miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7e-5p AIFM1 0.227253058773149 0.162290058199053 -0.0424967598873502 0.71464466747368 miRNATAP -0.186716167734706 1.73819478721118e-05 NA NA NA hsa-miR-125a-5p AIFM1 -0.261743402170195 0.116107665196876 -0.0424967598873502 0.71464466747368 miRanda -0.121359237105245 0.0045694506339796 NA NA NA hsa-miR-125b-5p AIFM1 -0.176364454911029 0.43771853581292 -0.0424967598873502 0.71464466747368 miRNATAP -0.213166636344151 1.12712511143767e-12 NA NA NA hsa-miR-145-5p AIFM1 -1.54503595327403 2.65080161523141e-09 -0.0424967598873502 0.71464466747368 miRNATAP -0.0909344960853798 0.000537860247613544 20332243 Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death prostate cancer hsa-miR-199a-5p AIFM1 0.723739336873244 5.69674696426761e-05 -0.0424967598873502 0.71464466747368 miRanda -0.212703838928823 2.57994055785662e-08 NA NA NA hsa-let-7a-5p AKT2 0.298659498236324 0.00963231738125113 -0.163157777800721 0.0933816097673111 TargetScan -0.121773636908232 0.0205827447176555 NA NA NA hsa-miR-200b-3p AKT2 2.06025765178663 3.07718049337497e-10 -0.163157777800721 0.0933816097673111 TargetScan -0.0725710558336877 2.55193148650066e-05 NA NA NA hsa-miR-21-5p AKT2 2.21515015440792 6.0468197386674e-49 -0.163157777800721 0.0933816097673111 miRNAWalker2_validate -0.125319232582453 0.000121164702766457 NA NA NA hsa-miR-22-3p AKT2 0.530940324058038 8.6675746679475e-07 -0.163157777800721 0.0933816097673111 mirMAP -0.142765168845465 0.0100550488787565 NA NA NA hsa-miR-3065-3p AKT2 -0.00685158653722073 0.979081293235379 -0.163157777800721 0.0933816097673111 MirTarget;miRNATAP -0.0885761367279873 8.25497420974249e-05 NA NA NA hsa-miR-338-3p AKT2 -0.0138760121093551 0.956163634155272 -0.163157777800721 0.0933816097673111 mirMAP -0.119124406302102 2.38431138421264e-07 NA NA NA hsa-miR-502-5p AKT2 0.873538712251823 0.0012275719769761 -0.163157777800721 0.0933816097673111 mirMAP -0.0721101202043286 0.00441326137208947 NA NA NA hsa-miR-671-5p AKT2 1.6497630797889 2.89172004241043e-12 -0.163157777800721 0.0933816097673111 miRNATAP -0.0537192439327676 0.025531768421564 NA NA NA hsa-miR-106a-5p AKT3 0.587427028487119 0.00838999163993323 -0.273001052722672 0.188651193580836 miRNATAP -0.2388542477399 2.17572670318915e-05 NA NA NA hsa-miR-106b-5p AKT3 1.08518388423396 4.82746923373852e-09 -0.273001052722672 0.188651193580836 miRNATAP -0.63116532758866 4.23753205402999e-25 NA NA NA hsa-miR-107 AKT3 0.85152957824299 1.22369651446858e-11 -0.273001052722672 0.188651193580836 PITA;miRanda -0.756112102935537 7.89013248827764e-16 NA NA NA hsa-miR-140-5p AKT3 0.132398579631585 0.457960134430787 -0.273001052722672 0.188651193580836 miRanda -0.347730244309107 8.60477835366952e-07 NA NA NA hsa-miR-142-3p AKT3 1.80134804047727 3.87649742898476e-07 -0.273001052722672 0.188651193580836 miRanda -0.243960154172525 2.78669142941441e-13 NA NA NA hsa-miR-146b-5p AKT3 2.23105707690238 3.83997814011313e-23 -0.273001052722672 0.188651193580836 miRNAWalker2_validate -0.255166569260379 5.2556904982786e-07 NA NA NA hsa-miR-15a-5p AKT3 1.07800995489566 4.32072598796529e-10 -0.273001052722672 0.188651193580836 miRNAWalker2_validate;miRTarBase;miRNATAP -0.604304838648006 1.49448472656197e-19 NA NA NA hsa-miR-15b-5p AKT3 0.637819606405168 0.000580041575431604 -0.273001052722672 0.188651193580836 miRNATAP -0.67973843202396 2.01070149868433e-28 NA NA NA hsa-miR-16-5p AKT3 0.468459442059375 0.02635007201346 -0.273001052722672 0.188651193580836 miRNAWalker2_validate;miRTarBase;miRNATAP -0.568045037958797 4.87003529234726e-25 NA NA NA hsa-miR-17-3p AKT3 1.37838995268509 5.00444740462873e-13 -0.273001052722672 0.188651193580836 miRNATAP -0.477549087236799 3.52641498743937e-15 NA NA NA hsa-miR-17-5p AKT3 1.57209612312313 5.10453838016207e-11 -0.273001052722672 0.188651193580836 TargetScan;miRNATAP -0.465520585359035 3.92511879234349e-23 NA NA NA hsa-miR-181a-5p AKT3 1.39352013383959 4.74824377258519e-17 -0.273001052722672 0.188651193580836 miRNATAP -0.296440897727793 3.58933749648964e-05 NA NA NA hsa-miR-181b-5p AKT3 1.44365471425231 6.03807007335243e-15 -0.273001052722672 0.188651193580836 miRNATAP -0.30554924094169 2.11059007168117e-06 NA NA NA hsa-miR-20a-5p AKT3 1.57190995476158 8.72275528729458e-12 -0.273001052722672 0.188651193580836 miRNATAP -0.399852243068736 1.83576734204372e-15 NA NA NA hsa-miR-22-3p AKT3 0.530940324058038 8.6675746679475e-07 -0.273001052722672 0.188651193580836 miRNATAP -0.243446737560933 0.0413079544237688 NA NA NA hsa-miR-29a-3p AKT3 -0.235052170104117 0.138527567930958 -0.273001052722672 0.188651193580836 miRNATAP -0.481734004083601 8.99237467028005e-10 NA NA NA hsa-miR-29b-2-5p AKT3 -0.39718520927539 0.0233851474877787 -0.273001052722672 0.188651193580836 mirMAP -0.18854298003376 0.00966484577986954 NA NA NA hsa-miR-29b-3p AKT3 0.0225365195743876 0.914313337784307 -0.273001052722672 0.188651193580836 miRNATAP -0.512613147987846 2.1060849979224e-19 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-320a AKT3 0.451741078692272 0.00893327237386749 -0.273001052722672 0.188651193580836 PITA;miRanda;miRNATAP -0.227893659314064 0.00195741110005248 NA NA NA hsa-miR-320b AKT3 1.21733873788625 7.99882585998487e-07 -0.273001052722672 0.188651193580836 PITA;miRanda;miRNATAP -0.349946231431661 4.55044321819242e-13 NA NA NA hsa-miR-335-3p AKT3 2.29463721765513 4.1956113745077e-18 -0.273001052722672 0.188651193580836 mirMAP -0.30313372364369 2.03502007738655e-12 NA NA NA hsa-miR-33a-3p AKT3 0.21453033253985 0.371591474252951 -0.273001052722672 0.188651193580836 mirMAP -0.472983796155366 5.05969351316599e-20 NA NA NA hsa-miR-340-5p AKT3 0.344103676703511 0.0160638942614091 -0.273001052722672 0.188651193580836 mirMAP -0.247728416119388 0.0058369886677658 NA NA NA hsa-miR-362-3p AKT3 0.994614346444282 4.39793878186399e-05 -0.273001052722672 0.188651193580836 miRanda -0.431690312253611 6.06358027466994e-18 NA NA NA hsa-miR-362-5p AKT3 1.45312548529729 9.37098891085093e-09 -0.273001052722672 0.188651193580836 PITA;TargetScan;miRNATAP -0.314823022647034 2.2336023315157e-11 NA NA NA hsa-miR-369-3p AKT3 0.644921905467686 0.00104986428608648 -0.273001052722672 0.188651193580836 mirMAP -0.258474022492291 5.39025552593403e-05 NA NA NA hsa-miR-374a-5p AKT3 0.239597788731458 0.0202963000797544 -0.273001052722672 0.188651193580836 mirMAP -0.412183820224296 0.00115229496586381 NA NA NA hsa-miR-409-3p AKT3 1.02296003511803 1.54748197930307e-08 -0.273001052722672 0.188651193580836 PITA;mirMAP -0.163474825992855 0.0175312737806419 NA NA NA hsa-miR-421 AKT3 1.26653675546617 2.35180826009926e-08 -0.273001052722672 0.188651193580836 miRanda;mirMAP -0.314340685542377 4.9943728259466e-09 NA NA NA hsa-miR-424-5p AKT3 0.956135912596328 0.00035164943928494 -0.273001052722672 0.188651193580836 miRNATAP -0.335493140663715 7.54630340718379e-14 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 1.88467797720099 9.65178855450719e-15 -0.273001052722672 0.188651193580836 miRNATAP -0.450105998191059 5.87603301592361e-23 NA NA NA hsa-miR-502-3p AKT3 0.989057260587538 3.37032335853725e-07 -0.273001052722672 0.188651193580836 miRNATAP -0.584189726633833 5.98074147538183e-23 NA NA NA hsa-miR-502-5p AKT3 0.873538712251823 0.0012275719769761 -0.273001052722672 0.188651193580836 PITA;miRNATAP -0.352513250404314 1.89754896008479e-11 NA NA NA hsa-miR-505-3p AKT3 0.68973424635459 0.00225185811813183 -0.273001052722672 0.188651193580836 mirMAP -0.427036086270006 8.10939959640155e-16 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-539-5p AKT3 0.455406484803261 0.10846447950775 -0.273001052722672 0.188651193580836 mirMAP;miRNATAP -0.1387220122356 0.00223160583874989 NA NA NA hsa-miR-542-3p AKT3 1.12416854979951 1.02649534578738e-12 -0.273001052722672 0.188651193580836 miRanda -0.281961851589184 0.00026441191767321 NA NA NA hsa-miR-577 AKT3 0.615893340074725 0.210494450869356 -0.273001052722672 0.188651193580836 mirMAP -0.207115000396204 9.2562926093692e-15 NA NA NA hsa-miR-769-5p AKT3 0.933922223076232 1.9485893796755e-09 -0.273001052722672 0.188651193580836 PITA;miRNATAP -0.434363941162121 2.76713270484797e-08 NA NA NA hsa-miR-93-5p AKT3 1.68243825551104 4.62947431501061e-15 -0.273001052722672 0.188651193580836 miRNATAP -0.424661897302067 1.5335508992555e-15 NA NA NA hsa-miR-139-5p APAF1 -1.41674256628297 4.51005988644234e-14 0.587802161974679 1.40249037305525e-07 mirMAP -0.18599851704341 8.66634983585649e-08 NA NA NA hsa-miR-195-3p APAF1 -0.694544351365025 0.000214711021317786 0.587802161974679 1.40249037305525e-07 mirMAP -0.154023107037798 2.64192546751675e-05 NA NA NA hsa-miR-23b-3p APAF1 -0.228571473429 0.0553601132069074 0.587802161974679 1.40249037305525e-07 miRNATAP -0.269065646303629 5.2350120969382e-06 NA NA NA hsa-miR-27b-3p APAF1 -0.439806942644624 0.000523870009254693 0.587802161974679 1.40249037305525e-07 miRNATAP -0.265092538474567 1.29391788804069e-06 NA NA NA hsa-miR-374b-5p APAF1 0.00249900187478502 0.985380083859555 0.587802161974679 1.40249037305525e-07 mirMAP -0.126854994081879 0.015044272795016 NA NA NA hsa-miR-101-5p ATM -0.368786665738683 0.0435281632867238 0.177849811817311 0.2156767159682 miRNAWalker2_validate -0.0990121511833236 0.0409814212525405 22014955 Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299 H1975 and A549 cells it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells lung squamous cell cancer hsa-miR-125a-3p ATM 0.0862037949225951 0.688453004025032 0.177849811817311 0.2156767159682 miRanda -0.1628669430806 7.62120337537398e-05 NA NA NA hsa-miR-186-5p ATM 0.35512789129261 0.0196931838168008 0.177849811817311 0.2156767159682 mirMAP -0.236055566978731 4.14521339122904e-05 NA NA NA hsa-miR-18a-5p ATM 2.04701000113742 1.30593450319289e-12 0.177849811817311 0.2156767159682 miRNAWalker2_validate;miRTarBase;MirTarget -0.106088412949694 0.000233162954700209 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 0.936987029203338 9.28141970787798e-06 0.177849811817311 0.2156767159682 miRNAWalker2_validate -0.101416375959996 0.0132830020347779 NA NA NA hsa-miR-203a-3p ATM 0.986535065247669 0.00954714606545506 0.177849811817311 0.2156767159682 MirTarget -0.115403296072754 2.66140590690965e-07 27542403;24145123 MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression;miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM metastasis;drug resistance gastric cancer;colorectal cancer hsa-miR-26a-2-3p ATM 0.0619487388777404 0.765401751442771 0.177849811817311 0.2156767159682 MirTarget -0.0950886060564285 0.0277443639119359 NA NA NA hsa-miR-26a-5p ATM -0.507487084157331 3.23715933371269e-05 0.177849811817311 0.2156767159682 MirTarget -0.260172318657783 0.000304699607416999 24211747 MiR 26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia telangiectasia mutated; Mechanistically this effect is mediated by direct targeting of miR-26a to the 3'UTR of ATM which leads to reduced ATM levels and consequent inhibition of the homologous recombination repair pathway glioblastoma hsa-miR-26b-5p ATM -0.499493687076043 0.0118149973400486 0.177849811817311 0.2156767159682 MirTarget -0.28829637184455 1.3577512320118e-11 NA NA NA hsa-miR-27a-5p ATM 0.59763448976729 0.00736257811879899 0.177849811817311 0.2156767159682 MirTarget -0.128937108789717 0.000963441669595833 NA NA NA hsa-miR-29a-5p ATM 1.00715634051951 4.47499137997344e-07 0.177849811817311 0.2156767159682 mirMAP -0.158446181487041 0.000220888265045783 NA NA NA hsa-miR-30b-5p ATM -0.0106833209203501 0.954966272944722 0.177849811817311 0.2156767159682 mirMAP -0.202472417717984 1.15268236662823e-05 25202329 However specific miRNAs are downregulated in ATC such as those of the miR-200 and miR-30 families which are important negative regulators of cell migration invasion and epithelial-to-mesenchymal transition EMT processes that are overactivated in ATC cell migration thyroid cancer hsa-miR-30d-3p ATM 0.0608340295673737 0.708110230223927 0.177849811817311 0.2156767159682 mirMAP -0.139639670010025 0.010596842202583 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC drug resistance;poor survival thyroid cancer hsa-miR-30e-3p ATM -0.444998679251398 0.000501880465265124 0.177849811817311 0.2156767159682 mirMAP -0.2787303955117 4.99920516333649e-05 NA NA NA hsa-miR-324-5p ATM 0.800946351685734 0.00101337664367375 0.177849811817311 0.2156767159682 miRanda -0.194410763089921 2.54762832233874e-08 NA NA NA hsa-miR-335-3p ATM 2.29463721765513 4.1956113745077e-18 0.177849811817311 0.2156767159682 mirMAP -0.0821107480912928 0.00800325441885129 NA NA NA hsa-miR-339-5p ATM 0.51232205151031 0.0560469213103598 0.177849811817311 0.2156767159682 miRanda -0.13426109192386 3.23996774413599e-05 NA NA NA hsa-miR-3607-3p ATM 0.479939234340415 0.251616873367277 0.177849811817311 0.2156767159682 mirMAP -0.118388838063909 1.81323627835821e-08 NA NA NA hsa-miR-362-3p ATM 0.994614346444282 4.39793878186399e-05 0.177849811817311 0.2156767159682 miRanda -0.109504548916553 0.00284068743345207 NA NA NA hsa-miR-374b-5p ATM 0.00249900187478502 0.985380083859555 0.177849811817311 0.2156767159682 mirMAP -0.144285689908357 0.0280946268775611 NA NA NA hsa-miR-409-3p ATM 1.02296003511803 1.54748197930307e-08 0.177849811817311 0.2156767159682 mirMAP -0.1058888802892 0.0259202803286089 NA NA NA hsa-miR-455-5p ATM 0.644390760445571 0.00262275997170695 0.177849811817311 0.2156767159682 miRanda -0.0948344357403787 0.0202364159782766 NA NA NA hsa-miR-500a-5p ATM 1.33126717816499 3.1497328652235e-07 0.177849811817311 0.2156767159682 mirMAP -0.107353747366416 0.00106465343269018 NA NA NA hsa-miR-576-5p ATM 0.872721964495849 5.20470410008775e-05 0.177849811817311 0.2156767159682 mirMAP -0.179572094249142 6.09724887639175e-06 NA NA NA hsa-miR-577 ATM 0.615893340074725 0.210494450869356 0.177849811817311 0.2156767159682 PITA -0.0814822847956269 2.16480369573049e-05 NA NA NA hsa-miR-590-3p ATM 0.858742926831233 0.000127281269371976 0.177849811817311 0.2156767159682 miRanda;mirMAP -0.191875713899991 4.91581808648856e-07 NA NA NA hsa-miR-590-5p ATM 0.932604531809045 8.39043954167884e-05 0.177849811817311 0.2156767159682 mirMAP -0.193650997523192 6.69095242773379e-08 NA NA NA hsa-miR-766-3p ATM 0.168886051269712 0.412950041105629 0.177849811817311 0.2156767159682 MirTarget -0.121825525421206 0.00429686536815753 NA NA NA hsa-miR-92a-3p ATM 1.06124545165614 6.51550014372282e-08 0.177849811817311 0.2156767159682 miRNAWalker2_validate -0.0896743615644009 0.0407997508789992 NA NA NA hsa-miR-30a-5p BAX -0.742755040631906 3.79943871404435e-05 0.429665750094717 0.000916476834958492 miRNAWalker2_validate -0.113331759009117 0.00988334840078822 NA NA NA hsa-miR-103a-3p BCL2 1.01322687786547 1.60813894223583e-11 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.342379556752644 7.6824626909566e-06 NA NA NA hsa-miR-126-5p BCL2 0.450893496822779 0.0112966412858755 -0.899142762694703 2.93311234351261e-06 mirMAP -0.301105791117778 6.33068273627289e-06 NA NA NA hsa-miR-130b-5p BCL2 1.47709791778827 1.34679413565661e-06 -0.899142762694703 2.93311234351261e-06 mirMAP -0.300247989068655 3.69743919415252e-16 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-136-5p BCL2 0.501768051727903 0.0272130411225693 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.17779316149359 0.000701933942815507 NA NA NA hsa-miR-142-3p BCL2 1.80134804047727 3.87649742898476e-07 -0.899142762694703 2.93311234351261e-06 miRanda -0.0774099523842551 0.0188198682445078 NA NA NA hsa-miR-148a-3p BCL2 -0.18108394434325 0.495345303586758 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.155639676145632 0.000533827688012766 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-15a-5p BCL2 1.07800995489566 4.32072598796529e-10 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.382947945084909 6.12551340620688e-09 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 0.811179945491507 0.000927520880593552 -0.899142762694703 2.93311234351261e-06 mirMAP -0.397701597338993 2.34881009347574e-18 18449891;25594541;26915294;26884837 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression drug resistance;;poor survival; gastric cancer;breast cancer;lung cancer;liver cancer hsa-miR-15b-5p BCL2 0.637819606405168 0.000580041575431604 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.487012003866561 1.64331477205887e-15 18449891;25594541;26915294;26884837 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression drug resistance;;poor survival; gastric cancer;breast cancer;lung cancer;liver cancer hsa-miR-16-1-3p BCL2 1.23864765632542 1.24544799589822e-08 -0.899142762694703 2.93311234351261e-06 mirMAP -0.282734232855026 1.96976466813529e-07 18931683 MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 prostate cancer hsa-miR-16-2-3p BCL2 0.869267463341732 0.000785361809327569 -0.899142762694703 2.93311234351261e-06 mirMAP -0.305851125033161 4.26063951557552e-12 NA NA NA hsa-miR-16-5p BCL2 0.468459442059375 0.02635007201346 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.307544967095245 3.1475788390589e-08 18449891;21336967;24447552;25435430;24598659;18931683;22966344;25623762 miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells drug resistance;;worse prognosis;;;;poor survival;drug resistance gastric cancer;liver cancer;lymphoma;lung cancer;lymphoma;prostate cancer;pancreatic cancer;colon cancer hsa-miR-17-5p BCL2 1.57209612312313 5.10453838016207e-11 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.335214889051797 4.02760065493226e-13 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181a-5p BCL2 1.39352013383959 4.74824377258519e-17 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.258210300397206 0.000141372228195464 24267199;23740615;25524579;27534652;24335172 Bufalin was found to induce the expression of miR-181a a small non-coding RNA believed to induce apoptosis by repressing its target gene BCL-2; In prostate cancer PC-3cell line bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation;The results from Western blotting indicated that miR-181a might be associated with the up-regulation of bcl-2 and matrix metalloproteinase 9 and the down-regulation of tissue inhibitor of metalloproteinases-3 and p21 in MG63 cells;Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression;In addition inhibition of miR-181a promoted apoptosis of HeLa and CaSKi cells due to increasing Bax expression and decreasing Bcl-2 expression;The function role of miR 181a in chemosensitivity to adriamycin by targeting Bcl 2 in low invasive breast cancer cells; Luciferase reporter vector with the putative BCL-2 3' untranslated region 3'UTR was constructed to explore whether BCL-2 was a direct target gene of miR-181a; Real-time PCR was performed to test the expression of miR-181a and Bcl-2 in the selected breast cancer tissue samples; Transfected with miR-181a mimic in cells resulted in the decreased expression of Bcl-2; At least in part the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of miR-181a enhanced adriamycin-induced apoptosis via targeting Bcl-2 ;;;; prostate cancer;sarcoma;lung squamous cell cancer;cervical and endocervical cancer;breast cancer hsa-miR-181b-5p BCL2 1.44365471425231 6.03807007335243e-15 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.301605362768947 6.62371767382316e-07 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-182-5p BCL2 1.73826081735237 5.69817940588551e-09 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.281139475876817 3.62164489087682e-14 23936432;26870290 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR 182 and p21; Bcl2 and p21 were identified to be potential target genes of miR-182 in PC3 cells;The expression levels of B-cell lymphoma-2 Bcl-2 and microRNA-182 miR-182 were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction respectively; Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells; Finally it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182 ; prostate cancer;B cell lymphoma hsa-miR-186-5p BCL2 0.35512789129261 0.0196931838168008 -0.899142762694703 2.93311234351261e-06 mirMAP -0.381047109248084 1.09796348306849e-06 NA NA NA hsa-miR-192-5p BCL2 2.0867723747501 3.57854249239079e-08 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.219076747701746 8.11784107313729e-14 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 4.51951031652328 7.04026169031626e-18 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.135038964160811 5.10281494563971e-11 NA NA NA hsa-miR-200a-5p BCL2 2.19152245759943 3.17968183522514e-11 -0.899142762694703 2.93311234351261e-06 mirMAP -0.27726591358478 2.73221347510694e-17 NA NA NA hsa-miR-200b-3p BCL2 2.06025765178663 3.07718049337497e-10 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.26795392182203 1.0913241181438e-15 NA NA NA hsa-miR-200b-5p BCL2 0.934206940937576 0.00554096871767416 -0.899142762694703 2.93311234351261e-06 mirMAP -0.269850401550945 2.00719148228126e-14 NA NA NA hsa-miR-200c-3p BCL2 1.74925752003763 3.42000026705311e-08 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.320842719761782 4.38895009841552e-21 NA NA NA hsa-miR-20a-3p BCL2 0.703027135708586 0.022464856696655 -0.899142762694703 2.93311234351261e-06 mirMAP -0.243080236722433 3.83821044129985e-10 NA NA NA hsa-miR-20a-5p BCL2 1.57190995476158 8.72275528729458e-12 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.266605223273104 5.09581999167075e-08 NA NA NA hsa-miR-21-5p BCL2 2.21515015440792 6.0468197386674e-49 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.40068246416158 5.43440909882672e-10 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-215-5p BCL2 1.10296552366805 0.0225256935718223 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.109875079706307 5.99327555192393e-06 NA NA NA hsa-miR-224-5p BCL2 1.11923763019015 0.000974728485303372 -0.899142762694703 2.93311234351261e-06 mirMAP -0.200216081669974 3.92630015720796e-09 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 0.939979588719366 2.77281797589097e-05 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.263894680703146 3.54075573905773e-07 NA NA NA hsa-miR-29a-5p BCL2 1.00715634051951 4.47499137997344e-07 -0.899142762694703 2.93311234351261e-06 mirMAP -0.30932038928841 8.74631087986786e-08 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 0.0225365195743876 0.914313337784307 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.198517403350232 0.000523509891552837 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-30d-3p BCL2 0.0608340295673737 0.708110230223927 -0.899142762694703 2.93311234351261e-06 mirMAP -0.252389142623314 0.000684241763487853 NA NA NA hsa-miR-335-3p BCL2 2.29463721765513 4.1956113745077e-18 -0.899142762694703 2.93311234351261e-06 mirMAP -0.268016796875566 5.753163435092e-11 NA NA NA hsa-miR-338-5p BCL2 -0.420442436641152 0.0583175290447746 -0.899142762694703 2.93311234351261e-06 PITA -0.124048509127431 0.022100499664932 NA NA NA hsa-miR-33a-5p BCL2 0.372183130885047 0.335617783855811 -0.899142762694703 2.93311234351261e-06 mirMAP -0.187397433435176 4.13736589904427e-10 NA NA NA hsa-miR-34a-5p BCL2 0.691825068787607 0.00069818668499891 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.329985813813796 6.99247696897484e-09 24988056;18803879;24565525;23155233;24444609;20687223;22623155;19714243;25053345;20433755;21399894;22964582;23862748 Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression ;poor survival;differentiation;drug resistance;;poor survival;drug resistance;;poor survival;drug resistance;;;; gastric cancer;gastric cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer hsa-miR-375 BCL2 -0.348733074320394 0.47719066431766 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate -0.0660235202503528 0.00663885887279 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-409-3p BCL2 1.02296003511803 1.54748197930307e-08 -0.899142762694703 2.93311234351261e-06 mirMAP -0.249306590530499 0.000107202832832321 NA NA NA hsa-miR-429 BCL2 1.58250682050303 4.75828087352234e-05 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.240238418690481 1.24621969812778e-16 26513239;23999873;26511969 MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation ;; gastric cancer;esophageal cancer;glioblastoma hsa-miR-450b-5p BCL2 1.36137774989901 7.45499130609203e-11 -0.899142762694703 2.93311234351261e-06 mirMAP -0.233477398914929 2.03093227176541e-05 NA NA NA hsa-miR-451a BCL2 -1.46088232902498 1.03697404390715e-06 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase -0.0820132061982201 0.0367848775721495 26516138;23053883 Western blot was used for the detection of the protein expression of Bcl-2 and Caspase 3 after the transfection of miR-451 mimics /inhibitors; Bioinformatics analysis demonstrated that Bcl-2 protein is a potential target gene for miR-451; Increased miR-451 expression may negatively regulate Bcl-2 mRNA and protein expression followed by affecting the protein expression of caspase 3 and accelerate the apoptosis in breast cancer indicating that miR-451 might influence the drug resistances of the Paclitaxel-resistant breast cancer cell line;The expression of miR-451 was analyzed by RT-PCR and the expressions of Bcl-2 AKT and phosphorylated AKT were analyzed by Western blotting; In comparison to the controls a significant increase in the expression of miR-451 was associated with significantly decreased expressions of Bcl-2 AKT and p-AKT and a significant increase in the apoptosis rate drug resistance; breast cancer;esophageal cancer hsa-miR-452-5p BCL2 0.612108901803716 0.0110020550949664 -0.899142762694703 2.93311234351261e-06 mirMAP -0.19866322434232 5.33384755553303e-05 NA NA NA hsa-miR-455-5p BCL2 0.644390760445571 0.00262275997170695 -0.899142762694703 2.93311234351261e-06 mirMAP -0.396712641936315 9.54147980700326e-14 NA NA NA hsa-miR-542-3p BCL2 1.12416854979951 1.02649534578738e-12 -0.899142762694703 2.93311234351261e-06 mirMAP -0.215257770709208 0.00329622139421902 NA NA NA hsa-miR-577 BCL2 0.615893340074725 0.210494450869356 -0.899142762694703 2.93311234351261e-06 PITA -0.141656139039771 4.69420313328151e-08 NA NA NA hsa-miR-582-5p BCL2 0.0720675907490005 0.728284850619144 -0.899142762694703 2.93311234351261e-06 PITA -0.124068975744705 0.0330435180032155 NA NA NA hsa-miR-590-3p BCL2 0.858742926831233 0.000127281269371976 -0.899142762694703 2.93311234351261e-06 miRanda;mirMAP -0.318339749200423 6.43915706978043e-10 NA NA NA hsa-miR-590-5p BCL2 0.932604531809045 8.39043954167884e-05 -0.899142762694703 2.93311234351261e-06 miRanda -0.325395689444373 1.59229763950107e-11 NA NA NA hsa-miR-629-5p BCL2 0.812778109967063 7.88203035554668e-05 -0.899142762694703 2.93311234351261e-06 mirMAP -0.272239447772002 1.74083722051538e-06 NA NA NA hsa-miR-7-1-3p BCL2 0.94398354303717 7.5771319809992e-05 -0.899142762694703 2.93311234351261e-06 mirMAP -0.313200679489903 6.86559579820048e-11 NA NA NA hsa-miR-7-5p BCL2 1.20202447072014 0.000123775346787165 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;miRTarBase;mirMAP -0.26584380813364 7.84866931741742e-12 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-96-5p BCL2 1.44821155854693 6.56312590328933e-06 -0.899142762694703 2.93311234351261e-06 miRNAWalker2_validate;TargetScan -0.256121183455027 9.63548441575232e-12 NA NA NA hsa-let-7c-5p BCL2L1 -0.148489254129201 0.548077841857242 0.538910243524146 0.000232226072126618 miRNAWalker2_validate;miRTarBase -0.173534489241295 1.50926265717428e-06 20347499 Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA liver cancer hsa-miR-133a-3p BCL2L1 -2.63342156915404 5.72661351480585e-12 0.538910243524146 0.000232226072126618 miRNAWalker2_validate -0.109066541881666 9.61762914141871e-07 23756231 Furthermore bioinformatic prediction and experimental validation were applied to identify target genes of miR-133a and the results revealed that the anti-tumor effect of miR-133a was probably due to targeting and repressing of Bcl-xL and Mcl-1 expression sarcoma hsa-miR-23b-3p BCL2L1 -0.228571473429 0.0553601132069074 0.538910243524146 0.000232226072126618 miRNAWalker2_validate -0.274620801431438 0.000374432863426817 NA NA NA hsa-miR-107 CAPN2 0.85152957824299 1.22369651446858e-11 -0.355869916724213 0.00377121000418687 miRanda -0.148458169899052 0.0116116868506522 NA NA NA hsa-miR-129-5p CAPN2 -1.61803714443871 4.93214379865694e-06 -0.355869916724213 0.00377121000418687 miRanda -0.0529101129074288 0.0127856687824301 NA NA NA hsa-miR-1468-5p CAPN2 -0.391561330012437 0.0601460811871911 -0.355869916724213 0.00377121000418687 MirTarget -0.145121102986209 5.60163018184986e-05 NA NA NA hsa-miR-20a-3p CAPN2 0.703027135708586 0.022464856696655 -0.355869916724213 0.00377121000418687 MirTarget -0.0751054367429131 0.00279941990298791 NA NA NA hsa-miR-320a CAPN2 0.451741078692272 0.00893327237386749 -0.355869916724213 0.00377121000418687 miRanda -0.0928749974730444 0.0343397803402095 NA NA NA hsa-miR-320b