miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p AKT3 -0.203919267842652 0.802213958426804 0.457269233600447 0.539326812115034 miRNATAP -0.549479065869633 4.88994896864722e-11 NA NA NA hsa-miR-106b-5p AKT3 -0.297128724729339 0.869294443540749 0.457269233600447 0.539326812115034 miRNATAP -0.910251258276316 1.51432008761514e-23 NA NA NA hsa-miR-107 AKT3 -0.0365118169251648 0.988364120226869 0.457269233600447 0.539326812115034 PITA;miRanda -0.551086378595188 0.000172037624489873 NA NA NA hsa-miR-1275 AKT3 -0.831342050607648 0.0803795852164229 0.457269233600447 0.539326812115034 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-142-3p AKT3 -0.154235241441331 0.946098054588918 0.457269233600447 0.539326812115034 miRanda -0.196043223886578 0.00627089530211866 NA NA NA hsa-miR-15a-5p AKT3 -0.0674049094129128 0.964835434214123 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.721206491484116 7.61586942839311e-13 NA NA NA hsa-miR-15b-5p AKT3 -0.272614787130877 0.87096541832188 0.457269233600447 0.539326812115034 miRNATAP -0.665977383717092 1.97063059627596e-12 NA NA NA hsa-miR-16-5p AKT3 0.0135949734723564 0.994476223855607 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.746124766270904 9.10401236853758e-16 NA NA NA hsa-miR-17-3p AKT3 0.100221625453134 0.960113387014848 0.457269233600447 0.539326812115034 miRNATAP -0.519758313376015 2.03997342351785e-09 NA NA NA hsa-miR-17-5p AKT3 -0.175448849583061 0.934544015912731 0.457269233600447 0.539326812115034 TargetScan;miRNATAP -0.626536048377156 1.11076874125702e-18 NA NA NA hsa-miR-181b-5p AKT3 0.155313039554487 0.930176779696506 0.457269233600447 0.539326812115034 miRNATAP -0.268064668813324 0.00963449049657038 NA NA NA hsa-miR-20a-5p AKT3 -0.179153323927949 0.928118119139752 0.457269233600447 0.539326812115034 miRNATAP -0.531063551395964 1.32783278364081e-13 NA NA NA hsa-miR-28-3p AKT3 -0.227916837431808 0.935350995840384 0.457269233600447 0.539326812115034 miRNATAP -0.521845591393563 0.00718630427898147 NA NA NA hsa-miR-29a-3p AKT3 0.01127474410284 0.996977020481272 0.457269233600447 0.539326812115034 miRNATAP -0.812359982380835 1.03842433672581e-13 NA NA NA hsa-miR-29b-3p AKT3 -0.104016192263954 0.958988036765397 0.457269233600447 0.539326812115034 miRNATAP -0.677276652111253 9.58518141369729e-17 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 -0.568003960723004 0.13133163420273 0.457269233600447 0.539326812115034 mirMAP -0.563455040593992 1.29815959529041e-22 NA NA NA hsa-miR-320a AKT3 -0.416546433767628 0.840202138616422 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.333446337886203 0.00137735387479576 NA NA NA hsa-miR-320b AKT3 -0.23561798088153 0.859222532827992 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.247020375326149 0.00854841822062789 NA NA NA hsa-miR-335-3p AKT3 -0.244830745789445 0.88450019116631 0.457269233600447 0.539326812115034 mirMAP -0.579661626156677 1.71660731221086e-14 NA NA NA hsa-miR-33a-3p AKT3 -0.794543849238581 0.0105203072007922 0.457269233600447 0.539326812115034 mirMAP -0.48908545949649 5.69174183767199e-12 NA NA NA hsa-miR-340-5p AKT3 -0.00276909425328853 0.99757361161055 0.457269233600447 0.539326812115034 mirMAP -0.282303409119482 0.00600476945925659 NA NA NA hsa-miR-362-3p AKT3 -0.721040238345347 0.0345881362485733 0.457269233600447 0.539326812115034 miRanda -0.415414242264488 1.82625494243827e-09 NA NA NA hsa-miR-362-5p AKT3 -0.26647467080141 0.752024885130738 0.457269233600447 0.539326812115034 PITA;TargetScan;miRNATAP -0.516617267683569 4.2053666241316e-16 NA NA NA hsa-miR-369-3p AKT3 0.116576891957687 0.83230082995912 0.457269233600447 0.539326812115034 mirMAP -0.2347933374382 0.00901179401751285 NA NA NA hsa-miR-374a-5p AKT3 -0.343007247142618 0.766921280269271 0.457269233600447 0.539326812115034 mirMAP -0.579942468779622 2.643062323348e-06 NA NA NA hsa-miR-374b-5p AKT3 -0.285682091626878 0.83569830479965 0.457269233600447 0.539326812115034 mirMAP -0.684416910019692 6.98155817205318e-09 NA NA NA hsa-miR-421 AKT3 -0.182032017078616 0.734704500318599 0.457269233600447 0.539326812115034 miRanda;mirMAP -0.463766741666901 1.36843495165118e-08 NA NA NA hsa-miR-424-5p AKT3 0.247080963500746 0.870154571783568 0.457269233600447 0.539326812115034 miRNATAP -0.239499066096292 0.00104453067376223 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 -0.753812576327832 0.552763280802254 0.457269233600447 0.539326812115034 miRNATAP -0.497935902986368 2.06014814106823e-10 NA NA NA hsa-miR-502-3p AKT3 -0.481234445251923 0.514301076452422 0.457269233600447 0.539326812115034 miRNATAP -0.644160673294049 1.58962279838432e-12 NA NA NA hsa-miR-502-5p AKT3 -0.708507838520586 0.0261309781860104 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.409328372897747 4.31887851181114e-09 NA NA NA hsa-miR-505-3p AKT3 -0.469094267152605 0.690382680489578 0.457269233600447 0.539326812115034 mirMAP -0.774927841273818 6.77311058531751e-15 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548o-3p AKT3 -0.191447572716994 0.517725546183501 0.457269233600447 0.539326812115034 mirMAP -0.314174287829114 7.58105126731538e-05 NA NA NA hsa-miR-577 AKT3 -1.06238199218774 0.326056761787754 0.457269233600447 0.539326812115034 mirMAP -0.383091519653111 6.42065724452006e-20 NA NA NA hsa-miR-663b AKT3 0.101100389887233 0.814989939749933 0.457269233600447 0.539326812115034 PITA -0.247711064601903 1.07528758067609e-05 NA NA NA hsa-miR-769-5p AKT3 -0.306614906942583 0.735704301598833 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.8409977584726 1.11686042031466e-14 NA NA NA hsa-miR-93-5p AKT3 -0.611073677204699 0.825297877093193 0.457269233600447 0.539326812115034 miRNATAP -0.762020096686085 6.75211862260925e-18 NA NA NA hsa-miR-708-3p APAF1 0.137785606206693 0.896980471394499 -0.173549826698829 0.88665142839701 