miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p AKT3 -1.46099200329485 7.85040381494472e-22 0.757395805826156 5.24354425444781e-05 PITA;miRanda -0.204988506808972 7.26517518198736e-05 NA NA NA hsa-miR-15a-5p AKT3 0.783550182002274 2.60699595655907e-11 0.757395805826156 5.24354425444781e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265716982670402 0.000109391971495535 NA NA NA hsa-miR-17-5p AKT3 1.41924888736771 2.75805544953758e-18 0.757395805826156 5.24354425444781e-05 TargetScan;miRNATAP -0.210478431167346 1.46778910374435e-05 NA NA NA hsa-miR-205-3p AKT3 1.2960640797621 5.80786479909147e-11 0.757395805826156 5.24354425444781e-05 mirMAP -0.248708307357298 5.71786142986847e-10 NA NA NA hsa-miR-20a-5p AKT3 1.1531986665452 1.02385132917958e-11 0.757395805826156 5.24354425444781e-05 miRNATAP -0.244010493055021 2.19437052623105e-07 NA NA NA hsa-miR-29b-3p AKT3 -0.110721443686039 0.511264554091106 0.757395805826156 5.24354425444781e-05 miRNATAP -0.255169036216248 1.32894370465011e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-362-3p AKT3 -0.697212068252854 2.61718493418184e-06 0.757395805826156 5.24354425444781e-05 miRanda -0.198442787422331 0.000314248564221821 NA NA NA hsa-miR-362-5p AKT3 0.41089772861323 0.0404254902071382 0.757395805826156 5.24354425444781e-05 PITA;TargetScan;miRNATAP -0.156881795440952 0.000120211641903581 NA NA NA hsa-miR-127-3p BAD -1.47175957435172 9.8707469067377e-14 0.232698220027489 0.0410974615650229 miRanda;miRNATAP -0.109748766939369 6.41360405115286e-06 NA NA NA hsa-miR-326 BAD -0.425943992128769 0.0415010315530797 0.232698220027489 0.0410974615650229 miRanda -0.161061952496571 5.50625637973764e-12 NA NA NA hsa-miR-193b-3p CASP9 1.72788400801602 3.0722151264559e-21 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.154521744765018 3.59150879724078e-12 NA NA NA hsa-miR-424-5p CASP9 1.48125289532143 9.10372985713165e-19 -0.463384781945098 2.35696508685012e-06 mirMAP -0.139144406558183 1.49418335447692e-08 NA NA NA hsa-miR-7-5p CASP9 1.55674721532755 2.41989824363914e-11 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.103910716853992 3.37252845720189e-08 NA NA NA hsa-miR-106b-5p CDC42 0.50378717276868 1.45412404526866e-05 0.0129593551240648 0.846406884079324 miRNAWalker2_validate -0.131295640190421 9.81003904528409e-08 NA NA NA hsa-miR-107 CDC42 -0.0447040564279497 0.671618791096755 0.0129593551240648 0.846406884079324 miRanda -0.130309156837011 2.19468768424638e-06 23627613 Quantitative real-time PCR was used to analyze the expression of miR-107 and its bioinformatically identified targets PIM-1 and CDC42 esophageal cancer hsa-miR-28-3p CDC42 0.459875450032895 3.47095927872566e-07 0.0129593551240648 0.846406884079324 PITA -0.127737879674437 6.54245576973787e-05 NA NA NA hsa-let-7a-5p HRAS -0.439381775414001 3.1119785480023e-05 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.301645525492195 8.02100955354543e-08 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.2489842756826 0.0211384499461719 0.26280245681614 0.0556242904507885 miRTarBase -0.216577181164546 9.6758212516064e-05 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.33760181792708 4.15335119989612e-12 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.249594509349032 2.27678793354297e-17 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-181d-5p HRAS 0.367649966373544 0.00537300571455306 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.122856153096347 0.00677992276763114 NA NA NA hsa-miR-330-5p JMJD7-PLA2G4B 0.944693925383906 5.04972895657346e-13 -0.796367559924462 7.52402910355677e-07 miRNATAP -0.189036602989866 0.000362977794134276 NA NA NA hsa-miR-542-3p JMJD7-PLA2G4B 0.643308814904977 8.81635403230104e-07 -0.796367559924462 7.52402910355677e-07 miRNATAP -0.316324839983911 2.59499534311272e-09 NA NA NA hsa-miR-149-5p KDR 0.443278770827687 0.0642022866136881 -0.0640531132877142 0.723023281947347 miRNATAP -0.163475530932982 4.97964788050635e-07 NA NA NA hsa-miR-15a-5p KDR 0.783550182002274 2.60699595655907e-11 -0.0640531132877142 0.723023281947347 miRNATAP -0.538223224088053 4.40254709356056e-17 NA NA NA hsa-miR-15b-5p KDR 0.85315666454713 3.79816274836297e-12 -0.0640531132877142 0.723023281947347 miRNATAP -0.23138999639968 0.00022888704644937 NA NA NA hsa-miR-16-5p KDR 0.521122945828175 1.40561786410572e-06 -0.0640531132877142 0.723023281947347 miRTarBase;miRNATAP -0.251278763057448 0.000528972295280267 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 0.757034032029085 2.99828133413343e-07 -0.0640531132877142 0.723023281947347 miRNAWalker2_validate -0.39505187814695 1.72509350482592e-14 NA NA NA hsa-miR-200b-3p KDR 0.0717138787925347 0.682858087587209 -0.0640531132877142 0.723023281947347 miRNAWalker2_validate;miRTarBase;TargetScan -0.263698570555775 2.67079529834483e-09 NA NA NA hsa-miR-200c-3p KDR 0.630251054099546 0.000131975031451555 -0.0640531132877142 0.723023281947347 miRNATAP -0.263590197962967 1.99844049333072e-08 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-338-3p KDR -0.948755228846395 8.99167125682392e-08 -0.0640531132877142 0.723023281947347 PITA;miRanda -0.198788405113943 4.97145669026782e-06 NA NA NA hsa-miR-429 KDR 0.559451508722375 0.00563641638673083 -0.0640531132877142 0.723023281947347 PITA;miRanda;miRNATAP -0.27245086358 7.76028904884939e-13 NA NA NA hsa-miR-455-5p KDR 1.408595672323 5.52039116456697e-22 -0.0640531132877142 0.723023281947347 PITA;miRanda;miRNATAP -0.275124811982307 7.69432624809677e-08 NA NA NA hsa-miR-590-3p KDR 0.221436901462551 0.0965904764063157 -0.0640531132877142 0.723023281947347 miRanda -0.170021217673703 0.00410155035555196 NA NA NA hsa-miR-590-5p KDR 0.763025362395968 3.65305892505623e-09 -0.0640531132877142 0.723023281947347 miRanda -0.418670351317141 1.21463513458081e-12 NA NA NA hsa-miR-664a-3p KDR -0.256108763664991 0.0513188660751664 -0.0640531132877142 0.723023281947347 mirMAP -0.192278642957014 0.00135050007055888 NA NA NA hsa-let-7a-3p KRAS 0.0966652362351867 0.423761916840503 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.136931356508913 0.000135436448739821 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-126-3p KRAS 0.0487843863772834 0.730130847436008 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRTarBase -0.115990819317181 0.0001500081257996 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-155-5p KRAS 0.533437622040649 0.00248671179205372 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRNATAP -0.106787251340147 1.12687232356945e-05 NA NA NA hsa-miR-181a-5p KRAS 0.819060835827404 1.38616688310277e-13 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate -0.206488916827338 5.30264645500736e-08 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-186-5p KRAS 0.353452958261612 0.000145058448579496 -0.0421192166497262 0.67210141138451 mirMAP -0.20957782293178 6.43868544074746e-06 NA NA NA hsa-miR-30a-5p KRAS -1.79779915425811 1.93360169837799e-26 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.109380981252874 6.01372957790632e-06 NA NA NA hsa-miR-30b-5p KRAS -0.400238605368173 0.00346540992719245 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.14630304008033 3.12182870258392e-06 NA NA NA hsa-miR-30c-5p KRAS 0.021222006155897 0.886366656528128 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.160986192000454 2.5135861758379e-08 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-501-3p KRAS 0.820141346319976 1.74562930463389e-08 -0.0421192166497262 0.67210141138451 MirTarget;PITA;TargetScan;miRNATAP -0.107029284719557 0.000261941382230982 NA NA NA hsa-miR-542-3p KRAS 0.643308814904977 8.81635403230104e-07 -0.0421192166497262 0.67210141138451 miRanda -0.137689698022332 2.50585208964673e-05 NA NA NA hsa-miR-30c-5p MAP2K1 0.021222006155897 0.886366656528128 0.142764606305617 0.0590440739007102 miRNAWalker2_validate -0.10505314483532 1.85439886243956e-06 NA NA NA hsa-miR-34a-5p MAP2K1 -0.117372471043915 0.364001947180738 0.142764606305617 0.0590440739007102 miRNAWalker2_validate;miRTarBase -0.123625149360131 1.05490001381872e-06 NA NA NA hsa-let-7b-5p MAP2K2 -0.2489842756826 0.0211384499461719 -0.140639001206001 0.11730805163915 miRNAWalker2_validate -0.227132527741912 2.24643017568319e-10 NA NA NA hsa-miR-130a-3p MAPK1 0.67051191119964 4.89747518735144e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.119879003954416 