miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ABI3BP -0.121070851008387 0.198381281894242 -0.534795618369756 0.000505432877203386 miRanda -0.331156428904253 1.02598240124935e-05 NA NA NA hsa-miR-137 ABI3BP -0.924849266740909 1.546832202049e-06 -0.534795618369756 0.000505432877203386 PITA;miRanda;miRNATAP -0.165375436459959 1.20653642028806e-06 NA NA NA hsa-miR-146b-5p ABI3BP 0.441078059667297 0.000237619929889385 -0.534795618369756 0.000505432877203386 miRanda -0.286363289170686 7.84915129257567e-07 NA NA NA hsa-miR-181b-5p ABI3BP 0.0260899284211646 0.768941836912518 -0.534795618369756 0.000505432877203386 miRNATAP -0.27390541019478 0.00371065976480711 NA NA NA hsa-miR-34c-5p ABI3BP 0.181931113688093 0.257266965617363 -0.534795618369756 0.000505432877203386 miRanda -0.131304455453991 0.00146104562302456 NA NA NA hsa-miR-369-3p ABI3BP -0.153496605399658 0.296055925448078 -0.534795618369756 0.000505432877203386 miRNATAP -0.205760341788333 5.98025800353074e-06 NA NA NA hsa-miR-508-3p ABI3BP -0.292045725850845 0.0158994578296519 -0.534795618369756 0.000505432877203386 PITA -0.22528823282091 3.98664948929983e-05 NA NA NA hsa-miR-664a-3p ABI3BP 0.0413918462467198 0.611334357897022 -0.534795618369756 0.000505432877203386 mirMAP -0.333526624667419 7.57610799708692e-05 NA NA NA hsa-miR-129-5p ADAM12 -0.567133990117126 0.00116152215679936 1.04394410405498 1.19114934803854e-12 miRanda;mirMAP -0.177528935762411 3.50954524051505e-06 NA NA NA hsa-miR-139-5p ADAM12 -0.647754756897633 2.15378307237163e-06 1.04394410405498 1.19114934803854e-12 miRanda -0.303198930124896 5.76662396891947e-10 NA NA NA hsa-miR-3065-5p ADAM12 -0.262608140481507 0.0414570974148034 1.04394410405498 1.19114934803854e-12 mirMAP -0.237880577820958 3.12385247700789e-06 NA NA NA hsa-miR-338-3p ADAM12 -0.39963704679384 0.0034410643220691 1.04394410405498 1.19114934803854e-12 miRanda -0.161973854683175 0.00220324033086378 NA NA NA hsa-miR-346 ADAM12 -0.577786425963268 2.10883270131593e-09 1.04394410405498 1.19114934803854e-12 PITA;miRanda -0.43496493693887 6.96298980531773e-11 NA NA NA hsa-miR-374b-5p ADAM12 -0.210113949579608 0.0056866083818614 1.04394410405498 1.19114934803854e-12 mirMAP -0.320102661939534 0.0011393070677349 NA NA NA hsa-miR-491-5p ADAM12 -0.749881113074983 8.22859263179194e-09 1.04394410405498 1.19114934803854e-12 miRanda -0.221463371324742 7.22249786933004e-06 NA NA NA hsa-miR-767-5p ADAM12 -0.551653504513145 2.61109058244854e-05 1.04394410405498 1.19114934803854e-12 PITA;miRNATAP -0.376700308496885 3.77007612623163e-14 NA NA NA hsa-miR-200b-3p BASP1 0.245768526504511 0.0580744465744737 -0.486211739382857 6.48040257284722e-07 TargetScan -0.152799215827582 9.48187191497622e-07 NA NA NA hsa-miR-200c-3p BASP1 0.413752622631695 8.6936333715621e-06 -0.486211739382857 6.48040257284722e-07 miRNATAP -0.208061668475365 9.89599510928992e-07 NA NA NA hsa-miR-21-5p BASP1 1.0504925175311 2.58081295984106e-11 -0.486211739382857 6.48040257284722e-07 miRNAWalker2_validate;miRTarBase -0.27569976304215 5.12523309872382e-24 NA NA NA hsa-miR-320a BASP1 0.092135599636725 0.243028758989929 -0.486211739382857 6.48040257284722e-07 PITA;miRanda -0.324463275786303 2.46632452126076e-07 NA NA NA hsa-miR-320b BASP1 0.283477746304177 0.0005953763020907 -0.486211739382857 6.48040257284722e-07 PITA;miRanda -0.25759171727453 7.20891028880068e-08 NA NA NA hsa-miR-320c BASP1 0.343259124189966 0.000248338401291051 -0.486211739382857 6.48040257284722e-07 PITA;miRanda -0.312172001227049 3.38371380263354e-13 NA NA NA hsa-miR-590-3p BASP1 0.312951515438396 0.000480455423843996 -0.486211739382857 6.48040257284722e-07 miRanda -0.232546130090091 1.38204502660233e-07 NA NA NA hsa-miR-629-3p BASP1 0.318874955109265 0.00062631284800046 -0.486211739382857 6.48040257284722e-07 miRNATAP -0.123010952649839 0.00417413617132974 NA NA NA hsa-miR-3065-3p BDNF -0.261348288537884 0.0343753235107924 0.163817385359977 0.296772674802745 MirTarget;miRNATAP -0.263514713378115 5.47125066901657e-06 NA NA NA hsa-miR-3065-5p BDNF -0.262608140481507 0.0414570974148034 0.163817385359977 0.296772674802745 mirMAP;miRNATAP -0.276290459467715 1.96100180067284e-07 NA NA NA hsa-miR-326 BGN -0.631050656251074 8.83643450601471e-05 0.839326478716147 4.05838003926357e-14 miRanda -0.145705763386158 4.65865358800113e-07 NA NA NA hsa-miR-125a-5p BMP1 -0.0833349424517387 0.325440200253607 0.297830750099227 3.28896004200852e-07 mirMAP -0.163071792081092 1.62996113441023e-06 NA NA NA hsa-miR-125b-5p BMP1 -0.0119698382910496 0.890233923197358 0.297830750099227 3.28896004200852e-07 mirMAP -0.107040143111011 0.00925359652466814 NA NA NA hsa-miR-139-3p BMP1 -0.697844024219975 4.41573169040691e-06 0.297830750099227 3.28896004200852e-07 miRNATAP -0.14994820810098 5.96120756045041e-24 NA NA NA hsa-miR-139-5p BMP1 -0.647754756897633 2.15378307237163e-06 0.297830750099227 3.28896004200852e-07 miRanda -0.201852378655831 4.34992693720797e-34 NA NA NA hsa-miR-29a-3p BMP1 -0.224140851576083 0.0349516103550236 0.297830750099227 3.28896004200852e-07 miRNATAP -0.212914434514641 4.83100149585558e-14 NA NA NA hsa-miR-29b-3p BMP1 -0.178522712044497 0.0856106432165465 0.297830750099227 3.28896004200852e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.215676251259133 1.59824261692691e-18 NA NA NA hsa-miR-29c-3p BMP1 -0.372180390387259 0.00202634431973208 0.297830750099227 3.28896004200852e-07 miRNATAP -0.192409465999719 1.25402766066793e-20 NA NA NA hsa-miR-491-5p BMP1 -0.749881113074983 8.22859263179194e-09 0.297830750099227 3.28896004200852e-07 PITA;miRanda -0.203005691342059 1.63081529269423e-34 NA NA NA hsa-miR-3065-5p CADM1 -0.262608140481507 0.0414570974148034 -0.130137323274293 0.0518125793967096 mirMAP;miRNATAP -0.122878134987506 7.9030385746001e-11 NA NA NA hsa-miR-505-3p CADM1 0.115486008167472 0.109833720698312 -0.130137323274293 0.0518125793967096 MirTarget -0.104502537955595 0.00380588203888847 NA NA NA hsa-miR-129-5p CALD1 -0.567133990117126 0.00116152215679936 0.385744127416854 8.9399532603343e-08 miRanda -0.108759213319541 1.21732953309098e-11 NA NA NA hsa-miR-137 CALD1 -0.924849266740909 1.546832202049e-06 0.385744127416854 8.9399532603343e-08 miRanda -0.122876173824975 7.56326191300958e-19 NA NA NA hsa-miR-139-5p CALD1 -0.647754756897633 2.15378307237163e-06 0.385744127416854 8.9399532603343e-08 miRanda -0.199918112805853 3.89116590336544e-23 NA NA NA hsa-miR-338-3p CALD1 -0.39963704679384 0.0034410643220691 0.385744127416854 8.9399532603343e-08 miRanda -0.15510125855943 1.85408617236225e-12 NA NA NA hsa-miR-338-5p CALD1 -0.424003687569629 0.00246415720301323 0.385744127416854 8.9399532603343e-08 PITA;miRNATAP -0.103939315285829 1.94167053605968e-07 NA NA NA hsa-miR-490-3p CALD1 -0.834268051506884 5.26203010743215e-06 0.385744127416854 8.9399532603343e-08 miRanda -0.120914328689842 6.13267964411697e-16 NA NA NA hsa-miR-491-5p CALD1 -0.749881113074983 8.22859263179194e-09 0.385744127416854 8.9399532603343e-08 miRanda -0.133657109435857 1.11596211823988e-10 NA NA NA hsa-miR-181a-5p CALU -0.178215604431845 0.0700010802255601 0.462374378558756 8.71003298797398e-12 mirMAP -0.109605846082326 0.00254604514011704 NA NA NA hsa-miR-30b-5p CALU -0.0858101016322106 0.263243418521854 0.462374378558756 8.71003298797398e-12 MirTarget -0.175685762199923 1.67299770856948e-05 NA NA NA hsa-miR-9-5p CALU -0.125377971246422 0.269896477802284 0.462374378558756 8.71003298797398e-12 mirMAP -0.558368672664112 1.76645369894882e-24 NA NA NA hsa-miR-320a CAP2 0.092135599636725 0.243028758989929 -0.0130652696017917 0.917741991757507 miRanda -0.290994450876009 0.0007800948450581 NA NA NA hsa-miR-139-5p CAPG -0.647754756897633 2.15378307237163e-06 0.506439658164211 3.79086634892054e-05 miRanda -0.227282539946509 1.14939234930176e-08 NA NA NA hsa-miR-346 CAPG -0.577786425963268 2.10883270131593e-09 0.506439658164211 3.79086634892054e-05 miRanda -0.177414204246643 0.00124818216838049 NA NA NA hsa-miR-137 CD44 -0.924849266740909 1.546832202049e-06 0.454265310281508 0.00121510157685034 miRanda -0.220879448048906 1.06611204556456e-13 NA NA NA hsa-miR-138-5p CD44 -0.616087649920851 1.35200027885729e-05 0.454265310281508 0.00121510157685034 MirTarget -0.363787988084945 3.0607119194613e-19 NA NA NA hsa-miR-326 CD44 -0.631050656251074 8.83643450601471e-05 0.454265310281508 0.00121510157685034 miRanda -0.115233431787251 0.00156780722286918 NA NA NA hsa-miR-328-3p CD44 -0.27021372890849 0.00243992234645524 0.454265310281508 0.00121510157685034 miRNAWalker2_validate;miRTarBase -0.20643884135489 0.00548378669820113 NA NA NA hsa-miR-488-3p CD44 -0.257955761012568 0.00280795162806256 0.454265310281508 0.00121510157685034 mirMAP -0.201867714315846 0.00404881486799591 NA NA NA hsa-miR-744-5p CD44 -0.31868579180387 0.000969037378618306 0.454265310281508 0.00121510157685034 miRNAWalker2_validate -0.204478568079579 0.00156067105023615 NA NA NA hsa-miR-92a-3p CD59 0.0407239381334659 0.643983393805961 -0.10586331598725 0.0987095496910142 miRNAWalker2_validate -0.119675497017045 0.00131214565671332 NA NA NA hsa-miR-124-5p CDH11 -0.675122821846076 2.29104160508523e-06 0.312004352619478 8.34060604536652e-06 mirMAP -0.14367368645979 6.69714533235329e-15 NA NA NA hsa-miR-137 CDH11 -0.924849266740909 1.546832202049e-06 0.312004352619478 8.34060604536652e-06 miRanda;mirMAP -0.130423935658051 1.75252855924625e-22 NA NA NA hsa-miR-139-5p CDH11 -0.647754756897633 2.15378307237163e-06 0.312004352619478 8.34060604536652e-06 miRanda -0.157661284023747 2.69518002099809e-15 NA NA NA hsa-miR-7-1-3p CDH11 -0.0894475316162393 0.37322359785108 0.312004352619478 8.34060604536652e-06 mirMAP -0.11062365142609 4.67671590404538e-05 NA NA NA hsa-miR-105-5p CDH2 -0.567459149851677 8.20858944634795e-06 0.122121996525445 0.0332657505033006 MirTarget;miRNATAP -0.111311261406491 3.29521678006376e-14 NA NA NA hsa-miR-20a-3p CDH6 0.102743778777997 0.19677865359751 0.280085569872042 0.000973336286308804 mirMAP -0.152698241554789 0.00104670158490565 NA NA NA hsa-miR-374b-5p CDH6 -0.210113949579608 0.0056866083818614 0.280085569872042 0.000973336286308804 mirMAP -0.167074582515831 0.00225577984271234 NA NA NA hsa-miR-767-5p CDH6 -0.551653504513145 2.61109058244854e-05 0.280085569872042 0.000973336286308804 MirTarget -0.225092416772236 2.94907591768815e-16 NA NA NA hsa-miR-137 COL11A1 -0.924849266740909 1.546832202049e-06 0.328757863112027 0.146624061178047 PITA;miRanda -0.165018754419579 0.00108499718117532 NA NA NA hsa-miR-9-5p COL12A1 -0.125377971246422 0.269896477802284 0.364709844749789 0.00463372769284584 miRNAWalker2_validate;miRNATAP -1.08573267822529 1.46816230982297e-19 NA NA NA hsa-miR-3065-3p COL16A1 -0.261348288537884 0.0343753235107924 0.106246456751822 0.318538283416877 MirTarget;miRNATAP -0.110083908710627 0.00356482833766515 NA NA NA hsa-miR-3065-5p COL16A1 -0.262608140481507 0.0414570974148034 0.106246456751822 0.318538283416877 MirTarget -0.213743371390185 4.15398529487869e-10 NA NA NA hsa-miR-124-3p COL1A1 -0.506026514549291 0.0078056370358648 1.23998298011727 1.14065510873293e-09 miRNAWalker2_validate;mirMAP -0.274473693173072 5.35141345558867e-09 NA NA NA hsa-miR-129-2-3p COL1A1 -0.6175132197013 0.000561573620904867 1.23998298011727 1.14065510873293e-09 mirMAP -0.346072907997388 2.12119777773723e-12 NA NA NA hsa-miR-129-5p COL1A1 -0.567133990117126 0.00116152215679936 1.23998298011727 1.14065510873293e-09 miRanda -0.377496478237911 2.64782833300606e-13 NA NA NA hsa-miR-133a-3p COL1A1 -0.335058908302964 0.0180402783121034 1.23998298011727 1.14065510873293e-09 miRNAWalker2_validate -0.164355503397801 0.00949277474051173 NA NA NA hsa-miR-218-5p COL1A1 -0.534287404275829 0.00308322441944796 1.23998298011727 1.14065510873293e-09 MirTarget;miRNATAP -0.196467261308336 6.9700759686819e-05 NA NA NA hsa-miR-29a-3p COL1A1 -0.224140851576083 0.0349516103550236 1.23998298011727 1.14065510873293e-09 miRNATAP -0.371642854777004 0.000801619915147498 NA NA NA hsa-miR-29c-3p COL1A1 -0.372180390387259 0.00202634431973208 1.23998298011727 1.14065510873293e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.326657793697716 6.84727320501142e-05 NA NA NA hsa-miR-330-3p COL1A1 -0.427388106938151 0.00300489284414266 1.23998298011727 1.14065510873293e-09 mirMAP -0.294327210693087 1.96552274542298e-06 NA NA NA hsa-miR-338-3p COL1A1 -0.39963704679384 0.0034410643220691 1.23998298011727 1.14065510873293e-09 miRanda;miRNATAP -0.450502875303921 2.83790953897927e-10 NA NA NA hsa-miR-577 COL1A1 -0.382068371859275 0.0145513192729119 1.23998298011727 1.14065510873293e-09 MirTarget;PITA;miRNATAP -0.241453460391243 3.09144442047382e-05 NA NA NA hsa-miR-935 COL1A1 -0.277848050075718 0.02166231531395 1.23998298011727 1.14065510873293e-09 PITA -0.394772293015598 1.67232518586797e-07 NA NA NA hsa-miR-129-5p COL1A2 -0.567133990117126 0.00116152215679936 0.945719713706391 9.33034616922201e-13 miRanda -0.180359652485836 8.27568981417803e-08 NA NA NA hsa-miR-29c-3p COL1A2 -0.372180390387259 0.00202634431973208 0.945719713706391 9.33034616922201e-13 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158253676789885 0.00283427452288408 NA NA NA hsa-miR-330-5p COL1A2 -0.262932095995605 0.0465226565966658 0.945719713706391 9.33034616922201e-13 miRanda -0.125110383739967 0.00451257429123947 NA NA NA hsa-miR-490-3p COL1A2 -0.834268051506884 5.26203010743215e-06 0.945719713706391 9.33034616922201e-13 miRanda -0.195400455357079 5.48117127882046e-10 NA NA NA hsa-miR-767-5p COL1A2 -0.551653504513145 2.61109058244854e-05 0.945719713706391 9.33034616922201e-13 PITA;miRNATAP -0.235415237340486 1.22979399258405e-07 NA NA NA hsa-miR-128-3p COL3A1 -0.781932174412672 7.1812756321342e-10 1.43331954235498 3.86186762290613e-13 MirTarget -0.702024384900442 3.39671131569039e-22 NA NA NA hsa-miR-129-5p COL3A1 -0.567133990117126 0.00116152215679936 1.43331954235498 3.86186762290613e-13 miRanda -0.383488213291544 2.46561381295259e-14 NA NA NA hsa-miR-219a-2-3p COL3A1 -0.57031561517274 0.000116587877956463 1.43331954235498 3.86186762290613e-13 MirTarget -0.573863469125513 1.53934130768328e-20 NA NA NA hsa-miR-29a-3p COL3A1 -0.224140851576083 0.0349516103550236 1.43331954235498 3.86186762290613e-13 MirTarget;miRNATAP -0.514486249317985 1.75924850156374e-06 NA NA NA hsa-miR-29b-3p COL3A1 -0.178522712044497 0.0856106432165465 1.43331954235498 3.86186762290613e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.441692040144896 2.96263104275717e-06 NA NA NA hsa-miR-29c-3p COL3A1 -0.372180390387259 0.00202634431973208 1.43331954235498 3.86186762290613e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.471492847843104 2.84296311192141e-09 NA NA NA hsa-miR-326 COL3A1 -0.631050656251074 8.83643450601471e-05 1.43331954235498 3.86186762290613e-13 miRanda -0.326665261085634 1.00674725462259e-09 NA NA NA hsa-miR-330-5p COL3A1 -0.262932095995605 0.0465226565966658 1.43331954235498 3.86186762290613e-13 miRanda -0.328423670017465 7.18994943888574e-07 NA NA NA hsa-miR-380-5p COL3A1 -0.356387125389103 0.0163515117264043 1.43331954235498 3.86186762290613e-13 MirTarget;miRNATAP -0.169138064892082 0.00546520206052042 NA NA NA hsa-miR-410-3p COL3A1 -0.377141009739972 0.0352223530182182 1.43331954235498 3.86186762290613e-13 MirTarget -0.191704198622117 9.74702431209673e-05 NA NA NA hsa-miR-767-5p COL3A1 -0.551653504513145 2.61109058244854e-05 1.43331954235498 3.86186762290613e-13 MirTarget;PITA;miRNATAP -0.255485416508271 0.000168949654906284 NA NA NA hsa-miR-124-3p COL4A1 -0.506026514549291 0.0078056370358648 1.37431841954319 3.47482076750947e-19 miRNAWalker2_validate;miRNATAP -0.220143731041708 7.51852180978931e-10 NA NA NA hsa-miR-129-5p COL4A1 -0.567133990117126 0.00116152215679936 1.37431841954319 3.47482076750947e-19 miRanda -0.32153127115203 1.89727248428967e-16 NA NA