CAPN2 1.21733873788625 7.99882585998487e-07 -0.355869916724213 0.00377121000418687 miRanda -0.0727291892497421 0.015234255464545 NA NA NA hsa-miR-33a-3p CAPN2 0.21453033253985 0.371591474252951 -0.355869916724213 0.00377121000418687 mirMAP -0.0654705877936168 0.0472152787532349 NA NA NA hsa-miR-421 CAPN2 1.26653675546617 2.35180826009926e-08 -0.355869916724213 0.00377121000418687 miRanda -0.145031572876985 7.24945134868676e-06 NA NA NA hsa-miR-590-5p CAPN2 0.932604531809045 8.39043954167884e-05 -0.355869916724213 0.00377121000418687 miRanda -0.0785716367915869 0.0126449165580613 NA NA NA hsa-miR-7-5p CAPN2 1.20202447072014 0.000123775346787165 -0.355869916724213 0.00377121000418687 miRNAWalker2_validate -0.0688378938434955 0.00664629762609607 NA NA NA hsa-miR-125a-5p CASP10 -0.261743402170195 0.116107665196876 0.0255772717137255 0.887379559297502 mirMAP -0.141272827975392 0.0347740712330611 NA NA NA hsa-miR-125b-5p CASP10 -0.176364454911029 0.43771853581292 0.0255772717137255 0.887379559297502 mirMAP -0.22604363493274 2.42793658240119e-06 NA NA NA hsa-miR-129-5p CASP10 -1.61803714443871 4.93214379865694e-06 0.0255772717137255 0.887379559297502 mirMAP -0.0753595429630438 0.0153302702756995 NA NA NA hsa-miR-145-3p CASP10 -1.47406550617505 3.24220742398631e-11 0.0255772717137255 0.887379559297502 mirMAP -0.112124808890928 0.0191709754902153 NA NA NA hsa-miR-145-5p CASP10 -1.54503595327403 2.65080161523141e-09 0.0255772717137255 0.887379559297502 mirMAP -0.11422130987668 0.00546533707431967 NA NA NA hsa-miR-195-3p CASP10 -0.694544351365025 0.000214711021317786 0.0255772717137255 0.887379559297502 mirMAP -0.153771172134439 0.00863642687949664 NA NA NA hsa-miR-217 CASP10 1.80436036080313 4.35626260547444e-10 0.0255772717137255 0.887379559297502 mirMAP -0.124766312123663 0.000672090092084596 NA NA NA hsa-let-7c-5p CASP3 -0.148489254129201 0.548077841857242 -0.0868759327635171 0.486463528589164 MirTarget -0.197287856107596 3.39034685214002e-11 NA NA NA hsa-let-7e-5p CASP3 0.227253058773149 0.162290058199053 -0.0868759327635171 0.486463528589164 MirTarget;miRNATAP -0.135280940885113 0.00413998415003452 NA NA NA hsa-miR-139-5p CASP3 -1.41674256628297 4.51005988644234e-14 -0.0868759327635171 0.486463528589164 miRanda -0.121815611838633 0.00159131121027885 NA NA NA hsa-miR-195-3p CASP3 -0.694544351365025 0.000214711021317786 -0.0868759327635171 0.486463528589164 MirTarget -0.16159658152277 5.42898186299828e-05 NA NA NA hsa-miR-28-5p CASP3 -0.22318016376076 0.0194144033008573 -0.0868759327635171 0.486463528589164 miRanda -0.242209985001119 0.00347222954936596 NA NA NA hsa-miR-30a-5p CASP3 -0.742755040631906 3.79943871404435e-05 -0.0868759327635171 0.486463528589164 miRNATAP -0.236527304869001 6.90456934685875e-09 NA NA NA hsa-miR-125a-5p CASP6 -0.261743402170195 0.116107665196876 0.115995045643139 0.379393409058256 miRanda -0.106325420954951 0.0294315874498031 NA NA NA hsa-miR-129-5p CASP6 -1.61803714443871 4.93214379865694e-06 0.115995045643139 0.379393409058256 MirTarget;miRanda -0.0607309073026314 0.00734819516490995 NA NA NA hsa-miR-23b-3p CASP7 -0.228571473429 0.0553601132069074 -0.19153655067353 0.211248877650473 MirTarget -0.280547934877951 0.000447862986046719 NA NA NA hsa-miR-129-5p CASP8 -1.61803714443871 4.93214379865694e-06 0.734590658515638 3.56383484351654e-10 miRanda -0.104379399238566 3.37760427297831e-07 NA NA NA hsa-miR-143-3p CASP8 -0.941264957317006 7.19918948927784e-06 0.734590658515638 3.56383484351654e-10 MirTarget -0.213565346923482 2.35781949094754e-10 NA NA NA hsa-let-7a-5p CASP9 0.298659498236324 0.00963231738125113 -0.538812245140001 5.30209860086014e-09 miRNAWalker2_validate -0.127035389586059 0.013347946592267 NA NA NA hsa-miR-15a-5p CASP9 1.07800995489566 4.32072598796529e-10 -0.538812245140001 5.30209860086014e-09 mirMAP -0.123245680093592 0.000140094207419561 NA NA NA hsa-miR-17-5p CASP9 1.57209612312313 5.10453838016207e-11 -0.538812245140001 5.30209860086014e-09 TargetScan -0.0977269547272811 2.1924978305157e-05 NA NA NA hsa-miR-199a-3p CASP9 1.04459501900922 2.43330173715104e-11 -0.538812245140001 5.30209860086014e-09 mirMAP -0.164028720506034 3.64653398829862e-06 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 1.04524477057703 2.47846951108535e-11 -0.538812245140001 5.30209860086014e-09 mirMAP -0.163745200067572 3.70661320324365e-06 NA NA NA hsa-miR-222-5p CASP9 1.40730191326147 1.77506391601374e-06 -0.538812245140001 5.30209860086014e-09 mirMAP -0.0643748174828095 0.000928053254986007 NA NA NA hsa-miR-342-5p CASP9 0.894527325844054 0.000286684345522657 -0.538812245140001 5.30209860086014e-09 MirTarget -0.0527748071759454 0.0232034992149805 NA NA NA hsa-miR-450b-5p CASP9 1.36137774989901 7.45499130609203e-11 -0.538812245140001 5.30209860086014e-09 mirMAP -0.0918801615273848 0.000549623272086724 NA NA NA hsa-miR-7-5p CASP9 1.20202447072014 0.000123775346787165 -0.538812245140001 5.30209860086014e-09 miRNAWalker2_validate -0.0546467151861093 0.00494869403845157 NA NA NA hsa-miR-107 CFLAR 0.85152957824299 1.22369651446858e-11 -0.0407334826849102 0.678591419868136 miRanda -0.127408252124823 0.00617232185786159 NA NA NA hsa-miR-130b-3p CFLAR 1.29757792612022 1.70655148591568e-06 -0.0407334826849102 0.678591419868136 mirMAP -0.125714459150907 2.09683173342985e-09 NA NA NA hsa-miR-15b-5p CFLAR 0.637819606405168 0.000580041575431604 -0.0407334826849102 0.678591419868136 mirMAP -0.133365598402518 2.70032379959283e-05 NA NA NA hsa-miR-16-5p CFLAR 0.468459442059375 0.02635007201346 -0.0407334826849102 0.678591419868136 mirMAP -0.0828377710043778 0.00337919569054906 NA NA NA hsa-miR-186-5p CFLAR 0.35512789129261 0.0196931838168008 -0.0407334826849102 0.678591419868136 mirMAP -0.0996415192621186 0.011838974534463 NA NA NA hsa-miR-301a-3p CFLAR 1.22580753116505 5.84016077664577e-09 -0.0407334826849102 0.678591419868136 mirMAP -0.0845139766966346 0.00214197934146958 NA NA NA hsa-miR-30b-3p CFLAR 0.252088263642787 0.216818735503048 -0.0407334826849102 0.678591419868136 mirMAP -0.0909734375581905 0.00198774642736922 NA NA NA hsa-miR-320a CFLAR 0.451741078692272 0.00893327237386749 -0.0407334826849102 0.678591419868136 miRanda -0.0793073332393037 0.0223842608367437 NA NA NA hsa-miR-320b CFLAR 1.21733873788625 7.99882585998487e-07 -0.0407334826849102 0.678591419868136 miRanda -0.0901199043741467 0.000128344729188447 NA NA NA hsa-miR-326 CFLAR -0.552187708067123 0.039648668341622 -0.0407334826849102 0.678591419868136 miRanda;mirMAP -0.0803096113318977 0.000277256686602526 NA NA NA hsa-miR-330-5p CFLAR 0.621676971901542 0.00233177378595631 -0.0407334826849102 0.678591419868136 miRanda -0.108417350723165 0.000179812394190624 NA NA NA hsa-miR-339-5p CFLAR 0.51232205151031 0.0560469213103598 -0.0407334826849102 0.678591419868136 miRanda -0.0679424696085799 0.00216452610706209 NA NA NA hsa-miR-421 CFLAR 1.26653675546617 2.35180826009926e-08 -0.0407334826849102 0.678591419868136 miRanda -0.135865984243208 8.76704514756668e-08 NA NA NA hsa-miR-455-5p CFLAR 0.644390760445571 0.00262275997170695 -0.0407334826849102 0.678591419868136 miRanda -0.0653740560873083 0.0186869787788754 NA NA NA hsa-miR-484 CFLAR 0.401753773460753 0.0490851523101605 -0.0407334826849102 0.678591419868136 mirMAP -0.0662039333093487 0.0240731420581726 NA NA NA hsa-miR-550a-5p CFLAR 1.55643544666056 8.53097422057455e-09 -0.0407334826849102 0.678591419868136 mirMAP -0.105774461924615 8.64259117129113e-07 NA NA NA hsa-miR-577 CFLAR 0.615893340074725 0.210494450869356 -0.0407334826849102 0.678591419868136 MirTarget -0.0584054064714013 7.43400923172996e-06 NA NA NA hsa-miR-590-3p CFLAR 0.858742926831233 0.000127281269371976 -0.0407334826849102 0.678591419868136 MirTarget;miRanda -0.0807973027676343 0.00217625711954144 NA NA NA hsa-miR-7-5p CFLAR 1.20202447072014 0.000123775346787165 -0.0407334826849102 0.678591419868136 miRNAWalker2_validate -0.0745712727690954 0.000186482676614826 NA NA NA hsa-miR-106a-5p CHP2 0.587427028487119 0.00838999163993323 -1.34876532083084 0.0903912496796366 MirTarget -0.565465772270169 0.00970598790834211 NA NA NA hsa-miR-20a-5p CHP2 1.57190995476158 8.72275528729458e-12 -1.34876532083084 0.0903912496796366 MirTarget -0.43254758502925 0.0341971898381353 NA NA NA hsa-miR-152-3p CHUK -0.111001946024117 0.385698870309139 0.260508655820102 0.00541846716349918 MirTarget -0.232227140209855 2.32379778653902e-07 NA NA NA hsa-miR-195-5p CHUK -1.07154705036962 4.16544134775761e-08 0.260508655820102 0.00541846716349918 miRNAWalker2_validate;MirTarget -0.209408932879662 1.77454617069446e-14 NA NA NA hsa-miR-23b-3p CHUK -0.228571473429 0.0553601132069074 0.260508655820102 0.00541846716349918 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.10524484472265 0.0326504816656031 NA NA NA hsa-miR-342-3p CHUK 0.235422340773149 0.290471946350276 0.260508655820102 0.00541846716349918 miRanda -0.067197825451139 0.00915317052352965 NA NA NA hsa-miR-376c-3p CHUK -0.0732288934813714 0.755575081658912 0.260508655820102 0.00541846716349918 MirTarget -0.0761378062380509 0.00175999597123122 NA NA NA hsa-miR-497-5p CHUK -0.486115215577409 0.00973897247186318 0.260508655820102 0.00541846716349918 MirTarget -0.203365591669603 4.10879523802409e-12 NA NA NA hsa-miR-181d-5p CSF2RB 0.731427823879034 2.03301498870394e-05 -0.461676474510217 0.0675486271528511 MirTarget -0.338004519305551 0.000143909138685016 NA NA NA hsa-miR-19a-3p CSF2RB 1.71062381299889 1.72281025366819e-11 -0.461676474510217 0.0675486271528511 MirTarget -0.16437897005035 0.00489574779570189 NA NA NA hsa-miR-19b-3p CSF2RB 0.936987029203338 9.28141970787798e-06 -0.461676474510217 0.0675486271528511 MirTarget -0.193167188709285 0.00749200260959042 NA NA NA hsa-miR-30b-3p CSF2RB 0.252088263642787 0.216818735503048 -0.461676474510217 0.0675486271528511 MirTarget -0.154978359151083 0.0433203469530381 NA NA NA hsa-miR-532-5p CSF2RB 1.45407925817457 1.88450871132345e-14 -0.461676474510217 0.0675486271528511 MirTarget -0.177443591702055 0.0226949012567565 NA NA NA hsa-miR-139-5p CYCS -1.41674256628297 4.51005988644234e-14 0.0721482471492143 0.55415131411682 miRanda -0.159191346972796 2.06805152063917e-05 NA NA NA hsa-miR-34c-5p CYCS 1.37406314990472 2.42956736488761e-09 0.0721482471492143 0.55415131411682 miRanda -0.101560132950676 0.0014783959803471 NA NA NA hsa-miR-148a-3p DFFA -0.18108394434325 0.495345303586758 0.117992659830063 0.13871477946653 mirMAP -0.0508268383782932 0.00518370051839305 NA NA NA hsa-miR-155-5p DFFA 0.708423342476697 0.00686702252429413 0.117992659830063 0.13871477946653 mirMAP -0.0504458794841679 0.00588222438588544 NA NA NA hsa-miR-26a-2-3p DFFA 0.0619487388777404 0.765401751442771 0.117992659830063 0.13871477946653 mirMAP -0.0647257696210029 0.00639697243825989 NA NA NA hsa-miR-26a-5p DFFA -0.507487084157331 3.23715933371269e-05 0.117992659830063 0.13871477946653 mirMAP -0.189967019947448 1.33669896287203e-06 NA NA NA hsa-miR-26b-5p DFFA -0.499493687076043 0.0118149973400486 0.117992659830063 0.13871477946653 mirMAP -0.0882904578334895 0.000264468292210902 NA NA NA hsa-miR-342-3p DFFA 0.235422340773149 0.290471946350276 0.117992659830063 0.13871477946653 mirMAP -0.0835273072759172 0.000108764713548902 NA NA NA hsa-miR-664a-3p DFFA -0.0290482945770787 0.844010225386475 0.117992659830063 0.13871477946653 mirMAP -0.0922044549909001 0.00550106388727798 NA NA NA hsa-miR-199a-5p DFFB 0.723739336873244 5.69674696426761e-05 0.52728680717102 8.90440956505136e-06 miRanda -0.0946378911342943 0.0201342511845505 NA NA NA hsa-miR-199b-5p DFFB 0.621733599295605 0.000811860893066088 0.52728680717102 8.90440956505136e-06 miRanda -0.0873505866573705 0.0274488162311929 NA NA NA hsa-miR-28-5p DFFB -0.22318016376076 0.0194144033008573 0.52728680717102 8.90440956505136e-06 miRanda -0.299636092114583 0.000173382631172655 NA NA NA hsa-miR-365a-3p DFFB -0.801671336684825 1.28258342849568e-06 0.52728680717102 8.90440956505136e-06 MirTarget -0.263041167324976 7.36050600629175e-10 NA NA NA hsa-miR-495-3p DFFB -0.024887553302567 0.897251687801771 0.52728680717102 8.90440956505136e-06 mirMAP -0.10129207736746 0.00844134413314038 NA NA NA hsa-miR-130a-3p ENDOD1 0.218018009582956 0.274232880676821 -0.311613833349303 0.0226809514564935 MirTarget -0.140284875828952 0.000846873770034743 NA NA NA hsa-miR-130b-3p ENDOD1 1.29757792612022 1.70655148591568e-06 -0.311613833349303 0.0226809514564935 MirTarget -0.188309660817673 1.28905887030641e-10 NA NA NA hsa-miR-16-1-3p ENDOD1 1.23864765632542 1.24544799589822e-08 -0.311613833349303 0.0226809514564935 mirMAP -0.234601300297845 4.1746045656773e-10 NA NA NA hsa-miR-181a-5p ENDOD1 1.39352013383959 4.74824377258519e-17 -0.311613833349303 0.0226809514564935 MirTarget -0.138532416240404 0.0036643747013793 NA NA NA hsa-miR-181b-5p ENDOD1 1.44365471425231 6.03807007335243e-15 -0.311613833349303 0.0226809514564935 MirTarget -0.135648508698445 0.00159746359997696 NA NA NA hsa-miR-192-5p ENDOD1 2.0867723747501 3.57854249239079e-08 -0.311613833349303 0.0226809514564935 miRNAWalker2_validate -0.101360061412654 1.60841216302576e-06 NA NA NA hsa-miR-193a-3p ENDOD1 0.148284355948959 0.379093889907371 -0.311613833349303 0.0226809514564935 miRanda -0.133876214231711 0.0076148162071959 NA NA NA hsa-miR-193b-3p ENDOD1 -0.0325435210716751 0.883410452152887 -0.311613833349303 0.0226809514564935 miRNAWalker2_validate -0.122250924484136 0.00120354462998073 NA NA NA hsa-miR-19a-3p ENDOD1 1.71062381299889 1.72281025366819e-11 -0.311613833349303 0.0226809514564935 mirMAP -0.182362250378328 3.22356774730592e-09 NA NA NA hsa-miR-19b-3p ENDOD1 0.936987029203338 9.28141970787798e-06 -0.311613833349303 0.0226809514564935 mirMAP -0.237551778230664 3.71869701486957e-10 NA NA NA hsa-miR-200b-3p ENDOD1 2.06025765178663 3.07718049337497e-10 -0.311613833349303 0.0226809514564935 TargetScan -0.0857291377755466 0.000469850311602117 NA NA NA hsa-miR-20a-3p ENDOD1 0.703027135708586 0.022464856696655 -0.311613833349303 0.0226809514564935 MirTarget -0.171120094690884 2.76428356160619e-10 NA NA NA hsa-miR-26b-3p ENDOD1 0.312629571566403 0.245454206213408 -0.311613833349303 0.0226809514564935 mirMAP -0.14559010033984 2.02394404320576e-06 NA NA NA hsa-miR-301a-3p ENDOD1 1.22580753116505 5.84016077664577e-09 -0.311613833349303 0.0226809514564935 MirTarget -0.231199530613103 7.85744189987185e-10 NA NA NA hsa-miR-326 ENDOD1 -0.552187708067123 0.039648668341622 -0.311613833349303 0.0226809514564935 miRanda -0.114439968144638 