4.21355197025158e-07 NA NA NA hsa-miR-140-5p MAPK1 -0.412389003031485 0.000136051708543369 -0.0253189255173565 0.755655647597946 miRanda -0.106820947603036 0.00107357303022432 NA NA NA hsa-miR-16-2-3p MAPK1 1.1567130855258 1.01867256952189e-14 -0.0253189255173565 0.755655647597946 mirMAP -0.118882902026294 1.87389146405289e-07 NA NA NA hsa-miR-19a-3p MAPK1 1.35800152353624 2.80940447111944e-12 -0.0253189255173565 0.755655647597946 mirMAP -0.108060075233242 6.73894767696324e-10 NA NA NA hsa-miR-19b-3p MAPK1 0.538732279378089 0.000622008277870679 -0.0253189255173565 0.755655647597946 mirMAP -0.153151975431285 2.83628955522989e-12 NA NA NA hsa-miR-24-1-5p MAPK1 -0.0503110566834755 0.742860080224713 -0.0253189255173565 0.755655647597946 mirMAP -0.116961525723256 3.20301669196585e-07 NA NA NA hsa-miR-29a-5p MAPK1 0.323252792625584 0.0370417231222825 -0.0253189255173565 0.755655647597946 mirMAP -0.100820598289556 8.60387631678624e-06 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.502720326849742 0.000730448246894952 -0.0253189255173565 0.755655647597946 mirMAP -0.143966940664653 6.76991395724673e-10 NA NA NA hsa-miR-29b-3p MAPK1 -0.110721443686039 0.511264554091106 -0.0253189255173565 0.755655647597946 mirMAP -0.155562785937532 3.13794270245465e-14 NA NA NA hsa-miR-30b-5p MAPK1 -0.400238605368173 0.00346540992719245 -0.0253189255173565 0.755655647597946 mirMAP -0.174014396815711 6.15963591886978e-12 NA NA NA hsa-miR-30c-5p MAPK1 0.021222006155897 0.886366656528128 -0.0253189255173565 0.755655647597946 mirMAP -0.16816380351527 6.00043626518046e-13 NA NA NA hsa-miR-30d-3p MAPK1 -0.577371911152798 2.02950840095287e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.122142266216853 2.26778585246636e-05 NA NA NA hsa-miR-32-5p MAPK1 -0.317310201890053 0.0102525324475293 -0.0253189255173565 0.755655647597946 mirMAP -0.118206616474112 3.38014161673994e-05 NA NA NA hsa-miR-320a MAPK1 0.801356001806321 4.91397101474502e-09 -0.0253189255173565 0.755655647597946 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.125451646590753 6.80368047080733e-07 NA NA NA hsa-miR-338-3p MAPK1 -0.948755228846395 8.99167125682392e-08 -0.0253189255173565 0.755655647597946 miRanda -0.129835880343114 1.75257870680844e-11 NA NA NA hsa-miR-342-3p MAPK1 0.99756868977753 9.28499866272332e-10 -0.0253189255173565 0.755655647597946 miRanda;mirMAP -0.169189955454587 3.43413416819006e-16 NA NA NA hsa-miR-34a-5p MAPK1 -0.117372471043915 0.364001947180738 -0.0253189255173565 0.755655647597946 mirMAP -0.233668876576953 1.32503113597025e-18 NA NA NA hsa-miR-362-3p MAPK1 -0.697212068252854 2.61718493418184e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.110141441408008 2.93292282524057e-06 NA NA NA hsa-miR-362-5p MAPK1 0.41089772861323 0.0404254902071382 -0.0253189255173565 0.755655647597946 mirMAP -0.144103835470426 3.00694449777536e-17 NA NA NA hsa-miR-374a-3p MAPK1 -0.299190081500425 0.00682975596757891 -0.0253189255173565 0.755655647597946 mirMAP -0.110281311853038 0.000567634401408648 NA NA NA hsa-miR-374b-5p MAPK1 -0.288413933608091 0.0041474558664058 -0.0253189255173565 0.755655647597946 mirMAP -0.193539977082972 2.99670270207311e-08 NA NA NA hsa-miR-454-3p MAPK1 1.54137391927201 4.15861570449376e-20 -0.0253189255173565 0.755655647597946 mirMAP -0.134566799939584 1.33034028771569e-11 NA NA NA hsa-miR-500a-3p MAPK1 0.457959128173392 0.000691656736597067 -0.0253189255173565 0.755655647597946 mirMAP -0.181280312300052 1.44783347897454e-12 NA NA NA hsa-miR-501-3p MAPK1 0.820141346319976 1.74562930463389e-08 -0.0253189255173565 0.755655647597946 mirMAP -0.113690992046206 1.83281067549205e-06 NA NA NA hsa-miR-501-5p MAPK1 1.02806906860218 1.63456814370548e-09 -0.0253189255173565 0.755655647597946 mirMAP -0.102516454465174 5.70704874257852e-07 NA NA NA hsa-miR-502-3p MAPK1 -0.165138869760313 0.106881047403914 -0.0253189255173565 0.755655647597946 mirMAP -0.118442041096273 0.000641376645364786 NA NA NA hsa-miR-505-3p MAPK1 0.912823669571645 4.0549774967148e-13 -0.0253189255173565 0.755655647597946 mirMAP -0.112388892923579 4.07425901957411e-05 NA NA NA hsa-miR-660-5p MAPK1 -0.202705992887645 0.101093376073573 -0.0253189255173565 0.755655647597946 mirMAP -0.195287313401534 3.91978206929352e-12 NA NA NA hsa-let-7a-5p MAPK11 -0.439381775414001 3.1119785480023e-05 0.655585654068144 2.41371018464999e-06 miRNAWalker2_validate -0.230442250436062 6.64800124704327e-05 NA NA NA hsa-miR-140-3p MAPK11 -0.967453553824782 7.6999446305445e-23 0.655585654068144 2.41371018464999e-06 mirMAP -0.184846142335231 0.00205097804543975 NA NA NA hsa-miR-125a-3p MAPK13 0.116035800853173 0.444825559956959 -0.508562119880784 0.000695199481126942 miRanda -0.196155695894181 5.23442841481487e-06 NA NA NA hsa-miR-320a MAPK14 0.801356001806321 4.91397101474502e-09 -0.0956556568512745 0.173051538497392 PITA;miRanda -0.10567397029139 1.23981896330697e-06 NA NA NA hsa-miR-320b MAPK3 1.23473838180754 3.04337566045537e-14 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.150409382751881 7.4168687441981e-10 NA NA NA hsa-miR-34a-5p MAPK3 -0.117372471043915 0.364001947180738 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.142473103912921 8.01686085043296e-06 NA NA NA hsa-miR-423-3p MAPK3 1.20230884409188 2.57129723627633e-23 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.111095021124406 0.000694439178470412 NA NA NA hsa-miR-423-5p MAPK3 0.60141781325829 1.62940950644999e-07 -0.858383500175909 4.87731698141196e-21 miRNATAP -0.162814696094577 4.59419685322422e-06 NA NA NA hsa-miR-542-3p MAPK3 0.643308814904977 8.81635403230104e-07 -0.858383500175909 4.87731698141196e-21 miRanda -0.109224164762627 0.000481993746155519 NA NA NA hsa-miR-421 MAPKAPK3 0.945488088619653 2.35762398527362e-09 -1.16747097975825 3.34312421353914e-29 miRanda -0.105833325987805 0.000400151748502369 NA NA NA hsa-miR-429 MAPKAPK3 0.559451508722375 0.00563641638673083 -1.16747097975825 3.34312421353914e-29 miRNATAP -0.142555684847675 1.01426629753754e-09 NA NA NA hsa-miR-103a-3p NFAT5 0.556219385347418 1.55815736455067e-09 -0.144057691414319 0.161686730526662 MirTarget -0.207995109133484 1.54357973740012e-05 NA NA NA hsa-miR-106b-5p NFAT5 0.50378717276868 1.45412404526866e-05 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.146943934885414 0.000126283712364061 NA NA NA hsa-miR-1301-3p NFAT5 2.13677668481885 6.11093268540831e-44 -0.144057691414319 0.161686730526662 MirTarget -0.129391396030477 1.05453785272728e-06 NA NA NA hsa-miR-130b-5p NFAT5 1.77265255049999 1.43627774829684e-29 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.104785785454191 9.48430079345845e-05 NA NA NA hsa-miR-148b-5p NFAT5 1.1533193737265 7.26420964688337e-13 -0.144057691414319 0.161686730526662 MirTarget -0.123399922340603 6.83148615366435e-06 NA NA NA hsa-miR-155-5p NFAT5 0.533437622040649 0.00248671179205372 -0.144057691414319 0.161686730526662 mirMAP;miRNATAP -0.106013680019205 2.59274713106684e-05 NA NA NA hsa-miR-15a-5p NFAT5 0.783550182002274 2.60699595655907e-11 -0.144057691414319 0.161686730526662 MirTarget -0.260711437036921 1.40373282155601e-12 NA NA NA hsa-miR-15b-5p NFAT5 0.85315666454713 3.79816274836297e-12 -0.144057691414319 0.161686730526662 MirTarget -0.177225037397607 6.14884064260808e-07 NA NA NA hsa-miR-16-1-3p NFAT5 0.955017760172879 5.95379292601146e-11 -0.144057691414319 0.161686730526662 mirMAP -0.148358705172954 7.56510988061617e-07 NA NA NA hsa-miR-16-5p NFAT5 0.521122945828175 1.40561786410572e-06 -0.144057691414319 0.161686730526662 MirTarget -0.150153488582548 0.000270995641402817 NA NA NA hsa-miR-17-3p NFAT5 -0.0127974722290336 0.909559935689875 -0.144057691414319 0.161686730526662 mirMAP -0.103995928874833 0.00945096554302533 NA NA NA hsa-miR-17-5p NFAT5 1.41924888736771 2.75805544953758e-18 -0.144057691414319 0.161686730526662 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.112871620600036 2.01129819909764e-05 NA NA NA hsa-miR-181a-5p NFAT5 0.819060835827404 1.38616688310277e-13 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.131376826355535 0.000922051779412021 NA NA NA hsa-miR-181c-5p NFAT5 -0.168991199007857 0.196949106150297 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.110282026210921 0.00129921261744019 NA NA NA hsa-miR-186-5p NFAT5 0.353452958261612 