NA hsa-miR-137 COL4A1 -0.924849266740909 1.546832202049e-06 1.37431841954319 3.47482076750947e-19 miRanda -0.320596630925449 3.40808309589293e-21 NA NA NA hsa-miR-218-5p COL4A1 -0.534287404275829 0.00308322441944796 1.37431841954319 3.47482076750947e-19 miRNAWalker2_validate -0.205445314697783 3.87694837471037e-08 NA NA NA hsa-miR-29a-3p COL4A1 -0.224140851576083 0.0349516103550236 1.37431841954319 3.47482076750947e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.380157767698226 6.16882636437929e-06 NA NA NA hsa-miR-29b-3p COL4A1 -0.178522712044497 0.0856106432165465 1.37431841954319 3.47482076750947e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.351360819517442 1.87672188936429e-06 NA NA NA hsa-miR-29c-3p COL4A1 -0.372180390387259 0.00202634431973208 1.37431841954319 3.47482076750947e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.338979855521423 4.78557133695897e-08 NA NA NA hsa-miR-3065-5p COL4A1 -0.262608140481507 0.0414570974148034 1.37431841954319 3.47482076750947e-19 miRNATAP -0.165314340392216 0.00201928760917277 NA NA NA hsa-miR-326 COL4A1 -0.631050656251074 8.83643450601471e-05 1.37431841954319 3.47482076750947e-19 miRanda -0.248166369489074 2.82762989851826e-09 NA NA NA hsa-miR-330-5p COL4A1 -0.262932095995605 0.0465226565966658 1.37431841954319 3.47482076750947e-19 miRanda -0.169099479618787 0.00115978611437664 NA NA NA hsa-miR-346 COL4A1 -0.577786425963268 2.10883270131593e-09 1.37431841954319 3.47482076750947e-19 miRanda -0.649569888242356 1.31729453599891e-21 NA NA NA hsa-miR-490-3p COL4A1 -0.834268051506884 5.26203010743215e-06 1.37431841954319 3.47482076750947e-19 miRanda;miRNATAP -0.318273917640076 3.52952597375553e-18 NA NA NA hsa-miR-543 COL4A1 -0.347737549779625 0.0157394585079683 1.37431841954319 3.47482076750947e-19 miRanda -0.154824393055625 0.00148934658101073 NA NA NA hsa-miR-628-5p COL4A1 -0.0469793532265896 0.657420003383685 1.37431841954319 3.47482076750947e-19 PITA;miRNATAP -0.199016143250972 0.00269857696715821 NA NA NA hsa-miR-767-5p COL4A1 -0.551653504513145 2.61109058244854e-05 1.37431841954319 3.47482076750947e-19 PITA;miRNATAP -0.265584551412774 4.71075133790993e-07 NA NA NA hsa-miR-769-3p COL4A1 -0.287263649023213 0.018145224330845 1.37431841954319 3.47482076750947e-19 miRNAWalker2_validate -0.208662411186863 0.000214614363506648 NA NA NA hsa-miR-99a-5p COL4A1 -0.120081919053582 0.258277048014275 1.37431841954319 3.47482076750947e-19 miRNAWalker2_validate -0.289991147108519 0.000384081578368666 NA NA NA hsa-miR-29a-3p COL4A2 -0.224140851576083 0.0349516103550236 1.20726274584922 7.43650937307398e-19 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.281339814035671 0.000148706268297105 NA NA NA hsa-miR-29b-3p COL4A2 -0.178522712044497 0.0856106432165465 1.20726274584922 7.43650937307398e-19 miRTarBase;MirTarget;miRNATAP -0.242498314795871 0.000195424997065481 NA NA NA hsa-miR-29c-3p COL4A2 -0.372180390387259 0.00202634431973208 1.20726274584922 7.43650937307398e-19 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.254241114757276 3.52611448605167e-06 NA NA NA hsa-miR-9-5p COL4A2 -0.125377971246422 0.269896477802284 1.20726274584922 7.43650937307398e-19 MirTarget;miRNATAP -1.11063677871337 6.21799721119648e-18 NA NA NA hsa-miR-135a-5p COL5A1 -0.122734612943241 0.196985964641886 1.1630587399442 5.94137616866085e-12 miRNATAP -0.33318749856293 4.90348838357834e-05 NA NA NA hsa-miR-137 COL5A1 -0.924849266740909 1.546832202049e-06 1.1630587399442 5.94137616866085e-12 miRanda;miRNATAP -0.116970060584573 0.00253899768755479 NA NA NA hsa-miR-338-5p COL5A1 -0.424003687569629 0.00246415720301323 1.1630587399442 5.94137616866085e-12 miRNATAP -0.143479722818249 0.00854153976588641 NA NA NA hsa-miR-9-5p COL5A1 -0.125377971246422 0.269896477802284 1.1630587399442 5.94137616866085e-12 miRNATAP -1.78268603398568 6.88487688893123e-30 NA NA NA hsa-miR-92b-3p COL5A1 -0.213968504161963 0.0523921855715716 1.1630587399442 5.94137616866085e-12 miRNATAP -0.230234207150361 0.00395762024014382 NA NA NA hsa-miR-105-5p COL5A2 -0.567459149851677 8.20858944634795e-06 0.918256949383981 4.62260414598353e-13 MirTarget -0.276654972720279 3.67222086395046e-10 NA NA NA hsa-miR-181a-2-3p COL5A2 -0.0630409614874416 0.473088318215936 0.918256949383981 4.62260414598353e-13 MirTarget -0.352634510365849 8.52170475671422e-05 NA NA NA hsa-miR-3065-5p COL5A2 -0.262608140481507 0.0414570974148034 0.918256949383981 4.62260414598353e-13 MirTarget;mirMAP -0.245042979056567 1.39247069438858e-08 NA NA NA hsa-miR-338-5p COL5A2 -0.424003687569629 0.00246415720301323 0.918256949383981 4.62260414598353e-13 mirMAP -0.145158828250565 0.000318300961151812 NA NA NA hsa-miR-767-5p COL5A2 -0.551653504513145 2.61109058244854e-05 0.918256949383981 4.62260414598353e-13 MirTarget;PITA;miRNATAP -0.269522886528657 2.71425159175516e-10 NA NA NA hsa-miR-767-5p COL5A3 -0.551653504513145 2.61109058244854e-05 0.178146732086838 0.0802830821826829 MirTarget;PITA;miRNATAP -0.209567946811587 2.33969908141679e-10 NA NA NA hsa-miR-124-3p COL6A2 -0.506026514549291 0.0078056370358648 1.02041936795331 5.13715520230763e-14 miRNAWalker2_validate -0.10514655378741 0.000945145918679589 NA NA NA hsa-miR-129-2-3p COL6A2 -0.6175132197013 0.000561573620904867 1.02041936795331 5.13715520230763e-14 mirMAP -0.142848376691268 1.92595482485689e-05 NA NA NA hsa-miR-184 COL6A2 -0.842534984406592 6.08844932016991e-08 1.02041936795331 5.13715520230763e-14 miRanda -0.139619509943841 0.000279767195163777 NA NA NA hsa-miR-767-5p COL6A3 -0.551653504513145 2.61109058244854e-05 0.780087787207954 4.19040195033263e-06 MirTarget;PITA;miRNATAP -0.184680870356605 0.00139658137829875 NA NA NA hsa-miR-29b-3p COL7A1 -0.178522712044497 0.0856106432165465 -0.0119552123997915 0.933387720013581 MirTarget;miRNATAP -0.264524781110266 7.44113232227426e-05 NA NA NA hsa-miR-29c-3p COL7A1 -0.372180390387259 0.00202634431973208 -0.0119552123997915 0.933387720013581 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.19686090891652 0.000496542182272546 NA NA NA hsa-miR-361-3p COL7A1 -0.0798653643614555 0.271064714084553 -0.0119552123997915 0.933387720013581 miRNATAP -0.36791012561593 0.00017274972070112 NA NA NA hsa-miR-574-3p COL7A1 0.254057161073935 0.0219522676746007 -0.0119552123997915 0.933387720013581 miRNATAP -0.159345622756988 0.0047072947242611 NA NA NA hsa-miR-124-3p COL8A2 -0.506026514549291 0.0078056370358648 0.278510113564822 0.0333728682584516 miRNAWalker2_validate -0.129115458492064 1.67998362134369e-05 NA NA NA hsa-miR-20a-5p COL8A2 -0.0115865752288853 0.887069448776018 0.278510113564822 0.0333728682584516 mirMAP -0.389357684474726 3.38035328944445e-06 NA NA NA hsa-miR-582-5p COL8A2 -0.215764335500665 0.0760892640434509 0.278510113564822 0.0333728682584516 PITA -0.253572655929223 3.9830171765472e-08 NA NA NA hsa-miR-592 COL8A2 0.0170005651576508 0.876633091134809 0.278510113564822 0.0333728682584516 MirTarget;PITA;miRNATAP -0.507802828284698 3.60263898897119e-24 NA NA NA hsa-miR-124-3p CTGF -0.506026514549291 0.0078056370358648 0.270989425553384 0.0175308926378323 miRNAWalker2_validate;miRTarBase -0.127422688203196 2.64627110546144e-07 NA NA NA hsa-miR-132-3p CTGF -0.178379362833856 0.13335200877129 0.270989425553384 0.0175308926378323 MirTarget -0.140786834563509 0.000837995635402987 NA NA NA hsa-miR-411-3p CTGF -0.239070412422696 0.0940658517658304 0.270989425553384 0.0175308926378323 MirTarget;miRNATAP -0.106189888352358 0.00161368976986874 NA NA NA hsa-miR-543 CTGF -0.347737549779625 0.0157394585079683 0.270989425553384 0.0175308926378323 PITA;miRanda -0.127710623060904 0.000136469109266485 NA NA NA hsa-miR-9-5p CTHRC1 -0.125377971246422 0.269896477802284 0.822080933854249 1.31138440632824e-09 MirTarget;miRNATAP -1.24388914992414 1.44412387929494e-22 NA NA NA hsa-miR-320a CXCL12 0.092135599636725 0.243028758989929 0.0800878508583303 0.352608852363819 miRanda -0.159591410327508 0.00559354597781954 NA NA NA hsa-miR-129-5p DAB2 -0.567133990117126 0.00116152215679936 0.134743516972476 0.101745647630318 MirTarget;miRanda -0.158573130422734 8.14530696405388e-17 NA NA NA hsa-miR-134-5p DAB2 0.0228681180463912 0.875465441075562 0.134743516972476 0.101745647630318 MirTarget -0.114710084560377 9.67023011142369e-07 NA NA NA hsa-miR-139-5p DAB2 -0.647754756897633 2.15378307237163e-06 0.134743516972476 0.101745647630318 miRanda -0.245735210265129 2.53226135614985e-24 NA NA NA hsa-miR-149-5p DAB2 -0.0535821592029952 0.657713892012548 0.134743516972476 0.101745647630318 miRNATAP -0.191529959353532 5.81568646832046e-12 NA NA NA hsa-miR-203a-3p DAB2 -0.393041310603753 0.0191851699904077 0.134743516972476 0.101745647630318 MirTarget -0.189264379079621 3.455415530655e-23 NA NA NA hsa-miR-330-5p DAB2 -0.262932095995605 0.0465226565966658 0.134743516972476 0.101745647630318 miRanda -0.100014687883312 7.81493678062747e-05 NA NA NA hsa-miR-369-3p DAB2 -0.153496605399658 0.296055925448078 0.134743516972476 0.101745647630318 PITA -0.115987658195755 3.23798038676433e-07 NA NA NA hsa-miR-376a-5p DAB2 -0.0877544252790136 0.551096721204598 0.134743516972476 0.101745647630318 MirTarget -0.131904130914382 9.27022329593073e-09 NA NA NA hsa-miR-488-3p DAB2 -0.257955761012568 0.00280795162806256 0.134743516972476 0.101745647630318 MirTarget -0.139908438799487 0.000416670238209853 NA NA NA hsa-miR-539-5p DAB2 -0.326485413953598 0.0554453076411246 0.134743516972476 0.101745647630318 MirTarget -0.16684524306935 1.38352826538189e-18 NA NA NA hsa-miR-935 DAB2 -0.277848050075718 0.02166231531395 0.134743516972476 0.101745647630318 PITA;miRNATAP -0.232069574150342 2.82684604070333e-17 NA NA NA hsa-let-7c-5p DCN -0.04295851886768 0.676052842748691 0.274695090993536 0.00406434743874428 MirTarget -0.166810772884901 0.00183871004765718 NA NA NA hsa-miR-3065-5p DCN -0.262608140481507 0.0414570974148034 0.274695090993536 0.00406434743874428 mirMAP -0.148533073258969 1.44789386339781e-06 NA NA NA hsa-miR-107 DPYSL3 -0.121070851008387 0.198381281894242 -0.0976827098967874 0.229803497266161 miRanda -0.23493684524189 2.00844106104616e-16 NA NA NA hsa-miR-125a-5p DPYSL3 -0.0833349424517387 0.325440200253607 -0.0976827098967874 0.229803497266161 miRanda -0.336467526477927 4.40353426730906e-20 NA NA NA hsa-miR-1266-5p DPYSL3 0.313515127917259 0.0138664194727392 -0.0976827098967874 0.229803497266161 MirTarget -0.150005832868385 9.24780566779844e-14 NA NA NA hsa-miR-132-3p DPYSL3 -0.178379362833856 0.13335200877129 -0.0976827098967874 0.229803497266161 MirTarget;miRNATAP -0.188045142783612 8.38503363759387e-17 NA NA NA hsa-miR-137 DPYSL3 -0.924849266740909 1.546832202049e-06 -0.0976827098967874 0.229803497266161 miRanda -0.1010454129818 9.24899720595867e-15 NA NA NA hsa-miR-141-3p DPYSL3 0.41120561991992 0.000393344390969055 -0.0976827098967874 0.229803497266161 TargetScan -0.113368084350845 5.72698061474762e-07 NA NA NA hsa-miR-143-3p DPYSL3 0.289829963197683 0.0420892105534401 -0.0976827098967874 0.229803497266161 MirTarget -0.112084169104529 4.60416031920845e-08 NA NA NA hsa-miR-150-5p DPYSL3 0.0645271721519611 0.513295658828718 -0.0976827098967874 0.229803497266161 mirMAP -0.152114009169274 2.15579870100904e-08 NA NA NA hsa-miR-197-3p DPYSL3 -0.176796295244328 0.0837698554789217 -0.0976827098967874 0.229803497266161 miRNAWalker2_validate -0.173181558248182 1.56733261981401e-09 NA NA NA hsa-miR-212-3p DPYSL3 -0.014112941209349 0.918360379512974 -0.0976827098967874 0.229803497266161 MirTarget;miRNATAP -0.139774829497568 4.27207048544006e-14 NA NA NA hsa-miR-22-3p DPYSL3 0.0277287593466351 0.809325106832648 -0.0976827098967874 0.229803497266161 miRNATAP -0.235926410875971 1.6067937808482e-14 NA NA NA hsa-miR-2355-5p DPYSL3 0.00808596988211185 0.916165501155096 -0.0976827098967874 0.229803497266161 MirTarget -0.228024256257389 9.31962886636507e-11 NA NA NA hsa-miR-26a-2-3p DPYSL3 0.26597501648608 0.000796444054340143 -0.0976827098967874 0.229803497266161 mirMAP -0.14756468106914 6.46281740636335e-06 NA NA NA hsa-miR-26b-5p DPYSL3 -0.0984536538762768 0.231803769574623 -0.0976827098967874 0.229803497266161 miRNAWalker2_validate -0.148952288479366 8.2788404362665e-05 NA NA NA hsa-miR-299-5p DPYSL3 -0.0814737109317336 0.57620244226785 -0.0976827098967874 0.229803497266161 PITA;miRNATAP -0.147081196012039 6.27037189996495e-17 NA NA NA hsa-miR-29a-3p DPYSL3 -0.224140851576083 0.0349516103550236 -0.0976827098967874 0.229803497266161 MirTarget -0.159225994973624 5.58616856201545e-07 NA NA NA hsa-miR-29b-3p DPYSL3 -0.178522712044497 0.0856106432165465 -0.0976827098967874 0.229803497266161 MirTarget -0.257714552456067 1.74163464119058e-21 NA NA NA hsa-miR-29c-3p DPYSL3 -0.372180390387259 0.00202634431973208 -0.0976827098967874 0.229803497266161 MirTarget -0.170537347813452 2.37111746799903e-13 NA NA NA hsa-miR-324-3p DPYSL3 -0.0103367134443655 0.904494071318044 -0.0976827098967874 0.229803497266161 PITA -0.220977976562489 8.18571357035762e-13 NA NA NA hsa-miR-330-3p DPYSL3 -0.427388106938151 0.00300489284414266 -0.0976827098967874 0.229803497266161 MirTarget;PITA;miRNATAP -0.12963116451595 1.80879620225254e-13 NA NA NA hsa-miR-335-3p DPYSL3 0.34540584335595 0.00043848660222294 -0.0976827098967874 0.229803497266161 mirMAP -0.154478110166211 1.32717859389336e-08 NA NA NA hsa-miR-338-5p DPYSL3 -0.424003687569629 0.00246415720301323 -0.0976827098967874 0.229803497266161 PITA -0.100269062548903 7.12659926311019e-08 NA NA NA hsa-miR-375 DPYSL3 -0.0268401141324031 0.858358101444697 -0.0976827098967874 0.229803497266161 miRNAWalker2_validate -0.108127779504358 1.97471842629047e-10 NA NA NA hsa-miR-423-3p DPYSL3 0.192317829125882 0.00125622290742326 -0.0976827098967874 0.229803497266161 miRNAWalker2_validate -0.212560732014216 6.84554022697107e-05 NA NA NA hsa-miR-543 DPYSL3 -0.347737549779625 0.0157394585079683 -0.0976827098967874 0.229803497266161 mirMAP -0.152914928606532 1.54892755495714e-17 NA NA NA hsa-miR-590-3p DPYSL3 0.312951515438396 0.000480455423843996 -0.0976827098967874 0.229803497266161 miRanda;mirMAP -0.15773254002907 4.2312014777163e-08 NA NA NA hsa-let-7i-5p DST 0.0952853587923244 0.192120688957249 -0.191810307666026 0.0128722468156541 miRNATAP -0.158255912804684 0.00029181354381249 NA NA NA hsa-miR-106a-5p DST 0.110074064773897 0.13045815990621 -0.191810307666026 0.0128722468156541 mirMAP -0.224490003151761 4.66276289216534e-10 NA NA NA hsa-miR-125a-5p DST -0.0833349424517387 0.325440200253607 -0.191810307666026 0.0128722468156541 mirMAP -0.136893951254144 0.000172768986434304 NA NA NA hsa-miR-141-3p DST 0.41120561991992 0.000393344390969055 -0.191810307666026 0.0128722468156541 mirMAP -0.105926606953489 1.21316415189667e-06 NA NA NA hsa-miR-146b-5p DST 0.441078059667297 0.000237619929889385 -0.191810307666026 0.0128722468156541 miRanda -0.175035675585468 1.95118720145154e-16 NA NA NA hsa-miR-149-5p DST -0.0535821592029952 0.657713892012548 -0.191810307666026 0.0128722468156541 mirMAP -0.113124306037572 7.07329976858386e-08 NA NA NA hsa-miR-15b-3p DST 0.690804403863844 8.48784755123775e-09 -0.191810307666026 0.0128722468156541 mirMAP -0.117079986974193 8.00296580769948e-09 NA NA NA hsa-miR-16-2-3p DST 0.468816222075619 7.04377763166292e-05 -0.191810307666026 0.0128722468156541 mirMAP -0.120164442784547 7.53397184153212e-09 NA NA NA hsa-miR-18a-5p DST 0.175320895022849 0.0732549187136286 -0.191810307666026 0.0128722468156541 mirMAP -0.108458418305906 2.01554870307767e-05 NA NA NA hsa-miR-199a-5p DST 0.174889610847968 0.0900027418912454 -0.191810307666026 0.0128722468156541 mirMAP -0.141210040680996 6.81239750505011e-09 NA NA NA hsa-miR-200c-3p DST 0.413752622631695 8.6936333715621e-06 -0.191810307666026 0.0128722468156541 mirMAP -0.137312936775362 2.59088394396025e-07 NA NA NA hsa-miR-20b-5p DST 0.144541062989476 0.0992042333556543 -0.191810307666026 0.0128722468156541 mirMAP -0.141854880466864 3.75344446673541e-06 NA NA NA hsa-miR-222-3p DST 0.107117065575197 0.423818119725697 -0.191810307666026 0.0128722468156541 mirMAP -0.104760006355657 1.36411687481475e-08 NA NA NA hsa-miR-25-3p DST 0.316649850160985 0.000777982468387578 -0.191810307666026 0.0128722468156541 mirMAP -0.153820793599457 9.03768148672354e-06 NA NA NA hsa-miR-29b-1-5p DST 0.191335428755774 0.00846436454790702 -0.191810307666026 0.0128722468156541 mirMAP -0.174928715801437 3.1633202415191e-07 NA NA NA hsa-miR-320a DST 0.092135599636725 0.243028758989929 -0.191810307666026 0.0128722468156541 mirMAP -0.112035088554539 0.00490496066121391 NA NA NA hsa-miR-335-3p DST 0.34540584335595 0.00043848660222294 -0.191810307666026 0.0128722468156541 mirMAP -0.112681476146729 1.86414848703933e-05 NA NA NA hsa-miR-335-5p DST 0.0938511632756978 0.336889056387694 -0.191810307666026 0.0128722468156541 miRNAWalker2_validate -0.119413261390887 4.52738121057465e-06 NA NA NA hsa-miR-362-5p DST -0.0730185557229279 0.425572997292224 -0.191810307666026 0.0128722468156541 TargetScan;mirMAP -0.169221336832308 7.69179200196108e-10 NA NA NA hsa-miR-363-3p DST -0.0500185604139096 0.527823314542991 -0.191810307666026 0.0128722468156541 mirMAP -0.160655127092278 1.7119663950899e-06 NA NA NA hsa-miR-500a-3p DST 0.0479457078972052 0.49420307623914 -0.191810307666026 0.0128722468156541 mirMAP -0.280965224719179 1.13516853020149e-11 NA NA NA hsa-miR-505-3p DST 0.115486008167472 0.109833720698312 -0.191810307666026 0.0128722468156541 mirMAP -0.132283496223205 0.000308336601057884 NA NA NA hsa-miR-592 DST 0.0170005651576508 0.876633091134809 -0.191810307666026 0.0128722468156541 mirMAP -0.111941737127712 9.07690229558414e-07 NA NA NA hsa-miR-664a-3p DST 0.0413918462467198 0.611334357897022 -0.191810307666026 0.0128722468156541 mirMAP -0.228204781438128 1.82195798412974e-13 NA NA NA hsa-miR-664a-5p DST 0.0825994937558296 0.264421724444089 -0.191810307666026 0.0128722468156541 mirMAP -0.16414982802194 1.19802345997728e-06 NA NA NA hsa-miR-93-5p DST 0.139766237971122 0.101057320076629 -0.191810307666026 0.0128722468156541 mirMAP -0.203307229480603 6.85646090961713e-06 NA NA NA hsa-miR-1296-5p ECM2 -0.54372484392435 2.8372994306455e-07 0.635051650376133 3.47500301233186e-06 MirTarget -0.386740493767057 7.839833823492e-12 NA NA NA hsa-miR-323a-3p ECM2 -0.391730191938842 0.0220003672777098 0.635051650376133 3.47500301233186e-06 MirTarget -0.119961736992995 0.000596995142061169 NA NA NA hsa-miR-346 ECM2 -0.577786425963268 2.10883270131593e-09 0.635051650376133 3.47500301233186e-06 miRanda -0.404655859536588 2.59127270773408e-11 NA NA NA hsa-miR-195-3p EDIL3 0.100105455903079 0.133362389112338 -0.618192885421041 6.79420434555256e-05 mirMAP -0.365517805357966 0.000525310333651585 NA NA NA hsa-miR-217 EDIL3 0.540279882451941 0.00312206944061206 -0.618192885421041 6.79420434555256e-05 PITA;miRanda -0.131142638876919 0.000414345764350408 NA NA NA hsa-miR-128-3p EFEMP2 -0.781932174412672 7.1812756321342e-10 0.47028148088148 7.0910849929485e-05 miRNAWalker2_validate -0.143958626380754 0.00100987783008482 NA NA NA hsa-miR-346 EFEMP2 -0.577786425963268 2.10883270131593e-09 0.47028148088148 7.0910849929485e-05 mir2Disease;miRNAWalker2_validate;miRTarBase -0.140679888103739 0.00760467274201264 NA NA NA hsa-miR-101-3p ELN -0.132333931567244 0.241891922291381 0.531275097125981 1.31485435936797e-08 miRNATAP -0.143770094661996 0.00167073412198216 NA NA NA hsa-miR-29a-3p ELN -0.224140851576083 0.0349516103550236 0.531275097125981 1.31485435936797e-08 MirTarget;miRNATAP -0.172919980666442 0.000402099518444301 NA NA NA hsa-miR-29b-3p ELN -0.178522712044497 0.0856106432165465 0.531275097125981 1.31485435936797e-08 MirTarget;miRNATAP -0.200776001405244 2.55735732667149e-06 NA NA NA hsa-miR-29c-3p ELN -0.372180390387259 0.00202634431973208 0.531275097125981 1.31485435936797e-08 MirTarget;miRNATAP -0.148527324358153 4.01284806290988e-05 NA NA NA hsa-miR-331-3p ELN 0.0126984726684189 0.905175053956974 0.531275097125981 1.31485435936797e-08 MirTarget;PITA -0.108482572214993 0.00417946466963959 NA NA NA hsa-miR-383-5p ELN -0.850440167826561 1.6745326125383e-07 0.531275097125981 1.31485435936797e-08 MirTarget -0.16104313283531 2.80062560113497e-11 NA NA NA hsa-miR-491-5p ELN -0.749881113074983 8.22859263179194e-09 0.531275097125981 1.31485435936797e-08 MirTarget;miRanda;miRNATAP -0.196742654138405 2.4551822116392e-11 NA NA NA hsa-miR-767-5p ELN -0.551653504513145 2.61109058244854e-05 0.531275097125981 1.31485435936797e-08 MirTarget;PITA;miRNATAP -0.14241273456716 3.18771779012375e-06 NA NA NA hsa-miR-892a FAP -0.242011750672218 0.136146245118012 0.254779886018846 0.108508432681707 PITA;miRNATAP -0.166752091329428 0.000147524953143503 NA NA NA hsa-miR-504-5p FAS -0.510726779625117 6.12122269907368e-05 0.265125211236005 0.00536978445115343 miRNAWalker2_validate -0.123587493507518 0.000186057016947978 NA NA NA hsa-let-7a-3p FBN1 0.0530563276543763 0.370749834463566 0.0722118387006132 0.350935867244868 mirMAP -0.18915719972023 0.00184898074065241 NA NA NA hsa-miR-101-3p FBN2 -0.132333931567244 0.241891922291381 0.103475736280628 0.513367314240293 miRNAWalker2_validate;MirTarget;miRNATAP -0.223528442602175 0.00475237734232396 NA NA NA hsa-miR-107 FBN2 -0.121070851008387 0.198381281894242 0.103475736280628 0.513367314240293 miRanda -0.454486783567987 2.9878227255908e-09 NA NA NA hsa-miR-125a-3p FBN2 0.183834985432376 0.106230647107917 0.103475736280628 0.513367314240293 miRanda -0.18896081828604 0.00201611111303676 NA NA NA hsa-miR-126-5p FBN2 0.177332403948664 0.0711675116243123 0.103475736280628 0.513367314240293 mirMAP -0.475407833715104 4.6950721646794e-11 NA NA NA hsa-miR-129-5p FBN2 -0.567133990117126 0.00116152215679936 0.103475736280628 0.513367314240293 miRanda -0.155404294832068 0.000106545894732019 NA NA NA hsa-miR-137 FBN2 -0.924849266740909 1.546832202049e-06 0.103475736280628 0.513367314240293 miRanda;miRNATAP -0.307406790095894 1.93031634279507e-19 NA NA NA hsa-miR-139-5p FBN2 -0.647754756897633 2.15378307237163e-06 0.103475736280628 0.513367314240293 MirTarget;PITA;miRanda;miRNATAP -0.319436033137024 4.05285950307136e-10 NA NA NA hsa-miR-140-3p FBN2 -0.123864258867705 0.14796686619449 0.103475736280628 0.513367314240293 PITA -0.512307687591073 1.2919589723528e-06 NA NA NA hsa-miR-140-5p FBN2 0.065063507103468 0.380452509211773 0.103475736280628 0.513367314240293 PITA;miRanda;miRNATAP -0.334201289208936 0.000912296457820697 NA NA NA hsa-miR-144-3p FBN2 0.185426471537742 0.329598425352088 0.103475736280628 0.513367314240293 MirTarget;miRNATAP -0.129942750665081 0.000365727256054978 NA NA NA hsa-miR-149-5p FBN2 -0.0535821592029952 0.657713892012548 0.103475736280628 0.513367314240293 miRNAWalker2_validate -0.379699583463289 3.2085400877645e-11 NA NA NA hsa-miR-204-5p FBN2 -0.288588537398065 0.113371226435822 0.103475736280628 0.513367314240293 MirTarget;miRNATAP -0.206810431078248 3.49797634613683e-08 NA NA NA hsa-miR-218-5p FBN2 -0.534287404275829 0.00308322441944796 0.103475736280628 0.513367314240293 MirTarget;miRNATAP -0.234176552466481 3.2641018955411e-10 NA NA NA hsa-miR-23b-3p FBN2 0.0476610245860094 0.630277683372344 0.103475736280628 0.513367314240293 MirTarget;miRNATAP -0.283761761959617 0.000264344019303767 NA NA NA hsa-miR-335-5p FBN2 0.0938511632756978 0.336889056387694 0.103475736280628 0.513367314240293 miRNAWalker2_validate -0.256225276335583 0.000356478643756382 NA NA NA hsa-miR-338-5p FBN2 -0.424003687569629 0.00246415720301323 0.103475736280628 0.513367314240293 mirMAP -0.225913907336427 4.65372309399857e-06 NA NA NA hsa-miR-342-3p FBN2 -0.125683829770877 0.105810751640137 0.103475736280628 0.513367314240293 miRanda -0.267097107426966 0.00730827896100778 NA NA NA hsa-miR-375 FBN2 -0.0268401141324031 0.858358101444697 0.103475736280628 0.513367314240293 miRanda -0.228877155870335 4.07656388856128e-07 NA NA NA hsa-miR-485-3p FBN2 -0.530677478972593 0.00148549219838911 0.103475736280628 0.513367314240293 MirTarget;PITA;miRNATAP -0.199622538127367 8.94404087878847e-07 NA NA NA hsa-miR-495-3p FBN2 -0.421982588962504 0.00504424038526901 0.103475736280628 0.513367314240293 MirTarget;mirMAP -0.238903924391374 1.42564097171713e-07 NA NA NA hsa-miR-496 FBN2 -0.139833482232877 0.39597541862532 0.103475736280628 0.513367314240293 miRanda -0.209414150968646 6.21369358449153e-07 NA NA NA hsa-miR-502-3p FBN2 0.0276791089364088 0.697605011368848 0.103475736280628 0.513367314240293 MirTarget;PITA -0.346603828233531 0.000417774252062877 NA NA NA hsa-miR-543 FBN2 -0.347737549779625 0.0157394585079683 0.103475736280628 0.513367314240293 MirTarget;PITA;miRanda -0.25088451632927 2.1809993989061e-07 NA NA NA hsa-miR-582-3p FBN2 -0.11807589183011 0.304077332003677 0.103475736280628 0.513367314240293 PITA;miRNATAP -0.447573230080048 9.37011619913336e-14 NA NA NA hsa-miR-625-3p FBN2 -0.0638840950852737 0.547354471747105 0.103475736280628 0.513367314240293 MirTarget -0.409778754051568 4.49724866085408e-10 NA NA NA hsa-miR-138-5p FERMT2 -0.616087649920851 1.35200027885729e-05 0.0012093796948518 0.984045000610288 MirTarget;miRNATAP -0.103729148712908 3.89151158074309e-13 NA NA NA hsa-miR-30b-5p FERMT2 -0.0858101016322106 0.263243418521854 0.0012093796948518 0.984045000610288 miRNAWalker2_validate -0.131260281431884 4.89353681735829e-05 NA NA NA hsa-let-7a-3p FGF2 0.0530563276543763 0.370749834463566 -0.310412510487203 1.0531264899139e-05 mirMAP -0.213352464353633 3.01948138253891e-05 NA NA NA hsa-let-7f-1-3p FGF2 0.110713086694053 0.21484524300518 -0.310412510487203 1.0531264899139e-05 mirMAP -0.103512481979716 0.000647773517119759 NA NA NA hsa-miR-103a-3p FGF2 -0.147443193527362 0.128400914654149 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.12655516361281 0.00679371182948832 NA NA NA hsa-miR-126-5p FGF2 0.177332403948664 0.0711675116243123 -0.310412510487203 1.0531264899139e-05 mirMAP -0.110162176340636 0.000136298645021207 NA NA NA hsa-miR-140-5p FGF2 0.065063507103468 0.380452509211773 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate -0.185361566298031 2.74319630927397e-06 NA NA NA hsa-miR-146a-5p FGF2 0.148942451196282 0.114229072828724 -0.310412510487203 1.0531264899139e-05 mirMAP -0.146277493567259 4.31070451040202e-07 NA NA NA hsa-miR-15a-5p FGF2 0.142658985373611 0.0536219185009004 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.207678236164206 2.5972218474549e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 0.690804403863844 8.48784755123775e-09 -0.310412510487203 1.0531264899139e-05 mirMAP -0.137724123749645 3.22216944518618e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.592863156692837 1.41971517354055e-10 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.259712883212368 3.66212966170394e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 0.468816222075619 7.04377763166292e-05 -0.310412510487203 1.0531264899139e-05 mirMAP -0.160896949653708 5.53366478735585e-13 NA NA NA hsa-miR-16-5p FGF2 0.246024668671282 0.00346042804503716 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.238035584676493 2.36870334343313e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 -0.178215604431845 0.0700010802255601 -0.310412510487203 1.0531264899139e-05 mirMAP -0.123717144171581 0.00107047935591826 NA NA NA hsa-miR-181b-5p FGF2 0.0260899284211646 0.768941836912518 -0.310412510487203 1.0531264899139e-05 mirMAP -0.215729610871528 1.18634456085395e-08 NA NA NA hsa-miR-19b-1-5p FGF2 0.0686579042235509 0.332645627997485 -0.310412510487203 1.0531264899139e-05 mirMAP -0.201459709129831 1.90976689008877e-07 NA NA NA hsa-miR-20a-3p FGF2 0.102743778777997 0.19677865359751 -0.310412510487203 1.0531264899139e-05 mirMAP -0.144973090746876 2.52878071686245e-05 NA NA NA hsa-miR-335-3p FGF2 0.34540584335595 0.00043848660222294 -0.310412510487203 1.0531264899139e-05 mirMAP -0.178439766262418 2.49255926048001e-10 NA NA NA hsa-miR-335-5p FGF2 0.0938511632756978 0.336889056387694 -0.310412510487203 1.0531264899139e-05 miRNATAP -0.140124965064104 6.34697534647765e-07 NA NA NA hsa-miR-361-5p FGF2 0.0107519600643302 0.882230614095565 -0.310412510487203 1.0531264899139e-05 mirMAP -0.181723993106071 8.88544014107461e-05 NA NA NA hsa-miR-376a-5p FGF2 -0.0877544252790136 0.551096721204598 -0.310412510487203 1.0531264899139e-05 mirMAP -0.113264250236629 1.03177567762586e-09 NA NA NA hsa-miR-376c-3p FGF2 -0.0513360810290662 0.710610589791979 -0.310412510487203 1.0531264899139e-05 mirMAP -0.132449788888867 7.98306703791068e-12 NA NA NA hsa-miR-424-5p FGF2 0.25140374049676 0.00709934939774983 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.137720507275413 5.34564200507529e-06 NA NA NA hsa-miR-450b-5p FGF2 0.270544879013992 0.00801537838499562 -0.310412510487203 1.0531264899139e-05 mirMAP -0.1181608495248 1.10414336833114e-05 NA NA NA hsa-miR-92a-3p FGF2 0.0407239381334659 0.643983393805961 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate -0.244288015297521 5.53502580269543e-07 NA NA NA hsa-miR-93-3p FGF2 0.0778767956494004 0.272224943247293 -0.310412510487203 1.0531264899139e-05 mirMAP -0.195143626431712 9.46174309952938e-07 NA NA NA hsa-miR-7-5p FLNA -0.244254069762734 0.193173919522103 0.482656529265684 3.91481585934668e-07 miRNAWalker2_validate -0.134957527393108 9.30943416873876e-12 NA NA NA hsa-miR-139-5p FN1 -0.647754756897633 2.15378307237163e-06 0.611643203379539 4.13939447374756e-09 miRanda -0.251483354032568 4.44995418646961e-16 NA NA NA hsa-miR-9-3p FN1 -0.184945845984695 0.0290051908009009 0.611643203379539 4.13939447374756e-09 MirTarget -0.423766015725708 2.33822633132945e-10 NA NA NA hsa-miR-101-5p FSTL1 -0.263105484860745 0.00306900408113868 0.710606398240091 7.27048278974265e-13 mirMAP -0.176070264741192 0.000300872968018792 NA NA NA hsa-miR-124-3p FSTL1 -0.506026514549291 0.0078056370358648 0.710606398240091 7.27048278974265e-13 miRNAWalker2_validate -0.102043601842593 4.35951172222318e-06 NA NA NA hsa-miR-139-5p FSTL1 -0.647754756897633 2.15378307237163e-06 0.710606398240091 7.27048278974265e-13 miRanda -0.264440112150552 1.30044383400336e-17 NA NA NA hsa-miR-181a-5p FSTL1 -0.178215604431845 0.0700010802255601 0.710606398240091 7.27048278974265e-13 mirMAP -0.239658807565565 4.68014866090807e-05 NA NA NA hsa-miR-203a-3p FSTL1 -0.393041310603753 0.0191851699904077 0.710606398240091 7.27048278974265e-13 MirTarget -0.10939841040406 1.23478211047505e-05 NA NA NA hsa-miR-346 FSTL1 -0.577786425963268 2.10883270131593e-09 0.710606398240091 7.27048278974265e-13 miRanda -0.353759027274698 6.493341064464e-17 NA NA NA hsa-miR-9-5p FSTL1 -0.125377971246422 0.269896477802284 0.710606398240091 7.27048278974265e-13 MirTarget -1.11872852937284 2.44628297252266e-38 NA NA NA hsa-miR-9-5p FSTL3 -0.125377971246422 0.269896477802284 0.21836511367461 0.00156002119589343 miRNAWalker2_validate -0.276993663451433 1.76163148959838e-05 NA NA NA hsa-miR-129-5p GADD45A -0.567133990117126 0.00116152215679936 0.578892696032557 1.73109905217762e-08 miRanda -0.117655587237976 4.85565235622386e-06 NA NA NA hsa-miR-504-5p GADD45A -0.510726779625117 6.12122269907368e-05 0.578892696032557 1.73109905217762e-08 miRNAWalker2_validate -0.168708037304693 1.35009592733874e-06 NA NA NA hsa-miR-767-3p GADD45B -0.429854368420513 0.000821445291167688 0.336709257563835 0.00421134915835084 miRNATAP -0.202993831911469 2.25161118087796e-07 NA NA NA hsa-miR-129-5p GAS1 -0.567133990117126 0.00116152215679936 0.711486782928409 6.58051594577455e-14 miRanda -0.112271904702611 3.14769094860931e-06 NA NA NA hsa-miR-374b-5p GAS1 -0.210113949579608 0.0056866083818614 0.711486782928409 6.58051594577455e-14 mirMAP -0.20343093915456 0.00101823253844157 NA NA NA hsa-miR-129-5p GEM -0.567133990117126 0.00116152215679936 0.590185332987855 4.83011240208675e-06 miRanda -0.127025858756614 9.29239246668325e-05 NA NA NA hsa-miR-130a-3p GJA1 0.163798739071237 0.031259491216363 -0.387095205558543 0.00724305167635957 MirTarget;miRNATAP -0.29710384281355 0.000733130919395938 NA NA NA hsa-miR-130b-3p GJA1 0.503911467685709 9.46590588950823e-08 -0.387095205558543 0.00724305167635957 MirTarget;miRNATAP -0.326077091230139 3.30561621279968e-07 NA NA NA hsa-miR-17-5p GJA1 0.0975751369167082 0.20621110214601 -0.387095205558543 0.00724305167635957 TargetScan -0.273225985718227 0.00459038465769816 NA NA NA hsa-miR-19a-3p GJA1 0.0466707843731911 0.576818938277755 -0.387095205558543 0.00724305167635957 MirTarget;miRNATAP -0.379060409365969 3.57664206413897e-07 NA NA NA hsa-miR-19b-3p GJA1 -0.0138427450847924 0.856506310673067 -0.387095205558543 0.00724305167635957 MirTarget;miRNATAP -0.554508446041767 3.21961481054881e-10 NA NA NA hsa-miR-582-3p GJA1 -0.11807589183011 0.304077332003677 -0.387095205558543 0.00724305167635957 MirTarget;PITA;miRNATAP -0.142673005867059 0.00759569256884532 NA NA NA hsa-miR-582-5p GJA1 -0.215764335500665 0.0760892640434509 -0.387095205558543 0.00724305167635957 miRNATAP -0.145310605955108 0.00293206609378715 NA NA NA hsa-miR-892a GJA1 -0.242011750672218 0.136146245118012 -0.387095205558543 0.00724305167635957 MirTarget;PITA -0.222938134758198 2.54811387815858e-09 NA NA NA hsa-miR-19b-3p GLIPR1 -0.0138427450847924 0.856506310673067 0.362592777181518 2.75995756570959e-05 mirMAP -0.195094602814843 0.000436942115720116 NA NA NA hsa-miR-20a-3p GLIPR1 0.102743778777997 0.19677865359751 0.362592777181518 2.75995756570959e-05 mirMAP -0.16191580259337 0.00061307996187886 NA NA NA hsa-miR-9-5p GLIPR1 -0.125377971246422 0.269896477802284 0.362592777181518 2.75995756570959e-05 mirMAP -0.558208108609485 3.15494756429763e-12 NA NA NA hsa-miR-124-3p GPX7 -0.506026514549291 0.0078056370358648 0.518260044856506 2.48234138524743e-12 miRNAWalker2_validate -0.118727170578026 1.03180652766054e-12 NA NA NA hsa-miR-129-5p GPX7 -0.567133990117126 0.00116152215679936 0.518260044856506 2.48234138524743e-12 miRanda -0.108340433512474 5.77907223858369e-09 NA NA NA hsa-miR-137 GPX7 -0.924849266740909 1.546832202049e-06 0.518260044856506 2.48234138524743e-12 miRanda;miRNATAP -0.147010141086055 2.74888202717373e-20 NA NA NA hsa-miR-29a-3p GPX7 -0.224140851576083 0.0349516103550236 0.518260044856506 2.48234138524743e-12 MirTarget;miRNATAP -0.209049089585567 1.01325545079884e-07 NA NA NA hsa-miR-29c-3p GPX7 -0.372180390387259 0.00202634431973208 0.518260044856506 2.48234138524743e-12 MirTarget;miRNATAP -0.176677793638749 1.11174633551714e-09 NA NA NA hsa-miR-767-5p GPX7 -0.551653504513145 2.61109058244854e-05 0.518260044856506 2.48234138524743e-12 miRNATAP -0.233596215113898 1.50599613241015e-22 NA NA NA hsa-miR-103a-3p ID2 -0.147443193527362 0.128400914654149 0.0826785901524438 0.215037394736801 miRNAWalker2_validate;miRTarBase -0.176527321139155 1.22534317324358e-05 NA NA NA hsa-miR-107 ID2 -0.121070851008387 0.198381281894242 0.0826785901524438 0.215037394736801 miRanda -0.106021757071936 6.1826776862116e-05 NA NA NA hsa-miR-19b-3p ID2 -0.0138427450847924 0.856506310673067 0.0826785901524438 0.215037394736801 MirTarget;miRNATAP -0.178060288299647 3.48969476978454e-07 NA NA NA hsa-miR-346 ID2 -0.577786425963268 2.10883270131593e-09 0.0826785901524438 0.215037394736801 miRanda -0.125955736557693 1.57664683474673e-07 NA NA NA hsa-miR-378a-3p ID2 0.251965146196782 0.0137483824840962 0.0826785901524438 0.215037394736801 miRNAWalker2_validate -0.147496042447875 5.30768409263466e-10 NA NA NA hsa-miR-326 IGFBP2 -0.631050656251074 8.83643450601471e-05 1.43290947623553 1.12093798037247e-17 miRanda -0.209306307466907 5.70686650615733e-06 NA NA NA hsa-miR-3065-5p IGFBP3 -0.262608140481507 0.0414570974148034 0.813873247049911 5.13040813514096e-07 MirTarget -0.197111855208535 0.000317701746457494 NA NA NA hsa-miR-374b-5p IGFBP3 -0.210113949579608 0.0056866083818614 0.813873247049911 5.13040813514096e-07 MirTarget -0.298786997614656 0.00453049747951356 NA NA NA hsa-miR-9-5p IGFBP3 -0.125377971246422 0.269896477802284 0.813873247049911 5.13040813514096e-07 MirTarget;miRNATAP -0.835295489754643 4.84694667135587e-08 NA NA NA hsa-miR-124-3p IGFBP4 -0.506026514549291 0.0078056370358648 0.577813521468223 8.43166787269048e-09 miRNAWalker2_validate -0.129729636339384 6.13320274594195e-09 NA NA NA hsa-miR-129-5p IGFBP4 -0.567133990117126 0.00116152215679936 0.577813521468223 8.43166787269048e-09 miRanda -0.202978203513892 6.86857376455642e-17 NA NA NA hsa-miR-326 IGFBP4 -0.631050656251074 8.83643450601471e-05 0.577813521468223 8.43166787269048e-09 MirTarget;miRanda -0.172825215985555 2.50205072348173e-11 NA NA NA hsa-miR-330-5p IGFBP4 -0.262932095995605 0.0465226565966658 0.577813521468223 8.43166787269048e-09 MirTarget;miRanda -0.15017423877991 3.20171173574415e-06 NA NA NA hsa-miR-375 IGFBP4 -0.0268401141324031 0.858358101444697 0.577813521468223 8.43166787269048e-09 miRanda -0.109412240328571 0.000107475883765053 NA NA NA hsa-miR-491-5p IGFBP4 -0.749881113074983 8.22859263179194e-09 0.577813521468223 8.43166787269048e-09 miRanda -0.250646392528984 1.49450902829511e-15 NA NA NA hsa-miR-7-5p IGFBP4 -0.244254069762734 0.193173919522103 0.577813521468223 8.43166787269048e-09 miRNAWalker2_validate -0.117122917445371 3.66788808827075e-07 NA NA NA hsa-miR-129-5p IL15 -0.567133990117126 0.00116152215679936 0.548696352183111 3.05512781066991e-05 miRanda -0.11824762489829 0.000455487507844168 NA NA NA hsa-miR-139-5p IL15 -0.647754756897633 2.15378307237163e-06 0.548696352183111 3.05512781066991e-05 miRanda -0.229020067896396 1.10469871548934e-07 NA NA NA hsa-miR-346 IL15 -0.577786425963268 2.10883270131593e-09 0.548696352183111 3.05512781066991e-05 miRanda -0.291029520996775 8.21701569497684e-07 NA NA NA hsa-miR-490-3p IL32 -0.834268051506884 5.26203010743215e-06 0.466032997626966 7.69980546140157e-05 miRanda -0.139383012367139 7.35429885205597e-07 NA NA NA hsa-miR-139-5p IL6 -0.647754756897633 2.15378307237163e-06 0.860210379772624 5.71029329538237e-06 miRanda -0.193255461876079 0.00224121799463508 NA NA NA hsa-miR-181a-5p INHBA -0.178215604431845 0.0700010802255601 -0.111178514068958 0.419730738622891 mirMAP -0.21980734414689 0.00906745955769609 NA NA NA hsa-miR-181b-5p INHBA 0.0260899284211646 0.768941836912518 -0.111178514068958 0.419730738622891 mirMAP -0.259906696166872 0.00224256513341453 NA NA NA hsa-miR-30b-5p INHBA -0.0858101016322106 0.263243418521854 -0.111178514068958 0.419730738622891 mirMAP -0.269174831076884 0.00461659150305601 NA NA NA hsa-miR-30c-5p INHBA -0.0469114469943097 0.565934557464627 -0.111178514068958 0.419730738622891 mirMAP -0.252109591297816 0.00826402161586394 NA NA NA hsa-miR-577 INHBA -0.382068371859275 0.0145513192729119 -0.111178514068958 0.419730738622891 mirMAP -0.116630482638817 0.00271533769710923 NA NA NA hsa-miR-9-5p INHBA -0.125377971246422 0.269896477802284 -0.111178514068958 0.419730738622891 mirMAP -0.495464738814837 0.000177388910911551 NA NA NA hsa-miR-139-5p ITGA2 -0.647754756897633 2.15378307237163e-06 0.355153037928839 0.00304131178560687 PITA;miRanda -0.159226995505735 5.04565253757112e-05 NA NA NA hsa-miR-19b-3p ITGA2 -0.0138427450847924 0.856506310673067 0.355153037928839 0.00304131178560687 MirTarget -0.223966443470452 0.00423394175567374 NA NA NA hsa-miR-137 ITGA5 -0.924849266740909 1.546832202049e-06 0.793342094273252 2.60153014639864e-16 miRNATAP -0.183465049215294 3.32771770329736e-18 NA NA NA hsa-miR-326 ITGA5 -0.631050656251074 8.83643450601471e-05 0.793342094273252 2.60153014639864e-16 PITA;miRanda;miRNATAP -0.101915908431353 9.11132766300263e-05 NA NA NA hsa-miR-338-3p ITGA5 -0.39963704679384 0.0034410643220691 0.793342094273252 2.60153014639864e-16 miRanda -0.214024001607437 1.88859538954314e-10 NA NA NA hsa-miR-346 ITGA5 -0.577786425963268 2.10883270131593e-09 0.793342094273252 2.60153014639864e-16 miRanda -0.367395525220409 3.97565367761327e-18 NA NA NA hsa-let-7a-3p ITGAV 0.0530563276543763 0.370749834463566 0.0990544191044433 0.158112078507138 MirTarget -0.226179494184483 6.5047593966468e-07 NA NA NA hsa-miR-7-1-3p ITGAV -0.0894475316162393 0.37322359785108 0.0990544191044433 0.158112078507138 mirMAP -0.110624915473632 4.68796749491555e-06 NA NA NA hsa-miR-92a-3p ITGAV 0.0407239381334659 0.643983393805961 0.0990544191044433 0.158112078507138 MirTarget;miRNATAP -0.117649981914186 0.00735494915611702 NA NA NA hsa-miR-129-5p ITGB1 -0.567133990117126 0.00116152215679936 0.371181257932731 2.75495842292235e-08 miRanda -0.102646377953306 2.01213240209488e-13 NA NA NA hsa-miR-139-5p ITGB1 -0.647754756897633 2.15378307237163e-06 0.371181257932731 2.75495842292235e-08 miRanda -0.157507949857377 8.78792578024261e-19 NA NA NA hsa-miR-9-3p ITGB1 -0.184945845984695 0.0290051908009009 0.371181257932731 2.75495842292235e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.316742979478369 1.03356062503789e-16 NA NA NA hsa-miR-139-5p ITGB3 -0.647754756897633 2.15378307237163e-06 0.895350443268113 1.2725318963024e-11 miRanda -0.336235853933377 1.03825075718253e-14 NA NA NA hsa-miR-338-3p ITGB3 -0.39963704679384 0.0034410643220691 0.895350443268113 1.2725318963024e-11 miRanda -0.26366444264679 2.00838730947514e-08 27431198 Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-767-3p ITGB3 -0.429854368420513 0.000821445291167688 0.895350443268113 1.2725318963024e-11 miRNATAP -0.173462997661818 0.000221793007799183 NA NA NA hsa-miR-1179 ITGB5 -0.117056451908751 0.310989525634765 -0.0173135223799843 0.843025832674222 mirMAP -0.138504371856984 1.35076920981542e-05 NA NA NA hsa-miR-139-5p ITGB5 -0.647754756897633 2.15378307237163e-06 -0.0173135223799843 0.843025832674222 miRanda -0.145436981829557 6.0927739548774e-08 NA NA NA hsa-miR-139-5p JUN -0.647754756897633 2.15378307237163e-06 0.37954584650033 7.46220464317962e-05 MirTarget;PITA;miRanda;miRNATAP -0.185022658773887 2.83059205114288e-11 25499265 In this study we report the identification of a novel negative feedback loop formed between miR-139 and its oncogenic target Jun; In this loop miR-139 could inhibit Jun expression by targeting a conserved site on its 3'-UTR whereas Jun could induce miR-139 expression in a dose dependent manner through a distant upstream regulatory element; Interestingly aberration in this loop was found in human gastric cancer where miR-139 was down-regulated and inversely correlated with Jun expression; Further functional analysis showed that restored expression of miR-139 in gastric cancer cells significantly induces apoptosis and inhibits cell migration and proliferation as well as tumour growth through targeting Jun; Given that miR-139 and Jun are deregulated in many cancers our findings here might have broader implication in other types of human cancers cell migration gastric cancer hsa-miR-17-5p LAMA3 0.0975751369167082 0.20621110214601 -0.327100673217928 0.00946413584299 TargetScan -0.393782118090754 8.62478299577863e-06 NA NA NA hsa-miR-217 LAMA3 0.540279882451941 0.00312206944061206 -0.327100673217928 0.00946413584299 PITA;miRanda -0.135270475140222 6.30793577085176e-06 NA NA NA hsa-miR-124-3p LAMC1 -0.506026514549291 0.0078056370358648 0.643575172906661 1.88021715964045e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109062363630864 1.34877803871189e-08 NA NA NA hsa-miR-129-5p LAMC1 -0.567133990117126 0.00116152215679936 0.643575172906661 1.88021715964045e-13 miRanda -0.137358273741041 8.7710329568346e-11 NA NA NA hsa-miR-139-5p LAMC1 -0.647754756897633 2.15378307237163e-06 0.643575172906661 1.88021715964045e-13 miRanda -0.267458058003669 6.97400330454346e-24 NA NA NA hsa-miR-153-3p LAMC1 -0.173449510253619 0.0654368045743418 0.643575172906661 1.88021715964045e-13 MirTarget -0.230289449771916 1.10315362637141e-08 NA NA NA hsa-miR-29a-3p LAMC1 -0.224140851576083 0.0349516103550236 0.643575172906661 1.88021715964045e-13 MirTarget;miRNATAP -0.138312325298085 0.00224607726447933 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.178522712044497 0.0856106432165465 0.643575172906661 1.88021715964045e-13 MirTarget;miRNATAP -0.146551772207787 0.000218138367082483 NA NA NA hsa-miR-29c-3p LAMC1 -0.372180390387259 0.00202634431973208 0.643575172906661 1.88021715964045e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109879902019624 0.00105589093987951 NA NA NA hsa-miR-338-3p LAMC1 -0.39963704679384 0.0034410643220691 0.643575172906661 1.88021715964045e-13 MirTarget;miRanda -0.235233133578316 2.91064562407468e-16 NA NA NA hsa-miR-374b-5p LAMC1 -0.210113949579608 0.0056866083818614 0.643575172906661 1.88021715964045e-13 mirMAP -0.148647334100688 0.00692929122136015 NA NA NA hsa-miR-433-3p LAMC1 -0.584416505057956 0.00091765848343232 0.643575172906661 1.88021715964045e-13 MirTarget -0.124945883929686 1.02553994694002e-09 NA NA NA hsa-miR-577 LAMC1 -0.382068371859275 0.0145513192729119 0.643575172906661 1.88021715964045e-13 PITA -0.114381225200383 1.2166650377122e-06 NA NA NA hsa-miR-7-1-3p LAMC1 -0.0894475316162393 0.37322359785108 0.643575172906661 1.88021715964045e-13 mirMAP -0.144734533518801 8.5353525077051e-05 NA NA NA hsa-miR-129-5p LOX -0.567133990117126 0.00116152215679936 0.641848475047754 1.88910713929415e-09 miRanda -0.114718669667137 3.36637790814221e-05 NA NA NA hsa-miR-181a-5p LOX -0.178215604431845 0.0700010802255601 0.641848475047754 1.88910713929415e-09 miRNATAP -0.202136890952596 0.00228740861752562 NA NA NA hsa-miR-181c-5p LOX -0.285631740307867 0.00281600994521758 0.641848475047754 1.88910713929415e-09 miRNATAP -0.197707051619127 0.00035139721773049 NA NA NA hsa-miR-577 LOX -0.382068371859275 0.0145513192729119 0.641848475047754 1.88910713929415e-09 mirMAP -0.111428267835361 0.000268420467249945 NA NA NA hsa-miR-767-5p LOX -0.551653504513145 2.61109058244854e-05 0.641848475047754 1.88910713929415e-09 miRNATAP -0.293816304104421 1.9618878579681e-16 NA NA NA hsa-miR-3065-5p LOXL1 -0.262608140481507 0.0414570974148034 0.826804287985085 1.7888032595835e-07 MirTarget -0.233055923832643 1.91131769161484e-05 NA NA NA hsa-miR-338-3p LOXL2 -0.39963704679384 0.0034410643220691 0.844032182250698 7.51211358348014e-13 miRanda -0.243197393191499 3.950304698454e-09 NA NA NA hsa-miR-342-3p LRP1 -0.125683829770877 0.105810751640137 0.009319505612293 0.899508193065921 miRanda -0.141517021694554 7.90194855663875e-06 NA NA NA hsa-miR-129-5p LUM -0.567133990117126 0.00116152215679936 0.714577514064964 5.60893764849109e-07 miRanda -0.146041434777813 7.39828217302776e-05 NA NA NA hsa-miR-193a-3p MAGEE1 0.395602305834739 0.00182611787714301 -0.615336450337878 5.08727331220161e-10 miRanda -0.145579134528851 2.21285729863251e-05 NA NA NA hsa-miR-30a-3p MAGEE1 0.0655410309550977 0.509541256241954 -0.615336450337878 5.08727331220161e-10 MirTarget -0.215573342030186 0.000123112673035263 NA NA NA hsa-miR-362-3p MAGEE1 0.032375035235532 0.736465332563774 -0.615336450337878 5.08727331220161e-10 miRanda -0.118373221586923 0.00813811759017559 NA NA NA hsa-miR-590-3p MAGEE1 0.312951515438396 0.000480455423843996 -0.615336450337878 5.08727331220161e-10 miRanda -0.238378657076442 5.01244972451254e-07 NA NA NA hsa-miR-129-5p MATN2 -0.567133990117126 0.00116152215679936 0.378388920893912 0.000453134191975528 miRanda -0.109953598982302 2.57301185569798e-05 NA NA NA hsa-miR-490-3p MATN2 -0.834268051506884 5.26203010743215e-06 0.378388920893912 0.000453134191975528 miRanda -0.162542517709883 2.07172022296205e-11 NA NA NA hsa-miR-491-3p MATN2 -0.523374665885358 1.93479565404951e-05 0.378388920893912 0.000453134191975528 miRNATAP -0.115938042955427 0.00145593446780334 NA NA NA hsa-miR-543 MATN2 -0.347737549779625 0.0157394585079683 0.378388920893912 