0.00022029823881127 NA NA NA hsa-miR-330-5p ENDOD1 0.621676971901542 0.00233177378595631 -0.311613833349303 0.0226809514564935 miRanda -0.198151597949692 8.3321160005516e-07 NA NA NA hsa-miR-335-3p ENDOD1 2.29463721765513 4.1956113745077e-18 -0.311613833349303 0.0226809514564935 MirTarget -0.0901797605615059 0.00223816580858384 NA NA NA hsa-miR-3607-3p ENDOD1 0.479939234340415 0.251616873367277 -0.311613833349303 0.0226809514564935 MirTarget;miRNATAP -0.0950670288082683 2.72343966983797e-06 NA NA NA hsa-miR-361-5p ENDOD1 0.538048008019709 1.61165802415302e-07 -0.311613833349303 0.0226809514564935 MirTarget;miRanda -0.191302401648932 0.0206219643071364 NA NA NA hsa-miR-3613-5p ENDOD1 1.03938524872813 2.63575941507995e-05 -0.311613833349303 0.0226809514564935 MirTarget -0.235074729013204 2.06554842378107e-13 NA NA NA hsa-miR-362-3p ENDOD1 0.994614346444282 4.39793878186399e-05 -0.311613833349303 0.0226809514564935 miRanda -0.150245024797206 1.50454324927016e-05 NA NA NA hsa-miR-429 ENDOD1 1.58250682050303 4.75828087352234e-05 -0.311613833349303 0.0226809514564935 miRanda;miRNATAP -0.0964447299313365 5.34650834240703e-06 NA NA NA hsa-miR-450b-5p ENDOD1 1.36137774989901 7.45499130609203e-11 -0.311613833349303 0.0226809514564935 MirTarget;mirMAP -0.166575920617553 1.33193357201937e-05 NA NA NA hsa-miR-454-3p ENDOD1 0.823770738595667 1.30339728183332e-05 -0.311613833349303 0.0226809514564935 MirTarget -0.301914113889108 7.07220580423927e-13 NA NA NA hsa-miR-589-3p ENDOD1 1.00357906465313 8.20399071001461e-05 -0.311613833349303 0.0226809514564935 mirMAP -0.165363386088846 9.29915203644657e-07 NA NA NA hsa-miR-589-5p ENDOD1 1.20000320800112 1.34209467040505e-13 -0.311613833349303 0.0226809514564935 MirTarget -0.191541161783657 0.000101006914588087 NA NA NA hsa-miR-590-3p ENDOD1 0.858742926831233 0.000127281269371976 -0.311613833349303 0.0226809514564935 miRanda -0.253521599845992 1.0341559304664e-12 NA NA NA hsa-miR-10b-3p EXOG 0.448860145188521 0.00703361939318676 0.214313792113109 0.0375013728029055 MirTarget -0.127291261648431 0.00076516290412694 NA NA NA hsa-miR-200b-3p EXOG 2.06025765178663 3.07718049337497e-10 0.214313792113109 0.0375013728029055 MirTarget -0.0985901616284291 5.11522205487707e-08 NA NA NA hsa-miR-200c-3p EXOG 1.74925752003763 3.42000026705311e-08 0.214313792113109 0.0375013728029055 MirTarget -0.123031843261078 3.77684683524395e-11 NA NA NA hsa-miR-24-3p EXOG 0.425646348491286 0.00136678638934554 0.214313792113109 0.0375013728029055 MirTarget -0.164436212800873 0.000546494723410485 NA NA NA hsa-miR-326 EXOG -0.552187708067123 0.039648668341622 0.214313792113109 0.0375013728029055 miRanda -0.146765846042007 9.01684191177913e-11 NA NA NA hsa-miR-330-5p EXOG 0.621676971901542 0.00233177378595631 0.214313792113109 0.0375013728029055 miRanda -0.155558776137011 2.3991848529734e-07 NA NA NA hsa-miR-339-5p EXOG 0.51232205151031 0.0560469213103598 0.214313792113109 0.0375013728029055 miRanda -0.0644684017995331 0.00580003175785733 NA NA NA hsa-miR-362-3p EXOG 0.994614346444282 4.39793878186399e-05 0.214313792113109 0.0375013728029055 MirTarget;miRanda -0.0565753535408211 0.032153997263597 NA NA NA hsa-miR-429 EXOG 1.58250682050303 4.75828087352234e-05 0.214313792113109 0.0375013728029055 MirTarget;miRanda -0.0933735402001006 2.660258986747e-09 NA NA NA hsa-miR-484 EXOG 0.401753773460753 0.0490851523101605 0.214313792113109 0.0375013728029055 miRNAWalker2_validate;miRNATAP -0.0980161731488855 0.00143584176583824 NA NA NA hsa-miR-625-5p EXOG 0.748754910408313 0.00783938428700196 0.214313792113109 0.0375013728029055 MirTarget -0.108097288318507 1.08589009641977e-06 NA NA NA hsa-miR-7-1-3p EXOG 0.94398354303717 7.5771319809992e-05 0.214313792113109 0.0375013728029055 MirTarget -0.111422229860537 1.50442813002234e-05 NA NA NA hsa-miR-129-5p FADD -1.61803714443871 4.93214379865694e-06 0.372355072917092 0.00143917499690897 miRanda -0.0614147166766085 0.00233706480278389 NA NA NA hsa-miR-361-5p FAS 0.538048008019709 1.61165802415302e-07 0.165361884595015 0.414018918898716 miRanda -0.392077711712109 0.00124982046459676 NA NA NA hsa-let-7e-5p FASLG 0.227253058773149 0.162290058199053 0.53750001836942 0.081348046612573 miRNATAP -0.406363832920736 0.000506478526276418 NA NA NA hsa-miR-326 IKBKB -0.552187708067123 0.039648668341622 0.165320516231698 0.0477766322517597 miRanda -0.0733578347753369 9.09933852880651e-05 NA NA NA hsa-miR-17-3p IKBKG 1.37838995268509 5.00444740462873e-13 -0.127312396199058 0.199217186996528 mirMAP -0.0879625223592978 0.0036735657809823 NA NA NA hsa-miR-338-5p IKBKG -0.420442436641152 0.0583175290447746 -0.127312396199058 0.199217186996528 mirMAP -0.0602093723353649 0.0273434244565474 NA NA NA hsa-miR-30a-5p IL1A -0.742755040631906 3.79943871404435e-05 1.03991487672554 0.00840612663086519 MirTarget -0.348478167730163 0.00915789596044668 NA NA NA hsa-miR-126-5p IL1R1 0.450893496822779 0.0112966412858755 0.0774863445440346 0.657011719623057 mirMAP -0.219705460635774 0.000230223027370633 NA NA NA hsa-miR-130b-5p IL1R1 1.47709791778827 1.34679413565661e-06 0.0774863445440346 0.657011719623057 mirMAP -0.269952494151433 1.4952684186717e-16 NA NA NA hsa-miR-140-5p IL1R1 0.132398579631585 0.457960134430787 0.0774863445440346 0.657011719623057 miRanda -0.225737730445523 0.000160331353540247 NA NA NA hsa-miR-17-3p IL1R1 1.37838995268509 5.00444740462873e-13 0.0774863445440346 0.657011719623057 mirMAP -0.346710245639437 1.94998171715775e-11 NA NA NA hsa-miR-186-5p IL1R1 0.35512789129261 0.0196931838168008 0.0774863445440346 0.657011719623057 mirMAP -0.466358567600904 6.96381820542955e-12 NA NA NA hsa-miR-192-5p IL1R1 2.0867723747501 3.57854249239079e-08 0.0774863445440346 0.657011719623057 miRNAWalker2_validate -0.143361190621522 8.17071706780348e-08 NA NA NA hsa-miR-197-3p IL1R1 0.540951726189935 0.00440139185360704 0.0774863445440346 0.657011719623057 miRNAWalker2_validate -0.392951669413415 2.42410717314103e-13 NA NA NA hsa-miR-215-5p IL1R1 1.10296552366805 0.0225256935718223 0.0774863445440346 0.657011719623057 miRNAWalker2_validate -0.0679736351011653 0.00181298681210684 NA NA NA hsa-miR-24-3p IL1R1 0.425646348491286 0.00136678638934554 0.0774863445440346 0.657011719623057 miRNATAP -0.354247879782533 9.58353837027574e-06 NA NA NA hsa-miR-26b-5p IL1R1 -0.499493687076043 0.0118149973400486 0.0774863445440346 0.657011719623057 mirMAP -0.296613072750442 1.55517139717597e-08 NA NA NA hsa-miR-30d-3p IL1R1 0.0608340295673737 0.708110230223927 0.0774863445440346 0.657011719623057 mirMAP -0.394372758125477 9.50626723123615e-10 NA NA NA hsa-miR-30e-3p IL1R1 -0.444998679251398 0.000501880465265124 0.0774863445440346 0.657011719623057 mirMAP -0.181304052880894 0.0317351025300153 NA NA NA hsa-miR-335-3p IL1R1 2.29463721765513 4.1956113745077e-18 0.0774863445440346 0.657011719623057 mirMAP -0.188327541580733 3.43342483254498e-07 NA NA NA hsa-miR-590-3p IL1R1 0.858742926831233 0.000127281269371976 0.0774863445440346 0.657011719623057 miRanda;miRNATAP -0.33602403548769 8.73123553666882e-14 NA NA NA hsa-miR-129-5p IL1RAP -1.61803714443871 4.93214379865694e-06 0.663143818017073 0.000192612407308983 miRanda -0.129135400144716 2.54277898635541e-05 NA NA NA hsa-miR-139-5p IL1RAP -1.41674256628297 4.51005988644234e-14 0.663143818017073 0.000192612407308983 miRanda -0.184570666624934 0.000930106225931395 NA NA NA hsa-miR-29a-3p IL1RAP -0.235052170104117 0.138527567930958 0.663143818017073 0.000192612407308983 MirTarget;miRNATAP -0.183803726704981 0.00871264387644999 NA NA NA hsa-miR-29c-3p IL1RAP -1.34143813218298 2.77493790306384e-12 0.663143818017073 0.000192612407308983 MirTarget;miRNATAP -0.244966587271458 6.78499858244955e-06 NA NA NA hsa-miR-362-3p IL3RA 0.994614346444282 4.39793878186399e-05 0.127243827673434 0.386342835255948 miRanda -0.0979896534826329 0.00910573362292925 NA NA NA hsa-miR-20a-3p IRAK3 0.703027135708586 0.022464856696655 -0.348797387038069 0.15544292867076 mirMAP -0.116156250627374 0.0208410651748783 NA NA NA hsa-miR-335-3p IRAK3 2.29463721765513 4.1956113745077e-18 -0.348797387038069 0.15544292867076 mirMAP -0.240721095373149 4.29151430183264e-06 NA NA NA hsa-miR-33a-5p IRAK3 0.372183130885047 0.335617783855811 -0.348797387038069 0.15544292867076 mirMAP -0.101860077849486 0.00859111405148901 NA NA NA hsa-miR-361-5p IRAK3 0.538048008019709 1.61165802415302e-07 -0.348797387038069 0.15544292867076 miRanda;mirMAP -0.354848402506715 0.0167062902667041 NA NA NA hsa-miR-421 IRAK3 1.26653675546617 2.35180826009926e-08 -0.348797387038069 0.15544292867076 miRanda;mirMAP -0.147911850636936 0.023654540310879 NA NA NA hsa-miR-429 IRAK3 1.58250682050303 4.75828087352234e-05 -0.348797387038069 0.15544292867076 miRanda -0.105840211537683 0.00599508687368144 NA NA NA hsa-miR-582-5p IRAK3 0.0720675907490005 0.728284850619144 -0.348797387038069 0.15544292867076 mirMAP -0.203807204152133 0.00509641500966489 NA NA NA hsa-miR-590-5p IRAK3 0.932604531809045 8.39043954167884e-05 -0.348797387038069 0.15544292867076 mirMAP -0.129814018266958 0.0391399296144534 NA NA NA hsa-miR-92a-3p IRAK3 1.06124545165614 6.51550014372282e-08 -0.348797387038069 0.15544292867076 mirMAP -0.24628377278307 0.000971676943389665 NA NA NA hsa-miR-193a-3p IRAK4 0.148284355948959 0.379093889907371 -0.0277777478111112 0.754974787898409 miRanda -0.0697102151879063 0.031433554071279 NA NA NA hsa-miR-199a-5p IRAK4 0.723739336873244 5.69674696426761e-05 -0.0277777478111112 0.754974787898409 miRanda -0.0693555269713573 0.0201718503794596 NA NA NA hsa-miR-320a IRAK4 0.451741078692272 0.00893327237386749 -0.0277777478111112 0.754974787898409 miRanda -0.0635208747159295 0.0432321741759599 NA NA NA hsa-miR-493-5p IRAK4 1.32223598235404 3.01688809960418e-10 -0.0277777478111112 0.754974787898409 mirMAP -0.080247158510573 0.00121490570026042 NA NA NA hsa-miR-106b-5p MAP3K14 1.08518388423396 4.82746923373852e-09 -0.295411281342413 0.0260420232156854 MirTarget -0.180330577414574 2.02801933308072e-05 NA NA NA hsa-miR-17-3p MAP3K14 1.37838995268509 5.00444740462873e-13 -0.295411281342413 0.0260420232156854 MirTarget -0.235277207403673 3.34303537642209e-09 NA NA NA hsa-miR-17-5p MAP3K14 1.57209612312313 5.10453838016207e-11 -0.295411281342413 0.0260420232156854 MirTarget -0.190681674908026 2.04453694624241e-09 NA NA NA hsa-miR-185-3p MAP3K14 1.38509197368746 3.93425296894499e-10 -0.295411281342413 0.0260420232156854 MirTarget -0.195361251015788 5.54091846998116e-08 NA NA NA hsa-miR-1976 MAP3K14 0.888680419203938 2.16642020734521e-05 -0.295411281342413 0.0260420232156854 MirTarget -0.130168041918794 0.00118069643237595 NA NA NA hsa-miR-20a-5p MAP3K14 1.57190995476158 8.72275528729458e-12 -0.295411281342413 0.0260420232156854 MirTarget -0.166059635126214 6.25607792205725e-07 NA NA NA hsa-miR-2110 MAP3K14 0.359318473683641 0.126104910543249 -0.295411281342413 0.0260420232156854 MirTarget -0.11934538098515 0.00109695158758914 NA NA NA hsa-miR-331-3p MAP3K14 0.818192524829557 0.000359485856225569 -0.295411281342413 0.0260420232156854 MirTarget -0.106792796057222 0.00231022086176546 NA NA NA hsa-miR-345-5p MAP3K14 0.906439112334506 0.00375888297100119 -0.295411281342413 0.0260420232156854 MirTarget -0.121221771586808 2.57462254274984e-06 NA NA NA hsa-miR-362-3p MAP3K14 0.994614346444282 4.39793878186399e-05 -0.295411281342413 0.0260420232156854 miRanda -0.0743005912476132 0.0294762117344686 NA NA NA hsa-miR-429 MAP3K14 1.58250682050303 4.75828087352234e-05 -0.295411281342413 0.0260420232156854 miRNATAP -0.126795735693434 3.49572876976808e-10 NA NA NA hsa-miR-542-3p MAP3K14 1.12416854979951 1.02649534578738e-12 -0.295411281342413 0.0260420232156854 miRanda -0.160770274407397 0.00118051883207199 27107696 miR 542 3p suppresses invasion and metastasis by targeting the proto oncogene serine/threonine protein kinase PIM1 in melanoma; The proto-oncogene serine/threonine protein kinase PIM1 was identified as a direct target of miR-542-3p using luciferase reporter assay qRT-PCR and western blot analyses metastasis melanoma hsa-miR-874-3p MAP3K14 0.24291801110313 0.253403155001571 -0.295411281342413 0.0260420232156854 MirTarget -0.100186871281804 0.00896630119992511 NA NA NA hsa-miR-93-5p MAP3K14 1.68243825551104 4.62947431501061e-15 -0.295411281342413 0.0260420232156854 MirTarget -0.175936719920584 6.24777594616569e-07 NA NA NA hsa-miR-9-5p NFKB1 -0.887069929841985 0.00529865051479737 0.171120548704913 0.0339699651590382 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0600730312495175 7.41884081130774e-05 NA NA NA hsa-miR-24-3p NFKBIA 0.425646348491286 0.00136678638934554 -0.631280530065371 5.52513837497122e-07 miRNAWalker2_validate -0.141751193342446 0.0178751861962061 NA NA NA hsa-miR-335-5p NFKBIA 0.576542642348884 0.01886326850059 -0.631280530065371 5.52513837497122e-07 miRNAWalker2_validate -0.0969127725291963 0.00245229482129995 NA NA NA hsa-miR-590-3p NFKBIA 0.858742926831233 0.000127281269371976 -0.631280530065371 5.52513837497122e-07 miRanda -0.0721215847024605 0.0387033989531078 NA NA NA hsa-let-7d-5p NGF 0.686819803681087 1.08347860862215e-06 -0.462088517867856 0.166953331832769 MirTarget -0.620237987554177 1.4471375958169e-05 NA NA NA hsa-let-7g-5p NGF 0.296128761926282 0.0296823495976068 -0.462088517867856 0.166953331832769 MirTarget -0.784396596061535 1.60720097358693e-07 NA NA NA hsa-miR-320b NGF 1.21733873788625 7.99882585998487e-07 -0.462088517867856 0.166953331832769 miRanda -0.232408820981967 0.00421569867846829 NA NA NA hsa-miR-423-5p NGF 0.554579912507932 7.65114789083517e-05 -0.462088517867856 0.166953331832769 MirTarget;miRNATAP -0.416546543170073 0.00441284912185688 NA NA NA hsa-miR-429 NGF 1.58250682050303 4.75828087352234e-05 -0.462088517867856 0.166953331832769 miRanda -0.35062173952661 3.8824604215482e-12 NA NA NA hsa-miR-98-5p NGF 0.72508924193932 6.07191196761022e-10 -0.462088517867856 0.166953331832769 MirTarget -0.492108805714805 0.00445439770179829 NA NA NA hsa-miR-16-1-3p NTRK1 1.23864765632542 1.24544799589822e-08 -0.702878820587119 0.00869100750038929 mirMAP -0.322569560542847 1.85068106002081e-05 NA NA NA hsa-miR-185-3p NTRK1 1.38509197368746 3.93425296894499e-10 -0.702878820587119 0.00869100750038929 MirTarget -0.233396014686477 0.00167754248731781 NA NA NA hsa-let-7f-1-3p PIK3CA 1.09636075438131 3.42037366931931e-10 0.194729143482303 0.0690781159814236 mirMAP -0.149666799535812 3.27640116833412e-05 NA NA NA hsa-miR-126-5p PIK3CA 0.450893496822779 