miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ABI3BP 0.503048155002889 0.0411145454335299 -3.77611646199712 1.93924088044192e-07 miRNATAP -0.823663773579023 0.00014735947661796 NA NA NA hsa-let-7b-3p ABI3BP 0.21838629112113 0.296038413622566 -3.77611646199712 1.93924088044192e-07 miRNATAP -0.950450449723977 0.000244757766963312 NA NA NA hsa-miR-107 ABI3BP 0.904627575346218 4.67936495073904e-05 -3.77611646199712 1.93924088044192e-07 miRanda -1.37386596575889 2.95913697290512e-09 NA NA NA hsa-miR-181a-5p ABI3BP 1.39227281909646 1.91689469974826e-09 -3.77611646199712 1.93924088044192e-07 miRNATAP -0.650319330232783 0.00360945730070807 NA NA NA hsa-miR-181b-5p ABI3BP 1.64216500592669 1.89228845300725e-08 -3.77611646199712 1.93924088044192e-07 miRNATAP -0.656333515283214 0.000188243806581917 NA NA NA hsa-miR-32-3p ABI3BP 0.583525764322974 0.11837203008551 -3.77611646199712 1.93924088044192e-07 mirMAP -0.708606167654753 7.8170180913934e-06 NA NA NA hsa-miR-320a ABI3BP 0.593888711838028 0.011897419390526 -3.77611646199712 1.93924088044192e-07 miRanda -0.777622942890372 0.000609960931387544 NA NA NA hsa-miR-320b ABI3BP 1.11183660885284 0.000497971211648503 -3.77611646199712 1.93924088044192e-07 miRanda -0.863596102748587 8.78514581568791e-08 NA NA NA hsa-miR-320c ABI3BP 0.455072851945474 0.240613785444485 -3.77611646199712 1.93924088044192e-07 miRanda -0.532195072378847 0.000824112006136491 NA NA NA hsa-miR-330-3p ABI3BP 0.798460296022179 0.00746538156533435 -3.77611646199712 1.93924088044192e-07 PITA -0.741257126818898 2.68702112587785e-05 NA NA NA hsa-miR-3662 ABI3BP 1.82780708047676 0.0054036501346178 -3.77611646199712 1.93924088044192e-07 mirMAP;miRNATAP -0.442353231968883 1.66824027009874e-05 NA NA NA hsa-miR-421 ABI3BP 1.80720854070385 1.59709651202848e-07 -3.77611646199712 1.93924088044192e-07 miRanda -0.800648438649626 4.24758124938775e-08 NA NA NA hsa-miR-455-5p ABI3BP 1.20462751989145 6.74386011867484e-05 -3.77611646199712 1.93924088044192e-07 miRanda -0.993278451161882 3.84763545187832e-09 NA NA NA hsa-miR-505-5p ABI3BP 0.406607501325555 0.184328592339472 -3.77611646199712 1.93924088044192e-07 miRNATAP -0.51651473348667 0.00318356449417279 NA NA NA hsa-miR-576-5p ABI3BP 0.625714137488957 0.0417100301848969 -3.77611646199712 1.93924088044192e-07 PITA -0.967484070434148 9.80705739426327e-09 NA NA NA hsa-miR-590-3p ABI3BP 1.11654983899947 0.000160782154924864 -3.77611646199712 1.93924088044192e-07 miRanda -0.96974774185556 2.27408305207468e-08 NA NA NA hsa-miR-590-5p ABI3BP 1.04171442093217 0.000272475544954865 -3.77611646199712 1.93924088044192e-07 miRanda -1.38680347508306 8.77453313547531e-16 NA NA NA hsa-miR-92a-3p ABI3BP 1.2209325870225 6.8757197708107e-06 -3.77611646199712 1.93924088044192e-07 miRNATAP -1.42832575840546 2.94399554365574e-15 NA NA NA hsa-miR-92b-3p ABI3BP 1.33518446513417 1.45350885391576e-06 -3.77611646199712 1.93924088044192e-07 miRNATAP -1.01383886198666 3.35103964181152e-08 NA NA NA hsa-miR-484 ACTA2 0.71327898984355 0.00233605130771196 -1.81681926984773 5.56541615090772e-05 miRNAWalker2_validate -0.735921158739604 6.92551057563795e-08 NA NA NA hsa-miR-139-5p ADAM12 -1.83374360776637 1.22019901002824e-09 3.78560012660482 1.76838163048936e-10 miRanda -0.943945623315229 2.09055982196208e-12 NA NA NA hsa-miR-26a-5p ADAM12 -0.384110714440647 0.0442498636014044 3.78560012660482 1.76838163048936e-10 mirMAP;miRNATAP -0.858504567069708 0.000281144076792846 NA NA NA hsa-miR-26b-5p ADAM12 -0.301646326928219 0.160081421968103 3.78560012660482 1.76838163048936e-10 mirMAP;miRNATAP -0.571732444959782 0.00669843228308486 NA NA NA hsa-miR-29a-3p ADAM12 -0.113012156986374 0.615005009685815 3.78560012660482 1.76838163048936e-10 miRNATAP -0.895167875800412 6.247000098562e-06 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29b-3p ADAM12 -0.230693226193598 0.367461626035234 3.78560012660482 1.76838163048936e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.618656200020456 0.00039492615879481 25886595 ADAM12 L is a direct target of the miR 29 and miR 200 families in breast cancer breast cancer hsa-miR-29c-3p ADAM12 -1.62454036584589 5.38376515586029e-07 3.78560012660482 1.76838163048936e-10 miRNATAP -0.758954902618596 4.09531718842743e-09 NA NA NA hsa-miR-338-3p ADAM12 -0.959276231066179 0.0191473351014091 3.78560012660482 1.76838163048936e-10 miRanda -0.66483848615809 1.29914612180089e-10 NA NA NA hsa-miR-1271-5p ANPEP 1.15538250415776 0.00207865862606828 2.60039344921599 0.00055432124609517 mirMAP -0.442291316968587 0.0023443700899972 NA NA NA hsa-miR-24-3p ANPEP 1.08578167539644 6.18549359075268e-07 2.60039344921599 0.00055432124609517 miRNAWalker2_validate -0.690812524258126 0.00510037746035531 NA NA NA hsa-miR-129-5p AREG -2.56914016541176 2.36237896095709e-06 0.455946668090932 0.445206623022083 miRanda -0.383851729645084 3.64828245349376e-07 NA NA NA hsa-miR-107 BASP1 0.904627575346218 4.67936495073904e-05 0.833872447927385 0.118805385414859 miRanda -0.726617272723948 1.6748151277482e-05 NA NA NA hsa-miR-200b-3p BASP1 0.974577911407732 0.0595020056914543 0.833872447927385 0.118805385414859 TargetScan -0.396440220720014 2.58351833153644e-08 NA NA NA hsa-miR-200c-3p BASP1 1.28185685499076 0.00369777635539177 0.833872447927385 0.118805385414859 miRNATAP -0.289150352708109 0.000679003605613084 NA NA NA hsa-miR-33a-3p BASP1 0.347011402017138 0.321709379745392 0.833872447927385 0.118805385414859 miRNATAP -0.307007290642515 0.00764888399733397 NA NA NA hsa-miR-429 BASP1 1.40182602301928 0.00900426780286475 0.833872447927385 0.118805385414859 PITA;miRanda;miRNATAP -0.336324950356768 1.06599294007027e-06 NA NA NA hsa-miR-532-3p BASP1 0.552364451472481 0.0975490365586023 0.833872447927385 0.118805385414859 PITA -0.615591638846623 3.20419749279537e-08 NA NA NA hsa-miR-7-5p BASP1 1.63575693499363 0.0124424214624534 0.833872447927385 0.118805385414859 miRNATAP -0.332778517357766 1.38468611424248e-08 NA NA NA hsa-miR-192-3p BDNF 0.355565421687399 0.74117031340037 0.736006518564608 0.183812338919891 MirTarget;miRNATAP -0.106082522009255 0.00423859909260241 NA NA NA hsa-miR-29b-2-5p BDNF -1.7015307882027 2.84239251703401e-10 0.736006518564608 0.183812338919891 mirMAP -0.375479531938686 0.00761861774409137 NA NA NA hsa-miR-338-5p BDNF -1.19659203838734 0.0100316010080496 0.736006518564608 0.183812338919891 miRNATAP -0.30035007324931 0.000332002329074772 NA NA NA hsa-miR-30b-3p BGN -0.266398938200332 0.400847813143994 2.03548879034405 3.42640545285261e-06 mirMAP -0.528531032912889 9.11997715085566e-08 NA NA NA hsa-miR-486-5p BGN -0.627607241830911 0.155274583521138 2.03548879034405 3.42640545285261e-06 miRanda -0.249531300078601 0.000529002863454361 NA NA NA hsa-miR-139-3p BMP1 -1.07670920846813 0.00142404330509873 1.36413073786402 1.24454654422178e-06 miRNATAP -0.286995631331775 1.26662957187293e-06 NA NA NA hsa-miR-139-5p BMP1 -1.83374360776637 1.22019901002824e-09 1.36413073786402 1.24454654422178e-06 miRanda -0.340557159901946 9.45426168060165e-08 NA NA NA hsa-miR-29a-3p BMP1 -0.113012156986374 0.615005009685815 1.36413073786402 1.24454654422178e-06 miRNATAP -0.241799372767322 0.00957373981578096 NA NA NA hsa-miR-29b-3p BMP1 -0.230693226193598 0.367461626035234 1.36413073786402 1.24454654422178e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.348878058961628 1.34164043566011e-05 NA NA NA hsa-miR-29c-3p BMP1 -1.62454036584589 5.38376515586029e-07 1.36413073786402 1.24454654422178e-06 miRNATAP -0.325388988617687 6.26710533914739e-08 NA NA NA hsa-miR-30b-3p BMP1 -0.266398938200332 0.400847813143994 1.36413073786402 1.24454654422178e-06 miRNATAP -0.257298308712862 6.70351149628542e-05 NA NA NA hsa-miR-335-5p BMP1 1.59953351087307 5.56170899867314e-05 1.36413073786402 1.24454654422178e-06 miRNAWalker2_validate -0.20207399350688 5.94326108821306e-05 NA NA NA hsa-miR-362-5p BMP1 -0.354508685915981 0.354912078595613 1.36413073786402 1.24454654422178e-06 mirMAP -0.306324382841684 3.67442126634366e-09 NA NA NA hsa-miR-429 BMP1 1.40182602301928 0.00900426780286475 1.36413073786402 1.24454654422178e-06 miRNATAP -0.112497947748111 0.00298696247369672 NA NA NA hsa-miR-141-3p CADM1 1.45548825076434 0.00115958850961764 -1.20797909023227 0.0235651410767351 MirTarget;TargetScan -0.232529754167202 0.00573723297266833 NA NA NA hsa-miR-27a-3p CADM1 1.29886998470345 2.68986118553486e-08 -1.20797909023227 0.0235651410767351 MirTarget;miRNATAP -0.450971658232261 0.00473251535345281 NA NA NA hsa-miR-31-3p CADM1 0.474904754927656 0.506866261575484 -1.20797909023227 0.0235651410767351 MirTarget;miRNATAP -0.148343956571227 0.0056785189593363 NA NA NA hsa-let-7g-5p CALD1 0.325297685027927 0.241142963826631 -1.32900388316017 0.000860925336823146 miRNATAP -0.301655591144497 0.00385095323986056 NA NA NA hsa-miR-106a-5p CALD1 -0.173255688252641 0.642872703263671 -1.32900388316017 0.000860925336823146 miRNATAP -0.241651722713727 0.00168750942976741 NA NA NA hsa-miR-106b-5p CALD1 1.70863907461894 2.04074794107142e-08 -1.32900388316017 0.000860925336823146 miRNATAP -0.668092431277837 5.02220837797705e-15 NA NA NA hsa-miR-107 CALD1 0.904627575346218 4.67936495073904e-05 -1.32900388316017 0.000860925336823146 miRanda -0.869891168832604 1.08138317615077e-12 NA NA NA hsa-miR-10b-3p CALD1 0.773619331000039 0.0076628900286607 -1.32900388316017 0.000860925336823146 miRNATAP -0.313860522037344 0.00148125434671595 NA NA NA hsa-miR-126-5p CALD1 0.41765430251855 0.0753161203651532 -1.32900388316017 0.000860925336823146 mirMAP -0.587854709316706 1.29987077334921e-06 NA NA NA hsa-miR-142-3p CALD1 1.32364054836498 0.0001537753622128 -1.32900388316017 0.000860925336823146 miRanda -0.341097858635533 2.00121038562096e-05 NA NA NA hsa-miR-142-5p CALD1 1.55592486377018 6.69269968016779e-06 -1.32900388316017 0.000860925336823146 PITA;mirMAP -0.372142163260435 3.29922897168437e-06 NA NA NA hsa-miR-15a-5p CALD1 1.03783090449383 7.40334108980898e-07 -1.32900388316017 0.000860925336823146 miRNAWalker2_validate -0.705735104086496 9.31567248127534e-08 NA NA NA hsa-miR-16-2-3p CALD1 1.8048179609245 2.83095715136409e-09 -1.32900388316017 0.000860925336823146 mirMAP -0.667161808945242 4.8310983475306e-15 NA NA NA hsa-miR-17-5p CALD1 1.65862087862483 8.45603406215941e-08 -1.32900388316017 0.000860925336823146 TargetScan;miRNATAP -0.526714546877197 1.33039884272688e-09 NA NA NA hsa-miR-182-5p CALD1 0.887369486030646 0.0310640781418789 -1.32900388316017 0.000860925336823146 MirTarget -0.320221006305906 2.75109483714651e-06 NA NA NA hsa-miR-196a-5p CALD1 6.59255881689547 1.53691144193899e-22 -1.32900388316017 0.000860925336823146 MirTarget -0.254759373697142 1.12954975045954e-12 NA NA NA hsa-miR-196b-5p CALD1 5.58954708296963 1.12099152907987e-19 -1.32900388316017 0.000860925336823146 MirTarget -0.296938289449264 6.38671901790064e-14 NA NA NA hsa-miR-197-3p CALD1 0.888854270009261 0.000195183808214449 -1.32900388316017 0.000860925336823146 MirTarget -0.644664050300413 3.34837526611743e-08 NA NA NA hsa-miR-20a-5p CALD1 1.4503375861709 5.7813456424762e-07 -1.32900388316017 0.000860925336823146 miRNATAP -0.540860141104898 7.7646406840441e-09 NA NA NA hsa-miR-23b-5p CALD1 0.608950043767916 0.0486466728330363 -1.32900388316017 0.000860925336823146 miRNATAP -0.393065976788311 3.54883975222584e-05 NA NA NA hsa-miR-3065-5p CALD1 -0.241623656423063 0.633116553078159 -1.32900388316017 0.000860925336823146 mirMAP -0.240808915992254 2.76280573969844e-05 NA NA NA hsa-miR-32-3p CALD1 0.583525764322974 0.11837203008551 -1.32900388316017 0.000860925336823146 MirTarget -0.546759145287106 3.97091546522651e-11 NA NA NA hsa-miR-320a CALD1 0.593888711838028 0.011897419390526 -1.32900388316017 0.000860925336823146 PITA;miRanda;miRNATAP -0.417755197483142 0.000621945482093088 NA NA NA hsa-miR-320b CALD1 1.11183660885284 0.000497971211648503 -1.32900388316017 0.000860925336823146 PITA;miRanda;miRNATAP -0.445398168430693 3.17874786465166e-07 NA NA NA hsa-miR-320c CALD1 0.455072851945474 0.240613785444485 -1.32900388316017 0.000860925336823146 PITA;miRanda;miRNATAP -0.367300008611426 1.47620176555823e-05 NA NA NA hsa-miR-338-3p CALD1 -0.959276231066179 0.0191473351014091 -1.32900388316017 0.000860925336823146 miRanda -0.244795862780776 0.000420936006080892 NA NA NA hsa-miR-338-5p CALD1 -1.19659203838734 0.0100316010080496 -1.32900388316017 0.000860925336823146 PITA;miRNATAP -0.191741309022126 0.0017246929861749 NA NA NA hsa-miR-34a-5p CALD1 0.794251341270032 0.00024017386701179 -1.32900388316017 0.000860925336823146 miRNAWalker2_validate -0.596124300255101 5.41463766571346e-06 NA NA NA hsa-miR-361-5p CALD1 0.407725414130987 0.0181260969156347 -1.32900388316017 0.000860925336823146 miRanda;miRNATAP -0.514737352493276 0.002621282082217 NA NA NA hsa-miR-3682-3p CALD1 1.96838261925327 4.94885331227292e-06 -1.32900388316017 0.000860925336823146 mirMAP -0.463069911172818 4.83484226527172e-10 NA NA NA hsa-miR-421 CALD1 1.80720854070385 1.59709651202848e-07 -1.32900388316017 0.000860925336823146 miRanda -0.237850846804068 0.00323508950389407 NA NA NA hsa-miR-429 CALD1 1.40182602301928 0.00900426780286475 -1.32900388316017 0.000860925336823146 miRanda -0.464228643541885 1.72418146937749e-22 NA NA NA hsa-miR-484 CALD1 0.71327898984355 0.00233605130771196 -1.32900388316017 0.000860925336823146 PITA -0.461081940517727 0.000160841158486301 NA NA NA hsa-miR-501-3p CALD1 0.731876211669996 0.0270421347018303 -1.32900388316017 0.000860925336823146 TargetScan;miRNATAP -0.492537068874135 4.27939358140955e-09 NA NA NA hsa-miR-590-3p CALD1 1.11654983899947 0.000160782154924864 -1.32900388316017 0.000860925336823146 miRanda;mirMAP -0.564912601945424 1.07651812145734e-09 NA NA NA hsa-miR-590-5p CALD1 1.04171442093217 0.000272475544954865 -1.32900388316017 0.000860925336823146 miRanda -0.608367656728333 1.96486634133853e-10 NA NA NA hsa-miR-93-5p CALD1 1.7515174434778 1.59386482413883e-08 -1.32900388316017 0.000860925336823146 miRNATAP -0.456415794958954 1.80473610248095e-07 NA NA NA hsa-miR-107 CALU 0.904627575346218 4.67936495073904e-05 0.280100163653879 0.175756870564383 MirTarget;PITA;miRanda -0.174974382754896 0.0078801962261502 NA NA NA hsa-miR-126-5p CALU 0.41765430251855 0.0753161203651532 0.280100163653879 0.175756870564383 MirTarget -0.179962884434435 0.00438810866125175 NA NA NA hsa-miR-141-3p CALU 1.45548825076434 0.00115958850961764 0.280100163653879 0.175756870564383 TargetScan -0.134849056398082 2.34606036652022e-05 NA NA NA hsa-miR-150-5p CALU 0.147461377429675 0.753719621305461 0.280100163653879 0.175756870564383 MirTarget -0.168631301641495 2.54956997010619e-08 NA NA NA hsa-miR-16-5p CALU 1.00515772948091 5.33912942007619e-06 0.280100163653879 0.175756870564383 miRNAWalker2_validate;MirTarget -0.182221781396065 0.00566228447776547 NA