRNAWalker2_validate -0.16727997063867 0.00572747591909996 NA NA NA hsa-miR-125a-3p CDK6 0.0862037949225951 0.688453004025032 0.990643124320291 1.17862667832619e-06 mirMAP -0.138883963795303 0.021370798857422 NA NA NA hsa-miR-129-5p CDK6 -1.61803714443871 4.93214379865694e-06 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate -0.138266138688225 0.000101863341844936 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129 gastric cancer hsa-miR-144-3p CDK6 -1.37061426401952 5.85913017989725e-05 0.990643124320291 1.17862667832619e-06 mirMAP -0.101833657078409 0.00635737230618311 NA NA NA hsa-miR-145-3p CDK6 -1.47406550617505 3.24220742398631e-11 0.990643124320291 1.17862667832619e-06 mirMAP -0.344656671453606 1.11915080146253e-10 24510775 miR 145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6; In our study paclitaxel-resistant ovarian cancer patients and cell lines had decreased miR-145 levels and expressed high levels of Sp1 and Cdk6; Furthermore we confirmed that both Cdk6 and Sp1 are targets of miR-145; Collectively these findings begin to elucidate the role of miR-145 as an important regulator of chemoresistance in ovarian cancer by controlling both Cdk6 and Sp1 drug resistance ovarian cancer hsa-miR-145-5p CDK6 -1.54503595327403 2.65080161523141e-09 0.990643124320291 1.17862667832619e-06 miRNATAP -0.290716781237802 2.77020181110234e-10 24510775 miR 145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6; In our study paclitaxel-resistant ovarian cancer patients and cell lines had decreased miR-145 levels and expressed high levels of Sp1 and Cdk6; Furthermore we confirmed that both Cdk6 and Sp1 are targets of miR-145; Collectively these findings begin to elucidate the role of miR-145 as an important regulator of chemoresistance in ovarian cancer by controlling both Cdk6 and Sp1 drug resistance ovarian cancer hsa-miR-195-5p CDK6 -1.07154705036962 4.16544134775761e-08 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase -0.290091435905514 3.96478737812371e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-26b-5p CDK6 -0.499493687076043 0.0118149973400486 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158657733610352 0.0134979371521054 NA NA NA hsa-miR-27b-3p CDK6 -0.439806942644624 0.000523870009254693 0.990643124320291 1.17862667832619e-06 mirMAP -0.252639297594135 0.0129354048194692 NA NA NA hsa-miR-29c-3p CDK6 -1.34143813218298 2.77493790306384e-12 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265226660289665 2.67195043466264e-05 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30a-3p CDK6 -1.27950866170419 4.33230022379782e-09 0.990643124320291 1.17862667832619e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.25961002788022 3.57594650212499e-06 NA NA NA hsa-miR-30a-5p CDK6 -0.742755040631906 3.79943871404435e-05 0.990643124320291 1.17862667832619e-06 mirMAP -0.245225033410941 0.000435613889393649 NA NA NA hsa-miR-30b-5p CDK6 -0.0106833209203501 0.954966272944722 0.990643124320291 1.17862667832619e-06 mirMAP -0.140953622170833 0.0380634742449815 NA NA NA hsa-miR-374b-5p CDK6 0.00249900187478502 0.985380083859555 0.990643124320291 1.17862667832619e-06 mirMAP -0.207264926074624 0.0297836165909739 NA NA NA hsa-miR-497-5p CDK6 -0.486115215577409 0.00973897247186318 0.990643124320291 1.17862667832619e-06 miRNATAP -0.239968806241616 0.000370608392551898 NA NA NA hsa-miR-9-5p CDK6 -0.887069929841985 0.00529865051479737 0.990643124320291 1.17862667832619e-06 mirMAP -0.142994009007753 0.000289625379889559 NA NA NA hsa-let-7a-5p CDKN1A 0.298659498236324 0.00963231738125113 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;MirTarget;TargetScan -0.35986665527898 0.000385524311347491 NA NA NA hsa-let-7e-5p CDKN1A 0.227253058773149 0.162290058199053 -1.26866697234787 1.6534116759688e-12 MirTarget -0.183435616986943 0.0101870597831225 NA NA NA hsa-let-7f-5p CDKN1A 0.300925310468863 0.0221019558342241 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;MirTarget -0.246997976543877 0.00538611588830313 NA NA NA hsa-let-7i-5p CDKN1A 0.90895826823783 5.79676789748755e-17 -1.26866697234787 1.6534116759688e-12 MirTarget -0.394236057392729 0.000101892575632853 NA NA NA hsa-miR-106a-5p CDKN1A 0.587427028487119 0.00838999163993323 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.173640322178151 0.000693869591447925 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-146b-5p CDKN1A 2.23105707690238 3.83997814011313e-23 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate -0.215180106045082 3.12241828598735e-06 27602131 During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis progression thyroid cancer hsa-miR-17-5p CDKN1A 1.57209612312313 5.10453838016207e-11 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.191048011916783 2.99245686343416e-05 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-20a-5p CDKN1A 1.57190995476158 8.72275528729458e-12 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.291264058902903 3.74080074414107e-10 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-423-3p CDKN1A 1.0646553568956 2.48410617381049e-08 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase -0.123274678075497 0.0366109991451148 NA NA NA hsa-miR-423-5p CDKN1A 0.554579912507932 7.65114789083517e-05 -1.26866697234787 1.6534116759688e-12 MirTarget -0.17798518970221 0.0306931514275593 NA NA NA hsa-miR-93-5p CDKN1A 1.68243825551104 4.62947431501061e-15 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.270597575279336 5.19228546193252e-08 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-98-5p CDKN1A 0.72508924193932 6.07191196761022e-10 -1.26866697234787 1.6534116759688e-12 miRNAWalker2_validate;MirTarget -0.235995727619112 0.0152793429006797 NA NA NA hsa-miR-140-5p CDKN1B 0.132398579631585 0.457960134430787 -0.0847508653944109 0.424643882738365 miRanda -0.120359491504028 0.000933066953674841 NA NA NA hsa-miR-221-3p CDKN1B 1.11809809289021 6.56903442847056e-08 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.130595918572421 1.50281798728683e-05 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.50650995841483 1.51287294049382e-09 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.112013615016007 6.06815852683629e-06 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-24-3p CDKN1B 0.425646348491286 0.00136678638934554 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate;miRNATAP -0.321808040925846 1.03857558435644e-11 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-30e-3p CDKN1B -0.444998679251398 0.000501880465265124 -0.0847508653944109 0.424643882738365 MirTarget -0.149276785408705 0.00340664023322551 NA NA NA hsa-miR-505-3p CDKN1B 0.68973424635459 0.00225185811813183 -0.0847508653944109 0.424643882738365 MirTarget -0.119637739674627 2.132964534306e-05 NA NA NA hsa-miR-98-5p CDKN1B 0.72508924193932 6.07191196761022e-10 -0.0847508653944109 0.424643882738365 miRNAWalker2_validate -0.174172818189207 0.00137872817304278 NA NA NA hsa-miR-107 CHAD 0.85152957824299 1.22369651446858e-11 -2.48111367131906 4.27739856042192e-15 miRanda -0.544005532595798 0.000616450516372901 NA NA NA hsa-miR-199a-3p CHAD 1.04459501900922 2.43330173715104e-11 -2.48111367131906 4.27739856042192e-15 MirTarget;miRNATAP -0.394052611221621 0.00187900269074759 NA NA NA hsa-miR-199b-3p CHAD 1.04524477057703 2.47846951108535e-11 -2.48111367131906 4.27739856042192e-15 MirTarget -0.392963529300179 0.00191429787279695 NA NA NA hsa-miR-222-5p CHAD 1.40730191326147 1.77506391601374e-06 -2.48111367131906 4.27739856042192e-15 MirTarget -0.170647658817368 0.0135451831367835 NA NA NA hsa-miR-493-3p CHAD 1.47683781636643 8.06811473387944e-13 -2.48111367131906 4.27739856042192e-15 MirTarget -0.278291031435002 0.00398082174051912 NA NA NA hsa-miR-103a-3p CHRM1 1.01322687786547 1.60813894223583e-11 -2.21044228064953 1.09521656906182e-05 miRNATAP -0.516034051311905 0.010803702188361 NA NA NA hsa-miR-107 CHRM1 0.85152957824299 1.22369651446858e-11 -2.21044228064953 1.09521656906182e-05 miRNAWalker2_validate;PITA;miRNATAP -0.594777133166722 0.0149252780474617 NA NA NA hsa-miR-185-3p CHRM1 1.38509197368746 3.93425296894499e-10 -2.21044228064953 1.09521656906182e-05 MirTarget;mirMAP -0.329129571142965 0.0202182435295342 NA NA NA hsa-miR-27a-3p CHRM1 0.523219911315699 0.000116410279757859 -2.21044228064953 1.09521656906182e-05 miRNATAP -0.676206942921123 0.00348040219091253 NA NA NA hsa-miR-10b-3p CHRM2 0.448860145188521 0.00703361939318676 -2.8543543155898 6.2964660060643e-05 mirMAP -1.35398452029942 2.56527015954631e-07 NA NA NA hsa-miR-126-5p CHRM2 0.450893496822779 0.0112966412858755 -2.8543543155898 6.2964660060643e-05 mirMAP -1.36910285055877 1.98184515671868e-08 NA NA NA hsa-miR-142-5p CHRM2 1.08445947321046 0.000126372881543671 -2.8543543155898 6.2964660060643e-05 mirMAP -0.919438617834033 9.02980899083063e-10 NA NA NA hsa-miR-16-1-3p CHRM2 1.23864765632542 1.24544799589822e-08 -2.8543543155898 6.2964660060643e-05 mirMAP -1.91370548959582 1.49939596072937e-24 NA NA NA hsa-miR-17-5p CHRM2 1.57209612312313 5.10453838016207e-11 -2.8543543155898 6.2964660060643e-05 TargetScan -1.89376512478551 2.06098069842487e-33 NA NA NA hsa-miR-186-5p CHRM2 0.35512789129261 0.0196931838168008 -2.8543543155898 6.2964660060643e-05 mirMAP -2.42623351343775 1.08013384931229e-18 NA NA NA hsa-miR-26a-2-3p CHRM2 0.0619487388777404 0.765401751442771 -2.8543543155898 6.2964660060643e-05 mirMAP -0.652415609683586 0.00268550107847328 NA NA NA hsa-miR-29b-1-5p CHRM2 1.27585983480192 1.70509960024426e-05 -2.8543543155898 6.2964660060643e-05 mirMAP -1.20495967983798 3.32134155259063e-18 NA NA NA hsa-miR-335-3p CHRM2 2.29463721765513 4.1956113745077e-18 -2.8543543155898 6.2964660060643e-05 mirMAP -1.21099998222613 2.64659940272912e-16 NA NA NA hsa-miR-335-5p CHRM2 0.576542642348884 0.01886326850059 -2.8543543155898 6.2964660060643e-05 miRNAWalker2_validate -1.12477268771115 1.26407813384838e-10 NA NA NA hsa-miR-409-3p CHRM2 1.02296003511803 1.54748197930307e-08 -2.8543543155898 6.2964660060643e-05 mirMAP -1.18072899908723 5.38834023283763e-07 NA NA NA hsa-miR-429 CHRM2 1.58250682050303 4.75828087352234e-05 -2.8543543155898 6.2964660060643e-05 miRanda -1.06006640242172 1.83131440259383e-24 NA NA NA hsa-miR-501-5p CHRM2 1.59306197632625 2.04856600619363e-09 -2.8543543155898 6.2964660060643e-05 mirMAP -1.3451107533142 3.25166009937555e-17 NA NA NA hsa-miR-542-3p CHRM2 1.12416854979951 1.02649534578738e-12 -2.8543543155898 6.2964660060643e-05 miRanda -1.42884439587068 7.43165561356244e-08 NA NA NA hsa-miR-577 CHRM2 0.615893340074725 0.210494450869356 -2.8543543155898 6.2964660060643e-05 mirMAP -0.549979053211106 8.57548949022724e-09 NA NA NA hsa-miR-590-3p CHRM2 0.858742926831233 0.000127281269371976 -2.8543543155898 6.2964660060643e-05 mirMAP -1.73707305582006 9.47649726904109e-22 NA NA NA hsa-miR-664a-3p CHRM2 -0.0290482945770787 0.844010225386475 -2.8543543155898 6.2964660060643e-05 mirMAP -0.971598072776308 0.00138550409270471 NA NA NA hsa-miR-152-3p CHUK -0.111001946024117 0.385698870309139 0.260508655820102 0.00541846716349918 MirTarget -0.232227140209855 2.32379778653902e-07 NA NA NA hsa-miR-195-5p CHUK -1.07154705036962 4.16544134775761e-08 0.260508655820102 0.00541846716349918 miRNAWalker2_validate;MirTarget -0.209408932879662 1.77454617069446e-14 NA NA NA hsa-miR-23b-3p CHUK -0.228571473429 0.0553601132069074 0.260508655820102 0.00541846716349918 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.10524484472265 0.0326504816656031 NA NA NA hsa-miR-497-5p CHUK -0.486115215577409 0.00973897247186318 0.260508655820102 0.00541846716349918 MirTarget -0.203365591669603 4.10879523802409e-12 NA NA NA hsa-miR-129-5p COL1A1 -1.61803714443871 4.93214379865694e-06 3.01832941044284 9.17776951829232e-25 miRanda -0.198152791531569 0.000347532196612993 NA NA NA hsa-miR-133a-3p COL1A1 -2.63342156915404 5.72661351480585e-12 3.01832941044284 9.17776951829232e-25 miRNAWalker2_validate -0.147252420806544 0.00287134050361538 NA NA NA hsa-miR-29a-3p COL1A1 -0.235052170104117 0.138527567930958 3.01832941044284 9.17776951829232e-25 miRNATAP -0.277352756228887 0.0280100582819019 NA NA NA hsa-miR-29c-3p COL1A1 -1.34143813218298 2.77493790306384e-12 3.01832941044284 9.17776951829232e-25 miRNAWalker2_validate;miRTarBase;miRNATAP -0.670609552371574 1.89824334137737e-12 NA NA NA hsa-miR-30a-3p COL1A1 -1.27950866170419 4.33230022379782e-09 3.01832941044284 9.17776951829232e-25 mirMAP -0.275462375964194 0.00174400589682348 NA NA NA hsa-miR-30d-3p COL1A1 0.0608340295673737 0.708110230223927 3.01832941044284 9.17776951829232e-25 mirMAP -0.356231819282311 0.00377663522388148 NA NA NA hsa-miR-30e-3p COL1A1 -0.444998679251398 0.000501880465265124 3.01832941044284 9.17776951829232e-25 mirMAP -0.382792669838968 0.014463689796112 NA NA NA hsa-let-7g-5p COL1A2 0.296128761926282 0.0296823495976068 1.99129889840057 1.91910875124574e-15 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.314202048102525 0.00943250640286477 NA NA NA hsa-miR-129-5p COL1A2 -1.61803714443871 4.93214379865694e-06 1.99129889840057 1.91910875124574e-15 miRanda -0.123765409389322 0.00678267741669448 NA NA NA hsa-miR-19b-3p COL1A2 0.936987029203338 9.28141970787798e-06 1.99129889840057 1.91910875124574e-15 MirTarget -0.15800617563689 0.0375143169056359 NA NA NA hsa-miR-26a-5p COL1A2 -0.507487084157331 3.23715933371269e-05 1.99129889840057 1.91910875124574e-15 MirTarget;miRNATAP -0.438968164152283 0.00102337301616581 NA NA NA hsa-miR-26b-5p COL1A2 -0.499493687076043 0.0118149973400486 1.99129889840057 1.91910875124574e-15 MirTarget;miRNATAP -0.262163857804152 0.00131243549913771 NA NA NA hsa-miR-29a-3p COL1A2 -0.235052170104117 0.138527567930958 1.99129889840057 1.91910875124574e-15 miRNATAP -0.335453116244536 0.00113547509593049 NA NA NA hsa-miR-29b-3p COL1A2 0.0225365195743876 0.914313337784307 1.99129889840057 1.91910875124574e-15 miRNATAP -0.264394849152797 0.000652389484852107 NA NA NA hsa-miR-29c-3p COL1A2 -1.34143813218298 2.77493790306384e-12 1.99129889840057 1.91910875124574e-15 miRNAWalker2_validate;miRTarBase;miRNATAP -0.526317145423807 2.0444889405624e-11 NA NA NA hsa-miR-30d-3p COL1A2 0.0608340295673737 0.708110230223927 1.99129889840057 1.91910875124574e-15 MirTarget -0.433499235204542 1.45513980023703e-05 NA NA NA hsa-miR-30e-3p COL1A2 -0.444998679251398 0.000501880465265124 1.99129889840057 1.91910875124574e-15 MirTarget -0.347672036578724 0.00674886427838729 NA NA NA hsa-miR-32-5p COL1A2 0.425717775201634 0.0402079308210921 1.99129889840057 1.91910875124574e-15 MirTarget;miRNATAP -0.29242848563087 0.000171039667609311 NA NA NA hsa-miR-33a-3p COL1A2 0.21453033253985 0.371591474252951 1.99129889840057 1.91910875124574e-15 MirTarget -0.170379101445688 0.0162946398724793 NA NA NA hsa-miR-7-5p COL1A2 1.20202447072014 0.000123775346787165 1.99129889840057 1.91910875124574e-15 miRNATAP -0.108472488619257 0.0477566793334595 NA NA NA hsa-let-7a-3p COL4A1 0.283468597868531 0.127007787220086 1.78756439655909 1.15160259120415e-19 miRNATAP -0.263391696042605 0.000160453752247623 NA NA NA hsa-let-7g-5p COL4A1 0.296128761926282 0.0296823495976068 1.78756439655909 1.15160259120415e-19 miRNATAP -0.297612953601766 0.00204309330827136 NA NA NA hsa-miR-148a-3p COL4A1 -0.18108394434325 0.495345303586758 1.78756439655909 1.15160259120415e-19 miRNATAP -0.254465354561005 1.10309751729326e-07 NA NA NA hsa-miR-16-5p COL4A1 0.468459442059375 0.02635007201346 1.78756439655909 1.15160259120415e-19 miRNAWalker2_validate -0.154435330020513 0.0121553308385016 NA NA NA hsa-miR-193b-3p COL4A1 -0.0325435210716751 0.883410452152887 1.78756439655909 1.15160259120415e-19 miRNAWalker2_validate -0.12076002870032 0.0402232151529972 NA NA NA hsa-miR-29a-3p COL4A1 -0.235052170104117 0.138527567930958 1.78756439655909 1.15160259120415e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.408935283764736 4.84697029854186e-07 NA NA NA hsa-miR-29b-3p COL4A1 0.0225365195743876 0.914313337784307 1.78756439655909 1.15160259120415e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.318358519720346 1.88924471659887e-07 NA NA NA hsa-miR-29c-3p COL4A1 -1.34143813218298 2.77493790306384e-12 1.78756439655909 1.15160259120415e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.466603589817894 5.80195759024876e-14 NA NA NA hsa-miR-429 COL4A1 1.58250682050303 4.75828087352234e-05 1.78756439655909 1.15160259120415e-19 miRanda;miRNATAP -0.107769057488019 0.00115567729765916 NA NA NA hsa-miR-590-3p COL4A1 0.858742926831233 0.000127281269371976 1.78756439655909 1.15160259120415e-19 miRanda -0.175610712946079 0.00218498959536211 NA NA NA hsa-let-7g-5p COL4A2 0.296128761926282 0.0296823495976068 1.02334447820144 1.14936313463397e-07 miRNATAP -0.488682504617918 3.0140434747626e-08 NA NA NA hsa-miR-1266-5p COL4A2 0.979589775323276 0.00202750169930305 1.02334447820144 1.14936313463397e-07 MirTarget -0.206719470274512 2.10447967750485e-08 NA NA NA hsa-miR-155-5p COL4A2 0.708423342476697 0.00686702252429413 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate -0.198213179651833 1.26181960726801e-05 NA NA NA hsa-miR-16-5p COL4A2 0.468459442059375 0.02635007201346 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate -0.282823841850533 5.33266269478467e-07 NA NA NA hsa-miR-26b-5p COL4A2 -0.499493687076043 0.0118149973400486 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate -0.3120200033126 1.85800604410395e-07 NA NA NA hsa-miR-29a-3p COL4A2 -0.235052170104117 0.138527567930958 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.412157499360549 4.67855098287002e-08 NA NA NA hsa-miR-29b-3p COL4A2 0.0225365195743876 0.914313337784307 1.02334447820144 1.14936313463397e-07 miRTarBase;MirTarget;miRNATAP -0.373753727157334 2.61205899750846e-11 NA NA NA hsa-miR-29c-3p COL4A2 -1.34143813218298 2.77493790306384e-12 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320819644751837 6.58990183656576e-08 NA NA NA hsa-miR-92a-3p COL4A2 1.06124545165614 6.51550014372282e-08 1.02334447820144 1.14936313463397e-07 miRNAWalker2_validate -0.237506794953439 7.205672849877e-05 NA NA NA hsa-miR-106a-5p COL4A3 0.587427028487119 0.00838999163993323 -0.748410740217012 0.0361489474679936 MirTarget;miRNATAP -0.436154732143059 6.76331762021214e-06 NA NA NA hsa-miR-106b-5p COL4A3 1.08518388423396 4.82746923373852e-09 -0.748410740217012 0.0361489474679936 MirTarget;miRNATAP -0.776690480496232 2.57406769357332e-12 NA NA NA hsa-miR-107 COL4A3 0.85152957824299 1.22369651446858e-11 -0.748410740217012 0.0361489474679936 miRanda -0.863867982865482 2.66499189121301e-07 NA NA NA hsa-miR-126-5p COL4A3 0.450893496822779 0.0112966412858755 -0.748410740217012 0.0361489474679936 mirMAP -0.472378343837801 0.000117506235000158 NA NA NA hsa-miR-135b-5p COL4A3 2.80066701698235 2.12546333413447e-11 -0.748410740217012 0.0361489474679936 MirTarget -0.370327117394683 1.8806306612024e-13 NA NA NA hsa-miR-140-5p COL4A3 0.132398579631585 0.457960134430787 -0.748410740217012 0.0361489474679936 miRanda -0.335853981400329 0.00672866826204371 NA NA NA hsa-miR-146b-5p COL4A3 2.23105707690238 3.83997814011313e-23 -0.748410740217012 0.0361489474679936 miRanda -0.208613389161202 0.0196913213132532 NA NA NA hsa-miR-15b-3p COL4A3 0.811179945491507 0.000927520880593552 -0.748410740217012 0.0361489474679936 mirMAP -0.632420482180617 9.15699901914886e-14 NA NA NA hsa-miR-16-2-3p COL4A3 0.869267463341732 0.000785361809327569 -0.748410740217012 0.0361489474679936 mirMAP -0.465849565167738 1.31339678913631e-08 NA NA NA hsa-miR-17-5p COL4A3 1.57209612312313 5.10453838016207e-11 -0.748410740217012 0.0361489474679936 MirTarget;TargetScan;miRNATAP -0.648545373927998 1.15608537190107e-14 NA NA NA hsa-miR-186-5p COL4A3 0.35512789129261 0.0196931838168008 -0.748410740217012 0.0361489474679936 mirMAP -0.79569468256913 2.12098428646012e-08 NA NA NA hsa-miR-193a-3p COL4A3 0.148284355948959 0.379093889907371 -0.748410740217012 0.0361489474679936 miRanda -0.329916094671409 0.0120896806192333 NA NA NA hsa-miR-200b-3p COL4A3 2.06025765178663 3.07718049337497e-10 -0.748410740217012 0.0361489474679936 TargetScan -0.329085070334415 2.00627160069928e-07 NA NA NA hsa-miR-200c-3p COL4A3 1.74925752003763 3.42000026705311e-08 -0.748410740217012 0.0361489474679936 miRNATAP -0.428649376475561 4.0359718300153e-11 NA NA NA hsa-miR-20a-5p COL4A3 1.57190995476158 8.72275528729458e-12 -0.748410740217012 0.0361489474679936 MirTarget;miRNATAP -0.503323054394377 1.77862781559596e-08 NA NA NA hsa-miR-2110 COL4A3 0.359318473683641 0.126104910543249 -0.748410740217012 0.0361489474679936 MirTarget -0.41578495354114 2.20521432637501e-05 NA NA NA hsa-miR-26b-5p COL4A3 -0.499493687076043 0.0118149973400486 -0.748410740217012 0.0361489474679936 mirMAP -0.3769095516613 0.000615137818480734 NA NA NA hsa-miR-29a-5p COL4A3 1.00715634051951 4.47499137997344e-07 -0.748410740217012 0.0361489474679936 mirMAP -0.502441423266373 2.32859160328235e-06 NA NA NA hsa-miR-29b-3p COL4A3 0.0225365195743876 0.914313337784307 -0.748410740217012 0.0361489474679936 MirTarget;miRNATAP -0.338245290771075 0.00125935452928025 NA NA NA hsa-miR-30d-3p COL4A3 0.0608340295673737 0.708110230223927 -0.748410740217012 0.0361489474679936 MirTarget -0.580831799587332 1.71184260391553e-05 NA NA NA hsa-miR-326 COL4A3 -0.552187708067123 0.039648668341622 -0.748410740217012 0.0361489474679936 miRanda -0.335207422010538 3.37648977733139e-05 NA NA NA hsa-miR-330-3p COL4A3 0.391166748754241 0.0581284813543685 -0.748410740217012 0.0361489474679936 miRNATAP -0.293030422101441 0.00777566022981471 NA NA NA hsa-miR-330-5p COL4A3 0.621676971901542 0.00233177378595631 -0.748410740217012 0.0361489474679936 miRanda -0.445544718225431 2.61244580872229e-05 NA NA NA hsa-miR-335-3p COL4A3 2.29463721765513 4.1956113745077e-18 -0.748410740217012 0.0361489474679936 mirMAP -0.507973829445841 9.97746150270602e-12 NA NA NA hsa-miR-33a-3p COL4A3 0.21453033253985 0.371591474252951 -0.748410740217012 0.0361489474679936 MirTarget -0.465302765859528 7.66939334301003e-07 NA NA NA hsa-miR-3607-3p COL4A3 0.479939234340415 0.251616873367277 -0.748410740217012 0.0361489474679936 miRNATAP -0.20530375781559 0.000121977451353559 NA NA NA hsa-miR-370-3p COL4A3 0.890678459183993 3.22718457503803e-05 -0.748410740217012 0.0361489474679936 MirTarget -0.392059213781983 0.000100331699059675 NA NA NA hsa-miR-429 COL4A3 1.58250682050303 4.75828087352234e-05 -0.748410740217012 0.0361489474679936 miRanda;miRNATAP -0.338354381013047 5.69581855836142e-10 NA NA NA hsa-miR-501-3p COL4A3 1.88467797720099 9.65178855450719e-15 -0.748410740217012 0.0361489474679936 miRNATAP -0.55745421199519 1.44971279874692e-11 NA NA NA hsa-miR-502-3p COL4A3 0.989057260587538 3.37032335853725e-07 -0.748410740217012 0.0361489474679936 miRNATAP -0.651641859240083 1.6483231312227e-09 NA NA NA hsa-miR-539-5p COL4A3 0.455406484803261 0.10846447950775 -0.748410740217012 0.0361489474679936 MirTarget -0.249352105186515 0.00144145171186746 NA NA NA hsa-miR-542-3p COL4A3 1.12416854979951 1.02649534578738e-12 -0.748410740217012 0.0361489474679936 miRanda -0.303158276735769 0.0241673798131857 NA NA NA hsa-miR-590-3p COL4A3 0.858742926831233 0.000127281269371976 -0.748410740217012 0.0361489474679936 miRanda -0.481356914444004 4.49582259166938e-07 NA NA NA hsa-miR-625-5p COL4A3 0.748754910408313 0.00783938428700196 -0.748410740217012 0.0361489474679936 MirTarget -0.533174849598182 1.63998434206145e-12 NA NA NA hsa-miR-7-1-3p COL4A3 0.94398354303717 7.5771319809992e-05 -0.748410740217012 0.0361489474679936 MirTarget -0.656254151834542 3.62685632885994e-14 NA NA NA hsa-miR-93-3p COL4A3 1.18510939268904 1.19856269043125e-06 -0.748410740217012 0.0361489474679936 miRNATAP -0.671257213289709 8.88976740076611e-16 NA NA NA hsa-miR-93-5p COL4A3 1.68243825551104 4.62947431501061e-15 -0.748410740217012 0.0361489474679936 MirTarget;miRNATAP -0.611994777363294 6.56974321461571e-11 NA NA NA hsa-let-7a-3p COL4A4 0.283468597868531 0.127007787220086 0.203566165779439 0.562717703881247 mirMAP -0.382079541798783 0.000989995244575737 NA NA NA hsa-let-7b-3p COL4A4 0.377956364821509 0.0061730103051373 0.203566165779439 0.562717703881247 mirMAP -0.625453820255869 6.3016847701689e-05 NA NA NA hsa-let-7f-1-3p COL4A4 1.09636075438131 3.42037366931931e-10 0.203566165779439 0.562717703881247 mirMAP -0.688132984643739 3.73563090491284e-09 NA NA NA hsa-miR-107 COL4A4 0.85152957824299 1.22369651446858e-11 0.203566165779439 0.562717703881247 miRanda -0.762686603988751 4.04387378151968e-06 NA NA NA hsa-miR-130b-3p COL4A4 1.29757792612022 1.70655148591568e-06 0.203566165779439 0.562717703881247 mirMAP -0.431647908293406 1.27320543540409e-08 NA NA NA hsa-miR-15b-3p COL4A4 0.811179945491507 0.000927520880593552 0.203566165779439 0.562717703881247 MirTarget -0.443699602231865 2.0887265050966e-07 NA NA NA hsa-miR-16-5p COL4A4 0.468459442059375 0.02635007201346 0.203566165779439 0.562717703881247 mirMAP -0.439780736121142 1.2927402552007e-05 NA NA NA hsa-miR-182-5p COL4A4 1.73826081735237 5.69817940588551e-09 0.203566165779439 0.562717703881247 MirTarget -0.360954093022012 1.34746010050489e-07 NA NA NA hsa-miR-186-5p COL4A4 0.35512789129261 0.0196931838168008 0.203566165779439 0.562717703881247 mirMAP -0.557334231034693 8.1019757912611e-05 NA NA NA hsa-miR-203a-3p COL4A4 0.986535065247669 0.00954714606545506 0.203566165779439 0.562717703881247 MirTarget -0.313386343722367 9.94758441811186e-09 NA NA NA hsa-miR-2110 COL4A4 0.359318473683641 0.126104910543249 0.203566165779439 0.562717703881247 miRNATAP -0.33969217260536 0.000438945869193612 NA NA NA hsa-miR-23a-3p COL4A4 0.694558223570443 8.99413995422816e-10 0.203566165779439 0.562717703881247 miRNATAP -0.540546208212828 0.0041090639122056 NA NA NA hsa-miR-26b-5p COL4A4 -0.499493687076043 0.0118149973400486 0.203566165779439 0.562717703881247 miRNAWalker2_validate -0.301123902756672 0.0054505508887653 NA NA NA hsa-miR-299-5p COL4A4 -0.162422032147768 0.435278723340297 0.203566165779439 0.562717703881247 miRNATAP -0.261136348829226 0.0126897221564532 NA NA NA hsa-miR-29a-3p COL4A4 -0.235052170104117 0.138527567930958 0.203566165779439 0.562717703881247 MirTarget;miRNATAP -0.271597249075847 0.0480960135436683 NA NA NA hsa-miR-29b-3p COL4A4 0.0225365195743876 0.914313337784307 0.203566165779439 0.562717703881247 MirTarget;miRNATAP -0.358359980949565 0.000483916075092866 NA NA NA hsa-miR-301a-3p COL4A4 1.22580753116505 5.84016077664577e-09 0.203566165779439 0.562717703881247 mirMAP -0.268722114178215 0.00685964200194575 NA NA NA hsa-miR-30d-3p COL4A4 0.0608340295673737 0.708110230223927 0.203566165779439 0.562717703881247 MirTarget -0.483670918737954 0.000281150068208893 NA NA NA hsa-miR-33a-3p COL4A4 0.21453033253985 0.371591474252951 0.203566165779439 0.562717703881247 mirMAP -0.404960295678477 1.27464291727221e-05 NA NA NA hsa-miR-361-5p COL4A4 0.538048008019709 1.61165802415302e-07 0.203566165779439 0.562717703881247 MirTarget;miRanda -0.620460092764563 0.0033663345798175 NA NA NA hsa-miR-429 COL4A4 1.58250682050303 4.75828087352234e-05 0.203566165779439 0.562717703881247 miRNATAP -0.251134901469172 3.90715795784979e-06 NA NA NA hsa-miR-454-3p COL4A4 0.823770738595667 1.30339728183332e-05 0.203566165779439 0.562717703881247 mirMAP -0.365343233725466 0.00113363449415647 NA NA NA hsa-miR-501-5p COL4A4 1.59306197632625 2.04856600619363e-09 0.203566165779439 0.562717703881247 mirMAP -0.355553657975674 1.20474861739602e-05 NA NA NA hsa-miR-532-3p COL4A4 1.35968112631236 2.41509711096659e-06 0.203566165779439 0.562717703881247 miRNATAP -0.383951084314449 8.11868460332421e-08 NA NA NA hsa-miR-576-5p COL4A4 0.872721964495849 5.20470410008775e-05 0.203566165779439 0.562717703881247 PITA -0.540218775868764 2.08218814337837e-08 NA NA NA hsa-miR-577 COL4A4 0.615893340074725 0.210494450869356 0.203566165779439 0.562717703881247 mirMAP -0.203269120350139 1.54272777607255e-05 NA NA NA hsa-miR-589-3p COL4A4 1.00357906465313 8.20399071001461e-05 0.203566165779439 0.562717703881247 mirMAP -0.540976565648051 2.24097769664256e-10 NA NA NA hsa-miR-590-3p COL4A4 0.858742926831233 0.000127281269371976 0.203566165779439 0.562717703881247 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.348178377316805 0.000233044597889581 NA NA NA hsa-miR-629-3p COL4A4 0.597278340934362 0.0508108703940013 0.203566165779439 0.562717703881247 MirTarget;miRNATAP -0.323834404685425 1.28304156696496e-05 NA NA NA hsa-let-7a-5p COL4A5 0.298659498236324 0.00963231738125113 -2.08399438260746 6.69765955151689e-08 TargetScan;miRNATAP -0.687089032366812 0.00135760398820753 NA NA NA hsa-let-7b-5p COL4A5 0.16896311055967 0.160596228583843 -2.08399438260746 6.69765955151689e-08 miRNATAP -0.549633902383652 0.0077607084247152 NA NA NA hsa-let-7f-5p COL4A5 0.300925310468863 0.0221019558342241 -2.08399438260746 6.69765955151689e-08 miRNATAP -0.680767556125043 0.000259367160548482 NA NA NA hsa-let-7g-5p COL4A5 0.296128761926282 0.0296823495976068 -2.08399438260746 6.69765955151689e-08 miRNATAP -1.29407994044534 6.61705759515471e-14 NA NA NA hsa-let-7i-5p COL4A5 0.90895826823783 5.79676789748755e-17 -2.08399438260746 6.69765955151689e-08 miRNATAP -1.46157022199563 1.80883609037614e-12 NA NA NA hsa-miR-146b-5p COL4A5 2.23105707690238 3.83997814011313e-23 -2.08399438260746 6.69765955151689e-08 miRanda -0.828513344826996 2.74456779515583e-19 NA NA NA hsa-miR-193a-3p COL4A5 0.148284355948959 0.379093889907371 -2.08399438260746 6.69765955151689e-08 miRanda -0.341702068773535 0.018862058198267 NA NA NA hsa-miR-199b-3p COL4A5 1.04524477057703 2.47846951108535e-11 -2.08399438260746 6.69765955151689e-08 miRNATAP -0.477466147553768 0.00145725901566851 NA NA NA hsa-miR-23a-3p COL4A5 0.694558223570443 8.99413995422816e-10 -2.08399438260746 6.69765955151689e-08 miRNATAP -1.27547065298044 6.58717991450206e-10 NA NA NA hsa-miR-26b-5p COL4A5 -0.499493687076043 0.0118149973400486 -2.08399438260746 6.69765955151689e-08 miRNAWalker2_validate -0.286468618725038 0.0193049062928642 NA NA NA hsa-miR-29a-3p COL4A5 -0.235052170104117 0.138527567930958 -2.08399438260746 6.69765955151689e-08 miRNATAP -0.607376281411177 7.37591123278431e-05 NA NA NA hsa-miR-29b-3p COL4A5 0.0225365195743876 0.914313337784307 -2.08399438260746 6.69765955151689e-08 miRNATAP -0.639304443848319 1.88529737999181e-08 NA NA NA hsa-miR-330-3p COL4A5 0.391166748754241 0.0581284813543685 -2.08399438260746 6.69765955151689e-08 PITA -0.537072037683874 8.02489686498223e-06 NA NA NA hsa-miR-335-5p COL4A5 0.576542642348884 0.01886326850059 -2.08399438260746 6.69765955151689e-08 miRNAWalker2_validate -0.318754208587281 0.00122312273056088 NA NA NA hsa-miR-338-5p COL4A5 -0.420442436641152 0.0583175290447746 -2.08399438260746 6.69765955151689e-08 PITA;miRNATAP -0.270739958919461 0.0134954343368447 NA NA NA hsa-miR-429 COL4A5 1.58250682050303 4.75828087352234e-05 -2.08399438260746 6.69765955151689e-08 miRanda -0.4331416256234 3.57089569482513e-13 NA NA NA hsa-miR-455-5p COL4A5 0.644390760445571 0.00262275997170695 -2.08399438260746 6.69765955151689e-08 miRanda -0.338483487796503 0.00263958130499775 NA NA NA hsa-miR-590-3p COL4A5 0.858742926831233 0.000127281269371976 -2.08399438260746 6.69765955151689e-08 miRanda;mirMAP -0.76741340796196 7.23612035993539e-14 NA NA NA hsa-let-7a-5p COL4A6 0.298659498236324 0.00963231738125113 -3.1824285822787 2.48042514619481e-11 TargetScan -0.984920559308059 0.000237183947696116 NA NA NA hsa-miR-197-3p COL4A6 0.540951726189935 0.00440139185360704 -3.1824285822787 2.48042514619481e-11 miRNAWalker2_validate -1.19957307092616 2.84704218315114e-15 NA NA NA hsa-miR-29a-3p COL4A6 -0.235052170104117 0.138527567930958 -3.1824285822787 2.48042514619481e-11 miRNATAP -0.502809644523628 0.00942125601703859 NA NA NA hsa-miR-29b-3p COL4A6 0.0225365195743876 0.914313337784307 -3.1824285822787 2.48042514619481e-11 miRNATAP -0.726607332758197 3.95624242769831e-07 NA NA NA hsa-miR-326 COL4A6 -0.552187708067123 0.039648668341622 -3.1824285822787 2.48042514619481e-11 miRanda -0.263125364504645 0.0202205936081372 NA NA NA hsa-miR-330-5p COL4A6 0.621676971901542 0.00233177378595631 -3.1824285822787 2.48042514619481e-11 miRanda -0.936057770589876 6.86670607084082e-11 NA NA NA hsa-miR-342-3p COL4A6 0.235422340773149 0.290471946350276 -3.1824285822787 2.48042514619481e-11 miRanda -0.350062411369753 0.0105572514422368 NA NA NA hsa-miR-429 COL4A6 1.58250682050303 4.75828087352234e-05 -3.1824285822787 2.48042514619481e-11 miRanda;miRNATAP -0.609230643150643 1.24420560774118e-16 NA NA NA hsa-miR-582-3p COL4A6 -0.104548775434833 0.640423116430294 -3.1824285822787 2.48042514619481e-11 PITA -0.314319344965844 0.0212810291594504 NA NA NA hsa-miR-590-3p COL4A6 0.858742926831233 0.000127281269371976 -3.1824285822787 2.48042514619481e-11 miRanda -1.037626939041 3.57798346125892e-16 NA NA NA hsa-miR-96-5p COL4A6 1.44821155854693 6.56312590328933e-06 -3.1824285822787 2.48042514619481e-11 TargetScan -0.772649225868063 1.35611109200739e-16 NA NA NA hsa-miR-324-5p COL6A1 0.800946351685734 0.00101337664367375 0.31753336955795 0.110218030169359 miRNAWalker2_validate -0.173885886002399 0.000418466451823052 NA NA NA hsa-miR-335-5p COL6A1 0.576542642348884 0.01886326850059 0.31753336955795 0.110218030169359 miRNAWalker2_validate -0.191272594349385 0.000102665607345738 NA NA NA hsa-miR-29a-3p COL6A3 -0.235052170104117 0.138527567930958 1.53022847231736 5.19219979969388e-11 MirTarget;miRNATAP -0.463462250440403 5.98803746684465e-07 NA NA NA hsa-miR-29b-3p COL6A3 0.0225365195743876 0.914313337784307 1.53022847231736 5.19219979969388e-11 MirTarget;miRNATAP -0.379627403589775 4.96330491344111e-08 NA NA NA hsa-miR-29c-3p COL6A3 -1.34143813218298 2.77493790306384e-12 1.53022847231736 5.19219979969388e-11 MirTarget;miRNATAP -0.44151173803616 9.63893807116597e-10 NA NA NA hsa-miR-330-3p COL6A3 0.391166748754241 0.0581284813543685 1.53022847231736 5.19219979969388e-11 miRNATAP -0.224196271849337 0.0025430255339522 NA NA NA hsa-miR-362-3p COL6A3 0.994614346444282 4.39793878186399e-05 1.53022847231736 5.19219979969388e-11 miRanda -0.288158176324949 2.54913709890652e-06 NA NA NA hsa-miR-429 COL6A3 1.58250682050303 4.75828087352234e-05 1.53022847231736 5.19219979969388e-11 miRNATAP -0.194343107925408 1.87194588931017e-07 NA NA NA hsa-miR-590-3p COL6A3 0.858742926831233 0.000127281269371976 1.53022847231736 5.19219979969388e-11 miRanda -0.31407966574572 1.15794657068296e-06 NA NA NA hsa-miR-335-5p COL6A5 0.576542642348884 0.01886326850059 -1.19470613214777 0.00190550349013069 miRNAWalker2_validate -0.191999022436504 0.048021911953028 NA NA NA hsa-miR-30a-3p COL6A6 -1.27950866170419 4.33230022379782e-09 1.04670724495871 0.00315333354883248 mirMAP -0.205648634665777 0.0353561596434848 NA NA NA hsa-miR-429 COL6A6 1.58250682050303 4.75828087352234e-05 1.04670724495871 0.00315333354883248 miRanda -0.152370219950005 0.00651679031582135 NA NA NA hsa-miR-532-3p COL6A6 1.35968112631236 2.41509711096659e-06 1.04670724495871 0.00315333354883248 MirTarget -0.175192700996974 0.0184275864754668 NA NA NA hsa-miR-577 COL6A6 0.615893340074725 0.210494450869356 1.04670724495871 0.00315333354883248 MirTarget;mirMAP -0.104918828857824 0.0302374757147205 NA NA NA hsa-miR-146b-5p COL9A1 2.23105707690238 3.83997814011313e-23 0.937485380504135 0.0332153040304691 miRanda;miRNATAP -0.224991059147086 0.0415876040960345 NA NA NA hsa-miR-27a-5p COL9A3 0.59763448976729 0.00736257811879899 -0.0232605680850297 0.953912641075929 MirTarget -0.254973139723212 0.0206711387602988 NA NA NA hsa-let-7b-3p CREB1 0.377956364821509 0.0061730103051373 0.202904073954936 0.00536716751940416 MirTarget -0.156386138336101 9.94206336724814e-07 NA NA NA hsa-let-7f-1-3p CREB1 1.09636075438131 3.42037366931931e-10 0.202904073954936 0.00536716751940416 MirTarget -0.102186074686636 2.89576412473195e-05 NA NA NA hsa-miR-126-5p CREB1 0.450893496822779 0.0112966412858755 0.202904073954936 0.00536716751940416 mirMAP -0.157612546283334 6.71149841171744e-11 NA NA NA hsa-miR-140-5p CREB1 0.132398579631585 0.457960134430787 0.202904073954936 0.00536716751940416 miRanda -0.150354238009237 6.37988121619696e-10 NA NA NA hsa-miR-186-5p CREB1 0.35512789129261 0.0196931838168008 0.202904073954936 0.00536716751940416 mirMAP -0.11888090808363 4.39953212013614e-05 NA NA NA hsa-miR-26a-5p CREB1 -0.507487084157331 3.23715933371269e-05 0.202904073954936 0.00536716751940416 MirTarget;mirMAP -0.227537185710506 1.38350647567537e-10 NA NA NA hsa-miR-26b-5p CREB1 -0.499493687076043 0.0118149973400486 0.202904073954936 0.00536716751940416 MirTarget;mirMAP -0.158380029327416 1.20985056350525e-13 NA NA NA hsa-miR-27a-3p CREB1 0.523219911315699 0.000116410279757859 0.202904073954936 0.00536716751940416 MirTarget -0.165645453518701 2.70933767675241e-07 NA NA NA hsa-miR-27b-3p CREB1 -0.439806942644624 0.000523870009254693 0.202904073954936 0.00536716751940416 MirTarget -0.117804776153589 0.000821250576171153 NA NA NA hsa-miR-28-5p CREB1 -0.22318016376076 0.0194144033008573 0.202904073954936 0.00536716751940416 PITA;miRNATAP -0.146967997516296 0.00232191782910429 NA NA NA hsa-miR-30b-5p CREB1 -0.0106833209203501 0.954966272944722 0.202904073954936 0.00536716751940416 MirTarget;mirMAP -0.12813122687947 2.79294580625651e-08 NA NA NA hsa-miR-30e-3p CREB1 -0.444998679251398 0.000501880465265124 0.202904073954936 0.00536716751940416 MirTarget -0.182795681640367 1.0193660459882e-07 NA NA NA hsa-miR-30e-5p CREB1 -0.284839730810255 0.0405852891523165 0.202904073954936 0.00536716751940416 MirTarget;mirMAP -0.134844586508406 2.49431457993712e-05 NA NA NA hsa-miR-33a-3p CREB1 0.21453033253985 0.371591474252951 0.202904073954936 0.00536716751940416 MirTarget -0.114579375572934 1.08177151713888e-09 NA NA NA hsa-miR-374a-3p CREB1 0.0703956336838676 0.602396227448772 0.202904073954936 0.00536716751940416 mirMAP -0.113924922097434 0.000622115611882151 NA NA NA hsa-miR-374b-5p CREB1 0.00249900187478502 0.985380083859555 0.202904073954936 0.00536716751940416 mirMAP -0.166596294178539 3.04651327975647e-07 NA NA NA hsa-miR-378a-5p CREB1 -0.684033095877066 0.000471076679969606 0.202904073954936 0.00536716751940416 MirTarget -0.105955503312604 1.82078576681385e-06 NA NA NA hsa-miR-107 CREB3 0.85152957824299 1.22369651446858e-11 -0.480292523081474 9.68258037064228e-06 miRanda -0.182055115050947 0.000484646852339431 NA NA NA hsa-let-7a-5p CREB3L2 0.298659498236324 0.00963231738125113 -0.525060002905056 1.65437910930531e-05 mirMAP -0.141231991610828 0.035481118569235 NA NA NA hsa-let-7d-5p CREB3L2 0.686819803681087 1.08347860862215e-06 -0.525060002905056 1.65437910930531e-05 mirMAP -0.308248095665787 2.96955169534544e-09 NA NA NA hsa-let-7f-5p CREB3L2 0.300925310468863 0.0221019558342241 -0.525060002905056 1.65437910930531e-05 mirMAP -0.17880874866083 0.00214406114563624 NA NA NA hsa-let-7g-5p CREB3L2 0.296128761926282 0.0296823495976068 -0.525060002905056 1.65437910930531e-05 mirMAP -0.257192588363217 3.62846524443742e-06 NA NA NA hsa-let-7i-5p CREB3L2 0.90895826823783 5.79676789748755e-17 -0.525060002905056 1.65437910930531e-05 mirMAP -0.161789797806775 0.0161895418751383 NA NA NA hsa-miR-106b-5p CREB3L2 1.08518388423396 4.82746923373852e-09 -0.525060002905056 1.65437910930531e-05 mirMAP -0.283698229933595 8.07165105725383e-14 NA NA NA hsa-miR-126-5p CREB3L2 0.450893496822779 0.0112966412858755 -0.525060002905056 1.65437910930531e-05 mirMAP -0.105919320835948 0.0128923018493436 NA NA NA hsa-miR-128-3p CREB3L2 0.835320684237761 1.85756253116961e-09 -0.525060002905056 1.65437910930531e-05 MirTarget -0.289792933380835 2.97896526153494e-08 NA NA NA hsa-miR-141-3p CREB3L2 1.76274853293464 9.99331900755725e-07 -0.525060002905056 1.65437910930531e-05 MirTarget -0.135905294060724 5.18930262625968e-12 NA NA NA hsa-miR-146a-5p CREB3L2 0.801543189433048 0.00411744525146003 -0.525060002905056 1.65437910930531e-05 mirMAP -0.104401654306089 8.81212517388855e-05 NA NA NA hsa-miR-146b-5p CREB3L2 2.23105707690238 3.83997814011313e-23 -0.525060002905056 1.65437910930531e-05 miRanda;mirMAP -0.119648083155724 8.85039729293425e-05 NA NA NA hsa-miR-16-2-3p CREB3L2 0.869267463341732 0.000785361809327569 -0.525060002905056 1.65437910930531e-05 mirMAP -0.150231048323876 1.1501436269272e-07 NA NA NA hsa-miR-16-5p CREB3L2 0.468459442059375 0.02635007201346 -0.525060002905056 1.65437910930531e-05 miRNAWalker2_validate -0.183482969404046 1.770961248215e-07 NA NA NA hsa-miR-17-5p CREB3L2 1.57209612312313 5.10453838016207e-11 -0.525060002905056 1.65437910930531e-05 mirMAP -0.204538623219874 2.54221649639436e-12 NA NA NA hsa-miR-181a-5p CREB3L2 1.39352013383959 4.74824377258519e-17 -0.525060002905056 1.65437910930531e-05 mirMAP -0.212466011510695 5.17729037600308e-07 NA NA NA hsa-miR-181b-5p CREB3L2 1.44365471425231 6.03807007335243e-15 -0.525060002905056 1.65437910930531e-05 mirMAP -0.211982376283628 2.42225980272326e-08 NA NA NA hsa-miR-182-5p CREB3L2 1.73826081735237 5.69817940588551e-09 -0.525060002905056 1.65437910930531e-05 mirMAP -0.161318127589747 8.58188697487495e-12 NA NA NA hsa-miR-185-5p CREB3L2 1.20157041272762 3.03584066444936e-15 -0.525060002905056 1.65437910930531e-05 MirTarget -0.275941986642213 2.2783697956477e-09 NA NA NA hsa-miR-186-5p CREB3L2 0.35512789129261 0.0196931838168008 -0.525060002905056 1.65437910930531e-05 MirTarget -0.16790139267481 0.00075754939450389 NA NA NA hsa-miR-18a-3p CREB3L2 1.42489363201958 4.87914808744785e-05 -0.525060002905056 1.65437910930531e-05 MirTarget -0.140325118647942 1.2289928660258e-09 NA NA NA hsa-miR-197-3p CREB3L2 0.540951726189935 0.00440139185360704 -0.525060002905056 1.65437910930531e-05 mirMAP -0.195781092437316 5.41933240133578e-07 NA NA NA hsa-miR-1976 CREB3L2 0.888680419203938 2.16642020734521e-05 -0.525060002905056 1.65437910930531e-05 MirTarget -0.158296951752309 1.9186766046276e-05 NA NA NA hsa-miR-19b-3p CREB3L2 0.936987029203338 9.28141970787798e-06 -0.525060002905056 1.65437910930531e-05 miRNAWalker2_validate -0.222710026463175 6.43028011606172e-11 NA NA NA hsa-miR-200a-3p CREB3L2 2.02394729844446 2.21240501925011e-08 -0.525060002905056 1.65437910930531e-05 MirTarget -0.134954094240171 4.25089203067284e-12 NA NA NA hsa-miR-20a-5p CREB3L2 1.57190995476158 8.72275528729458e-12 -0.525060002905056 1.65437910930531e-05 mirMAP -0.203829334395921 2.02807512050424e-11 NA NA NA hsa-miR-24-3p CREB3L2 0.425646348491286 0.00136678638934554 -0.525060002905056 1.65437910930531e-05 miRNATAP -0.275985747557996 1.04699056047665e-06 NA NA NA hsa-miR-25-3p CREB3L2 0.948739680210032 3.62304579611938e-09 -0.525060002905056 1.65437910930531e-05 MirTarget;miRNATAP -0.275238478131151 7.33313539875435e-10 NA NA NA hsa-miR-29b-1-5p CREB3L2 1.27585983480192 1.70509960024426e-05 -0.525060002905056 1.65437910930531e-05 mirMAP -0.111092007155521 7.91107598625383e-06 NA NA NA hsa-miR-32-5p CREB3L2 0.425717775201634 0.0402079308210921 -0.525060002905056 1.65437910930531e-05 MirTarget;miRNATAP -0.198479303316131 2.53173113917656e-08 NA NA NA hsa-miR-330-3p CREB3L2 0.391166748754241 0.0581284813543685 -0.525060002905056 1.65437910930531e-05 mirMAP -0.124971429874243 0.000940537198860457 NA NA NA hsa-miR-33a-3p CREB3L2 0.21453033253985 0.371591474252951 -0.525060002905056 1.65437910930531e-05 mirMAP -0.142675683182527 1.19061108297282e-05 NA NA NA hsa-miR-361-5p CREB3L2 0.538048008019709 1.61165802415302e-07 -0.525060002905056 1.65437910930531e-05 miRanda -0.295035772210729 6.38203121821665e-05 NA NA NA hsa-miR-362-5p CREB3L2 1.45312548529729 9.37098891085093e-09 -0.525060002905056 1.65437910930531e-05 mirMAP -0.148206544693762 1.8806272371935e-07 NA NA NA hsa-miR-429 CREB3L2 1.58250682050303 4.75828087352234e-05 -0.525060002905056 1.65437910930531e-05 miRNATAP -0.123449200306117 4.1894022922312e-11 NA NA NA hsa-miR-501-5p CREB3L2 1.59306197632625 2.04856600619363e-09 -0.525060002905056 1.65437910930531e-05 mirMAP -0.159365019056274 1.56954575604244e-08 NA NA NA hsa-miR-590-3p CREB3L2 0.858742926831233 0.000127281269371976 -0.525060002905056 1.65437910930531e-05 miRanda;miRNATAP -0.175675155049254 8.14218035714507e-08 NA NA NA hsa-miR-671-5p CREB3L2 1.6497630797889 2.89172004241043e-12 -0.525060002905056 1.65437910930531e-05 MirTarget -0.142734722497931 2.27493580252592e-06 NA NA NA hsa-miR-7-1-3p CREB3L2 0.94398354303717 7.5771319809992e-05 -0.525060002905056 1.65437910930531e-05 mirMAP -0.151171976942982 9.04260782091874e-07 NA NA NA hsa-miR-92a-1-5p CREB3L2 2.04820501765632 9.32117486799495e-13 -0.525060002905056 1.65437910930531e-05 MirTarget -0.134770980650094 7.77822784541326e-08 NA NA NA hsa-miR-92a-3p CREB3L2 1.06124545165614 6.51550014372282e-08 -0.525060002905056 1.65437910930531e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.244502494411652 1.6959913355578e-11 NA NA NA hsa-miR-92b-3p CREB3L2 1.10163066523605 4.43024463410466e-10 -0.525060002905056 1.65437910930531e-05 MirTarget;miRNATAP -0.168631527478275 4.30837448489784e-05 NA NA NA hsa-miR-96-5p CREB3L2 1.44821155854693 6.56312590328933e-06 -0.525060002905056 1.65437910930531e-05 MirTarget;TargetScan;miRNATAP -0.163213501117118 5.3624582387597e-12 NA NA NA hsa-miR-98-5p CREB3L2 0.72508924193932 6.07191196761022e-10 -0.525060002905056 1.65437910930531e-05 mirMAP -0.380607026756566 8.74405011054284e-10 NA NA NA hsa-miR-106b-5p CREB5 1.08518388423396 4.82746923373852e-09 0.0144734137836222 0.953004773309416 MirTarget;miRNATAP -0.473891034446076 6.46136356607143e-10 NA NA NA hsa-miR-107 CREB5 0.85152957824299 1.22369651446858e-11 0.0144734137836222 0.953004773309416 miRNATAP -0.461366471142928 7.00476765618112e-05 NA NA NA hsa-miR-10a-3p CREB5 0.673742947104233 0.000577781470262632 0.0144734137836222 0.953004773309416 mirMAP -0.203293246827393 0.00901416073432855 NA NA NA hsa-miR-126-5p CREB5 0.450893496822779 0.0112966412858755 0.0144734137836222 0.953004773309416 mirMAP -0.387100602903258 3.45994860758352e-06 NA NA NA hsa-miR-130b-3p CREB5 1.29757792612022 1.70655148591568e-06 0.0144734137836222 0.953004773309416 miRNATAP -0.387782603582986 6.92156657607979e-14 NA NA NA hsa-miR-135b-5p CREB5 2.80066701698235 2.12546333413447e-11 0.0144734137836222 0.953004773309416 MirTarget -0.105553587842045 0.00331362488173172 NA NA NA hsa-miR-141-3p CREB5 1.76274853293464 9.99331900755725e-07 0.0144734137836222 0.953004773309416 mirMAP -0.281966571553799 4.55374204405293e-13 NA NA NA hsa-miR-142-3p CREB5 1.80134804047727 3.87649742898476e-07 0.0144734137836222 0.953004773309416 miRNATAP -0.176509252427952 1.47530267007203e-05 NA NA NA hsa-miR-142-5p CREB5 1.08445947321046 0.000126372881543671 0.0144734137836222 0.953004773309416 mirMAP -0.269911005495726 1.44528035227614e-07 NA NA NA hsa-miR-15a-5p CREB5 1.07800995489566 4.32072598796529e-10 0.0144734137836222 0.953004773309416 miRNATAP -0.313185325438616 0.00019357896928698 NA NA NA hsa-miR-15b-5p CREB5 0.637819606405168 0.000580041575431604 0.0144734137836222 0.953004773309416 miRNATAP -0.442006475974844 2.06697934872227e-08 NA NA NA hsa-miR-16-2-3p CREB5 0.869267463341732 0.000785361809327569 0.0144734137836222 0.953004773309416 mirMAP -0.307417859480641 4.50895940817632e-08 NA NA NA hsa-miR-16-5p CREB5 0.468459442059375 0.02635007201346 0.0144734137836222 0.953004773309416 miRNATAP -0.43058273916855 4.50409890129185e-10 NA NA NA hsa-miR-17-5p CREB5 1.57209612312313 5.10453838016207e-11 0.0144734137836222 0.953004773309416 MirTarget;TargetScan;miRNATAP -0.211581872299335 0.000427012116350822 NA NA NA hsa-miR-182-5p CREB5 1.73826081735237 5.69817940588551e-09 0.0144734137836222 0.953004773309416 mirMAP -0.289811872192973 9.19187956564002e-10 NA NA NA hsa-miR-186-5p CREB5 0.35512789129261 0.0196931838168008 0.0144734137836222 0.953004773309416 mirMAP -0.417506538406726 2.21587956057118e-05 NA NA NA hsa-miR-19a-3p CREB5 1.71062381299889 1.72281025366819e-11 0.0144734137836222 0.953004773309416 mirMAP -0.224930099335547 6.25611812837908e-05 NA NA NA hsa-miR-19b-3p CREB5 0.936987029203338 9.28141970787798e-06 0.0144734137836222 0.953004773309416 mirMAP -0.306855472317567 9.21600364537882e-06 NA NA NA hsa-miR-200a-3p CREB5 2.02394729844446 2.21240501925011e-08 0.0144734137836222 0.953004773309416 mirMAP -0.263639813763713 1.03038591089295e-11 NA NA NA hsa-miR-200b-3p CREB5 2.06025765178663 3.07718049337497e-10 0.0144734137836222 0.953004773309416 TargetScan -0.277717096886131 7.85164672894072e-11 NA NA NA hsa-miR-200c-3p CREB5 1.74925752003763 3.42000026705311e-08 0.0144734137836222 0.953004773309416 miRNATAP -0.300348264455469 1.23895257070211e-11 NA NA NA hsa-miR-21-3p CREB5 1.87780012411493 8.38052480155167e-17 0.0144734137836222 0.953004773309416 mirMAP -0.23899279317426 0.000120500261368418 NA NA NA hsa-miR-212-3p CREB5 0.810640598956005 2.08058512206955e-06 0.0144734137836222 0.953004773309416 miRNATAP -0.331689377080444 0.000119719853786465 NA NA NA hsa-miR-26a-5p CREB5 -0.507487084157331 3.23715933371269e-05 0.0144734137836222 0.953004773309416 mirMAP -0.427167423293971 0.00053677295882367 NA NA NA hsa-miR-26b-3p CREB5 0.312629571566403 0.245454206213408 0.0144734137836222 0.953004773309416 MirTarget -0.219086758266074 7.36002960240808e-05 NA NA NA hsa-miR-26b-5p CREB5 -0.499493687076043 0.0118149973400486 0.0144734137836222 0.953004773309416 mirMAP -0.334527765857209 7.56054423889461e-06 NA NA NA hsa-miR-29a-3p CREB5 -0.235052170104117 0.138527567930958 0.0144734137836222 0.953004773309416 MirTarget;miRNATAP -0.518218059864062 2.95464418500236e-08 NA NA NA hsa-miR-29b-1-5p CREB5 1.27585983480192 1.70509960024426e-05 0.0144734137836222 0.953004773309416 mirMAP -0.208385405331697 2.56085559649486e-05 NA NA NA hsa-miR-29b-3p CREB5 0.0225365195743876 0.914313337784307 0.0144734137836222 0.953004773309416 MirTarget;miRNATAP -0.389209771992528 3.25735160481194e-08 NA NA NA hsa-miR-29c-3p CREB5 -1.34143813218298 2.77493790306384e-12 0.0144734137836222 0.953004773309416 MirTarget;miRNATAP -0.223407363879216 0.00291828339394581 NA NA NA hsa-miR-301a-3p CREB5 1.22580753116505 5.84016077664577e-09 0.0144734137836222 0.953004773309416 miRNATAP -0.236865589220632 0.000602848938310864 NA NA NA hsa-miR-3065-3p CREB5 -0.00685158653722073 0.979081293235379 0.0144734137836222 0.953004773309416 miRNATAP -0.138331136397142 0.0162518787705305 NA NA NA hsa-miR-30b-3p CREB5 0.252088263642787 0.216818735503048 0.0144734137836222 0.953004773309416 MirTarget -0.265438065447227 0.00031740345758963 NA NA NA hsa-miR-30d-3p CREB5 0.0608340295673737 0.708110230223927 0.0144734137836222 0.953004773309416 mirMAP -0.387507335044494 2.81129578074828e-05 NA NA NA hsa-miR-30e-3p CREB5 -0.444998679251398 0.000501880465265124 0.0144734137836222 0.953004773309416 mirMAP -0.267147486831332 