0.0112966412858755 0.194729143482303 0.0690781159814236 mirMAP -0.176079552467285 1.17854319899384e-06 NA NA NA hsa-miR-142-5p PIK3CA 1.08445947321046 0.000126372881543671 0.194729143482303 0.0690781159814236 mirMAP -0.105207285665054 2.81345650221239e-06 NA NA NA hsa-miR-146a-5p PIK3CA 0.801543189433048 0.00411744525146003 0.194729143482303 0.0690781159814236 mirMAP -0.0916307588334622 6.85943965228299e-05 NA NA NA hsa-miR-148a-5p PIK3CA 0.0805913350009586 0.752183008225566 0.194729143482303 0.0690781159814236 mirMAP -0.141068697957446 1.76544805345295e-08 NA NA NA hsa-miR-148b-3p PIK3CA 0.719517328390822 3.51245964668412e-05 0.194729143482303 0.0690781159814236 miRNAWalker2_validate -0.151852132632465 3.99815835031636e-05 NA NA NA hsa-miR-16-2-3p PIK3CA 0.869267463341732 0.000785361809327569 0.194729143482303 0.0690781159814236 mirMAP -0.124747020505271 3.79598199045172e-07 NA NA NA hsa-miR-17-5p PIK3CA 1.57209612312313 5.10453838016207e-11 0.194729143482303 0.0690781159814236 miRNAWalker2_validate -0.0616698007579194 0.0191161386006369 NA NA NA hsa-miR-186-5p PIK3CA 0.35512789129261 0.0196931838168008 0.194729143482303 0.0690781159814236 mirMAP -0.219315021597991 2.46524180140228e-07 NA NA NA hsa-miR-200b-3p PIK3CA 2.06025765178663 3.07718049337497e-10 0.194729143482303 0.0690781159814236 TargetScan -0.0854412075997485 6.71354874842926e-06 NA NA NA hsa-miR-299-5p PIK3CA -0.162422032147768 0.435278723340297 0.194729143482303 0.0690781159814236 miRNATAP -0.112440708443198 0.000377746778987277 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.27585983480192 1.70509960024426e-05 0.194729143482303 0.0690781159814236 mirMAP -0.0799490506860706 0.000219376280423237 NA NA NA hsa-miR-320a PIK3CA 0.451741078692272 0.00893327237386749 0.194729143482303 0.0690781159814236 miRanda -0.120983312204323 0.00137935065184038 NA NA NA hsa-miR-320b PIK3CA 1.21733873788625 7.99882585998487e-07 0.194729143482303 0.0690781159814236 miRanda -0.11792238486637 4.07051940137235e-06 NA NA NA hsa-miR-335-5p PIK3CA 0.576542642348884 0.01886326850059 0.194729143482303 0.0690781159814236 miRNAWalker2_validate -0.157486721953154 1.19352567503085e-09 NA NA NA hsa-miR-339-5p PIK3CA 0.51232205151031 0.0560469213103598 0.194729143482303 0.0690781159814236 miRanda -0.140334776619182 3.02464392822942e-09 NA NA NA hsa-miR-3607-3p PIK3CA 0.479939234340415 0.251616873367277 0.194729143482303 0.0690781159814236 mirMAP -0.0800270701098754 3.77136817851482e-07 NA NA NA hsa-miR-374b-5p PIK3CA 0.00249900187478502 0.985380083859555 0.194729143482303 0.0690781159814236 mirMAP -0.244906665183641 3.30388405101214e-07 NA NA NA hsa-miR-450b-5p PIK3CA 1.36137774989901 7.45499130609203e-11 0.194729143482303 0.0690781159814236 mirMAP -0.0672765936539503 0.0260737991539768 NA NA NA hsa-miR-495-3p PIK3CA -0.024887553302567 0.897251687801771 0.194729143482303 0.0690781159814236 mirMAP -0.105120526037851 0.00201725997019777 NA NA NA hsa-miR-501-5p PIK3CA 1.59306197632625 2.04856600619363e-09 0.194729143482303 0.0690781159814236 mirMAP -0.0733889433050896 0.00322668530136352 NA NA NA hsa-miR-576-5p PIK3CA 0.872721964495849 5.20470410008775e-05 0.194729143482303 0.0690781159814236 PITA -0.134756577377079 5.1634273931206e-06 NA NA NA hsa-miR-577 PIK3CA 0.615893340074725 0.210494450869356 0.194729143482303 0.0690781159814236 mirMAP -0.0623397139064384 1.26253713647212e-05 NA NA NA hsa-miR-582-3p PIK3CA -0.104548775434833 0.640423116430294 0.194729143482303 0.0690781159814236 miRNATAP -0.102887637441851 0.000413241156874094 NA NA NA hsa-miR-590-3p PIK3CA 0.858742926831233 0.000127281269371976 0.194729143482303 0.0690781159814236 miRanda;mirMAP -0.174809526517214 4.67478841800302e-10 NA NA NA hsa-miR-590-5p PIK3CA 0.932604531809045 8.39043954167884e-05 0.194729143482303 0.0690781159814236 miRanda -0.157815325131793 2.83126566928395e-09 NA NA NA hsa-miR-7-1-3p PIK3CA 0.94398354303717 7.5771319809992e-05 0.194729143482303 0.0690781159814236 mirMAP -0.1534743423884 5.95162340489971e-09 NA NA NA hsa-miR-96-5p PIK3CA 1.44821155854693 6.56312590328933e-06 0.194729143482303 0.0690781159814236 TargetScan -0.102925641162433 8.65462553903472e-07 NA NA NA hsa-miR-130a-3p PIK3CB 0.218018009582956 0.274232880676821 0.487972336438506 1.06256864389617e-06 miRNATAP -0.120118816720037 0.000110881261212529 NA NA NA hsa-miR-195-3p PIK3CB -0.694544351365025 0.000214711021317786 0.487972336438506 1.06256864389617e-06 mirMAP -0.13885789455157 2.11127592118759e-05 NA NA NA hsa-miR-214-3p PIK3CB 1.06116688049966 3.26331448960978e-06 0.487972336438506 1.06256864389617e-06 miRNATAP -0.0873573569082889 0.00114536901773228 NA NA NA hsa-miR-29c-3p PIK3CB -1.34143813218298 2.77493790306384e-12 0.487972336438506 1.06256864389617e-06 miRNATAP -0.144829450024151 2.36364789406086e-06 NA NA NA hsa-miR-9-5p PIK3CB -0.887069929841985 0.00529865051479737 0.487972336438506 1.06256864389617e-06 miRNATAP -0.0811778495251049 2.28432608508581e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.252088263642787 0.216818735503048 -0.0311608960188332 0.85393242590672 MirTarget -0.211088025518264 2.94456229839616e-05 NA NA NA hsa-miR-30b-5p PIK3CD -0.0106833209203501 0.954966272944722 -0.0311608960188332 0.85393242590672 MirTarget -0.127049707365963 0.0210868789471298 NA NA NA hsa-miR-30d-5p PIK3CD 0.26829866064717 0.0228954180095085 -0.0311608960188332 0.85393242590672 MirTarget;miRNATAP -0.466167464019275 1.12163448330828e-07 NA NA NA hsa-miR-320b PIK3CD 1.21733873788625 7.99882585998487e-07 -0.0311608960188332 0.85393242590672 miRanda -0.102820646245335 0.0122324482672438 NA NA NA hsa-miR-324-5p PIK3CD 0.800946351685734 0.00101337664367375 -0.0311608960188332 0.85393242590672 miRanda -0.103806782901193 0.0136389205564886 NA NA NA hsa-miR-421 PIK3CD 1.26653675546617 2.35180826009926e-08 -0.0311608960188332 0.85393242590672 miRanda -0.130990705864954 0.00343678307821204 NA NA NA hsa-miR-7-5p PIK3CD 1.20202447072014 0.000123775346787165 -0.0311608960188332 0.85393242590672 miRTarBase;MirTarget;miRNATAP -0.110713446527457 0.00139815102421271 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-335-3p PIK3CG 2.29463721765513 4.1956113745077e-18 -0.431523776023951 0.105004494916123 mirMAP -0.236740995358545 3.30421401118699e-05 NA NA NA hsa-miR-421 PIK3CG 1.26653675546617 2.35180826009926e-08 -0.431523776023951 0.105004494916123 miRanda -0.222678259072787 0.00161023125714365 NA NA NA hsa-miR-502-5p PIK3CG 0.873538712251823 0.0012275719769761 -0.431523776023951 0.105004494916123 miRNATAP -0.17829233844257 0.0107350853192294 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-103a-3p PIK3R1 1.01322687786547 1.60813894223583e-11 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.142182303458125 0.0145875882589141 NA NA NA hsa-miR-106a-5p PIK3R1 0.587427028487119 0.00838999163993323 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.130078677669931 0.00118702908974724 NA NA NA hsa-miR-106b-5p PIK3R1 1.08518388423396 4.82746923373852e-09 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.336490450570336 1.05499898679502e-13 NA NA NA hsa-miR-107 PIK3R1 0.85152957824299 1.22369651446858e-11 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;miRNATAP -0.378607761454031 3.44237135388333e-08 NA NA NA hsa-miR-127-5p PIK3R1 0.809791853526294 0.000176206263785639 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.134990087766039 0.00103777674997171 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 0.835320684237761 1.85756253116961e-09 -0.132584613334835 0.368540743016032 MirTarget -0.331667618921103 1.07700590510387e-07 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 1.62626930622185 2.81303026159352e-11 -0.132584613334835 0.368540743016032 MirTarget -0.19681995249176 1.25142656850692e-08 NA NA NA hsa-miR-144-3p PIK3R1 -1.37061426401952 5.85913017989725e-05 -0.132584613334835 0.368540743016032 mirMAP -0.149728529455162 5.90199570068709e-09 NA NA NA hsa-miR-144-5p PIK3R1 -1.23013364182798 6.303428978396e-06 -0.132584613334835 0.368540743016032 mirMAP -0.098817410598228 0.0022563072946791 NA NA NA hsa-miR-15a-5p PIK3R1 1.07800995489566 4.32072598796529e-10 -0.132584613334835 0.368540743016032 MirTarget -0.275758710579712 2.66786829582786e-08 NA NA NA hsa-miR-15b-5p PIK3R1 0.637819606405168 0.000580041575431604 -0.132584613334835 0.368540743016032 MirTarget -0.332164490578092 8.24319047412396e-13 NA NA NA hsa-miR-16-2-3p PIK3R1 0.869267463341732 0.000785361809327569 -0.132584613334835 0.368540743016032 MirTarget -0.270797792212755 7.78030324480662e-17 NA NA NA hsa-miR-16-5p PIK3R1 0.468459442059375 0.02635007201346 -0.132584613334835 0.368540743016032 MirTarget -0.331876883174364 1.84458792077216e-16 NA NA NA hsa-miR-17-5p PIK3R1 1.57209612312313 5.10453838016207e-11 -0.132584613334835 0.368540743016032 MirTarget;TargetScan;miRNATAP -0.205461506194231 5.82189035871477e-09 NA NA NA hsa-miR-182-5p PIK3R1 1.73826081735237 5.69817940588551e-09 -0.132584613334835 0.368540743016032 miRNATAP -0.195062710695262 3.86910965362375e-12 NA NA NA hsa-miR-185-5p PIK3R1 1.20157041272762 3.03584066444936e-15 -0.132584613334835 0.368540743016032 miRNATAP -0.331680219553521 1.5899202510864e-09 NA NA NA hsa-miR-186-5p PIK3R1 0.35512789129261 0.0196931838168008 -0.132584613334835 0.368540743016032 mirMAP -0.443671404478921 5.01409205354306e-15 NA NA NA hsa-miR-188-5p PIK3R1 1.57437249320621 2.78824007819973e-08 -0.132584613334835 0.368540743016032 MirTarget -0.138656197885074 1.597564629934e-05 NA NA NA hsa-miR-200b-3p PIK3R1 2.06025765178663 3.07718049337497e-10 -0.132584613334835 0.368540743016032 mirMAP -0.190323937293919 4.94804536331339e-14 NA NA NA hsa-miR-200c-3p PIK3R1 1.74925752003763 3.42000026705311e-08 -0.132584613334835 0.368540743016032 mirMAP -0.218718536239199 3.75780637473004e-17 NA NA NA hsa-miR-20a-5p PIK3R1 1.57190995476158 8.72275528729458e-12 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.130281803040919 0.000485243379752592 NA NA NA hsa-miR-21-5p PIK3R1 2.21515015440792 6.0468197386674e-49 -0.132584613334835 0.368540743016032 miRNAWalker2_validate;MirTarget;miRNATAP -0.149170797978773 0.00275496702870304 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.810640598956005 2.08058512206955e-06 -0.132584613334835 0.368540743016032 MirTarget -0.201364520132149 9.76595689156252e-05 NA NA NA hsa-miR-22-5p PIK3R1 0.668839167786886 0.00102248931590479 -0.132584613334835 0.368540743016032 mirMAP -0.283079357243757 2.60043419499455e-11 NA NA NA hsa-miR-221-3p PIK3R1 1.11809809289021 6.56903442847056e-08 -0.132584613334835 0.368540743016032 MirTarget -0.286726960767047 2.28472885436058e-12 NA NA NA hsa-miR-222-3p PIK3R1 1.50650995841483 1.51287294049382e-09 -0.132584613334835 0.368540743016032 MirTarget -0.271001919790177 2.35665812286189e-16 NA NA NA hsa-miR-29a-3p PIK3R1 -0.235052170104117 0.138527567930958 -0.132584613334835 0.368540743016032 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.283923645063458 4.63143348819464e-07 NA NA NA hsa-miR-29b-3p PIK3R1 0.0225365195743876 0.914313337784307 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.268280450015629 1.38687845300335e-10 NA NA NA hsa-miR-29c-3p PIK3R1 -1.34143813218298 2.77493790306384e-12 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.0892904824775959 0.0483089367369576 NA NA NA hsa-miR-320a PIK3R1 0.451741078692272 0.00893327237386749 -0.132584613334835 0.368540743016032 miRNATAP -0.160922707834791 0.00201959794696513 NA NA NA hsa-miR-320b PIK3R1 1.21733873788625 7.99882585998487e-07 -0.132584613334835 0.368540743016032 miRNATAP -0.226506038658528 5.45267288733949e-11 NA NA NA hsa-miR-324-3p PIK3R1 0.903513852828114 7.41223794911022e-07 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.285021076398905 1.60294449084084e-09 NA NA NA hsa-miR-330-3p PIK3R1 0.391166748754241 0.0581284813543685 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.250685072184435 1.32131838823197e-08 NA NA NA hsa-miR-335-3p PIK3R1 2.29463721765513 4.1956113745077e-18 -0.132584613334835 0.368540743016032 mirMAP -0.0878486041364528 0.00565403499939117 NA NA NA hsa-miR-3607-3p PIK3R1 0.479939234340415 0.251616873367277 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.11392823791827 1.4389331266431e-07 NA NA NA hsa-miR-361-5p PIK3R1 0.538048008019709 1.61165802415302e-07 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.264285643241021 0.00281945473241426 NA NA NA hsa-miR-369-3p PIK3R1 0.644921905467686 0.00104986428608648 -0.132584613334835 0.368540743016032 PITA -0.175508362020099 0.000110361870932148 NA NA NA hsa-miR-374a-3p PIK3R1 0.0703956336838676 0.602396227448772 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.203181865162707 0.00271937754974667 NA NA NA hsa-miR-409-3p PIK3R1 1.02296003511803 1.54748197930307e-08 -0.132584613334835 0.368540743016032 mirMAP -0.145382126407499 0.00276980374621516 NA NA NA hsa-miR-424-5p PIK3R1 0.956135912596328 0.00035164943928494 -0.132584613334835 0.368540743016032 MirTarget -0.206889102675453 1.32836395451424e-10 NA NA NA hsa-miR-429 PIK3R1 1.58250682050303 4.75828087352234e-05 -0.132584613334835 0.368540743016032 mirMAP;miRNATAP -0.192620146255309 4.11623188242549e-19 NA NA NA hsa-miR-450b-5p PIK3R1 1.36137774989901 7.45499130609203e-11 -0.132584613334835 0.368540743016032 miRNATAP -0.127689312952549 0.00207332506528985 NA NA NA hsa-miR-455-3p PIK3R1 1.12209231899143 0.00131487017648489 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRNATAP -0.155821698046641 2.793759765901e-10 NA NA NA hsa-miR-485-3p PIK3R1 0.974132444962534 1.06350591823177e-05 -0.132584613334835 0.368540743016032 mirMAP -0.0821429244445461 0.0423162789663516 NA NA NA hsa-miR-486-5p PIK3R1 -1.52128065772506 4.50915908626354e-09 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;miRNATAP -0.111517124883819 0.000872296997974682 25475121 Mechanistically miR-486-5p was confirmed to directly target PIK3R1 expression thereby suppressing phosphatidylinositol 3-kinase-AKT pathway activation by dual luciferase reporter assay and real-time quantitative RT-PCR and western blot analysis; In addition PIK3R1 knockdown mimicked the effects of miR-486-5p overexpression by inhibiting HCC growth migration and invasion; Furthermore correlation analysis Kaplan-Meier estimates and Cox proportional hazard models showed an inverse correlation between miR-486-5p and PIK3R1 as well as a shorter time to recurrence after HCC resection in patients with lower miR-486-5p