miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-28-5p AAGAB -0.14267073663385 0.0497619246260571 0.814198545635563 5.08425148014984e-36 miRanda -0.261414067779177 1.78986406092867e-16 NA NA NA hsa-miR-28-5p AATK -0.14267073663385 0.0497619246260571 0.453430702519743 0.00408123503396711 miRanda -0.27417826152726 0.000266548654540702 NA NA NA hsa-miR-107 ABCA6 0.678998026350662 2.56224148930538e-16 -3.37131627518057 1.64349479129446e-62 miRanda -0.725154315234607 1.52925878610589e-16 NA NA NA hsa-miR-338-3p ABCA6 0.0799903526884966 0.575137668326679 -3.37131627518057 1.64349479129446e-62 miRanda -0.262946307037137 5.08532911524849e-07 NA NA NA hsa-miR-342-3p ABCA6 1.21944481975657 6.81914373001202e-19 -3.37131627518057 1.64349479129446e-62 miRanda -0.296047685530205 2.43317479817588e-08 NA NA NA hsa-miR-590-3p ABCA6 1.27438512890514 1.03164723481469e-23 -3.37131627518057 1.64349479129446e-62 miRanda -0.592278380376161 4.02114653471078e-24 NA NA NA hsa-miR-590-5p ABCA6 0.746515607868274 8.51300479640125e-09 -3.37131627518057 1.64349479129446e-62 miRanda -0.56615378725046 3.90141128100853e-24 NA NA NA hsa-miR-320b ABCA8 0.412787504747938 0.00113457276903985 -5.12296245421974 8.80430177796252e-60 miRanda -0.611767614844479 1.8207070604109e-11 NA NA NA hsa-miR-375 ABCA8 2.09893673049766 1.68351780396203e-16 -5.12296245421974 8.80430177796252e-60 miRanda -0.198990481692328 7.91519287617365e-06 NA NA NA hsa-miR-590-3p ABCA8 1.27438512890514 1.03164723481469e-23 -5.12296245421974 8.80430177796252e-60 miRanda -1.07283831783142 4.3822713793597e-33 NA NA NA hsa-miR-28-5p ABCB9 -0.14267073663385 0.0497619246260571 0.947933279325208 1.1543853299555e-17 miRanda -0.262888980111223 9.28660818341309e-07 NA NA NA hsa-miR-28-5p ABCC5 -0.14267073663385 0.0497619246260571 0.797302989981293 1.93030507748535e-11 miRanda -0.158910926194168 0.00553032764471306 NA NA NA hsa-miR-28-5p ABHD1 -0.14267073663385 0.0497619246260571 -0.979242702067246 7.11422819612358e-10 miRanda -0.304354305354412 6.60803787379825e-05 NA NA NA hsa-miR-28-5p ABLIM3 -0.14267073663385 0.0497619246260571 -1.87900809021962 1.5479100001313e-23 miRanda -0.636062725407327 2.75091626853684e-12 NA NA NA hsa-miR-28-5p ACACA -0.14267073663385 0.0497619246260571 -0.221648651129382 0.021619749795881 miRanda -0.161588815074034 0.00043088920351934 NA NA NA hsa-miR-107 ACACB 0.678998026350662 2.56224148930538e-16 -3.51459082649618 2.24761178914304e-90 miRanda -0.423296993983158 9.92031486868596e-08 NA NA NA hsa-miR-324-5p ACACB 0.211552647440779 0.139408130311654 -3.51459082649618 2.24761178914304e-90 miRanda -0.338640691477732 2.40718635594353e-13 NA NA NA hsa-miR-455-5p ACACB 0.284641224662773 0.0357572339594277 -3.51459082649618 2.24761178914304e-90 miRanda -0.216756460707789 1.11449976672398e-05 NA NA NA hsa-miR-28-5p ACAD8 -0.14267073663385 0.0497619246260571 -0.35954398205226 2.03716487332537e-07 miRanda -0.124555556230843 0.000165960983426681 NA NA NA hsa-miR-375 ACADL 2.09893673049766 1.68351780396203e-16 -5.19429156085254 1.39084260292337e-61 miRanda -0.35573006332611 6.12142933858555e-16 NA NA NA hsa-miR-28-5p ACAT1 -0.14267073663385 0.0497619246260571 -0.751385545284676 2.05460285005042e-17 miRanda -0.156118622908354 0.000274432130308958 NA NA NA hsa-miR-28-5p ACOX3 -0.14267073663385 0.0497619246260571 0.203718310604422 0.0232698998426671 miRanda -0.184836000309236 1.4443916193675e-05 NA NA NA hsa-miR-28-5p ACSF2 -0.14267073663385 0.0497619246260571 -0.25646487247878 0.0548866843292958 miRanda -0.311846743736682 8.46857904574377e-07 NA NA NA hsa-miR-375 ACSL4 2.09893673049766 1.68351780396203e-16 -1.47773903295013 8.01517847091735e-37 miRanda -0.207731595995472 4.60076461290407e-42 NA NA NA hsa-miR-107 ACSM5 0.678998026350662 2.56224148930538e-16 -3.68039448821614 1.59970564359875e-80 miRanda -0.444478915858436 3.4834446399102e-07 NA NA NA hsa-miR-320b ACSM5 0.412787504747938 0.00113457276903985 -3.68039448821614 1.59970564359875e-80 miRanda -0.321452101359222 2.76352406348723e-08 NA NA NA hsa-miR-590-3p ACSM5 1.27438512890514 1.03164723481469e-23 -3.68039448821614 1.59970564359875e-80 miRanda -0.601753195244146 7.02013340195386e-26 NA NA NA hsa-miR-28-5p ADAMTS13 -0.14267073663385 0.0497619246260571 0.49002440332112 0.000583985090350807 miRanda -0.252476874446622 0.000201582106068662 NA NA NA hsa-miR-375 ADAMTS3 2.09893673049766 1.68351780396203e-16 -1.84542990234679 6.7161576251528e-32 miRanda -0.211377302072856 6.27565684140763e-24 NA NA NA hsa-miR-28-5p ADCK1 -0.14267073663385 0.0497619246260571 0.187517081387471 0.00450919989695981 miRanda -0.120939647200665 0.000115520676281999 NA NA NA hsa-miR-28-5p ADCY1 -0.14267073663385 0.0497619246260571 -0.0486801025784516 0.841490665662841 miRanda -0.592080609407235 2.7807221777423e-07 NA NA NA hsa-miR-375 ADCY3 2.09893673049766 1.68351780396203e-16 -0.577026712399736 7.2058708663603e-13 miRanda -0.121210754435367 1.08407257088921e-31 NA NA NA hsa-miR-28-5p ADCY6 -0.14267073663385 0.0497619246260571 -0.631200513666625 6.14065292828624e-14 miRanda -0.322887202501352 6.58653319288642e-16 NA NA NA hsa-miR-342-3p ADH1B 1.21944481975657 6.81914373001202e-19 -7.23318494086375 8.85226630409144e-51 miRanda -0.535735190357566 1.92824076299191e-05 NA NA NA hsa-miR-429 ADH1B 2.84108892259147 3.88520896426515e-64 -7.23318494086375 8.85226630409144e-51 miRanda -1.0781625753393 1.9622994082779e-30 NA NA NA hsa-miR-590-3p ADH1B 1.27438512890514 1.03164723481469e-23 -7.23318494086375 8.85226630409144e-51 miRanda -1.25562930066074 1.15969027753658e-19 NA NA NA hsa-miR-590-3p ADH1C 1.27438512890514 1.03164723481469e-23 -5.25785146917021 2.81381697564496e-59 miRanda -0.926798897428869 3.47889470356009e-23 NA NA NA hsa-miR-320b ADIPOQ 0.412787504747938 0.00113457276903985 -7.20325851283244 9.76136333708247e-50 miRanda -0.719032852182911 2.67098305074773e-07 NA NA NA hsa-miR-330-5p ADIPOQ 0.626063225953928 3.42215028606779e-09 -7.20325851283244 9.76136333708247e-50 miRanda -1.12115324470239 9.59160713229235e-12 NA NA NA hsa-miR-339-5p ADIPOQ -0.211548290465418 0.0685885445822389 -7.20325851283244 9.76136333708247e-50 miRanda -0.326510493016279 0.0330757463237657 NA NA NA hsa-miR-429 ADIPOQ 2.84108892259147 3.88520896426515e-64 -7.20325851283244 9.76136333708247e-50 miRanda -1.05631389311478 7.03943458075418e-29 NA NA NA hsa-miR-590-3p ADIPOQ 1.27438512890514 1.03164723481469e-23 -7.20325851283244 9.76136333708247e-50 miRanda -1.19501846388951 1.05956670430483e-17 NA NA NA hsa-miR-28-5p AFF1 -0.14267073663385 0.0497619246260571 -0.822613403095266 3.54527732954134e-21 miRanda -0.181485420169248 1.84515565349079e-05 NA NA NA hsa-miR-28-5p AFF4 -0.14267073663385 0.0497619246260571 -0.281510843525455 0.00153080576834839 miRanda -0.198317096353644 2.59227723832472e-06 NA NA NA hsa-miR-28-5p AFTPH -0.14267073663385 0.0497619246260571 0.310042514383331 6.63540668673408e-07 miRanda -0.100572748665942 0.000737307674554123 NA NA NA hsa-miR-28-5p AGAP11 -0.14267073663385 0.0497619246260571 -2.71964004520601 8.30765328552898e-62 miRanda -0.311912698282939 0.000215531155380505 NA NA NA hsa-miR-28-5p AGBL4 -0.14267073663385 0.0497619246260571 -0.142971148431008 0.45128658353738 miRanda -0.235687807620684 0.00911628251703385 NA NA NA hsa-miR-155-5p AGTR1 1.09766314984151 4.55650930885814e-15 -2.43890435030112 7.47327507281762e-16 miRTarBase -0.565112011661452 1.06603671182202e-14 22525818 MicroRNA-155 miR-155 is one of the micro RNAs miRNA most consistently involved in neoplastic diseases and it is known to repress the angiotensin II type 1 receptor AGTR1; The aim of the present study was to evaluate the expressions of miR-155 and AGTR1 and to clarify the potential efficacy of anti-miR-155 alone and in combination with AGTR1 blocker losartan in endometrial cancers; Expressions of miR-155 and AGTR1 were evaluated using real-time PCR and immunohistochemistry; miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues; We checked that abolishing the function of miR-155 and AGTR1 by anti-miR-155 or losartan inhibited cell survival of endometrial carcinoma cells respectively and furthermore combined treatment showed synergistic effects; In this study we characterized the expressions of miR-155 and AGTR1 in endometrial tissues; The combined treatment with anti-miR-155 and losartan has a synergistic antiproliferative effect and an improved understanding is required to clarify whether miR-155 and AGTR1 can be used as a novel therapeutic target in endometrial cancer poor survival endometrial cancer hsa-miR-28-5p AHNAK -0.14267073663385 0.0497619246260571 -1.76535987346934 5.20116033627817e-56 miRanda -0.267450672419509 2.68436282191842e-06 NA NA NA hsa-miR-183-5p AKAP12 2.95681814393872 1.09965777344285e-92 -2.7612699271992 1.19711805932247e-64 miRTarBase -0.537020940183852 1.04961055841343e-53 NA NA NA hsa-miR-375 AKAP6 2.09893673049766 1.68351780396203e-16 -2.28015270926059 6.96245937007291e-60 miRanda -0.113850093049129 7.84133703308836e-09 NA NA NA hsa-miR-375 AKAP7 2.09893673049766 1.68351780396203e-16 -1.0178339192539 7.53705785799862e-33 miRanda -0.110996980809323 2.22534687315583e-22 NA NA NA hsa-miR-28-5p AKR7A2 -0.14267073663385 0.0497619246260571 0.343255312465302 8.62257546469888e-06 miRanda -0.23936896990541 5.47058062758386e-11 NA NA NA hsa-miR-15a-5p AKT3 0.812445324157528 4.50263417099822e-20 -1.39153139819913 1.56022353185962e-23 miRTarBase -0.50537113863267 1.94212195956378e-21 NA NA NA hsa-miR-107 ALB 0.678998026350662 2.56224148930538e-16 -3.87147674349154 8.78063322705667e-26 miRanda -0.715478539079117 3.9181832645798e-06 NA NA NA hsa-miR-193a-3p ALB 0.310617999804917 0.00477640270974957 -3.87147674349154 8.78063322705667e-26 miRanda -0.392529613642218 0.000935564055639502 NA NA NA hsa-miR-320b ALB 0.412787504747938 0.00113457276903985 -3.87147674349154 8.78063322705667e-26 miRanda -0.464733518889504 6.40802800188674e-06 NA NA NA hsa-miR-339-5p ALB -0.211548290465418 0.0685885445822389 -3.87147674349154 8.78063322705667e-26 miRanda -0.271430479949259 0.0159882253432693 NA NA NA hsa-miR-590-3p ALB 1.27438512890514 1.03164723481469e-23 -3.87147674349154 8.78063322705667e-26 miRanda -0.735638653580663 1.06620835426113e-12 NA NA NA hsa-miR-107 ALDH1A2 0.678998026350662 2.56224148930538e-16 -3.85370511379791 2.06729750457558e-67 miRanda -0.754617259001971 9.60461000624445e-15 NA NA NA hsa-miR-142-3p ALDH1A2 1.53951237846104 2.06769936282034e-17 -3.85370511379791 2.06729750457558e-67 miRanda -0.235871255886067 1.18939512170225e-07 NA NA NA hsa-miR-330-5p ALDH1A2 0.626063225953928 3.42215028606779e-09 -3.85370511379791 2.06729750457558e-67 miRanda -0.675767590456699 7.85043225744475e-19 NA NA NA hsa-miR-338-3p ALDH1A2 0.0799903526884966 0.575137668326679 -3.85370511379791 2.06729750457558e-67 miRanda -0.226652198149186 9.56006794858023e-05 NA NA NA hsa-miR-28-5p ALDH3A2 -0.14267073663385 0.0497619246260571 -0.860769652123822 9.84587277412076e-16 miRanda -0.292717815903004 1.40563132631418e-08 NA NA NA hsa-miR-146b-5p AMIGO2 0.631041661167954 6.20366593452965e-08 -1.57919489364877 1.03555350832452e-17 miRanda -0.113787497459566 0.0388706773545101 NA NA NA hsa-miR-28-5p AMIGO2 -0.14267073663385 0.0497619246260571 -1.57919489364877 1.03555350832452e-17 miRanda -0.238335214108372 0.00783964240570731 NA NA NA hsa-miR-330-5p AMIGO2 0.626063225953928 3.42215028606779e-09 -1.57919489364877 1.03555350832452e-17 miRanda -0.227912677511026 0.000161521325852071 NA NA NA hsa-miR-361-5p AMIGO2 -0.0996867547900457 0.095428250126326 -1.57919489364877 1.03555350832452e-17 miRanda -0.299427150784499 0.00637054806250741 NA NA NA hsa-miR-28-5p AMPH -0.14267073663385 0.0497619246260571 -0.229137854504136 0.257667598863092 miRanda -0.379789131994063 7.84571508819915e-05 NA NA NA hsa-miR-28-5p AMZ1 -0.14267073663385 0.0497619246260571 2.49247827940287 4.85570356046494e-25 miRanda -0.449900404852048 0.000141115554584685 NA NA NA hsa-miR-28-5p ANGEL1 -0.14267073663385 0.0497619246260571 -0.244973705180581 5.45027775560672e-05 miRanda -0.140734378364615 1.04645383987188e-06 NA NA NA hsa-miR-21-5p ANKRD46 2.32007501846389 3.08394781855554e-137 -0.464275837433727 5.25998680892498e-08 miRTarBase -0.309003306442088 3.15456465435422e-33 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC breast cancer hsa-miR-28-5p ANKS1B -0.14267073663385 0.0497619246260571 0.195574172772792 0.219403504513109 miRanda -0.42370630515817 1.82751876578841e-08 NA NA NA hsa-miR-28-5p ANKS3 -0.14267073663385 0.0497619246260571 0.722561297123601 2.02940894883196e-12 miRanda -0.161675758886296 0.00110175526475344 NA NA NA hsa-miR-375 ANO4 2.09893673049766 1.68351780396203e-16 -1.89180414865337 4.86866295228441e-20 miRanda -0.127318693799825 4.54211271122188e-06 NA NA NA hsa-miR-28-5p ANXA9 -0.14267073663385 0.0497619246260571 1.77703853413407 4.65169713363917e-15 miRanda -1.04785141788144 1.34518763922765e-22 NA NA NA hsa-miR-28-5p AP2A2 -0.14267073663385 0.0497619246260571 0.0276176473817644 0.559431685651471 miRanda -0.117522775082671 1.3499752433353e-07 NA NA NA hsa-miR-28-5p AP2B1 -0.14267073663385 0.0497619246260571 0.256868055359782 0.00182779940285162 miRanda -0.218773775664612 2.05664703731146e-08 NA NA NA hsa-miR-375 APBB1IP 2.09893673049766 1.68351780396203e-16 -1.18647316054575 4.02954740551006e-24 miRanda -0.129151936868526 1.34300033454086e-16 NA NA NA hsa-miR-155-5p APC 1.09766314984151 4.55650930885814e-15 -0.686703117134189 5.76715056853234e-16 miRTarBase -0.154771290746743 4.27853241366662e-14 23796566 Upregulated miR 155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/β catenin signaling; We have searched for miR-155 targets and identified the hypothesis that miR-155 could promote tumor growth of PTC by targeted regulation of adenomatous polyposis coli APC expression and activating the Wnt/β-catenin signaling; Further studies revealed that APC is a novel miR-155 target because miR-155 bound directly to its 3'-untranslated region and reduced both the mRNA and protein levels of APC; Similar to the miR-155 over-expression APC downregulation promoted cell growth whereas rescued APC expression reversed the promotive effect of miR-155; By targeting APC miR-155 efficiently regulates the Wnt/β-catenin signaling thyroid cancer hsa-miR-375 APLF 2.09893673049766 1.68351780396203e-16 -0.950239740782094 1.61527175884475e-17 miRanda -0.15495698605645 1.78965177639779e-26 NA NA NA hsa-miR-375 APOB 2.09893673049766 1.68351780396203e-16 -5.95582623532149 2.97231616769097e-92 miRanda -0.285489398654386 2.7787345974269e-11 NA NA NA hsa-miR-142-3p APOD 1.53951237846104 2.06769936282034e-17 -3.11762017957986 4.54379742348552e-30 miRanda -0.240378973376845 4.4701503537348e-06 NA NA NA hsa-miR-375 AQP4 2.09893673049766 1.68351780396203e-16 -2.94944371494166 1.54083437012241e-32 miRanda -0.168807277393739 6.53176799420112e-07 NA NA NA hsa-miR-28-5p ARAF -0.14267073663385 0.0497619246260571 0.235957457636243 1.23308070405748e-05 miRanda -0.105409266420207 4.05384033466484e-05 NA NA NA hsa-miR-107 AREG 0.678998026350662 2.56224148930538e-16 -0.778303606133199 0.00739078553830674 miRanda -0.406038762215162 0.000634360053700675 NA NA NA hsa-miR-330-5p AREG 0.626063225953928 3.42215028606779e-09 -0.778303606133199 0.00739078553830674 miRanda -0.335793060377933 0.000327824351427213 NA NA NA hsa-miR-590-3p AREG 1.27438512890514 1.03164723481469e-23 -0.778303606133199 0.00739078553830674 miRanda -0.406562840780303 3.20287409706028e-07 NA NA NA hsa-miR-28-5p ARHGAP32 -0.14267073663385 0.0497619246260571 0.428981349890582 9.04481455196716e-05 miRanda -0.357813655513258 4.69862929924358e-12 NA NA NA hsa-miR-28-5p ARHGAP8 -0.14267073663385 0.0497619246260571 1.29054868351649 1.27181467936902e-24 miRanda -0.123720338679521 0.0455894799146789 NA NA NA hsa-miR-28-5p ARHGEF16 -0.14267073663385 0.0497619246260571 1.35329840541901 1.42152949394676e-31 miRanda -0.311713075778674 4.38350949037839e-08 NA NA NA hsa-miR-155-5p ARID2 1.09766314984151 4.55650930885814e-15 0.0126196265480711 0.870504230097088 miRTarBase -0.134927327264409 1.95731958346401e-13 27035278 MicroRNA 155 promotes tumor growth of human hepatocellular carcinoma by targeting ARID2 liver cancer hsa-miR-28-5p ARL17A -0.14267073663385 0.0497619246260571 -0.076616628706041 0.376773217715529 miRanda -0.116838808707706 0.00459030737152711 NA NA NA hsa-miR-429 ARL4A 2.84108892259147 3.88520896426515e-64 -1.62430631843352 2.32437289801249e-48 miRanda -0.18435268560897 4.66208880927508e-17 NA NA NA hsa-miR-28-5p ARL6IP4 -0.14267073663385 0.0497619246260571 0.502725444320326 1.62774393703499e-06 miRanda -0.187164035456642 0.000188216832903953 NA NA NA hsa-miR-28-5p ARMC5 -0.14267073663385 0.0497619246260571 0.672611492140303 1.59874426366769e-13 miRanda -0.281851896737958 1.02406182812613e-10 NA NA NA hsa-miR-28-5p ARMC7 -0.14267073663385 0.0497619246260571 0.786794624029855 9.0622398933339e-30 miRanda -0.125003459010202 0.000256153442255009 NA NA NA hsa-miR-28-5p ARMC9 -0.14267073663385 0.0497619246260571 1.05145638032088 4.80180385675785e-40 miRanda -0.181814932736477 4.29206202175496e-06 NA NA NA hsa-miR-28-5p ASB8 -0.14267073663385 0.0497619246260571 -0.209242682677155 0.000120963170245691 miRanda -0.187314696249896 2.48215666088341e-13 NA NA NA hsa-miR-28-5p ATPAF1 -0.14267073663385 0.0497619246260571 -0.162517192737524 0.00531751879757489 miRanda -0.121883670377972 1.03894860881348e-05 NA NA NA hsa-miR-28-5p ATRNL1 -0.14267073663385 0.0497619246260571 -0.735629381854826 0.0208064652732134 miRanda -0.528569962012974 0.000487200551841339 NA NA NA hsa-miR-375 AVPR1A 2.09893673049766 1.68351780396203e-16 -2.10367215895108 3.94317714451875e-27 miRanda -0.107652595021722 4.92756746945447e-05 NA NA NA hsa-miR-15b-5p AXIN2 0.788659356634696 1.13678211092534e-11 -0.895665130901764 2.13015726395378e-12 miRTarBase -0.249089153159517 2.51640038854339e-11 NA NA NA hsa-miR-28-5p B3GALT4 -0.14267073663385 0.0497619246260571 0.463435175029749 5.58445598817781e-06 miRanda -0.144809845762043 0.00301366337812068 NA NA NA hsa-miR-28-5p BAG1 -0.14267073663385 0.0497619246260571 0.415270048181819 1.74825976512713e-05 miRanda -0.307899469150691 1.6573691753667e-11 NA NA NA hsa-miR-375 BAHCC1 2.09893673049766 1.68351780396203e-16 -0.346869553943518 0.00681890850135577 miRanda -0.109337268820015 6.76809747547893e-11 NA NA NA hsa-miR-107 BBOX1 0.678998026350662 2.56224148930538e-16 -3.61875191900481 2.18406838030692e-25 miRanda -0.811376131667331 2.50767341313023e-08 NA NA NA hsa-miR-342-3p BBOX1 1.21944481975657 6.81914373001202e-19 -3.61875191900481 2.18406838030692e-25 miRanda -0.838175192355231 9.33492780947674e-23 NA NA NA hsa-miR-28-5p BBS1 -0.14267073663385 0.0497619246260571 -0.0933887460229856 0.273588503662833 miRanda -0.28940058756879 4.91592702721265e-13 NA NA NA hsa-miR-28-5p BCAM -0.14267073663385 0.0497619246260571 0.514670465767451 0.00080836907714589 miRanda -0.64381725099197 3.09853416103942e-19 NA NA NA hsa-miR-375 BCL11B 2.09893673049766 1.68351780396203e-16 -0.256836470376791 0.197473897494306 miRanda -0.164781850839961 2.44247942885145e-10 NA NA NA hsa-miR-148a-3p BCL2 0.706969798912638 5.52538085480485e-09 -0.895845361347303 1.04475176246219e-07 miRTarBase -0.220300574731754 3.43414567895446e-06 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-15a-5p BCL2 0.812445324157528 4.50263417099822e-20 -0.895845361347303 1.04475176246219e-07 miRTarBase -0.390139881240154 1.08000528360666e-09 25594541;22335947;26915294;18931683;25623762 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells ;;poor survival;;drug resistance breast cancer;breast cancer;lung cancer;prostate cancer;colon cancer hsa-miR-15b-5p BCL2 0.788659356634696 1.13678211092534e-11 -0.895845361347303 1.04475176246219e-07 miRTarBase -0.282455107593279 9.40085716451768e-09 25594541;26915294;26884837;18449891 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;poor survival;;drug resistance breast cancer;lung cancer;liver cancer;gastric cancer hsa-miR-21-5p BCL2 2.32007501846389 3.08394781855554e-137 -0.895845361347303 1.04475176246219e-07 miRTarBase -0.486116466611641 4.94993012898121e-21 26555418;21468550;25994220;25381586;23359184;22964582;21376256 The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance breast cancer;bladder cancer;colorectal cancer;sarcoma;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-375 BCL2L14 2.09893673049766 1.68351780396203e-16 -0.132595342308931 0.582047414772611 miRanda -0.160600909480514 3.69079254561893e-07 NA NA NA hsa-miR-155-5p BCL6 1.09766314984151 4.55650930885814e-15 -1.26229162888298 9.95816785471049e-39 miRTarBase -0.101761215913956 3.11208646260481e-05 23169640 We show that Bcl6 is indirectly regulated by miR-155 through Mxd1/Mad1 up-regulation; Interestingly we found that miR-155 directly targets HDAC4 a corepressor partner of BCL6; Meta-analysis of the diffuse large B-cell lymphoma patient microarray data showed that miR-155 expression is inversely correlated with Bcl6 and Hdac4; Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias poor survival B cell lymphoma hsa-miR-375 BEND6 2.09893673049766 1.68351780396203e-16 0.598060035281371 2.48277797233464e-05 miRanda -0.127373899846287 6.9662752836418e-12 NA NA NA hsa-miR-28-5p BHLHE40 -0.14267073663385 0.0497619246260571 0.408671974638585 0.000468982708659732 miRanda -0.470045059510164 8.62962982184735e-18 NA NA NA hsa-miR-15a-5p BMI1 0.812445324157528 4.50263417099822e-20 0.317642163654291 0.000513144270188165 miRTarBase -0.106371353467624 0.0022559342681427 27596816 Our results suggest that overexpression of miR-15a and miR-16 mediates down-regulation of BMI1 and leads to mitochondrial mediated apoptosis breast cancer hsa-miR-21-5p BMPR2 2.32007501846389 3.08394781855554e-137 -0.619963448559116 4.34614935044474e-16 miRTarBase -0.217097837256464 4.31156278024056e-20 NA NA NA hsa-miR-155-5p BRPF3 1.09766314984151 4.55650930885814e-15 0.0924754751249477 0.205867037581768 miRTarBase -0.103778340901283 2.6202915395585e-09 NA NA NA hsa-miR-21-5p BTG2 2.32007501846389 3.08394781855554e-137 -0.809620825866558 5.59677057319634e-08 miRTarBase -0.271889515348514 4.86541229128609e-09 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2 tumorigenesis gastric cancer hsa-miR-28-5p BTRC -0.14267073663385 0.0497619246260571 0.120536048906525 0.159286798668058 miRanda -0.245382923565365 1.23962341723426e-09 NA NA NA hsa-miR-193a-3p C7 0.310617999804917 0.00477640270974957 -3.45742684125147 4.60513107256491e-21 miRanda -0.724997605362124 4.69875716710449e-10 NA NA NA hsa-miR-330-5p C7 0.626063225953928 3.42215028606779e-09 -3.45742684125147 4.60513107256491e-21 miRanda -0.787501956761179 5.08468856687708e-11 NA NA NA hsa-miR-375 C7 2.09893673049766 1.68351780396203e-16 -3.45742684125147 4.60513107256491e-21 miRanda -0.162163335989875 0.00108377995115516 NA NA NA hsa-miR-590-3p C7 1.27438512890514 1.03164723481469e-23 -3.45742684125147 4.60513107256491e-21 miRanda -0.790290697516293 8.86524731598188e-15 NA NA NA hsa-miR-590-5p C7 0.746515607868274 8.51300479640125e-09 -3.45742684125147 4.60513107256491e-21 miRanda -0.870175238139762 2.49655685203604e-19 NA NA NA hsa-miR-361-5p CAB39L -0.0996867547900457 0.095428250126326 -1.41958178424988 2.17824679172429e-35 miRanda -0.330966403252337 1.83182973451587e-06 NA NA NA hsa-miR-542-3p CAB39L 0.568822103820889 8.5699075257651e-07 -1.41958178424988 2.17824679172429e-35 miRanda -0.121425444114793 0.000573284574798606 NA NA NA hsa-miR-590-3p CAB39L 1.27438512890514 1.03164723481469e-23 -1.41958178424988 2.17824679172429e-35 miRanda -0.29325120657851 6.63397632520721e-20 NA NA NA hsa-miR-590-5p CAB39L 0.746515607868274 8.51300479640125e-09 -1.41958178424988 2.17824679172429e-35 miRanda -0.268274576531643 2.66310373376075e-18 NA NA NA hsa-miR-28-5p CACNG4 -0.14267073663385 0.0497619246260571 2.21159891256783 3.76360584804154e-13 miRanda -0.632449765922558 1.63314781237986e-05 NA NA NA hsa-miR-15a-5p CADM1 0.812445324157528 4.50263417099822e-20 -0.0699204971408882 0.585878770512374 miRTarBase -0.199087358235994 4.24758390787005e-05 NA NA NA hsa-miR-28-5p CALCOCO1 -0.14267073663385 0.0497619246260571 -1.08289042748634 4.79337264485307e-51 miRanda -0.143823356702789 8.02577597264752e-05 NA NA NA hsa-miR-28-5p CALCOCO2 -0.14267073663385 0.0497619246260571 -0.438580916376234 2.42826269547857e-08 miRanda -0.198957671269254 1.11358465771385e-07 NA NA NA hsa-miR-28-5p CANT1 -0.14267073663385 0.0497619246260571 1.19121908849889 2.01312112605851e-40 miRanda -0.31350040187146 1.39014322710422e-12 NA NA NA hsa-miR-324-5p CAPN6 0.211552647440779 0.139408130311654 -3.62270638284474 1.23690757569109e-25 miRanda -0.177069163796064 0.0388684902231593 NA NA NA hsa-miR-330-5p CAPN6 0.626063225953928 3.42215028606779e-09 -3.62270638284474 1.23690757569109e-25 miRanda -0.309977796008379 0.00699589956354002 NA NA NA hsa-miR-429 CAPN6 2.84108892259147 3.88520896426515e-64 -3.62270638284474 1.23690757569109e-25 miRanda -0.416985047131177 4.99303572048637e-10 NA NA NA hsa-miR-28-5p CASC2 -0.14267073663385 0.0497619246260571 -0.0591451463253274 0.56145154040616 miRanda -0.214324545590939 9.02943345410797e-06 NA NA NA hsa-miR-103a-3p CAV1 0.610673390034345 1.63113920514646e-12 -3.35468478136284 1.45542787428009e-122 miRTarBase -0.515198749652868 1.17666438639598e-15 NA NA NA hsa-miR-142-3p CAV1 1.53951237846104 2.06769936282034e-17 -3.35468478136284 1.45542787428009e-122 miRanda -0.236540250499484 5.84719165208748e-15 NA NA NA hsa-miR-320b CAV1 0.412787504747938 0.00113457276903985 -3.35468478136284 1.45542787428009e-122 miRanda -0.211277586283733 2.59185013197257e-06 NA NA NA hsa-miR-342-3p CAV1 1.21944481975657 6.81914373001202e-19 -3.35468478136284 1.45542787428009e-122 miRanda -0.366982754565586 2.34789160865919e-20 NA NA NA hsa-miR-28-5p CCDC113 -0.14267073663385 0.0497619246260571 0.149223101788104 0.136932129872727 miRanda -0.148195425613187 0.00190132838114588 NA NA NA hsa-miR-28-5p CCDC114 -0.14267073663385 0.0497619246260571 1.16840637134549 3.00376939451887e-11 miRanda -0.296693787504866 0.000456912265203965 NA NA NA hsa-miR-375 CCDC129 2.09893673049766 1.68351780396203e-16 -2.66028470423133 3.26429184948124e-17 miRanda -0.283502628080528 1.4321883306984e-11 NA NA NA hsa-miR-375 CCDC80 2.09893673049766 1.68351780396203e-16 -1.64278449223908 9.9933942504804e-25 miRanda -0.161951468589364 4.15709577186341e-14 NA NA NA hsa-miR-28-5p CCDC85A -0.14267073663385 0.0497619246260571 -2.63514416883509 8.247493889982e-55 miRanda -0.198190978658007 0.0217102405686434 NA NA NA hsa-miR-28-5p CCDC87 -0.14267073663385 0.0497619246260571 1.38078268229956 9.83612478312899e-22 miRanda -0.498038418591484 8.14796611713182e-13 NA NA NA hsa-miR-15b-5p CCND1 0.788659356634696 1.13678211092534e-11 0.789100261201456 1.48424202389562e-06 miRTarBase -0.125463191460891 0.00921827566968511 NA NA NA hsa-miR-15a-5p CCND2 0.812445324157528 4.50263417099822e-20 -1.32381712777542 1.10807863083966e-33 miRTarBase -0.382989347535057 1.85935181542133e-19 NA NA NA hsa-miR-28-5p CCNDBP1 -0.14267073663385 0.0497619246260571 -0.725809699931222 3.00753297514094e-26 miRanda -0.172490460917306 2.48035110164691e-07 NA NA NA hsa-miR-28-5p CCNG2 -0.14267073663385 0.0497619246260571 -0.149650768150032 0.140842306998986 miRanda -0.202065115294172 2.7892462854838e-05 NA NA NA hsa-miR-28-5p CD2BP2 -0.14267073663385 0.0497619246260571 0.7295100071912 3.69314996005442e-25 miRanda -0.242214534749734 1.19789821252281e-12 NA NA NA hsa-miR-590-3p CD36 1.27438512890514 1.03164723481469e-23 -4.94005353360482 1.40138697698687e-80 miRanda -0.663949960911294 1.17669595718115e-17 NA NA NA hsa-miR-375 CD3G 2.09893673049766 1.68351780396203e-16 -0.255569353658802 0.270972373770412 miRanda -0.128112752370268 2.70123195444446e-05 NA NA NA hsa-miR-28-5p CDH18 -0.14267073663385 0.0497619246260571 -0.0522684838785148 0.841570242720998 miRanda -0.338750908305708 0.00650983425165781 NA NA NA hsa-miR-28-5p CDH7 -0.14267073663385 0.0497619246260571 1.31238154715945 1.99846237004699e-05 miRanda -0.556872122656275 0.000151564494061746 NA NA NA hsa-miR-28-5p CDK17 -0.14267073663385 0.0497619246260571 -0.124778185173291 0.119991532413407 miRanda -0.2679902930505 1.16916140085302e-12 NA NA NA hsa-miR-28-5p CDK5 -0.14267073663385 0.0497619246260571 1.49472759404501 6.61129562064286e-69 miRanda -0.232036778076655 1.32632021154552e-07 NA NA NA hsa-miR-28-5p CDKN1A -0.14267073663385 0.0497619246260571 -0.254319078213554 0.025069242968496 miRTarBase;miRanda -0.294350864895331 4.29596264827348e-08 NA NA NA hsa-miR-107 CDKN1C 0.678998026350662 2.56224148930538e-16 -2.10696277121193 3.07611963088364e-54 miRanda -0.269063282417449 5.61144663419198e-06 NA NA NA hsa-miR-320b CDKN1C 0.412787504747938 0.00113457276903985 -2.10696277121193 3.07611963088364e-54 miRanda -0.161770248369663 4.03547815709149e-05 NA NA NA hsa-miR-590-3p CDKN1C 1.27438512890514 1.03164723481469e-23 -2.10696277121193 3.07611963088364e-54 miRanda -0.363234776678318 1.44662811954727e-20 NA NA NA hsa-miR-92b-3p CDKN1C 1.30248132773644 9.42428674470985e-25 -2.10696277121193 3.07611963088364e-54 miRTarBase -0.367993702468557 5.00703264967851e-23 NA NA NA hsa-miR-28-5p CDON -0.14267073663385 0.0497619246260571 -0.991164686357028 8.70119211480039e-13 miRanda -0.218069047933018 0.00111790580801383 NA NA NA hsa-miR-28-5p CEACAM6 -0.14267073663385 0.0497619246260571 3.14788813465337 6.1411751537789e-15 miRanda -1.28041560860565 3.67270918208962e-11 NA NA NA hsa-miR-28-5p CEACAM7 -0.14267073663385 0.0497619246260571 1.13710462023162 6.55115186081843e-05 miRanda -1.0999950998306 2.08904069363437e-16 NA NA NA hsa-miR-320b CES1 0.412787504747938 0.00113457276903985 -4.24370755636762 1.71433450685894e-61 miRanda -0.400976380778458 8.44956921874983e-08 NA NA NA hsa-miR-28-5p CHAD -0.14267073663385 0.0497619246260571 -0.0030842411669636 0.993051648329624 miRanda -0.898299919129268 8.28846753994342e-08 NA NA NA hsa-miR-28-5p CHD3 -0.14267073663385 0.0497619246260571 0.23471658817734 0.000437572538712428 miRanda -0.14699452182334 3.51869616627388e-06 NA NA NA hsa-miR-28-5p CHDH -0.14267073663385 0.0497619246260571 0.0931083294714723 0.508817983929441 miRanda -0.296667633251818 9.04941339500822e-06 NA NA