0.0246173015422521 NA NA NA hsa-miR-32-5p CREB5 0.425717775201634 0.0402079308210921 0.0144734137836222 0.953004773309416 miRNAWalker2_validate -0.495765334337936 9.69174509799137e-13 NA NA NA hsa-miR-320b CREB5 1.21733873788625 7.99882585998487e-07 0.0144734137836222 0.953004773309416 MirTarget;PITA;miRanda;miRNATAP -0.279259785800467 1.97009307617798e-06 NA NA NA hsa-miR-330-3p CREB5 0.391166748754241 0.0581284813543685 0.0144734137836222 0.953004773309416 MirTarget;mirMAP -0.425834882588057 6.82107272210928e-09 NA NA NA hsa-miR-33a-3p CREB5 0.21453033253985 0.371591474252951 0.0144734137836222 0.953004773309416 miRNATAP -0.347232054732278 6.0907018374552e-08 NA NA NA hsa-miR-34a-5p CREB5 0.691825068787607 0.00069818668499891 0.0144734137836222 0.953004773309416 miRNATAP -0.29706629199733 4.14194481549316e-05 NA NA NA hsa-miR-3607-3p CREB5 0.479939234340415 0.251616873367277 0.0144734137836222 0.953004773309416 mirMAP -0.111261595197154 0.00247123324168607 NA NA NA hsa-miR-362-3p CREB5 0.994614346444282 4.39793878186399e-05 0.0144734137836222 0.953004773309416 PITA -0.333111539987774 6.36008064230571e-08 NA NA NA hsa-miR-429 CREB5 1.58250682050303 4.75828087352234e-05 0.0144734137836222 0.953004773309416 PITA;miRanda;miRNATAP -0.265761194355134 5.82622630244725e-13 NA NA NA hsa-miR-454-3p CREB5 0.823770738595667 1.30339728183332e-05 0.0144734137836222 0.953004773309416 miRNATAP -0.297843868995695 0.00013448395525899 NA NA NA hsa-miR-500a-5p CREB5 1.33126717816499 3.1497328652235e-07 0.0144734137836222 0.953004773309416 mirMAP -0.188212695129759 0.000793268286612946 NA NA NA hsa-miR-532-3p CREB5 1.35968112631236 2.41509711096659e-06 0.0144734137836222 0.953004773309416 miRNATAP -0.276145002074486 3.02009017838889e-08 NA NA NA hsa-miR-576-5p CREB5 0.872721964495849 5.20470410008775e-05 0.0144734137836222 0.953004773309416 PITA;mirMAP -0.33057935914791 1.05212429990799e-06 NA NA NA hsa-miR-577 CREB5 0.615893340074725 0.210494450869356 0.0144734137836222 0.953004773309416 PITA;mirMAP;miRNATAP -0.179297381215031 3.27158644395825e-08 NA NA NA hsa-miR-590-3p CREB5 0.858742926831233 0.000127281269371976 0.0144734137836222 0.953004773309416 PITA;mirMAP -0.441444969098438 5.02271514147574e-12 NA NA NA hsa-miR-590-5p CREB5 0.932604531809045 8.39043954167884e-05 0.0144734137836222 0.953004773309416 miRNATAP -0.307446238686893 6.04464770762056e-07 NA NA NA hsa-miR-671-5p CREB5 1.6497630797889 2.89172004241043e-12 0.0144734137836222 0.953004773309416 PITA -0.28662376160946 1.74785047179267e-06 NA NA NA hsa-miR-7-1-3p CREB5 0.94398354303717 7.5771319809992e-05 0.0144734137836222 0.953004773309416 mirMAP -0.373130605304195 6.29334044549502e-10 NA NA NA hsa-miR-769-5p CREB5 0.933922223076232 1.9485893796755e-09 0.0144734137836222 0.953004773309416 miRNATAP -0.235582352985715 0.0126892518481937 NA NA NA hsa-miR-93-5p CREB5 1.68243825551104 4.62947431501061e-15 0.0144734137836222 0.953004773309416 MirTarget;miRNATAP -0.14710310406045 0.0268247145905799 NA NA NA hsa-miR-940 CREB5 1.3080677738253 2.0056085433599e-05 0.0144734137836222 0.953004773309416 MirTarget -0.229221425012521 2.55565780591271e-06 NA NA NA hsa-miR-106a-5p CSF1 0.587427028487119 0.00838999163993323 0.0517214057689195 0.720203308078461 miRNATAP -0.147486676397501 0.000163544784383397 NA NA NA hsa-miR-106b-5p CSF1 1.08518388423396 4.82746923373852e-09 0.0517214057689195 0.720203308078461 miRNATAP -0.188148979666736 4.16176202570519e-05 NA NA NA hsa-miR-107 CSF1 0.85152957824299 1.22369651446858e-11 0.0517214057689195 0.720203308078461 miRanda -0.243842165476839 0.000355024418270374 NA NA NA hsa-miR-128-3p CSF1 0.835320684237761 1.85756253116961e-09 0.0517214057689195 0.720203308078461 MirTarget -0.21151184508333 0.000652169500374594 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130b-3p CSF1 1.29757792612022 1.70655148591568e-06 0.0517214057689195 0.720203308078461 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.116852636799595 0.00021775136689091 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-148b-3p CSF1 0.719517328390822 3.51245964668412e-05 0.0517214057689195 0.720203308078461 miRNAWalker2_validate -0.119317658663695 0.0178180950062033 NA NA NA hsa-miR-15a-5p CSF1 1.07800995489566 4.32072598796529e-10 0.0517214057689195 0.720203308078461 miRNATAP -0.179256067284789 0.000279361846039912 NA NA NA hsa-miR-15b-5p CSF1 0.637819606405168 0.000580041575431604 0.0517214057689195 0.720203308078461 miRNATAP -0.134508876856067 0.00444529985877819 NA NA NA hsa-miR-17-5p CSF1 1.57209612312313 5.10453838016207e-11 0.0517214057689195 0.720203308078461 TargetScan;miRNATAP -0.212692216127748 6.26171790989333e-10 NA NA NA hsa-miR-20a-5p CSF1 1.57190995476158 8.72275528729458e-12 0.0517214057689195 0.720203308078461 miRNATAP -0.234881566184629 3.56918214241675e-11 NA NA NA hsa-miR-27a-3p CSF1 0.523219911315699 0.000116410279757859 0.0517214057689195 0.720203308078461 MirTarget;miRNATAP -0.12875790208044 0.0489001014959164 NA NA NA hsa-miR-27b-3p CSF1 -0.439806942644624 0.000523870009254693 0.0517214057689195 0.720203308078461 MirTarget;miRNATAP -0.182726570304273 0.0093021134624157 NA NA NA hsa-miR-301a-3p CSF1 1.22580753116505 5.84016077664577e-09 0.0517214057689195 0.720203308078461 MirTarget;miRNATAP -0.133246832242362 0.00101626894561661 NA NA NA hsa-miR-30b-5p CSF1 -0.0106833209203501 0.954966272944722 0.0517214057689195 0.720203308078461 miRNAWalker2_validate -0.123549064272021 0.00840604413393966 NA NA NA hsa-miR-429 CSF1 1.58250682050303 4.75828087352234e-05 0.0517214057689195 0.720203308078461 PITA;miRanda;miRNATAP -0.129610624427917 3.76679247842576e-09 NA NA NA hsa-miR-532-5p CSF1 1.45407925817457 1.88450871132345e-14 0.0517214057689195 0.720203308078461 miRNATAP -0.10568935656252 0.016958569671843 NA NA NA hsa-miR-93-5p CSF1 1.68243825551104 4.62947431501061e-15 0.0517214057689195 0.720203308078461 miRNATAP -0.217730380911363 9.77822942832857e-09 NA NA NA hsa-miR-96-5p CSF1 1.44821155854693 6.56312590328933e-06 0.0517214057689195 0.720203308078461 miRNATAP -0.151352335923858 6.94314500003624e-08 NA NA NA hsa-miR-107 CSF1R 0.85152957824299 1.22369651446858e-11 -0.360721416288547 0.0865671900228986 miRanda -0.369230189490014 0.000218495903733861 NA NA NA hsa-miR-141-3p CSF3 1.76274853293464 9.99331900755725e-07 -0.848073603748178 0.13913951364429 TargetScan;miRNATAP -0.191444697732602 0.0449030935307389 NA NA NA hsa-miR-200a-3p CSF3 2.02394729844446 2.21240501925011e-08 -0.848073603748178 0.13913951364429 miRNATAP -0.225629585526738 0.0167065578346016 NA NA NA hsa-miR-181c-5p DDIT4 0.455531227606462 0.00194067309813448 -0.179787672926188 0.345373522733496 MirTarget -0.284578994000361 0.000331971274655076 NA NA NA hsa-miR-181d-5p DDIT4 0.731427823879034 2.03301498870394e-05 -0.179787672926188 0.345373522733496 MirTarget -0.30308662992731 5.12149873952735e-06 NA NA NA hsa-miR-217 DDIT4 1.80436036080313 4.35626260547444e-10 -0.179787672926188 0.345373522733496 miRanda -0.176816582195887 4.12150351471951e-06 NA NA NA hsa-miR-218-5p EFNA1 -0.615157868107884 0.00447149109697709 0.639258689836646 9.47542552405357e-05 miRNAWalker2_validate -0.175157203339035 0.000158149314435835 NA NA NA hsa-miR-30c-2-3p EFNA1 -0.850499600024184 1.80492410494116e-05 0.639258689836646 9.47542552405357e-05 MirTarget -0.151787542902098 0.00261357794603254 NA NA NA hsa-miR-145-5p EFNA3 -1.54503595327403 2.65080161523141e-09 1.15814860172927 4.09618172506155e-07 miRNATAP -0.282403029552 6.69283055843184e-08 NA NA NA hsa-miR-30a-5p EFNA3 -0.742755040631906 3.79943871404435e-05 1.15814860172927 4.09618172506155e-07 MirTarget;mirMAP;miRNATAP -0.505419582863486 3.07055832110817e-11 NA NA NA hsa-miR-103a-2-5p EFNA5 0.668868218338912 0.0220512854713701 -0.421335116813535 0.178679228276983 MirTarget -0.247754165476514 0.000960644759118942 NA NA NA hsa-miR-140-5p EFNA5 0.132398579631585 0.457960134430787 -0.421335116813535 0.178679228276983 miRanda -0.227886343407627 0.0360808173184196 NA NA NA hsa-miR-142-5p EFNA5 1.08445947321046 0.000126372881543671 -0.421335116813535 0.178679228276983 mirMAP;miRNATAP -0.149004389862529 0.0262232126862202 NA NA NA hsa-miR-144-3p EFNA5 -1.37061426401952 5.85913017989725e-05 -0.421335116813535 0.178679228276983 miRNATAP -0.175427771484246 0.00177167229875009 NA NA NA hsa-miR-15b-3p EFNA5 0.811179945491507 0.000927520880593552 -0.421335116813535 0.178679228276983 mirMAP -0.354214111170684 3.79756151131759e-06 NA NA NA hsa-miR-182-5p EFNA5 1.73826081735237 5.69817940588551e-09 -0.421335116813535 0.178679228276983 mirMAP;miRNATAP -0.306015267442825 5.78646437701797e-07 NA NA NA hsa-miR-185-3p EFNA5 1.38509197368746 3.93425296894499e-10 -0.421335116813535 0.178679228276983 miRNATAP -0.383673241999637 7.49712703640845e-06 NA NA NA hsa-miR-186-5p EFNA5 0.35512789129261 0.0196931838168008 -0.421335116813535 0.178679228276983 mirMAP -0.503949273414763 6.40600462144707e-05 NA NA NA hsa-miR-19a-3p EFNA5 1.71062381299889 1.72281025366819e-11 -0.421335116813535 0.178679228276983 miRNATAP -0.392325321038496 3.08302812920455e-08 NA NA NA hsa-miR-19b-3p EFNA5 0.936987029203338 9.28141970787798e-06 -0.421335116813535 0.178679228276983 miRNATAP -0.469482324704771 8.69492964690867e-08 NA NA NA hsa-miR-200b-3p EFNA5 2.06025765178663 3.07718049337497e-10 -0.421335116813535 0.178679228276983 TargetScan -0.206540537480006 0.000230717411847866 NA NA NA hsa-miR-200c-3p EFNA5 1.74925752003763 3.42000026705311e-08 -0.421335116813535 0.178679228276983 miRNATAP -0.251614462188857 1.50020840299045e-05 NA NA NA hsa-miR-20a-3p EFNA5 0.703027135708586 0.022464856696655 -0.421335116813535 0.178679228276983 mirMAP -0.281461508663276 8.68782186486521e-06 NA NA NA hsa-miR-2110 EFNA5 0.359318473683641 0.126104910543249 -0.421335116813535 0.178679228276983 mirMAP;miRNATAP -0.442505571260689 1.9283491277501e-07 NA NA NA hsa-miR-30b-3p EFNA5 0.252088263642787 0.216818735503048 -0.421335116813535 0.178679228276983 MirTarget -0.307513321637071 0.00113191698062348 NA NA NA hsa-miR-330-3p EFNA5 0.391166748754241 0.0581284813543685 -0.421335116813535 0.178679228276983 mirMAP;miRNATAP -0.257823310742373 0.0074251830291083 NA NA NA hsa-miR-335-3p EFNA5 2.29463721765513 4.1956113745077e-18 -0.421335116813535 0.178679228276983 mirMAP -0.268047361383274 6.5851124205589e-05 NA NA NA hsa-miR-335-5p EFNA5 0.576542642348884 0.01886326850059 -0.421335116813535 0.178679228276983 miRNAWalker2_validate -0.243929469030148 0.00176997208493986 NA NA NA hsa-miR-33a-3p EFNA5 0.21453033253985 0.371591474252951 -0.421335116813535 0.178679228276983 mirMAP -0.319995258407575 0.000117514209490648 NA NA NA hsa-miR-362-3p EFNA5 0.994614346444282 4.39793878186399e-05 -0.421335116813535 0.178679228276983 miRanda -0.331690469831818 3.10688286982414e-05 NA NA NA hsa-miR-378a-3p EFNA5 -0.640299638006855 0.000817347521910841 -0.421335116813535 0.178679228276983 miRNATAP -0.402239952804882 4.86324375223281e-05 NA NA NA hsa-miR-421 EFNA5 1.26653675546617 2.35180826009926e-08 -0.421335116813535 0.178679228276983 mirMAP -0.424917660342407 2.00087627654898e-07 NA NA NA hsa-miR-424-3p EFNA5 1.17280406786164 6.25288470591148e-06 -0.421335116813535 0.178679228276983 mirMAP -0.23055172396455 0.00257776240552768 NA NA NA hsa-miR-429 EFNA5 1.58250682050303 4.75828087352234e-05 -0.421335116813535 0.178679228276983 miRNATAP -0.175122921836083 0.000343172009573126 NA NA NA hsa-miR-450b-5p EFNA5 1.36137774989901 7.45499130609203e-11 -0.421335116813535 0.178679228276983 mirMAP -0.204269822227404 0.0213799149643686 NA NA NA hsa-miR-501-5p EFNA5 1.59306197632625 2.04856600619363e-09 -0.421335116813535 0.178679228276983 mirMAP -0.323534496774236 7.87480486170552e-06 NA NA NA hsa-miR-542-3p EFNA5 1.12416854979951 1.02649534578738e-12 -0.421335116813535 0.178679228276983 miRanda;mirMAP -0.29262103315111 0.0127709687821515 NA NA NA hsa-miR-577 EFNA5 0.615893340074725 0.210494450869356 -0.421335116813535 0.178679228276983 mirMAP -0.198136875379075 2.12925393897854e-06 NA NA NA hsa-miR-590-3p EFNA5 0.858742926831233 0.000127281269371976 -0.421335116813535 0.178679228276983 miRanda;mirMAP -0.306587397873452 0.000281185404312008 NA NA NA hsa-miR-7-1-3p EFNA5 0.94398354303717 7.5771319809992e-05 -0.421335116813535 0.178679228276983 mirMAP -0.394798287534353 4.2616393109062e-07 NA NA NA hsa-miR-92a-3p EFNA5 1.06124545165614 6.51550014372282e-08 -0.421335116813535 0.178679228276983 miRNAWalker2_validate -0.564028372215085 1.3245596252088e-09 NA NA NA hsa-miR-96-5p EFNA5 1.44821155854693 6.56312590328933e-06 -0.421335116813535 0.178679228276983 TargetScan -0.336453982240963 3.63275347005081e-08 NA NA NA hsa-miR-107 EGFR 0.85152957824299 1.22369651446858e-11 -0.174568357475892 0.484508576205495 miRanda -0.42688530955315 0.000310003899342301 NA NA NA hsa-miR-126-5p EGFR 0.450893496822779 0.0112966412858755 -0.174568357475892 0.484508576205495 mirMAP -0.227892196107298 0.00806342930108241 NA NA NA hsa-miR-128-3p EGFR 0.835320684237761 1.85756253116961e-09 -0.174568357475892 0.484508576205495 miRNAWalker2_validate;miRTarBase -0.518447696294981 1.09105759474168e-06 NA NA NA hsa-miR-140-5p EGFR 0.132398579631585 0.457960134430787 -0.174568357475892 0.484508576205495 miRanda -0.288791462585143 0.000779461842749479 NA NA NA hsa-miR-141-3p EGFR 1.76274853293464 9.99331900755725e-07 -0.174568357475892 0.484508576205495 MirTarget -0.142805261893094 0.000520017512800255 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-141-5p EGFR 2.13747696823946 1.73124674554872e-11 -0.174568357475892 0.484508576205495 MirTarget -0.142032616039967 0.00197947705336657 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-142-3p EGFR 1.80134804047727 3.87649742898476e-07 -0.174568357475892 0.484508576205495 miRanda -0.163798644838843 8.15271217437152e-05 NA NA NA hsa-miR-146a-5p EGFR 0.801543189433048 0.00411744525146003 -0.174568357475892 0.484508576205495 miRNAWalker2_validate -0.248423727667003 3.42448360502436e-06 21632853;25242818;22161865;25596948;24895573;25417703;23555954;24839931 The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases;Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC ;;progression;;;;; gastric cancer;pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer hsa-miR-146b-5p EGFR 2.23105707690238 3.83997814011313e-23 -0.174568357475892 0.484508576205495 miRNATAP -0.184260518729299 0.00299132496562976 NA NA NA hsa-miR-148b-5p EGFR 0.7888996589349 0.00420956802908159 -0.174568357475892 0.484508576205495 mirMAP -0.182002218445489 0.00205667223477432 NA NA NA hsa-miR-155-5p EGFR 0.708423342476697 0.00686702252429413 -0.174568357475892 0.484508576205495 miRNAWalker2_validate;MirTarget -0.141357856151302 0.014760146223104 NA NA NA hsa-miR-15b-3p EGFR 0.811179945491507 0.000927520880593552 -0.174568357475892 0.484508576205495 mirMAP -0.265037522175785 1.45177138337982e-05 NA NA NA hsa-miR-16-2-3p EGFR 0.869267463341732 0.000785361809327569 -0.174568357475892 0.484508576205495 mirMAP -0.239986436194011 3.36214332779806e-05 NA NA NA hsa-miR-16-5p EGFR 0.468459442059375 0.02635007201346 -0.174568357475892 0.484508576205495 miRNAWalker2_validate -0.348371726581681 1.00705856880478e-06 NA NA NA hsa-miR-17-5p EGFR 1.57209612312313 5.10453838016207e-11 -0.174568357475892 0.484508576205495 TargetScan -0.263902065129778 1.38902056427936e-05 NA NA NA hsa-miR-186-5p EGFR 0.35512789129261 0.0196931838168008 -0.174568357475892 0.484508576205495 mirMAP -0.395623883836065 8.07814052673303e-05 NA NA NA hsa-miR-188-5p EGFR 1.57437249320621 2.78824007819973e-08 -0.174568357475892 0.484508576205495 mirMAP -0.214917527478301 8.49910987712697e-05 NA NA NA hsa-miR-192-5p EGFR 2.0867723747501 3.57854249239079e-08 -0.174568357475892 0.484508576205495 mirMAP -0.101469705987116 0.00947566210441527 NA NA NA hsa-miR-19b-1-5p EGFR 1.78323584062047 7.55784857614623e-15 -0.174568357475892 0.484508576205495 MirTarget;mirMAP -0.241363022248661 0.000117204110239978 NA NA NA hsa-miR-200a-3p EGFR 2.02394729844446 2.21240501925011e-08 -0.174568357475892 0.484508576205495 MirTarget -0.149920239738882 0.000226081981008851 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-26b-3p EGFR 0.312629571566403 0.245454206213408 -0.174568357475892 0.484508576205495 mirMAP -0.14394918637469 0.0111476481987049 NA NA NA hsa-miR-29b-1-5p EGFR 1.27585983480192 1.70509960024426e-05 -0.174568357475892 0.484508576205495 mirMAP -0.103316392419325 0.0428466949321739 NA NA NA hsa-miR-30d-3p EGFR 0.0608340295673737 0.708110230223927 -0.174568357475892 0.484508576205495 mirMAP -0.204714713254414 0.0316743325287577 NA NA NA hsa-miR-320a EGFR 0.451741078692272 0.00893327237386749 -0.174568357475892 0.484508576205495 miRanda;mirMAP -0.206052380383041 0.0203021476034849 NA NA NA hsa-miR-320b EGFR 1.21733873788625 7.99882585998487e-07 -0.174568357475892 0.484508576205495 miRanda;mirMAP -0.179826229442846 0.00296028993966972 NA NA NA hsa-miR-335-5p EGFR 0.576542642348884 0.01886326850059 -0.174568357475892 0.484508576205495 miRNAWalker2_validate -0.175536043258831 0.00476522302560093 NA NA NA hsa-miR-339-5p EGFR 0.51232205151031 0.0560469213103598 -0.174568357475892 0.484508576205495 miRanda -0.125569719516898 0.027323090658512 NA NA NA hsa-miR-340-5p EGFR 0.344103676703511 0.0160638942614091 -0.174568357475892 0.484508576205495 mirMAP -0.286475161838845 0.00801202886206328 NA NA NA hsa-miR-342-3p EGFR 0.235422340773149 0.290471946350276 -0.174568357475892 0.484508576205495 miRanda -0.18268445936043 0.00785457171147864 NA NA NA hsa-miR-362-5p EGFR 1.45312548529729 9.37098891085093e-09 -0.174568357475892 0.484508576205495 mirMAP -0.244873226924951 2.41343293539301e-05 NA NA NA hsa-miR-374a-3p EGFR 0.0703956336838676 0.602396227448772 -0.174568357475892 0.484508576205495 mirMAP -0.298606055059341 0.00957009970720965 NA NA NA hsa-miR-3913-5p EGFR 1.03696691062365 1.67224447360466e-09 -0.174568357475892 0.484508576205495 mirMAP -0.253762301157837 0.00346760502837924 NA NA NA hsa-miR-455-5p EGFR 0.644390760445571 0.00262275997170695 -0.174568357475892 0.484508576205495 miRanda -0.380770805450414 4.21563229198112e-08 NA NA NA hsa-miR-501-5p EGFR 1.59306197632625 2.04856600619363e-09 -0.174568357475892 0.484508576205495 mirMAP -0.217709610795273 0.000171194948946475 NA NA NA hsa-miR-542-3p EGFR 1.12416854979951 1.02649534578738e-12 -0.174568357475892 0.484508576205495 miRanda -0.334901042410827 0.000312627168825039 NA NA NA hsa-miR-590-3p EGFR 0.858742926831233 0.000127281269371976 -0.174568357475892 0.484508576205495 mirMAP -0.290365929030522 1.38489653810831e-05 NA NA NA hsa-miR-590-5p EGFR 0.932604531809045 8.39043954167884e-05 -0.174568357475892 0.484508576205495 miRanda;mirMAP -0.25885001207262 4.16304716148923e-05 NA NA NA hsa-miR-7-1-3p EGFR 0.94398354303717 7.5771319809992e-05 -0.174568357475892 0.484508576205495 mirMAP -0.184791968739449 0.00341896373066296 NA NA NA hsa-miR-7-5p EGFR 1.20202447072014 0.000123775346787165 -0.174568357475892 0.484508576205495 miRNAWalker2_validate;miRTarBase;MirTarget -0.155396919985607 0.00243518199644184 24573489;26708917;23115635;25503932;21712475;25334070;25532106;27203220;25862909;24816687;20978205;24603851;25289099;23227519 Further study will investigate miR-7 in the regulation of EGFR expression in vitro and in vivo;In addition the experimental data also suggest that miR-7 can interfere with EGFR mRNA translation; In addition miR-7 may function by interfering with EGFR mRNA translation but not degradation;Several studies have demonstrated that microRNA-7 miR-7 regulates EGFR expression and Akt activity in a range of cancer cell types via its specific interaction with the EGFR mRNA 3'-untranslated region 3'-UTR; Together these data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease;The potential for miR-7 to act as a tumor suppressor by coordinately regulating the epidermal growth factor receptor EGFR signaling pathway at several levels was examined; We investigated the tumor inhibitory effect of miR-7 in CRC with particular focus on the relationship between miR-7 and the EGFR pathway; The regulation of EGFR by miR-7 was examined with miR-7 precursor-transfected cells; Furthermore we investigated whether miR-7 suppresses proliferation of CRC cells in combination with cetuximab a monoclonal antibody against EGFR; In vitro assays showed that EGFR and RAF-1 are direct targets of miR-7 which potently suppressed the proliferation of CRC cells and interestingly that the growth inhibitory effect of each of these was enhanced by cetuximab;To overcome the resistance we focused on EGFR suppression using microRNA-7 miR-7 targeting multiple sites in the 3'-untranslated region of EGFR mRNA;Furthermore inhibition of EGFR showed similar effects to miR-7 enforcement in 3LL cells; Taken together these findings revealed that miR-7 acts as an antitumor miRNA in 3LL by targeting and suppressing the expression of both EGFR and RAF-1 oncogenes;MiR-7 inhibited MCF-7/HER2Δ16 cell migration through a mechanism involving suppression of the miR-7 target gene EGFR; In contrast miR-7 inhibition of MCF-7/HER2Δ16 cell proliferation involved a pathway where miR-7 expression resulted in the inactivation of Src kinase independent of suppressed EGFR expression; Also independent of EGFR suppression reestablished miR-7 expression sensitized refractory MCF-7/HER2Δ16 cells to trastuzumab; We propose that miR-7 regulated pathways including EGFR and Src kinase represent targets for the therapeutic intervention of refractory and metastatic HER2Δ16 driven breast cancer;microRNA-7-5p miR-7-5p is a tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor EGFR signaling pathway;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;In recent years mounting evidence indicates that EGFR is a direct and functional target of miR-7; In this study we found that miR-7 expression was significantly downregulated in highly metastatic epithelial ovarian cancer EOC cell lines and metastatic tissues whereas the expression of EGFR correlated positively with metastasis in both EOC patients and cell lines; Finally the expression of miR-7 and EGFR in primary EOC with matched metastasis tissues was explored; It was showed that miR-7 is inversely correlated with EGFR; Taken together our results suggested that miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in EOC cell lines;In this study we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells;We show that microRNA-7 miR-7 is a common regulator of the phosphoinositide-3-kinase PI3K/ATK and Raf/mitogen-activated protein kinase kinase MEK/extracellular signal-regulated kinase ERK pathways both of which are launched by EGFR through its two direct targets the transcription factors PI3K and Raf-1 respectively; We conclude that miR-7 is a potential tumor suppressor in glioblastoma that acts by targeting multiple oncogenes related to the downstream pathway of EGFR and may serve as a novel therapeutic target for malignant gliomas;Pretreatment of miR-7 mimics enhanced the PTX-mediated downregulation of epidermal growth factor receptor EGFR in NSCLC cells;We identified miR-7 as the important miRNA associated with estrogen actions in these cells and further examined the changes of estrogen-dependent EGFR expression by miR-7 in ER-positive or -negative breast carcinoma cell lines including MCF-7; We also evaluated the correlation between miR-7 and EGFR expression in breast carcinoma cells derived from 21 patients using laser capture microdissection combined with quantitative reverse transcriptase-PCR; miR-7 was reported to suppress epidermal growth factor receptor EGFR expression in several human malignancies; Transfection of miR-7 significantly suppressed EGFR mRNA levels in MCF-7 cells; We also evaluated the status of miR-7 in breast carcinoma tissues but the correlation between the status of miR-7 and EGFR in carcinoma cells isolated by laser capture microscopy was not detected; These results suggest that miR-7 may play a role in the development of resistance to endocrine therapy in breast cancer patients through regulating EGFR expression of carcinoma cells ;;;;drug resistance;;cell migration;;;metastasis;;malignant trasformation;;drug resistance gastric cancer;esophageal cancer;head and neck cancer;colorectal cancer;lung cancer;lung cancer;breast cancer;melanoma;ovarian cancer;ovarian cancer;lung cancer;glioblastoma;lung squamous cell cancer;breast cancer hsa-miR-769-5p EGFR 0.933922223076232 1.9485893796755e-09 -0.174568357475892 0.484508576205495 mirMAP -0.454566649827298 1.56222730989939e-06 NA NA NA hsa-miR-877-5p EGFR 1.86786864338556 8.44059777969251e-10 -0.174568357475892 0.484508576205495 mirMAP -0.169038255754857 0.00126265430274932 NA NA NA hsa-miR-25-3p EIF4B 0.948739680210032 3.62304579611938e-09 -0.328508607700186 0.000244831291658155 miRNAWalker2_validate -0.121992008362539 0.000249152861133695 NA NA NA hsa-miR-195-3p EIF4E -0.694544351365025 0.000214711021317786 -0.212443161100762 0.0349398332982134 mirMAP -0.123519272032353 0.000137751277620406 NA NA NA hsa-miR-125b-5p EIF4EBP1 -0.176364454911029 0.43771853581292 0.327627886088012 0.0590121699387604 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.107258997506258 0.0223839505606174 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-30c-2-3p EPHA2 -0.850499600024184 1.80492410494116e-05 0.413968720468568 0.084270104278866 MirTarget -0.232557856451551 0.00144836889521581 NA NA NA hsa-miR-144-5p F2R -1.23013364182798 6.303428978396e-06 1.53799894933921 7.40461613234673e-18 MirTarget -0.163593122479307 8.96434907502444e-05 NA NA NA hsa-miR-190a-5p F2R 0.065401777822546 0.738987081265067 1.53799894933921 7.40461613234673e-18 MirTarget -0.118761626275974 0.0479854884616614 NA NA NA hsa-miR-486-5p F2R -1.52128065772506 4.50915908626354e-09 1.53799894933921 7.40461613234673e-18 miRanda -0.182539199796201 2.39999578564629e-05 NA NA NA hsa-miR-582-5p F2R 0.0720675907490005 0.728284850619144 1.53799894933921 7.40461613234673e-18 MirTarget -0.159626204746197 0.00475124618892172 NA NA NA hsa-miR-664a-3p F2R -0.0290482945770787 0.844010225386475 1.53799894933921 7.40461613234673e-18 mirMAP -0.195239476249049 0.0152357700617202 NA NA NA hsa-let-7e-5p FASLG 0.227253058773149 0.162290058199053 0.53750001836942 0.081348046612573 miRNATAP -0.406363832920736 0.000506478526276418 NA NA NA hsa-miR-126-5p FGF1 0.450893496822779 0.0112966412858755 -0.0632327842797822 0.782087145069923 mirMAP -0.360513375374941 3.41119114893062e-06 NA NA NA hsa-miR-136-5p FGF1 0.501768051727903 0.0272130411225693 -0.0632327842797822 0.782087145069923 mirMAP -0.129640771815751 0.0351639461145594 NA NA NA hsa-miR-146b-3p FGF1 2.08650140817622 5.3293570720033e-22 -0.0632327842797822 0.782087145069923 miRNATAP -0.207068746247816 0.000470150733718735 NA NA NA hsa-miR-16-1-3p FGF1 1.23864765632542 1.24544799589822e-08 -0.0632327842797822 0.782087145069923 mirMAP -0.482685840094424 3.49084453096863e-15 NA NA NA hsa-miR-186-5p FGF1 0.35512789129261 0.0196931838168008 -0.0632327842797822 0.782087145069923 mirMAP -0.60151209568838 1.62619284604818e-11 NA NA NA hsa-miR-18a-5p FGF1 2.04701000113742 1.30593450319289e-12 -0.0632327842797822 0.782087145069923 MirTarget -0.361482447479576 1.16450689829645e-16 NA NA NA hsa-miR-193a-3p FGF1 0.148284355948959 0.379093889907371 -0.0632327842797822 0.782087145069923 PITA -0.178474988412403 0.0333377905956191 NA NA NA hsa-miR-21-5p FGF1 2.21515015440792 6.0468197386674e-49 -0.0632327842797822 0.782087145069923 MirTarget -0.178478383763349 0.0214800108232768 NA NA NA hsa-miR-222-5p FGF1 1.40730191326147 1.77506391601374e-06 -0.0632327842797822 0.782087145069923 MirTarget -0.326563894495556 4.85663210725741e-13 NA NA NA hsa-miR-26b-3p FGF1 0.312629571566403 0.245454206213408 -0.0632327842797822 0.782087145069923 MirTarget -0.316693240024071 3.04866361166942e-10 NA NA NA hsa-miR-29a-5p FGF1 1.00715634051951 4.47499137997344e-07 -0.0632327842797822 0.782087145069923 mirMAP -0.409563882731917 8.71200443390904e-10 NA NA NA hsa-miR-320a FGF1 0.451741078692272 0.00893327237386749 -0.0632327842797822 0.782087145069923 miRanda -0.189214790047522 0.0198398034256704 NA NA NA hsa-miR-320b FGF1 1.21733873788625 7.99882585998487e-07 -0.0632327842797822 0.782087145069923 miRanda -0.292517525689569 7.24344109932426e-08 NA NA NA hsa-miR-326 FGF1 -0.552187708067123 0.039648668341622 -0.0632327842797822 0.782087145069923 miRanda;miRNATAP -0.202393746440028 8.69801811736883e-05 NA NA NA hsa-miR-330-5p FGF1 0.621676971901542 0.00233177378595631 -0.0632327842797822 0.782087145069923 miRanda;miRNATAP -0.511968623090898 2.59057185641691e-15 NA NA NA hsa-miR-374a-3p FGF1 0.0703956336838676 0.602396227448772 -0.0632327842797822 0.782087145069923 mirMAP -0.313187706133428 0.00291755726300571 NA NA NA hsa-miR-429 FGF1 1.58250682050303 4.75828087352234e-05 -0.0632327842797822 0.782087145069923 miRNATAP -0.329686838440385 1.04764315971249e-23 NA NA NA hsa-miR-484 FGF1 0.401753773460753 0.0490851523101605 -0.0632327842797822 0.782087145069923 MirTarget;PITA;miRNATAP -0.46203265966411 2.33296142686291e-12 NA NA NA hsa-miR-532-3p FGF1 1.35968112631236 2.41509711096659e-06 -0.0632327842797822 0.782087145069923 miRNATAP -0.361305257079927 9.30112395979199e-16 NA NA NA hsa-miR-550a-5p FGF1 1.55643544666056 8.53097422057455e-09 -0.0632327842797822 0.782087145069923 MirTarget -0.262927482070555 1.57412160910016e-07 NA NA NA hsa-miR-576-5p FGF1 0.872721964495849 5.20470410008775e-05 -0.0632327842797822 0.782087145069923 PITA;mirMAP -0.398330616381459 1.33324568686148e-10 NA NA NA hsa-miR-590-5p FGF1 0.932604531809045 8.39043954167884e-05 -0.0632327842797822 0.782087145069923 MirTarget;miRanda;miRNATAP -0.420694210261633 4.07885539406644e-14 NA NA NA hsa-miR-625-5p FGF1 0.748754910408313 0.00783938428700196 -0.0632327842797822 0.782087145069923 MirTarget -0.435563535889276 6.71578193009218e-21 NA NA NA hsa-miR-629-5p FGF1 0.812778109967063 7.88203035554668e-05 -0.0632327842797822 0.782087145069923 MirTarget -0.417118142882039 1.62024038214274e-10 NA NA NA hsa-miR-7-5p FGF1 1.20202447072014 0.000123775346787165 -0.0632327842797822 0.782087145069923 miRNAWalker2_validate -0.343918555127513 1.57740821455389e-14 NA NA NA hsa-miR-935 FGF1 2.321600496365 1.00042201726114e-07 -0.0632327842797822 0.782087145069923 MirTarget;miRNATAP -0.117848663753806 0.000315376035823438 NA NA NA hsa-miR-200b-3p FGF10 2.06025765178663 3.07718049337497e-10 -1.8542097387882 2.08993527096072e-05 TargetScan -0.712312310936586 3.76939499928314e-22 NA NA NA hsa-miR-335-5p FGF10 0.576542642348884 0.01886326850059 -1.8542097387882 2.08993527096072e-05 miRNAWalker2_validate -0.464582328240339 2.16219925125692e-05 NA NA NA hsa-miR-33a-3p FGF10 0.21453033253985 0.371591474252951 -1.8542097387882 2.08993527096072e-05 mirMAP -0.708746898324086 6.81548825041692e-10 NA NA NA hsa-miR-664a-3p FGF10 -0.0290482945770787 0.844010225386475 -1.8542097387882 2.08993527096072e-05 mirMAP -0.453120387785907 0.0152256355792097 NA NA NA hsa-miR-10a-5p FGF11 0.194246363236601 0.254210414179487 0.366898790518822 0.129200051862417 mirMAP -0.189280626982258 0.031300943739499 NA NA NA hsa-let-7a-3p FGF12 0.283468597868531 0.127007787220086 -0.170390023502168 0.492844460583921 MirTarget -0.469702097849656 4.58671788693495e-09 NA NA NA hsa-let-7b-3p FGF12 0.377956364821509 0.0061730103051373 -0.170390023502168 0.492844460583921 MirTarget -0.502957899746297 4.69667245832804e-06 NA NA NA hsa-let-7f-1-3p FGF12 1.09636075438131 3.42037366931931e-10 -0.170390023502168 0.492844460583921 MirTarget -0.445154457069955 7.81734608450878e-08 NA NA NA hsa-miR-107 FGF12 0.85152957824299 1.22369651446858e-11 -0.170390023502168 0.492844460583921 miRanda -0.263545591233634 0.0263506991849909 NA NA NA hsa-miR-142-5p FGF12 1.08445947321046 0.000126372881543671 -0.170390023502168 0.492844460583921 miRNATAP -0.343994993948348 1.67146704801946e-11 NA NA NA hsa-miR-17-5p FGF12 1.57209612312313 5.10453838016207e-11 -0.170390023502168 0.492844460583921 TargetScan -0.225104807313555 0.000209233113407568 NA NA NA hsa-miR-197-3p FGF12 0.540951726189935 0.00440139185360704 -0.170390023502168 0.492844460583921 MirTarget -0.307671914595636 0.000104790169095246 NA NA NA hsa-miR-200b-3p FGF12 2.06025765178663 3.07718049337497e-10 -0.170390023502168 0.492844460583921 TargetScan -0.206614309600595 2.72454763868074e-06 NA NA NA hsa-miR-2355-3p FGF12 0.101789577163865 0.693158423682028 -0.170390023502168 0.492844460583921 MirTarget;miRNATAP -0.19049443157843 0.001904324581397 NA NA NA hsa-miR-29a-5p FGF12 1.00715634051951 4.47499137997344e-07 -0.170390023502168 0.492844460583921 MirTarget -0.486928425028623 1.44552128126299e-11 NA NA NA hsa-miR-335-3p FGF12 2.29463721765513 4.1956113745077e-18 -0.170390023502168 0.492844460583921 MirTarget -0.185181547582455 0.000520980971873456 NA NA NA hsa-miR-33a-3p FGF12 0.21453033253985 0.371591474252951 -0.170390023502168 0.492844460583921 mirMAP -0.319755052371434 9.42679958676633e-07 NA NA NA hsa-miR-342-3p FGF12 0.235422340773149 0.290471946350276 -0.170390023502168 0.492844460583921 miRanda -0.261452038067563 0.000117156212512717 NA NA NA hsa-miR-362-3p FGF12 0.994614346444282 4.39793878186399e-05 -0.170390023502168 0.492844460583921 miRanda -0.247655882376786 8.81177048413029e-05 NA NA NA hsa-miR-429 FGF12 1.58250682050303 4.75828087352234e-05 -0.170390023502168 0.492844460583921 miRNATAP -0.210203011193729 3.40942510766419e-08 NA NA NA hsa-miR-501-5p FGF12 1.59306197632625 2.04856600619363e-09 -0.170390023502168 0.492844460583921 MirTarget;PITA -0.181286588101594 0.00173309615700133 NA NA NA hsa-miR-511-5p FGF12 0.777051857549583 0.00217788750929907 -0.170390023502168 0.492844460583921 MirTarget -0.25609117829263 1.33100449081888e-05 NA NA NA hsa-miR-576-5p FGF12 0.872721964495849 5.20470410008775e-05 -0.170390023502168 0.492844460583921 mirMAP -0.285894673907094 3.39731423034439e-05 NA NA NA hsa-miR-590-3p FGF12 0.858742926831233 0.000127281269371976 -0.170390023502168 0.492844460583921 mirMAP -0.430578044124979 3.32802035203214e-11 NA NA NA hsa-let-7a-3p FGF13 0.283468597868531 0.127007787220086 -1.30042323380427 5.77730757702532e-05 MirTarget;miRNATAP -0.475244077733442 9.57999273383521e-06 NA NA NA hsa-let-7b-3p FGF13 0.377956364821509 0.0061730103051373 -1.30042323380427 5.77730757702532e-05 MirTarget;miRNATAP -0.732350369739183 4.04650029380768e-07 NA NA NA hsa-let-7f-1-3p FGF13 1.09636075438131 3.42037366931931e-10 -1.30042323380427 5.77730757702532e-05 MirTarget -0.844563222793931 1.69115074147626e-15 NA NA NA hsa-let-7g-3p FGF13 0.784640358146866 0.0110356862897896 -1.30042323380427 5.77730757702532e-05 miRNATAP -0.376627449661093 2.05491488468849e-09 NA NA NA hsa-miR-141-3p FGF13 1.76274853293464 9.99331900755725e-07 -1.30042323380427 5.77730757702532e-05 TargetScan -0.407276395026205 3.08707653685531e-15 NA NA NA hsa-miR-142-5p FGF13 1.08445947321046 0.000126372881543671 -1.30042323380427 5.77730757702532e-05 PITA -0.382856861505224 2.18274830474977e-08 NA NA NA hsa-miR-200a-5p FGF13 2.19152245759943 3.17968183522514e-11 -1.30042323380427 5.77730757702532e-05 MirTarget;miRNATAP -0.440239570416363 1.71891567497667e-15 NA NA NA hsa-miR-200b-5p FGF13 0.934206940937576 0.00554096871767416 -1.30042323380427 5.77730757702532e-05 MirTarget -0.444736980943973 5.67088586939249e-14 NA NA NA hsa-miR-338-5p FGF13 -0.420442436641152 0.0583175290447746 -1.30042323380427 5.77730757702532e-05 PITA -0.391520825303517 1.23846150802499e-05 NA NA NA hsa-miR-421 FGF13 1.26653675546617 2.35180826009926e-08 -1.30042323380427 5.77730757702532e-05 MirTarget;PITA;miRanda;miRNATAP -0.317377972548033 0.000247479122551374 NA NA NA hsa-miR-429 FGF13 1.58250682050303 4.75828087352234e-05 -1.30042323380427 5.77730757702532e-05 miRNATAP -0.330880191588454 2.74290258441633e-11 NA NA NA hsa-miR-455-5p FGF13 0.644390760445571 0.00262275997170695 -1.30042323380427 5.77730757702532e-05 PITA;miRanda -0.387710021040711 2.71621649691694e-05 NA NA NA hsa-miR-493-3p FGF13 1.47683781636643 8.06811473387944e-13 -1.30042323380427 5.77730757702532e-05 MirTarget -0.242748569099383 0.010553005489057 NA NA NA hsa-miR-493-5p FGF13 1.32223598235404 3.01688809960418e-10 -1.30042323380427 5.77730757702532e-05 miRNATAP -0.308180116863126 0.000829434277040122 NA NA NA hsa-miR-511-5p FGF13 0.777051857549583 0.00217788750929907 -1.30042323380427 5.77730757702532e-05 MirTarget -0.402159878537033 1.83283736728348e-07 NA NA NA hsa-miR-539-5p FGF13 0.455406484803261 0.10846447950775 -1.30042323380427 5.77730757702532e-05 miRNATAP -0.241047105417394 0.000753744710051341 NA NA NA hsa-miR-590-3p FGF13 0.858742926831233 0.000127281269371976 -1.30042323380427 5.77730757702532e-05 miRanda -0.567657479913946 3.72819833473931e-11 NA NA NA hsa-miR-7-1-3p FGF13 0.94398354303717 7.5771319809992e-05 -1.30042323380427 5.77730757702532e-05 MirTarget;mirMAP -0.626839783394993 1.92016916094378e-15 NA NA NA hsa-miR-362-3p FGF14 0.994614346444282 4.39793878186399e-05 -1.96265776774443 6.55391090727455e-07 miRanda -0.761763077499395 1.06496806322405e-14 NA NA NA hsa-miR-421 FGF14 1.26653675546617 2.35180826009926e-08 -1.96265776774443 6.55391090727455e-07 miRanda -0.714781000293042 4.24489100701424e-12 NA NA NA hsa-miR-590-3p FGF14 0.858742926831233 0.000127281269371976 -1.96265776774443 6.55391090727455e-07 miRanda -0.879726027606724 1.12384979246171e-17 NA NA NA hsa-miR-96-5p FGF14 1.44821155854693 6.56312590328933e-06 -1.96265776774443 6.55391090727455e-07 TargetScan -0.688539231835716 3.40150969199174e-20 NA NA NA hsa-miR-15a-5p FGF18 1.07800995489566 4.32072598796529e-10 0.577376156575134 0.0408104462212036 miRNATAP -0.283070995407471 0.00368924582522656 NA NA NA hsa-miR-15b-5p FGF18 0.637819606405168 0.000580041575431604 0.577376156575134 0.0408104462212036 miRNATAP -0.380742422390211 3.66375109325843e-05 NA NA NA hsa-miR-16-5p FGF18 0.468459442059375 0.02635007201346 0.577376156575134 0.0408104462212036 miRNATAP -0.369359265698103 5.20931508210512e-06 NA NA NA hsa-miR-200b-3p FGF18 2.06025765178663 3.07718049337497e-10 0.577376156575134 0.0408104462212036 TargetScan -0.105225878046072 0.0394084383165484 NA NA NA hsa-miR-200c-3p FGF18 1.74925752003763 3.42000026705311e-08 0.577376156575134 0.0408104462212036 miRNATAP -0.154304519849012 0.00359233649626805 NA NA NA hsa-miR-326 FGF18 -0.552187708067123 0.039648668341622 0.577376156575134 0.0408104462212036 PITA;miRanda;miRNATAP -0.195670617056415 0.00235356971631403 NA NA NA hsa-miR-330-5p FGF18 0.621676971901542 0.00233177378595631 0.577376156575134 0.0408104462212036 PITA;miRanda;miRNATAP -0.222010766031349 0.00864309903014307 NA NA NA hsa-miR-424-5p FGF18 0.956135912596328 0.00035164943928494 0.577376156575134 0.0408104462212036 miRNATAP -0.165095198242221 0.0099475072854526 NA NA NA hsa-miR-505-3p FGF18 0.68973424635459 0.00225185811813183 0.577376156575134 0.0408104462212036 miRNATAP -0.239412737755368 0.00165382170384001 NA NA NA hsa-miR-590-5p FGF18 0.932604531809045 8.39043954167884e-05 0.577376156575134 0.0408104462212036 miRanda;miRNATAP -0.305535184223753 1.9618146324998e-05 NA NA NA hsa-let-7a-3p FGF2 0.283468597868531 0.127007787220086 -1.0252152469847 2.26010255795334e-05 mirMAP -0.599102067780018 1.05438262026523e-14 NA NA NA hsa-let-7b-3p FGF2 0.377956364821509 0.0061730103051373 -1.0252152469847 2.26010255795334e-05 mirMAP -0.865280608603235 8.8124669093584e-17 NA NA NA hsa-let-7f-1-3p FGF2 1.09636075438131 3.42037366931931e-10 -1.0252152469847 2.26010255795334e-05 mirMAP -0.827295500465144 6.33979037938014e-28 NA NA NA hsa-miR-103a-3p FGF2 1.01322687786547 1.60813894223583e-11 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.524176480381175 3.50701402381341e-08 NA NA NA hsa-miR-107 FGF2 0.85152957824299 1.22369651446858e-11 -1.0252152469847 2.26010255795334e-05 MirTarget;PITA;miRanda;miRNATAP -1.0267513242519 3.37644654811141e-21 NA NA NA hsa-miR-10b-3p FGF2 0.448860145188521 0.00703361939318676 -1.0252152469847 2.26010255795334e-05 mirMAP -0.435178450583106 1.13774805354911e-06 NA NA NA hsa-miR-126-5p FGF2 0.450893496822779 0.0112966412858755 -1.0252152469847 2.26010255795334e-05 mirMAP -0.584227556126462 6.44298056217219e-13 NA NA NA hsa-miR-140-5p FGF2 0.132398579631585 0.457960134430787 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate -0.404952532867132 1.30540321392818e-06 NA NA NA hsa-miR-142-3p FGF2 1.80134804047727 3.87649742898476e-07 -1.0252152469847 2.26010255795334e-05 miRanda -0.311446558782374 1.84906996207043e-15 NA NA NA hsa-miR-142-5p FGF2 1.08445947321046 0.000126372881543671 -1.0252152469847 2.26010255795334e-05 mirMAP -0.377815129670177 4.32950122041185e-14 NA NA NA hsa-miR-144-3p FGF2 -1.37061426401952 5.85913017989725e-05 -1.0252152469847 2.26010255795334e-05 MirTarget -0.195425458231869 7.20949866051114e-06 NA NA NA hsa-miR-146a-5p FGF2 0.801543189433048 0.00411744525146003 -1.0252152469847 2.26010255795334e-05 mirMAP -0.475623312155552 5.51965559855473e-22 NA NA NA hsa-miR-148a-5p FGF2 0.0805913350009586 0.752183008225566 -1.0252152469847 2.26010255795334e-05 mirMAP -0.493378834420424 3.5558122560833e-19 NA NA NA hsa-miR-155-5p FGF2 0.708423342476697 0.00686702252429413 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate;mirMAP -0.378938678037909 5.17046912532486e-12 NA NA NA hsa-miR-15a-5p FGF2 1.07800995489566 4.32072598796529e-10 -1.0252152469847 2.26010255795334e-05 MirTarget;miRNATAP -0.757232397274661 3.65904512887607e-22 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 0.811179945491507 0.000927520880593552 -1.0252152469847 2.26010255795334e-05 mirMAP -0.669511004277745 1.69272813393106e-36 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.637819606405168 0.000580041575431604 -1.0252152469847 2.26010255795334e-05 MirTarget;miRNATAP -0.813464625353685 3.37830314214927e-29 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.23864765632542 1.24544799589822e-08 -1.0252152469847 2.26010255795334e-05 mirMAP -0.646245195146636 2.89800741318362e-24 NA NA NA hsa-miR-16-2-3p FGF2 0.869267463341732 0.000785361809327569 -1.0252152469847 2.26010255795334e-05 mirMAP -0.564751017373064 1.70114216402715e-27 NA NA NA hsa-miR-16-5p FGF2 0.468459442059375 0.02635007201346 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.677411929110591 1.74059869270375e-25 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 1.39352013383959 4.74824377258519e-17 -1.0252152469847 2.26010255795334e-05 mirMAP -0.52916915518647 1.86729809455602e-10 NA NA NA hsa-miR-181b-5p FGF2 1.44365471425231 6.03807007335243e-15 -1.0252152469847 2.26010255795334e-05 mirMAP -0.524465004016153 1.71995957344561e-12 NA NA NA hsa-miR-186-5p FGF2 0.35512789129261 0.0196931838168008 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate;mirMAP -0.811977973846562 3.85805744604828e-18 NA NA NA hsa-miR-192-5p FGF2 2.0867723747501 3.57854249239079e-08 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate -0.350526393312018 4.24849619675693e-23 NA NA NA hsa-miR-19b-1-5p FGF2 1.78323584062047 7.55784857614623e-15 -1.0252152469847 2.26010255795334e-05 mirMAP -0.626395244074512 2.81435701726327e-29 NA NA NA hsa-miR-200b-3p FGF2 2.06025765178663 3.07718049337497e-10 -1.0252152469847 2.26010255795334e-05 mirMAP -0.485657040791614 2.34790149633317e-36 NA NA NA hsa-miR-200c-3p FGF2 1.74925752003763 3.42000026705311e-08 -1.0252152469847 2.26010255795334e-05 mirMAP -0.557894225481938 1.06715375236837e-47 NA NA NA hsa-miR-20a-3p FGF2 0.703027135708586 0.022464856696655 -1.0252152469847 2.26010255795334e-05 mirMAP -0.437650053901768 5.50498828334392e-21 NA NA NA hsa-miR-21-3p FGF2 1.87780012411493 8.38052480155167e-17 -1.0252152469847 2.26010255795334e-05 mirMAP -0.562680774140771 2.39866779667807e-22 NA NA NA hsa-miR-21-5p FGF2 2.21515015440792 6.0468197386674e-49 -1.0252152469847 2.26010255795334e-05 mirMAP -0.539888539504513 1.99056496184664e-11 NA NA NA hsa-miR-215-5p FGF2 1.10296552366805 0.0225256935718223 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate -0.155783067172871 2.66867706821327e-07 NA NA NA hsa-miR-221-3p FGF2 1.11809809289021 6.56903442847056e-08 -1.0252152469847 2.26010255795334e-05 mirMAP -0.692608654249443 4.64224542513337e-27 NA NA NA hsa-miR-222-3p FGF2 1.50650995841483 1.51287294049382e-09 -1.0252152469847 2.26010255795334e-05 mirMAP -0.625052651499674 4.99396376702076e-34 NA NA NA hsa-miR-223-3p FGF2 1.08589180128329 0.000115241553609245 -1.0252152469847 2.26010255795334e-05 MirTarget -0.296362887760396 8.00058219829246e-09 NA NA NA hsa-miR-29a-5p FGF2 1.00715634051951 4.47499137997344e-07 -1.0252152469847 2.26010255795334e-05 mirMAP -0.56657626980705 6.28222282788017e-16 NA NA NA hsa-miR-32-5p FGF2 0.425717775201634 0.0402079308210921 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate -0.636333452404459 2.83843669862663e-21 NA NA NA hsa-miR-330-3p FGF2 0.391166748754241 0.0581284813543685 -1.0252152469847 2.26010255795334e-05 mirMAP -0.443099209633978 1.59282184276266e-09 NA NA NA hsa-miR-335-3p FGF2 2.29463721765513 4.1956113745077e-18 -1.0252152469847 2.26010255795334e-05 mirMAP -0.402802774005505 1.22243908313238e-15 NA NA NA hsa-miR-335-5p FGF2 0.576542642348884 0.01886326850059 -1.0252152469847 2.26010255795334e-05 miRNATAP -0.377162831604711 2.19031698478183e-10 NA NA NA hsa-miR-338-5p FGF2 -0.420442436641152 0.0583175290447746 -1.0252152469847 2.26010255795334e-05 mirMAP -0.196546526372995 0.00373580446836029 NA NA NA hsa-miR-361-5p FGF2 0.538048008019709 1.61165802415302e-07 -1.0252152469847 2.26010255795334e-05 mirMAP -0.675150472223962 3.83892617349459e-06 NA NA NA hsa-miR-369-3p FGF2 0.644921905467686 0.00104986428608648 -1.0252152469847 2.26010255795334e-05 PITA -0.331856563141257 1.11711463916122e-05 NA NA NA hsa-miR-374a-3p FGF2 0.0703956336838676 0.602396227448772 -1.0252152469847 2.26010255795334e-05 mirMAP -0.295707071603743 0.0091742314363648 NA NA NA hsa-miR-374a-5p FGF2 0.239597788731458 0.0202963000797544 -1.0252152469847 2.26010255795334e-05 mirMAP -0.513765959477171 0.000609638341232094 NA NA NA hsa-miR-424-5p FGF2 0.956135912596328 0.00035164943928494 -1.0252152469847 2.26010255795334e-05 MirTarget;miRNATAP -0.421499879130877 1.27085752992381e-15 NA NA NA hsa-miR-429 FGF2 1.58250682050303 4.75828087352234e-05 -1.0252152469847 2.26010255795334e-05 mirMAP -0.403920114780795 2.96435999605169e-32 NA NA NA hsa-miR-450b-5p FGF2 1.36137774989901 7.45499130609203e-11 -1.0252152469847 2.26010255795334e-05 mirMAP -0.447982321632793 2.3575411124667e-11 NA NA NA hsa-miR-452-5p FGF2 0.612108901803716 0.0110020550949664 -1.0252152469847 2.26010255795334e-05 mirMAP -0.21555526577047 0.000499005845710243 NA NA NA hsa-miR-485-3p FGF2 0.974132444962534 1.06350591823177e-05 -1.0252152469847 2.26010255795334e-05 mirMAP -0.189108671337545 0.00499607890244408 NA NA NA hsa-miR-503-5p FGF2 1.76009641313699 2.96580674020209e-09 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate -0.406460111223076 6.16158996470847e-17 NA NA NA hsa-miR-511-5p FGF2 0.777051857549583 0.00217788750929907 -1.0252152469847 2.26010255795334e-05 MirTarget -0.301219795411422 1.83852785810507e-07 NA NA NA hsa-miR-539-5p FGF2 0.455406484803261 0.10846447950775 -1.0252152469847 2.26010255795334e-05 mirMAP -0.139714408246627 0.0094416647728354 NA NA NA hsa-miR-577 FGF2 0.615893340074725 0.210494450869356 -1.0252152469847 2.26010255795334e-05 mirMAP -0.263995487915858 3.43975977455972e-17 NA NA NA hsa-miR-589-3p FGF2 1.00357906465313 8.20399071001461e-05 -1.0252152469847 2.26010255795334e-05 mirMAP -0.492357831870653 1.77325886735645e-17 NA NA NA hsa-miR-590-3p FGF2 0.858742926831233 0.000127281269371976 -1.0252152469847 2.26010255795334e-05 miRanda;mirMAP -0.685144333666873 7.12232422412068e-31 NA NA NA hsa-miR-590-5p FGF2 0.932604531809045 8.39043954167884e-05 -1.0252152469847 2.26010255795334e-05 miRanda;mirMAP -0.585096851588566 2.2863553441064e-24 NA NA NA hsa-miR-92a-3p FGF2 1.06124545165614 6.51550014372282e-08 -1.0252152469847 2.26010255795334e-05 miRNAWalker2_validate -0.721792973300204 2.74374608972338e-26 NA NA NA hsa-miR-93-3p FGF2 1.18510939268904 1.19856269043125e-06 -1.0252152469847 2.26010255795334e-05 mirMAP -0.590321275274342 3.09130864556897e-27 NA NA NA hsa-let-7a-3p FGF5 0.283468597868531 0.127007787220086 0.549344799655697 0.286593917342756 mirMAP -1.12910444554696 6.82961145160299e-12 NA NA NA hsa-let-7b-3p FGF5 0.377956364821509 0.0061730103051373 0.549344799655697 0.286593917342756 mirMAP -1.22117819929279 7.06007704168695e-08 NA NA NA hsa-let-7f-1-3p FGF5 1.09636075438131 3.42037366931931e-10 0.549344799655697 0.286593917342756 mirMAP -0.877846851503235 3.71691629063681e-07 NA NA NA hsa-miR-126-5p FGF5 0.450893496822779 0.0112966412858755 0.549344799655697 0.286593917342756 mirMAP -0.923679420957607 1.17104001270778e-07 NA NA NA hsa-miR-132-3p FGF5 0.615446256559387 1.70100472454261e-06 0.549344799655697 0.286593917342756 mirMAP -0.636079496382253 0.00959533768472606 NA NA NA hsa-miR-155-5p FGF5 0.708423342476697 0.00686702252429413 0.549344799655697 0.286593917342756 mirMAP -0.736546697435224 2.20926035002411e-10 NA NA NA hsa-miR-15b-5p FGF5 0.637819606405168 0.000580041575431604 0.549344799655697 0.286593917342756 miRNAWalker2_validate -1.22253464486553 4.38757175264279e-14 NA NA NA hsa-miR-16-1-3p FGF5 1.23864765632542 1.24544799589822e-08 0.549344799655697 0.286593917342756 mirMAP -0.964020182065746 6.75178535361349e-12 NA NA NA hsa-miR-17-5p FGF5 1.57209612312313 5.10453838016207e-11 0.549344799655697 0.286593917342756 TargetScan -0.699683628235523 1.69406179459224e-08 NA NA NA hsa-miR-212-3p FGF5 0.810640598956005 2.08058512206955e-06 0.549344799655697 0.286593917342756 mirMAP -0.754511556059802 3.03945528151731e-05 NA NA NA hsa-miR-30b-5p FGF5 -0.0106833209203501 0.954966272944722 0.549344799655697 0.286593917342756 mirMAP -0.837479205696301 3.9352459273209e-07 NA NA NA hsa-miR-30c-5p FGF5 -0.172645077009891 0.276411433016536 0.549344799655697 0.286593917342756 mirMAP -0.775048589044877 0.000104727059460579 NA NA NA hsa-miR-30d-5p FGF5 0.26829866064717 0.0228954180095085 0.549344799655697 0.286593917342756 mirMAP -1.2680326356604 2.65079351413692e-06 NA NA NA hsa-miR-30e-5p FGF5 -0.284839730810255 0.0405852891523165 0.549344799655697 0.286593917342756 mirMAP -2.03148886244201 1.47839904561096e-21 NA NA NA hsa-miR-331-5p FGF5 0.703863188605486 4.25406757208802e-05 0.549344799655697 0.286593917342756 PITA -0.882584603796651 9.8711961253166e-07 NA NA NA hsa-miR-335-3p FGF5 2.29463721765513 4.1956113745077e-18 0.549344799655697 0.286593917342756 