expression; Hence we conclude that miR-486-5p which is frequently downregulated in HCC inhibits HCC progression by targeting PIK3R1 and phosphatidylinositol 3-kinase-AKT activation recurrence;progression liver cancer hsa-miR-493-5p PIK3R1 1.32223598235404 3.01688809960418e-10 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.177956302441626 1.44369707660942e-05 NA NA NA hsa-miR-495-3p PIK3R1 -0.024887553302567 0.897251687801771 -0.132584613334835 0.368540743016032 mirMAP -0.112059530241924 0.0172611826398109 NA NA NA hsa-miR-532-3p PIK3R1 1.35968112631236 2.41509711096659e-06 -0.132584613334835 0.368540743016032 MirTarget -0.188788796166485 1.81630429981725e-10 NA NA NA hsa-miR-542-3p PIK3R1 1.12416854979951 1.02649534578738e-12 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda -0.124824165626404 0.0236577831714213 NA NA NA hsa-miR-582-5p PIK3R1 0.0720675907490005 0.728284850619144 -0.132584613334835 0.368540743016032 mirMAP -0.195748699479339 5.38518019551405e-06 NA NA NA hsa-miR-584-5p PIK3R1 1.67982799803889 6.57055559274014e-09 -0.132584613334835 0.368540743016032 mirMAP -0.0903881531945547 0.00263422489308543 NA NA NA hsa-miR-589-3p PIK3R1 1.00357906465313 8.20399071001461e-05 -0.132584613334835 0.368540743016032 mirMAP -0.19207222979387 1.00729738499744e-07 NA NA NA hsa-miR-590-3p PIK3R1 0.858742926831233 0.000127281269371976 -0.132584613334835 0.368540743016032 miRanda;mirMAP -0.306685343313858 4.00860799504336e-16 NA NA NA hsa-miR-590-5p PIK3R1 0.932604531809045 8.39043954167884e-05 -0.132584613334835 0.368540743016032 MirTarget;PITA;miRanda;miRNATAP -0.26961119042859 5.68457893013219e-14 NA NA NA hsa-miR-629-3p PIK3R1 0.597278340934362 0.0508108703940013 -0.132584613334835 0.368540743016032 MirTarget -0.213641933124726 1.40141884423934e-12 NA NA NA hsa-miR-654-3p PIK3R1 -0.141140644392039 0.545807044192286 -0.132584613334835 0.368540743016032 mirMAP -0.106804874473743 0.00563135914162428 NA NA NA hsa-miR-93-5p PIK3R1 1.68243825551104 4.62947431501061e-15 -0.132584613334835 0.368540743016032 MirTarget;miRNATAP -0.1664038546685 2.34893767088624e-05 NA NA NA hsa-miR-96-5p PIK3R1 1.44821155854693 6.56312590328933e-06 -0.132584613334835 0.368540743016032 TargetScan;miRNATAP -0.166674403190105 5.26906773814753e-09 NA NA NA hsa-miR-133a-3p PIK3R2 -2.63342156915404 5.72661351480585e-12 0.6802233434179 1.14371526174319e-06 miRNAWalker2_validate -0.113207314566063 1.18348525180172e-07 NA NA NA hsa-miR-30a-5p PIK3R2 -0.742755040631906 3.79943871404435e-05 0.6802233434179 1.14371526174319e-06 miRNATAP -0.254082730397951 6.3354742949341e-08 NA NA NA hsa-miR-1271-5p PIK3R3 0.174238075093354 0.430890829818199 0.229241319600778 0.105783008441893 mirMAP -0.0882149659387265 0.0294585910911095 NA NA NA hsa-miR-136-5p PIK3R3 0.501768051727903 0.0272130411225693 0.229241319600778 0.105783008441893 mirMAP -0.119545709964546 0.00163980471910892 NA NA NA hsa-miR-148b-3p PIK3R3 0.719517328390822 3.51245964668412e-05 0.229241319600778 0.105783008441893 mirMAP;miRNATAP -0.127248050375296 0.0101379445644198 24632606 Altered p53 regulation of miR 148b and p55PIK contributes to tumor progression in colorectal cancer; In this study we show that miR-148b binds specifically to the 3'-untranslated region of p55PIK and significantly suppresses p55PIK expression; MiR-148b overexpression abolished p55PIK stimulation of cell proliferation and cell cycle progression in colorectal cancer CRC cell lines and decreased tumor growth in vivo; In CRC cell lines and tissues p53 expression was associated with miR-148b expression and both were negatively associated with p55PIK expression progression colorectal cancer hsa-miR-15b-3p PIK3R3 0.811179945491507 0.000927520880593552 0.229241319600778 0.105783008441893 mirMAP -0.0705872488111892 0.0447318925510846 NA NA NA hsa-miR-182-5p PIK3R3 1.73826081735237 5.69817940588551e-09 0.229241319600778 0.105783008441893 mirMAP -0.0679364281926044 0.0157829133361992 NA NA NA hsa-miR-19a-3p PIK3R3 1.71062381299889 1.72281025366819e-11 0.229241319600778 0.105783008441893 MirTarget;miRNATAP -0.0721230917531579 0.0277760767027966 NA NA NA hsa-miR-19b-3p PIK3R3 0.936987029203338 9.28141970787798e-06 0.229241319600778 0.105783008441893 MirTarget;miRNATAP -0.109126830954357 0.00691702665683187 NA NA NA hsa-miR-222-5p PIK3R3 1.40730191326147 1.77506391601374e-06 0.229241319600778 0.105783008441893 mirMAP -0.0597998596699453 0.0412636648430192 NA NA NA hsa-miR-25-3p PIK3R3 0.948739680210032 3.62304579611938e-09 0.229241319600778 0.105783008441893 MirTarget -0.11205754710572 0.0340829353902195 NA NA NA hsa-miR-26a-5p PIK3R3 -0.507487084157331 3.23715933371269e-05 0.229241319600778 0.105783008441893 miRNATAP -0.209073335478335 0.00343291357619903 NA NA NA hsa-miR-26b-5p PIK3R3 -0.499493687076043 0.0118149973400486 0.229241319600778 0.105783008441893 miRNATAP -0.121369160993845 0.00540425919442956 NA NA NA hsa-miR-32-5p PIK3R3 0.425717775201634 0.0402079308210921 0.229241319600778 0.105783008441893 MirTarget;miRNATAP -0.153402094339603 0.000220452047926588 NA NA NA hsa-miR-331-3p PIK3R3 0.818192524829557 0.000359485856225569 0.229241319600778 0.105783008441893 miRNAWalker2_validate;PITA -0.0823804695620672 0.0281022937873429 NA NA NA hsa-miR-339-5p PIK3R3 0.51232205151031 0.0560469213103598 0.229241319600778 0.105783008441893 MirTarget;miRanda -0.0767674638981791 0.0173194092373731 NA NA NA hsa-miR-365a-3p PIK3R3 -0.801671336684825 1.28258342849568e-06 0.229241319600778 0.105783008441893 MirTarget -0.1392740113137 0.00709186083170874 NA NA NA hsa-miR-369-3p PIK3R3 0.644921905467686 0.00104986428608648 0.229241319600778 0.105783008441893 PITA -0.169433183932675 0.000105326046123099 NA NA NA hsa-miR-381-3p PIK3R3 -0.163029390855052 0.306162657669783 0.229241319600778 0.105783008441893 mirMAP -0.140900581723428 0.0104447671749475 NA NA NA hsa-miR-429 PIK3R3 1.58250682050303 4.75828087352234e-05 0.229241319600778 0.105783008441893 miRNATAP -0.0595232227405784 0.00733394108008787 NA NA NA hsa-miR-495-3p PIK3R3 -0.024887553302567 0.897251687801771 0.229241319600778 0.105783008441893 mirMAP -0.110726086516907 0.0144929938591346 NA NA NA hsa-miR-582-5p PIK3R3 0.0720675907490005 0.728284850619144 0.229241319600778 0.105783008441893 PITA -0.0966035939458665 0.0215333770678844 NA NA NA hsa-miR-590-3p PIK3R3 0.858742926831233 0.000127281269371976 0.229241319600778 0.105783008441893 PITA;mirMAP;miRNATAP -0.0879278274319683 0.0220179442326156 NA NA NA hsa-miR-590-5p PIK3R3 0.932604531809045 8.39043954167884e-05 0.229241319600778 0.105783008441893 miRanda -0.0720128822317668 0.0471089398523455 NA NA NA hsa-miR-654-3p PIK3R3 -0.141140644392039 0.545807044192286 0.229241319600778 0.105783008441893 PITA;miRNATAP -0.121763071562714 0.00100702070926152 NA NA NA hsa-miR-182-5p PIK3R5 1.73826081735237 5.69817940588551e-09 0.173685984363141 0.418027202475398 MirTarget -0.109303293886238 0.0102270829052502 NA NA NA hsa-miR-18a-3p PIK3R5 1.42489363201958 4.87914808744785e-05 0.173685984363141 0.418027202475398 MirTarget -0.103577402155963 0.0120289887456205 NA NA NA hsa-miR-142-5p PPP3CA 1.08445947321046 0.000126372881543671 0.277623917766992 0.00961281308058052 PITA;mirMAP;miRNATAP -0.072467448057027 0.00148648579012326 NA NA NA hsa-miR-145-5p PPP3CA -1.54503595327403 2.65080161523141e-09 0.277623917766992 0.00961281308058052 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0716084598901907 0.00339352251507919 NA NA NA hsa-miR-33a-3p PPP3CA 0.21453033253985 0.371591474252951 0.277623917766992 0.00961281308058052 MirTarget;mirMAP;miRNATAP -0.0713558380372273 0.0127292082855996 NA NA NA hsa-miR-3653-3p PPP3CA 0.832281812996978 0.0074838359407703 0.277623917766992 0.00961281308058052 MirTarget -0.06130989528137 0.00354671696941316 NA NA NA hsa-miR-374b-3p PPP3CA 0.286271228061054 0.169086077672581 0.277623917766992 0.00961281308058052 MirTarget -0.125486121489674 0.000113682941271975 NA NA NA hsa-miR-502-3p PPP3CA 0.989057260587538 3.37032335853725e-07 0.277623917766992 0.00961281308058052 MirTarget;PITA;miRNATAP -0.0865399741073269 0.00922939218261395 NA NA NA hsa-miR-590-5p PPP3CA 0.932604531809045 8.39043954167884e-05 0.277623917766992 0.00961281308058052 PITA;miRanda;miRNATAP -0.0699235398534225 0.0107278152577315 NA NA NA hsa-miR-99b-5p PPP3CA 0.113013581443541 0.512625439263086 0.277623917766992 0.00961281308058052 MirTarget -0.114221393713984 0.00286006149815181 NA NA NA hsa-miR-107 PPP3CB 0.85152957824299 1.22369651446858e-11 -0.422780562757183 4.51344710656914e-05 miRanda -0.288367048854735 2.92508755791905e-09 NA NA NA hsa-miR-10b-5p PPP3CB -0.2493192229845 0.144956122242922 -0.422780562757183 4.51344710656914e-05 miRNAWalker2_validate -0.100528648474207 0.0076769423338973 NA NA NA hsa-miR-140-5p PPP3CB 0.132398579631585 0.457960134430787 -0.422780562757183 4.51344710656914e-05 miRanda -0.187414441965582 1.25912301040941e-07 NA NA NA hsa-miR-146b-5p PPP3CB 2.23105707690238 3.83997814011313e-23 -0.422780562757183 4.51344710656914e-05 miRanda -0.164512260559993 6.69154707753253e-11 NA NA NA hsa-miR-15a-5p PPP3CB 1.07800995489566 4.32072598796529e-10 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.228290467215453 5.86207137940529e-11 NA NA NA hsa-miR-15b-5p PPP3CB 0.637819606405168 0.000580041575431604 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.257607887149993 3.16794050944625e-15 NA NA NA hsa-miR-16-5p PPP3CB 0.468459442059375 0.02635007201346 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.238877122232723 7.04452900892349e-17 NA NA NA hsa-miR-20a-3p PPP3CB 0.703027135708586 0.022464856696655 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.134720661118285 7.02707692910211e-11 NA NA NA hsa-miR-26a-5p PPP3CB -0.507487084157331 3.23715933371269e-05 -0.422780562757183 4.51344710656914e-05 MirTarget;miRNATAP -0.15748401777196 0.00284028972291063 NA NA NA hsa-miR-26b-5p PPP3CB -0.499493687076043 0.0118149973400486 -0.422780562757183 4.51344710656914e-05 MirTarget;miRNATAP -0.169263655449838 8.48795995650111e-08 NA NA NA hsa-miR-320a PPP3CB 0.451741078692272 0.00893327237386749 -0.422780562757183 4.51344710656914e-05 miRanda -0.074477807932897 0.0456329945042267 NA NA NA hsa-miR-320b PPP3CB 1.21733873788625 7.99882585998487e-07 -0.422780562757183 4.51344710656914e-05 miRanda -0.166916823932829 9.2484091369528e-12 NA NA NA hsa-miR-326 PPP3CB -0.552187708067123 0.039648668341622 -0.422780562757183 4.51344710656914e-05 MirTarget;PITA;miRanda -0.119889598422512 2.94925975525176e-07 NA NA NA hsa-miR-330-5p PPP3CB 0.621676971901542 0.00233177378595631 -0.422780562757183 4.51344710656914e-05 MirTarget;PITA;miRanda -0.209582580904677 2.98485755337729e-12 NA NA NA hsa-miR-339-5p PPP3CB 0.51232205151031 0.0560469213103598 -0.422780562757183 4.51344710656914e-05 miRanda -0.155934892500875 1.06748223210035e-11 NA NA NA hsa-miR-340-5p PPP3CB 0.344103676703511 0.0160638942614091 -0.422780562757183 4.51344710656914e-05 MirTarget -0.0909694812609722 0.0451520144712399 NA NA NA hsa-miR-342-3p PPP3CB 0.235422340773149 0.290471946350276 -0.422780562757183 4.51344710656914e-05 miRanda -0.104683313030798 0.000255990810106459 NA NA NA hsa-miR-361-5p PPP3CB 0.538048008019709 1.61165802415302e-07 -0.422780562757183 4.51344710656914e-05 miRanda -0.17464362517354 0.00556809094507137 NA NA NA hsa-miR-369-3p PPP3CB 0.644921905467686 0.00104986428608648 -0.422780562757183 4.51344710656914e-05 mirMAP -0.152903945305437 1.82424985009585e-06 NA NA NA hsa-miR-421 PPP3CB 1.26653675546617 2.35180826009926e-08 -0.422780562757183 4.51344710656914e-05 miRanda -0.125686484899785 4.53016255884588e-06 NA NA NA hsa-miR-424-5p PPP3CB 0.956135912596328 0.00035164943928494 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.186928116987328 5.19541271867053e-17 NA NA NA hsa-miR-429 PPP3CB 1.58250682050303 4.75828087352234e-05 -0.422780562757183 4.51344710656914e-05 miRanda -0.142621990530858 7.32416257804096e-21 NA NA NA hsa-miR-450b-5p PPP3CB 1.36137774989901 7.45499130609203e-11 -0.422780562757183 4.51344710656914e-05 MirTarget;PITA;miRNATAP -0.197124450428441 4.18667889320484e-12 NA NA NA hsa-miR-452-5p PPP3CB 0.612108901803716 0.0110020550949664 -0.422780562757183 4.51344710656914e-05 MirTarget;miRNATAP -0.0994126332387741 0.00015651063204487 NA NA NA hsa-miR-493-5p PPP3CB 1.32223598235404 3.01688809960418e-10 -0.422780562757183 4.51344710656914e-05 miRNATAP -0.145554803198721 5.21060803157266e-07 NA NA NA hsa-miR-501-5p PPP3CB 1.59306197632625 2.04856600619363e-09 -0.422780562757183 4.51344710656914e-05 PITA;miRNATAP -0.168802236162234 5.95508853838858e-13 NA NA NA hsa-miR-577 PPP3CB 0.615893340074725 0.210494450869356 -0.422780562757183 4.51344710656914e-05 mirMAP -0.0838539747281094 1.06465501112951e-09 NA NA NA hsa-miR-590-3p PPP3CB 0.858742926831233 0.000127281269371976 -0.422780562757183 4.51344710656914e-05 miRanda -0.262264024295873 5.03208562495967e-24 NA NA NA hsa-miR-7-1-3p PPP3CB 0.94398354303717 7.5771319809992e-05 -0.422780562757183 4.51344710656914e-05 mirMAP -0.211372678454912 2.41258242120576e-17 NA NA NA hsa-miR-361-5p PPP3CC 0.538048008019709 1.61165802415302e-07 -0.363869083770377 0.00921939193291838 miRanda -0.23664752091267 0.00504602062919921 NA NA NA hsa-miR-375 PPP3CC -0.348733074320394 0.47719066431766 -0.363869083770377 0.00921939193291838 miRanda -0.0672729393689476 9.78664627960404e-05 NA NA NA hsa-miR-500a-3p PPP3CC 1.51438197609577 4.33054210292228e-12 -0.363869083770377 0.00921939193291838 MirTarget;miRNATAP -0.139850016811968 0.000184052942707902 NA NA NA hsa-miR-501-3p PPP3CC 1.88467797720099 9.65178855450719e-15 -0.363869083770377 0.00921939193291838 MirTarget;PITA;miRNATAP -0.126911603513412 0.000133172429563842 NA NA NA hsa-miR-502-3p PPP3CC 0.989057260587538 3.37032335853725e-07 -0.363869083770377 0.00921939193291838 MirTarget;PITA;miRNATAP -0.141769756339311 0.00105371895784409 NA NA NA hsa-miR-101-3p PPP3R1 -0.0683272309939689 0.544163124741916 0.179231079731535 0.00243231235696175 miRNATAP -0.0839819104573581 0.0103201991439006 NA NA NA hsa-miR-1271-5p PPP3R1 0.174238075093354 0.430890829818199 0.179231079731535 0.00243231235696175 MirTarget -0.0555497494576181 0.000829288284739646 NA NA NA hsa-miR-139-5p PPP3R1 -1.41674256628297 4.51005988644234e-14 0.179231079731535 0.00243231235696175 miRanda -0.0815883532537698 5.47888817926138e-06 NA NA NA hsa-miR-143-5p PPP3R1 -0.516879359771131 0.0438729100480846 0.179231079731535 0.00243231235696175 