NA NA hsa-miR-200b-3p CALU 0.974577911407732 0.0595020056914543 0.280100163653879 0.175756870564383 MirTarget;TargetScan -0.125583381337646 5.96597378873911e-06 NA NA NA hsa-miR-200c-3p CALU 1.28185685499076 0.00369777635539177 0.280100163653879 0.175756870564383 MirTarget -0.163674806241524 3.44875234953876e-07 NA NA NA hsa-miR-29c-3p CALU -1.62454036584589 5.38376515586029e-07 0.280100163653879 0.175756870564383 MirTarget -0.218807066592285 3.73435208773888e-07 NA NA NA hsa-miR-30b-5p CALU -0.430720743745757 0.0593564057320791 0.280100163653879 0.175756870564383 MirTarget -0.274438864050682 1.88103957017608e-05 NA NA NA hsa-miR-30d-3p CALU -0.545113326540761 0.0433733076874155 0.280100163653879 0.175756870564383 MirTarget -0.183932751683497 0.000719279693378937 NA NA NA hsa-miR-30d-5p CALU -0.5492586056147 0.0140125082460125 0.280100163653879 0.175756870564383 MirTarget -0.287711680851798 1.05400083752903e-05 NA NA NA hsa-miR-33a-3p CALU 0.347011402017138 0.321709379745392 0.280100163653879 0.175756870564383 mirMAP -0.149178994657899 0.000696796010174229 NA NA NA hsa-miR-429 CALU 1.40182602301928 0.00900426780286475 0.280100163653879 0.175756870564383 MirTarget;PITA;miRanda -0.117616516786071 1.01178730086814e-05 NA NA NA hsa-miR-107 CAP2 0.904627575346218 4.67936495073904e-05 -0.183703886100352 0.646691208478404 miRanda -0.492165080937556 0.000101823578065214 NA NA NA hsa-miR-320b CAP2 1.11183660885284 0.000497971211648503 -0.183703886100352 0.646691208478404 miRanda -0.261968281051043 0.00299971263510872 NA NA NA hsa-miR-335-3p CAP2 2.5197689063267 2.20084506976733e-09 -0.183703886100352 0.646691208478404 mirMAP -0.20680712494999 0.00135026688412814 NA NA NA hsa-miR-429 CAP2 1.40182602301928 0.00900426780286475 -0.183703886100352 0.646691208478404 miRanda -0.384187502264673 5.34659593769934e-15 NA NA NA hsa-miR-582-5p CAP2 -0.448820171762719 0.134615974001015 -0.183703886100352 0.646691208478404 PITA;miRNATAP -0.346957115200773 0.000250484328434156 NA NA NA hsa-miR-590-3p CAP2 1.11654983899947 0.000160782154924864 -0.183703886100352 0.646691208478404 PITA;miRanda;mirMAP -0.359361355123126 0.000143073139185264 NA NA NA hsa-miR-628-5p CAP2 -0.535322919688788 0.0377881249470294 -0.183703886100352 0.646691208478404 miRNATAP -0.343530862578387 0.00198026176584453 NA NA NA hsa-miR-139-5p CAPG -1.83374360776637 1.22019901002824e-09 1.20893078838194 1.43829496945366e-05 miRanda -0.169771394067432 0.00857198472357762 NA NA NA hsa-miR-10a-3p CD44 0.221754213874695 0.560576719784617 1.31414180917739 0.000564804208764868 mirMAP -0.355495864123918 9.94084331809922e-07 NA NA NA hsa-miR-148a-5p CD44 -0.69329616490858 0.0793012233740369 1.31414180917739 0.000564804208764868 mirMAP -0.338489285495325 6.37425234560381e-07 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity liver cancer hsa-miR-30a-3p CD44 -1.73205137750899 3.2425754511091e-07 1.31414180917739 0.000564804208764868 mirMAP -0.250145450691459 0.00145890584436219 NA NA NA hsa-miR-30a-5p CD44 -1.71922855140016 3.20574349285256e-07 1.31414180917739 0.000564804208764868 miRNAWalker2_validate -0.328801058282606 2.78932902282788e-05 NA NA NA hsa-miR-30c-2-3p CD44 -1.13954984520886 0.000846438233267901 1.31414180917739 0.000564804208764868 MirTarget -0.239553943589749 0.00262694153672366 NA NA NA hsa-miR-30e-3p CD44 -0.913131357083321 7.29096855615228e-06 1.31414180917739 0.000564804208764868 mirMAP -0.432044778177797 0.00128542720513351 NA NA NA hsa-miR-326 CD44 -0.429748586406214 0.2629894124021 1.31414180917739 0.000564804208764868 miRanda -0.379134263813038 7.73270343691305e-08 NA NA NA hsa-miR-532-3p CD44 0.552364451472481 0.0975490365586023 1.31414180917739 0.000564804208764868 miRNATAP -0.442374334235447 3.57038282762698e-08 NA NA NA hsa-miR-577 CD44 0.911619788986754 0.2256062124148 1.31414180917739 0.000564804208764868 MirTarget;PITA;miRNATAP -0.233585578672161 5.63910186599433e-11 NA NA NA hsa-let-7d-5p CD59 0.981733854788227 7.26366577706469e-07 -0.921769901427892 0.000170784649233384 MirTarget -0.30944981654357 0.000445582915359733 NA NA NA hsa-let-7e-5p CD59 0.405855894534493 0.196257828016759 -0.921769901427892 0.000170784649233384 MirTarget -0.17564401056266 0.00186206036595087 NA NA NA hsa-let-7f-5p CD59 0.634633924115866 0.0344982923411787 -0.921769901427892 0.000170784649233384 MirTarget -0.208679388286112 0.000377297850182286 NA NA NA hsa-let-7g-5p CD59 0.325297685027927 0.241142963826631 -0.921769901427892 0.000170784649233384 MirTarget -0.240576745135101 0.000160877476813221 NA NA NA hsa-miR-141-3p CD59 1.45548825076434 0.00115958850961764 -0.921769901427892 0.000170784649233384 mirMAP -0.142353516887761 0.000234262748630582 NA NA NA hsa-miR-200a-3p CD59 0.717826667295984 0.193912116506827 -0.921769901427892 0.000170784649233384 mirMAP -0.105144892287585 0.000935381458823298 NA NA NA hsa-miR-335-3p CD59 2.5197689063267 2.20084506976733e-09 -0.921769901427892 0.000170784649233384 mirMAP -0.211387895567148 6.50442698161817e-08 NA NA NA hsa-miR-92a-3p CD59 1.2209325870225 6.8757197708107e-06 -0.921769901427892 0.000170784649233384 miRNAWalker2_validate -0.361728442055139 5.61954186650356e-09 NA NA NA hsa-miR-98-5p CD59 0.919961309193122 2.61963790596372e-05 -0.921769901427892 0.000170784649233384 MirTarget -0.341672900290708 1.71153576490354e-05 NA NA NA hsa-miR-126-5p CDH11 0.41765430251855 0.0753161203651532 0.76293386461244 0.103078604608995 mirMAP -0.646950340118322 4.8559493628113e-06 NA NA NA hsa-miR-139-5p CDH11 -1.83374360776637 1.22019901002824e-09 0.76293386461244 0.103078604608995 miRanda -0.463548495108669 9.69443487239359e-06 NA NA NA hsa-miR-200b-3p CDH11 0.974577911407732 0.0595020056914543 0.76293386461244 0.103078604608995 TargetScan -0.275005613096762 1.39817837232751e-05 NA NA NA hsa-miR-32-3p CDH11 0.583525764322974 0.11837203008551 0.76293386461244 0.103078604608995 mirMAP -0.346665322989353 0.000532519047487587 NA NA NA hsa-miR-335-5p CDH11 1.59953351087307 5.56170899867314e-05 0.76293386461244 0.103078604608995 miRNAWalker2_validate -0.283477463729736 0.00055955150528369 NA NA NA hsa-miR-362-3p CDH11 -0.0349414695893027 0.913780708043777 0.76293386461244 0.103078604608995 miRanda -0.382737917853934 0.000220209018136196 NA NA NA hsa-miR-429 CDH11 1.40182602301928 0.00900426780286475 0.76293386461244 0.103078604608995 PITA;miRanda -0.265666590592953 1.20709298523616e-05 NA NA NA hsa-miR-500a-5p CDH11 0.00337014556047865 0.992120109131868 0.76293386461244 0.103078604608995 mirMAP -0.326927312104223 0.000839432206988911 NA NA NA hsa-miR-577 CDH11 0.911619788986754 0.2256062124148 0.76293386461244 0.103078604608995 mirMAP -0.186812460697027 2.93091379094646e-05 NA NA NA hsa-miR-7-1-3p CDH11 0.709309110750947 0.0412301737463194 0.76293386461244 0.103078604608995 mirMAP -0.29930654246312 0.00177388641033165 NA NA NA hsa-miR-194-5p CDH2 -0.127742909829168 0.906065815804667 -3.91852900886169 4.90260379144859e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309475435628537 1.04681844700995e-09 21845495;20979124 The results of real-time PCR and western blot highlighted that miR-194 interacted with N-cadherin and negatively regulated its expression at the translational level;The overexpression of miR-194 in liver mesenchymal-like cancer cells reduced the expression of the mesenchymal cell marker N-cadherin and suppressed invasion and migration of the