NA hsa-miR-375 CHODL 2.09893673049766 1.68351780396203e-16 -2.01433678971644 3.11757059994944e-14 miRanda -0.477636573777808 8.20219259497187e-46 NA NA NA hsa-miR-342-3p CHRDL1 1.21944481975657 6.81914373001202e-19 -5.39923527570506 3.1404637677735e-65 miRanda -0.612329807291896 1.49343398027114e-13 NA NA NA hsa-miR-429 CHRDL1 2.84108892259147 3.88520896426515e-64 -5.39923527570506 3.1404637677735e-65 miRanda -0.74685625804435 8.95614370149719e-33 NA NA NA hsa-miR-590-3p CHRDL1 1.27438512890514 1.03164723481469e-23 -5.39923527570506 3.1404637677735e-65 miRanda -0.592716673504134 2.43716369762286e-10 NA NA NA hsa-miR-615-3p CHRDL1 0.659240580933614 0.000360214386152507 -5.39923527570506 3.1404637677735e-65 miRanda -0.264118331154372 3.17857157296859e-05 NA NA NA hsa-miR-15a-5p CHUK 0.812445324157528 4.50263417099822e-20 -0.0655383466936339 0.252025603609673 miRTarBase -0.135155500445723 3.1799004977298e-10 NA NA NA hsa-miR-324-5p CIDEA 0.211552647440779 0.139408130311654 -6.40951654374914 4.94175069970974e-54 miRanda -0.725116852279481 5.19294198233606e-12 NA NA NA hsa-miR-28-5p CLASP2 -0.14267073663385 0.0497619246260571 -0.480530283040537 1.81219003638834e-11 miRanda -0.162061212588336 2.27538557457813e-06 NA NA NA hsa-miR-15a-5p CLCN3 0.812445324157528 4.50263417099822e-20 -0.318465310544011 0.00161725958250904 miRTarBase -0.395372113254194 3.13932643906598e-26 NA NA NA hsa-miR-326 CLDN5 -1.54449030848141 1.04703417845594e-17 -2.72483011134506 3.29503816897549e-48 miRanda -0.110435728339444 0.00283482133907246 NA NA NA hsa-miR-330-5p CLDN5 0.626063225953928 3.42215028606779e-09 -2.72483011134506 3.29503816897549e-48 miRanda -0.683622797241835 1.7261808299844e-28 NA NA NA hsa-miR-125a-3p CLDN8 -0.176412960953959 0.10108079286419 -2.40586022995905 3.18872712875525e-15 miRanda -0.354274069725054 0.000363434786114532 NA NA NA hsa-miR-330-5p CLDN8 0.626063225953928 3.42215028606779e-09 -2.40586022995905 3.18872712875525e-15 miRanda -0.411088735137809 3.70890206125894e-05 NA NA NA hsa-miR-590-3p CLDN8 1.27438512890514 1.03164723481469e-23 -2.40586022995905 3.18872712875525e-15 miRanda -0.307009878361463 0.000316117392420876 NA NA NA hsa-miR-375 CLEC2B 2.09893673049766 1.68351780396203e-16 -0.752784538838791 4.80096301835902e-13 miRanda -0.105410776848508 1.52461699785913e-14 NA NA NA hsa-miR-28-5p CNKSR1 -0.14267073663385 0.0497619246260571 1.44823291536679 2.12293533329982e-27 miRanda -0.136690806427665 0.0378724954718156 NA NA NA hsa-miR-375 CNKSR2 2.09893673049766 1.68351780396203e-16 -3.49949785208655 1.01602507278623e-50 miRanda -0.349065238847428 4.76518398813731e-28 NA NA NA hsa-miR-330-5p CNN1 0.626063225953928 3.42215028606779e-09 -3.24406644714213 3.24560680059697e-62 miRanda -0.681253505167957 4.79445871909418e-25 NA NA NA hsa-miR-375 CNRIP1 2.09893673049766 1.68351780396203e-16 -1.6721946883908 3.98165243204626e-54 miRanda -0.112022644304228 8.93881769885715e-14 NA NA NA hsa-miR-590-3p COL17A1 1.27438512890514 1.03164723481469e-23 -3.55889143097104 1.4248444409867e-23 miRanda -0.842552632160707 1.37295805012509e-17 NA NA NA hsa-miR-28-5p COL3A1 -0.14267073663385 0.0497619246260571 1.50470077229731 1.9069386527602e-18 miRanda -0.217177944731906 0.00939470887863092 NA NA NA hsa-miR-28-5p COL6A3 -0.14267073663385 0.0497619246260571 0.634653480531805 2.31261246968383e-05 miRanda -0.142973027863578 0.0465166725475489 NA NA NA hsa-miR-375 COL6A6 2.09893673049766 1.68351780396203e-16 -4.13623144944441 2.15085613287136e-58 miRanda -0.280960121016173 5.00098926026836e-15 NA NA NA hsa-miR-28-5p COMMD3 -0.14267073663385 0.0497619246260571 0.675388089068306 6.93374609568002e-19 miRanda -0.134682275248439 0.000267418960162858 NA NA NA hsa-miR-28-5p COPG2 -0.14267073663385 0.0497619246260571 0.248679199189896 0.000341940906197054 miRanda -0.181006340148697 3.74563245844575e-08 NA NA NA hsa-miR-375 CP 2.09893673049766 1.68351780396203e-16 -1.67217844088781 1.34727302241253e-05 miRanda -0.442494373718394 7.25966583414107e-19 NA NA NA hsa-miR-28-5p CPD -0.14267073663385 0.0497619246260571 -0.241449324374273 0.0207834781120828 miRanda -0.259823794381588 1.4995780268069e-07 NA NA NA hsa-miR-142-3p CPE 1.53951237846104 2.06769936282034e-17 -1.2306475289771 6.06559656904635e-18 miRanda -0.252447129723344 8.11932786491594e-22 NA NA NA hsa-miR-146b-5p CPE 0.631041661167954 6.20366593452965e-08 -1.2306475289771 6.06559656904635e-18 miRanda -0.360957953888663 5.40183636220358e-18 NA NA NA hsa-miR-320b CPE 0.412787504747938 0.00113457276903985 -1.2306475289771 6.06559656904635e-18 miRanda -0.200001280807419 3.66971306910933e-07 NA NA NA hsa-miR-429 CPE 2.84108892259147 3.88520896426515e-64 -1.2306475289771 6.06559656904635e-18 miRanda -0.264661954056953 6.75283545887745e-23 NA NA NA hsa-miR-590-3p CPE 1.27438512890514 1.03164723481469e-23 -1.2306475289771 6.06559656904635e-18 miRanda -0.408295241119329 7.30888687195261e-26 NA NA NA hsa-miR-375 CPEB1 2.09893673049766 1.68351780396203e-16 -2.57128181037364 6.48452220778867e-39 miRanda -0.101732255089729 0.000187786847392762 NA NA NA hsa-miR-375 CPM 2.09893673049766 1.68351780396203e-16 -1.86998255407086 2.3046292197309e-45 miRanda -0.122363029188272 2.11081648785383e-11 NA NA NA hsa-miR-375 CPNE8 2.09893673049766 1.68351780396203e-16 -1.3845742448351 1.45815071649029e-28 miRanda -0.193445325318429 4.65847148522686e-32 NA NA NA hsa-miR-28-5p CRADD -0.14267073663385 0.0497619246260571 -0.251683647119455 0.000231223686713744 miRanda -0.235221289528442 2.61428453267022e-13 NA NA NA hsa-miR-28-5p CREBL2 -0.14267073663385 0.0497619246260571 -0.828924810318552 7.72831390224407e-35 miRanda -0.118954483680499 0.000365495180109717 NA NA NA hsa-miR-375 CRISPLD1 2.09893673049766 1.68351780396203e-16 -1.88756141169747 8.99779553823236e-17 miRanda -0.257158420874287 8.75797086933372e-18 NA NA NA hsa-miR-28-5p CROT -0.14267073663385 0.0497619246260571 0.037293899986957 0.777067375226551 miRanda -0.437819717941343 1.51683811218234e-12 NA NA NA hsa-miR-28-5p CRY2 -0.14267073663385 0.0497619246260571 -1.19975346543936 7.77211531373058e-53 miRanda -0.215089887065039 5.72190749767741e-08 NA NA NA hsa-miR-590-3p CRYAB 1.27438512890514 1.03164723481469e-23 -3.89991449136262 2.65721676264208e-57 miRanda -0.162434124497098 0.0246656739110602 NA NA NA hsa-miR-590-3p CSN1S1 1.27438512890514 1.03164723481469e-23 -4.56741152547387 1.1732693469515e-60 miRanda -0.491068264325025 1.96466528413348e-09 NA NA NA hsa-miR-590-5p CSN1S1 0.746515607868274 8.51300479640125e-09 -4.56741152547387 1.1732693469515e-60 miRanda -0.220626975716374 0.00514468569721685 NA NA NA hsa-miR-155-5p CSNK1A1 1.09766314984151 4.55650930885814e-15 0.188208571372272 0.000892405027068843 miRTarBase -0.112093319289922 5.71697685710134e-17 NA NA NA hsa-miR-375 CTGF 2.09893673049766 1.68351780396203e-16 -0.492053877527233 0.000535095367324139 miRanda -0.104861961985773 1.91267729749617e-08 NA NA NA hsa-miR-375 CUBN 2.09893673049766 1.68351780396203e-16 -1.92999004425265 2.52844875363356e-61 miRanda -0.186847775291894 2.21572590504544e-31 NA NA NA hsa-miR-590-3p CX3CL1 1.27438512890514 1.03164723481469e-23 -2.71182430422596 3.50152905238866e-53 miRanda -0.14422189370023 0.00548011384628063 NA NA NA hsa-miR-320b CXCL12 0.412787504747938 0.00113457276903985 -2.12095060237474 3.84001932998671e-54 miRanda -0.243993417539567 6.20238010298801e-10 NA NA NA hsa-miR-375 CXCL12 2.09893673049766 1.68351780396203e-16 -2.12095060237474 3.84001932998671e-54 miRanda -0.130667047793173 8.04931756867824e-12 NA NA NA hsa-miR-429 CXCL12 2.84108892259147 3.88520896426515e-64 -2.12095060237474 3.84001932998671e-54 miRanda -0.378344732495558 2.69106217688879e-47 NA NA NA hsa-miR-590-3p CXCL12 1.27438512890514 1.03164723481469e-23 -2.12095060237474 3.84001932998671e-54 miRanda -0.38652358664164 6.84901353457739e-23 NA NA NA hsa-miR-193a-3p CXCL2 0.310617999804917 0.00477640270974957 -4.41801021215951 3.03052270999203e-65 miRanda -0.308535068216592 0.000431206795137317 NA NA NA hsa-miR-375 CXCL6 2.09893673049766 1.68351780396203e-16 -1.94795420724642 3.10169096356284e-12 miRanda -0.300338474424163 2.80312431457939e-16 NA NA NA hsa-miR-320b CYBRD1 0.412787504747938 0.00113457276903985 -1.65279857617782 2.59153209850489e-26 miRanda -0.250522458570684 7.46409451118511e-09 NA NA NA hsa-miR-324-5p CYBRD1 0.211552647440779 0.139408130311654 -1.65279857617782 2.59153209850489e-26 miRanda -0.318524198488547 3.86034152186855e-17 NA NA NA hsa-miR-339-5p CYBRD1 -0.211548290465418 0.0685885445822389 -1.65279857617782 2.59153209850489e-26 miRanda -0.147033927135952 0.00198405759050958 NA NA NA hsa-miR-429 CYBRD1 2.84108892259147 3.88520896426515e-64 -1.65279857617782 2.59153209850489e-26 miRanda -0.307914193462445 2.19974221683058e-25 NA NA NA hsa-miR-590-3p CYBRD1 1.27438512890514 1.03164723481469e-23 -1.65279857617782 2.59153209850489e-26 miRanda -0.492763037394036 5.98382433665322e-31 NA NA NA hsa-miR-375 CYP7B1 2.09893673049766 1.68351780396203e-16 -1.30562641941586 1.13663571946736e-17 miRanda -0.18710371144923 1.11648436123317e-20 NA NA NA hsa-miR-28-5p CYTH2 -0.14267073663385 0.0497619246260571 0.702575167222823 2.04335535926724e-21 miRanda -0.196402252030897 4.26017752822191e-08 NA NA NA hsa-miR-28-5p DALRD3 -0.14267073663385 0.0497619246260571 0.592133186684577 7.32758102420887e-12 miRanda -0.448285991408448 8.89585675977247e-29 NA NA NA hsa-miR-28-5p DAZAP2 -0.14267073663385 0.0497619246260571 0.0462419874292657 0.329536160227049 miRanda -0.167753753611657 3.68313522146614e-14 NA NA NA hsa-miR-375 DCHS2 2.09893673049766 1.68351780396203e-16 -1.99755662696167 1.4190733423489e-21 miRanda -0.305804488761682 6.03783381030593e-29 NA NA NA hsa-miR-146b-5p DCLK1 0.631041661167954 6.20366593452965e-08 -1.46888367029758 2.60502733473862e-12 miRanda -0.396463051256276 1.2547465865475e-10 NA NA NA hsa-miR-320b DCLK1 0.412787504747938 0.00113457276903985 -1.46888367029758 2.60502733473862e-12 miRanda -0.123272178364535 0.0331013328565324 NA NA NA hsa-miR-429 DCLK1 2.84108892259147 3.88520896426515e-64 -1.46888367029758 2.60502733473862e-12 miRanda -0.265376834990967 2.84194985692894e-11 NA NA NA hsa-miR-590-3p DCLK1 1.27438512890514 1.03164723481469e-23 -1.46888367029758 2.60502733473862e-12 miRanda -0.41394625752512 7.55707818624954e-13 NA NA NA hsa-miR-320b DCN 0.412787504747938 0.00113457276903985 -2.24189494854445 3.67472421736277e-35 miRanda -0.29535554536257 7.09538047060049e-09 NA NA NA hsa-miR-342-3p DCN 1.21944481975657 6.81914373001202e-19 -2.24189494854445 3.67472421736277e-35 miRanda -0.287211968356635 3.67914088909684e-10 NA NA NA hsa-miR-590-3p DCN 1.27438512890514 1.03164723481469e-23 -2.24189494854445 3.67472421736277e-35 miRanda -0.52916176505448 1.07716522597725e-25 NA NA NA hsa-miR-375 DDX43 2.09893673049766 1.68351780396203e-16 -1.993053537538 2.04227770475839e-15 miRanda -0.202908183149824 1.269954641273e-09 NA NA NA hsa-miR-28-5p DDX60 -0.14267073663385 0.0497619246260571 0.258448146031201 0.049511423209945 miRanda -0.124121210231133 0.0479397801929396 NA NA NA hsa-miR-155-5p DET1 1.09766314984151 4.55650930885814e-15 -0.487136043364508 7.81665524281748e-14 miRTarBase -0.144443169600792 1.57687300539907e-20 NA NA NA hsa-miR-375 DFNA5 2.09893673049766 1.68351780396203e-16 -0.936402345459662 1.93043899322683e-26 miRanda -0.113991292011124 1.58329601826641e-22 NA NA NA hsa-miR-28-5p DHRS2 -0.14267073663385 0.0497619246260571 1.07976211540207 0.0180138769274907 miRanda -1.42153982969568 4.1358623924697e-11 NA NA NA hsa-miR-28-5p DHRS4 -0.14267073663385 0.0497619246260571 0.0781364876424782 0.360324485265141 miRanda -0.252257675076986 3.65800347648958e-10 NA NA NA hsa-miR-28-5p DHRS4L1 -0.14267073663385 0.0497619246260571 -0.0991231860873832 0.44302544820008 miRanda -0.346024158096003 1.45044398203217e-08 NA NA NA hsa-miR-28-5p DHRS4L2 -0.14267073663385 0.0497619246260571 -0.0131580653571994 0.885661344969612 miRanda -0.240307182431194 2.6902141983072e-08 NA NA NA hsa-miR-28-5p DHRS7B -0.14267073663385 0.0497619246260571 -0.227646059774749 0.0024852530623363 miRanda -0.196022437875585 3.73712774456641e-08 NA NA NA hsa-miR-28-5p DHX29 -0.14267073663385 0.0497619246260571 0.0734426982923981 0.254121869868459 miRanda -0.227299174298341 4.81576551681987e-14 NA NA NA hsa-miR-155-5p DHX40 1.09766314984151 4.55650930885814e-15 -0.0461660313788235 0.575518154014288 miRTarBase -0.126704910846177 1.07008259715675e-10 NA NA NA hsa-miR-28-5p DHX58 -0.14267073663385 0.0497619246260571 0.568647882524633 8.82962162841857e-09 miRanda -0.196598808324417 3.29420558267845e-05 NA NA NA hsa-miR-107 DMD 0.678998026350662 2.56224148930538e-16 -3.78348112804436 3.23742415858975e-92 miRanda -0.687902217343895 2.38825896516312e-16 NA NA NA hsa-miR-330-5p DMD 0.626063225953928 3.42215028606779e-09 -3.78348112804436 3.23742415858975e-92 miRanda -0.320410580832054 1.65117772775359e-06 NA NA NA hsa-miR-375 DMD 2.09893673049766 1.68351780396203e-16 -3.78348112804436 3.23742415858975e-92 miRanda -0.342983601522973 5.56133585632587e-39 NA NA NA hsa-miR-429 DMD 2.84108892259147 3.88520896426515e-64 -3.78348112804436 3.23742415858975e-92 miRanda -0.493950274361495 3.27123381882023e-39 NA NA NA hsa-miR-590-3p DMD 1.27438512890514 1.03164723481469e-23 -3.78348112804436 3.23742415858975e-92 miRanda -0.237950036940788 3.19915769889444e-05 NA NA NA hsa-miR-375 DMRT2 2.09893673049766 1.68351780396203e-16 -3.08901844202474 2.98127356930882e-47 miRanda -0.205073995406999 4.25814207834915e-12 NA NA NA hsa-miR-375 DMRT3 2.09893673049766 1.68351780396203e-16 -1.48189589187186 4.02281033296515e-22 miRanda -0.154066966138639 5.01971503200999e-14 NA NA NA hsa-miR-28-5p DNAJA4 -0.14267073663385 0.0497619246260571 0.778974960199304 3.35701271270575e-11 miRanda -0.367555686579116 5.42936568736381e-11 NA NA NA hsa-miR-28-5p DNAJB14 -0.14267073663385 0.0497619246260571 -0.389536819121818 1.15940870921076e-05 miRanda -0.130292186583654 0.00214996577325443 NA NA NA hsa-miR-28-5p DNAJC12 -0.14267073663385 0.0497619246260571 1.43850602777815 2.34358351695651e-08 miRanda -1.08463819946357 3.47364266841502e-19 NA NA NA hsa-miR-28-5p DNMBP -0.14267073663385 0.0497619246260571 -0.666936518001947 1.27257555078449e-08 miRanda -0.284585338956239 3.74226293978231e-07 NA NA NA hsa-miR-21-5p DOCK4 2.32007501846389 3.08394781855554e-137 -0.955337759049208 3.43382447572213e-22 miRTarBase -0.217125422672835 3.28471037417372e-12 NA NA NA hsa-miR-21-5p DOCK7 2.32007501846389 3.08394781855554e-137 -0.589797954349144 1.57377532548304e-11 miRTarBase -0.216996296670502 1.28480631069162e-15 NA NA NA hsa-miR-28-5p DPH1 -0.14267073663385 0.0497619246260571 -0.0275786670934695 0.663368667669771 miRanda -0.13551892924721 6.16360587687299e-06 NA NA NA hsa-miR-28-5p DPP3 -0.14267073663385 0.0497619246260571 1.58410857657904 3.35818668883493e-77 miRanda -0.185549722751376 3.15204874454426e-05 NA NA NA hsa-miR-590-3p DPT 1.27438512890514 1.03164723481469e-23 -3.40162217589106 2.15903385902036e-56 miRanda -0.619722220327798 1.06805928243449e-23 NA NA NA hsa-miR-375 DPYSL2 2.09893673049766 1.68351780396203e-16 -1.55582360892426 1.0041511217522e-60 miRanda -0.135491498191147 3.96327133933738e-25 NA NA NA hsa-miR-28-5p DQX1 -0.14267073663385 0.0497619246260571 3.64196683187679 4.5119403521697e-36 miRanda -0.792329778275761 3.56456901527464e-08 NA NA NA hsa-miR-125a-3p DST -0.176412960953959 0.10108079286419 -2.65768728199613 1.49859497194328e-82 miRanda -0.102173740759136 0.0376673770852858 NA NA NA hsa-miR-330-5p DST 0.626063225953928 3.42215028606779e-09 -2.65768728199613 1.49859497194328e-82 miRanda -0.331826848273591 1.00755401760864e-11 NA NA NA hsa-miR-429 DST 2.84108892259147 3.88520896426515e-64 -2.65768728199613 1.49859497194328e-82 miRanda -0.335369004875444 2.7974997525439e-33 NA NA NA hsa-miR-590-3p DST 1.27438512890514 1.03164723481469e-23 -2.65768728199613 1.49859497194328e-82 miRanda -0.362948210353927 1.45993733309567e-18 NA NA NA hsa-miR-28-5p DTWD2 -0.14267073663385 0.0497619246260571 -0.261106719372882 0.00652226445516583 miRanda -0.319410509963769 1.55805399694254e-12 NA NA NA hsa-miR-429 DUSP1 2.84108892259147 3.88520896426515e-64 -2.09516763518402 5.67014496179034e-44 miRanda -0.372780864262415 2.28853225919904e-38 NA NA NA hsa-miR-342-3p DUSP6 1.21944481975657 6.81914373001202e-19 -1.66407181311899 8.17228231309969e-41 miRanda -0.222339440435746 1.94431655220102e-12 NA NA NA hsa-miR-590-3p DUSP6 1.27438512890514 1.03164723481469e-23 -1.66407181311899 8.17228231309969e-41 miRanda -0.246149773662277 4.37177854970617e-12 NA NA NA hsa-miR-28-5p DYNC2LI1 -0.14267073663385 0.0497619246260571 -0.00277231382927301 0.963653940981411 miRanda -0.131841275234267 4.59676931998792e-06 NA NA NA hsa-miR-28-5p DYNLL2 -0.14267073663385 0.0497619246260571 0.0640586851492353 0.385985405743691 miRanda -0.138480243677895 7.74924044116613e-05 NA NA NA hsa-miR-28-5p DYNLRB2 -0.14267073663385 0.0497619246260571 0.0266923189330223 0.906740352238072 miRanda -0.964471145480037 9.91972082004647e-20 NA NA NA hsa-miR-342-3p DZIP1 1.21944481975657 6.81914373001202e-19 -1.06531126131458 4.72890562161364e-17 miRanda -0.302673322310748 9.04437128635391e-23 NA NA NA hsa-miR-429 DZIP1 2.84108892259147 3.88520896426515e-64 -1.06531126131458 4.72890562161364e-17 miRanda -0.18626786761918 1.22001045123551e-14 NA NA NA hsa-miR-375 EBF3 2.09893673049766 1.68351780396203e-16 -2.97501614850151 4.64775706799242e-84 miRanda -0.159959488065909 5.47944924917584e-13 NA NA NA hsa-miR-28-5p EDA2R -0.14267073663385 0.0497619246260571 -1.34255111275385 3.98620322593049e-21 miRanda -0.231407177745149 0.000862123744152227 NA NA NA hsa-miR-330-5p EDN3 0.626063225953928 3.42215028606779e-09 -4.59497689622819 4.8661615450989e-32 miRanda -0.860850614465912 2.66576291230952e-11 NA NA NA hsa-miR-375 EDN3 2.09893673049766 1.68351780396203e-16 -4.59497689622819 4.8661615450989e-32 miRanda -0.385116651948935 3.08819018387424e-13 NA NA NA hsa-miR-590-3p EDN3 1.27438512890514 1.03164723481469e-23 -4.59497689622819 4.8661615450989e-32 miRanda -0.672420106584509 1.20298468068831e-09 NA NA NA hsa-miR-615-3p EDN3 0.659240580933614 0.000360214386152507 -4.59497689622819 4.8661615450989e-32 miRanda -0.584561900118998 2.66049005332775e-15 NA NA NA hsa-miR-146b-5p EDNRB 0.631041661167954 6.20366593452965e-08 -2.53325707381385 5.68707207810449e-66 miRanda -0.17255298596801 0.000232047858476276 NA NA NA hsa-miR-330-5p EDNRB 0.626063225953928 3.42215028606779e-09 -2.53325707381385 5.68707207810449e-66 miRanda -0.317421636650052 5.56073779675656e-10 NA NA NA hsa-miR-455-5p EDNRB 0.284641224662773 0.0357572339594277 -2.53325707381385 5.68707207810449e-66 miRanda -0.172198851562032 2.14580772073434e-05 NA NA NA hsa-miR-590-3p EDNRB 1.27438512890514 1.03164723481469e-23 -2.53325707381385 5.68707207810449e-66 miRanda -0.367327587183522 2.16228352058261e-17 NA NA NA hsa-miR-590-5p EDNRB 0.746515607868274 8.51300479640125e-09 -2.53325707381385 5.68707207810449e-66 miRanda -0.297153607749718 9.438519648887e-13 NA NA NA hsa-miR-146b-5p EFHC1 0.631041661167954 6.20366593452965e-08 -0.188105001776109 0.0324631510023546 miRanda -0.240792233725685 8.12184959085012e-22 NA NA NA hsa-miR-590-3p EFHC1 1.27438512890514 1.03164723481469e-23 -0.188105001776109 0.0324631510023546 miRanda -0.184899543175827 7.73081788656589e-15 NA NA NA hsa-miR-107 EGFR 0.678998026350662 2.56224148930538e-16 -3.35228711557446 2.81857446737209e-45 miRanda -0.619981893208437 1.16509488926421e-09 NA NA NA hsa-miR-128-3p EGFR 0.90296715955238 9.925204823863e-23 -3.35228711557446 2.81857446737209e-45 miRTarBase -0.403877837900024 9.67805623106623e-06 NA NA NA hsa-miR-21-5p EGFR 2.32007501846389 3.08394781855554e-137 -3.35228711557446 2.81857446737209e-45 miRTarBase -0.671030468978973 2.34536849626451e-18 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-339-5p EGFR -0.211548290465418 0.0685885445822389 -3.35228711557446 2.81857446737209e-45 miRanda -0.188726254591616 0.0111740246133512 NA NA NA hsa-miR-342-3p EGFR 1.21944481975657 6.81914373001202e-19 -3.35228711557446 2.81857446737209e-45 miRanda -0.737335841516313 4.52090989396721e-36 NA NA NA hsa-miR-375 EGFR 2.09893673049766 1.68351780396203e-16 -3.35228711557446 2.81857446737209e-45 miRanda -0.424868499428666 2.03176717536657e-41 NA NA NA hsa-miR-28-5p EGLN3 -0.14267073663385 0.0497619246260571 1.25406110119931 1.58374008569191e-13 miRanda -0.214502668135583 0.00907143930411108 NA NA NA hsa-miR-183-5p EGR1 2.95681814393872 1.09965777344285e-92 -2.86869177371485 1.0832023819925e-54 miRTarBase -0.572115496113013 2.98432133060609e-48 NA NA NA hsa-miR-429 EGR1 2.84108892259147 3.88520896426515e-64 -2.86869177371485 1.0832023819925e-54 miRanda -0.44026978254159 1.2100273574456e-34 NA NA NA hsa-miR-590-3p EGR1 1.27438512890514 1.03164723481469e-23 -2.86869177371485 1.0832023819925e-54 miRanda -0.57738650434459 3.74594936368465e-28 NA NA NA hsa-miR-28-5p EIF2AK1 -0.14267073663385 0.0497619246260571 0.859351234809848 8.38838356282298e-53 miRanda -0.143546463072448 4.26354140335158e-07 NA NA NA hsa-miR-21-5p EIF4A2 2.32007501846389 3.08394781855554e-137 -0.458685981744615 6.79854430864405e-14 miRTarBase -0.220040692361575 2.91919563506492e-32 NA NA NA hsa-miR-28-5p EIF4E3 -0.14267073663385 0.0497619246260571 -1.14472452087938 6.75636040536301e-35 miRanda -0.204829970524929 8.50373422668106e-06 NA NA NA hsa-miR-338-3p ELF5 0.0799903526884966 0.575137668326679 -2.82341247511366 1.99900769985845e-12 miRanda -0.469319488708656 1.47634542779879e-06 NA NA NA hsa-miR-28-5p ELMOD3 -0.14267073663385 0.0497619246260571 -1.18321142026853 1.42445980731353e-54 miRanda -0.129213859015614 0.000848520939567749 NA NA NA hsa-miR-28-5p ENOSF1 -0.14267073663385 0.0497619246260571 -0.0494377033754967 0.530975780572447 miRanda -0.116679544081481 0.00185633881646488 NA NA NA hsa-miR-28-5p ENPP5 -0.14267073663385 0.0497619246260571 0.730179563987445 0.000250569116717678 miRanda -0.430134462533778 5.87774849114148e-06 NA NA NA hsa-miR-28-5p EPB41L4A -0.14267073663385 0.0497619246260571 -0.674310150249758 9.72635451687197e-08 miRanda -0.387849374944374 1.07747570210006e-10 NA NA NA hsa-miR-28-5p EPM2AIP1 -0.14267073663385 0.0497619246260571 -0.437165458818003 3.86366376911147e-08 miRanda -0.144548878665864 0.000146275825401192 NA NA NA hsa-miR-28-5p EPN1 -0.14267073663385 0.0497619246260571 0.758288535610807 2.09677654098872e-20 miRanda -0.122761755854016 0.00209899863394848 NA NA NA hsa-miR-28-5p EPN2 -0.14267073663385 0.0497619246260571 -0.0264754384448693 0.695378898008471 miRanda -0.161848837849795 4.07182269870998e-07 NA NA NA hsa-miR-28-5p ERAL1 -0.14267073663385 0.0497619246260571 0.598584957474529 1.72513784158031e-17 miRanda -0.125046069253116 0.000243068164108692 NA NA NA hsa-miR-28-5p ERGIC1 -0.14267073663385 0.0497619246260571 0.646215620956665 8.40261132551627e-14 miRanda -0.421087236029744 3.74633309969529e-25 NA NA NA hsa-miR-28-5p ERI2 -0.14267073663385 0.0497619246260571 0.367887024257485 6.00654283242427e-06 miRanda -0.26523497387734 5.06048254756163e-12 NA NA NA hsa-miR-28-5p ERLIN2 -0.14267073663385 0.0497619246260571 0.0041901531172277 0.969544348188735 miRanda -0.253389185184216 1.08006189075056e-06 NA NA NA hsa-miR-20b-5p ESR1 0.78236583455125 8.7938334801223e-05 0.349232651607838 0.313942462521254 miRTarBase -0.145222488631583 0.0144616347030701 NA NA NA hsa-miR-200b-3p ETS1 2.11744072703209 1.66710572104191e-43 -0.979239394867202 3.4732433286646e-20 miRTarBase -0.246496070854348 2.76376768290262e-28 NA NA NA hsa-miR-28-5p EXOC6 -0.14267073663385 0.0497619246260571 0.307205555860763 0.000882348548359484 miRanda -0.330426623232935 2.76721875618044e-14 NA NA NA hsa-miR-107 EZH1 0.678998026350662 2.56224148930538e-16 -1.35637018200037 1.55326690177115e-74 miRanda -0.125120221047238 0.000169146190224106 NA NA NA hsa-miR-28-5p F2RL2 -0.14267073663385 0.0497619246260571 1.83288694519631 1.27552904921777e-14 miRanda -0.456824867145525 7.02447930509342e-05 NA NA NA hsa-miR-320b F3 0.412787504747938 0.00113457276903985 -2.18337486686632 5.89270776390065e-40 miRanda -0.272475802639654 5.61766395253478e-09 NA NA NA hsa-miR-590-3p F3 1.27438512890514 1.03164723481469e-23 -2.18337486686632 5.89270776390065e-40 miRanda -0.341030258962204 4.25745086421092e-13 NA NA NA hsa-miR-590-3p FABP4 1.27438512890514 1.03164723481469e-23 -6.24132062791966 5.1974657436935e-60 miRanda -1.02870878680962 1.52445864487531e-20 NA NA NA hsa-miR-28-5p FAHD1 -0.14267073663385 0.0497619246260571 0.778155825824243 6.70403995205136e-28 miRanda -0.253441421631961 2.04651536156701e-13 NA NA NA hsa-miR-107 FAM107A 0.678998026350662 2.56224148930538e-16 -3.7437044389083 2.37244574734405e-64 miRanda -0.426091625514007 1.30379019629043e-05 NA NA NA hsa-miR-342-3p FAM107A 1.21944481975657 6.81914373001202e-19 -3.7437044389083 2.37244574734405e-64 miRanda -0.501445215232902 2.54163316810432e-18 NA NA NA hsa-miR-590-5p FAM107A 0.746515607868274 8.51300479640125e-09 -3.7437044389083 2.37244574734405e-64 miRanda -0.198157017683607 0.00164499358632 NA NA NA hsa-miR-28-5p FAM110B -0.14267073663385 0.0497619246260571 0.446891190279147 0.00220027405081027 miRanda -0.438812554775886 2.00385789711424e-10 NA NA NA hsa-miR-28-5p FAM134C -0.14267073663385 0.0497619246260571 0.222345364858138 0.000232535871253503 miRanda -0.179678608103432 2.9924102541235e-10 NA NA NA hsa-miR-375 FAM135A 2.09893673049766 1.68351780396203e-16 -1.25723792576387 7.59505292047769e-25 miRanda -0.138175264028737 2.19193707391442e-17 NA NA NA hsa-miR-28-5p FAM135B -0.14267073663385 0.0497619246260571 0.297929137431374 0.2926521551134 miRanda -0.639664644933673 1.88481695577419e-06 NA NA NA hsa-miR-429 FAM13A 2.84108892259147 3.88520896426515e-64 -2.57201735378438 3.81293606408784e-108 miRanda -0.311050493324474 5.11907978826639e-38 NA NA NA hsa-miR-28-5p FAM151B -0.14267073663385 0.0497619246260571 0.353772763587107 0.000222374712049446 miRanda -0.356303249159723 2.48752766078358e-15 NA NA NA hsa-miR-28-5p FAM160A2 -0.14267073663385 0.0497619246260571 -0.147263090451403 0.00579602030005972 miRanda -0.120301491046325 1.91930813386215e-06 NA NA NA hsa-miR-28-5p FAM169A -0.14267073663385 0.0497619246260571 0.000732433647964825 0.996131193444778 miRanda -0.173595504883953 0.0158016800253962 NA NA NA hsa-miR-375 FAM180A 2.09893673049766 1.68351780396203e-16 -1.54070778927332 1.44433264843771e-19 miRanda -0.1340937903857 4.0855369206658e-09 NA NA NA hsa-miR-28-5p FANK1 -0.14267073663385 0.0497619246260571 0.727752467493866 5.08127758503224e-06 miRanda -0.326148845787742 1.8492440727162e-05 NA NA NA hsa-miR-28-5p FBXW4 -0.14267073663385 0.0497619246260571 -0.0900849463685356 0.206348671758354 miRanda -0.152099944153854 6.63763082332348e-06 NA NA NA hsa-miR-28-5p FCGRT -0.14267073663385 0.0497619246260571 -0.474452179789248 1.11132066883725e-05 miRanda -0.234186660196465 5.33644165622309e-06 NA NA NA hsa-miR-28-5p FCHO2 -0.14267073663385 0.0497619246260571 -0.606061420659775 1.08535609457921e-15 miRanda -0.141100901822869 0.000112527994366655 NA NA NA hsa-miR-375 FCRL3 2.09893673049766 1.68351780396203e-16 0.799879914744875 0.003851675610683 miRanda -0.150043476300105 3.89290902342124e-05 NA NA NA hsa-miR-28-5p FEM1C -0.14267073663385 0.0497619246260571 -0.260293397561805 0.000498044801322955 miRanda -0.176460573027483 6.55806438951583e-07 NA NA NA hsa-miR-15a-5p FGF7 0.812445324157528 4.50263417099822e-20 -2.04584639946267 6.89325129361849e-43 miRTarBase -0.531335245933583 1.07978052597967e-19 NA NA NA hsa-miR-107 FGFR2 0.678998026350662 2.56224148930538e-16 -0.775141603791194 2.04453402884716e-05 miRanda -0.355887284370132 1.72803357435902e-06 NA NA NA hsa-miR-193a-3p FGFR2 0.310617999804917 0.00477640270974957 -0.775141603791194 2.04453402884716e-05 miRanda -0.294573603452518 2.04016256999751e-07 NA NA NA hsa-miR-324-5p FGFR2 0.211552647440779 0.139408130311654 -0.775141603791194 2.04453402884716e-05 miRanda -0.110327134471757 0.0118535869870796 NA NA NA hsa-miR-330-5p FGFR2 0.626063225953928 3.42215028606779e-09 -0.775141603791194 2.04453402884716e-05 miRanda -0.132979535710109 0.0238532881388265 NA NA NA hsa-miR-590-3p FGFR2 1.27438512890514 1.03164723481469e-23 -0.775141603791194 2.04453402884716e-05 miRanda -0.203907123628065 4.71460047941147e-05 NA NA NA hsa-miR-146b-5p FHL1 0.631041661167954 6.20366593452965e-08 -4.39641190571109 2.95720924032036e-115 miRanda -0.237312054925811 0.000264368860560791 NA NA NA hsa-miR-193a-3p FHL1 0.310617999804917 0.00477640270974957 -4.39641190571109 2.95720924032036e-115 miRanda -0.31853323287849 4.1812749430564e-06 NA NA NA hsa-miR-429 FHL1 2.84108892259147 3.88520896426515e-64 -4.39641190571109 2.95720924032036e-115 miRanda -0.701131105430921 2.80962444317132e-74 NA NA NA hsa-miR-455-5p FHL1 0.284641224662773 0.0357572339594277 -4.39641190571109 2.95720924032036e-115 miRanda -0.133082049662736 0.0183943532964323 NA NA NA hsa-miR-590-3p FHL1 1.27438512890514 1.03164723481469e-23 -4.39641190571109 2.95720924032036e-115 miRanda -0.635695715083533 8.84521198864127e-27 NA NA NA hsa-miR-484 FIS1 0.349444060004737 0.00154491249625173 0.251716891563224 0.00229851286504775 miRTarBase -0.106007860743033 3.50557200623781e-05 NA NA NA hsa-miR-125a-3p FKBP5 -0.176412960953959 0.10108079286419 -0.910640773205637 6.12828690619755e-09 miRanda -0.152167707336506 0.00264783241612225 NA NA NA hsa-miR-342-3p FKBP5 1.21944481975657 6.81914373001202e-19 -0.910640773205637 6.12828690619755e-09 miRanda -0.180417784899073 2.72482727577721e-06 NA NA NA hsa-miR-28-5p FKTN -0.14267073663385 0.0497619246260571 0.0913291179055893 0.215754519232549 miRanda -0.144817438914449 3.46968527462469e-05 NA NA NA hsa-miR-200b-3p FLT1 2.11744072703209 1.66710572104191e-43 -0.976682151789582 4.79604479745106e-23 miRTarBase -0.237387253520266 3.06104626134544e-30 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-28-5p FLYWCH1 -0.14267073663385 0.0497619246260571 0.12389624476354 0.117705319180408 miRanda -0.229517717967346 7.89386614037077e-10 NA NA NA hsa-miR-590-3p FMO2 1.27438512890514 1.03164723481469e-23 -4.4404087637002 7.91152237376595e-70 miRanda -0.406603250666587 5.95163763153721e-08 NA NA NA hsa-miR-21-5p FMOD 2.32007501846389 3.08394781855554e-137 -1.5830220066125 