mirMAP -0.457808914357202 3.35208797374043e-05 NA NA NA hsa-miR-338-3p FGF5 -0.0138760121093551 0.956163634155272 0.549344799655697 0.286593917342756 miRanda -0.340011624184362 0.0066083570419513 NA NA NA hsa-miR-33a-3p FGF5 0.21453033253985 0.371591474252951 0.549344799655697 0.286593917342756 mirMAP -0.861723942655226 1.01203038155025e-10 NA NA NA hsa-miR-340-5p FGF5 0.344103676703511 0.0160638942614091 0.549344799655697 0.286593917342756 mirMAP -0.753554352075746 0.000704603402073608 NA NA NA hsa-miR-3607-3p FGF5 0.479939234340415 0.251616873367277 0.549344799655697 0.286593917342756 miRNATAP -0.317256378647853 3.55913684850443e-05 NA NA NA hsa-miR-361-5p FGF5 0.538048008019709 1.61165802415302e-07 0.549344799655697 0.286593917342756 miRanda -0.797889724754 0.0103244345806952 NA NA NA hsa-miR-369-3p FGF5 0.644921905467686 0.00104986428608648 0.549344799655697 0.286593917342756 miRNATAP -0.352237337442561 0.0284540166071851 NA NA NA hsa-miR-374a-5p FGF5 0.239597788731458 0.0202963000797544 0.549344799655697 0.286593917342756 mirMAP -1.19223881013095 0.000145764937959499 NA NA NA hsa-miR-374b-5p FGF5 0.00249900187478502 0.985380083859555 0.549344799655697 0.286593917342756 mirMAP -0.766054279611005 0.0011243367752784 NA NA NA hsa-miR-425-5p FGF5 0.865319550452351 0.000902803064763851 0.549344799655697 0.286593917342756 mirMAP -0.808833659898365 2.31669602925912e-12 NA NA NA hsa-miR-455-5p FGF5 0.644390760445571 0.00262275997170695 0.549344799655697 0.286593917342756 miRanda -1.00829815150019 8.03934388290164e-13 NA NA NA hsa-miR-486-5p FGF5 -1.52128065772506 4.50915908626354e-09 0.549344799655697 0.286593917342756 miRanda -0.478254682050139 4.28906717966062e-05 NA NA NA hsa-miR-500a-5p FGF5 1.33126717816499 3.1497328652235e-07 0.549344799655697 0.286593917342756 mirMAP -0.754004835726871 4.53200930638844e-11 NA NA NA hsa-miR-501-5p FGF5 1.59306197632625 2.04856600619363e-09 0.549344799655697 0.286593917342756 PITA;mirMAP -0.724222560312587 6.2101099921801e-10 NA NA NA hsa-miR-577 FGF5 0.615893340074725 0.210494450869356 0.549344799655697 0.286593917342756 miRNATAP -0.331129992361835 1.44080596254466e-06 NA NA NA hsa-miR-590-3p FGF5 0.858742926831233 0.000127281269371976 0.549344799655697 0.286593917342756 miRanda;mirMAP;miRNATAP -1.04282008224063 3.96671088401118e-15 NA NA NA hsa-miR-7-1-3p FGF5 0.94398354303717 7.5771319809992e-05 0.549344799655697 0.286593917342756 mirMAP -0.897024234821736 8.54706108170611e-13 NA NA NA hsa-let-7a-3p FGF7 0.283468597868531 0.127007787220086 -0.41434019544902 0.185809734564159 MirTarget;miRNATAP -0.632596548863359 3.32676154537638e-10 NA NA NA hsa-let-7b-3p FGF7 0.377956364821509 0.0061730103051373 -0.41434019544902 0.185809734564159 MirTarget;miRNATAP -0.881494585965934 9.09850155275689e-11 NA NA NA hsa-let-7f-1-3p FGF7 1.09636075438131 3.42037366931931e-10 -0.41434019544902 0.185809734564159 MirTarget -0.866499912121205 5.716443491951e-18 NA NA NA hsa-miR-107 FGF7 0.85152957824299 1.22369651446858e-11 -0.41434019544902 0.185809734564159 PITA;miRanda;miRNATAP -1.24232922317537 6.6069341703776e-19 NA NA NA hsa-miR-126-5p FGF7 0.450893496822779 0.0112966412858755 -0.41434019544902 0.185809734564159 miRNATAP -0.472229618526538 9.74624463909161e-06 NA NA NA hsa-miR-140-5p FGF7 0.132398579631585 0.457960134430787 -0.41434019544902 0.185809734564159 miRanda -0.356939157023616 0.000949791624917192 NA NA NA hsa-miR-142-5p FGF7 1.08445947321046 0.000126372881543671 -0.41434019544902 0.185809734564159 PITA;mirMAP -0.266691176918927 5.74389083052192e-05 NA NA NA hsa-miR-155-5p FGF7 0.708423342476697 0.00686702252429413 -0.41434019544902 0.185809734564159 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.32699153156563 5.28065147489088e-06 NA NA NA hsa-miR-15a-5p FGF7 1.07800995489566 4.32072598796529e-10 -0.41434019544902 0.185809734564159 miRTarBase;miRNATAP -0.941433245775327 6.05048122645589e-21 NA NA NA hsa-miR-15b-5p FGF7 0.637819606405168 0.000580041575431604 -0.41434019544902 0.185809734564159 miRNATAP -1.05554030818667 1.89390228431205e-30 NA NA NA hsa-miR-16-1-3p FGF7 1.23864765632542 1.24544799589822e-08 -0.41434019544902 0.185809734564159 mirMAP -0.780000042905683 1.95717418209924e-21 NA NA NA hsa-miR-16-2-3p FGF7 0.869267463341732 0.000785361809327569 -0.41434019544902 0.185809734564159 mirMAP -0.645433902621074 2.15911656644995e-21 NA NA NA hsa-miR-16-5p FGF7 0.468459442059375 0.02635007201346 -0.41434019544902 0.185809734564159 miRNATAP -0.821178064931021 1.07301219125421e-22 NA NA NA hsa-miR-18a-3p FGF7 1.42489363201958 4.87914808744785e-05 -0.41434019544902 0.185809734564159 MirTarget -0.492405147771168 3.2017279506033e-18 NA NA NA hsa-miR-192-3p FGF7 1.78627547479709 3.23498378613139e-06 -0.41434019544902 0.185809734564159 mirMAP -0.362050473092052 6.67698220230567e-15 NA NA NA hsa-miR-20a-5p FGF7 1.57190995476158 8.72275528729458e-12 -0.41434019544902 0.185809734564159 miRNAWalker2_validate -0.612841635241527 5.91832060059371e-16 NA NA NA hsa-miR-223-5p FGF7 0.814299470198797 0.00250546576879879 -0.41434019544902 0.185809734564159 mirMAP -0.157226709740591 0.0308491223124629 NA NA NA hsa-miR-26b-5p FGF7 -0.499493687076043 0.0118149973400486 -0.41434019544902 0.185809734564159 mirMAP -0.537213052288076 1.25498943369619e-08 NA NA NA hsa-miR-27a-3p FGF7 0.523219911315699 0.000116410279757859 -0.41434019544902 0.185809734564159 MirTarget -0.809293407290616 4.97076252665022e-09 NA NA NA hsa-miR-30d-3p FGF7 0.0608340295673737 0.708110230223927 -0.41434019544902 0.185809734564159 miRNATAP -0.773063482787725 1.96735059623387e-11 NA NA NA hsa-miR-320a FGF7 0.451741078692272 0.00893327237386749 -0.41434019544902 0.185809734564159 miRanda -0.441297086470752 6.42355955362713e-05 NA NA NA hsa-miR-320b FGF7 1.21733873788625 7.99882585998487e-07 -0.41434019544902 0.185809734564159 miRanda -0.496433825834704 1.37216054225704e-11 NA NA NA hsa-miR-33a-3p FGF7 0.21453033253985 0.371591474252951 -0.41434019544902 0.185809734564159 mirMAP -0.601060517606801 5.28683992593728e-14 NA NA NA hsa-miR-3607-3p FGF7 0.479939234340415 0.251616873367277 -0.41434019544902 0.185809734564159 mirMAP -0.214330303551095 3.92112456887816e-06 NA NA NA hsa-miR-361-5p FGF7 0.538048008019709 1.61165802415302e-07 -0.41434019544902 0.185809734564159 PITA;miRanda;miRNATAP -0.699226034727084 0.000195227197341577 NA NA NA hsa-miR-374a-3p FGF7 0.0703956336838676 0.602396227448772 -0.41434019544902 0.185809734564159 miRNATAP -0.315717818532644 0.02949294847641 NA NA NA hsa-miR-421 FGF7 1.26653675546617 2.35180826009926e-08 -0.41434019544902 0.185809734564159 miRanda -0.58352478380826 2.44547457811564e-13 NA NA NA hsa-miR-424-5p FGF7 0.956135912596328 0.00035164943928494 -0.41434019544902 0.185809734564159 miRNATAP -0.386651591074064 2.40329549793218e-08 NA NA NA hsa-miR-429 FGF7 1.58250682050303 4.75828087352234e-05 -0.41434019544902 0.185809734564159 miRNATAP -0.443177881879602 1.32873127787706e-22 NA NA NA hsa-miR-455-3p FGF7 1.12209231899143 0.00131487017648489 -0.41434019544902 0.185809734564159 PITA;miRNATAP -0.492462589361744 6.27060695747899e-23 NA NA NA hsa-miR-484 FGF7 0.401753773460753 0.0490851523101605 -0.41434019544902 0.185809734564159 PITA -0.699203507277423 5.49197938827255e-15 NA NA NA hsa-miR-486-5p FGF7 -1.52128065772506 4.50915908626354e-09 -0.41434019544902 0.185809734564159 MirTarget;miRanda -0.245969863114941 0.000565640960854687 NA NA NA hsa-miR-501-5p FGF7 1.59306197632625 2.04856600619363e-09 -0.41434019544902 0.185809734564159 PITA;mirMAP -0.569560827156159 1.93723030709362e-16 NA NA NA hsa-miR-508-3p FGF7 1.53768798407171 1.87828031023414e-05 -0.41434019544902 0.185809734564159 PITA;miRNATAP -0.207245456857756 0.000200169826916195 NA NA NA hsa-miR-577 FGF7 0.615893340074725 0.210494450869356 -0.41434019544902 0.185809734564159 PITA;mirMAP -0.328985530842253 2.21761317958931e-16 NA NA NA hsa-miR-590-3p FGF7 0.858742926831233 0.000127281269371976 -0.41434019544902 0.185809734564159 PITA;miRanda;mirMAP;miRNATAP -0.719441188494751 9.69506325087792e-20 NA NA NA hsa-miR-590-5p FGF7 0.932604531809045 8.39043954167884e-05 -0.41434019544902 0.185809734564159 PITA;miRanda -0.636897792181288 3.08757564518187e-17 NA NA NA hsa-miR-7-1-3p FGF7 0.94398354303717 7.5771319809992e-05 -0.41434019544902 0.185809734564159 mirMAP -0.706024298948919 6.52589843276285e-22 NA NA NA hsa-miR-142-3p FGF9 1.80134804047727 3.87649742898476e-07 -0.567473807130705 0.17094770957627 miRanda -0.185605549295511 0.00774521145765681 NA NA NA hsa-miR-142-5p FGF9 1.08445947321046 0.000126372881543671 -0.567473807130705 0.17094770957627 mirMAP -0.293713862569243 0.000867564155028377 NA NA NA hsa-miR-155-5p FGF9 0.708423342476697 0.00686702252429413 -0.567473807130705 0.17094770957627 miRNATAP -0.323837112604256 0.000735733632731601 NA NA NA hsa-miR-15a-5p FGF9 1.07800995489566 4.32072598796529e-10 -0.567473807130705 0.17094770957627 miRNATAP -0.322601590029083 0.024431242421123 NA NA NA hsa-miR-15b-5p FGF9 0.637819606405168 0.000580041575431604 -0.567473807130705 0.17094770957627 miRNATAP -0.348214025741738 0.0107764101094491 NA NA NA hsa-miR-16-2-3p FGF9 0.869267463341732 0.000785361809327569 -0.567473807130705 0.17094770957627 mirMAP -0.295018033125319 0.00234505240948634 NA NA NA hsa-miR-16-5p FGF9 0.468459442059375 0.02635007201346 -0.567473807130705 0.17094770957627 miRNATAP -0.292368075720853 0.0152643987915688 NA NA NA hsa-miR-183-5p FGF9 2.08412478942637 1.08931431254487e-10 -0.567473807130705 0.17094770957627 miRNATAP -0.159412935830117 0.035330980163184 NA NA NA hsa-miR-330-5p FGF9 0.621676971901542 0.00233177378595631 -0.567473807130705 0.17094770957627 miRanda;miRNATAP -0.328086145109636 0.00810673884314231 NA NA NA hsa-miR-338-5p FGF9 -0.420442436641152 0.0583175290447746 -0.567473807130705 0.17094770957627 miRNATAP -0.261267105758903 0.0228772380985915 NA NA NA hsa-miR-582-5p FGF9 0.0720675907490005 0.728284850619144 -0.567473807130705 0.17094770957627 miRNATAP -0.552776508966819 5.30075679888642e-06 NA NA NA hsa-miR-590-3p FGF9 0.858742926831233 0.000127281269371976 -0.567473807130705 0.17094770957627 miRanda;mirMAP -0.284065013199177 0.0115200156500207 NA NA NA hsa-miR-590-5p FGF9 0.932604531809045 8.39043954167884e-05 -0.567473807130705 0.17094770957627 miRanda -0.239427920013799 0.0241877137723657 NA NA NA hsa-miR-106a-5p FGFR1 0.587427028487119 0.00838999163993323 -0.509147194592856 0.0395673749466621 mirMAP -0.269763431432149 6.15055310553859e-05 NA NA NA hsa-miR-106b-5p FGFR1 1.08518388423396 4.82746923373852e-09 -0.509147194592856 0.0395673749466621 mirMAP -0.648636392837168 5.2163842198511e-18 NA NA NA hsa-miR-135b-5p FGFR1 2.80066701698235 2.12546333413447e-11 -0.509147194592856 0.0395673749466621 mirMAP -0.244732054611306 2.712797418494e-12 NA NA NA hsa-miR-15a-5p FGFR1 1.07800995489566 4.32072598796529e-10 -0.509147194592856 0.0395673749466621 miRNATAP -0.783019415882119 2.13146372660076e-23 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 0.637819606405168 0.000580041575431604 -0.509147194592856 0.0395673749466621 miRNATAP -0.648002561038327 3.47431371784711e-17 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.468459442059375 0.02635007201346 -0.509147194592856 0.0395673749466621 miRTarBase;miRNATAP -0.537128465186198 3.99987589014271e-15 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 1.57209612312313 5.10453838016207e-11 -0.509147194592856 0.0395673749466621 mirMAP -0.51732374635906 1.01412674874412e-19 NA NA NA hsa-miR-181b-5p FGFR1 1.44365471425231 6.03807007335243e-15 -0.509147194592856 0.0395673749466621 miRNAWalker2_validate -0.361376189596131 2.687071381843e-06 NA NA NA hsa-miR-200a-5p FGFR1 2.19152245759943 3.17968183522514e-11 -0.509147194592856 0.0395673749466621 mirMAP -0.427601362492559 9.35731650238562e-27 NA NA NA hsa-miR-200b-5p FGFR1 0.934206940937576 0.00554096871767416 -0.509147194592856 0.0395673749466621 mirMAP -0.423394108592067 1.02354067838638e-22 NA NA NA hsa-miR-20a-5p FGFR1 1.57190995476158 8.72275528729458e-12 -0.509147194592856 0.0395673749466621 mirMAP -0.533919040580443 1.57853121158839e-19 NA NA NA hsa-miR-301a-3p FGFR1 1.22580753116505 5.84016077664577e-09 -0.509147194592856 0.0395673749466621 mirMAP -0.409481105244589 1.99081884913885e-09 NA NA NA hsa-miR-326 FGFR1 -0.552187708067123 0.039648668341622 -0.509147194592856 0.0395673749466621 miRanda;miRNATAP -0.113606769373743 0.0449021033161749 NA NA NA hsa-miR-330-3p FGFR1 0.391166748754241 0.0581284813543685 -0.509147194592856 0.0395673749466621 PITA;miRNATAP -0.339768236808415 6.29886905926343e-06 NA NA NA hsa-miR-330-5p FGFR1 0.621676971901542 0.00233177378595631 -0.509147194592856 0.0395673749466621 miRanda;miRNATAP -0.429325548265909 2.62893962525293e-09 NA NA NA hsa-miR-335-3p FGFR1 2.29463721765513 4.1956113745077e-18 -0.509147194592856 0.0395673749466621 mirMAP -0.332726927564988 1.43917473868514e-10 NA NA NA hsa-miR-361-5p FGFR1 0.538048008019709 1.61165802415302e-07 -0.509147194592856 0.0395673749466621 miRanda -0.307141757969083 0.040493907588941 NA NA NA hsa-miR-424-5p FGFR1 0.956135912596328 0.00035164943928494 -0.509147194592856 0.0395673749466621 miRNAWalker2_validate;miRTarBase;miRNATAP -0.246292911747519 8.84714292243765e-06 NA NA NA hsa-miR-455-5p FGFR1 0.644390760445571 0.00262275997170695 -0.509147194592856 0.0395673749466621 miRanda -0.493958377938575 2.67062271531024e-13 NA NA NA hsa-miR-532-5p FGFR1 1.45407925817457 1.88450871132345e-14 -0.509147194592856 0.0395673749466621 PITA -0.627220930088032 1.58241704586078e-18 NA NA NA hsa-miR-577 FGFR1 0.615893340074725 0.210494450869356 -0.509147194592856 0.0395673749466621 PITA;mirMAP -0.205272931421074 2.78392560554546e-10 NA NA NA hsa-miR-590-3p FGFR1 0.858742926831233 0.000127281269371976 -0.509147194592856 0.0395673749466621 miRanda;mirMAP -0.571940084079922 6.21900314288353e-20 NA NA NA hsa-miR-744-5p FGFR1 0.734924181943417 2.06706878377701e-05 -0.509147194592856 0.0395673749466621 miRNAWalker2_validate -0.585881226150112 2.93667136582691e-12 NA NA NA hsa-miR-93-5p FGFR1 1.68243825551104 4.62947431501061e-15 -0.509147194592856 0.0395673749466621 mirMAP -0.539985354627494 1.09075089597807e-17 NA NA NA hsa-let-7f-1-3p FGFR2 1.09636075438131 3.42037366931931e-10 -0.156555544338333 0.593224411105429 mirMAP -0.216874347145933 0.0301478470371062 NA NA NA hsa-miR-126-5p FGFR2 0.450893496822779 0.0112966412858755 -0.156555544338333 0.593224411105429 mirMAP;miRNATAP -0.209898840646709 0.0381232113851426 NA NA NA hsa-miR-186-5p FGFR2 0.35512789129261 0.0196931838168008 -0.156555544338333 0.593224411105429 miRNAWalker2_validate -0.289428347921334 0.0149064331360931 NA NA NA hsa-miR-19b-1-5p FGFR2 1.78323584062047 7.55784857614623e-15 -0.156555544338333 0.593224411105429 miRNAWalker2_validate;miRTarBase -0.208080044488988 0.00494605831272806 NA NA NA hsa-miR-369-3p FGFR2 0.644921905467686 0.00104986428608648 -0.156555544338333 0.593224411105429 miRNATAP -0.253388421529996 0.00537149284939825 NA NA NA hsa-miR-423-3p FGFR2 1.0646553568956 2.48410617381049e-08 -0.156555544338333 0.593224411105429 PITA;miRNATAP -0.243202068000953 0.00803439574699278 NA NA NA hsa-miR-542-3p FGFR2 1.12416854979951 1.02649534578738e-12 -0.156555544338333 0.593224411105429 miRanda -0.322659990069579 0.00321313394345986 NA NA NA hsa-miR-590-3p FGFR2 0.858742926831233 0.000127281269371976 -0.156555544338333 0.593224411105429 miRanda -0.200327653764979 0.0115864464132015 NA NA NA hsa-miR-940 FGFR2 1.3080677738253 2.0056085433599e-05 -0.156555544338333 0.593224411105429 miRNATAP -0.138390498188795 0.0192308762004965 NA NA NA hsa-miR-100-5p FGFR3 -0.343735526262058 0.133995182819209 0.412481439231821 0.23564742814636 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.24410086338611 0.00862401609581521 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-19b-3p FLT1 0.936987029203338 9.28141970787798e-06 0.57568340419435 6.23591985496983e-05 MirTarget -0.109511607177097 0.0083701009208693 NA NA NA hsa-miR-29a-5p FLT1 1.00715634051951 4.47499137997344e-07 0.57568340419435 6.23591985496983e-05 MirTarget -0.127532933111562 0.00355064442888491 NA NA NA hsa-miR-335-5p FLT3 0.576542642348884 0.01886326850059 -1.05472974254541 0.000879765834588404 miRNAWalker2_validate -0.289839056981883 0.000261450650305064 NA NA NA hsa-miR-590-3p FLT3 0.858742926831233 0.000127281269371976 -1.05472974254541 0.000879765834588404 PITA;miRanda;mirMAP;miRNATAP -0.184331392661723 0.0338905245207436 NA NA NA hsa-miR-429 FLT4 1.58250682050303 4.75828087352234e-05 0.46345682242261 0.00258343277793597 miRanda;miRNATAP -0.119332169493176 5.60614461431518e-07 NA NA NA hsa-let-7g-5p FN1 0.296128761926282 0.0296823495976068 1.63571508215028 7.95640379222503e-08 miRTarBase -0.843408827075864 1.18065405160523e-09 NA NA NA hsa-miR-144-3p FN1 -1.37061426401952 5.85913017989725e-05 1.63571508215028 7.95640379222503e-08 MirTarget -0.306157715219852 2.39889415254074e-08 NA NA NA hsa-miR-16-1-3p FN1 1.23864765632542 1.24544799589822e-08 1.63571508215028 7.95640379222503e-08 mirMAP -0.307456958067701 0.000475572213222431 NA NA NA hsa-miR-200b-3p FN1 2.06025765178663 3.07718049337497e-10 1.63571508215028 7.95640379222503e-08 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.370936995941682 7.92466179566393e-12 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 1.74925752003763 3.42000026705311e-08 1.63571508215028 7.95640379222503e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.368144262432003 8.60411533335839e-11 NA NA NA hsa-miR-26b-5p FN1 -0.499493687076043 0.0118149973400486 1.63571508215028 7.95640379222503e-08 miRNAWalker2_validate -0.603227031099898 1.04358948438635e-10 NA NA NA hsa-miR-27a-5p FN1 0.59763448976729 0.00736257811879899 1.63571508215028 7.95640379222503e-08 MirTarget -0.199701112668492 0.0197566534097704 NA NA NA hsa-miR-27b-3p FN1 -0.439806942644624 0.000523870009254693 1.63571508215028 7.95640379222503e-08 MirTarget -0.347885116170337 0.022928436417629 NA NA NA hsa-miR-320b FN1 1.21733873788625 7.99882585998487e-07 1.63571508215028 7.95640379222503e-08 miRanda -0.180006689746104 0.0179882026828957 NA NA NA hsa-miR-33a-3p FN1 0.21453033253985 0.371591474252951 1.63571508215028 7.95640379222503e-08 mirMAP -0.454464281109067 2.58653886748503e-08 NA NA NA hsa-miR-429 FN1 1.58250682050303 4.75828087352234e-05 1.63571508215028 7.95640379222503e-08 MirTarget;PITA;miRanda;miRNATAP -0.33343088674574 1.48358464174805e-12 NA NA NA hsa-miR-590-3p FN1 0.858742926831233 0.000127281269371976 1.63571508215028 7.95640379222503e-08 miRanda;mirMAP -0.473371053797533 1.02523938848468e-08 NA NA NA hsa-miR-96-5p FN1 1.44821155854693 6.56312590328933e-06 1.63571508215028 7.95640379222503e-08 MirTarget;TargetScan -0.284475877093208 3.65711112462415e-06 NA NA NA hsa-let-7a-3p FOXO3 0.283468597868531 0.127007787220086 -0.0400929851881102 0.720284180374582 mirMAP;miRNATAP -0.154277651863847 2.36417448230553e-05 NA NA NA hsa-let-7b-3p FOXO3 0.377956364821509 0.0061730103051373 -0.0400929851881102 0.720284180374582 mirMAP;miRNATAP -0.12217941551635 0.0144853298223762 NA NA NA hsa-miR-126-5p FOXO3 0.450893496822779 0.0112966412858755 -0.0400929851881102 0.720284180374582 mirMAP -0.137715246891691 0.000307596931945236 NA NA NA hsa-miR-155-5p FOXO3 0.708423342476697 0.00686702252429413 -0.0400929851881102 0.720284180374582 miRNAWalker2_validate;miRTarBase -0.149037327726078 3.1897499000475e-09 27596294;25480585;20371610;26398931;22027557;27107135 MiR-155 targets 3´UTR region of multiple components of the pro-oncogenic signaling cascades including FOXO3a tumor suppressor and RUNX2 transcription factor regulating metastatic potential in BC;The effect of miRNA155 on FOXO3a expression was examined by Western blotting; FOXO3a was found to be a possible target of miRNA155 as suggested by Targetscan website;MicroRNA 155 regulates cell survival growth and chemosensitivity by targeting FOXO3a in breast cancer; In this study we demonstrate the critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer; Further we identified FOXO3a as a direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of FOXO3a protein without changing mRNA levels and knockdown of miR-155 increases FOXO3a; Finally inverse correlation between miR-155 and FOXO3a levels were observed in a panel of breast cancer cell lines and tumors; In conclusion our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer;In contrast downregulation of miR-155-5p increased sensitivity to bufalin and upregulated the expression of FOXO3A;Here we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target FOXO3A;Our results further revealed that forkhead box O3a FoxO3a was a miR-155 target in the heart; And miR-155 directly repressed FoxO3a whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro ;;poor survival;;; breast cancer;lymphoma;breast cancer;breast cancer;lung cancer;breast cancer hsa-miR-26a-5p FOXO3 -0.507487084157331 3.23715933371269e-05 -0.0400929851881102 0.720284180374582 miRNAWalker2_validate -0.141756457207582 0.011822463488936 NA NA NA hsa-miR-27a-3p FOXO3 0.523219911315699 0.000116410279757859 -0.0400929851881102 0.720284180374582 miRNATAP -0.206002554258992 3.7249476513434e-05 23621269 FOXO3a was verified as a new target of miR-27a by Western blotting and reporter analyzes glioblastoma hsa-miR-28-3p FOXO3 -0.247525872199168 0.0399632425440147 -0.0400929851881102 0.720284180374582 PITA;miRNATAP -0.14457099944566 0.0124551344770011 NA NA NA hsa-miR-28-5p FOXO3 -0.22318016376076 0.0194144033008573 -0.0400929851881102 0.720284180374582 PITA;miRNATAP -0.180166529859564 0.015475136329197 NA NA NA hsa-miR-29a-3p FOXO3 -0.235052170104117 0.138527567930958 -0.0400929851881102 0.720284180374582 miRNATAP -0.198193222245734 3.64044669272419e-06 NA NA NA hsa-miR-29a-5p FOXO3 1.00715634051951 4.47499137997344e-07 -0.0400929851881102 0.720284180374582 mirMAP -0.152801030465765 3.83770686295095e-06 NA NA NA hsa-miR-29b-3p FOXO3 0.0225365195743876 0.914313337784307 -0.0400929851881102 0.720284180374582 miRNATAP -0.149292005933619 3.63805520158727e-06 NA NA NA hsa-miR-361-3p FOXO3 0.485361250955594 0.00074097948047418 -0.0400929851881102 0.720284180374582 miRNATAP -0.110567603813351 0.0204456288190035 NA NA NA hsa-miR-454-3p FOXO3 0.823770738595667 1.30339728183332e-05 -0.0400929851881102 0.720284180374582 mirMAP -0.140268102524508 7.31558573766185e-05 NA NA NA hsa-miR-576-5p FOXO3 0.872721964495849 5.20470410008775e-05 -0.0400929851881102 0.720284180374582 mirMAP -0.124876960891762 5.48599183973629e-05 NA NA NA hsa-miR-582-3p FOXO3 -0.104548775434833 0.640423116430294 -0.0400929851881102 0.720284180374582 PITA;miRNATAP -0.108499907002334 0.000353292778398097 NA NA NA hsa-miR-590-3p FOXO3 0.858742926831233 0.000127281269371976 -0.0400929851881102 0.720284180374582 PITA;miRanda;mirMAP;miRNATAP -0.147164353068806 6.91336337568251e-07 NA NA NA hsa-miR-590-5p FOXO3 0.932604531809045 8.39043954167884e-05 -0.0400929851881102 0.720284180374582 miRanda -0.118100297033414 2.74167348861697e-05 NA NA NA hsa-let-7a-5p GHR 0.298659498236324 0.00963231738125113 -2.14662589752822 3.10775498765719e-12 TargetScan;miRNATAP -0.452922308695811 0.00952908798709956 NA NA NA hsa-let-7b-5p GHR 0.16896311055967 0.160596228583843 -2.14662589752822 3.10775498765719e-12 miRNATAP -0.418198413782441 0.012663195044331 NA NA NA hsa-let-7f-5p GHR 0.300925310468863 0.0221019558342241 -2.14662589752822 3.10775498765719e-12 miRNATAP -0.574344619304167 0.000144685941506488 NA NA NA hsa-let-7g-5p GHR 0.296128761926282 0.0296823495976068 -2.14662589752822 3.10775498765719e-12 miRNATAP -1.23334291925271 2.24647527812645e-19 NA NA NA hsa-let-7i-5p GHR 0.90895826823783 5.79676789748755e-17 -2.14662589752822 3.10775498765719e-12 miRNATAP -0.784323509603072 5.77541467828296e-06 NA NA NA hsa-miR-126-5p GHR 0.450893496822779 0.0112966412858755 -2.14662589752822 3.10775498765719e-12 MirTarget;mirMAP -0.583730791698355 7.8557055126874e-08 NA NA NA hsa-miR-142-3p GHR 1.80134804047727 3.87649742898476e-07 -2.14662589752822 3.10775498765719e-12 MirTarget;PITA;miRanda;miRNATAP -0.374405710573745 5.02786676572617e-13 NA NA NA hsa-miR-15a-5p GHR 1.07800995489566 4.32072598796529e-10 -2.14662589752822 3.10775498765719e-12 MirTarget;miRNATAP -1.11193091490982 6.97459730483786e-29 NA NA NA hsa-miR-15b-5p GHR 0.637819606405168 0.000580041575431604 -2.14662589752822 3.10775498765719e-12 MirTarget;miRNATAP -1.12704817159148 1.45717374806069e-33 NA NA NA hsa-miR-16-2-3p GHR 0.869267463341732 0.000785361809327569 -2.14662589752822 3.10775498765719e-12 mirMAP -0.738703697026994 2.06866006497386e-27 NA NA NA hsa-miR-16-5p GHR 0.468459442059375 0.02635007201346 -2.14662589752822 3.10775498765719e-12 MirTarget;miRNATAP -0.858253112380564 1.28699187367759e-23 NA NA NA hsa-miR-29a-5p GHR 1.00715634051951 4.47499137997344e-07 -2.14662589752822 3.10775498765719e-12 mirMAP;miRNATAP -0.869241084697873 2.4202821283958e-22 NA NA NA hsa-miR-338-5p GHR -0.420442436641152 0.0583175290447746 -2.14662589752822 3.10775498765719e-12 PITA -0.245859557868167 0.00564973723338071 NA NA NA hsa-miR-33a-3p GHR 0.21453033253985 0.371591474252951 -2.14662589752822 3.10775498765719e-12 miRNATAP -0.639900125216104 4.67633321060339e-15 NA NA NA hsa-miR-3607-3p GHR 0.479939234340415 0.251616873367277 -2.14662589752822 3.10775498765719e-12 mirMAP -0.241089002862128 3.83257109337274e-07 NA NA NA hsa-miR-361-5p GHR 0.538048008019709 1.61165802415302e-07 -2.14662589752822 3.10775498765719e-12 miRanda -0.982876596560269 2.46037835360532e-07 NA NA NA hsa-miR-409-3p GHR 1.02296003511803 1.54748197930307e-08 -2.14662589752822 3.10775498765719e-12 PITA -0.307593656048962 0.0038402637924025 NA NA NA hsa-miR-421 GHR 1.26653675546617 2.35180826009926e-08 -2.14662589752822 3.10775498765719e-12 miRanda -0.671247816520578 8.78525508931327e-17 NA NA NA hsa-miR-424-5p GHR 0.956135912596328 0.00035164943928494 -2.14662589752822 3.10775498765719e-12 MirTarget;miRNATAP -0.484921708251533 4.44821308191154e-12 NA NA NA hsa-miR-429 GHR 1.58250682050303 4.75828087352234e-05 -2.14662589752822 3.10775498765719e-12 miRanda;miRNATAP -0.497681913938195 8.66794671372272e-28 NA NA NA hsa-miR-455-5p GHR 0.644390760445571 0.00262275997170695 -2.14662589752822 3.10775498765719e-12 miRanda -0.694115762893609 1.31745589321569e-15 NA NA NA hsa-miR-590-3p GHR 0.858742926831233 0.000127281269371976 -2.14662589752822 3.10775498765719e-12 mirMAP -0.855556216931225 1.64541595511086e-27 NA NA NA hsa-miR-624-5p GHR 0.220229665946101 0.288248806082627 -2.14662589752822 3.10775498765719e-12 MirTarget -0.663337126426591 4.86668551325216e-12 NA NA NA hsa-miR-651-5p GHR 0.845432672927535 0.000633697547993809 -2.14662589752822 3.10775498765719e-12 MirTarget -0.59827523197628 9.24803321762288e-14 NA NA NA hsa-miR-7-1-3p GHR 0.94398354303717 7.5771319809992e-05 -2.14662589752822 3.10775498765719e-12 MirTarget;mirMAP -0.800115119072627 1.79057651976307e-27 NA NA NA hsa-miR-101-3p GNB1 -0.0683272309939689 0.544163124741916 -0.136532521425138 0.0483922548229369 miRNAWalker2_validate;MirTarget;miRNATAP -0.112538346975865 0.0032596729743644 NA NA NA hsa-miR-320b GNB3 1.21733873788625 7.99882585998487e-07 -0.257700372887913 0.161924861137977 miRanda -0.111297468076472 0.0129379571333133 NA NA NA hsa-miR-326 GNB3 -0.552187708067123 0.039648668341622 -0.257700372887913 0.161924861137977 miRanda -0.100008144097931 0.0172483660923161 NA NA NA hsa-let-7a-3p GNB4 0.283468597868531 0.127007787220086 -0.0613484279829617 0.760832392301006 MirTarget -0.553721359672297 6.53420965558835e-19 NA NA NA hsa-let-7b-3p GNB4 0.377956364821509 0.0061730103051373 -0.0613484279829617 0.760832392301006 MirTarget -0.578782277362568 3.08476615301208e-11 NA NA NA hsa-let-7f-1-3p GNB4 1.09636075438131 3.42037366931931e-10 -0.0613484279829617 0.760832392301006 MirTarget -0.494986180356894 3.84056149584899e-14 NA NA NA hsa-miR-103a-2-5p GNB4 0.668868218338912 0.0220512854713701 -0.0613484279829617 0.760832392301006 MirTarget -0.3152087052461 1.33893468885521e-11 NA NA NA hsa-miR-126-5p GNB4 0.450893496822779 0.0112966412858755 -0.0613484279829617 0.760832392301006 mirMAP -0.379411658294148 2.17967795292512e-08 NA NA NA hsa-miR-155-5p GNB4 0.708423342476697 0.00686702252429413 -0.0613484279829617 0.760832392301006 miRNAWalker2_validate -0.186902336298677 5.40076138224294e-05 NA NA NA hsa-miR-16-2-3p GNB4 0.869267463341732 0.000785361809327569 -0.0613484279829617 0.760832392301006 mirMAP -0.398035649743192 1.33882638197498e-19 NA NA NA hsa-miR-186-5p GNB4 0.35512789129261 0.0196931838168008 -0.0613484279829617 0.760832392301006 MirTarget -0.576841112764555 1.43559985248073e-13 NA NA NA hsa-miR-203a-3p GNB4 0.986535065247669 0.00954714606545506 -0.0613484279829617 0.760832392301006 MirTarget -0.242900741161409 1.36895508579953e-15 NA NA NA hsa-miR-21-3p GNB4 1.87780012411493 8.38052480155167e-17 -0.0613484279829617 0.760832392301006 MirTarget -0.31208955958754 3.77555081592198e-10 NA NA NA hsa-miR-27b-3p GNB4 -0.439806942644624 0.000523870009254693 -0.0613484279829617 0.760832392301006 miRNAWalker2_validate -0.195399682040389 0.0472644756735408 NA NA NA hsa-miR-29a-3p GNB4 -0.235052170104117 0.138527567930958 -0.0613484279829617 0.760832392301006 MirTarget -0.413554824379785 7.24243360270908e-08 NA NA NA hsa-miR-29b-3p GNB4 0.0225365195743876 0.914313337784307 -0.0613484279829617 0.760832392301006 MirTarget -0.41838304962817 1.27917149816363e-13 NA NA NA hsa-miR-338-5p GNB4 -0.420442436641152 0.0583175290447746 -0.0613484279829617 0.760832392301006 MirTarget -0.188606112133062 0.000652040581328445 NA NA NA hsa-miR-33a-3p GNB4 0.21453033253985 0.371591474252951 -0.0613484279829617 0.760832392301006 MirTarget -0.462837803458754 1.8522859795076e-20 NA NA NA hsa-miR-361-5p GNB4 0.538048008019709 1.61165802415302e-07 -0.0613484279829617 0.760832392301006 miRanda;miRNATAP -0.339764083300488 0.00504976425417797 NA NA NA hsa-miR-429 GNB4 1.58250682050303 4.75828087352234e-05 -0.0613484279829617 0.760832392301006 miRanda -0.335858968550378 1.53827773001648e-33 NA NA NA hsa-miR-452-5p GNB4 0.612108901803716 0.0110020550949664 -0.0613484279829617 0.760832392301006 MirTarget -0.128513757365206 0.011691194321799 NA NA NA hsa-miR-501-5p GNB4 1.59306197632625 2.04856600619363e-09 -0.0613484279829617 0.760832392301006 mirMAP -0.309478968460758 8.49162066775934e-12 NA NA NA hsa-miR-582-5p GNB4 0.0720675907490005 0.728284850619144 -0.0613484279829617 0.760832392301006 MirTarget -0.246080047200113 3.0848401464792e-05 NA NA NA hsa-miR-590-3p GNB4 0.858742926831233 0.000127281269371976 -0.0613484279829617 0.760832392301006 MirTarget;miRanda -0.480910480421232 1.43496020642613e-21 NA NA NA hsa-miR-7-1-3p GNB4 0.94398354303717 7.5771319809992e-05 -0.0613484279829617 0.760832392301006 MirTarget -0.45724779129944 2.37955607115607e-22 NA NA NA hsa-miR-877-5p GNB4 1.86786864338556 8.44059777969251e-10 -0.0613484279829617 0.760832392301006 MirTarget -0.258026251549402 3.56535645318547e-10 NA NA NA hsa-miR-93-5p GNB4 1.68243825551104 4.62947431501061e-15 -0.0613484279829617 0.760832392301006 miRNAWalker2_validate -0.330662014292175 3.69637691183196e-10 NA NA NA hsa-miR-96-5p GNB4 1.44821155854693 6.56312590328933e-06 -0.0613484279829617 0.760832392301006 MirTarget -0.361186868435853 1.32613380080833e-22 NA NA NA hsa-miR-128-3p GNB5 0.835320684237761 1.85756253116961e-09 0.0541774185891546 0.702780230234642 miRNAWalker2_validate -0.159576499122589 0.00921723107385594 NA NA NA hsa-miR-130b-3p GNB5 1.29757792612022 1.70655148591568e-06 0.0541774185891546 0.702780230234642 miRNAWalker2_validate -0.180963205142264 2.79111861657215e-09 NA NA NA hsa-miR-148a-3p GNB5 -0.18108394434325 0.495345303586758 0.0541774185891546 0.702780230234642 miRNAWalker2_validate -0.199911475103654 2.56392453610718e-10 NA NA NA hsa-miR-17-5p GNB5 1.57209612312313 5.10453838016207e-11 0.0541774185891546 0.702780230234642 TargetScan -0.215567676707332 1.66120376451916e-10 NA NA NA hsa-miR-26b-5p GNB5 -0.499493687076043 0.0118149973400486 0.0541774185891546 0.702780230234642 miRNAWalker2_validate -0.202210815198017 2.59369483644262e-06 NA NA NA hsa-miR-27a-3p GNB5 0.523219911315699 0.000116410279757859 0.0541774185891546 0.702780230234642 miRNAWalker2_validate -0.24686477610436 0.000103835106017257 NA NA NA hsa-miR-338-3p GNB5 -0.0138760121093551 0.956163634155272 0.0541774185891546 0.702780230234642 miRanda -0.187542869827477 2.32378127632482e-08 NA NA NA hsa-miR-342-3p GNB5 0.235422340773149 0.290471946350276 0.0541774185891546 0.702780230234642 miRanda -0.105775888061644 0.0066241258483894 NA NA NA hsa-miR-425-5p GNB5 0.865319550452351 0.000902803064763851 0.0541774185891546 0.702780230234642 miRNAWalker2_validate -0.197212550883806 6.75706559105245e-10 NA NA NA hsa-miR-429 GNB5 1.58250682050303 4.75828087352234e-05 0.0541774185891546 0.702780230234642 miRanda -0.180849628674123 3.83988450924926e-18 NA NA NA hsa-miR-542-3p GNB5 1.12416854979951 1.02649534578738e-12 0.0541774185891546 0.702780230234642 miRanda -0.154641587262969 0.00346678369456546 NA NA NA hsa-miR-590-3p GNB5 0.858742926831233 0.000127281269371976 0.0541774185891546 0.702780230234642 miRanda -0.208610609883181 2.55140361280975e-08 NA NA NA hsa-miR-320b GNG11 1.21733873788625 7.99882585998487e-07 -0.716639139801645 0.000145494553270365 miRanda -0.18293496612982 6.92083792514978e-05 NA NA NA hsa-miR-330-5p GNG11 0.621676971901542 0.00233177378595631 -0.716639139801645 0.000145494553270365 miRanda -0.263249632758267 2.79838935180592e-06 NA NA NA hsa-miR-107 GNG12 0.85152957824299 1.22369651446858e-11 -0.736928418843964 1.90388724936657e-07 miRanda -0.396645405137824 3.59687602053866e-09 NA NA NA hsa-miR-126-5p GNG12 0.450893496822779 0.0112966412858755 -0.736928418843964 1.90388724936657e-07 mirMAP -0.232893260668307 2.1365757358207e-06 NA NA NA hsa-miR-140-5p GNG12 0.132398579631585 0.457960134430787 -0.736928418843964 1.90388724936657e-07 PITA;miRanda -0.236048117729084 1.66168280750476e-06 NA NA NA hsa-miR-186-5p GNG12 0.35512789129261 0.0196931838168008 -0.736928418843964 1.90388724936657e-07 miRNAWalker2_validate -0.313639841692819 4.62870015601324e-08 NA NA NA hsa-miR-374a-5p GNG12 0.239597788731458 0.0202963000797544 -0.736928418843964 1.90388724936657e-07 mirMAP -0.213324292373718 0.0161963757240886 NA NA NA hsa-miR-374b-5p GNG12 0.00249900187478502 0.985380083859555 -0.736928418843964 1.90388724936657e-07 mirMAP -0.175958437591332 0.00781317554632278 NA NA NA hsa-miR-423-5p GNG12 0.554579912507932 7.65114789083517e-05 -0.736928418843964 1.90388724936657e-07 miRNAWalker2_validate -0.432369912041663 1.10364124987336e-12 NA NA NA hsa-miR-455-5p GNG12 0.644390760445571 0.00262275997170695 -0.736928418843964 1.90388724936657e-07 miRanda -0.198879763032671 8.99187112909151e-07 NA NA NA hsa-miR-542-3p GNG12 1.12416854979951 1.02649534578738e-12 -0.736928418843964 1.90388724936657e-07 miRanda -0.225576536908688 2.58016385787852e-05 NA NA NA hsa-miR-590-3p GNG12 0.858742926831233 0.000127281269371976 -0.736928418843964 1.90388724936657e-07 miRanda;mirMAP -0.27567829952617 1.88443751707894e-13 NA NA NA hsa-miR-590-5p GNG12 0.932604531809045 8.39043954167884e-05 -0.736928418843964 1.90388724936657e-07 PITA -0.23221910142672 8.25691568502196e-11 NA NA NA hsa-miR-96-5p GNG12 1.44821155854693 6.56312590328933e-06 -0.736928418843964 1.90388724936657e-07 TargetScan -0.17356801491228 5.36257209385725e-10 NA NA NA hsa-miR-126-5p GNG2 0.450893496822779 0.0112966412858755 -0.605529121736312 0.000949342195392306 mirMAP -0.141866607497868 0.0261655605508224 NA NA NA hsa-miR-181b-5p GNG2 1.44365471425231 6.03807007335243e-15 -0.605529121736312 0.000949342195392306 miRNATAP -0.145016908177471 0.012705454552534 NA NA NA hsa-miR-21-5p GNG2 2.21515015440792 6.0468197386674e-49 -0.605529121736312 0.000949342195392306 miRNATAP -0.259278564741831 2.95980793440514e-05 NA NA NA hsa-miR-23a-3p GNG2 0.694558223570443 8.99413995422816e-10 -0.605529121736312 0.000949342195392306 miRNATAP -0.362170833507983 0.000234869227011099 NA NA NA hsa-miR-29b-3p GNG2 0.0225365195743876 0.914313337784307 -0.605529121736312 0.000949342195392306 miRNATAP -0.127342955268674 0.0190050031576099 NA NA NA hsa-miR-30d-3p GNG2 0.0608340295673737 0.708110230223927 -0.605529121736312 0.000949342195392306 mirMAP -0.220854984037402 0.00164892039476769 NA NA NA hsa-miR-324-5p GNG2 0.800946351685734 0.00101337664367375 -0.605529121736312 0.000949342195392306 miRanda -0.216109879927427 1.8592900095307e-06 NA NA NA hsa-miR-330-5p GNG2 0.621676971901542 0.00233177378595631 -0.605529121736312 0.000949342195392306 miRanda -0.177033080808234 0.00128136178613961 NA NA NA hsa-miR-335-3p GNG2 2.29463721765513 4.1956113745077e-18 -0.605529121736312 0.000949342195392306 mirMAP -0.267796828879394 2.96397917838353e-12 NA NA NA hsa-miR-429 GNG2 1.58250682050303 4.75828087352234e-05 -0.605529121736312 0.000949342195392306 miRanda;miRNATAP -0.216389821105246 3.81030037652405e-15 NA NA NA hsa-miR-455-5p GNG2 0.644390760445571 0.00262275997170695 -0.605529121736312 0.000949342195392306 miRanda -0.190104799069971 0.000273365319704114 NA NA NA hsa-miR-500a-5p GNG2 1.33126717816499 3.1497328652235e-07 -0.605529121736312 0.000949342195392306 mirMAP -0.193089189261021 3.94261660008293e-06 NA NA NA hsa-miR-576-5p GNG2 0.872721964495849 5.20470410008775e-05 -0.605529121736312 0.000949342195392306 mirMAP -0.231411067478398 6.07926640355746e-06 NA NA NA hsa-miR-577 GNG2 0.615893340074725 0.210494450869356 -0.605529121736312 0.000949342195392306 PITA;miRNATAP -0.113748842833425 3.91908308009637e-06 NA NA NA hsa-miR-590-3p GNG2 0.858742926831233 0.000127281269371976 -0.605529121736312 0.000949342195392306 PITA;miRanda;mirMAP;miRNATAP -0.205018006773586 3.49016821497511e-05 NA NA NA hsa-miR-590-5p GNG2 0.932604531809045 8.39043954167884e-05 -0.605529121736312 0.000949342195392306 miRanda;miRNATAP -0.210635690509387 6.16180792886171e-06 NA NA NA hsa-miR-330-5p GNG3 0.621676971901542 0.00233177378595631 -0.659077763443721 6.8813815619328e-06 miRanda -0.195112878688632 8.89715521155598e-06 NA NA NA hsa-miR-107 GNG4 0.85152957824299 1.22369651446858e-11 -1.60072042333973 0.000794767384488091 miRanda -0.751742699310172 0.00103558397752168 NA NA NA hsa-miR-126-5p GNG4 0.450893496822779 0.0112966412858755 -1.60072042333973 0.000794767384488091 mirMAP -0.331507484365836 0.0466907896716452 NA NA NA hsa-miR-141-3p GNG4 1.76274853293464 9.99331900755725e-07 -1.60072042333973 0.000794767384488091 mirMAP -0.257792836132664 0.00120453549102577 NA NA NA hsa-miR-142-5p GNG4 1.08445947321046 0.000126372881543671 -1.60072042333973 0.000794767384488091 mirMAP -0.348046512425155 0.000676905948121693 NA NA NA hsa-miR-192-3p GNG4 1.78627547479709 3.23498378613139e-06 -1.60072042333973 0.000794767384488091 MirTarget -0.324186087435023 1.28061664080443e-05 NA NA NA hsa-miR-193b-3p GNG4 -0.0325435210716751 0.883410452152887 -1.60072042333973 0.000794767384488091 mirMAP -0.291959857574377 0.0289623388848842 NA NA NA hsa-miR-200a-3p GNG4 2.02394729844446 2.21240501925011e-08 -1.60072042333973 0.000794767384488091 mirMAP -0.315859887550457 5.53226520275043e-05 NA NA NA hsa-miR-200b-3p GNG4 2.06025765178663 3.07718049337497e-10 -1.60072042333973 0.000794767384488091 mirMAP -0.327667595207164 0.000142490431587038 NA NA NA hsa-miR-200c-3p GNG4 1.74925752003763 3.42000026705311e-08 -1.60072042333973 0.000794767384488091 mirMAP -0.27623708532778 0.00218285197835694 NA NA NA hsa-miR-203a-3p GNG4 0.986535065247669 0.00954714606545506 -1.60072042333973 0.000794767384488091 MirTarget -0.295266473302222 0.000107481064632814 NA NA NA hsa-miR-223-5p GNG4 0.814299470198797 0.00250546576879879 -1.60072042333973 0.000794767384488091 mirMAP -0.385660465398353 0.000525636117141265 NA NA NA hsa-miR-23a-3p GNG4 0.694558223570443 8.99413995422816e-10 -1.60072042333973 0.000794767384488091 mirMAP -0.983571162148981 0.000127374250319317 NA NA NA hsa-miR-29a-5p GNG4 1.00715634051951 4.47499137997344e-07 -1.60072042333973 0.000794767384488091 mirMAP -0.756361504951745 1.06184629725117e-07 NA NA NA hsa-miR-324-5p GNG4 0.800946351685734 0.00101337664367375 -1.60072042333973 0.000794767384488091 miRanda -0.282892775387758 0.0186259381342028 NA NA NA hsa-miR-338-3p GNG4 -0.0138760121093551 0.956163634155272 -1.60072042333973 0.000794767384488091 miRanda -0.462229080890175 6.80184104302796e-05 NA NA NA hsa-miR-429 GNG4 1.58250682050303 4.75828087352234e-05 -1.60072042333973 0.000794767384488091 mirMAP -0.279869108455091 0.00019473171566579 NA NA NA hsa-miR-590-3p GNG4 0.858742926831233 0.000127281269371976 -1.60072042333973 0.000794767384488091 miRanda;mirMAP -0.519010338130235 6.05799806725071e-05 NA NA NA hsa-let-7c-5p GNG5 -0.148489254129201 0.548077841857242 -0.055353552706598 0.597245935316213 MirTarget -0.119090765151279 2.8581975220254e-06 NA NA NA hsa-let-7e-5p GNG5 0.227253058773149 0.162290058199053 -0.055353552706598 0.597245935316213 miRNAWalker2_validate;MirTarget;miRNATAP -0.182616220311294 2.84069605661412e-06 NA NA NA hsa-miR-100-5p GNG5 -0.343735526262058 0.133995182819209 -0.055353552706598 0.597245935316213 miRNAWalker2_validate -0.118398672157721 1.65761139749683e-05 NA NA NA hsa-miR-141-3p GNG7 1.76274853293464 9.99331900755725e-07 -2.55105842667086 9.83062399389685e-21 MirTarget;TargetScan;miRNATAP -0.447866825345055 2.60654195504787e-23 NA NA NA hsa-miR-17-3p GNG7 1.37838995268509 5.00444740462873e-13 -2.55105842667086 9.83062399389685e-21 mirMAP -0.877384125133815 2.12420628065995e-26 NA NA NA hsa-miR-181a-2-3p GNG7 0.761758815767271 3.4163207928657e-06 -2.55105842667086 9.83062399389685e-21 mirMAP -0.248630216644494 0.0231733045432827 NA NA NA hsa-miR-182-5p GNG7 1.73826081735237 5.69817940588551e-09 -2.55105842667086 9.83062399389685e-21 mirMAP -0.514473692460829 3.29001200091057e-21 NA NA NA hsa-miR-185-3p GNG7 1.38509197368746 3.93425296894499e-10 -2.55105842667086 9.83062399389685e-21 mirMAP -0.663748819940221 5.51901384611079e-18 NA NA NA hsa-miR-18a-3p GNG7 1.42489363201958 4.87914808744785e-05 -2.55105842667086 9.83062399389685e-21 mirMAP -0.501825397730174 1.56508775668219e-21 NA NA NA hsa-miR-18a-5p GNG7 2.04701000113742 1.30593450319289e-12 -2.55105842667086 9.83062399389685e-21 mirMAP -0.568427533556065 1.83281841195959e-25 NA NA NA hsa-miR-194-3p GNG7 1.91477879150304 2.49480074178753e-07 -2.55105842667086 9.83062399389685e-21 mirMAP -0.313580049736527 3.30088910333563e-11 NA NA NA hsa-miR-1976 GNG7 0.888680419203938 2.16642020734521e-05 -2.55105842667086 9.83062399389685e-21 mirMAP -0.543989868559292 4.02889343102509e-10 NA NA NA hsa-miR-200a-3p GNG7 2.02394729844446 2.21240501925011e-08 -2.55105842667086 9.83062399389685e-21 MirTarget;miRNATAP -0.422442619699771 5.83703169220002e-21 NA NA NA hsa-miR-22-3p GNG7 0.530940324058038 8.6675746679475e-07 -2.55105842667086 9.83062399389685e-21 mirMAP -0.458060352658185 0.00685335901372208 NA NA NA hsa-miR-22-5p GNG7 0.668839167786886 0.00102248931590479 -2.55105842667086 9.83062399389685e-21 mirMAP -0.395366861371595 5.93458862871628e-06 NA NA NA hsa-miR-224-5p GNG7 1.11923763019015 0.000974728485303372 -2.55105842667086 9.83062399389685e-21 mirMAP -0.299103887768441 5.79199512784194e-09 NA NA NA hsa-miR-23a-3p GNG7 0.694558223570443 8.99413995422816e-10 -2.55105842667086 9.83062399389685e-21 mirMAP -1.05260471693994 5.49008914112515e-12 NA NA NA hsa-miR-29b-3p GNG7 0.0225365195743876 0.914313337784307 -2.55105842667086 9.83062399389685e-21 mirMAP -0.259692460324192 0.00272371058689836 NA NA NA hsa-miR-30b-3p GNG7 0.252088263642787 0.216818735503048 -2.55105842667086 9.83062399389685e-21 MirTarget -0.417222163413647 2.17692092535034e-06 NA NA NA hsa-miR-3127-5p GNG7 1.27228064385006 2.39461777008663e-07 -2.55105842667086 9.83062399389685e-21 mirMAP -0.669862045951283 1.9496174936459e-24 NA NA NA hsa-miR-330-5p GNG7 0.621676971901542 0.00233177378595631 -2.55105842667086 9.83062399389685e-21 mirMAP -0.463768438002684 8.29421232962193e-08 NA NA NA hsa-miR-3614-5p GNG7 0.288051497709626 0.339707047011435 -2.55105842667086 9.83062399389685e-21 mirMAP -0.159306320493337 0.016813070404876 NA NA NA hsa-miR-3615 GNG7 0.328938581692365 0.165758557265499 -2.55105842667086 9.83062399389685e-21 mirMAP -0.420909184719298 2.77266595069596e-08 NA NA NA hsa-miR-3913-5p GNG7 1.03696691062365 1.67224447360466e-09 -2.55105842667086 9.83062399389685e-21 mirMAP -0.39971680338825 9.24120474577055e-05 NA NA NA hsa-miR-500a-3p GNG7 1.51438197609577 4.33054210292228e-12 -2.55105842667086 9.83062399389685e-21 mirMAP -0.670026189137326 1.59478741166237e-19 NA NA NA hsa-miR-532-3p GNG7 1.35968112631236 2.41509711096659e-06 -2.55105842667086 9.83062399389685e-21 mirMAP -0.468655152557901 8.40700216686915e-16 NA NA NA hsa-miR-590-3p GNG7 0.858742926831233 0.000127281269371976 -2.55105842667086 9.83062399389685e-21 PITA;miRanda;mirMAP -0.513773586723384 3.05936827939141e-11 NA NA NA hsa-miR-671-5p GNG7 1.6497630797889 2.89172004241043e-12 -2.55105842667086 9.83062399389685e-21 mirMAP -0.592554897365918 8.51367847126291e-18 NA NA NA hsa-miR-92a-3p GNG7 1.06124545165614 6.51550014372282e-08 -2.55105842667086 9.83062399389685e-21 miRNAWalker2_validate -0.881820976322071 3.05774188123267e-27 NA NA NA hsa-miR-940 GNG7 1.3080677738253 2.0056085433599e-05 -2.55105842667086 9.83062399389685e-21 MirTarget -0.404184927232552 1.67867547180507e-12 NA NA NA hsa-miR-96-5p GNG7 1.44821155854693 6.56312590328933e-06 -2.55105842667086 9.83062399389685e-21 mirMAP -0.487149919176422 9.91389450066487e-19 NA NA NA hsa-miR-182-5p GNGT1 1.73826081735237 5.69817940588551e-09 1.1952889570329 0.00616879895280892 MirTarget -0.19697774058896 0.0242218233295035 NA NA NA hsa-miR-219a-1-3p GNGT2 0.974468450651979 2.13180808663812e-05 -0.127002291916065 0.520668017237897 MirTarget -0.153335244752278 0.00428841139687753 NA NA NA hsa-miR-101-3p GSK3B -0.0683272309939689 0.544163124741916 0.265875974150976 0.000454893180511198 miRNATAP -0.108161751914472 0.01087865904704 NA NA NA hsa-miR-26a-5p GSK3B -0.507487084157331 3.23715933371269e-05 0.265875974150976 0.000454893180511198 miRNAWalker2_validate;miRNATAP -0.276398668334029 3.95575891525495e-14 NA NA NA hsa-miR-27b-3p GSK3B -0.439806942644624 0.000523870009254693 0.265875974150976 0.000454893180511198 miRNATAP -0.110459527996732 0.00277108844798185 NA NA NA hsa-miR-28-5p GSK3B -0.22318016376076 0.0194144033008573 0.265875974150976 0.000454893180511198 miRanda;miRNATAP -0.126553177913534 0.0124343156692131 NA NA NA hsa-miR-29a-3p GSK3B -0.235052170104117 0.138527567930958 0.265875974150976 0.000454893180511198 miRNATAP -0.144457662631292 6.53501471959977e-07 NA NA NA hsa-miR-29c-3p GSK3B -1.34143813218298 2.77493790306384e-12 0.265875974150976 0.000454893180511198 miRNATAP -0.155474348899545 3.47249883249066e-12 NA NA NA hsa-miR-30a-3p GSK3B -1.27950866170419 4.33230022379782e-09 0.265875974150976 0.000454893180511198 miRNATAP -0.111611289077542 3.43621966685612e-08 NA NA NA hsa-miR-374a-5p GSK3B 0.239597788731458 0.0202963000797544 0.265875974150976 0.000454893180511198 mirMAP -0.103740072088214 0.0257452070502647 NA NA NA hsa-miR-374b-5p GSK3B 0.00249900187478502 0.985380083859555 0.265875974150976 0.000454893180511198 mirMAP -0.171807057871124 4.56335978277982e-07 NA NA NA hsa-let-7a-3p HGF 0.283468597868531 0.127007787220086 0.300300239635918 0.22287526354436 mirMAP -0.268743622771997 0.000948196211011815 NA NA NA hsa-let-7b-3p HGF 0.377956364821509 0.0061730103051373 0.300300239635918 0.22287526354436 mirMAP -0.261733540924728 0.0179974593427574 NA NA NA hsa-let-7f-1-3p HGF 1.09636075438131 3.42037366931931e-10 0.300300239635918 0.22287526354436 mirMAP -0.306060507769015 0.000245088795871961 NA NA NA hsa-miR-141-3p HGF 1.76274853293464 9.99331900755725e-07 0.300300239635918 0.22287526354436 MirTarget;TargetScan -0.213349561095291 9.73017070619144e-08 NA NA NA hsa-miR-181b-5p HGF 1.44365471425231 6.03807007335243e-15 0.300300239635918 0.22287526354436 mirMAP -0.154817425434699 0.0466006482176149 NA NA NA hsa-miR-200a-3p HGF 2.02394729844446 2.21240501925011e-08 0.300300239635918 0.22287526354436 MirTarget -0.18068176483526 5.88659287877734e-06 NA NA NA hsa-miR-203a-3p HGF 0.986535065247669 0.00954714606545506 0.300300239635918 0.22287526354436 MirTarget -0.200625042472865 1.91364834353406e-07 NA NA NA hsa-miR-26b-5p HGF -0.499493687076043 0.0118149973400486 0.300300239635918 0.22287526354436 MirTarget;miRNATAP -0.243782013221436 0.00128959275741141 NA NA NA hsa-miR-29a-5p HGF 1.00715634051951 4.47499137997344e-07 0.300300239635918 0.22287526354436 mirMAP -0.281141826660062 0.000135488899404617 NA NA NA hsa-miR-30b-5p HGF -0.0106833209203501 0.954966272944722 0.300300239635918 0.22287526354436 mirMAP -0.248256093341597 0.00193204297933459 NA NA NA hsa-miR-30d-5p HGF 0.26829866064717 0.0228954180095085 0.300300239635918 0.22287526354436 mirMAP -0.41099654453337 0.00162924837201285 NA NA NA hsa-miR-30e-5p HGF -0.284839730810255 0.0405852891523165 0.300300239635918 0.22287526354436 mirMAP -0.325716361759286 0.00300072785604573 NA NA NA hsa-miR-335-3p HGF 2.29463721765513 4.1956113745077e-18 0.300300239635918 0.22287526354436 mirMAP -0.136306219189162 0.010470892898055 NA NA NA hsa-miR-33a-3p HGF 0.21453033253985 0.371591474252951 0.300300239635918 0.22287526354436 mirMAP -0.260874933854656 6.33035756000917e-05 NA NA NA hsa-miR-421 HGF 1.26653675546617 2.35180826009926e-08 0.300300239635918 0.22287526354436 miRanda -0.281567000665789 1.35311955330844e-05 NA NA NA hsa-miR-429 HGF 1.58250682050303 4.75828087352234e-05 0.300300239635918 0.22287526354436 miRanda -0.174835934690016 4.55569713608789e-06 NA NA NA hsa-miR-582-5p HGF 0.0720675907490005 0.728284850619144 0.300300239635918 0.22287526354436 PITA -0.199346172135784 0.00632070447036485 NA NA NA hsa-miR-590-3p HGF 0.858742926831233 0.000127281269371976 0.300300239635918 0.22287526354436 miRanda;mirMAP -0.305997571770551 3.31626641072777e-06 NA NA NA hsa-miR-590-5p HGF 0.932604531809045 8.39043954167884e-05 0.300300239635918 0.22287526354436 miRanda -0.320399458063731 2.14908392077837e-07 NA NA NA hsa-miR-651-5p HGF 0.845432672927535 0.000633697547993809 0.300300239635918 0.22287526354436 MirTarget -0.19250704514976 0.00271128465480115 NA NA NA hsa-miR-7-1-3p HGF 0.94398354303717 7.5771319809992e-05 0.300300239635918 0.22287526354436 mirMAP -0.265133949462223 1.76240773532089e-05 NA NA NA hsa-let-7a-5p HRAS 0.298659498236324 0.00963231738125113 0.00221147519554954 0.983992370493816 miRNAWalker2_validate;miRTarBase -0.163839998090049 