miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-let-7a-5p	CCR7	0.618599506841644	2.76973453058748e-05	0.430877670843034	0.494648405448519	miRTarBase;TargetScan;miRNATAP	-0.613154415611815	0.00343131757869265	22251626	In the present study the authors demonstrated that microRNA miRNA let-7a downregulates CCR7 expression and directly influences the migration and invasion of breast cancer cells; The expression of CCR7 its ligand CCL21 and let-7a was detected in breast cancer cell lines and in breast cancer patient tissues; To confirm the fact that 3'UTR of CCR7 is a direct target of let-7a a luciferase assay for the reporter gene expressing the let-7a binding sites of CCR7 3'UTR was used; In addition a reverse correlation in the expression of CCR7 and let-7a in breast cancer cell lines and breast cancer patient tissues was detected; Synthetic let-7a decreased breast cancer cell proliferation migration and invasion as well as CCR7 protein expression in MDA-MB-231 cells; The 3'UTR of CCR7 was confirmed as a direct target of let-7a by using the luciferase assay for the reporter gene expressing let-7a CCR7 3'UTR binding sites; The results from the present study suggest that targeting of CCL21-CCR7 signaling is a valid approach for breast cancer therapy and that let-7a directly binds to the 3'UTR of CCR7 and blocks its protein expression thereby suppressing migration and invasion of human breast cancer cells		breast cancer
hsa-let-7b-5p	CCR7	0.604314269683977	0.00140009936153214	0.430877670843034	0.494648405448519	miRNATAP	-0.683422752521051	2.32614237448e-05		NA	NA	NA