miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-182-5p AASS 3.53923166221814 5.07781258121574e-21 -1.35265775661789 5.38870424542386e-05 MirTarget -0.116410968280722 0.00482856243261934 NA NA NA hsa-miR-182-5p AATK 3.53923166221814 5.07781258121574e-21 -0.615969232464073 0.0257068187953113 MirTarget -0.114541191271719 0.000687000071712762 NA NA NA hsa-miR-182-5p ABL2 3.53923166221814 5.07781258121574e-21 -0.318835189302919 0.0455399452105181 mirMAP -0.142041939712293 6.07073497417664e-14 NA NA NA hsa-miR-182-5p ACVR1 3.53923166221814 5.07781258121574e-21 -0.440784615093559 0.011428168867015 MirTarget;miRNATAP -0.149490341775743 6.26318281352499e-13 NA NA NA hsa-miR-182-5p ACVRL1 3.53923166221814 5.07781258121574e-21 -1.24662368776506 2.70751841056871e-07 mirMAP -0.250597831078952 4.17846065343439e-18 NA NA NA hsa-miR-182-5p ADAM19 3.53923166221814 5.07781258121574e-21 -1.06497039316686 0.0189522972551201 miRNATAP -0.533109279002736 4.3570524845528e-24 NA NA NA hsa-miR-182-5p ADAMTS18 3.53923166221814 5.07781258121574e-21 -0.739139156012831 0.145989347823725 miRNATAP -0.216589313631971 0.000481201358820777 NA NA NA hsa-miR-182-5p ADAMTS4 3.53923166221814 5.07781258121574e-21 -2.17338507924301 2.13905891927026e-07 MirTarget -0.424153920938501 2.56296159859027e-17 NA NA NA hsa-miR-182-5p ADCY2 3.53923166221814 5.07781258121574e-21 -3.86571368883929 3.85227988382588e-11 miRNATAP -0.4013870076515 2.8800606809304e-08 NA NA NA hsa-miR-182-5p AFAP1 3.53923166221814 5.07781258121574e-21 -0.984844531728039 0.000121375966999112 mirMAP -0.263227885884499 4.06409424872021e-18 NA NA NA hsa-miR-182-5p AFF2 3.53923166221814 5.07781258121574e-21 -1.7276819820086 0.00201353678950772 mirMAP -0.216440007981155 0.00162093713424406 NA NA NA hsa-miR-182-5p AK5 3.53923166221814 5.07781258121574e-21 -1.17560423676368 0.0324844289646241 MirTarget -0.156469111076832 0.0203724925039315 NA NA NA hsa-miR-182-5p AKAP7 3.53923166221814 5.07781258121574e-21 -1.25860380700641 1.06625080623197e-05 miRNATAP -0.140799993045048 6.12760194588608e-05 NA NA NA hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-182-5p AMOTL2 3.53923166221814 5.07781258121574e-21 -1.01147657574476 0.000152881926388237 miRNATAP -0.239319000600015 7.17874355436452e-14 NA NA NA hsa-miR-182-5p ANK2 3.53923166221814 5.07781258121574e-21 -4.31721795702785 2.30783903904989e-14 miRNATAP -0.752812509507421 1.6975064517713e-29 NA NA NA hsa-miR-182-5p ANTXR2 3.53923166221814 5.07781258121574e-21 -2.30617470732809 4.54834840057871e-13 miRNATAP -0.451604586914995 2.85870546732696e-34 NA NA NA hsa-miR-182-5p ARHGAP6 3.53923166221814 5.07781258121574e-21 -3.24747805818142 5.3316262029649e-12 MirTarget -0.211814524046265 0.000329386374988928 NA NA NA hsa-miR-182-5p ARHGEF3 3.53923166221814 5.07781258121574e-21 -0.764795563081465 2.81227805578292e-06 MirTarget -0.112347246511755 1.55827549076219e-08 NA NA NA hsa-miR-182-5p ARHGEF4 3.53923166221814 5.07781258121574e-21 -1.4406738881977 0.0130992114003101 mirMAP -0.351544032749552 6.16715691444689e-07 NA NA NA hsa-miR-182-5p ARL4C 3.53923166221814 5.07781258121574e-21 -0.28406295826987 0.335346460301793 miRNATAP -0.190653550412615 8.42712858327153e-08 NA NA NA hsa-miR-182-5p ASAP1 3.53923166221814 5.07781258121574e-21 0.0593314983478699 0.779444757742406 mirMAP -0.108503236524537 2.41415341089199e-05 NA NA NA hsa-miR-182-5p ASB1 3.53923166221814 5.07781258121574e-21 -0.87000981136547 1.63208206880833e-08 mirMAP -0.157277050128226 1.27751629612482e-17 NA NA NA hsa-miR-182-5p ASXL3 3.53923166221814 5.07781258121574e-21 -3.33764959592997 4.422152746114e-10 mirMAP -0.36891952885931 2.24283710572372e-08 NA NA NA hsa-miR-181a-5p ATM 2.29556023480783 1.8138457900616e-21 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.126923788457429 2.84207726303723e-05 24531888;27150990;21102523;26113450;23656790 Ataxia-telangiectasia mutation ATM was predicted as a target gene of miR-181a with bioinformatics analysis and was verified by lucifersae reporter assay; A luciferase reporter assay demonstrated that ATM was a direct target of miR-181a miR-181a mimics transfection down regulated ATM mRNA and protein expression; There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues; Our study demonstrates that over-expression of miR-181a might be involved in development of gastric cancer by promoting proliferation and inhibiting apoptosis probably through directly targeting ATM miR-181a modulation may be a potential strategy for the development of miRNA-based therapy of gastric cancer;MiR 181a Promotes Proliferation of Human Acute Myeloid Leukemia Cells by Targeting ATM; Dual luciferase reporter gene assay showed that miR-181a significantly suppressed the reporter gene activity containing ATM 3'-UTR by about 56.8% P < 0.05 but it didn't suppress the reporter gene activity containing 3'-UTR ATM mutation; Western blot showed that miR-181a significantly downregulated the expression of ATM in human leukemia cells; It is also found that miR-181a was significantly increased in AML which showed a negative correlation with ATM expression; miR-181a promotes cell proliferation in AML by regulating the tumor suppressor ATM thus it plays the role as oncogene in pathogenesis of AML;Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;miR 181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM; Pediatric AML patients and healthy controls were enrolled and the expression of miR-181a and ataxia telangiectasia mutated ATM in tissues were examined using quantitative PCR; Moreover cell proliferation and cell cycle were evaluated in several cell lines HL60 NB4 and K562 by using flow cytometry after transfected with miR-181a mimics and inhibitors or ATM siRNA and control siRNA; Finally ATM as the potential target protein of miR-181a was examined; We found that miR-181a was significantly increased in pediatric AML which showed an inverse association with ATM expression; Luciferase activity of the reporter construct identified ATM as the direct molecular target of miR-181a; The results revealed novel mechanism through which miR-181a regulates G1/S transition and cell proliferation in pediatric AML by regulating the tumor suppressor ATM providing insights into the molecular mechanism in pediatric AML;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels ;;;; gastric cancer;acute myeloid leukemia;breast cancer;acute myeloid leukemia;breast cancer hsa-miR-181b-5p ATM 2.49307679431293 3.92829250217627e-20 -0.694304374354523 1.11905560067279e-05 MirTarget -0.106546210489637 8.13310251996423e-05 21102523;23656790 Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels ; breast cancer;breast cancer hsa-miR-186-5p ATM 1.47445398888668 3.0781726595413e-15 -0.694304374354523 1.11905560067279e-05 mirMAP -0.162572896698222 4.94897138455636e-05 NA NA NA hsa-miR-18a-5p ATM 3.78535678765353 3.72446596213886e-26 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.132647027735553 2.53006799595493e-10 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 2.49529833021187 1.57028265846699e-23 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.169669050219426 4.03808006538527e-09 NA NA NA hsa-miR-21-5p ATM 2.73773305747971 1.38864982139576e-43 -0.694304374354523 1.11905560067279e-05 mirMAP -0.176310423151013 4.47713388674926e-07 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-26a-2-3p ATM 0.823520019989974 0.00017092160823769 -0.694304374354523 1.11905560067279e-05 MirTarget -0.118965349103283 0.000759103078575479 NA NA NA hsa-miR-26b-5p ATM 0.885393662798425 3.2116297961629e-06 -0.694304374354523 1.11905560067279e-05 MirTarget -0.112936121726645 0.00532953311791061 NA NA NA hsa-miR-30c-5p ATM 0.778774633108 0.000285599212429136 -0.694304374354523 1.11905560067279e-05 mirMAP -0.107066600206639 0.00288450607513559 NA NA NA hsa-miR-324-5p ATM 2.95683728155095 1.32960514360912e-20 -0.694304374354523 1.11905560067279e-05 miRanda -0.111813212915851 1.04521240946738e-06 NA NA NA hsa-miR-362-3p ATM 2.0756816987665 3.89026064579331e-12 -0.694304374354523 1.11905560067279e-05 miRanda -0.112278812357676 1.35632724301173e-05 NA NA NA hsa-miR-455-5p ATM 2.2582442061694 1.43472128037398e-13 -0.694304374354523 1.11905560067279e-05 miRanda -0.106749319544671 1.15313735793322e-05 NA NA NA hsa-miR-576-5p ATM 2.20467023993664 3.4053475193793e-19 -0.694304374354523 1.11905560067279e-05 mirMAP -0.17622953753732 2.51071157737834e-09 NA NA NA hsa-miR-590-3p ATM 2.59289455139753 1.03200520972022e-21 -0.694304374354523 1.11905560067279e-05 miRanda;mirMAP -0.147925962529486 7.50176131513898e-08 NA NA NA hsa-miR-590-5p ATM 3.18300989862077 2.06813568597893e-26 -0.694304374354523 1.11905560067279e-05 mirMAP -0.155698076358082 1.697182104602e-10 NA NA NA hsa-miR-92a-3p ATM 2.06460102658973 1.44784291084757e-19 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.174566583478402 5.02119051710453e-08 NA NA NA hsa-miR-182-5p ATP10A 3.53923166221814 5.07781258121574e-21 -0.811415026703069 0.0374058146431988 mirMAP -0.404007688800077 1.22122911490614e-18 NA NA NA hsa-miR-182-5p ATP10D 3.53923166221814 5.07781258121574e-21 -0.688708018852498 0.010040565207979 MirTarget -0.222395619841383 3.7701551612448e-12 NA NA NA hsa-miR-182-5p ATP2B4 3.53923166221814 5.07781258121574e-21 -1.72037479984404 8.20260471374597e-10 mirMAP -0.289376118275112 7.95199686473916e-18 NA NA NA hsa-miR-182-5p ATP8A1 3.53923166221814 5.07781258121574e-21 -1.47752118217688 7.63290299845151e-05 MirTarget;miRNATAP -0.15882578962994 0.000545688793389147 NA NA NA hsa-miR-182-5p ATXN1 3.53923166221814 5.07781258121574e-21 -1.5104377454496 2.95939614593378e-08 mirMAP;miRNATAP -0.3101824982758 6.56589554898194e-22 NA NA NA hsa-miR-182-5p B3GNT7 3.53923166221814 5.07781258121574e-21 -0.341972826249343 0.376128089610537 mirMAP -0.134677612130579 0.00433938887203324 NA NA NA hsa-miR-182-5p BACE1 3.53923166221814 5.07781258121574e-21 -0.723461241968299 0.00095792938893533 mirMAP -0.225156215179252 3.067794590672e-18 NA NA NA hsa-miR-182-5p BACH2 3.53923166221814 5.07781258121574e-21 -1.52271748612635 0.00133867288726185 MirTarget;mirMAP;miRNATAP -0.441071360909214 6.40756845049909e-15 NA NA NA hsa-let-7a-5p BCL2 0.618599506841644 2.76973453058748e-05 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.227211670110314 0.0179425982768944 24643702;26915294 Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl 2 via microRNA let 7a and miR 34b in ovarian cancer cells; Moreover the relative abundance of Bcl-2 and microRNAs let-7a miR-34b expressions were detected by quantitative real-time PCR qRT-PCR and Western blotting; E2 + P4 promoted the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells; When the expression of let-7a or/and miR-34b was inhibited using miRNA inhibitors E2 + P4 treatment did not change the protein level of Bcl-2; E2 + P4 significantly inhibited the cell survival promoted the cell apoptosis induced the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively poor survival;poor survival ovarian cancer;lung cancer hsa-miR-103a-3p BCL2 1.44083190496858 1.53799939616416e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.316592082591341 5.34263132858783e-06 NA NA NA hsa-miR-125a-5p BCL2 0.599529391575274 0.0102300147180307 -2.02088083891464 5.5300725103229e-13 PITA -0.204181839304005 0.000647180620809067 NA NA NA hsa-miR-126-5p BCL2 0.895338176458417 2.33372756450713e-05 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136813897862068 0.0382651228386025 NA NA NA hsa-miR-130b-5p BCL2 2.9963110846538 1.98883029416455e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.257233532043175 6.21636254360678e-11 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-15a-5p BCL2 2.34669284378787 1.69544424500258e-23 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.391979588821952 1.08722628903108e-12 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 2.33847028227712 4.29662877950836e-19 -2.02088083891464 5.5300725103229e-13 mirMAP -0.323477257690888 1.09586549927814e-10 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-15b-5p BCL2 1.57112623124278 9.14247846750597e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.256427911729671 3.30685638311642e-05 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-16-1-3p BCL2 2.56983217111073 3.02262181237943e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.3266254366235 1.09255462667175e-11 18931683 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 prostate cancer hsa-miR-16-2-3p BCL2 2.31623086727196 4.29838149388188e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.283819463467791 5.74174499512362e-08 NA NA NA hsa-miR-16-5p BCL2 1.75824877145857 1.68592440033108e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.288487498854428 4.63144203616397e-06 21336967;24447552;18449891;25435430;24598659;18931683;22966344;25623762 P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;worse prognosis;drug resistance;;;;poor survival;drug resistance liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-17-5p BCL2 3.2710598467455 9.93128340539455e-27 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.293095808916295 2.47054725414332e-12 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181a-5p BCL2 2.29556023480783 1.8138457900616e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.302999442697681 2.70012636306699e-08 24267199;23740615;25524579;27534652;24335172 Bufalin was found to induce the expression of miR-181a a small non-coding RNA believed to induce apoptosis by repressing its target gene BCL-2; In prostate cancer PC-3cell line bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation;The results from Western blotting indicated that miR-181a might be associated with the up-regulation of bcl-2 and matrix metalloproteinase 9 and the down-regulation of tissue inhibitor of metalloproteinases-3 and p21 in MG63 cells;Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression;In addition inhibition of miR-181a promoted apoptosis of HeLa and CaSKi cells due to increasing Bax expression and decreasing Bcl-2 expression;The function role of miR 181a in chemosensitivity to adriamycin by targeting Bcl 2 in low invasive breast cancer cells; Luciferase reporter vector with the putative BCL-2 3' untranslated region 3'UTR was constructed to explore whether BCL-2 was a direct target gene of miR-181a; Real-time PCR was performed to test the expression of miR-181a and Bcl-2 in the selected breast cancer tissue samples; Transfected with miR-181a mimic in cells resulted in the decreased expression of Bcl-2; At least in part the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of miR-181a enhanced adriamycin-induced apoptosis via targeting Bcl-2 ;;;; prostate cancer;sarcoma;lung squamous cell cancer;cervical and endocervical cancer;breast cancer hsa-miR-181b-5p BCL2 2.49307679431293 3.92829250217627e-20 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.305267910529038 2.57343031129337e-10 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-181c-5p BCL2 1.58587920618301 1.57506918816933e-10 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.112460550118007 0.0424640002427638 NA NA NA hsa-miR-181d-5p BCL2 1.52204912185579 9.2693319057748e-08 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.138340152158444 0.00425126630916248 NA NA NA hsa-miR-182-5p BCL2 3.53923166221814 5.07781258121574e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.179869914139863 2.52267854475577e-07 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-186-5p BCL2 1.47445398888668 3.0781726595413e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.423453081728092 3.67590705887486e-09 NA NA NA hsa-miR-192-5p BCL2 2.69002528723195 1.22990188194432e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.208867066110207 3.33628652880772e-07 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-200a-5p BCL2 3.86316681673704 1.81076942093171e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.15999187261028 4.28833785580744e-09 NA NA NA hsa-miR-200b-3p BCL2 3.78235093249346 3.18343003239465e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.147905318391455 3.02424877197984e-08 NA NA NA hsa-miR-200b-5p BCL2 2.54484902707822 1.59240467582976e-06 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136099351840362 2.8230250510626e-06 NA NA NA hsa-miR-200c-3p BCL2 3.50132673580082 2.42716349086937e-15 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.190113918290914 1.87463163361428e-10 NA NA NA hsa-miR-20a-3p BCL2 2.92621109947706 2.49504904635375e-17 -2.02088083891464 5.5300725103229e-13 mirMAP -0.210564396671593 8.96802878439544e-08 NA NA NA hsa-miR-20a-5p BCL2 3.15577933619191 4.19753346442454e-25 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.265706884379661 3.5423039457333e-10 NA NA NA hsa-miR-21-5p BCL2 2.73773305747971 1.38864982139576e-43 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.366618885310627 5.78881699391161e-09 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-224-5p BCL2 2.94107125335675 5.72194099515157e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.119749067233376 1.76067406110872e-06 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 2.07171035460647 3.15853539996136e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.329656547931865 2.75296639271459e-10 NA NA NA hsa-miR-29a-5p BCL2 1.46749674755271 3.34605004270294e-07 -2.02088083891464 5.5300725103229e-13 mirMAP -0.213517369621975 2.31345511002058e-05 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 1.65828197923813 1.02676780888141e-09 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.296891319533915 2.28427123681482e-09 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 2.74629919868982 1.86846589298284e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.154823847891893 5.79242637365127e-06 NA NA NA hsa-miR-32-3p BCL2 2.02436999565685 5.94091197945307e-09 -2.02088083891464 5.5300725103229e-13 mirMAP -0.20244441600453 5.71853892832186e-06 NA NA NA hsa-miR-335-3p BCL2 3.08791651139852 5.31309869723517e-12 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104382164677445 0.000555265264147089 NA NA NA hsa-miR-33a-5p BCL2 3.79671563098419 1.15966309820345e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.197338268783918 2.87180137117656e-09 NA NA NA hsa-miR-34a-5p BCL2 1.9016323452565 1.43092834643601e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.313298897109154 6.78995714898249e-09 24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582;23862748 In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;;; breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-365a-3p BCL2 -0.0388985816963467 0.859114494267351 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.26287248585935 3.91090481330584e-05 NA NA NA hsa-miR-429 BCL2 4.48815175680773 2.44117492218206e-17 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.154017674076185 5.15216313360141e-10 23999873;26513239;26511969 MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; esophageal cancer;gastric cancer;glioblastoma hsa-miR-450b-5p BCL2 1.69244418548325 1.68064054148881e-10 -2.02088083891464 5.5300725103229e-13 mirMAP -0.195491457721654 0.000146490668566645 NA NA NA hsa-miR-452-5p BCL2 1.37180058737183 0.00171494843537772 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104092924779063 0.00100591652628657 NA NA NA hsa-miR-455-5p BCL2 2.2582442061694 1.43472128037398e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.296135324171891 8.75003372187937e-12 NA NA NA hsa-miR-582-5p BCL2 0.609226359812689 0.032988717891497 -2.02088083891464 5.5300725103229e-13 PITA -0.211866972823695 1.29345936711211e-05 NA NA NA hsa-miR-590-3p BCL2 2.59289455139753 1.03200520972022e-21 -2.02088083891464 5.5300725103229e-13 miRanda;mirMAP -0.268687896594515 6.89769791912093e-08 NA NA NA hsa-miR-590-5p BCL2 3.18300989862077 2.06813568597893e-26 -2.02088083891464 5.5300725103229e-13 miRanda -0.311666149337473 1.27642835632825e-12 NA NA NA hsa-miR-629-5p BCL2 2.10182419359635 1.51788571125757e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.237720791875816 2.9555469743804e-06 NA NA NA hsa-miR-664a-5p BCL2 0.505019913598436 0.032933350691651 -2.02088083891464 5.5300725103229e-13 mirMAP -0.133435367665978 0.0249936816629116 NA NA NA hsa-miR-7-1-3p BCL2 1.84950311431067 1.25300363397654e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.256930851687325 1.96074632615661e-06 NA NA NA hsa-miR-7-5p BCL2 2.28980165299999 1.5131097560452e-07 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.178441327891617 1.03482718248784e-07 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-96-5p BCL2 4.89433085814374 1.92000659886961e-31 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;TargetScan -0.202123113149013 6.78873155803595e-11 NA NA NA hsa-miR-182-5p BDNF 3.53923166221814 5.07781258121574e-21 -2.90846311399482 3.32327619207597e-11 MirTarget;miRNATAP -0.304142174368882 2.036484274037e-08 NA NA NA hsa-miR-182-5p BHLHE22 3.53923166221814 5.07781258121574e-21 -1.78085310196095 8.27640345654744e-06 MirTarget;miRNATAP -0.125404173945967 0.0111628165771551 NA NA NA hsa-miR-34a-5p BIRC3 1.9016323452565 1.43092834643601e-14 -1.14878434773067 0.00715931622274468 miRNAWalker2_validate -0.217054924716933 0.00780122048146313 NA NA NA hsa-miR-651-5p BIRC3 2.32951837918862 1.62508965949028e-11 -1.14878434773067 0.00715931622274468 MirTarget -0.407201062114202 3.04074465541569e-10 NA NA NA hsa-miR-664a-3p BIRC3 0.634721925861133 0.00520070178640421 -1.14878434773067 0.00715931622274468 mirMAP -0.30056739615358 0.00101453991329218 NA NA NA hsa-miR-98-5p BIRC3 1.11154309866014 1.24143909012085e-08 -1.14878434773067 0.00715931622274468 miRNAWalker2_validate -0.732739588263987 1.05214961960018e-12 NA NA NA hsa-miR-182-5p BMPER 3.53923166221814 5.07781258121574e-21 -2.37696330630979 7.93036685759152e-08 MirTarget -0.310176404863268 1.06003843170975e-08 NA NA NA hsa-miR-182-5p BMPR1B 3.53923166221814 5.07781258121574e-21 0.0707965297684667 0.914043396353822 MirTarget -0.352429426701482 9.54099393700212e-06 NA NA NA hsa-miR-182-5p BNC2 3.53923166221814 5.07781258121574e-21 -2.95176911794991 3.46014802400024e-09 MirTarget;miRNATAP -0.71776251013895 3.86413735645154e-36 NA NA NA hsa-miR-182-5p BRMS1L 3.53923166221814 5.07781258121574e-21 -0.506070486086406 0.00391457381381874 MirTarget -0.116105153227067 4.38175464384311e-08 NA NA NA hsa-miR-182-5p BTLA 3.53923166221814 5.07781258121574e-21 -1.3093113714544 0.0055885120684256 MirTarget -0.383022346212665 1.4561081231856e-11 NA NA NA hsa-miR-182-5p C15orf52 3.53923166221814 5.07781258121574e-21 -1.1812614690092 0.00259990683553622 mirMAP -0.155715424203129 0.00120712780212423 NA NA NA hsa-miR-182-5p C17orf51 3.53923166221814 5.07781258121574e-21 -0.678914258700408 0.0225411911064938 mirMAP -0.229058546440458 1.48398857874875e-10 NA NA NA hsa-miR-182-5p C1orf21 3.53923166221814 5.07781258121574e-21 -1.50529673423141 7.359521051655e-11 mirMAP -0.136807831463124 1.81284237973681e-06 NA NA NA hsa-miR-182-5p CACNA2D1 3.53923166221814 5.07781258121574e-21 -3.31556565717047 8.68804644381516e-07 miRNATAP -0.802351589400528 3.37596704110403e-24 NA NA NA hsa-miR-182-5p CACNB2 3.53923166221814 5.07781258121574e-21 -2.97276927954599 1.73108973462894e-15 miRNATAP -0.365172476882356 1.60928198337665e-15 NA NA NA hsa-miR-182-5p CACNB4 3.53923166221814 5.07781258121574e-21 -2.87454559120761 1.1475342642129e-10 miRNATAP -0.316604534485063 8.60776206418429e-09 NA NA NA hsa-miR-182-5p CADM1 3.53923166221814 5.07781258121574e-21 -1.1928516537365 0.0125125326037739 miRNATAP -0.138741614978997 0.0180136306085462 24445397 TGF β upregulates miR 182 expression to promote gallbladder cancer metastasis by targeting CADM1; We further identified that the cell adhesion molecule1 CADM1 is a new target gene of miR-182 miR-182 negatively regulates CADM1 expression in vitro and in vivo metastasis bladder cancer hsa-miR-182-5p CADM2 3.53923166221814 5.07781258121574e-21 -3.83563052563186 2.24615008924082e-11 MirTarget;mirMAP;miRNATAP -0.257669129298721 0.000327158089637738 NA NA NA hsa-miR-182-5p CALD1 3.53923166221814 5.07781258121574e-21 -2.4663455628847 1.26294093745705e-11 MirTarget -0.572370021752522 4.34620815049957e-44 NA NA NA hsa-miR-101-3p CAPN2 0.522819989585461 0.00375627731618038 -0.422341253524924 0.0913287396375096 miRNAWalker2_validate;MirTarget -0.50384520654326 1.83370655936121e-14 NA NA NA hsa-miR-107 CAPN2 1.30977326593435 1.30372468603965e-11 -0.422341253524924 0.0913287396375096 miRanda -0.437052765176765 3.2546933497498e-13 NA NA NA hsa-miR-1468-5p CAPN2 0.0469536064343461 0.881810795145912 -0.422341253524924 0.0913287396375096 MirTarget -0.232939493923959 7.04451041151474e-10 NA NA NA hsa-miR-20a-3p CAPN2 2.92621109947706 2.49504904635375e-17 -0.422341253524924 0.0913287396375096 MirTarget -0.115847953441966 0.000784753626422282 NA NA NA hsa-miR-320a CAPN2 0.438165828017084 0.0390159073347133 -0.422341253524924 0.0913287396375096 miRanda -0.277145040818614 1.10455221350909e-06 NA NA NA hsa-miR-320b CAPN2 1.55692969039548 1.41071034251915e-08 -0.422341253524924 0.0913287396375096 miRanda -0.172007383267619 6.96931261650163e-05 NA NA NA hsa-miR-33a-3p CAPN2 1.72765312072219 1.51784443453521e-07 -0.422341253524924 0.0913287396375096 mirMAP -0.270141056401029 4.05112944673904e-12 NA NA NA hsa-miR-421 CAPN2 1.17791565395543 6.78526676976629e-06 -0.422341253524924 0.0913287396375096 miRanda -0.251126865613037 3.2279294019974e-08 NA NA NA hsa-miR-590-3p CAPN2 2.59289455139753 1.03200520972022e-21 -0.422341253524924 0.0913287396375096 miRanda -0.14408856443896 0.00096528080440921 NA NA NA hsa-miR-590-5p CAPN2 3.18300989862077 2.06813568597893e-26 -0.422341253524924 0.0913287396375096 miRanda -0.158328870843835 4.56868205430932e-05 NA NA NA hsa-miR-33a-3p CASP10 1.72765312072219 1.51784443453521e-07 0.0928615128292813 0.717578504954206 mirMAP -0.104979467957295 0.0102694577013009 NA NA NA hsa-miR-374a-3p CASP10 0.533309330504947 0.00192918429705142 0.0928615128292813 0.717578504954206 mirMAP -0.20364512927735 0.00522441741668315 NA NA NA hsa-miR-421 CASP10 1.17791565395543 6.78526676976629e-06 0.0928615128292813 0.717578504954206 mirMAP -0.157687882200134 0.000810622936052014 NA NA NA hsa-miR-744-3p CASP10 2.7517405670917 4.22040908411227e-14 0.0928615128292813 0.717578504954206 mirMAP -0.141817879498213 1.49202617610436e-05 NA NA NA hsa-miR-199a-3p CASP9 0.640600337515787 0.0380326905134914 -0.446359927280876 0.00400976702291555 mirMAP -0.146082132838509 1.00313136531724e-09 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 0.643923492750702 0.0371742251925406 -0.446359927280876 0.00400976702291555 mirMAP -0.146136089499986 9.60609442207656e-10 NA NA NA hsa-miR-222-5p CASP9 1.25632771414778 0.000138653440511922 -0.446359927280876 0.00400976702291555 mirMAP -0.126831808191525 1.31064720813193e-08 NA NA NA hsa-miR-182-5p CBFA2T3 3.53923166221814 5.07781258121574e-21 -1.55556335084053 2.30574321070702e-05 MirTarget;miRNATAP -0.101667349232731 0.0252687373220531 NA NA NA hsa-miR-182-5p CBX6 3.53923166221814 5.07781258121574e-21 -1.53953176885359 2.83932741324751e-07 miRNAWalker2_validate -0.187526276698243 3.46475443847444e-07 NA NA NA hsa-miR-182-5p CCDC88A 3.53923166221814 5.07781258121574e-21 -0.76463960543305 0.0119877409095406 miRNATAP -0.271831447720421 6.56284260787347e-14 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-182-5p CD209 3.53923166221814 5.07781258121574e-21 -1.78312650459774 0.000348543978778311 mirMAP -0.63946225835341 7.9320761453835e-29 NA NA NA hsa-miR-182-5p CD226 3.53923166221814 5.07781258121574e-21 -1.60922864485771 0.000254727297606939 MirTarget -0.426275694537129 3.93034272235752e-16 NA NA NA hsa-miR-182-5p CD274 3.53923166221814 5.07781258121574e-21 0.0610119269874347 0.90454084693838 mirMAP -0.315636435163749 2.85172426239732e-07 NA NA NA hsa-miR-182-5p CD47 3.53923166221814 5.07781258121574e-21 -0.164318188512451 0.480797231316326 MirTarget;miRNATAP -0.13449272547477 1.85234112980256e-06 NA NA NA hsa-miR-182-5p CD59 3.53923166221814 5.07781258121574e-21 -0.701153559236412 0.00130409241528683 MirTarget -0.144218246334533 4.83638010283245e-08 NA NA NA hsa-miR-182-5p CDC42BPA 3.53923166221814 5.07781258121574e-21 -1.41193338652648 2.19437213080473e-10 MirTarget;miRNATAP -0.185215897092821 9.30283725574719e-12 NA NA NA hsa-miR-182-5p CDC42EP3 3.53923166221814 5.07781258121574e-21 -1.35474123311743 4.46611463922157e-07 mirMAP -0.250823977657232 7.40811822217889e-15 NA NA NA hsa-miR-182-5p CDK6 3.53923166221814 5.07781258121574e-21 -0.774202349805119 0.064787030605636 mirMAP -0.342809938093979 8.28135113019132e-12 NA NA NA hsa-miR-182-5p CDKN1A 3.53923166221814 5.07781258121574e-21 -1.29236263370998 3.21238784768704e-06 miRNAWalker2_validate -0.109364926293111 0.00141758512280426 NA NA NA hsa-miR-182-5p CDKN2C 3.53923166221814 5.07781258121574e-21 0.22688212352847 0.433133415352322 MirTarget -0.132415467904401 0.00017052034340074 NA NA NA hsa-miR-182-5p CDV3 3.53923166221814 5.07781258121574e-21 -0.422762901340256 0.00210317952393349 MirTarget;miRNATAP -0.125154689954442 1.76580464983971e-14 NA NA NA hsa-miR-182-5p CECR1 3.53923166221814 5.07781258121574e-21 -0.680299587123653 0.0577716541397693 mirMAP -0.154858152293302 0.000402939138056666 NA NA NA hsa-miR-182-5p CELF2 3.53923166221814 5.07781258121574e-21 -3.04719737979328 4.72041352009215e-15 mirMAP;miRNATAP -0.543435870286861 9.24306112718155e-33 NA NA NA hsa-miR-107 CFLAR 1.30977326593435 1.30372468603965e-11 -0.231925856222684 0.202844044313639 miRanda -0.148357712217052 0.000900731169471226 NA NA NA hsa-miR-125a-5p CFLAR 0.599529391575274 0.0102300147180307 -0.231925856222684 0.202844044313639 miRanda -0.225494307449277 1.29185039963355e-09 NA NA NA hsa-miR-130b-3p CFLAR 3.5350292994509 1.73934183852569e-27 -0.231925856222684 0.202844044313639 mirMAP -0.145696928019461 4.93456456035999e-09 NA NA NA hsa-miR-15b-5p CFLAR 1.57112623124278 9.14247846750597e-13 -0.231925856222684 0.202844044313639 mirMAP -0.101026335268494 0.00988724932214317 NA NA NA hsa-miR-186-5p CFLAR 1.47445398888668 3.0781726595413e-15 -0.231925856222684 0.202844044313639 mirMAP -0.161290321910154 0.000432850514170424 NA NA NA hsa-miR-301a-3p CFLAR 2.81024345929638 2.29784847962242e-17 -0.231925856222684 0.202844044313639 mirMAP -0.168172963252665 2.02871497274292e-10 NA NA NA hsa-miR-30b-3p CFLAR 0.834142820354026 0.000972582820878813 -0.231925856222684 0.202844044313639 mirMAP -0.176108209676801 3.44450275553177e-07 NA NA NA hsa-miR-320a CFLAR 0.438165828017084 0.0390159073347133 -0.231925856222684 0.202844044313639 miRanda -0.187083028324921 6.26248969577351e-06 NA NA NA hsa-miR-421 CFLAR 1.17791565395543 6.78526676976629e-06 -0.231925856222684 0.202844044313639 miRanda -0.14658086248006 1.02286863777652e-05 NA NA NA hsa-miR-454-3p CFLAR 2.47234127820054 1.12878018736016e-21 -0.231925856222684 0.202844044313639 mirMAP -0.118171420962222 0.000376451937569571 NA NA NA hsa-miR-484 CFLAR 1.81844463411787 1.82951571230938e-15 -0.231925856222684 0.202844044313639 mirMAP -0.145571572520698 9.02314434337118e-05 NA NA NA hsa-miR-182-5p CHL1 3.53923166221814 5.07781258121574e-21 -2.42464081478466 0.000427906865227034 MirTarget;miRNATAP -0.305780373755428 0.000295276463094988 24971532 miR 182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma; Bioinformatics analysis revealed close homolog of LI CHL1 as a potential target of miR-182; Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines; miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3'-untranslated region 3'-UTR; Silencing of CHL1 counteracted the effects of miR-182 suppression while its overexpression mimicked these effects; Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1 supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC thyroid cancer hsa-miR-182-5p CHST10 3.53923166221814 5.07781258121574e-21 -0.673810565184832 0.061091789048812 miRNATAP -0.157440715530544 0.000336285052753459 NA NA NA hsa-miR-182-5p CHST11 3.53923166221814 5.07781258121574e-21 0.53998313547079 0.231103989518921 miRNATAP -0.366804749952682 1.01801990444519e-11 NA NA NA hsa-miR-29b-2-5p CHUK 0.910668640983475 0.00666655585493488 -0.123960303858583 0.302722046952969 MirTarget -0.105463511044412 4.36313837727314e-10 NA NA NA hsa-miR-497-5p CHUK 0.0257087130056286 0.918145413833358 -0.123960303858583 0.302722046952969 MirTarget -0.130303574602807 1.33264117705817e-08 NA NA NA hsa-miR-182-5p CLIC5 3.53923166221814 5.07781258121574e-21 -1.43632340622029 0.000563963531312954 miRNATAP -0.308329255813556 9.21561654884992e-10 NA NA NA hsa-miR-182-5p CLUAP1 3.53923166221814 5.07781258121574e-21 -0.818407818826761 2.60272053307672e-05 miRNATAP -0.118969545991895 5.38555541537669e-07 NA NA NA hsa-miR-182-5p CNN3 3.53923166221814 5.07781258121574e-21 -0.662842637540786 0.00534632089235666 MirTarget -0.156220005087751 5.86829555505636e-08 NA NA NA hsa-miR-182-5p CNTN1 3.53923166221814 5.07781258121574e-21 -4.98280431564283 1.02293078354206e-09 MirTarget;miRNATAP -0.868496511609559 6.7236399661984e-19 NA NA NA hsa-miR-182-5p COL4A4 3.53923166221814 5.07781258121574e-21 -2.67173783661591 1.38931523312633e-08 MirTarget -0.362520040793316 2.96679913995388e-10 NA NA NA hsa-miR-182-5p CORO1C 3.53923166221814 5.07781258121574e-21 -1.12142787999647 2.05016310243217e-07 MirTarget;miRNATAP -0.302054427538835 1.70433982710935e-34 NA NA NA hsa-miR-182-5p CPEB1 3.53923166221814 5.07781258121574e-21 -4.6814370281438 4.97746958394883e-18 miRNATAP -0.748121290214591 1.90908303930684e-31 NA NA NA hsa-miR-182-5p CREB3L1 3.53923166221814 5.07781258121574e-21 -1.81228769825907 2.53797773630782e-05 MirTarget -0.390694636450428 3.73594300120646e-14 NA NA NA hsa-miR-182-5p CREB5 3.53923166221814 5.07781258121574e-21 -2.27679484644664 4.56595042875634e-09 mirMAP -0.464348743181962 3.89829884732289e-24 NA NA NA hsa-miR-182-5p CRISPLD2 3.53923166221814 5.07781258121574e-21 -2.53383239481451 2.94527993191503e-12 mirMAP -0.420716933719727 3.17110637104215e-22 NA NA NA hsa-miR-125a-5p CSF2RB 0.599529391575274 0.0102300147180307 -0.739086291347396 0.0696045958228138 miRanda -0.426358007692611 3.75324813924671e-07 NA NA NA hsa-miR-15b-3p CSF2RB 2.33847028227712 4.29662877950836e-19 -0.739086291347396 0.0696045958228138 mirMAP -0.410621118990345 8.08744457322504e-09 NA NA NA hsa-miR-181b-5p CSF2RB 2.49307679431293 3.92829250217627e-20 -0.739086291347396 0.0696045958228138 MirTarget -0.199878586632952 0.0040462000934792 NA NA NA hsa-miR-181c-5p CSF2RB 1.58587920618301 1.57506918816933e-10 -0.739086291347396 0.0696045958228138 MirTarget -0.192897492889798 0.0137082096418576 NA NA NA hsa-miR-181d-5p CSF2RB 1.52204912185579 9.2693319057748e-08 -0.739086291347396 0.0696045958228138 MirTarget -0.305318018697499 6.94331838017145e-06 NA NA NA hsa-miR-186-5p CSF2RB 1.47445398888668 3.0781726595413e-15 -0.739086291347396 0.0696045958228138 mirMAP -0.36439054422735 0.000394153164171476 NA NA NA hsa-miR-19a-3p CSF2RB 3.42309334186656 3.02671914353412e-28 -0.739086291347396 0.0696045958228138 MirTarget -0.217107868095224 0.00024429476771933 NA NA NA hsa-miR-19b-3p CSF2RB 2.49529833021187 1.57028265846699e-23 -0.739086291347396 0.0696045958228138 MirTarget -0.339753464615837 5.03583434435228e-06 NA NA NA hsa-miR-30b-3p CSF2RB 0.834142820354026 0.000972582820878813 -0.739086291347396 0.0696045958228138 MirTarget -0.473179222241933 7.9171965820414e-10 NA NA NA hsa-miR-452-3p CSF2RB 2.42521958420768 4.08754552781156e-07 -0.739086291347396 0.0696045958228138 mirMAP -0.135652814910086 0.000851140820930795 NA NA NA hsa-miR-532-5p CSF2RB 1.55697650978597 1.57884735535196e-11 -0.739086291347396 0.0696045958228138 MirTarget -0.208350232426084 0.0129885839785501 NA NA NA hsa-miR-576-5p CSF2RB 2.20467023993664 3.4053475193793e-19 -0.739086291347396 0.0696045958228138 miRNATAP -0.289248506739264 0.000161113961006424 NA NA NA hsa-miR-182-5p CSMD2 3.53923166221814 5.07781258121574e-21 0.911378035710038 0.0161997994935285 mirMAP -0.221047758970605 1.58407801737189e-06 NA NA NA hsa-miR-182-5p CYLD 3.53923166221814 5.07781258121574e-21 -0.892927493541401 1.56901081849426e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.170088683970184 6.08932858594753e-17 27476169 We then demonstrated that knockdown of miR-182 up-regulated the expression of cylindromatosis CYLD deubiquitinase which promoted the formation of death-inducing signaling complex DISC and subsequent caspase-8 activation in TNF-α-treated BT-549 cells breast cancer hsa-miR-182-5p DAAM2 3.53923166221814 5.07781258121574e-21 -2.22700754971104 2.14986647076169e-10 mirMAP -0.375542841324343 4.32635099356557e-19 NA NA NA hsa-miR-182-5p DACT1 3.53923166221814 5.07781258121574e-21 -1.78085143314576 2.05886005067419e-05 MirTarget -0.429298253756581 5.43121387900343e-18 NA NA NA hsa-miR-182-5p DENND5B 3.53923166221814 5.07781258121574e-21 -1.35091655519941 9.63273930805463e-05 MirTarget;miRNATAP -0.327441318585945 2.38277083089333e-15 NA NA NA hsa-miR-365a-3p DFFB -0.0388985816963467 0.859114494267351 0.808547923724971 3.00427717245982e-08 MirTarget -0.112300683568728 0.000635832870706886 NA NA NA hsa-miR-182-5p DLG2 3.53923166221814 5.07781258121574e-21 -3.79723748090986 3.01897311382045e-14 miRNATAP -0.201897965137628 0.00137018119218625 NA NA NA hsa-miR-182-5p DPF3 3.53923166221814 5.07781258121574e-21 -1.66550931035639 8.31086463953742e-06 mirMAP -0.431626067604928 7.45952356366223e-23 NA NA NA hsa-miR-182-5p DTNA 3.53923166221814 5.07781258121574e-21 -4.06049121456747 1.59577306327407e-12 mirMAP -0.70899234440676 2.7123730955996e-25 NA NA NA hsa-miR-182-5p DUSP3 3.53923166221814 5.07781258121574e-21 -1.04472877082381 6.16231013810421e-12 mirMAP -0.216653786785627 3.30809852131513e-35 NA NA NA hsa-miR-182-5p DYNC1I1 3.53923166221814 5.07781258121574e-21 -2.0457299899893 0.00010088277927843 MirTarget -0.226263406387141 0.00046986586021078 NA NA NA hsa-miR-182-5p EBF1 3.53923166221814 5.07781258121574e-21 -2.88717194498131 2.67899786981751e-17 miRNATAP -0.418661867559774 2.33526428009822e-24 NA NA NA hsa-miR-182-5p EBF3 3.53923166221814 5.07781258121574e-21 -2.2154309523513 7.17493999444255e-11 MirTarget;miRNATAP -0.267781580131297 1.4094740368998e-10 NA NA NA hsa-miR-182-5p EDIL3 3.53923166221814 5.07781258121574e-21 -1.39552344263701 0.00540706010756216 MirTarget -0.292534452921023 1.64376711255295e-06 NA NA NA hsa-miR-182-5p EDNRB 3.53923166221814 5.07781258121574e-21 -2.52310122132934 4.0560560911117e-12 miRNATAP -0.224875799672555 6.74022156516521e-07 NA NA NA hsa-miR-182-5p EGR3 3.53923166221814 5.07781258121574e-21 -4.24788771954966 5.33225463207111e-21 MirTarget -0.520382869375895 6.38382912516321e-21 NA NA NA hsa-miR-182-5p EIF4E3 3.53923166221814 5.07781258121574e-21 -1.31017825340346 4.2763514565159e-09 mirMAP -0.109852630478514 7.08751162784412e-05 NA NA NA hsa-miR-182-5p EIF5A2 3.53923166221814 5.07781258121574e-21 -1.11920105116458 0.00497256140729196 mirMAP -0.348723735470338 2.39890488592298e-13 NA NA NA hsa-miR-182-5p ELL2 3.53923166221814 5.07781258121574e-21 -1.08408930026814 1.18240618311454e-05 MirTarget;miRNATAP -0.198755696588226 3.0017898489984e-11 NA NA NA hsa-miR-182-5p ELMO1 3.53923166221814 5.07781258121574e-21 -1.21325599380361 5.90368839878061e-05 MirTarget -0.302192286678394 3.78745340124829e-17 NA NA NA hsa-miR-129-5p ENDOD1 -0.524170159980738 0.222582956006346 -0.331902287589133 0.146465367778401 MirTarget;miRanda -0.101557070119569 9.90829354086753e-05 NA NA NA hsa-miR-130b-3p ENDOD1 3.5350292994509 1.73934183852569e-27 -0.331902287589133 0.146465367778401 MirTarget -0.135527686049539 1.78733250260079e-05 NA NA NA hsa-miR-16-1-3p ENDOD1 2.56983217111073 3.02262181237943e-20 -0.331902287589133 0.146465367778401 mirMAP -0.176726234672374 4.76351781243037e-06 NA NA NA hsa-miR-181c-5p ENDOD1 1.58587920618301 1.57506918816933e-10 -0.331902287589133 0.146465367778401 MirTarget -0.181825067072814 2.96443076151955e-05 NA NA NA hsa-miR-181d-5p ENDOD1 1.52204912185579 9.2693319057748e-08 -0.331902287589133 0.146465367778401 MirTarget -0.151516261359878 7.10308197865111e-05 NA NA NA hsa-miR-192-5p ENDOD1 2.69002528723195 1.22990188194432e-16 -0.331902287589133 0.146465367778401 miRNAWalker2_validate -0.157492739481784 1.21322938151644e-06 NA NA NA hsa-miR-19a-3p ENDOD1 3.42309334186656 3.02671914353412e-28 -0.331902287589133 0.146465367778401 mirMAP -0.138604025645659 2.7728778889914e-05 NA NA NA hsa-miR-19b-3p ENDOD1 2.49529833021187 1.57028265846699e-23 -0.331902287589133 0.146465367778401 mirMAP -0.189604053563397 5.4551020074105e-06 NA NA NA hsa-miR-20a-3p ENDOD1 2.92621109947706 2.49504904635375e-17 -0.331902287589133 0.146465367778401 MirTarget -0.114606991724655 0.000269835101992473 NA NA NA hsa-miR-26b-3p ENDOD1 2.18464160365372 2.11543189388328e-18 -0.331902287589133 0.146465367778401 mirMAP -0.136637022611884 0.00131032309806543 NA NA NA hsa-miR-301a-3p ENDOD1 2.81024345929638 2.29784847962242e-17 -0.331902287589133 0.146465367778401 MirTarget -0.134710930709202 6.44707125829365e-05 NA NA NA hsa-miR-3607-3p ENDOD1 2.68532138541128 5.66716351955047e-14 -0.331902287589133 0.146465367778401 MirTarget;miRNATAP -0.108599729502635 0.000404026567759276 NA NA NA hsa-miR-361-5p ENDOD1 0.971859117235239 5.30236555707088e-09 -0.331902287589133 0.146465367778401 MirTarget;miRanda -0.339022925897406 2.25093949414901e-07 NA NA NA hsa-miR-3613-5p ENDOD1 2.64358387329263 1.0373753017245e-24 -0.331902287589133 0.146465367778401 MirTarget -0.172750734082545 3.09318154778455e-05 NA NA NA hsa-miR-454-3p ENDOD1 2.47234127820054 1.12878018736016e-21 -0.331902287589133 0.146465367778401 MirTarget -0.199178296032197 1.5946167513499e-06 NA NA NA hsa-miR-590-3p ENDOD1 2.59289455139753 1.03200520972022e-21 -0.331902287589133 0.146465367778401 miRanda -0.150399397562406 0.00015650300787438 NA NA NA hsa-miR-182-5p ENTPD1 3.53923166221814 5.07781258121574e-21 -1.12219223948292 8.05257550730918e-10 mirMAP -0.263639157673808 1.39285542490782e-36 NA NA NA hsa-miR-182-5p EOMES 3.53923166221814 5.07781258121574e-21 -0.654957790276543 0.194942063904072 MirTarget -0.335333862627768 3.85814037105648e-08 NA NA NA hsa-miR-182-5p EPDR1 3.53923166221814 5.07781258121574e-21 -1.64105947206782 0.000351189669955332 MirTarget -0.467703509776766 7.95807935607664e-18 NA NA NA hsa-miR-182-5p EPHA3 3.53923166221814 5.07781258121574e-21 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.431286004950732 2.49229724892096e-18 NA NA NA hsa-miR-182-5p EPHA7 3.53923166221814 5.07781258121574e-21 -4.20206952913252 6.81894380739864e-12 miRNATAP -0.29396608789893 0.000124733367785231 NA NA NA hsa-miR-182-5p EPHB1 3.53923166221814 5.07781258121574e-21 -2.06632027088443 2.47699644252697e-06 MirTarget;miRNATAP -0.410556792921227 6.28130511261273e-15 NA NA NA hsa-miR-182-5p EPM2A 3.53923166221814 5.07781258121574e-21 -1.90233116870269 9.7764279872753e-23 miRNATAP -0.249093578477933 3.54663551481616e-26 NA NA NA hsa-miR-182-5p EPYC 3.53923166221814 5.07781258121574e-21 2.07054590791174 0.00523441030120972 MirTarget -0.361268428255123 6.69395876322745e-05 NA NA NA hsa-miR-182-5p ERG 3.53923166221814 5.07781258121574e-21 -1.3479378771967 2.23511589174121e-07 mirMAP -0.265659700435345 1.23871055142559e-17 NA NA NA hsa-miR-182-5p F13A1 3.53923166221814 5.07781258121574e-21 -2.67071497938806 3.96595860370351e-08 miRNATAP -0.601065983867808 4.93385294443841e-26 NA NA NA hsa-miR-182-5p FAM107A 3.53923166221814 5.07781258121574e-21 -5.00865420988181 1.32570913157414e-25 MirTarget -0.48069501601445 1.62563326105348e-15 NA NA NA hsa-miR-182-5p FAM124A 3.53923166221814 5.07781258121574e-21 -2.08623099443114 7.5264221195319e-08 mirMAP -0.465320749200241 1.80974399107619e-24 NA NA NA hsa-miR-182-5p FAM134B 3.53923166221814 5.07781258121574e-21 -1.39144367060901 0.000674691585504748 MirTarget;miRNATAP -0.192257182959281 0.000125934036509417 NA NA NA hsa-miR-182-5p FAM167A 3.53923166221814 5.07781258121574e-21 0.270294509636431 0.487790761066615 miRNATAP -0.166982558413956 0.000436377054515616 NA NA NA hsa-miR-182-5p FAM168A 3.53923166221814 5.07781258121574e-21 -0.715878355157019 0.0048087062534339 MirTarget -0.160066800352122 2.00399723557489e-07 NA NA NA hsa-miR-182-5p FAM171A1 3.53923166221814 5.07781258121574e-21 -1.60197929634559 3.82982438832311e-05 miRNATAP -0.20273194111507 2.15209502835312e-05 NA NA NA hsa-miR-182-5p FAM26E 3.53923166221814 5.07781258121574e-21 -1.51380317009881 3.60338715627852e-05 mirMAP -0.433334920586435 4.22036744913742e-24 NA NA NA hsa-miR-182-5p FAM78A 3.53923166221814 5.07781258121574e-21 -0.17566660865732 0.571673572062009 MirTarget;miRNATAP -0.270873057434249 2.2191718026889e-13 NA NA NA hsa-let-7a-5p FAS 0.618599506841644 2.76973453058748e-05 -0.893121037137088 0.00675655818216232 TargetScan -0.294996828851615 0.0073114418152214 NA NA NA hsa-miR-106a-5p FAS 2.48882002962836 1.99757727374521e-12 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate;miRTarBase -0.286433262215431 2.93487884151059e-11 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-23b-3p FAS -0.251132426825047 0.150200321210792 -0.893121037137088 0.00675655818216232 miRNATAP -0.391116610184141 2.37246599324584e-05 24356489 Moreover over-expression of Fas rescued the pro-proliferation effect of miR-23 indicating Fas is a direct mediator of miR-23 functions; Furthermore contrast to miR-23a/b which was up regulated the Fas expression level was down-regulated and inversely correlated with miR-23 in split radiation induced lymphoma tissue samples; Finally our data also indicates that miR-23a could repress Fas much more potent than miR-23b and the additional region besides conserved seed pairing enables miR-23a's higher regulation lymphoma hsa-miR-361-5p FAS 0.971859117235239 5.30236555707088e-09 -0.893121037137088 0.00675655818216232 miRanda -0.765596610913641 1.34005865686507e-16 NA NA NA hsa-miR-491-5p FAS 0.615770352820862 0.0418295628761654 -0.893121037137088 0.00675655818216232 miRanda -0.202143347610942 0.000355416125267629 NA NA NA hsa-miR-590-5p FAS 3.18300989862077 2.06813568597893e-26 -0.893121037137088 0.00675655818216232 miRanda -0.26445516527792 2.22188286955534e-07 NA NA NA hsa-miR-98-5p FAS 1.11154309866014 1.24143909012085e-08 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate -0.770550954607501 1.78193866759893e-23 NA NA NA hsa-let-7e-5p FASLG 0.860104282510173 6.04758298373779e-05 -0.196180452389551 0.711804379159628 miRNATAP -0.681095573446369 7.73237301751494e-09 NA NA NA hsa-miR-324-5p FASLG 2.95683728155095 1.32960514360912e-20 -0.196180452389551 0.711804379159628 miRanda -0.190742358117509 0.0133843611744564 NA NA NA hsa-miR-182-5p FAT3 3.53923166221814 5.07781258121574e-21 -2.79096679677476 3.40343867448209e-06 mirMAP -0.306222864244541 3.46821363548968e-05 NA NA NA hsa-miR-182-5p FBN1 3.53923166221814 5.07781258121574e-21 -1.81792584376713 5.27450945120085e-05 miRNATAP -0.54842784532456 9.57298560258998e-26 NA NA NA hsa-miR-182-5p FBXO32 3.53923166221814 5.07781258121574e-21 -0.934956145489406 0.00122406817472722 mirMAP -0.369929085845502 8.47824880204894e-29 NA NA NA hsa-miR-182-5p FER 3.53923166221814 5.07781258121574e-21 -0.960481943610693 0.000174638463493531 mirMAP -0.209315630731097 1.07463141602378e-11 NA NA NA hsa-miR-182-5p FGF9 3.53923166221814 5.07781258121574e-21 -4.26095125698269 8.03301928631002e-16 miRTarBase;miRNATAP -0.199763187583912 0.00291090860779188 NA NA NA hsa-miR-182-5p FMNL3 3.53923166221814 5.07781258121574e-21 0.138843294816209 0.460998322398368 miRNAWalker2_validate -0.15138267969285 1.61677869872247e-11 NA NA NA hsa-miR-182-5p FMO2 3.53923166221814 5.07781258121574e-21 -2.4057104016729 0.000137336354224179 MirTarget -0.648038684375853 4.46002914986829e-18 NA NA NA hsa-miR-182-5p FOXN3 3.53923166221814 5.07781258121574e-21 -1.43525991184281 2.70084540955391e-16 MirTarget;miRNATAP -0.153361540385543 1.51312923712541e-12 NA NA NA hsa-miR-182-5p FOXO1 3.53923166221814 5.07781258121574e-21 -1.06087355985292 3.97103810866528e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128361006344551 5.90064794890719e-08 24865442;26640590;23313739 Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;MiR 182 Is Associated with Growth Migration and Invasion in Prostate Cancer via Suppression of FOXO1; Our findings suggest that miR-182 may act to increase prostate cancer proliferation migration and invasion