mirMAP -0.105643259572274 0.00109765096412761 NA NA NA hsa-miR-324-5p ATM -0.50063248413014 0.537416710557032 0.191778405096067 0.864625288192543 miRanda -0.12216548800381 0.00154765973160933 NA NA NA hsa-miR-455-5p ATM -0.139599153671262 0.865744220236311 0.191778405096067 0.864625288192543 miRanda -0.119520466419818 0.00128133661552861 NA NA NA hsa-miR-590-5p ATM -0.547819833829572 0.472735645776647 0.191778405096067 0.864625288192543 mirMAP -0.103121093611562 0.00141721793607095 NA NA NA hsa-miR-17-5p BCL2 -0.175448849583061 0.934544015912731 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.313088312531828 1.57403483137732e-05 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-192-5p BCL2 -0.117345487848223 0.972927287653137 -0.871666186967121 0.244961397784127 miRNAWalker2_validate -0.227903685596688 0.000564938952369163 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 -0.0840912027031901 0.972112413910242 -0.871666186967121 0.244961397784127 miRNAWalker2_validate -0.126443433292796 0.00925777817775241 NA NA NA hsa-miR-20a-3p BCL2 0.456808229166028 0.57674056136504 -0.871666186967121 0.244961397784127 mirMAP -0.189828863199929 0.00114914427656055 NA NA NA hsa-miR-20a-5p BCL2 -0.179153323927949 0.928118119139752 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.252117244065233 0.000458303345864534 NA NA NA hsa-miR-224-3p BCL2 0.110372723153393 0.749091467231007 -0.871666186967121 0.244961397784127 mirMAP -0.178399757407561 0.00774691671641716 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-224-5p BCL2 -0.240425158977724 0.857351098476517 -0.871666186967121 0.244961397784127 mirMAP -0.301573774179688 5.62748011416914e-07 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 -0.0947200031589666 0.920155111594601 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.410993226860356 0.00011884046804375 NA NA NA hsa-miR-29a-3p BCL2 0.01127474410284 0.996977020481272 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.340900217647213 0.00193580882132839 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29a-5p BCL2 -0.31835175571979 0.600442757817281 -0.871666186967121 0.244961397784127 mirMAP -0.343932614708693 5.20598038228022e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 -0.104016192263954 0.958988036765397 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase -0.269579801072406 0.00119448246860227 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 -0.244830745789445 0.88450019116631 -0.871666186967121 0.244961397784127 mirMAP -0.24751331586752 0.0011768675011956 NA NA NA hsa-miR-33a-5p BCL2 -0.205788753603336 0.853314500865147 -0.871666186967121 0.244961397784127 mirMAP -0.128574385145016 0.00455510277772182 NA NA NA hsa-miR-450b-5p BCL2 -0.0136687538973108 0.983149761399849 -0.871666186967121 0.244961397784127 mirMAP -0.240978719259764 0.00585784315473669 NA NA NA hsa-miR-452-5p BCL2 -0.0504626418153507 0.973874641360401 -0.871666186967121 0.244961397784127 mirMAP -0.275409981212347 0.000609740122960845 NA NA NA hsa-miR-7-5p BCL2 0.209645143210379 0.773705612298441 -0.871666186967121 0.244961397784127 miRNAWalker2_validate;miRTarBase;mirMAP -0.195234863896821 0.000177663908838853 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7a-5p BCL2L1 -0.0620211756550422 0.985006886285188 0.242557541702429 0.890959530804569 TargetScan;miRNATAP -0.267237022843277 0.00149660612153832 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-miR-126-5p BIRC2 0.0815213541035824 0.956637332055185 -0.0106795252457266 0.993398701750218 mirMAP -0.118457212505085 0.000726831525567633 NA NA NA hsa-miR-24-1-5p BIRC3 -0.185440327527663 0.791525781516963 -0.141537792183018 0.897243027958393 MirTarget -0.308965184090704 0.00144701353789959 NA NA NA hsa-miR-651-5p BIRC3 -0.571699708815578 0.172535889612301 -0.141537792183018 0.897243027958393 MirTarget -0.162521309985949 0.00706165901458035 NA NA NA hsa-miR-20a-3p CAPN2 0.456808229166028 0.57674056136504 0.0419450866249376 0.981485804916366 MirTarget -0.108106917803323 0.00146092490218196 NA NA NA hsa-miR-421 CAPN2 -0.182032017078616 0.734704500318599 0.0419450866249376 0.981485804916366 miRanda -0.251742166674529 3.20703831647803e-08 NA NA NA hsa-miR-7-5p CAPN2 0.209645143210379 0.773705612298441 0.0419450866249376 0.981485804916366 miRNAWalker2_validate -0.117773166189262 9.87489283744295e-05 NA NA NA hsa-miR-181c-5p CASP10 0.042951891660695 0.969159991881861 -0.286859095851538 0.807133415486649 mirMAP -0.15340907917641 0.00318018728342029 NA NA NA hsa-miR-30a-5p CASP3 0.219472325612346 0.933954023293816 -0.162965782047655 0.903158908366085 miRNATAP -0.203229832372977 5.73122351633379e-05 NA NA NA hsa-miR-143-3p CASP8 0.371591944134735 0.927341352649583 -0.268951646645792 0.828588317117104 MirTarget -0.109420620201972 0.000545823380266859 NA NA NA hsa-miR-130b-3p CFLAR -0.221667315324818 0.824660172394714 -0.0613591175648374 0.961399997619075 mirMAP -0.173341915965256 4.40375106449909e-08 NA NA NA hsa-miR-374b-5p CFLAR -0.285682091626878 0.83569830479965 -0.0613591175648374 0.961399997619075 MirTarget -0.155358286185632 0.000353399655735518 NA NA NA hsa-miR-421 CFLAR -0.182032017078616 0.734704500318599 -0.0613591175648374 0.961399997619075 miRanda -0.113191277664472 0.000158299555763676 NA NA NA hsa-miR-23b-3p CHUK -0.10822254818704 0.961352920317636 -0.096549775668116 0.93218060129343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.136584882734319 0.00997084019729046 NA NA NA hsa-miR-15b-3p CSF2RB -0.557749208157585 0.609181305423188 -0.424243791231997 0.608009754706655 mirMAP -0.556320542920735 1.69990147768674e-07 NA NA NA hsa-miR-186-5p CSF2RB -0.318786974828757 0.85412722938961 -0.424243791231997 0.608009754706655 mirMAP -0.525426499153246 0.000371798037133893 NA NA NA hsa-miR-19a-3p CSF2RB -0.206793507801887 