1.49258819797672e-21 miRTarBase -0.391125968145743 7.97182814844372e-14 23445447;19906824 Our method exhibits ultrahigh sensitivity toward miR-21 with detection limits of 10 fM at 37 °C and 1 aM at 4 °C which corresponds to nine strands of miR-21 in a 15 μL sample and it is capable of distinguishing among miRNA family members;Gain-of miR-21 function in MSMC and LSMC reduced TGF-beta-induced expression of fibromodulin and TGF-beta-induced factor P < 0.05 and moderately altered the rate of cell growth and caspase-3/7 activity in these cells ; breast cancer;sarcoma hsa-miR-181a-5p FOS 0.635863607630183 6.72486918157744e-11 -2.7451718741702 2.64568082199498e-43 miRTarBase -0.410948031055006 1.7230387501528e-08 NA NA NA hsa-miR-590-3p FOS 1.27438512890514 1.03164723481469e-23 -2.7451718741702 2.64568082199498e-43 miRanda -0.566395526805679 6.60790668638515e-24 NA NA NA hsa-miR-330-5p FOSB 0.626063225953928 3.42215028606779e-09 -4.06652116561399 3.3514379192218e-56 miRanda -0.680496825489185 7.83327779134597e-15 NA NA NA hsa-miR-342-3p FOSB 1.21944481975657 6.81914373001202e-19 -4.06652116561399 3.3514379192218e-56 miRanda -0.314630359172702 2.91259905371314e-06 NA NA NA hsa-miR-375 FOXC1 2.09893673049766 1.68351780396203e-16 -1.56967295609977 3.50287816253511e-14 miRanda -0.392339462923658 3.22168211235317e-51 NA NA NA hsa-miR-183-5p FOXO1 2.95681814393872 1.09965777344285e-92 -1.98726551876693 3.0579805549685e-75 miRTarBase -0.397042214565454 3.35421059028432e-66 25813403;25983004 Knockdown of CTNNB1 also showed concordant down-regulations of miR-183 -96 and -182 and the re-expression of FOXO1;MiR 183 promotes growth of non small cell lung cancer cells through FoxO1 inhibition; Here we analyzed the regulation of FoxO1 by miR-183 in vitro using luciferase-reporter assay; Moreover miR-183 bound to FoxO1 mRNA to prevent its translation through its 3'untranslated region UTR; Furthermore administration of miR-183 suppressed FoxO1 levels in NSCLC resulting in a significant increase in NSCLC growth in vitro and in vivo while administration of antisense of miR-183 significantly increased FoxO1 levels in NSCLC resulting in a significant decrease in NSCLC growth ; liver cancer;lung squamous cell cancer hsa-miR-375 FOXP2 2.09893673049766 1.68351780396203e-16 -3.10671503377831 7.7457852611569e-43 miRanda -0.223016255363538 7.68269188732194e-13 NA NA NA hsa-miR-375 FPR2 2.09893673049766 1.68351780396203e-16 -0.195181879965793 0.38084203077084 miRanda -0.255000934811514 7.51133227235782e-19 NA NA NA hsa-miR-28-5p FUT8 -0.14267073663385 0.0497619246260571 0.726014580237623 6.08952916861957e-11 miRanda -0.425606323456591 5.65560664857273e-16 NA NA NA hsa-miR-193a-3p GABRP 0.310617999804917 0.00477640270974957 -3.35936906616086 1.69813865017762e-15 miRanda -0.519491906136129 0.000102477154856306 NA NA NA hsa-miR-28-5p GALNT10 -0.14267073663385 0.0497619246260571 0.227833941975381 0.0563309072028891 miRanda -0.324201567304107 9.22307992385576e-09 NA NA NA hsa-miR-28-5p GALNT6 -0.14267073663385 0.0497619246260571 1.53253468503729 1.95615996419132e-15 miRanda -0.690592453180032 6.97388105280589e-14 NA NA NA hsa-miR-375 GAP43 2.09893673049766 1.68351780396203e-16 -0.252869077259157 0.152628613137104 miRanda -0.127967453314962 3.27677582590075e-08 NA NA NA hsa-miR-375 GATA6 2.09893673049766 1.68351780396203e-16 -0.699851594860171 1.92456260924552e-07 miRanda -0.165989908192913 1.6229185846306e-21 NA NA NA hsa-miR-28-5p GATAD1 -0.14267073663385 0.0497619246260571 -0.118787232382459 0.0381461411955589 miRanda -0.220960335790874 1.44173216936157e-16 NA NA NA hsa-miR-28-5p GATM -0.14267073663385 0.0497619246260571 -0.791153922275685 1.74092462595563e-07 miRanda -0.205174678583206 0.00473288183325133 NA NA NA hsa-miR-28-5p GCM1 -0.14267073663385 0.0497619246260571 0.360191323603245 0.134565410281452 miRanda -0.488569605079757 1.91929018001998e-05 NA NA NA hsa-miR-142-3p GHR 1.53951237846104 2.06769936282034e-17 -3.36237154973502 5.01584120795748e-76 miRanda -0.258278368150427 1.97065873638164e-12 NA NA NA hsa-miR-429 GHR 2.84108892259147 3.88520896426515e-64 -3.36237154973502 5.01584120795748e-76 miRanda -0.565426163436487 1.88289719909835e-57 NA NA NA hsa-miR-455-5p GHR 0.284641224662773 0.0357572339594277 -3.36237154973502 5.01584120795748e-76 miRanda -0.358213904373597 9.36049755011874e-13 NA NA NA hsa-miR-28-5p GIPR -0.14267073663385 0.0497619246260571 0.017258044160555 0.935509804568678 miRanda -0.685109906674805 8.75524546773542e-12 NA NA NA hsa-miR-28-5p GKAP1 -0.14267073663385 0.0497619246260571 -0.51386963839469 2.55435086487334e-08 miRanda -0.154887800263099 0.000460548342740559 NA NA NA hsa-miR-28-5p GOSR1 -0.14267073663385 0.0497619246260571 0.030365365851841 0.621004932234963 miRanda -0.101953135923577 0.000463895107781679 NA NA NA hsa-miR-28-5p GPBP1 -0.14267073663385 0.0497619246260571 -0.0137041815437682 0.770311932798486 miRanda -0.127042004309214 8.6747456269106e-09 NA NA NA hsa-miR-28-5p GPD2 -0.14267073663385 0.0497619246260571 0.210900888733789 0.0264157292786502 miRanda -0.129869118527292 0.00409414238800342 NA NA NA hsa-miR-338-3p GPM6B 0.0799903526884966 0.575137668326679 -2.23343254430802 1.51570824751064e-39 miRanda -0.224149685209491 1.48068312393091e-07 NA NA NA hsa-miR-375 GPM6B 2.09893673049766 1.68351780396203e-16 -2.23343254430802 1.51570824751064e-39 miRanda -0.270095516956685 6.9963402906846e-33 NA NA NA hsa-miR-375 GPR146 2.09893673049766 1.68351780396203e-16 -2.68788146464682 1.82253967407916e-104 miRanda -0.126629253584628 6.15205091660366e-12 NA NA NA hsa-miR-193a-3p GPX3 0.310617999804917 0.00477640270974957 -3.53021228868393 1.43552749335212e-79 miRanda -0.176708486870467 0.00614748811151321 NA NA NA hsa-miR-324-5p GPX3 0.211552647440779 0.139408130311654 -3.53021228868393 1.43552749335212e-79 miRanda -0.179296991107351 0.000291193265623536 NA NA NA hsa-miR-28-5p GRAMD1A -0.14267073663385 0.0497619246260571 1.10999274616443 2.6714856402589e-53 miRanda -0.111835566009971 0.00232890461745794 NA NA NA hsa-miR-375 GRAMD1B 2.09893673049766 1.68351780396203e-16 -0.188151997374813 0.241605807391635 miRanda -0.126959955721634 1.49789234449411e-09 NA NA NA hsa-miR-28-5p GRAMD1C -0.14267073663385 0.0497619246260571 -0.696224877463089 2.42950429103508e-08 miRanda -0.175710217376617 0.00336197515953319 NA NA NA hsa-miR-590-3p GRAMD3 1.27438512890514 1.03164723481469e-23 -1.31668353228658 1.2478558736513e-38 miRanda -0.134817381167101 3.55207019084658e-06 NA NA NA hsa-miR-107 GREM2 0.678998026350662 2.56224148930538e-16 -2.65211306689938 8.60704393228989e-30 miRanda -0.775941249137575 1.90771342749935e-15 NA NA NA hsa-miR-338-3p GREM2 0.0799903526884966 0.575137668326679 -2.65211306689938 8.60704393228989e-30 miRanda -0.313477765426399 6.57565072883759e-08 NA NA NA hsa-miR-375 GREM2 2.09893673049766 1.68351780396203e-16 -2.65211306689938 8.60704393228989e-30 miRanda -0.149955937442218 2.54774633920013e-06 NA NA NA hsa-miR-28-5p GRIA2 -0.14267073663385 0.0497619246260571 -1.22821710537384 0.00759618405734023 miRanda -0.972213489728838 8.80044759415615e-06 NA NA NA hsa-miR-375 GRIA4 2.09893673049766 1.68351780396203e-16 -4.77196655087619 1.17769710567523e-48 miRanda -0.136966555233605 0.00269322084357658 NA NA NA hsa-miR-429 GSN 2.84108892259147 3.88520896426515e-64 -2.23393150379953 1.72954577951929e-91 miRanda -0.325595839117764 1.91505728889962e-49 NA NA NA hsa-miR-28-5p GSTCD -0.14267073663385 0.0497619246260571 0.519181234576788 2.42559606422446e-07 miRanda -0.273053868148414 1.15459678054143e-08 NA NA NA hsa-miR-28-5p GSTT2 -0.14267073663385 0.0497619246260571 -0.191330811443633 0.355850883029681 miRanda -0.220314719845183 0.0256737201615651 NA NA NA hsa-miR-193a-3p GULP1 0.310617999804917 0.00477640270974957 -1.94467535837848 1.33674495102449e-37 miRanda -0.258415740409042 1.60406242278695e-07 NA NA NA hsa-miR-429 GULP1 2.84108892259147 3.88520896426515e-64 -1.94467535837848 1.33674495102449e-37 miRanda -0.333941665260397 1.36657577327322e-30 NA NA NA hsa-miR-455-5p GULP1 0.284641224662773 0.0357572339594277 -1.94467535837848 1.33674495102449e-37 miRanda -0.107284069736114 0.00772685989898407 NA NA NA hsa-miR-590-3p GULP1 1.27438512890514 1.03164723481469e-23 -1.94467535837848 1.33674495102449e-37 miRanda -0.346284930095145 7.76564810978343e-16 NA NA NA hsa-miR-146b-5p GYG2 0.631041661167954 6.20366593452965e-08 -3.51302071594925 7.99133789913513e-74 miRanda -0.129824226136289 0.0367123322578226 NA NA NA hsa-miR-375 HAS3 2.09893673049766 1.68351780396203e-16 -3.33737363445779 1.70838289491702e-69 miRanda -0.185665653321465 5.77587244310212e-12 NA NA NA hsa-miR-28-5p HHAT -0.14267073663385 0.0497619246260571 0.644196417869949 1.52387006114795e-08 miRanda -0.377612142840797 2.72687205190048e-12 NA NA NA hsa-miR-28-5p HK2 -0.14267073663385 0.0497619246260571 -0.0567451434395441 0.607921539997626 miRanda -0.2522359977272 1.46926915548621e-06 NA NA NA hsa-miR-375 HLA-F 2.09893673049766 1.68351780396203e-16 0.498132115610089 0.00038064325918255 miRanda -0.127331355925977 3.6563550953033e-12 NA NA NA hsa-miR-429 HLF 2.84108892259147 3.88520896426515e-64 -3.73360626511854 1.05238992329545e-69 miRanda -0.48361445321537 2.30975623056168e-30 NA NA NA hsa-miR-590-3p HLF 1.27438512890514 1.03164723481469e-23 -3.73360626511854 1.05238992329545e-69 miRanda -0.553985857131489 5.28255026776511e-19 NA NA NA hsa-miR-28-5p HMGCL -0.14267073663385 0.0497619246260571 0.119677157715048 0.0987034936096925 miRanda -0.186094982487334 5.51594548336389e-08 NA NA NA hsa-miR-375 HOXA3 2.09893673049766 1.68351780396203e-16 -2.36187003963078 4.27498676842218e-42 miRanda -0.21571146713758 6.8368847728706e-20 NA NA NA hsa-miR-19a-3p HOXA5 0.817507952171848 3.76285090469625e-08 -3.01456089936248 1.31977175737153e-66 miRTarBase -0.272384019281586 2.76029902240404e-10 NA NA NA hsa-miR-429 HOXA5 2.84108892259147 3.88520896426515e-64 -3.01456089936248 1.31977175737153e-66 miRanda -0.451062661519865 2.22273881094804e-39 NA NA NA hsa-miR-338-3p HOXA7 0.0799903526884966 0.575137668326679 -2.66233366186079 6.15928913475097e-51 miRanda -0.170677414948889 0.000171275044417347 NA NA NA hsa-miR-339-5p HOXA7 -0.211548290465418 0.0685885445822389 -2.66233366186079 6.15928913475097e-51 miRanda -0.245246567929761 1.09069980219044e-05 NA NA NA hsa-miR-375 HOXA7 2.09893673049766 1.68351780396203e-16 -2.66233366186079 6.15928913475097e-51 miRanda -0.17298698456486 2.21837226875451e-12 NA NA NA hsa-miR-142-3p HOXA9 1.53951237846104 2.06769936282034e-17 -2.51701243665575 2.02680334794481e-43 miRanda -0.131408549736422 0.000219905120561761 NA NA NA hsa-miR-210-3p HOXA9 2.38367203491819 3.73261999106754e-22 -2.51701243665575 2.02680334794481e-43 miRTarBase -0.20856023851932 3.71161302588325e-16 NA NA NA hsa-miR-324-5p HOXA9 0.211552647440779 0.139408130311654 -2.51701243665575 2.02680334794481e-43 miRanda -0.195880828915595 2.04520098733441e-05 NA NA NA hsa-miR-342-3p HOXA9 1.21944481975657 6.81914373001202e-19 -2.51701243665575 2.02680334794481e-43 miRanda -0.268889558298345 8.26970547065818e-09 NA NA NA hsa-miR-590-3p HOXA9 1.27438512890514 1.03164723481469e-23 -2.51701243665575 2.02680334794481e-43 miRanda -0.39834605077735 2.05929833568387e-14 NA NA NA hsa-miR-28-5p HOXB3 -0.14267073663385 0.0497619246260571 -0.0860590412997158 0.642417857654296 miRanda -0.475202338351595 5.93635891671727e-08 NA NA NA hsa-miR-375 HPDL 2.09893673049766 1.68351780396203e-16 0.970313379779714 1.73895017429189e-05 miRanda -0.25897928289724 1.02517702938508e-18 NA NA NA hsa-miR-125a-3p HPGD -0.176412960953959 0.10108079286419 -1.62713559028413 1.6727043733474e-09 miRanda -0.278274291940041 0.00143621016480484 NA NA NA hsa-miR-320b HPGD 0.412787504747938 0.00113457276903985 -1.62713559028413 1.6727043733474e-09 miRanda -0.439199524226785 2.24721396119039e-09 NA NA NA hsa-miR-590-3p HPGD 1.27438512890514 1.03164723481469e-23 -1.62713559028413 1.6727043733474e-09 miRanda -0.424886310925188 1.12765336304815e-08 NA NA NA hsa-miR-590-5p HPGD 0.746515607868274 8.51300479640125e-09 -1.62713559028413 1.6727043733474e-09 miRanda -0.423017866824906 2.61420105814369e-09 NA NA NA hsa-miR-590-5p HPSE2 0.746515607868274 8.51300479640125e-09 -4.96456425679755 2.39838371300025e-73 miRanda -0.442550791788817 1.68691979418526e-08 NA NA NA hsa-miR-375 HSD17B13 2.09893673049766 1.68351780396203e-16 -5.42193557571211 3.45339215058616e-118 miRanda -0.265248259216041 6.72111429659138e-14 NA NA NA hsa-miR-28-5p IER3 -0.14267073663385 0.0497619246260571 1.45642417730307 4.17853765486836e-24 miRanda -0.445532576838926 1.77892706208939e-10 NA NA NA hsa-miR-142-3p IGF1 1.53951237846104 2.06769936282034e-17 -2.74966407318656 1.16668946763881e-41 miRanda -0.123324920262687 0.00187203848886841 NA NA NA hsa-miR-27a-3p IGF1 0.388496361379095 1.42373532086331e-05 -2.74966407318656 1.16668946763881e-41 miRTarBase -0.544265988607736 2.14223289540701e-11 NA NA NA hsa-miR-590-3p IGF1 1.27438512890514 1.03164723481469e-23 -2.74966407318656 1.16668946763881e-41 miRanda -0.58985675364928 6.40681378251621e-25 NA NA NA hsa-miR-375 IGF2BP2 2.09893673049766 1.68351780396203e-16 -2.09056613546731 8.03883357755438e-21 miRanda -0.398516176705958 4.44746556432504e-44 NA NA NA hsa-miR-28-5p IKBKAP -0.14267073663385 0.0497619246260571 0.0789492756746029 0.15612858735694 miRanda -0.118612871400018 6.65742475118864e-06 NA NA NA hsa-miR-28-5p IKBKB -0.14267073663385 0.0497619246260571 0.273066826249678 0.00234033685126725 miRanda -0.249159305195741 4.36298401628208e-09 NA NA NA hsa-miR-155-5p IL13RA1 1.09766314984151 4.55650930885814e-15 0.0785365367680315 0.282318167449858 miRTarBase -0.100903915758177 7.01157648150312e-09 NA NA NA hsa-miR-28-5p IL13RA1 -0.14267073663385 0.0497619246260571 0.0785365367680315 0.282318167449858 miRanda -0.146588109721817 2.29274382682583e-05 NA NA NA hsa-miR-375 IL1RAP 2.09893673049766 1.68351780396203e-16 -0.759572369248282 5.03872337590099e-11 miRanda -0.111918762451102 1.90407427894537e-13 NA NA NA hsa-miR-375 IL2RA 2.09893673049766 1.68351780396203e-16 0.552215139772291 0.00781659262634694 miRanda -0.226533685168416 3.8944695458836e-17 NA NA NA hsa-miR-28-5p IMPDH1 -0.14267073663385 0.0497619246260571 0.896084693787804 4.77040402047121e-25 miRanda -0.101168477468638 0.0174266284653124 NA NA NA hsa-miR-28-5p INPP5J -0.14267073663385 0.0497619246260571 0.586361668320023 0.00503623021199427 miRanda -0.777616097841152 2.31907281894163e-15 NA NA NA hsa-miR-28-5p IQSEC2 -0.14267073663385 0.0497619246260571 0.43925999202862 1.87323493794481e-07 miRanda -0.168166530507332 2.97911256467842e-05 NA NA NA hsa-miR-148a-3p IRS1 0.706969798912638 5.52538085480485e-09 -1.09359999788168 5.90327201022502e-13 miRTarBase -0.30022382292007 2.08482327044964e-12 NA NA NA hsa-miR-375 IRX6 2.09893673049766 1.68351780396203e-16 -3.40348661387814 5.19317395535841e-39 miRanda -0.418916033296392 1.21922329078054e-33 NA NA NA hsa-miR-21-5p ISCU 2.32007501846389 3.08394781855554e-137 -0.474318624658276 2.67102425402634e-20 miRTarBase -0.14822383985227 1.75986348300615e-20 NA NA NA hsa-miR-28-5p ISCU -0.14267073663385 0.0497619246260571 -0.474318624658276 2.67102425402634e-20 miRanda -0.115854970892749 3.22684462403418e-06 NA NA NA hsa-miR-28-5p ITGA3 -0.14267073663385 0.0497619246260571 -0.299252352501844 0.0107499356635658 miRanda -0.36126889309902 6.72512700126372e-11 NA NA NA hsa-miR-330-5p ITGA7 0.626063225953928 3.42215028606779e-09 -3.42938571679422 4.12756715511965e-78 miRanda -0.645663755348389 1.98188299206038e-24 NA NA NA hsa-miR-339-5p ITGA7 -0.211548290465418 0.0685885445822389 -3.42938571679422 4.12756715511965e-78 miRanda -0.154798310368845 0.00974568162043182 NA NA NA hsa-miR-107 ITM2A 0.678998026350662 2.56224148930538e-16 -2.75204265899877 9.55524540055346e-61 miRanda -0.469616336979226 1.39121664984151e-10 NA NA NA hsa-miR-125a-3p ITM2A -0.176412960953959 0.10108079286419 -2.75204265899877 9.55524540055346e-61 miRanda -0.121498771400719 0.0360786850131136 NA NA NA hsa-miR-375 ITM2A 2.09893673049766 1.68351780396203e-16 -2.75204265899877 9.55524540055346e-61 miRanda -0.166828706307385 1.38483195233048e-12 NA NA NA hsa-miR-429 ITM2A 2.84108892259147 3.88520896426515e-64 -2.75204265899877 9.55524540055346e-61 miRanda -0.448077302083026 2.57573306139109e-43 NA NA NA hsa-miR-590-3p ITM2A 1.27438512890514 1.03164723481469e-23 -2.75204265899877 9.55524540055346e-61 miRanda -0.376992731559983 1.3124117067755e-14 NA NA NA hsa-miR-590-5p ITM2A 0.746515607868274 8.51300479640125e-09 -2.75204265899877 9.55524540055346e-61 miRanda -0.369221920291944 2.71559828742973e-15 NA NA NA hsa-miR-28-5p IVD -0.14267073663385 0.0497619246260571 -0.0240972756498818 0.810416205879283 miRanda -0.461574514514484 3.38114554736114e-23 NA NA NA hsa-miR-21-5p JAG1 2.32007501846389 3.08394781855554e-137 -0.639848689982383 1.267264807356e-11 miRTarBase -0.129114979011453 1.3818320929806e-05 NA NA NA hsa-miR-28-5p JKAMP -0.14267073663385 0.0497619246260571 0.0735788909422048 0.22789285081931 miRanda -0.24997489116713 1.33099887959275e-18 NA NA NA hsa-miR-28-5p JPH3 -0.14267073663385 0.0497619246260571 1.09335026757806 1.5377591231963e-07 miRanda -0.259615856533199 0.00943315433708511 NA NA NA hsa-miR-155-5p JUN 1.09766314984151 4.55650930885814e-15 -1.36309173493779 4.05020743854001e-29 miRTarBase -0.151050894850655 5.76726631886013e-07 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-miR-375 KALRN 2.09893673049766 1.68351780396203e-16 -1.5107223055413 2.88107495352718e-31 miRanda -0.148727875355044 1.66710211320528e-17 NA NA NA hsa-miR-375 KCNB2 2.09893673049766 1.68351780396203e-16 -2.1690333507359 1.95717242383358e-20 miRanda -0.313361988769725 2.31732198979805e-24 NA NA NA hsa-miR-330-5p KCTD14 0.626063225953928 3.42215028606779e-09 -2.31508177102094 4.81393899543138e-30 miRanda -0.264285249579327 9.5299288907246e-05 NA NA NA hsa-miR-200b-3p KDR 2.11744072703209 1.66710572104191e-43 -1.26178488366313 1.81783097872036e-35 miRTarBase -0.262999260406618 3.87053169124588e-34 NA NA NA hsa-miR-375 KHDRBS3 2.09893673049766 1.68351780396203e-16 -0.535630864859294 7.93502963529463e-05 miRanda -0.163350499452152 1.33964757425306e-20 NA NA NA hsa-miR-28-5p KIAA0100 -0.14267073663385 0.0497619246260571 -0.0958458902820514 0.226748853303652 miRanda -0.103750602698321 0.00593347169014391 NA NA NA hsa-miR-28-5p KIAA0319L -0.14267073663385 0.0497619246260571 0.399937221728762 2.70410247773894e-07 miRanda -0.290985152725794 2.02934336200034e-15 NA NA NA hsa-miR-28-5p KIAA1328 -0.14267073663385 0.0497619246260571 -0.669584991112985 6.66171801821041e-21 miRanda -0.101475073882874 0.00354775169440602 NA NA NA hsa-miR-193a-3p KIT 0.310617999804917 0.00477640270974957 -3.55980779277124 2.17700605158782e-58 miRanda -0.423244385923827 9.1952492703228e-09 NA NA NA hsa-miR-338-3p KIT 0.0799903526884966 0.575137668326679 -3.55980779277124 2.17700605158782e-58 miRanda -0.311406099865202 4.36514658431642e-08 NA NA NA hsa-miR-342-3p KIT 1.21944481975657 6.81914373001202e-19 -3.55980779277124 2.17700605158782e-58 miRanda -0.435927652877587 2.76373234511638e-14 NA NA NA hsa-miR-590-3p KIT 1.27438512890514 1.03164723481469e-23 -3.55980779277124 2.17700605158782e-58 miRanda -0.400477071862 6.4525241042505e-10 NA NA NA hsa-miR-103a-3p KLF4 0.610673390034345 1.63113920514646e-12 -2.5658507723861 1.98241408884064e-67 miRTarBase -0.371567222081179 3.47255710214153e-09 NA NA NA hsa-miR-107 KLF4 0.678998026350662 2.56224148930538e-16 -2.5658507723861 1.98241408884064e-67 miRTarBase;miRanda -0.461879349672299 1.23107045223773e-12 NA NA NA hsa-miR-25-3p KLF4 -0.00546790775985073 0.944061771389468 -2.5658507723861 1.98241408884064e-67 miRTarBase -0.242539392329916 0.000690131538900923 NA NA NA hsa-miR-375 KLF4 2.09893673049766 1.68351780396203e-16 -2.5658507723861 1.98241408884064e-67 miRanda -0.107900770782367 3.2799038965094e-07 26224477 MiR 375 targets KLF4 and impacts the proliferation of colorectal carcinoma; Subsequently using the luciferase reporter assays we found that the KLF4 untranslated region 3'UTR carries the direct binding site of miR-375; Inhibition of KLF4 performed similar effects with miR-375 overexpression on CRC cells and overexpression of KLF4 could significantly reverse the tumor suppressive effects of miR-375 on CRC cells; Furthermore we found overexpressed miR-375 effectively repressed tumor growth via KLF4 in xenograft animal experiment; Taken together these results illustrated that miR-375 depresses proliferation of CRC through regulating 3'UTR of KLF4 mRNA which might be a promising therapeutic target for treating colorectal cancers colorectal cancer hsa-miR-429 KLF4 2.84108892259147 3.88520896426515e-64 -2.5658507723861 1.98241408884064e-67 miRanda -0.349728467927596 9.21186465368341e-33 NA NA NA hsa-miR-590-3p KLF4 1.27438512890514 1.03164723481469e-23 -2.5658507723861 1.98241408884064e-67 miRanda -0.413516145241073 1.03039670714e-21 NA NA NA hsa-miR-28-5p KRT1 -0.14267073663385 0.0497619246260571 -0.777638722715821 0.00784390063724915 miRanda -0.587015506653331 2.44860809440113e-05 NA NA NA hsa-miR-320b KRT14 0.412787504747938 0.00113457276903985 -3.56554712257106 9.37297453410012e-16 miRanda -0.343436271696303 0.00514768072379313 NA NA NA hsa-miR-590-3p KRT5 1.27438512890514 1.03164723481469e-23 -3.35032755294679 1.65689981066059e-15 miRanda -0.330554716155581 0.00498422891631746 NA NA NA hsa-miR-375 KYNU 2.09893673049766 1.68351780396203e-16 -0.0218856240929535 0.91726010798386 miRanda -0.140832743680793 3.40857686359514e-07 NA NA NA hsa-miR-28-5p L2HGDH -0.14267073663385 0.0497619246260571 0.278240981720089 0.00050935264456272 miRanda -0.151525232157627 6.96875931303208e-05 NA NA NA hsa-miR-146b-5p LAMA2 0.631041661167954 6.20366593452965e-08 -2.16756236589159 1.88679943487983e-31 miRanda -0.179973081651138 0.00143455201383938 NA NA NA hsa-miR-375 LAMA2 2.09893673049766 1.68351780396203e-16 -2.16756236589159 1.88679943487983e-31 miRanda -0.141366224796711 2.30583404419529e-08 NA NA NA hsa-miR-590-3p LAMA2 1.27438512890514 1.03164723481469e-23 -2.16756236589159 1.88679943487983e-31 miRanda -0.585831805457993 2.67005129674139e-30 NA NA NA hsa-miR-590-3p LAMA3 1.27438512890514 1.03164723481469e-23 -2.53251208906831 2.18425216006227e-32 miRanda -0.514039700190172 1.03861305236823e-17 NA NA NA hsa-miR-375 LAMC2 2.09893673049766 1.68351780396203e-16 -1.62034326586173 2.05014148904585e-12 miRanda -0.225853976513003 1.07683110051097e-13 NA NA NA hsa-miR-330-5p LAMC3 0.626063225953928 3.42215028606779e-09 -1.32002986076632 4.64847430467652e-10 miRanda -0.292950727962664 1.9970694272922e-05 NA NA NA hsa-miR-375 LAMP3 2.09893673049766 1.68351780396203e-16 1.21714296693577 1.90210421863729e-08 miRanda -0.183998028363862 1.1115415040475e-10 NA NA NA hsa-miR-375 LARP6 2.09893673049766 1.68351780396203e-16 -1.77743473863714 1.02889284986309e-47 miRanda -0.177222738985085 1.59815987434758e-26 NA NA NA hsa-miR-375 LBR 2.09893673049766 1.68351780396203e-16 -0.401779315698072 8.08554841411615e-05 miRanda -0.125225974367861 1.83380369000825e-21 NA NA NA hsa-miR-320b LDB2 0.412787504747938 0.00113457276903985 -2.24235549916864 1.49095364446973e-88 miRanda -0.221887021337959 5.09097620066861e-11 NA NA NA hsa-miR-590-3p LDB2 1.27438512890514 1.03164723481469e-23 -2.24235549916864 1.49095364446973e-88 miRanda -0.404831805514626 2.67408644675472e-34 NA NA NA hsa-miR-28-5p LDB3 -0.14267073663385 0.0497619246260571 -1.85025183125106 1.91109961605668e-38 miRanda -0.156357444186515 0.0284689138796435 NA NA NA hsa-miR-375 LDHB 2.09893673049766 1.68351780396203e-16 -1.52355626193472 1.5585374854613e-22 miRanda -0.253388433399967 5.87116849741788e-36 22752059 The restoration of miR-375 suppressed the expression of LDHB and AEG-1/MTDH; LDHB which is regulated by the tumor suppressive miR-375 may therefore act as an oncogene in ESCC esophageal cancer hsa-miR-330-5p LEP 0.626063225953928 3.42215028606779e-09 -7.67518473730639 1.72637364788671e-75 miRanda -1.06705544039043 2.55717831715332e-13 NA NA NA hsa-miR-342-3p LEP 1.21944481975657 6.81914373001202e-19 -7.67518473730639 1.72637364788671e-75 miRanda -0.709224674762855 1.79405802467657e-10 NA NA NA hsa-miR-107 LEPR 0.678998026350662 2.56224148930538e-16 -3.24143926522135 2.40158609979225e-92 miRanda -0.650199086919738 9.52631335835176e-20 NA NA NA hsa-miR-146b-5p LEPR 0.631041661167954 6.20366593452965e-08 -3.24143926522135 2.40158609979225e-92 miRanda -0.125423954509927 0.0165069762615241 NA NA NA hsa-miR-320b LEPR 0.412787504747938 0.00113457276903985 -3.24143926522135 2.40158609979225e-92 miRanda -0.252399046973792 1.69994535962238e-07 NA NA NA hsa-miR-330-5p LEPR 0.626063225953928 3.42215028606779e-09 -3.24143926522135 2.40158609979225e-92 miRanda -0.313008444073696 4.27687566027306e-08 NA NA NA hsa-miR-342-3p LEPR 1.21944481975657 6.81914373001202e-19 -3.24143926522135 2.40158609979225e-92 miRanda -0.314557046784269 2.8966503098295e-13 NA NA NA hsa-miR-429 LEPR 2.84108892259147 3.88520896426515e-64 -3.24143926522135 2.40158609979225e-92 miRanda -0.483071748248401 2.53285744438158e-52 NA NA NA hsa-miR-590-3p LEPR 1.27438512890514 1.03164723481469e-23 -3.24143926522135 2.40158609979225e-92 miRanda -0.514759602681661 2.80648471789456e-27 NA NA NA hsa-miR-590-5p LEPR 0.746515607868274 8.51300479640125e-09 -3.24143926522135 2.40158609979225e-92 miRanda -0.424366188634251 2.28561711324811e-20 NA NA NA hsa-miR-375 LGR5 2.09893673049766 1.68351780396203e-16 -0.973708966607494 0.00028496921350823 miRanda -0.213386920777125 1.35367541756069e-09 NA NA NA hsa-miR-107 LHFP 0.678998026350662 2.56224148930538e-16 -2.16259674677525 1.67757586200326e-80 miRanda -0.460588150348164 6.16562438674738e-20 NA NA NA hsa-miR-146b-5p LHFP 0.631041661167954 6.20366593452965e-08 -2.16259674677525 1.67757586200326e-80 miRanda -0.12609617840932 0.000613717861350513 NA NA NA hsa-miR-429 LHFP 2.84108892259147 3.88520896426515e-64 -2.16259674677525 1.67757586200326e-80 miRanda -0.385142985685175 2.60131788225477e-69 NA NA NA hsa-miR-590-3p LHFP 1.27438512890514 1.03164723481469e-23 -2.16259674677525 1.67757586200326e-80 miRanda -0.441283658459807 6.45480009648945e-41 NA NA NA hsa-miR-590-5p LHFP 0.746515607868274 8.51300479640125e-09 -2.16259674677525 1.67757586200326e-80 miRanda -0.382535656080288 2.44782954661492e-33 NA NA NA hsa-miR-320b LIFR 0.412787504747938 0.00113457276903985 -3.04175429528162 6.69458064740976e-81 miRanda -0.199605935938188 3.09895121067652e-05 NA NA NA hsa-miR-429 LIFR 2.84108892259147 3.88520896426515e-64 -3.04175429528162 6.69458064740976e-81 miRanda -0.419771299608504 1.90312382606979e-39 NA NA NA hsa-miR-590-3p LIFR 1.27438512890514 1.03164723481469e-23 -3.04175429528162 6.69458064740976e-81 miRanda -0.437160363263133 3.72866531148678e-20 NA NA NA hsa-miR-429 LIPE 2.84108892259147 3.88520896426515e-64 -4.2711618761235 5.59802219281331e-80 miRanda -0.589555791847115 4.6557200927609e-39 NA NA NA hsa-miR-590-3p LIPE 1.27438512890514 1.03164723481469e-23 -4.2711618761235 5.59802219281331e-80 miRanda -0.754276684620611 4.55065794526755e-30 NA NA NA hsa-miR-28-5p LMBR1 -0.14267073663385 0.0497619246260571 0.257517541171637 0.000199666000515199 miRanda -0.108414415821819 0.00101794134974501 NA NA NA hsa-miR-107 LMOD1 0.678998026350662 2.56224148930538e-16 -2.92260102467088 6.24028357398509e-81 miRanda -0.738103862277349 4.91460629014333e-28 NA NA NA hsa-miR-324-5p LMOD1 0.211552647440779 0.139408130311654 -2.92260102467088 6.24028357398509e-81 miRanda -0.387391322511971 1.77029480514538e-22 NA NA NA hsa-miR-330-5p LMOD1 0.626063225953928 3.42215028606779e-09 -2.92260102467088 6.24028357398509e-81 miRanda -0.55160919624713 2.79608395668793e-25 NA NA NA hsa-miR-320b LPL 0.412787504747938 0.00113457276903985 -4.76546687547349 3.50748312245382e-101 miRanda -0.216402611239449 0.00166825697749889 NA NA NA hsa-miR-342-3p LPL 1.21944481975657 6.81914373001202e-19 -4.76546687547349 3.50748312245382e-101 miRanda -0.51122227596507 4.35695610941655e-17 NA NA NA hsa-miR-590-3p LPL 1.27438512890514 1.03164723481469e-23 -4.76546687547349 3.50748312245382e-101 miRanda -0.500914890750911 3.27314686967974e-13 NA NA NA hsa-miR-28-5p LRBA -0.14267073663385 0.0497619246260571 0.322142018050458 0.00274814169043239 miRanda -0.389047436907926 1.37870639587549e-14 NA NA NA hsa-miR-28-5p LRP10 -0.14267073663385 0.0497619246260571 -0.0382360620439677 0.56834890677188 miRanda -0.232358089130676 1.36883684380908e-13 NA NA NA hsa-miR-28-5p LRP2 -0.14267073663385 0.0497619246260571 -0.807564034442771 0.0466284114536984 miRanda -0.905474552810496 2.5991405316078e-06 NA NA NA hsa-miR-28-5p LRRC23 -0.14267073663385 0.0497619246260571 0.541913603183654 5.14487768181524e-09 miRanda -0.226789849549492 3.09023884401323e-07 NA NA NA hsa-miR-28-5p LRRC27 -0.14267073663385 0.0497619246260571 0.371914716525773 3.80448230629096e-06 miRanda -0.19704546268143 2.64263982844557e-07 NA NA NA hsa-miR-28-5p LRRC36 -0.14267073663385 0.0497619246260571 0.665572655767599 8.70102599652953e-05 miRanda -0.198204775980699 0.0145691548364303 NA NA NA hsa-miR-28-5p LRRC37A2 -0.14267073663385 0.0497619246260571 -0.416297658622351 0.00031793945065914 miRanda -0.124952509526358 0.0237623784992372 NA NA NA hsa-miR-375 LRRN4 2.09893673049766 1.68351780396203e-16 -0.503728500666719 0.0217590514644291 miRanda -0.126541134438762 1.18033235605568e-05 NA NA NA hsa-miR-142-3p LTBP4 1.53951237846104 2.06769936282034e-17 -1.83560605523095 5.70400897941708e-52 miRanda -0.266824065963458 5.6552606486877e-31 NA NA NA hsa-miR-590-3p LTBP4 1.27438512890514 1.03164723481469e-23 -1.83560605523095 5.70400897941708e-52 miRanda -0.433064009764942 2.70123652189e-37 NA NA NA hsa-miR-28-5p LY6G6C -0.14267073663385 0.0497619246260571 -0.0705387494557708 0.809641114829419 miRanda -0.561824988628232 5.33804138289076e-05 NA NA NA hsa-miR-28-5p LYPD3 -0.14267073663385 0.0497619246260571 1.45248580283244 1.87328918691671e-19 miRanda -0.424567607281884 5.19217038033921e-08 NA NA NA hsa-miR-590-3p LYVE1 1.27438512890514 1.03164723481469e-23 -5.04657514150624 3.33646442485093e-119 miRanda -0.57219661899711 4.63560103207724e-17 NA NA NA hsa-miR-320b MAB21L1 0.412787504747938 0.00113457276903985 -3.1633215206801 