miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-3p AKT3 1.36706429551147 4.60388403547821e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.150903286752378 0.0102655088674849 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-28-3p AKT3 0.387144500601444 0.00777919765254534 -1.44031241124732 2.576504600149e-09 miRNATAP -0.197315516871575 0.0122556173898666 NA NA NA hsa-miR-29a-3p AKT3 0.101650412194573 0.573201097011668 -1.44031241124732 2.576504600149e-09 miRNATAP -0.147280324253872 0.0201558550795979 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-335-3p AKT3 1.51116383169018 6.88553098788624e-13 -1.44031241124732 2.576504600149e-09 mirMAP -0.134576700675304 0.0106735082003925 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-199a-5p BRAF 1.3057193856884 2.38429382751645e-08 0.430269646481455 0.00362923920939546 miRanda -0.126145320292071 1.03462729304979e-05 NA NA NA hsa-miR-199b-5p BRAF 2.13822205171062 4.56262988762436e-15 0.430269646481455 0.00362923920939546 miRanda -0.109868089750526 5.08266642121306e-06 NA NA NA hsa-miR-103a-3p CAB39 0.538497806383155 1.88134691850591e-05 -0.111589557545997 0.30508166636484 MirTarget;miRNATAP -0.173680787255 1.25032794320303e-05 NA NA NA hsa-miR-15a-5p CAB39 1.62575353599172 1.55312121019827e-19 -0.111589557545997 0.30508166636484 miRNATAP -0.101759904439558 0.00013517775615399 NA NA NA hsa-miR-19a-3p CAB39 2.11776595911517 7.07663078397156e-10 -0.111589557545997 0.30508166636484 MirTarget;miRNATAP -0.115645777732563 3.81224400609025e-12 NA NA NA hsa-miR-19b-3p CAB39 2.10868505662119 5.40846613768389e-17 -0.111589557545997 0.30508166636484 MirTarget;miRNATAP -0.118944642545952 2.18922019242203e-09 NA NA NA hsa-miR-425-5p CAB39 1.21659524959201 8.01126418494715e-09 -0.111589557545997 0.30508166636484 MirTarget -0.127856697329723 2.92070429617044e-08 NA NA NA hsa-miR-155-5p CAB39L 0.813513839059142 0.000608282725633232 -1.66465107247543 4.53321399000615e-18 miRNAWalker2_validate -0.155667027343883 5.10115593257427e-05 NA NA NA hsa-miR-214-5p CAB39L 0.722336234279023 0.00539148054719041 -1.66465107247543 4.53321399000615e-18 MirTarget -0.108080657963591 0.00220211312386044 NA NA NA hsa-miR-590-5p CAB39L 2.07441240363458 4.95240551694843e-14 -1.66465107247543 4.53321399000615e-18 miRanda -0.194534623462582 1.13301876593688e-06 NA NA NA hsa-miR-7-1-3p CAB39L 2.61364240402652 1.98959237815786e-32 -1.66465107247543 4.53321399000615e-18 mirMAP -0.160130002550016 8.86669876951463e-05 NA NA NA hsa-miR-200b-3p DDIT4 1.55157578247391 4.83790020897188e-09 0.609442593082457 0.0294103027780334 TargetScan -0.132037769752402 0.00585924919175337 NA NA NA hsa-miR-30b-5p DDIT4 0.358144314839612 0.138026229059594 0.609442593082457 0.0294103027780334 MirTarget -0.253423928849264 1.8471251894146e-06 NA NA NA hsa-miR-30c-5p DDIT4 -0.327319105755825 0.123595832152687 0.609442593082457 0.0294103027780334 MirTarget;miRNATAP -0.174806583437269 0.00411913749737013 NA NA NA hsa-miR-30d-5p DDIT4 -0.920901858717441 3.50898334321668e-05 0.609442593082457 0.0294103027780334 MirTarget;miRNATAP -0.316533147993562 2.81465814845051e-08 NA NA NA hsa-miR-30e-5p DDIT4 1.60414100786743 3.78951090573667e-19 0.609442593082457 0.0294103027780334 MirTarget -0.164222508708412 0.0183074258630759 NA NA NA hsa-miR-32-5p DDIT4 0.876853679269853 6.04859399018691e-05 0.609442593082457 0.0294103027780334 miRNATAP -0.2376127213456 0.000188969310362304 NA NA NA hsa-miR-429 DDIT4 2.3794516574089 1.72813419703734e-13 0.609442593082457 0.0294103027780334 miRanda;miRNATAP -0.103048110324502 0.0146241344822311 NA NA NA hsa-miR-92b-3p DDIT4 0.0478787637665503 0.831716894621477 0.609442593082457 0.0294103027780334 miRNATAP -0.176763468290616 0.00209915470212765 NA NA NA hsa-miR-103a-3p EIF4B 0.538497806383155 1.88134691850591e-05 -0.221574072071826 0.0707566183691306 MirTarget;miRNATAP -0.128801163927682 0.00435534261148103 NA NA NA hsa-miR-149-5p EIF4B -0.185943525121015 0.638713382556459 -0.221574072071826 0.0707566183691306 miRNAWalker2_validate;miRNATAP -0.100028705166955 5.70531722662773e-13 NA NA NA hsa-miR-15a-5p EIF4B 1.62575353599172 1.55312121019827e-19 -0.221574072071826 0.0707566183691306 miRNATAP -0.14029195221406 2.92115496234136e-06 NA NA NA hsa-miR-185-5p EIF4B 1.14291034858482 2.95777119743491e-13 -0.221574072071826 0.0707566183691306 MirTarget -0.155606517815325 9.39735635364883e-06 NA NA NA hsa-miR-193a-3p EIF4B 0.549173467360291 0.0319030569365466 -0.221574072071826 0.0707566183691306 miRanda -0.120575433874547 3.45124934422834e-07 NA NA NA hsa-miR-339-5p EIF4B 0.536997313601114 0.0488090394176611 -0.221574072071826 0.0707566183691306 miRanda -0.141142891711417 2.89072252600077e-12 NA NA NA hsa-miR-342-3p EIF4B -0.128691966564961 0.561034080130801 -0.221574072071826 0.0707566183691306 miRanda -0.160390481197487 1.65242391839946e-10 NA NA NA hsa-miR-423-3p EIF4B 0.237880985943445 0.221744070846278 -0.221574072071826 0.0707566183691306 miRNAWalker2_validate -0.137900850810487 1.76527684792325e-06 NA NA NA hsa-miR-139-5p EIF4E -2.26625553116965 7.22375119369519e-16 0.139971135571262 0.21378211756024 miRanda -0.105305471908209 1.82604906028467e-09 NA NA NA hsa-miR-145-5p EIF4E -1.34926078156437 2.63526538800669e-07 0.139971135571262 0.21378211756024 miRNAWalker2_validate;miRTarBase -0.118124217842371 6.90276986338154e-10 NA NA NA hsa-miR-195-3p EIF4E -1.33068822339418 6.65427393047357e-09 0.139971135571262 0.21378211756024 mirMAP -0.133161051232494 1.22059953709548e-09 NA NA NA hsa-miR-30b-5p EIF4E 0.358144314839612 0.138026229059594 0.139971135571262 0.21378211756024 mirMAP -0.121203139100493 9.7504708381074e-09 NA NA NA hsa-miR-30c-5p EIF4E -0.327319105755825 0.123595832152687 0.139971135571262 0.21378211756024 mirMAP -0.209994080917116 3.50641549814748e-19 NA NA NA hsa-miR-30d-3p EIF4E 0.00396376345349925 0.986457040013182 0.139971135571262 0.21378211756024 mirMAP -0.10809245113846 1.22707687519464e-05 NA NA NA hsa-miR-320a EIF4E -0.961144925954715 1.62478794429204e-08 0.139971135571262 0.21378211756024 MirTarget;miRanda -0.137912541912181 3.91843747814961e-06 NA NA NA hsa-miR-500a-5p EIF4E 0.648155655714409 0.0104657432932038 0.139971135571262 0.21378211756024 mirMAP -0.10079306749408 1.19064139391264e-06 NA NA NA hsa-miR-125a-5p EIF4EBP1 -1.04824536696301 3.97386082850476e-07 1.23820184181367 2.37941726971645e-06 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.263609655673837 5.92442887758411e-06 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125b-5p EIF4EBP1 -0.548859243919575 0.0107224406584463 1.23820184181367 2.37941726971645e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144470531138159 0.0111295608531489 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-146b-3p EIF4EBP1 -0.808296168180355 0.000870284326590347 1.23820184181367 2.37941726971645e-06 miRNATAP -0.138363451576497 0.0058330130369118 NA NA NA hsa-miR-139-5p HIF1A -2.26625553116965 7.22375119369519e-16 0.422505281196834 0.0152617112253897 miRanda -0.122564563299348 8.1506141505756e-06 NA NA NA hsa-miR-195-3p HIF1A -1.33068822339418 6.65427393047357e-09 0.422505281196834 0.0152617112253897 MirTarget -0.137979401596716 6.21077876397983e-05 NA NA NA hsa-miR-320a HIF1A -0.961144925954715 1.62478794429204e-08 0.422505281196834 0.0152617112253897 miRanda -0.127052364615254 0.00664809963558903 NA NA NA hsa-miR-660-5p HIF1A 2.04875198906126 1.08269480928897e-17 0.422505281196834 0.0152617112253897 MirTarget -0.156926827151883 1.94441532644232e-06 NA NA NA hsa-miR-130a-3p IGF1 0.881660100597014 0.000158893668519248 -0.878839289406132 0.00545024687919024 MirTarget -0.137360175720236 0.0278198372780902 NA NA NA hsa-miR-130b-3p IGF1 1.83046548750752 5.04753914574694e-13 -0.878839289406132 0.00545024687919024 MirTarget -0.208984208427567 0.000411905460472152 NA NA NA hsa-miR-15b-3p IGF1 0.804736041893915 0.000400279611457186 -0.878839289406132 0.00545024687919024 mirMAP -0.294250039955051 1.19648006053704e-05 NA NA NA hsa-miR-16-1-3p IGF1 1.50034693398929 6.63958242991125e-10 -0.878839289406132 0.00545024687919024 mirMAP -0.346697103874593 2.00512825999278e-06 NA NA NA hsa-miR-181b-5p IGF1 0.668793269169928 0.000239998092406404 -0.878839289406132 0.00545024687919024 mirMAP -0.277079678771502 0.000542842928980559 NA NA NA hsa-miR-186-5p IGF1 0.852175445703945 6.88885738584309e-10 -0.878839289406132 0.00545024687919024 mirMAP -0.579822063247168 2.4486690275545e-08 NA NA NA hsa-miR-19a-3p IGF1 2.11776595911517 7.07663078397156e-10 -0.878839289406132 0.00545024687919024 MirTarget -0.295619339516778 1.77416468047122e-09 NA NA NA