through suppression of FOXO1;Western blot flow cytometry and pathway analysis for the HeLa cells with miR-182 over/down-expression in vitro showed that miR-182 was involved in apoptosis and cell cycle pathways it also associated with the regulation of FOXO1 ;; colon cancer;prostate cancer;cervical and endocervical cancer hsa-miR-182-5p FOXP2 3.53923166221814 5.07781258121574e-21 -3.99353205302265 7.58170962329672e-11 miRNATAP -0.530829204108895 1.44997951932681e-12 NA NA NA hsa-miR-182-5p FYCO1 3.53923166221814 5.07781258121574e-21 -1.6226100593392 1.01871130782658e-16 miRNATAP -0.183561710505323 2.57227652800677e-14 NA NA NA hsa-miR-182-5p GAS7 3.53923166221814 5.07781258121574e-21 -2.67478964713793 6.70176551418169e-10 mirMAP -0.555065937334407 7.61011737566646e-28 NA NA NA hsa-miR-182-5p GCNT1 3.53923166221814 5.07781258121574e-21 0.0413031024334329 0.927473803129616 miRNATAP -0.273519857361614 6.25930709920995e-07 NA NA NA hsa-miR-182-5p GFOD1 3.53923166221814 5.07781258121574e-21 -0.940659645129877 0.00660758228917747 mirMAP -0.330905123891382 8.14364631945609e-16 NA NA NA hsa-miR-182-5p GIMAP1 3.53923166221814 5.07781258121574e-21 -1.23982274736301 6.11362537330939e-05 MirTarget -0.366718897096619 2.85143062383144e-24 NA NA NA hsa-miR-182-5p GJC1 3.53923166221814 5.07781258121574e-21 -0.972020676723743 0.00222017431601357 mirMAP -0.238173714559401 5.12686240176862e-10 NA NA NA hsa-miR-182-5p GLB1L 3.53923166221814 5.07781258121574e-21 -0.510508251671836 0.00564583070620466 MirTarget -0.135263992363863 1.11702019282309e-09 NA NA NA hsa-miR-182-5p GLI2 3.53923166221814 5.07781258121574e-21 -2.28902662613598 1.9678941791174e-06 MirTarget -0.513578930610023 2.39073152531938e-19 NA NA NA hsa-miR-182-5p GNG7 3.53923166221814 5.07781258121574e-21 -3.47904747202308 1.83990532659951e-21 mirMAP -0.33394588120831 3.25159373659616e-13 NA NA NA hsa-miR-182-5p GPR132 3.53923166221814 5.07781258121574e-21 -0.613688306043001 0.105694101529907 mirMAP -0.339176089989011 5.48889659247046e-14 NA NA NA hsa-miR-182-5p GPR183 3.53923166221814 5.07781258121574e-21 -2.34009544763103 5.97806938169407e-08 MirTarget -0.512234038448543 6.99577505702738e-24 NA NA NA hsa-miR-182-5p GPR3 3.53923166221814 5.07781258121574e-21 -0.959139062474991 0.000525741080276061 mirMAP -0.125103884553983 0.00022380431523227 NA NA NA hsa-miR-182-5p GPRASP2 3.53923166221814 5.07781258121574e-21 -1.4590659609289 3.45285620607504e-12 miRNATAP -0.199120059000491 5.96955483259228e-15 NA NA NA hsa-miR-182-5p GRIA3 3.53923166221814 5.07781258121574e-21 -2.06852702129128 7.47403992493886e-05 miRNATAP -0.448657144405691 9.05518728953662e-13 NA NA NA hsa-miR-182-5p GRID1 3.53923166221814 5.07781258121574e-21 -0.61772636758298 0.168665600534068 miRNATAP -0.19410121664038 0.000391239108098855 NA NA NA hsa-miR-182-5p GRIN2A 3.53923166221814 5.07781258121574e-21 -3.3233994538381 1.07825857067501e-08 mirMAP -0.433021080719212 1.17139439458597e-09 NA NA NA hsa-miR-182-5p GRIN3A 3.53923166221814 5.07781258121574e-21 -0.237867214305963 0.403188120647802 mirMAP -0.202175653573079 3.42067073886148e-09 NA NA NA hsa-miR-182-5p GXYLT2 3.53923166221814 5.07781258121574e-21 -1.72430339748435 0.00323225716692418 MirTarget -0.684651014234304 9.40082569277235e-24 NA NA NA hsa-miR-182-5p HBEGF 3.53923166221814 5.07781258121574e-21 -2.25664314425713 3.15709120593558e-11 MirTarget;miRNATAP -0.254157460078064 1.29310759383123e-09 NA NA NA hsa-miR-182-5p HDAC9 3.53923166221814 5.07781258121574e-21 -1.51871944408113 0.000720912761325448 miRNATAP -0.394470161664077 2.21525501148198e-13 26858310 HDAC Inhibition Induces MicroRNA 182 which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia; HR reporter assays apoptotic assays and colony-forming assays established that the miR-182 as well as the HDAC inhibition-mediated decreases in RAD51 inhibited HR repair and sensitized cells to sapacitabine; HDAC inhibition induced miR-182 in AML cell lines and primary AML blasts; Overexpression of miR-182 as well as HDAC inhibition-mediated induction of miR-182 were linked to time- and dose-dependent decreases in the levels of RAD51 an inhibition of HR increased levels of residual damage and decreased survival after exposure to double-strand damage-inducing agents; Our findings define the mechanism by which HDAC inhibition induces miR-182 to target RAD51 and highlights a novel pharmacologic strategy that compromises the ability of AML cells to conduct HR thereby sensitizing AML cells to DNA-damaging agents that activate HR as a repair and potential resistance mechanism poor survival;drug resistance acute myeloid leukemia hsa-miR-182-5p HIF3A 3.53923166221814 5.07781258121574e-21 -4.97932860856302 1.68517995562999e-14 mirMAP -0.59511946392683 8.93512712702467e-14 NA NA NA hsa-miR-182-5p HLA-DOA 3.53923166221814 5.07781258121574e-21 -0.788750104329619 0.0786620965309561 mirMAP -0.360017176205859 2.06197244488985e-11 NA NA NA hsa-miR-182-5p HMCN1 3.53923166221814 5.07781258121574e-21 -0.313432950411344 0.472274244820938 MirTarget -0.327137144574447 4.04828665487044e-10 NA NA NA hsa-miR-182-5p HOXA9 3.53923166221814 5.07781258121574e-21 -0.997610561961181 0.0549612762571718 miRNATAP -0.147586331187047 0.0206098194128181 NA NA NA hsa-miR-182-5p HSPA13 3.53923166221814 5.07781258121574e-21 -0.287922247159853 0.106347732939114 miRNATAP -0.104782630734016 1.18093143745574e-06 NA NA NA hsa-miR-182-5p IGSF10 3.53923166221814 5.07781258121574e-21 -5.30237641574688 9.03000767899905e-16 MirTarget -0.548815603409051 2.06756334138691e-11 NA NA NA hsa-miR-146b-5p IKBKB 1.75587235896724 1.15724631266659e-07 -0.00227190214342876 0.988714147115007 miRanda -0.12253940493918 7.13410135054121e-08 NA NA NA hsa-miR-182-5p IKZF1 3.53923166221814 5.07781258121574e-21 -1.30628932919626 0.00159566603720278 mirMAP -0.370913669378994 6.21105504306128e-14 NA NA NA hsa-miR-182-5p IL16 3.53923166221814 5.07781258121574e-21 -1.47099849326459 3.21424073431104e-07 mirMAP -0.308512240000045 1.83759901101031e-19 NA NA NA hsa-miR-182-5p IL17RD 3.53923166221814 5.07781258121574e-21 -1.40831642994976 1.59383539640135e-05 mirMAP -0.22992015538285 6.93949859285865e-09 NA NA NA hsa-miR-30d-3p IL1B 0.977747550180601 4.3048212205381e-05 0.039301070315787 0.942663363341787 MirTarget -0.351425913519885 0.00142656977660209 NA NA NA hsa-miR-130b-5p IL1R1 2.9963110846538 1.98883029416455e-18 -0.754392858754991 0.00819157634786962 mirMAP -0.265810866002561 8.60645196440847e-12 NA NA NA hsa-miR-17-3p IL1R1 2.2704817679209 1.1667437320211e-22 -0.754392858754991 0.00819157634786962 mirMAP -0.457437413596706 7.7813507528449e-17 NA NA NA hsa-miR-181b-5p IL1R1 2.49307679431293 3.92829250217627e-20 -0.754392858754991 0.00819157634786962 mirMAP -0.144149390460215 0.00312034364681948 NA NA NA hsa-miR-186-5p IL1R1 1.47445398888668 3.0781726595413e-15 -0.754392858754991 0.00819157634786962 mirMAP -0.413980327390447 6.22085295917803e-09 NA NA NA hsa-miR-192-5p IL1R1 2.69002528723195 1.22990188194432e-16 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.18623904564978 4.77161512216095e-06 NA NA NA hsa-miR-197-3p IL1R1 1.75733174019505 8.88576793100499e-13 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.245286619557537 6.97172291808552e-06 NA NA NA hsa-miR-24-3p IL1R1 0.99989036772428 1.35595013650376e-07 -0.754392858754991 0.00819157634786962 miRNATAP -0.329790317110319 4.8735388331152e-06 NA NA NA hsa-miR-26b-5p IL1R1 0.885393662798425 3.2116297961629e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.287058738544535 7.46900640431975e-05 NA NA NA hsa-miR-30d-3p IL1R1 0.977747550180601 4.3048212205381e-05 -0.754392858754991 0.00819157634786962 mirMAP -0.207730148083987 0.000312780009684164 NA NA NA hsa-miR-335-3p IL1R1 3.08791651139852 5.31309869723517e-12 -0.754392858754991 0.00819157634786962 mirMAP -0.128248188751599 1.75690264294768e-05 NA NA NA hsa-miR-361-5p IL1R1 0.971859117235239 5.30236555707088e-09 -0.754392858754991 0.00819157634786962 miRanda -0.498319115587793 9.79775892914811e-10 NA NA NA hsa-miR-590-3p IL1R1 2.59289455139753 1.03200520972022e-21 -0.754392858754991 0.00819157634786962 miRanda;miRNATAP -0.268420918425037 5.48871203423167e-08 NA NA NA hsa-miR-944 IL1R1 2.91186649218281 1.31574753528144e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.118403143401936 3.14768683036805e-07 NA NA NA hsa-miR-106a-5p IL1RAP 2.48882002962836 1.99757727374521e-12 0.687376288697117 0.0561773808581464 MirTarget -0.184285524641675 0.000113235346123953 NA NA NA hsa-miR-106b-5p IL1RAP 2.46782146831112 1.36171495805632e-23 0.687376288697117 0.0561773808581464 MirTarget -0.308359753412902 3.66029994017838e-06 NA NA NA hsa-miR-107 IL1RAP 1.30977326593435 1.30372468603965e-11 0.687376288697117 0.0561773808581464 miRanda -0.33678389768747 0.000139724034766597 NA NA NA hsa-miR-130b-3p IL1RAP 3.5350292994509 1.73934183852569e-27 0.687376288697117 0.0561773808581464 MirTarget -0.147309793399794 0.00330158193001679 NA NA NA hsa-miR-139-5p IL1RAP -1.52606598644743 1.20474151350665e-08 0.687376288697117 0.0561773808581464 miRanda -0.216871073158647 0.000708940318255466 NA NA NA hsa-miR-186-5p IL1RAP 1.47445398888668 3.0781726595413e-15 0.687376288697117 0.0561773808581464 mirMAP -0.248147291056268 0.0064761570270495 NA NA NA hsa-miR-190a-5p IL1RAP 0.762748400660219 0.0035950590410453 0.687376288697117 0.0561773808581464 MirTarget -0.193022328361973 0.00385457164001993 NA NA NA hsa-miR-192-5p IL1RAP 2.69002528723195 1.22990188194432e-16 0.687376288697117 0.0561773808581464 miRNAWalker2_validate -0.203023264982205 7.92657993381149e-05 NA NA NA hsa-miR-20b-5p IL1RAP 2.07706563022469 1.10107236083433e-05 0.687376288697117 0.0561773808581464 MirTarget -0.178499755018748 7.64252091780409e-07 NA NA NA hsa-miR-215-5p IL1RAP 2.30755467422978 2.38476032118039e-06 0.687376288697117 0.0561773808581464 miRNAWalker2_validate -0.140484900749653 9.91578317658242e-05 NA NA NA hsa-miR-29c-3p IL1RAP -0.00968972577705429 0.97099586346872 0.687376288697117 0.0561773808581464 MirTarget;miRNATAP -0.316780772059122 1.15292735023863e-06 NA NA NA hsa-miR-301a-3p IL1RAP 2.81024345929638 2.29784847962242e-17 0.687376288697117 0.0561773808581464 MirTarget -0.151958204710121 0.00446392491079674 NA NA NA hsa-miR-320a IL1RAP 0.438165828017084 0.0390159073347133 0.687376288697117 0.0561773808581464 MirTarget;PITA;miRanda -0.190631832000772 0.0213993725591207 NA NA NA hsa-miR-335-3p IL1RAP 3.08791651139852 5.31309869723517e-12 0.687376288697117 0.0561773808581464 mirMAP -0.116498433237795 0.00206868835534839 NA NA NA hsa-miR-361-5p IL1RAP 0.971859117235239 5.30236555707088e-09 0.687376288697117 0.0561773808581464 miRanda -0.278506548425349 0.00771310516085455 NA NA NA hsa-miR-421 IL1RAP 1.17791565395543 6.78526676976629e-06 0.687376288697117 0.0561773808581464 MirTarget;miRanda -0.191353033681468 0.00390232735089893 NA NA NA hsa-miR-454-3p IL1RAP 2.47234127820054 1.12878018736016e-21 0.687376288697117 0.0561773808581464 MirTarget -0.134476368406855 0.0422897667701867 NA NA NA hsa-miR-664a-3p IL1RAP 0.634721925861133 0.00520070178640421 0.687376288697117 0.0561773808581464 mirMAP -0.367234968888842 1.50065370650936e-06 NA NA NA hsa-miR-93-5p IL1RAP 3.03961860136032 1.11672209617395e-24 0.687376288697117 0.0561773808581464 MirTarget -0.289274250215671 1.35967607397858e-07 NA NA NA hsa-miR-182-5p IL6R 3.53923166221814 5.07781258121574e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.308185867210701 1.67894161264071e-10 NA NA NA hsa-miR-182-5p IL6ST 3.53923166221814 5.07781258121574e-21 -2.09967019941458 1.93264814611531e-05 mirMAP -0.422787250881008 9.05725280154988e-13 NA NA NA hsa-miR-1226-3p IRAK1 1.38118928579963 0.000205503474787488 0.6373544526515 0.00032590064915133 miRNAWalker2_validate -0.106240098169623 4.99256151870902e-05 NA NA NA hsa-miR-141-3p IRAK3 5.02396127982626 2.19224509139725e-24 -1.61324599744624 9.44362061411831e-07 mirMAP -0.237412262860539 1.63026403262395e-15 NA NA NA hsa-miR-148b-5p IRAK3 2.18024067300781 2.84770452413262e-14 -1.61324599744624 9.44362061411831e-07 mirMAP -0.337307253672073 2.92190660652579e-09 NA NA NA hsa-miR-16-1-3p IRAK3 2.56983217111073 3.02262181237943e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.217915579974644 0.000117601397835657 NA NA NA hsa-miR-16-2-3p IRAK3 2.31623086727196 4.29838149388188e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.241605828325225 7.32339791852684e-05 NA NA NA hsa-miR-16-5p IRAK3 1.75824877145857 1.68592440033108e-16 -1.61324599744624 9.44362061411831e-07 miRNAWalker2_validate -0.294716229106297 5.37676785444093e-05 NA NA NA hsa-miR-186-5p IRAK3 1.47445398888668 3.0781726595413e-15 -1.61324599744624 9.44362061411831e-07 mirMAP -0.520105007237852 3.24671297125945e-10 NA NA NA hsa-miR-188-5p IRAK3 2.52825126596644 6.78099435999778e-14 -1.61324599744624 9.44362061411831e-07 mirMAP -0.280672215201693 8.08975252886038e-09 NA NA NA hsa-miR-200a-3p IRAK3 4.59434485520731 6.38952518573476e-18 -1.61324599744624 9.44362061411831e-07 mirMAP -0.235202683293506 3.59384388778503e-17 NA NA NA hsa-miR-20a-3p IRAK3 2.92621109947706 2.49504904635375e-17 -1.61324599744624 9.44362061411831e-07 mirMAP -0.293239164748252 8.31399787795003e-11 NA NA NA hsa-miR-25-3p IRAK3 1.36472605225697 4.83790725935681e-11 -1.61324599744624 9.44362061411831e-07 mirMAP -0.486782496706321 8.60201865878405e-11 NA NA NA hsa-miR-29b-2-5p IRAK3 0.910668640983475 0.00666655585493488 -1.61324599744624 9.44362061411831e-07 mirMAP -0.225454736994109 2.14568944357781e-06 NA NA NA hsa-miR-32-5p IRAK3 2.34056473219422 6.24134585974322e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.328194671825066 3.51347516406062e-08 NA NA NA hsa-miR-3200-3p IRAK3 2.70510522077868 1.90469509928484e-08 -1.61324599744624 9.44362061411831e-07 mirMAP -0.268417657140478 2.21173595642778e-15 NA NA NA hsa-miR-320a IRAK3 0.438165828017084 0.0390159073347133 -1.61324599744624 9.44362061411831e-07 miRanda -0.177667111226484 0.0204343172413913 NA NA NA hsa-miR-320b IRAK3 1.55692969039548 1.41071034251915e-08 -1.61324599744624 9.44362061411831e-07 miRanda -0.254713964263451 9.45719838918495e-06 NA NA NA hsa-miR-324-5p IRAK3 2.95683728155095 1.32960514360912e-20 -1.61324599744624 9.44362061411831e-07 miRanda -0.351256984620892 8.27603616099315e-14 NA NA NA hsa-miR-326 IRAK3 0.715313016136042 0.0610265683213359 -1.61324599744624 9.44362061411831e-07 miRanda -0.11150566898433 0.00855072371022298 NA NA NA hsa-miR-330-3p IRAK3 0.876747334239085 0.00073709016089703 -1.61324599744624 9.44362061411831e-07 mirMAP -0.227895460995676 0.000226010351889401 NA NA NA hsa-miR-330-5p IRAK3 1.15100069700871 4.85551805046014e-07 -1.61324599744624 9.44362061411831e-07 miRanda -0.259104342543673 0.000204001879358591 NA NA NA hsa-miR-335-3p IRAK3 3.08791651139852 5.31309869723517e-12 -1.61324599744624 9.44362061411831e-07 mirMAP -0.15174104397747 1.29116664173015e-05 NA NA NA hsa-miR-33a-5p IRAK3 3.79671563098419 1.15966309820345e-18 -1.61324599744624 9.44362061411831e-07 mirMAP -0.263603831431637 4.66146319128517e-12 NA NA NA hsa-miR-361-5p IRAK3 0.971859117235239 5.30236555707088e-09 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.521687719341155 4.54616848788055e-08 NA NA NA hsa-miR-363-3p IRAK3 1.50575300026701 0.00020976164678918 -1.61324599744624 9.44362061411831e-07 mirMAP -0.176370169000037 6.63445963863957e-06 NA NA NA hsa-miR-421 IRAK3 1.17791565395543 6.78526676976629e-06 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.284717839538607 2.87793406686902e-06 NA NA NA hsa-miR-429 IRAK3 4.48815175680773 2.44117492218206e-17 -1.61324599744624 9.44362061411831e-07 miRanda -0.226880985621525 8.77354448488068e-16 NA NA NA hsa-miR-450b-5p IRAK3 1.69244418548325 1.68064054148881e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.268551151836279 5.89719539852997e-06 NA NA NA hsa-miR-501-5p IRAK3 1.93654809410041 1.3779381780759e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.296835101027037 2.37939188611957e-08 NA NA NA hsa-miR-505-3p IRAK3 1.45322244209148 8.86597629645867e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.253884740154823 0.000142204760654013 NA