6.46152245073731e-60 miRanda -0.391275316598892 3.05189740883904e-12 NA NA NA hsa-miR-338-3p MAB21L1 0.0799903526884966 0.575137668326679 -3.1633215206801 6.46152245073731e-60 miRanda -0.128067563623343 0.0109148434759112 NA NA NA hsa-miR-590-3p MAB21L1 1.27438512890514 1.03164723481469e-23 -3.1633215206801 6.46152245073731e-60 miRanda -0.757710862738266 4.81284596482959e-44 NA NA NA hsa-miR-590-5p MAB21L1 0.746515607868274 8.51300479640125e-09 -3.1633215206801 6.46152245073731e-60 miRanda -0.671613720026351 1.61638643928567e-37 NA NA NA hsa-miR-28-5p MAGI1 -0.14267073663385 0.0497619246260571 -1.26305301454899 4.04392522280675e-34 miRanda -0.116369081008409 0.0239851302853459 NA NA NA hsa-miR-28-5p MANEAL -0.14267073663385 0.0497619246260571 1.38973021457614 4.18422007286845e-24 miRanda -0.206194475853567 0.00217111584739488 NA NA NA hsa-miR-125a-3p MAOA -0.176412960953959 0.10108079286419 -3.84771913109408 4.0234860274841e-58 miRanda -0.181291021905962 0.0282455014497468 NA NA NA hsa-miR-146b-5p MAOA 0.631041661167954 6.20366593452965e-08 -3.84771913109408 4.0234860274841e-58 miRanda -0.490716515901674 4.76687342953389e-11 NA NA NA hsa-miR-590-3p MAOA 1.27438512890514 1.03164723481469e-23 -3.84771913109408 4.0234860274841e-58 miRanda -0.65902619309321 1.51637952156816e-21 NA NA NA hsa-miR-590-5p MAOA 0.746515607868274 8.51300479640125e-09 -3.84771913109408 4.0234860274841e-58 miRanda -0.604924080984852 6.37544083906996e-20 NA NA NA hsa-miR-320b MAOB 0.412787504747938 0.00113457276903985 -2.21746394805708 9.66658929756361e-17 miRanda -0.208386349320173 0.0048132548963962 NA NA NA hsa-miR-590-3p MAOB 1.27438512890514 1.03164723481469e-23 -2.21746394805708 9.66658929756361e-17 miRanda -0.39679551869028 9.44898326424979e-08 NA NA NA hsa-miR-28-5p MAP1A -0.14267073663385 0.0497619246260571 -0.89250845462883 6.21955962799672e-15 miRanda -0.149629797196379 0.00694585072219689 NA NA NA hsa-miR-28-5p MARCH9 -0.14267073663385 0.0497619246260571 0.898335673282321 1.98480673766822e-29 miRanda -0.209424733313088 8.51235136745986e-08 NA NA NA hsa-miR-28-5p MARVELD2 -0.14267073663385 0.0497619246260571 1.12359621955454 1.74234529410055e-20 miRanda -0.411412447084188 1.81375532045569e-12 NA NA NA hsa-miR-28-5p MAT2A -0.14267073663385 0.0497619246260571 0.106201174005506 0.0211943042401361 miRanda -0.117893335118824 5.76635278592976e-08 NA NA NA hsa-miR-375 MATN2 2.09893673049766 1.68351780396203e-16 -3.29740104225744 3.25541820206151e-67 miRanda -0.227583597666673 2.21902441570678e-17 NA NA NA hsa-miR-590-3p MATN2 1.27438512890514 1.03164723481469e-23 -3.29740104225744 3.25541820206151e-67 miRanda -0.467319394997235 6.66736612020705e-17 NA NA NA hsa-miR-590-5p MATN2 0.746515607868274 8.51300479640125e-09 -3.29740104225744 3.25541820206151e-67 miRanda -0.373584253002543 3.82565531696959e-12 NA NA NA hsa-miR-28-5p MAX -0.14267073663385 0.0497619246260571 0.189520873245771 3.41527676404311e-05 miRanda -0.126434947821145 4.87379608519139e-09 NA NA NA hsa-miR-28-5p MAZ -0.14267073663385 0.0497619246260571 1.53688020659836 2.44860030148443e-84 miRanda -0.16614489256984 6.82417495538852e-05 NA NA NA hsa-miR-375 MDGA2 2.09893673049766 1.68351780396203e-16 -0.343323084924894 0.199326841381384 miRanda -0.210140933488348 1.8917655333525e-09 NA NA NA hsa-miR-155-5p MECP2 1.09766314984151 4.55650930885814e-15 -0.461019995437165 5.63618149586866e-20 miRTarBase -0.102731348764786 2.80643834434928e-17 NA NA NA hsa-miR-28-5p MED24 -0.14267073663385 0.0497619246260571 0.522193665864754 1.4256037186934e-07 miRanda -0.136336954991214 0.00416518893178145 NA NA NA hsa-miR-28-5p MED29 -0.14267073663385 0.0497619246260571 0.407823011340064 6.51199119798712e-14 miRanda -0.166233170354608 1.57916262167401e-10 NA NA NA hsa-miR-21-5p MEF2C 2.32007501846389 3.08394781855554e-137 -1.3628193091141 3.63471865869307e-46 miRTarBase -0.349922334680877 1.22856305351208e-30 NA NA NA hsa-miR-28-5p MEGF9 -0.14267073663385 0.0497619246260571 -0.296058092250146 0.0106105936693003 miRanda -0.275598713069223 5.27830665815295e-07 NA NA NA hsa-miR-28-5p MESDC1 -0.14267073663385 0.0497619246260571 0.579182445134239 2.26276233786632e-17 miRanda -0.100322410657288 0.00245928979734788 NA NA NA hsa-miR-590-3p MFAP4 1.27438512890514 1.03164723481469e-23 -2.84875423830742 1.42983321042193e-39 miRanda -0.710552520831879 3.32559451875046e-32 NA NA NA hsa-miR-320b MFAP5 0.412787504747938 0.00113457276903985 -1.7372996699481 1.15820603382006e-18 miRanda -0.153737987084261 0.00494116044855495 NA NA NA hsa-miR-361-5p MFAP5 -0.0996867547900457 0.095428250126326 -1.7372996699481 1.15820603382006e-18 miRanda -0.472200194963825 5.5911691834756e-05 NA NA NA hsa-miR-429 MFAP5 2.84108892259147 3.88520896426515e-64 -1.7372996699481 1.15820603382006e-18 miRanda -0.362088653325579 2.10248513316363e-22 NA NA NA hsa-miR-590-3p MFAP5 1.27438512890514 1.03164723481469e-23 -1.7372996699481 1.15820603382006e-18 miRanda -0.286800933293875 1.8764047768299e-07 NA NA NA hsa-miR-375 MICAL3 2.09893673049766 1.68351780396203e-16 -0.95590506366019 6.06115901437355e-27 miRanda -0.118006907235479 1.37244335048099e-23 NA NA NA hsa-miR-28-5p MID2 -0.14267073663385 0.0497619246260571 -0.799925928617615 7.05192180338706e-20 miRanda -0.132368175980547 0.00192648108990026 NA NA NA hsa-miR-375 MMD 2.09893673049766 1.68351780396203e-16 -2.29894276851442 1.03228947173554e-69 miRanda -0.158611813569505 6.69752073427209e-18 NA NA NA hsa-miR-429 MME 2.84108892259147 3.88520896426515e-64 -4.18607277920172 1.04864183760856e-76 miRanda -0.616588808767003 3.03295491941195e-43 NA NA NA hsa-miR-590-3p MME 1.27438512890514 1.03164723481469e-23 -4.18607277920172 1.04864183760856e-76 miRanda -0.577777587307535 7.20631727015262e-18 NA NA NA hsa-miR-28-5p MMP11 -0.14267073663385 0.0497619246260571 6.04945497433362 1.03023931867355e-137 miRanda -0.429299903434847 0.00172361360383875 NA NA NA hsa-miR-193a-3p MMRN1 0.310617999804917 0.00477640270974957 -4.02160527181333 2.62445526488168e-53 miRanda -0.579369064144891 1.97276549575571e-11 NA NA NA hsa-miR-324-5p MMRN1 0.211552647440779 0.139408130311654 -4.02160527181333 2.62445526488168e-53 miRanda -0.683852779093212 8.669224160049e-26 NA NA NA hsa-miR-330-5p MMRN1 0.626063225953928 3.42215028606779e-09 -4.02160527181333 2.62445526488168e-53 miRanda -0.659111463986946 1.16192205056813e-13 NA NA NA hsa-miR-590-3p MMRN1 1.27438512890514 1.03164723481469e-23 -4.02160527181333 2.62445526488168e-53 miRanda -0.762019260418269 2.27347275376265e-24 NA NA NA hsa-miR-15a-5p MN1 0.812445324157528 4.50263417099822e-20 -0.459509646859896 0.00118312104981719 miRTarBase -0.361033926863642 1.38087332538e-11 NA NA NA hsa-miR-28-5p MORF4L2 -0.14267073663385 0.0497619246260571 0.754044361942787 2.09810836739711e-29 miRanda -0.148347261398627 6.48658571412929e-06 NA NA NA hsa-miR-28-5p MOV10L1 -0.14267073663385 0.0497619246260571 -0.297466473208126 0.0920646073093874 miRanda -0.200559727756046 0.017178490274872 NA NA NA hsa-miR-28-5p MPI -0.14267073663385 0.0497619246260571 0.028970874839473 0.6353259007928 miRanda -0.168930693478824 4.35470728606857e-09 NA NA NA hsa-miR-28-5p MR1 -0.14267073663385 0.0497619246260571 0.327436070496887 0.000151124551464722 miRanda -0.11465704514548 0.00545481477812533 NA NA NA hsa-miR-28-5p MRPL17 -0.14267073663385 0.0497619246260571 1.00679596033877 1.95241823571098e-45 miRanda -0.107583871355843 0.00267303465044058 NA NA NA hsa-miR-28-5p MRPS35 -0.14267073663385 0.0497619246260571 0.546529477360202 2.2953747137935e-18 miRanda -0.11368310884075 0.000176002275848875 NA NA NA hsa-miR-28-5p MS4A2 -0.14267073663385 0.0497619246260571 -0.791944427086409 0.00109280176197654 miRanda -1.00321375313711 9.28749255223754e-19 NA NA NA hsa-miR-107 MT1M 0.678998026350662 2.56224148930538e-16 -2.62480659969882 3.21684237424355e-37 miRanda -0.285157313121187 0.00121374952177233 NA NA NA hsa-miR-342-3p MT1M 1.21944481975657 6.81914373001202e-19 -2.62480659969882 3.21684237424355e-37 miRanda -0.442093852201011 1.23222770623315e-17 NA NA NA hsa-miR-330-5p MT1X 0.626063225953928 3.42215028606779e-09 -1.97085666919662 4.42505314982976e-34 miRanda -0.231583263147819 1.91407683724882e-05 NA NA NA hsa-miR-21-5p MTAP 2.32007501846389 3.08394781855554e-137 -0.205567553133638 0.017351504048108 miRTarBase -0.111192139316398 3.46052582192821e-05 NA NA NA hsa-miR-375 MUC15 2.09893673049766 1.68351780396203e-16 -3.21987405974139 1.03371381531784e-15 miRanda -0.334495109211679 3.80448822962048e-10 NA NA NA hsa-miR-28-5p MUC2 -0.14267073663385 0.0497619246260571 2.26355229838227 1.52647808582801e-07 miRanda -1.17344429096599 1.12063804571833e-08 NA NA NA hsa-miR-28-5p MUM1 -0.14267073663385 0.0497619246260571 -0.126556156553718 0.0782751092469258 miRanda -0.129631276755681 0.000144830852269932 NA NA NA hsa-miR-28-5p MUM1L1 -0.14267073663385 0.0497619246260571 -0.158739344936463 0.536343388622944 miRanda -0.704525822706198 6.29784602575918e-09 NA NA NA hsa-miR-155-5p MYB 1.09766314984151 4.55650930885814e-15 1.3385004671291 4.8746375657764e-10 miRTarBase -0.302949826442919 5.53369049741093e-09 NA NA NA hsa-miR-15a-5p MYB 0.812445324157528 4.50263417099822e-20 1.3385004671291 4.8746375657764e-10 miRTarBase -0.295988774508509 0.000337113835483446 NA NA NA hsa-miR-28-5p MYB -0.14267073663385 0.0497619246260571 1.3385004671291 4.8746375657764e-10 miRanda -0.793948725008808 6.86876365185527e-15 NA NA NA hsa-miR-590-3p MYBPC1 1.27438512890514 1.03164723481469e-23 -3.87680425164615 5.00636259933228e-16 miRanda -0.53333436776677 6.49088837321352e-05 NA NA NA hsa-miR-28-5p MYCBPAP -0.14267073663385 0.0497619246260571 0.270395883018356 0.168169145671457 miRanda -0.521583955632841 1.89815971070376e-08 NA NA NA hsa-miR-28-5p MYEF2 -0.14267073663385 0.0497619246260571 0.553427331133231 2.34778821065553e-05 miRanda -0.154420149585165 0.0136797924479402 NA NA NA hsa-miR-107 MYH11 0.678998026350662 2.56224148930538e-16 -4.00418731194589 4.62113517064913e-66 miRanda -1.04562216824545 3.003561978703e-25 NA NA NA hsa-miR-146b-5p MYH11 0.631041661167954 6.20366593452965e-08 -4.00418731194589 4.62113517064913e-66 miRanda -0.200578391279767 0.00686791528409065 NA NA NA hsa-miR-193a-3p MYH11 0.310617999804917 0.00477640270974957 -4.00418731194589 4.62113517064913e-66 miRanda -0.511842754833486 6.30628829322658e-11 NA NA NA hsa-miR-338-3p MYH11 0.0799903526884966 0.575137668326679 -4.00418731194589 4.62113517064913e-66 miRanda -0.174955191735712 0.0041385364178511 NA NA NA hsa-miR-590-5p MYH11 0.746515607868274 8.51300479640125e-09 -4.00418731194589 4.62113517064913e-66 miRanda -0.75448806915142 5.84623730261276e-32 NA NA NA hsa-miR-28-5p MYLIP -0.14267073663385 0.0497619246260571 -0.57505884257391 2.93951647319766e-11 miRanda -0.271745980842622 4.32764111087329e-11 NA NA NA hsa-miR-107 MYLK 0.678998026350662 2.56224148930538e-16 -2.468210552686 9.30073457733719e-63 miRanda -0.727441031317099 7.55254848021747e-31 NA NA NA hsa-miR-142-3p MYLK 1.53951237846104 2.06769936282034e-17 -2.468210552686 9.30073457733719e-63 miRanda -0.109303156504941 0.000215677439149484 NA NA NA hsa-miR-193a-3p MYLK 0.310617999804917 0.00477640270974957 -2.468210552686 9.30073457733719e-63 miRanda -0.183797302313369 0.000221311854270132 NA NA NA hsa-miR-320b MYLK 0.412787504747938 0.00113457276903985 -2.468210552686 9.30073457733719e-63 miRanda -0.146562676450802 0.000723733397528372 NA NA NA hsa-miR-429 MYLK 2.84108892259147 3.88520896426515e-64 -2.468210552686 9.30073457733719e-63 miRanda -0.336023519715106 1.14874203218121e-30 NA NA NA hsa-miR-590-3p MYLK 1.27438512890514 1.03164723481469e-23 -2.468210552686 9.30073457733719e-63 miRanda -0.319629509007646 1.61044526555788e-13 NA NA NA hsa-miR-590-5p MYLK 0.746515607868274 8.51300479640125e-09 -2.468210552686 9.30073457733719e-63 miRanda -0.207142520900471 7.06320969717734e-07 NA NA NA hsa-miR-375 MYO16 2.09893673049766 1.68351780396203e-16 -2.34133577954585 2.69114939800743e-28 miRanda -0.149229357803358 2.24861624890983e-07 NA NA NA hsa-miR-28-5p MYO5C -0.14267073663385 0.0497619246260571 -0.148719986034905 0.196143460079208 miRanda -0.387154085850764 8.02386753686477e-13 NA NA NA hsa-miR-324-5p MYOC 0.211552647440779 0.139408130311654 -7.10013341821606 5.26897036785651e-115 miRanda -0.375777634663432 1.25824393272113e-05 NA NA NA hsa-miR-590-3p MYOC 1.27438512890514 1.03164723481469e-23 -7.10013341821606 5.26897036785651e-115 miRanda -0.963316110956421 1.52459626267796e-23 NA NA NA hsa-miR-28-5p MYOZ3 -0.14267073663385 0.0497619246260571 -0.711322284940144 0.000149018891882461 miRanda -0.341141244970893 0.000137356928333869 NA NA NA hsa-miR-28-5p MYT1 -0.14267073663385 0.0497619246260571 3.12383178963035 2.84482084584268e-20 miRanda -0.858419706373622 1.75550265549345e-07 NA NA NA hsa-miR-28-5p NAGPA -0.14267073663385 0.0497619246260571 0.476491606622916 3.65876806231442e-10 miRanda -0.100081318214584 0.00618236613995102 NA NA NA hsa-miR-28-5p NAV1 -0.14267073663385 0.0497619246260571 -0.159057359476455 0.12674105203339 miRanda -0.148433487492913 0.00274439035375534 NA NA NA hsa-miR-125a-3p NAV3 -0.176412960953959 0.10108079286419 -1.78347027501907 7.45924181306669e-19 miRanda -0.2456998617264 0.000186941760941319 NA NA NA hsa-miR-142-3p NAV3 1.53951237846104 2.06769936282034e-17 -1.78347027501907 7.45924181306669e-19 miRanda -0.269413581093503 7.74088587739465e-13 NA NA NA hsa-miR-193a-3p NAV3 0.310617999804917 0.00477640270974957 -1.78347027501907 7.45924181306669e-19 miRanda -0.269725420265586 2.47578691339638e-05 NA NA NA hsa-miR-330-5p NAV3 0.626063225953928 3.42215028606779e-09 -1.78347027501907 7.45924181306669e-19 miRanda -0.49970393962902 1.76436709793844e-14 NA NA NA hsa-miR-339-5p NAV3 -0.211548290465418 0.0685885445822389 -1.78347027501907 7.45924181306669e-19 miRanda -0.151009771976208 0.013104192581369 NA NA NA hsa-miR-429 NAV3 2.84108892259147 3.88520896426515e-64 -1.78347027501907 7.45924181306669e-19 miRanda -0.358345681713078 4.52010231538842e-21 NA NA NA hsa-miR-590-3p NAV3 1.27438512890514 1.03164723481469e-23 -1.78347027501907 7.45924181306669e-19 miRanda -0.521711682286339 3.27057958465505e-21 NA NA NA hsa-miR-375 NCAM1 2.09893673049766 1.68351780396203e-16 -2.68069543446954 3.3168998510845e-39 miRanda -0.198115775974143 1.485607378779e-12 NA NA NA hsa-miR-375 NCK2 2.09893673049766 1.68351780396203e-16 -0.17107267799518 0.0284008553186183 miRanda -0.121755499845819 5.16363636354373e-35 NA NA NA hsa-miR-28-5p NDE1 -0.14267073663385 0.0497619246260571 0.875339226885404 7.92857237232874e-36 miRanda -0.103552782556862 0.00294271629492361 NA NA NA hsa-miR-330-5p NDRG2 0.626063225953928 3.42215028606779e-09 -2.5572531779346 1.44945093855248e-67 miRanda -0.30447596751734 2.69942100196556e-09 NA NA NA hsa-miR-28-5p NDUFS4 -0.14267073663385 0.0497619246260571 -0.301526713163377 1.63649105931826e-06 miRanda -0.15098636267489 4.48455928241219e-07 NA NA NA hsa-miR-28-5p NECAP1 -0.14267073663385 0.0497619246260571 0.194681737356563 0.00227095720937965 miRanda -0.157152843023967 1.95426624970528e-07 NA NA NA hsa-miR-28-5p NEIL2 -0.14267073663385 0.0497619246260571 -0.0448079050208445 0.544773057514391 miRanda -0.119176975433056 0.000691336086998745 NA NA NA hsa-miR-28-5p NEK11 -0.14267073663385 0.0497619246260571 0.128069407523834 0.188727293195575 miRanda -0.207811713330311 6.84039361090454e-06 NA NA NA hsa-miR-28-5p NEK9 -0.14267073663385 0.0497619246260571 -0.60343465464345 2.91093269226533e-23 miRanda -0.211923929411196 4.69742347617414e-13 NA NA NA hsa-miR-28-5p NELL1 -0.14267073663385 0.0497619246260571 0.559671843191762 0.100112035151243 miRanda -0.443668109807395 0.00622745471416146 NA NA NA hsa-miR-375 NEUROG2 2.09893673049766 1.68351780396203e-16 -3.49220493818278 4.92374916601517e-33 miRanda -0.10200350297199 0.0109705473649656 NA NA NA hsa-miR-28-5p NF1 -0.14267073663385 0.0497619246260571 -0.394546709839459 1.88157518863882e-05 miRanda -0.10961770733041 0.0129522477508265 NA NA NA hsa-miR-21-5p NFIB 2.32007501846389 3.08394781855554e-137 -2.2930778520164 2.43578303149819e-46 miRTarBase -0.565176447004213 2.99659929184389e-28 NA NA NA hsa-miR-429 NFIB 2.84108892259147 3.88520896426515e-64 -2.2930778520164 2.43578303149819e-46 miRanda -0.2170227713871 9.48620584277076e-12 NA NA NA hsa-miR-28-5p NKAIN1 -0.14267073663385 0.0497619246260571 3.58782119473036 3.15479732457313e-27 miRanda -1.02962002614055 2.05084781347217e-10 NA NA NA hsa-miR-429 NLGN4X 2.84108892259147 3.88520896426515e-64 -2.18618561323443 1.18944185794112e-21 miRanda -0.350288596551171 1.15376606436417e-15 NA NA NA hsa-miR-590-3p NLGN4X 1.27438512890514 1.03164723481469e-23 -2.18618561323443 1.18944185794112e-21 miRanda -0.349814090308158 4.83392996475991e-08 NA NA NA hsa-miR-28-5p NLK -0.14267073663385 0.0497619246260571 0.568183653225175 4.68554951142873e-14 miRanda -0.182841180159811 4.4803820168759e-07 NA NA NA hsa-miR-28-5p NPNT -0.14267073663385 0.0497619246260571 1.30537723017584 8.93205976672538e-11 miRanda -0.721622294532342 4.48461531437353e-14 NA NA NA hsa-miR-590-3p NPR1 1.27438512890514 1.03164723481469e-23 -3.47200023786899 1.81960056893608e-101 miRanda -0.513731000776169 1.76580204065344e-25 NA NA NA hsa-miR-375 NPY2R 2.09893673049766 1.68351780396203e-16 -6.45797875341372 3.62051092663934e-66 miRanda -0.24132197662179 7.06363645304762e-06 NA NA NA hsa-miR-107 NR4A2 0.678998026350662 2.56224148930538e-16 -1.00418520415067 2.70589249007797e-09 miRanda -0.350764202922249 4.19729960713514e-07 NA NA NA hsa-miR-142-3p NR4A2 1.53951237846104 2.06769936282034e-17 -1.00418520415067 2.70589249007797e-09 miRanda -0.144785633524181 4.11163246252253e-06 NA NA NA hsa-miR-19a-3p NR4A2 0.817507952171848 3.76285090469625e-08 -1.00418520415067 2.70589249007797e-09 miRTarBase -0.267744962162051 3.84874721123264e-12 NA NA NA hsa-miR-320b NR4A2 0.412787504747938 0.00113457276903985 -1.00418520415067 2.70589249007797e-09 miRanda -0.154385970118871 0.000842026649657728 NA NA NA hsa-miR-361-5p NR4A2 -0.0996867547900457 0.095428250126326 -1.00418520415067 2.70589249007797e-09 miRanda -0.302985501346328 0.00229733865083645 NA NA NA hsa-miR-429 NR4A2 2.84108892259147 3.88520896426515e-64 -1.00418520415067 2.70589249007797e-09 miRanda -0.149995583574573 3.08213760299521e-06 NA NA NA hsa-miR-455-5p NR4A2 0.284641224662773 0.0357572339594277 -1.00418520415067 2.70589249007797e-09 miRanda -0.287799731469565 1.55565542042367e-11 NA NA NA hsa-miR-590-3p NR4A2 1.27438512890514 1.03164723481469e-23 -1.00418520415067 2.70589249007797e-09 miRanda -0.272255515924961 4.69172835585602e-09 NA NA NA hsa-miR-28-5p NRSN2 -0.14267073663385 0.0497619246260571 1.0077861189057 1.12746017285371e-32 miRanda -0.248146104353577 2.4591706014397e-09 NA NA NA hsa-miR-21-5p NTF3 2.32007501846389 3.08394781855554e-137 -2.35193065681614 1.75397805257351e-24 miRTarBase -0.481266108265449 4.86045305948914e-11 NA NA NA hsa-miR-28-5p NTM -0.14267073663385 0.0497619246260571 0.221487289190883 0.123560204043128 miRanda -0.157071376888052 0.0219271809832237 NA NA NA hsa-miR-107 NTRK2 0.678998026350662 2.56224148930538e-16 -4.03565225718056 9.2986992242195e-64 miRanda -0.836390405916991 1.12926053720617e-15 NA NA NA hsa-miR-142-3p NTRK2 1.53951237846104 2.06769936282034e-17 -4.03565225718056 9.2986992242195e-64 miRanda -0.311735989864694 5.64944316358857e-11 NA NA NA hsa-miR-146b-5p NTRK2 0.631041661167954 6.20366593452965e-08 -4.03565225718056 9.2986992242195e-64 miRanda -0.314474616023657 3.27685992622639e-05 NA NA NA hsa-miR-200c-3p NTRK2 2.07038651806183 6.84613386286599e-51 -4.03565225718056 9.2986992242195e-64 miRTarBase -0.540459062838814 7.12630091174492e-20 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-330-5p NTRK2 0.626063225953928 3.42215028606779e-09 -4.03565225718056 9.2986992242195e-64 miRanda -0.478715290991117 7.66297627939398e-09 NA NA NA hsa-miR-342-3p NTRK2 1.21944481975657 6.81914373001202e-19 -4.03565225718056 9.2986992242195e-64 miRanda -0.259575565229622 4.07249780461087e-05 NA NA NA hsa-miR-429 NTRK2 2.84108892259147 3.88520896426515e-64 -4.03565225718056 9.2986992242195e-64 miRanda -0.51698534306774 1.82175500468262e-27 NA NA NA hsa-miR-590-3p NTRK2 1.27438512890514 1.03164723481469e-23 -4.03565225718056 9.2986992242195e-64 miRanda -0.630708695964853 1.65227664250245e-19 NA NA NA hsa-miR-590-5p NTRK2 0.746515607868274 8.51300479640125e-09 -4.03565225718056 9.2986992242195e-64 miRanda -0.533409974311982 1.82799161345103e-15 NA NA NA hsa-miR-28-5p NUAK1 -0.14267073663385 0.0497619246260571 -0.914610809156931 1.8807905701441e-17 miRanda -0.131373331691557 0.0120066009154216 NA NA NA hsa-miR-28-5p NUAK2 -0.14267073663385 0.0497619246260571 2.20281585866602 3.89561828942553e-79 miRanda -0.37596435617299 7.22431489231184e-10 NA NA NA hsa-miR-28-5p NUCB2 -0.14267073663385 0.0497619246260571 0.670385380475985 8.68806334102954e-09 miRanda -0.280586626471 4.66620702358173e-07 NA NA NA hsa-miR-28-5p NUDT13 -0.14267073663385 0.0497619246260571 -0.458684101138813 1.49139282091863e-06 miRanda -0.124661710754265 0.00631011761644721 NA NA NA hsa-miR-142-3p OGN 1.53951237846104 2.06769936282034e-17 -3.74251776056207 6.49487466193206e-39 miRanda -0.491836239820298 2.04320356847779e-19 NA NA NA hsa-miR-146b-5p OGN 0.631041661167954 6.20366593452965e-08 -3.74251776056207 6.49487466193206e-39 miRanda -0.359979696957095 4.18246434240121e-05 NA NA NA hsa-miR-193a-3p OGN 0.310617999804917 0.00477640270974957 -3.74251776056207 6.49487466193206e-39 miRanda -0.598380145996354 1.25288559958333e-10 NA NA NA hsa-miR-320b OGN 0.412787504747938 0.00113457276903985 -3.74251776056207 6.49487466193206e-39 miRanda -0.56516006676233 2.67867173756375e-12 NA NA NA hsa-miR-429 OGN 2.84108892259147 3.88520896426515e-64 -3.74251776056207 6.49487466193206e-39 miRanda -0.719884071151354 4.5471663387038e-40 NA NA NA hsa-miR-590-3p OGN 1.27438512890514 1.03164723481469e-23 -3.74251776056207 6.49487466193206e-39 miRanda -1.1172886576495 2.57291289889746e-46 NA NA NA hsa-miR-28-5p OLFM1 -0.14267073663385 0.0497619246260571 -0.806833993567473 2.33080631095537e-05 miRanda -0.434330191870437 1.74743829260296e-06 NA NA NA hsa-miR-107 OLFM4 0.678998026350662 2.56224148930538e-16 -3.95165117472039 3.48126882343483e-21 miRanda -0.960643870038514 3.55921717799736e-08 NA NA NA hsa-miR-338-3p OLFM4 0.0799903526884966 0.575137668326679 -3.95165117472039 3.48126882343483e-21 miRanda -0.30527640981046 0.00309986788786775 NA NA NA hsa-miR-339-5p OLFM4 -0.211548290465418 0.0685885445822389 -3.95165117472039 3.48126882343483e-21 miRanda -0.353246537928903 0.0053935350148804 NA NA NA hsa-miR-590-3p OLFM4 1.27438512890514 1.03164723481469e-23 -3.95165117472039 3.48126882343483e-21 miRanda -0.319979386743044 0.00667400376656005 NA NA NA hsa-miR-28-5p OLFML3 -0.14267073663385 0.0497619246260571 -0.484779181334281 4.26190141017196e-05 miRanda -0.146634750872719 0.00964142489546047 NA NA NA hsa-miR-28-5p OSBPL10 -0.14267073663385 0.0497619246260571 -0.0654040479624038 0.460318540732145 miRanda -0.114725848755068 0.00646868684724235 NA NA NA hsa-miR-28-5p OSBPL7 -0.14267073663385 0.0497619246260571 0.0588084177089319 0.550542377722673 miRanda -0.160386070710978 0.000610888019257143 NA NA NA hsa-miR-28-5p OTUB1 -0.14267073663385 0.0497619246260571 0.743708114973462 2.76727756237135e-34 miRTarBase -0.114501198557697 0.000145943210829922 NA NA NA hsa-miR-28-5p OTUB2 -0.14267073663385 0.0497619246260571 1.04819143562664 1.51953841962343e-30 miRanda -0.149357921381267 0.000915308983616309 NA NA NA hsa-miR-590-5p OXTR 0.746515607868274 8.51300479640125e-09 -4.04712904491628 1.48672631195987e-66 miRanda -0.399071341493331 2.02844254873861e-09 NA NA NA hsa-miR-28-5p PAFAH2 -0.14267073663385 0.0497619246260571 0.274540087069485 2.25730801999012e-05 miRanda -0.181474588639603 3.33470892114403e-09 NA NA NA hsa-miR-28-5p PAN2 -0.14267073663385 0.0497619246260571 -0.417044459562392 2.76743472392804e-09 miRanda -0.17925739666463 8.53714401819021e-08 NA NA NA hsa-miR-375 PAPSS2 2.09893673049766 1.68351780396203e-16 -0.461710787649865 0.00692436810210827 miRanda -0.129630277264201 7.27615537106171e-09 NA NA NA hsa-miR-375 PARP15 2.09893673049766 1.68351780396203e-16 -0.317557340101165 0.0912814583622492 miRanda -0.13903017285142 1.65259892712365e-08 NA NA NA hsa-miR-28-5p PCDH10 -0.14267073663385 0.0497619246260571 -0.589847783454892 0.0702331583145207 miRanda -0.538818734654809 0.000511157836185964 NA NA NA hsa-miR-375 PCDH11X 2.09893673049766 1.68351780396203e-16 -3.35877977775092 4.73102650731164e-33 miRanda -0.27506813316742 4.81205787289436e-13 NA NA NA hsa-miR-375 PCDH18 2.09893673049766 1.68351780396203e-16 -2.07605586585207 1.98892381019284e-49 miRanda -0.159161684945795 2.10540486091919e-16 NA NA NA hsa-miR-342-3p PCOLCE2 1.21944481975657 6.81914373001202e-19 -5.34447065684793 3.25334281900878e-61 miRanda -0.799629325489688 9.25043003060431e-22 NA NA NA hsa-miR-590-3p PCOLCE2 1.27438512890514 1.03164723481469e-23 -5.34447065684793 3.25334281900878e-61 miRanda -0.379554325879054 7.63269367268395e-05 NA NA NA hsa-miR-375 PCSK5 2.09893673049766 1.68351780396203e-16 -1.92996085102886 3.3455070654901e-31 miRanda -0.164728066636985 2.25219376652025e-13 NA NA NA hsa-miR-28-5p PCSK6 -0.14267073663385 0.0497619246260571 0.33169561953974 0.0771775975214687 miRanda -0.325068253320658 0.000271228066827847 NA NA NA hsa-miR-28-5p PCYOX1 -0.14267073663385 0.0497619246260571 -1.09884998986409 7.48295373511972e-39 miRanda -0.135347671586706 0.00129452200167461 NA NA NA hsa-miR-28-5p PCYOX1L -0.14267073663385 0.0497619246260571 0.554225987753898 5.61819495077454e-16 miRanda -0.190735646180457 6.71716832065865e-09 NA NA NA hsa-miR-21-5p PDCD4 2.32007501846389 3.08394781855554e-137 -0.110829364318222 0.352934989327702 miRTarBase -0.109773096535706 0.00312356894215013 17991735;19308091;26169933;22547075;22086602;26212010;23052036;19633292;25566594;25575817;25316501;22072622;22267128;22322403;19836969;22212233;23604124;25520758;19682430;23272133;25477028;26252635;25994220;25991676;22747440;23827854;23824073;24865582;24902663;24888238;24149370;20978511;22689922;27355932;24331411;20372781;23558936;23201752;20815812;17968323;25310697;21842656;23567619;20581857;23888942;23548551;19013014;21685938;26142886;24472409;25973032;26418978;24659669;25543482;25543261;23904372;27725205;23564788;25400316;26150475;21546206;19509156;27035745;22353043;21412018;19276261;21330826;26864640;22335905;21636706 Programmed cell death 4 PDCD4 is an important functional target of the microRNA miR 21 in breast cancer cells;We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion;The results indicated that the miR-21 inhibition could induce the cell cycle arrest in G1 phase upregulate the expression of Programmed Cell Death Protein 4 PDCD4 and thus active the caspase-3 apoptosis pathway;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;The effects were accompanied by up-regulation of tumor suppressor PDCD4 a known miR-21 target; as well as up-regulation of cofilin and profilin two key proteins involved in actin polymerization and cytoskeleton maintenance as a consequence of miR-182 down-regulation;Increased levels of miR-21 in turn downregulate the expression of the metastasis-suppressor protein programmed cell death 4 PDCD4 a validated miR-21 target;Fenhexamid and fludioxonil stimulated miR-21 expression in a concentration-dependent manner and reduced the expression of miR-21 target Pdcd4 protein; Antisense to miR-21 blocked the increase in Pdcd4 protein by fenhexamid and fludioxonil;This process leads to microRNA-21 miR-21 production and a tumor suppressor protein e.g PDCD4 program cell death 4 reduction; Transfection of MCF-7 cells with PKCepsilon or Nanog-specific small interfering RNAs effectively blocks HA-mediated PKCepsilon-Nanog signaling events abrogates miR-21 production and increases PDCD4 expression/eIF4A binding;Through dual-luciferase method it was verified that PDCD4 and PDCD10 were real target genes of miR-21 and miR-200c respectively;We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells;MTCs were consistently associated with miR-21 up-regulation P < .0016 and featured significant PDCD4 nuclear down-regulation; An inverse correlation emerged between miR-21 overexpression and PDCD4 down-regulation P = .0013; This study showed in MTCs that miR-21 regulates PDCD4 expression and also that the miR-21/PDCD4 pathway correlates with clinicopathological variables and prognosis;Although microRNA-21 miR-21 is emerging as an oncogene and has been shown to target several tumor suppressor genes including programmed cell death 4 PDCD4 its precise mechanism of action on cancer stem cells CSCs is unclear; Herein we report that FOLFOX-resistant HCT-116 and HT-29 cells that are enriched in CSCs show a 3- to 7-fold upregulation of pre- and mature miR-21 and downregulation of PDCD4; Likewise overexpression of miR-21 in HCT-116 cells achieved through stable transfection led to the downregulation of PDCD4 and transforming growth factor beta receptor 2 TGFβR2;Prognostic significance of PDCD4 expression and association with microRNA 21 in each Dukes' stage of colorectal cancer patients; Furthermore relationships between the PDCD4 mRNA and microRNA-21 miR-21 were evaluated; The PDCD4 mRNA was investigated by the quantitative real-time RT-PCR method and miR-21 was examined by TaqMan microRNA assays; Significant inverse correlations were demonstrated between PDCD4 and miR-21;miR 21 promotes migration and invasion by the miR 21 PDCD4 AP 1 feedback loop in human hepatocellular carcinoma; The expression level of miR-21 was inversely correlated with the protein expression level of a previously identified target gene programmed cell death 4 PDCD4;This short review will focus on our recent finding that the microRNA miR-21 posttranscriptionally regulates Pdcd4 as well as invasion intravasation and metastasis;PDCD4 expression inversely correlated with miR 21 levels in gastric cancers;HBx mediated miR 21 upregulation represses tumor suppressor function of PDCD4 in hepatocellular carcinoma; HBx downregulates PDCD4 expression at least partially through miR-21; Taken together this study reported for the first time that HBx downregulates PDCD4 and upregulates miR-21 expression; The deregulation of PDCD4 by HBx through miR-21 represents a potential novel mechanism of the downregulation of PDCD4 in HBV-related HCC and provides new insights into HCC development;MicroRNA 21 Down regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma; MicroRNA-21 miR-21 possesses the oncogenic potential to target several tumor suppressor genes including PDCD4 and regulates tumor progression and metastasis; However the mechanism of how miR-21 regulates PDCD4 is poorly understood in RB; Using the TargetScan program we identified a list of potential target genes of these miRNAs of which PDCD4 is one the targets of miR-21; In this study we focused on the regulatory mechanism of miR-21 on PDCD4 in RB; We demonstrated an inverse correlation between miR-21 and PDCD4 expression in Weri-Rb1 and Y79 cells; These data suggest that miR-21 down-regulates Rb1 by targeting PDCD4 tumor suppressor;MicroRNA 21 promotes cell proliferation and down regulates the expression of programmed cell death 4 PDCD4 in HeLa cervical carcinoma cells; In this study we found that the inhibition of miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation and up-regulated the expression of the tumor suppressor gene PDCD4;Additionally resveratrol increased the expression of tumor suppressors PDCD4 and maspin which are negatively regulated by miR-21; Short interfering si RNA against PDCD4 attenuated resveratrol's effect on prostate cancer cells and similar effects were observed following over expression of miR-21 with pre-miR-21 oligonucleotides; MiR-21 expression in these cells appeared to be dependent on Akt as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression; These tumor- and metastatic-suppressive effects of resveratrol were associated with reduced miR-21 and pAkt and elevated PDCD4 levels;The expression of miR-21 and PDCD4 mRNA in transfected cells was quantified by real-time polymerase chain reaction and the expression of PDCD4 protein by Western blot; Cell proliferation apoptosis migration and invasion assays were performed to determine the biological effects of miR-21 expression and PDCD4 inhibition; Co-transfection of miR-21-sponge with PDCD4 siRNA upregulated miR-21 expression in these cells; PDCD4 mRNA and protein levels were increased 2.14-fold and 2.16-fold respectively following inhibition of miR-21 expression; Depletion of PDCD4 by siRNA transfection reversed the reduction of cell proliferation migration and invasion induced by inhibition of miR-21 in A549 cells; It indicates that miR-21 is highly expressed in patients with NSCLC and inhibition of miR-21 expression reduces proliferation migration and invasion of A549 cells by upregulating PDCD4 expression; Modulation of miR-21 or PDCD4 expression may provide a potentially novel therapeutic approach for NSCLC;IL 6 Inhibits the Targeted Modulation of PDCD4 by miR 21 in Prostate Cancer; In this study we evaluated the role of IL-6 in PDCD4 gene expression and how the microRNA miR-21 regulates this process in prostate cancer cell lines PC-3 and LNCaP; The expression of PDCD4 was inhibited by IL-6 but this effect was weakened in cell lines with low expression of miR-21; These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6 miR-21 and PDCD4;Furthermore the absence of miR-21 increased the expression of its target gene PDCD4 and subsequently modulated nuclear factor NF-κB activation;In this study using reverse phase protein arrays RPPAs we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes by down regulating micro RNA-21 miR-21; We also show the prognostic effect of miR21 PDCD4 and MSH2 levels to patient survival across different GBM molecular subtypes;We also analyzed the immunohistochemical expression of PDCD4 an miR-21 gene target; PDCD4 expression was significantly downregulated in MTC samples consistent with miR-21 upregulation;Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA 21 mediated programmed cell death 4 PDCD4 expression; Further AR inhibition also increased PDCD4 a putative target of miR-21 in human colon cancer cells; Collectively these results indicate that AR inhibition prevents growth factor-induced colon cancer growth by down-regulating miR-21 expression and increasing PDCD4 levels through the reactive oxygen species ROS/AMPK/mTOR/AP1/4E-BP1 pathway;Berberine could inhibit miR-21 expression and function in ovarian cancer as shown by an enhancement of its target PDCD4 an important tumor suppressor in ovarian cancer;Overexpression of miR-21 in cisplatin sensitive cells decreased PDCD4 levels and increased cell proliferation;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation proliferation and metastasis in renal cell carcinoma; MiR-21 induces neoplastic transformation cell proliferation and metastasis and downregulates programmed cell death4 PDCD4 in some cancers; The aim of this study was to investigate the roles and interactions of PDCD4 and miR-21 in human renal cell carcinoma RCC; The expression levels of PDCD4 protein and mRNA and miR-21 were examined by Western blot analysis and by qRT-PCR and luciferase reporter assays; MiR-21 not only promoted cancer cell hyperplasia and contributed to tumor cell transformation and metastasis but also post-transcriptionally downregulated PDCD4 protein expression; PDCD4 and miR-21 expression levels potentially play an important role in renal cell cancer;Programmed cell death 4 PDCD4 is a tumor suppressor gene whose expression is directly controlled by microRNA-21 miR-21; This PDCD4 and miR-21 inverse expression was also noted in cells and exosomes from OSC peritoneal effusions compared with nonneoplastic effusions; PDCD4 and miR-21 are involved in OSC oncogenesis;Finally in a subgroup of tumor specimens ROC curve analysis performed on quantitative PCR data sets for miR-21 ITGβ4 and PDCD4 shows that the combination of high miR-21 with low ITGβ4 and PDCD4 expression is able to predict presence of metastasis; In conclusion miR-21 is a key player in oncogenic EMT its overexpression is controlled by the cooperation of genetic and epigenetic alterations and its levels along with ITGβ4 and PDCD4 expression could be exploited as a prognostic tool for CRC metastasis;Transfection of anti-miR-21 rendered HCC cells sensitive to IFN-α/5-FU and such sensitivity was weakened by transfection of siRNAs of target molecules PETN and PDCD4 miR-21 expression in clinical HCC specimens was significantly associated with the clinical response to the IFN-α/5-FU combination therapy and survival rate;In ZD esophagus and tongue oncogenic miR-31 and miR-21 overexpression was accompanied by down-regulation of their respective tumor-suppressor targets PPP2R2A and PDCD4;Due to inhibition of miR-21 expression of the programed cell death 4 PDCD4 gene was promoted in tumors resulting in the induction of apoptosis of tumor cells;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;Clinicopathological and prognostic significance of PDCD4 and microRNA 21 in human gastric cancer; Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 PDCD4 is downregulated in several human solid cancer types and is suppressed by microRNA-21 miR-21; The objectives of this study were: i to establish the clinicopathological and prognostic significance of PDCD4 mRNA and ii to elucidate any correlation between PDCD4 mRNA and miR-21 in gastric cancer; We also performed an association study comparing PDCD4 mRNA and miR-21 in eight cell lines and 49 gastric cancers; An inverse correlation between PDCD4 mRNA and miR-21 was found in gastric cancer; Furthermore our findings suggest that PDCD4 mRNA is negatively regulated by miR-21 in gastric cancer and may serve as a target for effective therapies;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter and induced the expression of the tumour suppressor Pdcd4 programmed cell death protein 4 which is a target of miR-21; Taken together this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1 suppresses cell proliferation tumour growth invasion and in vivo metastasis and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion intravasation and metastasis in colorectal cancer; This is the first study to show that Pdcd4 is negatively regulated by miR-21;Inflammation and MiR 21 pathways functionally interact to downregulate PDCD4 in colorectal cancer; These findings indicate that miR-21 is a component of the COX-2 inflammation pathway and that this pathway promotes worsening of disease stage in colorectal cancer by inducing accumulation of PGE2 and increasing expression of miR-21 with consequent downregulation of the tumour suppressor gene PDCD4;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Interestingly NVP-LDE-225 induced PDCD4 and apoptosis and inhibited cell viability by suppressing miR-21;PDCD4 a direct target gene of miR-21 could mediate chemoresistance to docetaxel in PC3 cells;Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR 21; The expression of miR-21 and PDCD4 was highly correlated with the degree of differentiation tumor staging local lymphatic node metastasis and remote metastasis; In addition the relative expression of PDCD4 was negatively correlated with miR-21; Thus we conclude that ROS promotes gastric carcinogenesis via upregulating miR-21 expression which in turn down-regulates the expression of PDCD4 in gastric cancer cells;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;MicroRNA 21 down regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G; Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G A172 U87 and U251; Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis;Treatment of HSC-3 cells with Nanog- and/or Stat-3-specific small interfering RNAs effectively blocks HA-mediated Nanog-Stat-3 signaling events abrogates miR-21 production and increases PDCD4 expression;Programmed cell death 4 PDCD4 is critical in mediating apoptosis in GBM and is downregulated by miR-21 which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4; This review will focus on the roles of miRNAs family members particularly miR-21 and its target gene PDCD4 in tumors like glioblastoma and new targeting strategies as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies;Using Western blot analysis miR-21 knockdown enhanced the expression of tumor suppressor PDCD4 and attenuated apoptosis inhibitor c-IAP2;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;METHODS 3-45-dimethylthiazol-2-yl-25-diphenyltetrazolium bromide MTT assay was used to determine the effect of 5-FU on the viability of RKO cells with knockout of miR-21 or high expression of PDCD4;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;In this study we analyzed the expression of miR-21 and of its target PDCD4 Programmed Cell Death 4 during normal hematopoietic differentiation and in AMLs;MiR 21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2; In addition miR-21 knockdown increased the expression of endogenous PDCD4 and hMSH2 which contributed to the apoptosis and G2 arrest of T98G cells; The findings suggested that miR-21 may mediate the resistance of glioblastoma cells against radiation via its target genes PDCD4 and hMSH2;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated;The expression of programmed cell death-4 PDCD4 was increased by I3C and reduced by miR-21 transfection; Such enhanced chemosensitivity might be explained by the increased expression of PDCD4 which is a downstream target which miR-21 negatively regulates;It has been reported that miR-21 was upregulated in most malignant cancers the proposed mechanism of which was through suppressing expression of programmed cell death 4 PDCD4; In present study it is firstly reported that miR-21 was upregulated in Kazakh's ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization ISH and luciferase reporter approach;To measure levels of microRNA miR-21 and its target gene programmed cell death 4 PDCD4 in samples of human cutaneous malignant melanoma and normal non-malignant control skin; Relative levels of miR-21 and PDCD4 mRNA were measured using a quantitative real-time reverse transcription-polymerase chain reaction; Compared with normal skin samples the relative level of miR-21 was significantly higher and the relative level of PDCD4 mRNA was significantly lower in the melanoma specimens; A significant negative correlation between PDCD4 mRNA and miR-21 was demonstrated in malignant melanoma r = -0.602; Elevated miR-21 and reduced PDCD4 mRNA levels were both significantly correlated with increased tumour size a higher Clark classification level and the presence of lymph node metastases in malignant melanoma; These findings suggest that miR-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future;MicroRNA 21 and PDCD4 expression in colorectal cancer; Studies have shown that miR-21 exerts its oncogenic activity by targeting the PDCD4 tumour suppressor 3'-UTR; The purpose of this study was to delineate the interaction between PDCD4 and its oncogenic modulator miR-21 in colorectal cancer; A cohort of 48 colorectal tumours 61 normal tissues and 7 polyps were profiled for miR-21 and PDCD4 gene expression; A significant inverse relationship between miR-21 and PDCD4 gene expression p < 0.001 was identified by RT-qPCR; In addition significant reduction of PDCD4 p < 0.001 expression and reciprocal upregulation of miR-21 p = 0.005 in a progressive manner from tumour-polyp-normal mucosae was identified; This study demonstrates the inverse relationship between miR-21 and PDCD4 thus suggesting that miR-21 post-transcriptionally modulates PDCD4 via mRNA degradation;Expression patterns of miR-21 RNA and its target tumor suppressor protein PDCD4 were mutually exclusive;Exosome shuttling microRNA 21 promotes cell migration and invasion targeting PDCD4 in esophageal cancer;The expression of programmed cell death 4 PDCD4 which is a miR-21 targeting apoptotic gene has also been enhanced by UA; And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA;miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR RT-PCR; Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA and miR-155 and TP53INP1 mRNA;The aim of this study was a to determine a role of microRNA-21 in esophageal squamous cell carcinoma and b to elucidate the regulation of the programmed cell death 4 PDCD4 gene by microRNA-21; In addition the regulation of PDCD4 by microRNA-21 was elucidated to identify the mechanisms of this regulation; The PDCD4 protein levels in esophageal squamous cell carcinoma cells have an inverse correlation with microRNA-21 expression; MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma;Maspin Pdcd4 and miR-21 expressions were evaluated by a real-time polymerase chain reaction in 20 endometrial cancer and 10 normal endometrium samples; Comparison between IA and more advanced International Federation of Gynecology and Obstetrics stages of endometrial cancer in regard to expression levels of maspin Pdcd4 and miR-21 did not reveal any significant differences;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Sequence prediction and gene expression regulation assays showed that miR-21 could reversely regulate the expression of PDCD4 P < 0.01; Suppression of miR-21 expression is associated with an elevation of Pdcd4 resulting in a significant reduction of proliferation and the apoptosis rate 2.6% was increased to 10.9%; Moreover the anti-proliferation and pro-apoptotic effect by miR-21 suppression could be reversed by PDCD4 knock down;Downregulation of Pdcd4 by mir 21 facilitates glioblastoma proliferation in vivo; We demonstrate that downregulation of mir-21 in glioblastoma-derived cell lines results in increased expression of its target programmed cell death 4 Pdcd4 a known tumor-suppressor gene; In addition our data indicate that either downregulation of mir-21 or overexpression of its target Pdcd4 in glioblastoma-derived cell lines leads to decreased proliferation increased apoptosis and decreased colony formation in soft agar; Using a glioblastoma xenograft model in immune-deficient nude mice we observe that glioblastoma-derived cell lines in which mir-21 levels are downregulated or Pdcd4 is over-expressed exhibit decreased tumor formation and growth; These critical in vivo findings demonstrate an important functional linkage between mir-21 and Pdcd4 and further elucidate the molecular mechanisms by which the known high level of mir-21 expression in glioblastoma can attribute to tumorigenesis--namely inhibition of Pdcd4 and its tumor-suppressive functions ;;;;;metastasis;;;;;worse prognosis;;staging;;metastasis;;;metastasis;progression;;;;;;poor survival;;;;;metastasis;;metastasis;poor survival;drug resistance;;;drug resistance;;progression;;metastasis;metastasis;staging;;;drug resistance;staging;metastasis;differentiation;tumorigenesis;;;;drug resistance;;;;;;differentiation;drug resistance;;;malignant trasformation;malignant trasformation;metastasis;progression;;cell migration;;;;staging;drug resistance;;tumorigenesis breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;chronic myeloid leukemia;thyroid cancer;colon cancer;colorectal cancer;liver cancer;colon cancer;gastric cancer;liver cancer;retinoblastoma;cervical and endocervical cancer;prostate cancer;lung squamous cell cancer;prostate cancer;colorectal cancer;glioblastoma;thyroid cancer;colon cancer;ovarian cancer;ovarian cancer;kidney renal cell cancer;ovarian cancer;colorectal cancer;liver cancer;esophageal cancer;glioblastoma;lung squamous cell cancer;gastric cancer;kidney renal cell cancer;glioblastoma;colorectal cancer;colorectal cancer;colorectal cancer;lung cancer;prostate cancer;prostate cancer;gastric cancer;B cell lymphoma;glioblastoma;head and neck cancer;glioblastoma;ovarian cancer;liver cancer;colon cancer;gastric cancer;B cell lymphoma;acute myeloid leukemia;glioblastoma;prostate cancer;pancreatic cancer;esophageal cancer;melanoma;colorectal cancer;colorectal cancer;esophageal cancer;glioblastoma;colorectal cancer;esophageal cancer;endometrial cancer;pancreatic cancer;lung squamous cell cancer;glioblastoma hsa-miR-28-5p PDE4A -0.14267073663385 0.0497619246260571 -0.10844696857969 0.381039125696737 miRanda -0.227281107486484 0.000110708900233232 NA NA NA hsa-miR-107 PDE9A 0.678998026350662 2.56224148930538e-16 -1.6382578179967 2.63013010244279e-23 miRanda -0.142724491776297 0.039563526928395 NA NA NA hsa-miR-338-3p PDE9A 0.0799903526884966 0.575137668326679 -1.6382578179967 2.63013010244279e-23 miRanda -0.125429579667911 0.00207738923970445 NA NA NA hsa-miR-125a-3p PDGFD -0.176412960953959 0.10108079286419 -2.17788738091168 7.06207148591019e-60 miRanda -0.119583380809276 0.00952184976958956 NA NA NA hsa-miR-320b PDGFD 0.412787504747938 0.00113457276903985 -2.17788738091168 7.06207148591019e-60 miRanda -0.234603273416289 1.42000791647672e-09 NA NA NA hsa-miR-590-3p PDGFD 1.27438512890514 1.03164723481469e-23 -2.17788738091168 7.06207148591019e-60 miRanda -0.499606568060295 3.79285218268692e-40 NA NA NA hsa-miR-590-5p PDGFD 0.746515607868274 8.51300479640125e-09 -2.17788738091168 7.06207148591019e-60 miRanda -0.454069225558139 4.11350350024471e-36 NA NA NA hsa-miR-193a-3p PDGFRA 0.310617999804917 0.00477640270974957 -1.84169721584144 2.50038285124215e-31 miRanda -0.236933469215575 3.5076412689528e-06 NA NA NA hsa-miR-320b PDGFRA 0.412787504747938 0.00113457276903985 -1.84169721584144 2.50038285124215e-31 miRanda -0.183733564050286 3.69207458785768e-05 NA NA NA hsa-miR-330-5p PDGFRA 0.626063225953928 3.42215028606779e-09 -1.84169721584144 2.50038285124215e-31 miRanda -0.192776801359275 0.000261739400977773 NA NA NA hsa-miR-338-3p PDGFRA 0.0799903526884966 0.575137668326679 -1.84169721584144 2.50038285124215e-31 miRanda -0.319924077772208 1.84779948590881e-16 NA NA NA hsa-miR-339-5p PDGFRA -0.211548290465418 0.0685885445822389 -1.84169721584144 2.50038285124215e-31 miRanda -0.18956471906179 9.38243938310758e-05 NA NA NA hsa-miR-342-3p PDGFRA 1.21944481975657 6.81914373001202e-19 -1.84169721584144 2.50038285124215e-31 miRanda -0.370862046281642 3.2391388940783e-21 NA NA NA hsa-miR-34a-5p PDGFRA 0.129201805242403 0.133261654068224 -1.84169721584144 2.50038285124215e-31 miRTarBase -0.257308196495663 9.23678964579895e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-429 PDGFRA 2.84108892259147 3.88520896426515e-64 -1.84169721584144 2.50038285124215e-31 miRanda -0.373691764862624 4.97896969778458e-36 NA NA NA hsa-miR-590-3p PDGFRA 1.27438512890514 1.03164723481469e-23 -1.84169721584144 2.50038285124215e-31 miRanda -0.264364229545702 3.69842178603011e-09 NA NA NA hsa-miR-590-5p PDGFRA 0.746515607868274 8.51300479640125e-09 -1.84169721584144 2.50038285124215e-31 miRanda -0.212109048295796 7.97276608700393e-07 NA NA NA hsa-miR-28-5p PDGFRB -0.14267073663385 0.0497619246260571 -0.363053423609744 0.000930448280520273 miRanda -0.106080049561343 0.0428915822633876 NA NA NA hsa-miR-107 PDK4 0.678998026350662 2.56224148930538e-16 -3.89935179730226 5.03724845925338e-73 miRanda -0.606482325095186 2.50660449655034e-10 NA NA NA hsa-miR-142-3p PDK4 1.53951237846104 2.06769936282034e-17 -3.89935179730226 5.03724845925338e-73 miRanda -0.326055304790836 4.43256561958048e-14 NA NA NA hsa-miR-146b-5p PDK4 0.631041661167954 6.20366593452965e-08 -3.89935179730226 5.03724845925338e-73 miRanda -0.186486111980283 0.00707653939025631 NA NA NA hsa-miR-429 PDK4 2.84108892259147 3.88520896426515e-64 -3.89935179730226 5.03724845925338e-73 miRanda -0.567070392199625 2.867364355147e-40 NA NA NA hsa-miR-455-5p PDK4 0.284641224662773 0.0357572339594277 -3.89935179730226 5.03724845925338e-73 miRanda -0.212147341084509 0.000393289565324974 NA NA NA hsa-miR-590-3p PDK4 1.27438512890514 1.03164723481469e-23 -3.89935179730226 5.03724845925338e-73 miRanda -0.706122338938632 2.67385440127086e-29 NA NA NA hsa-miR-155-5p PDLIM5 1.09766314984151 4.55650930885814e-15 -0.386783087716429 0.000421349445583799 miRTarBase -0.134753633786121 3.11438755790732e-07 NA NA NA hsa-miR-28-5p PDXDC1 -0.14267073663385 0.0497619246260571 0.867679818835133 1.64124821154065e-33 miRanda -0.20421343833345 7.92479068630763e-09 NA NA NA hsa-miR-590-3p PEG3 1.27438512890514 1.03164723481469e-23 -1.76855555357171 1.41302613452224e-11 miRanda -0.206661734246392 0.00456269665131643 NA NA NA hsa-miR-429 PENK 2.84108892259147 3.88520896426515e-64 -3.86605725361397 1.18837424026093e-41 miRanda -0.574662736412717 3.54270221443008e-25 NA NA NA hsa-miR-28-5p PEX12 -0.14267073663385 0.0497619246260571 -0.244701247391237 0.00249870618819211 miRanda -0.269940810394297 1.38504482563852e-12 NA NA NA hsa-miR-28-5p PFKM -0.14267073663385 0.0497619246260571 -0.167575311099228 0.0685593901261937 miRanda -0.116393774331497 0.00788145315345331 NA NA NA hsa-miR-28-5p PHKB -0.14267073663385 0.0497619246260571 -0.474811813850328 3.42461136633396e-10 miRanda -0.111196268170306 0.0022176267680483 NA NA NA hsa-miR-28-5p PHKG2 -0.14267073663385 0.0497619246260571 1.17584598160819 7.15388386958662e-52 miRanda -0.201461578928291 2.7542518948257e-07 NA NA NA hsa-miR-375 PHYHIPL 2.09893673049766 1.68351780396203e-16 -2.11508828895346 7.32933510596028e-24 miRanda -0.173476534584885 8.33024866112958e-10 NA NA NA hsa-miR-28-5p PIGG -0.14267073663385 0.0497619246260571 0.107993711309021 0.0641318638666071 miRanda -0.156799939519724 1.20811913049496e-08 NA NA NA hsa-miR-28-5p PIGO -0.14267073663385 0.0497619246260571 0.632201925119523 4.99557211163621e-21 miRanda -0.189309260037223 5.74895962733358e-09 NA NA NA hsa-miR-28-5p PIK3R2 -0.14267073663385 0.0497619246260571 1.28293433832686 8.5972816204378e-73 miRanda -0.170225138245223 4.06181677270291e-06 NA NA NA hsa-miR-28-5p PIK3R3 -0.14267073663385 0.0497619246260571 0.559172960265555 3.98014986716526e-09 miRanda -0.112036735701901 0.0141687305542462 NA NA NA hsa-miR-590-3p PIP 1.27438512890514 1.03164723481469e-23 -1.9955079711554 0.00010373264442386 miRanda -1.06417039003399 2.66049274415734e-14 NA NA NA hsa-miR-28-5p PIP4K2C -0.14267073663385 0.0497619246260571 0.785545156337934 1.33112420136684e-29 miRanda -0.201400552827145 3.19497519827677e-09 NA NA NA hsa-miR-375 PLAG1 2.09893673049766 1.68351780396203e-16 -1.22970054692881 5.65960696224232e-15 miRTarBase -0.159268648639397 1.93878849620109e-14 NA NA NA hsa-miR-21-5p PLAT 2.32007501846389 3.08394781855554e-137 -0.702112551655769 9.14307616771267e-05 miRTarBase -0.15220333311024 0.00672105587093083 19308091 We also demonstrated that both deltaEF1 and TPA induced miR-21 expression breast cancer hsa-miR-28-5p PLCD4 -0.14267073663385 0.0497619246260571 0.135354827465335 0.311825654751022 miRanda -0.503044438055499 9.77066808847889e-16 NA NA NA hsa-miR-375 PLCH1 2.09893673049766 1.68351780396203e-16 -0.404982696404933 0.181998504172079 miRanda -0.24246295657848 9.86687480085553e-10 NA NA NA hsa-miR-375 PLD5 2.09893673049766 1.68351780396203e-16 -3.60457806400539 7.30122052927803e-48 miRanda -0.187809454046636 5.33370273502768e-08 NA NA NA hsa-miR-28-5p PLEKHH1 -0.14267073663385 0.0497619246260571 -0.261980470817113 0.0364210745908391 miRanda -0.142488673730933 0.0169848340831966 NA NA NA hsa-miR-193a-3p PLIN1 0.310617999804917 0.00477640270974957 -6.2622073950094 6.60051883053958e-72 miRanda -0.461742015204803 0.000105779627620596 NA NA NA hsa-miR-330-5p PLIN1 0.626063225953928 3.42215028606779e-09 -6.2622073950094 6.60051883053958e-72 miRanda -0.967791110162886 1.3212285501913e-15 NA NA NA hsa-miR-590-5p PLIN1 0.746515607868274 8.51300479640125e-09 -6.2622073950094 6.60051883053958e-72 miRanda -0.971471197441056 3.1672983907582e-23 NA NA NA hsa-miR-28-5p PMPCA -0.14267073663385 0.0497619246260571 0.52698682555574 5.78301134193271e-17 miRanda -0.119185297110825 9.09650178789744e-05 NA NA NA hsa-miR-21-5p PPARA 2.32007501846389 3.08394781855554e-137 -1.66915873925688 2.97363179285551e-46 miRTarBase -0.499807555240057 2.55196074428291e-42 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-130b-3p PPARG 1.38122163823846 1.00932179737836e-26 -3.26817991841726 8.75586156961703e-92 miRTarBase -0.398938669721766 3.34872217424201e-18 NA NA NA hsa-miR-142-3p PPARG 1.53951237846104 2.06769936282034e-17 -3.26817991841726 8.75586156961703e-92 miRanda -0.181266887317845 4.93206896980757e-08 NA NA NA hsa-miR-20a-5p PPARG 0.44979911120222 0.000602386964327228 -3.26817991841726 8.75586156961703e-92 miRTarBase -0.256226691573231 4.58714508624804e-08 NA NA NA hsa-miR-324-5p PPARG 0.211552647440779 0.139408130311654 -3.26817991841726 8.75586156961703e-92 miRanda -0.199962416853761 3.55800966795728e-06 NA NA NA hsa-miR-590-3p PPARG 1.27438512890514 1.03164723481469e-23 -3.26817991841726 8.75586156961703e-92 miRanda -0.404612570573574 1.0703640637196e-16 NA NA NA hsa-miR-375 PPARGC1A 2.09893673049766 1.68351780396203e-16 -2.61634087589818 7.44821426380706e-32 miRanda -0.203571434468169 1.64340091775123e-11 NA NA NA hsa-miR-28-5p PPIP5K1 -0.14267073663385 0.0497619246260571 -0.194364800594986 0.0237079880541731 miRanda -0.314004798274111 6.46576353569024e-15 NA NA NA hsa-miR-28-5p PPOX -0.14267073663385 0.0497619246260571 0.830291250171679 6.58170304361639e-23 miRanda -0.169004189934174 3.92854986223783e-05 NA NA NA hsa-miR-320b PPP1R12B 0.412787504747938 0.00113457276903985 -2.23500813943069 2.60349931631869e-111 miRanda -0.127338339760324 4.12415259454622e-05 NA NA NA hsa-miR-590-3p PPP1R12B 1.27438512890514 1.03164723481469e-23 -2.23500813943069 2.60349931631869e-111 miRanda -0.304756341354479 3.00745144127225e-23 NA NA NA hsa-miR-28-5p PPP1R14D -0.14267073663385 0.0497619246260571 1.08406784337159 4.61757779337715e-07 miRanda -0.688171627902918 1.5008747175405e-11 NA NA NA hsa-miR-338-3p PPP1R1A 0.0799903526884966 0.575137668326679 -4.76989601631288 8.28796248346058e-54 miRanda -0.240203130745838 0.00252207195636103 NA NA NA hsa-miR-146b-5p PPP2R1B 0.631041661167954 6.20366593452965e-08 -1.24069690315388 3.45729939213988e-47 miRanda -0.141184532696467 1.00140046078863e-07 NA NA NA hsa-miR-429 PPP2R1B 2.84108892259147 3.88520896426515e-64 -1.24069690315388 3.45729939213988e-47 miRanda -0.148415458438853 1.78268855237664e-18 NA NA NA hsa-miR-28-5p PREPL -0.14267073663385 0.0497619246260571 -0.322293281183161 8.79993670730062e-06 miRanda -0.11687031971652 0.000735961886475128 NA NA NA hsa-miR-375 PRKD1 2.09893673049766 1.68351780396203e-16 -1.79496662198383 1.13842611279171e-44 miRanda -0.105612854713499 2.4604331853682e-09 NA NA NA hsa-miR-375 PRKX 2.09893673049766 1.68351780396203e-16 -0.32229806441307 0.0153896096972611 miRanda -0.207392873270567 7.07421795114455e-35 NA NA NA hsa-miR-28-5p PROM2 -0.14267073663385 0.0497619246260571 1.56071419150459 1.77985184998625e-25 miRanda -0.346665083892436 2.17099288160034e-06 NA NA NA hsa-miR-375 PROS1 2.09893673049766 1.68351780396203e-16 -2.19756827330153 2.03994096685545e-66 miRanda -0.152079888688611 2.61155429473572e-17 NA NA NA hsa-miR-28-5p PRR5-ARHGAP8 -0.14267073663385 0.0497619246260571 1.48757303661783 5.00986879889586e-23 miRanda -0.204597767552065 0.00551521866120443 NA NA NA hsa-miR-375 PTCH1 2.09893673049766 1.68351780396203e-16 -1.99144733451091 8.8131310666777e-41 miRanda -0.182234588300658 2.0897729520062e-19 NA NA NA hsa-miR-21-5p PTEN 2.32007501846389 3.08394781855554e-137 -0.737945156702629 1.26474514880987e-22 miRTarBase -0.241962926381789 5.21884080644212e-25 26387181;21471222;26905520;25027758;21820606;24930006;22547075;26666820;23951172;25647415;22678116;22832383;19212625;22267008;26384051;22322462;27644439;21468550;20113523;21806946;24154840;27611950;24780321;23036707;23684551;26559642;26731559;26847601;27350731;24331411;25909227;24293118;26289851;24324076;23201752;17681183;25963606;27188433;22958183;22956424;19730150;21842656;21104017;23894315;23548551;26236156;24460329;20092645;25973032;25563770;24659669;26230405;25543482;20048743;27725205;23466500;22922228;25058005;20223231;27220494;24763002;24221338;22120473;21408027;23174819;22978663;25799148;26741162;23226804;26787105;26864640;26311740;25603978;26975392 In addition treated with 5-AZA resulted in significant increases of miR-21 expression in both MCF-7 and MDA-MB-231 cells P < 0.01 with the protein level of PTEN increased in MCF-7 cell which was further involved in the downregulation of AKT;Here we demonstrated that miR-21 expression was up-regulated and its function was elevated in HER2+ BT474 SKBR3 and MDA-MB-453 breast cancer cells that are induced to acquire trastuzumab resistance by long-term exposure to the antibody whereas protein expression of the PTEN gene a miR-21 target was reduced; Rescuing PTEN expression with a p3XFLAG-PTEN-mut construct with deleted miR-21 targeting sequence at its 3' UTR restored the growth inhibition of trastuzumab in the resistant cells by inducing PTEN activation and AKT inhibition; In vivo administering miR-21 antisense oligonucleotides restored trastuzumab sensitivity in the resistant breast cancer xenografts by inducing PTEN expression whereas injection of miR-21 mimics conferred trastuzumab resistant in the sensitive breast tumors via PTEN silence;The effect of ZA on miR-21 expression was quantified by qRT-PCR and the amount of PTEN protein and its targets were analyzed by Western blot;In the same patients we also compared miR-21 expression with the expression of its presumed target PTEN; miR-21 expression levels were found to significantly correlate with tumour size r = 0.403 p = 0.009; Spearman's rank whereas no relation was found between miR-21 and PTEN expression levels Kruskal-Wallis test;MicroRNA 21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN; TaqMan RT-PCR or Western blot assay was performed to detect the expression of mature miR-21 and tumor suppressor gene PTEN protein; We showed that upregulation of miR-21 in MCF-7/ADR cells was concurrent with downregulation of PTEN protein; Overexpression of PTEN could mimic the same effects of miR-21 inhibitor in MCF-7/ADR cells and PTEN-siRNA could increase the resistance of MCF-7 cells to ADR; MiR-21 inhibitor could increase PTEN protein expression and the luciferase activity of a PTEN 3' untranslated region-based reporter construct in MCF-7/ADR cells; Dysregulation of miR-21 plays critical roles in the ADR resistance of breast cancer at least in part via targeting PTEN;In present study we determined the miR-21 levels in TNBC specimens and TNBC cell levels in vitro and then identified the role of miR-21 on tumor cell proliferation apoptosis and then identified PTEN as the possible target of the microRNA;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;PTEN a direct target gene of miR-21 was significantly downregulated in gemcitabine-resistant breast cancer cells and restoration of PTEN expression blocked miR-21-induced EMT and gemcitabine resistance;The results showed that knockdown of miR-21 by antagomir-21 decreased cell proliferation and induced apoptosis via targeting PTEN both in 4T1 cells and HUVECs;MiR-21 upregulation contributes to PTEN downregulation which is beneficial for the activation of PI3K/AKT signaling;Furthermore miR-21-induced upregulation of CSF-1 mRNA and its transcription were prevented by expression of PTEN mRNA lacking 3'-untranslated region UTR and miR-21 recognition sequence; Our results reveal a novel mechanism for the therapeutic function of fish oil diet that blocks miR-21 thereby increasing PTEN levels to prevent expression of CSF-1 in breast cancer;After miR-21 was transfected in MCF-7 cells PTEN protein level was measured by Western blot; Matrine up-regulated PTEN by downregulating miR-21 which in turn dephosphorylated Akt resulting in accumulation of Bad p21/WAF1/CIP1 and p27/KIP1;To further determine the potential involvement of miR-21 in breast cancer we have evaluated the expression level of miR-21 by stem-loop real-time RT-PCR based on SYBR-Green I in human invasive ductal carcinoma of the breast and we have correlated the results with clinicopathologic features and PTEN protein expression; The expression levels of miR-21 were correlated with PTEN and commonly used clinicopathologic features of breast cancer; Expression of miR-21 was negatively correlated with expression of PTEN P=0.013; These findings suggest that PTEN is possibly one of the targets of miR-21 in breast cancer and high expression of mir-21 indicates a more aggressive phenotype;microRNA 21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN; Thus in this study we focused on the expression and significance of miR-21 in gastric cancer tissues and the role of miR-21 in the biological behaviour and the expression of PTEN in gastric cancer cells; Western blotting and the Luciferase Reporter Assay were used to evaluate the change of PTEN expression after lowered expression of miR-21 in gastric cancer cell lines; The western blot results and Luciferase Reporter Assay demonstrated that PTEN expression was remarkably increased after miR-21 inhibition P<0.05 microRNA-21 expression was upregulated in gastric carcinoma tissues and was significantly associated with the degree of differentiation of tumour tissues local invasion and lymph node metastasis;Furthermore we identified that miR-21 overexpression could promote Hela and U2OS cells proliferation by targeting phosphatase-tensin homolog PTEN the result of which can be rescued by miR-21 inhibitor;Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon;Bmi-1 also regulates p53 and PTEN via miR-21;The expression of miR-21 and its target PTEN was determined by real-time qRT-PCR and western blotting respectively in tumor tissues as well as adjacent non-tumor mucosa; miR-21 was significantly up-regulated in tumor tissues while PTEN was expressed in lower levels compared to non-tumor tissues; A negative correlation between expression of miR-21 and PTEN was established in vivo;MicroRNA 21 inhibitor sensitizes human glioblastoma cells U251 PTEN mutant and LN229 PTEN wild type to taxol; Human glioblastoma U251 PTEN-mutant and LN229 PTEN wild-type cells were treated with taxol and the miR-21 inhibitor in a poly amidoamine PAMAM dendrimer alone or in combination; Interestingly the above data suggested that in both the PTEN mutant and the wild-type GBM cells miR-21 blockage increased the chemosensitivity to taxol; Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;NTR1 activation stimulates expression of miR-21 and miR-155 in colonocytes via Akt and NF-κB to down-regulate PTEN and SOCS1 and promote growth of tumors in mice;Correlations between the expression levels of miR-21 PTEN and p-AKT were analyzed by real-time PCR and Western blot test in HER2-positive GC cell lines; Overexpression of miR-21 down-regulated PTEN expression increased AKT phosphorylation and did not affect HER2 expression; Inversely suppression of miR-21 increased PTEN expression and down-regulated AKT phosphorylation but still did not affect HER2 expression;MicroRNA 21 promotes TGF β1 induced epithelial mesenchymal transition in gastric cancer through up regulating PTEN expression; In GC tissues the expressions of miR-21 Akt and p-Akt were up-regulated while PTEN expression was down-regulated; These results suggest that miR-21 could promote TGF-β1-induced EMT in GC cells through up-regulating PTEN expression;Expressions of PTEN were significantly down-regulated in CRC tissues and negatively correlated with expressions of Notch-1 r2=0.5207 p<0.01 and miR-21 r2=0.6996 p<0.01; These data indicate that the crosstalk between Notch-1 and miR-21 is involved in CRC development through degradation of PTEN;Over-expression of miR-21 suppressed its target PTEN and disrupted acinar morphogenesis;MicroRNA 21 suppresses PTEN and hSulf 1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways;There was overexpression of the miR-21 target genes PTEN by 67% and caspase-3 by 15% upon cotreatment;We previously reported that microRNA-21 miR-21 was strongly expressed in melanoma relative to naevi and now sought to further assess the significance of this by assessing its relationship with its putative target PTEN; Clinical melanoma samples were analysed by immunohistochemical analysis for PTEN stem-loop qRT-PCR for miR-21 and PCR for BRAF/NRAS mutation status; miR-21 expression was inversely associated with nuclear PTEN expression but not with cytoplasmic PTEN expression; These data suggest miR-21 may exert an oncogenic effect in melanoma by favouring redistribution of PTEN to the nucleus;Triptolide reduces proliferation and enhances apoptosis of human non small cell lung cancer cells through PTEN by targeting miR 21; To the best of our knowledge the present study is the first to demonstrate that triptolide reduced the proliferation and enhanced the apoptosis of human NSCLC cells through PTEN by targeting miR-21;Quantitative real-time PCR qRT-PCR and Western blot were used to detect the expression levels of miR-21 and PTEN in HCT116 HT29 Colo32 and SW480 CRC cell lines; Also the expression levels of PTEN mRNA and its downstream proteins AKT and PI3K in HCT116 cells after downregulating miR-21 were investigated; In comparing the levels of PTEN protein and downstream AKT and PI3K in HCT116 cells after downregulation of miR-21 expression the levels of AKT and PI3K protein expression significantly decreased P < 0.05; PTEN is one of the direct target genes of miR-21;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;MiR-21 level was inversely correlated with the levels of FOXO1 and PTEN in DLBCL cell lines; MiR-21 also down-regulated PTEN expression and consequently activated the PI3K/AKT/mTOR pathway which further decreased FOXO1 expression;MiR 21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non small cell lung cancer A549 cells; Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA was performed to modulate the expression of microRNA-21 and PTEN under the treatment of curcumin; Moreover the protein level of PTEN a putative target of microRNA-21 was significantly elevated in curcumin-treated A549 cells as determined by Western blot analysis; Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA significantly P < 0.05 reversed the growth suppression and apoptosis induction by curcumin compared to corresponding controls; Our data suggest a novel molecular mechanism in which inhibition of microRNA-21 and upregulation of PTEN mediate the anticancer activities of curcumin in NSCLC cells;PTEN gene expression was performed as a known target of miR-21;We also found that Rawq01 up-regulated the expression of PTEN through mir-21 inhibition and therefore inhibited the PI3K-AKT pathway;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;MicroRNA 21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer; PTEN was shown to be a direct target of miR-21 and to contribute to miR-21 effects on cell invasion; Modulation of miR-21 altered focal adhesion kinase phosphorylation and expression of matrix metalloproteases 2 and 9 both downstream mediators of PTEN involved in cell migration and invasion; Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth migration and invasion;Overexpression of miR 21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN; The aim of this study was to examine the expression of miR-21 and PTEN in cervical cancer specimens using quantitative PCR; miR-21 was upregulated in the cervical cancer specimens negatively correlating with the PTEN mRNA level; Transfection of the miR-21 mimics was markedly promoted whereas the miR-21 inhibitor suppressed the proliferation migration and invasion of cervical cancer cells with a significant inhibition of PTEN expression; The present study showed the upregulation of miR-21 in invasive cervical cancers and confirmed the promotion of miR-21 with regard to the proliferation migration and invasion in cervical cancer cells via inhibiting the PTEN expression;The expressions of miR-21 PTEN PI3K and AKT were detected in 89 esophageal cancer samples and 58 adjacent normal tissues respectively; MiR-21 PI3K and AKT have higher expressions but PTEN has lower expression in esophageal cancer tissues compared with adjacent normal tissues; Further PTEN was a target gene of miR-21;The expression level of miR-21 and PTEN messenger RNA were measured by quantitative real-time reverse transcription polymerase chain reaction or reverse transcription polymerase chain reaction; miR-21 was overexpressed and PTEN was suppressed in established radioresistant TE-R60 cells compared with the parent cells 1.3-fold and 70.83%; The inhibition of miR-21 significantly increased the cells' radiosensitivity P < 0.05 and the PTEN protein expression 2.3-fold in TE-1 cells; Knockdown of PTEN in anti-miR-21 TE-1 cells could abrogate the miR-21 inhibition-induced radiosensitization P < 0.05; Inhibition of miR-21 increased radiosensitivity of esophageal cancer TE-1 cells and this effect was possibly through the activation of PTEN;MicroRNA 21 miR 21 expression promotes growth metastasis and chemo or radioresistance in non small cell lung cancer cells by targeting PTEN; Taken together these results provide evidence to show the promotion role of miR-21 in NSCLC development through modulation of the PTEN signaling pathway;Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Role of microRNA 21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma; To evaluate the role of miR-21 and PTEN cell proliferations were analyzed with miR-21 mimics or their inhibitor-transfected cells; In Eca109 when transfected with miR-21 mimics accumulation of miR-21 was obviously increased and expression of PTEN protein was decreased to be approximately 40% which resulted in the promotion of cell proliferation; However when transfected with miR-21 inhibitor expression of miR-21 was declined and PTEN protein was overexpressed to be approximately 79% which resulted in the suppression of cell proliferation; Furthermore there was a significantly inverse correlation between miR-21 expression and PTEN protein levels p < 0.05; The author concluded that MiR-21 was overexpressed in vitro and ESCC and promoted the cell proliferation might target PTEN at post-transcriptional level and regulated the cancer invasion in Kazakh's ESCC;Difluorinated curcumin CDF restores PTEN expression in colon cancer cells by down regulating miR 21; Indeed our current data demonstrate a marked downregulation of PTEN in SCID mice xenografts of miR-21 over-expressing colon cancer HCT116 cells; Colonospheres that are highly enriched in cancer stem/stem like cells reveal increased miR-21 expression and decreased PTEN; Difluorinated curcumin CDF a novel analog of the dietary ingredient curcumin which has been shown to inhibit the growth of 5-Flurouracil + Oxaliplatin resistant colon cancer cells downregulated miR-21 in chemo-resistant colon cancer HCT116 and HT-29 cells and restored PTEN levels with subsequent reduction in Akt phosphorylation;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;Mechanistic evidence showed that down-regulation of miR-21 increased the expression of its target molecule PTEN in HCT116 cells;Finally invasion and metastasis assays were performed and alteration in mir-21 PTEN AKT and pAKT level was evaluated in these cells; Enhanced invasion and metastasis increased miR-21 expression decreased PTEN elevated pAKT level were demonstrated in gemcitabine-resistant HPAC and PANC-1 cells;In the present study we investigated the role of miR-21 and its potential as a therapeutic target in two prostate cancer cell lines characterized by different miR-21 expression levels and PTEN gene status;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;Expressions of microRNA-21 miR-21 PTEN MMP9 and p47 were detected by qPCR;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;microRNA 21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder Cancer; MicroRNA-21 regulates proliferation and migration of bladder cancer cells and cross talk with PTEN and p53 in bladder cancer;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status; To explore whether miR-21 can serve as a therapeutic target for glioblastoma we downregulated miR-21 with a specific antisense oligonucleotide and found that apoptosis was induced and cell-cycle progression was inhibited in vitro in U251 PTEN mutant and LN229 PTEN wild-type GBM cells; xenograft tumors from antisense-treated U251 cells were suppressed in vivo; Taken together our studies provide evidence that miR-21 may serve as a novel therapeutic target for malignant gliomas independent of PTEN status;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated; In conclusion our data suggest that mUA can suppress cell viability in DU145 cells through modulating miR-21 and its downstream series-wound targets including PTEN Akt and Wnt/β-catenin signaling;miR 21 confers cisplatin resistance in gastric cancer cells by regulating PTEN; In addition miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 PTEN and activation of Akt pathway;Finally we demonstrate that modulation of tumor suppressors PTEN and p53 in U87 cells does not affect the decrease in miR-21 levels associated with PDGF-B overexpression;This study aimed to investigate whether NSCLC miR-21 mediated resistance to TKIs also results from Pten targeting; Here we show miR-21 promotes cancer by negatively regulating Pten expression in human NSCLC tissues: high miR-21 expression levels were associated with shorter DFS in 47 NSCLC patients; high miR-21/low Pten expression levels indicated a poor TKI clinical response and shorter overall survival in another 46 NSCLC patients undergoing TKI treatment; In vitro assays showed that miR-21 was up-regulated concomitantly to down-regulation of Pten in pc-9/GR cells in comparison with pc-9 cells; Moreover over-expression of miR-21 significantly decreased gefitinib sensitivity by down-regulating Pten expression and activating Akt and ERK pathways in pc-9 cells while miR-21 knockdown dramatically restored gefitinib sensitivity of pc-9/GR cells by up-regulation of Pten expression and inactivation of AKT and ERK pathways in vivo and in vitro;MicroRNA 21 miR 21 represses tumor suppressor PTEN and promotes growth and invasion in non small cell lung cancer NSCLC; We identified the role of miR-21 in non-small cell lung cancer NSCLC and to clarify the regulation of PTEN by miR-21 and determine mechanisms of this regulation; Expression of miR-21 and PTEN in 20 paired NSCLC and adjacent non-tumor lung tissues was investigated by qRT-PCR and western blot respectively; Tumor tissues showed an inverse correlation between miR-21 and PTEN protein; miR-21 inhibitor transfection increased a luciferase-reporter activity containing the PTEN-3'-UTR construct and increased PTEN protein but not PTEN-mRNA levels in NSCLC cell lines; miR-21 post-transcriptionally down-regulates the expression of tumor suppressor PTEN and stimulates growth and invasion in NSCLC;MiR-21 overexpression decreases PTEN increases p-Akt and subsequently increases HIF-1α expression while miR-21 inhibition results in increased PTEN decreased p-Akt and then decreased HIF-1α;This study was aimed to investigate the expression of microRNA-21 and its correlation with PTEN in diffuse large B cell lymphoma DLBCL paraffin-embedded tissues and evaluate its potential relevance with clinical characteristics; In patients with DLBCL the expression level of miR-21 was negatively correlated with the level of PTEN protein; These findings suggest that PTEN is possibly one of the targets of miR-21 in DLBCL;Down regulation of PTEN expression modulated by dysregulated miR 21 contributes to the progression of esophageal cancer; We demonstrated that knockdown of miR-21 significantly increased expression of PTEN protein; Our findings suggest that miR-21 could be a potential oncomiR probably by regulation of PTEN and a novel prognostic factor for ESCC patients;The levels of mir-21 did not associate with the expression of PTEN an important tumour suppressor in CRC and one of many putative targets of miR-21 but interestingly was associated with stage of disease in the PTEN expressing tumours;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants;The PTEN protein levels in CRC tissues and cells had an inverse correlation with miR-21 expression; MiR-21 targets PTEN at the post-transcriptional level and regulates cell proliferation and invasion in CRC;These findings demonstrate a novel role of AR in the regulation of miR-21 and its target PTEN in growth factor-induced colon cancer cell growth;Whether miR-21 regulated PTEN expression was assessed by luciferase assay; The RNA and protein levels of PTEN were significantly decreased by exogenous miR-21 and the 3'-untranslated region of PTEN was shown to be a target of miR-21;In vitro study showed QTsome/AM-21 induced upregulation of miR-21 targets including PTEN and DDAH1 in A549 cells while increasing their sensitivity toward paclitaxel PTX;microRNA 21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer; We performed a qRT-PCR assay with miR-21 and PTEN in 16 paired EEC tumor tissues and adjacent non-tumor endometrium; To validate the putative binding site of miR-21 in the 3' untranslated region 3'-UTR of PTEN messenger RNA mRNA a dual-luciferase reporter assay was carried out; The upregulation of miR-21 led to a significant decrease in the PTEN protein expression level P=0.007; The downregulation of miR-21 led to a significant increase in PTEN protein P=0.002; In conclusion we demonstrated that the expression of PTEN protein but not mRNA was negatively directly regulated by miR-21 in the KLE cell line; The overexpression of miR-21 modulated EEC cell proliferation through the downregulation of PTEN;The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR 21 and promoter methylation; In this study we investigated the effect of miR-21 and promoter methylation on the PTEN expression status in CRC tissues and analyzed association of the PTEN expression status with clinicopathological features in patients with CRC; PTEN mRNA level was negatively correlated with miR-21 level r = -0.595 P < 0.001; PTEN expression was also correlated directly with the PTEN mRNA level r = 0.583 P < 0.001 and conversely with miR-21 level r = -0.632 P < 0.001; This study suggests a high frequency of miR-21 overexpression and aberrant promoter methylation in down-regulation of PTEN expression in colorectal carcinoma;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Exposure of HCC cells to sorafenib led to an increase in miR-21 expression a decrease in PTEN expression and sequential Akt activation;MicroRNA 21 controls hTERT via PTEN in human colorectal cancer cell proliferation; The aim of this study was to determine a role of microRNA-21 miRNA-21 in colorectal cancer CRC and to elucidate miRNA-21 regulation of hTERT by phosphatase and tensin homologue PTEN;Relevance of miR 21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells; We identified the tumor suppressor gene PTEN as a target of miR-21 and determined the mechanism of its regulation throughout reporter construct plasmids; Using this model we analyzed the expression of miR-21 and PTEN as well as functional effects such as autophagy and apoptosis induction; In SiHa cells there was an inverse correlation between miR-21 expression and PTEN mRNA level as well as PTEN protein expression in cervical cancer cells; We conclude that miR-21 post-transcriptionally down-regulates the expression of PTEN to promote cell proliferation and cervical cancer cell survival ;drug resistance;;;drug resistance;;;drug resistance;;;;;;metastasis;differentiation;;tumorigenesis;;;;;;;;;progression;;;;;drug resistance;;;;;;cell migration;;;;metastasis;drug resistance;;;;;;;metastasis;;;;;;;progression;malignant trasformation;;drug resistance;poor survival;;drug resistance;poor survival;;;;progression;staging;;;;;;;;drug resistance;;;poor survival breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;breast cancer;gastric cancer;cervical and endocervical cancer;colon cancer;gastric cancer;bladder cancer;glioblastoma;colon cancer;gastric cancer;gastric cancer;colorectal cancer;lung cancer;liver cancer;glioblastoma;melanoma;lung squamous cell cancer;colorectal cancer;lung squamous cell cancer;B cell lymphoma;lung squamous cell cancer;thyroid cancer;esophageal cancer;glioblastoma;liver cancer;cervical and endocervical cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;pancreatic cancer;lung cancer;esophageal cancer;colon cancer;B cell lymphoma;colon cancer;pancreatic cancer;prostate cancer;liver cancer;lung cancer;gastric cancer;bladder cancer;B cell lymphoma;glioblastoma;prostate cancer;gastric cancer;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;cervical and endocervical cancer;B cell lymphoma;esophageal cancer;colorectal cancer;pancreatic cancer;colorectal cancer;colon cancer;lung squamous cell cancer;lung cancer;endometrial cancer;colorectal cancer;pancreatic cancer;liver cancer;colorectal cancer;cervical and endocervical cancer hsa-miR-28-5p PTER -0.14267073663385 0.0497619246260571 -0.191994453096763 0.0246991311855573 miRanda -0.133337486918225 0.00104206341060228 NA NA NA hsa-miR-28-5p PTGER3 -0.14267073663385 0.0497619246260571 -2.08536199219359 1.19288336263977e-20 miRanda -0.536055938428695 8.25873008564214e-07 NA NA NA hsa-miR-375 PTH2R 2.09893673049766 1.68351780396203e-16 -2.178747497059 1.48830289461757e-20 miRanda -0.136435813383783 1.56716759666158e-05 NA NA NA hsa-miR-107 PTN 0.678998026350662 2.56224148930538e-16 -2.83408953136008 8.3442187503779e-35 miRanda -0.864569735667178 2.66084935844488e-19 NA NA NA hsa-miR-338-3p PTN 0.0799903526884966 0.575137668326679 -2.83408953136008 8.3442187503779e-35 miRanda -0.178355803760398 0.00204257883066436 NA NA NA hsa-miR-590-3p PTN 1.27438512890514 1.03164723481469e-23 -2.83408953136008 8.3442187503779e-35 miRanda -0.618439129783836 8.81088219772703e-22 NA NA NA hsa-miR-590-5p PTN 0.746515607868274 8.51300479640125e-09 -2.83408953136008 8.3442187503779e-35 miRanda -0.564242995113499 6.65911595185668e-20 NA NA NA hsa-miR-28-5p PTP4A2 -0.14267073663385 0.0497619246260571 0.38574449513147 1.13328117872512e-06 miRanda -0.227965984611241 1.35730245928027e-09 NA NA NA hsa-miR-15a-5p PURA 0.812445324157528 4.50263417099822e-20 -0.438047613118832 4.75770651979866e-13 miRTarBase -0.172946468523848 5.3093612187022e-14 NA NA NA hsa-miR-28-5p PUS7L -0.14267073663385 0.0497619246260571 0.145113950566918 0.0897960737939671 miRanda -0.114959118446961 0.00473506724081946 NA NA NA hsa-miR-28-5p PYCRL -0.14267073663385 0.0497619246260571 1.82468595902489 2.66248549409042e-58 miRanda -0.22504000152473 0.000103907331598124 NA NA NA hsa-miR-375 QKI 2.09893673049766 1.68351780396203e-16 -1.32659632374889 1.06640742607879e-48 miRanda -0.164118705604812 2.46064182729981e-42 NA NA NA hsa-miR-28-5p QSOX1 -0.14267073663385 0.0497619246260571 0.60255748274154 3.62670004110163e-08 miRanda -0.152628390389117 0.00364426402193613 NA NA NA hsa-miR-28-5p RAB11FIP1 -0.14267073663385 0.0497619246260571 0.69116808896398 6.48076941128492e-06 miRanda -0.338905684912959 3.5216293612899e-06 NA NA NA hsa-miR-28-5p RAB14 -0.14267073663385 0.0497619246260571 -0.0753658943653273 0.14399081719528 miRanda -0.104162677236291 1.96703121287158e-05 NA NA NA hsa-miR-28-5p RAB24 -0.14267073663385 0.0497619246260571 0.303475540325776 0.000592601062267745 miRanda -0.161893953740376 0.000118862111928195 NA NA NA hsa-miR-28-5p RAB30 -0.14267073663385 0.0497619246260571 -0.478979836326187 0.00389471393081148 miRanda -0.459147966639985 5.06933876170286e-09 NA NA NA hsa-miR-28-5p RAB31 -0.14267073663385 0.0497619246260571 1.21770647114932 2.0308057149131e-20 miRanda -0.203782492807051 0.00148128168670373 NA NA NA hsa-miR-28-5p RALGAPB -0.14267073663385 0.0497619246260571 0.114339916324857 0.110018355395065 miRanda -0.136336527884099 5.88496299374839e-05 NA NA NA hsa-miR-28-5p RAP1GDS1 -0.14267073663385 0.0497619246260571 0.478268842738917 4.89838888082789e-09 miRanda -0.179884587821433 4.21195745918722e-06 NA NA NA hsa-miR-28-5p RAPGEFL1 -0.14267073663385 0.0497619246260571 0.740048213907199 1.05350561263932e-05 miRanda -0.284270875346076 0.000399239787482548 NA NA NA hsa-miR-375 RASD1 2.09893673049766 1.68351780396203e-16 -1.95553230360219 3.4725544484432e-22 miRTarBase;miRanda -0.130277507987086 1.71447338617167e-06 20978187 A combination of expression profiling from tumor samples and miRNA target prediction identified RASD1 as a potential miR-375 target; Mechanistic investigations revealed that miR-375 regulates RASD1 by targeting the 3' untranslated region in RASD1 mRNA breast cancer hsa-miR-28-5p RASGRP4 -0.14267073663385 0.0497619246260571 -0.655281786974586 6.53684341783125e-09 miRanda -0.1170558792494 0.0311401193861443 NA NA NA hsa-miR-28-5p RBM47 -0.14267073663385 0.0497619246260571 0.732126183413737 2.07916919204205e-13 miRanda -0.336368008731163 1.55575789347527e-12 NA NA NA hsa-miR-28-5p RBM5 -0.14267073663385 0.0497619246260571 -0.402544753547652 4.49201522260434e-13 miRanda -0.117173839370532 1.14468263555622e-05 NA NA NA hsa-miR-590-3p RBM5 1.27438512890514 1.03164723481469e-23 -0.402544753547652 4.49201522260434e-13 miRanda -0.156674546448225 1.64735771750976e-25 NA NA NA hsa-miR-107 RECK 0.678998026350662 2.56224148930538e-16 -1.97765597525965 6.86857718929118e-55 miRanda -0.507388008638714 8.52095123132121e-21 NA NA NA hsa-miR-15b-5p RECK 0.788659356634696 1.13678211092534e-11 -1.97765597525965 6.86857718929118e-55 miRTarBase -0.327498212728994 4.09304517406965e-17 NA NA NA hsa-miR-21-5p RECK 2.32007501846389 3.08394781855554e-137 -1.97765597525965 6.86857718929118e-55 miRTarBase -0.34438163056236 1.21607205369305e-16 19730150;20480266;22642976;18794849;25720799 Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;Furthermore we identified that RECK reversion-inducing-cysteine-rich protein with kazal motifs a tumor suppressor gene was a direct target of miR-21; Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma likely through regulating RECK and may serve as a therapeutic target;miR 21 may acts as an oncomir by targeting RECK a matrix metalloproteinase regulator in prostate cancer; The micro RNA miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase MMP inhibitor RECK; Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line; To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21; To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction qRT-PCR; From men who presented the second profile miR-21 overexpression and RECK underexpression 91.7% were staged pT3; Our results demonstrate RECK as a target of miR-21; We believe that miR-21 may be important in PCa progression through its regulation of RECK a known regulator of tumor cell invasion;Finally we showed that RECK a known tumor suppressor in gastric cancer is a bona fide target of miR-21; Taken together miR-21 may be important in the initiation and progression of gastric cancers as an oncomiR likely through regulating RECK; Our findings suggest a potential regulatory pathway in which H pylori infection upregulates expression of miR-21 which in turn downregulates RECK and then leads to the development of gastric cancer;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression ;;staging;progression;progression;metastasis;progression pancreatic cancer;sarcoma;prostate cancer;gastric cancer;liver cancer hsa-miR-320b RECK 0.412787504747938 0.00113457276903985 -1.97765597525965 6.86857718929118e-55 miRanda -0.159561418448099 1.42443066544968e-05 NA NA NA hsa-miR-338-3p RECK 0.0799903526884966 0.575137668326679 -1.97765597525965 6.86857718929118e-55 miRanda -0.254730364343926 2.32051233049701e-15 NA NA NA hsa-miR-429 RECK 2.84108892259147 3.88520896426515e-64 -1.97765597525965 6.86857718929118e-55 miRanda -0.376886287234823 1.65371973632574e-55 NA NA NA hsa-miR-590-3p RECK 1.27438512890514 1.03164723481469e-23 -1.97765597525965 6.86857718929118e-55 miRanda -0.368217888997253 3.54582989854036e-24 27757042 miR 590 5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway gastric cancer hsa-miR-590-5p RECK 0.746515607868274 8.51300479640125e-09 -1.97765597525965 6.86857718929118e-55 miRanda -0.28700792852222 2.66764353478599e-16 27757042 miR 590 5p regulates gastric cancer cell growth and chemosensitivity through RECK and the AKT/ERK pathway; RECK was identified as a direct target of miR-590-5p; Furthermore reintroduction of RECK inhibited the oncogenic effects of miR-590-5p by suppressing cell proliferation and invasion and increasing drug sensitivity gastric cancer hsa-miR-28-5p REEP1 -0.14267073663385 0.0497619246260571 0.546339756833729 0.0100889448892189 miRanda -0.801186934216671 8.69273047648115e-16 NA NA NA hsa-miR-107 RELN 0.678998026350662 2.56224148930538e-16 -4.67087443281158 1.50848083381937e-55 miRanda -0.883231456020123 7.63489077408637e-12 NA NA NA hsa-miR-128-3p RELN 0.90296715955238 9.925204823863e-23 -4.67087443281158 1.50848083381937e-55 miRTarBase -0.862415996814179 5.48710419496746e-14 NA NA NA hsa-miR-142-3p RELN 1.53951237846104 2.06769936282034e-17 -4.67087443281158 1.50848083381937e-55 miRanda -0.178494228225566 0.00252091909305814 NA NA NA hsa-miR-429 RELN 2.84108892259147 3.88520896426515e-64 -4.67087443281158 1.50848083381937e-55 miRanda -0.68086775368573 1.39890314174555e-31 NA NA NA hsa-miR-590-3p RELN 1.27438512890514 1.03164723481469e-23 -4.67087443281158 1.50848083381937e-55 miRanda -0.639422421570865 1.47439876580058e-13 NA NA NA hsa-miR-21-5p REST 2.32007501846389 3.08394781855554e-137 -0.529102545454462 0.00122391255708562 miRTarBase -0.234347286034385 4.181202706174e-06 NA NA NA hsa-miR-375 RGN 2.09893673049766 1.68351780396203e-16 -3.24136216767839 1.75542402265639e-44 miRanda -0.25133943522917 2.71206119935792e-15 NA NA NA hsa-miR-193a-3p RGS2 0.310617999804917 0.00477640270974957 -2.22301490243853 1.94638141880336e-39 miRanda -0.14922718363043 0.00711834500021436 NA NA NA hsa-miR-342-3p RGS2 1.21944481975657 6.81914373001202e-19 -2.22301490243853 1.94638141880336e-39 miRanda -0.395582492376971 1.1356012057187e-20 NA NA NA hsa-miR-590-3p RGS2 1.27438512890514 1.03164723481469e-23 -2.22301490243853 1.94638141880336e-39 miRanda -0.153960404417252 0.00161112650099528 NA NA NA hsa-miR-375 RHOQ 2.09893673049766 1.68351780396203e-16 -1.35438478184297 3.37585411116795e-60 miRanda -0.125276909188229 3.64884172005162e-28 NA NA NA hsa-miR-28-5p RHOT1 -0.14267073663385 0.0497619246260571 -0.270568764875986 8.26985055768295e-05 miRanda -0.107030886738767 0.00109224356536059 NA NA NA hsa-miR-28-5p RIMS4 -0.14267073663385 0.0497619246260571 1.93936813754878 1.60005847788467e-09 miRanda -1.19551474512527 4.05189387001245e-15 NA NA NA hsa-miR-28-5p RMST -0.14267073663385 0.0497619246260571 -2.44382192551357 5.91433025323596e-08 miRanda -0.449675579460211 0.00994127001403051 NA NA NA hsa-miR-200b-3p RND3 2.11744072703209 1.66710572104191e-43 -1.70606216262212 4.40038671490463e-36 miRTarBase -0.198068196895994 3.25777991523227e-11 26935796 MicroRNA 200b inhibits epithelial mesenchymal transition and migration of cervical cancer cells by directly targeting RhoE cervical and endocervical cancer hsa-miR-28-5p RNF10 -0.14267073663385 0.0497619246260571 0.183922227767296 7.82104616512277e-06 miRanda -0.14080061678934 3.19560723383641e-13 NA NA NA hsa-miR-155-5p RNF123 1.09766314984151 4.55650930885814e-15 0.26937576767789 6.92750150297045e-07 miRTarBase -0.108183396164596 4.37430188064077e-17 NA NA NA hsa-miR-28-5p RNF187 -0.14267073663385 0.0497619246260571 1.01633369097037 2.51780917868843e-52 miRanda -0.142009177223535 2.67776542852784e-05 NA NA NA hsa-miR-28-5p RPLP0P2 -0.14267073663385 0.0497619246260571 2.37092895765011 4.02584451390848e-74 miRanda -0.188975627128783 0.00552319763125875 NA NA NA hsa-miR-375 RPRM 2.09893673049766 1.68351780396203e-16 -0.339849576303362 0.160381920538011 miRanda -0.126176516126823 7.46235837107678e-05 NA NA NA hsa-miR-28-5p RPS6KA5 -0.14267073663385 0.0497619246260571 -0.957245810152851 9.30300768011881e-15 miRanda -0.174299109370714 0.00356769791900598 NA NA NA hsa-miR-28-5p RRM2B -0.14267073663385 0.0497619246260571 0.104156612356596 0.252644515445598 miRanda -0.182015578311515 2.50011313753227e-05 NA NA NA hsa-miR-375 RRN3P2 2.09893673049766 1.68351780396203e-16 -0.257078799540809 0.0170125916082822 miRanda -0.117847042100417 2.96346601745251e-17 NA NA NA hsa-miR-375 RSU1 2.09893673049766 1.68351780396203e-16 -0.387064764730159 4.65594507170923e-06 miRanda -0.151351458433912 1.77092495673847e-46 NA NA NA hsa-miR-21-5p RTN4 2.32007501846389 3.08394781855554e-137 -0.601034406966253 3.97552525003937e-25 miRTarBase -0.190348578635845 5.32438743284111e-26 NA NA NA hsa-miR-28-5p RTN4RL1 -0.14267073663385 0.0497619246260571 0.0235441317845835 0.90079236818366 miRanda -0.876981766929322 1.19675645433379e-23 NA NA NA hsa-miR-28-5p RUNDC1 -0.14267073663385 0.0497619246260571 0.295842513834232 0.000580189934087065 miRanda -0.341668097976478 2.11469014255674e-17 NA NA NA hsa-miR-107 RUNX1T1 0.678998026350662 2.56224148930538e-16 -2.57048990739789 4.6896723401076e-41 miRanda -0.770770966765673 9.72508611452404e-22 NA NA NA hsa-miR-125a-3p RUNX1T1 -0.176412960953959 0.10108079286419 -2.57048990739789 4.6896723401076e-41 miRanda -0.209249785222083 0.00119019030554968 NA NA NA hsa-miR-146b-5p RUNX1T1 0.631041661167954 6.20366593452965e-08 -2.57048990739789 4.6896723401076e-41 miRanda -0.253637843755312 1.60847778770148e-05 NA NA NA hsa-miR-193a-3p RUNX1T1 0.310617999804917 0.00477640270974957 -2.57048990739789 4.6896723401076e-41 miRanda -0.341750931449974 4.55374400131589e-08 NA NA NA hsa-miR-324-5p RUNX1T1 0.211552647440779 0.139408130311654 -2.57048990739789 4.6896723401076e-41 miRanda -0.365567319900127 1.65175164962249e-14 NA NA NA hsa-miR-338-3p RUNX1T1 0.0799903526884966 0.575137668326679 -2.57048990739789 4.6896723401076e-41 miRanda -0.311298780683904 9.13619912538747e-11 NA NA NA hsa-miR-342-3p RUNX1T1 1.21944481975657 6.81914373001202e-19 -2.57048990739789 4.6896723401076e-41 miRanda -0.265516526095294 5.88407586748424e-08 NA NA NA hsa-miR-361-5p RUNX1T1 -0.0996867547900457 0.095428250126326 -2.57048990739789 4.6896723401076e-41 miRanda -0.60735672959624 2.08219439213972e-07 NA NA NA hsa-miR-28-5p RWDD2A -0.14267073663385 0.0497619246260571 0.125683302205475 0.0854271541365872 miRanda -0.126326393967917 0.000271630782118608 NA NA NA hsa-miR-375 RYR2 2.09893673049766 1.68351780396203e-16 -0.895189916284699 1.42900516050702e-05 miRanda -0.122559203532273 6.82386248367019e-06 NA NA NA hsa-miR-590-3p SAA2 1.27438512890514 1.03164723481469e-23 -4.94046297970105 1.4338503576543e-47 miRanda -0.386052324639402 0.000101379361604242 NA NA NA hsa-miR-375 SAMD4A 2.09893673049766 1.68351780396203e-16 -1.7968635515046 2.10294718067867e-53 miRanda -0.170903928596782 9.87858622535318e-27 NA NA NA hsa-miR-28-5p SCAMP4 -0.14267073663385 0.0497619246260571 0.614297407813703 1.11749160548696e-19 miRanda -0.22839424792154 2.22663220756444e-12 NA NA NA hsa-miR-28-5p SCAMP5 -0.14267073663385 0.0497619246260571 0.907126239257327 6.22969102491787e-15 miRanda -0.176739481873598 0.00169322267288296 NA NA NA hsa-miR-140-5p SCGB2A1 -0.755971041589807 9.68060922934542e-14 -0.285150586947695 0.464266297353636 miRanda -0.398305199505209 0.00217646604757875 NA NA NA hsa-miR-140-5p SCGB2A2 -0.755971041589807 9.68060922934542e-14 -1.53507753311163 0.00777502908192117 miRanda -0.788650513063007 4.11448611003728e-05 NA NA NA hsa-miR-142-3p SCGB2A2 1.53951237846104 2.06769936282034e-17 -1.53507753311163 0.00777502908192117 miRanda -0.545310044444354 2.96326121933926e-07 NA NA NA hsa-miR-107 SCN3A 0.678998026350662 2.56224148930538e-16 -4.0564772332002 1.56940161813981e-68 miRanda -0.87450470683762 6.55911682871278e-18 NA NA NA hsa-miR-320b SCN3A 0.412787504747938 0.00113457276903985 -4.0564772332002 1.56940161813981e-68 miRanda -0.429961588805172 2.64248848852711e-10 NA NA NA hsa-miR-429 SCN3A 2.84108892259147 3.88520896426515e-64 -4.0564772332002 1.56940161813981e-68 miRanda -0.600080777813446 1.95653358490526e-39 NA NA NA hsa-miR-590-3p SCN3A 1.27438512890514 1.03164723481469e-23 -4.0564772332002 1.56940161813981e-68 miRanda -0.59126879984344 4.12140545487601e-18 NA NA NA hsa-miR-590-5p SCN3A 0.746515607868274 8.51300479640125e-09 -4.0564772332002 1.56940161813981e-68 miRanda -0.576843881450256 7.62804920182469e-19 NA NA NA hsa-miR-28-5p SCUBE1 -0.14267073663385 0.0497619246260571 -1.08277169869843 7.17388900019697e-05 miRanda -0.353971159496076 0.00665611802321946 NA NA NA hsa-miR-375 SDC2 2.09893673049766 1.68351780396203e-16 -0.778768700466077 1.75535307602845e-09 miRanda -0.135574098406759 1.24555079165715e-15 NA NA NA hsa-miR-28-5p SEC16A -0.14267073663385 0.0497619246260571 0.705401856519326 1.92241123956851e-20 miRanda -0.339102192526052 8.28289847991014e-21 NA NA NA hsa-miR-28-5p SEC23IP -0.14267073663385 0.0497619246260571 0.204057998350036 0.00401511033994364 miRanda -0.135069810091733 6.12254771224588e-05 NA NA NA hsa-miR-28-5p SEMA4B -0.14267073663385 0.0497619246260571 0.85463500471788 2.10181293576613e-16 miRanda -0.209395080388177 3.172581117495e-05 NA NA NA hsa-miR-28-5p SERHL -0.14267073663385 0.0497619246260571 -0.645855068242783 0.00196100425848289 miRanda -0.229659952245983 0.00409157837596331 NA NA NA hsa-miR-28-5p SERHL2 -0.14267073663385 0.0497619246260571 -0.343857304888721 0.211470376872396 miRanda -0.539276926118838 3.69430260584961e-05 NA NA NA hsa-miR-28-5p SERPINA1 -0.14267073663385 0.0497619246260571 0.396626436447673 0.0640799863509273 miRanda -0.203400299005591 0.0465295085588463 NA NA NA hsa-miR-28-5p SERPINA5 -0.14267073663385 0.0497619246260571 -0.519209583936095 0.103183128111987 miRanda -0.774799437153621 2.86498994052742e-07 NA NA NA hsa-miR-28-5p SESN1 -0.14267073663385 0.0497619246260571 -0.952506930201764 9.2781623761265e-26 miRanda -0.176225999962169 7.4172729512754e-05 NA NA NA hsa-miR-28-5p SETD3 -0.14267073663385 0.0497619246260571 -0.269540757095891 6.11415488403297e-09 miRanda -0.120126356803789 5.06213015407305e-08 NA NA NA hsa-miR-28-5p SFI1 -0.14267073663385 0.0497619246260571 0.732803203984513 3.09771867450456e-15 miRanda -0.118946816609226 0.00822629167514562 NA NA NA hsa-miR-28-5p SFXN1 -0.14267073663385 0.0497619246260571 1.00730972646257 1.50510712985854e-31 miRanda -0.247575672122889 4.90943877345944e-09 NA NA NA hsa-miR-28-5p SFXN2 -0.14267073663385 0.0497619246260571 1.08971879328793 7.30694562473144e-18 miRanda -0.338083961196289 3.19538617411812e-08 NA NA NA hsa-miR-28-5p SGSH -0.14267073663385 0.0497619246260571 0.131555704868576 0.0379109975142145 miRanda -0.100760708072422 0.000816389719327486 NA NA NA hsa-miR-28-5p SGSM2 -0.14267073663385 0.0497619246260571 -0.226680479630394 0.0136805050128053 miRanda -0.114807613503313 0.00877829877218787 NA NA NA hsa-miR-28-5p SH3BGRL -0.14267073663385 0.0497619246260571 0.268820390705558 0.0442547470608479 miRanda -0.203847085630723 0.00135374949702198 NA NA NA hsa-miR-375 SH3GL3 2.09893673049766 1.68351780396203e-16 -0.777875637175819 0.00225496391436024 miRanda -0.235975723124802 1.25850187508117e-12 NA NA NA hsa-miR-375 SHANK3 2.09893673049766 1.68351780396203e-16 -1.33183457706851 3.20517661766363e-41 miRanda -0.124834500619257 1.5030788773527e-20 NA NA NA hsa-miR-28-5p SHISA2 -0.14267073663385 0.0497619246260571 -0.0881092399519519 0.754073621031887 miRanda -0.396778641338464 0.00303480221724045 NA NA NA hsa-miR-28-5p SHISA6 -0.14267073663385 0.0497619246260571 -1.68226082206879 2.45685318014832e-13 miRanda -0.234893998087409 0.0346973294930808 NA NA NA hsa-miR-375 SHOX2 2.09893673049766 1.68351780396203e-16 -0.717729047322027 6.5727195471221e-09 miRanda -0.14931751902148 1.66303863155422e-20 24746361 SHOX2 is a direct miR 375 target and a novel epithelial to mesenchymal transition inducer in breast cancer cells breast cancer hsa-miR-28-5p SIPA1L3 -0.14267073663385 0.0497619246260571 1.14456261546297 2.77744871058553e-40 miRanda -0.169840461616851 7.87079640561921e-05 NA NA NA hsa-miR-28-5p SIRT3 -0.14267073663385 0.0497619246260571 0.0107489864050141 0.879499666544636 miRanda -0.26212648335716 2.62798701565363e-15 NA NA NA hsa-miR-375 SLAIN1 2.09893673049766 1.68351780396203e-16 -2.0290956913259 2.56704037099149e-19 miRanda -0.156226540934221 2.53900044786838e-07 NA NA NA hsa-miR-28-5p SLC1A7 -0.14267073663385 0.0497619246260571 -1.89898960979584 3.58937473841316e-24 miRanda -0.203026000903691 0.0271945182255877 NA NA NA hsa-miR-28-5p SLC24A1 -0.14267073663385 0.0497619246260571 -0.404947269243294 2.78114264738042e-07 miRanda -0.204201346532967 5.23054938284372e-08 NA NA NA hsa-miR-28-5p SLC25A38 -0.14267073663385 0.0497619246260571 0.217477580021136 0.000198540649760527 miRanda -0.206918858185028 4.85128860783084e-14 NA NA NA hsa-miR-28-5p SLC25A45 -0.14267073663385 0.0497619246260571 0.176528287332551 0.0319167814740833 miRanda -0.210753344836521 6.12562039555599e-08 NA NA NA hsa-miR-320b SLC26A3 0.412787504747938 0.00113457276903985 -2.81725286544275 7.31729718395371e-13 miRanda -0.77881944699446 3.03538778767069e-13 NA NA NA hsa-miR-330-5p SLC26A3 0.626063225953928 3.42215028606779e-09 -2.81725286544275 7.31729718395371e-13 miRanda -0.935148692750203 1.40903373309383e-13 NA NA NA hsa-miR-429 SLC26A3 2.84108892259147 3.88520896426515e-64 -2.81725286544275 7.31729718395371e-13 miRanda -0.420666006270455 2.00094659041392e-08 NA NA NA hsa-miR-590-3p SLC26A3 1.27438512890514 1.03164723481469e-23 -2.81725286544275 7.31729718395371e-13 miRanda -1.09174022588467 1.10807222847701e-24 NA NA NA hsa-miR-375 SLC2A12 2.09893673049766 1.68351780396203e-16 -1.40463552306912 2.97069732350071e-24 miRanda -0.154861735545829 4.36420514041692e-17 NA NA NA hsa-miR-28-5p SLC44A5 -0.14267073663385 0.0497619246260571 -0.219753996293499 0.440105379643692 miRanda -0.605333732419013 7.37553109686195e-06 NA NA NA hsa-miR-28-5p SLC6A4 -0.14267073663385 0.0497619246260571 0.832715997717498 0.0306047620635539 miRanda -0.671833824606927 0.000247165301550305 NA NA NA hsa-miR-125a-3p SLIT3 -0.176412960953959 0.10108079286419 -2.26432098697292 2.92136586837965e-51 miRanda -0.117430045928778 0.0223794021584394 NA NA NA hsa-miR-330-5p SLIT3 0.626063225953928 3.42215028606779e-09 -2.26432098697292 2.92136586837965e-51 miRanda -0.373850486103042 2.05859090886874e-13 NA NA NA hsa-miR-590-3p SLIT3 1.27438512890514 1.03164723481469e-23 -2.26432098697292 2.92136586837965e-51 miRanda -0.528597525756374 5.46215889593109e-36 NA NA NA hsa-miR-590-5p SLIT3 0.746515607868274 8.51300479640125e-09 -2.26432098697292 2.92136586837965e-51 miRanda -0.477978043456429 4.36387222890957e-32 NA NA NA hsa-miR-155-5p SMAD5 1.09766314984151 4.55650930885814e-15 -0.545010310954351 1.14150258900381e-14 miRTarBase -0.165640259153535 6.62054395693184e-23 20133617 Targeting of SMAD5 links microRNA 155 to the TGF beta pathway and lymphomagenesis; Using unbiased genome-wide approaches in DLBCL we discovered that the oncogenic microRNA-155 miR-155 directly targets the bone morphogenetic protein BMP-responsive transcriptional factor SMAD5; In confirmatory experiments RNAi-based SMAD5 knockdown recapitulated in vitro and in vivo the effects miR-155 overexpression; Furthermore in primary DLBCLs miR-155 overexpression inhibited SMAD5 expression and disrupted its activity as defined by individual and global analyses of its transcriptional targets; Together our data helped explain miR-155 function highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects lymphoma hsa-miR-28-5p SMARCC2 -0.14267073663385 0.0497619246260571 -0.227365550061606 4.75275814043985e-07 miRanda -0.140280402202475 4.7343458860196e-11 NA NA NA hsa-miR-28-5p SMUG1 -0.14267073663385 0.0497619246260571 0.606414386600416 3.40733965995423e-19 miRanda -0.224300530222957 5.5767010594015e-12 NA NA NA hsa-miR-375 SMYD1 2.09893673049766 1.68351780396203e-16 -5.59423095315222 4.87566775628026e-53 miRanda -0.339711636402984 2.54805404463676e-11 NA NA NA hsa-miR-375 SNAI2 2.09893673049766 1.68351780396203e-16 -0.929098872578741 6.81961748391463e-14 miRanda -0.147761834840226 9.62714562907298e-20 NA NA NA hsa-miR-28-5p SNAP23 -0.14267073663385 0.0497619246260571 -0.00190318843343817 0.971884090942836 miRanda -0.133008859520424 1.76795790321163e-07 NA NA NA hsa-miR-375 SNAP91 2.09893673049766 1.68351780396203e-16 -0.916150785435058 0.000141100985259601 miRanda -0.170345638080221 7.45496425624345e-08 NA NA NA hsa-miR-28-5p SNRPN -0.14267073663385 0.0497619246260571 -0.145756373517547 0.194678771019692 miRanda -0.264927747076875 6.445156224726e-07 NA NA NA hsa-miR-28-5p SNX13 -0.14267073663385 0.0497619246260571 -0.47494994622097 8.24215014257509e-11 miRanda -0.114077424788396 0.00117219357673941 NA NA NA hsa-miR-28-5p SNX19 -0.14267073663385 0.0497619246260571 -0.332901048450884 1.43819698027206e-07 miRanda -0.111921626247476 0.00021533004209152 NA NA NA hsa-miR-107 SOCS2 0.678998026350662 2.56224148930538e-16 -1.85803882323019 1.27461377734762e-27 miRanda -0.357619634378991 6.32055929228e-07 NA NA NA hsa-miR-194-5p SOCS2 0.467781870340114 1.0386810618625e-07 -1.85803882323019 1.27461377734762e-27 miRTarBase -0.267533169196439 9.55649717737723e-05 22102710 Functional studies indicated that CDKN1A/p21 and SOCS2 expression is directly regulated by miR-20a/-20b and miR-194 respectively; miR-20a/b and miR-194 target CDKN1A and SOCS2 in follicular lymphoma potentially contributing to tumor cell proliferation and survival poor survival lymphoma hsa-miR-320b SOCS2 0.412787504747938 0.00113457276903985 -1.85803882323019 1.27461377734762e-27 miRanda -0.338842656804501 8.00699810186314e-13 NA NA NA hsa-miR-324-5p SOCS2 0.211552647440779 0.139408130311654 -1.85803882323019 1.27461377734762e-27 miRanda -0.388085632924069 5.89601551540041e-21 NA NA NA hsa-miR-342-3p SOCS2 1.21944481975657 6.81914373001202e-19 -1.85803882323019 1.27461377734762e-27 miRanda -0.131773960458645 0.00223324523415912 NA NA NA hsa-miR-21-5p SOD3 2.32007501846389 3.08394781855554e-137 -2.658433816252 9.8267493618625e-47 miRTarBase -0.541158204506034 1.67623518096689e-19 NA NA NA hsa-miR-146b-5p SORBS1 0.631041661167954 6.20366593452965e-08 -3.50225138578409 2.05072701787994e-102 miRanda -0.341899086558465 1.98854423701487e-10 NA NA NA hsa-miR-542-3p SORBS1 0.568822103820889 8.5699075257651e-07 -3.50225138578409 2.05072701787994e-102 miRanda -0.185757778100877 0.000693513369206205 NA NA NA hsa-miR-590-3p SORBS1 1.27438512890514 1.03164723481469e-23 -3.50225138578409 2.05072701787994e-102 miRanda -0.533042984363902 3.7060229493105e-27 NA NA NA hsa-miR-590-5p SORBS1 0.746515607868274 8.51300479640125e-09 -3.50225138578409 2.05072701787994e-102 miRanda -0.376087906334386 4.42467931934288e-15 NA NA NA hsa-miR-28-5p SORCS1 -0.14267073663385 0.0497619246260571 -1.17464209650385 0.00185228663810649 miRanda -0.461554834766473 0.010437753492585 NA NA NA hsa-miR-590-3p SOSTDC1 1.27438512890514 1.03164723481469e-23 -3.68382305978272 4.08185002450465e-28 miRanda -0.227989683559222 0.0168578301928653 NA NA NA hsa-miR-330-5p SOX10 0.626063225953928 3.42215028606779e-09 -4.31034919377284 2.18221209133001e-21 miRanda -0.334294407887576 0.0258225487908952 NA NA NA hsa-miR-590-3p SOX10 1.27438512890514 1.03164723481469e-23 -4.31034919377284 2.18221209133001e-21 miRanda -0.266558563095154 0.0375254041635988 NA NA NA hsa-miR-21-5p SOX5 2.32007501846389 3.08394781855554e-137 -2.72079957365634 5.8401556767149e-39 miRTarBase -0.756030812927406 1.40346547972103e-30 NA NA NA hsa-miR-21-5p SP1 2.32007501846389 3.08394781855554e-137 -0.354351925158745 1.46585727332836e-11 miRTarBase -0.155768447861795 3.88544448292272e-22 NA NA NA hsa-miR-28-5p SPAG1 -0.14267073663385 0.0497619246260571 1.21536502852341 1.21867718052225e-27 miRanda -0.283385630238123 2.1349786014205e-07 NA NA NA hsa-miR-28-5p SPARC -0.14267073663385 0.0497619246260571 0.260111874990256 0.034213916848521 miRanda -0.128260261137617 0.0285436818829644 NA NA NA hsa-miR-28-5p SPATA2 -0.14267073663385 0.0497619246260571 0.422408617204912 3.11792520748896e-12 miRanda -0.131824028628949 5.76197976366993e-06 NA NA NA hsa-miR-28-5p SPATA20 -0.14267073663385 0.0497619246260571 0.44118485989573 8.656953078129e-05 miRanda -0.500777774110776 1.23992642174534e-21 NA NA NA hsa-miR-28-5p SPATA5L1 -0.14267073663385 0.0497619246260571 0.178145637609615 0.00049083620708605 miRanda -0.102077664728975 2.56348708697251e-05 NA NA NA hsa-miR-28-5p SPEF2 -0.14267073663385 0.0497619246260571 0.0180087182537036 0.892221023811872 miRanda -0.441848875618062 1.50726561843833e-12 NA NA NA hsa-miR-28-5p SPNS1 -0.14267073663385 0.0497619246260571 0.863726955106674 4.25847180628551e-32 miRanda -0.133019080595056 0.000236964129139015 NA NA NA hsa-miR-375 SPOCK3 2.09893673049766 1.68351780396203e-16 -2.9791873535921 4.19634385238139e-30 miRanda -0.15981451400541 7.35569684192794e-06 NA NA NA hsa-miR-21-5p SPRY2 2.32007501846389 3.08394781855554e-137 -2.72906279183225 4.36360171627142e-90 miRTarBase -0.684722889689909 7.12948810098069e-54 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-330-5p SPRY2 0.626063225953928 3.42215028606779e-09 -2.72906279183225 4.36360171627142e-90 miRanda -0.331174994713037 7.23637017911274e-12 NA NA NA hsa-miR-429 SPRY2 2.84108892259147 3.88520896426515e-64 -2.72906279183225 4.36360171627142e-90 miRanda -0.370395879934324 8.88044596656627e-42 NA NA NA hsa-miR-590-3p SPRY2 1.27438512890514 1.03164723481469e-23 -2.72906279183225 4.36360171627142e-90 miRanda -0.343285307851214 5.68372674302789e-17 NA NA NA hsa-miR-590-5p SPRY2 0.746515607868274 8.51300479640125e-09 -2.72906279183225 4.36360171627142e-90 miRanda -0.195337240970435 8.73594803853544e-07 NA NA NA hsa-miR-146b-5p SPTBN1 0.631041661167954 6.20366593452965e-08 -1.9362598712969 2.27075223607576e-99 miRanda -0.19734477986187 4.85511021700294e-11 NA NA NA hsa-miR-342-3p SPTBN1 1.21944481975657 6.81914373001202e-19 -1.9362598712969 2.27075223607576e-99 miRanda -0.199230264137633 1.30085114740997e-15 NA NA NA hsa-miR-429 SPTBN1 2.84108892259147 3.88520896426515e-64 -1.9362598712969 2.27075223607576e-99 miRanda -0.255244390904648 1.12964494747244e-42 NA NA NA hsa-miR-542-3p SPTBN1 0.568822103820889 8.5699075257651e-07 -1.9362598712969 2.27075223607576e-99 miRanda -0.185189984370535 1.08666084316449e-09 NA NA NA hsa-miR-590-3p SPTBN1 1.27438512890514 1.03164723481469e-23 -1.9362598712969 2.27075223607576e-99 miRanda -0.167108510270875 3.39317189829615e-09 NA NA NA hsa-miR-28-5p SQSTM1 -0.14267073663385 0.0497619246260571 0.337430896843218 6.84019405897406e-06 miRanda -0.184705196991679 2.22156890650776e-07 NA NA NA hsa-miR-28-5p SRCIN1 -0.14267073663385 0.0497619246260571 1.01769401933761 6.04876320869876e-10 miRanda -0.442078106154846 1.85478243537203e-08 NA NA NA hsa-miR-107 SRPX 0.678998026350662 2.56224148930538e-16 -2.76754006067394 2.62007748776865e-67 miRanda -0.534182821307586 2.42302077600689e-14 NA NA NA hsa-miR-320b SRPX 0.412787504747938 0.00113457276903985 -2.76754006067394 2.62007748776865e-67 miRanda -0.187475393405449 6.90393347419906e-05 NA NA NA hsa-miR-338-3p SRPX 0.0799903526884966 0.575137668326679 -2.76754006067394 2.62007748776865e-67 miRanda -0.234062765208853 1.75075810300805e-08 NA NA NA hsa-miR-28-5p SSBP2 -0.14267073663385 0.0497619246260571 -0.688186904830189 6.78722403001534e-13 miRanda -0.298326289348499 7.2427398305492e-11 NA NA NA hsa-miR-28-5p STC1 -0.14267073663385 0.0497619246260571 0.0174437759200483 0.927534883709258 miRanda -0.420438503201195 3.76779887199724e-06 NA NA NA hsa-miR-28-5p STK16 -0.14267073663385 0.0497619246260571 0.402504151002991 9.90775556523305e-12 miRanda -0.188797357633773 1.9631444476179e-11 NA NA NA hsa-miR-28-5p STK36 -0.14267073663385 0.0497619246260571 0.377236149506294 6.85193611730421e-06 miRanda -0.22144955704607 2.71205283096417e-08 NA NA NA hsa-miR-28-5p STOM -0.14267073663385 0.0497619246260571 -0.649999293476048 7.55025346293203e-11 miRanda -0.145691676720967 0.00243906835735245 NA NA NA hsa-miR-375 STON1 2.09893673049766 1.68351780396203e-16 -1.5979483127904 5.46305194597446e-37 miRanda -0.190618004671118 5.64382290590757e-30 NA NA NA hsa-miR-28-5p STRADB -0.14267073663385 0.0497619246260571 -0.643341720695693 4.11123485334864e-15 miRanda -0.154073446657361 9.90677268422725e-05 NA NA NA hsa-miR-375 STX11 2.09893673049766 1.68351780396203e-16 -1.90080834713827 1.4956408342951e-50 miRanda -0.193274839875399 4.26229203092568e-29 NA NA NA hsa-miR-107 SVEP1 0.678998026350662 2.56224148930538e-16 -3.50443766246167 5.19163462333551e-73 miRanda -0.779414628467289 5.02453489495002e-20 NA NA NA hsa-miR-193a-3p SVEP1 0.310617999804917 0.00477640270974957 -3.50443766246167 5.19163462333551e-73 miRanda -0.3454703597145 1.63513739939664e-07 NA NA NA hsa-miR-320b SVEP1 0.412787504747938 0.00113457276903985 -3.50443766246167 5.19163462333551e-73 miRanda -0.411905545890819 5.06602859255392e-13 NA NA NA hsa-miR-330-5p SVEP1 0.626063225953928 3.42215028606779e-09 -3.50443766246167 5.19163462333551e-73 miRanda -0.476956576410378 1.7132579098969e-12 NA NA NA hsa-miR-338-3p SVEP1 0.0799903526884966 0.575137668326679 -3.50443766246167 5.19163462333551e-73 miRanda -0.218734228335693 1.80860224569352e-05 NA NA NA hsa-miR-339-5p SVEP1 -0.211548290465418 0.0685885445822389 -3.50443766246167 5.19163462333551e-73 miRanda -0.227895063691445 0.000286525747350998 NA NA NA hsa-miR-342-3p SVEP1 1.21944481975657 6.81914373001202e-19 -3.50443766246167 5.19163462333551e-73 miRanda -0.31960200038896 5.48543099514645e-10 NA NA NA hsa-miR-429 SVEP1 2.84108892259147 3.88520896426515e-64 -3.50443766246167 5.19163462333551e-73 miRanda -0.611225859237053 4.65352280676688e-60 NA NA NA hsa-miR-590-3p SVEP1 1.27438512890514 1.03164723481469e-23 -3.50443766246167 5.19163462333551e-73 miRanda -0.72331011891486 2.00384058757016e-38 NA NA NA hsa-miR-590-5p SVEP1 0.746515607868274 8.51300479640125e-09 -3.50443766246167 5.19163462333551e-73 miRanda -0.630910797691777 9.13078413610821e-32 NA NA NA hsa-miR-28-5p SYBU -0.14267073663385 0.0497619246260571 -0.572312328428279 0.00218363989087214 miRanda -0.730310895089721 7.30811267796815e-17 NA NA NA hsa-miR-28-5p SYCE2 -0.14267073663385 0.0497619246260571 1.83143884411464 1.42387265552736e-34 miRanda -0.236968196033737 0.00140462299853398 NA NA NA hsa-miR-28-5p SYNC -0.14267073663385 0.0497619246260571 -0.153981352248731 0.325479128978546 miRanda -0.265851291789184 0.000355254741684812 NA NA NA hsa-miR-193a-3p SYNM 0.310617999804917 0.00477640270974957 -4.06797156584945 1.15604058141547e-76 miRanda -0.340618722123306 5.89514466156867e-06 NA NA NA hsa-miR-324-5p SYNM 0.211552647440779 0.139408130311654 -4.06797156584945 1.15604058141547e-76 miRanda -0.117733563142072 0.0426171009581737 NA NA NA hsa-miR-429 SYNM 2.84108892259147 3.88520896426515e-64 -4.06797156584945 1.15604058141547e-76 miRanda -0.427877610486626 1.08961756323251e-21 NA NA NA hsa-miR-28-5p SYT13 -0.14267073663385 0.0497619246260571 2.91774638341289 1.4380254498439e-12 miRanda -0.705964334486968 0.000384111843790838 NA NA NA hsa-miR-28-5p SYTL4 -0.14267073663385 0.0497619246260571 -0.26631400934631 0.0393829139575531 miRanda -0.456650470025982 5.39086292604251e-14 NA NA NA hsa-miR-375 TACC1 2.09893673049766 1.68351780396203e-16 -2.06208371139115 7.60562503452835e-59 miRanda -0.137180959256047 1.47198134391006e-14 NA NA NA hsa-miR-28-5p TANC2 -0.14267073663385 0.0497619246260571 0.645784897636979 5.11106873490809e-07 miRanda -0.241961164649315 8.34629992228275e-05 NA NA NA hsa-miR-28-5p TAOK2 -0.14267073663385 0.0497619246260571 0.433430948462074 3.95755269074194e-12 miRanda -0.25995291139941 1.14651902610124e-18 NA NA NA hsa-miR-28-5p TARS2 -0.14267073663385 0.0497619246260571 1.02415963397561 8.39575134988038e-47 miRanda -0.122295473108918 0.000663078548652261 NA NA NA hsa-miR-28-5p TAT -0.14267073663385 0.0497619246260571 -4.1700211703831 1.44104525158907e-18 miRanda -0.477313247620828 0.038945109081538 NA NA NA hsa-miR-324-5p TAT 0.211552647440779 0.139408130311654 -4.1700211703831 1.44104525158907e-18 miRanda -0.781675617498854 1.0312288821468e-11 NA NA NA hsa-miR-339-5p TAT -0.211548290465418 0.0685885445822389 -4.1700211703831 1.44104525158907e-18 miRanda -0.466887825546032 0.00112128815053213 NA NA NA hsa-miR-361-5p TAT -0.0996867547900457 0.095428250126326 -4.1700211703831 1.44104525158907e-18 miRanda -0.939375169464243 0.000884424242554144 NA NA NA hsa-miR-429 TAT 2.84108892259147 3.88520896426515e-64 -4.1700211703831 1.44104525158907e-18 miRanda -0.311204622949121 0.000692270824935237 NA NA NA hsa-miR-590-3p TAT 1.27438512890514 1.03164723481469e-23 -4.1700211703831 1.44104525158907e-18 miRanda -0.989108631849608 