0.00582922244183095 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-28-3p HSP90AB1 -0.247525872199168 0.0399632425440147 0.795118937135648 2.64301154276922e-12 miRNATAP -0.156296406520455 0.0110187553402687 NA NA NA hsa-miR-1-3p HSP90B1 -2.73171785118192 3.4424534921136e-12 0.42591397534842 4.38034046507526e-05 MirTarget -0.119785514979974 6.04535687464213e-16 NA NA NA hsa-miR-152-3p HSP90B1 -0.111001946024117 0.385698870309139 0.42591397534842 4.38034046507526e-05 MirTarget -0.147705108610192 0.00402731844396416 NA NA NA hsa-miR-129-5p IBSP -1.61803714443871 4.93214379865694e-06 4.57790706132145 1.72830285717164e-16 miRanda -0.44850312062401 8.39930608089558e-06 25344911 Using microarray and BSP Bisulfate Sequencing PCR assays we found that compared with the parent SGC7901/VCR cells expression of miR-129-5p was restored in SGC7901/VCR gastric cancer multi-drug resistant cell line treated by de-methylation reagent 5-AZA-dC gastric cancer hsa-miR-139-5p IBSP -1.41674256628297 4.51005988644234e-14 4.57790706132145 1.72830285717164e-16 miRanda -1.38748816366721 1.99323781308881e-15 NA NA NA hsa-miR-199b-5p IBSP 0.621733599295605 0.000811860893066088 4.57790706132145 1.72830285717164e-16 miRanda -0.410182526387113 0.0352358654354254 NA NA NA hsa-let-7a-3p IGF1 0.283468597868531 0.127007787220086 -0.204400009155359 0.589799367662809 mirMAP -0.632679274189211 2.85197646837506e-07 23974362 Reduced microRNA miRNA let-7a expression and the activation of insulin-like growth factor-1 receptor IGF1R signalling are both involved in prostate cancer and progression; TargetScan predicted three potential target sites T1 T2 and T3 of let-7a in the 3' untranslational region 3' UTR of IGF1R mRNA progression prostate cancer hsa-let-7b-3p IGF1 0.377956364821509 0.0061730103051373 -0.204400009155359 0.589799367662809 mirMAP -0.90679989858257 5.01513185921405e-08 NA NA NA hsa-let-7f-1-3p IGF1 1.09636075438131 3.42037366931931e-10 -0.204400009155359 0.589799367662809 mirMAP -0.894273726533602 5.1059682451022e-13 NA NA NA hsa-miR-103a-2-5p IGF1 0.668868218338912 0.0220512854713701 -0.204400009155359 0.589799367662809 mirMAP -0.483904115786432 5.64699223799067e-08 NA NA NA hsa-miR-130b-3p IGF1 1.29757792612022 1.70655148591568e-06 -0.204400009155359 0.589799367662809 MirTarget -0.660123203950755 6.56666637616651e-17 NA NA NA hsa-miR-142-3p IGF1 1.80134804047727 3.87649742898476e-07 -0.204400009155359 0.589799367662809 miRanda -0.159257517152049 0.0124243304089032 NA NA NA hsa-miR-142-5p IGF1 1.08445947321046 0.000126372881543671 -0.204400009155359 0.589799367662809 MirTarget;PITA;miRNATAP -0.209358641620136 0.00964302621103955 NA NA NA hsa-miR-148a-5p IGF1 0.0805913350009586 0.752183008225566 -0.204400009155359 0.589799367662809 mirMAP -0.334030208498659 0.000220171803251664 NA NA NA hsa-miR-155-5p IGF1 0.708423342476697 0.00686702252429413 -0.204400009155359 0.589799367662809 mirMAP -0.283971155134428 0.00120141206335237 NA NA NA hsa-miR-15b-3p IGF1 0.811179945491507 0.000927520880593552 -0.204400009155359 0.589799367662809 mirMAP -0.796186335965669 9.39510941653056e-20 NA NA NA hsa-miR-16-1-3p IGF1 1.23864765632542 1.24544799589822e-08 -0.204400009155359 0.589799367662809 mirMAP -0.750901815684363 2.48584527302444e-13 NA NA NA hsa-miR-181b-5p IGF1 1.44365471425231 6.03807007335243e-15 -0.204400009155359 0.589799367662809 mirMAP -0.243968258123364 0.0414508585972368 NA NA NA hsa-miR-186-5p IGF1 0.35512789129261 0.0196931838168008 -0.204400009155359 0.589799367662809 mirMAP -0.909549825027277 1.14281873228406e-09 NA NA NA hsa-miR-19a-3p IGF1 1.71062381299889 1.72281025366819e-11 -0.204400009155359 0.589799367662809 MirTarget -0.58494775271473 3.86593331818525e-12 NA NA NA hsa-miR-19b-1-5p IGF1 1.78323584062047 7.55784857614623e-15 -0.204400009155359 0.589799367662809 mirMAP -0.651078769103674 1.56634726413464e-12 NA NA NA hsa-miR-19b-3p IGF1 0.936987029203338 9.28141970787798e-06 -0.204400009155359 0.589799367662809 MirTarget -0.811450424359809 2.88407116220057e-15 NA NA NA hsa-miR-20a-3p IGF1 0.703027135708586 0.022464856696655 -0.204400009155359 0.589799367662809 mirMAP -0.538389743469537 3.94660725576592e-13 NA NA NA hsa-miR-26b-5p IGF1 -0.499493687076043 0.0118149973400486 -0.204400009155359 0.589799367662809 mirMAP -0.571440661962843 6.65700680205677e-07 NA NA NA hsa-miR-27a-3p IGF1 0.523219911315699 0.000116410279757859 -0.204400009155359 0.589799367662809 miRNAWalker2_validate;miRTarBase -1.02549230682261 7.81211264816751e-10 NA NA NA hsa-miR-29a-3p IGF1 -0.235052170104117 0.138527567930958 -0.204400009155359 0.589799367662809 MirTarget -0.543275306147731 0.000214249533646922 NA NA NA hsa-miR-29b-3p IGF1 0.0225365195743876 0.914313337784307 -0.204400009155359 0.589799367662809 MirTarget -0.642335372286232 3.0611232182018e-09 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 1.22580753116505 5.84016077664577e-09 -0.204400009155359 0.589799367662809 MirTarget -0.549073315028496 1.77482174033979e-07 NA NA NA hsa-miR-320a IGF1 0.451741078692272 0.00893327237386749 -0.204400009155359 0.589799367662809 miRNATAP -0.398662299903301 0.00302123680928641 NA NA NA hsa-miR-320b IGF1 1.21733873788625 7.99882585998487e-07 -0.204400009155359 0.589799367662809 miRNATAP -0.490879129348782 5.13842620326382e-08 NA NA NA hsa-miR-33a-3p IGF1 0.21453033253985 0.371591474252951 -0.204400009155359 0.589799367662809 MirTarget -0.617499616766704 3.11357655614444e-10 NA NA NA hsa-miR-3607-3p IGF1 0.479939234340415 0.251616873367277 -0.204400009155359 0.589799367662809 mirMAP -0.210327165946365 0.000199804026573017 NA NA NA hsa-miR-361-5p IGF1 0.538048008019709 1.61165802415302e-07 -0.204400009155359 0.589799367662809 PITA;mirMAP -0.470632146432647 0.0399244401419303 NA NA NA hsa-miR-362-5p IGF1 1.45312548529729 9.37098891085093e-09 -0.204400009155359 0.589799367662809 mirMAP -0.409176656829042 3.12453283569445e-06 NA NA NA hsa-miR-374b-3p IGF1 0.286271228061054 0.169086077672581 -0.204400009155359 0.589799367662809 mirMAP -0.391056396724469 0.000695258587638424 NA NA NA hsa-miR-421 IGF1 1.26653675546617 2.35180826009926e-08 -0.204400009155359 0.589799367662809 PITA -0.600544300719206 8.22991683713901e-10 NA NA NA hsa-miR-454-3p IGF1 0.823770738595667 1.30339728183332e-05 -0.204400009155359 0.589799367662809 MirTarget -0.662316692339977 2.39762464029288e-08 NA NA NA hsa-miR-486-5p IGF1 -1.52128065772506 4.50915908626354e-09 -0.204400009155359 0.589799367662809 PITA;miRNATAP -0.251837116256871 0.00361944009007223 NA NA NA hsa-miR-576-5p IGF1 0.872721964495849 5.20470410008775e-05 -0.204400009155359 0.589799367662809 PITA;mirMAP;miRNATAP -0.766426216611527 4.2350795645226e-14 NA NA NA hsa-miR-577 IGF1 0.615893340074725 0.210494450869356 -0.204400009155359 0.589799367662809 PITA -0.318199226013822 1.4611528659301e-10 NA NA NA hsa-miR-590-3p IGF1 0.858742926831233 0.000127281269371976 -0.204400009155359 0.589799367662809 MirTarget;miRanda;mirMAP;miRNATAP -0.707427497846456 6.61546444668272e-13 NA NA NA hsa-miR-629-5p IGF1 0.812778109967063 7.88203035554668e-05 -0.204400009155359 0.589799367662809 mirMAP -0.5590206519814 3.58823033249313e-07 NA NA NA hsa-miR-940 IGF1 1.3080677738253 2.0056085433599e-05 -0.204400009155359 0.589799367662809 MirTarget;PITA;miRNATAP -0.395723958610628 1.26685741009397e-07 NA NA NA hsa-let-7a-3p IGF1R 0.283468597868531 0.127007787220086 0.116961071763603 0.57112438908184 miRNATAP -0.247474789863321 0.000266920802362134 23974362 Reduced microRNA miRNA let-7a expression and the activation of insulin-like growth factor-1 receptor IGF1R signalling are both involved in prostate cancer and progression; TargetScan predicted three potential target sites T1 T2 and T3 of let-7a in the 3' untranslational region 3' UTR of IGF1R mRNA progression prostate cancer hsa-let-7d-5p IGF1R 0.686819803681087 1.08347860862215e-06 0.116961071763603 0.57112438908184 miRNAWalker2_validate;MirTarget;miRNATAP -0.188187294300314 0.0351191805777623 25287248 Focusing on the let-7d-5p/3p pair the respectively targeted IGF1R and KRAS were shown to be in a reverse relationship with expression of the respective miRNA which was confirmed in transient transfection assays using let-7d mimic or inhibitor; Targeting of KRAS by let-7d was previous reported; targeting of IGF1R by let-7d-5p was confirmed in luciferase assays in this study colon cancer hsa-let-7g-5p IGF1R 0.296128761926282 0.0296823495976068 0.116961071763603 0.57112438908184 MirTarget;miRNATAP -0.270652914492152 0.0039474818529248 NA NA NA hsa-miR-140-5p IGF1R 0.132398579631585 0.457960134430787 0.116961071763603 0.57112438908184 PITA;miRNATAP -0.276642500944028 9.24386215256205e-05 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-141-3p IGF1R 1.76274853293464 9.99331900755725e-07 0.116961071763603 0.57112438908184 TargetScan -0.143116800235417 2.31755572026037e-05 27648145 Insulin-like growth factor 1 receptor IGF1R was overexpressed in AGS cells to investigate miR-141 mechanism gastric cancer hsa-miR-141-5p IGF1R 2.13747696823946 1.73124674554872e-11 0.116961071763603 0.57112438908184 mirMAP -0.129299551872751 0.000639254010113562 27648145 Insulin-like growth factor 1 receptor IGF1R was overexpressed in AGS cells to investigate miR-141 mechanism gastric cancer hsa-miR-148a-5p IGF1R 0.0805913350009586 0.752183008225566 0.116961071763603 0.57112438908184 mirMAP -0.22083292163565 6.22844045828392e-06 NA NA NA hsa-miR-155-5p IGF1R 0.708423342476697 0.00686702252429413 0.116961071763603 0.57112438908184 mirMAP -0.126900539411504 0.0080143150381593 NA NA NA hsa-miR-15a-5p IGF1R 1.07800995489566 4.32072598796529e-10 0.116961071763603 0.57112438908184 miRNATAP -0.241881195675157 0.000633092739375837 NA NA NA hsa-miR-15b-3p IGF1R 0.811179945491507 0.000927520880593552 0.116961071763603 0.57112438908184 mirMAP -0.258404348601088 2.56429479220722e-07 NA NA NA hsa-miR-15b-5p IGF1R 0.637819606405168 0.000580041575431604 0.116961071763603 0.57112438908184 miRNATAP -0.266867812622954 7.26271128735591e-05 NA NA NA hsa-miR-16-1-3p IGF1R 1.23864765632542 1.24544799589822e-08 0.116961071763603 0.57112438908184 mirMAP -0.1603983672133 0.00590403598378345 NA NA NA hsa-miR-16-5p IGF1R 0.468459442059375 0.02635007201346 0.116961071763603 0.57112438908184 miRNATAP -0.294886587581129 5.30338289297577e-07 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-182-5p IGF1R 1.73826081735237 5.69817940588551e-09 0.116961071763603 0.57112438908184 mirMAP;miRNATAP -0.122000615718107 0.00283752174494098 27468875 MicroRNA 182 suppresses clear cell renal cell carcinoma migration and invasion by targeting IGF1R; Luciferase reporter assay qRT-PCR and Western blotting were used to determine whether insulin-like growth factor 1 receptor IGF1R was a target of miR-182; Further small interfering RNA siRNA against IGF1R was co-transfected with miR-182 inhibitor into cells and then the effects on migration and invasion were assessed; Luciferase reporter assay confirmed that IGF1R was a target gene of miR-182 and IGF1R was negatively regulated by miR-182; MiR-182 functions as an anti-oncogene in ccRCC and miR-182-mediated inhibition of cell migration and invasion might be through directly targeting IGF1R cell migration kidney renal cell cancer hsa-miR-183-5p IGF1R 2.08412478942637 1.08931431254487e-10 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.108412615681544 0.00383685739243794 NA NA NA hsa-miR-186-5p IGF1R 0.35512789129261 0.0196931838168008 0.116961071763603 0.57112438908184 mirMAP -0.258522752720877 0.0019366763106871 NA NA NA hsa-miR-192-5p IGF1R 2.0867723747501 3.57854249239079e-08 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.147175389757737 3.89731047961255e-06 NA NA NA hsa-miR-194-3p IGF1R 1.91477879150304 2.49480074178753e-07 0.116961071763603 0.57112438908184 MirTarget -0.124377157341824 0.00024588369374847 NA NA NA hsa-miR-194-5p IGF1R 2.24386881692218 9.35116329002209e-11 0.116961071763603 0.57112438908184 miRNAWalker2_validate;miRTarBase;miRNATAP -0.139203332288475 5.93692812368786e-05 NA NA NA hsa-miR-195-5p IGF1R -1.07154705036962 4.16544134775761e-08 0.116961071763603 0.57112438908184 miRNATAP -0.137649221915613 0.02965949583708 NA NA NA hsa-miR-197-3p IGF1R 0.540951726189935 0.00440139185360704 0.116961071763603 0.57112438908184 mirMAP -0.146270257652769 0.0278752991615709 NA NA NA hsa-miR-19a-3p IGF1R 1.71062381299889 1.72281025366819e-11 0.116961071763603 0.57112438908184 mirMAP -0.124661811086297 0.00889274990718644 NA NA NA hsa-miR-20a-3p IGF1R 0.703027135708586 0.022464856696655 0.116961071763603 0.57112438908184 mirMAP -0.11558478122019 0.00603995795587773 NA NA NA hsa-miR-215-5p IGF1R 1.10296552366805 0.0225256935718223 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.125566597748775 8.1030935945269e-07 NA NA NA hsa-miR-22-5p IGF1R 0.668839167786886 0.00102248931590479 0.116961071763603 0.57112438908184 miRNATAP -0.211451493517287 0.000570215052633364 NA NA NA hsa-miR-26b-3p IGF1R 0.312629571566403 0.245454206213408 0.116961071763603 0.57112438908184 miRNATAP -0.144309873387508 0.00201483827208465 NA NA NA hsa-miR-29a-3p IGF1R -0.235052170104117 0.138527567930958 0.116961071763603 0.57112438908184 mirMAP -0.245306889317265 0.00221628572784376 NA NA NA hsa-miR-29a-5p IGF1R 1.00715634051951 4.47499137997344e-07 0.116961071763603 0.57112438908184 miRNATAP -0.181969540474862 0.00333429724032899 NA NA NA hsa-miR-29b-2-5p IGF1R -0.39718520927539 0.0233851474877787 0.116961071763603 0.57112438908184 mirMAP -0.172561866073503 0.017189952509538 NA NA NA hsa-miR-29b-3p IGF1R 0.0225365195743876 0.914313337784307 0.116961071763603 0.57112438908184 mirMAP -0.23987591361808 6.41824530563694e-05 NA NA NA hsa-miR-29c-3p IGF1R -1.34143813218298 2.77493790306384e-12 0.116961071763603 0.57112438908184 mirMAP -0.220885441878803 0.000445071703384631 NA NA NA hsa-miR-30b-5p IGF1R -0.0106833209203501 0.954966272944722 0.116961071763603 0.57112438908184 mirMAP -0.241157388260387 0.000305356265294653 NA NA NA hsa-miR-30e-5p IGF1R -0.284839730810255 0.0405852891523165 0.116961071763603 0.57112438908184 mirMAP -0.376259921286222 3.65026261618468e-05 NA NA NA hsa-miR-320b IGF1R 1.21733873788625 7.99882585998487e-07 0.116961071763603 0.57112438908184 PITA;mirMAP;miRNATAP -0.129051555360876 0.0100109730432147 NA NA NA hsa-miR-330-3p IGF1R 0.391166748754241 0.0581284813543685 0.116961071763603 0.57112438908184 MirTarget;PITA;miRNATAP -0.130032795980184 0.0406021161421894 NA NA NA hsa-miR-331-5p IGF1R 0.703863188605486 4.25406757208802e-05 0.116961071763603 0.57112438908184 PITA -0.160951663442437 0.0283074243056235 NA NA NA hsa-miR-335-5p IGF1R 0.576542642348884 0.01886326850059 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.106620818963744 0.0387028152354209 NA NA NA hsa-miR-339-5p IGF1R 0.51232205151031 0.0560469213103598 0.116961071763603 0.57112438908184 miRanda -0.126662397259375 0.00693431529814802 NA NA NA hsa-miR-33a-3p IGF1R 0.21453033253985 0.371591474252951 0.116961071763603 0.57112438908184 miRNATAP -0.265817454948283 9.21098516926611e-07 NA NA NA hsa-miR-34a-5p IGF1R 0.691825068787607 0.00069818668499891 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.254563093978196 2.89865633558959e-05 NA NA NA hsa-miR-3613-5p IGF1R 1.03938524872813 2.63575941507995e-05 0.116961071763603 0.57112438908184 mirMAP;miRNATAP -0.217284542760047 1.28523748872099e-05 NA NA NA hsa-miR-362-3p IGF1R 0.994614346444282 4.39793878186399e-05 0.116961071763603 0.57112438908184 PITA -0.186825854196549 0.000382088502977399 NA NA NA hsa-miR-3677-3p IGF1R 1.20148333109079 2.61549985227394e-05 0.116961071763603 0.57112438908184 MirTarget -0.198451651763507 5.39619172914117e-06 NA NA NA hsa-miR-374a-5p IGF1R 0.239597788731458 0.0202963000797544 0.116961071763603 0.57112438908184 mirMAP -0.249736121423622 0.0487566154605167 NA NA NA hsa-miR-374b-5p IGF1R 0.00249900187478502 0.985380083859555 0.116961071763603 0.57112438908184 mirMAP -0.202785741882532 0.0319466713213973 NA NA NA hsa-miR-375 IGF1R -0.348733074320394 0.47719066431766 0.116961071763603 0.57112438908184 miRNATAP -0.106616085041966 2.60461910977651e-05 27129171;24571711;21813472 Together these results show that AE modulates cancer cells and the tumor microenvironment via activation of miR-375 and by targeting IGF1R and SNAIL1 in OC cells;Epigenetic silencing of miR 375 induces trastuzumab resistance in HER2 positive breast cancer by targeting IGF1R; miR-375 which was downregulated and predicted to target IGF1R in trastuzumab-resistant HER2-positive breast cancer cells could indeed inhibit the cellular luciferase activity in a reporter construct containing the 3'-UTR of IGF1R; A reverse correlation between the levels of miR-375 and IGF1R was validated in clinical breast cancers; Epigenetic silencing of miR-375 causes the upregulation of IGF1R which at least partially underlies trastuzumab resistance of breast cancer cells;Real-time quantitative PCR was applied to detectthe expression of miR-375 in ESCC samples and its correlation with insulin-like growth factor 1 receptor IGF1R; Further study showed that miR-375 could interact with the 3'-untranslated region of IGF1R and downregulate its expression; In clinical specimens the expression of IGF1R was also negatively correlated with miR-375 expression p=0.008; This study demonstrates that miR-375 has a strong tumour-suppressive effect through inhibiting the expression of IGF1R ;drug resistance; ovarian cancer;breast cancer;esophageal cancer hsa-miR-378a-3p IGF1R -0.640299638006855 0.000817347521910841 0.116961071763603 0.57112438908184 miRTarBase;MirTarget;miRNATAP -0.188637241629666 0.00404569733836923 24119742;25427715;24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues ;; liver cancer;sarcoma;colorectal cancer hsa-miR-378a-5p IGF1R -0.684033095877066 0.000471076679969606 0.116961071763603 0.57112438908184 mirMAP -0.2601738727367 4.26138457851162e-05 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-378c IGF1R -0.575296185389261 0.00108559337111042 0.116961071763603 0.57112438908184 MirTarget;miRNATAP -0.192484239948071 0.00715568337546646 NA NA NA hsa-miR-424-5p IGF1R 0.956135912596328 0.00035164943928494 0.116961071763603 0.57112438908184 miRNATAP -0.183104188337077 7.53079123119793e-05 NA NA NA hsa-miR-429 IGF1R 1.58250682050303 4.75828087352234e-05 0.116961071763603 0.57112438908184 miRanda;miRNATAP -0.149290490968091 2.84616336986197e-06 NA NA NA hsa-miR-452-5p IGF1R 0.612108901803716 0.0110020550949664 0.116961071763603 0.57112438908184 mirMAP -0.144930225932983 0.00547033214776613 NA NA NA hsa-miR-455-5p IGF1R 0.644390760445571 0.00262275997170695 0.116961071763603 0.57112438908184 miRNATAP -0.192600109108588 0.000983407318204755 NA NA NA hsa-miR-484 IGF1R 0.401753773460753 0.0490851523101605 0.116961071763603 0.57112438908184 miRNAWalker2_validate -0.215983323077241 0.000453819008736881 NA NA NA hsa-miR-497-5p IGF1R -0.486115215577409 0.00973897247186318 0.116961071763603 0.57112438908184 miRNAWalker2_validate;miRTarBase;miRNATAP -0.163377392004303 0.0150875729672908 NA NA NA hsa-miR-500a-3p IGF1R 1.51438197609577 4.33054210292228e-12 0.116961071763603 0.57112438908184 mirMAP -0.17932399559197 0.00116132289679447 NA NA NA hsa-miR-502-5p IGF1R 0.873538712251823 0.0012275719769761 0.116961071763603 0.57112438908184 PITA;miRNATAP -0.192607908444164 0.000337855431428033 NA NA NA hsa-miR-532-5p IGF1R 1.45407925817457 1.88450871132345e-14 0.116961071763603 0.57112438908184 miRNATAP -0.192902999163704 0.00227488755987935 NA NA NA hsa-miR-542-3p IGF1R 1.12416854979951 1.02649534578738e-12 0.116961071763603 0.57112438908184 mirMAP -0.156133311605568 0.0437529966662499 NA NA NA hsa-miR-625-5p IGF1R 0.748754910408313 0.00783938428700196 0.116961071763603 0.57112438908184 MirTarget -0.135215125267422 0.00273031087579644 NA NA NA hsa-miR-629-3p IGF1R 0.597278340934362 0.0508108703940013 0.116961071763603 0.57112438908184 mirMAP -0.105582919496177 0.0166148944138749 NA NA NA hsa-miR-664a-5p IGF1R -0.185366485838763 0.391076957229399 0.116961071763603 0.57112438908184 mirMAP -0.121805071693871 0.0434959899832935 NA NA NA hsa-miR-671-5p IGF1R 1.6497630797889 2.89172004241043e-12 0.116961071763603 0.57112438908184 mirMAP -0.170748569141947 0.000806066156306104 NA NA NA hsa-miR-7-1-3p IGF1R 0.94398354303717 7.5771319809992e-05 0.116961071763603 0.57112438908184 mirMAP -0.141949642628416 0.00656657307232053 NA NA NA hsa-miR-7-5p IGF1R 1.20202447072014 0.000123775346787165 0.116961071763603 0.57112438908184 miRNAWalker2_validate;mirMAP -0.116867954939533 0.00587801665415595 22614005 Moreover the insulin-like growth factor-1 receptor IGF1R oncogene which is often mutated or amplified in human cancers and functions as an important regulator of cell growth and tumor invasion was identified as a direct target of miR-7; Silencing of IGF1R using small interefering RNA siRNA recapitulated the anti-metastatic function of miR-7 whereas restoring the IGF1R expression attenuated the function of miR-7 in GC cells; Finally analyses of miR-7 and IGF1R levels in human primary GC with matched lymph node metastasis tissue arrays revealed that miR-7 is inversely correlated with IGF1R expression metastasis gastric cancer hsa-miR-940 IGF1R 1.3080677738253 2.0056085433599e-05 0.116961071763603 0.57112438908184 mirMAP -0.11565731205129 0.00535204505031191 NA NA NA hsa-miR-96-5p IGF1R 1.44821155854693 6.56312590328933e-06 0.116961071763603 0.57112438908184 TargetScan;miRNATAP -0.123612797642628 0.00255706572383707 NA NA NA hsa-miR-98-5p IGF1R 0.72508924193932 6.07191196761022e-10 0.116961071763603 0.57112438908184 MirTarget -0.554478779609063 1.15422142217762e-07 NA NA NA hsa-miR-130b-3p IGF2 1.29757792612022 1.70655148591568e-06 0.847971814336397 0.0384171333184512 mirMAP -0.266057379478082 0.00335243234887564 NA NA NA hsa-miR-141-3p IGF2 1.76274853293464 9.99331900755725e-07 0.847971814336397 0.0384171333184512 MirTarget;TargetScan -0.270767801935397 6.08055499461625e-05 NA NA NA hsa-miR-148a-3p IGF2 -0.18108394434325 0.495345303586758 0.847971814336397 0.0384171333184512 mirMAP -0.394303728639774 2.61633483681797e-05 NA NA NA hsa-miR-148b-3p IGF2 0.719517328390822 3.51245964668412e-05 0.847971814336397 0.0384171333184512 mirMAP -0.337373399592068 0.0190092573849574 NA NA NA hsa-miR-150-5p IGF2 0.391701745753361 0.166399987744223 0.847971814336397 0.0384171333184512 miRNAWalker2_validate -0.246181752306418 0.00547927702135712 NA NA NA hsa-miR-192-3p IGF2 1.78627547479709 3.23498378613139e-06 0.847971814336397 0.0384171333184512 miRNATAP -0.194334311382482 0.00237000445898338 NA NA NA hsa-miR-192-5p IGF2 2.0867723747501 3.57854249239079e-08 0.847971814336397 0.0384171333184512 mirMAP -0.211833680052481 0.000963243771178195 NA NA NA hsa-miR-19a-3p IGF2 1.71062381299889 1.72281025366819e-11 0.847971814336397 0.0384171333184512 mirMAP -0.206573623090281 0.0299752903054474 NA NA NA hsa-miR-19b-3p IGF2 0.936987029203338 9.28141970787798e-06 0.847971814336397 0.0384171333184512 mirMAP -0.335679476652656 0.00418532951306867 NA NA NA hsa-miR-200a-3p IGF2 2.02394729844446 2.21240501925011e-08 0.847971814336397 0.0384171333184512 MirTarget -0.240494037581915 0.000331938332830703 NA NA NA hsa-miR-210-3p IGF2 1.43213884766567 0.00254213404458026 0.847971814336397 0.0384171333184512 MirTarget -0.115332111128938 0.0279564912815311 NA NA NA hsa-miR-23a-5p IGF2 0.167405253373335 0.600759660436359 0.847971814336397 0.0384171333184512 MirTarget -0.318029306739137 0.000156338644054825 NA NA NA hsa-miR-342-5p IGF2 0.894527325844054 0.000286684345522657 0.847971814336397 0.0384171333184512 MirTarget;mirMAP;miRNATAP -0.370070841059868 0.000223874199024517 NA NA NA hsa-miR-34a-5p IGF2 0.691825068787607 0.00069818668499891 0.847971814336397 0.0384171333184512 mirMAP -0.550526216707818 5.36032278121725e-06 NA NA NA hsa-miR-361-3p IGF2 0.485361250955594 0.00074097948047418 0.847971814336397 0.0384171333184512 mirMAP -0.527552454567724 0.00264525235199702 NA NA NA hsa-miR-362-3p IGF2 0.994614346444282 4.39793878186399e-05 0.847971814336397 0.0384171333184512 miRanda -0.343544137936255 0.00107203575739745 NA NA NA hsa-miR-454-3p IGF2 0.823770738595667 1.30339728183332e-05 0.847971814336397 0.0384171333184512 mirMAP -0.457318325185693 0.000482203628722367 NA NA NA hsa-miR-484 IGF2 0.401753773460753 0.0490851523101605 0.847971814336397 0.0384171333184512 miRNATAP -0.331857805805786 0.00714420705263544 NA NA NA hsa-miR-744-3p IGF2 0.704156170726514 0.016011687012928 0.847971814336397 0.0384171333184512 mirMAP -0.218704327480892 0.0118694820961997 NA NA NA hsa-miR-744-5p IGF2 0.734924181943417 2.06706878377701e-05 0.847971814336397 0.0384171333184512 MirTarget -0.296277495158395 0.0410191292444276 NA NA NA hsa-miR-3065-3p IL2RA -0.00685158653722073 0.979081293235379 1.08058445137912 5.53160091101668e-06 MirTarget -0.120463236243038 0.034254550577995 NA NA NA hsa-miR-429 IL4R 1.58250682050303 4.75828087352234e-05 -0.28377948407667 0.0146659914501332 miRNATAP -0.10310689126845 6.82733583873093e-09 NA NA NA hsa-miR-338-5p IL6 -0.420442436641152 0.0583175290447746 -0.40329665856168 0.305687483294743 MirTarget;PITA -0.217140515054178 0.0465758252785243 NA NA NA hsa-miR-429 IL6 1.58250682050303 4.75828087352234e-05 -0.40329665856168 0.305687483294743 miRanda -0.240310159676854 8.8300156337791e-05 NA NA NA hsa-let-7a-5p IL6R 0.298659498236324 0.00963231738125113 -1.21161276372315 1.03367113948549e-09 TargetScan;miRNATAP -0.298329705583042 0.00735895230157706 NA NA NA hsa-let-7b-5p IL6R 0.16896311055967 0.160596228583843 -1.21161276372315 1.03367113948549e-09 miRNATAP -0.294261019632435 0.00585560789307846 NA NA NA hsa-miR-103a-2-5p IL6R 0.668868218338912 0.0220512854713701 -1.21161276372315 1.03367113948549e-09 mirMAP -0.13732413072244 0.00528542770763417 NA NA NA hsa-miR-106b-5p IL6R 1.08518388423396 4.82746923373852e-09 -1.21161276372315 1.03367113948549e-09 mirMAP -0.343171782242603 1.16214061007825e-07 NA NA NA hsa-miR-130b-3p IL6R 1.29757792612022 1.70655148591568e-06 -1.21161276372315 1.03367113948549e-09 mirMAP -0.20908662957987 2.91316325145685e-06 NA NA NA hsa-miR-135b-5p IL6R 2.80066701698235 2.12546333413447e-11 -1.21161276372315 1.03367113948549e-09 mirMAP -0.138010681660297 3.35550660139864e-06 NA NA NA hsa-miR-141-3p IL6R 1.76274853293464 9.99331900755725e-07 -1.21161276372315 1.03367113948549e-09 MirTarget -0.150699481142674 7.18115377712653e-06 NA NA NA hsa-miR-141-5p IL6R 2.13747696823946 1.73124674554872e-11 -1.21161276372315 1.03367113948549e-09 MirTarget -0.154108356158782 3.94728696393256e-05 NA NA NA hsa-miR-146b-5p IL6R 2.23105707690238 3.83997814011313e-23 -1.21161276372315 1.03367113948549e-09 miRanda -0.119662585345475 0.0194175962393968 NA NA NA hsa-miR-17-5p IL6R 1.57209612312313 5.10453838016207e-11 -1.21161276372315 1.03367113948549e-09 mirMAP -0.286591306317455 5.84624495585699e-09 NA NA NA hsa-miR-182-5p IL6R 1.73826081735237 5.69817940588551e-09 -1.21161276372315 1.03367113948549e-09 mirMAP -0.284623551098185 2.99478274114974e-13 NA NA NA hsa-miR-197-3p IL6R 0.540951726189935 0.00440139185360704 -1.21161276372315 1.03367113948549e-09 MirTarget -0.188979074902115 0.00417321864926797 NA NA NA hsa-miR-200a-3p IL6R 2.02394729844446 2.21240501925011e-08 -1.21161276372315 1.03367113948549e-09 MirTarget -0.180898698182907 3.84982463404944e-08 NA NA NA hsa-miR-20a-5p IL6R 1.57190995476158 8.72275528729458e-12 -1.21161276372315 1.03367113948549e-09 mirMAP -0.285928926805436 2.29986490591833e-08 NA NA NA hsa-miR-21-5p IL6R 2.21515015440792 6.0468197386674e-49 -1.21161276372315 1.03367113948549e-09 MirTarget;miRNATAP -0.425484681993678 2.96975015882595e-10 NA NA NA hsa-miR-23a-3p IL6R 0.694558223570443 8.99413995422816e-10 -1.21161276372315 1.03367113948549e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.382820789796031 0.000472235431764954 NA NA NA hsa-miR-29a-5p IL6R 1.00715634051951 4.47499137997344e-07 -1.21161276372315 1.03367113948549e-09 mirMAP -0.206563580116611 0.000787281203652336 NA NA NA hsa-miR-29b-1-5p IL6R 1.27585983480192 1.70509960024426e-05 -1.21161276372315 1.03367113948549e-09 mirMAP -0.114580763675554 0.00613224239482457 NA NA NA hsa-miR-301a-3p IL6R 1.22580753116505 5.84016077664577e-09 -1.21161276372315 1.03367113948549e-09 mirMAP -0.182626556493627 0.00159558518888483 NA NA NA hsa-miR-30d-5p IL6R 0.26829866064717 0.0228954180095085 -1.21161276372315 1.03367113948549e-09 mirMAP -0.296728395876266 0.00641937160662925 NA NA NA hsa-miR-320b IL6R 1.21733873788625 7.99882585998487e-07 -1.21161276372315 1.03367113948549e-09 miRanda;miRNATAP -0.174571007106641 0.000430245338602424 NA NA NA hsa-miR-330-3p IL6R 0.391166748754241 0.0581284813543685 -1.21161276372315 1.03367113948549e-09 miRNATAP -0.166669735406138 0.00817173640768771 NA NA NA hsa-miR-331-3p IL6R 0.818192524829557 0.000359485856225569 -1.21161276372315 1.03367113948549e-09 MirTarget -0.119144802027002 0.0284213828387879 NA NA NA hsa-miR-335-5p IL6R 0.576542642348884 0.01886326850059 -1.21161276372315 1.03367113948549e-09 mirMAP -0.140981850451836 0.00584773655356026 NA NA NA hsa-miR-421 IL6R 1.26653675546617 2.35180826009926e-08 -1.21161276372315 1.03367113948549e-09 mirMAP -0.249149122452852 3.55844392035447e-06 NA NA NA hsa-miR-501-5p IL6R 1.59306197632625 2.04856600619363e-09 -1.21161276372315 1.03367113948549e-09 miRNATAP -0.19562897619233 3.81615229142199e-05 NA NA NA hsa-miR-576-5p IL6R 0.872721964495849 5.20470410008775e-05 -1.21161276372315 1.03367113948549e-09 mirMAP -0.184665378062871 0.00128572094362008 NA NA NA hsa-miR-590-3p IL6R 0.858742926831233 0.000127281269371976 -1.21161276372315 1.03367113948549e-09 mirMAP -0.154707465169443 0.00531843811380544 NA NA NA hsa-miR-590-5p IL6R 0.932604531809045 8.39043954167884e-05 -1.21161276372315 1.03367113948549e-09 MirTarget;miRNATAP -0.122595460544606 0.0195122043263934 NA NA NA hsa-miR-708-3p IL6R 1.89970412556434 1.57072858438086e-13 -1.21161276372315 1.03367113948549e-09 mirMAP -0.111982124014698 0.0159889662763947 NA NA NA hsa-miR-93-5p IL6R 1.68243825551104 4.62947431501061e-15 -1.21161276372315 1.03367113948549e-09 mirMAP -0.351498568240955 5.56054012351993e-11 NA NA NA hsa-miR-942-5p IL6R 0.971074085161366 9.47503417656145e-05 -1.21161276372315 1.03367113948549e-09 MirTarget -0.176302634963165 0.000375086743725411 NA NA NA hsa-miR-98-5p IL6R 0.72508924193932 6.07191196761022e-10 -1.21161276372315 1.03367113948549e-09 miRNAWalker2_validate -0.504853059570403 1.37114577188711e-06 NA NA NA hsa-miR-125a-3p IL7 0.0862037949225951 0.688453004025032 -0.0340230528789749 0.868358977072182 miRanda -0.159367382718127 0.0072230099850523 NA NA NA hsa-miR-335-3p IL7R 2.29463721765513 4.1956113745077e-18 -0.0580891903764487 0.822485344953704 mirMAP -0.168485636327691 0.00251189798098582 NA NA NA hsa-let-7a-3p INSR 0.283468597868531 0.127007787220086 0.318597619732127 0.00888759738704957 mirMAP -0.124209669806432 0.00205429421424021 NA NA NA hsa-miR-15b-3p INSR 0.811179945491507 0.000927520880593552 0.318597619732127 0.00888759738704957 mirMAP -0.107638424617865 0.000340513626145571 NA NA NA hsa-miR-15b-5p INSR 0.637819606405168 0.000580041575431604 0.318597619732127 0.00888759738704957 miRNATAP -0.133079938619787 0.000867661882945889 NA NA NA hsa-miR-16-5p INSR 0.468459442059375 0.02635007201346 0.318597619732127 0.00888759738704957 miRNATAP -0.132412543732975 0.000164501860539401 NA NA NA hsa-miR-27a-3p INSR 0.523219911315699 0.000116410279757859 0.318597619732127 0.00888759738704957 miRNATAP -0.165140397548813 0.00274607414747571 NA NA NA hsa-miR-27b-3p INSR -0.439806942644624 0.000523870009254693 0.318597619732127 0.00888759738704957 miRNATAP -0.188276970992336 0.0015153390830919 NA NA NA hsa-miR-30e-3p INSR -0.444998679251398 0.000501880465265124 0.318597619732127 0.00888759738704957 mirMAP -0.259779242347318 8.31872087624852e-06 NA NA NA hsa-miR-374a-3p INSR 0.0703956336838676 0.602396227448772 0.318597619732127 0.00888759738704957 mirMAP -0.204462731718196 0.000259786536023167 NA NA NA hsa-miR-495-3p INSR -0.024887553302567 0.897251687801771 0.318597619732127 0.00888759738704957 mirMAP -0.128585419888116 0.000929652522729233 NA NA NA hsa-miR-590-3p INSR 0.858742926831233 0.000127281269371976 0.318597619732127 0.00888759738704957 PITA;miRanda;mirMAP;miRNATAP -0.10184078371458 0.00199297723295857 NA NA NA hsa-miR-126-3p IRS1 0.534607988028606 0.0280888039710076 -0.0263168100229603 0.888545775357123 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12348270102601 0.0085878796812917 24312276;23981989;26893720 Down regulation of miR 126 is associated with colorectal cancer cells proliferation migration and invasion by targeting IRS 1 via the AKT and ERK1/2 signaling pathways; In this study we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 IRS-1 and its possible signaling pathway by miR-126; The 3'-untranslated region 3'-UTR of IRS-1 regulated by miR-126 was analyzed by using a dual-luciferase reporter assay; We found that IRS-1 is the functional downstream target of miR-126 by directly targeting the 3'-UTR of IRS-1; Endogenous miR-126 and exogenous miR-126 mimic inhibited IRS-1 expression; Furthermore gain-of-function or loss-of-function studies showed that over-expression of miR-126 down-regulated IRS-1 suppressed AKT and ERK1/2 activation CRC cells proliferation migration invasion and caused cell cycle arrest but had no effect on cell apoptosis; Knockdown of miR-126 promoted these processes in HCT-116 cells and promoted AKT and ERK1/2 activation by up-regulating the expression of the IRS-1 protein; MiR-126 may play roles in regulation of the biological behavior of CRC cells at least in part by targeting IRS-1 via AKT and ERK1/2 signaling pathways;It has been shown that IRS1 SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer;Molecular mechanism investigation established that insulin receptor substrate 1 IRS1 functioned as a direct miR-126 target and its expression was negatively regulated by miR-126 at a post-transcriptional level in the SKOV3 cells; Additionally the overexpression of IRS1 reversed the inhibitory effect of miR-126 overexpression on SKOV3 cell migration and invasion; In conclusion the current study demonstrated that miR-126 inhibited EC cell migration and invasion at least partially through the direct targeting of IRS1 suggesting that miR-126 may aid the treatment of EC metastasis ;;cell migration;metastasis colorectal cancer;colon cancer;endometrial cancer hsa-miR-128-3p IRS1 0.835320684237761 1.85756253116961e-09 -0.0263168100229603 0.888545775357123 MirTarget -0.294438725177709 0.000262056364942211 26352220 In addition insulin receptor substrate 1 IRS1 a key mediator in oncogenic insulin-like growth factor IGF signaling was confirmed as a direct target of miR-128 by a luciferase reporter assay; Western blot analysis indicated that the overexpression of miR-128 significantly downregulated IRS1 expression and its downstream Akt signaling in CRC cells; Moreover miR-128 was negatively associated with IRS1 in CRC tissues compared to adjacent non-tumor tissues; Taken together these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1 metastasis colorectal cancer hsa-miR-142-5p IRS1 1.08445947321046 0.000126372881543671 -0.0263168100229603 0.888545775357123 MirTarget;PITA -0.130641867635428 0.00104019698899392 NA NA NA hsa-miR-148a-3p IRS1 -0.18108394434325 0.495345303586758 -0.0263168100229603 0.888545775357123 miRNAWalker2_validate;miRTarBase -0.215079476058868 4.01047545954139e-07 NA NA NA hsa-miR-16-1-3p IRS1 1.23864765632542 1.24544799589822e-08 -0.0263168100229603 0.888545775357123 MirTarget -0.24258248388985 3.44355796048782e-06 NA NA NA hsa-miR-17-3p IRS1 1.37838995268509 5.00444740462873e-13 -0.0263168100229603 0.888545775357123 MirTarget -0.230697785032874 5.38148670882177e-05 NA NA NA hsa-miR-183-5p IRS1 2.08412478942637 1.08931431254487e-10 -0.0263168100229603 0.888545775357123 MirTarget;miRNATAP -0.189726830921609 1.23209031057426e-08 NA NA NA hsa-miR-200b-3p IRS1 2.06025765178663 3.07718049337497e-10 -0.0263168100229603 0.888545775357123 TargetScan -0.178970489896676 5.95671901451481e-08 26314828 Taken together our results suggest that miR-200 may activate AKT in lung adenocarcinoma cells through a FOG2-independent mechanism involving IRS-1 lung cancer hsa-miR-200c-3p IRS1 1.74925752003763 3.42000026705311e-08 -0.0263168100229603 0.888545775357123 miRNATAP -0.1883013203419 4.28766703128298e-08 NA NA NA hsa-miR-203a-3p IRS1 0.986535065247669 0.00954714606545506 -0.0263168100229603 0.888545775357123 MirTarget -0.167202015009606 9.59479036868634e-09 NA NA NA hsa-miR-27a-3p IRS1 0.523219911315699 0.000116410279757859 -0.0263168100229603 0.888545775357123 MirTarget;miRNATAP -0.212785027186605 0.0122387715041117 NA NA NA hsa-miR-30b-5p IRS1 -0.0106833209203501 0.954966272944722 -0.0263168100229603 0.888545775357123 MirTarget -0.141407806209904 0.0207318010530464 NA NA NA hsa-miR-30d-5p IRS1 0.26829866064717 0.0228954180095085 -0.0263168100229603 0.888545775357123 MirTarget;miRNATAP -0.339533082056536 0.000607217075304893 NA NA NA hsa-miR-30e-5p IRS1 -0.284839730810255 0.0405852891523165 -0.0263168100229603 0.888545775357123 MirTarget -0.329370363733273 7.12476309853415e-05 NA NA NA hsa-miR-338-3p IRS1 -0.0138760121093551 0.956163634155272 -0.0263168100229603 0.888545775357123 miRanda -0.177536829162628 8.34833306587794e-05 NA NA NA hsa-miR-338-5p IRS1 -0.420442436641152 0.0583175290447746 -0.0263168100229603 0.888545775357123 PITA;miRNATAP -0.194016992676798 0.000160367166324534 NA NA NA hsa-miR-33a-5p IRS1 0.372183130885047 0.335617783855811 -0.0263168100229603 0.888545775357123 MirTarget -0.101805898228026 0.00053969172291249 NA NA NA hsa-miR-421 IRS1 1.26653675546617 2.35180826009926e-08 -0.0263168100229603 0.888545775357123 PITA;miRanda;miRNATAP -0.128077971840881 0.010096290912956 NA NA NA hsa-miR-429 IRS1 1.58250682050303 4.75828087352234e-05 -0.0263168100229603 0.888545775357123 miRanda;miRNATAP -0.147719329978381 3.09113541010604e-07 NA NA NA hsa-miR-590-3p IRS1 0.858742926831233 0.000127281269371976 -0.0263168100229603 0.888545775357123 PITA;miRanda;miRNATAP -0.188619268420665 0.000182468488665401 NA NA NA hsa-miR-628-5p IRS1 -0.0242002274581137 0.900266755757793 -0.0263168100229603 0.888545775357123 miRNATAP -0.119211446219462 0.0467433269577164 NA NA NA hsa-miR-660-5p IRS1 1.23607536548029 2.61099214897472e-10 -0.0263168100229603 0.888545775357123 MirTarget;miRNATAP -0.260107497774626 3.47527419323763e-06 NA NA NA hsa-miR-7-5p IRS1 1.20202447072014 0.000123775346787165 -0.0263168100229603 0.888545775357123 miRNAWalker2_validate;miRTarBase;MirTarget -0.188012121131238 7.24228504705438e-07 NA NA NA hsa-miR-96-5p IRS1 1.44821155854693 6.56312590328933e-06 -0.0263168100229603 0.888545775357123 MirTarget;TargetScan;miRNATAP -0.181578814190222 7.53770432461579e-07 21993544 hsa miR 96 up regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas; Altogether these results suggest that hsa-miR-96 may affect the growth of bladder cancer cells by up-regulating IRS1 and MAP4K1 levels functioning as a promising diagnostic marker in human bladder urothelial carcinomas bladder cancer hsa-miR-107 ITGA1 0.85152957824299 1.22369651446858e-11 0.115262071098885 0.568719105297938 miRanda -0.610030098392394 5.76329110207504e-11 NA NA NA hsa-miR-126-5p ITGA1 0.450893496822779 0.0112966412858755 0.115262071098885 0.568719105297938 mirMAP -0.446054243355303 3.2658570046565e-11 NA NA NA hsa-miR-140-5p ITGA1 0.132398579631585 0.457960134430787 0.115262071098885 0.568719105297938 miRanda -0.417570887513022 7.5055710295127e-10 NA NA NA hsa-miR-141-5p ITGA1 2.13747696823946 1.73124674554872e-11 0.115262071098885 0.568719105297938 MirTarget -0.364604959558584 2.55256665935546e-27 NA NA NA hsa-miR-181a-5p ITGA1 1.39352013383959 4.74824377258519e-17 0.115262071098885 0.568719105297938 mirMAP -0.258120437557254 0.000225932142125654 NA NA NA hsa-miR-181b-5p ITGA1 1.44365471425231 6.03807007335243e-15 0.115262071098885 0.568719105297938 mirMAP -0.250738659310382 6.97817865960767e-05 NA NA NA hsa-miR-186-5p ITGA1 0.35512789129261 0.0196931838168008 0.115262071098885 0.568719105297938 mirMAP -0.62733958543014 5.93533880157205e-16 NA NA NA hsa-miR-193a-3p ITGA1 0.148284355948959 0.379093889907371 0.115262071098885 0.568719105297938 miRanda -0.33476186671896 4.57507501475352e-06 NA NA NA hsa-miR-200a-5p ITGA1 2.19152245759943 3.17968183522514e-11 0.115262071098885 0.568719105297938 mirMAP -0.336574564423367 9.66249893880501e-25 NA NA NA hsa-miR-200b-3p ITGA1 2.06025765178663 3.07718049337497e-10 0.115262071098885 0.568719105297938 MirTarget -0.339222191248936 1.84422520780891e-24 NA NA NA hsa-miR-200b-5p ITGA1 0.934206940937576 0.00554096871767416 0.115262071098885 0.568719105297938 mirMAP -0.353160418925636 5.29166271400959e-24 NA NA NA hsa-miR-200c-3p ITGA1 1.74925752003763 3.42000026705311e-08 0.115262071098885 0.568719105297938 MirTarget -0.381874731749235 2.23374246789353e-29 NA NA NA hsa-miR-21-5p ITGA1 2.21515015440792 6.0468197386674e-49 0.115262071098885 0.568719105297938 mirMAP -0.227875606178553 0.000844966574930433 NA NA NA hsa-miR-30d-3p ITGA1 0.0608340295673737 0.708110230223927 0.115262071098885 0.568719105297938 MirTarget -0.456792241130854 1.00246488890687e-09 NA NA NA hsa-miR-30e-3p ITGA1 -0.444998679251398 0.000501880465265124 0.115262071098885 0.568719105297938 MirTarget -0.343654453742267 0.000405499205947633 NA NA NA hsa-miR-320a ITGA1 0.451741078692272 0.00893327237386749 0.115262071098885 0.568719105297938 miRanda -0.23672081993216 0.00092618464472879 NA NA NA hsa-miR-320b ITGA1 1.21733873788625 7.99882585998487e-07 0.115262071098885 0.568719105297938 miRanda -0.307114234840096 9.87542969728757e-11 NA NA NA hsa-miR-326 ITGA1 -0.552187708067123 0.039648668341622 0.115262071098885 0.568719105297938 miRanda -0.199986274735506 1.08100791772747e-05 NA NA NA hsa-miR-330-3p ITGA1 0.391166748754241 0.0581284813543685 0.115262071098885 0.568719105297938 mirMAP -0.419505466949644 1.94874617354836e-12 NA NA NA hsa-miR-330-5p ITGA1 0.621676971901542 0.00233177378595631 0.115262071098885 0.568719105297938 miRanda -0.475897644859247 5.82133047282576e-17 NA NA NA hsa-miR-335-3p ITGA1 2.29463721765513 4.1956113745077e-18 0.115262071098885 0.568719105297938 mirMAP -0.216729493106044 4.26824401857082e-07 NA NA NA hsa-miR-335-5p ITGA1 0.576542642348884 0.01886326850059 0.115262071098885 0.568719105297938 miRNAWalker2_validate -0.309451451190333 2.34127414810426e-10 NA NA NA hsa-miR-3607-3p ITGA1 0.479939234340415 0.251616873367277 0.115262071098885 0.568719105297938 MirTarget -0.176044605408269 2.47007861889181e-09 NA NA NA hsa-miR-361-5p ITGA1 0.538048008019709 1.61165802415302e-07 0.115262071098885 0.568719105297938 miRanda -0.293913720957527 0.0158667775583064 NA NA NA hsa-miR-362-3p ITGA1 0.994614346444282 4.39793878186399e-05 0.115262071098885 0.568719105297938 miRanda -0.396264523495062 6.50700258007287e-16 NA NA NA hsa-miR-374a-5p ITGA1 0.239597788731458 0.0202963000797544 0.115262071098885 0.568719105297938 mirMAP -0.478340741391133 9.78022741300089e-05 NA NA NA hsa-miR-374b-5p ITGA1 0.00249900187478502 0.985380083859555 0.115262071098885 0.568719105297938 mirMAP -0.304825724624992 0.000924234512261091 NA NA NA hsa-miR-421 ITGA1 1.26653675546617 2.35180826009926e-08 0.115262071098885 0.568719105297938 miRanda -0.227906704203525 1.74017417325201e-05 NA NA NA hsa-miR-429 ITGA1 1.58250682050303 4.75828087352234e-05 0.115262071098885 0.568719105297938 MirTarget;miRanda -0.301664808198101 1.26147140575013e-25 NA NA NA hsa-miR-452-5p ITGA1 0.612108901803716 0.0110020550949664 0.115262071098885 0.568719105297938 mirMAP -0.133066564010962 0.00926338193610914 NA NA NA hsa-miR-486-5p ITGA1 -1.52128065772506 4.50915908626354e-09 0.115262071098885 0.568719105297938 miRanda -0.166526371399694 0.000286436956233901 NA NA NA hsa-miR-493-5p ITGA1 1.32223598235404 3.01688809960418e-10 0.115262071098885 0.568719105297938 mirMAP -0.195770010724641 0.000555790495843826 NA NA NA hsa-miR-511-5p ITGA1 0.777051857549583 0.00217788750929907 0.115262071098885 0.568719105297938 MirTarget -0.225279410520272 2.30242018813875e-06 NA NA NA hsa-miR-576-5p ITGA1 0.872721964495849 5.20470410008775e-05 0.115262071098885 0.568719105297938 mirMAP -0.449170206048526 3.95842940280024e-17 NA NA NA hsa-miR-590-3p ITGA1 0.858742926831233 0.000127281269371976 0.115262071098885 0.568719105297938 miRanda;mirMAP -0.537131572172876 1.48407366935287e-27 NA NA NA hsa-miR-590-5p ITGA1 0.932604531809045 8.39043954167884e-05 0.115262071098885 0.568719105297938 miRanda;mirMAP -0.430319695046954 4.59483592649302e-19 NA NA NA hsa-miR-664a-3p ITGA1 -0.0290482945770787 0.844010225386475 0.115262071098885 0.568719105297938 mirMAP -0.272957906356175 0.00127568666500557 NA NA NA hsa-miR-7-1-3p ITGA1 0.94398354303717 7.5771319809992e-05 0.115262071098885 0.568719105297938 mirMAP -0.404165165970765 5.40415283656585e-17 NA NA NA hsa-let-7g-3p ITGA10 0.784640358146866 0.0110356862897896 -0.246637441238828 0.206017591376249 MirTarget;miRNATAP -0.215482934589729 8.63969506598154e-09 NA NA NA hsa-miR-107 ITGA10 0.85152957824299 1.22369651446858e-11 -0.246637441238828 0.206017591376249 miRanda -0.475977235307541 1.82125891371343e-07 NA NA NA hsa-miR-15a-5p ITGA10 1.07800995489566 4.32072598796529e-10 -0.246637441238828 0.206017591376249 MirTarget -0.433889197836424 2.27968535627325e-11 NA NA NA hsa-miR-15b-5p ITGA10 0.637819606405168 0.000580041575431604 -0.246637441238828 0.206017591376249 MirTarget -0.467782582298045 1.93056258357918e-14 NA NA NA hsa-miR-16-5p ITGA10 0.468459442059375 0.02635007201346 -0.246637441238828 0.206017591376249 MirTarget -0.415722898275786 1.15496956633378e-14 NA NA NA hsa-miR-30d-3p ITGA10 0.0608340295673737 0.708110230223927 -0.246637441238828 0.206017591376249 mirMAP -0.23529990176001 0.00148637691828895 NA NA NA hsa-miR-320b ITGA10 1.21733873788625 7.99882585998487e-07 -0.246637441238828 0.206017591376249 miRanda -0.206015485887806 1.07550898419275e-05 NA NA NA hsa-miR-324-5p ITGA10 0.800946351685734 0.00101337664367375 -0.246637441238828 0.206017591376249 miRanda;miRNATAP -0.274567984004215 6.69666670141655e-09 NA NA NA hsa-miR-335-5p ITGA10 0.576542642348884 0.01886326850059 -0.246637441238828 0.206017591376249 miRNAWalker2_validate -0.208949962258138 1.39316938116462e-05 NA NA NA hsa-miR-338-3p ITGA10 -0.0138760121093551 0.956163634155272 -0.246637441238828 0.206017591376249 miRanda -0.114706616658884 0.0154681122975927 NA NA NA hsa-miR-424-5p ITGA10 0.956135912596328 0.00035164943928494 -0.246637441238828 0.206017591376249 MirTarget -0.229819899076067 1.04693150605075e-07 NA NA NA hsa-miR-429 ITGA10 1.58250682050303 4.75828087352234e-05 -0.246637441238828 0.206017591376249 miRanda;miRNATAP -0.216832383346549 1.19936032990493e-13 NA NA NA hsa-miR-484 ITGA10 0.401753773460753 0.0490851523101605 -0.246637441238828 0.206017591376249 miRNATAP -0.362028383077928 1.71266509988192e-10 NA NA NA hsa-miR-940 ITGA10 1.3080677738253 2.0056085433599e-05 -0.246637441238828 0.206017591376249 MirTarget;miRNATAP -0.223412764308447 5.45653351142743e-09 NA NA NA hsa-miR-29a-3p ITGA11 -0.235052170104117 0.138527567930958 1.79059529437117 6.48067442464484e-12 miRNAWalker2_validate;miRTarBase -0.264796956873752 0.0125848334678668 NA NA NA hsa-miR-129-5p ITGA2 -1.61803714443871 4.93214379865694e-06 1.17725809498257 2.34860811208909e-08 miRanda -0.138259344175858 0.000194001462543248 NA NA NA hsa-miR-130a-3p ITGA2 0.218018009582956 0.274232880676821 1.17725809498257 2.34860811208909e-08 mirMAP -0.14362975198114 0.0319763420208459 NA NA NA hsa-miR-139-5p ITGA2 -1.41674256628297 4.51005988644234e-14 1.17725809498257 2.34860811208909e-08 PITA;miRanda -0.286374997547596 1.77246050042894e-05 NA NA NA hsa-miR-195-5p ITGA2 -1.07154705036962 4.16544134775761e-08 1.17725809498257 2.34860811208909e-08 MirTarget;miRNATAP -0.407639234478228 2.37972891134613e-10 NA NA NA hsa-miR-26a-5p ITGA2 -0.507487084157331 3.23715933371269e-05 1.17725809498257 2.34860811208909e-08 mirMAP -0.456573795494557 2.54919704796471e-05 NA NA NA hsa-miR-26b-5p ITGA2 -0.499493687076043 0.0118149973400486 1.17725809498257 2.34860811208909e-08 mirMAP -0.177788501157782 0.00780697232610213 NA NA NA hsa-miR-27b-3p ITGA2 -0.439806942644624 0.000523870009254693 1.17725809498257 2.34860811208909e-08 miRNATAP -0.264580927820324 0.0124403860159241 NA NA NA hsa-miR-30a-5p ITGA2 -0.742755040631906 3.79943871404435e-05 1.17725809498257 2.34860811208909e-08 miRNAWalker2_validate;mirMAP -0.233956133766592 0.00130047081191859 NA NA NA hsa-miR-30b-5p ITGA2 -0.0106833209203501 0.954966272944722 1.17725809498257 2.34860811208909e-08 mirMAP -0.195823673771214 0.0055092223983798 NA NA NA hsa-miR-30c-5p ITGA2 -0.172645077009891 0.276411433016536 1.17725809498257 2.34860811208909e-08 mirMAP -0.296486998225948 0.000425239952139251 NA NA NA hsa-miR-30e-5p ITGA2 -0.284839730810255 0.0405852891523165 1.17725809498257 2.34860811208909e-08 mirMAP -0.213282644641173 0.0277241814079079 NA NA NA hsa-miR-374b-5p ITGA2 0.00249900187478502 0.985380083859555 1.17725809498257 2.34860811208909e-08 MirTarget -0.345338691475731 0.00046340788284457 NA NA NA hsa-miR-497-5p ITGA2 -0.486115215577409 0.00973897247186318 1.17725809498257 2.34860811208909e-08 MirTarget;miRNATAP -0.266080642851356 0.00014681768311383 NA NA NA hsa-miR-664a-3p ITGA2 -0.0290482945770787 0.844010225386475 1.17725809498257 2.34860811208909e-08 MirTarget;mirMAP -0.258805923116716 0.00451518332668972 NA NA NA hsa-miR-181c-5p ITGA3 0.455531227606462 0.00194067309813448 0.131715315790766 0.485779689129617 miRNATAP -0.238519723388119 0.00249761364131665 NA NA NA hsa-miR-107 ITGA5 0.85152957824299 1.22369651446858e-11 0.451610603015354 0.0352433294585663 PITA;miRanda -0.5593217426226 2.43640063238668e-08 NA NA NA hsa-miR-148a-3p ITGA5 -0.18108394434325 0.495345303586758 0.451610603015354 0.0352433294585663 miRNATAP -0.397315274410076 1.59240256420042e-17 NA NA NA hsa-miR-148b-3p ITGA5 0.719517328390822 3.51245964668412e-05 0.451610603015354 0.0352433294585663 miRNAWalker2_validate -0.517149902626302 7.29744306029615e-13 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 2.08412478942637 1.08931431254487e-10 0.451610603015354 0.0352433294585663 miRNAWalker2_validate -0.262508236266232 3.15413351773057e-12 NA NA NA hsa-miR-185-3p ITGA5 1.38509197368746 3.93425296894499e-10 0.451610603015354 0.0352433294585663 miRNATAP -0.253525422309983 1.63226067148619e-05 NA NA