hsa-miR-19b-1-5p IGF1 1.71217036351784 3.28561659177495e-12 -0.878839289406132 0.00545024687919024 mirMAP -0.353413690663535 1.05429610809513e-07 NA NA NA hsa-miR-19b-3p IGF1 2.10868505662119 5.40846613768389e-17 -0.878839289406132 0.00545024687919024 MirTarget -0.332913498199372 1.17742302735622e-08 NA NA NA hsa-miR-20a-3p IGF1 2.51803599558247 4.92479325298629e-13 -0.878839289406132 0.00545024687919024 mirMAP -0.27191171788815 1.96054552687628e-07 NA NA NA hsa-miR-26b-5p IGF1 0.72362441215247 4.7794659748036e-05 -0.878839289406132 0.00545024687919024 mirMAP -0.268812581966602 0.00103479699566484 NA NA NA hsa-miR-29b-3p IGF1 3.10527711861309 3.01242507282711e-32 -0.878839289406132 0.00545024687919024 MirTarget -0.214642092755044 3.159014552534e-05 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.70198002906399 1.56420889710984e-14 -0.878839289406132 0.00545024687919024 MirTarget -0.262923939050952 1.05879075346237e-07 NA NA NA hsa-miR-3065-5p IGF1 0.653308707552535 0.0999497219778851 -0.878839289406132 0.00545024687919024 mirMAP -0.125233094164205 0.00171064732391524 NA NA NA hsa-miR-361-5p IGF1 0.21454431962475 0.0800957579368424 -0.878839289406132 0.00545024687919024 PITA;mirMAP -0.259580395383156 0.0330038273746438 NA NA NA hsa-miR-362-5p IGF1 0.658947634569393 0.0243306847205756 -0.878839289406132 0.00545024687919024 mirMAP -0.262372836237127 2.21880393042342e-07 NA NA NA hsa-miR-421 IGF1 0.170525317701774 0.535277026680289 -0.878839289406132 0.00545024687919024 PITA -0.124950123530714 0.0309856829172305 NA NA NA hsa-miR-450b-5p IGF1 1.69248953402469 1.96052058003353e-07 -0.878839289406132 0.00545024687919024 MirTarget;PITA;mirMAP;miRNATAP -0.155478745947113 0.00168638246971297 NA NA NA hsa-miR-454-3p IGF1 1.49453641052169 4.46235742871434e-09 -0.878839289406132 0.00545024687919024 MirTarget -0.353703568576877 1.23901415685651e-07 NA NA NA hsa-miR-576-5p IGF1 1.02693643167056 1.14846964470173e-06 -0.878839289406132 0.00545024687919024 PITA;mirMAP;miRNATAP -0.319877018116458 2.70279102064343e-06 NA NA NA hsa-miR-590-3p IGF1 0.83851360565783 0.00129224433453587 -0.878839289406132 0.00545024687919024 MirTarget;miRanda;mirMAP;miRNATAP -0.218208367579052 0.00112544995000528 NA NA NA hsa-miR-629-5p IGF1 1.31657090341737 1.45711558652127e-12 -0.878839289406132 0.00545024687919024 mirMAP -0.206791424784461 0.0072984659842286 NA NA NA hsa-miR-130a-3p MAPK1 0.881660100597014 0.000158893668519248 -0.313704159534906 0.0065740365500908 mirMAP -0.101872197195 5.97373126035408e-06 NA NA NA hsa-miR-140-5p MAPK1 0.669142684153918 0.000335928403032308 -0.313704159534906 0.0065740365500908 miRanda -0.105360739553965 0.000299450445528468 NA NA NA hsa-miR-148a-3p MAPK1 2.30885799126944 1.95226081368985e-21 -0.313704159534906 0.0065740365500908 mirMAP -0.102558880400122 7.51166113357563e-07 NA NA NA hsa-miR-24-1-5p MAPK1 0.856025727237819 0.000107354490323658 -0.313704159534906 0.0065740365500908 mirMAP -0.114103342147363 5.37066958548902e-06 NA NA NA hsa-miR-29a-5p MAPK1 1.89519956688438 1.03453349363915e-11 -0.313704159534906 0.0065740365500908 mirMAP -0.100646824836984 5.49015969248301e-06 NA NA NA hsa-miR-29b-3p MAPK1 3.10527711861309 3.01242507282711e-32 -0.313704159534906 0.0065740365500908 mirMAP -0.122356815748067 3.56933939779318e-11 NA NA NA hsa-miR-342-3p MAPK1 -0.128691966564961 0.561034080130801 -0.313704159534906 0.0065740365500908 miRanda;mirMAP -0.137175460423021 7.76879946497687e-09 NA NA NA hsa-miR-34a-5p MAPK1 1.40588612517769 8.60097477768592e-12 -0.313704159534906 0.0065740365500908 mirMAP -0.105828142272272 2.59913448288353e-05 NA NA NA hsa-miR-454-3p MAPK1 1.49453641052169 4.46235742871434e-09 -0.313704159534906 0.0065740365500908 mirMAP -0.104171229052281 2.01455003951624e-05 NA NA NA hsa-miR-106b-5p PDPK1 1.47447672652218 1.32004094930462e-13 -0.26368366292376 0.0340750618656775 mirMAP -0.132983936439965 1.77593247426353e-06 NA NA NA hsa-miR-128-3p PDPK1 1.03509868349735 2.11606310588315e-10 -0.26368366292376 0.0340750618656775 miRNAWalker2_validate -0.161462495530987 2.76676989700492e-06 NA NA NA hsa-miR-16-5p PDPK1 0.749619098384047 4.11649450706988e-06 -0.26368366292376 0.0340750618656775 mirMAP -0.118430790715905 0.000724062980260007 NA NA NA hsa-miR-17-5p PDPK1 2.07078488653279 2.77403038572568e-19 -0.26368366292376 0.0340750618656775 miRNAWalker2_validate;mirMAP -0.107136721665695 6.10449319550876e-06 NA NA NA hsa-miR-185-5p PDPK1 1.14291034858482 2.95777119743491e-13 -0.26368366292376 0.0340750618656775 miRNAWalker2_validate -0.11248642658292 0.00170480215738574 NA NA NA hsa-miR-186-5p PDPK1 0.852175445703945 6.88885738584309e-10 -0.26368366292376 0.0340750618656775 mirMAP -0.108329789684716 0.00858347542158776 NA NA NA hsa-miR-22-5p PDPK1 1.71436244278242 9.85038001236064e-15 -0.26368366292376 0.0340750618656775 miRNATAP -0.123784892781515 6.63771805008179e-07 NA NA NA hsa-miR-421 PDPK1 0.170525317701774 0.535277026680289 -0.26368366292376 0.0340750618656775 mirMAP -0.125807153434679 1.79847351270783e-08 NA NA NA hsa-miR-424-5p PDPK1 1.26485330287919 6.1498991028257e-06 -0.26368366292376 0.0340750618656775 mirMAP -0.113642048263266 1.31038105937281e-08 NA NA NA hsa-miR-590-3p PDPK1 0.83851360565783 0.00129224433453587 -0.26368366292376 0.0340750618656775 miRanda;miRNATAP -0.148018696489024 1.11768793717628e-08 NA NA NA hsa-miR-590-5p PDPK1 2.07441240363458 4.95240551694843e-14 -0.26368366292376 0.0340750618656775 miRanda -0.141789138582833 1.02205671237423e-08 NA NA NA hsa-miR-146b-5p PGF 1.0922867893808 5.63754607494775e-06 0.777631755389818 0.00433016067358226 miRanda -0.123674254078055 0.0173831758596673 NA NA NA hsa-miR-335-5p PGF -0.466533891325811 0.0676987038122831 0.777631755389818 0.00433016067358226 miRNATAP -0.119665162525165 0.0306179315192342 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-148b-3p PIK3CG 0.483970528590224 0.0026495409465901 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.239430332797948 0.00515332606189168 NA NA NA hsa-miR-26b-5p PIK3CG 0.72362441215247 4.7794659748036e-05 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.285401672500096 0.000198071700272844 NA NA NA hsa-miR-29b-3p PIK3CG 3.10527711861309 3.01242507282711e-32 -1.19325793461087 5.28114748039233e-05 miRTarBase -0.13454994451672 0.00563635188925694 NA NA NA hsa-miR-335-3p PIK3CG 1.51116383169018 6.88553098788624e-13 -1.19325793461087 5.28114748039233e-05 mirMAP -0.273824058387904 1.51960031354635e-05 NA NA NA hsa-miR-542-3p PIK3CG 1.62226640768239 2.6427102465476e-10 -1.19325793461087 5.28114748039233e-05 miRanda -0.188110029792226 0.000315799878113487 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-107 PIK3R1 0.658676029898313 5.11480446318819e-07 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.134608742116129 0.0261488734968106 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-107 PIK3R5 0.658676029898313 5.11480446318819e-07 -1.41857329052665 4.9150449517908e-09 miRanda -0.303365993068523 0.000471196296141979 NA NA NA hsa-miR-182-5p PIK3R5 3.21839823004635 5.13049145201115e-39 -1.41857329052665 4.9150449517908e-09 MirTarget -0.327566926397612 1.58877421029473e-15 NA NA NA hsa-miR-130a-3p PRKAA1 0.881660100597014 0.000158893668519248 0.176948925816615 0.18584938395102 MirTarget;miRNATAP -0.134550408690526 2.13547664400238e-07 NA NA NA hsa-miR-146b-3p PRKAA1 -0.808296168180355 0.000870284326590347 0.176948925816615 0.18584938395102 MirTarget;PITA;miRNATAP -0.138287966858846 2.87259056315393e-08 NA NA NA hsa-miR-15a-5p PRKAA1 1.62575353599172 1.55312121019827e-19 0.176948925816615 0.18584938395102 MirTarget -0.139498587712748 2.0938212928926e-05 NA NA NA hsa-miR-15b-5p PRKAA1 -1.25935038177398 1.83460220856901e-12 0.176948925816615 0.18584938395102 MirTarget -0.105815453966907 0.00169246229615882 NA NA NA hsa-miR-497-5p PRKAA1 -0.0546347378264729 0.786205564901684 0.176948925816615 0.18584938395102 MirTarget -0.127996624125465 2.72701958097883e-05 NA NA NA hsa-let-7a-5p PRKAA2 -1.37014061604018 3.11451492971224e-14 0.538393374272207 0.161947097377576 MirTarget;TargetScan -0.24379808574527 0.011233777003514 NA NA NA hsa-let-7b-3p PRKAA2 -1.81889978084306 6.9913416210266e-19 0.538393374272207 0.161947097377576 mirMAP -0.240523717163737 0.00394798493434319 NA NA NA hsa-let-7b-5p PRKAA2 -1.62016148171663 1.56547487335694e-15 0.538393374272207 0.161947097377576 miRNAWalker2_validate;MirTarget -0.271771541704824 0.0013415232460047 NA NA NA hsa-let-7c-5p PRKAA2 -2.14139413005852 1.66416999341685e-18 0.538393374272207 0.161947097377576 MirTarget -0.193073682628501 0.00583564514868253 NA NA NA