0.000145058448579496 -0.144057691414319 0.161686730526662 MirTarget;mirMAP -0.151512954738844 0.00172600664640523 NA NA NA hsa-miR-194-5p NFAT5 -0.0214221838459805 0.872940154118701 -0.144057691414319 0.161686730526662 miRNATAP -0.14212968386338 2.1091843578297e-05 NA NA NA hsa-miR-20a-5p NFAT5 1.1531986665452 1.02385132917958e-11 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.134471280444853 1.5833816699071e-07 NA NA NA hsa-miR-21-5p NFAT5 1.62465922021121 3.44191300985109e-58 -0.144057691414319 0.161686730526662 miRNAWalker2_validate;mirMAP -0.120531670517944 0.0023816899097577 NA NA NA hsa-miR-25-3p NFAT5 0.76549796417801 3.32282098247097e-11 -0.144057691414319 0.161686730526662 miRNATAP -0.237976661388013 2.67168726188591e-10 NA NA NA hsa-miR-27b-5p NFAT5 0.580870079022649 0.000181529223377382 -0.144057691414319 0.161686730526662 miRNATAP -0.102951916376891 0.000330247866781112 NA NA NA hsa-miR-29b-3p NFAT5 -0.110721443686039 0.511264554091106 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.141278373568308 8.22455022993091e-08 NA NA NA hsa-miR-30b-5p NFAT5 -0.400238605368173 0.00346540992719245 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.171140961776254 1.27520967589192e-07 NA NA NA hsa-miR-30c-5p NFAT5 0.021222006155897 0.886366656528128 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.156091609992667 1.91266697905943e-07 NA NA NA hsa-miR-32-5p NFAT5 -0.317310201890053 0.0102525324475293 -0.144057691414319 0.161686730526662 miRNATAP -0.118779663579516 0.00105899276601224 NA NA NA hsa-miR-320a NFAT5 0.801356001806321 4.91397101474502e-09 -0.144057691414319 0.161686730526662 mirMAP -0.132185235411107 3.94733879649678e-05 NA NA NA hsa-miR-361-3p NFAT5 0.272298288982435 0.0147874880476998 -0.144057691414319 0.161686730526662 MirTarget;PITA;miRNATAP -0.157839364118843 8.40063732907985e-05 NA NA NA hsa-miR-3613-5p NFAT5 0.410363235348614 0.00534956684590092 -0.144057691414319 0.161686730526662 miRNATAP -0.109936859621761 0.000285754269138999 NA NA NA hsa-miR-362-5p NFAT5 0.41089772861323 0.0404254902071382 -0.144057691414319 0.161686730526662 mirMAP -0.149775556522558 7.85100591328312e-12 NA NA NA hsa-miR-374a-3p NFAT5 -0.299190081500425 0.00682975596757891 -0.144057691414319 0.161686730526662 mirMAP -0.202521314928992 5.1250260182258e-07 NA NA NA hsa-miR-374b-5p NFAT5 -0.288413933608091 0.0041474558664058 -0.144057691414319 0.161686730526662 mirMAP;miRNATAP -0.20861924136137 2.7371658700598e-06 NA NA NA hsa-miR-500a-3p NFAT5 0.457959128173392 0.000691656736597067 -0.144057691414319 0.161686730526662 MirTarget -0.197462156544802 1.53996978062261e-09 NA NA NA hsa-miR-500a-5p NFAT5 0.675401699376111 8.24389004707854e-05 -0.144057691414319 0.161686730526662 mirMAP -0.106589909918206 3.71675813942985e-05 NA NA NA hsa-miR-576-5p NFAT5 0.940432050128373 6.90227595663302e-12 -0.144057691414319 0.161686730526662 MirTarget;PITA;mirMAP -0.101572775536991 0.0015236056581376 NA NA NA hsa-miR-582-3p NFAT5 -0.248056267546012 0.143798829508405 -0.144057691414319 0.161686730526662 MirTarget -0.10043084390206 0.00013622400612072 NA NA NA hsa-miR-582-5p NFAT5 -0.0366995972742474 0.821827119138923 -0.144057691414319 0.161686730526662 MirTarget;PITA;miRNATAP -0.107169405369745 9.40426162612886e-05 NA NA NA hsa-miR-590-5p NFAT5 0.763025362395968 3.65305892505623e-09 -0.144057691414319 0.161686730526662 PITA;mirMAP;miRNATAP -0.121823622273204 0.000359647472614924 NA NA NA hsa-miR-664a-3p NFAT5 -0.256108763664991 0.0513188660751664 -0.144057691414319 0.161686730526662 MirTarget -0.128060886298548 0.000171135382086359 NA NA NA hsa-miR-92a-3p NFAT5 0.994679542307232 1.32587679156217e-16 -0.144057691414319 0.161686730526662 miRNATAP -0.156770819510124 1.39123614451506e-05 NA NA NA hsa-miR-93-5p NFAT5 1.61042951896619 5.1280369606967e-24 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.156016318591379 3.97583367554973e-09 NA NA NA hsa-miR-130b-5p NFATC2 1.77265255049999 1.43627774829684e-29 -1.25486248564221 0.000172992176354394 MirTarget -0.514289720906144 3.45340671629822e-09 NA NA NA hsa-miR-16-2-3p NFATC2 1.1567130855258 1.01867256952189e-14 -1.25486248564221 0.000172992176354394 mirMAP -0.657909202427149 2.22088975341719e-12 NA NA NA hsa-miR-182-5p NFATC2 1.15060905311096 6.25565852529946e-10 -1.25486248564221 0.000172992176354394 mirMAP -0.547097191091464 5.39311037502917e-13 NA NA NA hsa-miR-186-5p NFATC2 0.353452958261612 0.000145058448579496 -1.25486248564221 0.000172992176354394 mirMAP -0.737589937834061 2.75639363716297e-06 NA NA NA hsa-miR-19a-3p NFATC2 1.35800152353624 2.80940447111944e-12 -1.25486248564221 0.000172992176354394 mirMAP -0.924100758885834 3.58487812401573e-42 NA NA NA hsa-miR-19b-3p NFATC2 0.538732279378089 0.000622008277870679 -1.25486248564221 0.000172992176354394 mirMAP -1.15509771675492 1.64102640977043e-41 NA NA NA hsa-miR-205-3p NFATC2 1.2960640797621 5.80786479909147e-11 -1.25486248564221 0.000172992176354394 mirMAP -0.343866501621686 1.8468695557269e-06 NA NA NA hsa-miR-222-3p NFATC2 1.08197052578759 2.32604040301699e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.483064014402545 1.42535021555115e-06 NA NA NA hsa-miR-2355-3p NFATC2 1.58434563546762 4.06578912176206e-18 -1.25486248564221 0.000172992176354394 mirMAP -0.42812739127172 2.38490246638194e-08 NA NA NA hsa-miR-2355-5p NFATC2 1.47205546931107 8.65192179636668e-19 -1.25486248564221 0.000172992176354394 MirTarget -0.58837741374673 1.74879666791307e-12 NA NA NA hsa-miR-26b-3p NFATC2 0.421575313079363 0.00223298166810883 -1.25486248564221 0.000172992176354394 MirTarget -0.319217894210201 0.00264752852289272 NA NA NA hsa-miR-27b-5p NFATC2 0.580870079022649 0.000181529223377382 -1.25486248564221 0.000172992176354394 mirMAP -0.336293189286217 0.000339446551242512 NA NA NA hsa-miR-29a-5p NFATC2 0.323252792625584 0.0370417231222825 -1.25486248564221 0.000172992176354394 mirMAP;miRNATAP -0.544946324623055 5.46968828870313e-09 NA NA NA hsa-miR-30b-5p NFATC2 -0.400238605368173 0.00346540992719245 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.763262749165252 3.23713764040455e-13 NA NA NA hsa-miR-30c-5p NFATC2 0.021222006155897 0.886366656528128 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.819077629610369 1.45073885011096e-17 NA NA NA hsa-miR-31-3p NFATC2 2.10124531535908 1.70135756565194e-08 -1.25486248564221 0.000172992176354394 MirTarget -0.146949889334041 0.000140785099541377 NA NA NA hsa-miR-320a NFATC2 0.801356001806321 4.91397101474502e-09 -1.25486248564221 0.000172992176354394 MirTarget -0.59759720970056 1.06046391812254e-08 NA NA NA hsa-miR-320b NFATC2 1.23473838180754 3.04337566045537e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.301551217089888 0.000590783452269324 NA NA NA hsa-miR-335-3p NFATC2 0.336785882180547 0.0542446207938138 -1.25486248564221 0.000172992176354394 mirMAP -0.294498129578907 0.000424975091200581 NA NA NA hsa-miR-33a-3p NFATC2 0.20371038027126 0.212335697664505 -1.25486248564221 0.000172992176354394 mirMAP -0.245013497318194 0.00723337082303761 NA NA NA hsa-miR-3607-3p NFATC2 1.01377165357363 9.13355519701165e-05 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.349460391273266 2.66876725963668e-10 NA NA NA hsa-miR-3613-5p NFATC2 0.410363235348614 0.00534956684590092 -1.25486248564221 0.000172992176354394 mirMAP -0.608571808652233 5.28086151872216e-10 NA NA NA hsa-miR-484 NFATC2 0.918280909791707 1.39168306854263e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.479425009930687 6.21849237210953e-05 NA NA NA hsa-miR-7-1-3p NFATC2 1.13646121619622 1.49823237535933e-14 -1.25486248564221 0.000172992176354394 mirMAP -0.437536024803867 5.31776518083098e-06 NA NA NA hsa-miR-9-5p NFATC2 1.65694862043766 2.08325802567323e-05 -1.25486248564221 0.000172992176354394 MirTarget -0.188930767530834 3.12605846928591e-07 NA NA NA hsa-miR-15a-5p NFATC3 0.783550182002274 2.60699595655907e-11 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.23896463390166 3.19718683049365e-15 NA NA NA hsa-miR-29b-3p NFATC3 -0.110721443686039 0.511264554091106 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.16784148211833 5.77255843957477e-15 NA NA NA hsa-miR-30b-5p NFATC3 -0.400238605368173 0.00346540992719245 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.132557291878128 8.17457700322037e-07 NA NA NA