mesenchymal-like cancer cells both in vitro and in vivo ; gastric cancer;liver cancer hsa-miR-27b-5p CDH2 0.680479953627235 0.0149700717026754 -3.91852900886169 4.90260379144859e-07 miRNAWalker2_validate -0.61710394051541 0.00258584038898974 NA NA NA hsa-miR-320a CDH2 0.593888711838028 0.011897419390526 -3.91852900886169 4.90260379144859e-07 MirTarget;PITA;miRanda;miRNATAP -0.63085912069411 0.00994132609101179 NA NA NA hsa-miR-320b CDH2 1.11183660885284 0.000497971211648503 -3.91852900886169 4.90260379144859e-07 MirTarget;PITA;miRanda;miRNATAP -0.607016348466033 0.000592105998447137 NA NA NA hsa-miR-320c CDH2 0.455072851945474 0.240613785444485 -3.91852900886169 4.90260379144859e-07 MirTarget;PITA;miRanda;miRNATAP -0.452514631475795 0.00829727348231295 NA NA NA hsa-miR-429 CDH2 1.40182602301928 0.00900426780286475 -3.91852900886169 4.90260379144859e-07 miRanda -0.626266206037418 7.1779629438742e-10 NA NA NA hsa-miR-532-3p CDH2 0.552364451472481 0.0975490365586023 -3.91852900886169 4.90260379144859e-07 PITA -0.89120232400242 1.04886045110055e-07 NA NA NA hsa-miR-615-3p CDH2 2.82967143704683 3.05118423223543e-05 -3.91852900886169 4.90260379144859e-07 miRNAWalker2_validate -0.391991463876457 0.000584304445235138 NA NA NA hsa-miR-624-5p CDH2 1.03467956701702 0.0010908013402586 -3.91852900886169 4.90260379144859e-07 MirTarget -0.612650480858775 0.0012056656352473 NA NA NA hsa-miR-7-1-3p CDH2 0.709309110750947 0.0412301737463194 -3.91852900886169 4.90260379144859e-07 mirMAP -0.739926254110562 4.84256528748948e-06 NA NA NA hsa-miR-452-5p CDH6 2.08756506185889 0.000258095769002813 0.468266305220966 0.260517570663199 mirMAP -0.146687021965452 0.00392922126594849 NA NA NA hsa-miR-944 CDH6 3.33123095809751 0.0177835044930391 0.468266305220966 0.260517570663199 PITA;miRNATAP -0.1043368121069 2.05120375713814e-05 NA NA NA hsa-miR-126-5p COL11A1 0.41765430251855 0.0753161203651532 5.53946782596122 3.04522843164592e-06 MirTarget;mirMAP -2.36448365925725 3.83841295982747e-11 NA NA NA hsa-miR-139-5p COL11A1 -1.83374360776637 1.22019901002824e-09 5.53946782596122 3.04522843164592e-06 miRanda -2.25375053435201 5.24363062812138e-19 NA NA NA hsa-miR-26a-5p COL11A1 -0.384110714440647 0.0442498636014044 5.53946782596122 3.04522843164592e-06 miRNATAP -1.7267280873492 0.000182850747834044 NA NA NA hsa-miR-26b-5p COL11A1 -0.301646326928219 0.160081421968103 5.53946782596122 3.04522843164592e-06 miRNATAP -1.40024713560824 0.00063385755304572 NA NA NA hsa-miR-29a-3p COL11A1 -0.113012156986374 0.615005009685815 5.53946782596122 3.04522843164592e-06 MirTarget;miRNATAP -1.99333743481043 2.10038701225101e-07 NA NA NA hsa-miR-29b-3p COL11A1 -0.230693226193598 0.367461626035234 5.53946782596122 3.04522843164592e-06 MirTarget;miRNATAP -1.47093753960579 1.38802323316411e-05 NA NA NA hsa-miR-29c-3p COL11A1 -1.62454036584589 5.38376515586029e-07 5.53946782596122 3.04522843164592e-06 MirTarget;miRNATAP -1.6358646824572 5.62542125891041e-11 NA NA NA hsa-miR-32-5p COL11A1 0.415247682945382 0.106458022460373 5.53946782596122 3.04522843164592e-06 MirTarget -1.02065660236616 0.00270357844585568 NA NA NA hsa-miR-335-5p COL11A1 1.59953351087307 5.56170899867314e-05 5.53946782596122 3.04522843164592e-06 miRNAWalker2_validate -0.784369815210939 0.000234934201565645 NA NA NA hsa-miR-362-3p COL11A1 -0.0349414695893027 0.913780708043777 5.53946782596122 3.04522843164592e-06 miRanda -1.1550783859535 1.60330035097498e-05 NA NA NA hsa-miR-664a-3p COL11A1 -0.83041219170254 0.000136267547251167 5.53946782596122 3.04522843164592e-06 mirMAP -1.09302553149169 0.00621477148204409 NA NA NA hsa-miR-7-1-3p COL11A1 0.709309110750947 0.0412301737463194 5.53946782596122 3.04522843164592e-06 mirMAP -0.89503895916344 0.000307965882965954 NA NA NA hsa-miR-107 COL12A1 0.904627575346218 4.67936495073904e-05 1.25452333786146 0.00320715866236616 miRanda -0.568596342742752 2.74261092011164e-05 NA NA NA hsa-miR-126-5p COL12A1 0.41765430251855 0.0753161203651532 1.25452333786146 0.00320715866236616 mirMAP -0.642524843884952 6.39397084027779e-07 NA NA NA hsa-miR-16-5p COL12A1 1.00515772948091 5.33912942007619e-06 1.25452333786146 0.00320715866236616 MirTarget;miRNATAP -0.553041775814114 4.70285478391764e-05 NA NA NA hsa-miR-17-3p COL12A1 1.31126744284937 3.24768335024185e-07 1.25452333786146 0.00320715866236616 MirTarget;miRNATAP -0.403895359991313 0.000501542219822538 NA NA NA hsa-miR-195-5p COL12A1 -0.907998841926297 0.00150511564650591 1.25452333786146 0.00320715866236616 MirTarget;miRNATAP -0.369071263162839 0.000493904394719917 NA NA NA hsa-miR-222-5p COL12A1 1.87968474330782 1.11743009485711e-06 1.25452333786146 0.00320715866236616 MirTarget -0.22639452176381 0.0032896279045514 NA NA NA hsa-miR-26a-5p COL12A1 -0.384110714440647 0.0442498636014044 1.25452333786146 0.00320715866236616 miRNATAP -0.721310684601498 7.78538500376034e-06 NA NA NA hsa-miR-26b-5p COL12A1 -0.301646326928219 0.160081421968103 1.25452333786146 0.00320715866236616 miRNATAP -0.703444640446378 7.29704064046025e-07 NA NA NA hsa-miR-30b-5p COL12A1 -0.430720743745757 0.0593564057320791 1.25452333786146 0.00320715866236616 mirMAP -0.746331427177327 1.38945091930309e-08 NA NA NA hsa-miR-30c-5p COL12A1 -0.983130268805942 4.60419218706127e-05 1.25452333786146 0.00320715866236616 mirMAP -0.345779481535577 0.00607745443193387 NA NA NA hsa-miR-30d-3p COL12A1 -0.545113326540761 0.0433733076874155 1.25452333786146 0.00320715866236616 miRNATAP -0.575713916599858 2.30602773492062e-07 NA NA NA hsa-miR-30d-5p COL12A1 -0.5492586056147 0.0140125082460125 1.25452333786146 0.00320715866236616 mirMAP -0.777931321294368 6.12432639185186e-09 NA NA NA hsa-miR-32-5p COL12A1 0.415247682945382 0.106458022460373 1.25452333786146 0.00320715866236616 miRNATAP -0.58248038132382 7.14961254427583e-07 NA NA NA hsa-miR-326 COL12A1 -0.429748586406214 0.2629894124021 1.25452333786146 0.00320715866236616 miRanda -0.302776086781775 0.000153411334662572 NA NA NA hsa-miR-330-5p COL12A1 0.488365986827708 0.0512207630808233 1.25452333786146 0.00320715866236616 miRanda -0.360262876526508 0.0034240628700247 NA NA NA hsa-miR-338-3p COL12A1 -0.959276231066179 0.0191473351014091 1.25452333786146 0.00320715866236616 miRanda -0.233389490039334 0.00163882770156866 NA NA NA hsa-miR-375 COL12A1 -2.94506033785642 0.00570147601654791 1.25452333786146 0.00320715866236616 miRNAWalker2_validate -0.159682415175871 5.547007099933e-09 NA NA NA hsa-miR-497-5p COL12A1 -0.801030912431774 0.00360386743876612 1.25452333786146 0.00320715866236616 MirTarget;miRNATAP -0.290866738269993 0.0089346611758386 NA NA NA hsa-miR-502-3p COL12A1 -0.16442685491191 0.557471818466728 1.25452333786146 0.00320715866236616 PITA -0.49309895046378 5.35877671710557e-06 NA NA NA hsa-miR-532-5p COL12A1 0.313080805824184 0.252248939356301 1.25452333786146 0.00320715866236616 PITA -0.438734296722985 8.67814896424686e-05 NA NA NA hsa-miR-577 COL12A1 0.911619788986754 0.2256062124148 1.25452333786146 0.00320715866236616 mirMAP -0.162290305293865 7.7345437957731e-05 NA NA NA hsa-miR-29a-3p COL16A1 -0.113012156986374 0.615005009685815 0.14089966968269 0.731643507319308 miRNATAP -0.518025993436589 7.68673908213498e-05 NA NA NA hsa-miR-29b-3p COL16A1 -0.230693226193598 0.367461626035234 0.14089966968269 0.731643507319308 miRNATAP -0.44711123711595 9.21322716732238e-05 NA NA NA hsa-miR-486-5p COL16A1 -0.627607241830911 0.155274583521138 