hsa-let-7i-5p PRKAA2 0.605080599172936 1.48406814653206e-06 0.538393374272207 0.161947097377576 MirTarget -0.325126439143466 0.0223392469049946 NA NA NA hsa-miR-125b-5p PRKAA2 -0.548859243919575 0.0107224406584463 0.538393374272207 0.161947097377576 miRNATAP -0.202662774732203 0.0141995110141762 NA NA NA hsa-miR-146b-5p PRKAA2 1.0922867893808 5.63754607494775e-06 0.538393374272207 0.161947097377576 MirTarget -0.166665248129777 0.0228876121002016 NA NA NA hsa-miR-181a-2-3p PRKAA2 -0.0760679893470186 0.687414621472156 0.538393374272207 0.161947097377576 mirMAP -0.232484812699189 0.0139583148048857 NA NA NA hsa-miR-181a-5p PRKAA2 -0.375429731222937 0.0562142867129802 0.538393374272207 0.161947097377576 mirMAP -0.311080031450075 0.000579878404322497 NA NA NA hsa-miR-181b-5p PRKAA2 0.668793269169928 0.000239998092406404 0.538393374272207 0.161947097377576 mirMAP -0.245629124669417 0.0117937560300616 NA NA NA hsa-miR-195-3p PRKAA2 -1.33068822339418 6.65427393047357e-09 0.538393374272207 0.161947097377576 mirMAP -0.229466349604648 0.00267676408985009 NA NA NA hsa-miR-224-3p PRKAA2 0.921090817288022 0.010010047721564 0.538393374272207 0.161947097377576 mirMAP -0.248496162993324 1.14191896162547e-06 NA NA NA hsa-miR-29b-2-5p PRKAA2 0.345881055247341 0.194842633194187 0.538393374272207 0.161947097377576 mirMAP -0.145301188146975 0.0292975652174133 NA NA NA hsa-miR-3065-5p PRKAA2 0.653308707552535 0.0999497219778851 0.538393374272207 0.161947097377576 mirMAP;miRNATAP -0.195172355521502 5.33128383987359e-05 NA NA NA hsa-miR-30a-3p PRKAA2 -2.54042202792785 2.9111625410859e-18 0.538393374272207 0.161947097377576 MirTarget;miRNATAP -0.236648976996956 4.87801912942201e-05 NA NA NA hsa-miR-30a-5p PRKAA2 -0.924084264430689 0.000762030454634728 0.538393374272207 0.161947097377576 MirTarget -0.237163243849172 0.000217608017414726 NA NA NA hsa-miR-30c-5p PRKAA2 -0.327319105755825 0.123595832152687 0.538393374272207 0.161947097377576 MirTarget -0.197341844705708 0.0186047347361979 NA NA NA hsa-miR-30d-5p PRKAA2 -0.920901858717441 3.50898334321668e-05 0.538393374272207 0.161947097377576 MirTarget -0.180257890196245 0.0232255895212272 NA NA NA hsa-miR-30e-3p PRKAA2 -0.104420043859122 0.526240453209293 0.538393374272207 0.161947097377576 MirTarget -0.432424323338152 6.49846424605619e-05 NA NA NA hsa-miR-338-5p PRKAA2 -1.83316380675941 4.03269924759167e-07 0.538393374272207 0.161947097377576 mirMAP -0.135451315631486 0.00509488170288173 NA NA NA hsa-miR-452-3p PRKAA2 0.477736876273128 0.22218404598603 0.538393374272207 0.161947097377576 mirMAP -0.138574793467526 0.00859738947393167 NA NA NA hsa-miR-338-5p RHEB -1.83316380675941 4.03269924759167e-07 0.556690295005146 5.24242907453425e-05 MirTarget;PITA;miRNATAP -0.106669897326297 4.28378835676612e-10 NA NA NA hsa-let-7i-5p RICTOR 0.605080599172936 1.48406814653206e-06 0.205074646485301 0.167047133309958 MirTarget;miRNATAP -0.216846796952412 6.7442093867109e-05 NA NA NA hsa-miR-140-3p RICTOR -1.11373309124537 8.35257079443689e-14 0.205074646485301 0.167047133309958 MirTarget;PITA;miRNATAP -0.192222426030626 1.70037041973378e-05 NA NA NA hsa-miR-148a-3p RICTOR 2.30885799126944 1.95226081368985e-21 0.205074646485301 0.167047133309958 MirTarget;miRNATAP -0.122511932896008 4.37300198476903e-06 NA NA NA hsa-miR-155-5p RICTOR 0.813513839059142 0.000608282725633232 0.205074646485301 0.167047133309958 miRNAWalker2_validate;miRNATAP -0.111586899549671 9.2517096184809e-05 NA NA NA hsa-miR-16-1-3p RICTOR 1.50034693398929 6.63958242991125e-10 0.205074646485301 0.167047133309958 MirTarget -0.114167738032603 0.000860374966953905 NA NA NA hsa-miR-181a-5p RICTOR -0.375429731222937 0.0562142867129802 0.205074646485301 0.167047133309958 mirMAP -0.111889090715298 0.00130031776908697 NA NA NA hsa-miR-342-3p RICTOR -0.128691966564961 0.561034080130801 0.205074646485301 0.167047133309958 MirTarget;PITA;miRanda;miRNATAP -0.15221390686529 6.89191417357731e-07 NA NA NA hsa-miR-497-5p RICTOR -0.0546347378264729 0.786205564901684 0.205074646485301 0.167047133309958 MirTarget;miRNATAP -0.153615505776871 5.59625316673334e-06 NA NA NA hsa-miR-106b-5p RPS6KA1 1.47447672652218 1.32004094930462e-13 -0.579524551675261 6.59532330551602e-06 miRNATAP -0.170585553839829 3.30400709254468e-09 NA NA NA hsa-miR-17-5p RPS6KA1 2.07078488653279 