0.000453134191975528 miRanda -0.159180309060528 4.71494443425711e-07 NA NA NA hsa-miR-107 MCM7 -0.121070851008387 0.198381281894242 0.304071192262941 2.6811439400517e-05 miRanda -0.199555025278988 8.62299180616376e-11 NA NA NA hsa-miR-193b-3p MCM7 0.0766333116224072 0.324723824453143 0.304071192262941 2.6811439400517e-05 miRNAWalker2_validate -0.11584232045451 0.00203242694148569 NA NA NA hsa-miR-222-3p MCM7 0.107117065575197 0.423818119725697 0.304071192262941 2.6811439400517e-05 miRNAWalker2_validate -0.153701545790602 2.37162666816492e-14 NA NA NA hsa-miR-34a-5p MCM7 0.143472919835524 0.211283228567057 0.304071192262941 2.6811439400517e-05 miRNAWalker2_validate -0.201268756136123 6.19699802686052e-17 NA NA NA hsa-miR-484 MCM7 -0.0190828819137732 0.802298900989652 0.304071192262941 2.6811439400517e-05 miRNAWalker2_validate -0.184154635598248 2.12714083905869e-06 NA NA NA hsa-miR-151a-5p MEST -0.0404897660305803 0.549545497147129 0.577340808103839 7.5694260374773e-10 MirTarget -0.316062536886262 2.21791656170303e-06 NA NA NA hsa-miR-29a-3p MEST -0.224140851576083 0.0349516103550236 0.577340808103839 7.5694260374773e-10 MirTarget;miRNATAP -0.261721209549845 7.44806620036706e-08 NA NA NA hsa-miR-29b-3p MEST -0.178522712044497 0.0856106432165465 0.577340808103839 7.5694260374773e-10 MirTarget;miRNATAP -0.313049454846683 1.13546327314225e-13 NA NA NA hsa-miR-29c-3p MEST -0.372180390387259 0.00202634431973208 0.577340808103839 7.5694260374773e-10 MirTarget;miRNATAP -0.217607029396351 1.4190237450415e-09 NA NA NA hsa-miR-3065-3p MEST -0.261348288537884 0.0343753235107924 0.577340808103839 7.5694260374773e-10 MirTarget;miRNATAP -0.171967232693394 3.03450797387925e-07 NA NA NA hsa-miR-326 MEST -0.631050656251074 8.83643450601471e-05 0.577340808103839 7.5694260374773e-10 miRanda;miRNATAP -0.105156253172504 1.70663349814708e-05 NA NA NA hsa-miR-330-5p MEST -0.262932095995605 0.0465226565966658 0.577340808103839 7.5694260374773e-10 miRanda;miRNATAP -0.116775205022344 0.000108533710450469 NA NA NA hsa-miR-491-3p MEST -0.523374665885358 1.93479565404951e-05 0.577340808103839 7.5694260374773e-10 MirTarget -0.20012336426278 3.74325899817017e-10 NA NA NA hsa-miR-491-5p MEST -0.749881113074983 8.22859263179194e-09 0.577340808103839 7.5694260374773e-10 miRanda -0.192488486642317 7.86909829469353e-11 NA NA NA hsa-miR-767-5p MEST -0.551653504513145 2.61109058244854e-05 0.577340808103839 7.5694260374773e-10 MirTarget;PITA;miRNATAP -0.15800529159466 2.42492891908412e-07 NA NA NA hsa-miR-129-2-3p MMP14 -0.6175132197013 0.000561573620904867 0.598485263471304 2.71058220103574e-07 mirMAP -0.204731043283281 3.37211477019527e-14 NA NA NA hsa-miR-181a-5p MMP14 -0.178215604431845 0.0700010802255601 0.598485263471304 2.71058220103574e-07 miRNATAP -0.299003180956252 1.43794693744998e-05 NA NA NA hsa-miR-9-5p MMP14 -0.125377971246422 0.269896477802284 0.598485263471304 2.71058220103574e-07 mirMAP -0.923501219834482 2.23766420508236e-18 NA NA NA hsa-miR-125a-5p MMP2 -0.0833349424517387 0.325440200253607 0.704014978384614 1.08365653245269e-12 miRanda -0.233365859256579 0.000140842599777966 NA NA NA hsa-miR-137 MMP2 -0.924849266740909 1.546832202049e-06 0.704014978384614 1.08365653245269e-12 miRanda -0.148796820220465 2.28486099058926e-12 26695142 miR-137 mimics downregulated B-CPAP cell proliferation colony formation ability and invasion with suppressed expression of cyclin E MMP2 p-ERK and p-AKT miR-137 inhibitor transfection in TPC-1 cell line showed the opposite effects thyroid cancer hsa-miR-29a-3p MMP2 -0.224140851576083 0.0349516103550236 0.704014978384614 1.08365653245269e-12 miRNATAP -0.294804906417144 9.02530238187708e-09 24130168 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC gastric cancer hsa-miR-29b-3p MMP2 -0.178522712044497 0.0856106432165465 0.704014978384614 1.08365653245269e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.279098360745868 5.04515764540177e-10 26155940;20657750;25866219;24130681;24130168;26063204 In this study we found that only miR-29b inhibited tumor cell migration and invasion by reducing MMP-2 activity via phospho-AKT/β-catenin signaling and stimulated a more epithelial-like morphology;Further a novel target with potential implications for invasion and metastasis matrix metallopeptidase-2 MMP-2 was identified and confirmed to be a miR-29b target in prostate cancer cells;miR 29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP 2; The impact of overexpression of miR-29b on putative target MMP-2 were subsequently confirmed via Western blot; Overexpression of miR-29b significantly decreased p<0.05 the protein level of MMP-2 which has previously been identified as a direct target of miR-29b; Thus our study demonstrated that overexpression of miR-29b inhibits tumor growth in part by targeting MMP-2;Since miR-29b plays a role in regulating the migration of cancer cells we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 MMP-2 thereby suppressing the migration of colon cancer cells; Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA; Western blotting and quantitative RT-PCR indicated that miR-29b down-regulated the expression of MMP2 at the protein and mRNA levels; Taken together our results demonstrate that miR-29b serves as a tumor metastasis suppressor which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression cell migration;metastasis;progression;;;metastasis glioblastoma;prostate cancer;esophageal cancer;colon cancer;gastric cancer;lung squamous cell cancer hsa-miR-29c-3p MMP2 -0.372180390387259 0.00202634431973208 0.704014978384614 1.08365653245269e-12 miRNATAP -0.262373922309043 3.72058795562015e-12 23936390;25863127 Furthermore the dual-luciferase reporter assay demonstrated that miR-29c inhibited the expression of the luciferase gene containing the 3'-UTRs of integrin β1 and MMP2 mRNA; Western blotting indicated that miR-29c downregulated the expression of integrin β1 and MMP2 at the protein level; Gelatin zymography analysis further confirmed that miR-29c decreased MMP2 enzyme activity;miR-29c suppresses cell migration and invasion by targeting the MMP2 3'UTR; miR-29c plays an important role in mediating pancreatic cancer metastasis to the liver by targeting MMP2 ;cell migration;metastasis lung cancer;pancreatic cancer hsa-miR-3065-3p MMP2 -0.261348288537884 0.0343753235107924 0.704014978384614 1.08365653245269e-12 miRNATAP -0.11426939767871 0.00138779733020552 NA NA NA hsa-miR-330-3p MMP2 -0.427388106938151 0.00300489284414266 0.704014978384614 1.08365653245269e-12 miRNATAP -0.172460053047175 1.96068699785787e-09 NA NA NA hsa-miR-338-3p MMP2 -0.39963704679384 0.0034410643220691 0.704014978384614 1.08365653245269e-12 miRNAWalker2_validate -0.202105497786416 1.49953035141337e-09 NA NA NA hsa-miR-101-3p MSX1 -0.132333931567244 0.241891922291381 0.21978303758948 0.00852007022948807 miRNATAP -0.126479454925305 0.00174094466325036 NA NA NA hsa-miR-129-5p MSX1 -0.567133990117126 0.00116152215679936 0.21978303758948 0.00852007022948807 miRanda -0.106010234354949 1.92428686822161e-07 NA NA NA hsa-miR-137 MSX1 -0.924849266740909 1.546832202049e-06 0.21978303758948 0.00852007022948807 miRanda -0.100740457482992 1.56357374742043e-08 NA NA NA hsa-miR-139-5p MSX1 -0.647754756897633 2.15378307237163e-06 0.21978303758948 0.00852007022948807 miRanda -0.191136669702169 1.5952910376793e-13 NA NA NA hsa-miR-105-5p MXRA5 -0.567459149851677 8.20858944634795e-06 0.672122430730266 5.83516238034167e-06 miRNATAP -0.19646171094123 0.000161134739214155 NA NA NA hsa-miR-135a-5p MXRA5 -0.122734612943241 0.196985964641886 0.672122430730266 5.83516238034167e-06 MirTarget -0.252038968213357 0.00038775408987107 NA NA NA hsa-miR-137 MXRA5 -0.924849266740909 1.546832202049e-06 0.672122430730266 5.83516238034167e-06 miRanda -0.154232537223365 3.58510309267897e-06 NA NA NA hsa-miR-139-5p MXRA5 -0.647754756897633 2.15378307237163e-06 0.672122430730266 5.83516238034167e-06 miRanda -0.284400242816402 4.89479403446541e-09 NA NA NA hsa-miR-346 MXRA5 -0.577786425963268 2.10883270131593e-09 0.672122430730266 5.83516238034167e-06 miRanda -0.34113742057361 3.07421407095197e-07 NA NA NA hsa-miR-9-5p MYLK -0.125377971246422 0.269896477802284 0.0112807618047226 0.911368311922206 miRNAWalker2_validate -0.71777453560342 8.82194727497631e-15 NA NA NA hsa-miR-124-3p NID2 -0.506026514549291 0.0078056370358648 0.595476528925858 3.90503577159981e-08 miRNAWalker2_validate -0.147264547841818 3.08844077264237e-09 NA NA NA hsa-miR-129-5p NID2 -0.567133990117126 0.00116152215679936 0.595476528925858 3.90503577159981e-08 PITA;miRanda;miRNATAP -0.188221172882602 6.12126003352395e-12 NA NA NA hsa-miR-139-5p NID2 -0.647754756897633 2.15378307237163e-06 0.595476528925858 3.90503577159981e-08 miRanda -0.240403353241968 9.56248540492737e-12 NA NA NA hsa-miR-490-3p NID2 -0.834268051506884 5.26203010743215e-06 0.595476528925858 3.90503577159981e-08 miRanda -0.17532297337157 9.86485473772406e-12 NA NA NA hsa-miR-508-3p NID2 -0.292045725850845 0.0158994578296519 0.595476528925858 3.90503577159981e-08 PITA;miRNATAP -0.112202699581237 0.00424356737140513 NA NA NA hsa-miR-1-3p NOTCH2 -0.218035884810576 0.125196862509753 0.0265373761477177 0.759991465966744 MirTarget -0.123736651017436 2.39217098657886e-08 NA NA NA hsa-miR-106a-5p NOTCH2 0.110074064773897 0.13045815990621 0.0265373761477177 0.759991465966744 miRNAWalker2_validate -0.204397218316821 1.12592965432191e-05 NA NA NA hsa-miR-146b-5p NOTCH2 0.441078059667297 0.000237619929889385 0.0265373761477177 0.759991465966744 miRanda -0.135030486429014 1.19722662261533e-06 NA NA NA hsa-miR-15a-5p NOTCH2 0.142658985373611 0.0536219185009004 0.0265373761477177 0.759991465966744 MirTarget -0.218279376305313 3.06264100050065e-05 NA NA NA hsa-miR-181a-5p NOTCH2 -0.178215604431845 0.0700010802255601 0.0265373761477177 0.759991465966744 miRNAWalker2_validate;MirTarget;mirMAP -0.131391300525628 0.00333206348449474 NA NA NA hsa-miR-181b-5p NOTCH2 0.0260899284211646 0.768941836912518 0.0265373761477177 0.759991465966744 MirTarget;mirMAP -0.219029917313777 1.08484264906831e-06 NA NA NA hsa-miR-29b-3p NOTCH2 -0.178522712044497 0.0856106432165465 0.0265373761477177 0.759991465966744 MirTarget -0.100449994874329 0.00373643393819674 NA NA NA hsa-miR-34a-5p NOTCH2 0.143472919835524 0.211283228567057 0.0265373761477177 0.759991465966744 miRNAWalker2_validate;miRNATAP -0.155403367407081 4.43885179634091e-08 NA NA NA hsa-miR-34c-5p NOTCH2 0.181931113688093 0.257266965617363 0.0265373761477177 0.759991465966744 PITA;miRanda;miRNATAP -0.136628313778413 1.9632919924199e-12 NA NA NA hsa-miR-9-5p NOTCH2 -0.125377971246422 0.269896477802284 0.0265373761477177 0.759991465966744 miRNATAP -0.224744730633258 0.00141456310007709 NA NA NA hsa-miR-140-5p NT5E 0.065063507103468 0.380452509211773 -0.012698940436966 0.889458880186527 miRanda -0.196473069150437 0.000334670855575227 NA NA NA hsa-miR-28-5p NT5E 0.104003572105781 0.153594705579534 -0.012698940436966 0.889458880186527 miRanda -0.246994443537209 7.53772418139271e-06 NA NA NA hsa-miR-30c-5p NT5E -0.0469114469943097 0.565934557464627 -0.012698940436966 0.889458880186527 miRNATAP -0.185590417772276 0.00170608453748771 NA NA NA hsa-miR-374a-5p NT5E 0.0121037060909277 0.865417963345881 -0.012698940436966 0.889458880186527 mirMAP -0.186371022325928 0.000990734060345954 NA NA NA hsa-miR-374b-5p NT5E -0.210113949579608 0.0056866083818614 -0.012698940436966 0.889458880186527 mirMAP -0.208068185563532 0.000193385864989131 NA NA NA hsa-miR-590-3p NT5E 0.312951515438396 0.000480455423843996 -0.012698940436966 0.889458880186527 PITA;miRanda -0.134691872141134 0.00124696226349001 NA NA NA hsa-miR-590-5p NT5E 0.16946027035949 0.0386004382081678 -0.012698940436966 0.889458880186527 miRanda -0.174502376565812 0.000156338409931797 NA NA NA hsa-miR-125a-3p NTM 0.183834985432376 0.106230647107917 -0.48664868608783 3.23102513388154e-09 miRanda -0.108252972387331 0.000291503227311837 NA NA NA hsa-miR-130b-5p NTM 0.413070888963592 1.98866876365509e-06 -0.48664868608783 3.23102513388154e-09 miRNATAP -0.283693030187032 4.15960739015534e-13 NA NA NA hsa-miR-28-5p NTM 0.104003572105781 0.153594705579534 -0.48664868608783 3.23102513388154e-09 miRanda;miRNATAP -0.219308180397492 9.82299265626742e-06 NA NA NA hsa-miR-3065-5p NTM -0.262608140481507 0.0414570974148034 -0.48664868608783 3.23102513388154e-09 mirMAP;miRNATAP -0.122128295308288 2.79327612211931e-06 NA NA NA hsa-miR-30c-5p NTM -0.0469114469943097 0.565934557464627 -0.48664868608783 3.23102513388154e-09 miRNATAP -0.183340222872111 0.000560132645781319 NA NA NA hsa-miR-339-5p NTM 0.273253751377152 0.0185300170790638 -0.48664868608783 3.23102513388154e-09 miRanda -0.132259975625095 4.57174460491187e-06 NA NA NA hsa-miR-942-5p NTM 0.331570745524138 0.00475398014468334 -0.48664868608783 3.23102513388154e-09 MirTarget -0.142705672958291 7.27878515488556e-07 NA NA NA hsa-miR-338-3p OXTR -0.39963704679384 0.0034410643220691 0.40487488442952 0.00757075795358588 miRanda -0.234564708398076 8.30478936349272e-06 NA NA NA hsa-miR-34c-5p OXTR 0.181931113688093 0.257266965617363 0.40487488442952 0.00757075795358588 miRanda -0.10820578513013 0.0077857680295663 NA NA NA hsa-miR-129-5p PCOLCE2 -0.567133990117126 0.00116152215679936 0.153534141721742 0.303587946897777 miRanda -0.110880749743917 0.00375113850852611 NA NA NA hsa-miR-26b-5p PCOLCE2 -0.0984536538762768 0.231803769574623 0.153534141721742 0.303587946897777 miRNAWalker2_validate -0.334507863092289 0.000439715077116274 NA NA NA hsa-miR-342-3p PCOLCE2 -0.125683829770877 0.105810751640137 0.153534141721742 0.303587946897777 miRanda -0.378859913700777 5.86529745504647e-05 NA NA NA hsa-miR-590-3p PCOLCE2 0.312951515438396 0.000480455423843996 0.153534141721742 0.303587946897777 MirTarget;miRanda -0.246780583530728 0.000711835099853398 NA NA NA hsa-miR-92b-3p PCOLCE2 -0.213968504161963 0.0523921855715716 0.153534141721742 0.303587946897777 MirTarget -0.451943961577117 2.99657215559487e-11 NA NA NA hsa-miR-9-5p PDGFRB -0.125377971246422 0.269896477802284 0.193259964403652 0.00272288258408316 MirTarget;miRNATAP -0.367539214293885 4.33000477969503e-12 NA NA NA hsa-miR-100-5p PFN2 0.0939087252225708 0.437623927320764 -0.306626789320093 2.15194390729408e-05 miRNAWalker2_validate -0.108332870019286 3.51539452309711e-06 NA NA NA hsa-miR-106a-5p PFN2 0.110074064773897 0.13045815990621 -0.306626789320093 2.15194390729408e-05 miRNATAP -0.100223988643164 0.00318088324638902 NA NA NA hsa-miR-150-5p PFN2 0.0645271721519611 0.513295658828718 -0.306626789320093 2.15194390729408e-05 miRNATAP -0.10250863492323 2.76457914938373e-05 NA NA NA hsa-miR-15b-3p PFN2 0.690804403863844 8.48784755123775e-09 -0.306626789320093 2.15194390729408e-05 miRNATAP -0.109944276143295 5.57378849522639e-09 NA NA NA hsa-miR-200b-3p PFN2 0.245768526504511 0.0580744465744737 -0.306626789320093 2.15194390729408e-05 TargetScan -0.118639826910815 4.63854926724089e-11 NA NA NA hsa-miR-2355-5p PFN2 0.00808596988211185 0.916165501155096 -0.306626789320093 2.15194390729408e-05 miRNATAP -0.124061001313987 9.96363080567103e-05 NA NA NA hsa-miR-30a-5p PFN2 -0.062942936611238 0.513851954700252 -0.306626789320093 2.15194390729408e-05 MirTarget;miRNATAP -0.236900040067512 1.9960893675403e-09 NA NA NA hsa-miR-320a PFN2 0.092135599636725 0.243028758989929 -0.306626789320093 2.15194390729408e-05 miRanda -0.156799036318965 2.08056743918712e-05 NA NA NA hsa-miR-320b PFN2 0.283477746304177 0.0005953763020907 -0.306626789320093 2.15194390729408e-05 miRanda -0.139754670378221 5.79958850149056e-07 NA NA NA hsa-miR-590-3p PFN2 0.312951515438396 0.000480455423843996 -0.306626789320093 2.15194390729408e-05 PITA;miRanda;mirMAP -0.114821152566215 8.99410007523933e-06 NA NA NA hsa-miR-93-5p PFN2 0.139766237971122 