NA hsa-miR-193a-3p ITGA5 0.148284355948959 0.379093889907371 0.451610603015354 0.0352433294585663 miRanda -0.208847585043552 0.00805122278267987 NA NA NA hsa-miR-194-3p ITGA5 1.91477879150304 2.49480074178753e-07 0.451610603015354 0.0352433294585663 miRNATAP -0.211631201255028 9.4529588769784e-10 NA NA NA hsa-miR-25-3p ITGA5 0.948739680210032 3.62304579611938e-09 0.451610603015354 0.0352433294585663 miRNATAP -0.424670846530583 6.23162011988932e-08 NA NA NA hsa-miR-26a-5p ITGA5 -0.507487084157331 3.23715933371269e-05 0.451610603015354 0.0352433294585663 miRNATAP -0.33993245069084 0.00171387440154057 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26b-5p ITGA5 -0.499493687076043 0.0118149973400486 0.451610603015354 0.0352433294585663 miRNATAP -0.300986810454986 4.2310525418394e-06 NA NA NA hsa-miR-27a-3p ITGA5 0.523219911315699 0.000116410279757859 0.451610603015354 0.0352433294585663 miRNATAP -0.21119940689353 0.0304970136020727 NA NA NA hsa-miR-3065-3p ITGA5 -0.00685158653722073 0.979081293235379 0.451610603015354 0.0352433294585663 miRNATAP -0.189874415309209 0.000148608101814451 NA NA NA hsa-miR-30d-5p ITGA5 0.26829866064717 0.0228954180095085 0.451610603015354 0.0352433294585663 miRNATAP -0.52321163138136 3.37216806122342e-06 NA NA NA hsa-miR-32-5p ITGA5 0.425717775201634 0.0402079308210921 0.451610603015354 0.0352433294585663 miRNATAP -0.424299170586814 3.6994235751827e-12 NA NA NA hsa-miR-326 ITGA5 -0.552187708067123 0.039648668341622 0.451610603015354 0.0352433294585663 PITA;miRanda;miRNATAP -0.113918635936623 0.0201845193257096 NA NA NA hsa-miR-330-5p ITGA5 0.621676971901542 0.00233177378595631 0.451610603015354 0.0352433294585663 PITA;miRanda;miRNATAP -0.295756249536981 2.99867234194542e-06 27633518 MicroRNA 330 5p negatively regulates ITGA5 expression in human colorectal cancer; These results suggest that downregulation of miR-330-5p expression may affect CRC development via modulation of ITGA5 expression colorectal cancer hsa-miR-338-3p ITGA5 -0.0138760121093551 0.956163634155272 0.451610603015354 0.0352433294585663 miRanda -0.174586718756762 0.000784856938544767 NA NA NA hsa-miR-429 ITGA5 1.58250682050303 4.75828087352234e-05 0.451610603015354 0.0352433294585663 miRNATAP -0.243184306728994 4.17212824953235e-14 NA NA NA hsa-miR-484 ITGA5 0.401753773460753 0.0490851523101605 0.451610603015354 0.0352433294585663 miRNAWalker2_validate -0.292544550324332 4.38158168466712e-06 NA NA NA hsa-miR-629-3p ITGA5 0.597278340934362 0.0508108703940013 0.451610603015354 0.0352433294585663 miRNATAP -0.265144442548828 3.04066487151883e-09 NA NA NA hsa-miR-92a-3p ITGA5 1.06124545165614 6.51550014372282e-08 0.451610603015354 0.0352433294585663 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372952592294832 5.45546192045136e-09 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-98-5p ITGA5 0.72508924193932 6.07191196761022e-10 0.451610603015354 0.0352433294585663 miRNAWalker2_validate -0.394172803806321 0.000368990810123783 NA NA NA hsa-miR-125b-2-3p ITGA6 -0.0327216991692278 0.904317305131546 0.77491551247973 1.24015958097678e-05 mirMAP -0.196155472485239 1.13765813187589e-06 NA NA NA hsa-miR-129-5p ITGA6 -1.61803714443871 4.93214379865694e-06 0.77491551247973 1.24015958097678e-05 PITA;miRanda -0.125020222037537 4.80583628853196e-05 NA NA NA hsa-miR-30a-5p ITGA6 -0.742755040631906 3.79943871404435e-05 0.77491551247973 1.24015958097678e-05 miRNAWalker2_validate -0.277899904544639 3.39609467126389e-06 NA NA NA hsa-miR-326 ITGA7 -0.552187708067123 0.039648668341622 -0.807132749170638 0.00735144272254076 miRanda -0.248125431357726 0.000296757258700935 NA NA NA hsa-miR-330-5p ITGA7 0.621676971901542 0.00233177378595631 -0.807132749170638 0.00735144272254076 miRanda -0.765183896627493 1.18499712329642e-19 NA NA NA hsa-miR-339-5p ITGA7 0.51232205151031 0.0560469213103598 -0.807132749170638 0.00735144272254076 miRanda -0.498224831210104 3.56760219599811e-14 NA NA NA hsa-miR-362-3p ITGA7 0.994614346444282 4.39793878186399e-05 -0.807132749170638 0.00735144272254076 miRanda -0.576619725644112 5.87630569214555e-15 NA NA NA hsa-miR-126-5p ITGA8 0.450893496822779 0.0112966412858755 -1.91389446067294 3.08011993269904e-08 mirMAP -0.336710089492531 0.00597788175264323 NA NA NA hsa-miR-130b-3p ITGA8 1.29757792612022 1.70655148591568e-06 -1.91389446067294 3.08011993269904e-08 mirMAP -0.641864889080083 3.07540964520211e-18 NA NA NA hsa-miR-154-3p ITGA8 1.27058912874349 3.17904395436332e-08 -1.91389446067294 3.08011993269904e-08 TargetScan -0.526023049782962 7.80772111750373e-08 NA NA NA hsa-miR-16-1-3p ITGA8 1.23864765632542 1.24544799589822e-08 -1.91389446067294 3.08011993269904e-08 mirMAP -0.837289296973083 5.15056939230192e-19 NA NA NA hsa-miR-183-5p ITGA8 2.08412478942637 1.08931431254487e-10 -1.91389446067294 3.08011993269904e-08 miRNAWalker2_validate -0.558513541677476 1.6334610963548e-20 NA NA NA hsa-miR-19b-1-5p ITGA8 1.78323584062047 7.55784857614623e-15 -1.91389446067294 3.08011993269904e-08 mirMAP -0.882947440245455 1.64083885063647e-27 NA NA NA hsa-miR-21-5p ITGA8 2.21515015440792 6.0468197386674e-49 -1.91389446067294 3.08011993269904e-08 mirMAP -0.952913612008529 5.57352645287147e-17 NA NA NA hsa-miR-301a-3p ITGA8 1.22580753116505 5.84016077664577e-09 -1.91389446067294 3.08011993269904e-08 mirMAP -0.724277486210536 4.40442801584605e-14 NA NA NA hsa-miR-30b-5p ITGA8 -0.0106833209203501 0.954966272944722 -1.91389446067294 3.08011993269904e-08 mirMAP -0.378015815127387 0.00105387671357551 NA NA NA hsa-miR-30c-5p ITGA8 -0.172645077009891 0.276411433016536 -1.91389446067294 3.08011993269904e-08 mirMAP -0.299456043906119 0.0312558412502156 NA NA NA hsa-miR-30d-5p ITGA8 0.26829866064717 0.0228954180095085 -1.91389446067294 3.08011993269904e-08 mirMAP -0.925969072134643 6.04167948578505e-07 NA NA NA hsa-miR-335-3p ITGA8 2.29463721765513 4.1956113745077e-18 -1.91389446067294 3.08011993269904e-08 mirMAP -0.595661020170064 2.31149219290143e-16 NA NA NA hsa-miR-33a-5p ITGA8 0.372183130885047 0.335617783855811 -1.91389446067294 3.08011993269904e-08 mirMAP -0.300240632382474 4.48173997088012e-08 NA NA NA hsa-miR-409-3p ITGA8 1.02296003511803 1.54748197930307e-08 -1.91389446067294 3.08011993269904e-08 mirMAP -0.66483269120956 6.91803242299293e-09 NA NA NA hsa-miR-454-3p ITGA8 0.823770738595667 1.30339728183332e-05 -1.91389446067294 3.08011993269904e-08 mirMAP -0.689582702756626 4.38030784012866e-10 NA NA NA hsa-miR-577 ITGA8 0.615893340074725 0.210494450869356 -1.91389446067294 3.08011993269904e-08 mirMAP -0.262558233255599 2.31046981067403e-08 NA NA NA hsa-miR-590-5p ITGA8 0.932604531809045 8.39043954167884e-05 -1.91389446067294 3.08011993269904e-08 mirMAP -0.711570140523214 1.05398125032997e-16 NA NA NA hsa-miR-7-1-3p ITGA8 0.94398354303717 7.5771319809992e-05 -1.91389446067294 3.08011993269904e-08 mirMAP -0.687955918792645 7.52771718497732e-16 NA NA NA hsa-miR-103a-2-5p ITGA9 0.668868218338912 0.0220512854713701 -0.825924039856462 0.00174155829133973 mirMAP -0.474045509245264 5.97975083377113e-15 NA NA NA hsa-miR-126-5p ITGA9 0.450893496822779 0.0112966412858755 -0.825924039856462 0.00174155829133973 mirMAP -0.419445894306114 3.51098248977031e-06 NA NA NA hsa-miR-141-5p ITGA9 2.13747696823946 1.73124674554872e-11 -0.825924039856462 0.00174155829133973 MirTarget -0.458715397150148 1.47861761539656e-24 NA NA NA hsa-miR-142-5p ITGA9 1.08445947321046 0.000126372881543671 -0.825924039856462 0.00174155829133973 mirMAP -0.287739604708264 2.38502927105591e-07 NA NA NA hsa-miR-181a-5p ITGA9 1.39352013383959 4.74824377258519e-17 -0.825924039856462 0.00174155829133973 mirMAP -0.599067048424117 2.20721008596283e-11 NA NA NA hsa-miR-181b-5p ITGA9 1.44365471425231 6.03807007335243e-15 -0.825924039856462 0.00174155829133973 mirMAP -0.566608389326746 1.88947663651612e-12 NA NA NA hsa-miR-194-3p ITGA9 1.91477879150304 2.49480074178753e-07 -0.825924039856462 0.00174155829133973 MirTarget -0.254179837415357 3.04158171408953e-09 NA NA NA hsa-miR-194-5p ITGA9 2.24386881692218 9.35116329002209e-11 -0.825924039856462 0.00174155829133973 miRNAWalker2_validate;miRTarBase -0.304755562790261 2.04883725664225e-12 NA NA NA hsa-miR-200b-3p ITGA9 2.06025765178663 3.07718049337497e-10 -0.825924039856462 0.00174155829133973 mirMAP -0.457920037358817 6.75510224611362e-26 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-20a-3p ITGA9 0.703027135708586 0.022464856696655 -0.825924039856462 0.00174155829133973 mirMAP -0.42719996582168 7.79541431140104e-17 NA NA NA hsa-miR-223-3p ITGA9 1.08589180128329 0.000115241553609245 -0.825924039856462 0.00174155829133973 mirMAP -0.304280017536736 4.90140535172186e-08 24333181 Our aim was to investigate miR-223 regulation in HCC miR-223 and integrin αV dysregulation were verified in 57 HCC specimens; Enhanced miR-223 expression had a negative effect on integrin αV-mediated cell migration; Further analysis demonstrated that integrin αV is negatively regulated by miR-223 cell migration liver cancer hsa-miR-29a-5p ITGA9 1.00715634051951 4.47499137997344e-07 -0.825924039856462 0.00174155829133973 mirMAP -0.662680508998161 9.65272849234337e-19 26903137 We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1 gastric cancer hsa-miR-29b-1-5p ITGA9 1.27585983480192 1.70509960024426e-05 -0.825924039856462 0.00174155829133973 mirMAP -0.453246375521064 3.75743483501874e-19 NA NA NA hsa-miR-324-5p ITGA9 0.800946351685734 0.00101337664367375 -0.825924039856462 0.00174155829133973 miRanda -0.516723660449521 1.47760278138859e-16 NA NA NA hsa-miR-330-3p ITGA9 0.391166748754241 0.0581284813543685 -0.825924039856462 0.00174155829133973 mirMAP -0.461515179560972 6.9254504992835e-09 NA NA NA hsa-miR-338-5p ITGA9 -0.420442436641152 0.0583175290447746 -0.825924039856462 0.00174155829133973 mirMAP -0.234176544067375 0.001384033713675 27431198 miR 338 inhibits the metastasis of lung cancer by targeting integrin β3; Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-33a-3p ITGA9 0.21453033253985 0.371591474252951 -0.825924039856462 0.00174155829133973 mirMAP -0.467559818800328 8.14029662242623e-12 NA NA NA hsa-miR-33a-5p ITGA9 0.372183130885047 0.335617783855811 -0.825924039856462 0.00174155829133973 mirMAP -0.296229645040263 1.56463862864378e-13 NA NA NA hsa-miR-340-5p ITGA9 0.344103676703511 0.0160638942614091 -0.825924039856462 0.00174155829133973 MirTarget;mirMAP -0.235274915787545 0.0415821646264597 NA NA NA hsa-miR-369-3p ITGA9 0.644921905467686 0.00104986428608648 -0.825924039856462 0.00174155829133973 mirMAP -0.329084903964194 5.98064110263218e-05 NA NA NA hsa-miR-421 ITGA9 1.26653675546617 2.35180826009926e-08 -0.825924039856462 0.00174155829133973 mirMAP -0.453833745576503 2.85463013950866e-11 NA NA NA hsa-miR-429 ITGA9 1.58250682050303 4.75828087352234e-05 -0.825924039856462 0.00174155829133973 miRanda -0.39292572144023 5.59742578217937e-25 NA NA NA hsa-miR-452-5p ITGA9 0.612108901803716 0.0110020550949664 -0.825924039856462 0.00174155829133973 mirMAP -0.208457990756374 0.00191116445181397 NA NA NA hsa-miR-484 ITGA9 0.401753773460753 0.0490851523101605 -0.825924039856462 0.00174155829133973 miRNAWalker2_validate -0.572552229829884 5.91102831275376e-14 NA NA NA hsa-miR-501-5p ITGA9 1.59306197632625 2.04856600619363e-09 -0.825924039856462 0.00174155829133973 MirTarget -0.503124010620741 6.97939617838749e-18 NA NA NA hsa-miR-542-3p ITGA9 1.12416854979951 1.02649534578738e-12 -0.825924039856462 0.00174155829133973 miRanda -0.371407492795566 0.000173539630986779 NA NA NA hsa-miR-576-5p ITGA9 0.872721964495849 5.20470410008775e-05 -0.825924039856462 0.00174155829133973 mirMAP -0.706028143836609 3.00265840735672e-25 NA NA NA hsa-miR-589-3p ITGA9 1.00357906465313 8.20399071001461e-05 -0.825924039856462 0.00174155829133973 mirMAP -0.579614805141257 6.13346764636117e-21 NA NA NA hsa-miR-590-3p ITGA9 0.858742926831233 0.000127281269371976 -0.825924039856462 0.00174155829133973 miRanda -0.642883986048017 4.06776775322923e-22 NA NA NA hsa-miR-590-5p ITGA9 0.932604531809045 8.39043954167884e-05 -0.825924039856462 0.00174155829133973 miRanda -0.5684588948399 3.44509345346614e-19 NA NA NA hsa-miR-664a-3p ITGA9 -0.0290482945770787 0.844010225386475 -0.825924039856462 0.00174155829133973 MirTarget -0.362653836511744 0.00115254362292576 NA NA NA hsa-miR-877-5p ITGA9 1.86786864338556 8.44059777969251e-10 -0.825924039856462 0.00174155829133973 mirMAP -0.467384903545224 4.76742944533573e-19 NA NA NA hsa-let-7a-3p ITGAV 0.283468597868531 0.127007787220086 0.337483830372149 0.0100159754433787 MirTarget -0.212461328827975 6.78684333925609e-07 NA NA NA hsa-let-7b-3p ITGAV 0.377956364821509 0.0061730103051373 0.337483830372149 0.0100159754433787 MirTarget -0.178733903811449 0.00235141344620099 NA NA NA hsa-let-7f-1-3p ITGAV 1.09636075438131 3.42037366931931e-10 0.337483830372149 0.0100159754433787 MirTarget -0.156653780913852 0.000433774325634013 NA NA NA hsa-miR-10b-3p ITGAV 0.448860145188521 0.00703361939318676 0.337483830372149 0.0100159754433787 MirTarget -0.132659177975013 0.00625858248331786 NA NA NA hsa-miR-141-3p ITGAV 1.76274853293464 9.99331900755725e-07 0.337483830372149 0.0100159754433787 MirTarget -0.113109926878241 1.14265147275789e-07 NA NA NA hsa-miR-142-5p ITGAV 1.08445947321046 0.000126372881543671 0.337483830372149 0.0100159754433787 MirTarget;PITA -0.110445710453909 7.03014005381004e-05 NA NA NA hsa-miR-16-2-3p ITGAV 0.869267463341732 0.000785361809327569 0.337483830372149 0.0100159754433787 mirMAP -0.12121514727902 7.02799897833912e-05 NA NA NA hsa-miR-186-5p ITGAV 0.35512789129261 0.0196931838168008 0.337483830372149 0.0100159754433787 mirMAP -0.176636447122188 0.000867292164267155 NA NA NA hsa-miR-25-3p ITGAV 0.948739680210032 3.62304579611938e-09 0.337483830372149 0.0100159754433787 MirTarget;miRNATAP -0.202638299401777 2.88605337390477e-05 NA NA NA hsa-miR-29a-5p ITGAV 1.00715634051951 4.47499137997344e-07 0.337483830372149 0.0100159754433787 mirMAP -0.114836208332911 0.00363615379527472 NA NA NA hsa-miR-30e-3p ITGAV -0.444998679251398 0.000501880465265124 0.337483830372149 0.0100159754433787 mirMAP -0.256993276676523 4.44989349408738e-05 NA NA NA hsa-miR-32-5p ITGAV 0.425717775201634 0.0402079308210921 0.337483830372149 0.0100159754433787 miRNAWalker2_validate;MirTarget;miRNATAP -0.255681699840391 7.51161783382626e-12 NA NA NA hsa-miR-331-5p ITGAV 0.703863188605486 4.25406757208802e-05 0.337483830372149 0.0100159754433787 PITA -0.136730335579703 0.0033252040110944 NA NA NA hsa-miR-33a-3p ITGAV 0.21453033253985 0.371591474252951 0.337483830372149 0.0100159754433787 MirTarget -0.204916699110769 1.87904754355213e-09 NA NA NA hsa-miR-340-5p ITGAV 0.344103676703511 0.0160638942614091 0.337483830372149 0.0100159754433787 MirTarget -0.168706470529525 0.00295628403784668 NA NA NA hsa-miR-374a-5p ITGAV 0.239597788731458 0.0202963000797544 0.337483830372149 0.0100159754433787 mirMAP -0.273444429946994 0.000641692096378712 NA NA NA hsa-miR-374b-5p ITGAV 0.00249900187478502 0.985380083859555 0.337483830372149 0.0100159754433787 mirMAP -0.248279108177145 2.98872411580522e-05 NA NA NA hsa-miR-429 ITGAV 1.58250682050303 4.75828087352234e-05 0.337483830372149 0.0100159754433787 miRanda -0.100120371770809 7.74334886055144e-07 NA NA NA hsa-miR-550a-3p ITGAV 0.691643089167284 0.0329454607437103 0.337483830372149 0.0100159754433787 miRNATAP -0.12251569549735 9.67000420751277e-06 NA NA NA hsa-miR-576-5p ITGAV 0.872721964495849 5.20470410008775e-05 0.337483830372149 0.0100159754433787 PITA;mirMAP -0.113702264903402 0.00197275230307194 NA NA NA hsa-miR-590-3p ITGAV 0.858742926831233 0.000127281269371976 0.337483830372149 0.0100159754433787 MirTarget;PITA;miRanda -0.179380986513993 2.77518916239459e-07 NA NA NA hsa-miR-7-1-3p ITGAV 0.94398354303717 7.5771319809992e-05 0.337483830372149 0.0100159754433787 mirMAP -0.149801259371665 5.07709289445698e-06 NA NA NA hsa-miR-92a-3p ITGAV 1.06124545165614 6.51550014372282e-08 0.337483830372149 0.0100159754433787 MirTarget;miRNATAP -0.143720647684509 0.000307574927299622 NA NA NA hsa-miR-16-2-3p ITGB1 0.869267463341732 0.000785361809327569 0.523596429686159 0.000169768671621539 mirMAP -0.244912840384237 5.04735568991576e-15 NA NA NA hsa-miR-183-5p ITGB1 2.08412478942637 1.08931431254487e-10 0.523596429686159 0.000169768671621539 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131986789220149 1.4627928835727e-07 NA NA NA hsa-miR-186-5p ITGB1 0.35512789129261 0.0196931838168008 0.523596429686159 0.000169768671621539 miRNAWalker2_validate -0.419861530750727 1.01375733225069e-14 NA NA NA hsa-miR-192-5p ITGB1 2.0867723747501 3.57854249239079e-08 0.523596429686159 0.000169768671621539 miRNAWalker2_validate -0.150999493689047 9.20856253461791e-13 NA NA NA hsa-miR-193a-3p ITGB1 0.148284355948959 0.379093889907371 0.523596429686159 0.000169768671621539 miRanda -0.150189587194463 0.00351353969237572 NA NA NA hsa-miR-25-3p ITGB1 0.948739680210032 3.62304579611938e-09 0.523596429686159 0.000169768671621539 miRNAWalker2_validate -0.258819136487108 5.01060405361773e-07 NA NA NA hsa-miR-29a-3p ITGB1 -0.235052170104117 0.138527567930958 0.523596429686159 0.000169768671621539 MirTarget;miRNATAP -0.418232596786111 7.85778904453293e-16 26903137 hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA 29a; We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 ITGB1; Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo metastasis gastric cancer hsa-miR-29b-3p ITGB1 0.0225365195743876 0.914313337784307 0.523596429686159 0.000169768671621539 MirTarget;miRNATAP -0.31369596028085 1.07749662663566e-15 NA NA NA hsa-miR-29c-3p ITGB1 -1.34143813218298 2.77493790306384e-12 0.523596429686159 0.000169768671621539 MirTarget;miRNATAP -0.306193200161173 1.0772695113531e-13 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-320a ITGB1 0.451741078692272 0.00893327237386749 0.523596429686159 0.000169768671621539 miRanda -0.135768187665576 0.00654636040187689 NA NA NA hsa-miR-320b ITGB1 1.21733873788625 7.99882585998487e-07 0.523596429686159 0.000169768671621539 miRanda -0.174779928659944 1.82917074423055e-07 NA NA NA hsa-miR-3607-3p ITGB1 0.479939234340415 0.251616873367277 0.523596429686159 0.000169768671621539 MirTarget -0.131756620174766 1.14742448994513e-10 NA NA NA hsa-miR-369-3p ITGB1 0.644921905467686 0.00104986428608648 0.523596429686159 0.000169768671621539 miRNATAP -0.155115934561466 0.000360983626083641 NA NA NA hsa-miR-374b-3p ITGB1 0.286271228061054 0.169086077672581 0.523596429686159 0.000169768671621539 MirTarget -0.159702509148252 0.000182065455877401 NA NA NA hsa-miR-375 ITGB1 -0.348733074320394 0.47719066431766 0.523596429686159 0.000169768671621539 miRNAWalker2_validate -0.143267239354357 2.09138948366305e-18 NA NA NA hsa-miR-429 ITGB1 1.58250682050303 4.75828087352234e-05 0.523596429686159 0.000169768671621539 miRanda -0.179835207809611 3.59715682805073e-18 NA NA NA hsa-miR-542-3p ITGB1 1.12416854979951 1.02649534578738e-12 0.523596429686159 0.000169768671621539 PITA;miRanda -0.112044387704876 0.0337364137467227 NA NA NA hsa-miR-590-3p ITGB1 0.858742926831233 0.000127281269371976 0.523596429686159 0.000169768671621539 miRanda;mirMAP -0.302863933015461 3.0180460253268e-17 NA NA NA hsa-miR-590-5p ITGB1 0.932604531809045 8.39043954167884e-05 0.523596429686159 0.000169768671621539 miRanda -0.254308837251776 1.32700002913145e-13 NA NA NA hsa-miR-7-1-3p ITGB1 0.94398354303717 7.5771319809992e-05 0.523596429686159 0.000169768671621539 MirTarget;mirMAP -0.244570464047019 8.32889426436262e-13 NA NA NA hsa-let-7d-5p ITGB3 0.686819803681087 1.08347860862215e-06 -0.0112515540123894 0.957514601637104 MirTarget -0.585062581494334 2.94135499459232e-11 NA NA NA hsa-let-7g-5p ITGB3 0.296128761926282 0.0296823495976068 -0.0112515540123894 0.957514601637104 MirTarget;miRNATAP -0.576172627381332 6.80114518075399e-10 NA NA NA hsa-miR-146b-5p ITGB3 2.23105707690238 3.83997814011313e-23 -0.0112515540123894 0.957514601637104 miRanda -0.195758557971665 0.000176176544530511 NA NA NA hsa-miR-185-5p ITGB3 1.20157041272762 3.03584066444936e-15 -0.0112515540123894 0.957514601637104 MirTarget -0.504750041689336 1.23244024325219e-10 NA NA NA hsa-miR-186-5p ITGB3 0.35512789129261 0.0196931838168008 -0.0112515540123894 0.957514601637104 mirMAP -0.528599297515221 1.75088884894846e-10 NA NA NA hsa-miR-18a-3p ITGB3 1.42489363201958 4.87914808744785e-05 -0.0112515540123894 0.957514601637104 miRNATAP -0.255231429843625 7.82795644204693e-11 NA NA NA hsa-miR-1976 ITGB3 0.888680419203938 2.16642020734521e-05 -0.0112515540123894 0.957514601637104 MirTarget -0.375543779606352 1.54654545842767e-09 NA NA NA hsa-miR-221-3p ITGB3 1.11809809289021 6.56903442847056e-08 -0.0112515540123894 0.957514601637104 MirTarget -0.459328223830272 2.0376417216123e-15 NA NA NA hsa-miR-222-3p ITGB3 1.50650995841483 1.51287294049382e-09 -0.0112515540123894 0.957514601637104 MirTarget -0.408276620984105 3.87085696339068e-18 NA NA NA hsa-miR-30b-5p ITGB3 -0.0106833209203501 0.954966272944722 -0.0112515540123894 0.957514601637104 mirMAP -0.287615125217986 2.33010239210983e-05 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 -0.172645077009891 0.276411433016536 -0.0112515540123894 0.957514601637104 miRNAWalker2_validate;mirMAP;miRNATAP -0.203538668103918 0.0134497352131007 NA NA NA hsa-miR-30d-5p ITGB3 0.26829866064717 0.0228954180095085 -0.0112515540123894 0.957514601637104 miRNATAP -0.436238971110886 8.55311738203963e-05 NA NA NA hsa-miR-320a ITGB3 0.451741078692272 0.00893327237386749 -0.0112515540123894 0.957514601637104 miRanda -0.209193006025697 0.00519567924292568 NA NA NA hsa-miR-320b ITGB3 1.21733873788625 7.99882585998487e-07 -0.0112515540123894 0.957514601637104 miRanda -0.287755647144278 8.51977703792008e-09 NA NA NA hsa-miR-3607-3p ITGB3 0.479939234340415 0.251616873367277 -0.0112515540123894 0.957514601637104 MirTarget;mirMAP;miRNATAP -0.116590913846207 0.000210832582444517 NA NA NA hsa-miR-409-3p ITGB3 1.02296003511803 1.54748197930307e-08 -0.0112515540123894 0.957514601637104 MirTarget -0.138847379003718 0.0472923550504644 NA NA NA hsa-miR-425-5p ITGB3 0.865319550452351 0.000902803064763851 -0.0112515540123894 0.957514601637104 MirTarget -0.323725733344828 7.15852450788484e-12 NA NA NA hsa-miR-429 ITGB3 1.58250682050303 4.75828087352234e-05 -0.0112515540123894 0.957514601637104 miRanda -0.252392376262655 7.98453822694081e-16 NA NA NA hsa-miR-589-5p ITGB3 1.20000320800112 1.34209467040505e-13 -0.0112515540123894 0.957514601637104 MirTarget -0.413207835855374 3.29919001837065e-08 NA NA NA hsa-miR-590-3p ITGB3 0.858742926831233 0.000127281269371976 -0.0112515540123894 0.957514601637104 PITA;miRanda -0.407275830831357 8.27842980853625e-14 NA NA NA hsa-miR-590-5p ITGB3 0.932604531809045 8.39043954167884e-05 -0.0112515540123894 0.957514601637104 miRanda -0.360635086990455 3.41726544625595e-12 NA NA NA hsa-miR-98-5p ITGB3 0.72508924193932 6.07191196761022e-10 -0.0112515540123894 0.957514601637104 miRNAWalker2_validate;MirTarget -0.545659118335748 3.56529266989525e-07 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-155-5p ITGB5 0.708423342476697 0.00686702252429413 0.356193384860324 0.00663584424218538 miRNAWalker2_validate -0.114690343686882 0.000155979601780455 NA NA NA hsa-miR-378a-5p ITGB5 -0.684033095877066 0.000471076679969606 0.356193384860324 0.00663584424218538 MirTarget -0.256615261569471 9.34510723997358e-11 NA NA NA hsa-miR-484 ITGB5 0.401753773460753 0.0490851523101605 0.356193384860324 0.00663584424218538 miRNATAP -0.127705533914495 0.00117923340852957 NA NA NA hsa-miR-486-5p ITGB5 -1.52128065772506 4.50915908626354e-09 0.356193384860324 0.00663584424218538 miRanda -0.119527414617324 6.16153696310104e-05 NA NA NA hsa-miR-106a-5p ITGB8 0.587427028487119 0.00838999163993323 0.97999687178823 5.58178677335184e-06 MirTarget;miRNATAP -0.138514339333012 0.0214553520410674 NA NA NA hsa-miR-130a-3p ITGB8 0.218018009582956 0.274232880676821 0.97999687178823 5.58178677335184e-06 MirTarget;miRNATAP -0.179822765765575 0.00792208234788877 NA NA NA hsa-miR-130b-3p ITGB8 1.29757792612022 1.70655148591568e-06 0.97999687178823 5.58178677335184e-06 MirTarget;miRNATAP -0.117469730693795 0.0156398187071996 NA NA NA hsa-miR-139-5p ITGB8 -1.41674256628297 4.51005988644234e-14 0.97999687178823 5.58178677335184e-06 PITA;miRanda;miRNATAP -0.19131178803895 0.00510068629533974 NA NA NA hsa-miR-142-5p ITGB8 1.08445947321046 0.000126372881543671 0.97999687178823 5.58178677335184e-06 PITA -0.174227767485621 0.000182135170766565 NA NA NA hsa-miR-148a-3p ITGB8 -0.18108394434325 0.495345303586758 0.97999687178823 5.58178677335184e-06 miRNATAP -0.191878041534089 0.000134872612874154 NA NA NA hsa-miR-26a-5p ITGB8 -0.507487084157331 3.23715933371269e-05 0.97999687178823 5.58178677335184e-06 MirTarget -0.639051093890409 3.44992945056869e-09 NA NA NA hsa-miR-26b-5p ITGB8 -0.499493687076043 0.0118149973400486 0.97999687178823 5.58178677335184e-06 MirTarget -0.278748031939422 3.25318833392613e-05 NA NA NA hsa-miR-299-5p ITGB8 -0.162422032147768 0.435278723340297 0.97999687178823 5.58178677335184e-06 PITA -0.134230314791327 0.0406950714055293 NA NA NA hsa-miR-326 ITGB8 -0.552187708067123 0.039648668341622 0.97999687178823 5.58178677335184e-06 MirTarget;miRanda;miRNATAP -0.162289131974833 0.00113146147847366 NA NA NA hsa-miR-330-5p ITGB8 0.621676971901542 0.00233177378595631 0.97999687178823 5.58178677335184e-06 MirTarget;miRanda;miRNATAP -0.23015289010732 0.000420201425513396 NA NA NA hsa-miR-335-5p ITGB8 0.576542642348884 0.01886326850059 0.97999687178823 5.58178677335184e-06 miRNAWalker2_validate -0.137305181010439 0.0122819416935313 NA NA NA hsa-miR-33a-3p ITGB8 0.21453033253985 0.371591474252951 0.97999687178823 5.58178677335184e-06 MirTarget -0.233063288982323 6.09473256880357e-05 NA NA NA hsa-miR-340-3p ITGB8 0.130419461130918 0.46589192193662 0.97999687178823 5.58178677335184e-06 MirTarget -0.202741896196278 0.0077110361482489 NA NA NA hsa-miR-3653-3p ITGB8 0.832281812996978 0.0074838359407703 0.97999687178823 5.58178677335184e-06 MirTarget -0.141394027222242 0.00100289394746682 NA NA NA hsa-miR-590-3p ITGB8 0.858742926831233 0.000127281269371976 0.97999687178823 5.58178677335184e-06 MirTarget;PITA;miRanda -0.156436445540988 0.00853744752658385 NA NA NA hsa-miR-590-5p ITGB8 0.932604531809045 8.39043954167884e-05 0.97999687178823 5.58178677335184e-06 miRanda;miRNATAP -0.114019487256478 0.0427444328813147 NA NA NA hsa-miR-106b-5p JAK1 1.08518388423396 4.82746923373852e-09 0.00121091830967845 0.989818418655387 miRNAWalker2_validate;MirTarget -0.123175694510217 4.09386841350384e-05 NA NA NA hsa-miR-17-5p JAK1 1.57209612312313 5.10453838016207e-11 0.00121091830967845 0.989818418655387 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.107317911579793 2.61817718249796e-06 NA NA NA hsa-miR-30d-5p JAK1 0.26829866064717 0.0228954180095085 0.00121091830967845 0.989818418655387 MirTarget -0.121608596031009 0.0150545037140063 NA NA NA hsa-miR-193a-3p JAK2 0.148284355948959 0.379093889907371 -0.0494109993680087 0.797433753526829 miRanda -0.250512617427324 0.000347623598997713 NA NA NA hsa-miR-335-5p JAK2 0.576542642348884 0.01886326850059 -0.0494109993680087 0.797433753526829 miRNAWalker2_validate -0.177380307969431 0.000195423239156181 NA NA NA hsa-miR-337-3p JAK2 -0.228166532308969 0.303588587461454 -0.0494109993680087 0.797433753526829 PITA -0.247491026952353 2.3065514794653e-06 NA NA NA hsa-miR-495-3p JAK2 -0.024887553302567 0.897251687801771 -0.0494109993680087 0.797433753526829 mirMAP -0.153749391073343 0.0123506446587033 NA NA NA hsa-miR-30b-3p JAK3 0.252088263642787 0.216818735503048 0.944986889708332 8.57971873766924e-06 MirTarget -0.24816957830022 0.000128611578409111 NA NA NA hsa-miR-335-5p JAK3 0.576542642348884 0.01886326850059 0.944986889708332 8.57971873766924e-06 miRNAWalker2_validate -0.122272966074398 0.0234970845752365 NA NA NA hsa-let-7a-3p KIT 0.283468597868531 0.127007787220086 -2.18364564416018 1.34619666534478e-12 mirMAP -0.573232920740928 4.1393950007027e-08 NA NA NA hsa-let-7b-3p KIT 0.377956364821509 0.0061730103051373 -2.18364564416018 1.34619666534478e-12 mirMAP -0.734312219441494 2.30178280343678e-07 NA NA NA hsa-let-7f-1-3p KIT 1.09636075438131 3.42037366931931e-10 -2.18364564416018 1.34619666534478e-12 mirMAP -0.925027508686745 1.94203211526263e-19 NA NA NA hsa-miR-128-3p KIT 0.835320684237761 1.85756253116961e-09 -2.18364564416018 1.34619666534478e-12 MirTarget -1.07506542910453 4.17174459835382e-16 NA NA NA hsa-miR-130b-3p KIT 1.29757792612022 1.70655148591568e-06 -2.18364564416018 1.34619666534478e-12 miRNATAP -0.601918098232016 1.40392575280431e-19 NA NA NA hsa-miR-142-5p KIT 1.08445947321046 0.000126372881543671 -2.18364564416018 1.34619666534478e-12 PITA;miRNATAP -0.30122966632519 9.39589831464933e-06 NA NA NA hsa-miR-146b-5p KIT 2.23105707690238 3.83997814011313e-23 -2.18364564416018 1.34619666534478e-12 miRNAWalker2_validate -0.58166429719042 3.24898395259902e-14 NA NA NA hsa-miR-186-5p KIT 0.35512789129261 0.0196931838168008 -2.18364564416018 1.34619666534478e-12 miRNAWalker2_validate -0.78990871377223 4.86442901942526e-10 NA NA NA hsa-miR-193a-3p KIT 0.148284355948959 0.379093889907371 -2.18364564416018 1.34619666534478e-12 MirTarget;PITA;miRanda;miRNATAP -0.291738829198877 0.0136645942470456 NA NA NA hsa-miR-193b-3p KIT -0.0325435210716751 0.883410452152887 -2.18364564416018 1.34619666534478e-12 MirTarget;miRNATAP -0.494764860264332 1.36960561740566e-08 NA NA NA hsa-miR-19a-3p KIT 1.71062381299889 1.72281025366819e-11 -2.18364564416018 1.34619666534478e-12 miRTarBase;miRNATAP -0.675366548246002 7.1036771764437e-23 NA NA NA hsa-miR-19b-3p KIT 0.936987029203338 9.28141970787798e-06 -2.18364564416018 1.34619666534478e-12 miRNATAP -0.787777889957125 3.86313749226332e-20 NA NA NA hsa-miR-20a-5p KIT 1.57190995476158 8.72275528729458e-12 -2.18364564416018 1.34619666534478e-12 miRTarBase -0.748444403650498 4.71097996884466e-23 NA NA NA hsa-miR-221-3p KIT 1.11809809289021 6.56903442847056e-08 -2.18364564416018 1.34619666534478e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.783435333112653 2.28470416699421e-19 NA NA NA hsa-miR-222-3p KIT 1.50650995841483 1.51287294049382e-09 -2.18364564416018 1.34619666534478e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.695859405058022 5.68557353959702e-23 NA NA NA hsa-miR-301a-3p KIT 1.22580753116505 5.84016077664577e-09 -2.18364564416018 1.34619666534478e-12 miRNATAP -0.672882809079954 9.01348229498023e-15 NA NA NA hsa-miR-335-3p KIT 2.29463721765513 4.1956113745077e-18 -2.18364564416018 1.34619666534478e-12 mirMAP -0.624082843306586 2.75135700567594e-22 NA NA NA hsa-miR-335-5p KIT 0.576542642348884 0.01886326850059 -2.18364564416018 1.34619666534478e-12 miRNAWalker2_validate -0.414555397958293 1.49114882697918e-07 NA NA NA hsa-miR-34a-5p KIT 0.691825068787607 0.00069818668499891 -2.18364564416018 1.34619666534478e-12 MirTarget -0.556803231845088 2.74334429313197e-09 NA NA NA hsa-miR-421 KIT 1.26653675546617 2.35180826009926e-08 -2.18364564416018 1.34619666534478e-12 miRanda -0.600366022078717 2.45785125913891e-13 NA NA NA hsa-miR-429 KIT 1.58250682050303 4.75828087352234e-05 -2.18364564416018 1.34619666534478e-12 miRNATAP -0.313504846047207 1.56908330648263e-10 NA NA NA hsa-miR-450b-5p KIT 1.36137774989901 7.45499130609203e-11 -2.18364564416018 1.34619666534478e-12 MirTarget -0.402970788111126 7.60444424527717e-06 NA NA NA hsa-miR-454-3p KIT 0.823770738595667 1.30339728183332e-05 -2.18364564416018 1.34619666534478e-12 miRNATAP -0.655590039819375 5.2232721191952e-11 NA NA NA hsa-miR-501-5p KIT 1.59306197632625 2.04856600619363e-09 -2.18364564416018 1.34619666534478e-12 miRNATAP -0.512145372373153 1.51320058173931e-12 NA NA NA hsa-miR-505-3p KIT 0.68973424635459 0.00225185811813183 -2.18364564416018 1.34619666534478e-12 MirTarget;miRNATAP -0.545912965913216 8.52372511906566e-11 NA NA NA hsa-miR-577 KIT 0.615893340074725 0.210494450869356 -2.18364564416018 1.34619666534478e-12 mirMAP -0.220111140396044 2.74988884876312e-07 NA NA NA hsa-miR-590-3p KIT 0.858742926831233 0.000127281269371976 -2.18364564416018 1.34619666534478e-12 miRanda;mirMAP -0.639382145433773 1.5126097168825e-14 NA NA NA hsa-miR-671-5p KIT 1.6497630797889 2.89172004241043e-12 -2.18364564416018 1.34619666534478e-12 MirTarget -0.619436926164568 2.71643293704107e-16 NA NA NA hsa-miR-126-5p KITLG 0.450893496822779 0.0112966412858755 -0.0117905614264933 0.949011163097354 mirMAP -0.328988500026745 1.21641091223454e-07 NA NA NA hsa-miR-142-5p KITLG 1.08445947321046 0.000126372881543671 -0.0117905614264933 0.949011163097354 MirTarget;PITA -0.195366210976598 4.06534778023354e-07 NA NA NA hsa-miR-144-3p KITLG -1.37061426401952 5.85913017989725e-05 -0.0117905614264933 0.949011163097354 MirTarget -0.118729570246428 0.000297405033485964 NA NA NA hsa-miR-17-3p KITLG 1.37838995268509 5.00444740462873e-13 -0.0117905614264933 0.949011163097354 MirTarget -0.202876246667624 0.000310847248057728 NA NA NA hsa-miR-181b-5p KITLG 1.44365471425231 6.03807007335243e-15 -0.0117905614264933 0.949011163097354 MirTarget -0.135837951482917 0.019189872783768 NA NA NA hsa-miR-185-5p KITLG 1.20157041272762 3.03584066444936e-15 -0.0117905614264933 0.949011163097354 miRNAWalker2_validate -0.273652289153419 9.54562112535007e-05 NA NA NA hsa-miR-186-5p KITLG 0.35512789129261 0.0196931838168008 -0.0117905614264933 0.949011163097354 mirMAP -0.426077427050532 4.61046287145452e-09 NA NA NA hsa-miR-188-5p KITLG 1.57437249320621 2.78824007819973e-08 -0.0117905614264933 0.949011163097354 MirTarget -0.129360571339911 0.00141119745712733 NA NA NA hsa-miR-19a-3p KITLG 1.71062381299889 1.72281025366819e-11 -0.0117905614264933 0.949011163097354 mirMAP -0.203995023666302 1.08544086577525e-06 NA NA NA hsa-miR-19b-3p KITLG 0.936987029203338 9.28141970787798e-06 -0.0117905614264933 0.949011163097354 mirMAP -0.308871738801669 1.48297935187729e-09 NA NA NA hsa-miR-22-5p KITLG 0.668839167786886 0.00102248931590479 -0.0117905614264933 0.949011163097354 MirTarget -0.242810708772449 7.88300940802823e-06 NA NA NA hsa-miR-222-3p KITLG 1.50650995841483 1.51287294049382e-09 -0.0117905614264933 0.949011163097354 miRNAWalker2_validate -0.169278770221967 9.52054367857836e-05 NA NA NA hsa-miR-23a-3p KITLG 0.694558223570443 8.99413995422816e-10 -0.0117905614264933 0.949011163097354 mirMAP -0.372816480627272 0.000141960310611693 NA NA NA hsa-miR-26a-5p KITLG -0.507487084157331 3.23715933371269e-05 -0.0117905614264933 0.949011163097354 mirMAP -0.374947970371736 4.73097198651043e-05 NA NA NA hsa-miR-26b-5p KITLG -0.499493687076043 0.0118149973400486 -0.0117905614264933 0.949011163097354 mirMAP -0.333617954971169 1.48882030174496e-09 NA NA NA hsa-miR-299-5p KITLG -0.162422032147768 0.435278723340297 -0.0117905614264933 0.949011163097354 MirTarget;PITA -0.265668491025285 8.26490644407923e-07 NA NA NA hsa-miR-30b-5p KITLG -0.0106833209203501 0.954966272944722 -0.0117905614264933 0.949011163097354 mirMAP -0.27257818164748 4.03138290820375e-06 NA NA NA hsa-miR-30c-5p KITLG -0.172645077009891 0.276411433016536 -0.0117905614264933 0.949011163097354 mirMAP -0.173553481252026 0.0157447189518323 NA NA NA hsa-miR-30d-3p KITLG 0.0608340295673737 0.708110230223927 -0.0117905614264933 0.949011163097354 MirTarget -0.299015419996584 1.61044029834483e-05 NA NA NA hsa-miR-30d-5p KITLG 0.26829866064717 0.0228954180095085 -0.0117905614264933 0.949011163097354 mirMAP -0.199952301067917 0.0411763505074323 NA NA NA hsa-miR-30e-3p KITLG -0.444998679251398 0.000501880465265124 -0.0117905614264933 0.949011163097354 MirTarget -0.33203352791175 0.000172628661462121 NA NA NA hsa-miR-30e-5p KITLG -0.284839730810255 0.0405852891523165 -0.0117905614264933 0.949011163097354 mirMAP -0.354798950897089 1.231494025385e-05 NA NA NA hsa-miR-320a KITLG 0.451741078692272 0.00893327237386749 -0.0117905614264933 0.949011163097354 MirTarget;PITA;miRanda -0.175363934333499 0.00728709851459796 NA NA NA hsa-miR-320b KITLG 1.21733873788625 7.99882585998487e-07 -0.0117905614264933 0.949011163097354 MirTarget;PITA;miRanda -0.187033005093234 2.3554165788057e-05 NA NA NA hsa-miR-330-3p KITLG 0.391166748754241 0.0581284813543685 -0.0117905614264933 0.949011163097354 MirTarget -0.180339445888322 0.00136887368743425 NA NA NA hsa-miR-335-3p KITLG 2.29463721765513 4.1956113745077e-18 -0.0117905614264933 0.949011163097354 MirTarget -0.112165943681707 0.00472572037481932 NA NA NA hsa-miR-33a-3p KITLG 0.21453033253985 0.371591474252951 -0.0117905614264933 0.949011163097354 mirMAP -0.250267354828357 2.07010495286582e-07 NA NA NA hsa-miR-345-5p KITLG 0.906439112334506 0.00375888297100119 -0.0117905614264933 0.949011163097354 MirTarget -0.234444895898388 1.99634011463756e-11 NA NA NA hsa-miR-34a-5p KITLG 0.691825068787607 0.00069818668499891 -0.0117905614264933 0.949011163097354 MirTarget -0.184590215661966 0.000727877247631454 NA NA NA hsa-miR-374a-5p KITLG 0.239597788731458 0.0202963000797544 -0.0117905614264933 0.949011163097354 mirMAP -0.413785564643412 0.000220975306893477 NA NA NA hsa-miR-374b-5p KITLG 0.00249900187478502 0.985380083859555 -0.0117905614264933 0.949011163097354 mirMAP -0.333330342513761 6.47819165590156e-05 NA NA NA hsa-miR-450b-5p KITLG 1.36137774989901 7.45499130609203e-11 -0.0117905614264933 0.949011163097354 MirTarget;PITA;mirMAP -0.185069423076809 0.000344787915033345 NA NA NA hsa-miR-493-5p KITLG 1.32223598235404 3.01688809960418e-10 -0.0117905614264933 0.949011163097354 mirMAP -0.288751998950534 1.21313768148588e-08 NA NA NA hsa-miR-501-5p KITLG 1.59306197632625 2.04856600619363e-09 -0.0117905614264933 0.949011163097354 PITA;mirMAP -0.122245081945858 0.00442975817524132 NA NA NA hsa-miR-539-5p KITLG 0.455406484803261 0.10846447950775 -0.0117905614264933 0.949011163097354 mirMAP -0.141981479000052 0.000395834291679119 NA NA NA hsa-miR-577 KITLG 0.615893340074725 0.210494450869356 -0.0117905614264933 0.949011163097354 MirTarget;PITA -0.118992768392546 1.18580058382605e-06 NA NA NA hsa-miR-589-3p KITLG 1.00357906465313 8.20399071001461e-05 -0.0117905614264933 0.949011163097354 mirMAP -0.168442548201738 0.000231760035637477 NA NA NA hsa-miR-590-3p KITLG 0.858742926831233 0.000127281269371976 -0.0117905614264933 0.949011163097354 MirTarget;PITA;miRanda -0.280381811124215 7.95360490515113e-09 NA NA NA hsa-miR-664a-3p KITLG -0.0290482945770787 0.844010225386475 -0.0117905614264933 0.949011163097354 mirMAP -0.214501489153128 0.00558032225488025 NA NA NA hsa-miR-7-1-3p KITLG 0.94398354303717 7.5771319809992e-05 -0.0117905614264933 0.949011163097354 mirMAP -0.208775170601275 5.71185869584323e-06 NA NA NA hsa-miR-9-5p KITLG -0.887069929841985 0.00529865051479737 -0.0117905614264933 0.949011163097354 MirTarget -0.12736997449452 0.000260192598551989 NA NA NA hsa-miR-1-3p KRAS -2.73171785118192 3.4424534921136e-12 0.300368703208351 0.110791911795054 MirTarget -0.115915277384752 2.92146944379482e-05 NA NA NA hsa-miR-143-3p KRAS -0.941264957317006 7.19918948927784e-06 0.300368703208351 0.110791911795054 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.171991167842532 0.00145604806925598 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-195-3p KRAS -0.694544351365025 0.000214711021317786 0.300368703208351 0.110791911795054 mirMAP -0.125476194298183 0.0409442179699208 NA NA NA hsa-miR-27b-3p KRAS -0.439806942644624 0.000523870009254693 0.300368703208351 0.110791911795054 miRNATAP -0.234261645413416 0.010900000439838 NA NA NA hsa-miR-30a-3p KRAS -1.27950866170419 4.33230022379782e-09 0.300368703208351 0.110791911795054 MirTarget;miRNATAP -0.162483089033935 0.00153016636929067 NA NA NA hsa-miR-30e-3p KRAS -0.444998679251398 0.000501880465265124 0.300368703208351 0.110791911795054 MirTarget -0.245926388627632 0.00695814757879246 NA NA NA hsa-miR-337-3p KRAS -0.228166532308969 0.303588587461454 0.300368703208351 0.110791911795054 PITA;miRNATAP -0.123928824418327 0.0175639423373004 NA NA NA hsa-miR-146b-5p LAMA2 2.23105707690238 3.83997814011313e-23 -0.817286054002912 0.00263248830630044 miRanda -0.297529914934852 1.01900713127117e-05 NA NA NA hsa-miR-590-3p LAMA2 0.858742926831233 0.000127281269371976 -0.817286054002912 0.00263248830630044 miRanda -0.570660077753301 4.16134103546516e-16 NA NA NA hsa-miR-188-5p LAMA4 1.57437249320621 2.78824007819973e-08 0.109863670029437 0.552070038635586 miRNATAP -0.238907274851065 1.6609786958503e-09 NA NA NA hsa-miR-21-5p LAMA4 2.21515015440792 6.0468197386674e-49 0.109863670029437 0.552070038635586 MirTarget -0.179609460137434 0.00406941782343354 NA NA NA hsa-miR-2355-3p LAMA4 0.101789577163865 0.693158423682028 0.109863670029437 0.552070038635586 MirTarget -0.140932909290969 0.00198766798538631 NA NA NA hsa-miR-338-3p LAMA4 -0.0138760121093551 0.956163634155272 0.109863670029437 0.552070038635586 miRanda -0.122494824714259 0.00618916829956273 NA NA NA hsa-miR-429 LAMA4 1.58250682050303 4.75828087352234e-05 0.109863670029437 0.552070038635586 miRanda -0.272421141945111 5.72270595972534e-25 NA NA NA hsa-miR-590-3p LAMA4 0.858742926831233 0.000127281269371976 0.109863670029437 0.552070038635586 miRanda -0.466164157317079 1.81837513600306e-24 NA NA NA hsa-miR-590-5p LAMA4 0.932604531809045 8.39043954167884e-05 0.109863670029437 0.552070038635586 MirTarget;miRanda -0.371450996232063 6.34775355526592e-17 NA NA NA hsa-miR-93-3p LAMA4 1.18510939268904 1.19856269043125e-06 0.109863670029437 0.552070038635586 miRNAWalker2_validate -0.341473682275073 2.03049571923723e-15 NA NA NA hsa-let-7a-3p LAMB1 0.283468597868531 0.127007787220086 0.781376511163481 3.99206690301919e-08 MirTarget -0.208436257195007 1.27735157876701e-05 NA NA NA hsa-miR-16-5p LAMB1 0.468459442059375 0.02635007201346 0.781376511163481 3.99206690301919e-08 miRNAWalker2_validate -0.153100626455691 0.000273029400359765 NA NA NA hsa-miR-29b-1-5p LAMB2 1.27585983480192 1.70509960024426e-05 -0.194400502822468 0.207702071712579 MirTarget -0.166772629150007 5.86670658229593e-08 NA NA NA hsa-miR-484 LAMB2 0.401753773460753 0.0490851523101605 -0.194400502822468 0.207702071712579 miRNAWalker2_validate -0.277462407610313 6.50630519576998e-10 NA NA NA hsa-miR-218-5p LAMB3 -0.615157868107884 0.00447149109697709 1.34334657091502 1.75876946460733e-06 miRNAWalker2_validate;miRTarBase -0.413764116434437 1.81938472412508e-07 25337271;20163849;23320911;23159910;17998940 The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma ESCC;Polymorphisms involved in the miR 218 LAMB3 pathway and susceptibility of cervical cancer a case control study in Chinese women; MicroRNA-218 miR-218 can target laminin-5 beta3 LAMB3 but suppressed by HPV-16 E6 protein;However this association was not observed for the miR-218 binding site SNP rs2566 on LAMB3;Furthermore we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that LAMB3 was directly regulated by miR-218;We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218; We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218 worse prognosis;;;; esophageal cancer;cervical and endocervical cancer;cervical and endocervical cancer;head and neck cancer;cervical and endocervical cancer hsa-miR-107 LAMC1 0.85152957824299 1.22369651446858e-11 0.370285667657678 0.0366283240859651 miRanda -0.301124576057999 0.000348957719891837 NA NA NA hsa-miR-126-5p LAMC1 0.450893496822779 0.0112966412858755 0.370285667657678 0.0366283240859651 mirMAP -0.204423638001076 0.000795330168099449 NA NA NA hsa-miR-140-5p LAMC1 0.132398579631585 0.457960134430787 0.370285667657678 0.0366283240859651 MirTarget;PITA;miRanda;miRNATAP -0.261592794262214 1.64672141876271e-05 NA NA NA hsa-miR-146b-5p LAMC1 2.23105707690238 3.83997814011313e-23 0.370285667657678 0.0366283240859651 miRanda -0.18146276886274 3.4354268406317e-05 NA NA NA hsa-miR-15a-5p LAMC1 1.07800995489566 4.32072598796529e-10 0.370285667657678 0.0366283240859651 MirTarget -0.36380416437207 9.57010535911872e-10 NA NA NA hsa-miR-15b-5p LAMC1 0.637819606405168 0.000580041575431604 0.370285667657678 0.0366283240859651 MirTarget -0.289362154844077 4.5730258025572e-07 NA NA NA hsa-miR-16-5p LAMC1 0.468459442059375 0.02635007201346 0.370285667657678 0.0366283240859651 miRNAWalker2_validate;MirTarget -0.34568030515619 2.92954987151097e-12 NA NA NA hsa-miR-182-5p LAMC1 1.73826081735237 5.69817940588551e-09 0.370285667657678 0.0366283240859651 miRNATAP -0.24769080487935 2.10491951902756e-13 NA NA NA hsa-miR-186-5p LAMC1 0.35512789129261 0.0196931838168008 0.370285667657678 0.0366283240859651 mirMAP -0.337679821870404 1.91677646135264e-06 NA NA NA hsa-miR-188-5p LAMC1 1.57437249320621 2.78824007819973e-08 0.370285667657678 0.0366283240859651 MirTarget -0.13858753675395 0.000380800640543809 NA NA NA hsa-miR-193a-3p LAMC1 0.148284355948959 0.379093889907371 0.370285667657678 0.0366283240859651 MirTarget;PITA;miRanda -0.136933286540383 0.0357552949392845 NA NA NA hsa-miR-193b-3p LAMC1 -0.0325435210716751 0.883410452152887 0.370285667657678 0.0366283240859651 MirTarget -0.103365009076654 0.0357911842856895 NA NA NA hsa-miR-200b-3p LAMC1 2.06025765178663 3.07718049337497e-10 0.370285667657678 0.0366283240859651 MirTarget;TargetScan -0.246259940243578 3.71481628992343e-16 NA NA NA hsa-miR-200c-3p LAMC1 1.74925752003763 3.42000026705311e-08 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.249688858971602 2.7176899946246e-15 NA NA NA hsa-miR-29a-3p LAMC1 -0.235052170104117 0.138527567930958 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.540972878789512 1.21184059816068e-16 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 0.0225365195743876 0.914313337784307 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.460253233577372 1.33176960026411e-21 NA NA NA hsa-miR-29c-3p LAMC1 -1.34143813218298 2.77493790306384e-12 0.370285667657678 0.0366283240859651 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.255427761607858 1.89773257657361e-06 NA NA NA hsa-miR-320b LAMC1 1.21733873788625 7.99882585998487e-07 0.370285667657678 0.0366283240859651 miRanda -0.139586224790244 0.00116125404115432 NA NA NA hsa-miR-338-3p LAMC1 -0.0138760121093551 0.956163634155272 0.370285667657678 0.0366283240859651 MirTarget;miRanda -0.18677672559407 1.15906946136847e-05 NA NA NA hsa-miR-33a-3p LAMC1 0.21453033253985 0.371591474252951 0.370285667657678 0.0366283240859651 mirMAP -0.246784623754038 1.07319006353007e-07 NA NA NA hsa-miR-362-3p LAMC1 0.994614346444282 4.39793878186399e-05 0.370285667657678 0.0366283240859651 miRanda -0.262897903033329 3.0087687360792e-09 NA NA NA hsa-miR-374a-5p LAMC1 0.239597788731458 0.0202963000797544 0.370285667657678 0.0366283240859651 mirMAP -0.253019751086461 0.020186846195087 NA NA NA hsa-miR-374b-5p LAMC1 0.00249900187478502 0.985380083859555 0.370285667657678 0.0366283240859651 mirMAP -0.178251790110345 0.0284586917735997 NA NA NA hsa-miR-424-5p LAMC1 0.956135912596328 0.00035164943928494 0.370285667657678 0.0366283240859651 MirTarget;miRNATAP -0.147493817928623 0.000217586840492112 NA NA NA hsa-miR-429 LAMC1 1.58250682050303 4.75828087352234e-05 0.370285667657678 0.0366283240859651 MirTarget;PITA;miRanda;miRNATAP -0.209839361894973 1.99209293409558e-15 NA NA NA hsa-miR-577 LAMC1 0.615893340074725 0.210494450869356 0.370285667657678 0.0366283240859651 PITA -0.11681997382697 7.52013668940607e-07 NA NA NA hsa-miR-590-3p LAMC1 0.858742926831233 0.000127281269371976 0.370285667657678 0.0366283240859651 PITA;miRanda;mirMAP -0.353952907766387 1.01875179161225e-14 NA NA NA hsa-miR-7-1-3p LAMC1 0.94398354303717 7.5771319809992e-05 0.370285667657678 0.0366283240859651 mirMAP -0.28536547268048 5.2424722666758e-11 NA NA NA hsa-miR-92a-3p LAMC1 1.06124545165614 6.51550014372282e-08 0.370285667657678 0.0366283240859651 miRNAWalker2_validate -0.220119230160509 4.06172849280034e-05 NA NA NA hsa-miR-942-5p LAMC1 0.971074085161366 9.47503417656145e-05 0.370285667657678 0.0366283240859651 MirTarget -0.322548188660511 3.40563100526069e-15 NA NA NA hsa-miR-96-5p LAMC1 1.44821155854693 6.56312590328933e-06 0.370285667657678 0.0366283240859651 MirTarget;TargetScan;miRNATAP -0.223185392616619 6.61668212778562e-11 NA NA NA hsa-miR-98-5p LAMC1 0.72508924193932 6.07191196761022e-10 0.370285667657678 0.0366283240859651 miRNAWalker2_validate -0.188480153680342 0.0407044980467923 NA NA NA hsa-let-7b-3p LPAR1 0.377956364821509 0.0061730103051373 -1.56606812793793 2.0874874683954e-10 mirMAP -0.415688711000319 0.000263732901988947 NA NA NA hsa-let-7f-1-3p LPAR1 1.09636075438131 3.42037366931931e-10 -1.56606812793793 2.0874874683954e-10 mirMAP -0.661277846036416 1.17825042823496e-15 NA NA NA hsa-miR-1287-5p LPAR1 0.31955201327358 0.0331771744240274 -1.56606812793793 2.0874874683954e-10 MirTarget -0.242801220595803 0.0213855452820067 NA NA NA hsa-miR-16-2-3p LPAR1 0.869267463341732 0.000785361809327569 -1.56606812793793 2.0874874683954e-10 MirTarget;mirMAP -0.386415969674934 2.24468270254492e-11 NA NA NA hsa-miR-188-5p LPAR1 1.57437249320621 2.78824007819973e-08 -1.56606812793793 2.0874874683954e-10 MirTarget -0.363056646010589 2.77195341765589e-11 NA NA NA hsa-miR-200b-3p LPAR1 2.06025765178663 3.07718049337497e-10 -1.56606812793793 2.0874874683954e-10 MirTarget;TargetScan -0.352326937227282 6.08851543911358e-16 NA NA NA hsa-miR-200c-3p LPAR1 1.74925752003763 3.42000026705311e-08 -1.56606812793793 2.0874874683954e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.389495411022243 4.74204301116216e-18 NA NA NA hsa-miR-20a-3p LPAR1 0.703027135708586 0.022464856696655 -1.56606812793793 2.0874874683954e-10 MirTarget -0.291723735988118 1.03703288983793e-08 NA NA NA hsa-miR-23a-3p LPAR1 0.694558223570443 8.99413995422816e-10 -1.56606812793793 2.0874874683954e-10 MirTarget;miRNATAP -0.726730407854542 6.19532663134882e-08 NA NA NA hsa-miR-324-5p LPAR1 0.800946351685734 0.00101337664367375 -1.56606812793793 2.0874874683954e-10 miRanda -0.372394550641193 1.83032180503224e-09 NA NA NA hsa-miR-335-3p LPAR1 2.29463721765513 4.1956113745077e-18 -1.56606812793793 2.0874874683954e-10 mirMAP -0.453010512699217 2.09486958109304e-18 NA NA NA hsa-miR-339-5p LPAR1 0.51232205151031 0.0560469213103598 -1.56606812793793 2.0874874683954e-10 miRanda -0.238524404156571 3.47062505819517e-05 NA NA NA hsa-miR-361-5p LPAR1 0.538048008019709 1.61165802415302e-07 -1.56606812793793 2.0874874683954e-10 miRanda -0.890079016157184 2.99077887076312e-09 NA NA NA hsa-miR-421 LPAR1 1.26653675546617 2.35180826009926e-08 -1.56606812793793 2.0874874683954e-10 miRanda -0.425656439383584 9.20899947288877e-11 NA NA NA hsa-miR-429 LPAR1 1.58250682050303 4.75828087352234e-05 -1.56606812793793 2.0874874683954e-10 MirTarget;miRanda;miRNATAP -0.271242259352833 1.90927980965871e-12 NA