2.77403038572568e-19 -0.579524551675261 6.59532330551602e-06 TargetScan;miRNATAP -0.127198057927073 2.37610720642865e-07 NA NA NA hsa-miR-28-5p RPS6KA1 1.19639196514745 4.59365801666536e-18 -0.579524551675261 6.59532330551602e-06 miRanda -0.102026942669223 0.0155379575719969 NA NA NA hsa-miR-335-3p RPS6KA1 1.51116383169018 6.88553098788624e-13 -0.579524551675261 6.59532330551602e-06 MirTarget -0.162897661929928 2.431088402922e-09 NA NA NA hsa-miR-421 RPS6KA1 0.170525317701774 0.535277026680289 -0.579524551675261 6.59532330551602e-06 PITA;miRanda -0.128026047772527 3.99920194868673e-08 NA NA NA hsa-miR-93-5p RPS6KA1 1.50844106515467 1.83836866996875e-12 -0.579524551675261 6.59532330551602e-06 miRNATAP -0.116839091711322 1.6238645273994e-05 NA NA NA hsa-let-7g-3p RPS6KA2 2.38336858943031 4.8771148585792e-17 -1.04343331479045 1.62125928478786e-06 MirTarget -0.104782266150183 0.00230430762602138 NA NA NA hsa-miR-130b-5p RPS6KA2 1.53645187062942 1.10498816261505e-08 -1.04343331479045 1.62125928478786e-06 mirMAP -0.218195907469878 2.36792623924417e-09 NA NA NA hsa-miR-17-5p RPS6KA2 2.07078488653279 2.77403038572568e-19 -1.04343331479045 1.62125928478786e-06 TargetScan -0.237976044364187 1.13643203010135e-08 NA NA NA hsa-miR-193a-3p RPS6KA2 0.549173467360291 0.0319030569365466 -1.04343331479045 1.62125928478786e-06 mirMAP -0.236767612468823 2.40694553868879e-08 NA NA NA hsa-miR-193b-3p RPS6KA2 1.10444771306846 0.000822888533401377 -1.04343331479045 1.62125928478786e-06 mirMAP -0.126899545109533 2.89329618031281e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 2.11776595911517 7.07663078397156e-10 -1.04343331479045 1.62125928478786e-06 MirTarget -0.116355097297911 0.00074614825058899 NA NA NA hsa-miR-21-3p RPS6KA2 2.54206008030157 1.11598785398763e-30 -1.04343331479045 1.62125928478786e-06 MirTarget -0.148330264666295 0.000543858038536522 NA NA NA hsa-miR-3127-5p RPS6KA2 0.382717393698386 0.11535780874721 -1.04343331479045 1.62125928478786e-06 mirMAP -0.105090628645049 0.011884977607684 NA NA NA hsa-miR-9-5p RPS6KA2 4.99250901331516 2.59132733422801e-19 -1.04343331479045 1.62125928478786e-06 miRNATAP -0.130728183864576 1.3447378269276e-14 NA NA NA hsa-miR-93-3p RPS6KA2 1.07631808403007 1.63747525692813e-05 -1.04343331479045 1.62125928478786e-06 MirTarget -0.2105417211806 1.25415597157338e-07 NA NA NA hsa-miR-106a-5p RPS6KA3 1.3902608059488 6.07931522284525e-05 -0.054195404659354 0.708624881834648 miRNATAP -0.101192877969631 1.67110384493832e-06 NA NA NA hsa-miR-106b-5p RPS6KA3 1.47447672652218 1.32004094930462e-13 -0.054195404659354 0.708624881834648 miRNATAP -0.143779184370637 9.44910304249055e-06 NA NA NA hsa-miR-140-5p RPS6KA3 0.669142684153918 0.000335928403032308 -0.054195404659354 0.708624881834648 PITA;miRanda;miRNATAP -0.101226805597237 0.00573251834087782 NA NA NA hsa-miR-15a-5p RPS6KA3 1.62575353599172 1.55312121019827e-19 -0.054195404659354 0.708624881834648 MirTarget;miRNATAP -0.118757114096311 0.000871264793923372 NA NA NA hsa-miR-16-2-3p RPS6KA3 0.503964803530872 0.0263648405197492 -0.054195404659354 0.708624881834648 mirMAP -0.172483371225758 4.47653889948318e-08 NA NA NA hsa-miR-16-5p RPS6KA3 0.749619098384047 4.11649450706988e-06 -0.054195404659354 0.708624881834648 miRNAWalker2_validate;MirTarget;miRNATAP -0.165220770211374 4.86739262441925e-05 NA NA NA hsa-miR-17-5p RPS6KA3 2.07078488653279 2.77403038572568e-19 -0.054195404659354 0.708624881834648 TargetScan;miRNATAP -0.173679048296375 1.94712725304908e-10 NA NA NA hsa-miR-186-5p RPS6KA3 0.852175445703945 6.88885738584309e-10 -0.054195404659354 0.708624881834648 MirTarget;mirMAP;miRNATAP -0.176300481853613 0.000226582290752102 NA NA NA hsa-miR-20a-5p RPS6KA3 2.64649625616975 5.1469418982085e-27 -0.054195404659354 0.708624881834648 miRNATAP -0.138269696703583 4.38347399641463e-08 NA NA NA hsa-miR-320b RPS6KA3 0.226640952564488 0.378818692487242 -0.054195404659354 0.708624881834648 miRanda -0.108216454551594 2.67401563925856e-05 NA NA NA hsa-miR-590-3p RPS6KA3 0.83851360565783 0.00129224433453587 -0.054195404659354 0.708624881834648 mirMAP -0.113580912429783 0.000193243638199445 NA NA NA hsa-miR-590-5p RPS6KA3 2.07441240363458 4.95240551694843e-14 -0.054195404659354 0.708624881834648 PITA;mirMAP;miRNATAP -0.185485877537653 1.00317938157498e-10 NA NA NA