0.844637784802316 -0.424243791231997 0.608009754706655 MirTarget -0.505159885757328 3.13732608161195e-09 NA NA NA hsa-miR-19b-3p CSF2RB -0.0268530183621474 0.986656783046572 -0.424243791231997 0.608009754706655 MirTarget -0.674202290730517 2.38029074307712e-11 NA NA NA hsa-miR-30b-3p CSF2RB -0.514644352757504 0.162424853398397 -0.424243791231997 0.608009754706655 MirTarget -0.432501376695226 2.00030751491199e-05 NA NA NA hsa-miR-452-3p CSF2RB -0.167134177977311 0.799008246175244 -0.424243791231997 0.608009754706655 mirMAP -0.426783979867021 4.47079759509159e-09 NA NA NA hsa-miR-532-5p CSF2RB -0.349665553500088 0.878948352437467 -0.424243791231997 0.608009754706655 MirTarget -0.370796066761641 0.000414661072596092 NA NA NA hsa-miR-576-5p CSF2RB -0.506413219377403 0.417187951364173 -0.424243791231997 0.608009754706655 miRNATAP -0.357189326802445 0.000704779079248235 NA NA NA hsa-miR-590-3p CSF2RB -0.279244755376859 0.59126669933662 -0.424243791231997 0.608009754706655 miRanda;mirMAP -0.393241297046802 6.12226396413448e-06 NA NA NA hsa-miR-625-5p CSF2RB -0.690759472145277 0.210306534567564 -0.424243791231997 0.608009754706655 MirTarget -0.28968042535212 0.000169238256842656 NA NA NA hsa-miR-139-5p CYCS -0.0810891026597322 0.928690377743652 -0.0801546909855499 0.965739955684414 miRanda -0.180455845650641 6.81104021035486e-05 NA NA NA hsa-miR-34c-3p CYCS -0.0677097368202059 0.825448151326958 -0.0801546909855499 0.965739955684414 mirMAP -0.100294994424538 0.00799698860616829 NA NA NA hsa-miR-34c-5p CYCS -0.018707656771723 0.952788306178575 -0.0801546909855499 0.965739955684414 miRanda -0.158065264009806 0.000330182557876286 NA NA NA hsa-miR-26a-5p DFFA 0.00698202897993028 0.997719986197021 -0.286184108412671 0.79394722058605 mirMAP -0.168274500452959 0.0068437272660124 NA NA NA hsa-miR-30a-3p DFFA 0.250338313897394 0.917094926793447 -0.286184108412671 0.79394722058605 mirMAP -0.15330990955248 0.000342001437069929 NA NA NA hsa-miR-34c-5p DFFA -0.018707656771723 0.952788306178575 -0.286184108412671 0.79394722058605 miRanda -0.107013929351907 0.000766413071466021 NA NA NA hsa-miR-664a-3p DFFA -0.00395670341813714 0.996119749372707 -0.286184108412671 0.79394722058605 mirMAP -0.14037347665929 0.000427317567574411 NA NA NA hsa-miR-19a-3p ENDOD1 -0.206793507801887 0.844637784802316 0.0425516652586362 0.973765218340755 mirMAP -0.122963065450002 0.00066314640646562 NA NA NA hsa-miR-19b-3p ENDOD1 -0.0268530183621474 0.986656783046572 0.0425516652586362 0.973765218340755 mirMAP -0.165048640654556 0.000126182776117063 NA NA NA hsa-miR-20a-3p ENDOD1 0.456808229166028 0.57674056136504 0.0425516652586362 0.973765218340755 MirTarget -0.10361772928502 0.000629639913459516 NA NA NA hsa-miR-335-3p ENDOD1 -0.244830745789445 0.88450019116631 0.0425516652586362 0.973765218340755 MirTarget -0.111195490010087 0.00518202798660825 NA NA NA hsa-miR-450b-5p ENDOD1 -0.0136687538973108 0.983149761399849 0.0425516652586362 0.973765218340755 MirTarget;mirMAP -0.120468654825167 0.00808480426752155 NA NA NA hsa-miR-454-3p ENDOD1 -0.101514866328011 0.843545158256191 0.0425516652586362 0.973765218340755 MirTarget -0.153376783661297 0.00321362308379351 NA NA NA hsa-miR-106a-5p FAS -0.203919267842652 0.802213958426804 -0.347166376396346 0.702810017457386 miRNAWalker2_validate;miRTarBase -0.309397365527179 1.69760652678533e-06 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-361-5p FAS -0.138735309928775 0.941495130308343 -0.347166376396346 0.702810017457386 miRanda -0.421714311791871 0.000155426639121472 NA NA NA hsa-miR-590-5p FAS -0.547819833829572 0.472735645776647 -0.347166376396346 0.702810017457386 miRanda -0.168205409634763 0.00402598857592482 NA NA NA hsa-miR-98-5p FAS -0.168162186023221 0.898802461503524 -0.347166376396346 0.702810017457386 miRNAWalker2_validate -0.378145247947084 2.09454221266366e-05 NA NA NA hsa-miR-452-3p FASLG -0.167134177977311 0.799008246175244 -1.01623663960814 0.0497518030689545 mirMAP -0.300498727144317 0.000506966650214745 NA NA NA hsa-miR-92a-3p FASLG 0.0278830870766349 0.993247426671713 -1.01623663960814 0.0497518030689545 miRNATAP -0.376276337966714 0.00278748481239554 NA NA NA hsa-miR-130b-5p IL1R1 -0.6472141103776 0.379096015222509 0.0971978498625941 0.931380268505521 mirMAP -0.597849986911064 5.11784999134223e-16 NA NA NA hsa-miR-17-3p IL1R1 0.100221625453134 0.960113387014848 0.0971978498625941 0.931380268505521 mirMAP -0.54511908545044 5.99236041868129e-12 NA NA NA hsa-miR-186-5p IL1R1 -0.318786974828757 0.85412722938961 0.0971978498625941 0.931380268505521 mirMAP -0.76373595274815 2.23069407996303e-12 NA NA NA hsa-miR-192-5p IL1R1 -0.117345487848223 0.972927287653137 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.521064610824822 2.08223348177442e-18 NA NA NA hsa-miR-197-3p IL1R1 -0.455489147957159 0.794916582095149 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.449558594621509 1.86929045400014e-07 NA NA NA hsa-miR-215-5p IL1R1 -0.142648109361913 0.94480931294964 0.0971978498625941 0.931380268505521 miRNAWalker2_validate -0.126995092092766 0.00191347086429665 NA NA NA hsa-miR-24-3p IL1R1 -0.0484778924256624 0.985274054814493 0.0971978498625941 0.931380268505521 miRNATAP -0.603457361426173 0.000199088441297218 NA NA NA hsa-miR-26b-5p IL1R1 -0.0245931278499594 0.990377966314923 0.0971978498625941 0.931380268505521 mirMAP -0.726194062963501 2.40186470051492e-12 NA NA NA hsa-miR-30d-3p IL1R1 -0.123474741320298 0.814905367625791 0.0971978498625941 0.931380268505521 mirMAP -0.633771957362426 1.5127976345712e-13 NA NA NA hsa-miR-335-3p IL1R1 -0.244830745789445 0.88450019116631 0.0971978498625941 0.931380268505521 mirMAP -0.54040951986299 1.03169031216036e-14 NA NA NA hsa-miR-361-5p IL1R1 -0.138735309928775 0.941495130308343 0.0971978498625941 0.931380268505521 miRanda -0.657872921900768 1.10573544927298e-06 NA NA NA hsa-miR-491-5p IL1R1 -0.585652105321328 0.0452620602586908 0.0971978498625941 0.931380268505521 miRanda -0.217319722631291 0.00269495220336367 NA NA NA hsa-miR-548o-3p IL1R1 -0.191447572716994 0.517725546183501 0.0971978498625941 0.931380268505521 mirMAP -0.315827960543417 1.61184818710973e-05 NA NA NA hsa-miR-590-3p IL1R1 -0.279244755376859 0.59126669933662 0.0971978498625941 0.931380268505521 miRanda;miRNATAP -0.491268245890511 1.60582758504113e-14 NA NA NA hsa-let-7f-2-3p IL1RAP -0.0455032713433074 0.882115725419367 0.160675392694305 0.831548529623142 MirTarget -0.143957447514746 0.000223258886839442 NA NA NA hsa-miR-106a-5p IL1RAP -0.203919267842652 0.802213958426804 0.160675392694305 0.831548529623142 MirTarget -0.191209658239253 1.85074870272663e-05 NA NA NA hsa-miR-106b-5p IL1RAP -0.297128724729339 0.869294443540749 0.160675392694305 0.831548529623142 MirTarget -0.22683139900241 1.12618261166573e-05 NA NA NA hsa-miR-130a-3p IL1RAP 0.0910074087716906 0.929098200371948 0.160675392694305 0.831548529623142 MirTarget -0.181371247466266 0.000103811850845334 NA NA NA hsa-miR-130b-3p IL1RAP -0.221667315324818 0.824660172394714 0.160675392694305 0.831548529623142 MirTarget -0.221022135841534 1.66111023280578e-06 NA NA NA hsa-miR-140-5p IL1RAP -0.229213026275906 0.847330111738616 0.160675392694305 0.831548529623142 miRanda -0.219834909432766 0.000958228682157065 NA NA NA hsa-miR-17-5p IL1RAP -0.175448849583061 0.934544015912731 0.160675392694305 0.831548529623142 MirTarget;TargetScan -0.167083380776715 2.24340063359446e-05 NA NA NA hsa-miR-186-5p IL1RAP -0.318786974828757 0.85412722938961 0.160675392694305 0.831548529623142 mirMAP -0.215436006186164 0.000723436159590429 NA NA NA hsa-miR-192-5p IL1RAP -0.117345487848223 0.972927287653137 0.160675392694305 0.831548529623142 miRNAWalker2_validate -0.130876760847657 0.000261025518657414 NA NA NA hsa-miR-19a-3p IL1RAP -0.206793507801887 0.844637784802316 0.160675392694305 0.831548529623142 MirTarget -0.169817189194384 5.47943782915461e-06 NA NA NA hsa-miR-19b-3p IL1RAP -0.0268530183621474 0.986656783046572 0.160675392694305 0.831548529623142 MirTarget -0.169145163821916 0.000171747903012152 NA NA NA hsa-miR-20a-5p IL1RAP -0.179153323927949 0.928118119139752 0.160675392694305 0.831548529623142 MirTarget -0.135143648023773 0.000546968419998277 NA NA NA hsa-miR-224-3p IL1RAP 0.110372723153393 0.749091467231007 0.160675392694305 0.831548529623142 MirTarget -0.111832100082262 0.00205907823590406 NA NA NA hsa-miR-29a-3p IL1RAP 0.01127474410284 0.996977020481272 0.160675392694305 0.831548529623142 MirTarget;miRNATAP -0.189900879878914 0.00146794004616984 NA NA NA hsa-miR-29b-3p IL1RAP -0.104016192263954 0.958988036765397 0.160675392694305 0.831548529623142 MirTarget;miRNATAP -0.207537091842477 3.31119368573026e-06 NA NA NA hsa-miR-301a-3p IL1RAP -0.105312511901769 0.831686745977347 0.160675392694305 0.831548529623142 MirTarget -0.110801422785086 0.00515676532544119 NA NA NA hsa-miR-335-3p IL1RAP -0.244830745789445 0.88450019116631 0.160675392694305 0.831548529623142 mirMAP -0.126935389314144 0.00221953478927472 NA NA NA hsa-miR-339-5p IL1RAP -0.300425087100667 0.712912847076788 0.160675392694305 0.831548529623142 miRanda -0.157548289284125 1.95582183274076e-05 NA NA NA hsa-miR-362-3p IL1RAP -0.721040238345347 0.0345881362485733 0.160675392694305 0.831548529623142 miRanda -0.122157232448564 0.000940585501855135 NA NA NA hsa-miR-421 IL1RAP -0.182032017078616 0.734704500318599 0.160675392694305 0.831548529623142 MirTarget;miRanda -0.14393848910528 0.000929642182093677 NA NA NA hsa-miR-454-3p IL1RAP -0.101514866328011 0.843545158256191 0.160675392694305 0.831548529623142 MirTarget -0.174325214931229 0.0013240928608515 NA NA NA hsa-miR-576-5p IL1RAP -0.506413219377403 0.417187951364173 0.160675392694305 0.831548529623142 mirMAP -0.17059562065834 0.000166778354203674 NA NA NA hsa-miR-590-3p IL1RAP -0.279244755376859 0.59126669933662 0.160675392694305 0.831548529623142 MirTarget;miRanda;mirMAP -0.137014180275726 0.000289189242093682 NA NA NA hsa-miR-590-5p IL1RAP -0.547819833829572 0.472735645776647 0.160675392694305 0.831548529623142 miRanda -0.206981550022239 1.40879946161304e-07 NA NA NA hsa-miR-7-1-3p IL1RAP -0.462485777435991 0.665899751398166 0.160675392694305 0.831548529623142 MirTarget -0.119783168396852 0.00722481327087485 NA NA NA hsa-miR-93-5p IL1RAP -0.611073677204699 0.825297877093193 0.160675392694305 0.831548529623142 MirTarget -0.148566202859431 0.00262519781442786 NA NA NA hsa-miR-95-3p IL1RAP -0.0818004840634243 0.924053102559599 0.160675392694305 0.831548529623142 MirTarget -0.107032389017763 0.00158073977211462 NA NA NA hsa-miR-362-3p IL3RA -0.721040238345347 0.0345881362485733 0.163928312094029 0.804758258942851 miRanda -0.169156809721412 0.00190481779053269 NA NA NA hsa-miR-330-5p IRAK1 -0.283418953659271 0.815687101334695 0.084323356691633 0.963335362026959 miRNAWalker2_validate -0.197496743914743 0.000137818885389644 NA NA NA hsa-miR-141-3p IRAK3 -0.31994058840327 0.87774106909065 0.129331135700148 0.833494953850949 mirMAP -0.465426995904877 3.51591599318979e-10 NA NA NA hsa-miR-148b-5p IRAK3 -0.236618793990305 0.43925706879726 0.129331135700148 0.833494953850949 mirMAP -0.264576206209992 0.00135007642446132 NA NA NA hsa-miR-16-1-3p IRAK3 0.151694812889216 0.733736501874638 0.129331135700148 0.833494953850949 mirMAP -0.259652841527637 0.00108866630766155 NA NA NA hsa-miR-16-2-3p IRAK3 -0.36717860153421 0.546850726070016 0.129331135700148 0.833494953850949 mirMAP -0.366374149356245 7.8385784516044e-06 NA NA NA hsa-miR-16-5p IRAK3 0.0135949734723564 0.994476223855607 0.129331135700148 0.833494953850949 miRNAWalker2_validate -0.397299409262029 8.66739899564317e-05 NA NA NA hsa-miR-186-5p IRAK3 -0.318786974828757 0.85412722938961 0.129331135700148 0.833494953850949 mirMAP -0.413817823283351 0.00109544230842425 NA NA NA hsa-miR-188-5p IRAK3 -0.568517670542551 0.324820848307954 0.129331135700148 0.833494953850949 mirMAP -0.346399236116401 1.18313475327637e-07 NA NA NA hsa-miR-200a-3p IRAK3 -0.367034437440907 0.851059894150266 0.129331135700148 0.833494953850949 mirMAP -0.385739967241973 1.35303542299515e-07 NA NA NA hsa-miR-20a-3p IRAK3 0.456808229166028 0.57674056136504 0.129331135700148 0.833494953850949 mirMAP -0.338637800764729 3.9467090370602e-08 NA NA NA hsa-miR-25-3p IRAK3 -0.457540448732733 0.878574066837636 0.129331135700148 0.833494953850949 mirMAP -0.538542703139969 1.88617082799896e-05 NA NA NA hsa-miR-32-5p IRAK3 -0.05993267619119 0.952975951594959 0.129331135700148 0.833494953850949 mirMAP -0.417640631571904 1.57549496387142e-06 NA NA NA hsa-miR-320a IRAK3 -0.416546433767628 0.840202138616422 0.129331135700148 0.833494953850949 miRanda -0.325022057848163 0.00255822915515794 NA NA NA hsa-miR-324-5p IRAK3 -0.50063248413014 0.537416710557032 0.129331135700148 0.833494953850949 miRanda -0.43679993953373 3.31909975599297e-06 NA NA NA hsa-miR-335-3p IRAK3 -0.244830745789445 0.88450019116631 0.129331135700148 0.833494953850949 mirMAP -0.409653481443299 4.18935271469258e-07 NA NA NA hsa-miR-33a-5p IRAK3 -0.205788753603336 0.853314500865147 0.129331135700148 0.833494953850949 mirMAP -0.23947658972329 6.06023958751047e-07 NA NA NA hsa-miR-33b-5p IRAK3 -0.161971614375297 0.737436207821109 0.129331135700148 0.833494953850949 mirMAP -0.245120333016334 4.46760457245626e-06 NA NA NA hsa-miR-374b-5p IRAK3 -0.285682091626878 0.83569830479965 0.129331135700148 0.833494953850949 mirMAP -0.463327217900918 0.000204263226960193 NA NA NA hsa-miR-421 IRAK3 -0.182032017078616 0.734704500318599 0.129331135700148 0.833494953850949 miRanda;mirMAP -0.3616958188324 2.45003123007711e-05 NA NA NA hsa-miR-429 IRAK3 -0.456485631615963 0.806240953400535 0.129331135700148 0.833494953850949 miRanda -0.425758585732957 7.64398672844813e-10 NA NA NA hsa-miR-452-3p IRAK3 -0.167134177977311 0.799008246175244 0.129331135700148 0.833494953850949 mirMAP -0.32921253822962 1.59813580677593e-07 NA NA NA hsa-miR-501-5p IRAK3 -0.834032628506285 0.0582725160418523 0.129331135700148 0.833494953850949 mirMAP -0.240553834358301 0.000323581506933706 NA NA NA hsa-miR-505-3p IRAK3 -0.469094267152605 0.690382680489578 0.129331135700148 0.833494953850949 mirMAP -0.472467317865043 1.11943278345456e-05 NA NA NA hsa-miR-577 IRAK3 -1.06238199218774 0.326056761787754 0.129331135700148 0.833494953850949 mirMAP -0.270286536956 3.18755843416807e-09 NA NA NA hsa-miR-589-3p IRAK3 -0.835836305204965 0.0112001563801511 0.129331135700148 0.833494953850949 mirMAP -0.238744109082446 0.000657563114442049 NA NA NA hsa-miR-590-3p IRAK3 -0.279244755376859 0.59126669933662 0.129331135700148 0.833494953850949 miRanda;mirMAP -0.352883933624394 2.05342611467168e-06 NA NA NA hsa-miR-590-5p IRAK3 -0.547819833829572 0.472735645776647 0.129331135700148 0.833494953850949 mirMAP -0.49643899767587 1.09709493119848e-10 NA NA NA hsa-miR-660-5p IRAK3 -0.476129334484339 0.694082832658925 0.129331135700148 0.833494953850949 mirMAP -0.421351949576795 4.33625288903982e-06 NA NA NA hsa-miR-7-1-3p IRAK3 -0.462485777435991 0.665899751398166 0.129331135700148 0.833494953850949 mirMAP -0.297057942845784 0.000756660155946671 NA NA NA hsa-miR-92a-3p IRAK3 0.0278830870766349 0.993247426671713 0.129331135700148 0.833494953850949 mirMAP -0.493472769653974 5.73878060234433e-08 NA NA NA hsa-miR-320b IRAK4 -0.23561798088153 0.859222532827992 0.265455844077453 0.801341521138687 miRanda -0.107386784856994 0.000783409013485639 NA NA NA hsa-miR-335-5p NFKBIA -0.0284895175847679 0.973380867832231 0.077065001931901 0.957680876120832 miRNAWalker2_validate -0.13105129059451 0.000423884835448271 NA NA NA hsa-let-7f-1-3p PIK3CA -0.31101436822914 0.693407210545374 0.0225357621933919 0.979422693316883 mirMAP -0.118501081655342 0.0064771514178073 NA NA NA hsa-miR-148a-5p PIK3CA -0.448099743845604 0.748419139652266 0.0225357621933919 0.979422693316883 mirMAP -0.112357517651492 7.06215647986463e-05 NA NA NA hsa-miR-148b-3p PIK3CA -0.202106692287125 0.911884960581838 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.117892096365902 0.00490902202717801 NA NA NA hsa-miR-16-2-3p PIK3CA -0.36717860153421 0.546850726070016 0.0225357621933919 0.979422693316883 mirMAP -0.10245614796563 9.13897985797286e-05 NA NA NA hsa-miR-17-5p PIK3CA -0.175448849583061 0.934544015912731 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.115705723770344 3.03228335548689e-06 NA NA NA hsa-miR-186-5p PIK3CA -0.318786974828757 0.85412722938961 0.0225357621933919 0.979422693316883 mirMAP -0.146329134056921 0.000268937701971312 NA NA NA hsa-miR-32-3p PIK3CA -0.568003960723004 0.13133163420273 0.0225357621933919 0.979422693316883 mirMAP -0.112972746252127 2.51225612643757e-08 NA NA NA hsa-miR-335-5p PIK3CA -0.0284895175847679 0.973380867832231 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.10180509768488 9.82755134026126e-05 NA NA NA hsa-miR-339-5p PIK3CA -0.300425087100667 0.712912847076788 0.0225357621933919 0.979422693316883 miRanda -0.103587269763801 8.44655068921029e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.285682091626878 0.83569830479965 0.0225357621933919 0.979422693316883 mirMAP -0.142766383581644 0.00032150800529493 NA NA NA hsa-miR-501-5p PIK3CA -0.834032628506285 0.0582725160418523 0.0225357621933919 0.979422693316883 mirMAP -0.110757579310586 1.16330645525834e-07 NA NA NA hsa-miR-576-5p PIK3CA -0.506413219377403 0.417187951364173 0.0225357621933919 0.979422693316883 PITA -0.113974010997229 6.59094941020168e-05 NA NA NA hsa-miR-582-3p PIK3CA -0.2334649592375 0.897678119160318 0.0225357621933919 0.979422693316883 miRNATAP -0.140113361530972 2.23178585157338e-06 NA NA NA hsa-miR-590-3p PIK3CA -0.279244755376859 0.59126669933662 0.0225357621933919 0.979422693316883 miRanda;mirMAP -0.123897140594567 1.31301452772078e-07 NA NA NA hsa-miR-590-5p PIK3CA -0.547819833829572 0.472735645776647 0.0225357621933919 0.979422693316883 miRanda -0.140125048782077 1.41706046141534e-08 NA NA NA hsa-miR-96-5p PIK3CA 0.0854810872029343 0.923087820185031 0.0225357621933919 0.979422693316883 TargetScan -0.128475980855667 9.81905908048452e-08 NA NA NA hsa-miR-1468-5p PIK3CD -0.200868572236891 0.688408103178562 -0.0499659666229988 0.947033498136668 MirTarget -0.293090508926218 0.000248785469894942 NA NA NA hsa-miR-29a-3p PIK3CD 0.01127474410284 0.996977020481272 -0.0499659666229988 0.947033498136668 mirMAP -0.351166771873915 0.00243536234086878 NA NA NA hsa-miR-29b-3p PIK3CD -0.104016192263954 0.958988036765397 -0.0499659666229988 0.947033498136668 mirMAP -0.263613715224296 0.00266331795083224 NA NA NA hsa-miR-30b-5p PIK3CD -0.0121430518253582 0.994622896704513 -0.0499659666229988 0.947033498136668 MirTarget -0.395682674717868 3.65190942130723e-06 NA NA NA hsa-miR-30c-5p PIK3CD -0.298383882401475 0.865809030482001 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.419452305097446 0.000712699686404817 NA NA NA hsa-miR-30d-5p PIK3CD -0.168211838771867 0.95173197030375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.360885227262785 0.00123008895505406 NA NA NA hsa-miR-421 PIK3CD -0.182032017078616 0.734704500318599 -0.0499659666229988 0.947033498136668 miRanda -0.48895286723391 2.44692621373687e-09 NA NA NA hsa-miR-484 PIK3CD -0.179977202691249 0.886333755572375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.351057480112147 0.00143452196121959 NA NA NA hsa-miR-7-5p PIK3CD 0.209645143210379 0.773705612298441 -0.0499659666229988 0.947033498136668 miRTarBase;MirTarget;miRNATAP -0.196228010352377 0.000352590199023202 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-942-5p PIK3CD -0.50502396741886 0.50777904281306 -0.0499659666229988 0.947033498136668 MirTarget -0.192312219113083 0.0086308226579878 NA NA NA hsa-miR-126-3p PIK3CG -0.106293136341574 0.963670566555251 -0.358088978987777 0.469718116584845 miRTarBase -0.534372493039168 0.000484031176443627 NA NA NA hsa-miR-26b-5p PIK3CG -0.0245931278499594 0.990377966314923 -0.358088978987777 0.469718116584845 miRNAWalker2_validate -0.795245028298382 7.45064172731532e-07 NA NA NA hsa-miR-29b-3p PIK3CG -0.104016192263954 0.958988036765397 -0.358088978987777 0.469718116584845 miRTarBase -0.666133284835925 1.9528746633095e-08 NA NA NA hsa-miR-335-3p PIK3CG -0.244830745789445 0.88450019116631 -0.358088978987777 0.469718116584845 mirMAP -0.563949149516835 2.51672261116185e-07 NA NA NA hsa-miR-421 PIK3CG -0.182032017078616 0.734704500318599 -0.358088978987777 0.469718116584845 miRanda -0.444524915857051 0.000133233454665448 NA NA NA hsa-miR-502-5p PIK3CG -0.708507838520586 0.0261309781860104 -0.358088978987777 0.469718116584845 miRNATAP -0.340480467784473 0.000652722824953133 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-590-3p PIK3CG -0.279244755376859 0.59126669933662 -0.358088978987777 0.469718116584845 miRanda -0.438492197588501 1.39596666922937e-05 NA NA NA hsa-miR-132-3p PIK3R1 -0.244143673573889 0.871752726220643 -0.107670470040419 0.937523599303491 MirTarget -0.191363026291576 0.00729852053203983 NA NA NA hsa-miR-15a-5p PIK3R1 -0.0674049094129128 0.964835434214123 -0.107670470040419 0.937523599303491 MirTarget -0.217108462406312 8.91731617861317e-05 NA NA NA hsa-miR-15b-5p PIK3R1 -0.272614787130877 0.87096541832188 -0.107670470040419 0.937523599303491 MirTarget -0.14300320532504 0.00643583854060318 NA NA NA hsa-miR-16-5p PIK3R1 0.0135949734723564 0.994476223855607 -0.107670470040419 0.937523599303491 MirTarget -0.189731088951203 0.0002621971143127 NA NA NA hsa-miR-185-5p PIK3R1 -0.294432218239008 0.820591478398594 -0.107670470040419 0.937523599303491 miRNATAP -0.23627908813405 0.00027005032337405 NA NA NA hsa-miR-21-5p PIK3R1 -0.148920887107433 0.970240620972126 -0.107670470040419 0.937523599303491 miRNAWalker2_validate;MirTarget;miRNATAP -0.32048586087571 3.69693869528844e-05 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.0224067199236484 0.973232008101458 -0.107670470040419 0.937523599303491 MirTarget -0.229364822725893 5.39528810633945e-05 NA NA NA hsa-miR-22-5p PIK3R1 -0.0785922550675187 0.93169760098231 -0.107670470040419 0.937523599303491 mirMAP -0.186145388676108 2.66965799007355e-05 NA NA NA hsa-miR-221-3p PIK3R1 0.0906940388127513 0.959121118272534 -0.107670470040419 0.937523599303491 MirTarget -0.197435928682178 0.000527618156345501 NA NA NA hsa-miR-222-3p PIK3R1 -0.0265849318772702 0.984005474689108 -0.107670470040419 0.937523599303491 MirTarget -0.202803725155249 6.41878654683067e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.116576891957687 0.83230082995912 -0.107670470040419 0.937523599303491 PITA -0.167895129809982 0.000380018195201003 NA NA NA hsa-miR-424-5p PIK3R1 0.247080963500746 0.870154571783568 -0.107670470040419 0.937523599303491 MirTarget -0.119382000204097 0.00203768025896863 NA NA NA hsa-miR-450b-5p PIK3R1 -0.0136687538973108 0.983149761399849 -0.107670470040419 0.937523599303491 miRNATAP -0.190787246019265 6.82791616588e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.188168046511374 0.909252939431573 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda -0.150969723974234 0.00748950466389255 NA NA NA hsa-miR-582-5p PIK3R1 -0.399450205475138 0.581227478860085 -0.107670470040419 0.937523599303491 mirMAP -0.142451077115944 0.0045721005781701 NA NA NA hsa-miR-590-3p PIK3R1 -0.279244755376859 0.59126669933662 -0.107670470040419 0.937523599303491 miRanda;mirMAP -0.146401290926594 0.000138874186663878 NA NA NA hsa-miR-590-5p PIK3R1 -0.547819833829572 0.472735645776647 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda;miRNATAP -0.15721405103923 0.000108223764424085 NA NA NA hsa-miR-30a-5p PIK3R2 0.219472325612346 0.933954023293816 -0.297680606771329 0.850152230341952 miRNATAP -0.205862820761505 5.83465711487357e-06 NA NA NA hsa-miR-181c-5p PIK3R3 0.042951891660695 0.969159991881861 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.166375015135553 0.00307339705460455 NA NA NA hsa-miR-181d-5p PIK3R3 0.14926527647499 0.888000971478017 -0.276772749610974 0.793454902449853 MirTarget -0.160008098502222 0.000261018045617695 NA NA NA hsa-miR-19a-3p PIK3R3 -0.206793507801887 0.844637784802316 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.116147528359031 0.00952170048888319 NA NA NA hsa-miR-19b-3p PIK3R3 -0.0268530183621474 0.986656783046572 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.194729521448902 0.000250390771046988 NA NA NA hsa-miR-32-5p PIK3R3 -0.05993267619119 0.952975951594959 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.138065839958076 0.00869251602983598 NA NA NA hsa-miR-335-3p PIK3R3 -0.244830745789445 0.88450019116631 -0.276772749610974 0.793454902449853 mirMAP -0.200911178812086 3.4951167686824e-05 NA NA NA hsa-miR-339-5p PIK3R3 -0.300425087100667 0.712912847076788 -0.276772749610974 0.793454902449853 MirTarget;miRanda -0.114440753951127 0.00949514702310638 NA NA NA hsa-miR-454-3p PIK3R3 -0.101514866328011 0.843545158256191 -0.276772749610974 0.793454902449853 mirMAP -0.183582040707033 0.00426750044797469 NA NA NA hsa-miR-92a-3p PIK3R3 0.0278830870766349 0.993247426671713 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.264671393069774 1.12229021521678e-06 NA NA NA hsa-miR-182-5p PIK3R5 -0.104238497940557 0.973380614062243 -0.266913830275555 0.638823741545427 MirTarget -0.335738588315792 0.000137422868989864 NA NA NA hsa-miR-18a-3p PIK3R5 -0.270443061178857 0.535291623032886 -0.266913830275555 0.638823741545427 MirTarget -0.247792416366587 0.000674544930154222 NA NA NA hsa-miR-17-5p PPP3CA -0.175448849583061 0.934544015912731 -0.087509752034574 0.946989676888573 miRNATAP -0.109137738299345 0.000214467204408686 NA NA NA hsa-miR-29a-5p PPP3CA -0.31835175571979 0.600442757817281 -0.087509752034574 0.946989676888573 mirMAP;miRNATAP -0.110664225522305 0.000326600214856183 NA NA NA hsa-miR-335-3p PPP3CA -0.244830745789445 0.88450019116631 -0.087509752034574 0.946989676888573 MirTarget -0.158993670541163 1.48991898684692e-07 NA NA NA hsa-miR-361-5p PPP3CA -0.138735309928775 0.941495130308343 -0.087509752034574 0.946989676888573 miRanda -0.181593940934707 0.00153602268336464 NA NA NA hsa-miR-374b-3p PPP3CA -0.0542885924440247 0.860753623992354 -0.087509752034574 0.946989676888573 MirTarget -0.118414724128426 0.00147351846810998 NA NA NA hsa-miR-361-5p PPP3CB -0.138735309928775 0.941495130308343 0.124829671662728 0.918408096293941 miRanda -0.192230575391786 6.63676765547426e-06 NA NA NA hsa-miR-421 PPP3CB -0.182032017078616 0.734704500318599 0.124829671662728 0.918408096293941 miRanda -0.101890409493066 2.52334802788457e-05 NA NA NA hsa-miR-375 PPP3CC -0.690952835064582 0.831716365337668 -0.156394846840244 0.838706340015868 miRanda -0.115145516987059 0.000311412501063658 NA NA NA hsa-miR-500a-3p PPP3CC -0.633375813338735 0.732582832733155 -0.156394846840244 0.838706340015868 MirTarget;miRNATAP -0.139392380696939 0.00623176129399307 NA NA NA hsa-miR-143-5p PPP3R1 0.10589969923845 0.933358732923556 -0.0496199114529308 0.972488514207793 miRNATAP -0.101757134766809 6.67106697655597e-08 NA NA NA hsa-miR-27b-3p PPP3R1 -0.14277121795778 0.951937409841932 -0.0496199114529308 0.972488514207793 miRNATAP -0.108860558741904 0.00403865953676784 NA NA NA hsa-miR-126-5p PRKACB 0.0815213541035824 0.956637332055185 0.143826955266481 0.908097519021419 mirMAP -0.368751851213397 0.00120348231579359 NA NA NA hsa-miR-146b-5p PRKACB -0.402662509440887 0.837510937985091 0.143826955266481 0.908097519021419 miRanda -0.384839282045274 0.000123624033577825 NA NA NA hsa-miR-16-2-3p PRKACB -0.36717860153421 0.546850726070016 0.143826955266481 0.908097519021419 mirMAP -0.327254668787011 5.02396526650647e-05 NA NA NA hsa-miR-18a-5p PRKACB -0.498318455303917 0.61264091975585 0.143826955266481 0.908097519021419 miRNATAP -0.245987058818593 0.000136929122339416 NA NA NA hsa-miR-18b-5p PRKACB -0.0473300652227538 0.899981261531446 0.143826955266481 0.908097519021419 miRNATAP -0.219595347623136 0.000526621294339559 NA NA NA hsa-miR-19a-3p PRKACB -0.206793507801887 0.844637784802316 0.143826955266481 0.908097519021419 MirTarget;miRNATAP -0.207051001728292 0.00506627328237604 NA NA NA hsa-miR-32-3p PRKACB -0.568003960723004 0.13133163420273 0.143826955266481 0.908097519021419 mirMAP;miRNATAP -0.203540155235648 0.00148647674126439 NA NA NA hsa-miR-577 PRKACB -1.06238199218774 0.326056761787754 0.143826955266481 0.908097519021419 PITA -0.156719343600752 0.000649809465517546 NA NA NA hsa-miR-582-5p PRKACB -0.399450205475138 0.581227478860085 0.143826955266481 0.908097519021419 MirTarget;PITA;miRNATAP -0.435642871850008 4.26493780643228e-06 NA NA NA hsa-miR-590-3p PRKACB -0.279244755376859 0.59126669933662 0.143826955266481 0.908097519021419 MirTarget;PITA;miRanda;miRNATAP -0.287824756359109 8.97202997356946e-05 NA NA NA hsa-miR-590-5p PRKACB -0.547819833829572 0.472735645776647 0.143826955266481 0.908097519021419 miRanda -0.269757804036837 0.000543621862271192 NA NA NA hsa-miR-7-1-3p PRKACB -0.462485777435991 0.665899751398166 0.143826955266481 0.908097519021419 mirMAP -0.347600791347028 5.3123112509601e-05 NA NA NA hsa-miR-141-3p PRKAR1A -0.31994058840327 0.87774106909065 0.00609526627430945 0.997181041723674 TargetScan -0.111566385407566 1.13475156521372e-05 NA NA NA hsa-miR-186-5p