NA NA hsa-miR-501-5p LPAR1 1.59306197632625 2.04856600619363e-09 -1.56606812793793 2.0874874683954e-10 MirTarget;miRNATAP -0.407341017595034 1.23958139756049e-12 NA NA NA hsa-miR-576-5p LPAR1 0.872721964495849 5.20470410008775e-05 -1.56606812793793 2.0874874683954e-10 mirMAP -0.496778344177355 4.90106136500549e-13 NA NA NA hsa-miR-671-5p LPAR1 1.6497630797889 2.89172004241043e-12 -1.56606812793793 2.0874874683954e-10 MirTarget -0.399505020059778 7.42054166381694e-11 NA NA NA hsa-miR-7-1-3p LPAR1 0.94398354303717 7.5771319809992e-05 -1.56606812793793 2.0874874683954e-10 MirTarget -0.443088227382644 1.0174239149075e-12 NA NA NA hsa-miR-874-3p LPAR1 0.24291801110313 0.253403155001571 -1.56606812793793 2.0874874683954e-10 MirTarget -0.202846966558331 0.00593795883630256 NA NA NA hsa-miR-143-3p LPAR2 -0.941264957317006 7.19918948927784e-06 0.779982233967791 2.51719039118573e-05 miRNATAP -0.317759048697017 1.4712694737069e-09 NA NA NA hsa-miR-106b-5p LPAR3 1.08518388423396 4.82746923373852e-09 -2.42785662189318 2.89235623996199e-08 mirMAP -0.605011690537668 2.48322554285072e-05 NA NA NA hsa-miR-141-3p LPAR3 1.76274853293464 9.99331900755725e-07 -2.42785662189318 2.89235623996199e-08 MirTarget;TargetScan -0.233489058452887 0.00170023610546129 NA NA NA hsa-miR-200a-3p LPAR3 2.02394729844446 2.21240501925011e-08 -2.42785662189318 2.89235623996199e-08 MirTarget -0.25535257436036 0.000508112895999835 NA NA NA hsa-miR-24-3p LPAR3 0.425646348491286 0.00136678638934554 -2.42785662189318 2.89235623996199e-08 miRNATAP -0.592458177379063 0.00462924390688235 NA NA NA hsa-miR-590-3p LPAR3 0.858742926831233 0.000127281269371976 -2.42785662189318 2.89235623996199e-08 miRanda -0.40001291855017 0.000989969398673567 NA NA NA hsa-miR-10a-3p LPAR4 0.673742947104233 0.000577781470262632 0.253887996571817 0.360126186136074 MirTarget -0.197392505606272 0.0251927638472216 NA NA NA hsa-miR-149-5p LPAR4 -0.814305489055795 0.00575972754574164 0.253887996571817 0.360126186136074 miRNATAP -0.14989096970544 0.00868856506222068 NA NA NA hsa-miR-192-5p LPAR4 2.0867723747501 3.57854249239079e-08 0.253887996571817 0.360126186136074 MirTarget;miRNATAP -0.357292664266111 1.77337975673895e-18 NA NA NA hsa-miR-215-5p LPAR4 1.10296552366805 0.0225256935718223 0.253887996571817 0.360126186136074 MirTarget -0.211924467078938 3.45742372069714e-10 NA NA NA hsa-miR-222-5p LPAR4 1.40730191326147 1.77506391601374e-06 0.253887996571817 0.360126186136074 MirTarget -0.446395056557783 1.55484224346962e-16 NA NA NA hsa-miR-33a-3p LPAR4 0.21453033253985 0.371591474252951 0.253887996571817 0.360126186136074 MirTarget -0.576203436141961 1.7955892877634e-16 NA NA NA hsa-miR-342-3p LPAR4 0.235422340773149 0.290471946350276 0.253887996571817 0.360126186136074 miRanda -0.297948011288765 8.45169859577272e-05 NA NA NA hsa-miR-3613-5p LPAR4 1.03938524872813 2.63575941507995e-05 0.253887996571817 0.360126186136074 miRNATAP -0.509531847188272 2.37793007927671e-15 NA NA NA hsa-miR-375 LPAR4 -0.348733074320394 0.47719066431766 0.253887996571817 0.360126186136074 miRanda -0.165329956891948 1.08297568286695e-06 NA NA NA hsa-miR-429 LPAR4 1.58250682050303 4.75828087352234e-05 0.253887996571817 0.360126186136074 miRNATAP -0.398594548142088 1.92506842535883e-23 NA NA NA hsa-miR-590-3p LPAR4 0.858742926831233 0.000127281269371976 0.253887996571817 0.360126186136074 MirTarget;miRanda;mirMAP -0.664019635589332 1.21285560076234e-21 NA NA NA hsa-miR-7-1-3p LPAR4 0.94398354303717 7.5771319809992e-05 0.253887996571817 0.360126186136074 mirMAP -0.618383828831428 2.04628603083053e-21 NA NA NA hsa-miR-365a-3p LPAR5 -0.801671336684825 1.28258342849568e-06 -0.118356978757014 0.565799523687181 MirTarget -0.173796217132974 0.0210608265493323 NA NA NA hsa-miR-101-3p MAP2K1 -0.0683272309939689 0.544163124741916 0.111982868739943 0.187998698050308 miRNAWalker2_validate -0.117828996301904 0.0127213319339809 NA NA NA hsa-miR-30c-5p MAP2K1 -0.172645077009891 0.276411433016536 0.111982868739943 0.187998698050308 miRNAWalker2_validate -0.100318272256955 0.00225430781068853 NA NA NA hsa-miR-497-5p MAP2K1 -0.486115215577409 0.00973897247186318 0.111982868739943 0.187998698050308 miRNAWalker2_validate -0.180587908064585 8.99853144758222e-12 NA NA NA hsa-let-7b-5p MAP2K2 0.16896311055967 0.160596228583843 -0.498273142878376 4.11434955612368e-07 miRNAWalker2_validate -0.122013557820935 0.0194035208998624 NA NA NA hsa-miR-130a-3p MAPK1 0.218018009582956 0.274232880676821 -0.0171538275729688 0.814645329854297 mirMAP -0.106285308290665 1.23019380786751e-06 NA NA NA hsa-miR-140-5p MAPK1 0.132398579631585 0.457960134430787 -0.0171538275729688 0.814645329854297 miRanda -0.112433461307928 5.05044102808941e-06 NA NA NA hsa-miR-195-5p MAPK1 -1.07154705036962 4.16544134775761e-08 -0.0171538275729688 0.814645329854297 mirMAP -0.103164505308584 2.20049902079219e-06 NA NA NA hsa-miR-29a-3p MAPK1 -0.235052170104117 0.138527567930958 -0.0171538275729688 0.814645329854297 mirMAP -0.104338880637724 0.000188764730222907 NA NA NA hsa-miR-30e-5p MAPK1 -0.284839730810255 0.0405852891523165 -0.0171538275729688 0.814645329854297 mirMAP -0.10691321934173 0.000861114694387204 NA NA NA hsa-miR-542-3p MAPK3 1.12416854979951 1.02649534578738e-12 -0.994575991624869 1.37956923161954e-12 miRanda -0.133717139470687 0.0149379146524607 NA NA NA hsa-miR-140-5p MDM2 0.132398579631585 0.457960134430787 0.684922426263625 2.25604330928728e-05 miRanda -0.118928275348611 0.0363891795263222 NA NA NA hsa-miR-143-3p MDM2 -0.941264957317006 7.19918948927784e-06 0.684922426263625 2.25604330928728e-05 miRNAWalker2_validate -0.180383156186656 0.000115815216754902 NA NA NA hsa-miR-145-5p MDM2 -1.54503595327403 2.65080161523141e-09 0.684922426263625 2.25604330928728e-05 miRNAWalker2_validate -0.198874217191523 5.71192946278001e-08 NA NA NA hsa-miR-181a-2-3p MDM2 0.761758815767271 3.4163207928657e-06 0.684922426263625 2.25604330928728e-05 mirMAP -0.12351540646709 0.0420557321490906 NA NA NA hsa-miR-23b-3p MDM2 -0.228571473429 0.0553601132069074 0.684922426263625 2.25604330928728e-05 mirMAP -0.19056537785509 0.0271564148046807 NA NA NA hsa-miR-26b-5p MDM2 -0.499493687076043 0.0118149973400486 0.684922426263625 2.25604330928728e-05 miRNAWalker2_validate -0.109564644928444 0.0305745771657186 NA NA NA hsa-miR-374b-5p MDM2 0.00249900187478502 0.985380083859555 0.684922426263625 2.25604330928728e-05 mirMAP -0.269149244343905 0.000306005928313723 NA NA NA hsa-miR-1-3p MET -2.73171785118192 3.4424534921136e-12 1.57615611374924 2.64556490930012e-12 miRTarBase -0.154629845683453 7.76035855439818e-06 26499783;27169691 Moreover both EGCG and miR-1 mimic inhibited c-MET expression and combination treatment with EGCG and c-MET inhibitor crizotinib had enhanced inhibitory effects on the growth of MG-63 and U-2OS cells;Dual receptor EGFR and c MET inhibition by tumor suppressive miR 1 and miR 206 in head and neck squamous cell carcinoma ; sarcoma;head and neck cancer hsa-miR-139-5p MET -1.41674256628297 4.51005988644234e-14 1.57615611374924 2.64556490930012e-12 miRanda -0.410042564110109 9.90376215787969e-09 NA NA NA hsa-miR-23b-3p MET -0.228571473429 0.0553601132069074 1.57615611374924 2.64556490930012e-12 miRNAWalker2_validate;miRTarBase -0.475159770472343 0.000108232355285154 19490101 MicroRNA 23b mediates urokinase and c met downmodulation and a decreased migration of human hepatocellular carcinoma cells; In the present study to understand whether the expression of these genes might be coregulated by specific microRNAs miRs in human cells we predicted that Homo sapiens microRNA-23b could recognize two sites in the 3'-UTR of uPA and four sites in the c-met 3'-UTR by the algorithm pictar; The evidence obtained shows that overexpression of miR-23b leads to uPA and c-met downregulation and to decreased migration and proliferation abilities of HCC cells liver cancer hsa-miR-30a-3p MET -1.27950866170419 4.33230022379782e-09 1.57615611374924 2.64556490930012e-12 mirMAP -0.220851472546187 0.00055542271791313 NA NA NA hsa-miR-30a-5p MET -0.742755040631906 3.79943871404435e-05 1.57615611374924 2.64556490930012e-12 miRNAWalker2_validate -0.226699840816623 0.00421090688220656 NA NA NA hsa-miR-30e-3p MET -0.444998679251398 0.000501880465265124 1.57615611374924 2.64556490930012e-12 mirMAP -0.35559755275231 0.00174885883208659 NA NA NA hsa-miR-664a-3p MET -0.0290482945770787 0.844010225386475 1.57615611374924 2.64556490930012e-12 mirMAP -0.22287327528127 0.0248272059740308 NA NA NA hsa-miR-17-3p MTCP1 1.37838995268509 5.00444740462873e-13 -0.524070656796974 2.67500452340774e-07 MirTarget -0.129796202743062 4.00702721492447e-05 NA NA NA hsa-miR-101-3p MTOR -0.0683272309939689 0.544163124741916 0.21940805926093 0.0271926749829329 miRNATAP -0.144390467987404 0.00929849630008951 25480586;20805506 Meanwhile bioinformatic analysis demonstrated that mTOR gene was a direct target of miR-101; Overexpression of miR-101 significantly decreased the expression of mTOR at both mRNA and protein levels in Saos-2 cells consequently inhibiting Saos-2 cells proliferation and promoting cells apoptosis in an mTOR-dependent manner; mTOR plays an important role in mediating miR-101 dependent biological functions in osteosarcoma; Reintroduction of miR-101 may be a novel therapeutic strategy by down-regulating mTOR expression;Furthermore inhibition of mTOR which is targeted by miR-101 led to reduced tumor growth in engrafted ALCL mouse models ; sarcoma;lymphoma hsa-miR-139-5p MYB -1.41674256628297 4.51005988644234e-14 2.23123493373074 1.58587972966078e-12 miRanda -0.695700728223086 1.95374040501245e-12 NA NA NA hsa-miR-195-5p MYB -1.07154705036962 4.16544134775761e-08 2.23123493373074 1.58587972966078e-12 miRNATAP -0.488705425718211 9.31281513701649e-07 24486218;26622903 MicroRNA 195 inhibits non small cell lung cancer cell proliferation migration and invasion by targeting MYB; Using miRNA target prediction algorithms and reporter assays we demonstrated that miR-195 suppressed the expression of MYB both at the mRNA and protein level and was directly bound to the 3'untranslated region of MYB mRNA; Overexpression of MYB in NSCLC cells using an ectopic expression vector restored the decreased cell proliferation migration and invasion effects induced by miR-195; Finally we observed an inverse correlation between MYB and miR-195 in NSCLC;microRNA 195 inhibits the proliferation migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression; Moreover miR-195 repressed the expression of CCND2 and MYB in the HeLa cells at the mRNA and protein levels ; lung squamous cell cancer;cervical and endocervical cancer hsa-miR-28-5p MYB -0.22318016376076 0.0194144033008573 2.23123493373074 1.58587972966078e-12 miRanda -1.01499047445268 3.10218661903081e-06 NA NA NA hsa-miR-497-5p MYB -0.486115215577409 0.00973897247186318 2.23123493373074 1.58587972966078e-12 miRNATAP -0.330120492144168 0.00211192257157167 NA NA NA hsa-let-7c-5p MYC -0.148489254129201 0.548077841857242 -0.025616667114428 0.889168572840311 miRNAWalker2_validate;miRTarBase -0.117429030238432 0.00982219946674066 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-26a-5p MYC -0.507487084157331 3.23715933371269e-05 -0.025616667114428 0.889168572840311 miRNAWalker2_validate -0.282916794526639 0.00222606342624675 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-34c-5p MYC 1.37406314990472 2.42956736488761e-09 -0.025616667114428 0.889168572840311 miRNAWalker2_validate;miRTarBase;miRanda -0.161936986237348 0.000782914009115942 NA NA NA hsa-let-7d-5p NGF 0.686819803681087 1.08347860862215e-06 -0.462088517867856 0.166953331832769 MirTarget -0.620237987554177 1.4471375958169e-05 NA NA NA hsa-let-7g-5p NGF 0.296128761926282 0.0296823495976068 -0.462088517867856 0.166953331832769 MirTarget -0.784396596061535 1.60720097358693e-07 NA NA NA hsa-miR-320b NGF 1.21733873788625 7.99882585998487e-07 -0.462088517867856 0.166953331832769 miRanda -0.232408820981967 0.00421569867846829 NA NA NA hsa-miR-423-5p NGF 0.554579912507932 7.65114789083517e-05 -0.462088517867856 0.166953331832769 MirTarget;miRNATAP -0.416546543170073 0.00441284912185688 NA NA NA hsa-miR-429 NGF 1.58250682050303 4.75828087352234e-05 -0.462088517867856 0.166953331832769 miRanda -0.35062173952661 3.8824604215482e-12 NA NA NA hsa-miR-98-5p NGF 0.72508924193932 6.07191196761022e-10 -0.462088517867856 0.166953331832769 MirTarget -0.492108805714805 0.00445439770179829 NA NA NA hsa-miR-148b-5p NGFR 0.7888996589349 0.00420956802908159 -1.27138411947154 0.0105838619689849 mirMAP -0.783886879144266 7.0199979787786e-12 NA NA NA hsa-miR-15b-3p NGFR 0.811179945491507 0.000927520880593552 -1.27138411947154 0.0105838619689849 mirMAP -1.00803469415471 4.53917707110821e-18 NA NA NA hsa-miR-185-3p NGFR 1.38509197368746 3.93425296894499e-10 -1.27138411947154 0.0105838619689849 miRNATAP -0.89026005138782 2.65944773442419e-11 NA NA NA hsa-miR-194-3p NGFR 1.91477879150304 2.49480074178753e-07 -1.27138411947154 0.0105838619689849 mirMAP -0.654014312831681 5.49063098897127e-17 NA NA NA hsa-miR-2110 NGFR 0.359318473683641 0.126104910543249 -1.27138411947154 0.0105838619689849 mirMAP -0.56830825707543 3.29003502758578e-05 NA NA NA hsa-miR-27a-3p NGFR 0.523219911315699 0.000116410279757859 -1.27138411947154 0.0105838619689849 miRNATAP -1.12321660749445 4.56571385929703e-07 NA NA NA hsa-miR-30b-3p NGFR 0.252088263642787 0.216818735503048 -1.27138411947154 0.0105838619689849 mirMAP -0.896495285363743 1.06486404245523e-09 NA NA NA hsa-miR-324-5p NGFR 0.800946351685734 0.00101337664367375 -1.27138411947154 0.0105838619689849 miRanda -0.723051647048802 2.51021031023907e-09 NA NA NA hsa-miR-326 NGFR -0.552187708067123 0.039648668341622 -1.27138411947154 0.0105838619689849 miRanda;mirMAP -0.331531760974572 0.00356453541964204 NA NA NA hsa-miR-330-5p NGFR 0.621676971901542 0.00233177378595631 -1.27138411947154 0.0105838619689849 miRanda;mirMAP;miRNATAP -0.825777109281573 1.51725024361367e-08 NA NA NA hsa-miR-335-5p NGFR 0.576542642348884 0.01886326850059 -1.27138411947154 0.0105838619689849 miRNAWalker2_validate -0.27779121019162 0.0263191417974367 NA NA NA hsa-miR-34a-5p NGFR 0.691825068787607 0.00069818668499891 -1.27138411947154 0.0105838619689849 mirMAP -0.94250404145591 6.4524551487515e-11 NA NA NA hsa-miR-361-3p NGFR 0.485361250955594 0.00074097948047418 -1.27138411947154 0.0105838619689849 mirMAP -1.06893717781091 3.6859647171546e-07 NA NA NA hsa-miR-3614-5p NGFR 0.288051497709626 0.339707047011435 -1.27138411947154 0.0105838619689849 mirMAP -0.624813895628441 1.32182670117345e-08 NA NA NA hsa-miR-429 NGFR 1.58250682050303 4.75828087352234e-05 -1.27138411947154 0.0105838619689849 miRNATAP -0.597702325081935 9.19482419041797e-16 NA NA NA hsa-miR-625-5p NGFR 0.748754910408313 0.00783938428700196 -1.27138411947154 0.0105838619689849 mirMAP -0.883652274781087 1.04408897114421e-17 NA NA NA hsa-miR-502-5p NOS3 0.873538712251823 0.0012275719769761 0.847598744739426 1.98951254077361e-07 MirTarget -0.105875872662032 0.015490989990724 NA NA NA hsa-miR-324-5p NR4A1 0.800946351685734 0.00101337664367375 -0.900239576480896 0.000813051293070034 miRanda -0.146216994447418 0.0309209717422171 NA NA NA hsa-miR-362-3p NR4A1 0.994614346444282 4.39793878186399e-05 -0.900239576480896 0.000813051293070034 miRanda -0.187097921683704 0.00717382685827689 NA NA NA hsa-miR-93-5p NR4A1 1.68243825551104 4.62947431501061e-15 -0.900239576480896 0.000813051293070034 miRNAWalker2_validate -0.236560594154979 0.00121893352119154 NA NA NA hsa-let-7c-5p NRAS -0.148489254129201 0.548077841857242 0.472115197068407 1.46412306069986e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.116156287548294 1.72253473969425e-05 NA NA NA hsa-miR-145-5p NRAS -1.54503595327403 2.65080161523141e-09 0.472115197068407 1.46412306069986e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.178102234288129 1.35397717970295e-13 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-195-3p NRAS -0.694544351365025 0.000214711021317786 0.472115197068407 1.46412306069986e-05 mirMAP -0.178001439808627 4.22616332760488e-07 NA NA NA hsa-miR-27b-3p NRAS -0.439806942644624 0.000523870009254693 0.472115197068407 1.46412306069986e-05 miRNATAP -0.122626934598437 0.0228784339281055 NA NA NA hsa-miR-28-5p NRAS -0.22318016376076 0.0194144033008573 0.472115197068407 1.46412306069986e-05 MirTarget;PITA;miRanda;miRNATAP -0.364769200749754 4.56799990803318e-07 NA NA NA hsa-miR-30a-3p NRAS -1.27950866170419 4.33230022379782e-09 0.472115197068407 1.46412306069986e-05 mirMAP -0.162026403698143 3.66712901569314e-08 NA NA NA hsa-miR-142-3p NTF3 1.80134804047727 3.87649742898476e-07 -1.52188285755702 4.13580352197116e-07 miRanda -0.224496362207444 1.10723301360039e-05 NA NA NA hsa-miR-200b-3p NTF3 2.06025765178663 3.07718049337497e-10 -1.52188285755702 4.13580352197116e-07 TargetScan -0.168627433095034 0.00227099339738329 NA NA NA hsa-miR-200c-3p NTF3 1.74925752003763 3.42000026705311e-08 -1.52188285755702 4.13580352197116e-07 miRNAWalker2_validate;miRNATAP -0.156401895071453 0.00666576100228823 NA NA NA hsa-miR-21-5p NTF3 2.21515015440792 6.0468197386674e-49 -1.52188285755702 4.13580352197116e-07 miRTarBase;miRNATAP -0.741062168553893 1.15482809906199e-13 NA NA NA hsa-miR-221-3p NTF3 1.11809809289021 6.56903442847056e-08 -1.52188285755702 4.13580352197116e-07 miRNATAP -0.473339106207777 5.45189358552792e-08 NA NA NA hsa-miR-222-3p NTF3 1.50650995841483 1.51287294049382e-09 -1.52188285755702 4.13580352197116e-07 miRNATAP -0.403045186988536 1.66675472357109e-08 NA NA NA hsa-miR-320b NTF3 1.21733873788625 7.99882585998487e-07 -1.52188285755702 4.13580352197116e-07 miRanda -0.253530887922256 0.000656686800975182 NA NA NA hsa-miR-421 NTF3 1.26653675546617 2.35180826009926e-08 -1.52188285755702 4.13580352197116e-07 miRanda -0.209527295648658 0.010372595881473 NA NA NA hsa-miR-590-3p NTF3 0.858742926831233 0.000127281269371976 -1.52188285755702 4.13580352197116e-07 miRanda -0.331302433867045 6.03903167676703e-05 NA NA NA hsa-miR-590-5p NTF3 0.932604531809045 8.39043954167884e-05 -1.52188285755702 4.13580352197116e-07 PITA;miRanda;miRNATAP -0.269857544815155 0.00056237611484518 NA NA NA hsa-miR-16-1-3p NTRK1 1.23864765632542 1.24544799589822e-08 -0.702878820587119 0.00869100750038929 mirMAP -0.322569560542847 1.85068106002081e-05 NA NA NA hsa-miR-185-3p NTRK1 1.38509197368746 3.93425296894499e-10 -0.702878820587119 0.00869100750038929 MirTarget -0.233396014686477 0.00167754248731781 NA NA NA hsa-miR-107 NTRK2 0.85152957824299 1.22369651446858e-11 -0.735609554829713 0.0649549334443704 PITA;miRanda -0.788819949544697 2.93185377478623e-05 NA NA NA hsa-miR-126-5p NTRK2 0.450893496822779 0.0112966412858755 -0.735609554829713 0.0649549334443704 mirMAP -0.450561194987667 0.00103057409287348 NA NA NA hsa-miR-130b-3p NTRK2 1.29757792612022 1.70655148591568e-06 -0.735609554829713 0.0649549334443704 mirMAP -0.590869256310208 3.5541446220163e-12 NA NA NA hsa-miR-130b-5p NTRK2 1.47709791778827 1.34679413565661e-06 -0.735609554829713 0.0649549334443704 mirMAP -0.589041690731238 6.38218699263013e-15 NA NA NA hsa-miR-140-5p NTRK2 0.132398579631585 0.457960134430787 -0.735609554829713 0.0649549334443704 miRanda -0.517252262558507 0.000164756465239872 NA NA NA hsa-miR-142-3p NTRK2 1.80134804047727 3.87649742898476e-07 -0.735609554829713 0.0649549334443704 miRanda -0.373710905276125 1.18114858566622e-08 NA NA NA hsa-miR-142-5p NTRK2 1.08445947321046 0.000126372881543671 -0.735609554829713 0.0649549334443704 mirMAP -0.487256253310974 4.52661725020721e-09 NA NA NA hsa-miR-146b-5p NTRK2 2.23105707690238 3.83997814011313e-23 -0.735609554829713 0.0649549334443704 PITA;miRanda -0.44988387933958 4.70575212047044e-06 NA NA NA hsa-miR-148a-5p NTRK2 0.0805913350009586 0.752183008225566 -0.735609554829713 0.0649549334443704 mirMAP -0.432915283101289 4.82370291577852e-06 NA NA NA hsa-miR-151a-5p NTRK2 0.897578755117332 4.82602190477219e-06 -0.735609554829713 0.0649549334443704 miRNATAP -0.764785472287193 1.3041140281391e-10 NA NA NA hsa-miR-155-5p NTRK2 0.708423342476697 0.00686702252429413 -0.735609554829713 0.0649549334443704 mirMAP -0.594026747418366 3.37579436125982e-11 NA NA NA hsa-miR-15b-3p NTRK2 0.811179945491507 0.000927520880593552 -0.735609554829713 0.0649549334443704 mirMAP -0.742342673756164 2.90450020094243e-15 NA NA NA hsa-miR-17-3p NTRK2 1.37838995268509 5.00444740462873e-13 -0.735609554829713 0.0649549334443704 miRNATAP -0.544155458620334 7.38453081694242e-06 NA NA NA hsa-miR-181a-5p NTRK2 1.39352013383959 4.74824377258519e-17 -0.735609554829713 0.0649549334443704 mirMAP -0.390185038199018 0.00508569398738554 NA NA NA hsa-miR-181b-5p NTRK2 1.44365471425231 6.03807007335243e-15 -0.735609554829713 0.0649549334443704 mirMAP -0.351368420015335 0.0051959091680658 NA NA NA hsa-miR-182-5p NTRK2 1.73826081735237 5.69817940588551e-09 -0.735609554829713 0.0649549334443704 mirMAP -0.482814958915646 3.58916669959507e-10 NA NA NA hsa-miR-185-5p NTRK2 1.20157041272762 3.03584066444936e-15 -0.735609554829713 0.0649549334443704 mirMAP -0.860161259929943 9.44261720495754e-09 NA NA NA hsa-miR-186-5p NTRK2 0.35512789129261 0.0196931838168008 -0.735609554829713 0.0649549334443704 mirMAP -0.999552344549068 1.94769351907846e-10 NA NA NA hsa-miR-200c-3p NTRK2 1.74925752003763 3.42000026705311e-08 -0.735609554829713 0.0649549334443704 miRNAWalker2_validate;miRTarBase -0.499936149880769 4.04191515859561e-12 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 0.703027135708586 0.022464856696655 -0.735609554829713 0.0649549334443704 mirMAP -0.463199819207648 5.91545177688027e-09 NA NA NA hsa-miR-21-5p NTRK2 2.21515015440792 6.0468197386674e-49 -0.735609554829713 0.0649549334443704 mirMAP -0.499987201642294 0.000207874296830454 NA NA NA hsa-miR-22-3p NTRK2 0.530940324058038 8.6675746679475e-07 -0.735609554829713 0.0649549334443704 miRNATAP -0.581052211332341 0.01121910197165 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-26b-5p NTRK2 -0.499493687076043 0.0118149973400486 -0.735609554829713 0.0649549334443704 mirMAP -0.550236699323679 6.14564680932754e-06 NA NA NA hsa-miR-299-5p NTRK2 -0.162422032147768 0.435278723340297 -0.735609554829713 0.0649549334443704 PITA -0.272855803406783 0.0220894771816373 NA NA NA hsa-miR-29a-5p NTRK2 1.00715634051951 4.47499137997344e-07 -0.735609554829713 0.0649549334443704 mirMAP -0.766614931932152 4.35573225843562e-11 NA NA NA hsa-miR-301a-3p NTRK2 1.22580753116505 5.84016077664577e-09 -0.735609554829713 0.0649549334443704 mirMAP -0.628310997135153 1.24204286178959e-08 NA NA NA hsa-miR-30b-5p NTRK2 -0.0106833209203501 0.954966272944722 -0.735609554829713 0.0649549334443704 mirMAP -0.406768990183299 0.00173198311059396 NA NA NA hsa-miR-30d-3p NTRK2 0.0608340295673737 0.708110230223927 -0.735609554829713 0.0649549334443704 mirMAP -0.566751215990719 0.000178969846854659 NA NA NA hsa-miR-30d-5p NTRK2 0.26829866064717 0.0228954180095085 -0.735609554829713 0.0649549334443704 mirMAP -0.598461012717537 0.00475391720340707 NA NA NA hsa-miR-30e-5p NTRK2 -0.284839730810255 0.0405852891523165 -0.735609554829713 0.0649549334443704 mirMAP -0.823434390232863 2.82439643451908e-06 NA NA NA hsa-miR-32-5p NTRK2 0.425717775201634 0.0402079308210921 -0.735609554829713 0.0649549334443704 mirMAP -0.524600042593585 6.69329252901402e-06 NA NA NA hsa-miR-320a NTRK2 0.451741078692272 0.00893327237386749 -0.735609554829713 0.0649549334443704 mirMAP -0.373794187162282 0.00847996420203691 NA NA NA hsa-miR-320b NTRK2 1.21733873788625 7.99882585998487e-07 -0.735609554829713 0.0649549334443704 mirMAP -0.487983758762872 3.08627065378099e-07 NA NA NA hsa-miR-326 NTRK2 -0.552187708067123 0.039648668341622 -0.735609554829713 0.0649549334443704 miRanda -0.34125831952179 0.000159617390991241 NA NA NA hsa-miR-330-5p NTRK2 0.621676971901542 0.00233177378595631 -0.735609554829713 0.0649549334443704 miRanda -0.780752296070769 1.1525570134707e-11 NA NA NA hsa-miR-335-3p NTRK2 2.29463721765513 4.1956113745077e-18 -0.735609554829713 0.0649549334443704 mirMAP -0.284037225247794 0.000958592457033415 NA NA NA hsa-miR-338-3p NTRK2 -0.0138760121093551 0.956163634155272 -0.735609554829713 0.0649549334443704 miRanda -0.476212761701164 5.9713801946439e-07 NA NA NA hsa-miR-339-5p NTRK2 0.51232205151031 0.0560469213103598 -0.735609554829713 0.0649549334443704 miRanda -0.439387437410727 9.12263945694015e-07 NA NA NA hsa-miR-33a-5p NTRK2 0.372183130885047 0.335617783855811 -0.735609554829713 0.0649549334443704 mirMAP -0.34589983246962 1.96930346788678e-08 NA NA NA hsa-miR-340-5p NTRK2 0.344103676703511 0.0160638942614091 -0.735609554829713 0.0649549334443704 mirMAP -0.44114589188109 0.0108334552416571 NA NA NA hsa-miR-342-3p NTRK2 0.235422340773149 0.290471946350276 -0.735609554829713 0.0649549334443704 miRanda -0.338345225091979 0.00206352373640032 NA NA NA hsa-miR-362-5p NTRK2 1.45312548529729 9.37098891085093e-09 -0.735609554829713 0.0649549334443704 mirMAP -0.303228461502123 0.00118575640502558 NA NA NA hsa-miR-369-3p NTRK2 0.644921905467686 0.00104986428608648 -0.735609554829713 0.0649549334443704 mirMAP -0.255937299595059 0.0399916364877497 NA NA NA hsa-miR-421 NTRK2 1.26653675546617 2.35180826009926e-08 -0.735609554829713 0.0649549334443704 mirMAP -0.398458388606326 0.000156881428394467 NA NA NA hsa-miR-429 NTRK2 1.58250682050303 4.75828087352234e-05 -0.735609554829713 0.0649549334443704 PITA;miRanda;miRNATAP -0.444323858086558 1.23328702295408e-13 NA NA NA hsa-miR-454-3p NTRK2 0.823770738595667 1.30339728183332e-05 -0.735609554829713 0.0649549334443704 mirMAP -0.698559866674985 2.37664448511753e-08 NA NA NA hsa-miR-455-3p NTRK2 1.12209231899143 0.00131487017648489 -0.735609554829713 0.0649549334443704 mirMAP -0.347362739148036 3.21858338012547e-07 NA NA NA hsa-miR-501-5p NTRK2 1.59306197632625 2.04856600619363e-09 -0.735609554829713 0.0649549334443704 mirMAP -0.413924883802196 7.24287406766847e-06 NA NA NA hsa-miR-532-5p NTRK2 1.45407925817457 1.88450871132345e-14 -0.735609554829713 0.0649549334443704 PITA -0.490137956559692 5.65196787161211e-05 NA NA NA hsa-miR-576-5p NTRK2 0.872721964495849 5.20470410008775e-05 -0.735609554829713 0.0649549334443704 PITA;mirMAP -0.672882894500366 6.38656593997452e-10 NA NA NA hsa-miR-577 NTRK2 0.615893340074725 0.210494450869356 -0.735609554829713 0.0649549334443704 mirMAP -0.274530157750058 2.28190231430592e-07 NA NA NA hsa-miR-590-3p NTRK2 0.858742926831233 0.000127281269371976 -0.735609554829713 0.0649549334443704 PITA;miRanda;mirMAP -0.728393207132347 2.54231715872411e-12 NA NA NA hsa-miR-590-5p NTRK2 0.932604531809045 8.39043954167884e-05 -0.735609554829713 0.0649549334443704 miRanda;mirMAP -0.623466357921338 3.05181223844614e-10 NA NA NA hsa-miR-940 NTRK2 1.3080677738253 2.0056085433599e-05 -0.735609554829713 0.0649549334443704 PITA -0.392818877674927 7.10516476978407e-07 NA NA NA hsa-let-7d-5p OSMR 0.686819803681087 1.08347860862215e-06 1.07319248891458 2.03893889502661e-07 miRNATAP -0.23030662947324 0.0117808978186706 NA NA NA hsa-let-7g-5p OSMR 0.296128761926282 0.0296823495976068 1.07319248891458 2.03893889502661e-07 miRNATAP -0.366914386996991 0.000126670180730904 NA NA NA hsa-miR-193a-3p OSMR 0.148284355948959 0.379093889907371 1.07319248891458 2.03893889502661e-07 MirTarget -0.162712573212351 0.0362666141398352 NA NA NA hsa-miR-200b-3p OSMR 2.06025765178663 3.07718049337497e-10 1.07319248891458 2.03893889502661e-07 TargetScan -0.1694133215127 6.55580706775718e-06 NA NA NA hsa-miR-335-5p OSMR 0.576542642348884 0.01886326850059 1.07319248891458 2.03893889502661e-07 miRNAWalker2_validate -0.230555874738496 9.77716495468017e-06 NA NA NA hsa-miR-362-3p OSMR 0.994614346444282 4.39793878186399e-05 1.07319248891458 2.03893889502661e-07 miRanda -0.179283837494687 0.000905042314095777 NA NA NA hsa-miR-429 OSMR 1.58250682050303 4.75828087352234e-05 1.07319248891458 2.03893889502661e-07 miRanda;miRNATAP -0.178359964798663 3.88759993052065e-08 NA NA NA hsa-miR-486-5p OSMR -1.52128065772506 4.50915908626354e-09 1.07319248891458 2.03893889502661e-07 miRanda;miRNATAP -0.191305616446065 6.63487754946109e-05 NA NA NA hsa-miR-590-3p OSMR 0.858742926831233 0.000127281269371976 1.07319248891458 2.03893889502661e-07 miRanda;mirMAP;miRNATAP -0.196835764514119 0.000553559166437818 NA NA NA hsa-miR-34c-5p PCK2 1.37406314990472 2.42956736488761e-09 -0.737087881598182 0.000799661186641085 miRanda -0.130125801550415 0.0265421524622638 NA NA NA hsa-miR-576-5p PDGFA 0.872721964495849 5.20470410008775e-05 0.257598781103982 0.151521778368037 mirMAP -0.12517610304965 0.0130147792734934 NA NA NA hsa-miR-590-3p PDGFA 0.858742926831233 0.000127281269371976 0.257598781103982 0.151521778368037 miRanda -0.110631482336875 0.0231100612818728 NA NA NA hsa-miR-29a-3p PDGFB -0.235052170104117 0.138527567930958 0.959240392283124 2.2428871942308e-09 MirTarget;miRNATAP -0.145847917306924 0.0239326490456364 NA NA NA hsa-miR-29b-2-5p PDGFB -0.39718520927539 0.0233851474877787 0.959240392283124 2.2428871942308e-09 mirMAP -0.221681946138974 0.00011899139992161 NA NA NA hsa-miR-29b-3p PDGFB 0.0225365195743876 0.914313337784307 0.959240392283124 2.2428871942308e-09 MirTarget;miRNATAP -0.16817878689874 0.000501334646273791 NA NA NA hsa-miR-29c-3p PDGFB -1.34143813218298 2.77493790306384e-12 0.959240392283124 2.2428871942308e-09 MirTarget;miRNATAP -0.269151839004993 5.9673763192413e-08 NA NA NA hsa-miR-338-5p PDGFB -0.420442436641152 0.0583175290447746 0.959240392283124 2.2428871942308e-09 PITA;miRNATAP -0.162532856329178 0.000347985560710334 NA NA NA hsa-let-7a-3p PDGFC 0.283468597868531 0.127007787220086 -0.330201277237838 0.0648348934349677 mirMAP -0.243050893437576 3.48293226667908e-05 NA NA NA hsa-let-7b-3p PDGFC 0.377956364821509 0.0061730103051373 -0.330201277237838 0.0648348934349677 mirMAP -0.247353652928563 0.00200758724474151 NA NA NA hsa-let-7f-1-3p PDGFC 1.09636075438131 3.42037366931931e-10 -0.330201277237838 0.0648348934349677 mirMAP -0.373245756351649 2.78229666362244e-10 NA NA NA hsa-miR-142-5p PDGFC 1.08445947321046 0.000126372881543671 -0.330201277237838 0.0648348934349677 PITA -0.199949022436403 9.13102195449191e-08 NA NA NA hsa-miR-16-2-3p PDGFC 0.869267463341732 0.000785361809327569 -0.330201277237838 0.0648348934349677 mirMAP -0.279575820643937 4.15083195454231e-12 NA NA NA hsa-miR-330-3p PDGFC 0.391166748754241 0.0581284813543685 -0.330201277237838 0.0648348934349677 mirMAP -0.274673164848722 3.66959091695467e-07 NA NA NA hsa-miR-330-5p PDGFC 0.621676971901542 0.00233177378595631 -0.330201277237838 0.0648348934349677 miRanda -0.262547294714326 5.85557791521718e-07 NA NA NA hsa-miR-335-3p PDGFC 2.29463721765513 4.1956113745077e-18 -0.330201277237838 0.0648348934349677 mirMAP -0.184328995783321 1.28616009770146e-06 NA NA NA hsa-miR-338-5p PDGFC -0.420442436641152 0.0583175290447746 -0.330201277237838 0.0648348934349677 PITA;mirMAP -0.132227755753386 0.00747350883353344 NA NA NA hsa-miR-340-5p PDGFC 0.344103676703511 0.0160638942614091 -0.330201277237838 0.0648348934349677 mirMAP -0.285522009882489 0.000209344525063501 NA NA NA hsa-miR-361-5p PDGFC 0.538048008019709 1.61165802415302e-07 -0.330201277237838 0.0648348934349677 miRanda -0.442312943962021 3.49140175874086e-05 NA NA NA hsa-miR-421 PDGFC 1.26653675546617 2.35180826009926e-08 -0.330201277237838 0.0648348934349677 miRanda -0.280846570757822 1.23269016900133e-09 NA NA NA hsa-miR-450b-5p PDGFC 1.36137774989901 7.45499130609203e-11 -0.330201277237838 0.0648348934349677 mirMAP -0.13838587028811 0.00620336031479655 NA NA NA hsa-miR-486-5p PDGFC -1.52128065772506 4.50915908626354e-09 -0.330201277237838 0.0648348934349677 miRanda -0.14588729683347 0.000338761775550898 NA NA NA hsa-miR-590-3p PDGFC 0.858742926831233 0.000127281269371976 -0.330201277237838 0.0648348934349677 PITA;miRanda;mirMAP -0.312668342863902 2.34329692023921e-11 NA NA NA hsa-miR-7-1-3p PDGFC 0.94398354303717 7.5771319809992e-05 -0.330201277237838 0.0648348934349677 mirMAP -0.280745468939294 1.65871011245085e-10 NA NA NA hsa-miR-7-5p PDGFC 1.20202447072014 0.000123775346787165 -0.330201277237838 0.0648348934349677 miRNAWalker2_validate -0.272845885371186 7.07512335106415e-15 NA NA NA hsa-miR-19b-1-5p PDGFD 1.78323584062047 7.55784857614623e-15 -1.14874460605402 8.02733598895641e-07 MirTarget -0.433617418226878 4.33377527440593e-14 NA NA NA hsa-miR-203a-3p PDGFD 0.986535065247669 0.00954714606545506 -1.14874460605402 8.02733598895641e-07 MirTarget -0.241153762728966 4.59691881543275e-11 NA NA NA hsa-miR-21-5p PDGFD 2.21515015440792 6.0468197386674e-49 -1.14874460605402 8.02733598895641e-07 miRNAWalker2_validate -0.377074482110946 2.14599069029555e-06 NA NA NA hsa-miR-320b PDGFD 1.21733873788625 7.99882585998487e-07 -1.14874460605402 8.02733598895641e-07 miRanda -0.210055651607067 0.000254635292785311 NA NA NA hsa-miR-331-5p PDGFD 0.703863188605486 4.25406757208802e-05 -1.14874460605402 8.02733598895641e-07 MirTarget -0.431389962507477 1.95165142449601e-07 NA NA NA hsa-miR-335-3p PDGFD 2.29463721765513 4.1956113745077e-18 -1.14874460605402 8.02733598895641e-07 mirMAP -0.317982142128345 1.67198690142818e-10 NA NA NA hsa-miR-590-3p PDGFD 0.858742926831233 0.000127281269371976 -1.14874460605402 8.02733598895641e-07 miRanda;mirMAP;miRNATAP -0.252528295864973 7.70762015678756e-05 NA NA NA hsa-miR-590-5p PDGFD 0.932604531809045 8.39043954167884e-05 -1.14874460605402 8.02733598895641e-07 miRanda -0.320933589628964 6.94855806561538e-08 NA NA NA hsa-miR-7-1-3p PDGFD 0.94398354303717 7.5771319809992e-05 -1.14874460605402 8.02733598895641e-07 mirMAP -0.28131759863467 2.17146566295604e-06 NA NA NA hsa-let-7a-3p PDGFRA 0.283468597868531 0.127007787220086 -0.372284813228336 0.00370015308240111 mirMAP -0.164132713355494 0.000104578895690559 NA NA NA hsa-let-7b-3p PDGFRA 0.377956364821509 0.0061730103051373 -0.372284813228336 0.00370015308240111 mirMAP -0.167730114884915 0.00361324460020493 NA NA NA hsa-let-7f-1-3p PDGFRA 1.09636075438131 3.42037366931931e-10 -0.372284813228336 0.00370015308240111 mirMAP -0.220515491007749 3.06639501986851e-07 NA NA NA hsa-let-7g-3p PDGFRA 0.784640358146866 0.0110356862897896 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.114230014889693 4.91772380957852e-06 NA NA NA hsa-miR-106a-5p PDGFRA 0.587427028487119 0.00838999163993323 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.128106918200379 0.000254344317553837 NA NA NA hsa-miR-106b-5p PDGFRA 1.08518388423396 4.82746923373852e-09 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.300706790624407 2.77191136726025e-14 NA NA NA hsa-miR-130b-3p PDGFRA 1.29757792612022 1.70655148591568e-06 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.197048980781642 4.96520163716002e-13 NA NA NA hsa-miR-141-3p PDGFRA 1.76274853293464 9.99331900755725e-07 -0.372284813228336 0.00370015308240111 MirTarget -0.149297215942235 2.6701799609195e-13 NA NA NA hsa-miR-142-5p PDGFRA 1.08445947321046 0.000126372881543671 -0.372284813228336 0.00370015308240111 PITA;mirMAP;miRNATAP -0.108218783983138 7.07396094557756e-05 NA NA NA hsa-miR-146b-5p PDGFRA 2.23105707690238 3.83997814011313e-23 -0.372284813228336 0.00370015308240111 miRanda -0.136098576006454 1.79174981111242e-05 NA NA NA hsa-miR-16-1-3p PDGFRA 1.23864765632542 1.24544799589822e-08 -0.372284813228336 0.00370015308240111 MirTarget -0.244740210309076 2.65373808600922e-12 NA NA NA hsa-miR-17-5p PDGFRA 1.57209612312313 5.10453838016207e-11 -0.372284813228336 0.00370015308240111 MirTarget;TargetScan;miRNATAP -0.216342341586489 1.13394062615413e-12 NA NA NA hsa-miR-181a-5p PDGFRA 1.39352013383959 4.74824377258519e-17 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.153595890144792 0.000587923869515368 NA NA NA hsa-miR-181b-5p PDGFRA 1.44365471425231 6.03807007335243e-15 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.165740409353431 3.64433139973059e-05 NA NA NA hsa-miR-182-5p PDGFRA 1.73826081735237 5.69817940588551e-09 -0.372284813228336 0.00370015308240111 miRNATAP -0.166470416476277 1.45235291123044e-11 NA NA NA hsa-miR-186-5p PDGFRA 0.35512789129261 0.0196931838168008 -0.372284813228336 0.00370015308240111 MirTarget -0.191187638386836 0.000227565470047132 NA NA NA hsa-miR-193a-3p PDGFRA 0.148284355948959 0.379093889907371 -0.372284813228336 0.00370015308240111 miRanda -0.16729022061879 0.00036346082698974 NA NA NA hsa-miR-200a-3p PDGFRA 2.02394729844446 2.21240501925011e-08 -0.372284813228336 0.00370015308240111 MirTarget -0.132237622158925 9.44487536016183e-11 NA NA NA hsa-miR-20a-5p PDGFRA 1.57190995476158 8.72275528729458e-12 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.212543603911107 2.00775083746695e-11 NA NA NA hsa-miR-2110 PDGFRA 0.359318473683641 0.126104910543249 -0.372284813228336 0.00370015308240111 MirTarget -0.111126823177856 0.00172561942794566 NA NA NA hsa-miR-24-3p PDGFRA 0.425646348491286 0.00136678638934554 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.21531644608416 0.000298034706233129 NA NA NA hsa-miR-26b-5p PDGFRA -0.499493687076043 0.0118149973400486 -0.372284813228336 0.00370015308240111 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.105967638296165 0.0075887713337492 NA NA NA hsa-miR-27a-3p PDGFRA 0.523219911315699 0.000116410279757859 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.284977193651823 6.68664603826056e-07 NA NA NA hsa-miR-29a-3p PDGFRA -0.235052170104117 0.138527567930958 -0.372284813228336 0.00370015308240111 MirTarget -0.151602319721592 0.0024567070851308 NA NA NA hsa-miR-29b-1-5p PDGFRA 1.27585983480192 1.70509960024426e-05 -0.372284813228336 0.00370015308240111 mirMAP -0.124476708163236 1.46322320855227e-06 NA NA NA hsa-miR-29b-3p PDGFRA 0.0225365195743876 0.914313337784307 -0.372284813228336 0.00370015308240111 MirTarget -0.190665551162767 2.75318880109294e-07 NA NA NA hsa-miR-301a-3p PDGFRA 1.22580753116505 5.84016077664577e-09 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.176153088771614 8.71946591689107e-07 NA NA NA hsa-miR-320b PDGFRA 1.21733873788625 7.99882585998487e-07 -0.372284813228336 0.00370015308240111 miRanda -0.136241840272357 1.03969245819695e-05 NA NA NA hsa-miR-330-5p PDGFRA 0.621676971901542 0.00233177378595631 -0.372284813228336 0.00370015308240111 miRanda -0.139008399004447 0.000274608508042898 NA NA NA hsa-miR-335-3p PDGFRA 2.29463721765513 4.1956113745077e-18 -0.372284813228336 0.00370015308240111 mirMAP -0.123558608227758 6.79522440678339e-06 NA NA NA hsa-miR-339-5p PDGFRA 0.51232205151031 0.0560469213103598 -0.372284813228336 0.00370015308240111 miRanda -0.120022766918805 3.52086271999685e-05 NA NA NA hsa-miR-33a-5p PDGFRA 0.372183130885047 0.335617783855811 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.114418644531593 7.62046908993567e-09 NA NA NA hsa-miR-34a-5p PDGFRA 0.691825068787607 0.00069818668499891 -0.372284813228336 0.00370015308240111 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.230427604930103 6.32462613820555e-10 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-362-3p PDGFRA 0.994614346444282 4.39793878186399e-05 -0.372284813228336 0.00370015308240111 miRanda -0.183648815551602 1.20460009514809e-08 NA NA NA hsa-miR-421 PDGFRA 1.26653675546617 2.35180826009926e-08 -0.372284813228336 0.00370015308240111 PITA;miRanda;miRNATAP -0.178461839057323 1.00069402648126e-07 NA NA NA hsa-miR-429 PDGFRA 1.58250682050303 4.75828087352234e-05 -0.372284813228336 0.00370015308240111 miRanda;miRNATAP -0.104165136572659 1.43022937772081e-07 NA NA NA hsa-miR-454-3p PDGFRA 0.823770738595667 1.30339728183332e-05 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.199495200963844 8.76518454229892e-07 NA NA NA hsa-miR-455-5p PDGFRA 0.644390760445571 0.00262275997170695 -0.372284813228336 0.00370015308240111 MirTarget;PITA;miRanda -0.109729517569798 0.00267937974123951 NA NA NA hsa-miR-550a-5p PDGFRA 1.55643544666056 8.53097422057455e-09 -0.372284813228336 0.00370015308240111 MirTarget -0.18372796868447 4.20836767257984e-11 NA NA NA hsa-miR-576-5p PDGFRA 0.872721964495849 5.20470410008775e-05 -0.372284813228336 0.00370015308240111 mirMAP -0.225063652915219 1.20915948606908e-10 NA NA NA hsa-miR-589-3p PDGFRA 1.00357906465313 8.20399071001461e-05 -0.372284813228336 0.00370015308240111 mirMAP -0.189536962793885 1.44351313034907e-09 NA NA NA hsa-miR-590-3p PDGFRA 0.858742926831233 0.000127281269371976 -0.372284813228336 0.00370015308240111 miRanda;mirMAP -0.237905498947125 1.1605181451832e-12 NA NA NA hsa-miR-590-5p PDGFRA 0.932604531809045 8.39043954167884e-05 -0.372284813228336 0.00370015308240111 miRanda -0.208860098405412 5.01667276260123e-11 NA NA NA hsa-miR-7-1-3p PDGFRA 0.94398354303717 7.5771319809992e-05 -0.372284813228336 0.00370015308240111 mirMAP -0.167368166484993 1.68043139098927e-07 NA NA NA hsa-miR-93-5p PDGFRA 1.68243825551104 4.62947431501061e-15 -0.372284813228336 0.00370015308240111 MirTarget;miRNATAP -0.214329850257679 2.07697178257257e-10 NA NA NA hsa-miR-96-5p PDGFRA 1.44821155854693 6.56312590328933e-06 -0.372284813228336 0.00370015308240111 TargetScan;miRNATAP -0.173798754312519 1.68968867138383e-12 NA NA NA hsa-miR-29a-3p PDGFRB -0.235052170104117 0.138527567930958 1.58770452426515 4.52165958443608e-16 miRNATAP -0.322355058587592 5.73407180849487e-05 NA NA NA hsa-miR-29b-3p PDGFRB 0.0225365195743876 0.914313337784307 1.58770452426515 4.52165958443608e-16 miRNATAP -0.309980755958488 2.1191069619019e-07 NA NA NA hsa-miR-29c-3p PDGFRB -1.34143813218298 2.77493790306384e-12 1.58770452426515 4.52165958443608e-16 miRNATAP -0.316767712997531 3.95931491893116e-07 NA NA NA hsa-miR-3127-5p PDGFRB 1.27228064385006 2.39461777008663e-07 1.58770452426515 4.52165958443608e-16 mirMAP -0.155216082849527 0.00199824559816844 NA NA NA hsa-miR-338-3p PDGFRB -0.0138760121093551 0.956163634155272 1.58770452426515 4.52165958443608e-16 miRanda -0.17981101802742 0.000328579201626919 NA NA NA hsa-miR-34a-5p PDGFRB 0.691825068787607 0.00069818668499891 1.58770452426515 4.52165958443608e-16 MirTarget -0.148116790543532 0.0167470236958434 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.485361250955594 0.00074097948047418 1.58770452426515 4.52165958443608e-16 MirTarget -0.233063651550583 0.00861694597218669 NA NA NA hsa-miR-484 PDGFRB 0.401753773460753 0.0490851523101605 1.58770452426515 4.52165958443608e-16 mirMAP -0.15871002428374 0.0108344136500376 NA NA NA hsa-miR-486-5p PDGFRB -1.52128065772506 4.50915908626354e-09 1.58770452426515 4.52165958443608e-16 miRanda -0.204672523649349 1.27089317566231e-05 NA NA NA hsa-miR-664a-3p PDGFRB -0.0290482945770787 0.844010225386475 1.58770452426515 4.52165958443608e-16 MirTarget -0.249900335375476 0.00415974387840241 NA NA NA hsa-miR-24-3p PDPK1 0.425646348491286 0.00136678638934554 0.0196196199384167 0.821169574604228 miRNAWalker2_validate -0.11835302793875 0.00302944129876735 NA NA NA hsa-miR-27b-3p PDPK1 -0.439806942644624 0.000523870009254693 0.0196196199384167 0.821169574604228 miRNATAP -0.116323941465303 0.00553738751576204 NA NA NA hsa-miR-126-5p PHLPP2 0.450893496822779 0.0112966412858755 -0.0559191870683584 0.724162909500637 mirMAP -0.111069477967462 0.0419982363307606 NA NA NA hsa-miR-26a-5p PHLPP2 -0.507487084157331 3.23715933371269e-05 -0.0559191870683584 0.724162909500637 mirMAP -0.210266673524405 0.00847778692037529 NA NA NA hsa-miR-26b-5p PHLPP2 -0.499493687076043 0.0118149973400486 -0.0559191870683584 0.724162909500637 miRNAWalker2_validate -0.11405262022763 0.0194351333026617 NA NA NA hsa-miR-27b-3p PHLPP2 -0.439806942644624 0.000523870009254693 -0.0559191870683584 0.724162909500637 MirTarget;miRNATAP -0.158701901821142 0.0401474703686369 NA NA NA hsa-miR-29c-3p PHLPP2 -1.34143813218298 2.77493790306384e-12 -0.0559191870683584 0.724162909500637 miRNATAP -0.117358270099093 0.0155200710232226 NA NA NA hsa-miR-32-5p PHLPP2 0.425717775201634 0.0402079308210921 -0.0559191870683584 0.724162909500637 miRNAWalker2_validate;MirTarget;miRNATAP -0.151377181508915 0.00112673176211886 26276160 MiR 32 contributed to cell proliferation of human breast cancer cells by suppressing of PHLPP2 expression; Mechanically data from luciferase reporter assays revealed that miR-32 directly targeted to the 3'-untranslated region 3'-UTR of PHLPP2 breast cancer hsa-miR-330-3p PHLPP2 0.391166748754241 0.0581284813543685 -0.0559191870683584 0.724162909500637 mirMAP;miRNATAP -0.11228967704413 0.020891265347827 NA NA NA hsa-miR-330-5p PHLPP2 0.621676971901542 0.00233177378595631 -0.0559191870683584 0.724162909500637 miRanda -0.107270042867064 0.0232365732623451 NA NA NA hsa-miR-139-5p PIK3AP1 -1.41674256628297 4.51005988644234e-14 1.67425957934541 1.65691146680239e-14 miRanda -0.358101297937823 3.56244028894821e-07 NA NA NA hsa-miR-30a-3p PIK3AP1 -1.27950866170419 4.33230022379782e-09 1.67425957934541 1.65691146680239e-14 miRNATAP -0.194715879751125 0.00187743483207099 NA NA NA hsa-let-7f-1-3p PIK3CA 1.09636075438131 3.42037366931931e-10 0.194729143482303 0.0690781159814236 mirMAP -0.149666799535812 3.27640116833412e-05 NA NA NA hsa-miR-126-5p PIK3CA 0.450893496822779 0.0112966412858755 0.194729143482303 0.0690781159814236 mirMAP -0.176079552467285 1.17854319899384e-06 NA NA NA hsa-miR-142-5p PIK3CA 1.08445947321046 0.000126372881543671 0.194729143482303 0.0690781159814236 mirMAP -0.105207285665054 2.81345650221239e-06 NA NA NA hsa-miR-148a-5p PIK3CA 0.0805913350009586 0.752183008225566 0.194729143482303 0.0690781159814236 mirMAP -0.141068697957446 1.76544805345295e-08 NA NA NA hsa-miR-148b-3p PIK3CA 0.719517328390822 3.51245964668412e-05 0.194729143482303 0.0690781159814236 miRNAWalker2_validate -0.151852132632465 3.99815835031636e-05 NA NA NA hsa-miR-16-2-3p PIK3CA 0.869267463341732 0.000785361809327569 0.194729143482303 0.0690781159814236 mirMAP -0.124747020505271 3.79598199045172e-07 NA NA NA hsa-miR-186-5p PIK3CA 0.35512789129261 0.0196931838168008 0.194729143482303 0.0690781159814236 mirMAP -0.219315021597991 2.46524180140228e-07 NA NA NA hsa-miR-299-5p PIK3CA -0.162422032147768 0.435278723340297 0.194729143482303 0.0690781159814236 miRNATAP -0.112440708443198 0.000377746778987277 NA NA NA hsa-miR-320a PIK3CA 0.451741078692272 0.00893327237386749 0.194729143482303 0.0690781159814236 miRanda -0.120983312204323 0.00137935065184038 NA NA NA hsa-miR-320b PIK3CA 1.21733873788625 7.99882585998487e-07 0.194729143482303 0.0690781159814236 miRanda -0.11792238486637 4.07051940137235e-06 NA NA NA hsa-miR-335-5p PIK3CA 0.576542642348884 0.01886326850059 0.194729143482303 0.0690781159814236 miRNAWalker2_validate -0.157486721953154 1.19352567503085e-09 NA NA NA hsa-miR-339-5p PIK3CA 0.51232205151031 0.0560469213103598 0.194729143482303 0.0690781159814236 miRanda -0.140334776619182 3.02464392822942e-09 NA NA NA hsa-miR-374b-5p PIK3CA 0.00249900187478502 0.985380083859555 0.194729143482303 0.0690781159814236 mirMAP -0.244906665183641 3.30388405101214e-07 NA NA NA hsa-miR-495-3p PIK3CA -0.024887553302567 0.897251687801771 0.194729143482303 0.0690781159814236 mirMAP -0.105120526037851 0.00201725997019777 NA NA NA hsa-miR-576-5p PIK3CA 0.872721964495849 5.20470410008775e-05 0.194729143482303 0.0690781159814236 PITA -0.134756577377079 5.1634273931206e-06 NA NA NA hsa-miR-582-3p PIK3CA -0.104548775434833 0.640423116430294 0.194729143482303 0.0690781159814236 miRNATAP -0.102887637441851 0.000413241156874094 NA NA NA hsa-miR-590-3p PIK3CA 0.858742926831233 0.000127281269371976 0.194729143482303 0.0690781159814236 miRanda;mirMAP -0.174809526517214 4.67478841800302e-10 NA NA NA hsa-miR-590-5p PIK3CA 0.932604531809045 8.39043954167884e-05 0.194729143482303 0.0690781159814236 miRanda -0.157815325131793 2.83126566928395e-09 NA NA NA hsa-miR-7-1-3p PIK3CA 0.94398354303717 7.5771319809992e-05 0.194729143482303 0.0690781159814236 mirMAP -0.1534743423884 5.95162340489971e-09 NA NA NA hsa-miR-96-5p PIK3CA 1.44821155854693 6.56312590328933e-06 0.194729143482303 0.0690781159814236 TargetScan -0.102925641162433 8.65462553903472e-07 NA NA NA hsa-miR-130a-3p PIK3CB 0.218018009582956 0.274232880676821 0.487972336438506 1.06256864389617e-06 miRNATAP -0.120118816720037 0.000110881261212529 NA NA NA hsa-miR-195-3p PIK3CB -0.694544351365025 0.000214711021317786 0.487972336438506 1.06256864389617e-06 mirMAP -0.13885789455157 2.11127592118759e-05 NA NA NA hsa-miR-29c-3p PIK3CB -1.34143813218298 2.77493790306384e-12 0.487972336438506 1.06256864389617e-06 miRNATAP -0.144829450024151 2.36364789406086e-06 NA NA NA hsa-miR-30b-3p PIK3CD 0.252088263642787 0.216818735503048 -0.0311608960188332 0.85393242590672 MirTarget -0.211088025518264 2.94456229839616e-05 NA NA NA hsa-miR-30b-5p PIK3CD -0.0106833209203501 0.954966272944722 -0.0311608960188332 0.85393242590672 MirTarget -0.127049707365963 0.0210868789471298 NA NA NA hsa-miR-30d-5p PIK3CD 0.26829866064717 0.0228954180095085 -0.0311608960188332 0.85393242590672 MirTarget;miRNATAP -0.466167464019275 1.12163448330828e-07 NA NA NA hsa-miR-320b PIK3CD 1.21733873788625 7.99882585998487e-07 -0.0311608960188332 0.85393242590672 miRanda -0.102820646245335 0.0122324482672438 NA NA NA hsa-miR-324-5p PIK3CD 0.800946351685734 0.00101337664367375 -0.0311608960188332 0.85393242590672 miRanda -0.103806782901193 0.0136389205564886 NA NA NA hsa-miR-421 PIK3CD 1.26653675546617 2.35180826009926e-08 -0.0311608960188332 0.85393242590672 miRanda -0.130990705864954 0.00343678307821204 NA NA NA hsa-miR-7-5p PIK3CD 1.20202447072014 0.000123775346787165 -0.0311608960188332 0.85393242590672 miRTarBase;MirTarget;miRNATAP -0.110713446527457 0.00139815102421271 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-335-3p PIK3CG 2.29463721765513 4.1956113745077e-18 -0.431523776023951 0.105004494916123 mirMAP -0.236740995358545 3.30421401118699e-05 NA NA NA hsa-miR-421 PIK3CG 1.26653675546617 2.35180826009926e-08 -0.431523776023951 0.105004494916123 miRanda -0.222678259072787 0.00161023125714365 NA NA NA hsa-miR-502-5p PIK3CG 0.873538712251823 0.0012275719769761 -0.431523776023951 0.105004494916123 miRNATAP -0.17829233844257 0.0107350853192294 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-103a-3p PIK3R1 1.01322687786547 1.60813894223583e-11 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.142182303458125 0.0145875882589141 NA NA NA hsa-miR-106a-5p PIK3R1 0.587427028487119 0.00838999163993323 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.130078677669931 0.00118702908974724 NA NA NA hsa-miR-106b-5p PIK3R1 1.08518388423396 4.82746923373852e-09 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.336490450570336 1.05499898679502e-13 NA NA NA hsa-miR-107 PIK3R1 0.85152957824299 1.22369651446858e-11 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;miRNATAP -0.378607761454031 