0.101057320076629 -0.306626789320093 2.15194390729408e-05 miRNATAP -0.146791297413949 0.00050095104062256 NA NA NA hsa-miR-139-5p PLAUR -0.647754756897633 2.15378307237163e-06 0.722626050671043 5.39188580921472e-11 miRanda -0.309559780840235 3.94032851245673e-18 NA NA NA hsa-miR-338-5p PLAUR -0.424003687569629 0.00246415720301323 0.722626050671043 5.39188580921472e-11 MirTarget -0.124905324771726 0.00038146624989623 NA NA NA hsa-miR-124-3p PLOD1 -0.506026514549291 0.0078056370358648 0.322978769581749 1.2401901884941e-06 miRNAWalker2_validate -0.109300081139031 5.16447210937956e-18 NA NA NA hsa-miR-124-3p PLOD3 -0.506026514549291 0.0078056370358648 0.347041741446031 3.20323846038423e-08 miRNAWalker2_validate -0.123618646629763 4.66990552626339e-24 NA NA NA hsa-miR-326 PLOD3 -0.631050656251074 8.83643450601471e-05 0.347041741446031 3.20323846038423e-08 miRNATAP -0.12324465195376 1.47387529367463e-17 NA NA NA hsa-miR-491-5p PLOD3 -0.749881113074983 8.22859263179194e-09 0.347041741446031 3.20323846038423e-08 miRanda -0.173246625135103 3.72625299625029e-23 NA NA NA hsa-miR-9-5p PMEPA1 -0.125377971246422 0.269896477802284 0.0689686890126024 0.243340416697383 mirMAP -0.215428815727531 9.16235066821449e-06 NA NA NA hsa-miR-92a-3p PMEPA1 0.0407239381334659 0.643983393805961 0.0689686890126024 0.243340416697383 miRNATAP -0.154550163809766 0.000119050626558458 NA NA NA hsa-miR-767-5p PMP22 -0.551653504513145 2.61109058244854e-05 0.0452307921911803 0.605508455364022 MirTarget;PITA;miRNATAP -0.287429247140336 2.16146230480896e-28 NA NA NA hsa-miR-9-5p PMP22 -0.125377971246422 0.269896477802284 0.0452307921911803 0.605508455364022 MirTarget;miRNATAP -0.418236502664086 5.94286332355855e-08 NA NA NA hsa-miR-139-5p POSTN -0.647754756897633 2.15378307237163e-06 1.81363654682376 4.05996484038834e-09 miRanda -0.358023364097083 0.000515291068190898 NA NA NA hsa-miR-219a-2-3p POSTN -0.57031561517274 0.000116587877956463 1.81363654682376 4.05996484038834e-09 MirTarget -0.750585351352458 1.24799813503088e-14 NA NA NA hsa-let-7d-5p PRRX1 0.111345229817909 0.0872634398336815 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.478254549469911 1.18612461479527e-13 NA NA NA hsa-let-7e-5p PRRX1 0.0471189209570344 0.657255455444655 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.122455770927769 0.00139195249860962 NA NA NA hsa-let-7g-5p PRRX1 -0.0253396334608382 0.742556489443668 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.241322636190309 3.65380011347856e-05 NA NA NA hsa-let-7i-5p PRRX1 0.0952853587923244 0.192120688957249 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.201507474107007 0.00081873811299509 NA NA NA hsa-miR-106a-5p PRRX1 0.110074064773897 0.13045815990621 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.240364716494028 1.52317126627953e-06 NA NA NA hsa-miR-1224-5p PRRX1 -0.53941068839383 0.00201058335769201 0.141670792066575 0.106318883741629 MirTarget -0.18807807594383 3.29092802475074e-23 NA NA NA hsa-miR-124-3p PRRX1 -0.506026514549291 0.0078056370358648 0.141670792066575 0.106318883741629 miRNAWalker2_validate;MirTarget;miRNATAP -0.191367708738807 1.52203357931487e-28 27578582;24705396 miR 124 regulates radiosensitivity of colorectal cancer cells by targeting PRRX1;MiR 124 Radiosensitizes human colorectal cancer cells by targeting PRRX1; We identified PRRX1 a new EMT inducer and stemness regulator as a novel direct target of miR-124 by using target prediction algorithms and luciferase assay; PRRX1 knockdown could sensitize CRC cells to IR similar to the effects caused by miR-124; Overexpression of PRRX1 in stably overexpressed-miR-124 cell lines could rescue the effects of radiosensitivity enhancement brought by miR-124; Taking these observations into consideration we illustrated that miR-124 could increase the radiosensitivity of CRC cells by blocking the expression of PRRX1 which indicated miR-124 could act as a great therapeutic target for CRC patients ; colorectal cancer;colorectal cancer hsa-miR-126-5p PRRX1 0.177332403948664 0.0711675116243123 0.141670792066575 0.106318883741629 mirMAP -0.185410961088386 3.90949233800136e-07 NA NA NA hsa-miR-139-5p PRRX1 -0.647754756897633 2.15378307237163e-06 0.141670792066575 0.106318883741629 miRanda -0.214286949760457 2.05743062163166e-17 NA NA NA hsa-miR-146b-3p PRRX1 0.283486177568242 0.0118918188864879 0.141670792066575 0.106318883741629 PITA -0.101796827820074 0.00109785385940719 24946010 The roles of the epithelial mesenchymal transition marker PRRX1 and miR 146b 5p in papillary thyroid carcinoma progression progression thyroid cancer hsa-miR-146b-5p PRRX1 0.441078059667297 0.000237619929889385 0.141670792066575 0.106318883741629 miRanda -0.106753042928567 0.000386095863379142 24946010 The roles of the epithelial mesenchymal transition marker PRRX1 and miR 146b 5p in papillary thyroid carcinoma progression; We conclude that papillary thyroid carcinoma tumor cells exhibit increased cancer stem cell-like features during TGF-β1-induced EMT that miR-146b-5p has a role in cell proliferation and invasion and that PRRX1 plays an important role in papillary thyroid carcinoma EMT and disease progression progression thyroid cancer hsa-miR-148b-5p PRRX1 0.127111784487801 0.188731110216917 0.141670792066575 0.106318883741629 MirTarget -0.129209474211299 0.000356110034069221 NA NA NA hsa-miR-154-5p PRRX1 -0.226468848904462 0.107380908211261 0.141670792066575 0.106318883741629 MirTarget -0.191247035899506 1.40848419445554e-15 NA NA NA hsa-miR-16-2-3p PRRX1 0.468816222075619 7.04377763166292e-05 0.141670792066575 0.106318883741629 MirTarget -0.107914133507676 0.00018857850802226 NA NA NA hsa-miR-1976 PRRX1 0.127074435034705 0.277235601775457 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.102346408919873 0.000481409049600965 NA NA NA hsa-miR-204-5p PRRX1 -0.288588537398065 0.113371226435822 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.128767039779917 5.20526649516944e-12 NA NA NA hsa-miR-20b-5p PRRX1 0.144541062989476 0.0992042333556543 0.141670792066575 0.106318883741629 MirTarget;miRNATAP -0.133396082481325 0.00168523367015938 NA NA NA hsa-miR-29a-5p PRRX1 -0.0697727833812678 0.350621682973119 0.141670792066575 0.106318883741629 mirMAP -0.135779838161093 0.00405286151712794 NA NA NA hsa-miR-29b-1-5p PRRX1 0.191335428755774 0.00846436454790702 0.141670792066575 0.106318883741629 MirTarget -0.131946151386497 0.00549632660448136 NA NA NA hsa-miR-323a-3p PRRX1 -0.391730191938842 0.0220003672777098 0.141670792066575 0.106318883741629 mirMAP -0.168697525517211 5.52368288659538e-18 NA NA NA hsa-miR-330-3p PRRX1 -0.427388106938151 0.00300489284414266 0.141670792066575 0.106318883741629 PITA;miRNATAP -0.179192530460112 1.35046781985633e-14 NA NA NA hsa-miR-335-3p PRRX1 0.34540584335595 0.00043848660222294 0.141670792066575 0.106318883741629 MirTarget;mirMAP -0.127851310660656 0.00043657595531626 NA NA NA hsa-miR-338-3p PRRX1 -0.39963704679384 0.0034410643220691 0.141670792066575 0.106318883741629 miRanda -0.138029551863811 5.28108486159439e-07 NA NA NA hsa-miR-340-5p PRRX1 -0.110504550202736 0.20522426193476 0.141670792066575 0.106318883741629 mirMAP -0.114313000319287 0.00685353656584989 NA NA NA hsa-miR-361-3p PRRX1 -0.0798653643614555 0.271064714084553 0.141670792066575 0.106318883741629 PITA -0.363806952886205 1.22697803221204e-11 NA NA NA hsa-miR-3928-3p PRRX1 -0.0453713200445216 0.630622646659965 0.141670792066575 0.106318883741629 MirTarget -0.115774042719414 0.00167272223460583 NA NA NA hsa-miR-485-3p PRRX1 -0.530677478972593 0.00148549219838911 0.141670792066575 0.106318883741629 PITA -0.168539813584856 2.77796325786087e-17 NA NA NA hsa-miR-584-5p PRRX1 -0.201233692659484 0.189661888876195 0.141670792066575 0.106318883741629 MirTarget -0.112087243965642 6.10890391624612e-07 NA NA NA hsa-miR-664a-3p PRRX1 0.0413918462467198 0.611334357897022 0.141670792066575 0.106318883741629 mirMAP -0.222581967974273 2.65899158300504e-07 NA NA NA hsa-miR-7-1-3p PRRX1 -0.0894475316162393 0.37322359785108 0.141670792066575 0.106318883741629 mirMAP -0.375162904432344 2.0907484521985e-30 NA NA NA hsa-miR-98-5p PRRX1 -0.0806971683871618 0.251777941211683 0.141670792066575 0.106318883741629 MirTarget -0.34225356448271 4.69379859108352e-10 NA NA NA hsa-miR-129-5p PTX3 -0.567133990117126 0.00116152215679936 0.949207819870183 5.94256337900862e-12 miRanda -0.184708357961068 2.50007087221503e-07 NA NA NA hsa-miR-139-5p PTX3 -0.647754756897633 2.15378307237163e-06 0.949207819870183 5.94256337900862e-12 miRanda -0.303744194667391 3.22261101717322e-11 NA NA NA hsa-miR-29a-3p PTX3 -0.224140851576083 0.0349516103550236 0.949207819870183 5.94256337900862e-12 MirTarget -0.225243200681322 0.00304566612887317 NA NA NA hsa-miR-29b-3p PTX3 -0.178522712044497 0.0856106432165465 0.949207819870183 5.94256337900862e-12 MirTarget -0.182517698056509 0.00624977340297341 NA NA NA hsa-miR-326 PTX3 -0.631050656251074 8.83643450601471e-05 0.949207819870183 5.94256337900862e-12 miRanda -0.191599968610305 3.77531233422303e-07 NA NA NA hsa-miR-101-5p QSOX1 -0.263105484860745 0.00306900408113868 0.083625188842122 0.161747276763344 mirMAP -0.115857569672082 5.09889721035759e-06 NA NA NA hsa-miR-135a-5p QSOX1 -0.122734612943241 0.196985964641886 0.083625188842122 0.161747276763344 mirMAP -0.157751422598363 3.10105443986466e-11 NA NA NA hsa-miR-29a-5p QSOX1 -0.0697727833812678 0.350621682973119 0.083625188842122 0.161747276763344 mirMAP -0.127303811424048 2.49800170020375e-05 NA NA NA hsa-miR-92b-3p QSOX1 -0.213968504161963 0.0523921855715716 0.083625188842122 0.161747276763344 mirMAP -0.184163837566496 6.80022829289475e-16 NA NA NA hsa-miR-93-3p QSOX1 0.0778767956494004 0.272224943247293 0.083625188842122 0.161747276763344 mirMAP -0.196952752037864 1.10480450213709e-09 NA NA NA hsa-miR-195-3p RGS4 0.100105455903079 0.133362389112338 -0.563196086792617 0.00784529202932 MirTarget;miRNATAP -0.379730535660904 0.00837642956746362 NA NA NA hsa-miR-19a-3p RHOB 0.0466707843731911 0.576818938277755 -0.292242951402677 0.00139037633630877 MirTarget;miRNATAP -0.123174783134757 0.00314273221826128 26041879 Ras homolog family member B RHOB was identified as a direct target of miR-19a pancreatic cancer hsa-miR-19b-3p RHOB -0.0138427450847924 0.856506310673067 -0.292242951402677 0.00139037633630877 MirTarget;miRNATAP -0.174039382454089 0.000452884714234349 NA NA NA hsa-miR-335-5p RHOB 0.0938511632756978 0.336889056387694 -0.292242951402677 0.00139037633630877 miRNAWalker2_validate -0.130774850428877 0.000159473430212958 NA NA NA hsa-miR-940 RHOB -0.0183807673806575 0.881747775878136 -0.292242951402677 0.00139037633630877 MirTarget -0.129972093951749 1.08867172307447e-06 NA NA NA hsa-miR-139-5p SAT1 -0.647754756897633 2.15378307237163e-06 0.255272986728413 0.000357264508817473 miRanda -0.103290938448159 1.51092330416243e-07 NA NA NA hsa-miR-9-3p SAT1 -0.184945845984695 0.0290051908009009 0.255272986728413 0.000357264508817473 MirTarget;miRNATAP -0.131581293119625 0.00188720258429099 NA NA NA hsa-miR-421 SCG2 -0.171573235029879 0.0518112933651029 0.0679194633041575 0.638804929668455 PITA;miRanda;miRNATAP -0.464052705787575 2.80026532929767e-11 NA NA NA hsa-miR-505-3p SCG2 0.115486008167472 0.109833720698312 0.0679194633041575 0.638804929668455 MirTarget -0.891599366570737 1.50089065388273e-24 NA NA NA hsa-miR-590-3p SCG2 0.312951515438396 0.000480455423843996 0.0679194633041575 0.638804929668455 miRanda -0.284774031767645 3.81273115639168e-05 NA NA NA hsa-miR-98-5p SCG2 -0.0806971683871618 0.251777941211683 0.0679194633041575 0.638804929668455 miRNAWalker2_validate -0.434218696045012 1.40489841108052e-05 NA NA NA hsa-miR-125a-5p SDC1 -0.0833349424517387 0.325440200253607 0.945050147298663 1.55209252921194e-15 mirMAP -0.23345659178572 0.00262483988547733 NA NA NA hsa-miR-125b-5p SDC1 -0.0119698382910496 0.890233923197358 0.945050147298663 1.55209252921194e-15 mirMAP -0.284392448155053 0.00225365110570422 NA NA NA hsa-miR-330-3p SDC1 -0.427388106938151 0.00300489284414266 0.945050147298663 1.55209252921194e-15 mirMAP -0.107051798640283 0.00358833519215036 NA NA NA hsa-miR-338-3p SDC1 -0.39963704679384 0.0034410643220691 0.945050147298663 1.55209252921194e-15 miRanda -0.146394379524292 0.000609364752225489 NA NA NA hsa-miR-488-3p SDC1 -0.257955761012568 0.00280795162806256 0.945050147298663 1.55209252921194e-15 mirMAP -0.176354746529225 0.00520130661295146 NA NA NA hsa-miR-491-5p SDC1 -0.749881113074983 8.22859263179194e-09 0.945050147298663 1.55209252921194e-15 miRanda -0.200704596141966 4.55578557196605e-07 NA NA NA hsa-miR-9-5p SDC1 -0.125377971246422 0.269896477802284 0.945050147298663 1.55209252921194e-15 miRNAWalker2_validate;miRNATAP -0.807954539886206 1.86328574966475e-12 NA NA NA hsa-miR-130b-3p SDC4 0.503911467685709 9.46590588950823e-08 -0.122041312433316 0.46084571562874 MirTarget -0.283353084530411 0.00020231593205631 NA NA NA hsa-miR-124-3p SERPINE1 -0.506026514549291 0.0078056370358648 1.27620546981704 1.91626732714512e-12 miRNAWalker2_validate -0.11053232774917 0.00933875755402922 NA NA NA hsa-miR-129-5p SERPINE1 -0.567133990117126 0.00116152215679936 1.27620546981704 1.91626732714512e-12 miRanda -0.136388531449073 0.00376304958296275 NA NA NA hsa-miR-138-5p SERPINE1 -0.616087649920851 1.35200027885729e-05 1.27620546981704 1.91626732714512e-12 miRNAWalker2_validate -0.27183048471367 1.58790910020002e-06 NA NA NA hsa-miR-767-3p SERPINE1 -0.429854368420513 0.000821445291167688 1.27620546981704 1.91626732714512e-12 PITA -0.360745702058261 1.27615948946032e-08 NA NA NA hsa-miR-146b-5p SERPINE2 0.441078059667297 0.000237619929889385 -0.313960469328091 4.5724691219799e-05 miRanda -0.120039846448774 5.40199509529217e-07 NA NA NA hsa-miR-16-5p SERPINE2 0.246024668671282 0.00346042804503716 -0.313960469328091 4.5724691219799e-05 miRNAWalker2_validate -0.121849027485315 0.00171138382292319 NA NA NA hsa-miR-186-5p SERPINE2 0.0606381894130505 0.514217717592464 -0.313960469328091 4.5724691219799e-05 MirTarget -0.206542862597814 1.73564478558191e-10 NA NA NA hsa-miR-30e-3p SERPINE2 0.00173769765874887 0.984965501547409 -0.313960469328091 4.5724691219799e-05 miRNAWalker2_validate -0.190195442676387 3.19491929516681e-06 NA NA NA hsa-miR-361-5p SERPINE2 0.0107519600643302 0.882230614095565 -0.313960469328091 4.5724691219799e-05 miRanda -0.17252096490945 0.000265695496033646 NA NA NA hsa-miR-542-3p SERPINE2 0.0835995677900829 0.403838744494071 -0.313960469328091 4.5724691219799e-05 PITA;miRanda;miRNATAP -0.103398558813819 0.000725592394688205 NA NA NA hsa-miR-590-3p SERPINE2 0.312951515438396 0.000480455423843996 -0.313960469328091 4.5724691219799e-05 PITA;miRanda;mirMAP -0.152231924613118 6.63408638112615e-07 NA NA NA hsa-miR-124-3p SERPINH1 -0.506026514549291 0.0078056370358648 0.849993739099297 4.59473510522219e-17 miRNAWalker2_validate -0.190153179773038 4.35675524072462e-17 NA NA NA hsa-miR-29a-3p SERPINH1 -0.224140851576083 0.0349516103550236 0.849993739099297 4.59473510522219e-17 miRNATAP -0.252966643033274 2.79398273209594e-06 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA 29a in lung cancer with idiopathic pulmonary fibrosis; Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF suggesting that these genes are involved in the pathogenesis of these two diseases.Journal of Human Genetics advance online publication 4 August 2016; doi:10.1038/jhg.2016.99 staging lung cancer hsa-miR-29b-3p SERPINH1 -0.178522712044497 0.0856106432165465 0.849993739099297 4.59473510522219e-17 miRNATAP -0.161549768059797 0.000691653777931084 NA NA NA hsa-miR-29c-3p SERPINH1 -0.372180390387259 0.00202634431973208 0.849993739099297 4.59473510522219e-17 miRNATAP -0.199479535551335 6.08063618192838e-07 NA NA NA hsa-miR-346 SERPINH1 -0.577786425963268 2.10883270131593e-09 0.849993739099297 4.59473510522219e-17 miRNATAP -0.423164210188046 3.18113884521709e-22 NA NA NA hsa-miR-129-5p SFRP4 -0.567133990117126 0.00116152215679936 0.837599072525803 4.88438094021192e-08 miRanda -0.175321879354888 9.76199357711033e-06 NA NA NA hsa-miR-346 SFRP4 -0.577786425963268 2.10883270131593e-09 0.837599072525803 4.88438094021192e-08 miRanda;miRNATAP -0.391247031336864 1.70313037083912e-08 NA NA NA hsa-miR-30c-5p SGCB -0.0469114469943097 0.565934557464627 0.0827998152271956 0.11437847277475 miRNATAP -0.10591875246207 4.40710778952017e-05 NA NA NA hsa-miR-146b-5p SGCD 0.441078059667297 0.000237619929889385 -0.615686119216908 6.98733992692406e-09 mirMAP -0.270621152970462 6.02386883890966e-12 NA NA NA hsa-miR-15a-5p SGCD 0.142658985373611 0.0536219185009004 -0.615686119216908 6.98733992692406e-09 miRNATAP -0.339755556461373 5.56432443692574e-06 NA NA NA hsa-miR-15b-5p SGCD 0.592863156692837 1.41971517354055e-10 -0.615686119216908 6.98733992692406e-09 miRNATAP -0.426396324713584 3.96417486019144e-17 NA NA NA hsa-miR-16-2-3p SGCD 0.468816222075619 7.04377763166292e-05 -0.615686119216908 6.98733992692406e-09 mirMAP -0.188656705581863 8.07798865416262e-07 NA NA NA hsa-miR-16-5p SGCD 0.246024668671282 0.00346042804503716 -0.615686119216908 6.98733992692406e-09 miRNATAP -0.295403405720597 4.10435662398817e-06 NA NA NA hsa-miR-200c-3p SGCD 0.413752622631695 8.6936333715621e-06 -0.615686119216908 6.98733992692406e-09 mirMAP -0.12985485976365 0.00839654592067635 NA NA NA hsa-miR-21-3p SGCD 1.3484283943822 2.0036022227401e-17 -0.615686119216908 6.98733992692406e-09 mirMAP -0.146841898651537 2.02780862537972e-07 NA NA NA hsa-miR-217 SGCD 0.540279882451941 0.00312206944061206 -0.615686119216908 6.98733992692406e-09 miRanda -0.115267592622433 3.59719754331732e-06 NA NA NA hsa-miR-25-3p SGCD 0.316649850160985 0.000777982468387578 -0.615686119216908 6.98733992692406e-09 mirMAP -0.31330821735365 7.45608553362815e-07 NA NA NA hsa-miR-30a-3p SGCD 0.0655410309550977 0.509541256241954 -0.615686119216908 6.98733992692406e-09 mirMAP -0.173972594911938 0.00392413262733171 NA NA NA hsa-miR-335-3p SGCD 0.34540584335595 0.00043848660222294 -0.615686119216908 6.98733992692406e-09 mirMAP -0.35851891360063 3.55090800349275e-14 NA NA NA hsa-miR-335-5p SGCD 0.0938511632756978 0.336889056387694 -0.615686119216908 6.98733992692406e-09 miRNAWalker2_validate;miRNATAP -0.248632066731076 1.69559041502351e-07 NA NA NA hsa-miR-339-5p SGCD 0.273253751377152 0.0185300170790638 -0.615686119216908 6.98733992692406e-09 PITA;miRNATAP -0.159976344286489 4.98018427952521e-05 NA NA NA hsa-miR-664a-3p SGCD 0.0413918462467198 0.611334357897022 -0.615686119216908 6.98733992692406e-09 mirMAP -0.163371188421128 0.00486591567170594 NA NA NA hsa-miR-93-5p SGCD 0.139766237971122 0.101057320076629 -0.615686119216908 6.98733992692406e-09 mirMAP -0.257707489703463 0.00194722935980784 NA NA NA hsa-miR-324-5p SLC6A8 0.0183370482495953 0.842996782677271 -0.0776875312757657 0.216634573661937 miRanda -0.10323731546328 4.22185858290806e-06 NA NA NA hsa-miR-542-3p SLC6A8 0.0835995677900829 0.403838744494071 -0.0776875312757657 0.216634573661937 miRanda -0.103156768098047 4.36222526380434e-06 NA NA NA hsa-miR-92a-3p SLC6A8 0.0407239381334659 0.643983393805961 -0.0776875312757657 0.216634573661937 miRNAWalker2_validate -0.103564414275957 0.00509846296605721 NA NA NA hsa-miR-3065-5p SLIT2 -0.262608140481507 0.0414570974148034 -0.170483256834865 0.335810749519703 mirMAP -0.193132974456974 0.00138630794595871 NA NA NA hsa-miR-454-3p SLIT3 0.177318549827649 0.0120865170334418 -0.0347734761461953 0.790087170994632 mirMAP -0.224050439844028 0.00772672043752792 NA NA NA hsa-miR-9-5p SLIT3 -0.125377971246422 0.269896477802284 -0.0347734761461953 0.790087170994632 mirMAP -0.881792884442899 5.43633385047911e-13 NA NA NA hsa-miR-3622a-3p SNAI2 0.0389203848593471 0.75605812962459 0.420616853894134 0.000182314677489613 MirTarget;miRNATAP -0.115397915117584 0.00417891997901791 NA NA NA hsa-miR-9-5p SNAI2 -0.125377971246422 0.269896477802284 0.420616853894134 0.000182314677489613 miRNAWalker2_validate -0.515710271997973 1.71483886465132e-06 NA NA NA hsa-miR-105-5p SNTB1 -0.567459149851677 8.20858944634795e-06 -0.0554902268737107 0.532021669392082 miRNATAP -0.182548183976005 4.32272685916706e-10 NA NA NA hsa-miR-1179 SNTB1 -0.117056451908751 0.310989525634765 -0.0554902268737107 0.532021669392082 MirTarget -0.171019752085547 1.67751174303499e-07 NA NA NA hsa-miR-139-5p SNTB1 -0.647754756897633 2.15378307237163e-06 -0.0554902268737107 0.532021669392082 miRanda -0.169007872561447 8.92787704744519e-10 NA NA NA hsa-miR-335-3p SNTB1 0.34540584335595 0.00043848660222294 -0.0554902268737107 0.532021669392082 mirMAP -0.10763238865819 0.00601164487977463 NA NA NA hsa-miR-335-5p SNTB1 0.0938511632756978 0.336889056387694 -0.0554902268737107 0.532021669392082 miRNAWalker2_validate -0.130204412997006 0.000776475470598139 NA NA NA hsa-miR-338-3p SNTB1 -0.39963704679384 0.0034410643220691 -0.0554902268737107 0.532021669392082 miRanda -0.121857029362125 4.09852602705756e-05 NA NA NA hsa-miR-767-3p SNTB1 -0.429854368420513 0.000821445291167688 -0.0554902268737107 0.532021669392082 PITA -0.212698694835666 1.96851292064922e-13 NA NA NA hsa-miR-145-3p SPARC 0.110543172922298 0.294150620210019 -0.352345598931326 0.00284630699754643 MirTarget -0.12578081064154 0.00289347930693501 NA NA NA hsa-miR-19a-3p SPARC 0.0466707843731911 0.576818938277755 -0.352345598931326 0.00284630699754643 mirMAP -0.281596106405209 3.78773256734821e-07 NA NA NA hsa-miR-203a-3p SPARC -0.393041310603753 0.0191851699904077 -0.352345598931326 0.00284630699754643 MirTarget -0.116018135895711 1.03735089542599e-05 NA NA NA hsa-miR-29b-3p SPARC -0.178522712044497 0.0856106432165465 -0.352345598931326 0.00284630699754643 miRNATAP -0.167632917775212 0.000479414253706488 NA NA NA hsa-miR-335-3p SPARC 0.34540584335595 0.00043848660222294 -0.352345598931326 0.00284630699754643 MirTarget -0.262316799076375 1.65243733782532e-08 NA NA NA hsa-miR-361-5p SPARC 0.0107519600643302 0.882230614095565 -0.352345598931326 0.00284630699754643 MirTarget -0.325803280074307 1.8127975057108e-05 NA NA NA hsa-miR-432-5p SPARC -0.214242438141977 0.166186087759946 -0.352345598931326 0.00284630699754643 MirTarget;miRNATAP -0.124450598277295 1.3219480997091e-05 NA NA NA hsa-miR-504-5p SPARC -0.510726779625117 6.12122269907368e-05 -0.352345598931326 0.00284630699754643 MirTarget -0.143922814575463 4.37797951252539e-05 NA NA NA hsa-miR-592 SPARC 0.0170005651576508 0.876633091134809 -0.352345598931326 0.00284630699754643 MirTarget -0.325462245264391 2.3848484816622e-16 NA NA NA hsa-miR-7-1-3p SPARC -0.0894475316162393 0.37322359785108 -0.352345598931326 0.00284630699754643 mirMAP -0.274759655006353 4.60997481029792e-10 NA NA NA hsa-miR-125a-3p SPOCK1 0.183834985432376 0.106230647107917 -0.367296952842921 0.000842959342335263 miRanda -0.109132412028107 0.0070344117836733 NA NA NA hsa-miR-130b-3p SPOCK1 0.503911467685709 9.46590588950823e-08 -0.367296952842921 0.000842959342335263 MirTarget -0.209389524885207 1.7334615641897e-05 NA NA NA hsa-miR-135a-5p SPOCK1 -0.122734612943241 0.196985964641886 -0.367296952842921 0.000842959342335263 miRNATAP -0.219945291154861 8.10807517324613e-06 NA NA NA hsa-miR-19a-3p SPOCK1 0.0466707843731911 0.576818938277755 -0.367296952842921 0.000842959342335263 MirTarget -0.157613448948322 0.00578038188941618 NA NA NA hsa-miR-19b-3p SPOCK1 -0.0138427450847924 0.856506310673067 -0.367296952842921 0.000842959342335263 MirTarget -0.183548833585718 0.00701245502529467 NA NA NA hsa-miR-23a-3p SPOCK1 0.334693010651106 0.00144448147063433 -0.367296952842921 0.000842959342335263 MirTarget;miRNATAP -0.180594285766911 0.000242135019659355 NA NA NA hsa-miR-301a-3p SPOCK1 0.00956875714542704 0.916380325220259 -0.367296952842921 0.000842959342335263 MirTarget -0.281394388159696 5.4504749064108e-08 NA NA NA hsa-miR-3065-5p SPOCK1 -0.262608140481507 0.0414570974148034 -0.367296952842921 0.000842959342335263 MirTarget;miRNATAP -0.140557640356728 6.91829945673701e-05 NA NA NA hsa-miR-454-3p SPOCK1 0.177318549827649 0.0120865170334418 -0.367296952842921 0.000842959342335263 MirTarget -0.26737166512805 6.69406150544634e-05 NA NA NA hsa-miR-590-3p SPOCK1 0.312951515438396 0.000480455423843996 -0.367296952842921 0.000842959342335263 PITA;miRanda;mirMAP -0.165574886885532 0.0010893527487618 NA NA NA hsa-miR-590-5p SPOCK1 0.16946027035949 0.0386004382081678 -0.367296952842921 0.000842959342335263 MirTarget;miRanda;mirMAP -0.209406711091854 0.000188707505038901 NA NA NA hsa-miR-671-5p SPOCK1 0.379677704170736 0.000129391032677459 -0.367296952842921 0.000842959342335263 MirTarget;PITA -0.145566314110759 0.00135449355982374 NA NA NA hsa-miR-139-5p SPP1 -0.647754756897633 2.15378307237163e-06 0.447976109877716 0.00440666771572369 miRanda -0.244822467822024 1.08036600087553e-06 NA NA NA hsa-miR-128-3p TAGLN -0.781932174412672 7.1812756321342e-10 0.283423008662774 0.00367224168165484 miRNAWalker2_validate -0.179392424200451 1.84112983988039e-07 NA NA NA hsa-miR-9-5p TAGLN -0.125377971246422 0.269896477802284 0.283423008662774 0.00367224168165484 miRNAWalker2_validate -0.419352965802283 2.12224263245723e-06 NA NA NA hsa-miR-139-5p TGFB1 -0.647754756897633 2.15378307237163e-06 0.188661409906809 0.0283645098828165 miRanda -0.257914873895623 5.01185822136258e-24 NA NA NA hsa-miR-543 TGFBI -0.347737549779625 0.0157394585079683 0.360137241786584 0.0160166225015352 PITA;miRanda;miRNATAP -0.239726796811963 1.62203309198268e-07 NA NA NA hsa-miR-9-5p TGFBI -0.125377971246422 0.269896477802284 0.360137241786584 0.0160166225015352 miRNAWalker2_validate;miRTarBase -0.818649421728258 6.82383762982284e-09 NA NA NA hsa-let-7d-5p TGFBR3 0.111345229817909 0.0872634398336815 -0.300599922020896 0.000663908632465181 MirTarget -0.207114130352629 0.00332925443546992 NA NA NA hsa-miR-15b-5p TGFBR3 0.592863156692837 1.41971517354055e-10 -0.300599922020896 0.000663908632465181 MirTarget;miRNATAP -0.197782413700188 2.15739104521996e-06 NA NA NA hsa-miR-181b-5p TGFBR3 0.0260899284211646 0.768941836912518 -0.300599922020896 0.000663908632465181 mirMAP -0.252922004935925 1.02120722775238e-06 NA NA NA hsa-miR-18a-5p TGFBR3 0.175320895022849 0.0732549187136286 -0.300599922020896 0.000663908632465181 MirTarget -0.119606923481921 0.00149017696730178 NA NA NA hsa-miR-335-3p TGFBR3 0.34540584335595 0.00043848660222294 -0.300599922020896 0.000663908632465181 mirMAP -0.189389209482409 9.93553522691547e-07 NA NA NA hsa-miR-423-5p TGFBR3 0.0965587900813789 0.148039180704338 -0.300599922020896 0.000663908632465181 MirTarget -0.222486392122688 0.000362318898251134 NA NA NA hsa-miR-424-5p TGFBR3 0.25140374049676 0.00709934939774983 -0.300599922020896 0.000663908632465181 MirTarget;miRNATAP -0.158007631536378 0.000132407643254955 NA NA NA hsa-miR-450b-5p TGFBR3 0.270544879013992 0.00801537838499562 -0.300599922020896 0.000663908632465181 mirMAP -0.263251533831174 2.74896878741272e-13 NA NA NA hsa-miR-582-5p TGFBR3 -0.215764335500665 0.0760892640434509 -0.300599922020896 0.000663908632465181 mirMAP -0.151091507774452 4.49479065475997e-07 NA NA NA hsa-miR-93-5p TGM2 0.139766237971122 0.101057320076629 0.239517419531726 0.0015325878151354 MirTarget -0.196675768604499 0.000331018813541801 NA NA NA hsa-miR-338-3p THBS1 -0.39963704679384 0.0034410643220691 0.542687032308904 0.000869835800177595 MirTarget;PITA;miRanda -0.218145983536744 0.000122986602033708 NA NA NA hsa-miR-106b-5p THBS2 0.167096183547615 0.0497544396383451 0.100434752325962 0.25920490224938 MirTarget -0.141807984689074 0.00446283348207612 NA NA NA hsa-miR-17-5p THBS2 0.0975751369167082 0.20621110214601 0.100434752325962 0.25920490224938 MirTarget;TargetScan -0.195108446647177 0.00119192440747675 NA NA NA hsa-miR-20a-5p THBS2 -0.0115865752288853 0.887069448776018 0.100434752325962 0.25920490224938 MirTarget -0.162285632609941 0.00329046667446248 NA NA NA hsa-miR-125a-5p THY1 -0.0833349424517387 0.325440200253607 -0.194578549150947 0.0468536353935265 miRanda -0.189783653950776 0.000865912813411394 NA NA NA hsa-miR-892a TIMP1 -0.242011750672218 0.136146245118012 1.2758204329214 2.71074727221847e-14 miRNATAP -0.177216144886376 0.000183523153365962 NA NA NA hsa-let-7a-3p TIMP3 0.0530563276543763 0.370749834463566 -0.245539739799964 0.00694219454447029 mirMAP;miRNATAP -0.180841347915045 0.00370037304939162 NA NA NA hsa-let-7b-3p TIMP3 -0.00495618733298731 0.952288980686967 -0.245539739799964 0.00694219454447029 mirMAP;miRNATAP -0.129463603658665 0.001827783728735 NA NA NA hsa-let-7f-1-3p TIMP3 0.110713086694053 0.21484524300518 -0.245539739799964 0.00694219454447029 mirMAP -0.158780358487463 1.50887056040504e-05 NA NA NA hsa-miR-103a-3p TIMP3 -0.147443193527362 0.128400914654149 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate;miRTarBase -0.218821229971053 0.000107876344842206 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106a-5p TIMP3 0.110074064773897 0.13045815990621 -0.245539739799964 0.00694219454447029 miRNATAP -0.151550403141731 0.00157925085820405 NA NA NA hsa-miR-106b-5p TIMP3 0.167096183547615 0.0497544396383451 -0.245539739799964 0.00694219454447029 miRNATAP -0.151585111574018 0.000538284746792437 NA NA NA hsa-miR-124-3p TIMP3 -0.506026514549291 0.0078056370358648 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate -0.117152695404692 6.41962133752138e-12 NA NA NA hsa-miR-139-5p TIMP3 -0.647754756897633 2.15378307237163e-06 -0.245539739799964 0.00694219454447029 miRanda -0.104736141481861 2.20604549708984e-05 NA NA NA hsa-miR-16-1-3p TIMP3 0.346674816118499 1.86447850167636e-05 -0.245539739799964 0.00694219454447029 mirMAP -0.134225202346978 0.00101703941446811 NA NA NA hsa-miR-16-5p TIMP3 0.246024668671282 0.00346042804503716 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate -0.259927805493433 1.33428187423219e-08 NA NA NA hsa-miR-181b-5p TIMP3 0.0260899284211646 0.768941836912518 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.221083943243193 1.62594344527416e-06 27383203 Moreover miR-181b was found to directly target the 3' untranslated region 3'UTR of Timp3 mRNA affecting TGF-β-induced EMT gastric cancer hsa-miR-221-3p TIMP3 -0.0109507285071775 0.936440693394519 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.138916337179813 6.80339035687033e-09 27077469 MiR 221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma; The results indicated that miR-221 exacerbated PTC by downregulating the expression of TIMP3; The effects of miR-221 and TIMP3 in vivo were also confirmed by human PTC-bearing mice models which suggest consistent results with those in vitro studies thyroid cancer hsa-miR-222-3p TIMP3 0.107117065575197 0.423818119725697 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.13566281744179 2.17510538858843e-08 NA NA NA hsa-miR-30d-5p TIMP3 -0.0607010868720046 0.471410043548794 -0.245539739799964 0.00694219454447029 miRNATAP -0.170458597349646 0.00407737169887711 NA NA NA hsa-miR-330-3p TIMP3 -0.427388106938151 0.00300489284414266 -0.245539739799964 0.00694219454447029 mirMAP -0.10020300269792 9.30318781840721e-06 NA NA NA hsa-miR-335-5p TIMP3 0.0938511632756978 0.336889056387694 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate -0.138163000478696 5.53969660226331e-05 NA NA NA hsa-miR-362-3p TIMP3 0.032375035235532 0.736465332563774 -0.245539739799964 0.00694219454447029 miRanda -0.102017862208832 0.00296031292780209 NA NA NA hsa-miR-423-5p TIMP3 0.0965587900813789 0.148039180704338 -0.245539739799964 0.00694219454447029 miRNAWalker2_validate -0.217239602517673 9.05367431346767e-05 NA NA NA hsa-miR-491-3p TIMP3 -0.523374665885358 1.93479565404951e-05 -0.245539739799964 0.00694219454447029 