hsa-miR-7-1-3p RPS6KA3 2.61364240402652 1.98959237815786e-32 -0.054195404659354 0.708624881834648 mirMAP -0.102247713678445 0.000565084636142267 NA NA NA hsa-miR-93-5p RPS6KA3 1.50844106515467 1.83836866996875e-12 -0.054195404659354 0.708624881834648 miRNATAP -0.156371244608171 2.09555576720906e-07 NA NA NA hsa-miR-141-3p RPS6KA6 3.36993755486106 5.42939251147195e-32 -0.310498541708228 0.547641965662978 MirTarget -0.154620306634159 0.0461769482364732 NA NA NA hsa-miR-199a-3p RPS6KA6 1.67715607711377 5.96963028176444e-15 -0.310498541708228 0.547641965662978 MirTarget -0.277912316945002 0.00987095228027099 NA NA NA hsa-miR-199b-3p RPS6KA6 1.67802185853505 6.03525898173555e-15 -0.310498541708228 0.547641965662978 MirTarget -0.277893304567427 0.00982473730357434 NA NA NA hsa-miR-200a-3p RPS6KA6 3.14766878548496 1.32850889777422e-21 -0.310498541708228 0.547641965662978 MirTarget -0.152651290560585 0.0308196303663354 NA NA NA hsa-miR-26b-5p RPS6KA6 0.72362441215247 4.7794659748036e-05 -0.310498541708228 0.547641965662978 miRNAWalker2_validate;MirTarget -0.308951479696915 0.020854632209809 NA NA NA hsa-miR-424-5p RPS6KA6 1.26485330287919 6.1498991028257e-06 -0.310498541708228 0.547641965662978 MirTarget -0.260514614017034 0.00195714760384445 NA NA NA hsa-miR-590-3p RPS6KA6 0.83851360565783 0.00129224433453587 -0.310498541708228 0.547641965662978 MirTarget;miRanda;mirMAP;miRNATAP -0.377977107702572 0.000520704002280122 NA NA NA hsa-miR-708-3p RPS6KA6 3.43841959417743 4.40027692981683e-28 -0.310498541708228 0.547641965662978 MirTarget -0.246540887468603 0.00199652994756385 NA NA NA hsa-miR-96-5p RPS6KA6 3.0381097138467 4.40362891630201e-24 -0.310498541708228 0.547641965662978 MirTarget;TargetScan -0.257070525875399 0.00305783578647258 NA NA NA hsa-miR-139-5p RPS6KB1 -2.26625553116965 7.22375119369519e-16 0.395075168795546 0.000566740506607704 PITA;miRanda -0.110290868714374 7.45237907447142e-10 NA NA NA hsa-miR-145-5p RPS6KB1 -1.34926078156437 2.63526538800669e-07 0.395075168795546 0.000566740506607704 MirTarget;miRNATAP -0.15695919845232 4.51835368672558e-16 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-181a-5p RPS6KB1 -0.375429731222937 0.0562142867129802 0.395075168795546 0.000566740506607704 MirTarget;miRNATAP -0.12611116022247 2.50376013250516e-06 NA NA NA hsa-miR-181c-5p RPS6KB1 0.529875814537156 0.0125885822998008 0.395075168795546 0.000566740506607704 MirTarget;miRNATAP -0.155514169262014 2.18592208444415e-10 NA NA NA hsa-miR-218-5p RPS6KB1 -0.281408491748349 0.259553612322657 0.395075168795546 0.000566740506607704 miRNATAP -0.162598141425799 1.69303431906451e-14 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-30a-5p RPS6KB1 -0.924084264430689 0.000762030454634728 0.395075168795546 0.000566740506607704 mirMAP;miRNATAP -0.148550414041994 1.43728166295243e-15 NA NA NA hsa-miR-30c-5p RPS6KB1 -0.327319105755825 0.123595832152687 0.395075168795546 0.000566740506607704 mirMAP;miRNATAP -0.17709647899443 3.62948426630194e-13 NA NA NA hsa-miR-342-3p RPS6KB1 -0.128691966564961 0.561034080130801 0.395075168795546 0.000566740506607704 miRanda -0.112495506128509 2.24824143704172e-06 NA NA NA hsa-miR-455-5p RPS6KB1 1.36946341828134 5.05118627562807e-08 0.395075168795546 0.000566740506607704 MirTarget;PITA;miRanda -0.124485509450113 1.60253793337003e-07 NA NA NA hsa-miR-664a-3p RPS6KB1 0.443077463053857 0.0214248925850984 0.395075168795546 0.000566740506607704 MirTarget -0.152855467444993 1.90456092065456e-08 NA NA NA hsa-miR-330-3p STK11 -0.716924999893351 0.000796236278616087 -0.155527087747212 0.383462230680077 mirMAP -0.172508913575347 5.88222779025283e-06 NA NA NA hsa-miR-330-5p STK11 0.168520831101569 0.336433937906706 -0.155527087747212 0.383462230680077 miRanda -0.213332537977904 5.28675914606143e-06 NA NA NA hsa-miR-330-5p STRADA 0.168520831101569 0.336433937906706 0.262062768589299 0.00435727705017258 miRanda -0.12339042561674 2.78189677293405e-07 NA NA NA hsa-miR-10a-5p TSC1 0.790595816051606 0.000593731378445468 -0.0968330404675113 0.413738925573725 mirMAP -0.107998315623831 3.80321635664832e-06 NA NA NA hsa-miR-26a-5p ULK1 -0.126411409001078 0.440028840408711 0.616445128058068 4.11216950040876e-05 miRNATAP -0.295199126819406 2.16699649045898e-12 NA NA NA hsa-miR-330-3p ULK1 -0.716924999893351 0.000796236278616087 