miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-128-3p A2M 0.781932174412697 7.18127563212596e-10 -0.305472876269373 0.000473741676045562 miRNAWalker2_validate -0.172957379162381 8.88350865254221e-11 NA NA NA hsa-miR-128-3p ABCA1 0.781932174412697 7.18127563212596e-10 0.0188106659493208 0.834105815897059 MirTarget -0.172220634343062 7.02704340894571e-09 NA NA NA hsa-miR-128-3p ARID3B 0.781932174412697 7.18127563212596e-10 -0.101335452315805 0.0314167337073368 MirTarget -0.114831005798514 5.59605743173772e-12 NA NA NA hsa-miR-128-3p ARRDC4 0.781932174412697 7.18127563212596e-10 -0.192952323848389 0.0153788794036844 MirTarget -0.154158967730492 3.66473761965727e-08 NA NA NA hsa-miR-128-3p B4GALT1 0.781932174412697 7.18127563212596e-10 -0.148734140472387 0.0468591755720273 miRNAWalker2_validate -0.172450422348125 2.42793323942864e-11 NA NA NA hsa-miR-128-3p BMF 0.781932174412697 7.18127563212596e-10 -0.429207608696316 1.2633548549993e-05 MirTarget -0.392051412253568 1.52127072315478e-30 NA NA NA hsa-miR-128-3p BOC 0.781932174412697 7.18127563212596e-10 -0.226333258668565 0.00884745120498795 miRNAWalker2_validate -0.133778965327085 9.35106345587317e-06 NA NA NA hsa-miR-128-3p BRCA2 0.781932174412697 7.18127563212596e-10 -1.02877893656155 1.26446979656698e-17 miRNAWalker2_validate -0.336076287033201 1.77633450390997e-13 NA NA NA hsa-miR-128-3p CASP3 0.781932174412697 7.18127563212596e-10 -0.262751412479426 2.56855295665512e-06 miRNAWalker2_validate -0.154501736884318 6.74484437136043e-18 NA NA NA hsa-miR-128-3p CCL18 0.781932174412697 7.18127563212596e-10 0.250425934530575 0.299252548216492 MirTarget -0.440303994873336 8.06543784249224e-07 NA NA NA hsa-miR-128-3p CD276 0.781932174412697 7.18127563212596e-10 -0.460031392457725 1.14859333750124e-10 MirTarget -0.296123429308353 1.15638881012357e-39 NA NA NA hsa-miR-128-3p CD2AP 0.781932174412697 7.18127563212596e-10 -0.152153730564539 0.00191277088897953 miRNAWalker2_validate -0.120349274077736 1.43258572169649e-13 NA NA NA hsa-miR-128-3p CD300A 0.781932174412697 7.18127563212596e-10 -0.34887080819548 0.000487927637860146 miRNAWalker2_validate -0.27248425791209 6.08323361099639e-14 NA NA NA hsa-miR-128-3p CDCP1 0.781932174412697 7.18127563212596e-10 -0.510024355135388 5.60069380157114e-06 MirTarget -0.313404110193119 4.29399585630361e-14 NA NA NA hsa-miR-128-3p CDKN2A 0.781932174412697 7.18127563212596e-10 -0.0187886573712475 0.903922340142738 MirTarget -0.262360804552711 6.19986805514199e-06 NA NA NA hsa-miR-128-3p CLIC4 0.781932174412697 7.18127563212596e-10 -0.322332981153439 3.5162392712189e-05 MirTarget -0.217534126827234 6.53997867448127e-21 NA NA NA hsa-miR-128-3p CLP1 0.781932174412697 7.18127563212596e-10 -0.183247538078068 5.72415836748927e-07 MirTarget -0.118725623976344 2.269111283138e-24 NA NA NA hsa-miR-128-3p CLPP 0.781932174412697 7.18127563212596e-10 -0.17480976777779 0.000585289694660558 miRNAWalker2_validate;MirTarget -0.170271460261292 4.49953589919485e-31 NA NA NA hsa-miR-128-3p CLSPN 0.781932174412697 7.18127563212596e-10 -1.31472322676674 4.3204324741422e-17 miRNAWalker2_validate -0.163776019206176 0.00690883271335086 NA NA NA hsa-miR-128-3p CMTM6 0.781932174412697 7.18127563212596e-10 -0.329956372867111 1.37961042412983e-08 miRNAWalker2_validate -0.192876763517628 6.8573810845077e-27 NA NA NA hsa-miR-128-3p COL3A1 0.781932174412697 7.18127563212596e-10 -1.43331954235497 3.86186762290792e-13 MirTarget -0.702024384900442 3.39671131569039e-22 NA NA NA hsa-miR-128-3p CREB3L2 0.781932174412697 7.18127563212596e-10 -0.204901565293184 0.00053481313388513 MirTarget -0.1467252499069 8.73135412690502e-15 NA NA NA hsa-miR-128-3p CSF1 0.781932174412697 7.18127563212596e-10 0.12228734321121 0.208378871498958 MirTarget -0.133621533589285 7.63301513989826e-05 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-128-3p CTDSP1 0.781932174412697 7.18127563212596e-10 -0.0536759287654407 0.336713849209263 miRNAWalker2_validate -0.160154915107576 5.13277349567592e-26 NA NA NA hsa-miR-128-3p CTDSP2 0.781932174412697 7.18127563212596e-10 -0.227462268498413 0.000192117594921058 MirTarget -0.128313125429097 2.39449144256573e-14 NA NA NA hsa-miR-128-3p CTSZ 0.781932174412697 7.18127563212596e-10 -0.247526050731704 0.0051223448138878 miRNAWalker2_validate -0.174559565982015 1.45270418796609e-08 NA NA NA hsa-miR-128-3p CTU1 0.781932174412697 7.18127563212596e-10 -0.100054031188596 0.101043147442939 MirTarget -0.127625643049672 1.11918958818148e-08 NA NA NA hsa-miR-128-3p DOCK11 0.781932174412697 7.18127563212596e-10 -0.343622342572501 1.60024785156059e-06 MirTarget -0.175922755060106 3.35868627500054e-12 NA NA NA hsa-miR-128-3p DOT1L 0.781932174412697 7.18127563212596e-10 -0.202194801055887 0.00986576414664023 MirTarget -0.204498439005301 8.31333503954344e-15 NA NA NA hsa-miR-128-3p E2F7 0.781932174412697 7.18127563212596e-10 -1.46591745821464 2.03279508197687e-19 miRNAWalker2_validate -0.475172886133755 1.52940774969718e-14 NA NA NA hsa-miR-128-3p ECE1 0.781932174412697 7.18127563212596e-10 -0.450211149900418 4.13477673318488e-10 MirTarget -0.16766861512191 2.48339163210144e-12 NA NA NA hsa-miR-128-3p EFEMP2 0.781932174412697 7.18127563212596e-10 -0.470281480881463 7.09108499295272e-05 miRNAWalker2_validate -0.143958626380754 0.00100987783008482 NA NA NA hsa-miR-128-3p EGFR 0.781932174412697 7.18127563212596e-10 -0.375473556369595 0.0155485714375792 miRNAWalker2_validate;miRTarBase -0.123238476195056 0.0295408149966435 NA NA NA hsa-miR-128-3p ERCC1 0.781932174412697 7.18127563212596e-10 -0.146784199864717 0.00612768129892482 MirTarget -0.11917298515768 6.33912592967258e-14 NA NA NA hsa-miR-128-3p ESCO2 0.781932174412697 7.18127563212596e-10 -1.34050561956116 1.56643419137989e-18 miRNAWalker2_validate -0.405300826762471 3.28567023421454e-12 NA NA NA hsa-miR-128-3p FAM126A 0.781932174412697 7.18127563212596e-10 -0.571150145993935 6.38268938614387e-15 MirTarget -0.188741793827577 1.05376113404515e-12 NA NA NA hsa-miR-128-3p FKBP10 0.781932174412697 7.18127563212596e-10 -0.54716364154154 8.86597912596735e-09 miRNAWalker2_validate -0.298353254152238 