0.14089966968269 0.731643507319308 miRanda -0.1790612350388 0.00670213777800998 NA NA NA hsa-miR-107 COL1A1 0.904627575346218 4.67936495073904e-05 2.44985066495142 5.43143580547488e-06 PITA;miRanda -0.531214508146817 0.00257806895179595 NA NA NA hsa-miR-126-5p COL1A1 0.41765430251855 0.0753161203651532 2.44985066495142 5.43143580547488e-06 miRNATAP -0.753090862100838 6.39436351324928e-06 NA NA NA hsa-miR-150-5p COL1A1 0.147461377429675 0.753719621305461 2.44985066495142 5.43143580547488e-06 miRNATAP -0.476421516526796 3.83003056172264e-09 NA NA NA hsa-miR-29a-3p COL1A1 -0.113012156986374 0.615005009685815 2.44985066495142 5.43143580547488e-06 miRNATAP -0.699062359226651 7.45880252084221e-05 NA NA NA hsa-miR-29b-3p COL1A1 -0.230693226193598 0.367461626035234 2.44985066495142 5.43143580547488e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.577325260819259 0.000182556163100156 NA NA NA hsa-miR-29c-3p COL1A1 -1.62454036584589 5.38376515586029e-07 2.44985066495142 5.43143580547488e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.673130166732297 3.81716703219766e-09 NA NA NA hsa-miR-30a-3p COL1A1 -1.73205137750899 3.2425754511091e-07 2.44985066495142 5.43143580547488e-06 mirMAP -0.435142164103091 9.83389874226104e-05 NA NA NA hsa-miR-30b-3p COL1A1 -0.266398938200332 0.400847813143994 2.44985066495142 5.43143580547488e-06 miRNATAP -0.603741825545753 7.66476858464093e-07 NA NA NA hsa-miR-30d-3p COL1A1 -0.545113326540761 0.0433733076874155 2.44985066495142 5.43143580547488e-06 mirMAP -0.731086191946979 3.32575296280113e-07 NA NA NA hsa-miR-30e-3p COL1A1 -0.913131357083321 7.29096855615228e-06 2.44985066495142 5.43143580547488e-06 mirMAP -0.872215464994674 4.10971398434479e-06 NA NA NA hsa-miR-330-3p COL1A1 0.798460296022179 0.00746538156533435 2.44985066495142 5.43143580547488e-06 mirMAP -0.369102192026523 0.00504860507912315 NA NA NA hsa-miR-338-3p COL1A1 -0.959276231066179 0.0191473351014091 2.44985066495142 5.43143580547488e-06 miRanda;miRNATAP -0.477451368770203 3.13792963252951e-07 NA NA NA hsa-miR-361-3p COL1A1 -0.126462931388735 0.566052688733137 2.44985066495142 5.43143580547488e-06 PITA -0.724495257845556 5.692363025982e-05 NA NA NA hsa-miR-532-3p COL1A1 0.552364451472481 0.0975490365586023 2.44985066495142 5.43143580547488e-06 PITA;miRNATAP -0.402588648619499 0.00061988226019049 NA NA NA hsa-miR-577 COL1A1 0.911619788986754 0.2256062124148 2.44985066495142 5.43143580547488e-06 MirTarget;PITA;miRNATAP -0.160048539032184 0.00264866530502343 NA NA NA hsa-miR-625-5p COL1A1 0.537211086526376 0.203801009380384 2.44985066495142 5.43143580547488e-06 MirTarget -0.305320767653657 0.0010453631778075 NA NA NA hsa-miR-26a-5p COL1A2 -0.384110714440647 0.0442498636014044 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.593262371155885 0.00159961873628197 NA NA NA hsa-miR-26b-5p COL1A2 -0.301646326928219 0.160081421968103 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.702153351679571 2.01262856430147e-05 NA NA NA hsa-miR-29a-3p COL1A2 -0.113012156986374 0.615005009685815 1.30228102636561 0.00792817626515194 miRNATAP -0.695746281077265 9.46182551434364e-06 NA NA NA hsa-miR-29b-3p COL1A2 -0.230693226193598 0.367461626035234 1.30228102636561 0.00792817626515194 miRNATAP -0.576142965287313 2.74551822471994e-05 NA NA NA hsa-miR-29c-3p COL1A2 -1.62454036584589 5.38376515586029e-07 1.30228102636561 0.00792817626515194 miRNAWalker2_validate;miRTarBase;miRNATAP -0.533282042743308 2.40283453559017e-07 NA NA NA hsa-miR-30a-3p COL1A2 -1.73205137750899 3.2425754511091e-07 1.30228102636561 0.00792817626515194 MirTarget -0.261749989138394 0.00958487120849857 NA NA NA hsa-miR-30d-3p COL1A2 -0.545113326540761 0.0433733076874155 1.30228102636561 0.00792817626515194 MirTarget -0.650804727216266 3.83141859188195e-07 NA NA NA hsa-miR-30e-3p COL1A2 -0.913131357083321 7.29096855615228e-06 1.30228102636561 0.00792817626515194 MirTarget -0.711794987349663 2.89454881388966e-05 NA NA NA hsa-miR-32-3p COL1A2 0.583525764322974 0.11837203008551 1.30228102636561 0.00792817626515194 miRNATAP -0.366111733254426 0.000518801351475772 NA NA NA hsa-miR-32-5p COL1A2 0.415247682945382 0.106458022460373 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.571753341358994 2.75777955168215e-05 NA NA NA hsa-miR-330-5p COL1A2 0.488365986827708 0.0512207630808233 1.30228102636561 0.00792817626515194 miRanda -0.454906942738119 0.00128029535393626 NA NA NA hsa-miR-33a-3p COL1A2 0.347011402017138 0.321709379745392 1.30228102636561 0.00792817626515194 MirTarget -0.406379427250253 0.00011117706081928 NA NA NA hsa-miR-3934-5p COL1A2 0.861517283620376 0.0208987307869276 1.30228102636561 0.00792817626515194 MirTarget -0.261395186154855 0.00582939121407593 NA NA NA hsa-miR-500a-5p COL1A2 0.00337014556047865 0.992120109131868 1.30228102636561 0.00792817626515194 miRNATAP -0.280016860674177 0.00692983704762767 NA NA NA hsa-miR-7-1-3p COL1A2 0.709309110750947 0.0412301737463194 1.30228102636561 0.00792817626515194 mirMAP -0.407746831884911 4.59102634248576e-05 NA NA NA hsa-miR-92a-3p COL1A2 1.2209325870225 6.8757197708107e-06 1.30228102636561 0.00792817626515194 MirTarget;miRNATAP -0.330041735970185 0.00983863964842055 NA NA NA hsa-miR-107 COL3A1 0.904627575346218 4.67936495073904e-05 1.44491162255698 0.00414446331581639 miRanda -0.618274048183348 0.000124007100346318 NA NA NA hsa-miR-128-3p COL3A1 0.98280381420517 5.77641850797209e-05 1.44491162255698 0.00414446331581639 MirTarget -0.499978244892261 0.000644797426770846 NA NA NA hsa-miR-141-5p COL3A1 2.07543489990205 6.42575039070838e-06 1.44491162255698 0.00414446331581639 MirTarget -0.265736869401178 0.000498166643945897 NA NA NA hsa-miR-186-5p COL3A1 0.149964130725901 0.434709542998771 1.44491162255698 0.00414446331581639 miRNATAP -0.616750108094401 0.00140965725121142 NA NA NA hsa-miR-29a-3p COL3A1 -0.113012156986374 0.615005009685815 1.44491162255698 0.00414446331581639 MirTarget;miRNATAP -0.655712978948934 5.36932700749111e-05 NA NA NA hsa-miR-29b-3p COL3A1 -0.230693226193598 0.367461626035234 1.44491162255698 0.00414446331581639 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.562398647650629 7.23955806860841e-05 NA NA NA hsa-miR-29c-3p COL3A1 -1.62454036584589 5.38376515586029e-07 1.44491162255698 0.00414446331581639 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.465198996686846 1.46223395521969e-05 NA NA NA hsa-miR-326 COL3A1 -0.429748586406214 0.2629894124021 1.44491162255698 0.00414446331581639 miRanda -0.309412471209482 0.0011458408096218 NA NA NA hsa-miR-330-5p COL3A1 0.488365986827708 0.0512207630808233 1.44491162255698 0.00414446331581639 miRanda -0.447453161081817 0.00211041879669537 NA NA NA hsa-miR-335-5p COL3A1 1.59953351087307 5.56170899867314e-05 1.44491162255698 0.00414446331581639 miRNAWalker2_validate -0.389627670547703 1.01133482142085e-05 NA NA NA hsa-miR-429 COL3A1 1.40182602301928 0.00900426780286475 1.44491162255698 0.00414446331581639 miRanda -0.237591932824453 0.000345118898469854 NA NA NA hsa-miR-148a-3p COL4A1 -1.53721533763578 3.55533747293117e-05 1.07015267715433 0.00177164289889366 miRNATAP -0.186981085227601 0.00399162270521003 NA NA NA hsa-miR-29a-3p COL4A1 -0.113012156986374 0.615005009685815 1.07015267715433 0.00177164289889366 miRNAWalker2_validate;miRTarBase;miRNATAP -0.338222302444329 0.00238657829982258 NA NA NA hsa-miR-29c-3p COL4A1 -1.62454036584589 5.38376515586029e-07 