miRNATAP -0.0602264696476564 1.17268938721146e-05 NA NA NA hsa-miR-26a-5p PPP3R1 -0.507487084157331 3.23715933371269e-05 0.179231079731535 0.00243231235696175 MirTarget;miRNATAP -0.140127759208005 1.445801018965e-06 NA NA NA hsa-miR-26b-5p PPP3R1 -0.499493687076043 0.0118149973400486 0.179231079731535 0.00243231235696175 miRNAWalker2_validate;MirTarget;miRNATAP -0.0584565801737295 0.00113092806385724 NA NA NA hsa-miR-30a-5p PPP3R1 -0.742755040631906 3.79943871404435e-05 0.179231079731535 0.00243231235696175 miRNAWalker2_validate;MirTarget;miRNATAP -0.112947134457648 3.79610942883174e-09 NA NA NA hsa-miR-130b-5p PRKACA 1.47709791778827 1.34679413565661e-06 -0.254759714806418 0.00120223663341481 mirMAP;miRNATAP -0.0719094780005917 2.99533875453077e-06 NA NA NA hsa-miR-146b-5p PRKACA 2.23105707690238 3.83997814011313e-23 -0.254759714806418 0.00120223663341481 PITA -0.101906530501573 1.08208425196835e-07 NA NA NA hsa-miR-15a-5p PRKACA 1.07800995489566 4.32072598796529e-10 -0.254759714806418 0.00120223663341481 miRNATAP -0.112153197907765 2.88199794515075e-05 NA NA NA hsa-miR-15b-5p PRKACA 0.637819606405168 0.000580041575431604 -0.254759714806418 0.00120223663341481 miRNATAP -0.130092085496616 2.92125969703536e-07 NA NA NA hsa-miR-16-5p PRKACA 0.468459442059375 0.02635007201346 -0.254759714806418 0.00120223663341481 miRNATAP -0.0819466885853533 0.000297352662490955 NA NA NA hsa-miR-185-3p PRKACA 1.38509197368746 3.93425296894499e-10 -0.254759714806418 0.00120223663341481 MirTarget -0.0805118290837543 0.000190642887480455 NA NA NA hsa-miR-2110 PRKACA 0.359318473683641 0.126104910543249 -0.254759714806418 0.00120223663341481 MirTarget -0.0869596742277026 5.25882624155771e-05 NA NA NA hsa-miR-30b-3p PRKACA 0.252088263642787 0.216818735503048 -0.254759714806418 0.00120223663341481 MirTarget -0.0534832244508962 0.0245235944048243 NA NA NA hsa-miR-532-3p PRKACA 1.35968112631236 2.41509711096659e-06 -0.254759714806418 0.00120223663341481 miRNATAP -0.0532732179904351 0.00105347024304368 NA NA NA hsa-miR-590-3p PRKACA 0.858742926831233 0.000127281269371976 -0.254759714806418 0.00120223663341481 miRanda -0.114824715780153 3.3879176865622e-08 NA NA NA hsa-miR-625-5p PRKACA 0.748754910408313 0.00783938428700196 -0.254759714806418 0.00120223663341481 MirTarget -0.0845565700502344 5.90148189721153e-07 NA NA NA hsa-miR-744-5p PRKACA 0.734924181943417 2.06706878377701e-05 -0.254759714806418 0.00120223663341481 miRNAWalker2_validate -0.0754416664714384 0.00630584103271188 NA NA NA hsa-miR-92a-1-5p PRKACA 2.04820501765632 9.32117486799495e-13 -0.254759714806418 0.00120223663341481 mirMAP -0.0668545163569544 3.42040526145234e-05 NA NA NA hsa-miR-96-5p PRKACA 1.44821155854693 6.56312590328933e-06 -0.254759714806418 0.00120223663341481 TargetScan -0.0575795726690665 0.000211208849466195 NA NA NA hsa-let-7a-3p PRKACB 0.283468597868531 0.127007787220086 -0.78544048113582 8.15272293615053e-05 MirTarget;mirMAP;miRNATAP -0.386654938607141 2.89363024981146e-09 NA NA NA hsa-let-7b-3p PRKACB 0.377956364821509 0.0061730103051373 -0.78544048113582 8.15272293615053e-05 MirTarget;mirMAP;miRNATAP -0.586928490709956 1.84163383683316e-11 NA NA NA hsa-let-7d-3p PRKACB 0.683965838350303 0.0001209895568295 -0.78544048113582 8.15272293615053e-05 MirTarget -0.540563143213791 1.15827914597495e-16 NA NA NA hsa-let-7f-1-3p PRKACB 1.09636075438131 3.42037366931931e-10 -0.78544048113582 8.15272293615053e-05 MirTarget;mirMAP -0.576273872321095 3.13340207560098e-19 NA NA NA hsa-miR-126-5p PRKACB 0.450893496822779 0.0112966412858755 -0.78544048113582 8.15272293615053e-05 mirMAP -0.397922806085586 4.46582951091209e-09 NA NA NA hsa-miR-141-3p PRKACB 1.76274853293464 9.99331900755725e-07 -0.78544048113582 8.15272293615053e-05 MirTarget;TargetScan;miRNATAP -0.256345854032607 5.98601047238794e-16 NA NA NA hsa-miR-146b-5p PRKACB 2.23105707690238 3.83997814011313e-23 -0.78544048113582 8.15272293615053e-05 miRanda -0.222335190553625 7.68995540057384e-06 NA NA NA hsa-miR-16-2-3p PRKACB 0.869267463341732 0.000785361809327569 -0.78544048113582 8.15272293615053e-05 mirMAP -0.345216491469143 1.81979508952357e-14 NA NA NA hsa-miR-17-5p PRKACB 1.57209612312313 5.10453838016207e-11 -0.78544048113582 8.15272293615053e-05 TargetScan -0.332200234149466 3.71233425032518e-12 NA NA NA hsa-miR-182-5p PRKACB 1.73826081735237 5.69817940588551e-09 -0.78544048113582 8.15272293615053e-05 MirTarget;miRNATAP -0.280078465945988 3.0310647810373e-13 NA NA NA hsa-miR-183-5p PRKACB 2.08412478942637 1.08931431254487e-10 -0.78544048113582 8.15272293615053e-05 MirTarget -0.292292744899958 3.20129643235052e-17 NA NA NA hsa-miR-18a-5p PRKACB 2.04701000113742 1.30593450319289e-12 -0.78544048113582 8.15272293615053e-05 miRNATAP -0.276164612892176 2.02423419558116e-12 NA NA NA hsa-miR-193a-3p PRKACB 0.148284355948959 0.379093889907371 -0.78544048113582 8.15272293615053e-05 miRanda -0.214876657779171 0.00364364770510541 NA NA NA hsa-miR-194-3p PRKACB 1.91477879150304 2.49480074178753e-07 -0.78544048113582 8.15272293615053e-05 MirTarget -0.211253403548211 6.3090213559711e-11 NA NA NA hsa-miR-19a-3p PRKACB 1.71062381299889 1.72281025366819e-11 -0.78544048113582 8.15272293615053e-05 MirTarget;miRNATAP -0.275437489880617 1.26516324985696e-09 NA NA NA hsa-miR-19b-3p PRKACB 0.936987029203338 9.28141970787798e-06 -0.78544048113582 8.15272293615053e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.347044836408449 5.62485948508447e-10 NA NA NA hsa-miR-200a-3p PRKACB 2.02394729844446 2.21240501925011e-08 -0.78544048113582 8.15272293615053e-05 MirTarget;miRNATAP -0.230161657673416 3.98047541676119e-13 NA NA NA hsa-miR-200b-3p PRKACB 2.06025765178663 3.07718049337497e-10 -0.78544048113582 8.15272293615053e-05 MirTarget;TargetScan -0.246879516070806 1.51468418809723e-12 NA NA NA hsa-miR-200c-3p PRKACB 1.74925752003763 3.42000026705311e-08 -0.78544048113582 8.15272293615053e-05 MirTarget;miRNATAP -0.288984018724266 7.6966325782007e-16 NA NA NA hsa-miR-2110 PRKACB 0.359318473683641 0.126104910543249 -0.78544048113582 8.15272293615053e-05 MirTarget -0.169373194336477 0.00234144535869815 NA NA NA hsa-miR-30d-3p PRKACB 0.0608340295673737 0.708110230223927 -0.78544048113582 8.15272293615053e-05 mirMAP -0.301530555109323 7.76213725274813e-05 NA NA NA hsa-miR-323a-3p PRKACB 0.308398343176418 0.29758426681013 -0.78544048113582 8.15272293615053e-05 mirMAP -0.203580453435581 2.63171092706358e-06 NA NA NA hsa-miR-330-3p PRKACB 0.391166748754241 0.0581284813543685 -0.78544048113582 8.15272293615053e-05 MirTarget -0.260830470600077 2.14091653746826e-05 NA NA NA hsa-miR-339-5p PRKACB 0.51232205151031 0.0560469213103598 -0.78544048113582 8.15272293615053e-05 miRanda -0.20526841263834 6.0588919349807e-06 NA NA NA hsa-miR-34a-5p PRKACB 0.691825068787607 0.00069818668499891 -0.78544048113582 8.15272293615053e-05 miRNATAP -0.375860755898472 1.13200739595526e-10 NA NA NA hsa-miR-361-5p PRKACB 0.538048008019709 1.61165802415302e-07 -0.78544048113582 8.15272293615053e-05 miRanda -0.366190990967506 0.00257336238284408 NA NA NA hsa-miR-362-3p PRKACB 0.994614346444282 4.39793878186399e-05 -0.78544048113582 8.15272293615053e-05 PITA;miRanda;miRNATAP -0.321219602047122 1.5030783180778e-10 NA NA NA hsa-miR-362-5p PRKACB 1.45312548529729 9.37098891085093e-09 -0.78544048113582 8.15272293615053e-05 PITA -0.274329529892276 2.80574279926103e-09 NA NA NA hsa-miR-3653-3p PRKACB 0.832281812996978 0.0074838359407703 -0.78544048113582 8.15272293615053e-05 MirTarget -0.249214432468883 8.26163586601685e-11 NA NA NA hsa-miR-370-3p PRKACB 0.890678459183993 3.22718457503803e-05 -0.78544048113582 8.15272293615053e-05 MirTarget -0.163042986494033 0.00433490677410771 NA NA NA hsa-miR-409-3p PRKACB 1.02296003511803 1.54748197930307e-08 -0.78544048113582 8.15272293615053e-05 PITA;mirMAP -0.273401572012192 3.63112252497909e-05 NA NA NA hsa-miR-421 PRKACB 1.26653675546617 2.35180826009926e-08 -0.78544048113582 8.15272293615053e-05 PITA;miRanda -0.256689079921464 1.16047269650081e-06 NA NA NA hsa-miR-429 PRKACB 1.58250682050303 4.75828087352234e-05 -0.78544048113582 8.15272293615053e-05 MirTarget;PITA;miRanda;miRNATAP -0.221632837696178 2.70031832694709e-13 NA NA NA hsa-miR-450b-5p PRKACB 1.36137774989901 7.45499130609203e-11 -0.78544048113582 8.15272293615053e-05 mirMAP -0.221653001784828 9.04313673907005e-05 NA NA NA hsa-miR-532-5p PRKACB 1.45407925817457 1.88450871132345e-14 -0.78544048113582 8.15272293615053e-05 PITA -0.476336592439424 5.04174161089628e-16 NA NA NA hsa-miR-577 PRKACB 0.615893340074725 0.210494450869356 -0.78544048113582 8.15272293615053e-05 PITA -0.169614691366841 1.42372586759292e-10 NA NA NA hsa-miR-582-5p PRKACB 0.0720675907490005 0.728284850619144 -0.78544048113582 8.15272293615053e-05 MirTarget;PITA;miRNATAP -0.154280841451621 0.009967661063768 NA NA NA hsa-miR-590-3p PRKACB 0.858742926831233 0.000127281269371976 -0.78544048113582 8.15272293615053e-05 MirTarget;PITA;miRanda;miRNATAP -0.320122146625047 1.76383529639608e-09 NA NA NA hsa-miR-590-5p PRKACB 0.932604531809045 8.39043954167884e-05 -0.78544048113582 8.15272293615053e-05 miRanda -0.344981860596061 3.62378560218264e-12 NA NA NA hsa-miR-7-1-3p PRKACB 0.94398354303717 7.5771319809992e-05 -0.78544048113582 8.15272293615053e-05 mirMAP -0.387118981958566 1.50211964600021e-15 NA NA NA hsa-miR-93-5p PRKACB 1.68243825551104 4.62947431501061e-15 -0.78544048113582 8.15272293615053e-05 miRNAWalker2_validate -0.300730482168819 1.70726962925971e-08 NA NA NA hsa-miR-96-5p PRKACB 1.44821155854693 6.56312590328933e-06 -0.78544048113582 8.15272293615053e-05 miRNATAP -0.252420090079705 8.70159560330289e-11 NA NA NA hsa-miR-107 PRKAR1A 0.85152957824299 1.22369651446858e-11 -0.0626576748573413 0.503137741080174 miRanda -0.119010539635899 0.00719622100977372 NA NA NA hsa-miR-10a-3p PRKAR1A 0.673742947104233 0.000577781470262632 -0.0626576748573413 0.503137741080174 miRNATAP -0.104990556786687 0.00033919347369295 NA NA NA hsa-miR-1296-5p PRKAR1A 0.311809599772537 0.130634669323857 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.101026388750004 0.000233049919243435 NA NA NA hsa-miR-141-3p PRKAR1A 1.76274853293464 9.99331900755725e-07 -0.0626576748573413 0.503137741080174 TargetScan -0.105190564873222 1.0602916712929e-12 NA NA NA hsa-miR-150-5p PRKAR1A 0.391701745753361 0.166399987744223 -0.0626576748573413 0.503137741080174 miRNATAP -0.064022266328769 0.00134887712871356 NA NA NA hsa-miR-155-5p PRKAR1A 0.708423342476697 0.00686702252429413 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.110018728164258 1.96566135128767e-07 NA NA NA hsa-miR-16-2-3p PRKAR1A 0.869267463341732 0.000785361809327569 -0.0626576748573413 0.503137741080174 mirMAP -0.0993656846684513 3.59220209953525e-06 NA NA NA hsa-miR-16-5p PRKAR1A 0.468459442059375 0.02635007201346 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.111196535891916 3.05520193030518e-05 NA NA NA hsa-miR-182-5p PRKAR1A 1.73826081735237 5.69817940588551e-09 -0.0626576748573413 0.503137741080174 miRNATAP -0.0869048883109974 1.71248720137755e-06 NA NA NA hsa-miR-186-5p PRKAR1A 0.35512789129261 0.0196931838168008 -0.0626576748573413 0.503137741080174 mirMAP -0.139594002262983 0.000189581761209704 NA NA NA hsa-miR-192-5p PRKAR1A 2.0867723747501 3.57854249239079e-08 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.100024379295753 7.72049910918392e-13 NA NA NA hsa-miR-200b-3p PRKAR1A 2.06025765178663 3.07718049337497e-10 -0.0626576748573413 0.503137741080174 TargetScan -0.105267398145428 7.36823437723296e-11 NA NA NA hsa-miR-215-5p PRKAR1A 1.10296552366805 0.0225256935718223 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.0722122690868502 1.56675020737221e-10 NA NA NA hsa-miR-25-3p PRKAR1A 0.948739680210032 3.62304579611938e-09 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.162890148985663 1.76283840850677e-06 NA NA NA hsa-miR-30b-5p PRKAR1A -0.0106833209203501 0.954966272944722 -0.0626576748573413 0.503137741080174 mirMAP -0.138239211575986 3.59681226501681e-06 NA NA NA hsa-miR-30e-5p PRKAR1A -0.284839730810255 0.0405852891523165 -0.0626576748573413 0.503137741080174 mirMAP -0.175074394146345 1.9440595517413e-05 NA NA NA hsa-miR-320b PRKAR1A 1.21733873788625 7.99882585998487e-07 -0.0626576748573413 0.503137741080174 miRanda -0.0845802614957088 0.000159433595573806 NA NA NA hsa-miR-324-3p PRKAR1A 0.903513852828114 7.41223794911022e-07 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate -0.102095167887496 0.000828115356516996 NA NA NA hsa-miR-429 PRKAR1A 1.58250682050303 4.75828087352234e-05 -0.0626576748573413 0.503137741080174 PITA;miRanda;miRNATAP -0.0983749193509601 2.08070393526555e-12 NA NA NA hsa-miR-577 PRKAR1A 0.615893340074725 0.210494450869356 -0.0626576748573413 0.503137741080174 PITA;mirMAP -0.0633677868818141 2.75035131535531e-07 NA NA NA hsa-miR-582-5p PRKAR1A 0.0720675907490005 0.728284850619144 -0.0626576748573413 0.503137741080174 PITA -0.0703379166374377 0.0106260424128372 NA NA NA hsa-miR-590-3p PRKAR1A 0.858742926831233 0.000127281269371976 -0.0626576748573413 0.503137741080174 miRanda;mirMAP -0.162515359522765 2.11349597147734e-11 NA NA NA hsa-miR-590-5p PRKAR1A 0.932604531809045 8.39043954167884e-05 -0.0626576748573413 0.503137741080174 miRanda -0.135961571068119 4.04026081365332e-09 NA NA NA hsa-miR-96-5p PRKAR1A 1.44821155854693 6.56312590328933e-06 -0.0626576748573413 0.503137741080174 miRNAWalker2_validate;TargetScan;miRNATAP -0.0738810371302414 5.54888367182208e-05 NA NA NA hsa-let-7a-3p PRKAR2A 0.283468597868531 0.127007787220086 -0.0807414545032392 0.4668186025327 mirMAP -0.161659819403842 7.54109498336874e-06 NA NA NA hsa-miR-106b-5p PRKAR2A 1.08518388423396 4.82746923373852e-09 -0.0807414545032392 0.4668186025327 mirMAP -0.125780469223851 0.000372666265808326 NA NA NA hsa-miR-125a-5p PRKAR2A -0.261743402170195 0.116107665196876 -0.0807414545032392 0.4668186025327 miRanda -0.121968561968733 0.0028036927272194 NA NA NA hsa-miR-140-5p PRKAR2A 0.132398579631585 0.457960134430787 -0.0807414545032392 0.4668186025327 miRanda -0.193112461013503 2.55629741944241e-07 NA NA NA hsa-miR-142-5p PRKAR2A 1.08445947321046 0.000126372881543671 -0.0807414545032392 0.4668186025327 mirMAP -0.111449201159377 1.54025797843209e-06 NA NA NA hsa-miR-146b-5p PRKAR2A 2.23105707690238 3.83997814011313e-23 -0.0807414545032392 0.4668186025327 miRanda -0.0732115465771361 0.00775576634669353 NA NA NA hsa-miR-148a-3p PRKAR2A -0.18108394434325 0.495345303586758 -0.0807414545032392 0.4668186025327 mirMAP -0.0659418478399915 0.00954705893966275 NA NA NA hsa-miR-155-5p PRKAR2A 0.708423342476697 0.00686702252429413 -0.0807414545032392 0.4668186025327 miRNAWalker2_validate -0.121994576696711 1.3205614651211e-06 NA NA NA hsa-miR-16-5p PRKAR2A 0.468459442059375 0.02635007201346 -0.0807414545032392 0.4668186025327 miRNAWalker2_validate -0.149311941864718 2.22104468677917e-06 NA NA NA hsa-miR-25-3p PRKAR2A 0.948739680210032 3.62304579611938e-09 -0.0807414545032392 0.4668186025327 mirMAP -0.109523734375075 0.00773578031894079 NA NA NA hsa-miR-26a-5p PRKAR2A -0.507487084157331 3.23715933371269e-05 -0.0807414545032392 0.4668186025327 mirMAP -0.331945495962574 9.16061681563453e-10 NA NA NA hsa-miR-26b-5p PRKAR2A -0.499493687076043 0.0118149973400486 -0.0807414545032392 0.4668186025327 mirMAP -0.203666423492688 7.25163409226595e-10 NA NA NA hsa-miR-28-5p PRKAR2A -0.22318016376076 0.0194144033008573 -0.0807414545032392 0.4668186025327 miRanda -0.174976899043156 0.0177172300041994 NA NA NA hsa-miR-29a-5p PRKAR2A 1.00715634051951 4.47499137997344e-07 -0.0807414545032392 0.4668186025327 mirMAP -0.0876457189084989 0.0083585282513373 NA NA NA hsa-miR-32-5p PRKAR2A 0.425717775201634 0.0402079308210921 -0.0807414545032392 0.4668186025327 mirMAP -0.148522128790476 3.80681198094442e-06 NA NA NA hsa-miR-320a PRKAR2A 0.451741078692272 0.00893327237386749 -0.0807414545032392 0.4668186025327 mirMAP -0.144196415384643 0.000214770128084083 NA NA NA hsa-miR-320b PRKAR2A 1.21733873788625 7.99882585998487e-07 -0.0807414545032392 0.4668186025327 mirMAP -0.0883426278007446 0.00094112287651708 NA NA NA hsa-miR-330-5p PRKAR2A 0.621676971901542 0.00233177378595631 -0.0807414545032392 0.4668186025327 miRanda -0.0930785959152363 0.00469648059539106 NA NA NA hsa-miR-335-5p PRKAR2A 0.576542642348884 0.01886326850059 -0.0807414545032392 0.4668186025327 mirMAP -0.114380892171014 2.71193375397807e-05 NA NA NA hsa-miR-342-5p PRKAR2A 0.894527325844054 0.000286684345522657 -0.0807414545032392 0.4668186025327 miRNATAP -0.120851695257259 6.26309624844235e-06 NA NA NA hsa-miR-590-5p PRKAR2A 0.932604531809045 8.39043954167884e-05 -0.0807414545032392 0.4668186025327 mirMAP -0.0936420876659915 0.000855463401174335 NA NA NA hsa-miR-628-5p PRKAR2A -0.0242002274581137 0.900266755757793 -0.0807414545032392 0.4668186025327 miRNATAP -0.0807746750312521 0.0219781349798397 NA NA NA hsa-miR-654-3p PRKAR2A -0.141140644392039 0.545807044192286 -0.0807414545032392 0.4668186025327 PITA -0.130038734173304 5.43544302744995e-06 NA NA NA hsa-miR-708-3p PRKAR2A 1.89970412556434 1.57072858438086e-13 -0.0807414545032392 0.4668186025327 mirMAP -0.077452195977977 0.00187780373814714 NA NA NA hsa-let-7a-3p PRKAR2B 0.283468597868531 0.127007787220086 -1.74491251131701 1.12121385516986e-10 mirMAP -0.513742172848187 1.58544471907167e-08 NA NA NA hsa-let-7b-3p PRKAR2B 0.377956364821509 0.0061730103051373 -1.74491251131701 1.12121385516986e-10 mirMAP -0.826805197241547 9.83802298010511e-12 NA NA NA hsa-let-7f-1-3p PRKAR2B 1.09636075438131 3.42037366931931e-10 -1.74491251131701 1.12121385516986e-10 mirMAP -0.813152396507641 8.09488530523353e-20 NA NA NA hsa-miR-107 PRKAR2B 0.85152957824299 1.22369651446858e-11 -1.74491251131701 1.12121385516986e-10 miRanda -1.18462424731695 1.25644206664059e-21 NA NA NA hsa-miR-186-5p PRKAR2B 0.35512789129261 0.0196931838168008 -1.74491251131701 1.12121385516986e-10 mirMAP -0.774989848101254 1.40970796384363e-12 NA NA NA hsa-miR-200b-3p PRKAR2B 2.06025765178663 3.07718049337497e-10 -1.74491251131701 1.12121385516986e-10 TargetScan -0.504451059563918 1.37112574474705e-28 NA NA NA hsa-miR-200c-3p PRKAR2B 1.74925752003763 3.42000026705311e-08 -1.74491251131701 1.12121385516986e-10 miRNATAP -0.547361125894443 1.34434237812676e-31 NA NA NA hsa-miR-32-5p PRKAR2B 0.425717775201634 0.0402079308210921 -1.74491251131701 1.12121385516986e-10 miRNATAP -0.545140834465151 9.0279382182593e-12 NA NA NA hsa-miR-335-3p PRKAR2B 2.29463721765513 4.1956113745077e-18 -1.74491251131701 1.12121385516986e-10 mirMAP -0.493971680187175 4.29724118194308e-18 NA NA NA hsa-miR-361-5p PRKAR2B 0.538048008019709 1.61165802415302e-07 -1.74491251131701 1.12121385516986e-10 miRanda -0.957772560998891 6.69224462042841e-09 NA NA NA hsa-miR-362-3p PRKAR2B 0.994614346444282 4.39793878186399e-05 -1.74491251131701 1.12121385516986e-10 miRanda -0.489133823407575 1.57997203472754e-12 NA NA NA hsa-miR-429 PRKAR2B 1.58250682050303 4.75828087352234e-05 -1.74491251131701 1.12121385516986e-10 PITA;miRanda;miRNATAP -0.397209747045499 1.35591726685623e-22 NA NA NA hsa-miR-450b-5p PRKAR2B 1.36137774989901 7.45499130609203e-11 -1.74491251131701 1.12121385516986e-10 mirMAP;miRNATAP -0.389219808440374 6.20053427241061e-07 NA NA NA hsa-miR-452-5p PRKAR2B 0.612108901803716 0.0110020550949664 -1.74491251131701 1.12121385516986e-10 miRNATAP -0.241339369732604 0.000655781398091681 NA NA NA hsa-miR-590-3p PRKAR2B 0.858742926831233 0.000127281269371976 -1.74491251131701 1.12121385516986e-10 miRNAWalker2_validate;miRanda -0.61298742089013 1.03382375003021e-17 NA NA NA hsa-miR-92a-3p PRKAR2B 1.06124545165614 6.51550014372282e-08 -1.74491251131701 1.12121385516986e-10 miRNATAP -0.817410635890986 1.04123239778121e-25 NA NA NA hsa-miR-92b-3p PRKAR2B 1.10163066523605 4.43024463410466e-10 -1.74491251131701 1.12121385516986e-10 miRNATAP -0.511139551577372 3.41816622951167e-08 NA NA NA hsa-miR-129-5p PRKX -1.61803714443871 4.93214379865694e-06 0.977453856340782 2.2830785601044e-08 miRanda;mirMAP -0.133604093083896 1.27028880336466e-05 NA NA NA hsa-miR-139-5p PRKX -1.41674256628297 4.51005988644234e-14 0.977453856340782 2.2830785601044e-08 MirTarget -0.226299604765045 4.42232547711776e-05 NA NA NA hsa-miR-143-5p PRKX -0.516879359771131 0.0438729100480846 0.977453856340782 2.2830785601044e-08 miRNATAP -0.128444524848598 0.00261077992482386 NA NA NA hsa-miR-145-5p PRKX -1.54503595327403 2.65080161523141e-09 0.977453856340782 2.2830785601044e-08 MirTarget;miRNATAP -0.277261417692981 2.01589373095567e-12 NA NA NA hsa-miR-195-3p PRKX -0.694544351365025 0.000214711021317786 0.977453856340782 2.2830785601044e-08 MirTarget;mirMAP -0.205719658254992 0.000396084127536688 NA NA NA hsa-miR-218-5p PRKX -0.615157868107884 0.00447149109697709 0.977453856340782 2.2830785601044e-08 miRNATAP -0.18138947195693 0.000314019565228614 NA NA NA hsa-miR-29c-3p PRKX -1.34143813218298 2.77493790306384e-12 0.977453856340782 2.2830785601044e-08 mirMAP -0.167947864092973 0.00224374802228136 NA NA NA hsa-miR-769-5p RELA 0.933922223076232 1.9485893796755e-09 -0.0416177908271402 0.538460597768655 miRNATAP -0.0642956726068968 0.0122469816565163 NA NA NA hsa-miR-664a-3p RIPK1 -0.0290482945770787 0.844010225386475 -0.248805972911612 0.000292492085392998 MirTarget -0.0607136946252186 0.0357219262513604 NA NA NA hsa-miR-129-5p TNFRSF10A -1.61803714443871 4.93214379865694e-06 0.982419247103409 9.50698554808436e-09 miRanda -0.139129219080352 3.34293193448914e-06 NA NA NA hsa-miR-145-5p TNFRSF10A -1.54503595327403 2.65080161523141e-09 0.982419247103409 9.50698554808436e-09 MirTarget -0.212840441823966 6.46325048229327e-08 NA NA NA hsa-miR-26a-5p TNFRSF10B -0.507487084157331 3.23715933371269e-05 1.22526690846357 1.76799044951707e-15 mirMAP -0.215654094996896 0.00880233395876614 NA NA NA hsa-miR-30a-5p TNFRSF10B -0.742755040631906 3.79943871404435e-05 1.22526690846357 1.76799044951707e-15 miRNAWalker2_validate -0.260390436450275 1.42305614750864e-06 NA NA NA hsa-miR-30c-2-3p TNFRSF10B -0.850499600024184 1.80492410494116e-05 1.22526690846357 1.76799044951707e-15 MirTarget -0.277443458363202 1.04292316262917e-08 NA NA NA hsa-miR-26a-5p TNFRSF10D -0.507487084157331 3.23715933371269e-05 0.254190532093899 0.215531842219704 mirMAP -0.334493909872955 0.00121266398797462 NA NA NA hsa-miR-30a-3p TNFRSF10D -1.27950866170419 4.33230022379782e-09 0.254190532093899 0.215531842219704 miRNAWalker2_validate -0.116783222411335 0.037495766565891 NA NA NA hsa-miR-129-5p TNFSF10 -1.61803714443871 4.93214379865694e-06 -0.160006459292866 0.356088332723712 miRanda -0.0970376660749457 0.00109574874848077 NA NA NA hsa-miR-361-5p TNFSF10 0.538048008019709 1.61165802415302e-07 -0.160006459292866 0.356088332723712 miRanda -0.533932463512616 1.83287538279424e-07 NA NA NA hsa-miR-125a-5p TP53 -0.261743402170195 0.116107665196876 0.511940387522054 0.00485905823274999 miRNAWalker2_validate;miRTarBase;miRanda -0.244153419981785 0.000286434605400778 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.176364454911029 0.43771853581292 0.511940387522054 0.00485905823274999 miRNAWalker2_validate;miRTarBase -0.117991649104916 0.0168993998720041 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-125b-5p XIAP -0.176364454911029 0.43771853581292 0.360481722545904 0.000466109818663069 miRNAWalker2_validate -0.0912157549380475 0.00105272007530715 NA NA NA hsa-miR-126-5p XIAP 0.450893496822779 0.0112966412858755 0.360481722545904 0.000466109818663069 mirMAP -0.179728220163487 2.9047605541146e-07 NA NA NA hsa-miR-142-5p XIAP 1.08445947321046 0.000126372881543671 0.360481722545904 0.000466109818663069 mirMAP;miRNATAP -0.0852152704452291 0.000100782852014732 NA NA NA hsa-miR-143-5p XIAP -0.516879359771131 0.0438729100480846 0.360481722545904 0.000466109818663069 mirMAP -0.085539400219972 0.00048318550061616 NA NA NA hsa-miR-149-5p XIAP -0.814305489055795 0.00575972754574164 0.360481722545904 0.000466109818663069 MirTarget -0.0774140127627732 0.000258111596946012 NA NA NA hsa-miR-155-5p XIAP 0.708423342476697 0.00686702252429413 0.360481722545904 0.000466109818663069 MirTarget -0.0899939604238558 0.000162275727792295 26779627 Bioinformatic predictions the dual-luciferase reporter assay and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein XIAP; Furthermore the results from the luciferase assays and western blot analysis identified XIAP as the direct target of miR-155; In addition introducing XIAP cDNA without a three prime untranslated region 3'-UTR rescued the miR-155 promotion of apoptosis; These results indicate that miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer cells and that miR-155 could be a potential therapeutic target to increase the efficiency of ovarian cancer interventions ovarian cancer hsa-miR-16-2-3p XIAP 0.869267463341732 0.000785361809327569 0.360481722545904 0.000466109818663069 mirMAP -0.0515372745130498 0.0338805980285385 NA NA NA hsa-miR-186-5p XIAP 0.35512789129261 0.0196931838168008 0.360481722545904 0.000466109818663069 MirTarget;miRNATAP -0.107454444158205 0.0104889867026211 NA NA NA hsa-miR-195-3p XIAP -0.694544351365025 0.000214711021317786 0.360481722545904 0.000466109818663069 mirMAP -0.112791916017921 0.000758171704526687 NA NA NA hsa-miR-2355-3p XIAP 0.101789577163865 0.693158423682028 0.360481722545904 0.000466109818663069 MirTarget;miRNATAP -0.0994533534450163 9.2843001013757e-05 NA NA NA hsa-miR-26a-2-3p XIAP 0.0619487388777404 0.765401751442771 0.360481722545904 0.000466109818663069 mirMAP -0.109489665305544 0.000407565150022559 NA NA NA hsa-miR-27a-3p XIAP 0.523219911315699 0.000116410279757859 0.360481722545904 0.000466109818663069 miRNATAP -0.095597436869067 0.0420031635634158 26662313 miR 27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK SMAC/DIABLO XIAP axis; After further investigation we indicated that the knockdown of miR-27a promoted the apoptosis via mitochondrial pathway in T-47D cells treated with CDDP depending on the BAK-second mitochondria-derived activator of caspase/direct IAP binding protein with low pI SMAC/DIABLO-X-linked inhibitor of apoptosis XIAP axis breast cancer hsa-miR-27b-3p XIAP -0.439806942644624 0.000523870009254693 0.360481722545904 0.000466109818663069 miRNATAP -0.202588585920519 5.22139927748981e-05 NA NA NA hsa-miR-28-3p XIAP -0.247525872199168 0.0399632425440147 0.360481722545904 0.000466109818663069 mirMAP;miRNATAP -0.234882736325538 9.76761720503311e-06 NA NA NA hsa-miR-32-5p XIAP 0.425717775201634 0.0402079308210921 0.360481722545904 0.000466109818663069 mirMAP -0.0834860861433266 0.0062599966528344 NA NA NA hsa-miR-320a XIAP 0.451741078692272 0.00893327237386749 0.360481722545904 0.000466109818663069 MirTarget;miRanda;miRNATAP -0.119827469771389 0.00107599031986592 NA NA NA hsa-miR-320b XIAP 1.21733873788625 7.99882585998487e-07 0.360481722545904 0.000466109818663069 MirTarget;miRanda;miRNATAP -0.051388488903082 0.0415263523504463 NA NA NA hsa-miR-330-3p XIAP 0.391166748754241 0.0581284813543685 0.360481722545904 0.000466109818663069 mirMAP;miRNATAP -0.0708634228748067 0.0261119961785451 NA NA NA hsa-miR-337-3p XIAP -0.228166532308969 0.303588587461454 0.360481722545904 0.000466109818663069 mirMAP -0.181820020262956 5.05762824121871e-11 NA NA NA hsa-miR-33a-3p XIAP 0.21453033253985 0.371591474252951 0.360481722545904 0.000466109818663069 mirMAP -0.117809683314848 1.62665913670232e-05 NA NA NA hsa-miR-3607-3p XIAP 0.479939234340415 0.251616873367277 0.360481722545904 0.000466109818663069 mirMAP -0.0681220181814252 9.19143224887896e-06 NA NA NA hsa-miR-363-3p XIAP -0.813820017118275 0.00185120318630231 0.360481722545904 0.000466109818663069 mirMAP -0.0774553269870754 0.00141635366790726 NA NA NA hsa-miR-374a-3p XIAP 0.0703956336838676 0.602396227448772 0.360481722545904 0.000466109818663069 mirMAP -0.174955939545917 0.000230074562849646 NA NA NA hsa-miR-377-5p XIAP 0.106186674263511 0.636077709551224 0.360481722545904 0.000466109818663069 mirMAP -0.0844727194636911 0.00332698514246648 NA NA NA hsa-miR-455-3p XIAP 1.12209231899143 0.00131487017648489 0.360481722545904 0.000466109818663069 miRNATAP -0.0550516070026074 0.0020807435945815 NA NA NA hsa-miR-484 XIAP 0.401753773460753 0.0490851523101605 0.360481722545904 0.000466109818663069 mirMAP -0.0831172160057233 0.0074668300704802 NA NA NA hsa-miR-505-3p XIAP 0.68973424635459 0.00225185811813183 0.360481722545904 0.000466109818663069 mirMAP -0.074894364651453 0.00724785699865421 NA NA NA hsa-miR-590-3p XIAP 0.858742926831233 0.000127281269371976 0.360481722545904 0.000466109818663069 MirTarget;miRanda;mirMAP -0.0640405124967988 0.0225412363462531 NA NA NA hsa-miR-766-3p XIAP 0.168886051269712 0.412950041105629 0.360481722545904 0.000466109818663069 mirMAP -0.118452275630115 0.000108857050425117 NA NA NA hsa-miR-940 XIAP 1.3080677738253 2.0056085433599e-05 0.360481722545904 0.000466109818663069 miRNATAP -0.0789675435850711 0.000137552256365986 NA NA NA