4.08965279450842e-19 NA NA NA hsa-miR-128-3p G6PC3 0.781932174412697 7.18127563212596e-10 -0.1370517476345 0.00609220452978225 miRNAWalker2_validate -0.120817700025751 7.09239642225303e-20 NA NA NA hsa-miR-128-3p GAPT 0.781932174412697 7.18127563212596e-10 -0.590176419217598 0.000236476987429025 MirTarget -0.377270022450415 2.52259703234599e-10 NA NA NA hsa-miR-128-3p GATA6 0.781932174412697 7.18127563212596e-10 -0.692397066651972 7.14775947725082e-05 miRNAWalker2_validate;MirTarget -0.24932586673797 0.000139400642850532 NA NA NA hsa-miR-128-3p GCC1 0.781932174412697 7.18127563212596e-10 -0.095976502775601 0.024697933555536 MirTarget -0.100481233969534 2.59952355296095e-17 NA NA NA hsa-miR-128-3p GFPT2 0.781932174412697 7.18127563212596e-10 0.126376103912192 0.275121326694085 miRNAWalker2_validate -0.107603457172183 0.00957246449497143 NA NA NA hsa-miR-128-3p GLTSCR2 0.781932174412697 7.18127563212596e-10 0.0529417571135014 0.483142859968869 miRNAWalker2_validate -0.124893939132662 6.35080966394281e-08 NA NA NA hsa-miR-128-3p GYS1 0.781932174412697 7.18127563212596e-10 -0.163492435845412 0.00180552833388565 MirTarget -0.129040041760107 6.10761375299609e-18 NA NA NA hsa-miR-128-3p HIC1 0.781932174412697 7.18127563212596e-10 -0.287135333653437 0.00052318943803611 MirTarget -0.219702669243767 5.46486312732932e-13 NA NA NA hsa-miR-128-3p HMOX1 0.781932174412697 7.18127563212596e-10 -0.44408891638879 1.64054927696364e-05 miRNAWalker2_validate -0.359848050574708 1.11163498775904e-23 NA NA NA hsa-miR-128-3p HOXC6 0.781932174412697 7.18127563212596e-10 -1.49356378608735 4.7565764368537e-11 miRNAWalker2_validate -0.696081675106596 1.01507174966323e-16 NA NA NA hsa-miR-128-3p IL13RA1 0.781932174412697 7.18127563212596e-10 -0.233331210934831 0.0115821447985218 MirTarget -0.14997916924187 3.55162975265756e-06 NA NA NA hsa-miR-128-3p JAG1 0.781932174412697 7.18127563212596e-10 -0.587520818551872 2.624067182555e-12 MirTarget -0.28884114848186 4.23791345007622e-24 NA NA NA hsa-miR-128-3p KCTD14 0.781932174412697 7.18127563212596e-10 -0.290139867222891 0.000586923802865837 miRNAWalker2_validate -0.128739102555995 4.72964659603117e-05 NA NA NA hsa-miR-128-3p KLHDC8A 0.781932174412697 7.18127563212596e-10 -0.654904443005962 3.77849075406215e-08 MirTarget -0.269565344149718 9.37566327685961e-10 NA NA NA hsa-miR-128-3p LBR 0.781932174412697 7.18127563212596e-10 -0.221741723474953 5.40025892816413e-05 miRNAWalker2_validate -0.163243568280034 7.98430058759536e-23 NA NA NA hsa-miR-128-3p LILRB5 0.781932174412697 7.18127563212596e-10 0.479828537458948 0.00172794402658093 miRNAWalker2_validate -0.170504298744315 0.00309991009137081 NA NA NA hsa-miR-128-3p LMNB1 0.781932174412697 7.18127563212596e-10 -0.795248309402114 2.3310776384155e-16 miRNAWalker2_validate -0.312857670111597 4.66816973401474e-19 NA NA NA hsa-miR-128-3p LRAT 0.781932174412697 7.18127563212596e-10 -0.180803048952127 0.289684435746302 MirTarget -0.166781928935745 0.0091862599337793 NA NA NA hsa-miR-128-3p LRRN4CL 0.781932174412697 7.18127563212596e-10 -1.12956245167079 9.19679383894806e-12 MirTarget -0.451109967156151 4.13209415244225e-13 NA NA NA hsa-miR-128-3p LTBP1 0.781932174412697 7.18127563212596e-10 -0.173293782627743 0.109813198572629 MirTarget -0.148199022087748 0.000196858193450294 NA NA NA hsa-miR-128-3p MAP3K8 0.781932174412697 7.18127563212596e-10 -0.158077179723323 0.056374788751712 MirTarget -0.135826037453442 9.23336794439461e-06 NA NA NA hsa-miR-128-3p MAPKAPK3 0.781932174412697 7.18127563212596e-10 -0.066640882226328 0.280567270992401 MirTarget -0.131034188481023 8.75519753669743e-11 NA NA NA hsa-miR-128-3p NEK2 0.781932174412697 7.18127563212596e-10 -1.47415887953635 1.37547484313167e-19 miRNAWalker2_validate;MirTarget -0.291038675943389 3.88599898125693e-06 24046120 In particular we examined miR-128 expression which is thought to target NEK2; We measured NEK2 mRNA and miR-128 levels in clinical samples by quantitative reverse transcription real-time PCR and analyzed the associations between NEK2 levels miR-128 levels clinicopathological factors and prognoses; MiR-128 inhibited NEK2 expression and cancer cell proliferation via cell cycle arrest; Patients with high miR-128 expression had significantly lower NEK2 expression and lower recurrence rates than those with low miR-128 expression; NEK2 may be an independent prognostic factor for CRC and was regulated by miR-128 a microRNA that was subjected to epigenetic regulation recurrence colorectal cancer hsa-miR-128-3p NFIL3 0.781932174412697 7.18127563212596e-10 -0.394457238105468 1.07800090825854e-09 MirTarget -0.170263841495967 2.13534895060962e-14 NA NA NA hsa-miR-128-3p NOP2 0.781932174412697 7.18127563212596e-10 -0.21821709802297 2.27939322269597e-05 miRNAWalker2_validate -0.173190276369644 3.68828549537484e-29 NA NA NA hsa-miR-128-3p NXT1 0.781932174412697 7.18127563212596e-10 -0.328542823573405 7.4843916621267e-10 miRNAWalker2_validate -0.250950426007463 6.03910408802153e-48 NA NA NA hsa-miR-128-3p PDIA5 0.781932174412697 7.18127563212596e-10 -0.576400387176969 7.81292466590725e-09 MirTarget -0.368603419783935 1.2911772391713e-24 NA NA NA hsa-miR-128-3p PDPN 0.781932174412697 7.18127563212596e-10 -1.00574945169594 1.60350453569877e-07 MirTarget -0.473874311909155 3.72592564935938e-11 NA NA NA hsa-miR-128-3p PHB 0.781932174412697 7.18127563212596e-10 -0.102947544867158 0.0409915576715129 MirTarget -0.103782609180092 3.75512245949417e-17 NA NA NA hsa-miR-128-3p PHC2 0.781932174412697 7.18127563212596e-10 -0.213316336196491 0.000599763032457734 MirTarget -0.154763693249672 2.13642250438313e-20 NA NA NA hsa-miR-128-3p PPP4C 0.781932174412697 7.18127563212596e-10 -0.210805680569568 5.16274263040419e-05 MirTarget -0.204441210400649 2.14282192329524e-46 NA NA NA hsa-miR-128-3p PQLC3 0.781932174412697 7.18127563212596e-10 -0.238728384082075 7.1247432164243e-05 MirTarget -0.166825155426431 2.70502925190242e-14 NA NA NA hsa-miR-128-3p PRKD1 0.781932174412697 7.18127563212596e-10 0.0225210494106518 0.692199432788483 MirTarget -0.122940330001218 8.54142632745608e-12 NA NA NA hsa-miR-128-3p