1.07015267715433 0.00177164289889366 miRNAWalker2_validate;miRTarBase;miRNATAP -0.358750776944718 7.27042930902539e-07 NA NA NA hsa-miR-3065-5p COL4A1 -0.241623656423063 0.633116553078159 1.07015267715433 0.00177164289889366 miRNATAP -0.173108710122076 0.000474086069880795 NA NA NA hsa-miR-99a-5p COL4A1 -1.06045199862251 0.0178432627965381 1.07015267715433 0.00177164289889366 miRNAWalker2_validate -0.280806157088145 1.33786013959461e-07 NA NA NA hsa-miR-29a-3p COL4A2 -0.113012156986374 0.615005009685815 0.471547944261182 0.160274382484754 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.315899111924612 0.00351562435250479 NA NA NA hsa-miR-29b-3p COL4A2 -0.230693226193598 0.367461626035234 0.471547944261182 0.160274382484754 miRTarBase;MirTarget;miRNATAP -0.277335098504772 0.00330580195409516 NA NA NA hsa-miR-29c-3p COL4A2 -1.62454036584589 5.38376515586029e-07 0.471547944261182 0.160274382484754 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.2813336800449 7.64216441696144e-05 NA NA NA hsa-miR-107 COL5A1 0.904627575346218 4.67936495073904e-05 1.3460305227909 0.00569347504538867 miRanda -0.523787901052707 0.000796813685183216 NA NA NA hsa-miR-192-5p COL5A1 0.0809146624034405 0.941057093528709 1.3460305227909 0.00569347504538867 miRNATAP -0.139391556521257 8.55822138817412e-06 NA NA NA hsa-miR-26a-5p COL5A1 -0.384110714440647 0.0442498636014044 1.3460305227909 0.00569347504538867 miRNATAP -0.582245490028073 0.00182484402605642 NA NA NA hsa-miR-26b-5p COL5A1 -0.301646326928219 0.160081421968103 1.3460305227909 0.00569347504538867 miRNAWalker2_validate;miRNATAP -0.626928553508141 0.00013633848106997 NA NA NA hsa-miR-29a-3p COL5A1 -0.113012156986374 0.615005009685815 1.3460305227909 0.00569347504538867 MirTarget;miRNATAP -0.620399052717948 7.6199134956455e-05 NA NA NA hsa-miR-29b-3p COL5A1 -0.230693226193598 0.367461626035234 1.3460305227909 0.00569347504538867 MirTarget;miRNATAP -0.496640567967522 0.000296335303965333 NA NA NA hsa-miR-29c-3p COL5A1 -1.62454036584589 5.38376515586029e-07 1.3460305227909 0.00569347504538867 MirTarget;miRNATAP -0.535848711213367 1.69939751100835e-07 NA NA NA hsa-miR-3065-3p COL5A1 -1.03551124329864 0.0218397494946288 1.3460305227909 0.00569347504538867 miRNATAP -0.236465152851367 0.00206634758346119 NA NA NA hsa-miR-32-5p COL5A1 0.415247682945382 0.106458022460373 1.3460305227909 0.00569347504538867 miRNATAP -0.485831322301451 0.000364828110817354 NA NA NA hsa-miR-338-5p COL5A1 -1.19659203838734 0.0100316010080496 1.3460305227909 0.00569347504538867 miRNATAP -0.280626170389218 0.000148161526233627 NA NA NA hsa-miR-7-1-3p COL5A1 0.709309110750947 0.0412301737463194 1.3460305227909 0.00569347504538867 mirMAP -0.311365617839845 0.00190076879003761 NA NA NA hsa-miR-126-5p COL5A2 0.41765430251855 0.0753161203651532 1.66515780240979 0.000191761291481445 mirMAP -0.628910695568406 4.36430074178108e-06 NA NA NA hsa-miR-148a-5p COL5A2 -0.69329616490858 0.0793012233740369 1.66515780240979 0.000191761291481445 MirTarget -0.441727077350157 2.48626815582484e-08 NA NA NA hsa-miR-29a-3p COL5A2 -0.113012156986374 0.615005009685815 1.66515780240979 0.000191761291481445 MirTarget;miRNATAP -0.608649114284812 2.54953790246229e-05 NA NA NA hsa-miR-29b-3p COL5A2 -0.230693226193598 0.367461626035234 1.66515780240979 0.000191761291481445 MirTarget;miRNATAP -0.483467460080303 0.000134287411389775 NA NA NA hsa-miR-29c-3p COL5A2 -1.62454036584589 5.38376515586029e-07 1.66515780240979 0.000191761291481445 MirTarget;miRNATAP -0.525018541841856 2.55353369325839e-08 NA NA NA hsa-miR-30a-3p COL5A2 -1.73205137750899 3.2425754511091e-07 1.66515780240979 0.000191761291481445 mirMAP -0.303464485382673 0.00100629778283179 NA NA NA hsa-miR-30e-3p COL5A2 -0.913131357083321 7.29096855615228e-06 1.66515780240979 0.000191761291481445 mirMAP -0.711832549215419 4.75658049549434e-06 NA NA NA hsa-miR-330-3p COL5A2 0.798460296022179 0.00746538156533435 1.66515780240979 0.000191761291481445 PITA -0.292963514773968 0.0067687808743362 NA NA NA hsa-miR-335-5p COL5A2 1.59953351087307 5.56170899867314e-05 1.66515780240979 0.000191761291481445 miRNATAP -0.311932639880371 8.0750135783531e-05 NA NA NA hsa-miR-338-5p COL5A2 -1.19659203838734 0.0100316010080496 1.66515780240979 0.000191761291481445 mirMAP -0.252393142126758 0.000225744722543523 NA NA NA hsa-miR-29a-3p COL5A3 -0.113012156986374 0.615005009685815 1.74638341827873 0.000134797520118717 MirTarget;miRNATAP -0.554768744104902 0.000196485627536117 NA NA NA hsa-miR-29b-3p COL5A3 -0.230693226193598 0.367461626035234 1.74638341827873 0.000134797520118717 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.564329547049655 1.23534757436881e-05 NA NA NA hsa-miR-29c-3p COL5A3 -1.62454036584589 5.38376515586029e-07 1.74638341827873 0.000134797520118717 MirTarget;miRNATAP -0.553522125378828 9.49718483901613e-09 NA NA NA hsa-miR-3065-3p COL5A3 -1.03551124329864 0.0218397494946288 1.74638341827873 0.000134797520118717 MirTarget;miRNATAP -0.231566865972947 0.00144627117784271 NA NA NA hsa-miR-326 COL5A3 -0.429748586406214 0.2629894124021 1.74638341827873 0.000134797520118717 miRanda -0.313739479289186 0.000299171121465761 NA NA NA hsa-miR-362-3p COL5A3 -0.0349414695893027 0.913780708043777 1.74638341827873 0.000134797520118717 miRanda -0.36371957742469 0.000411401209348677 NA NA NA hsa-miR-429 COL5A3 1.40182602301928 0.00900426780286475 1.74638341827873 0.000134797520118717 miRanda -0.237591976065138 8.6732300273824e-05 NA NA NA hsa-miR-625-5p COL5A3 0.537211086526376 0.203801009380384 1.74638341827873 0.000134797520118717 mirMAP -0.388694113715226 4.44166760100632e-07 NA NA NA hsa-miR-29a-3p COL6A3 -0.113012156986374 0.615005009685815 1.02093506340636 0.0267561221463991 MirTarget;miRNATAP -0.551393665476538 0.00020031413623541 NA NA NA hsa-miR-29b-3p COL6A3 -0.230693226193598 0.367461626035234 1.02093506340636 0.0267561221463991 MirTarget;miRNATAP -0.448628437956652 0.000539956200269006 NA NA NA hsa-miR-29c-3p COL6A3 -1.62454036584589 5.38376515586029e-07 1.02093506340636 0.0267561221463991 MirTarget;miRNATAP -0.400178051461403 4.42156776829868e-05 NA NA NA hsa-miR-320b COL6A3 1.11183660885284 0.000497971211648503 1.02093506340636 0.0267561221463991 miRanda -0.315115087895812 0.00202228945844703 NA NA NA hsa-miR-320c COL6A3 0.455072851945474 0.240613785444485 1.02093506340636 0.0267561221463991 miRanda -0.28805593132866 0.00346415508904016 NA NA NA hsa-miR-330-3p COL6A3 0.798460296022179 0.00746538156533435 1.02093506340636 0.0267561221463991 miRNATAP -0.429666016001509 8.41371579350842e-05 NA NA NA hsa-miR-362-3p COL6A3 -0.0349414695893027 0.913780708043777 1.02093506340636 0.0267561221463991 miRanda -0.286807999666134 0.00540034987407448 NA NA NA hsa-miR-429 COL6A3 1.40182602301928 0.00900426780286475 1.02093506340636 0.0267561221463991 miRNATAP -0.28975163575323 1.16998966961136e-06 NA NA NA hsa-miR-590-3p COL6A3 1.11654983899947 0.000160782154924864 1.02093506340636 0.0267561221463991 miRanda -0.31755010155061 0.00397506807593211 NA NA NA hsa-miR-29a-3p COL7A1 -0.113012156986374 0.615005009685815 3.58439072310621 1.15789413310187e-08 MirTarget;miRNATAP -0.690593272172897 0.00102155570698192 NA NA NA hsa-miR-29b-3p COL7A1 -0.230693226193598 0.367461626035234 3.58439072310621 1.15789413310187e-08 MirTarget;miRNATAP -0.776272924424598 1.92753820710782e-05 NA NA NA hsa-miR-29c-3p COL7A1 -1.62454036584589 5.38376515586029e-07 3.58439072310621 1.15789413310187e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.804012842843047 2.69152610597451e-09 NA NA NA hsa-miR-361-3p COL7A1 -0.126462931388735 0.566052688733137 3.58439072310621 1.15789413310187e-08 miRNATAP -1.00131572570295 2.17404134402212e-06 NA NA NA hsa-miR-106b-5p COL8A2 1.70863907461894 2.04074794107142e-08 -0.433578329499248 0.425308433238656 mirMAP -0.46417303072263 0.000140401743350119 NA NA NA hsa-miR-17-5p COL8A2 1.65862087862483 8.45603406215941e-08 -0.433578329499248 0.425308433238656 mirMAP -0.489482378125792 4.52348744055964e-05 NA NA NA hsa-miR-185-5p COL8A2 1.14351510556643 1.07346945085714e-08 -0.433578329499248 0.425308433238656 mirMAP -0.70407596724124 0.000188681370348446 NA NA NA hsa-miR-194-3p COL8A2 0.259420201261466 0.821811295418686 -0.433578329499248 0.425308433238656 MirTarget -0.309092930909347 5.44289745983559e-25 NA NA NA hsa-miR-20a-5p COL8A2 1.4503375861709 5.7813456424762e-07 -0.433578329499248 0.425308433238656 mirMAP -0.521245119372593 5.26376888935186e-05 NA NA NA hsa-miR-3127-5p COL8A2 0.98677589413294 0.00734249049849 -0.433578329499248 0.425308433238656 MirTarget -0.503978236948338 9.18219679222859e-07 NA NA NA hsa-miR-335-5p COL8A2 1.59953351087307 5.56170899867314e-05 -0.433578329499248 0.425308433238656 miRNAWalker2_validate -0.56343123767317 9.98778194544081e-10 NA NA NA hsa-miR-361-3p COL8A2 -0.126462931388735 0.566052688733137 -0.433578329499248 0.425308433238656 MirTarget;mirMAP -0.649302278486692 0.000259542127971529 NA NA NA hsa-miR-3614-5p COL8A2 1.10426689932954 0.00706308396674599 -0.433578329499248 0.425308433238656 MirTarget;miRNATAP -0.614794187011081 1.0890962140322e-11 NA NA NA hsa-miR-582-5p COL8A2 -0.448820171762719 0.134615974001015 -0.433578329499248 0.425308433238656 PITA -0.498027979589689 0.000106153252536878 NA NA NA hsa-miR-592 COL8A2 0.779567202789068 0.204498177014474 -0.433578329499248 0.425308433238656 MirTarget;PITA;miRNATAP -0.502846694554672 1.25956968864885e-15 NA NA NA hsa-miR-625-5p COL8A2 0.537211086526376 0.203801009380384 -0.433578329499248 0.425308433238656 MirTarget -0.700462610770023 2.30242475619391e-16 NA NA NA hsa-miR-23b-3p COPA -0.286465516491361 0.18664668472995 0.208873076748146 0.126747726007958 miRNAWalker2_validate -0.206666381327106 3.09041879733352e-06 NA NA NA hsa-miR-375 CRLF1 -2.94506033785642 0.00570147601654791 -1.37469996491233 0.119129697153859 miRNAWalker2_validate -0.390530242601252 1.58454537459934e-12 NA NA NA hsa-miR-149-5p CTGF 0.706277554734069 0.296848731347677 -1.47742471982237 0.000456514926161835 miRNATAP -0.153012264832564 0.00059129662846367 NA NA NA hsa-miR-16-2-3p CTGF 1.8048179609245 2.83095715136409e-09 -1.47742471982237 0.000456514926161835 MirTarget -0.679580410767606 7.12759308813084e-14 NA NA NA hsa-miR-18a-5p CTGF 2.20211504140984 1.78678887916334e-09 -1.47742471982237 0.000456514926161835 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.383153713276625 9.14496065795554e-07 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 1.26669687448473 0.000105972838514412 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.357350420170976 8.58849496642616e-05 NA NA NA hsa-miR-19b-3p CTGF 0.759818275708988 0.00652779573186786 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.417275867420144 0.000111520843196417 NA NA NA hsa-miR-26b-3p CTGF -0.0103961389461977 0.965770899625511 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.493173752411661 9.45407994366529e-05 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-26b-5p CTGF -0.301646326928219 0.160081421968103 -1.47742471982237 0.000456514926161835 miRNATAP -0.38771125707237 0.00727109512481099 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-3065-5p CTGF -0.241623656423063 0.633116553078159 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.252381747273136 3.35401318339972e-05 NA NA NA hsa-miR-330-3p CTGF 0.798460296022179 0.00746538156533435 -1.47742471982237 0.000456514926161835 MirTarget;PITA;miRNATAP -0.428513987299392 2.00855570170052e-05 NA NA NA hsa-miR-3662 CTGF 1.82780708047676 0.0054036501346178 -1.47742471982237 0.000456514926161835 MirTarget;miRNATAP -0.17047411695915 0.00404607160545695 NA NA NA hsa-miR-577 CTGF 0.911619788986754 0.2256062124148 -1.47742471982237 0.000456514926161835 miRNATAP -0.122641018049418 0.00291470486504945 NA NA NA hsa-miR-590-3p CTGF 1.11654983899947 0.000160782154924864 -1.47742471982237 0.000456514926161835 PITA;miRanda -0.450291396404158 7.02135050790325e-06 NA NA NA hsa-miR-30a-5p CTHRC1 -1.71922855140016 3.20574349285256e-07 3.59790877148997 2.79608438107054e-13 MirTarget -0.381004785626852 0.00039890184039999 NA NA NA hsa-miR-30b-5p CTHRC1 -0.430720743745757 0.0593564057320791 3.59790877148997 2.79608438107054e-13 MirTarget -0.706616382909855 1.61152749737371e-05 26388700 MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; Bioinformatics analysis identified Cthrc1 as a target of miR-30b and western blotting and luciferase reporter assays confirmed that miR-30b regulates Cthrc1 by directly binding to its 3'UTR; Transfection of Cthrc1 without the 3'UTR restored the miR-30b inhibiting cell invasion; Up-regulation of miR-30b or down-regulation of Cthrc1 had potential significance in the invasion and metastasis of NSCLC; MiR-30b was down-regulated and Cthrc1 up-regulated in NSCLC tissues; MiR-30b affected NSCLC cells invasion and migration by regulating Cthrc1 metastasis lung squamous cell cancer hsa-miR-30c-5p CTHRC1 -0.983130268805942 4.60419218706127e-05 3.59790877148997 2.79608438107054e-13 MirTarget -0.512997145160849 0.000837919858022893 NA NA NA hsa-miR-30d-5p CTHRC1 -0.5492586056147 0.0140125082460125 3.59790877148997 2.79608438107054e-13 MirTarget -0.907995572726828 3.42138602528991e-08 NA NA NA hsa-miR-30e-5p CTHRC1 -0.573784818166736 0.0112497802572927 3.59790877148997 2.79608438107054e-13 MirTarget -0.567044744906885 0.000648458112722411 NA NA NA hsa-miR-1271-5p CXCL12 1.15538250415776 0.00207865862606828 -2.24587413785221 3.87322996546498e-06 mirMAP -0.25050031278078 0.00851760433105513 NA NA NA hsa-miR-141-3p CXCL12 1.45548825076434 0.00115958850961764 -2.24587413785221 3.87322996546498e-06 miRNATAP -0.525665982261786 1.3981175845771e-12 NA NA NA hsa-miR-16-2-3p CXCL12 1.8048179609245 2.83095715136409e-09 -2.24587413785221 3.87322996546498e-06 mirMAP -0.635811042423956 5.34669508302412e-09 NA NA NA hsa-miR-200a-3p CXCL12 0.717826667295984 0.193912116506827 -2.24587413785221 3.87322996546498e-06 miRNATAP -0.308841307756219 8.54502812887588e-07 NA NA NA hsa-miR-221-3p CXCL12 1.33496247538338 3.82022531235275e-07 -2.24587413785221 3.87322996546498e-06 MirTarget -0.686482449870367 9.94991990915955e-08 NA NA NA hsa-miR-222-3p CXCL12 1.39382731585819 9.98182478024671e-07 -2.24587413785221 3.87322996546498e-06 MirTarget -0.653112932175076 3.64975350074537e-08 NA NA NA hsa-miR-23a-3p CXCL12 1.10685926969665 3.16223452471768e-08 -2.24587413785221 3.87322996546498e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.770502098886683 7.58244017908966e-06 25322765 MiR-23a suppressed the transcription of RUNX2 and CXCL12 by binding to the 3' UTRs of these mRNAs; The cellular function of miR-23a is RUNX2/CXCL12-dependent and the overexpression of RUNX2 or CXCL12 rescued the impaired cell growth migration and invasion induced by