miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-125a-3p	PTEN	0.0421018120351819	0.828536897362692	-0.137952397656923	0.790399932547467	miRanda	-0.523147997042083	0.000306134717518573		NA	NA	NA
hsa-miR-130b-3p	PTEN	0.132315940381007	0.493405968049383	-0.137952397656923	0.790399932547467	MirTarget;miRNATAP	-0.524693700152285	0.00407683561175136	26837847;25637514	The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC	cell migration;	bladder cancer;esophageal cancer
hsa-miR-141-3p	PTEN	0.0876176827743183	0.713330783335205	-0.137952397656923	0.790399932547467	miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP	-1.12590873288236	0.00135102978984547	27644195;24742567	Involvement of microRNA 141 3p in 5 fluorouracil and oxaliplatin chemo resistance in esophageal cancer cells via regulation of PTEN; Western blot exhibited altered protein levels of PTEN Akt and PI3k with miR-141-3p inhibitor; An inverse correlation between PTEN expression and miR-141-3p expression was also observed in tissue samples; Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis	drug resistance;tumorigenesis	esophageal cancer;endometrial cancer
hsa-miR-150-3p	PTEN	0.137485769878551	0.491385513649863	-0.137952397656923	0.790399932547467	mirMAP	-0.654952169543694	9.84240362480083e-05		NA	NA	NA
hsa-miR-188-5p	PTEN	0.0609097731203252	0.76468365583222	-0.137952397656923	0.790399932547467	MirTarget;PITA;miRNATAP	-0.835887327948619	4.97650298321986e-06		NA	NA	NA
hsa-miR-198	PTEN	0.157432820899836	0.358560016187225	-0.137952397656923	0.790399932547467	MirTarget;PITA	-0.222532986447461	0.00927859483927032		NA	NA	NA
hsa-miR-30d-3p	PTEN	0.00563114047286351	0.972497504517159	-0.137952397656923	0.790399932547467	MirTarget;miRNATAP	-0.380424749887071	0.000668870604760101		NA	NA	NA
hsa-miR-30d-5p	PTEN	0.00542445946171988	0.981040986039794	-0.137952397656923	0.790399932547467	mirMAP	-0.931913982583232	0.00733367802668371		NA	NA	NA
hsa-miR-486-5p	PTEN	0.149575186044443	0.412987297310638	-0.137952397656923	0.790399932547467	MirTarget;PITA;miRanda;miRNATAP	-0.323942840327652	0.000927284585602903		NA	NA	NA
hsa-miR-494-3p	PTEN	0.0551439608387465	0.80596943857757	-0.137952397656923	0.790399932547467	miRNAWalker2_validate;miRTarBase;MirTarget	-0.838771668653121	7.06137225728937e-07	25861022;26045065;25662849;26040900;25738254	Expression and clinical evidence of miR 494 and PTEN in non small cell lung cancer; The aim of this study was to explore the expression and clinical significance of miR-494 and PTEN phosphatase and tensin homologue deleted on chromosome ten in non-small cell lung cancer NSCLC; Immunohistochemistry for PTEN and in situ hybridization ISH for miR-494 were performed in 92 NSCLC tissues and 10 normal lung tissues to detect their expression and correlation between their expression with clinical characteristics and prognosis was analyzed; The positive expression of PTEN protein in the lung carcinoma tissues was significantly lower than that in the normal lung tissues P = 0.013 while the level of miR-494 expression was negatively correlated with PTEN expression r = -0.577 P < 0.01; Patients with over-expression of miR-494 had a shorter overall survival OS while the negative group of PTEN was correlated with poor OS; MiR-494 over-expression and low PTEN expression are closely related to tumor p-TNM staging and lymph node metastasis differentiation and OS; Combined detection of PTEN and miR-494 can aid in determining malignancy degree and the prognosis of patients with NSCLC;miR 494 promotes cell proliferation migration and invasion and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN; Mechanistic investigations revealed that miR-494 suppressed the expression of PTEN but increased the expression of PI3K and p-Akt which contribute to the promotion of proliferation migration and invasion and increased sorafenib resistance to HCC cell lines;Quantitative reverse transcription PCR and Western blotting analysis revealed that the expression of PTEN was increased after downexpression of miR-494-3p in glioma cells U87 and U251 miR-494-3p inhibitor could prevent migration invasion proliferation and promote apotosis in gliomas through PTEN/AKT pathway;The angiogenic effect of miR-494 was mediated by the targeting of PTEN and the subsequent activation of Akt/eNOS pathway;MicroRNA 494 promotes cervical cancer proliferation through the regulation of PTEN; In the present study we analyzed the expression of miR-494 in -with PTEN expression and clinicopathological data of cervical cancer patients; miR-494 upregulation was significantly associated with PTEN downregulation adverse clinicopathological characteristics poor overall and progression-free survival and poor prognosis; In vitro experiments showed that inhibition of miR-494 suppressed cell proliferation and growth by directly targeting the 3'-untranslated region 3'-UTR of PTEN mRNA	worse prognosis;poor survival;staging;metastasis;differentiation;drug resistance;;;progression;worse prognosis;poor survival	lung squamous cell cancer;liver cancer;glioblastoma;lung squamous cell cancer;cervical and endocervical cancer
hsa-miR-548c-3p	PTEN	1.2112773628139	3.2469081522247e-05	-0.137952397656923	0.790399932547467	PITA;mirMAP	-0.0712070047358354	0.00185042313286142		NA	NA	NA
hsa-miR-622	PTEN	0.176363570210428	0.331275195879571	-0.137952397656923	0.790399932547467	PITA;miRNATAP	-0.428806995095189	1.72640891044879e-05		NA	NA	NA
hsa-miR-631	PTEN	-0.0759379269923754	0.668639201378677	-0.137952397656923	0.790399932547467	PITA	-0.260741674937313	0.00250528651373235		NA	NA	NA
hsa-miR-92b-3p	PTEN	-0.239533108739229	0.110556786475936	-0.137952397656923	0.790399932547467	MirTarget;miRNATAP	-0.238284048802248	0.000785105586828856	24099768;26878388;24137349;23546593	MiR 92b regulates the cell growth cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN; Furthermore we found miR-92b could directly target PTEN a unique tumor suppressor gene which was downregulated in lung cancer tissues compared to the matched adjacent normal tissues;We revealed that patients exhibiting an upregulation of hsa-miR-92b and patients with deletions of PTEN did not tend to overlap and hsa-miR-92b and PTEN coordinately regulated the pathway of 'cell cycle' and so on;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC	;;;worse prognosis	lung squamous cell cancer;breast cancer;cervical and endocervical cancer;liver cancer