NA NA hsa-miR-589-3p IRAK3 2.51971841868825 2.39125940264107e-11 -1.61324599744624 9.44362061411831e-07 mirMAP -0.232633878464469 7.63598244506855e-07 NA NA NA hsa-miR-590-3p IRAK3 2.59289455139753 1.03200520972022e-21 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.260308402381023 6.83807609723304e-06 NA NA NA hsa-miR-590-5p IRAK3 3.18300989862077 2.06813568597893e-26 -1.61324599744624 9.44362061411831e-07 mirMAP -0.329211940694564 1.08651193118683e-10 NA NA NA hsa-miR-660-5p IRAK3 1.82692095272076 1.92040083607196e-13 -1.61324599744624 9.44362061411831e-07 mirMAP -0.313405787681777 5.64080920953627e-07 NA NA NA hsa-miR-7-1-3p IRAK3 1.84950311431067 1.25300363397654e-13 -1.61324599744624 9.44362061411831e-07 mirMAP -0.274128018063691 1.16665950411267e-05 NA NA NA hsa-miR-92a-3p IRAK3 2.06460102658973 1.44784291084757e-19 -1.61324599744624 9.44362061411831e-07 mirMAP -0.516491089062745 4.20857360213128e-15 NA NA NA hsa-miR-182-5p ISL1 3.53923166221814 5.07781258121574e-21 -2.91478963644857 6.12434734425048e-07 miRNATAP -0.263851805774181 0.000259709731523561 NA NA NA hsa-miR-182-5p ITGB8 3.53923166221814 5.07781258121574e-21 -0.771536596399464 0.078204531928335 MirTarget -0.165583568981071 0.00199407237884609 NA NA NA hsa-miR-182-5p ITPKB 3.53923166221814 5.07781258121574e-21 -1.70322432049595 4.43562078746451e-23 mirMAP -0.20631782230461 1.44085297075041e-22 NA NA NA hsa-miR-182-5p ITPR1 3.53923166221814 5.07781258121574e-21 -2.58213364075087 3.81753054779227e-18 miRNATAP -0.33429215603713 3.095472024721e-20 NA NA NA hsa-miR-182-5p JAKMIP3 3.53923166221814 5.07781258121574e-21 -2.48258063839244 3.80905318276763e-07 mirMAP -0.249054585102042 3.64338838498772e-05 NA NA NA hsa-miR-182-5p JAZF1 3.53923166221814 5.07781258121574e-21 -1.91995536790338 5.72076669427973e-12 MirTarget;miRNATAP -0.44522846180329 8.6791146417435e-46 NA NA NA hsa-miR-182-5p KCNJ12 3.53923166221814 5.07781258121574e-21 -2.26039929904991 2.90659346174232e-05 mirMAP -0.525005939768965 4.02395563370181e-16 NA NA NA hsa-miR-182-5p KCNJ2 3.53923166221814 5.07781258121574e-21 -0.281197518883409 0.36164514317052 miRNATAP -0.12619777379892 0.000786381028917242 NA NA NA hsa-miR-182-5p KCNQ5 3.53923166221814 5.07781258121574e-21 -3.67132504069307 1.90545533023382e-08 MirTarget -0.750744259911725 2.81882910264077e-22 NA NA NA hsa-miR-182-5p KDELC2 3.53923166221814 5.07781258121574e-21 -0.714539871567231 0.00145605854632104 MirTarget -0.177736731117618 4.49975398766198e-11 NA NA NA hsa-miR-182-5p KIAA1614 3.53923166221814 5.07781258121574e-21 -2.0146471536211 8.95131044809253e-13 mirMAP -0.39513550046192 1.77030235977227e-33 NA NA NA hsa-miR-182-5p KIAA2022 3.53923166221814 5.07781258121574e-21 -3.77781848258777 1.47825574429182e-12 miRNATAP -0.465350238388983 1.2232402502756e-12 NA NA NA hsa-miR-182-5p KIF19 3.53923166221814 5.07781258121574e-21 -2.22066031589261 1.60470538162673e-06 miRNATAP -0.39502852039163 1.62890561073816e-12 NA NA NA hsa-miR-182-5p KLF13 3.53923166221814 5.07781258121574e-21 -1.16141618366409 1.36372480238947e-05 MirTarget;miRNATAP -0.233345907627747 3.64889470487799e-13 NA NA NA hsa-miR-182-5p KLF7 3.53923166221814 5.07781258121574e-21 -0.396294178926278 0.170315776862033 MirTarget;miRNATAP -0.233347685936262 1.44917283942083e-11 NA NA NA hsa-miR-182-5p KLHL21 3.53923166221814 5.07781258121574e-21 -1.03680560428652 2.27490455113544e-07 mirMAP -0.172723849646445 9.58616530167698e-13 NA NA NA hsa-miR-182-5p KLHL4 3.53923166221814 5.07781258121574e-21 -2.04246744229493 0.00019958548677145 mirMAP -0.699431454969273 2.35111111967904e-28 NA NA NA hsa-miR-182-5p KPNA3 3.53923166221814 5.07781258121574e-21 -0.573359539342796 0.00262291748998806 MirTarget;miRNATAP -0.11168030244929 1.40482121370394e-06 NA NA NA hsa-miR-182-5p L1CAM 3.53923166221814 5.07781258121574e-21 -2.88244045420262 0.000237271593415049 MirTarget;miRNATAP -0.66799098737671 1.35697034079145e-12 NA NA NA hsa-miR-182-5p LAMC1 3.53923166221814 5.07781258121574e-21 -0.820359806292778 9.59613230767155e-05 miRNATAP -0.208617431877303 6.51660327570966e-17 NA NA NA hsa-miR-182-5p LIFR 3.53923166221814 5.07781258121574e-21 -2.63259527057529 1.38063075823569e-10 mirMAP -0.391394043860235 3.5767895328356e-15 NA NA NA hsa-miR-182-5p LIMS1 3.53923166221814 5.07781258121574e-21 -0.388381349388172 0.148139138497081 MirTarget;miRNATAP -0.116923567741085 0.000354221880553294 NA NA NA hsa-miR-182-5p LITAF 3.53923166221814 5.07781258121574e-21 -0.788929754767639 4.35306874197171e-05 MirTarget -0.155036090097895 2.65388234598928e-11 NA NA NA hsa-miR-182-5p LMOD1 3.53923166221814 5.07781258121574e-21 -4.98176884690939 5.21861914982847e-20 miRNATAP -0.789596210332783 1.09736087877131e-34 NA NA NA hsa-miR-182-5p LONRF2 3.53923166221814 5.07781258121574e-21 -3.8642101573018 7.90463940348435e-08 mirMAP -0.279876426960886 0.00173497697525483 NA NA NA hsa-miR-182-5p LPP 3.53923166221814 5.07781258121574e-21 -2.04092311415528 2.98839088727532e-15 MirTarget;miRNATAP -0.299012668479955 8.77736152999015e-22 NA NA NA hsa-miR-182-5p LRCH1 3.53923166221814 5.07781258121574e-21 -1.09367192084794 2.38111166969073e-11 MirTarget -0.184150427873521 4.18434560193655e-21 NA NA NA hsa-miR-182-5p LRCH2 3.53923166221814 5.07781258121574e-21 -2.83984975921435 2.14431508265196e-12 miRNATAP -0.445530377039467 5.12864424755453e-20 NA NA NA hsa-miR-182-5p LRP12 3.53923166221814 5.07781258121574e-21 -0.228599612770888 0.447188912695946 MirTarget -0.13880065071528 0.000149005246700917 NA NA NA hsa-miR-182-5p LRRC7 3.53923166221814 5.07781258121574e-21 -3.91787209255121 5.73746646820421e-15 MirTarget -0.316597493453036 4.75999125017864e-07 NA NA NA hsa-miR-182-5p MAF 3.53923166221814 5.07781258121574e-21 -1.28341922239874 0.00015825213662883 mirMAP;miRNATAP -0.353056657270293 1.56006706060078e-18 NA NA NA hsa-miR-182-5p MAFB 3.53923166221814 5.07781258121574e-21 -0.0500082844783902 0.882833918895083 mirMAP -0.276773306487276 8.37949462096353e-12 NA NA NA hsa-miR-182-5p MAGEL2 3.53923166221814 5.07781258121574e-21 -0.804281326553108 0.108198332126092 miRNATAP -0.14923986857643 0.0149809744777445 NA NA NA hsa-miR-182-5p MAN1A1 3.53923166221814 5.07781258121574e-21 -1.19565908364499 0.000880972558098608 MirTarget -0.157167235720871 0.000362309528154577 NA NA NA hsa-miR-182-5p MAP1A 3.53923166221814 5.07781258121574e-21 -2.81936532211288 1.95093328905874e-14 miRNATAP -0.534492901738045 7.54394576647017e-36 NA NA NA hsa-miR-182-5p MAP1B 3.53923166221814 5.07781258121574e-21 -3.18358434812783 4.83606017602339e-16 MirTarget;mirMAP;miRNATAP -0.549821540766757 8.3578263652054e-33 NA NA NA hsa-miR-106b-5p MAP3K14 2.46782146831112 1.36171495805632e-23 -0.929542138683687 1.31735308419243e-05 MirTarget -0.19000303078406 1.7530926860456e-06 NA NA NA hsa-miR-17-3p MAP3K14 2.2704817679209 1.1667437320211e-22 -0.929542138683687 1.31735308419243e-05 MirTarget -0.103035074073889 0.0162160477134261 NA NA NA hsa-miR-17-5p MAP3K14 3.2710598467455 9.93128340539455e-27 -0.929542138683687 1.31735308419243e-05 MirTarget -0.10840260212945 0.000682220817217628 NA NA NA hsa-miR-185-3p MAP3K14 2.3922478518806 1.3373426768452e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.129581834416974 6.081635091056e-05 NA NA NA hsa-miR-2110 MAP3K14 1.16625590651194 6.4784195289885e-05 -0.929542138683687 1.31735308419243e-05 MirTarget -0.119162411446147 0.00175262129581408 NA NA NA hsa-miR-331-3p MAP3K14 2.28379581858927 1.99663919173155e-18 -0.929542138683687 1.31735308419243e-05 MirTarget -0.177987296479208 2.93504280390057e-06 NA NA NA hsa-miR-34a-5p MAP3K14 1.9016323452565 1.43092834643601e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.168509021928338 3.5079349902853e-05 NA NA NA hsa-miR-423-5p MAP3K14 0.963563145758616 9.86109015204915e-07 -0.929542138683687 1.31735308419243e-05 MirTarget -0.153326623515501 0.003656927634938 NA NA NA hsa-miR-429 MAP3K14 4.48815175680773 2.44117492218206e-17 -0.929542138683687 1.31735308419243e-05 miRNATAP -0.149133359352813 2.41419963094442e-16 NA NA NA hsa-miR-874-3p MAP3K14 1.95617235160298 2.0152613104032e-12 -0.929542138683687 1.31735308419243e-05 MirTarget -0.1737967270095 1.57895892349653e-06 NA NA NA hsa-miR-93-5p MAP3K14 3.03961860136032 1.11672209617395e-24 -0.929542138683687 1.31735308419243e-05 MirTarget -0.141287388297998 1.8190573493729e-05 NA NA NA hsa-miR-182-5p MAP3K3 3.53923166221814 5.07781258121574e-21 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.192247148692721 4.9074620442185e-29 NA NA NA hsa-miR-182-5p MAP4K4 3.53923166221814 5.07781258121574e-21 0.130872521838526 0.522814141079271 MirTarget -0.104709849442277 2.49586396666125e-05 NA NA NA hsa-miR-182-5p MCFD2 3.53923166221814 5.07781258121574e-21 -0.273710952309139 0.0802130111446696 mirMAP -0.104983020204128 2.47013607649832e-08 NA NA NA hsa-miR-182-5p MDGA1 3.53923166221814 5.07781258121574e-21 -1.00154386684221 0.0303398006837731 mirMAP -0.392671602299597 1.20084967093431e-12 NA NA NA hsa-miR-182-5p MEF2C 3.53923166221814 5.07781258121574e-21 -2.13436808535659 1.07833769123274e-14 MirTarget;miRNATAP -0.364343251860128 6.0726616709347e-29 NA NA NA hsa-miR-182-5p MEF2D 3.53923166221814 5.07781258121574e-21 -1.254473345286 3.30937184393369e-26 miRNATAP -0.171263944894999 1.54261479458554e-33 NA NA NA hsa-miR-182-5p MITF 3.53923166221814 5.07781258121574e-21 -2.11043666647908 2.14681139044162e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.459685004473695 4.82335519155237e-29 19188590 In human tissues expression of miR-182 increases with progression from primary to metastatic melanoma and inversely correlates with FOXO3 and microphthalmia-associated transcription factor levels progression melanoma hsa-miR-182-5p MMD 3.53923166221814 5.07781258121574e-21 -0.0500962943374854 0.870546787744501 miRNATAP -0.235201708813205 1.68472873711789e-10 NA NA NA hsa-miR-182-5p MPP1 3.53923166221814 5.07781258121574e-21 -1.1646568248169 0.00139878541621182 miRNATAP -0.432923626680806 1.5988332386929e-24 NA NA NA hsa-miR-182-5p MRAS 3.53923166221814 5.07781258121574e-21 -1.30047814978706 1.21141012267765e-05 miRNATAP -0.350262585535789 7.07903170837591e-24 NA NA NA hsa-miR-182-5p MSN 3.53923166221814 5.07781258121574e-21 -0.85546319996218 0.0136615174636227 MirTarget -0.399550800387866 4.11732098452187e-23 NA NA NA hsa-miR-182-5p MYADM 3.53923166221814 5.07781258121574e-21 -2.82656540386901 8.49316181730987e-14 miRNATAP -0.512418905082231 1.04439196115464e-30 NA NA NA hsa-miR-182-5p MYO1E 3.53923166221814 5.07781258121574e-21 -0.243672932340454 0.248294329644903 mirMAP -0.111921593247605 1.2288284930221e-05 NA NA NA hsa-miR-182-5p MYOCD 3.53923166221814 5.07781258121574e-21 -5.66084293327068 2.02112506902108e-19 miRNATAP -0.723268982644115 4.47157933208955e-21 NA NA NA hsa-miR-182-5p NAMPT 3.53923166221814 5.07781258121574e-21 -1.01188888675403 7.98621574991513e-05 miRNATAP -0.150739445918225 1.4842347242114e-06 NA NA NA hsa-miR-182-5p NAV1 3.53923166221814 5.07781258121574e-21 -0.418200324441875 0.108742163308665 mirMAP -0.162499440053465 2.55093539261836e-07 NA NA NA hsa-miR-182-5p NCALD 3.53923166221814 5.07781258121574e-21 -2.321244587023 7.09583257149169e-15 miRNATAP -0.319688853781737 1.08863841581343e-18 NA NA NA hsa-miR-182-5p NCAM1 3.53923166221814 5.07781258121574e-21 -5.46812766536887 2.35522582039703e-18 miRNATAP -0.880539440508718 1.24572785948416e-32 NA NA NA hsa-miR-182-5p NCS1 3.53923166221814 5.07781258121574e-21 -1.7356703955299 3.35229307090603e-12 mirMAP -0.275068806780465 4.04979192928314e-20 NA NA NA hsa-miR-182-5p NECAB1 3.53923166221814 5.07781258121574e-21 -3.26252425353249 2.74412248921453e-12 MirTarget -0.573738700410589 3.87613007739481e-25 NA NA NA hsa-miR-182-5p NFASC 3.53923166221814 5.07781258121574e-21 -2.95717922837883 4.31475260476481e-14 mirMAP;miRNATAP -0.355661514772188 1.46622088784593e-13 NA NA NA hsa-miR-182-5p NFATC2 3.53923166221814 5.07781258121574e-21 -2.09940213646525 2.77134949511158e-05 mirMAP -0.274974364845855 7.50815876894642e-06 NA NA NA hsa-miR-182-5p NFE2L1 3.53923166221814 5.07781258121574e-21 -0.171483758009488 0.176829520001656 mirMAP -0.100221563463628 3.4665178436214e-11 NA NA NA hsa-miR-450b-5p NFKB1 1.69244418548325 1.68064054148881e-10 -0.64818153460532 4.948433163113e-05 MirTarget;PITA -0.124463449584444 1.35101416784659e-05 NA NA NA hsa-miR-92a-3p NFKB1 2.06460102658973 1.44784291084757e-19 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.146602812476967 6.42472618908431e-06 NA NA NA hsa-let-7a-5p NGF 0.618599506841644 2.76973453058748e-05 -2.40747957908931 8.29529053936123e-07 MirTarget;TargetScan -0.725600120025055 8.99703032904097e-06 NA NA NA hsa-let-7b-5p NGF 0.604314269683977 0.00140009936153214 -2.40747957908931 8.29529053936123e-07 MirTarget -0.445902124296935 0.000457128474125706 NA NA NA hsa-let-7d-5p NGF 1.33236798905207 1.1741085658466e-13 -2.40747957908931 8.29529053936123e-07 MirTarget -0.678554815907685 1.63174808684775e-07 NA NA NA hsa-let-7e-5p NGF 0.860104282510173 6.04758298373779e-05 -2.40747957908931 8.29529053936123e-07 MirTarget -0.426192872238101 0.000127971345995895 NA NA NA hsa-let-7f-5p NGF 0.495648727272215 0.00355972741198794 -2.40747957908931 8.29529053936123e-07 MirTarget -0.599266844830758 2.3727191387735e-05 NA NA NA hsa-let-7g-5p NGF 1.20061455355116 1.50237505511483e-12 -2.40747957908931 8.29529053936123e-07 MirTarget -1.06245785714021 3.64026543085871e-15 NA NA NA hsa-miR-125a-3p NGF 1.24490295132072 5.26925231010328e-06 -2.40747957908931 8.29529053936123e-07 miRanda -0.250797549188537 0.00395961103629666 NA NA NA hsa-miR-320a NGF 0.438165828017084 0.0390159073347133 -2.40747957908931 8.29529053936123e-07 miRanda -0.444107483987704 8.7035614427142e-05 NA NA NA hsa-miR-320b NGF 1.55692969039548 1.41071034251915e-08 -2.40747957908931 8.29529053936123e-07 miRanda -0.423772071383533 6.50389232533904e-07 NA NA NA hsa-miR-423-5p NGF 0.963563145758616 9.86109015204915e-07 -2.40747957908931 8.29529053936123e-07 MirTarget;miRNATAP -0.803354433746443 1.32594577043773e-11 NA NA NA hsa-miR-429 NGF 4.48815175680773 2.44117492218206e-17 -2.40747957908931 8.29529053936123e-07 miRanda -0.382290239888962 2.67088438561565e-20 NA NA NA hsa-miR-98-5p NGF 1.11154309866014 1.24143909012085e-08 -2.40747957908931 8.29529053936123e-07 MirTarget -0.660953034981452 3.88812196488546e-08 NA NA NA hsa-miR-182-5p NID1 3.53923166221814 5.07781258121574e-21 -0.986451929862748 0.00102953096063708 MirTarget -0.295454065439856 1.14089924295907e-16 NA NA NA hsa-miR-182-5p NLGN2 3.53923166221814 5.07781258121574e-21 -0.461039789162801 0.0537634389723614 miRNATAP -0.105498397867137 0.000295122792234236 NA NA NA hsa-miR-182-5p NOX4 3.53923166221814 5.07781258121574e-21 1.1573407399002 0.00254007513014407 miRNATAP -0.244352134211728 1.52467264829522e-07 NA NA NA hsa-miR-182-5p NPTX1 3.53923166221814 5.07781258121574e-21 -3.0548528465665 5.58655593069716e-09 miRNATAP -0.203865005867158 0.00178465104632102 NA NA NA hsa-miR-182-5p NR3C1 3.53923166221814 5.07781258121574e-21 -1.29490546417786 3.89055618845506e-05 miRNATAP -0.348761530594502 4.72913170211402e-21 NA NA NA hsa-miR-182-5p NTM 3.53923166221814 5.07781258121574e-21 -0.0757758455544759 0.858274223904391 miRTarBase -0.219419953630614 2.06309065493846e-05 NA NA NA hsa-miR-182-5p NTNG1 3.53923166221814 5.07781258121574e-21 -4.11654002819262 1.71914221059989e-10 MirTarget -0.681059239341281 1.52555929579791e-18 NA NA NA hsa-miR-182-5p NTRK2 3.53923166221814 5.07781258121574e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.542854638305866 3.89545557204651e-12 NA NA NA hsa-miR-182-5p NTRK3 3.53923166221814 5.07781258121574e-21 -5.17034960965042 5.23662623079398e-21 mirMAP -0.494727844384687 7.13881547217231e-13 NA NA NA hsa-miR-182-5p NUAK1 3.53923166221814 5.07781258121574e-21 0.329626043944068 0.281541076624495 MirTarget;miRNATAP -0.167269623337841 6.64789694611871e-06 NA NA NA hsa-miR-182-5p OOEP 3.53923166221814 5.07781258121574e-21 0.328110667201719 0.553202985043231 MirTarget -0.140272597093182 0.0384819359406382 NA NA NA hsa-miR-182-5p OPTN 3.53923166221814 5.07781258121574e-21 -0.238930465886824 0.283287504085888 MirTarget -0.171441225698603 1.26913598993335e-10 NA NA NA hsa-miR-182-5p PALLD 3.53923166221814 5.07781258121574e-21 -2.68837995750497 4.71973205022663e-15 MirTarget;miRNATAP -0.563766379986888 4.12381429318305e-48 NA NA NA hsa-miR-182-5p PAPPA 3.53923166221814 5.07781258121574e-21 -1.75955305841573 0.000134461135734203 MirTarget -0.341287001136072 9.68224374928512e-10 NA NA NA hsa-miR-182-5p PARM1 3.53923166221814 5.07781258121574e-21 -2.48542985552476 1.81540274264961e-10 MirTarget;miRNATAP -0.180368453367043 0.000206057096908734 NA NA NA hsa-miR-182-5p PAX6 3.53923166221814 5.07781258121574e-21 -0.0440427707484987 0.892699851474819 miRNATAP -0.106752555564538 0.00745383766555968 NA NA NA hsa-miR-182-5p PCDH10 3.53923166221814 5.07781258121574e-21 -3.23750023602778 3.50143209305191e-07 miRNATAP -0.517297538557891 2.02609152641839e-11 NA NA NA hsa-miR-182-5p PCDH17 3.53923166221814 5.07781258121574e-21 -0.31543828817169 0.277167062556602 miRNATAP -0.134867977002453 0.000134758176343061 NA NA NA hsa-miR-182-5p PCDH18 3.53923166221814 5.07781258121574e-21 -2.10799539281951 6.39285767196275e-11 MirTarget;miRNATAP -0.347131710517165 3.14739625192111e-19 NA NA NA hsa-miR-182-5p PCGF5 3.53923166221814 5.07781258121574e-21 -0.764423238295416 4.61130231454902e-07 miRNATAP -0.109016944750503 3.409035389269e-09 NA NA NA hsa-miR-182-5p PCOLCE2 3.53923166221814 5.07781258121574e-21 -4.92842826125534 3.75529487642829e-16 miRNAWalker2_validate -0.73624117085977 4.47098337633947e-24 NA NA NA hsa-miR-182-5p PDE1C 3.53923166221814 5.07781258121574e-21 -4.13701966391324 7.08661414779568e-16 mirMAP -0.60650560010366 1.00390501634832e-22 NA NA NA hsa-miR-182-5p PDE4D 3.53923166221814 5.07781258121574e-21 -2.16999194209536 1.89831164898157e-16 mirMAP -0.286053226995175 5.39367018882014e-19 NA NA NA hsa-miR-182-5p PDGFRA 3.53923166221814 5.07781258121574e-21 -2.37640583073564 1.39737819859365e-09 miRNATAP -0.375439590705967 2.48477058044486e-15 NA NA NA hsa-miR-182-5p PDPN 3.53923166221814 5.07781258121574e-21 -0.844865171556352 0.0581255733752544 MirTarget -0.343824754183795 1.3413236189011e-10 NA NA NA hsa-miR-182-5p PDZD4 3.53923166221814 5.07781258121574e-21 -3.50328419678476 5.69234493908284e-16 MirTarget;miRNATAP -0.404982921371749 3.18212888055154e-14 NA NA NA hsa-miR-182-5p PDZRN4 3.53923166221814 5.07781258121574e-21 -5.72101367483932 1.28426115579874e-16 miRNATAP -0.839726981433761 6.48190184990179e-24 NA NA NA hsa-miR-182-5p PHF19 3.53923166221814 5.07781258121574e-21 -0.569884194868888 0.0249085385065336 mirMAP -0.23503758353394 6.55264581197105e-15 NA NA NA hsa-miR-182-5p PHLDB1 3.53923166221814 5.07781258121574e-21 -0.688909556015726 0.00122355801941463 miRNATAP -0.193171316714041 2.84255608640527e-14 NA NA NA hsa-miR-182-5p PHYHIPL 3.53923166221814 5.07781258121574e-21 -1.3403818845059 0.020958999472695 miRNATAP -0.180920145746829 0.0110876182594979 NA NA NA hsa-miR-182-5p PIK3AP1 3.53923166221814 5.07781258121574e-21 -0.459059440376337 0.265936020481245 MirTarget -0.391785355726999 9.99609004314833e-16 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-miR-182-5p PLEKHH2 3.53923166221814 5.07781258121574e-21 -1.66246097253843 1.34981296620878e-06 MirTarget -0.232899423303958 3.01091844657952e-08 NA NA NA hsa-miR-182-5p PLOD2 3.53923166221814 5.07781258121574e-21 0.408783051727277 0.223517816964063 miRNATAP -0.264029735377106 5.17442693519629e-11 NA NA NA hsa-miR-182-5p PLXDC1 3.53923166221814 5.07781258121574e-21 0.00175712757885371 0.994886591921339 mirMAP -0.194459916449649 3.58734524047039e-09 NA NA NA hsa-miR-182-5p PLXNA4 3.53923166221814 5.07781258121574e-21 -2.25456361904941 4.96438419774251e-05 mirMAP -0.677276740478778 1.08010079860403e-25 NA NA NA hsa-miR-182-5p POU2F2 3.53923166221814 5.07781258121574e-21 -1.67646318583251 4.09542292476508e-07 miRNATAP -0.34801693236366 1.01767234142359e-18 NA NA NA hsa-miR-182-5p PPM1F 3.53923166221814 5.07781258121574e-21 -0.484267586694392 0.00139346420727647 MirTarget -0.127375934410954 2.03781885237881e-12 NA NA NA hsa-miR-182-5p PPP1R12A 3.53923166221814 5.07781258121574e-21 -1.33746384858456 3.3695937531748e-17 miRNATAP -0.190892950904658 1.53363916370312e-23 NA NA NA hsa-miR-182-5p PPP1R12B 3.53923166221814 5.07781258121574e-21 -3.46376452255787 1.1364412732345e-26 mirMAP -0.46153021585297 5.51358822046675e-32 NA NA NA hsa-let-7f-5p PPP3CA 0.495648727272215 0.00355972741198794 -0.281979431665802 0.0843014975757299 miRNATAP -0.145174821876866 0.00196996187493329 NA NA NA hsa-let-7g-5p PPP3CA 1.20061455355116 1.50237505511483e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.256650979931267 1.4045207283454e-08 NA NA NA hsa-miR-106a-5p PPP3CA 2.48882002962836 1.99757727374521e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.11191172835948 1.79556273427309e-07 NA NA NA hsa-miR-106b-5p PPP3CA 2.46782146831112 1.36171495805632e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.184105953911301 6.84398280050895e-10 NA NA NA hsa-miR-17-3p PPP3CA 2.2704817679209 1.1667437320211e-22 -0.281979431665802 0.0843014975757299 MirTarget -0.131133816129638 4.79999765543855e-05 NA NA NA hsa-miR-186-5p PPP3CA 1.47445398888668 3.0781726595413e-15 -0.281979431665802 0.0843014975757299 mirMAP -0.185694598107894 5.66511837519636e-06 NA NA NA hsa-miR-194-5p PPP3CA 1.8992998339217 3.76507853301977e-10 -0.281979431665802 0.0843014975757299 MirTarget -0.17070662815415 7.35898582017249e-12 NA NA NA hsa-miR-20a-5p PPP3CA 3.15577933619191 4.19753346442454e-25 -0.281979431665802 0.0843014975757299 miRNATAP -0.109419648077418 6.17460161232474e-06 NA NA NA hsa-miR-20b-5p PPP3CA 2.07706563022469 1.10107236083433e-05 -0.281979431665802 0.0843014975757299 miRNATAP -0.113387749946454 1.85473104688059e-12 NA NA NA hsa-miR-30c-5p PPP3CA 0.778774633108 0.000285599212429136 -0.281979431665802 0.0843014975757299 miRNATAP -0.212081199369466 4.85681407465908e-09 NA NA NA hsa-miR-30d-5p PPP3CA 0.675423997639582 0.00270618816039773 -0.281979431665802 0.0843014975757299 miRNATAP -0.142883121139453 4.34068465949306e-05 NA NA NA hsa-miR-501-3p PPP3CA 1.83132758513743 1.10971547702065e-10 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.114452652427796 2.34298968304304e-05 NA NA NA hsa-miR-502-3p PPP3CA 1.50560877085049 1.2647489756373e-11 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.15529134445823 7.08901270771209e-06 NA NA NA hsa-miR-664a-3p PPP3CA 0.634721925861133 0.00520070178640421 -0.281979431665802 0.0843014975757299 mirMAP -0.150747155909677 1.3336356409105e-05 NA NA NA hsa-miR-7-1-3p PPP3CA 1.84950311431067 1.25300363397654e-13 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP -0.119727173710851 9.40140707131449e-05 NA NA NA hsa-miR-93-3p PPP3CA 2.85383869771942 5.64481766902125e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.152353546507485 2.15079066361371e-09 NA NA NA hsa-miR-93-5p PPP3CA 3.03961860136032 1.11672209617395e-24 -0.281979431665802 0.0843014975757299 miRNATAP -0.156066415468858 2.44288871078656e-10 NA NA NA hsa-miR-107 PPP3CB 1.30977326593435 1.30372468603965e-11 -1.03671584843429 6.12489584217064e-15 miRanda -0.224024061633064 1.13198598297881e-11 NA NA NA hsa-miR-15a-5p PPP3CB 2.34669284378787 1.69544424500258e-23 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.188034579267018 6.2219880807044e-13 NA NA NA hsa-miR-15b-5p PPP3CB 1.57112623124278 9.14247846750597e-13 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.245380830384666 5.15260568991425e-18 NA NA NA hsa-miR-16-5p PPP3CB 1.75824877145857 1.68592440033108e-16 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.219222038672189 7.36535140884335e-14 NA NA NA hsa-miR-20a-3p PPP3CB 2.92621109947706 2.49504904635375e-17 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.113868623377048 9.37084199962394e-10 NA NA NA hsa-miR-26b-5p PPP3CB 0.885393662798425 3.2116297961629e-06 -1.03671584843429 6.12489584217064e-15 MirTarget;miRNATAP -0.129362759155204 0.000196474595826764 NA NA NA hsa-miR-30c-5p PPP3CB 0.778774633108 0.000285599212429136 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.165551300673001 5.92944884537219e-08 NA NA NA hsa-miR-30d-5p PPP3CB 0.675423997639582 0.00270618816039773 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.128345099197797 1.20380214861929e-05 NA NA NA hsa-miR-320a PPP3CB 0.438165828017084 0.0390159073347133 -1.03671584843429 6.12489584217064e-15 miRanda -0.133683103961461 1.89473747516991e-05 NA NA NA hsa-miR-320b PPP3CB 1.55692969039548 1.41071034251915e-08 -1.03671584843429 6.12489584217064e-15 miRanda -0.157984627594008 1.12882018634839e-11 NA NA NA hsa-miR-330-5p PPP3CB 1.15100069700871 4.85551805046014e-07 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.122279132326624 1.90117350044819e-05 NA NA NA hsa-miR-339-5p PPP3CB 2.68710938429893 3.03134080808154e-16 -1.03671584843429 6.12489584217064e-15 miRanda -0.129274316344838 1.00359131009696e-11 NA NA NA hsa-miR-361-5p PPP3CB 0.971859117235239 5.30236555707088e-09 -1.03671584843429 6.12489584217064e-15 miRanda -0.319599472524393 7.32960352437588e-17 NA NA NA hsa-miR-421 PPP3CB 1.17791565395543 6.78526676976629e-06 -1.03671584843429 6.12489584217064e-15 miRanda -0.107753543524587 1.70411972807069e-05 NA NA NA hsa-miR-429 PPP3CB 4.48815175680773 2.44117492218206e-17 -1.03671584843429 6.12489584217064e-15 miRanda -0.104170748345545 1.10824048087982e-19 NA NA NA hsa-miR-501-5p PPP3CB 1.93654809410041 1.3779381780759e-10 -1.03671584843429 6.12489584217064e-15 PITA;miRNATAP -0.110941325807012 4.19796167603695e-07 NA NA NA hsa-miR-590-3p PPP3CB 2.59289455139753 1.03200520972022e-21 -1.03671584843429 6.12489584217064e-15 miRanda -0.160737546369274 6.57567642585996e-12 NA NA NA hsa-miR-7-1-3p PPP3CB 1.84950311431067 1.25300363397654e-13 -1.03671584843429 6.12489584217064e-15 mirMAP -0.170702158890249 1.5272735318301e-11 NA NA NA hsa-miR-361-5p PPP3CC 0.971859117235239 5.30236555707088e-09 -0.895441456978914 1.07671854464434e-07 miRanda -0.275565592476708 1.65394541713718e-08 NA NA NA hsa-miR-500a-3p PPP3CC 1.47161373123699 5.30571342631915e-09 -0.895441456978914 1.07671854464434e-07 MirTarget;miRNATAP -0.11299814981742 0.000453955248711429 NA NA NA hsa-miR-502-3p PPP3CC 1.50560877085049 1.2647489756373e-11 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.137316418088144 0.000157963764790067 NA NA NA hsa-miR-101-3p PPP3R1 0.522819989585461 0.00375627731618038 -0.0284423401171923 0.760566460331176 miRNATAP -0.130896280595902 1.18496266678438e-07 NA NA NA hsa-miR-182-5p PRDM1 3.53923166221814 5.07781258121574e-21 -0.799773282697487 0.0106840144209139 miRNATAP -0.149673383161081 9.06896532328256e-05 NA NA NA hsa-miR-182-5p PRDM16 3.53923166221814 5.07781258121574e-21 -2.56004666228196 1.1360029849919e-06 mirMAP;miRNATAP -0.248249655306067 0.000131448197070304 NA NA NA hsa-miR-182-5p PRICKLE2 3.53923166221814 5.07781258121574e-21 -2.50492561876767 7.67759900282699e-16 MirTarget -0.402997008407211 1.15936336737611e-27 NA NA NA hsa-miR-182-5p PRKAA2 3.53923166221814 5.07781258121574e-21 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget;mirMAP -0.331706760870251 5.94483360132956e-07 NA NA NA hsa-let-7a-3p PRKACB 1.42015538786275 7.03375209382654e-13 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.21962130459547 5.79651670137419e-05 NA NA NA hsa-let-7b-3p PRKACB 0.868207752019623 1.30460056774366e-05 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.185130585565506 0.000844018426388941 NA NA NA hsa-let-7d-3p PRKACB 0.837345596411224 1.39469480391458e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.193122206370836 0.000761987397647901 NA NA NA hsa-let-7f-1-3p PRKACB 1.55054488387679 7.31326775537952e-11 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP -0.13342047017702 0.00451064067873152 NA NA NA hsa-miR-126-5p PRKACB 0.895338176458417 2.33372756450713e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.171245788041164 0.00102349617124601 NA NA NA hsa-miR-141-3p PRKACB 5.02396127982626 2.19224509139725e-24 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 NA NA NA hsa-miR-16-2-3p PRKACB 2.31623086727196 4.29838149388188e-20 -1.11910356116881 7.24897707751757e-07 mirMAP -0.211513116774948 3.56654687944943e-07 NA NA NA hsa-miR-17-5p PRKACB 3.2710598467455 9.93128340539455e-27 -1.11910356116881 7.24897707751757e-07 TargetScan -0.195594044734934 5.04690942157379e-09 NA NA NA hsa-miR-182-5p PRKACB 3.53923166221814 5.07781258121574e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.141282769334308 3.27226662914892e-07 NA NA NA hsa-miR-183-5p PRKACB 4.19757025992371 4.79612296318304e-26 -1.11910356116881 7.24897707751757e-07 MirTarget -0.132170429294976 3.08274590025093e-07 NA NA NA hsa-miR-18a-5p PRKACB 3.78535678765353 3.72446596213886e-26 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.170312158994311 1.8268780409686e-08 NA NA NA hsa-miR-193a-3p PRKACB 1.60460546928078 2.86169793322984e-07 -1.11910356116881 7.24897707751757e-07 miRanda -0.185097829574766 8.14913568795542e-08 NA NA NA hsa-miR-19a-3p PRKACB 3.42309334186656 3.02671914353412e-28 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.217127685863828 2.72225260525319e-11 NA NA NA hsa-miR-19b-3p PRKACB 2.49529833021187 1.57028265846699e-23 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.267352556269149 9.00420806048956e-11 NA NA NA hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 NA NA NA hsa-miR-2110 PRKACB 1.16625590651194 6.4784195289885e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.106141262528439 0.00882154187258127 NA NA NA hsa-miR-3065-5p PRKACB 2.74629919868982 1.86846589298284e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.103807774563958 0.000132862723321062 NA NA NA hsa-miR-30d-3p PRKACB 0.977747550180601 4.3048212205381e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.230639716646997 4.57613056559806e-07 NA NA NA hsa-miR-32-3p PRKACB 2.02436999565685 5.94091197945307e-09 -1.11910356116881 7.24897707751757e-07 mirMAP;miRNATAP -0.100714992594509 0.00471640544853458 NA NA NA hsa-miR-339-5p PRKACB 2.68710938429893 3.03134080808154e-16 -1.11910356116881 7.24897707751757e-07 miRanda -0.145165623596419 6.50854523117634e-06 NA NA NA hsa-miR-34a-5p PRKACB 1.9016323452565 1.43092834643601e-14 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.238915288481547 2.59419071561778e-08 NA NA NA hsa-miR-361-5p PRKACB 0.971859117235239 5.30236555707088e-09 -1.11910356116881 7.24897707751757e-07 miRanda -0.178114095699739 0.00724869450353386 NA NA NA hsa-miR-362-3p PRKACB 2.0756816987665 3.89026064579331e-12 -1.11910356116881 7.24897707751757e-07 PITA;miRanda;miRNATAP -0.2320492729467 2.29661541166603e-10 NA NA NA hsa-miR-362-5p PRKACB 1.59303749908759 9.582675908797e-08 -1.11910356116881 7.24897707751757e-07 PITA -0.194987590184185 6.59081906609811e-08 NA NA NA hsa-miR-3653-3p PRKACB 1.85886928622326 2.98407490336841e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.105612181380441 0.00210192398606289 NA NA NA hsa-miR-374a-5p PRKACB 0.484615721953736 0.0042981729815149 -1.11910356116881 7.24897707751757e-07 mirMAP -0.166638670031419 0.0116689154239509 NA NA NA hsa-miR-532-5p PRKACB 1.55697650978597 1.57884735535196e-11 -1.11910356116881 7.24897707751757e-07 PITA -0.27784223940084 1.83614058183971e-09 NA NA NA hsa-miR-590-3p PRKACB 2.59289455139753 1.03200520972022e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.20137371596257 3.58630956215221e-07 NA NA NA hsa-miR-590-5p PRKACB 3.18300989862077 2.06813568597893e-26 -1.11910356116881 7.24897707751757e-07 miRanda -0.22361088291547 1.69108646897883e-10 NA NA NA hsa-miR-7-1-3p PRKACB 1.84950311431067 1.25300363397654e-13 -1.11910356116881 7.24897707751757e-07 mirMAP -0.160819398581311 0.000186176032630634 NA NA NA hsa-miR-708-3p PRKACB 2.80907765282502 3.07460722669281e-14 -1.11910356116881 7.24897707751757e-07 mirMAP -0.107628106192083 0.000190951072862047 NA NA NA hsa-miR-93-5p PRKACB 3.03961860136032 1.11672209617395e-24 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate -0.194608106414379 2.15593790853491e-08 NA NA NA hsa-miR-96-5p PRKACB 4.89433085814374 1.92000659886961e-31 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.144257226112366 5.04306410867738e-09 NA NA NA hsa-miR-186-5p PRKAR1A 1.47445398888668 3.0781726595413e-15 -0.494707246064478 1.09832496534671e-05 mirMAP -0.158555937704806 1.81385800124173e-08 NA NA NA hsa-miR-25-3p PRKAR1A 1.36472605225697 4.83790725935681e-11 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.130633923717046 3.57662021897474e-07 NA NA NA hsa-miR-30b-5p PRKAR1A 0.800822374912712 0.000133601914525413 -0.494707246064478 1.09832496534671e-05 mirMAP -0.109738357042516 2.35678449980593e-05 NA NA NA hsa-miR-30c-5p PRKAR1A 0.778774633108 0.000285599212429136 -0.494707246064478 1.09832496534671e-05 mirMAP -0.117852671733036 3.18561702613009e-06 NA NA NA hsa-miR-30e-5p PRKAR1A 1.23904909539663 1.35561917122157e-09 -0.494707246064478 1.09832496534671e-05 mirMAP -0.13563514438677 2.13471830667205e-07 NA NA NA hsa-miR-103a-3p PRKAR2A 1.44083190496858 1.53799939616416e-13 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.350849310244118 1.94773064927018e-06 NA NA NA hsa-miR-106b-5p PRKAR2A 2.46782146831112 1.36171495805632e-23 -0.958058230501873 0.00166358416501506 mirMAP -0.242653924640786 1.85440556319997e-05 NA NA NA hsa-miR-125a-5p PRKAR2A 0.599529391575274 0.0102300147180307 -0.958058230501873 0.00166358416501506 miRanda -0.37787946708526 1.5675108729139e-09 NA NA NA hsa-miR-140-5p PRKAR2A 0.844753502512594 3.73722278438606e-05 -0.958058230501873 0.00166358416501506 miRanda -0.197853314212427 0.00623596481680405 NA NA NA hsa-miR-148a-3p PRKAR2A 1.26728238710376 2.52325607402829e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.173503602499007 0.00144323618557555 NA NA NA hsa-miR-148b-3p PRKAR2A 1.97815018171325 6.07715327281595e-26 -0.958058230501873 0.00166358416501506 mirMAP -0.308772207570419 3.36765416449186e-05 NA NA NA hsa-miR-16-5p PRKAR2A 1.75824877145857 1.68592440033108e-16 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.207299552214686 0.0020597428531192 NA NA NA hsa-miR-17-5p PRKAR2A 3.2710598467455 9.93128340539455e-27 -0.958058230501873 0.00166358416501506 mirMAP -0.213035467903906 2.30881349927684e-06 NA NA NA hsa-miR-182-5p PRKAR2A 3.53923166221814 5.07781258121574e-21 -0.958058230501873 0.00166358416501506 mirMAP -0.15304190547009 3.93441644995187e-05 NA NA NA hsa-miR-197-3p PRKAR2A 1.75733174019505 8.88576793100499e-13 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.19132087635181 0.00112031547705946 NA NA NA hsa-miR-20a-5p PRKAR2A 3.15577933619191 4.19753346442454e-25 -0.958058230501873 0.00166358416501506 mirMAP -0.262949466382429 5.45103485479054e-09 NA NA NA hsa-miR-21-5p PRKAR2A 2.73773305747971 1.38864982139576e-43 -0.958058230501873 0.00166358416501506 mirMAP -0.260585514930639 0.000114596506486694 NA NA NA hsa-miR-25-3p PRKAR2A 1.36472605225697 4.83790725935681e-11 -0.958058230501873 0.00166358416501506 mirMAP -0.199840197599522 0.00445130930358387 NA NA NA hsa-miR-26b-5p PRKAR2A 0.885393662798425 3.2116297961629e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.352489387774103 5.1180473461065e-06 NA NA NA hsa-miR-28-5p PRKAR2A 0.230152919654905 0.0742909586754846 -0.958058230501873 0.00166358416501506 miRanda -0.317354369876665 0.00743076146152275 NA NA NA hsa-miR-29a-5p PRKAR2A 1.46749674755271 3.34605004270294e-07 -0.958058230501873 0.00166358416501506 mirMAP -0.171509666685872 0.00142484408765363 NA NA NA hsa-miR-32-5p PRKAR2A 2.34056473219422 6.24134585974322e-20 -0.958058230501873 0.00166358416501506 mirMAP -0.164785528189658 0.00290913268502593 NA NA NA hsa-miR-320a PRKAR2A 0.438165828017084 0.0390159073347133 -0.958058230501873 0.00166358416501506 mirMAP -0.364222003224594 1.57087202982753e-07 NA NA NA hsa-miR-320b PRKAR2A 1.55692969039548 1.41071034251915e-08 -0.958058230501873 0.00166358416501506 mirMAP -0.199908717374264 0.00016060086703581 NA NA NA hsa-miR-342-5p PRKAR2A 1.74634624752902 3.89286511372155e-11 -0.958058230501873 0.00166358416501506 miRNATAP -0.245147904548481 7.00242952332571e-06 NA NA NA hsa-miR-3607-3p PRKAR2A 2.68532138541128 5.66716351955047e-14 -0.958058230501873 0.00166358416501506 mirMAP -0.168318445015138 4.10453820829504e-05 NA NA NA hsa-miR-361-5p PRKAR2A 0.971859117235239 5.30236555707088e-09 -0.958058230501873 0.00166358416501506 miRanda -0.193183161655923 0.0297877653345942 NA NA NA hsa-miR-3913-5p PRKAR2A 2.44353493655328 8.95279496632448e-15 -0.958058230501873 0.00166358416501506 mirMAP -0.201996350129065 1.42424912878332e-05 NA NA NA hsa-miR-582-3p PRKAR2A 0.00876844181512659 0.977126166214707 -0.958058230501873 0.00166358416501506 mirMAP -0.125770824276989 0.00964624611957725 NA NA NA hsa-miR-582-5p PRKAR2A 0.609226359812689 0.032988717891497 -0.958058230501873 0.00166358416501506 miRNATAP -0.204926721580595 7.24251105901293e-05 NA NA NA hsa-miR-590-5p PRKAR2A 3.18300989862077 2.06813568597893e-26 -0.958058230501873 0.00166358416501506 mirMAP -0.194427880221685 4.28778026268334e-05 NA NA NA hsa-miR-7-1-3p PRKAR2A 1.84950311431067 1.25300363397654e-13 -0.958058230501873 0.00166358416501506 mirMAP -0.173196690749086 0.00271404934063376 NA NA NA hsa-miR-769-3p PRKAR2A 2.19896922202687 5.69250370895053e-12 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.102240179808546 0.0286231702957129 NA NA NA hsa-miR-92a-3p PRKAR2A 2.06460102658973 1.44784291084757e-19 -0.958058230501873 0.00166358416501506 mirMAP -0.212779014359801 0.000625507145973245 NA NA NA hsa-let-7a-3p PRKAR2B 1.42015538786275 7.03375209382654e-13 -2.6424142214808 7.30155345842383e-13 mirMAP -0.413974785318944 4.57144286032067e-06 NA NA NA hsa-let-7b-3p PRKAR2B 0.868207752019623 1.30460056774366e-05 -2.6424142214808 7.30155345842383e-13 mirMAP -0.302979006252105 0.000989045305242101 NA NA NA hsa-let-7f-1-3p PRKAR2B 1.55054488387679 7.31326775537952e-11 -2.6424142214808 7.30155345842383e-13 mirMAP -0.215230558088131 0.00574393729251686 NA NA NA hsa-miR-107 PRKAR2B 1.30977326593435 1.30372468603965e-11 -2.6424142214808 7.30155345842383e-13 miRanda -0.231460940026043 0.0133239826950658 NA NA NA hsa-miR-186-5p PRKAR2B 1.47445398888668 3.0781726595413e-15 -2.6424142214808 7.30155345842383e-13 mirMAP -0.321761961201559 0.000772863763366889 NA NA NA hsa-miR-200b-3p PRKAR2B 3.78235093249346 3.18343003239465e-14 -2.6424142214808 7.30155345842383e-13 TargetScan -0.188581609073265 8.00246180754754e-08 NA NA NA hsa-miR-200c-3p PRKAR2B 3.50132673580082 2.42716349086937e-15 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.267488379876048 7.71967366135021e-12 NA NA NA hsa-miR-3065-5p PRKAR2B 2.74629919868982 1.86846589298284e-08 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.11341056331334 0.0122444126943186 NA NA NA hsa-miR-32-5p PRKAR2B 2.34056473219422 6.24134585974322e-20 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.276859835292248 5.01298329302752e-05 NA NA NA hsa-miR-335-3p PRKAR2B 3.08791651139852 5.31309869723517e-12 -2.6424142214808 7.30155345842383e-13 mirMAP -0.203129063258021 2.53679260832495e-07 NA NA NA hsa-miR-34c-3p PRKAR2B 2.41359195938096 3.46966584087088e-10 -2.6424142214808 7.30155345842383e-13 PITA;miRNATAP -0.138453766267301 0.00421688779281111 NA NA NA hsa-miR-361-5p PRKAR2B 0.971859117235239 5.30236555707088e-09 -2.6424142214808 7.30155345842383e-13 miRanda -0.392322571223063 0.000345653351775711 NA NA NA hsa-miR-429 PRKAR2B 4.48815175680773 2.44117492218206e-17 -2.6424142214808 7.30155345842383e-13 PITA;miRanda;miRNATAP -0.186608189782453 1.14936297941293e-08 NA NA NA hsa-miR-450b-5p PRKAR2B 1.69244418548325 1.68064054148881e-10 -2.6424142214808 7.30155345842383e-13 mirMAP;miRNATAP -0.137048468131565 0.0441799949298598 NA NA NA hsa-miR-590-3p PRKAR2B 2.59289455139753 1.03200520972022e-21 -2.6424142214808 7.30155345842383e-13 miRNAWalker2_validate;miRanda -0.269901854229474 4.28450511206591e-05 NA NA NA hsa-miR-92a-3p PRKAR2B 2.06460102658973 1.44784291084757e-19 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.464704311408613 9.32577627372663e-10 NA NA NA hsa-miR-944 PRKAR2B 2.91186649218281 1.31574753528144e-06 -2.6424142214808 7.30155345842383e-13 mirMAP -0.296024663700539 7.0750363003914e-24 NA NA NA hsa-miR-182-5p PRKD1 3.53923166221814 5.07781258121574e-21 -1.53164811371414 4.119038025094e-05 miRNATAP -0.210338416290666 4.21468202836352e-06 NA NA NA hsa-miR-182-5p PRRG1 3.53923166221814 5.07781258121574e-21 -0.464304628644506 0.115609951928287 mirMAP -0.153574374175986 1.84995631885687e-05 NA NA NA hsa-miR-182-5p PRUNE2 3.53923166221814 5.07781258121574e-21 -4.80598803189319 1.66841624992026e-13 miRNATAP -0.96625211517253 7.53487864798096e-38 NA NA NA hsa-miR-182-5p PRX 3.53923166221814 5.07781258121574e-21 -1.40075382104523 1.17274413921886e-10 mirMAP -0.160775002420511 1.8047978567658e-09 NA NA NA hsa-miR-182-5p PTGER3 3.53923166221814 5.07781258121574e-21 -3.17892614473001 1.0932904794636e-07 miRNATAP -0.637016336152709 4.19821656682483e-19 NA NA NA hsa-miR-182-5p PTGFR 3.53923166221814 5.07781258121574e-21 -4.31417785205749 1.80615933126723e-13 MirTarget -0.774702010804082 3.21951695927932e-29 NA NA NA hsa-miR-182-5p PTHLH 3.53923166221814 5.07781258121574e-21 -0.637337427958821 0.359541326845111 MirTarget -0.410558056926388 1.10216659777992e-06 NA NA NA hsa-miR-182-5p PTP4A1 3.53923166221814 5.07781258121574e-21 -0.886199664882353 4.27122299209568e-05 miRNATAP -0.118531023202364 7.66767324737065e-06 NA NA NA hsa-miR-182-5p PTPRG 3.53923166221814 5.07781258121574e-21 -0.659570164498502 0.0398812996716316 MirTarget;miRNATAP -0.1963272444908 4.46053310509134e-07 NA NA NA hsa-miR-182-5p QKI 3.53923166221814 5.07781258121574e-21 -0.459712923996318 0.00440824124371165 mirMAP -0.135684485978041 1.98353534000198e-12 NA NA NA hsa-miR-182-5p RAB11FIP5 3.53923166221814 5.07781258121574e-21 -0.275218903695492 0.0980214449037859 miRNATAP -0.110448541717746 3.51864717565856e-08 NA NA NA hsa-miR-182-5p RAB31 3.53923166221814 5.07781258121574e-21 -0.565488704793941 0.0757768686383417 mirMAP -0.369144048511619 1.62312647501591e-23 NA NA NA hsa-miR-182-5p RAB34 3.53923166221814 5.07781258121574e-21 -0.536697359666198 0.10714948591148 miRNATAP -0.169333471179939 2.92497307970239e-05 NA NA NA hsa-miR-182-5p RAPGEF5 3.53923166221814 5.07781258121574e-21 -0.580986175597244 0.0366906480299328 MirTarget -0.164378855734397 1.09181602237902e-06 NA NA NA hsa-miR-182-5p RASGRF2 3.53923166221814 5.07781258121574e-21 -0.959101466033611 0.00295453490406439 mirMAP -0.280032478581552 3.94983090544796e-13 NA NA NA hsa-miR-182-5p RBPMS 3.53923166221814 5.07781258121574e-21 -1.76986611936615 2.10521492077454e-10 mirMAP -0.163253875178284 2.26950968720443e-06 NA NA NA hsa-miR-182-5p RDX 3.53923166221814 5.07781258121574e-21 -0.333782953922244 0.221635333144355 MirTarget;miRNATAP -0.114580993744112 0.000578440056629381 NA NA NA hsa-miR-182-5p RECK 3.53923166221814 5.07781258121574e-21 -2.38610578026315 7.82688892259109e-14 miRNAWalker2_validate;miRNATAP -0.401952252290376 3.00734108680527e-26 23226455;27648365;23333633 We also identified Smad4 and RECK as potential target genes of miR-182-5p using several algorithms; In conclusion our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4 resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer;In our previous results we demonstrated that miR-182 was over-expressed in breast cancer cell lines and clinical tumor tissues and its up-regulation increased tumorigenicity and invasiveness by repressing a tumor suppressor RECK;Up regulation of miR 182 by β catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK; The correlation between miR-182 and RECK was analyzed by Western blotting real-time RT-PCR and 3'-untranslated region reporter assay; Ectopic expression of miR-182 inhibited restoration of RECK protein by β-catenin inhibitor indicating miR-182 is important for β-catenin-induced down-regulation of RECK; An inverse association between miR-182 and RECK was demonstrated in breast tumor tissues; We provide evidence that miR-182 is up-regulated by β-catenin signaling pathway in breast cancer and its up-regulation increases tumorigenicity and invasiveness by repressing RECK; In addition we identify a new miR-182 target RECK which is important for miR-182-induced tumorigenesis ;;tumorigenesis bladder cancer;breast cancer;breast cancer hsa-miR-182-5p REEP1 3.53923166221814 5.07781258121574e-21 -4.34753961523252 3.78306600846853e-15 miRNATAP -0.568011258020081 4.05621459049462e-17 NA NA NA hsa-miR-182-5p RELL1 3.53923166221814 5.07781258121574e-21 -0.699510059379432 0.000153337737223854 MirTarget -0.132276452334424 3.30154061700793e-09 NA NA NA hsa-miR-182-5p RFTN1 3.53923166221814 5.07781258121574e-21 -0.515091372232221 0.0525029974344917 miRNATAP -0.23800735443647 4.86374952090027e-14 NA NA NA hsa-miR-182-5p RGL1 3.53923166221814 5.07781258121574e-21 -1.51925487686695 6.14848968356696e-09 MirTarget -0.280987384646267 2.05586290564071e-19 NA NA NA hsa-miR-182-5p RGS5 3.53923166221814 5.07781258121574e-21 -2.66173182333744 1.67220114552801e-13 MirTarget -0.237763498939591 1.25758549604338e-07 NA NA NA hsa-miR-182-5p RIMBP2 3.53923166221814 5.07781258121574e-21 -2.69405047193145 5.63343241147361e-07 mirMAP;miRNATAP -0.297999288979254 6.93851875827488e-06 NA NA NA hsa-miR-182-5p RIMS3 3.53923166221814 5.07781258121574e-21 -1.42027619315578 3.00440701262036e-05 MirTarget;miRNATAP -0.196768199322744 2.29735746598719e-06 NA NA NA hsa-miR-182-5p RIN3 3.53923166221814 5.07781258121574e-21 -0.542708773196135 0.0113680652033468 mirMAP -0.240740455203217 5.81028498606835e-22 NA NA NA hsa-miR-182-5p RNF212 3.53923166221814 5.07781258121574e-21 -2.78983710949886 1.11878098033565e-08 MirTarget -0.381270058210798 1.66237576886054e-10 NA NA NA hsa-miR-182-5p RNF217 3.53923166221814 5.07781258121574e-21 -1.13715450185669 0.0097437081213251 mirMAP -0.362563869680168 6.16119274692539e-12 NA NA NA hsa-miR-182-5p ROCK1 3.53923166221814 5.07781258121574e-21 -1.02661670614902 1.94754524728051e-09 MirTarget -0.129367164013929 6.18056517206253e-10 NA NA NA hsa-miR-182-5p RRAGD 3.53923166221814 5.07781258121574e-21 -1.28210533175691 5.97051882858326e-05 mirMAP -0.226125984810836 5.51093347185599e-09 NA NA NA hsa-miR-182-5p RUNDC3B 3.53923166221814 5.07781258121574e-21 -2.34766072113968 4.25783257641366e-15 miRNATAP -0.209140456565893 2.15275397383635e-08 NA NA NA hsa-miR-182-5p RUNX1T1 3.53923166221814 5.07781258121574e-21 -3.29112409449622 2.69681218718585e-11 mirMAP -0.540180397526602 8.27196285329787e-20 NA NA NA hsa-miR-182-5p SAMD4A 3.53923166221814 5.07781258121574e-21 -2.17607774370782 7.9670339471712e-12 MirTarget;miRNATAP -0.431739952671371 2.74467874432483e-31 NA NA NA hsa-miR-182-5p SCN2A 3.53923166221814 5.07781258121574e-21 -1.29167455183038 0.0301757402573598 miRNATAP -0.341078549639938 2.46746883642958e-06 NA NA NA hsa-miR-182-5p SCN3A 3.53923166221814 5.07781258121574e-21 -2.32699009748223 7.40591172107087e-07 miRNATAP -0.313753294912719 4.91119771804196e-08 NA NA NA hsa-miR-182-5p SCN4B 3.53923166221814 5.07781258121574e-21 -2.75295017691825 5.60438848890772e-15 mirMAP -0.259760998997352 3.26788989818682e-09 NA NA NA hsa-miR-182-5p SCN9A 3.53923166221814 5.07781258121574e-21 -1.38434426315237 0.00934391039271171 mirMAP;miRNATAP -0.251482434683206 0.000111171555446994 NA NA NA hsa-miR-182-5p SCRN1 3.53923166221814 5.07781258121574e-21 -0.564649180285022 0.0489255478589769 mirMAP -0.201328269103519 5.677477095992e-09 NA NA NA hsa-miR-182-5p SCUBE3 3.53923166221814 5.07781258121574e-21 -2.48127471582544 2.66234551923326e-07 miRNATAP -0.366193976989197 4.60952345680499e-10 NA NA NA hsa-miR-182-5p SDC2 3.53923166221814 5.07781258121574e-21 -2.00706478458987 1.28300608152733e-09 miRNATAP -0.329370187889486 1.36307943900447e-16 NA NA NA hsa-miR-182-5p SETBP1 3.53923166221814 5.07781258121574e-21 -2.26227903514797 8.87237114441678e-09 mirMAP -0.350919867085126 1.85601162847403e-13 NA NA NA hsa-miR-182-5p SETD7 3.53923166221814 5.07781258121574e-21 -1.13463057726458 1.78342966519954e-10 MirTarget;miRNATAP -0.213594347414529 2.79528304630975e-24 NA NA NA hsa-miR-182-5p SETX 3.53923166221814 5.07781258121574e-21 -0.708007818270648 2.86307552568454e-08 MirTarget;miRNATAP -0.110128178390888 8.56347378784709e-13 NA NA NA hsa-miR-182-5p SFRP1 3.53923166221814 5.07781258121574e-21 -4.72165743596444 1.94213340952985e-11 mirMAP -0.689760445961909 6.52748321080623e-16 NA NA NA hsa-miR-182-5p SGCB 3.53923166221814 5.07781258121574e-21 -1.44760592804974 4.88730706418823e-10 mirMAP -0.327112075589339 2.52618191762848e-34 NA NA NA hsa-miR-182-5p SGMS2 3.53923166221814 5.07781258121574e-21 -1.36680165019397 1.86579437284973e-05 MirTarget;miRNATAP -0.343609876146844 8.54441599087068e-20 NA NA NA hsa-miR-182-5p SH2D1A 3.53923166221814 5.07781258121574e-21 -1.10597424227522 0.0293424555172639 MirTarget;miRNATAP -0.372541578671597 1.10440891703557e-09 NA NA NA hsa-miR-182-5p SH3BGRL 3.53923166221814 5.07781258121574e-21 -1.43100123895073 2.53257963935967e-09 MirTarget -0.220896460763939 2.94731576682063e-14 NA NA NA hsa-miR-182-5p SH3PXD2A 3.53923166221814 5.07781258121574e-21 -0.987155493438988 1.02406192375196e-05 mirMAP -0.172318606957502 2.01025496675354e-10 NA NA NA hsa-miR-182-5p SH3PXD2B 3.53923166221814 5.07781258121574e-21 -0.53998931418926 0.0139175585788792 miRNATAP -0.182566396150399 3.55002717830252e-12 NA NA NA hsa-miR-182-5p SH3RF3 3.53923166221814 5.07781258121574e-21 -1.68472949721979 5.44492695285492e-08 MirTarget -0.375845225006747 4.84341397806321e-25 NA NA NA hsa-miR-182-5p SHC4 3.53923166221814 5.07781258121574e-21 -0.664061852285107 0.0809797980708126 MirTarget;miRNATAP -0.221370731435305 1.61837528879945e-06 NA NA NA hsa-miR-182-5p SHROOM3 3.53923166221814 5.07781258121574e-21 -1.26167822754868 0.000636872985591942 mirMAP -0.193814049611371 1.76856078260864e-05 NA NA NA hsa-miR-182-5p SIK2 3.53923166221814 5.07781258121574e-21 -0.895905910195029 1.03810013473188e-10 mirMAP -0.118140205275128 2.57240219798893e-12 NA NA NA hsa-miR-182-5p SLC1A2 3.53923166221814 5.07781258121574e-21 -1.63926856184029 0.00011983867188635 MirTarget;miRNATAP -0.167826996575068 0.00137551386193892 NA NA NA hsa-miR-182-5p SLC2A3 3.53923166221814 5.07781258121574e-21 -2.09454232135098 3.92772896271437e-08 MirTarget -0.383138056908853 5.19460392670154e-17 NA NA NA hsa-miR-182-5p SLC6A17 3.53923166221814 5.07781258121574e-21 0.941104200796897 0.0568131902197341 mirMAP -0.288512156747641 1.4954201161374e-06 NA NA NA hsa-miR-182-5p SLC7A2 3.53923166221814 5.07781258121574e-21 -1.40305887660435 0.00128606407427126 mirMAP -0.114482246955911 0.0329630048458994 NA NA NA hsa-miR-182-5p SLCO2B1 3.53923166221814 5.07781258121574e-21 -0.857147486993845 0.0465370602382169 MirTarget -0.511094330687764 1.13131700683799e-24 NA NA NA hsa-miR-182-5p SLCO3A1 3.53923166221814 5.07781258121574e-21 -0.349114583112527 0.300053914964445 MirTarget;miRNATAP -0.15105445912022 0.000232143455879123 NA NA NA hsa-miR-182-5p SLITRK4 3.53923166221814 5.07781258121574e-21 -2.22318009296394 0.000124335481622699 MirTarget;miRNATAP -0.490211833525425 2.00715993704635e-12 NA NA NA hsa-miR-182-5p SMAD7 3.53923166221814 5.07781258121574e-21 -1.18986730797292 6.37278457783496e-08 miRNATAP -0.139835996687329 2.24704056840338e-07 NA NA NA hsa-miR-182-5p SNAI2 3.53923166221814 5.07781258121574e-21 -0.280307189347724 0.489884936104145 miRNAWalker2_validate;miRNATAP -0.226684880391696 4.11330558077327e-06 NA NA NA hsa-miR-182-5p SNX29 3.53923166221814 5.07781258121574e-21 -0.637224583441126 6.77957051876116e-05 mirMAP -0.129045948935314 2.00024745426939e-11 NA NA NA hsa-miR-182-5p SOX5 3.53923166221814 5.07781258121574e-21 -2.80899915084138 3.69546336813367e-12 miRNATAP -0.339154870096328 8.52822195836199e-12 NA NA NA hsa-miR-182-5p SOX6 3.53923166221814 5.07781258121574e-21 -2.16170894059309 7.49520430040923e-06 miRNATAP -0.194005093120807 0.00112779147110448 NA NA NA hsa-miR-182-5p ST3GAL3 3.53923166221814 5.07781258121574e-21 -1.09370616658902 5.68245266413635e-09 mirMAP -0.165846014156959 3.02448155461591e-13 NA NA NA hsa-miR-182-5p ST6GALNAC3 3.53923166221814 5.07781258121574e-21 -2.04578308207892 3.03442932816697e-11 mirMAP -0.249758834218924 3.81951869242818e-11 NA NA NA hsa-miR-182-5p STARD13 3.53923166221814 5.07781258121574e-21 -2.17932975894295 1.5776545031728e-14 miRNATAP -0.411832828424052 6.82114383675963e-36 NA NA NA hsa-miR-182-5p STAT1 3.53923166221814 5.07781258121574e-21 0.542663454678779 0.0737713250641883 mirMAP -0.163334442311918 9.45184839156753e-06 NA NA NA hsa-miR-182-5p STC1 3.53923166221814 5.07781258121574e-21 -1.55340441030689 1.29077994156941e-05 miRNATAP -0.230472760529581 1.14762757177164e-07 NA NA NA hsa-miR-182-5p STK17A 3.53923166221814 5.07781258121574e-21 -0.23852001224455 0.313522804067474 miRNATAP -0.155317324198671 5.21647695556427e-08 NA NA NA hsa-miR-182-5p STK17B 3.53923166221814 5.07781258121574e-21 -0.462761081076055 0.0431834704534941 miRNATAP -0.155278454825387 1.85901716321481e-08 NA NA NA hsa-miR-182-5p STX1B 3.53923166221814 5.07781258121574e-21 -0.831193288425681 0.0477395804955152 mirMAP -0.336363473190289 2.30693227072617e-11 NA NA NA hsa-miR-182-5p STXBP6 3.53923166221814 5.07781258121574e-21 -3.29735555779228 1.4741858431786e-07 mirMAP -0.313518905989811 5.26414006289328e-05 NA NA NA hsa-miR-182-5p SV2B 3.53923166221814 5.07781258121574e-21 -2.33341367960543 7.07116491599061e-05 mirMAP -0.573035878584313 2.59940915410328e-16 NA NA NA hsa-miR-182-5p TACC1 3.53923166221814 5.07781258121574e-21 -1.71010964840655 3.78195172257726e-09 MirTarget;miRNATAP -0.171376503186908 1.74200234186493e-06 NA NA NA hsa-miR-182-5p TAF4B 3.53923166221814 5.07781258121574e-21 -0.440551340182907 0.163919692677726 MirTarget;miRNATAP -0.122866264441996 0.00147563792485391 NA NA NA hsa-miR-182-5p TCEAL7 3.53923166221814 5.07781258121574e-21 -3.24676947087228 8.59713834221883e-18 MirTarget -0.408241484672296 1.10534399715066e-18 24021963 The purpose of this study was to examine the role of microRNA-182 and its target gene transcription elongation factor A-like 7 TCEAL7 in EC; The expression of miR-182 in human normal endometrial epithelial cells NEEC and in three human endometrial carcinoma cell lines HEC-1B RL95-2 and AN3CA was measured by qRT-PCR and the mRNA and protein expression of TCEAL7 were assessed in the same three endometrial carcinoma cell lines and NEEC by qRT-PCR and western blotting respectively; MiR-182 was significantly upregulated and TCEAL7 was downregulated in EC cell lines compared to NEEC endometrial cancer hsa-miR-182-5p TEAD1 3.53923166221814 5.07781258121574e-21 -1.49495998391161 1.96516757915294e-13 mirMAP;miRNATAP -0.208311227035654 3.08897671904962e-17 NA NA NA hsa-miR-182-5p THBS1 3.53923166221814 5.07781258121574e-21 -2.1277814514878 2.63898598170147e-08 MirTarget -0.464276709680251 4.8914160255443e-25 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-182-5p THBS2 3.53923166221814 5.07781258121574e-21 -0.819009338080235 0.127001426128545 MirTarget;miRNATAP -0.378179542663928 4.95986922868172e-09 NA NA NA hsa-miR-182-5p THSD4 3.53923166221814 5.07781258121574e-21 -2.37339687749734 3.92006931404185e-13 mirMAP -0.235937697536687 6.00156640627385e-09 NA NA NA hsa-miR-182-5p TIFAB 3.53923166221814 5.07781258121574e-21 -0.380124172219658 0.461018639505915 mirMAP -0.334006738668731 8.10090185176446e-08 NA NA NA hsa-miR-182-5p TIMP2 3.53923166221814 5.07781258121574e-21 -1.7485334269093 7.3578966378154e-06 mirMAP -0.444158047245332 3.52992744010483e-22 NA NA NA hsa-miR-182-5p TLN1 3.53923166221814 5.07781258121574e-21 -1.45515106009239 3.18740725534339e-16 miRNATAP -0.286157450117998 2.44934212067043e-45 NA NA NA hsa-miR-182-5p TLN2 3.53923166221814 5.07781258121574e-21 -1.13678695432202 2.37164982459728e-06 mirMAP -0.15378766220221 1.7721581252092e-07 NA NA NA hsa-miR-182-5p TMCC3 3.53923166221814 5.07781258121574e-21 -1.35239851980287 4.93606931842352e-05 mirMAP -0.371835305521499 2.27555513424795e-21 NA NA NA hsa-miR-182-5p TMEM108 3.53923166221814 5.07781258121574e-21 -2.78114300571125 1.45650573276381e-06 mirMAP -0.554421072700645 1.13520993786654e-15 NA NA NA hsa-miR-182-5p TMEM150C 3.53923166221814 5.07781258121574e-21 -1.68081227435943 2.1859051388924e-06 MirTarget -0.182640281609837 2.90186439730772e-05 NA NA NA hsa-miR-182-5p TMEM169 3.53923166221814 5.07781258121574e-21 0.212722927647041 0.605338323475114 miRNATAP -0.16170586583927 0.0012840904702696 NA NA NA hsa-miR-182-5p TMEM47 3.53923166221814 5.07781258121574e-21 -1.46523064388337 0.00016547778482874 MirTarget;miRNATAP -0.135358715260602 0.00473071168334015 NA NA NA hsa-miR-182-5p TMOD1 3.53923166221814 5.07781258121574e-21 -2.50806400410317 3.77309071816302e-19 miRNATAP -0.319318365850882 1.15881737281433e-20 NA NA NA hsa-miR-203a-3p TNF 3.12352008343999 9.49391438647189e-07 0.168287325738871 0.711715304997615 miRTarBase -0.111842196318691 0.000983994485349752 NA NA NA hsa-miR-320a TNF 0.438165828017084 0.0390159073347133 0.168287325738871 0.711715304997615 miRanda -0.394855461451853 0.0001481103227567 NA NA NA hsa-miR-361-5p TNF 0.971859117235239 5.30236555707088e-09 0.168287325738871 0.711715304997615 miRanda -0.363396990950332 0.00589234482466197 NA NA NA hsa-miR-429 TNF 4.48815175680773 2.44117492218206e-17 0.168287325738871 0.711715304997615 miRNATAP -0.169293563460319 1.87983425787946e-05 NA NA NA hsa-miR-340-5p TNFRSF10B 0.30282999308409 0.157744789519131 0.0854160195132305 0.697363353003698 miRNAWalker2_validate -0.130618058364656 0.00887614707841885 NA NA NA hsa-miR-361-5p TNFRSF10C 0.971859117235239 5.30236555707088e-09 -0.499439470720603 0.192162849023382 miRanda -0.259516100289945 0.019605241486501 NA NA NA hsa-miR-186-5p TNFRSF10D 1.47445398888668 3.0781726595413e-15 -1.21952127016643 0.000173029902186277 mirMAP -0.17896857256799 0.0307715580575795 NA NA NA hsa-miR-590-5p TNFRSF10D 3.18300989862077 2.06813568597893e-26 -1.21952127016643 0.000173029902186277 miRanda -0.104917038709611 0.0402849542401198 NA NA NA hsa-miR-129-5p TNFSF10 -0.524170159980738 0.222582956006346 0.62151336306871 0.110711377947693 miRanda -0.171605377985452 0.000117006373445903 NA NA NA hsa-miR-139-5p TNFSF10 -1.52606598644743 1.20474151350665e-08 0.62151336306871 0.110711377947693 miRanda -0.245494690697579 0.000392669662957397 NA NA NA hsa-miR-33a-3p TNFSF10 1.72765312072219 1.51784443453521e-07 0.62151336306871 0.110711377947693 mirMAP -0.24294878555277 8.65859088331346e-05 NA NA NA hsa-miR-361-5p TNFSF10 0.971859117235239 5.30236555707088e-09 0.62151336306871 0.110711377947693 miRanda -0.438574912638159 9.76217270913905e-05 NA NA NA hsa-miR-429 TNFSF10 4.48815175680773 2.44117492218206e-17 0.62151336306871 0.110711377947693 miRanda -0.134275255476822 7.66062319152758e-05 NA NA NA hsa-miR-98-5p TNFSF10 1.11154309866014 1.24143909012085e-08 0.62151336306871 0.110711377947693 miRNAWalker2_validate -0.619752540788512 4.22417181054043e-11 NA NA NA hsa-miR-182-5p TNS3 3.53923166221814 5.07781258121574e-21 -0.103104493452801 0.668815191833344 miRNATAP -0.112337177957411 0.000126125264913059 NA NA NA hsa-miR-182-5p TOX 3.53923166221814 5.07781258121574e-21 -2.0322057253246 1.86502526837513e-05 miRNATAP -0.425802778825031 8.13351765474564e-14 NA NA NA hsa-miR-221-3p TP53 0.451556679024397 0.0909808299917811 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.115825211031354 0.0105671893909646 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-222-3p TP53 0.851783756239071 0.00266783568486918 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.116904656132339 0.00589565055970469 NA NA NA hsa-miR-182-5p TP53INP2 3.53923166221814 5.07781258121574e-21 -2.21250190189587 4.52774358230457e-20 MirTarget;miRNATAP -0.156852896630411 2.89825999559286e-07 NA NA NA hsa-miR-324-3p TRADD 2.08739139768981 3.11885987067952e-13 0.654523627495593 9.31374791447117e-05 miRNATAP -0.107791208741327 9.21494516260199e-05 NA NA NA hsa-miR-182-5p TRAF3 3.53923166221814 5.07781258121574e-21 0.232826128499489 0.140409657391156 mirMAP -0.100497619347189 1.29240740702129e-07 NA NA NA hsa-miR-182-5p TRPM6 3.53923166221814 5.07781258121574e-21 -1.93538766679862 2.33828833032142e-05 MirTarget -0.246711416911322 1.10039461998116e-05 NA NA NA hsa-miR-182-5p TSC22D3 3.53923166221814 5.07781258121574e-21 -1.67435472404316 7.07551770315191e-11 miRNAWalker2_validate;miRNATAP -0.305180456415041 1.27222096476782e-23 NA NA NA hsa-miR-182-5p TSHZ2 3.53923166221814 5.07781258121574e-21 -2.36271880423433 2.34708957144416e-08 miRNATAP -0.307119397948138 3.06959313435153e-09 NA NA NA hsa-miR-182-5p TSPAN11 3.53923166221814 5.07781258121574e-21 -2.3587553580542 3.63548653474133e-10 mirMAP -0.347051550841155 3.0270164105964e-14 NA NA NA hsa-miR-182-5p TSPAN9 3.53923166221814 5.07781258121574e-21 -0.281167092062683 0.142613577594003 MirTarget;miRNATAP -0.113599184378751 9.68036166090994e-07 NA NA NA hsa-miR-182-5p TTBK2 3.53923166221814 5.07781258121574e-21 -1.27061033500643 8.20749802166803e-07 mirMAP -0.156139515435276 7.78480301639662e-07 NA NA NA hsa-miR-182-5p UBE2Q2 3.53923166221814 5.07781258121574e-21 -0.786021468971091 2.04263029736963e-07 MirTarget;miRNATAP -0.106219012806502 8.40657784664679e-09 NA NA NA hsa-miR-182-5p UBR1 3.53923166221814 5.07781258121574e-21 -0.870775603837103 1.62515391893457e-09 mirMAP -0.106588800288203 1.56401780308676e-09 NA NA NA hsa-miR-182-5p UNC5C 3.53923166221814 5.07781258121574e-21 -2.85842438529154 7.1455313233325e-10 mirMAP -0.518965750789195 6.37056810524897e-21 NA NA NA hsa-miR-182-5p VAT1L 3.53923166221814 5.07781258121574e-21 -1.21093342860372 0.00422286393153055 miRNATAP -0.310402604378246 1.22648636436394e-09 NA NA NA hsa-miR-182-5p VCL 3.53923166221814 5.07781258121574e-21 -1.42195933102912 9.04222123827734e-13 miRNATAP -0.250719348001465 1.62430154049536e-26 NA NA NA hsa-miR-182-5p VLDLR 3.53923166221814 5.07781258121574e-21 -1.24679016115614 0.000599286809743815 MirTarget;miRNATAP -0.230979138538618 1.70820982113188e-07 NA NA NA hsa-miR-182-5p WDFY4 3.53923166221814 5.07781258121574e-21 -1.52835958077685 0.00208595788951407 mirMAP -0.514293983627951 1.70350378207187e-18 NA NA NA hsa-miR-182-5p WDR44 3.53923166221814 5.07781258121574e-21 -0.618746968114829 0.00104356284659586 MirTarget -0.123024174487468 7.50288605476641e-08 NA NA NA hsa-miR-182-5p WIPF1 3.53923166221814 5.07781258121574e-21 -1.36396473341553 1.25828143739996e-05 MirTarget;miRNATAP -0.413413248840515 1.07298598160211e-30 NA NA NA hsa-miR-182-5p WISP1 3.53923166221814 5.07781258121574e-21 0.794902972527909 0.129006518215286 MirTarget -0.391982518706977 4.66417906589696e-10 NA NA NA hsa-miR-182-5p WWC2 3.53923166221814 5.07781258121574e-21 -0.762253212847515 0.00511431449708885 MirTarget -0.205285174851598 3.80699465538307e-10 NA NA NA hsa-miR-125b-5p XIAP -1.16462950151259 0.000288900271798384 0.0185824727941606 0.900456705596673 miRNAWalker2_validate -0.134609008147354 6.17145452585339e-10 NA NA NA hsa-miR-146b-5p XIAP 1.75587235896724 1.15724631266659e-07 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.100792988978608 1.7835560220266e-06 NA NA NA hsa-miR-195-3p XIAP -0.658653229922836 0.0142127125129199 0.0185824727941606 0.900456705596673 mirMAP -0.109312331752852 5.17755048006399e-05 NA NA NA hsa-miR-26a-2-3p XIAP 0.823520019989974 0.00017092160823769 0.0185824727941606 0.900456705596673 mirMAP -0.103081650553247 0.0016975998669049 NA NA NA hsa-miR-182-5p ZBTB37 3.53923166221814 5.07781258121574e-21 -0.575470462840692 0.0106071831245277 miRNATAP -0.111712971795685 4.68845729148013e-05 NA NA NA hsa-miR-182-5p ZDHHC14 3.53923166221814 5.07781258121574e-21 -0.420877670161361 0.0714978913519264 mirMAP -0.107611556537821 0.000154777438731494 NA NA NA hsa-miR-182-5p ZFP36L1 3.53923166221814 5.07781258121574e-21 -1.16626499852789 2.6177040079409e-09 miRNATAP -0.128368738757413 9.9958410670594e-08 NA NA NA hsa-miR-182-5p ZMAT3 3.53923166221814 5.07781258121574e-21 -0.834456180454181 0.000338643864818007 mirMAP -0.128544205330595 6.09119797515569e-06 NA NA NA hsa-miR-182-5p ZNF280B 3.53923166221814 5.07781258121574e-21 -1.31579833605866 0.00759832510998532 MirTarget -0.214192781613192 0.000383316797123722 NA NA NA hsa-miR-182-5p ZNF532 3.53923166221814 5.07781258121574e-21 -0.642348594400126 0.00482300004408463 miRNATAP -0.175931129090085 1.3493489891048e-10 NA NA NA