hsa-miR-30c-5p NFATC3 0.021222006155897 0.886366656528128 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.119500911793098 1.55486386247615e-06 NA NA NA hsa-miR-339-5p NFATC3 1.07771430326938 2.45772601859307e-09 -0.122429472123375 0.151542167625529 miRanda -0.158684613876262 7.15220237478457e-16 NA NA NA hsa-miR-362-3p NFATC3 -0.697212068252854 2.61718493418184e-06 -0.122429472123375 0.151542167625529 miRanda -0.101516304611824 4.28696073128881e-05 NA NA NA hsa-miR-505-3p NFATC3 0.912823669571645 4.0549774967148e-13 -0.122429472123375 0.151542167625529 mirMAP -0.105028489202972 0.000269141405046069 NA NA NA hsa-miR-589-3p NFATC3 1.59559692667315 6.2886410639161e-15 -0.122429472123375 0.151542167625529 mirMAP -0.102849134107554 1.46704937520489e-08 NA NA NA hsa-miR-15b-3p NFATC4 1.05020782493504 6.38723677324836e-14 0.415879415068961 0.0231544563160674 mirMAP -0.308042115025679 2.37467711881828e-08 NA NA NA hsa-miR-193a-3p NFATC4 0.22120710726779 0.111827069464729 0.415879415068961 0.0231544563160674 miRanda -0.170575117609832 0.00306091588712347 NA NA NA hsa-miR-29a-3p NFATC4 -1.26881270980079 2.82496991513463e-22 0.415879415068961 0.0231544563160674 miRNATAP -0.159786866184639 0.00656637949012794 NA NA NA hsa-miR-429 NFATC4 0.559451508722375 0.00563641638673083 0.415879415068961 0.0231544563160674 miRNATAP -0.191470414872037 9.91379935744975e-07 NA NA NA hsa-miR-629-3p NFATC4 1.43262037314105 2.37092217984413e-19 0.415879415068961 0.0231544563160674 mirMAP -0.22273814727208 3.74632403524541e-06 NA NA NA hsa-miR-429 NOS3 0.559451508722375 0.00563641638673083 0.298346303074626 0.0796702739110418 miRanda -0.149004334883291 4.36466168709426e-05 NA NA NA hsa-miR-145-5p NRAS -0.46917511594055 0.000685297625493134 0.398384760345124 2.73206950817875e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.127512559718541 2.02648627117484e-05 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-195-3p NRAS -0.624259620429699 0.000164279659144497 0.398384760345124 2.73206950817875e-05 mirMAP -0.105599176842807 2.41335123569666e-05 NA NA NA hsa-miR-26b-5p NRAS -0.254478038884324 0.0285227763044636 0.398384760345124 2.73206950817875e-05 mirMAP;miRNATAP -0.118342937472199 0.000985220833353607 NA NA NA hsa-miR-29b-3p NRAS -0.110721443686039 0.511264554091106 0.398384760345124 2.73206950817875e-05 miRNATAP -0.115340209430372 2.64204854445589e-06 NA NA NA hsa-miR-30e-3p NRAS -0.890635378639789 1.65740480611339e-16 0.398384760345124 2.73206950817875e-05 mirMAP -0.108551838334895 0.00387728250241298 NA NA NA hsa-miR-374a-3p NRAS -0.299190081500425 0.00682975596757891 0.398384760345124 2.73206950817875e-05 miRNATAP -0.154068780755208 4.21664914129326e-05 NA NA NA hsa-miR-374a-5p NRAS -0.621903385111545 6.61791773205282e-12 0.398384760345124 2.73206950817875e-05 mirMAP -0.130523090756999 0.00410722859636246 NA NA NA hsa-miR-374b-5p NRAS -0.288413933608091 0.0041474558664058 0.398384760345124 2.73206950817875e-05 mirMAP -0.269889320734344 4.1936925860835e-11 NA NA NA hsa-miR-664a-3p NRAS -0.256108763664991 0.0513188660751664 0.398384760345124 2.73206950817875e-05 MirTarget -0.25886236854543 4.55022879480367e-17 NA NA NA hsa-miR-146b-5p PIK3CA 0.917975986853978 3.33749259316025e-09 0.474083948253385 0.000138354293457267 mirMAP -0.148623698754488 1.59224953432472e-05 NA NA NA hsa-miR-17-5p PIK3CA 1.41924888736771 2.75805544953758e-18 0.474083948253385 0.000138354293457267 miRNAWalker2_validate -0.121128691188414 0.000174670602072176 NA NA NA hsa-miR-186-5p PIK3CA 0.353452958261612 0.000145058448579496 0.474083948253385 0.000138354293457267 mirMAP -0.297473635549502 3.47602075640407e-07 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.39669186711325 4.36960953138935e-11 0.474083948253385 0.000138354293457267 mirMAP -0.137606426566373 3.59722935161776e-08 NA NA NA hsa-miR-320a PIK3CA 0.801356001806321 4.91397101474502e-09 0.474083948253385 0.000138354293457267 miRanda -0.175899873415021 6.70887782534591e-06 NA NA NA hsa-miR-339-5p PIK3CA 1.07771430326938 2.45772601859307e-09 0.474083948253385 0.000138354293457267 miRanda -0.140087795917754 2.01352800438963e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.288413933608091 0.0041474558664058 0.474083948253385 0.000138354293457267 mirMAP -0.251699909641235 3.33151190183606e-06 NA NA NA hsa-miR-501-5p PIK3CA 1.02806906860218 1.63456814370548e-09 0.474083948253385 0.000138354293457267 mirMAP -0.119863788285527 0.00016396438241956 NA NA NA hsa-miR-576-5p PIK3CA 0.940432050128373 6.90227595663302e-12 0.474083948253385 0.000138354293457267 PITA -0.211172584428942 4.54724446596707e-08 NA NA NA hsa-miR-582-3p PIK3CA -0.248056267546012 0.143798829508405 0.474083948253385 0.000138354293457267 miRNATAP -0.112384075179319 0.000457171976884077 NA NA NA hsa-miR-590-3p PIK3CA 0.221436901462551 0.0965904764063157 0.474083948253385 0.000138354293457267 miRanda;mirMAP -0.123785866799948 0.00253231685417896 NA NA NA hsa-miR-590-5p PIK3CA 0.763025362395968 3.65305892505623e-09 0.474083948253385 0.000138354293457267 miRanda -0.137459565446424 0.000946581823458912 NA NA NA hsa-miR-130a-3p PIK3CB 0.67051191119964 4.89747518735144e-06 -0.0830016803916331 0.377605728994098 miRNATAP -0.116910694940516 2.17993945184649e-05 NA NA NA hsa-miR-455-5p PIK3CB 1.408595672323 5.52039116456697e-22 -0.0830016803916331 0.377605728994098 miRNATAP -0.112305249746916 2.65965267643942e-05 NA NA NA hsa-miR-1468-5p PIK3CD -1.11814152104975 9.8203170781489e-10 1.09936669850841 6.53933580961931e-14 MirTarget -0.190058878065479 5.39186071979921e-08 NA NA NA hsa-miR-199a-5p PIK3CD -0.364835768178638 0.0435119211101981 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.10392905863127 0.00413232021656056 NA NA NA hsa-miR-199b-5p PIK3CD -1.08432682485992 7.68241801134089e-10 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.174865940346935 1.46520648745166e-06 NA NA NA hsa-miR-29c-3p PIK3CD -2.08166260448948 8.3238369390898e-24 1.09936669850841 6.53933580961931e-14 mirMAP -0.123728555182124 3.91761687692399e-05 NA NA NA hsa-miR-30a-5p PIK3CD -1.79779915425811 1.93360169837799e-26 1.09936669850841 6.53933580961931e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.215181764255274 3.32715363881856e-09 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -0.338530747940815 0.0223424741180399 1.09936669850841 6.53933580961931e-14 MirTarget -0.212653512510377 1.36776424072036e-06 NA NA NA hsa-miR-30b-5p PIK3CD -0.400238605368173 0.00346540992719245 1.09936669850841 6.53933580961931e-14 MirTarget -0.248889126985861 1.5426059915817e-07 NA NA NA hsa-miR-30d-5p PIK3CD -0.38399848121878 0.000171129616944749 1.09936669850841 6.53933580961931e-14 MirTarget;miRNATAP -0.328266173808776 2.63776877258142e-07 NA NA NA hsa-miR-30e-5p PIK3CD -1.02114836019762 6.81961221797866e-17 1.09936669850841 6.53933580961931e-14 MirTarget -0.209324939899388 5.5934958220938e-05 NA NA NA hsa-miR-126-3p PIK3CG 0.0487843863772834 0.730130847436008 0.00752271010659966 0.976960758681749 miRTarBase -0.269414114814437 0.000806379873030215 NA NA NA hsa-miR-26b-5p PIK3CG -0.254478038884324 0.0285227763044636 0.00752271010659966 0.976960758681749 miRNAWalker2_validate -0.345718989912845 0.00041292580999725 NA NA NA hsa-miR-335-3p PIK3CG 0.336785882180547 0.0542446207938138 0.00752271010659966 0.976960758681749 mirMAP -0.20863783184887 0.00127495716846541 NA NA NA hsa-miR-3607-3p PIK3CG 1.01377165357363 9.13355519701165e-05 0.00752271010659966 0.976960758681749 mirMAP -0.153979618634459 0.000387199003031277 NA NA NA hsa-miR-103a-3p PIK3R1 0.556219385347418 1.55815736455067e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.399035342845615 3.61390305129075e-07 NA NA NA hsa-miR-1301-3p PIK3R1 2.13677668481885 6.11093268540831e-44 -1.21900359295309 1.01203266762174e-13 MirTarget -0.223004793710498 2.5912949051374e-07 NA NA NA hsa-miR-15a-5p PIK3R1 0.783550182002274 2.60699595655907e-11 -1.21900359295309 1.01203266762174e-13 MirTarget -0.385662977903284 1.7816116353762e-10 NA NA NA hsa-miR-15b-5p PIK3R1 0.85315666454713 3.79816274836297e-12 -1.21900359295309 1.01203266762174e-13 MirTarget -0.228618884263194 9.01523017331239e-05 NA NA NA hsa-miR-16-2-3p PIK3R1 1.1567130855258 1.01867256952189e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.316425483424084 1.52783996282521e-11 NA NA NA hsa-miR-17-5p PIK3R1 1.41924888736771 2.75805544953758e-18 -1.21900359295309 1.01203266762174e-13 MirTarget;TargetScan;miRNATAP -0.463182517340129 2.13936557580788e-29 NA NA NA hsa-miR-182-5p PIK3R1 1.15060905311096 6.25565852529946e-10 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.244940881967473 1.25505363832818e-10 NA NA NA hsa-miR-185-5p PIK3R1 0.675225177054909 1.84953949190805e-13 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.284475955115523 0.000292942961891748 NA NA NA hsa-miR-186-5p PIK3R1 0.353452958261612 0.000145058448579496 -1.21900359295309 1.01203266762174e-13 mirMAP -0.319700116089251 4.98623038012755e-05 NA NA NA hsa-miR-188-5p PIK3R1 0.559328953885106 0.000430338888594543 -1.21900359295309 1.01203266762174e-13 MirTarget -0.160342440576419 0.000495444736297818 NA NA NA hsa-miR-200b-3p PIK3R1 0.0717138787925347 0.682858087587209 -1.21900359295309 1.01203266762174e-13 mirMAP -0.132316541375546 0.00152319590606084 NA NA NA hsa-miR-200c-3p PIK3R1 0.630251054099546 0.000131975031451555 -1.21900359295309 1.01203266762174e-13 mirMAP -0.165950070298812 0.000166005249225027 NA NA NA hsa-miR-20a-5p PIK3R1 1.1531986665452 1.02385132917958e-11 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.414035689070749 1.37700726304578e-24 NA NA NA hsa-miR-21-5p PIK3R1 1.62465922021121 3.44191300985109e-58 -1.21900359295309 1.01203266762174e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.347959293536401 6.14239978504788e-08 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.706731861922839 3.44318705980007e-07 -1.21900359295309 1.01203266762174e-13 mirMAP -0.186341013334501 0.000362689778770643 NA NA NA hsa-miR-222-3p PIK3R1 1.08197052578759 2.32604040301699e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.324361920211689 6.16230355082933e-11 NA NA NA hsa-miR-224-3p PIK3R1 0.502645536188015 0.0081142387260641 -1.21900359295309 1.01203266762174e-13 mirMAP -0.120566945623901 0.00184832047796862 NA NA NA hsa-miR-29b-3p PIK3R1 -0.110721443686039 0.511264554091106 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.121645516169564 0.00518596779631768 NA NA NA hsa-miR-320a PIK3R1 0.801356001806321 4.91397101474502e-09 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.225199809648846 1.82460995490226e-05 NA NA NA hsa-miR-320b PIK3R1 1.23473838180754 3.04337566045537e-14 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.134920857869101 0.00211752860446172 NA NA NA hsa-miR-324-3p PIK3R1 0.867391246413545 3.63808540490361e-10 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.177541714088148 0.000648957139596168 NA NA NA hsa-miR-424-5p PIK3R1 1.48125289532143 9.10372985713165e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.194732317900543 3.45343462326547e-06 NA NA NA hsa-miR-429 PIK3R1 0.559451508722375 0.00563641638673083 -1.21900359295309 1.01203266762174e-13 mirMAP;miRNATAP -0.216477715044302 1.22729945836841e-09 NA NA NA hsa-miR-450b-5p PIK3R1 1.25529820885833 1.18847120528666e-15 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.182288230735551 5.59609717066614e-05 NA NA NA hsa-miR-455-3p PIK3R1 2.68574446868387 4.28975903022818e-42 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.231037194203872 4.67534308068801e-12 NA NA NA hsa-miR-584-5p PIK3R1 0.458655788667031 0.0421764547676754 -1.21900359295309 1.01203266762174e-13 mirMAP -0.158511510137748 8.00515680759562e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.59559692667315 6.2886410639161e-15 -1.21900359295309 1.01203266762174e-13 mirMAP -0.276889190811914 4.76785574986701e-15 NA NA NA hsa-miR-590-3p PIK3R1 0.221436901462551 0.0965904764063157 -1.21900359295309 1.01203266762174e-13 miRanda;mirMAP -0.158050349961081 0.00414021352655968 NA NA NA hsa-miR-590-5p PIK3R1 0.763025362395968 3.65305892505623e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRanda;miRNATAP -0.424270969807281 7.70480985025408e-15 NA NA NA hsa-miR-629-3p PIK3R1 1.43262037314105 2.37092217984413e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.192452582760208 1.31715256298262e-05 NA NA NA hsa-miR-93-5p PIK3R1 1.61042951896619 5.1280369606967e-24 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.348791344759735 3.1302460531533e-16 NA NA NA hsa-miR-96-5p PIK3R1 1.42326703011157 4.39736150032373e-14 -1.21900359295309 1.01203266762174e-13 TargetScan;miRNATAP -0.310953673912161 2.47412618125618e-17 NA NA NA hsa-miR-18a-3p PIK3R3 1.82583720936229 7.51297960972179e-19 -0.129019532966171 0.451055967559973 miRNAWalker2_validate -0.103240638013552 0.00398585116122596 NA NA NA hsa-miR-19a-3p PIK3R3 1.35800152353624 2.80940447111944e-12 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.153374017381767 4.01568767526052e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.538732279378089 0.000622008277870679 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.12996294371586 0.00591308278368021 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.39669186711325 4.36960953138935e-11 -0.129019532966171 0.451055967559973 mirMAP -0.137442753028623 6.48468495867568e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.446833934952926 0.00233857759218299 -0.129019532966171 0.451055967559973 MirTarget -0.431569400997508 1.46400297130903e-18 NA NA NA hsa-miR-369-3p PIK3R3 -1.2344419076994 2.66882944171146e-10 -0.129019532966171 0.451055967559973 PITA -0.105890967034452 0.00482950119317686 NA NA NA hsa-miR-589-3p PIK3R3 1.59559692667315 6.2886410639161e-15 -0.129019532966171 0.451055967559973 mirMAP -0.138465461387875 0.000168219132587265 NA NA NA hsa-miR-182-5p PIK3R5 1.15060905311096 6.25565852529946e-10 0.15902332125267 0.38685549407615 MirTarget -0.236115638976413 1.63099014479463e-08 NA NA NA hsa-miR-18a-3p PIK3R5 1.82583720936229 7.51297960972179e-19 0.15902332125267 0.38685549407615 MirTarget -0.160296162742907 2.89078394864452e-05 NA NA NA hsa-miR-944 PIK3R5 1.47323925060177 2.61626403984929e-13 0.15902332125267 0.38685549407615 mirMAP -0.211607874388069 3.42384043348289e-08 NA NA NA hsa-miR-106b-5p PLA2G12A 0.50378717276868 1.45412404526866e-05 -0.773329107391423 2.43200915974282e-25 mirMAP -0.113152221403065 9.71366002804154e-05 NA NA NA hsa-miR-142-3p PLA2G12A 1.12754191614028 1.68798138028946e-08 -0.773329107391423 2.43200915974282e-25 miRanda -0.104413909705145 2.31791164239698e-10 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.1567130855258 1.01867256952189e-14 -0.773329107391423 2.43200915974282e-25 mirMAP -0.127091654598804 6.02628463819818e-09 NA NA NA hsa-miR-181a-5p PLA2G12A 0.819060835827404 1.38616688310277e-13 -0.773329107391423 2.43200915974282e-25 mirMAP -0.177084446294844 2.45134089240318e-09 NA NA NA hsa-miR-181b-5p PLA2G12A 0.974255518824355 2.64876280203475e-16 -0.773329107391423 2.43200915974282e-25 mirMAP -0.16275276376844 2.98535886245717e-09 NA NA NA hsa-miR-625-3p PLA2G12A 0.0858338965684338 0.484971431380441 -0.773329107391423 2.43200915974282e-25 mirMAP -0.126989161560015 4.13953749944208e-06 NA NA NA hsa-miR-361-5p PLA2G2A 0.0803683277369505 0.314043140368058 -5.07596668469226 1.66171761681806e-23 miRanda -0.781056988805095 0.00829293149597172 NA NA NA hsa-miR-338-3p PLA2G2D -0.948755228846395 8.99167125682392e-08 1.06272215329204 0.0205348409418983 mirMAP -0.459956147027393 3.45885213943891e-05 NA NA NA hsa-miR-432-5p PLA2G2D -1.37745409934142 1.95995628572162e-09 1.06272215329204 0.0205348409418983 mirMAP -0.321939313285914 0.000173473611383924 NA NA NA hsa-miR-542-3p PLA2G2D 0.643308814904977 8.81635403230104e-07 1.06272215329204 0.0205348409418983 mirMAP -0.424558686560124 0.00526558318994375 NA NA NA hsa-miR-107 PLA2G2F -0.0447040564279497 0.671618791096755 2.39159167905521 3.03321604447909e-06 miRNATAP -1.22281290549308 9.80852928367302e-09 NA NA NA hsa-miR-125b-5p PLA2G2F -0.993460109818276 5.07736727659894e-12 2.39159167905521 3.03321604447909e-06 mirMAP -1.07055494180228 1.2079180661789e-12 NA NA NA hsa-miR-219a-1-3p PLA2G2F 0.54812960890496 0.000643480374673536 2.39159167905521 3.03321604447909e-06 MirTarget -0.816812716298986 3.53248750025489e-09 NA NA NA hsa-miR-296-5p PLA2G2F -0.425442682383961 0.0948240114267711 2.39159167905521 3.03321604447909e-06 mirMAP -0.40234344693344 7.84747912448152e-06 NA NA NA hsa-miR-324-3p PLA2G2F 0.867391246413545 3.63808540490361e-10 2.39159167905521 3.03321604447909e-06 mirMAP -0.722884962070708 5.97679176707774e-06 NA NA NA hsa-miR-326 PLA2G2F -0.425943992128769 0.0415010315530797 2.39159167905521 3.03321604447909e-06 mirMAP -0.292944760152887 0.00680257166363506 NA NA NA hsa-miR-335-5p PLA2G2F -1.17227779671552 1.49282618530733e-10 2.39159167905521 3.03321604447909e-06 mirMAP -0.745274230846876 4.10351967835558e-10 NA NA NA hsa-miR-532-5p PLA2G2F -0.021857649390892 0.830992272120134 2.39159167905521 3.03321604447909e-06 mirMAP -0.982413216365621 8.88844541055468e-06 NA NA NA hsa-let-7d-5p PLA2G3 0.481757661442508 3.66030810124939e-07 -1.55144754456764 0.000892530659625258 MirTarget -0.791725977061563 0.000234227869408305 NA NA NA hsa-let-7e-5p PLA2G3 0.0857356192778891 0.512869729833211 -1.55144754456764 0.000892530659625258 MirTarget -0.954528348111551 6.67534191858455e-10 NA NA NA hsa-let-7i-5p PLA2G3 0.249440992451337 0.00426823922424972 -1.55144754456764 0.000892530659625258 MirTarget -0.634764626341883 0.00737002608471883 NA NA NA hsa-miR-125a-3p PLA2G3 0.116035800853173 0.444825559956959 -1.55144754456764 0.000892530659625258 miRanda;miRNATAP -0.629027586265024 2.74387066358586e-06 NA NA NA hsa-miR-214-3p PLA2G3 -0.118240959890965 0.564962359782563 -1.55144754456764 0.000892530659625258 MirTarget -0.318860501519846 0.00137931064400643 NA NA NA hsa-miR-323a-3p PLA2G3 0.554923914792824 0.00856909375866133 -1.55144754456764 0.000892530659625258 MirTarget -0.453421691338451 3.55310724475585e-06 NA NA NA hsa-miR-450b-5p PLA2G3 1.25529820885833 1.18847120528666e-15 -1.55144754456764 0.000892530659625258 miRNATAP -0.797130129847432 1.75318622944739e-10 NA NA NA hsa-miR-877-5p PLA2G3 1.97571572671705 2.0032239372269e-19 -1.55144754456764 0.000892530659625258 MirTarget -0.394189129388487 4.50358237517234e-05 NA NA NA hsa-miR-146b-5p PLA2G4A 0.917975986853978 3.33749259316025e-09 -0.460609969941168 0.089725403121305 miRNAWalker2_validate -0.312706384274956 2.97197899139276e-05 NA NA NA hsa-miR-181a-5p PLA2G4A 0.819060835827404 1.38616688310277e-13 -0.460609969941168 0.089725403121305 MirTarget -0.343622076779683 0.00104992726574145 NA NA NA hsa-miR-181b-5p PLA2G4A 0.974255518824355 2.64876280203475e-16 -0.460609969941168 0.089725403121305 MirTarget -0.301620745034892 0.00186067356352167 NA NA NA hsa-miR-432-5p PLA2G4E -1.37745409934142 1.95995628572162e-09 0.42032711661257 0.3709136444725 mirMAP -0.263208864952446 0.00272460058896533 NA NA NA hsa-miR-664a-3p PLA2G4E -0.256108763664991 0.0513188660751664 0.42032711661257 0.3709136444725 mirMAP -0.826986198627894 9.10088489695046e-08 NA NA NA hsa-miR-330-5p PLA2G5 0.944693925383906 5.04972895657346e-13 -0.467636358747842 0.0620719799293586 miRanda -0.257302280936903 0.00167841807610569 NA NA NA hsa-miR-339-5p PLA2G5 1.07771430326938 2.45772601859307e-09 -0.467636358747842 0.0620719799293586 miRanda -0.268456976521455 5.82075902949895e-06 NA NA NA hsa-miR-429 PLA2G5 0.559451508722375 0.00563641638673083 -0.467636358747842 0.0620719799293586 miRanda -0.290029978513431 5.55947010592671e-08 NA NA NA hsa-miR-589-3p PLA2G5 1.59559692667315 6.2886410639161e-15 -0.467636358747842 0.0620719799293586 MirTarget -0.19760724002258 0.000253067536702086 NA NA NA hsa-miR-590-3p PLA2G5 0.221436901462551 0.0965904764063157 -0.467636358747842 0.0620719799293586 miRanda;miRNATAP -0.271782372358567 0.000946830763546805 NA NA NA hsa-miR-590-5p PLA2G5 0.763025362395968 3.65305892505623e-09 -0.467636358747842 0.0620719799293586 miRanda -0.438011814247796 1.21396823094669e-07 NA NA NA hsa-miR-185-3p PLA2G6 0.653637407906201 6.54212996668668e-05 -0.1388448067516 0.262127145301077 MirTarget -0.101887125819572 0.00185902800489636 NA NA NA hsa-miR-2355-3p PLA2G6 1.58434563546762 4.06578912176206e-18 -0.1388448067516 0.262127145301077 MirTarget -0.168200890698393 2.27529266289357e-09 NA NA NA hsa-miR-101-3p PLCG1 -1.91263766544878 1.50270129259053e-39 0.71662591280652 5.64973900982125e-20 miRNATAP -0.151553337202427 6.92128262971549e-12 NA NA NA hsa-miR-200b-3p PLCG1 0.0717138787925347 0.682858087587209 0.71662591280652 5.64973900982125e-20 TargetScan -0.102140424719201 3.23461890512312e-07 NA NA NA hsa-miR-34a-5p PLCG1 -0.117372471043915 0.364001947180738 0.71662591280652 5.64973900982125e-20 miRNAWalker2_validate;miRNATAP -0.10103184513093 0.000225366609484434 NA NA NA hsa-miR-125a-5p PLCG2 0.215366061934933 0.119550904549401 0.466254496043281 0.000532825814091435 miRanda -0.114996767575978 0.00709893512710981 NA NA NA hsa-let-7g-5p PPP3CA -0.250780249469264 0.00939610188330072 0.0261166441094005 0.774380327390763 miRNATAP -0.129044274233211 0.00176768769369972 NA NA NA hsa-miR-17-5p PPP3CA 1.41924888736771 2.75805544953758e-18 0.0261166441094005 0.774380327390763 miRNATAP -0.107154786794133 4.49246161780872e-06 NA NA NA hsa-miR-186-5p PPP3CA 0.353452958261612 0.000145058448579496 0.0261166441094005 0.774380327390763 mirMAP -0.119442984122439 0.00521905941342711 NA NA NA hsa-miR-194-5p PPP3CA -0.0214221838459805 0.872940154118701 0.0261166441094005 0.774380327390763 MirTarget -0.227106380168213 4.11707254283389e-15 NA NA NA hsa-miR-20a-5p PPP3CA 1.1531986665452 1.02385132917958e-11 0.0261166441094005 0.774380327390763 miRNATAP -0.135937480891387 1.71175203332467e-09 NA NA NA hsa-miR-30c-5p PPP3CA 0.021222006155897 0.886366656528128 0.0261166441094005 0.774380327390763 miRNATAP -0.138568670147619 1.67033051966156e-07 NA NA NA hsa-miR-30d-5p PPP3CA -0.38399848121878 0.000171129616944749 0.0261166441094005 0.774380327390763 miRNATAP -0.103928901064269 0.00747324777039719 NA NA NA hsa-miR-361-3p PPP3CA 0.272298288982435 0.0147874880476998 0.0261166441094005 0.774380327390763 MirTarget;PITA;miRNATAP -0.147461540913571 3.1572107642519e-05 NA NA NA hsa-miR-590-3p PPP3CA 0.221436901462551 0.0965904764063157 0.0261166441094005 0.774380327390763 miRanda;mirMAP -0.1292662240092 1.28492091373993e-05 NA NA NA hsa-miR-590-5p PPP3CA 0.763025362395968 3.65305892505623e-09 0.0261166441094005 0.774380327390763 PITA;miRanda;miRNATAP -0.130608084993601 1.4121892378982e-05 NA NA NA hsa-miR-664a-3p PPP3CA -0.256108763664991 0.0513188660751664 0.0261166441094005 0.774380327390763 mirMAP -0.154862721187903 2.28408619679922e-07 NA NA NA hsa-miR-7-1-3p PPP3CA 1.13646121619622 1.49823237535933e-14 0.0261166441094005 0.774380327390763 MirTarget;mirMAP -0.113744929124115 1.18665245144482e-05 NA NA NA hsa-miR-93-5p PPP3CA 1.61042951896619 5.1280369606967e-24 0.0261166441094005 0.774380327390763 miRNATAP -0.134887598190219 8.69707313946358e-09 NA NA NA hsa-miR-96-5p PPP3CA 1.42326703011157 4.39736150032373e-14 0.0261166441094005 0.774380327390763 TargetScan -0.105360576077386 1.99204409171748e-07 NA NA NA hsa-miR-15b-5p PPP3CB 0.85315666454713 3.79816274836297e-12 -0.430650123435909 1.6653183674225e-09 miRNATAP -0.147896038786253 2.77153942258358e-09 NA NA NA hsa-miR-361-5p PPP3CB 0.0803683277369505 0.314043140368058 -0.430650123435909 1.6653183674225e-09 miRanda -0.146324240065503 0.000258725360624939 NA NA NA hsa-miR-429 PPP3CB 0.559451508722375 0.00563641638673083 -0.430650123435909 1.6653183674225e-09 miRanda -0.126839398598655 4.12587575752935e-17 NA NA NA hsa-miR-103a-2-5p PRKCA 1.37988337975616 6.74852943995612e-08 0.3178322857115 0.0462170958036427 mirMAP -0.117780407567177 5.24493745308123e-05 NA NA NA hsa-miR-150-5p PRKCA -0.243749814009231 0.331546276920338 0.3178322857115 0.0462170958036427 mirMAP -0.104022182991935 0.000162874861270433 NA NA NA hsa-miR-17-3p PRKCA -0.0127974722290336 0.909559935689875 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.214761659225552 0.000540115676811066 NA NA NA hsa-miR-181c-5p PRKCA -0.168991199007857 0.196949106150297 0.3178322857115 0.0462170958036427 mirMAP -0.230481828890932 1.38543638100701e-05 NA NA NA hsa-miR-183-5p PRKCA 1.4313129319945 6.25230916431996e-14 0.3178322857115 0.0462170958036427 miRNATAP -0.123604672252822 0.000489233186271866 NA NA NA hsa-miR-186-5p PRKCA 0.353452958261612 0.000145058448579496 0.3178322857115 0.0462170958036427 miRNATAP -0.197395594611936 0.008653002308399 NA NA NA hsa-miR-1976 PRKCA 0.638808083289405 2.94840228896364e-07 0.3178322857115 0.0462170958036427 miRNATAP -0.216146135639291 9.07994360436659e-05 NA NA NA hsa-miR-19b-1-5p PRKCA 0.757034032029085 2.99828133413343e-07 0.3178322857115 0.0462170958036427 mirMAP -0.214408086876696 3.69042545103291e-06 NA NA NA hsa-miR-200b-3p PRKCA 0.0717138787925347 0.682858087587209 0.3178322857115 0.0462170958036427 TargetScan -0.341691724440131 5.17210999735547e-19 NA NA NA hsa-miR-200c-3p PRKCA 0.630251054099546 0.000131975031451555 0.3178322857115 0.0462170958036427 miRNATAP -0.258050454876613 4.38353493232271e-10 NA NA NA hsa-miR-24-2-5p PRKCA 1.27293931700635 4.48240091510596e-15 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.121435567912037 0.00357611288622236 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.580870079022649 0.000181529223377382 0.3178322857115 0.0462170958036427 mirMAP -0.227514723686497 2.70991772299128e-07 NA NA NA hsa-miR-29b-2-5p PRKCA -0.502720326849742 0.000730448246894952 0.3178322857115 0.0462170958036427 mirMAP -0.296683337612196 9.93635847649949e-11 NA NA NA hsa-miR-30d-3p PRKCA -0.577371911152798 2.02950840095287e-06 0.3178322857115 0.0462170958036427 mirMAP -0.332961077885486 3.40360771990262e-09 NA NA NA hsa-miR-30e-3p PRKCA -0.890635378639789 1.65740480611339e-16 0.3178322857115 0.0462170958036427 mirMAP -0.199675307499267 0.00146746163627339 NA NA NA hsa-miR-339-5p PRKCA 1.07771430326938 2.45772601859307e-09 0.3178322857115 0.0462170958036427 mirMAP -0.148559462896231 8.30706937469769e-05 NA NA NA hsa-miR-3607-3p PRKCA 1.01377165357363 9.13355519701165e-05 0.3178322857115 0.0462170958036427 mirMAP -0.133480273866349 4.39877789751401e-07 NA NA NA hsa-miR-362-5p PRKCA 0.41089772861323 0.0404254902071382 0.3178322857115 0.0462170958036427 TargetScan;miRNATAP -0.223333590994173 5.47462768229892e-11 NA NA NA hsa-miR-374a-5p PRKCA -0.621903385111545 6.61791773205282e-12 0.3178322857115 0.0462170958036427 mirMAP -0.205530215602705 0.00688190144820459 NA NA NA hsa-miR-429 PRKCA 0.559451508722375 0.00563641638673083 0.3178322857115 0.0462170958036427 miRanda;miRNATAP -0.266671632635371 1.42360916592268e-15 NA NA NA hsa-miR-500a-5p PRKCA 0.675401699376111 8.24389004707854e-05 0.3178322857115 0.0462170958036427 miRNATAP -0.174713694092824 1.31490069031191e-05 NA NA NA hsa-miR-501-5p PRKCA 1.02806906860218 1.63456814370548e-09 0.3178322857115 0.0462170958036427 miRNATAP -0.164099616970046 5.18294254195767e-05 NA NA NA hsa-miR-505-5p PRKCA 1.25888458076414 7.80089782306577e-13 0.3178322857115 0.0462170958036427 mirMAP -0.108990500629565 0.00483820175668253 NA NA NA hsa-miR-532-3p PRKCA 0.80240056676907 1.08989551712617e-09 0.3178322857115 0.0462170958036427 mirMAP;miRNATAP -0.201724862387695 0.000103690896052721 NA NA NA hsa-miR-590-3p PRKCA 0.221436901462551 0.0965904764063157 0.3178322857115 0.0462170958036427 PITA;miRanda;mirMAP;miRNATAP -0.159630241178647 0.00227859309388304 NA NA NA hsa-miR-92a-3p PRKCA 0.994679542307232 1.32587679156217e-16 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.239077901540622 1.99085302915519e-05 NA NA NA hsa-miR-93-3p PRKCA 1.69225547123293 1.50964095575087e-25 0.3178322857115 0.0462170958036427 mirMAP -0.142996896050503 0.000455152507074917 NA NA NA hsa-miR-200b-3p PRKCB 0.0717138787925347 0.682858087587209 -0.00995382054367333 0.966062170170983 MirTarget -0.25314056822959 1.19976246306159e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.630251054099546 0.000131975031451555 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.247883706249509 5.19535947946646e-05 NA NA NA hsa-miR-205-3p PRKCB 1.2960640797621 5.80786479909147e-11 -0.00995382054367333 0.966062170170983 mirMAP -0.139761356797048 0.00563704149985681 NA NA NA hsa-miR-23a-3p PRKCB 0.348231698801568 6.4911858506572e-05 -0.00995382054367333 0.966062170170983 mirMAP -0.585222638829513 5.31039580277569e-07 NA NA NA hsa-miR-24-3p PRKCB 0.13115428390042 0.203891651275156 -0.00995382054367333 0.966062170170983 miRNATAP -0.412248047896016 3.20409690969774e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.348456440505425 0.00126682892514312 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.586533342240413 3.06369418405208e-10 NA NA NA hsa-miR-335-3p PRKCB 0.336785882180547 0.0542446207938138 -0.00995382054367333 0.966062170170983 mirMAP -0.150801933292581 0.00964223317290781 NA NA NA hsa-miR-338-3p PRKCB -0.948755228846395 8.99167125682392e-08 -0.00995382054367333 0.966062170170983 miRanda -0.189063660103368 0.000843153123017634 NA NA NA hsa-miR-361-5p PRKCB 0.0803683277369505 0.314043140368058 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.375874177784515 0.00379764519521529 NA NA NA hsa-miR-429 PRKCB 0.559451508722375 0.00563641638673083 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.30122694602295 1.22808222979422e-09 NA NA NA hsa-miR-450b-5p PRKCB 1.25529820885833 1.18847120528666e-15 -0.00995382054367333 0.966062170170983 miRNATAP -0.164181125995606 0.00942767159258168 NA NA NA hsa-miR-452-3p PRKCB 1.09618110917892 2.21867884261816e-07 -0.00995382054367333 0.966062170170983 mirMAP -0.288633705564416 7.41556259016727e-10 NA NA NA hsa-miR-589-3p PRKCB 1.59559692667315 6.2886410639161e-15 -0.00995382054367333 0.966062170170983 mirMAP -0.224077186704912 7.93186780188175e-06 NA NA NA hsa-miR-590-5p PRKCB 0.763025362395968 3.65305892505623e-09 -0.00995382054367333 0.966062170170983 miRanda -0.36636674657937 2.16525521339557e-06 NA NA NA hsa-miR-944 PRKCB 1.47323925060177 2.61626403984929e-13 -0.00995382054367333 0.966062170170983 mirMAP -0.228083074030307 3.27391957426865e-06 NA NA NA hsa-miR-100-5p PTGS2 -1.85857794619369 1.248973638996e-25 0.794164504521436 0.0150168127327614 miRNAWalker2_validate -0.257629633254623 0.000733130225395264 NA NA NA hsa-miR-101-3p PTGS2 -1.91263766544878 1.50270129259053e-39 0.794164504521436 0.0150168127327614 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.296006527448097 0.00110639256839217 26530100;21430074;24759835;26556718;24289600;23644120;24958470;26617722;19133256;24528073;25109742;23013439 Luciferase assay revealed that COX-2 was a direct target for miR-101-3p and overexpression of miR-101-3p decreased cellular COX-2 protein expression; Finally downregulation of miR-101-3p expression and upregulation of COX-2 was found in ESCC specimens from patients with smoking history; Taken together our findings revealed a new post-transcriptional mechanism by which CSE regulated COX-2 expression to favor cancer cell proliferation suggesting miR-101-3p as a potential biomarker and therapeutic target for smoke-related ESCC;Enforced expression of miR 101 inhibits prostate cancer cell growth by modulating the COX 2 pathway in vivo; In this study we investigated the mechanism of microRNA-101 miR-101-regulated COX-2 expression and the therapeutic potential of exogenous miR-101 for COX-2-associated cancer; We found that miR-101 inhibited COX-2 posttranscriptional expression by directly binding to the 3'-untranslated region 3'-UTR of COX-2 mRNA; In conclusion COX-2 is a direct target in miR-101 regulation of posttranscription; These data suggest that exogenous miR-101 may provide a new cancer therapy by directly inhibiting COX-2 expression;MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels;Cyclooxygenase 2 a Potential Therapeutic Target Is Regulated by miR 101 in Esophageal Squamous Cell Carcinoma; This study investigated the effect of miR-101 on ESCC through modulating COX-2 expression in ESCC; The luciferase reporter assay was used to verify COX-2 as a direct target of miR-101; Furthermore COX-2 was shown to be a target of miR-101;The expression of COX-2 in Hela cell was also examined by immunohistochemical staining and the correlation with miR-101 expression was analysed; Thus reduced miR-101 expression could participate in the development of cervical cancer at least partly through loss of inhibition of target gene COX-2 which probably occurs in a relative late phase of carcinogenesis;Expressions of COX 2 PKC α and miR 101 in gastric cancer and their correlations; To investigate the expressions of miR-101 protein kinase C-α PKC-α and cyclooxygenase-2 COX-2 in gastric cancer GC tissue and their correlations; RT-qPCR was used to examine miR-101 expression and Western blotting employed to detect PKC-α and COX-2 expressions in 57 cases of gastric cancer tissues and paired normal gastric mucosal tissues; The gastric cancer tissues showed a significantly lower miR-101 expression Z=6.102 P<0.05 but significantly higher expressions of COX-2 Z=14.436 P<0.05 and PKC-α Z=6.955 P<0.05 than the normal gastric tissues; PKC-α expression was positively correlated r=0.531 P<0.05 and miR-101 expression negatively correlated r=-0.627 P<0.05 with COX-2 expression in gastric cancer tissues; miR-101 PKC-α and COX-2 all play a role in the tumorigenesis and progression of gastric cancer; miR-101 and PKC-α might be new potential therapeutic targets for inhibiting COX-2 in gastric cancer;Interestingly cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1β-mediated repression of miR-101 and IL-1β-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration;Immunohistochemistry was performed to assess protein expression of the miR-101 target gene COX-2; Overexpression of miR-101 decreased expression of its target gene Cox-2 and inhibited proliferation and invasion and promoted apoptosis to suppress tumorigenicity;MiR 101 downregulation is involved in cyclooxygenase 2 overexpression in human colon cancer cells; In this paper we report the inverse correlation between COX-2 and miR-101 expression in colon cancer cell lines and we demonstrated in vitro the direct inhibition of COX-2 mRNA translation mediated by miR-101; These findings provide a novel molecular insight in the modulation of COX-2 at post-transcriptional level by miR-101 and strengthen the observation that miRNAs are highly implicated in the control of gene expression; An impairment of miR-101 levels could represent one of the leading causes of COX-2 overexpression in colon cancer cells;Roles of MiR 101 and its target gene Cox 2 in early diagnosis of cervical cancer in Uygur women; Use of down-regulation of miR-101 and up-regulation of Cox-2 as markers may play a role in early diagnosis of cervical cancer in Uygur women;Enforced expression of miR 101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase 2 pathway;Downregulation of miR 101 in gastric cancer correlates with cyclooxygenase 2 overexpression and tumor growth; Here we characterize miR-101 expression and its role in the regulation of COX-2 expression which in turn will provide us with additional insights into the potential therapeutic benefits of exogenous miR-101 for treatment of gastric cancer; We also found an inverse correlation between miR-101 and COX-2 expression in both gastric cancer specimens and cell lines; One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3'-UTR of COX-2 mRNA; These results collectively indicate that miR-101 may function as a tumor suppressor in gastric cancer with COX-2 as a direct target ;;;;tumorigenesis;progression;tumorigenesis;;;;;; esophageal cancer;prostate cancer;liver cancer;esophageal cancer;cervical and endocervical cancer;gastric cancer;lung cancer;cervical and endocervical cancer;colon cancer;cervical and endocervical cancer;bladder cancer;gastric cancer hsa-miR-195-3p PTGS2 -0.624259620429699 0.000164279659144497 0.794164504521436 0.0150168127327614 mirMAP -0.31747450705699 0.000220247203055445 NA NA NA hsa-miR-28-5p PTGS2 -0.026996999089909 0.733047113251652 0.794164504521436 0.0150168127327614 MirTarget;miRanda -0.485236689935353 0.00823431479507795 NA NA NA hsa-miR-381-3p PTGS2 -2.21357103508055 2.33039447871705e-24 0.794164504521436 0.0150168127327614 MirTarget -0.170488011652686 0.0064151422010179 NA NA NA hsa-miR-139-5p PTK2 -1.46099200329485 7.85040381494472e-22 0.712163037401015 4.63758818746064e-16 miRanda -0.157882233338886 9.67756748839253e-11 NA NA NA hsa-miR-140-5p PTK2 -0.412389003031485 0.000136051708543369 0.712163037401015 4.63758818746064e-16 miRanda -0.224034101429153 4.18323894722827e-10 NA NA NA hsa-miR-199b-5p PTK2 -1.08432682485992 7.68241801134089e-10 0.712163037401015 4.63758818746064e-16 miRanda -0.136803705433426 2.34749523384687e-10 NA NA NA hsa-miR-199b-5p PXN -1.08432682485992 7.68241801134089e-10 0.986636724558757 5.72433626659337e-13 MirTarget;PITA;miRNATAP -0.105651642435765 0.0019124082220145 NA NA NA hsa-miR-218-5p PXN -1.0725338636959 3.61493686604269e-09 0.986636724558757 5.72433626659337e-13 miRNATAP -0.180998581754835 3.19084651676556e-08 21159652 On this basis we hypothesized that PXN overexpression via miR-218 suppression may promote tumor progression and metastasis and that PXN may predict survival and relapse in non-small cell lung cancer NSCLC; Expression of miR-218 and PXN in 124 surgically resected lung tumors were evaluated by real-time PCR and immunohistochemical analysis; The prognostic value of miR-218 and PXN expression on overall survival OS and relapse-free survival RFS was analyzed by the Kaplan-Meier test and Cox regression analysis; miR-218 expression in lung tumors was negatively associated with PXN expression; Multivariate analyses showed that PXN and miR-218 might independently predict OS and RFS respectively in NSCLC; In a cell model PXN was negatively regulated by miR-218 and cell proliferation invasion and soft agar colony formation were enhanced by PXN overexpression induced by miR-218 suppression; Taken together our findings suggest that PXN overexpression induced by miR-218 suppression is an independent predictor of survival and relapse in NSCLC highlighting PXN as a potential therapeutic target to improve clinical outcomes in this disease metastasis;progression;poor survival lung squamous cell cancer hsa-miR-335-5p PXN -1.17227779671552 1.49282618530733e-10 0.986636724558757 5.72433626659337e-13 miRNAWalker2_validate -0.146996229064335 6.36943406611604e-06 NA NA NA hsa-miR-342-5p PXN 0.862385578881784 1.60007936373305e-08 0.986636724558757 5.72433626659337e-13 PITA;miRNATAP -0.106068665092979 0.00728756581580365 NA NA NA hsa-miR-382-5p RAC1 -0.512675955239656 0.00311534081639733 0.060247613846359 0.436073210860324 MirTarget -0.110732405915093 6.53593148835981e-09 NA NA NA hsa-miR-375 RAC2 -4.24070205340868 7.48368361454041e-28 1.54722243723033 1.85515860629167e-17 miRanda -0.164694891845942 1.8370066353598e-17 NA NA NA hsa-miR-195-5p SH2D2A -1.8367376818177 6.9944883988895e-31 2.22157355470086 1.18774728800985e-35 MirTarget -0.307205293946183 2.79204390021629e-10 NA NA NA hsa-miR-495-3p SH2D2A -1.47803501311999 6.88839745293927e-13 2.22157355470086 1.18774728800985e-35 MirTarget -0.128048719438166 0.00124124287324388 NA NA NA hsa-miR-497-5p SH2D2A -0.966244470847844 5.26505649147857e-12 2.22157355470086 1.18774728800985e-35 MirTarget -0.353707955648723 8.45290271698334e-10 NA NA NA hsa-miR-330-3p SPHK1 -0.0524949332825773 0.719856123539461 1.22956706692832 2.54632001529639e-15 miRNATAP -0.196129471681193 3.79811747044357e-05 NA NA NA hsa-miR-101-3p VEGFA -1.91263766544878 1.50270129259053e-39 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate -0.281477062331858 8.81075776241686e-11 NA NA NA hsa-miR-134-5p VEGFA -0.598302069876985 0.00124773585997939 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.114375387301794 0.00210306889630562 NA NA NA hsa-miR-140-5p VEGFA -0.412389003031485 0.000136051708543369 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.268410061738275 2.63838447575462e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.243749814009231 0.331546276920338 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.1837154779422 1.13782348414927e-11 NA NA NA hsa-miR-195-5p VEGFA -1.8367376818177 6.9944883988895e-31 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.266371206927854 4.016968187035e-11 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199b-5p VEGFA -1.08432682485992 7.68241801134089e-10 0.873514320132464 2.52351953389146e-08 miRanda -0.107087744674295 0.00559641745284255 NA NA NA hsa-miR-29a-3p VEGFA -1.26881270980079 2.82496991513463e-22 0.873514320132464 2.52351953389146e-08 MirTarget -0.288406509783812 9.95429090012523e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29c-3p VEGFA -2.08166260448948 8.3238369390898e-24 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;MirTarget -0.194088476141854 6.98364039221839e-10 NA NA NA hsa-miR-374a-5p VEGFA -0.621903385111545 6.61791773205282e-12 0.873514320132464 2.52351953389146e-08 MirTarget -0.350545644085801 3.16629895028707e-06 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-378a-3p VEGFA -1.50453783521372 9.41694954361173e-17 0.873514320132464 2.52351953389146e-08 miRNAWalker2_validate;miRTarBase -0.103722847977571 0.00515698881281656 NA NA NA