3.44237135388333e-08 NA NA NA hsa-miR-127-5p PIK3R1 0.809791853526294 0.000176206263785639 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.134990087766039 0.00103777674997171 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 0.835320684237761 1.85756253116961e-09 -0.132584613334835 0.368540743016032 MirTarget -0.331667618921103 1.07700590510387e-07 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 1.62626930622185 2.81303026159352e-11 -0.132584613334835 0.368540743016032 MirTarget -0.19681995249176 1.25142656850692e-08 NA NA NA hsa-miR-144-3p PIK3R1 -1.37061426401952 5.85913017989725e-05 -0.132584613334835 0.368540743016032 mirMAP -0.149728529455162 5.90199570068709e-09 NA NA NA hsa-miR-15a-5p PIK3R1 1.07800995489566 4.32072598796529e-10 -0.132584613334835 0.368540743016032 MirTarget -0.275758710579712 2.66786829582786e-08 NA NA NA hsa-miR-15b-5p PIK3R1 0.637819606405168 0.000580041575431604 -0.132584613334835 0.368540743016032 MirTarget -0.332164490578092 8.24319047412396e-13 NA NA NA hsa-miR-16-2-3p PIK3R1 0.869267463341732 0.000785361809327569 -0.132584613334835 0.368540743016032 MirTarget -0.270797792212755 7.78030324480662e-17 NA NA NA hsa-miR-16-5p PIK3R1 0.468459442059375 0.02635007201346 -0.132584613334835 0.368540743016032 MirTarget -0.331876883174364 1.84458792077216e-16 NA NA NA hsa-miR-17-5p PIK3R1 1.57209612312313 5.10453838016207e-11 -0.132584613334835 0.368540743016032 MirTarget;TargetScan;miRNATAP -0.205461506194231 5.82189035871477e-09 NA NA NA hsa-miR-182-5p PIK3R1 1.73826081735237 5.69817940588551e-09 -0.132584613334835 0.368540743016032 miRNATAP -0.195062710695262 3.86910965362375e-12 NA NA NA hsa-miR-185-5p PIK3R1 1.20157041272762 3.03584066444936e-15 -0.132584613334835 0.368540743016032 miRNATAP -0.331680219553521 1.5899202510864e-09 NA NA NA hsa-miR-186-5p PIK3R1 0.35512789129261 0.0196931838168008 -0.132584613334835 0.368540743016032 mirMAP -0.443671404478921 5.01409205354306e-15 NA NA NA hsa-miR-188-5p PIK3R1 1.57437249320621 2.78824007819973e-08 -0.132584613334835 0.368540743016032 MirTarget -0.138656197885074 1.597564629934e-05 NA NA NA hsa-miR-200b-3p PIK3R1 2.06025765178663 3.07718049337497e-10 -0.132584613334835 0.368540743016032 mirMAP -0.190323937293919 4.94804536331339e-14 NA NA NA hsa-miR-200c-3p PIK3R1 1.74925752003763 3.42000026705311e-08 -0.132584613334835 0.368540743016032 mirMAP -0.218718536239199 3.75780637473004e-17 NA NA NA hsa-miR-20a-5p PIK3R1 1.57190995476158 8.72275528729458e-12 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.130281803040919 0.000485243379752592 NA NA NA hsa-miR-21-5p PIK3R1 2.21515015440792 6.0468197386674e-49 -0.132584613334835 0.368540743016032 miRNAWalker2_validate;MirTarget;miRNATAP -0.149170797978773 0.00275496702870304 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.810640598956005 2.08058512206955e-06 -0.132584613334835 0.368540743016032 MirTarget -0.201364520132149 9.76595689156252e-05 NA NA NA hsa-miR-22-5p PIK3R1 0.668839167786886 0.00102248931590479 -0.132584613334835 0.368540743016032 mirMAP -0.283079357243757 2.60043419499455e-11 NA NA NA hsa-miR-221-3p PIK3R1 1.11809809289021 6.56903442847056e-08 -0.132584613334835 0.368540743016032 MirTarget -0.286726960767047 2.28472885436058e-12 NA NA NA hsa-miR-222-3p PIK3R1 1.50650995841483 1.51287294049382e-09 -0.132584613334835 0.368540743016032 MirTarget -0.271001919790177 2.35665812286189e-16 NA NA NA hsa-miR-29a-3p PIK3R1 -0.235052170104117 0.138527567930958 -0.132584613334835 0.368540743016032 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.283923645063458 4.63143348819464e-07 NA NA NA hsa-miR-29b-3p PIK3R1 0.0225365195743876 0.914313337784307 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.268280450015629 1.38687845300335e-10 NA NA NA hsa-miR-320a PIK3R1 0.451741078692272 0.00893327237386749 -0.132584613334835 0.368540743016032 miRNATAP -0.160922707834791 0.00201959794696513 NA NA NA hsa-miR-320b PIK3R1 1.21733873788625 7.99882585998487e-07 -0.132584613334835 0.368540743016032 miRNATAP -0.226506038658528 5.45267288733949e-11 NA NA NA hsa-miR-324-3p PIK3R1 0.903513852828114 7.41223794911022e-07 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.285021076398905 1.60294449084084e-09 NA NA NA hsa-miR-330-3p PIK3R1 0.391166748754241 0.0581284813543685 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.250685072184435 1.32131838823197e-08 NA NA NA hsa-miR-3607-3p PIK3R1 0.479939234340415 0.251616873367277 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.11392823791827 1.4389331266431e-07 NA NA NA hsa-miR-361-5p PIK3R1 0.538048008019709 1.61165802415302e-07 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.264285643241021 0.00281945473241426 NA NA NA hsa-miR-369-3p PIK3R1 0.644921905467686 0.00104986428608648 -0.132584613334835 0.368540743016032 PITA -0.175508362020099 0.000110361870932148 NA NA NA hsa-miR-374a-3p PIK3R1 0.0703956336838676 0.602396227448772 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.203181865162707 0.00271937754974667 NA NA NA hsa-miR-409-3p PIK3R1 1.02296003511803 1.54748197930307e-08 -0.132584613334835 0.368540743016032 mirMAP -0.145382126407499 0.00276980374621516 NA NA NA hsa-miR-424-5p PIK3R1 0.956135912596328 0.00035164943928494 -0.132584613334835 0.368540743016032 MirTarget -0.206889102675453 1.32836395451424e-10 NA NA NA hsa-miR-429 PIK3R1 1.58250682050303 4.75828087352234e-05 -0.132584613334835 0.368540743016032 mirMAP;miRNATAP -0.192620146255309 4.11623188242549e-19 NA NA NA hsa-miR-450b-5p PIK3R1 1.36137774989901 7.45499130609203e-11 -0.132584613334835 0.368540743016032 miRNATAP -0.127689312952549 0.00207332506528985 NA NA NA hsa-miR-455-3p PIK3R1 1.12209231899143 0.00131487017648489 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.155821698046641 2.793759765901e-10 NA NA NA hsa-miR-486-5p PIK3R1 -1.52128065772506 4.50915908626354e-09 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;miRNATAP -0.111517124883819 0.000872296997974682 25475121 Mechanistically miR-486-5p was confirmed to directly target PIK3R1 expression thereby suppressing phosphatidylinositol 3-kinase-AKT pathway activation by dual luciferase reporter assay and real-time quantitative RT-PCR and western blot analysis; In addition PIK3R1 knockdown mimicked the effects of miR-486-5p overexpression by inhibiting HCC growth migration and invasion; Furthermore correlation analysis Kaplan-Meier estimates and Cox proportional hazard models showed an inverse correlation between miR-486-5p and PIK3R1 as well as a shorter time to recurrence after HCC resection in patients with lower miR-486-5p expression; Hence we conclude that miR-486-5p which is frequently downregulated in HCC inhibits HCC progression by targeting PIK3R1 and phosphatidylinositol 3-kinase-AKT activation recurrence;progression liver cancer hsa-miR-493-5p PIK3R1 1.32223598235404 3.01688809960418e-10 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.177956302441626 1.44369707660942e-05 NA NA NA hsa-miR-495-3p PIK3R1 -0.024887553302567 0.897251687801771 -0.132584613334835 0.368540743016032 mirMAP -0.112059530241924 0.0172611826398109 NA NA NA hsa-miR-532-3p PIK3R1 1.35968112631236 2.41509711096659e-06 -0.132584613334835 0.368540743016032 MirTarget -0.188788796166485 1.81630429981725e-10 NA NA NA hsa-miR-542-3p PIK3R1 1.12416854979951 1.02649534578738e-12 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda -0.124824165626404 0.0236577831714213 NA NA NA hsa-miR-582-5p PIK3R1 0.0720675907490005 0.728284850619144 -0.132584613334835 0.368540743016032 mirMAP -0.195748699479339 5.38518019551405e-06 NA NA NA hsa-miR-589-3p PIK3R1 1.00357906465313 8.20399071001461e-05 -0.132584613334835 0.368540743016032 mirMAP -0.19207222979387 1.00729738499744e-07 NA NA NA hsa-miR-590-3p PIK3R1 0.858742926831233 0.000127281269371976 -0.132584613334835 0.368540743016032 miRanda;mirMAP -0.306685343313858 4.00860799504336e-16 NA NA NA hsa-miR-590-5p PIK3R1 0.932604531809045 8.39043954167884e-05 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;miRNATAP -0.26961119042859 5.68457893013219e-14 NA NA NA hsa-miR-629-3p PIK3R1 0.597278340934362 0.0508108703940013 -0.132584613334835 0.368540743016032 MirTarget -0.213641933124726 1.40141884423934e-12 NA NA NA hsa-miR-654-3p PIK3R1 -0.141140644392039 0.545807044192286 -0.132584613334835 0.368540743016032 mirMAP -0.106804874473743 0.00563135914162428 NA NA NA hsa-miR-93-5p PIK3R1 1.68243825551104 4.62947431501061e-15 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.1664038546685 2.34893767088624e-05 NA NA NA hsa-miR-96-5p PIK3R1 1.44821155854693 6.56312590328933e-06 -0.132584613334835 0.368540743016032 TargetScan;miRNATAP -0.166674403190105 5.26906773814753e-09 NA NA NA hsa-miR-133a-3p PIK3R2 -2.63342156915404 5.72661351480585e-12 0.6802233434179 1.14371526174319e-06 miRNAWalker2_validate -0.113207314566063 1.18348525180172e-07 NA NA NA hsa-miR-30a-5p PIK3R2 -0.742755040631906 3.79943871404435e-05 0.6802233434179 1.14371526174319e-06 miRNATAP -0.254082730397951 6.3354742949341e-08 NA NA NA hsa-miR-136-5p PIK3R3 0.501768051727903 0.0272130411225693 0.229241319600778 0.105783008441893 mirMAP -0.119545709964546 0.00163980471910892 NA NA NA hsa-miR-148b-3p PIK3R3 0.719517328390822 3.51245964668412e-05 0.229241319600778 0.105783008441893 mirMAP;miRNATAP -0.127248050375296 0.0101379445644198 24632606 Altered p53 regulation of miR 148b and p55PIK contributes to tumor progression in colorectal cancer; In this study we show that miR-148b binds specifically to the 3'-untranslated region of p55PIK and significantly suppresses p55PIK expression; MiR-148b overexpression abolished p55PIK stimulation of cell proliferation and cell cycle progression in colorectal cancer CRC cell lines and decreased tumor growth in vivo; In CRC cell lines and tissues p53 expression was associated with miR-148b expression and both were negatively associated with p55PIK expression progression colorectal cancer hsa-miR-19b-3p PIK3R3 0.936987029203338 9.28141970787798e-06 0.229241319600778 0.105783008441893 MirTarget;miRNATAP -0.109126830954357 0.00691702665683187 NA NA NA hsa-miR-25-3p PIK3R3 0.948739680210032 3.62304579611938e-09 0.229241319600778 0.105783008441893 MirTarget -0.11205754710572 0.0340829353902195 NA NA NA hsa-miR-26a-5p PIK3R3 -0.507487084157331 3.23715933371269e-05 0.229241319600778 0.105783008441893 miRNATAP -0.209073335478335 0.00343291357619903 NA NA NA hsa-miR-26b-5p PIK3R3 -0.499493687076043 0.0118149973400486 0.229241319600778 0.105783008441893 miRNATAP -0.121369160993845 0.00540425919442956 NA NA NA hsa-miR-32-5p PIK3R3 0.425717775201634 0.0402079308210921 0.229241319600778 0.105783008441893 MirTarget;miRNATAP -0.153402094339603 0.000220452047926588 NA NA NA hsa-miR-365a-3p PIK3R3 -0.801671336684825 1.28258342849568e-06 0.229241319600778 0.105783008441893 MirTarget -0.1392740113137 0.00709186083170874 NA NA NA hsa-miR-369-3p PIK3R3 0.644921905467686 0.00104986428608648 0.229241319600778 0.105783008441893 PITA -0.169433183932675 0.000105326046123099 NA NA NA hsa-miR-381-3p PIK3R3 -0.163029390855052 0.306162657669783 0.229241319600778 0.105783008441893 mirMAP -0.140900581723428 0.0104447671749475 NA NA NA hsa-miR-495-3p PIK3R3 -0.024887553302567 0.897251687801771 0.229241319600778 0.105783008441893 mirMAP -0.110726086516907 0.0144929938591346 NA NA NA hsa-miR-654-3p PIK3R3 -0.141140644392039 0.545807044192286 0.229241319600778 0.105783008441893 PITA;miRNATAP -0.121763071562714 0.00100702070926152 NA NA NA hsa-miR-182-5p PIK3R5 1.73826081735237 5.69817940588551e-09 0.173685984363141 0.418027202475398 MirTarget -0.109303293886238 0.0102270829052502 NA NA NA hsa-miR-18a-3p PIK3R5 1.42489363201958 4.87914808744785e-05 0.173685984363141 0.418027202475398 MirTarget -0.103577402155963 0.0120289887456205 NA NA NA hsa-miR-149-5p PIK3R6 -0.814305489055795 0.00575972754574164 0.32177588673662 0.0742240813907701 MirTarget -0.145296496628701 8.02330494616718e-05 NA NA NA hsa-let-7a-3p PKN2 0.283468597868531 0.127007787220086 0.12905462493587 0.242993902547613 miRNATAP -0.137831169405764 0.000139184112261526 NA NA NA hsa-let-7b-3p PKN2 0.377956364821509 0.0061730103051373 0.12905462493587 0.242993902547613 miRNATAP -0.105261863447993 0.0332875007539964 NA NA NA hsa-miR-126-5p PKN2 0.450893496822779 0.0112966412858755 0.12905462493587 0.242993902547613 mirMAP -0.160043946075831 2.00279811857373e-05 NA NA NA hsa-miR-127-3p PKN2 0.480219800701855 0.00500448678268473 0.12905462493587 0.242993902547613 MirTarget;miRanda -0.164624662145475 2.48520024232958e-05 NA NA NA hsa-miR-140-5p PKN2 0.132398579631585 0.457960134430787 0.12905462493587 0.242993902547613 MirTarget;miRanda -0.190567173330649 3.42221360104056e-07 NA NA NA hsa-miR-199a-5p PKN2 0.723739336873244 5.69674696426761e-05 0.12905462493587 0.242993902547613 miRNATAP -0.144279899332391 9.20027488093684e-05 NA NA NA hsa-miR-218-5p PKN2 -0.615157868107884 0.00447149109697709 0.12905462493587 0.242993902547613 MirTarget -0.20898791735949 2.33798703927448e-12 NA NA NA hsa-miR-27a-3p PKN2 0.523219911315699 0.000116410279757859 0.12905462493587 0.242993902547613 miRNATAP -0.115999607291636 0.0201172437430744 NA NA NA hsa-miR-27b-3p PKN2 -0.439806942644624 0.000523870009254693 0.12905462493587 0.242993902547613 miRNATAP -0.178660785840575 0.000837966261950074 NA NA NA hsa-miR-34c-5p PKN2 1.37406314990472 2.42956736488761e-09 0.12905462493587 0.242993902547613 miRanda -0.105308434429452 0.000263896491552814 NA NA NA hsa-miR-495-3p PKN2 -0.024887553302567 0.897251687801771 0.12905462493587 0.242993902547613 mirMAP -0.136246920286442 9.42570296403049e-05 NA NA NA hsa-miR-664a-3p PKN2 -0.0290482945770787 0.844010225386475 0.12905462493587 0.242993902547613 MirTarget -0.113793594421835 0.0141013101753007 NA NA NA hsa-miR-421 PPP2CB 1.26653675546617 2.35180826009926e-08 -0.511848600249399 2.66807577441834e-06 miRNAWalker2_validate;miRanda -0.114006096656868 9.23001960871675e-05 NA NA NA hsa-miR-125a-5p PPP2R1B -0.261743402170195 0.116107665196876 0.141286513472044 0.201665698854979 PITA;miRanda -0.10968035470595 0.00719472046068446 NA NA NA hsa-miR-139-5p PPP2R1B -1.41674256628297 4.51005988644234e-14 0.141286513472044 0.201665698854979 MirTarget;miRanda -0.137998716815882 4.88944980532178e-05 NA NA NA hsa-miR-195-5p PPP2R1B -1.07154705036962 4.16544134775761e-08 0.141286513472044 0.201665698854979 MirTarget -0.13157210220167 8.49104716697063e-05 NA NA NA hsa-miR-30a-3p PPP2R1B -1.27950866170419 4.33230022379782e-09 0.141286513472044 0.201665698854979 mirMAP -0.183101665830488 3.43061240330759e-10 NA NA NA hsa-miR-30a-5p PPP2R1B -0.742755040631906 3.79943871404435e-05 0.141286513472044 0.201665698854979 miRNATAP -0.216706125776355 1.94228862060271e-09 NA NA NA hsa-miR-30c-2-3p PPP2R1B -0.850499600024184 1.80492410494116e-05 0.141286513472044 0.201665698854979 MirTarget -0.17777311930786 6.56503377240636e-08 NA NA NA hsa-miR-497-5p PPP2R1B -0.486115215577409 0.00973897247186318 0.141286513472044 0.201665698854979 MirTarget -0.116415602488678 0.00113149556019452 NA NA NA hsa-miR-107 PPP2R2B 0.85152957824299 1.22369651446858e-11 -1.3770929769554 5.91525129445251e-07 miRanda -1.07756145502029 1.70487052866375e-17 NA NA NA hsa-miR-10a-3p PPP2R2B 0.673742947104233 0.000577781470262632 -1.3770929769554 5.91525129445251e-07 mirMAP -0.2912263297804 0.00109143997087202 NA NA NA hsa-miR-126-5p PPP2R2B 0.450893496822779 0.0112966412858755 -1.3770929769554 5.91525129445251e-07 MirTarget -0.30196769118162 0.00184438367572957 NA NA NA hsa-miR-141-3p PPP2R2B 1.76274853293464 9.99331900755725e-07 -1.3770929769554 5.91525129445251e-07 TargetScan -0.402082861730495 2.17750327971907e-20 NA NA NA hsa-miR-361-5p PPP2R2B 0.538048008019709 1.61165802415302e-07 -1.3770929769554 5.91525129445251e-07 miRanda -0.931774220298543 2.03327535488499e-08 NA NA NA hsa-miR-7-1-3p PPP2R2B 0.94398354303717 7.5771319809992e-05 -1.3770929769554 5.91525129445251e-07 mirMAP -0.489445399099362 9.48886609349691e-13 NA NA NA hsa-miR-10a-3p PPP2R2C 0.673742947104233 0.000577781470262632 -0.958837674641367 0.0742814866895039 mirMAP -0.337841157980333 0.0487545646563286 NA NA NA hsa-miR-142-3p PPP2R2C 1.80134804047727 3.87649742898476e-07 -0.958837674641367 0.0742814866895039 miRNAWalker2_validate -0.483585782088173 4.72919313177457e-08 NA NA NA hsa-miR-148b-5p PPP2R2C 0.7888996589349 0.00420956802908159 -0.958837674641367 0.0742814866895039 mirMAP -0.287881557660934 0.0245282954295816 NA NA NA hsa-miR-181b-5p PPP2R2C 1.44365471425231 6.03807007335243e-15 -0.958837674641367 0.0742814866895039 mirMAP -0.559693554693011 0.000923635319845671 NA NA NA hsa-miR-192-5p PPP2R2C 2.0867723747501 3.57854249239079e-08 -0.958837674641367 0.0742814866895039 mirMAP -0.466957895421551 1.47582848585611e-08 NA NA NA hsa-miR-194-5p PPP2R2C 2.24386881692218 9.35116329002209e-11 -0.958837674641367 0.0742814866895039 miRNATAP -0.503596467198651 1.66655805533143e-08 NA NA NA hsa-miR-200b-3p PPP2R2C 2.06025765178663 3.07718049337497e-10 -0.958837674641367 0.0742814866895039 TargetScan -0.341920658891564 0.000391136109564967 NA NA NA hsa-miR-200c-3p PPP2R2C 1.74925752003763 3.42000026705311e-08 -0.958837674641367 0.0742814866895039 miRNATAP -0.310396062921359 0.00205801508719287 NA NA NA hsa-miR-339-5p PPP2R2C 0.51232205151031 0.0560469213103598 -0.958837674641367 0.0742814866895039 miRanda -0.293805440424373 0.0166672260640679 NA NA NA hsa-miR-429 PPP2R2C 1.58250682050303 4.75828087352234e-05 -0.958837674641367 0.0742814866895039 PITA;miRanda;miRNATAP -0.271718471862724 0.00125225062676896 NA NA NA hsa-miR-500a-3p PPP2R2C 1.51438197609577 4.33054210292228e-12 -0.958837674641367 0.0742814866895039 MirTarget -0.467858102397338 0.00117814426773339 NA NA NA hsa-miR-501-3p PPP2R2C 1.88467797720099 9.65178855450719e-15 -0.958837674641367 0.0742814866895039 MirTarget;PITA;TargetScan;miRNATAP -0.413201978517556 0.00126869781115236 NA NA NA hsa-miR-502-3p PPP2R2C 0.989057260587538 3.37032335853725e-07 -0.958837674641367 0.0742814866895039 MirTarget;PITA;miRNATAP -0.552742250074094 0.000889267528576853 NA NA NA hsa-miR-542-3p PPP2R2C 1.12416854979951 1.02649534578738e-12 -0.958837674641367 0.0742814866895039 miRanda -0.477590398523655 0.0180478689152835 NA NA NA hsa-miR-590-3p PPP2R2C 0.858742926831233 0.000127281269371976 -0.958837674641367 0.0742814866895039 miRanda -0.745578571550205 1.88832489500353e-07 NA NA NA hsa-miR-625-5p PPP2R2C 0.748754910408313 0.00783938428700196 -0.958837674641367 0.0742814866895039 MirTarget -0.626607798656268 5.99518824753458e-08 NA NA NA hsa-miR-106a-5p PPP2R3A 0.587427028487119 0.00838999163993323 -1.49546518768918 1.3186881218446e-09 mirMAP -0.211107109474297 0.00243004919507343 NA NA NA hsa-miR-106b-5p PPP2R3A 1.08518388423396 4.82746923373852e-09 -1.49546518768918 1.3186881218446e-09 mirMAP -0.748195299608508 3.52730939689617e-23 NA NA NA hsa-miR-128-3p PPP2R3A 0.835320684237761 1.85756253116961e-09 -1.49546518768918 1.3186881218446e-09 MirTarget -0.867448846949205 8.22394430731531e-17 NA NA NA hsa-miR-140-5p PPP2R3A 0.132398579631585 0.457960134430787 -1.49546518768918 1.3186881218446e-09 PITA;miRanda;miRNATAP -0.419747871173102 1.32689821549195e-06 NA NA NA hsa-miR-148b-3p PPP2R3A 0.719517328390822 3.51245964668412e-05 -1.49546518768918 1.3186881218446e-09 miRNAWalker2_validate -0.608193952428364 1.14511210283544e-12 NA NA NA hsa-miR-17-5p PPP2R3A 1.57209612312313 5.10453838016207e-11 -1.49546518768918 1.3186881218446e-09 mirMAP -0.55839444810494 5.72916448449567e-22 NA NA NA hsa-miR-181a-5p PPP2R3A 1.39352013383959 4.74824377258519e-17 -1.49546518768918 1.3186881218446e-09 MirTarget -0.600569165647386 2.0753137620857e-12 NA NA NA hsa-miR-181b-5p PPP2R3A 1.44365471425231 6.03807007335243e-15 -1.49546518768918 1.3186881218446e-09 MirTarget -0.533642314186814 4.90347323307013e-12 NA NA NA hsa-miR-186-5p PPP2R3A 0.35512789129261 0.0196931838168008 -1.49546518768918 1.3186881218446e-09 MirTarget;mirMAP -0.640534649144768 1.57004282542683e-10 NA NA NA hsa-miR-20a-5p PPP2R3A 1.57190995476158 8.72275528729458e-12 -1.49546518768918 1.3186881218446e-09 mirMAP -0.544767188351152 3.1098135354474e-19 NA NA NA hsa-miR-26a-2-3p PPP2R3A 0.0619487388777404 0.765401751442771 -1.49546518768918 1.3186881218446e-09 mirMAP -0.187005101049086 0.0148199170562492 NA NA NA hsa-miR-26b-5p PPP2R3A -0.499493687076043 0.0118149973400486 -1.49546518768918 1.3186881218446e-09 miRNATAP -0.279334238025198 0.000352882065207545 NA NA NA hsa-miR-30b-3p PPP2R3A 0.252088263642787 0.216818735503048 -1.49546518768918 1.3186881218446e-09 MirTarget -0.294664625186861 0.00011654257554766 NA NA NA hsa-miR-320a PPP2R3A 0.451741078692272 0.00893327237386749 -1.49546518768918 1.3186881218446e-09 miRanda -0.326598900203321 0.000286026309578298 NA NA NA hsa-miR-320b PPP2R3A 1.21733873788625 7.99882585998487e-07 -1.49546518768918 1.3186881218446e-09 miRanda -0.379772379594063 2.50690653348859e-10 NA NA NA hsa-miR-34a-5p PPP2R3A 0.691825068787607 0.00069818668499891 -1.49546518768918 1.3186881218446e-09 MirTarget;miRNATAP -0.546278618621513 5.1342465884017e-14 NA NA NA hsa-miR-3614-5p PPP2R3A 0.288051497709626 0.339707047011435 -1.49546518768918 1.3186881218446e-09 MirTarget -0.264574368449748 2.90344815987067e-06 NA NA NA hsa-miR-429 PPP2R3A 1.58250682050303 4.75828087352234e-05 -1.49546518768918 1.3186881218446e-09 miRanda -0.289150850776749 3.40620811673886e-14 NA NA NA hsa-miR-502-5p PPP2R3A 0.873538712251823 0.0012275719769761 -1.49546518768918 1.3186881218446e-09 miRNATAP -0.338150876353676 2.50684664015504e-07 NA NA NA hsa-miR-542-3p PPP2R3A 1.12416854979951 1.02649534578738e-12 -1.49546518768918 1.3186881218446e-09 miRanda -0.457302672670885 1.13143303499285e-06 NA NA NA hsa-miR-576-5p PPP2R3A 0.872721964495849 5.20470410008775e-05 -1.49546518768918 1.3186881218446e-09 PITA;mirMAP -0.516448165618588 3.7186194869302e-14 NA NA NA hsa-miR-577 PPP2R3A 0.615893340074725 0.210494450869356 -1.49546518768918 1.3186881218446e-09 MirTarget -0.242210613239581 2.11774327064448e-13 NA NA NA hsa-miR-589-5p PPP2R3A 1.20000320800112 1.34209467040505e-13 -1.49546518768918 1.3186881218446e-09 MirTarget -0.723739766367836 1.10951496532203e-16 NA NA NA hsa-miR-590-3p PPP2R3A 0.858742926831233 0.000127281269371976 -1.49546518768918 1.3186881218446e-09 MirTarget;PITA;miRanda -0.513943696897959 4.72914134944415e-15 NA NA NA hsa-miR-628-5p PPP2R3A -0.0242002274581137 0.900266755757793 -1.49546518768918 1.3186881218446e-09 MirTarget -0.25707408464166 0.00151873089377237 NA NA NA hsa-miR-93-5p PPP2R3A 1.68243825551104 4.62947431501061e-15 -1.49546518768918 1.3186881218446e-09 mirMAP -0.548937813060352 2.70184550050723e-17 NA NA NA hsa-miR-185-3p PPP2R5B 1.38509197368746 3.93425296894499e-10 -0.243058048013626 0.0211699067670468 MirTarget -0.160241626816619 1.77798553041735e-08 NA NA NA hsa-miR-330-5p PPP2R5B 0.621676971901542 0.00233177378595631 -0.243058048013626 0.0211699067670468 MirTarget;miRanda;miRNATAP -0.1157323889275 0.000211939170760146 NA NA NA hsa-miR-331-3p PPP2R5B 0.818192524829557 0.000359485856225569 -0.243058048013626 0.0211699067670468 MirTarget;miRNATAP -0.112963272079311 4.23573461221573e-05 NA NA NA hsa-miR-361-3p PPP2R5B 0.485361250955594 0.00074097948047418 -0.243058048013626 0.0211699067670468 MirTarget;miRNATAP -0.257798491617221 4.2719850477173e-09 NA NA NA hsa-miR-744-5p PPP2R5B 0.734924181943417 2.06706878377701e-05 -0.243058048013626 0.0211699067670468 MirTarget -0.190702304045959 1.53396062098763e-07 NA NA NA hsa-miR-107 PPP2R5C 0.85152957824299 1.22369651446858e-11 -0.314093127816279 2.92638367690439e-05 PITA;miRanda;miRNATAP -0.119876416568357 0.00082672538569924 NA NA NA hsa-miR-132-3p PPP2R5C 0.615446256559387 1.70100472454261e-06 -0.314093127816279 2.92638367690439e-05 miRNATAP -0.162957462542642 4.24279469856147e-06 NA NA NA hsa-miR-186-5p PPP2R5C 0.35512789129261 0.0196931838168008 -0.314093127816279 2.92638367690439e-05 mirMAP;miRNATAP -0.105707745748858 0.000517031529505707 NA NA NA hsa-miR-212-3p PPP2R5C 0.810640598956005 2.08058512206955e-06 -0.314093127816279 2.92638367690439e-05 miRNATAP -0.14208437827145 5.60552180296949e-08 NA NA NA hsa-miR-26a-5p PPP2R5C -0.507487084157331 3.23715933371269e-05 -0.314093127816279 2.92638367690439e-05 mirMAP -0.117700239691979 0.00197791317059992 NA NA NA hsa-miR-330-5p PPP2R5C 0.621676971901542 0.00233177378595631 -0.314093127816279 2.92638367690439e-05 miRanda -0.106914317732635 1.44704556743694e-06 NA NA NA hsa-miR-455-5p PPP2R5C 0.644390760445571 0.00262275997170695 -0.314093127816279 2.92638367690439e-05 miRanda -0.101293956575555 1.66468210314825e-06 NA NA NA hsa-let-7a-3p PPP2R5E 0.283468597868531 0.127007787220086 0.0314789634241146 0.700856748949071 mirMAP -0.152013004078688 6.40942061701976e-09 NA NA NA hsa-let-7b-3p PPP2R5E 0.377956364821509 0.0061730103051373 0.0314789634241146 0.700856748949071 mirMAP -0.13335253655319 0.000223053263719782 NA NA NA hsa-miR-101-5p PPP2R5E -0.368786665738683 0.0435281632867238 0.0314789634241146 0.700856748949071 MirTarget -0.121008895745197 7.34347841776813e-06 NA NA NA hsa-miR-125a-5p PPP2R5E -0.261743402170195 0.116107665196876 0.0314789634241146 0.700856748949071 miRNAWalker2_validate -0.115290900111095 0.000109961913685151 NA NA NA hsa-miR-126-5p PPP2R5E 0.450893496822779 0.0112966412858755 0.0314789634241146 0.700856748949071 MirTarget;mirMAP -0.132162545995022 1.57684680695321e-06 NA NA NA hsa-miR-130a-3p PPP2R5E 0.218018009582956 0.274232880676821 0.0314789634241146 0.700856748949071 mirMAP -0.111762442096547 5.93173204059191e-06 NA NA NA hsa-miR-30b-5p PPP2R5E -0.0106833209203501 0.954966272944722 0.0314789634241146 0.700856748949071 mirMAP -0.146469303582984 1.35098688754856e-08 NA NA NA hsa-miR-30c-5p PPP2R5E -0.172645077009891 0.276411433016536 0.0314789634241146 0.700856748949071 mirMAP -0.116397782860685 0.000213250793254969 NA NA NA hsa-miR-30e-3p PPP2R5E -0.444998679251398 0.000501880465265124 0.0314789634241146 0.700856748949071 MirTarget -0.165212303497102 2.0691619880076e-05 NA NA NA hsa-miR-30e-5p PPP2R5E -0.284839730810255 0.0405852891523165 0.0314789634241146 0.700856748949071 mirMAP -0.144163935567684 5.81678356434172e-05 NA NA NA hsa-miR-374a-3p PPP2R5E 0.0703956336838676 0.602396227448772 0.0314789634241146 0.700856748949071 MirTarget -0.134474500922421 0.000302651646753834 NA NA NA hsa-miR-374a-5p PPP2R5E 0.239597788731458 0.0202963000797544 0.0314789634241146 0.700856748949071 mirMAP -0.13809758813922 0.00540322372732104 NA NA NA hsa-miR-374b-5p PPP2R5E 0.00249900187478502 0.985380083859555 0.0314789634241146 0.700856748949071 mirMAP -0.188230496751383 2.32502986256914e-07 NA NA NA hsa-miR-454-3p PPP2R5E 0.823770738595667 1.30339728183332e-05 0.0314789634241146 0.700856748949071 mirMAP -0.106204556999545 3.64813371995072e-05 NA NA NA hsa-miR-590-3p PPP2R5E 0.858742926831233 0.000127281269371976 0.0314789634241146 0.700856748949071 MirTarget;PITA;miRanda;mirMAP -0.110341844526814 3.07907172330384e-07 NA NA NA hsa-let-7a-3p PRKAA1 0.283468597868531 0.127007787220086 0.317356827284011 0.00310431938627586 MirTarget;mirMAP -0.108372659231154 0.0022910713815317 NA NA NA hsa-miR-126-5p PRKAA1 0.450893496822779 0.0112966412858755 0.317356827284011 0.00310431938627586 mirMAP -0.149365733258989 4.78646370896579e-05 NA NA NA hsa-miR-130a-3p PRKAA1 0.218018009582956 0.274232880676821 0.317356827284011 0.00310431938627586 MirTarget;miRNATAP -0.177048665504691 4.87301776071391e-08 NA NA NA hsa-miR-139-5p PRKAA1 -1.41674256628297 4.51005988644234e-14 0.317356827284011 0.00310431938627586 MirTarget;miRanda -0.170808419547915 1.98295654959336e-07 NA NA NA hsa-miR-152-3p PRKAA1 -0.111001946024117 0.385698870309139 0.317356827284011 0.00310431938627586 MirTarget -0.307898425184584 1.73711134921829e-09 NA NA NA hsa-miR-195-3p PRKAA1 -0.694544351365025 0.000214711021317786 0.317356827284011 0.00310431938627586 MirTarget -0.141472731405272 4.38062291125644e-05 NA NA NA hsa-miR-195-5p PRKAA1 -1.07154705036962 4.16544134775761e-08 0.317356827284011 0.00310431938627586 MirTarget -0.21912622950092 4.80258274793383e-12 NA NA NA hsa-miR-30a-3p PRKAA1 -1.27950866170419 4.33230022379782e-09 0.317356827284011 0.00310431938627586 MirTarget;miRNATAP -0.177446896338335 4.67102318365527e-10 NA NA NA hsa-miR-30a-5p PRKAA1 -0.742755040631906 3.79943871404435e-05 0.317356827284011 0.00310431938627586 miRNAWalker2_validate -0.106124911882044 0.00333446904625933 NA NA NA hsa-miR-30e-3p PRKAA1 -0.444998679251398 0.000501880465265124 0.317356827284011 0.00310431938627586 MirTarget -0.319767236969206 2.27094934626653e-10 NA NA NA hsa-miR-374b-5p PRKAA1 0.00249900187478502 0.985380083859555 0.317356827284011 0.00310431938627586 mirMAP -0.191995555051636 8.32796159594684e-05 NA NA NA hsa-miR-495-3p PRKAA1 -0.024887553302567 0.897251687801771 0.317356827284011 0.00310431938627586 mirMAP -0.208244791063672 4.27088404472275e-10 NA NA NA hsa-miR-497-5p PRKAA1 -0.486115215577409 0.00973897247186318 0.317356827284011 0.00310431938627586 MirTarget -0.181032614400519 1.35403837120413e-07 NA NA NA hsa-miR-664a-3p PRKAA1 -0.0290482945770787 0.844010225386475 0.317356827284011 0.00310431938627586 mirMAP -0.113585059913552 0.0121585772647167 NA NA NA hsa-let-7a-3p PRKAA2 0.283468597868531 0.127007787220086 -2.4618359528533 1.10256665464061e-06 mirMAP -1.0510185531421 2.31208022227058e-10 NA NA NA hsa-let-7a-5p PRKAA2 0.298659498236324 0.00963231738125113 -2.4618359528533 1.10256665464061e-06 MirTarget;TargetScan -0.818248310530583 0.00345737050332717 NA NA NA hsa-let-7b-3p PRKAA2 0.377956364821509 0.0061730103051373 -2.4618359528533 1.10256665464061e-06 mirMAP -1.71256141666645 7.70209950413869e-15 NA NA NA hsa-let-7b-5p PRKAA2 0.16896311055967 0.160596228583843 -2.4618359528533 1.10256665464061e-06 miRNAWalker2_validate;MirTarget -0.829642082964893 0.00198747004322388 NA NA NA hsa-let-7d-5p PRKAA2 0.686819803681087 1.08347860862215e-06 -2.4618359528533 1.10256665464061e-06 MirTarget -1.97643453748726 1.00261873104639e-21 NA NA NA hsa-let-7f-1-3p PRKAA2 1.09636075438131 3.42037366931931e-10 -2.4618359528533 1.10256665464061e-06 mirMAP -1.61422396658488 1.68840299861194e-23 NA NA NA hsa-let-7f-5p PRKAA2 0.300925310468863 0.0221019558342241 -2.4618359528533 1.10256665464061e-06 MirTarget -0.915939195400768 0.00015936440116814 NA NA NA hsa-let-7g-5p PRKAA2 0.296128761926282 0.0296823495976068 -2.4618359528533 1.10256665464061e-06 MirTarget -1.91286498580308 5.10205089141883e-18 NA NA NA hsa-let-7i-5p PRKAA2 0.90895826823783 5.79676789748755e-17 -2.4618359528533 1.10256665464061e-06 MirTarget -1.89615010382439 2.27270998372864e-12 NA NA NA hsa-miR-103a-2-5p PRKAA2 0.668868218338912 0.0220512854713701 -2.4618359528533 1.10256665464061e-06 mirMAP -0.620321217477811 3.56169914368181e-07 NA NA NA hsa-miR-106a-5p PRKAA2 0.587427028487119 0.00838999163993323 -2.4618359528533 1.10256665464061e-06 mirMAP -0.385572815863293 0.00636370389385344 NA NA NA hsa-miR-106b-5p PRKAA2 1.08518388423396 4.82746923373852e-09 -2.4618359528533 1.10256665464061e-06 mirMAP -1.27828563297199 4.64498821823535e-16 NA NA NA hsa-miR-126-5p PRKAA2 0.450893496822779 0.0112966412858755 -2.4618359528533 1.10256665464061e-06 mirMAP -1.02607483480923 3.2784839378708e-09 NA NA NA hsa-miR-130b-3p PRKAA2 1.29757792612022 1.70655148591568e-06 -2.4618359528533 1.10256665464061e-06 MirTarget -0.909406663023241 2.66783760547034e-17 NA NA NA hsa-miR-141-3p PRKAA2 1.76274853293464 9.99331900755725e-07 -2.4618359528533 1.10256665464061e-06 mirMAP -0.725538899580421 9.64988725847209e-20 NA NA NA hsa-miR-142-5p PRKAA2 1.08445947321046 0.000126372881543671 -2.4618359528533 1.10256665464061e-06 mirMAP -0.837290136451086 1.10086254983473e-15 NA NA NA hsa-miR-144-3p PRKAA2 -1.37061426401952 5.85913017989725e-05 -2.4618359528533 1.10256665464061e-06 mirMAP -0.23808291257412 0.0102216542931272 NA NA NA hsa-miR-146a-5p PRKAA2 0.801543189433048 0.00411744525146003 -2.4618359528533 1.10256665464061e-06 MirTarget -0.856797220075377 7.97491495994659e-16 NA NA NA hsa-miR-146b-5p PRKAA2 2.23105707690238 3.83997814011313e-23 -2.4618359528533 1.10256665464061e-06 MirTarget -1.03034867508204 1.77551416794156e-17 NA NA NA hsa-miR-154-5p PRKAA2 0.080205508185929 0.719781991745231 -2.4618359528533 1.10256665464061e-06 mirMAP -0.379492484680835 0.00934604872070142 NA NA NA hsa-miR-15b-3p PRKAA2 0.811179945491507 0.000927520880593552 -2.4618359528533 1.10256665464061e-06 mirMAP -1.15228811462491 1.48291587533728e-22 NA NA NA hsa-miR-16-2-3p PRKAA2 0.869267463341732 0.000785361809327569 -2.4618359528533 1.10256665464061e-06 mirMAP -1.03989937989969 2.30824761236349e-20 NA NA NA hsa-miR-17-5p PRKAA2 1.57209612312313 5.10453838016207e-11 -2.4618359528533 1.10256665464061e-06 mirMAP -1.04841235869837 1.306546554684e-18 NA NA NA hsa-miR-181a-2-3p PRKAA2 0.761758815767271 3.4163207928657e-06 -2.4618359528533 1.10256665464061e-06 mirMAP -0.381569637317831 0.0462590342588811 NA NA NA hsa-miR-181a-5p PRKAA2 1.39352013383959 4.74824377258519e-17 -2.4618359528533 1.10256665464061e-06 mirMAP -1.08849992657508 4.78556858156025e-10 NA NA NA hsa-miR-181b-5p PRKAA2 1.44365471425231 6.03807007335243e-15 -2.4618359528533 1.10256665464061e-06 mirMAP -0.912403728783708 8.89246402771039e-09 NA NA NA hsa-miR-182-5p PRKAA2 1.73826081735237 5.69817940588551e-09 -2.4618359528533 1.10256665464061e-06 miRNAWalker2_validate;MirTarget;mirMAP -0.913522011123273 5.29402273040388e-22 NA NA NA hsa-miR-186-5p PRKAA2 0.35512789129261 0.0196931838168008 -2.4618359528533 1.10256665464061e-06 MirTarget -1.55054848233294 7.03677683661408e-15 NA NA NA hsa-miR-192-5p PRKAA2 2.0867723747501 3.57854249239079e-08 -2.4618359528533 1.10256665464061e-06 miRNAWalker2_validate -0.689798430456064 5.66854629636252e-20 NA NA NA hsa-miR-19a-3p PRKAA2 1.71062381299889 1.72281025366819e-11 -2.4618359528533 1.10256665464061e-06 mirMAP -0.918920676821129 4.05952352693489e-16 NA NA NA hsa-miR-19b-3p PRKAA2 0.936987029203338 9.28141970787798e-06 -2.4618359528533 1.10256665464061e-06 mirMAP -1.14078491457422 2.82726049923027e-16 NA NA NA hsa-miR-200a-3p PRKAA2 2.02394729844446 2.21240501925011e-08 -2.4618359528533 1.10256665464061e-06 mirMAP -0.717466896737305 1.00719810060195e-19 NA NA NA hsa-miR-200b-3p PRKAA2 2.06025765178663 3.07718049337497e-10 -2.4618359528533 1.10256665464061e-06 MirTarget -0.79671854651386 3.19149069649392e-20 NA NA NA hsa-miR-200c-3p PRKAA2 1.74925752003763 3.42000026705311e-08 -2.4618359528533 1.10256665464061e-06 MirTarget -0.808785589247955 3.93285390027438e-19 NA NA NA hsa-miR-203a-3p PRKAA2 0.986535065247669 0.00954714606545506 -2.4618359528533 1.10256665464061e-06 MirTarget -0.593766692882929 4.00333362287712e-14 NA NA NA hsa-miR-20a-5p PRKAA2 1.57190995476158 8.72275528729458e-12 -2.4618359528533 1.10256665464061e-06 mirMAP -0.946154906850771 5.51241645139011e-14 NA NA NA hsa-miR-21-3p PRKAA2 1.87780012411493 8.38052480155167e-17 -2.4618359528533 1.10256665464061e-06 mirMAP -1.21493682460027 9.46934851914643e-24 NA NA NA hsa-miR-22-5p PRKAA2 0.668839167786886 0.00102248931590479 -2.4618359528533 1.10256665464061e-06 mirMAP -1.03104939766582 3.95404348857962e-12 NA NA NA hsa-miR-23a-3p PRKAA2 0.694558223570443 8.99413995422816e-10 -2.4618359528533 1.10256665464061e-06 mirMAP -1.71500184831296 1.65444748646013e-10 NA NA NA hsa-miR-26a-2-3p PRKAA2 0.0619487388777404 0.765401751442771 -2.4618359528533 1.10256665464061e-06 mirMAP -0.347742056712253 0.0254653010862027 NA NA NA hsa-miR-26b-5p PRKAA2 -0.499493687076043 0.0118149973400486 -2.4618359528533 1.10256665464061e-06 mirMAP -0.6786636686035 1.64934395784752e-05 NA NA NA hsa-miR-27b-5p PRKAA2 0.339609517261996 0.0211014347102234 -2.4618359528533 1.10256665464061e-06 MirTarget;miRNATAP -0.569402505294677 0.00865547030858148 NA NA NA hsa-miR-301a-3p PRKAA2 1.22580753116505 5.84016077664577e-09 -2.4618359528533 1.10256665464061e-06 MirTarget -0.927072248829749 5.16183284405069e-11 NA NA NA hsa-miR-30b-5p PRKAA2 -0.0106833209203501 0.954966272944722 -2.4618359528533 1.10256665464061e-06 MirTarget -0.472284530665215 0.00496113583654359 NA NA NA hsa-miR-30d-3p PRKAA2 0.0608340295673737 0.708110230223927 -2.4618359528533 1.10256665464061e-06 MirTarget;miRNATAP -0.777162462619164 6.80810571773578e-05 NA NA NA hsa-miR-30d-5p PRKAA2 0.26829866064717 0.0228954180095085 -2.4618359528533 1.10256665464061e-06 MirTarget -1.01085871541923 0.000206825677149437 NA NA NA hsa-miR-30e-5p PRKAA2 -0.284839730810255 0.0405852891523165 -2.4618359528533 1.10256665464061e-06 MirTarget -1.2055850432979 9.36180374652699e-08 NA NA NA hsa-miR-323a-3p PRKAA2 0.308398343176418 0.29758426681013 -2.4618359528533 1.10256665464061e-06 mirMAP -0.546756029044216 7.66830647756708e-07 NA NA NA hsa-miR-330-3p PRKAA2 0.391166748754241 0.0581284813543685 -2.4618359528533 1.10256665464061e-06 MirTarget -0.744235401416832 1.92301289928998e-06 NA NA NA hsa-miR-331-3p PRKAA2 0.818192524829557 0.000359485856225569 -2.4618359528533 1.10256665464061e-06 MirTarget -0.84768414229636 1.47587652267115e-10 NA NA NA hsa-miR-335-3p PRKAA2 2.29463721765513 4.1956113745077e-18 -2.4618359528533 1.10256665464061e-06 MirTarget -0.834623629449378 3.40669285115076e-15 NA NA NA hsa-miR-335-5p PRKAA2 0.576542642348884 0.01886326850059 -2.4618359528533 1.10256665464061e-06 MirTarget;miRNATAP -0.464477977570563 0.000287740264934404 NA NA NA hsa-miR-338-5p PRKAA2 -0.420442436641152 0.0583175290447746 -2.4618359528533 1.10256665464061e-06 mirMAP -0.381323740897257 0.00750326929532797 NA NA NA hsa-miR-33a-3p PRKAA2 0.21453033253985 0.371591474252951 -2.4618359528533 1.10256665464061e-06 mirMAP -0.778728699333921 6.98093288582364e-09 NA NA NA hsa-miR-342-3p PRKAA2 0.235422340773149 0.290471946350276 -2.4618359528533 1.10256665464061e-06 PITA -0.474504330728275 0.000810910626072557 NA NA NA hsa-miR-34a-5p PRKAA2 0.691825068787607 0.00069818668499891 -2.4618359528533 1.10256665464061e-06 miRNATAP -1.32575786392927 2.07368424911612e-20 NA NA NA hsa-miR-369-3p PRKAA2 0.644921905467686 0.00104986428608648 -2.4618359528533 1.10256665464061e-06 mirMAP -0.596972657421793 0.000182837389212258 NA NA NA hsa-miR-382-5p PRKAA2 1.06857390832162 1.26589966030711e-09 -2.4618359528533 1.10256665464061e-06 mirMAP -0.595594129312405 0.000629698845216889 NA NA NA hsa-miR-409-3p PRKAA2 1.02296003511803 1.54748197930307e-08 -2.4618359528533 1.10256665464061e-06 mirMAP -0.861405879879973 2.87150509770149e-07 NA NA NA hsa-miR-421 PRKAA2 1.26653675546617 2.35180826009926e-08 -2.4618359528533 1.10256665464061e-06 MirTarget;PITA;mirMAP;miRNATAP -0.533860039824715 8.74205394225865e-05 NA NA NA hsa-miR-429 PRKAA2 1.58250682050303 4.75828087352234e-05 -2.4618359528533 1.10256665464061e-06 MirTarget;miRNATAP -0.648402561497074 1.80757075123841e-17 NA NA NA hsa-miR-454-3p PRKAA2 0.823770738595667 1.30339728183332e-05 -2.4618359528533 1.10256665464061e-06 MirTarget -1.11717303955664 2.12711885631698e-12 NA NA NA hsa-miR-500a-5p PRKAA2 1.33126717816499 3.1497328652235e-07 -2.4618359528533 1.10256665464061e-06 mirMAP -0.961478063704849 6.06620437992175e-18 NA NA NA hsa-miR-539-5p PRKAA2 0.455406484803261 0.10846447950775 -2.4618359528533 1.10256665464061e-06 mirMAP -0.469104184475009 2.79606557011932e-05 NA NA NA hsa-miR-576-5p PRKAA2 0.872721964495849 5.20470410008775e-05 -2.4618359528533 1.10256665464061e-06 mirMAP -1.26088160499835 6.62332748149022e-21 NA NA NA hsa-miR-577 PRKAA2 0.615893340074725 0.210494450869356 -2.4618359528533 1.10256665464061e-06 MirTarget;PITA;miRNATAP -0.395759145827277 6.22754185488656e-09 NA NA NA hsa-miR-582-5p PRKAA2 0.0720675907490005 0.728284850619144 -2.4618359528533 1.10256665464061e-06 mirMAP -0.656875893506494 1.42934863212595e-05 NA NA NA hsa-miR-589-5p PRKAA2 1.20000320800112 1.34209467040505e-13 -2.4618359528533 1.10256665464061e-06 MirTarget -1.57544920998029 2.06853931928923e-19 NA NA NA hsa-miR-590-3p PRKAA2 0.858742926831233 0.000127281269371976 -2.4618359528533 1.10256665464061e-06 mirMAP;miRNATAP -1.15277580726638 1.3704598615018e-18 NA NA NA hsa-miR-655-3p PRKAA2 0.67732584679256 0.00227742589637843 -2.4618359528533 1.10256665464061e-06 MirTarget -0.337849800281926 0.0224789741268304 NA NA NA hsa-miR-7-1-3p PRKAA2 0.94398354303717 7.5771319809992e-05 -2.4618359528533 1.10256665464061e-06 MirTarget;mirMAP -1.20206408170562 1.3927809823232e-23 NA NA NA hsa-miR-93-5p PRKAA2 1.68243825551104 4.62947431501061e-15 -2.4618359528533 1.10256665464061e-06 mirMAP -1.01598751666067 2.28744358711252e-14 NA NA NA hsa-miR-96-5p PRKAA2 1.44821155854693 6.56312590328933e-06 -2.4618359528533 1.10256665464061e-06 TargetScan -0.851634972563289 9.03514047644064e-19 NA NA NA hsa-miR-98-5p PRKAA2 0.72508924193932 6.07191196761022e-10 -2.4618359528533 1.10256665464061e-06 miRNAWalker2_validate;MirTarget -1.64572361676651 2.10371695755686e-10 NA NA NA hsa-miR-130b-5p PRKCA 1.47709791778827 1.34679413565661e-06 0.011989547805439 0.942502741250812 mirMAP -0.171429439352642 1.11587242779179e-07 NA NA NA hsa-miR-142-5p PRKCA 1.08445947321046 0.000126372881543671 0.011989547805439 0.942502741250812 mirMAP -0.201699348683102 4.90622211911232e-09 NA NA NA hsa-miR-146a-5p PRKCA 0.801543189433048 0.00411744525146003 0.011989547805439 0.942502741250812 mirMAP -0.134655117045737 0.000168655004061988 NA NA NA hsa-miR-146b-5p PRKCA 2.23105707690238 3.83997814011313e-23 0.011989547805439 0.942502741250812 mirMAP -0.153446820240124 0.000184746526922487 NA NA NA hsa-miR-150-5p PRKCA 0.391701745753361 0.166399987744223 0.011989547805439 0.942502741250812 mirMAP -0.11417009540347 0.00136937649658156 NA NA NA hsa-miR-17-3p PRKCA 1.37838995268509 5.00444740462873e-13 0.011989547805439 0.942502741250812 miRNAWalker2_validate -0.147001861502741 0.00389289286055175 NA NA NA hsa-miR-181a-5p PRKCA 1.39352013383959 4.74824377258519e-17 0.011989547805439 0.942502741250812 mirMAP -0.154420913800487 0.0075638434939541 NA NA NA hsa-miR-181b-5p PRKCA 1.44365471425231 6.03807007335243e-15 0.011989547805439 0.942502741250812 mirMAP -0.174977550140736 0.000762630434910308 NA NA NA hsa-miR-183-5p PRKCA 2.08412478942637 1.08931431254487e-10 0.011989547805439 0.942502741250812 miRNATAP -0.164389215726407 2.54415883337075e-08 NA NA NA hsa-miR-186-5p PRKCA 0.35512789129261 0.0196931838168008 0.011989547805439 0.942502741250812 miRNATAP -0.221697868181595 0.000931727846842534 NA NA NA hsa-miR-193b-3p PRKCA -0.0325435210716751 0.883410452152887 0.011989547805439 0.942502741250812 miRNAWalker2_validate -0.193110122301387 2.10396201485406e-05 NA NA NA hsa-miR-193b-5p PRKCA -0.285781399446643 0.232222694151592 0.011989547805439 0.942502741250812 mirMAP -0.169015187187549 6.14294801577059e-05 NA NA NA hsa-miR-1976 PRKCA 0.888680419203938 2.16642020734521e-05 0.011989547805439 0.942502741250812 miRNATAP -0.157226968706441 0.00171083118695891 NA NA NA hsa-miR-19b-1-5p PRKCA 1.78323584062047 7.55784857614623e-15 0.011989547805439 0.942502741250812 mirMAP -0.13376908140152 0.001378722474083 NA NA NA hsa-miR-200b-3p PRKCA 2.06025765178663 3.07718049337497e-10 0.011989547805439 0.942502741250812 TargetScan -0.108241426571207 0.000262578924015237 NA NA NA hsa-miR-200c-3p PRKCA 1.74925752003763 3.42000026705311e-08 0.011989547805439 0.942502741250812 miRNATAP -0.143387067513447 2.87423908201966e-06 NA NA NA hsa-miR-22-5p PRKCA 0.668839167786886 0.00102248931590479 0.011989547805439 0.942502741250812 mirMAP -0.177396983928844 0.00031979687771852 NA NA NA hsa-miR-2355-3p PRKCA 0.101789577163865 0.693158423682028 0.011989547805439 0.942502741250812 mirMAP -0.138975286803926 0.000678989115010752 NA NA NA hsa-miR-29a-5p PRKCA 1.00715634051951 4.47499137997344e-07 0.011989547805439 0.942502741250812 mirMAP -0.178440639441324 0.000325239329279153 NA NA NA hsa-miR-30e-3p PRKCA -0.444998679251398 0.000501880465265124 0.011989547805439 0.942502741250812 mirMAP -0.180113558224167 0.0249887788929294 NA NA NA hsa-miR-330-3p PRKCA 0.391166748754241 0.0581284813543685 0.011989547805439 0.942502741250812 mirMAP -0.224482956128231 8.11117341984718e-06 NA NA NA hsa-miR-340-5p PRKCA 0.344103676703511 0.0160638942614091 0.011989547805439 0.942502741250812 mirMAP -0.306877665867527 1.54416013145896e-05 NA NA NA hsa-miR-369-3p PRKCA 0.644921905467686 0.00104986428608648 0.011989547805439 0.942502741250812 PITA;miRNATAP -0.20304365386022 7.15872061032479e-05 NA NA NA hsa-miR-374a-3p PRKCA 0.0703956336838676 0.602396227448772 0.011989547805439 0.942502741250812 mirMAP -0.22267485671183 0.00358132021754311 NA NA NA hsa-miR-374a-5p PRKCA 0.239597788731458 0.0202963000797544 0.011989547805439 0.942502741250812 mirMAP -0.45703847123366 5.16876833886692e-06 NA NA NA hsa-miR-374b-5p PRKCA 0.00249900187478502 0.985380083859555 0.011989547805439 0.942502741250812 mirMAP -0.168663297071887 0.026440933551222 NA NA NA hsa-miR-429 PRKCA 1.58250682050303 4.75828087352234e-05 0.011989547805439 0.942502741250812 miRanda;miRNATAP -0.101163619888014 8.80289322659118e-05 NA NA NA hsa-miR-450b-5p PRKCA 1.36137774989901 7.45499130609203e-11 0.011989547805439 0.942502741250812 PITA;mirMAP;miRNATAP -0.124627316291886 0.00781299413580925 NA NA NA hsa-miR-452-5p PRKCA 0.612108901803716 0.0110020550949664 0.011989547805439 0.942502741250812 mirMAP -0.105992840145472 0.0116170722415173 NA NA NA hsa-miR-495-3p PRKCA -0.024887553302567 0.897251687801771 0.011989547805439 0.942502741250812 mirMAP -0.105797660090786 0.0464974022121671 NA NA NA hsa-miR-505-3p PRKCA 0.68973424635459 0.00225185811813183 0.011989547805439 0.942502741250812 miRNAWalker2_validate -0.163001973704478 0.000242217094394213 NA NA NA hsa-miR-550a-3p PRKCA 0.691643089167284 0.0329454607437103 0.011989547805439 0.942502741250812 miRNATAP -0.131602303065082 0.000180638909544589 NA NA NA hsa-miR-590-3p PRKCA 0.858742926831233 0.000127281269371976 0.011989547805439 0.942502741250812 PITA;miRanda;mirMAP;miRNATAP -0.249847263946731 1.19260552473751e-08 NA NA NA hsa-miR-654-3p PRKCA -0.141140644392039 0.545807044192286 0.011989547805439 0.942502741250812 mirMAP -0.124205811492343 0.00427402321719794 NA NA NA hsa-miR-92a-3p PRKCA 1.06124545165614 6.51550014372282e-08 0.011989547805439 0.942502741250812 miRNAWalker2_validate -0.105794669496435 0.0368971322526323 NA NA NA hsa-miR-93-3p PRKCA 1.18510939268904 1.19856269043125e-06 0.011989547805439 0.942502741250812 mirMAP -0.101897966213245 0.012438491699105 NA NA NA hsa-let-7i-5p PRLR 0.90895826823783 5.79676789748755e-17 -0.629730773551203 0.124677603017314 miRNATAP -0.719626798204293 0.00124532299386843 NA NA NA hsa-miR-181a-5p PRLR 1.39352013383959 4.74824377258519e-17 -0.629730773551203 0.124677603017314 miRNAWalker2_validate;miRNATAP -0.416173856844257 0.00363184428620485 NA NA NA hsa-miR-181b-5p PRLR 1.44365471425231 6.03807007335243e-15 -0.629730773551203 0.124677603017314 miRNATAP -0.359263509947859 0.00544584179227511 NA NA NA hsa-let-7a-3p PTEN 0.283468597868531 0.127007787220086 -0.187156334149252 0.0774777059361541 mirMAP -0.146036865570309 2.47608035669665e-05 NA NA NA hsa-let-7b-3p PTEN 0.377956364821509 0.0061730103051373 -0.187156334149252 0.0774777059361541 mirMAP -0.140452087111016 0.00297615522145834 NA NA NA hsa-let-7f-1-3p PTEN 1.09636075438131 3.42037366931931e-10 -0.187156334149252 0.0774777059361541 mirMAP -0.110568855525199 0.00207851466529083 NA NA NA hsa-miR-106b-5p PTEN 1.08518388423396 4.82746923373852e-09 -0.187156334149252 0.0774777059361541 miRNAWalker2_validate;miRTarBase;miRNATAP -0.16345456792223 1.04711472843117e-06 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-130a-3p PTEN 0.218018009582956 0.274232880676821 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.101878654607976 0.00170991786486828 24490491;27062783;22614869;26837847;27040383;27035216;26043084 Down-regulated miR-130a did not affect cell proliferations but enhanced the sensitivity of the cells to cisplatin inhibited the expressions of MDR1 mRNA and P-gp and increased the expression of PTEN proteins; MiR-130a inhibitor can reverse the cisplatin resistance by upregulating the expression of PTEN proteins and down-regulating P-gp in A2780 cell lines;Platinum-resistant patients had significantly higher levels of expression of miR-130a and BCL-2 and lower level of PTEN than platinum-sensitive patients P < 0.05; MiR-130a may mediate the generation of platinum resistance in epithelial ovarian cancer through inhibiting PTEN to activate PI3K/AKT signaling pathway and increasing BCL-2 to inhibit tumor cell apoptosis;We found that miR-130a was upregulated in SKOV3/CIS compared to the parental SKOV3 cells and PTEN was predicted to be the potential target of miR-130a;The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;In addition by targeting PTEN 3' untranslated region miR-130a might increase cell growth and initiate protein kinase B AKT pathway activation;MicroRNA 130a promotes the metastasis and epithelial mesenchymal transition of osteosarcoma by targeting PTEN; MiR-130a exerted promoting effects on metastatic behavior and EMT of osteosarcoma cells through suppressing PTEN expression;This role of miR-130a may be achieved by regulating the MDR1 and PTEN gene expression drug resistance;drug resistance;;cell migration;;metastasis; ovarian cancer;ovarian cancer;ovarian cancer;bladder cancer;cervical and endocervical cancer;sarcoma;ovarian cancer hsa-miR-130b-3p PTEN 1.29757792612022 1.70655148591568e-06 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.134458037859614 3.36188015580824e-09 26837847;25637514 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC cell migration; bladder cancer;esophageal cancer hsa-miR-148a-3p PTEN -0.18108394434325 0.495345303586758 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.146210523100702 6.24373619920313e-10 22496917 Introduction of anti-miR-148a increased PTEN protein and mRNA expression suggesting that PTEN was targeted by miR-148a liver cancer hsa-miR-148b-3p PTEN 0.719517328390822 3.51245964668412e-05 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.194606896503993 7.38160514589378e-08 NA NA NA hsa-miR-15b-3p PTEN 0.811179945491507 0.000927520880593552 -0.187156334149252 0.0774777059361541 mirMAP -0.139710816683617 4.9085359801407e-08 NA NA NA hsa-miR-16-2-3p PTEN 0.869267463341732 0.000785361809327569 -0.187156334149252 0.0774777059361541 mirMAP -0.119658150400376 8.79650090092113e-07 NA NA NA hsa-miR-17-5p PTEN 1.57209612312313 5.10453838016207e-11 -0.187156334149252 0.0774777059361541 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.107223017801684 3.12017381951387e-05 