miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-15a-5p CAB39 0.349521211668244 0.000770735998804736 -0.152804524606349 0.00962811714746276 miRNATAP -0.108425253583809 7.85731490720904e-05 NA NA NA hsa-miR-16-1-3p CAB39 0.392360028038559 0.00112481918108198 -0.152804524606349 0.00962811714746276 MirTarget -0.117268659952457 5.98270638213691e-07 NA NA NA hsa-miR-193a-3p CAB39 -0.117675551589896 0.309391958208578 -0.152804524606349 0.00962811714746276 MirTarget;miRanda -0.123942945247746 4.68902843877997e-07 NA NA NA hsa-miR-192-3p CAB39L -0.6401165114007 0.000266272092403814 -0.504869726858055 1.1927547950473e-05 mirMAP -0.122781017802891 0.0001220181908619 NA NA NA hsa-miR-192-5p CAB39L -0.50188499512787 0.00344713341196035 -0.504869726858055 1.1927547950473e-05 miRNAWalker2_validate -0.168189458314805 2.40399921852626e-07 NA NA NA hsa-miR-361-5p CAB39L 0.233202959858696 0.00961572812255327 -0.504869726858055 1.1927547950473e-05 MirTarget;miRanda -0.195565910720272 0.00208448717872423 NA NA NA hsa-miR-362-3p CAB39L 0.814007335895913 2.00108618836568e-09 -0.504869726858055 1.1927547950473e-05 miRanda -0.153089959329449 0.000183470156830685 NA NA NA hsa-miR-618 CAB39L 0.13539895350352 0.517145913114103 -0.504869726858055 1.1927547950473e-05 mirMAP -0.10129028583161 0.000298566594868403 NA NA NA hsa-miR-30d-5p DDIT4 0.718283816348023 2.47422074061352e-08 0.228443977506799 0.236844454905723 MirTarget;miRNATAP -0.20537756673444 0.00438989200660324 NA NA NA hsa-miR-32-5p DDIT4 0.0806126674664016 0.548984992497432 0.228443977506799 0.236844454905723 miRNATAP -0.199880895095326 0.00445876889151134 NA NA NA hsa-miR-92a-3p DDIT4 0.212391012518195 0.134292268089997 0.228443977506799 0.236844454905723 miRNATAP -0.182713424395714 0.00604393810305066 NA NA NA hsa-miR-330-5p EIF4B 0.442231058604099 0.0053308560843808 -0.213371036122907 0.00927846005206924 miRNATAP -0.121583930567148 1.00720259566484e-06 NA NA NA hsa-miR-339-5p EIF4B 0.280589919878422 0.0355660282647215 -0.213371036122907 0.00927846005206924 miRanda -0.131202132226587 1.04386561466155e-05 NA NA NA hsa-miR-342-3p EIF4B -0.319677314984262 0.0449813878317147 -0.213371036122907 0.00927846005206924 miRanda -0.127381134711691 2.69280086896855e-07 NA NA NA hsa-miR-362-3p EIF4B 0.814007335895913 2.00108618836568e-09 -0.213371036122907 0.00927846005206924 miRanda -0.120133065959791 2.94856447934838e-05 NA NA NA hsa-miR-484 EIF4B 0.0857240033709656 0.453982056282229 -0.213371036122907 0.00927846005206924 miRNAWalker2_validate -0.156463221852403 7.2363961844545e-06 NA NA NA hsa-miR-497-5p EIF4B -1.41371173021948 7.09278946477743e-17 -0.213371036122907 0.00927846005206924 miRNATAP -0.103808529523177 3.87646612451936e-06 NA NA NA hsa-miR-107 EIF4E 0.241662461253461 0.0170788899505389 -0.423618150345152 8.76394952666589e-09 miRanda -0.145690630779375 5.10144854982989e-05 NA NA NA hsa-miR-25-3p EIF4E 0.633062563556379 3.68686354834328e-10 -0.423618150345152 8.76394952666589e-09 mirMAP -0.120897171896447 0.000649613904023936 NA NA NA hsa-miR-500a-3p EIF4E 1.18913245435489 1.59516890341346e-16 -0.423618150345152 8.76394952666589e-09 MirTarget -0.100990657027664 2.96319587641026e-05 NA NA NA hsa-miR-660-5p EIF4E 0.989755850734071 5.69930767464937e-14 -0.423618150345152 8.76394952666589e-09 