PRKAR1A -0.318786974828757 0.85412722938961 0.00609526627430945 0.997181041723674 mirMAP -0.138960379056428 0.00106445683378931 NA NA NA hsa-miR-192-5p PRKAR1A -0.117345487848223 0.972927287653137 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.131803218144219 1.70399939775818e-08 NA NA NA hsa-miR-25-3p PRKAR1A -0.457540448732733 0.878574066837636 0.00609526627430945 0.997181041723674 miRNAWalker2_validate -0.155774990597685 0.000238887566163613 NA NA NA hsa-miR-30b-5p PRKAR1A -0.0121430518253582 0.994622896704513 0.00609526627430945 0.997181041723674 mirMAP -0.112381249090017 0.000145079830949191 NA NA NA hsa-miR-30c-5p PRKAR1A -0.298383882401475 0.865809030482001 0.00609526627430945 0.997181041723674 mirMAP -0.148458841630206 0.000480668595228994 NA NA NA hsa-miR-30e-5p PRKAR1A -0.0657075181381011 0.979684509181941 0.00609526627430945 0.997181041723674 mirMAP -0.144338082514963 0.00222023007638473 NA NA NA hsa-miR-429 PRKAR1A -0.456485631615963 0.806240953400535 0.00609526627430945 0.997181041723674 PITA;miRanda;miRNATAP -0.112635018707528 1.77370772834144e-06 NA NA NA hsa-miR-590-5p PRKAR1A -0.547819833829572 0.472735645776647 0.00609526627430945 0.997181041723674 miRanda -0.144344848438657 3.15475815244105e-08 NA NA NA hsa-miR-96-5p PRKAR1A 0.0854810872029343 0.923087820185031 0.00609526627430945 0.997181041723674 miRNAWalker2_validate;TargetScan;miRNATAP -0.107845623125508 2.75117721818048e-05 NA NA NA hsa-miR-92b-3p PRKAR1B -0.569866984318692 0.689321861489779 0.0318450328183282 0.977136177336556 miRNATAP -0.161354834160575 0.000403900793748172 NA NA NA hsa-miR-140-5p PRKAR2A -0.229213026275906 0.847330111738616 -0.400359254658287 0.684081395451204 miRanda -0.262253655591601 0.000785119044577268 NA NA NA hsa-miR-142-5p PRKAR2A -0.118920788314118 0.929665277963083 -0.400359254658287 0.684081395451204 mirMAP -0.131302359195398 0.00643039296671213 NA NA NA hsa-miR-16-5p PRKAR2A 0.0135949734723564 0.994476223855607 -0.400359254658287 0.684081395451204 miRNAWalker2_validate -0.161229698537964 0.00754804821283647 NA NA NA hsa-miR-26b-5p PRKAR2A -0.0245931278499594 0.990377966314923 -0.400359254658287 0.684081395451204 mirMAP -0.243606301117074 0.000622312559360522 NA NA NA hsa-miR-377-3p PRKAR2A -0.0435868040110954 0.893514136702459 -0.400359254658287 0.684081395451204 mirMAP -0.138724729417275 0.0032774854170653 NA NA NA hsa-miR-92b-3p PRKAR2A -0.569866984318692 0.689321861489779 -0.400359254658287 0.684081395451204 mirMAP -0.150628105250479 0.00333148415222561 NA NA NA hsa-let-7a-3p PRKAR2B -0.215598045625677 0.85543299203799 -0.108203352456923 0.864208239994479 mirMAP -0.321301677507322 0.00677085783389006 NA NA NA hsa-let-7f-1-3p PRKAR2B -0.31101436822914 0.693407210545374 -0.108203352456923 0.864208239994479 mirMAP -0.534962041770848 0.000913984496763097 NA NA NA hsa-miR-186-5p PRKAR2B -0.318786974828757 0.85412722938961 -0.108203352456923 0.864208239994479 mirMAP -0.502782469096194 0.000791078328150689 NA NA NA hsa-miR-200b-3p PRKAR2B -0.426401948379212 0.863957108574195 -0.108203352456923 0.864208239994479 TargetScan -0.438478599626453 2.19850692584662e-05 NA NA NA hsa-miR-200c-3p PRKAR2B -0.437282635857873 0.887118598436407 -0.108203352456923 0.864208239994479 miRNATAP -0.457503221137187 1.66816486062485e-05 NA NA NA hsa-miR-32-5p PRKAR2B -0.05993267619119 0.952975951594959 -0.108203352456923 0.864208239994479 miRNATAP -0.489592612964453 1.9710313510613e-06 NA NA NA hsa-miR-335-3p PRKAR2B -0.244830745789445 0.88450019116631 -0.108203352456923 0.864208239994479 mirMAP -0.662453520071633 1.1362940635392e-12 NA NA NA hsa-miR-361-5p PRKAR2B -0.138735309928775 0.941495130308343 -0.108203352456923 0.864208239994479 miRanda -0.882164157140769 7.23663062288783e-07 NA NA NA hsa-miR-362-3p PRKAR2B -0.721040238345347 0.0345881362485733 -0.108203352456923 0.864208239994479 miRanda -0.382045203466261 8.77748662261711e-06 NA NA NA hsa-miR-429 PRKAR2B -0.456485631615963 0.806240953400535 -0.108203352456923 0.864208239994479 PITA;miRanda;miRNATAP -0.40684001346636 9.90307216676999e-07 NA NA NA hsa-miR-452-5p PRKAR2B -0.0504626418153507 0.973874641360401 -0.108203352456923 0.864208239994479 miRNATAP -0.354765023961755 0.000542795811909376 NA NA NA hsa-miR-590-3p PRKAR2B -0.279244755376859 0.59126669933662 -0.108203352456923 0.864208239994479 miRNAWalker2_validate;miRanda -0.364663794042552 3.74985761919246e-05 NA NA NA hsa-miR-92a-3p PRKAR2B 0.0278830870766349 0.993247426671713 -0.108203352456923 0.864208239994479 miRNATAP -0.706146585820868 2.44308347035194e-11 NA NA NA hsa-miR-339-5p TNF -0.300425087100667 0.712912847076788 -0.242556492684374 0.505877742425651 miRanda -0.240752524581911 0.00150463927692232 NA NA NA hsa-miR-429 TNF -0.456485631615963 0.806240953400535 -0.242556492684374 0.505877742425651 miRNATAP -0.201076512972768 0.00615440839426584 NA NA NA hsa-miR-577 TNF -1.06238199218774 0.326056761787754 -0.242556492684374 0.505877742425651 miRNATAP -0.134551715326189 0.00528975118205988 NA NA NA hsa-miR-30a-5p TNFRSF10B 0.219472325612346 0.933954023293816 -0.383201678231656 0.799628854665791 miRNAWalker2_validate -0.290874641193986 0.000283561036834234 NA NA NA hsa-miR-199b-5p TNFRSF10D -0.0396557270992508 0.977172718873203 -0.141542495826742 0.872377920782891 miRanda -0.224317948876358 0.00104992803157878 NA NA NA hsa-miR-26a-5p TNFRSF10D 0.00698202897993028 0.997719986197021 -0.141542495826742 0.872377920782891 mirMAP -0.415065974648953 0.00259807529206913 NA NA NA hsa-miR-98-5p TNFSF10 -0.168162186023221 0.898802461503524 -0.27351623447675 0.846347198734811 miRNAWalker2_validate -0.161749402252697 0.00700741596734545 NA NA NA hsa-miR-146b-5p XIAP -0.402662509440887 0.837510937985091 0.000689557720739309 0.999627321412725 mirMAP;miRNATAP -0.101204227996522 0.00433301524867694 NA NA NA