5.03134216073259e-14 NA NA NA hsa-miR-590-5p TAT 0.746515607868274 8.51300479640125e-09 -4.1700211703831 1.44104525158907e-18 miRanda -0.916071011801059 3.07085548466784e-13 NA NA NA hsa-miR-615-3p TAT 0.659240580933614 0.000360214386152507 -4.1700211703831 1.44104525158907e-18 miRanda -0.579646998452461 6.79068755746026e-11 NA NA NA hsa-miR-28-5p TBX2 -0.14267073663385 0.0497619246260571 0.129922787207087 0.243301824733681 miRanda -0.140703521954603 0.00794171052002852 NA NA NA hsa-miR-28-5p TC2N -0.14267073663385 0.0497619246260571 0.0475147882231264 0.727197958425978 miRanda -0.184267973480312 0.00446523882844074 NA NA NA hsa-miR-107 TCF7L2 0.678998026350662 2.56224148930538e-16 -1.35100342592875 2.87469707303853e-37 miRanda -0.247661729975441 3.82905437520373e-08 NA NA NA hsa-miR-193a-3p TCF7L2 0.310617999804917 0.00477640270974957 -1.35100342592875 2.87469707303853e-37 miRanda -0.13669345972878 7.45997149176231e-05 NA NA NA hsa-miR-338-3p TCF7L2 0.0799903526884966 0.575137668326679 -1.35100342592875 2.87469707303853e-37 miRanda -0.164700048645429 4.65832433017924e-10 NA NA NA hsa-miR-342-3p TCF7L2 1.21944481975657 6.81914373001202e-19 -1.35100342592875 2.87469707303853e-37 miRanda -0.233358442684096 1.49785192802606e-18 NA NA NA hsa-miR-590-3p TCF7L2 1.27438512890514 1.03164723481469e-23 -1.35100342592875 2.87469707303853e-37 miRanda -0.121584977112315 6.35614091956812e-05 NA NA NA hsa-miR-28-5p TCTA -0.14267073663385 0.0497619246260571 0.20213938843336 0.00613628359574618 miRanda -0.198402744330933 1.27950291789586e-08 NA NA NA hsa-miR-28-5p TEX14 -0.14267073663385 0.0497619246260571 0.931242979008404 9.10679550289147e-05 miRanda -0.36038453972202 0.00152927774957985 NA NA NA hsa-miR-28-5p TEX9 -0.14267073663385 0.0497619246260571 0.0509689822456678 0.700082142899211 miRanda -0.1670711645078 0.00798015597379457 NA NA NA hsa-miR-107 TF 0.678998026350662 2.56224148930538e-16 -4.45842792468487 7.01043250085875e-45 miRanda -0.390268229831763 0.00445726595741356 NA NA NA hsa-miR-375 TF 2.09893673049766 1.68351780396203e-16 -4.45842792468487 7.01043250085875e-45 miRanda -0.446184309819529 3.13958326432815e-25 NA NA NA hsa-miR-590-3p TF 1.27438512890514 1.03164723481469e-23 -4.45842792468487 7.01043250085875e-45 miRanda -0.391801409134714 2.04305534827485e-05 NA NA NA hsa-miR-106a-5p TGFBR2 0.574594373206545 0.000145868284001732 -2.39529308737339 4.9899056025782e-85 miRTarBase -0.167004125374202 5.11178559030175e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-107 TGFBR2 0.678998026350662 2.56224148930538e-16 -2.39529308737339 4.9899056025782e-85 miRanda -0.530917906321599 1.66581882091816e-22 NA NA NA hsa-miR-17-5p TGFBR2 0.599531757298529 1.07318660415906e-05 -2.39529308737339 4.9899056025782e-85 miRTarBase -0.344837157501155 3.26279419912174e-25 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-20a-5p TGFBR2 0.44979911120222 0.000602386964327228 -2.39529308737339 4.9899056025782e-85 miRTarBase -0.346418250547717 1.79003902635661e-23 NA NA NA hsa-miR-21-5p TGFBR2 2.32007501846389 3.08394781855554e-137 -2.39529308737339 4.9899056025782e-85 miRTarBase -0.537594809270263 3.47307989185754e-40 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-320b TGFBR2 0.412787504747938 0.00113457276903985 -2.39529308737339 4.9899056025782e-85 miRanda -0.208017816637935 1.58734456312155e-08 NA NA NA hsa-miR-590-3p TGFBR2 1.27438512890514 1.03164723481469e-23 -2.39529308737339 4.9899056025782e-85 miRanda -0.338025545666787 3.04278770804611e-20 NA NA NA hsa-miR-590-5p TGFBR2 0.746515607868274 8.51300479640125e-09 -2.39529308737339 4.9899056025782e-85 miRTarBase;miRanda -0.286652524899627 4.12566791851325e-16 NA NA NA hsa-miR-107 TGFBR3 0.678998026350662 2.56224148930538e-16 -3.32389218515653 1.82193869897655e-62 miRanda -0.734117556175882 2.20770569279332e-17 NA NA NA hsa-miR-193a-3p TGFBR3 0.310617999804917 0.00477640270974957 -3.32389218515653 1.82193869897655e-62 miRanda -0.374767586437559 2.03287587677141e-08 NA NA NA hsa-miR-429 TGFBR3 2.84108892259147 3.88520896426515e-64 -3.32389218515653 1.82193869897655e-62 miRanda -0.442656446217992 3.4698799235337e-29 NA NA NA hsa-miR-590-3p TGFBR3 1.27438512890514 1.03164723481469e-23 -3.32389218515653 1.82193869897655e-62 miRanda -0.499383945875221 8.78045761639286e-18 NA NA NA hsa-miR-590-5p TGFBR3 0.746515607868274 8.51300479640125e-09 -3.32389218515653 1.82193869897655e-62 miRanda -0.428706295757895 1.56025636054314e-14 NA NA NA hsa-miR-375 THEMIS 2.09893673049766 1.68351780396203e-16 -0.694831838764676 0.000974328878154886 miRanda -0.10340398887163 0.000200544360169319 NA NA NA hsa-miR-28-5p THRB -0.14267073663385 0.0497619246260571 -1.90956725674414 3.33207199356048e-40 miRanda -0.27319149495517 0.000145463303643686 NA NA NA hsa-miR-375 TIFAB 2.09893673049766 1.68351780396203e-16 1.31202661231825 2.66225584391736e-08 miRanda -0.160880984653909 2.52018252269725e-07 NA NA NA hsa-miR-28-5p TIMM17B -0.14267073663385 0.0497619246260571 1.26177930091032 3.653096676374e-45 miRanda -0.130289288298862 0.00383630002885173 NA NA NA hsa-miR-21-5p TIMP3 2.32007501846389 3.08394781855554e-137 -1.20767978742507 3.47571209381163e-18 miRTarBase -0.194696613681374 9.95965481820086e-06 23936642;20346171;21820586;25720799;25587717 Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;tumorigenesis;tumorigenesis;poor survival;metastasis;progression; breast cancer;breast cancer;kidney renal cell cancer;liver cancer;melanoma hsa-miR-146b-5p TIMP4 0.631041661167954 6.20366593452965e-08 -5.03206696425627 4.48203574496385e-61 miRanda -0.402280565005135 2.88943919997163e-05 NA NA NA hsa-miR-375 TLE4 2.09893673049766 1.68351780396203e-16 -1.51465899922261 3.23215726524777e-37 miRanda -0.18727485562099 1.84260587974749e-32 NA NA NA hsa-miR-28-5p TM9SF1 -0.14267073663385 0.0497619246260571 0.511606899292477 9.1955728473893e-18 miRanda -0.215783534058051 3.66881145727977e-14 NA NA NA hsa-miR-28-5p TMCO1 -0.14267073663385 0.0497619246260571 0.851360857509368 3.5933761176123e-38 miRanda -0.113140925721111 0.000567460927779503 NA NA NA hsa-miR-28-5p TMED3 -0.14267073663385 0.0497619246260571 1.5516937076501 5.27191563318331e-68 miRanda -0.161128244421002 0.000478744777849298 NA NA NA hsa-miR-375 TMEFF1 2.09893673049766 1.68351780396203e-16 0.19005141193122 0.108846594958955 miRanda -0.109044320303904 1.6023341187386e-12 NA NA NA hsa-miR-28-5p TMEM143 -0.14267073663385 0.0497619246260571 -0.466637204908091 3.9291975727201e-11 miRanda -0.213576348163273 2.24806769006338e-10 NA NA NA hsa-miR-28-5p TMEM144 -0.14267073663385 0.0497619246260571 -0.222974365100777 0.0453860472712897 miRanda -0.391648808451717 7.14375923521578e-14 NA NA NA hsa-miR-28-5p TMEM167A -0.14267073663385 0.0497619246260571 0.0809111072909596 0.146434441090959 miRanda -0.111664828448186 2.29709460466846e-05 NA NA NA hsa-miR-28-5p TMEM215 -0.14267073663385 0.0497619246260571 2.65768345418265 2.3521799065528e-20 miRanda -0.555439357324754 7.2589393236591e-05 NA NA NA hsa-miR-28-5p TMEM229B -0.14267073663385 0.0497619246260571 0.727265089473085 3.07635214377309e-08 miRanda -0.429646253572464 5.46749176294498e-12 NA NA NA hsa-miR-28-5p TMEM9 -0.14267073663385 0.0497619246260571 1.17225854097205 9.42118512805465e-50 miRanda -0.122673788326945 0.00217777126125373 NA NA NA hsa-miR-28-5p TMPRSS4 -0.14267073663385 0.0497619246260571 3.35879061803581 9.9015112131537e-20 miRanda -0.503325088395346 0.00522533815614918 NA NA NA hsa-miR-28-5p TMUB1 -0.14267073663385 0.0497619246260571 1.12105172023654 7.11663811953612e-29 miRanda -0.152750765888196 0.00205613729174163 NA NA NA hsa-miR-320b TNFRSF17 0.412787504747938 0.00113457276903985 -1.13973197708672 5.57311285764964e-05 miRanda -0.182946810878824 0.0177637344074567 NA NA NA hsa-miR-375 TNIP3 2.09893673049766 1.68351780396203e-16 1.17140652530055 6.72791405262974e-07 miRanda -0.182148083397167 4.48000217714373e-09 NA NA NA hsa-miR-28-5p TNK1 -0.14267073663385 0.0497619246260571 0.739466980555803 1.02517411574197e-12 miRanda -0.320837899015955 9.84933977086471e-11 NA NA NA hsa-miR-28-5p TOM1L1 -0.14267073663385 0.0497619246260571 0.704932194727521 7.70954564884351e-09 miRanda -0.356251331334049 8.93759550117042e-10 NA NA NA hsa-miR-28-5p TOX3 -0.14267073663385 0.0497619246260571 1.00432770054387 0.00104894619135282 miRanda -0.896029443840828 6.53496646773437e-10 NA NA NA hsa-miR-16-5p TPPP3 0.46835991343556 1.91125356547776e-06 -1.22116678803612 4.67944287836968e-14 miRTarBase -0.312856425770305 3.84219288610327e-08 NA NA NA hsa-miR-330-5p TPPP3 0.626063225953928 3.42215028606779e-09 -1.22116678803612 4.67944287836968e-14 miRanda -0.242686679321002 4.16436053985636e-06 NA NA NA hsa-miR-375 TPTE2P1 2.09893673049766 1.68351780396203e-16 -1.65341936749609 2.47777472989518e-23 miRanda -0.118231768261213 1.3137217747722e-07 NA NA NA hsa-miR-28-5p TRIM23 -0.14267073663385 0.0497619246260571 -0.683201005926275 2.66644008303317e-19 miRanda -0.24115237133317 4.6089734472748e-11 NA NA NA hsa-miR-28-5p TRPS1 -0.14267073663385 0.0497619246260571 0.975779250773293 1.00018911688075e-11 miRanda -0.141435859063669 0.0410592316645809 NA NA NA hsa-miR-28-5p TRUB2 -0.14267073663385 0.0497619246260571 0.674503131886807 1.91964910840085e-28 miRanda -0.167148321435792 2.03074836591556e-08 NA NA NA hsa-miR-28-5p TSG101 -0.14267073663385 0.0497619246260571 0.296712396871171 9.16329380962956e-09 miRanda -0.151996263076067 5.58777477793531e-10 NA NA NA hsa-miR-155-5p TSHZ3 1.09766314984151 4.55650930885814e-15 -0.73282959487018 6.60562399903423e-11 miRTarBase -0.128510042937585 2.35131927026729e-06 NA NA NA hsa-miR-28-5p TSNAX -0.14267073663385 0.0497619246260571 0.422819928987759 7.41936878269938e-12 miRanda -0.124763553794833 2.54924890571281e-05 NA NA NA hsa-miR-28-5p TTC25 -0.14267073663385 0.0497619246260571 0.0268474985965776 0.854483881724695 miRanda -0.246590592818799 0.000393070449956777 NA NA NA hsa-miR-28-5p TTC39A -0.14267073663385 0.0497619246260571 1.75127730029576 1.95458566556964e-23 miRanda -0.561215658602864 4.32187154676238e-11 NA NA NA hsa-miR-28-5p TTC39C -0.14267073663385 0.0497619246260571 0.148888218233073 0.119005357502186 miRanda -0.238856584253465 1.2467565465088e-07 NA NA NA hsa-miR-28-5p TTC8 -0.14267073663385 0.0497619246260571 0.178398576559903 0.035079271986482 miRanda -0.380737846963701 3.34153417132127e-22 NA NA NA hsa-miR-28-5p TUBGCP5 -0.14267073663385 0.0497619246260571 -0.192566353644787 0.00132433306189554 miRanda -0.107054440107932 0.000173050564531711 NA NA NA hsa-miR-28-5p TXNDC15 -0.14267073663385 0.0497619246260571 -0.12678933462949 0.0100887464640449 miRanda -0.106882127419917 4.56302344280308e-06 NA NA NA hsa-miR-375 UBD 2.09893673049766 1.68351780396203e-16 0.862748226865875 0.00110339433470396 miRanda -0.207354049769643 2.23717504127829e-09 NA NA NA hsa-miR-375 UBE2E2 2.09893673049766 1.68351780396203e-16 -0.604529909585251 4.8825731116358e-09 miRanda -0.141119619746878 3.51026407192711e-26 NA NA NA hsa-miR-28-5p UBE2Z -0.14267073663385 0.0497619246260571 0.531416701885103 1.79902342102429e-16 miRanda -0.126906932637718 4.71304832612847e-05 NA NA NA hsa-miR-28-5p UBE3B -0.14267073663385 0.0497619246260571 -0.04341053843455 0.44320588192684 miRanda -0.20876431830344 2.90771228545953e-15 NA NA NA hsa-miR-28-5p UBTD2 -0.14267073663385 0.0497619246260571 0.128941566560699 0.0252656180967694 miRanda -0.113783835802965 3.10751419447168e-05 NA NA NA hsa-miR-28-5p UBTF -0.14267073663385 0.0497619246260571 0.480221215287978 7.43410138383196e-26 miRanda -0.110317015872406 7.05826550992748e-07 NA NA NA hsa-miR-28-5p ULK3 -0.14267073663385 0.0497619246260571 0.735573512973171 1.0601693976613e-25 miRanda -0.126486106001449 0.000233852849670499 NA NA NA hsa-miR-28-5p URGCP -0.14267073663385 0.0497619246260571 0.0526536004239073 0.285595768643589 miRanda -0.148657531101123 1.3587095350023e-10 NA NA NA hsa-miR-28-5p URM1 -0.14267073663385 0.0497619246260571 0.389004206411093 5.19312203313837e-12 miRanda -0.102999514913133 0.000142527195319968 NA NA NA hsa-miR-28-5p VAV3 -0.14267073663385 0.0497619246260571 1.34411719441904 1.087241773222e-13 miRanda -0.611662799107083 1.47436473807405e-12 NA NA NA hsa-miR-28-5p VEZF1 -0.14267073663385 0.0497619246260571 -0.218442006456705 0.0044599756979924 miRanda -0.163030520501413 7.78947500099617e-06 NA NA NA hsa-miR-28-5p VEZT -0.14267073663385 0.0497619246260571 0.181406259391838 0.0056683713856385 miRanda -0.148894796889565 1.6576465295747e-06 NA NA NA hsa-miR-28-5p VWA3A -0.14267073663385 0.0497619246260571 0.383442103163063 0.125108467711998 miRanda -0.365623168031948 0.00213064702838744 NA NA NA hsa-miR-200a-3p WASF3 2.55218480823434 2.96135446816238e-51 -2.52846175739233 2.89361416346383e-58 miRTarBase -0.405908608720436 7.8748305448137e-40 NA NA NA hsa-miR-200b-3p WASF3 2.11744072703209 1.66710572104191e-43 -2.52846175739233 2.89361416346383e-58 miRTarBase -0.426347852136764 2.62441563344211e-35 NA NA NA hsa-miR-28-5p WBP1 -0.14267073663385 0.0497619246260571 0.580480433955926 7.12747644898469e-17 miRanda -0.227493317147737 9.00615701119687e-12 NA NA NA hsa-miR-28-5p WDR83 -0.14267073663385 0.0497619246260571 0.79199972757636 1.67453700958747e-15 miRanda -0.229298714039308 1.76029336904606e-06 NA NA NA hsa-miR-107 WIF1 0.678998026350662 2.56224148930538e-16 -5.2938799615046 1.46131868175141e-36 miRanda -0.805243011250718 6.66023850485786e-06 NA NA NA hsa-miR-320b WIF1 0.412787504747938 0.00113457276903985 -5.2938799615046 1.46131868175141e-36 miRanda -0.250626959028316 0.0356605312110271 NA NA NA hsa-miR-330-5p WIF1 0.626063225953928 3.42215028606779e-09 -5.2938799615046 1.46131868175141e-36 miRanda -0.660990097984299 2.58056748637709e-06 NA NA NA hsa-miR-342-3p WIF1 1.21944481975657 6.81914373001202e-19 -5.2938799615046 1.46131868175141e-36 miRanda -0.900150959597263 1.15455195350394e-17 NA NA NA hsa-miR-429 WIF1 2.84108892259147 3.88520896426515e-64 -5.2938799615046 1.46131868175141e-36 miRanda -0.57801116079909 1.92906319858818e-12 NA NA NA hsa-miR-590-3p WIF1 1.27438512890514 1.03164723481469e-23 -5.2938799615046 1.46131868175141e-36 miRanda -0.639334008119333 9.64663705878253e-08 NA NA NA hsa-miR-28-5p WIPF2 -0.14267073663385 0.0497619246260571 -0.00735809585132774 0.937520602697966 miRanda -0.134513318957187 0.00257432351610525 NA NA NA hsa-miR-375 WIPF3 2.09893673049766 1.68351780396203e-16 -0.995051311631194 1.88559735333109e-09 miRanda -0.142538214430048 6.68222215853349e-11 NA NA NA hsa-miR-375 YAP1 2.09893673049766 1.68351780396203e-16 -1.31738265371239 9.58372053397518e-43 miRTarBase -0.120107822997014 3.96634849887855e-20 27270433;23685355;20226166;21856745 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer; Knockdown of YAP1 phenocopied miR-375 overexpression and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375;Overexpression of miR 10a and miR 375 and downregulation of YAP1 in medullary thyroid carcinoma; Expression of the potential downstream targets of miR-375 YAP1 a growth inhibitor and SLC16a2 a transporter of thyroid hormone was down-regulated in the tumors suggesting that miR-375 is a negative regulator of the expression of these genes; Furthermore the growth inhibitor YAP1 is identified as a potential important downstream target of miR-375;MicroRNA 375 targets Hippo signaling effector YAP in liver cancer and inhibits tumor properties; The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA miRNA miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients n=48; As determined by luciferase reporter assay we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP; Furthermore immunoblotting revealed miR-375 suppressed endogenous YAP protein level; miR-375 is an important regulator of YAP oncogene implicating a potential therapeutic role in HCC treatment;miR 375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer; The transcriptional coactivator YAP1 was determined to be a direct target of miR-375; YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells ;;; prostate cancer;thyroid cancer;liver cancer;lung cancer hsa-miR-375 YBX1 2.09893673049766 1.68351780396203e-16 -0.123236840794476 0.149132087520584 miRanda -0.12967207547794 4.02018460903968e-33 27466996 MiR 375 is epigenetically downregulated due to promoter methylation and modulates multi drug resistance in breast cancer cells via targeting YBX1; In this study we firstly verified how miR-375 is downregulated in breast cancer cells with multi-drug resistance MDR and further investigated the regulative effect of miR-375 on Ybx1 expression; The binding between miR-375 and YBX1 gene was predicted using Targetscan 7.1 and verified using western blot and dual luciferase assay; MiR-375 can directly target 3'UTR of YBX1 and thereby decrease its expression in MCF-7/ADM and MCF-7/PTX cells; Both miR-375 overexpression and YBX1 knockdown significantly decreased P-gp expression and increased chemosensitivity of the cancer cells; MiR-375 can directly target 3'UTR of YBX1 and thereby decrease its expression which might be an important mechanism of MDR in breast cancer cells drug resistance breast cancer hsa-miR-28-5p YPEL3 -0.14267073663385 0.0497619246260571 0.00907921639306331 0.92452046690186 miRanda -0.197612504863076 1.35986130569366e-05 NA NA NA hsa-miR-330-5p ZBTB16 0.626063225953928 3.42215028606779e-09 -4.63985301217587 2.47816545143769e-48 miRanda -0.92136916694316 5.10140197373554e-18 NA NA NA hsa-miR-455-5p ZBTB16 0.284641224662773 0.0357572339594277 -4.63985301217587 2.47816545143769e-48 miRanda -0.490671612649579 7.35744495702062e-09 NA NA NA hsa-miR-200a-3p ZEB1 2.55218480823434 2.96135446816238e-51 -1.20177694006781 1.58231961737395e-22 miRTarBase -0.319622679415122 1.50005867526347e-44 27402080;23626803;24037528;27402864;23743934;24815002;24424572;20473948;19854497;26887977;24390222;26242262;19544444 Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;;metastasis;;;;tumorigenesis;;;;;metastasis; breast cancer;breast cancer;breast cancer;sarcoma;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;colorectal cancer;prostate cancer hsa-miR-200b-3p ZEB1 2.11744072703209 1.66710572104191e-43 -1.20177694006781 1.58231961737395e-22 miRTarBase -0.340144365122761 1.59273196940771e-40 27402080;26011542;23626803;24037528;24352645;27402864;23743934;24815002;24424572;20473948;19854497;26887977;24390222;27307751;26242262;19544444;26783187 Conversely ectopic expression of miR-200 inhibited this sprouting by indirectly reducing the protein levels of PDGFRβ through the direct suppression of ZEB1;Here we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA miR-200b and miR-429; In 18 clinical tissue samples expression of 53BP1 was positively correlated with miR-200b and mir-429 and negatively correlated with ZEB1;Concomitant with miR-200 decrease there was an increase in ZEB1 mRNA expression; Concomitant with the increase in miR-200b and miR-200c ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition;MiR 200 can repress breast cancer metastasis through ZEB1 independent but moesin dependent pathways;Functional experiments demonstrated that miR-200b suppressed ZEB1 augmented E-cadherin inhibited cell migration and suppressed tumor growth in a mouse model;This circuit comprises the microRNA 200 miR-200 family ZEB1 and GRHL2;This finding was accompanied by a sharp downregulation in the expression of the miR-200 family of microRNAs well-known targets of ZEB1;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;GRHL2 miR 200 ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification;Inhibition of ZEB1 by miR 200 characterizes Helicobacter pylori positive gastric diffuse large B cell lymphoma with a less aggressive behavior; Through genome-wide expression profiles of both miRNAs and mRNAs in nine H pylori-positive and nine H pylori-negative gastric diffuse large B-cell lymphomas we identified inhibition of ZEB1 zinc-finger E-box-binding homeobox 1 by miR-200 in H pylori-positive gastric diffuse large B-cell lymphomas; In 30 H pylori-positive and 30 H pylori-negative gastric diffuse large B-cell lymphomas we confirmed that H pylori-positive gastric diffuse large B-cell lymphomas had higher levels of miR-200 by qRT-PCR and lower levels of ZEB1 and higher levels of BCL6 using immunohistochemistry;MicroRNA 200b acts as a tumor suppressor in osteosarcoma via targeting ZEB1; Moreover ZEB1 was identified as a target gene of miR-200b and its expression levels were negatively mediated by miR-200b in osteosarcoma cells; Based on these findings our study suggests that miR-200b inhibits the proliferation migration and invasion of osteosarcoma cells probably via the inhibition of ZEB1 expression;MiR 200 suppresses metastases of colorectal cancer through ZEB1; Here we showed that the levels of miR-200 were significantly decreased and the levels of ZEB1 were significantly increased in the CRC specimens from patients compared to the paired non-tumor tissue; Moreover the levels of miR-200 and ZEB1 are inversely correlated; Bioinformatics analyses showed that miR-200 targeted the 3'-UTR of ZEB1 mRNA to inhibit its translation which was confirmed by luciferase reporter assay;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;;metastasis;cell migration;;;;tumorigenesis;;;;;;metastasis;;drug resistance breast cancer;breast cancer;breast cancer;breast cancer;gastric cancer;sarcoma;endometrial cancer;sarcoma;head and neck cancer;bladder cancer;ovarian cancer;ovarian cancer;B cell lymphoma;sarcoma;colorectal cancer;prostate cancer;lung squamous cell cancer hsa-miR-200a-3p ZEB2 2.55218480823434 2.96135446816238e-51 -1.60369039498659 1.13296131497065e-43 miRTarBase -0.34961751703046 1.4672767099241e-58 24518294;19787069;24815002;24424572;19854497;21529905;19544444;25797260 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E cadherin repressor ZEB2; The 3'-UTR of ZEB2 mRNA a transcriptional repressor of E-cadherin was found to be regulated directly by miR-200a; Our results suggest that loss of expression of miR-200a may play a critical role in the repression of E-cadherin by ZEB2 thereby enhancing migration and invasion in CD133/1+ cells;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2;MicroRNA 200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2; Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2; The associations between miR-200a SP cells and ZEB2 were validated in HCC; These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2 ;metastasis;;tumorigenesis;;;;metastasis breast cancer;breast cancer;sarcoma;head and neck cancer;ovarian cancer;ovarian cancer;prostate cancer;liver cancer hsa-miR-200b-3p ZEB2 2.11744072703209 1.66710572104191e-43 -1.60369039498659 1.13296131497065e-43 miRTarBase -0.387016799530245 6.18770056114522e-58 24518294;19787069;24815002;24424572;24769353;19854497;22311119;19544444 This switch involved activation of the transforming growth factor-β TGFβ signaling network that led to a shift in the balance between miR-200 microRNAs and the transcription factor zinc finger E-box-binding homeobox 2 ZEB2 resulting in suppressed transcription of the gene encoding E-cadherin;These findings are surprising since the miR-200 family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression; Expression of miR-200 which promotes a mesenchymal to epithelial cell transition MET by inhibiting Zeb2 expression unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines;Moreover a series of loss-of-function and gain-of-function experiments further indicated that busulfan may have its anti-osteosarcoma effect by upregulating the microRNA-200 miR-200 family which subsequently downregulated its target genes ZEB1 and ZEB2;Furthermore our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis;Zinc finger E box binding homeobox 2 ZEB2 regulated by miR 200b contributes to multi drug resistance of small cell lung cancer; In silico analysis demonstrated that there are complementary binding sites between miR-200b and ZEB2 3'-UTR and identified miR-200b as a potential regulator of ZEB2; Overexpression of miR-200b led to the downregulation of ZEB2 at protein level; Luciferase reporter gene assay showed that 3'UTR ZEB2 activity was regulated by miR-200b; Our results suggest that ZEB2 modulates drug resistance and is regulated by miR-200b;We used qRT-PCR to examine expression of the miR-200 miRNA family and its predicted targets the ZEB1 and ZEB2 transcriptional repressors in primary cultures of normal cells from the surface of the ovary and in a panel of 70 ovarian cancer tissues and 15 ovarian cancer cell lines; We studied the mechanisms of regulation of miR-200 miRNAs and ZEB transcription factors in ovarian cells using 3' UTR luciferase reporters promoter luciferase reporters and siRNAs miR-200 family members are expressed at low or negligible levels in normal ovarian surface cells and substantially increase in expression in ovarian cancer whereas expression of ZEB1 and ZEB2 shows the opposite pattern;MicroRNA 200b regulates cell proliferation invasion and migration by directly targeting ZEB2 in gastric carcinoma; There was a strong correlation between the levels of miR-200b and ZEB2 and E-cadherin mRNAs in gastric cancer patients; miR-200b regulates ZEB2 expression and thus controls metastasis in gastric cancer;Recent studies have shown that the miR-200 family regulates epithelial-mesenchymal transition EMT by targeting zinc-finger E-box binding homeobox 1 ZEB1 and ZEB2 ;metastasis;;tumorigenesis;drug resistance;;metastasis; breast cancer;breast cancer;sarcoma;head and neck cancer;lung squamous cell cancer;ovarian cancer;gastric cancer;prostate cancer hsa-miR-375 ZEB2 2.09893673049766 1.68351780396203e-16 -1.60369039498659 1.13296131497065e-43 miRanda -0.141650858820113 2.73776967382215e-19 NA NA NA hsa-miR-28-5p ZFHX3 -0.14267073663385 0.0497619246260571 -0.348999974902257 0.000181853915066663 miRanda -0.167550170989698 0.000163066442653836 NA NA NA hsa-miR-375 ZFP36L2 2.09893673049766 1.68351780396203e-16 -1.20951272849442 2.78264800572534e-33 miRanda -0.138680538757387 5.26048421392882e-25 NA NA NA hsa-miR-28-5p ZFP62 -0.14267073663385 0.0497619246260571 0.325545168406013 2.86196637656788e-07 miRanda -0.13865357278194 4.53335257114054e-06 NA NA NA hsa-miR-200a-3p ZFPM2 2.55218480823434 2.96135446816238e-51 -1.48309651759718 5.26430774358294e-23 miRTarBase -0.372246535238814 3.0832686353886e-40 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-200b-3p ZFPM2 2.11744072703209 1.66710572104191e-43 -1.48309651759718 5.26430774358294e-23 miRTarBase -0.40035042800184 1.77712326643107e-37 26314828 It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 friend of GATA 2 which directly binds to the p85α regulatory subunit of PI3K lung cancer hsa-miR-28-5p ZFYVE21 -0.14267073663385 0.0497619246260571 -0.367598845555907 7.77046925532795e-09 miRanda -0.132662159289845 1.30742694588055e-05 NA NA NA hsa-miR-28-5p ZFYVE26 -0.14267073663385 0.0497619246260571 -0.327493136832778 2.35759136357908e-07 miRanda -0.12447247393372 3.86452573331125e-05 NA NA NA hsa-miR-375 ZIC1 2.09893673049766 1.68351780396203e-16 0.188842363843119 0.617056839930357 miRanda -0.418569057856771 1.02917524809615e-17 NA NA NA hsa-miR-375 ZIC5 2.09893673049766 1.68351780396203e-16 -0.155330414624192 0.63062439709307 miRanda -0.194325505793052 4.62657032376942e-06 NA NA NA hsa-miR-28-5p ZNF141 -0.14267073663385 0.0497619246260571 -0.339631252919259 3.05959108622568e-05 miRanda -0.125874933389015 0.00121089813530106 NA NA NA hsa-miR-28-5p ZNF19 -0.14267073663385 0.0497619246260571 -0.231757613225705 0.0028772583683754 miRanda -0.153894344201966 3.11401369237391e-05 NA NA NA hsa-miR-28-5p ZNF217 -0.14267073663385 0.0497619246260571 0.418864365129461 2.53498724711067e-05 miRanda -0.153414197347742 0.00124263968059985 NA NA NA hsa-miR-375 ZNF462 2.09893673049766 1.68351780396203e-16 -1.85020093931925 1.93274868933039e-26 miRanda -0.233090473292586 4.63942888439584e-24 NA NA NA hsa-miR-28-5p ZNF483 -0.14267073663385 0.0497619246260571 -1.79302155637936 8.09598164766452e-31 miRanda -0.161877451760601 0.0353741074383505 NA NA NA hsa-miR-28-5p ZNF484 -0.14267073663385 0.0497619246260571 -0.394911538640617 4.74176735844624e-05 miRanda -0.157201362671009 0.000693734308711223 NA NA NA hsa-miR-28-5p ZNF584 -0.14267073663385 0.0497619246260571 0.083372296410301 0.142227608562401 miRanda -0.162509824661307 1.23349297245691e-09 NA NA NA hsa-miR-28-5p ZNF609 -0.14267073663385 0.0497619246260571 0.093745834360889 0.193677156970303 miRanda -0.17454071384802 3.08415035241991e-07 NA NA NA hsa-miR-28-5p ZNF615 -0.14267073663385 0.0497619246260571 -0.448908283415558 5.52841871038806e-08 miRanda -0.109992140552008 0.00550144078708249 NA NA NA hsa-miR-28-5p ZNF626 -0.14267073663385 0.0497619246260571 -0.000772536290166048 0.995647761387273 miRanda -0.220256116308172 0.00107200384839584 NA NA NA hsa-miR-155-5p ZNF652 1.09766314984151 4.55650930885814e-15 0.213841843999925 0.0221268421718162 miRTarBase -0.112251324589659 5.36172306133945e-07 22797073 A search for cancer-related target genes of miR-155 revealed ZNF652 a novel zinc-finger transcriptional repressor breast cancer hsa-miR-28-5p ZNF655 -0.14267073663385 0.0497619246260571 -0.550879158758876 1.1977452132855e-09 miRanda -0.10696179348568 0.0141009676103873 NA NA NA hsa-miR-28-5p ZNF665 -0.14267073663385 0.0497619246260571 -0.612934521530682 2.18611918652348e-07 miRanda -0.165068213448631 0.00360053988165736 NA NA NA hsa-miR-28-5p ZNF689 -0.14267073663385 0.0497619246260571 -0.187666926528026 0.172159706978396 miRanda -0.251518404206901 0.000117526224448517 NA NA NA hsa-miR-28-5p ZNF740 -0.14267073663385 0.0497619246260571 -0.0891625358082004 0.165860174035839 miRanda -0.157571961321932 2.19054782197219e-07 NA NA NA hsa-miR-28-5p ZNF764 -0.14267073663385 0.0497619246260571 0.751807638397205 5.3087214361303e-34 miRanda -0.230605997304356 2.28319062007636e-14 NA NA NA hsa-miR-28-5p ZSCAN29 -0.14267073663385 0.0497619246260571 0.00304067676335418 0.961086390220188 miRanda -0.102988503595859 0.000492546003786681 NA NA NA hsa-miR-28-5p ZSWIM5 -0.14267073663385 0.0497619246260571 -0.451593352623076 0.00950484344118356 miRanda -0.585836577748603 9.01191284628358e-13 NA NA NA