mirMAP -0.155553210664168 3.85299588654816e-09 NA NA NA hsa-miR-140-5p EIF4E2 -0.220106443070144 0.0140713197101242 -0.0307165992319307 0.660560144350934 miRanda -0.138995836241305 0.000258086393762208 NA NA NA hsa-miR-29a-3p EIF4E2 -0.856762511178136 4.65330336378459e-12 -0.0307165992319307 0.660560144350934 MirTarget -0.113597041826362 1.87271499311999e-05 NA NA NA hsa-miR-125b-5p EIF4EBP1 -1.35767721102906 1.16564617395164e-18 -0.0296151122465442 0.838078981735608 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.116832363024321 0.00778246256108478 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-107 HIF1A 0.241662461253461 0.0170788899505389 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;miRanda -0.436710343430652 2.03313957855482e-10 NA NA NA hsa-miR-17-5p HIF1A 0.698861147045461 2.43854106455398e-05 -0.366176828296648 0.0111002186054683 miRTarBase;MirTarget;TargetScan -0.207486649592262 6.73419034465465e-07 NA NA NA hsa-miR-20a-5p HIF1A 0.854326758727003 5.04256669663285e-07 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;MirTarget -0.245558453559623 9.83134714947215e-10 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-33a-5p HIF1A -0.767474460958522 1.09948756118522e-05 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate -0.107227499920455 0.00730487730363833 NA NA NA hsa-miR-616-5p HIF1A 0.150569904638223 0.402836556304524 -0.366176828296648 0.0111002186054683 MirTarget -0.124976106072862 0.00144238259369066 NA NA NA hsa-miR-660-5p HIF1A 0.989755850734071 5.69930767464937e-14 -0.366176828296648 0.0111002186054683 MirTarget -0.249870386379118 1.21860559731773e-06 NA NA NA hsa-miR-93-5p HIF1A 1.39518349670953 2.84167728726712e-25 -0.366176828296648 0.0111002186054683 MirTarget -0.173769064325932 0.000425501783480084 NA NA NA hsa-miR-103a-2-5p IGF1 1.17085533927423 5.31418969120877e-09 -3.09093589123239 2.87389370715384e-21 mirMAP -0.263504392304743 0.00223342792049484 NA NA NA hsa-miR-15b-3p IGF1 0.238105490431193 0.0997721500357416 -3.09093589123239 2.87389370715384e-21 mirMAP -0.317736514699582 0.00624882495536213 NA NA NA hsa-miR-181a-5p IGF1 0.250113435902954 0.0551933249319293 -3.09093589123239 2.87389370715384e-21 mirMAP -0.504463915639783 8.50109868625984e-05 NA NA NA hsa-miR-181b-5p IGF1 0.488256489401108 0.00105321129419701 -3.09093589123239 2.87389370715384e-21 mirMAP -0.623738116833257 1.69561535563835e-08 NA NA NA hsa-miR-19a-3p IGF1 1.01712596153672 2.57753201450625e-07 -3.09093589123239 2.87389370715384e-21 MirTarget -0.400144846493838 1.38857829477185e-06 NA NA NA hsa-miR-19b-3p IGF1 0.601279551368824 0.00016685097085251 -3.09093589123239 2.87389370715384e-21 MirTarget -0.48361890440052 2.97870836726975e-06 NA NA NA hsa-miR-20a-3p IGF1 -0.318177901603857 0.0467885456739855 -3.09093589123239 2.87389370715384e-21 mirMAP -0.361896843485159 0.00054680673837891 NA NA NA hsa-miR-301a-3p IGF1 0.842910511640361 1.43446467417891e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.644215183857533 3.25465618219484e-12 NA NA NA hsa-miR-3913-5p IGF1 0.247553671224336 0.062795011081188 -3.09093589123239 2.87389370715384e-21 mirMAP -0.347700367785319 0.00609623314715803 NA NA NA hsa-miR-421 IGF1 0.941856334694081 6.12167297054077e-08 -3.09093589123239 2.87389370715384e-21 PITA -0.472083397878338 5.5786740474017e-07 NA NA NA hsa-miR-454-3p IGF1 0.668749059573955 2.42670710515113e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.659716525935208 1.08682616687143e-08 NA NA NA hsa-miR-940 IGF1 0.453020092551484 0.0177054921651997 -3.09093589123239 2.87389370715384e-21 MirTarget;PITA;miRNATAP -0.258190444399689 0.00419588966919949 NA NA NA hsa-miR-106a-5p PDPK1 -0.464229535269236 0.009724944358047 0.309856812256619 0.0145897035970451 mirMAP -0.106603481622112 0.00191993221102484 NA NA NA hsa-miR-22-5p PDPK1 -0.630365901263172 3.32415348030414e-05 0.309856812256619 0.0145897035970451 miRNATAP -0.114858817985206 0.004539264565349 NA NA NA hsa-miR-24-3p PDPK1 -0.257825594021966 0.00689742600215061 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.189377775001018 0.00377818335280003 NA NA NA hsa-miR-27a-3p PDPK1 -0.370807380415112 0.00875721956202713 0.309856812256619 0.0145897035970451 miRNATAP -0.12746674939881 0.00357863446842311 NA NA NA hsa-miR-324-3p PDPK1 0.260348469146494 0.0506141704203545 0.309856812256619 0.0145897035970451 mirMAP -0.133875113382166 0.00407187982303137 NA NA NA hsa-miR-326 PDPK1 -1.881935132554 1.68087316863775e-21 0.309856812256619 0.0145897035970451 mirMAP -0.115285864383535 0.000115621382458437 NA NA NA hsa-miR-330-3p PDPK1 -0.332364259424489 0.0316051913061459 0.309856812256619 0.0145897035970451 mirMAP -0.199719327448706 8.51522334736582e-07 NA NA NA hsa-miR-330-5p PDPK1 0.442231058604099 0.0053308560843808 0.309856812256619 0.0145897035970451 mirMAP -0.174352569124449 6.44046033884862e-06 NA NA NA hsa-miR-331-3p PDPK1 -0.283974346994635 0.0373785411053202 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.14393772894958 0.0015300062995931 NA NA NA hsa-miR-342-3p PDPK1 -0.319677314984262 0.0449813878317147 0.309856812256619 0.0145897035970451 mirMAP -0.202682473172801 1.2852571763811e-07 NA NA NA hsa-miR-424-5p PDPK1 -2.62653257498508 2.38997974737991e-50 0.309856812256619 0.0145897035970451 mirMAP -0.106052465451978 0.000611771334502943 NA NA NA hsa-miR-542-3p PDPK1 -1.31351015149842 3.64642423288576e-22 0.309856812256619 0.0145897035970451 mirMAP -0.149412531526728 0.000555422280439471 NA NA NA hsa-miR-744-5p PDPK1 -0.378868377317939 0.00125071229180016 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.143178711893691 0.0067023429085085 NA NA NA hsa-miR-766-3p PDPK1 0.199979324759329 0.257230732626744 0.309856812256619 0.0145897035970451 mirMAP -0.152946333354899 1.15508230226764e-05 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-107 PIK3R5 0.241662461253461 0.0170788899505389 -0.89989526759384 1.62789758196776e-07 miRanda -0.349504238477674 3.20976138937126e-05 NA NA NA hsa-miR-15a-5p PRKAA1 0.349521211668244 0.000770735998804736 -0.60864021207068 5.26267892833978e-12 MirTarget -0.127934215917556 0.00259652352236475 NA NA NA hsa-let-7b-3p PRKAA2 -1.21979213547786 5.84575581584603e-17 0.910177606708893 0.0133266185680845 mirMAP -0.385703556647416 0.00114946510675726 NA NA NA hsa-let-7b-5p PRKAA2 -0.959013717270803 5.95127281258643e-11 0.910177606708893 0.0133266185680845 miRNAWalker2_validate;MirTarget -0.399590032732691 0.000857606952583238 NA NA NA hsa-let-7c-5p PRKAA2 -1.70744661345097 2.87934212005942e-20 0.910177606708893 0.0133266185680845 MirTarget -0.323478962357034 0.000457014156060023 NA NA NA hsa-miR-125b-5p PRKAA2 -1.35767721102906 1.16564617395164e-18 0.910177606708893 0.0133266185680845 miRNATAP -0.468131740207186 2.58447444857568e-05 NA NA NA hsa-miR-130a-3p PRKAA2 -1.53229181736223 2.91460363624872e-19 0.910177606708893 0.0133266185680845 MirTarget -0.261650172386151 0.00937218581418371 NA NA NA hsa-miR-130b-3p PRKAA2 0.687190305027546 0.000109068658562255 0.910177606708893 0.0133266185680845 MirTarget -0.39214943725483 8.93727722972995e-05 NA NA NA hsa-miR-139-5p PRKAA2 -2.11299531796557 8.16407076415038e-28 0.910177606708893 0.0133266185680845 mirMAP -0.243840459298225 0.00500077362975578 NA NA NA hsa-miR-144-3p PRKAA2 -2.97536914478815 6.00546047309683e-28 0.910177606708893 0.0133266185680845 mirMAP -0.251212728741441 4.29127796324217e-05 NA NA NA hsa-miR-16-2-3p PRKAA2 -0.0336420826463706 0.805158952566973 0.910177606708893 0.0133266185680845 mirMAP -0.457570769127741 0.000536483503983079 NA NA NA hsa-miR-195-3p PRKAA2 -1.09375690196245 4.70092324819807e-09 0.910177606708893 0.0133266185680845 mirMAP -0.528536254111941 2.17986726272341e-08 NA NA NA hsa-miR-203a-3p PRKAA2 -1.34362479226226 8.69374456831293e-05 0.910177606708893 0.0133266185680845 MirTarget -0.179382015471783 0.000540688920660811 NA NA NA hsa-miR-217 PRKAA2 1.05797297540381 0.0401026692682422 0.910177606708893 0.0133266185680845 mirMAP -0.174781811555677 3.64856315207684e-07 NA NA NA hsa-miR-22-5p PRKAA2 -0.630365901263172 3.32415348030414e-05 0.910177606708893 0.0133266185680845 mirMAP -0.407034919675641 0.000519823954254811 NA NA NA hsa-miR-26a-5p PRKAA2 -0.963792031426845 1.83360999387345e-22 0.910177606708893 0.0133266185680845 mirMAP -0.782511241662933 5.79168652076068e-06 NA NA NA hsa-miR-30e-3p PRKAA2 -1.20845647373031 3.10263633528203e-25 0.910177606708893 0.0133266185680845 MirTarget -0.527801395071765 0.000287963362506242 NA NA NA hsa-miR-628-3p PRKAA2 -0.958478775877672 6.18965095549213e-08 0.910177606708893 0.0133266185680845 mirMAP -0.30159363325766 0.00298084973196401 NA NA NA hsa-miR-542-3p RHEB -1.31351015149842 3.64642423288576e-22 0.594343190335174 8.4076096236034e-15 miRanda -0.154397416399753 5.84623305682461e-09 NA NA NA hsa-miR-16-1-3p RICTOR 0.392360028038559 0.00112481918108198 -0.237765548278541 0.0047022112792698 MirTarget -0.107553049046612 0.00155488864096036 NA NA NA hsa-miR-660-5p RICTOR 0.989755850734071 5.69930767464937e-14 -0.237765548278541 0.0047022112792698 MirTarget -0.124145467768421 3.66585982170959e-05 NA NA NA hsa-miR-99a-5p RPS6 -1.51481656384839 3.93230057259529e-14 0.185885010447493 0.120916808338817 miRNAWalker2_validate -0.141086052819295 4.22214050226356e-07 NA NA NA hsa-miR-17-5p RPS6KA1 0.698861147045461 2.43854106455398e-05 -0.0193982843076919 0.895272926505225 TargetScan;miRNATAP -0.150479492101603 0.000442310908893647 NA NA NA hsa-miR-20a-5p RPS6KA1 0.854326758727003 5.04256669663285e-07 -0.0193982843076919 0.895272926505225 miRNATAP -0.140420093444226 0.000724052018701145 NA NA NA hsa-miR-130b-5p RPS6KA2 0.170599813152408 0.337611586432771 -0.429936688183553 0.00940192295734202 mirMAP -0.213305958673466 2.2886761501014e-06 NA NA NA hsa-miR-17-5p RPS6KA2 0.698861147045461 2.43854106455398e-05 -0.429936688183553 0.00940192295734202 TargetScan -0.361293542462631 1.51868565926867e-14 NA NA NA hsa-miR-192-3p RPS6KA2 -0.6401165114007 0.000266272092403814 -0.429936688183553 0.00940192295734202 mirMAP -0.190995022600123 2.73504188366536e-05 NA NA NA hsa-miR-193a-3p RPS6KA2 -0.117675551589896 0.309391958208578 -0.429936688183553 0.00940192295734202 mirMAP -0.302358304666807 1.53272294304117e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 1.01712596153672 2.57753201450625e-07 -0.429936688183553 0.00940192295734202 MirTarget -0.190446066307176 1.94564659739969e-06 NA NA NA hsa-miR-19b-3p RPS6KA2 0.601279551368824 0.00016685097085251 -0.429936688183553 0.00940192295734202 MirTarget -0.235922153431053 2.30069900396003e-06 NA NA NA hsa-miR-30d-5p RPS6KA2 0.718283816348023 2.47422074061352e-08 -0.429936688183553 0.00940192295734202 MirTarget;miRNATAP -0.222191844967225 0.000323873436695374 NA NA NA hsa-miR-3127-5p RPS6KA2 0.837385386388614 2.06679743975142e-07 -0.429936688183553 0.00940192295734202 mirMAP -0.204709957034024 3.28185871635773e-05 NA NA NA hsa-miR-532-3p RPS6KA2 0.297601533259956 0.014632205884815 -0.429936688183553 0.00940192295734202 MirTarget;mirMAP -0.296357914442727 7.3133532891582e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.18593770505086 1.01781241960531e-22 -0.429936688183553 0.00940192295734202 mirMAP -0.412829583412935 3.43368368308291e-11 NA NA NA hsa-miR-93-3p RPS6KA2 0.402821129107592 0.00131324842735588 -0.429936688183553 0.00940192295734202 MirTarget -0.482383363283909 1.2839051401815e-14 NA NA NA hsa-miR-181c-5p RPS6KA3 -0.00639394152050299 0.969127212255928 -0.0721830047612428 0.620235959053163 MirTarget;mirMAP;miRNATAP -0.132982978659169 0.00196775794236537 NA NA NA hsa-miR-497-5p RPS6KA3 -1.41371173021948 7.09278946477743e-17 -0.0721830047612428 0.620235959053163 MirTarget;miRNATAP -0.106167734324023 0.00837538561255109 NA NA NA hsa-miR-126-5p RPS6KB1 -0.428561469405594 6.6035585844222e-05 0.0405513114293425 0.579068505304799 mirMAP -0.106946073918378 0.00114467289374143 NA NA NA hsa-miR-145-5p RPS6KB1 -1.4795885711477 6.47308361543414e-16 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.109724019103871 2.07298188703538e-09 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-181a-5p RPS6KB1 0.250113435902954 0.0551933249319293 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.116671963226395 1.5972465565874e-05 NA NA NA hsa-miR-181c-5p RPS6KB1 -0.00639394152050299 0.969127212255928 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.10835890138279 3.360156885851e-07 NA NA NA hsa-miR-27a-3p RPS6KB1 -0.370807380415112 0.00875721956202713 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.13716383977936 2.72226167197111e-08 NA NA NA hsa-miR-342-3p RPS6KB1 -0.319677314984262 0.0449813878317147 0.0405513114293425 0.579068505304799 miRanda -0.115090266357129 1.55784431831661e-07 NA NA NA hsa-miR-542-3p RPS6KB1 -1.31351015149842 3.64642423288576e-22 0.0405513114293425 0.579068505304799 miRNATAP -0.102388373747613 3.28524227017976e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.91219969372382 1.38256246489548e-07 0.230775242252044 0.00570601482278892 miRanda -0.115997614156545 4.04919339586598e-07 NA NA NA hsa-miR-140-5p STRADA -0.220106443070144 0.0140713197101242 0.498302253980222 3.82764636239296e-12 miRanda -0.120688525055184 0.00273933234610203 NA NA NA hsa-miR-542-3p STRADA -1.31351015149842 3.64642423288576e-22 0.498302253980222 3.82764636239296e-12 miRanda -0.17474859665732 8.10925851097995e-13 NA NA NA hsa-miR-10a-5p TSC1 -1.47723516092033 7.27299669108673e-16 0.920881916944059 1.33648384372723e-19 mirMAP -0.139629452664737 2.24435503048579e-07 NA NA NA hsa-miR-139-5p TSC1 -2.11299531796557 8.16407076415038e-28 0.920881916944059 1.33648384372723e-19 mirMAP -0.138969507847749 1.79604322012115e-08 NA NA NA hsa-miR-142-3p TSC1 -1.4243101967815 1.92609481097765e-14 0.920881916944059 1.33648384372723e-19 miRanda -0.126618039733337 2.13468537583732e-06 NA NA NA hsa-miR-195-3p TSC1 -1.09375690196245 4.70092324819807e-09 0.920881916944059 1.33648384372723e-19 mirMAP -0.102350213332177 0.000197504018678128 NA NA NA hsa-miR-335-5p TSC1 -1.61347836513558 1.62757083289711e-19 0.920881916944059 1.33648384372723e-19 miRNAWalker2_validate -0.127585694708462 3.44981987359883e-06 NA NA NA hsa-miR-3614-5p TSC1 -1.66311416965679 1.26647181860439e-15 0.920881916944059 1.33648384372723e-19 mirMAP -0.106465716187074 1.0480173495806e-05 NA NA NA hsa-miR-450b-5p TSC1 -1.34333360369432 2.68386079790462e-17 0.920881916944059 1.33648384372723e-19 mirMAP -0.130360378995634 2.9321967866797e-05 NA NA NA hsa-miR-542-3p TSC1 -1.31351015149842 3.64642423288576e-22 0.920881916944059 1.33648384372723e-19 PITA;miRanda -0.198207156237058 3.1659040994906e-08 NA NA NA hsa-miR-744-5p TSC2 -0.378868377317939 0.00125071229180016 0.454638169130336 1.34709422274577e-05 miRNAWalker2_validate -0.146650115106937 0.000784576818042153 NA NA NA hsa-miR-10b-3p ULK2 2.77189254628215 2.26687582932628e-20 -0.751057335334513 0.00080135979131828 MirTarget -0.148313505499471 7.61598951514493e-05 NA NA NA hsa-miR-130b-3p ULK2 0.687190305027546 0.000109068658562255 -0.751057335334513 0.00080135979131828 MirTarget -0.255363263740498 2.88541774955778e-05 NA NA NA hsa-miR-150-5p VEGFA -1.14624309254329 1.51365525978726e-06 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase -0.114666527453602 2.4663414134099e-07 NA NA NA hsa-miR-29b-2-5p VEGFA -0.223258653034772 0.084306146519938 0.0263183839451075 0.81382635000524 MirTarget -0.132006150652748 0.00171675395806506 NA NA NA hsa-miR-29b-3p VEGFA -0.348885528720517 0.0121441341291285 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase;MirTarget -0.125790856471025 0.00126089778683366 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-128-3p VEGFC 0.289735108018712 0.0114419474207889 0.0031169028254141 0.982787493023474 miRNAWalker2_validate;MirTarget -0.198618366596319 0.00124097531466772 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC -0.0336420826463706 0.805158952566973 0.0031169028254141 0.982787493023474 MirTarget -0.149514000508957 0.00387572506927192 NA NA NA hsa-miR-374a-5p VEGFC 0.016390363747302 0.869784217438621 0.0031169028254141 0.982787493023474 MirTarget -0.28522635078723 5.53265846690998e-05 NA NA NA hsa-miR-374b-5p VEGFC -0.307538028546424 0.0030079617545972 0.0031169028254141 0.982787493023474 MirTarget -0.209454919974677 0.00209421071373184 NA NA NA hsa-miR-590-3p VEGFC -0.473167498047808 1.76652934637227e-05 0.0031169028254141 0.982787493023474 miRanda -0.274821384359749 1.36978001441178e-05 NA NA NA