PITA;miRNATAP -0.102063770036745 0.000128032518509489 NA NA NA hsa-miR-664a-5p TIMP3 0.0825994937558296 0.264421724444089 -0.245539739799964 0.00694219454447029 MirTarget -0.286445800347957 7.44926377200022e-11 NA NA NA hsa-miR-7-1-3p TIMP3 -0.0894475316162393 0.37322359785108 -0.245539739799964 0.00694219454447029 mirMAP -0.192810518437699 3.49858965853513e-09 NA NA NA hsa-miR-129-5p TNC -0.567133990117126 0.00116152215679936 0.555137977153671 5.94265484482517e-05 miRanda -0.149509764155064 9.83486700574452e-06 NA NA NA hsa-miR-137 TNC -0.924849266740909 1.546832202049e-06 0.555137977153671 5.94265484482517e-05 PITA;miRanda -0.164545713441763 2.43213075870192e-08 NA NA NA hsa-miR-218-5p TNC -0.534287404275829 0.00308322441944796 0.555137977153671 5.94265484482517e-05 MirTarget;miRNATAP -0.142788202398406 7.00144043531709e-06 NA NA NA hsa-miR-19b-3p TNFAIP3 -0.0138427450847924 0.856506310673067 0.335074738135618 5.6352090557097e-05 miRNATAP -0.152758393702604 0.00424126609465948 NA NA NA hsa-miR-767-5p TNFAIP3 -0.551653504513145 2.61109058244854e-05 0.335074738135618 5.6352090557097e-05 miRNATAP -0.16102306301639 3.49474212345195e-09 NA NA NA hsa-miR-181a-5p TNFRSF11B -0.178215604431845 0.0700010802255601 1.26162757466272 7.44220541760494e-14 miRNATAP -0.277027027713611 0.00884657602058699 NA NA NA hsa-miR-338-3p TNFRSF11B -0.39963704679384 0.0034410643220691 1.26162757466272 7.44220541760494e-14 miRanda -0.191014167054792 0.00169474493279753 NA NA NA hsa-miR-124-3p TNFRSF12A -0.506026514549291 0.0078056370358648 1.26480389832477 1.00952790056832e-16 miRNAWalker2_validate -0.232847443231974 6.23109678920406e-11 NA NA NA hsa-miR-346 TNFRSF12A -0.577786425963268 2.10883270131593e-09 1.26480389832477 1.00952790056832e-16 miRanda -0.566204020388786 1.57634019231495e-16 NA NA NA hsa-miR-491-5p TPM2 -0.749881113074983 8.22859263179194e-09 0.13363451500087 0.139749805651159 miRanda -0.120128264446922 2.57861424313645e-05 NA NA NA hsa-miR-497-5p TPM2 -0.000783764887886562 0.991703566618871 0.13363451500087 0.139749805651159 MirTarget -0.144102844071564 0.00808640290270979 NA NA NA hsa-miR-138-5p TPM4 -0.616087649920851 1.35200027885729e-05 0.4360471469222 1.13662915419078e-11 miRNATAP -0.11462005211408 6.87512386989392e-13 NA NA NA hsa-let-7b-3p VCAM1 -0.00495618733298731 0.952288980686967 0.199969614146402 0.256903465114583 MirTarget -0.298812325323089 0.00192359674619391 NA NA NA hsa-miR-126-3p VCAM1 0.283844173647452 0.0045313860754322 0.199969614146402 0.256903465114583 miRNAWalker2_validate;miRTarBase -0.679978731656357 1.97728077941075e-15 25277191;24975661 Osteoblast derived WNT induced secreted protein 1 increases VCAM 1 expression and enhances prostate cancer metastasis by down regulating miR 126;We also observed that naringin enhancing miR-126 expression and miR-126 inhibitor reversed the naringin-inhibited cell motility and VCAM-1 expression; Therefore naringin inhibits migration and invasion of human chondrosarcoma via down-regulation of VCAM-1 by increasing miR-126 metastasis;motility prostate cancer;sarcoma hsa-miR-346 VCAM1 -0.577786425963268 2.10883270131593e-09 0.199969614146402 0.256903465114583 miRanda -0.341273784778134 1.26058804413603e-05 NA NA NA hsa-miR-490-3p VCAM1 -0.834268051506884 5.26203010743215e-06 0.199969614146402 0.256903465114583 miRanda -0.163847798292313 8.966420072783e-05 NA NA NA hsa-let-7f-1-3p VCAN 0.110713086694053 0.21484524300518 -0.0974015294136077 0.346760313972174 MirTarget -0.267262273772779 5.54422291536945e-10 NA NA NA hsa-miR-103a-3p VCAN -0.147443193527362 0.128400914654149 -0.0974015294136077 0.346760313972174 MirTarget;miRNATAP -0.553890369007018 1.98466018419762e-17 NA NA NA hsa-miR-107 VCAN -0.121070851008387 0.198381281894242 -0.0974015294136077 0.346760313972174 MirTarget;miRanda;miRNATAP -0.335253468745814 5.60730376053946e-15 NA NA NA hsa-miR-1179 VCAN -0.117056451908751 0.310989525634765 -0.0974015294136077 0.346760313972174 MirTarget;miRNATAP -0.299186227533311 4.46655183552332e-19 NA NA NA hsa-miR-124-3p VCAN -0.506026514549291 0.0078056370358648 -0.0974015294136077 0.346760313972174 MirTarget;miRNATAP -0.140339534786987 3.74384057942516e-12 NA NA NA hsa-miR-126-5p VCAN 0.177332403948664 0.0711675116243123 -0.0974015294136077 0.346760313972174 mirMAP -0.275539419413907 1.66053744510136e-11 NA NA NA hsa-miR-136-5p VCAN -0.0792119620142504 0.581591369035763 -0.0974015294136077 0.346760313972174 miRNATAP -0.196203655985889 3.0388675351291e-13 NA NA NA hsa-miR-140-5p VCAN 0.065063507103468 0.380452509211773 -0.0974015294136077 0.346760313972174 miRanda -0.306056068126796 6.55595981302352e-08 NA NA NA hsa-miR-141-3p VCAN 0.41120561991992 0.000393344390969055 -0.0974015294136077 0.346760313972174 MirTarget;TargetScan;miRNATAP -0.21269399457041 2.78806878514254e-10 NA NA NA hsa-miR-16-2-3p VCAN 0.468816222075619 7.04377763166292e-05 -0.0974015294136077 0.346760313972174 mirMAP -0.188248989961289 5.9590842021301e-09 NA NA NA hsa-miR-181b-5p VCAN 0.0260899284211646 0.768941836912518 -0.0974015294136077 0.346760313972174 MirTarget;miRNATAP -0.259696726618755 2.02393730383308e-06 NA NA NA hsa-miR-203a-3p VCAN -0.393041310603753 0.0191851699904077 -0.0974015294136077 0.346760313972174 MirTarget -0.183288842783975 4.34408180099296e-16 NA NA NA hsa-miR-217 VCAN 0.540279882451941 0.00312206944061206 -0.0974015294136077 0.346760313972174 miRanda -0.117314232122767 2.49909726818315e-08 NA NA NA hsa-miR-23b-3p VCAN 0.0476610245860094 0.630277683372344 -0.0974015294136077 0.346760313972174 MirTarget;miRNATAP -0.273068241252469 3.65057321161714e-10 NA NA NA hsa-miR-28-5p VCAN 0.104003572105781 0.153594705579534 -0.0974015294136077 0.346760313972174 miRanda -0.202428504867883 0.000450739736653305 NA NA NA hsa-miR-323b-3p VCAN -0.254474308066903 0.15651329633719 -0.0974015294136077 0.346760313972174 miRNATAP -0.118347324284398 3.80473254280117e-08 NA NA NA hsa-miR-335-3p VCAN 0.34540584335595 0.00043848660222294 -0.0974015294136077 0.346760313972174 MirTarget -0.144764391621942 0.000425715223946625 NA NA NA hsa-miR-33a-3p VCAN -0.158366376619191 0.0991512910387226 -0.0974015294136077 0.346760313972174 mirMAP -0.148373330220664 0.00027429544450095 NA NA NA hsa-miR-33a-5p VCAN 0.0197996465877179 0.86830656038963 -0.0974015294136077 0.346760313972174 MirTarget -0.146654698326703 7.04074664713844e-06 NA NA NA hsa-miR-346 VCAN -0.577786425963268 2.10883270131593e-09 -0.0974015294136077 0.346760313972174 miRanda -0.163317891376623 4.42208507977066e-05 NA NA NA hsa-miR-361-3p VCAN -0.0798653643614555 0.271064714084553 -0.0974015294136077 0.346760313972174 miRNATAP -0.671319925428472 1.04940661403362e-30 NA NA NA hsa-miR-455-5p VCAN 0.332224239762 0.0106491358056238 -0.0974015294136077 0.346760313972174 miRanda;miRNATAP -0.140634097025844 2.41674148095597e-06 NA NA NA hsa-miR-485-3p VCAN -0.530677478972593 0.00148549219838911 -0.0974015294136077 0.346760313972174 MirTarget;miRNATAP -0.160493181317393 1.76073675211055e-12 NA NA NA hsa-miR-490-3p VCAN -0.834268051506884 5.26203010743215e-06 -0.0974015294136077 0.346760313972174 miRanda -0.117295751937622 3.27188948380318e-08 NA NA NA hsa-miR-495-3p VCAN -0.421982588962504 0.00504424038526901 -0.0974015294136077 0.346760313972174 mirMAP -0.201760852611093 1.57134053418871e-15 NA NA NA hsa-miR-539-5p VCAN -0.326485413953598 0.0554453076411246 -0.0974015294136077 0.346760313972174 mirMAP -0.175999303538679 2.39933395878893e-15 NA NA NA hsa-miR-543 VCAN -0.347737549779625 0.0157394585079683 -0.0974015294136077 0.346760313972174 miRanda;miRNATAP -0.216812135514305 8.82345198921677e-16 NA NA NA hsa-miR-590-3p VCAN 0.312951515438396 0.000480455423843996 -0.0974015294136077 0.346760313972174 miRanda -0.157064727573625 0.000298879457462969 NA NA NA hsa-miR-628-5p VCAN -0.0469793532265896 0.657420003383685 -0.0974015294136077 0.346760313972174 MirTarget;miRNATAP -0.193523355778825 2.17642198534958e-07 NA NA NA hsa-miR-664a-3p VCAN 0.0413918462467198 0.611334357897022 -0.0974015294136077 0.346760313972174 mirMAP -0.514000548951452 4.38210834509896e-28 NA NA NA hsa-miR-101-3p VEGFA -0.132333931567244 0.241891922291381 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.179012476724308 0.000221850261733319 NA NA NA hsa-miR-1224-5p VEGFA -0.53941068839383 0.00201058335769201 0.545202702414815 3.65580722751043e-08 MirTarget -0.12693052777853 1.1909229874546e-07 NA NA NA hsa-miR-129-5p VEGFA -0.567133990117126 0.00116152215679936 0.545202702414815 3.65580722751043e-08 miRanda -0.178350435603243 1.58281485759764e-13 NA NA NA hsa-miR-26b-3p VEGFA -0.0542537787460029 0.4802214385739 0.545202702414815 3.65580722751043e-08 MirTarget -0.151139595719221 0.00815352929658283 NA NA NA hsa-miR-29a-3p VEGFA -0.224140851576083 0.0349516103550236 0.545202702414815 3.65580722751043e-08 MirTarget -0.188400523607611 0.000280773283001581 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.26834261955727 0.00453760540520233 0.545202702414815 3.65580722751043e-08 MirTarget -0.238273224497899 1.35712590368669e-07 NA NA NA hsa-miR-29b-3p VEGFA -0.178522712044497 0.0856106432165465 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.174785884873336 0.000121514677714241 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.372180390387259 0.00202634431973208 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;MirTarget -0.163350888739243 2.07703033697715e-05 NA NA NA hsa-miR-330-3p VEGFA -0.427388106938151 0.00300489284414266 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.14940180557451 2.38610841931945e-07 NA NA NA hsa-miR-342-3p VEGFA -0.125683829770877 0.105810751640137 0.545202702414815 3.65580722751043e-08 miRanda;miRNATAP -0.183375082823802 0.00268020639799555 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA -0.210113949579608 0.0056866083818614 0.545202702414815 3.65580722751043e-08 MirTarget -0.259691752964477 3.6506936798186e-05 NA NA NA hsa-miR-383-5p VEGFA -0.850440167826561 1.6745326125383e-07 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.171548247272876 2.39831482676198e-11 NA NA NA hsa-miR-497-5p VEGFA -0.000783764887886562 0.991703566618871 0.545202702414815 3.65580722751043e-08 MirTarget -0.217975385158274 0.000295143152499975 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-504-5p VEGFA -0.510726779625117 6.12122269907368e-05 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase -0.212758235683993 1.16548576784258e-10 NA NA NA hsa-miR-9-5p VEGFA -0.125377971246422 0.269896477802284 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.372852027573008 5.51606960459938e-05 NA NA NA hsa-miR-124-3p VIM -0.506026514549291 0.0078056370358648 0.723805060907852 7.98331283128393e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.242482268690043 9.84572263179531e-15 27251409 In in-vitro study overexpression of miR-124 in A549 cells suppressed cell migration and invasion activity decreased expression of vimentin but increased expression of E-cadherin and induced apoptosis cell migration lung cancer hsa-miR-129-5p VIM -0.567133990117126 0.00116152215679936 0.723805060907852 7.98331283128393e-07 miRNATAP -0.171900495182114 1.11784970016168e-06 NA NA NA hsa-miR-137 VIM -0.924849266740909 1.546832202049e-06 0.723805060907852 7.98331283128393e-07 miRanda -0.248757863662315 2.37562539593103e-16 NA NA NA hsa-miR-138-5p VIM -0.616087649920851 1.35200027885729e-05 0.723805060907852 7.98331283128393e-07 miRNAWalker2_validate -0.321195743073257 2.27700846705118e-14 26796277;27049260 miR-138 overexpression also down-regulated vimentin expression and upregulated E-cadherin expression suggesting that miR-138 inhibited EMT;In addition the epithelial-mesenchymal transition EMT related markers E-cadherin or vimentin was up-regulated or down-regulated upon the overexpression of miR-138 in NSCLC cells ; breast cancer;lung squamous cell cancer hsa-miR-3607-3p VIM -0.0118040987013632 0.907228689257085 0.723805060907852 7.98331283128393e-07 MirTarget -0.277266797368936 4.35999460000282e-06 NA NA NA hsa-miR-488-3p VIM -0.257955761012568 0.00280795162806256 0.723805060907852 7.98331283128393e-07 miRNATAP -0.236317113109091 0.00102970851289541 NA NA NA hsa-miR-496 VIM -0.139833482232877 0.39597541862532 0.723805060907852 7.98331283128393e-07 miRanda -0.100610319524474 0.00721644298907212 NA NA NA hsa-miR-9-5p VIM -0.125377971246422 0.269896477802284 0.723805060907852 7.98331283128393e-07 miRNAWalker2_validate -0.950423158993112 3.74889652109913e-13 25086633 Expression of miR-9 was also higher in tumors showing the CD44+/CD24- phenotype vimentin expression and E-cadherin loss breast cancer hsa-miR-153-3p WIPF1 -0.173449510253619 0.0654368045743418 0.0773901926389398 0.213173772720565 MirTarget -0.153273993870522 8.66702148548809e-10 NA NA NA hsa-miR-582-3p WIPF1 -0.11807589183011 0.304077332003677 0.0773901926389398 0.213173772720565 PITA -0.149398082247163 7.3898899378134e-14 NA NA NA hsa-miR-7-1-3p WIPF1 -0.0894475316162393 0.37322359785108 0.0773901926389398 0.213173772720565 MirTarget;mirMAP -0.109034414180039 1.77081399150635e-06 NA NA NA hsa-miR-126-5p WNT5A 0.177332403948664 0.0711675116243123 0.401727178109578 0.000135878679478885 mirMAP -0.197498035605205 2.92702569263705e-05 NA NA NA hsa-miR-127-5p WNT5A -0.128719168376827 0.401210814502785 0.401727178109578 0.000135878679478885 PITA;miRNATAP -0.148503710600712 5.58056138975753e-07 NA NA NA hsa-miR-129-5p WNT5A -0.567133990117126 0.00116152215679936 0.401727178109578 0.000135878679478885 PITA;miRanda;miRNATAP -0.122949419919608 1.9178703847978e-06 NA NA NA hsa-miR-140-3p WNT5A -0.123864258867705 0.14796686619449 0.401727178109578 0.000135878679478885 MirTarget;miRNATAP -0.304640564073949 8.7015213884132e-06 NA NA NA hsa-miR-154-5p WNT5A -0.226468848904462 0.107380908211261 0.401727178109578 0.000135878679478885 mirMAP;miRNATAP -0.133746849078689 2.20811690518715e-05 NA NA NA hsa-miR-182-5p WNT5A -0.146726537592027 0.389265298808118 0.401727178109578 0.000135878679478885 MirTarget -0.17706315884905 4.76584976388537e-11 NA NA NA hsa-miR-326 WNT5A -0.631050656251074 8.83643450601471e-05 0.401727178109578 0.000135878679478885 miRanda -0.121863379344651 7.54927535246161e-06 NA NA NA hsa-miR-330-5p WNT5A -0.262932095995605 0.0465226565966658 0.401727178109578 0.000135878679478885 miRanda -0.182269668340434 4.68881013813934e-08 NA NA NA hsa-miR-3607-3p WNT5A -0.0118040987013632 0.907228689257085 0.401727178109578 0.000135878679478885 mirMAP -0.158859120300375 0.00033593635970035 NA NA NA hsa-miR-369-3p WNT5A -0.153496605399658 0.296055925448078 0.401727178109578 0.000135878679478885 miRNATAP -0.109058905963049 0.000320216606169546 NA NA NA hsa-miR-409-3p WNT5A 0.00456692516634361 0.974143243758506 0.401727178109578 0.000135878679478885 mirMAP -0.110008292104967 0.000487794597719254 NA NA NA hsa-miR-491-3p WNT5A -0.523374665885358 1.93479565404951e-05 0.401727178109578 0.000135878679478885 mirMAP -0.148527988707063 3.61608334059833e-05 NA NA NA hsa-miR-539-5p WNT5A -0.326485413953598 0.0554453076411246 0.401727178109578 0.000135878679478885 mirMAP -0.161017969407705 3.21999166239326e-10 NA NA NA hsa-miR-582-5p WNT5A -0.215764335500665 0.0760892640434509 0.401727178109578 0.000135878679478885 miRNATAP -0.328837370224082 5.30150255364318e-21 NA NA NA hsa-miR-7-1-3p WNT5A -0.0894475316162393 0.37322359785108 0.401727178109578 0.000135878679478885 mirMAP -0.23358023082722 1.29867246418668e-07 NA NA NA hsa-miR-767-5p WNT5A -0.551653504513145 2.61109058244854e-05 0.401727178109578 0.000135878679478885 PITA;miRNATAP -0.21156019312404 4.27965570737888e-10 NA NA NA hsa-miR-885-5p WNT5A -0.423614695846868 1.14213289528402e-05 0.401727178109578 0.000135878679478885 MirTarget;PITA -0.286582466253295 6.75804778438008e-10 NA NA NA