PRR11 0.781932174412697 7.18127563212596e-10 -0.704853965885329 1.4579007898907e-07 miRNAWalker2_validate -0.108847614357909 0.0325615580026801 NA NA NA hsa-miR-128-3p RAB20 0.781932174412697 7.18127563212596e-10 -0.0513029832044753 0.561312023294895 MirTarget -0.229526318034695 4.36176305079404e-13 NA NA NA hsa-miR-128-3p RAB34 0.781932174412697 7.18127563212596e-10 -0.589423465992035 4.2598671689988e-07 MirTarget -0.150579715514441 0.000605489124338499 NA NA NA hsa-miR-128-3p RAP1B 0.781932174412697 7.18127563212596e-10 -0.142944911590131 0.00328482194864843 MirTarget -0.147230046784345 1.53070842148117e-27 25017996 miR 128 and miR 149 enhance the chemosensitivity of temozolomide by Rap1B mediated cytoskeletal remodeling in glioblastoma glioblastoma hsa-miR-128-3p RDX 0.781932174412697 7.18127563212596e-10 -0.0913593952133702 0.161534679626132 MirTarget -0.118386008977629 5.16871742708473e-11 NA NA NA hsa-miR-128-3p RPL28 0.781932174412697 7.18127563212596e-10 -0.0825320409894719 0.27539097254953 miRNAWalker2_validate -0.146553537790157 1.3195042857992e-11 NA NA NA hsa-miR-128-3p SAMD9L 0.781932174412697 7.18127563212596e-10 -0.471690135325048 1.06105446245868e-05 MirTarget -0.245652113939805 4.16509612244578e-10 NA NA NA hsa-miR-128-3p SEC61A1 0.781932174412697 7.18127563212596e-10 -0.266453861975053 5.82926997417209e-06 miRNAWalker2_validate;MirTarget -0.17722559874105 2.40655553574338e-40 NA NA NA hsa-miR-128-3p SFXN2 0.781932174412697 7.18127563212596e-10 0.0923428738969552 0.157961107039023 miRNAWalker2_validate -0.123651452599504 2.11236578143653e-07 NA NA NA hsa-miR-128-3p SKA3 0.781932174412697 7.18127563212596e-10 -1.23520280629921 7.97535398215424e-20 MirTarget -0.376991325761166 3.001755346432e-13 NA NA NA hsa-miR-128-3p SLC16A1 0.781932174412697 7.18127563212596e-10 -0.317322960099586 1.6853271016327e-06 miRNAWalker2_validate -0.153354828559388 7.53767535924261e-15 NA NA NA hsa-miR-128-3p SLC39A7 0.781932174412697 7.18127563212596e-10 -0.169341877341379 0.000576647839051983 miRNAWalker2_validate;MirTarget -0.130034104161686 1.01272109724921e-29 NA NA NA hsa-miR-128-3p SOX11 0.781932174412697 7.18127563212596e-10 -0.269962225683294 0.0274165085032646 miRNAWalker2_validate -0.182795583715805 3.4533401481079e-05 NA NA NA hsa-miR-128-3p SOX2 0.781932174412697 7.18127563212596e-10 -0.0616987319734541 0.499752069762618 miRNAWalker2_validate -0.130951669676141 2.49471920283624e-06 NA NA NA hsa-miR-128-3p SPG21 0.781932174412697 7.18127563212596e-10 -0.0648690116979589 0.167515238506094 MirTarget -0.116259480050388 1.58673043278654e-25 NA NA NA hsa-miR-128-3p SSFA2 0.781932174412697 7.18127563212596e-10 -0.300570374608411 1.96597158351727e-06 miRNAWalker2_validate -0.112621205807649 4.31486991869466e-09 NA NA NA hsa-miR-128-3p STEAP3 0.781932174412697 7.18127563212596e-10 -0.85150545110027 5.28142587331439e-10 MirTarget -0.37490843499386 2.7467323425801e-13 NA NA NA hsa-miR-128-3p STK3 0.781932174412697 7.18127563212596e-10 -0.162626811287558 0.0032906000502596 miRNAWalker2_validate;MirTarget -0.199733128312276 4.34671505953338e-27 NA NA NA hsa-miR-128-3p STK40 0.781932174412697 7.18127563212596e-10 -0.425259479771283 5.47212717835944e-10 MirTarget -0.209327063770511 1.24669185873028e-20 NA NA NA hsa-miR-128-3p SUMF1 0.781932174412697 7.18127563212596e-10 -0.188967458307767 0.000342535246833224 miRNAWalker2_validate -0.120448899976317 1.30329258007387e-11 NA NA NA hsa-miR-128-3p TAGLN 0.781932174412697 7.18127563212596e-10 -0.283423008662758 0.00367224168165688 miRNAWalker2_validate -0.179392424200451 1.84112983988039e-07 NA NA NA hsa-miR-128-3p TGFBR1 0.781932174412697 7.18127563212596e-10 -0.339248208669638 4.04767020935411e-07 miRNAWalker2_validate;miRTarBase -0.210164447590872 1.78152956429912e-22 NA NA NA hsa-miR-128-3p TIA1 0.781932174412697 7.18127563212596e-10 -0.0181692412339762 0.773500392636888 MirTarget -0.103871373003611 2.17582232868734e-07 NA NA NA hsa-miR-128-3p TM4SF1 0.781932174412697 7.18127563212596e-10 -0.731287498884869 1.19989249400304e-10 miRNAWalker2_validate -0.261362103313803 3.54959375616426e-10 NA NA NA hsa-miR-128-3p TMEM64 0.781932174412697 7.18127563212596e-10 -0.160692033609724 0.00347401433408365 MirTarget -0.116748859490368 2.41686555193147e-10 NA NA NA hsa-miR-128-3p TMX1 0.781932174412697 7.18127563212596e-10 -0.164842811447974 0.00337398173355225 MirTarget -0.173883230065039 2.36341975747007e-27 NA NA NA hsa-miR-128-3p TNFAIP8 0.781932174412697 7.18127563212596e-10 -0.771372431654312 1.70086464834287e-13 MirTarget -0.414236988403635 2.19537789847727e-27 NA NA NA hsa-miR-128-3p TROVE2 0.781932174412697 7.18127563212596e-10 -0.0779165655884038 0.094669465335578 miRNAWalker2_validate -0.117897138168094 4.66769783752306e-28 NA NA NA hsa-miR-128-3p TSPAN6 0.781932174412697 7.18127563212596e-10 -0.135245003643748 0.0373902004024003 miRNAWalker2_validate -0.19464709940513 3.2543239308088e-21 NA NA NA hsa-miR-128-3p TXNDC5 0.781932174412697 7.18127563212596e-10 -0.354332697675411 2.41086631475108e-11 MirTarget -0.150512349753195 3.73735423807492e-23 NA NA NA hsa-miR-128-3p TXNIP 0.781932174412697 7.18127563212596e-10 0.00762634231189629 0.92254930130747 miRNAWalker2_validate;MirTarget -0.122239039687077 2.16583339080004e-07 NA NA NA hsa-miR-128-3p UTP15 0.781932174412697 7.18127563212596e-10 -0.22372809927145 1.93241672032936e-08 MirTarget -0.126656305062721 2.42563311490768e-22 NA NA NA hsa-miR-128-3p VANGL2 0.781932174412697 7.18127563212596e-10 0.0359057493022616 0.605188496685676 MirTarget -0.115710974894351 3.22374281445121e-08 NA NA NA hsa-miR-128-3p VSIG10 0.781932174412697 7.18127563212596e-10 -0.0627107783069363 0.241196814697871 MirTarget -0.11770608120424 2.3210867058069e-11 NA NA NA hsa-miR-128-3p WEE1 0.781932174412697 7.18127563212596e-10 -0.98569897499735 4.14674818907476e-22 miRNAWalker2_validate;miRTarBase;MirTarget -0.413332363369616 1.06644345449199e-28 NA NA NA hsa-miR-128-3p ZNF552 0.781932174412697 7.18127563212596e-10 -0.216121213132767 1.09232725119595e-06 miRNAWalker2_validate -0.140228407693708 2.39137735315621e-18 NA NA NA