0.616445128058068 4.11216950040876e-05 mirMAP -0.14389921736118 8.56942621708805e-06 NA NA NA hsa-miR-335-5p ULK1 -0.466533891325811 0.0676987038122831 0.616445128058068 4.11216950040876e-05 miRNAWalker2_validate -0.114941758258457 0.000159937233374432 NA NA NA hsa-let-7i-5p ULK2 0.605080599172936 1.48406814653206e-06 -0.999737965682963 5.22721140540102e-10 MirTarget -0.294511102339821 8.90934373971495e-07 NA NA NA hsa-miR-22-3p ULK2 1.42501909916631 1.72295005910055e-25 -0.999737965682963 5.22721140540102e-10 MirTarget -0.202239117816988 0.000126937160489846 NA NA NA hsa-miR-590-3p ULK2 0.83851360565783 0.00129224433453587 -0.999737965682963 5.22721140540102e-10 mirMAP -0.146619379705561 2.08675678744435e-05 NA NA NA hsa-miR-7-1-3p ULK2 2.61364240402652 1.98959237815786e-32 -0.999737965682963 5.22721140540102e-10 MirTarget;mirMAP -0.130540314961532 9.99435798036426e-05 NA NA NA hsa-miR-1-3p VEGFA -1.48412019995919 0.000242034342580425 0.230749341603949 0.311300638391058 MirTarget -0.172921089301484 3.76698090411866e-10 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA 1.38889039459232 1.96522549511542e-09 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.184546125824104 3.21659312920503e-05 NA NA NA hsa-miR-125a-3p VEGFA -1.04954492275266 2.45974219476832e-06 0.230749341603949 0.311300638391058 miRanda -0.155505773345232 0.000854677712414177 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -2.89609207852024 1.71222048144972e-13 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.104720990536239 5.4001689907379e-05 NA NA NA hsa-miR-140-5p VEGFA 0.669142684153918 0.000335928403032308 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.246162039129829 1.79001025551982e-05 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.702328520623782 0.0215316651134431 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.211938415847961 3.12072029375035e-10 NA NA NA hsa-miR-15b-5p VEGFA -1.25935038177398 1.83460220856901e-12 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.119640608007297 0.0381907284369183 22904162 TaqMan qRT-PCR was used to assess the expression of the selected miRNAs related to angiogenesis miR-15b -16 -17-5p -20a -21 -125a -200b -210 -214* -221 -222 and -424 and VEGF-A and TSP-1 mRNAs were assessed by qRT-PCR using SYBR Green endometrial cancer hsa-miR-195-5p VEGFA -1.01577502605386 4.80814718341729e-05 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget -0.216253591570711 7.05557590450539e-07 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-29c-3p VEGFA 1.32354490728858 1.84279305179762e-07 0.230749341603949 0.311300638391058 miRNAWalker2_validate;MirTarget -0.189793475587463 2.81724907347383e-06 NA NA NA hsa-miR-330-3p VEGFA -0.716924999893351 0.000796236278616087 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.385541553437526 4.9599607016426e-16 NA NA NA hsa-miR-335-5p VEGFA -0.466533891325811 0.0676987038122831 0.230749341603949 0.311300638391058 miRNAWalker2_validate -0.139733266743143 0.00237085343344445 NA NA NA hsa-miR-361-5p VEGFA 0.21454431962475 0.0800957579368424 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.311546652005902 0.000341919545726308 NA NA NA hsa-miR-374a-3p VEGFA 1.73882813668241 1.57901646296214e-13 0.230749341603949 0.311300638391058 MirTarget -0.116308302225143 0.0073756212717737 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374a-5p VEGFA -0.197027254874826 0.298080902192861 0.230749341603949 0.311300638391058 MirTarget -0.195164100931073 0.0017653451750918 23679262 Our data demonstrated miR-374a to be differentially distributed in breast cancer; VEGF-A and VCAM-1 mRNA had coincident distribution and the distribution of teh respective proteins was uneven and opposite to that for the miR-374a breast cancer hsa-miR-374b-5p VEGFA 0.474691035780475 0.0109217471394203 0.230749341603949 0.311300638391058 MirTarget -0.165654325982956 0.00541935782229369 NA NA NA hsa-miR-378a-3p VEGFA -2.0140903990983 1.146745431034e-18 0.230749341603949 0.311300638391058 miRNAWalker2_validate;miRTarBase -0.188122556602091 1.9053920640873e-05 NA NA NA hsa-miR-27b-3p VEGFC 0.236438984240408 0.12263510345883 -0.994908041109909 0.000325237653433729 MirTarget -0.206770545439801 0.0146895947025967 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer