miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p FBN1 0.283468597868531 0.127007787220086 0.691519482636648 0.00278726958162726 mirMAP -0.392983378189799 2.0824947487849e-07 NA NA NA hsa-let-7b-3p FBN1 0.377956364821509 0.0061730103051373 0.691519482636648 0.00278726958162726 mirMAP -0.208517126115312 0.0464853348256187 NA NA NA hsa-let-7f-1-3p FBN1 1.09636075438131 3.42037366931931e-10 0.691519482636648 0.00278726958162726 mirMAP -0.279227503860216 0.000404946451822236 NA NA NA hsa-miR-16-2-3p FBN1 0.869267463341732 0.000785361809327569 0.691519482636648 0.00278726958162726 mirMAP -0.329252656194889 4.95614909682375e-10 NA NA NA hsa-miR-182-5p FBN1 1.73826081735237 5.69817940588551e-09 0.691519482636648 0.00278726958162726 miRNATAP -0.293507728978807 5.20616722609102e-11 NA NA NA hsa-miR-188-5p FBN1 1.57437249320621 2.78824007819973e-08 0.691519482636648 0.00278726958162726 PITA -0.221040510098652 1.39529544990002e-05 NA NA NA hsa-miR-192-5p FBN1 2.0867723747501 3.57854249239079e-08 0.691519482636648 0.00278726958162726 miRNAWalker2_validate -0.179668638948456 5.50319382495199e-07 NA NA NA hsa-miR-19b-1-5p FBN1 1.78323584062047 7.55784857614623e-15 0.691519482636648 0.00278726958162726 mirMAP -0.307684795488566 9.89982647680473e-08 NA NA NA hsa-miR-25-3p FBN1 0.948739680210032 3.62304579611938e-09 0.691519482636648 0.00278726958162726 mirMAP -0.412896612641392 1.35417900999554e-06 NA NA NA hsa-miR-29b-3p FBN1 0.0225365195743876 0.914313337784307 0.691519482636648 0.00278726958162726 miRNATAP -0.416732802618573 3.2811060877723e-10 NA NA NA hsa-miR-29c-3p FBN1 -1.34143813218298 2.77493790306384e-12 0.691519482636648 0.00278726958162726 miRNAWalker2_validate;miRTarBase -0.24675717752169 0.000515299328534621 NA NA NA hsa-miR-362-3p FBN1 0.994614346444282 4.39793878186399e-05 0.691519482636648 0.00278726958162726 miRanda;miRNATAP -0.392153135983374 9.51611285732974e-12 NA NA NA hsa-miR-375 FBN1 -0.348733074320394 0.47719066431766 0.691519482636648 0.00278726958162726 mirMAP -0.128898283436313 6.38541067075545e-06 NA NA NA hsa-miR-421 FBN1 1.26653675546617 2.35180826009926e-08 0.691519482636648 0.00278726958162726 mirMAP -0.208304120506215 0.000719756538692313 NA NA NA hsa-miR-429 FBN1 1.58250682050303 4.75828087352234e-05 0.691519482636648 0.00278726958162726 miRNATAP -0.265015593190118 2.77923762181938e-14 NA NA NA hsa-miR-486-5p FBN1 -1.52128065772506 4.50915908626354e-09 0.691519482636648 0.00278726958162726 PITA;miRanda;miRNATAP -0.195024147867139 0.000228926948287708 27133060 miR 486 5p inhibits cell growth of papillary thyroid carcinoma by targeting fibrillin 1; Fibrillin-1 FBN1 was shown to be a direct target of miR-486-5p and inversely regulated by miR-486-5p; FBN1 silencing led to decreased PTC cell proliferation and enhanced apoptosis in vitro similar to that mediated by miR-486-5p; Furthermore miR-486-5p over-expression or FBN1 knock-down inhibited while up-regulation of FBN1 boosted xenograft tumor formation in vivo; Our data suggest that miR-486-5p induces PTC cell growth inhibition and apoptosis by targeting and suppressing FBN1 thyroid cancer hsa-miR-576-5p FBN1 0.872721964495849 5.20470410008775e-05 0.691519482636648 0.00278726958162726 mirMAP -0.340498447091799 1.05075763678801e-07 NA NA NA hsa-miR-577 FBN1 0.615893340074725 0.210494450869356 0.691519482636648 0.00278726958162726 mirMAP -0.146033083901022 2.56112422662795e-06 NA NA NA hsa-miR-582-5p FBN1 0.0720675907490005 0.728284850619144 0.691519482636648 0.00278726958162726 miRNATAP -0.180086408419392 0.00909708881493333 NA NA NA hsa-miR-590-3p FBN1 0.858742926831233 0.000127281269371976 0.691519482636648 0.00278726958162726 miRanda;mirMAP -0.390136203476292 1.70135886230856e-10 NA NA NA hsa-miR-92a-3p FBN1 1.06124545165614 6.51550014372282e-08 0.691519482636648 0.00278726958162726 mirMAP -0.405471872852743 4.72250397120375e-09 NA NA NA