27400681;23391506;23133552;26629823;24462867;26318586;26215320;25634356;26500892;24912422;23418359 GFRα2 prompts cell growth and chemoresistance through down regulating tumor suppressor gene PTEN via Mir 17 5p in pancreatic cancer; Mechanically we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level;We found that these phenotypes were the results of miR-17 targeting PTEN;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;We hypothesized that knocking down the oncogenic microRNA oncomiR miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor proteins illustrating a route to oligonucleotide therapy of TNBC; Contrary to conventional wisdom antisense knockdown of oncomiR miR-17-5p guide strand reduced PDCD4 and PTEN proteins by 1.8±0.3 fold in human TNBC cells instead of raising them; Bioinformatics analysis and folding energy calculations revealed that mRNA targets of miR-17-5p guide strand such as PDCD4 and PTEN could also be regulated by miR-17-3p passenger strand;miR 17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression; Expression of miR-17 was negatively correlated with PTEN in OS tissues;Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR 17 family in prostate cancer; Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo;In addition ERβ expression significantly increased in calycosin-treated HCT-116 cells followed by a decrease of miR-17 and up-regulation of PTEN; Our results indicate that calycosin has an inhibitory effect on CRC which might be obtained by ERβ-mediated regulation of miR-17 and PTEN expression;The High Expression of the microRNA 17 92 Cluster and its Paralogs and the Downregulation of the Target Gene PTEN Is Associated with Primary Cutaneous B Cell Lymphoma Progression;MicroRNA 17 5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling; miR-17-5p activates AKT by downregulation of PTEN in ovarian cancer cells;MicroRNA 17 5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression; We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance; Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance; MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;The mature miR-17-5p exerted this function by repressing the expression of PTEN drug resistance;;;;metastasis;;;progression;drug resistance;metastasis;drug resistance;poor survival; pancreatic cancer;glioblastoma;sarcoma;breast cancer;sarcoma;prostate cancer;colorectal cancer;B cell lymphoma;ovarian cancer;colorectal cancer;liver cancer hsa-miR-186-5p PTEN 0.35512789129261 0.0196931838168008 -0.187156334149252 0.0774777059361541 mirMAP;miRNATAP -0.213266547594836 4.02773910516678e-07 NA NA NA hsa-miR-188-5p PTEN 1.57437249320621 2.78824007819973e-08 -0.187156334149252 0.0774777059361541 MirTarget;PITA;miRNATAP -0.106744558901329 3.53640753468927e-06 NA NA NA hsa-miR-18a-5p PTEN 2.04701000113742 1.30593450319289e-12 -0.187156334149252 0.0774777059361541 miRNAWalker2_validate;miRTarBase -0.100748931792874 1.71536361157568e-06 24681249;27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis metastasis; colon cancer;esophageal cancer hsa-miR-193a-3p PTEN 0.148284355948959 0.379093889907371 -0.187156334149252 0.0774777059361541 PITA;miRanda -0.114092937728856 0.00316154947636919 26753960;23223432 Downregulation of microRNA 193 3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene;Our study identifies miR-193a and PTEN as targets for AML1/ETO and provides evidence that links the epigenetic silencing of tumor suppressor genes miR-193a and PTEN to differentiation block of myeloid precursors drug resistance;differentiation gastric cancer;acute myeloid leukemia hsa-miR-19b-3p PTEN 0.936987029203338 9.28141970787798e-06 -0.187156334149252 0.0774777059361541 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.132184212596985 9.17498922317951e-06 26098000;24831732;21853360;24681249 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN ;;drug resistance;metastasis lung cancer;breast cancer;breast cancer;colon cancer hsa-miR-25-3p PTEN 0.948739680210032 3.62304579611938e-09 -0.187156334149252 0.0774777059361541 miRTarBase;MirTarget;miRNATAP -0.178652318021824 4.2370489398595e-06 NA NA NA hsa-miR-26b-5p PTEN -0.499493687076043 0.0118149973400486 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.125378744269599 0.000105346199903683 26068649 Down regulation of microRNA 26b modulates non small cell lung cancer cells chemoresistance and migration through the association of PTEN; It indicates that miR-26b may regulate NSCLC migration and chemosensitivity through the regulation of PTEN drug resistance lung squamous cell cancer hsa-miR-301a-3p PTEN 1.22580753116505 5.84016077664577e-09 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.122199653496651 3.6327204236196e-05 24315818;26846737 Upregulated microRNA 301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β catenin signaling; Furthermore miR-301a directly targeted and suppressed PTEN one negative regulator of the Wnt/β-catenin signaling cascade; These results demonstrate that miR-301a maintains constitutively activated Wnt/β-catenin signaling by directly targeting PTEN which promotes breast cancer invasion and metastasis;MicroRNA 301a promotes cell proliferation via PTEN targeting in Ewing's sarcoma cells; Our results demonstrated the novel mechanism controlling PTEN expression via miR-301a in ES cells metastasis; breast cancer;sarcoma hsa-miR-30e-5p PTEN -0.284839730810255 0.0405852891523165 -0.187156334149252 0.0774777059361541 mirMAP -0.114747389715699 0.0150166664385482 NA NA NA hsa-miR-32-5p PTEN 0.425717775201634 0.0402079308210921 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.152764455120355 6.27851764346309e-07 24123284;25647261;23617834 In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC; The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction; The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed; Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues; An inverse relationship between miR-32 and PTEN protein expression was identified; MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR 32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN; Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway; Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment;MicroRNA 32 miR 32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells; In this study we identified the potential effects of miR-32 on some important biological properties of CRC cells and clarified the regulation of PTEN by miR-32; The 3'-untranslated region 3'-UTR of PTEN combined with miR-32 was verified by dual-luciferase reporter assay; Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level; However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein; In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN; Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN ;;tumorigenesis colorectal cancer;liver cancer;colorectal cancer hsa-miR-320b PTEN 1.21733873788625 7.99882585998487e-07 -0.187156334149252 0.0774777059361541 MirTarget;PITA;miRanda;miRNATAP -0.12161427323368 1.49456358558295e-06 NA NA NA hsa-miR-3613-5p PTEN 1.03938524872813 2.63575941507995e-05 -0.187156334149252 0.0774777059361541 miRNATAP -0.140518853170061 2.55621656914988e-08 NA NA NA hsa-miR-374a-5p PTEN 0.239597788731458 0.0202963000797544 -0.187156334149252 0.0774777059361541 MirTarget;mirMAP -0.130082387021284 0.04507299232959 NA NA NA hsa-miR-374b-5p PTEN 0.00249900187478502 0.985380083859555 -0.187156334149252 0.0774777059361541 MirTarget;mirMAP;miRNATAP -0.156343467036307 0.00116859966891842 NA NA NA hsa-miR-421 PTEN 1.26653675546617 2.35180826009926e-08 -0.187156334149252 0.0774777059361541 miRanda -0.104669444589397 0.000172701511747581 NA NA NA hsa-miR-425-5p PTEN 0.865319550452351 0.000902803064763851 -0.187156334149252 0.0774777059361541 miRNATAP -0.107180900918189 1.00947350170994e-05 25154996 An increase in miR-425 depended upon IL-1β-induced NF-kappaB activation.Repression of PTEN by miR-425 promoted gastric cancer cell proliferation gastric cancer hsa-miR-454-3p PTEN 0.823770738595667 1.30339728183332e-05 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.152393297815498 5.04993881728631e-06 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-484 PTEN 0.401753773460753 0.0490851523101605 -0.187156334149252 0.0774777059361541 miRNATAP -0.128790875865172 4.14933898439673e-05 NA NA NA hsa-miR-590-3p PTEN 0.858742926831233 0.000127281269371976 -0.187156334149252 0.0774777059361541 MirTarget;PITA;miRanda;mirMAP -0.151818853940952 5.93029314150585e-08 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting; miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation liver cancer hsa-miR-590-5p PTEN 0.932604531809045 8.39043954167884e-05 -0.187156334149252 0.0774777059361541 mirMAP -0.135932396824307 2.90878704424935e-07 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting liver cancer hsa-miR-7-1-3p PTEN 0.94398354303717 7.5771319809992e-05 -0.187156334149252 0.0774777059361541 mirMAP -0.137152983491268 1.75733109350449e-07 NA NA NA hsa-miR-744-3p PTEN 0.704156170726514 0.016011687012928 -0.187156334149252 0.0774777059361541 miRNATAP -0.112459867347004 2.90217921888435e-07 NA NA NA hsa-miR-92a-3p PTEN 1.06124545165614 6.51550014372282e-08 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.138549364874388 1.36889903875543e-05 26432332;25515201;24137349;23546593;23133552;24026406 Downregulation of PTEN could mimic the same effects of miR-92a mimic in NSCLC cells and rescue the effects on NSCLC cells induced by miR-92a inhibitor; Taken together these findings suggested that miR-92a could promote growth metastasis and chemoresistance in NSCLC cells at least partially by targeting PTEN;MiR 92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN Mediated PI3K/AKT Pathway; The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; In addition there was a negative correlation between levels of miR-92a and the PTEN gene p < 0.0001; The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;The expression levels of miR-92a and phosphatase and tensin homologue PTEN were detected by qRT-PCR and western blot; In addition the regulation of PTEN by miR-92a was evaluated by qRT-PCR western blot and luciferase reporter assays; There was an inverse correlation between the levels of miR-92a and PTEN in CRC tissues; The overexpression of miR-92a in CRC cells decreased PTEN expression at the translational level and decreased PTEN-driven luciferase-reporter activity; Our results demonstrated that miR-92a induced EMT and regulated cell growth migration and invasion in the SW480 cells at least partially via suppression of PTEN expression metastasis;drug resistance;metastasis;cell migration;;worse prognosis;; lung squamous cell cancer;colorectal cancer;cervical and endocervical cancer;liver cancer;sarcoma;colorectal cancer hsa-miR-92b-3p PTEN 1.10163066523605 4.43024463410466e-10 -0.187156334149252 0.0774777059361541 MirTarget;miRNATAP -0.138633048696648 8.66595811770893e-05 24099768;26878388;24137349;23546593 MiR 92b regulates the cell growth cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN; Furthermore we found miR-92b could directly target PTEN a unique tumor suppressor gene which was downregulated in lung cancer tissues compared to the matched adjacent normal tissues;We revealed that patients exhibiting an upregulation of hsa-miR-92b and patients with deletions of PTEN did not tend to overlap and hsa-miR-92b and PTEN coordinately regulated the pathway of 'cell cycle' and so on;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC ;;;worse prognosis lung squamous cell cancer;breast cancer;cervical and endocervical cancer;liver cancer hsa-miR-139-5p PTK2 -1.41674256628297 4.51005988644234e-14 0.441307761445015 9.00067669291491e-07 miRanda -0.125392996755125 7.56824385023646e-06 NA NA NA hsa-miR-101-3p RAC1 -0.0683272309939689 0.544163124741916 0.078788378074405 0.392340741686174 miRNAWalker2_validate;MirTarget -0.122714106193022 0.0166720274242453 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-146b-3p RAF1 2.08650140817622 5.3293570720033e-22 -0.44281915065078 1.6619263967657e-11 MirTarget;PITA;miRNATAP -0.101453721067746 3.29913513582506e-09 NA NA NA hsa-miR-106b-5p RBL2 1.08518388423396 4.82746923373852e-09 -0.281923008753179 0.0025386513501511 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218914216379717 2.28081773738246e-14 NA NA NA hsa-miR-107 RBL2 0.85152957824299 1.22369651446858e-11 -0.281923008753179 0.0025386513501511 miRanda -0.153779671526079 0.000526538453491591 NA NA NA hsa-miR-126-5p RBL2 0.450893496822779 0.0112966412858755 -0.281923008753179 0.0025386513501511 MirTarget -0.20048469962559 1.2884420931613e-10 NA NA NA hsa-miR-140-5p RBL2 0.132398579631585 0.457960134430787 -0.281923008753179 0.0025386513501511 miRanda -0.188470743759536 2.05536931260506e-09 NA NA NA hsa-miR-142-5p RBL2 1.08445947321046 0.000126372881543671 -0.281923008753179 0.0025386513501511 PITA -0.112077298435917 8.25146121027264e-09 NA NA NA hsa-miR-17-5p RBL2 1.57209612312313 5.10453838016207e-11 -0.281923008753179 0.0025386513501511 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.140611586537728 2.86701531516767e-10 NA NA NA hsa-miR-23a-3p RBL2 0.694558223570443 8.99413995422816e-10 -0.281923008753179 0.0025386513501511 MirTarget -0.145701512603368 0.00359776963597081 NA NA NA hsa-miR-26a-2-3p RBL2 0.0619487388777404 0.765401751442771 -0.281923008753179 0.0025386513501511 MirTarget -0.120570364856211 1.43348621582053e-05 NA NA NA hsa-miR-335-3p RBL2 2.29463721765513 4.1956113745077e-18 -0.281923008753179 0.0025386513501511 MirTarget -0.101333197845206 3.17736538992929e-07 NA NA NA hsa-miR-335-5p RBL2 0.576542642348884 0.01886326850059 -0.281923008753179 0.0025386513501511 miRNAWalker2_validate -0.147435330318003 6.08888636084796e-11 NA NA NA hsa-miR-421 RBL2 1.26653675546617 2.35180826009926e-08 -0.281923008753179 0.0025386513501511 miRanda -0.114139968567765 3.09461688719248e-06 NA NA NA hsa-miR-576-5p RBL2 0.872721964495849 5.20470410008775e-05 -0.281923008753179 0.0025386513501511 MirTarget;PITA -0.171721516819629 1.0649270537075e-11 NA NA NA hsa-miR-590-3p RBL2 0.858742926831233 0.000127281269371976 -0.281923008753179 0.0025386513501511 miRanda -0.142287120989253 8.16068729560111e-09 NA NA NA hsa-miR-629-3p RBL2 0.597278340934362 0.0508108703940013 -0.281923008753179 0.0025386513501511 MirTarget -0.122313481343175 2.54995878640829e-10 NA NA NA hsa-miR-107 RELN 0.85152957824299 1.22369651446858e-11 -2.4032593050865 9.46041009197227e-10 miRanda -1.49013015149959 4.81959824581999e-16 NA NA NA hsa-miR-128-3p RELN 0.835320684237761 1.85756253116961e-09 -2.4032593050865 9.46041009197227e-10 miRNAWalker2_validate;miRTarBase;MirTarget -1.16373855149831 6.75448001784834e-12 NA NA NA hsa-miR-142-3p RELN 1.80134804047727 3.87649742898476e-07 -2.4032593050865 9.46041009197227e-10 miRanda -0.342222668961107 3.35799530055811e-07 NA NA NA hsa-miR-15a-5p RELN 1.07800995489566 4.32072598796529e-10 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -1.18583935534195 1.20142322121952e-19 NA NA NA hsa-miR-15b-5p RELN 0.637819606405168 0.000580041575431604 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -1.05188922761094 7.64307995145806e-17 NA NA NA hsa-miR-16-5p RELN 0.468459442059375 0.02635007201346 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -0.791658012633644 2.95909625213297e-12 NA NA NA hsa-miR-200b-3p RELN 2.06025765178663 3.07718049337497e-10 -2.4032593050865 9.46041009197227e-10 MirTarget;TargetScan -0.634831068527533 9.16409051000065e-21 NA NA NA hsa-miR-200c-3p RELN 1.74925752003763 3.42000026705311e-08 -2.4032593050865 9.46041009197227e-10 MirTarget -0.684171081324147 2.1427551514084e-22 NA NA NA hsa-miR-224-5p RELN 1.11923763019015 0.000974728485303372 -2.4032593050865 9.46041009197227e-10 MirTarget -0.338891099096344 2.05619846390398e-06 NA NA NA hsa-miR-27a-3p RELN 0.523219911315699 0.000116410279757859 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -1.24614295502402 1.89706649813939e-12 NA NA NA hsa-miR-27a-5p RELN 0.59763448976729 0.00736257811879899 -2.4032593050865 9.46041009197227e-10 miRNATAP -0.511415534722828 3.10440282402043e-06 NA NA NA hsa-miR-331-5p RELN 0.703863188605486 4.25406757208802e-05 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -0.725533969213365 3.12456055387076e-07 NA NA NA hsa-miR-34a-5p RELN 0.691825068787607 0.00069818668499891 -2.4032593050865 9.46041009197227e-10 miRNATAP -0.904051888129 4.29719835383996e-15 NA NA NA hsa-miR-361-5p RELN 0.538048008019709 1.61165802415302e-07 -2.4032593050865 9.46041009197227e-10 MirTarget;PITA;miRanda -0.879476604937532 0.000307180000139906 NA NA NA hsa-miR-421 RELN 1.26653675546617 2.35180826009926e-08 -2.4032593050865 9.46041009197227e-10 miRanda -0.641392110080587 9.85564560044413e-10 NA NA NA hsa-miR-424-5p RELN 0.956135912596328 0.00035164943928494 -2.4032593050865 9.46041009197227e-10 MirTarget;miRNATAP -0.466110207122208 2.41383396901586e-07 NA NA NA hsa-miR-429 RELN 1.58250682050303 4.75828087352234e-05 -2.4032593050865 9.46041009197227e-10 MirTarget;PITA;miRanda;miRNATAP -0.489135825610656 5.45537285760845e-16 NA NA NA hsa-miR-452-5p RELN 0.612108901803716 0.0110020550949664 -2.4032593050865 9.46041009197227e-10 MirTarget -0.274170777407531 0.00772802747425547 NA NA NA hsa-miR-455-3p RELN 1.12209231899143 0.00131487017648489 -2.4032593050865 9.46041009197227e-10 PITA -0.491655570375237 3.08125231610016e-13 NA NA NA hsa-miR-582-5p RELN 0.0720675907490005 0.728284850619144 -2.4032593050865 9.46041009197227e-10 MirTarget;PITA -0.450327811743994 0.000168337299452477 NA NA NA hsa-miR-589-3p RELN 1.00357906465313 8.20399071001461e-05 -2.4032593050865 9.46041009197227e-10 MirTarget -0.81652207807731 1.44758864598569e-17 NA NA NA hsa-miR-590-3p RELN 0.858742926831233 0.000127281269371976 -2.4032593050865 9.46041009197227e-10 miRanda;miRNATAP -0.788142071225478 6.58816010744757e-14 NA NA NA hsa-miR-935 RELN 2.321600496365 1.00042201726114e-07 -2.4032593050865 9.46041009197227e-10 MirTarget;PITA;miRNATAP -0.44678689874642 8.51253935635646e-16 NA NA NA hsa-miR-126-5p RPS6KB1 0.450893496822779 0.0112966412858755 0.133696512456113 0.119044963514929 mirMAP -0.158761684033751 3.1694290336535e-08 NA NA NA hsa-miR-130a-3p RPS6KB1 0.218018009582956 0.274232880676821 0.133696512456113 0.119044963514929 miRNATAP -0.109942828100862 2.31073736771455e-05 NA NA NA hsa-miR-218-5p RPS6KB1 -0.615157868107884 0.00447149109697709 0.133696512456113 0.119044963514929 miRNATAP -0.113153586442419 1.67564981720349e-06 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-2355-3p RPS6KB1 0.101789577163865 0.693158423682028 0.133696512456113 0.119044963514929 MirTarget;miRNATAP -0.102272128651898 8.26522103662318e-07 NA NA NA hsa-miR-27a-3p RPS6KB1 0.523219911315699 0.000116410279757859 0.133696512456113 0.119044963514929 MirTarget;miRNATAP -0.101022503267004 0.00879990555288765 NA NA NA hsa-miR-27b-3p RPS6KB1 -0.439806942644624 0.000523870009254693 0.133696512456113 0.119044963514929 MirTarget;miRNATAP -0.133934473956078 0.00122057856756205 NA NA NA hsa-miR-30b-5p RPS6KB1 -0.0106833209203501 0.954966272944722 0.133696512456113 0.119044963514929 mirMAP -0.113816711776284 3.41118475513608e-05 NA NA NA hsa-miR-337-3p RPS6KB1 -0.228166532308969 0.303588587461454 0.133696512456113 0.119044963514929 MirTarget;PITA -0.1265744624501 3.92719314737179e-08 NA NA NA hsa-miR-361-3p RPTOR 0.485361250955594 0.00074097948047418 0.123463591020488 0.186000294140961 MirTarget -0.146414674618989 0.000203466985434108 NA NA NA hsa-miR-423-3p RXRA 1.0646553568956 2.48410617381049e-08 -0.589168533256601 8.96247370284568e-07 miRNAWalker2_validate -0.130492655863266 0.000608438430028491 NA NA NA hsa-miR-361-5p SGK1 0.538048008019709 1.61165802415302e-07 -1.23516269266425 3.93616487822733e-10 miRanda -0.34181868200101 0.00550055041262113 NA NA NA hsa-miR-126-5p SGK3 0.450893496822779 0.0112966412858755 0.125936271658974 0.267550958629338 mirMAP -0.139032993506591 0.00033517940543204 NA NA NA hsa-miR-30a-5p SGK3 -0.742755040631906 3.79943871404435e-05 0.125936271658974 0.267550958629338 miRNATAP -0.112571294998231 0.00306550517437007 NA NA NA hsa-miR-326 SGK3 -0.552187708067123 0.039648668341622 0.125936271658974 0.267550958629338 miRanda -0.104619448365122 4.11769887462694e-05 NA NA NA hsa-miR-106b-5p SOS1 1.08518388423396 4.82746923373852e-09 0.0316954765218727 0.72051320984822 MirTarget;miRNATAP -0.119774013910386 1.84224503642486e-05 NA NA NA hsa-miR-125a-3p SOS1 0.0862037949225951 0.688453004025032 0.0316954765218727 0.72051320984822 miRanda -0.112424599645259 7.54563329172703e-06 NA NA NA hsa-miR-126-5p SOS1 0.450893496822779 0.0112966412858755 0.0316954765218727 0.72051320984822 mirMAP;miRNATAP -0.161911933244333 4.57843364648362e-08 NA NA NA hsa-miR-148b-3p SOS1 0.719517328390822 3.51245964668412e-05 0.0316954765218727 0.72051320984822 MirTarget -0.13940657543718 4.11419420385598e-06 NA NA NA hsa-miR-152-3p SOS1 -0.111001946024117 0.385698870309139 0.0316954765218727 0.72051320984822 MirTarget -0.135737045504372 0.00151193965635078 NA NA NA hsa-miR-186-5p SOS1 0.35512789129261 0.0196931838168008 0.0316954765218727 0.72051320984822 MirTarget;mirMAP -0.128916156131245 0.000268962886749121 NA NA NA hsa-miR-193a-3p SOS1 0.148284355948959 0.379093889907371 0.0316954765218727 0.72051320984822 miRanda -0.122331890760887 0.000128240120164947 NA NA NA hsa-miR-197-3p SOS1 0.540951726189935 0.00440139185360704 0.0316954765218727 0.72051320984822 miRNATAP -0.102130652419096 0.000277539675913793 NA NA NA hsa-miR-22-5p SOS1 0.668839167786886 0.00102248931590479 0.0316954765218727 0.72051320984822 miRNATAP -0.143915792576636 2.0159107401043e-08 NA NA NA hsa-miR-27a-3p SOS1 0.523219911315699 0.000116410279757859 0.0316954765218727 0.72051320984822 MirTarget;miRNATAP -0.213364589372616 4.16176840037259e-08 NA NA NA hsa-miR-27b-3p SOS1 -0.439806942644624 0.000523870009254693 0.0316954765218727 0.72051320984822 MirTarget;miRNATAP -0.139347121134051 0.00110109002177901 NA NA NA hsa-miR-299-5p SOS1 -0.162422032147768 0.435278723340297 0.0316954765218727 0.72051320984822 MirTarget -0.103730990538348 6.27872620143433e-05 NA NA NA hsa-miR-30b-5p SOS1 -0.0106833209203501 0.954966272944722 0.0316954765218727 0.72051320984822 mirMAP -0.133332751644771 2.23760849212247e-06 NA NA NA hsa-miR-320a SOS1 0.451741078692272 0.00893327237386749 0.0316954765218727 0.72051320984822 miRanda -0.12787037935102 3.48207469818514e-05 NA NA NA hsa-miR-320b SOS1 1.21733873788625 7.99882585998487e-07 0.0316954765218727 0.72051320984822 miRanda -0.11075201910725 1.17293038047398e-07 NA NA NA hsa-miR-326 SOS1 -0.552187708067123 0.039648668341622 0.0316954765218727 0.72051320984822 miRanda;miRNATAP -0.116317816021725 2.25701325943907e-09 NA NA NA hsa-miR-330-5p SOS1 0.621676971901542 0.00233177378595631 0.0316954765218727 0.72051320984822 miRanda;miRNATAP -0.129910192103186 4.58607726067456e-07 NA NA NA hsa-miR-33a-3p SOS1 0.21453033253985 0.371591474252951 0.0316954765218727 0.72051320984822 MirTarget -0.125048763565654 4.98370996029222e-08 NA NA NA hsa-miR-365a-3p SOS1 -0.801671336684825 1.28258342849568e-06 0.0316954765218727 0.72051320984822 miRNATAP -0.143518244732294 5.87421150982849e-06 NA NA NA hsa-miR-374a-3p SOS1 0.0703956336838676 0.602396227448772 0.0316954765218727 0.72051320984822 mirMAP -0.142015318716902 0.000428972507164654 NA NA NA hsa-miR-374b-5p SOS1 0.00249900187478502 0.985380083859555 0.0316954765218727 0.72051320984822 MirTarget;miRNATAP -0.162336854090079 4.50626900184473e-05 NA NA NA hsa-miR-495-3p SOS1 -0.024887553302567 0.897251687801771 0.0316954765218727 0.72051320984822 mirMAP -0.100903217402916 0.000297879441170268 NA NA NA hsa-miR-550a-5p SOS1 1.55643544666056 8.53097422057455e-09 0.0316954765218727 0.72051320984822 MirTarget -0.103550649374106 7.5387064217318e-08 NA NA NA hsa-miR-590-3p SOS1 0.858742926831233 0.000127281269371976 0.0316954765218727 0.72051320984822 miRanda;mirMAP;miRNATAP -0.133458462280817 8.69563696833037e-09 NA NA NA hsa-miR-590-5p SOS1 0.932604531809045 8.39043954167884e-05 0.0316954765218727 0.72051320984822 miRanda -0.104031381841187 2.53391203347257e-06 NA NA NA hsa-miR-628-5p SOS1 -0.0242002274581137 0.900266755757793 0.0316954765218727 0.72051320984822 miRNATAP -0.145976424234213 1.04451937140293e-07 NA NA NA hsa-let-7a-3p SOS2 0.283468597868531 0.127007787220086 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.214136379060167 7.71524686810599e-12 NA NA NA hsa-let-7b-3p SOS2 0.377956364821509 0.0061730103051373 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.294588459318382 3.29900209594529e-12 NA NA NA hsa-miR-130a-3p SOS2 0.218018009582956 0.274232880676821 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.128013636798398 1.87410389962494e-05 NA NA NA hsa-miR-130b-3p SOS2 1.29757792612022 1.70655148591568e-06 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.166507057651152 4.84194925163557e-16 NA NA NA hsa-miR-140-5p SOS2 0.132398579631585 0.457960134430787 -0.42663804059683 1.0961050076461e-05 miRanda -0.221961484464511 1.13546882104604e-11 NA NA NA hsa-miR-146b-5p SOS2 2.23105707690238 3.83997814011313e-23 -0.42663804059683 1.0961050076461e-05 miRanda -0.109254206460606 5.94271976028763e-06 NA NA NA hsa-miR-148a-3p SOS2 -0.18108394434325 0.495345303586758 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.111066000335572 5.79281796801942e-07 NA NA NA hsa-miR-154-5p SOS2 0.080205508185929 0.719781991745231 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.132241670773128 1.26139705090057e-06 NA NA NA hsa-miR-15a-5p SOS2 1.07800995489566 4.32072598796529e-10 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.122125950802965 0.000280319209074425 NA NA NA hsa-miR-15b-5p SOS2 0.637819606405168 0.000580041575431604 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.211562280968644 1.01083896548239e-11 NA NA NA hsa-miR-16-5p SOS2 0.468459442059375 0.02635007201346 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.210957704787092 6.34408939150223e-15 NA NA NA hsa-miR-193b-3p SOS2 -0.0325435210716751 0.883410452152887 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.138633984597814 1.92609137132289e-07 NA NA NA hsa-miR-21-5p SOS2 2.21515015440792 6.0468197386674e-49 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.110175887586637 0.000892255788702267 NA NA NA hsa-miR-301a-3p SOS2 1.22580753116505 5.84016077664577e-09 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.14798610603926 4.99310748691798e-08 NA NA NA hsa-miR-320a SOS2 0.451741078692272 0.00893327237386749 -0.42663804059683 1.0961050076461e-05 miRanda;miRNATAP -0.182167877222782 9.54183860705539e-08 NA NA NA hsa-miR-320b SOS2 1.21733873788625 7.99882585998487e-07 -0.42663804059683 1.0961050076461e-05 miRanda;miRNATAP -0.185627713247734 1.62491325700678e-16 NA NA NA hsa-miR-330-3p SOS2 0.391166748754241 0.0581284813543685 -0.42663804059683 1.0961050076461e-05 PITA;miRNATAP -0.142781151212482 1.48767453836625e-06 NA NA NA hsa-miR-335-5p SOS2 0.576542642348884 0.01886326850059 -0.42663804059683 1.0961050076461e-05 miRNAWalker2_validate -0.126061102705948 1.49015727063493e-07 NA NA NA hsa-miR-424-5p SOS2 0.956135912596328 0.00035164943928494 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.183100665972057 1.19405161552253e-18 NA NA NA hsa-miR-454-3p SOS2 0.823770738595667 1.30339728183332e-05 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.1772895052455 7.20861491062917e-09 NA NA NA hsa-miR-493-5p SOS2 1.32223598235404 3.01688809960418e-10 -0.42663804059683 1.0961050076461e-05 miRNATAP -0.174098463305458 7.81376051613837e-11 NA NA NA hsa-miR-590-3p SOS2 0.858742926831233 0.000127281269371976 -0.42663804059683 1.0961050076461e-05 miRanda;mirMAP -0.193069116920734 2.41257806622236e-14 NA NA NA hsa-miR-590-5p SOS2 0.932604531809045 8.39043954167884e-05 -0.42663804059683 1.0961050076461e-05 PITA;miRanda;miRNATAP -0.170506191845349 1.37848320935466e-12 NA NA NA hsa-miR-139-5p SPP1 -1.41674256628297 4.51005988644234e-14 3.10583596858925 3.52647854874352e-14 miRanda -0.790023796523151 1.54895494876168e-09 NA NA NA hsa-miR-30a-3p SYK -1.27950866170419 4.33230022379782e-09 0.172496759960336 0.293033311846796 mirMAP -0.141985848639185 0.00144140177944049 NA NA NA hsa-miR-421 TEK 1.26653675546617 2.35180826009926e-08 -0.345136441970626 0.065903561477765 miRanda -0.300329915813501 5.6730807273941e-10 NA NA NA hsa-miR-455-5p TEK 0.644390760445571 0.00262275997170695 -0.345136441970626 0.065903561477765 miRanda -0.213159225871554 5.74785345900136e-05 NA NA NA hsa-miR-140-3p TGFA -0.0247056136502994 0.830704277191343 0.164946978335892 0.516527092850513 miRNATAP -0.72657510284151 8.69184138335946e-08 NA NA NA hsa-miR-28-5p TGFA -0.22318016376076 0.0194144033008573 0.164946978335892 0.516527092850513 miRanda -0.50847358966191 0.00267274322388582 NA NA NA hsa-let-7a-3p THBS1 0.283468597868531 0.127007787220086 0.740672313122665 0.00386405601476247 mirMAP -0.489041330432626 4.33695244105882e-09 NA NA NA hsa-let-7b-3p THBS1 0.377956364821509 0.0061730103051373 0.740672313122665 0.00386405601476247 MirTarget;mirMAP -0.365339191992028 0.00154703333333996 NA NA NA hsa-let-7d-5p THBS1 0.686819803681087 1.08347860862215e-06 0.740672313122665 0.00386405601476247 miRNAWalker2_validate -0.506056181556372 4.25285737819245e-06 NA NA NA hsa-let-7f-1-3p THBS1 1.09636075438131 3.42037366931931e-10 0.740672313122665 0.00386405601476247 mirMAP -0.363492571441378 2.99651611560672e-05 NA NA NA hsa-miR-151a-3p THBS1 0.968493853072108 1.28305876770564e-12 0.740672313122665 0.00386405601476247 MirTarget -0.382128237342153 0.000637998715574637 NA NA NA hsa-miR-155-5p THBS1 0.708423342476697 0.00686702252429413 0.740672313122665 0.00386405601476247 miRNAWalker2_validate;mirMAP -0.222886450295068 0.000180193487212198 NA NA NA hsa-miR-16-1-3p THBS1 1.23864765632542 1.24544799589822e-08 0.740672313122665 0.00386405601476247 MirTarget -0.412791178512272 6.59648473112284e-09 NA NA NA hsa-miR-17-5p THBS1 1.57209612312313 5.10453838016207e-11 0.740672313122665 0.00386405601476247 miRNAWalker2_validate -0.324812392354921 1.87626559287448e-07 NA NA NA hsa-miR-182-5p THBS1 1.73826081735237 5.69817940588551e-09 0.740672313122665 0.00386405601476247 MirTarget -0.334543300157695 1.29813558395368e-11 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.35512789129261 0.0196931838168008 0.740672313122665 0.00386405601476247 mirMAP -0.529010018509587 2.62083931794345e-07 NA NA NA hsa-miR-18a-5p THBS1 2.04701000113742 1.30593450319289e-12 0.740672313122665 0.00386405601476247 MirTarget -0.249337071803029 1.24104410872786e-06 NA NA NA hsa-miR-19a-3p THBS1 1.71062381299889 1.72281025366819e-11 0.740672313122665 0.00386405601476247 MirTarget;mirMAP -0.321271229223972 3.65296300526283e-08 NA NA NA hsa-miR-19b-3p THBS1 0.936987029203338 9.28141970787798e-06 0.740672313122665 0.00386405601476247 MirTarget;mirMAP -0.501290446541713 1.40659785646321e-12 NA NA NA hsa-miR-200a-5p THBS1 2.19152245759943 3.17968183522514e-11 0.740672313122665 0.00386405601476247 MirTarget -0.283869686404899 1.6588159525732e-10 NA NA NA hsa-miR-200b-5p THBS1 0.934206940937576 0.00554096871767416 0.740672313122665 0.00386405601476247 MirTarget -0.342376588917334 2.20100128577477e-13 NA NA NA hsa-miR-20a-5p THBS1 1.57190995476158 8.72275528729458e-12 0.740672313122665 0.00386405601476247 miRNAWalker2_validate -0.289254457616536 8.78230806981051e-06 NA NA NA hsa-miR-29b-1-5p THBS1 1.27585983480192 1.70509960024426e-05 0.740672313122665 0.00386405601476247 mirMAP -0.212569984297237 4.57485313893413e-05 NA NA NA hsa-miR-32-5p THBS1 0.425717775201634 0.0402079308210921 0.740672313122665 0.00386405601476247 mirMAP -0.533162871730824 2.69674865435064e-13 NA NA NA hsa-miR-335-3p THBS1 2.29463721765513 4.1956113745077e-18 0.740672313122665 0.00386405601476247 mirMAP -0.116746872361894 0.0367223970639482 NA NA NA hsa-miR-338-3p THBS1 -0.0138760121093551 0.956163634155272 0.740672313122665 0.00386405601476247 MirTarget;PITA;miRanda -0.201156659073858 0.00127823881072701 NA NA NA hsa-miR-33a-3p THBS1 0.21453033253985 0.371591474252951 0.740672313122665 0.00386405601476247 MirTarget;mirMAP -0.412199944259148 7.30759277826103e-10 NA NA NA hsa-miR-375 THBS1 -0.348733074320394 0.47719066431766 0.740672313122665 0.00386405601476247 miRanda -0.131897433472452 3.25377278383715e-05 NA NA NA hsa-miR-421 THBS1 1.26653675546617 2.35180826009926e-08 0.740672313122665 0.00386405601476247 miRanda -0.192962909393047 0.00484005800882235 NA NA NA hsa-miR-455-5p THBS1 0.644390760445571 0.00262275997170695 0.740672313122665 0.00386405601476247 miRanda -0.429624105767455 1.81463611151616e-09 NA NA NA hsa-miR-500a-5p THBS1 1.33126717816499 3.1497328652235e-07 0.740672313122665 0.00386405601476247 mirMAP -0.305234274757475 1.5137854824058e-07 NA NA NA hsa-miR-576-5p THBS1 0.872721964495849 5.20470410008775e-05 0.740672313122665 0.00386405601476247 mirMAP -0.36831464781122 2.17869034477973e-07 NA NA NA hsa-miR-577 THBS1 0.615893340074725 0.210494450869356 0.740672313122665 0.00386405601476247 mirMAP -0.19627945048917 8.23792509270804e-09 NA NA NA hsa-miR-589-3p THBS1 1.00357906465313 8.20399071001461e-05 0.740672313122665 0.00386405601476247 mirMAP -0.2564330417496 6.21533453653462e-05 NA NA NA hsa-miR-590-3p THBS1 0.858742926831233 0.000127281269371976 0.740672313122665 0.00386405601476247 miRanda -0.474515007790973 1.56766885279028e-12 NA NA NA hsa-miR-590-5p THBS1 0.932604531809045 8.39043954167884e-05 0.740672313122665 0.00386405601476247 miRanda;mirMAP -0.38177161783531 2.74632610530403e-09 NA NA NA hsa-miR-629-3p THBS1 0.597278340934362 0.0508108703940013 0.740672313122665 0.00386405601476247 MirTarget -0.26181406016391 1.40628693992547e-06 NA NA NA hsa-miR-664a-3p THBS1 -0.0290482945770787 0.844010225386475 0.740672313122665 0.00386405601476247 mirMAP -0.391160913306104 0.000293389052354606 NA NA NA hsa-miR-671-5p THBS1 1.6497630797889 2.89172004241043e-12 0.740672313122665 0.00386405601476247 MirTarget -0.300124650479729 1.97423226010358e-06 NA NA NA hsa-miR-7-1-3p THBS1 0.94398354303717 7.5771319809992e-05 0.740672313122665 0.00386405601476247 MirTarget;mirMAP -0.398134296874996 3.46803127332158e-10 NA NA NA hsa-miR-92a-3p THBS1 1.06124545165614 6.51550014372282e-08 0.740672313122665 0.00386405601476247 miRNAWalker2_validate -0.411637540352431 9.51200767861894e-08 NA NA NA hsa-miR-940 THBS1 1.3080677738253 2.0056085433599e-05 0.740672313122665 0.00386405601476247 MirTarget -0.110947001964159 0.0333473723090718 NA NA NA hsa-miR-98-5p THBS1 0.72508924193932 6.07191196761022e-10 0.740672313122665 0.00386405601476247 miRNAWalker2_validate -0.508893784656041 0.000123995286478327 NA NA NA hsa-miR-106a-5p THBS2 0.587427028487119 0.00838999163993323 2.8054297125201 9.42824308886052e-18 MirTarget -0.192236871978497 0.0452360561888623 NA NA NA hsa-miR-106b-5p THBS2 1.08518388423396 4.82746923373852e-09 2.8054297125201 9.42824308886052e-18 MirTarget -0.221811092448055 0.0495240053387811 NA NA NA hsa-miR-139-5p THBS2 -1.41674256628297 4.51005988644234e-14 2.8054297125201 9.42824308886052e-18 miRanda -0.360475838909774 0.000885181012926372 NA NA NA hsa-miR-16-2-3p THBS2 0.869267463341732 0.000785361809327569 2.8054297125201 9.42824308886052e-18 mirMAP -0.23240400755256 0.00449422401493209 NA NA NA hsa-miR-182-5p THBS2 1.73826081735237 5.69817940588551e-09 2.8054297125201 9.42824308886052e-18 MirTarget;miRNATAP -0.179469061165105 0.009779380956542 NA NA NA hsa-miR-20b-5p THBS2 -0.251408129904656 0.380168040769502 2.8054297125201 9.42824308886052e-18 MirTarget -0.152285088205977 0.0418531051168588 NA NA NA hsa-miR-29a-3p THBS2 -0.235052170104117 0.138527567930958 2.8054297125201 9.42824308886052e-18 MirTarget -0.633066965171942 2.44624156556725e-06 NA NA NA hsa-miR-29b-3p THBS2 0.0225365195743876 0.914313337784307 2.8054297125201 9.42824308886052e-18 MirTarget -0.502326334114595 6.48410121217896e-07 NA NA NA hsa-miR-29c-3p THBS2 -1.34143813218298 2.77493790306384e-12 2.8054297125201 9.42824308886052e-18 MirTarget -0.730863721658318 1.25228077886296e-12 NA NA NA hsa-miR-3614-5p THBS2 0.288051497709626 0.339707047011435 2.8054297125201 9.42824308886052e-18 miRNATAP -0.263911421616625 0.000759586687484251 NA NA NA hsa-miR-590-3p THBS2 0.858742926831233 0.000127281269371976 2.8054297125201 9.42824308886052e-18 miRanda;mirMAP -0.298144436976227 0.00159094394829244 NA NA NA hsa-miR-590-5p THBS2 0.932604531809045 8.39043954167884e-05 2.8054297125201 9.42824308886052e-18 miRanda -0.211114064657501 0.0182868067359077 NA NA NA hsa-miR-598-3p THBS2 -0.111666719816677 0.600406811579071 2.8054297125201 9.42824308886052e-18 MirTarget -0.373759626425914 0.000189486625765926 NA NA NA hsa-miR-7-1-3p THBS2 0.94398354303717 7.5771319809992e-05 2.8054297125201 9.42824308886052e-18 MirTarget;mirMAP -0.214874404471636 0.0154118998563762 NA NA NA hsa-miR-96-5p THBS2 1.44821155854693 6.56312590328933e-06 2.8054297125201 9.42824308886052e-18 TargetScan;miRNATAP -0.197634353089818 0.00449738570431194 NA NA NA hsa-miR-326 THBS3 -0.552187708067123 0.039648668341622 0.269086856046887 0.0642737493288086 PITA -0.162489296097943 6.0000136596835e-07 NA NA NA hsa-miR-330-5p THBS3 0.621676971901542 0.00233177378595631 0.269086856046887 0.0642737493288086 PITA;miRNATAP -0.314086320143297 3.36811511460786e-14 NA NA NA hsa-miR-423-5p THBS3 0.554579912507932 7.65114789083517e-05 0.269086856046887 0.0642737493288086 PITA;miRNATAP -0.225862426852719 0.000357889880082556 NA NA NA hsa-miR-550a-5p THBS3 1.55643544666056 8.53097422057455e-09 0.269086856046887 0.0642737493288086 MirTarget -0.176140881529549 3.17331765203083e-08 NA NA NA hsa-miR-142-3p THBS4 1.80134804047727 3.87649742898476e-07 1.26425821889351 0.0346262811621478 miRanda -0.351597475805796 0.000462187293962447 NA NA NA hsa-miR-320a THBS4 0.451741078692272 0.00893327237386749 1.26425821889351 0.0346262811621478 miRanda -0.694328339607131 0.00109747916685224 NA NA NA hsa-miR-320b THBS4 1.21733873788625 7.99882585998487e-07 1.26425821889351 0.0346262811621478 miRanda -0.671514847587339 3.07274310123264e-06 NA NA NA hsa-miR-140-5p THEM4 0.132398579631585 0.457960134430787 0.456118214991815 0.000630288666163555 miRanda -0.113237402954022 0.014927690786474 NA NA NA hsa-miR-17-5p TLR4 1.57209612312313 5.10453838016207e-11 0.251020910674129 0.180645830541839 TargetScan -0.131661602068622 0.00427240198805587 NA NA NA hsa-miR-335-5p TLR4 0.576542642348884 0.01886326850059 0.251020910674129 0.180645830541839 miRNAWalker2_validate -0.122032385770027 0.00906779884260206 NA NA NA hsa-miR-338-5p TLR4 -0.420442436641152 0.0583175290447746 0.251020910674129 0.180645830541839 MirTarget -0.127488288965039 0.0138704566697674 NA NA NA hsa-miR-590-5p TLR4 0.932604531809045 8.39043954167884e-05 0.251020910674129 0.180645830541839 miRanda -0.123161206302397 0.0101355271705785 NA NA NA hsa-miR-7-1-3p TLR4 0.94398354303717 7.5771319809992e-05 0.251020910674129 0.180645830541839 mirMAP -0.11501139612358 0.0155479889708913 NA NA NA hsa-miR-7-5p TLR4 1.20202447072014 0.000123775346787165 0.251020910674129 0.180645830541839 MirTarget -0.126372262839333 0.00101287180453681 24004462 Our recent evidence showed that Toll like receptor 9 TLR9 signaling could enhance the growth and metastatic potential of human lung cancer cells through repressing microRNA-7 miR-7 expression lung cancer hsa-miR-126-5p TNC 0.450893496822779 0.0112966412858755 0.313378182716056 0.337051499348125 miRNATAP -0.43415899507512 0.000101327063415425 NA NA NA hsa-miR-326 TNC -0.552187708067123 0.039648668341622 0.313378182716056 0.337051499348125 MirTarget;miRanda;miRNATAP -0.31773356682785 1.55117202044515e-05 NA NA NA hsa-miR-330-3p TNC 0.391166748754241 0.0581284813543685 0.313378182716056 0.337051499348125 MirTarget -0.525074835598826 9.1183206616119e-08 NA NA NA hsa-miR-330-5p TNC 0.621676971901542 0.00233177378595631 0.313378182716056 0.337051499348125 MirTarget;miRanda;miRNATAP -0.5996897802624 2.20029061904363e-10 NA NA NA hsa-miR-335-5p TNC 0.576542642348884 0.01886326850059 0.313378182716056 0.337051499348125 miRNAWalker2_validate;miRTarBase -0.441296058735744 3.01544164882285e-08 NA NA NA hsa-miR-425-5p TNC 0.865319550452351 0.000902803064763851 0.313378182716056 0.337051499348125 MirTarget -0.497181796795447 1.09269065599689e-11 NA NA NA hsa-miR-486-5p TNC -1.52128065772506 4.50915908626354e-09 0.313378182716056 0.337051499348125 PITA;miRanda -0.19659178160074 0.00846308584038084 NA NA NA hsa-miR-501-5p TNC 1.59306197632625 2.04856600619363e-09 0.313378182716056 0.337051499348125 miRNATAP -0.503639676017705 7.29996947918808e-12 NA NA NA hsa-miR-505-5p TNC 0.587017903980186 0.0146321695489627 0.313378182716056 0.337051499348125 MirTarget -0.400712655870849 1.37737320919019e-06 NA NA NA hsa-miR-590-3p TNC 0.858742926831233 0.000127281269371976 0.313378182716056 0.337051499348125 miRanda -0.686825036275669 2.03643392620694e-16 NA NA NA hsa-miR-140-5p TNN 0.132398579631585 0.457960134430787 0.139948688866828 0.714186622838136 PITA;miRanda -0.387846430361842 0.00327636007677826 NA NA NA hsa-miR-338-3p TNN -0.0138760121093551 0.956163634155272 0.139948688866828 0.714186622838136 miRanda -0.306302210415359 0.000913201573228506 NA NA NA hsa-miR-141-3p TNR 1.76274853293464 9.99331900755725e-07 -1.00929416956303 0.0160324833074989 TargetScan -0.344340082301751 5.20163806042666e-07 NA NA NA hsa-miR-320b TNR 1.21733873788625 7.99882585998487e-07 -1.00929416956303 0.0160324833074989 miRanda -0.227671622874537 0.0263709419236377 NA NA NA hsa-miR-330-5p TNR 0.621676971901542 0.00233177378595631 -1.00929416956303 0.0160324833074989 MirTarget;miRanda -0.309106592128933 0.0140742375133854 NA NA NA hsa-miR-484 TNR 0.401753773460753 0.0490851523101605 -1.00929416956303 0.0160324833074989 MirTarget -0.424032263307588 0.00075936334451859 NA NA NA hsa-miR-7-1-3p TNR 0.94398354303717 7.5771319809992e-05 -1.00929416956303 0.0160324833074989 MirTarget -0.414288954477167 9.12736554404696e-05 NA NA NA hsa-miR-1301-3p TNXB 1.62626930622185 2.81303026159352e-11 -1.2654206510032 2.78720071551318e-08 miRNAWalker2_validate -0.336382777376077 8.24975000721118e-10 NA NA NA hsa-miR-30b-5p TNXB -0.0106833209203501 0.954966272944722 -1.2654206510032 2.78720071551318e-08 mirMAP -0.266686671681547 0.000442007794732353 NA NA NA hsa-miR-3607-3p TNXB 0.479939234340415 0.251616873367277 -1.2654206510032 2.78720071551318e-08 miRNATAP -0.100553844462346 0.00420176843539107 NA NA NA hsa-miR-125a-5p TP53 -0.261743402170195 0.116107665196876 0.511940387522054 0.00485905823274999 miRNAWalker2_validate;miRTarBase;miRanda -0.244153419981785 0.000286434605400778 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.176364454911029 0.43771853581292 0.511940387522054 0.00485905823274999 miRNAWalker2_validate;miRTarBase -0.117991649104916 0.0168993998720041 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-140-5p TSC1 0.132398579631585 0.457960134430787 0.103376413669437 0.260710731616936 miRanda -0.133192196277832 1.99099160894571e-05 NA NA NA hsa-miR-154-5p TSC1 0.080205508185929 0.719781991745231 0.103376413669437 0.260710731616936 mirMAP -0.12030759854282 2.20438172100311e-06 NA NA NA hsa-miR-155-5p TSC1 0.708423342476697 0.00686702252429413 0.103376413669437 0.260710731616936 mirMAP -0.102631949573312 8.39615862659847e-07 NA NA NA hsa-miR-186-5p TSC1 0.35512789129261 0.0196931838168008 0.103376413669437 0.260710731616936 mirMAP -0.118010796767678 0.00137478569971358 NA NA NA hsa-miR-2355-3p TSC1 0.101789577163865 0.693158423682028 0.103376413669437 0.260710731616936 mirMAP -0.110058374075419 7.42692937358939e-07 NA NA NA hsa-miR-495-3p TSC1 -0.024887553302567 0.897251687801771 0.103376413669437 0.260710731616936 mirMAP -0.100664966997043 0.000523148100933423 NA NA NA hsa-miR-17-5p TSC2 1.57209612312313 5.10453838016207e-11 -0.187160538327766 0.0176263677318318 miRNAWalker2_validate -0.101768032578338 7.16961430311078e-08 NA NA NA hsa-miR-744-5p TSC2 0.734924181943417 2.06706878377701e-05 -0.187160538327766 0.0176263677318318 miRNAWalker2_validate -0.105969896661177 0.000107604990766944 NA NA NA hsa-miR-1-3p VEGFA -2.73171785118192 3.4424534921136e-12 0.628775505110226 0.000620913144913639 MirTarget -0.160096444278202 2.39807937646162e-09 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA -0.0683272309939689 0.544163124741916 0.628775505110226 0.000620913144913639 miRNAWalker2_validate -0.234969291392252 0.0239176691767107 NA NA NA hsa-miR-129-5p VEGFA -1.61803714443871 4.93214379865694e-06 0.628775505110226 0.000620913144913639 miRanda -0.123149206855853 0.000102224632725905 NA NA NA hsa-miR-133a-3p VEGFA -2.63342156915404 5.72661351480585e-12 0.628775505110226 0.000620913144913639 miRNAWalker2_validate -0.17467432535846 2.12949891237168e-10 NA NA NA hsa-miR-145-5p VEGFA -1.54503595327403 2.65080161523141e-09 0.628775505110226 0.000620913144913639 miRNAWalker2_validate;miRTarBase -0.19967828420984 1.67016514549082e-06 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-195-5p VEGFA -1.07154705036962 4.16544134775761e-08 0.628775505110226 0.000620913144913639 miRNAWalker2_validate;miRTarBase;MirTarget -0.293488826214044 1.3561926096363e-07 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.723739336873244 5.69674696426761e-05 0.628775505110226 0.000620913144913639 miRanda;miRNATAP -0.150698964475885 0.0162735670192175 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.621733599295605 0.000811860893066088 0.628775505110226 0.000620913144913639 miRanda -0.196918762893772 0.00117883924199798 NA NA NA hsa-miR-29c-3p VEGFA -1.34143813218298 2.77493790306384e-12 0.628775505110226 0.000620913144913639 miRNAWalker2_validate;MirTarget -0.218866101324082 0.000104112123510008 NA NA NA hsa-miR-497-5p VEGFA -0.486115215577409 0.00973897247186318 0.628775505110226 0.000620913144913639 MirTarget -0.269299599061328 6.25398716766789e-06 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-128-3p VEGFC 0.835320684237761 1.85756253116961e-09 0.303026541762733 0.061231590390871 miRNAWalker2_validate;MirTarget -0.361887268982342 1.43313311366337e-07 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 0.869267463341732 0.000785361809327569 0.303026541762733 0.061231590390871 MirTarget -0.255509137467911 2.41587247429932e-12 NA NA NA hsa-miR-27a-3p VEGFC 0.523219911315699 0.000116410279757859 0.303026541762733 0.061231590390871 MirTarget -0.241070024376044 0.000973912124066657 NA NA NA hsa-miR-338-5p VEGFC -0.420442436641152 0.0583175290447746 0.303026541762733 0.061231590390871 MirTarget;PITA;miRNATAP -0.184065593719058 3.25843721417238e-05 NA NA NA hsa-miR-590-3p VEGFC 0.858742926831233 0.000127281269371976 0.303026541762733 0.061231590390871 miRanda -0.275054507394025 9.11368151957866e-11 NA NA NA hsa-miR-15a-5p VWF 1.07800995489566 4.32072598796529e-10 0.19886176095982 0.31079150620286 mirMAP -0.253012975252508 0.00016385186924196 NA NA NA hsa-miR-15b-5p VWF 0.637819606405168 0.000580041575431604 0.19886176095982 0.31079150620286 mirMAP -0.205887184995922 0.00135815828396163 NA NA NA hsa-miR-16-5p VWF 0.468459442059375 0.02635007201346 0.19886176095982 0.31079150620286 mirMAP -0.151394699339793 0.00774928172095829 NA NA NA hsa-miR-429 VWF 1.58250682050303 4.75828087352234e-05 0.19886176095982 0.31079150620286 miRNATAP -0.136752471868605 6.65411633313851e-06 NA NA NA hsa-miR-152-3p YWHAB -0.111001946024117 0.385698870309139 0.358450947948359 0.000102547253240136 MirTarget -0.179350543423211 6.71755050267786e-05 NA NA NA hsa-miR-28-3p YWHAB -0.247525872199168 0.0399632425440147 0.358450947948359 0.000102547253240136 mirMAP -0.182926147443985 0.000132030842494469 NA NA NA hsa-let-7e-5p YWHAE 0.227253058773149 0.162290058199053 0.0014146052214663 0.989053236383299 miRNAWalker2_validate -0.145244264457431 0.000171335631614497 NA NA NA hsa-miR-100-5p YWHAE -0.343735526262058 0.133995182819209 0.0014146052214663 0.989053236383299 miRNAWalker2_validate -0.165321463960734 4.66054831564133e-10 NA NA NA hsa-miR-199a-5p YWHAE 0.723739336873244 5.69674696426761e-05 0.0014146052214663 0.989053236383299 miRanda -0.126354603451383 0.00023919407949176 NA NA NA hsa-miR-30a-3p YWHAE -1.27950866170419 4.33230022379782e-09 0.0014146052214663 0.989053236383299 miRNAWalker2_validate;MirTarget;miRNATAP -0.110793730596684 6.37860699089308e-05 NA NA NA hsa-miR-30a-5p YWHAE -0.742755040631906 3.79943871404435e-05 0.0014146052214663 0.989053236383299 miRNAWalker2_validate -0.185372712608919 3.9245917940403e-08 NA NA NA hsa-miR-139-5p YWHAG -1.41674256628297 4.51005988644234e-14 0.478543013351851 2.65743654788031e-07 MirTarget;PITA;miRanda;miRNATAP -0.158866302782212 3.42487732094063e-08 NA NA NA hsa-miR-140-3p YWHAG -0.0247056136502994 0.830704277191343 0.478543013351851 2.65743654788031e-07 MirTarget;PITA;miRNATAP -0.222790199893634 1.24269618544803e-05 NA NA NA hsa-miR-30a-5p YWHAG -0.742755040631906 3.79943871404435e-05 0.478543013351851 2.65743654788031e-07 miRNATAP -0.129299012166129 4.16783465450433e-05 NA NA NA hsa-miR-30e-5p YWHAG -0.284839730810255 0.0405852891523165 0.478543013351851 2.65743654788031e-07 miRNATAP -0.109692567604298 0.00934652685443653 NA NA NA hsa-miR-361-3p YWHAG 0.485361250955594 0.00074097948047418 0.478543013351851 2.65743654788031e-07 miRNATAP -0.118409146649712 0.0033726001793077 NA NA NA hsa-miR-195-5p YWHAQ -1.07154705036962 4.16544134775761e-08 -0.00973354065713039 0.900690881591244 MirTarget;miRNATAP -0.111205053185529 1.74086595049359e-06 NA NA NA hsa-miR-497-5p YWHAQ -0.486115215577409 0.00973897247186318 -0.00973354065713039 0.900690881591244 MirTarget;miRNATAP -0.144445884894949 3.47651310790627e-09 NA NA NA hsa-miR-125a-5p YWHAZ -0.261743402170195 0.116107665196876 0.282448372408636 0.00823530141414023 miRanda -0.120899994936991 0.00222341225944007 NA NA NA hsa-miR-195-3p YWHAZ -0.694544351365025 0.000214711021317786 0.282448372408636 0.00823530141414023 MirTarget -0.22109891500738 4.56089153567995e-11 NA NA NA hsa-miR-199a-5p YWHAZ 0.723739336873244 5.69674696426761e-05 0.282448372408636 0.00823530141414023 miRanda -0.125296507021549 0.000493781046348479 NA NA NA hsa-miR-28-5p YWHAZ -0.22318016376076 0.0194144033008573 0.282448372408636 0.00823530141414023 PITA;miRanda;miRNATAP -0.256096950848326 0.000309149258141861 NA NA NA hsa-miR-30a-5p YWHAZ -0.742755040631906 3.79943871404435e-05 0.282448372408636 0.00823530141414023 miRNAWalker2_validate;MirTarget;miRNATAP -0.220719706054169 2.57782171927733e-10 NA NA NA