miR-23a sarcoma hsa-miR-301a-3p CXCL12 1.44721900431161 6.35068481036652e-06 -2.24587413785221 3.87322996546498e-06 miRNATAP -0.4423827887634 3.7924812948442e-05 NA NA NA hsa-miR-31-5p CXCL12 0.666358292391859 0.381800494600846 -2.24587413785221 3.87322996546498e-06 miRNAWalker2_validate -0.302887457634608 1.07227693653852e-10 NA NA NA hsa-miR-320a CXCL12 0.593888711838028 0.011897419390526 -2.24587413785221 3.87322996546498e-06 miRanda -0.419658980514121 0.0056687966007718 NA NA NA hsa-miR-320b CXCL12 1.11183660885284 0.000497971211648503 -2.24587413785221 3.87322996546498e-06 miRanda -0.495307384999476 4.90784623566632e-06 NA NA NA hsa-miR-320c CXCL12 0.455072851945474 0.240613785444485 -2.24587413785221 3.87322996546498e-06 miRanda -0.278728541284853 0.00881416066209492 NA NA NA hsa-miR-429 CXCL12 1.40182602301928 0.00900426780286475 -2.24587413785221 3.87322996546498e-06 miRanda;miRNATAP -0.387075158986044 8.61041610512618e-10 NA NA NA hsa-miR-455-5p CXCL12 1.20462751989145 6.74386011867484e-05 -2.24587413785221 3.87322996546498e-06 miRanda -0.499744559364851 1.24883682212993e-05 NA NA NA hsa-miR-590-3p CXCL12 1.11654983899947 0.000160782154924864 -2.24587413785221 3.87322996546498e-06 PITA;miRanda;mirMAP -0.373614697306884 0.00162580166158087 NA NA NA hsa-miR-629-3p CXCL12 1.40326397107309 9.7803063526732e-05 -2.24587413785221 3.87322996546498e-06 MirTarget -0.496621946360401 1.57352194761477e-07 NA NA NA hsa-miR-96-5p CXCL12 1.14243043653372 0.00942969392739105 -2.24587413785221 3.87322996546498e-06 mirMAP -0.524636633662188 6.9367614205992e-11 NA NA NA hsa-miR-1-3p CXCL6 -2.66410453456934 1.50620580537836e-05 3.52782326391651 9.92442877769238e-07 MirTarget -0.327858870561131 7.97243300576568e-05 NA NA NA hsa-miR-129-5p CXCL6 -2.56914016541176 2.36237896095709e-06 3.52782326391651 9.92442877769238e-07 miRanda -0.319844782516276 0.000826705805214876 NA NA NA hsa-miR-32-3p CYR61 0.583525764322974 0.11837203008551 -0.547400483583481 0.167739443324764 miRNATAP -0.32816331121 0.000100718613455214 NA NA NA hsa-miR-429 CYR61 1.40182602301928 0.00900426780286475 -0.547400483583481 0.167739443324764 miRanda -0.343574826878623 4.09279720709708e-12 NA NA NA hsa-miR-106a-5p DAB2 -0.173255688252641 0.642872703263671 0.374807015487456 0.257785729144383 MirTarget;miRNATAP -0.193949887538358 0.0021094153238487 NA NA NA hsa-miR-106b-5p DAB2 1.70863907461894 2.04074794107142e-08 0.374807015487456 0.257785729144383 MirTarget;miRNATAP -0.215472305747942 0.00395534255508643 26769181 The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR western blot and immunohistochemistry; DAB2 a predicted target gene of miR-106b was inhibited by TGF-β1 partly through miR-106b and was involved in TGF-β1-induced cervical cancer cell migration; The expression of DAB2 was low in cervical cancer tissues and negatively correlated with miR-106b expression cell migration cervical and endocervical cancer hsa-miR-149-5p DAB2 0.706277554734069 0.296848731347677 0.374807015487456 0.257785729144383 miRNATAP -0.114840074928928 0.00087298625135471 NA NA NA hsa-miR-17-5p DAB2 1.65862087862483 8.45603406215941e-08 0.374807015487456 0.257785729144383 MirTarget;TargetScan;miRNATAP -0.197931105877102 0.00740731632716651 NA NA NA hsa-miR-203a-3p DAB2 1.44736908507496 0.0394116388736904 0.374807015487456 0.257785729144383 MirTarget -0.209187334412586 4.60872680446535e-11 NA NA NA hsa-miR-26b-5p DAB2 -0.301646326928219 0.160081421968103 0.374807015487456 0.257785729144383 miRNAWalker2_validate -0.350885386694485 0.00163391431645692 NA NA NA hsa-miR-320b DAB2 1.11183660885284 0.000497971211648503 0.374807015487456 0.257785729144383 PITA;miRanda;miRNATAP -0.209654204518496 0.00409867873663742 NA NA NA hsa-miR-320c DAB2 0.455072851945474 0.240613785444485 0.374807015487456 0.257785729144383 PITA;miRanda;miRNATAP -0.194031812261712 0.00590238058447497 NA NA NA hsa-miR-590-5p DAB2 1.04171442093217 0.000272475544954865 0.374807015487456 0.257785729144383 miRanda -0.241366045722889 0.00308084466113401 NA NA NA hsa-miR-96-5p DAB2 1.14243043653372 0.00942969392739105 0.374807015487456 0.257785729144383 MirTarget;TargetScan -0.270155575409783 7.31894243910281e-07 NA NA NA hsa-let-7d-5p DCN 0.981733854788227 7.26366577706469e-07 -1.60275664174823 0.00032445659344853 MirTarget -0.724728413499519 5.00044895616597e-06 NA NA NA hsa-miR-142-5p DCN 1.55592486377018 6.69269968016779e-06 -1.60275664174823 0.00032445659344853 mirMAP -0.343015257594815 0.000151081708352864 NA NA NA hsa-miR-181b-5p DCN 1.64216500592669 1.89228845300725e-08 -1.60275664174823 0.00032445659344853 MirTarget -0.338039363564562 0.00150729107068411 NA NA NA hsa-miR-186-5p DCN 0.149964130725901 0.434709542998771 -1.60275664174823 0.00032445659344853 mirMAP -0.69891235873009 4.10536218684032e-05 NA NA NA hsa-miR-3065-5p DCN -0.241623656423063 0.633116553078159 -1.60275664174823 0.00032445659344853 mirMAP -0.206631945751628 0.00148032909765992 NA NA NA hsa-miR-320a DCN 0.593888711838028 0.011897419390526 -1.60275664174823 0.00032445659344853 miRanda -0.534506307807135 8.69384497232099e-05 NA NA NA hsa-miR-320b DCN 1.11183660885284 0.000497971211648503 -1.60275664174823 0.00032445659344853 miRanda -0.505006015025399 2.2710625392682e-07 NA NA NA hsa-miR-320c DCN 0.455072851945474 0.240613785444485 -1.60275664174823 0.00032445659344853 miRanda -0.34315498800131 0.000339054247241317 NA NA NA hsa-miR-374b-3p DCN 0.999491658196932 0.00126937019814872 -1.60275664174823 0.00032445659344853 MirTarget -0.357788072116761 0.00104760669529638 NA NA NA hsa-miR-421 DCN 1.80720854070385 1.59709651202848e-07 -1.60275664174823 0.00032445659344853 miRanda -0.34295303532882 0.000135414354904695 NA NA NA hsa-miR-501-5p DCN 0.266919328110625 0.454779001968586 -1.60275664174823 0.00032445659344853 mirMAP -0.350395709836513 9.30735249860743e-05 NA NA NA hsa-miR-590-3p DCN 1.11654983899947 0.000160782154924864 -1.60275664174823 0.00032445659344853 MirTarget;PITA;miRanda;mirMAP -0.506161135214916 1.69399226222161e-06 NA NA NA hsa-miR-7-1-3p DCN 0.709309110750947 0.0412301737463194 -1.60275664174823 0.00032445659344853 mirMAP -0.501549264411452 2.44449822557721e-08 NA NA NA hsa-miR-107 DPYSL3 0.904627575346218 4.67936495073904e-05 -0.821240351033374 0.0993269632569678 miRanda -0.843011839967563 5.57255273210509e-08 NA NA NA hsa-miR-1266-5p DPYSL3 0.214881660714884 0.741561405223711 -0.821240351033374 0.0993269632569678 MirTarget -0.400283522704149 9.24360633576479e-15 NA NA NA hsa-miR-141-3p DPYSL3 1.45548825076434 0.00115958850961764 -0.821240351033374 0.0993269632569678 TargetScan -0.574761564894957 4.11306751939882e-15 NA NA NA hsa-miR-141-5p DPYSL3 2.07543489990205 6.42575039070838e-06 -0.821240351033374 0.0993269632569678 MirTarget -0.470515516140904 6.70075119589625e-11 NA NA NA hsa-miR-197-3p DPYSL3 0.888854270009261 0.000195183808214449 -0.821240351033374 0.0993269632569678 miRNAWalker2_validate -0.575209975120593 9.34431329376375e-05 NA NA NA hsa-miR-25-3p DPYSL3 1.00604871526544 0.000421838061147906 -0.821240351033374 0.0993269632569678 mirMAP -0.432704610049691 0.000437111632598824 NA NA NA hsa-miR-26b-5p DPYSL3 -0.301646326928219 0.160081421968103 -0.821240351033374 0.0993269632569678 miRNAWalker2_validate -0.574459286380461 0.000616998777941833 NA NA NA hsa-miR-29a-3p DPYSL3 -0.113012156986374 0.615005009685815 -0.821240351033374 0.0993269632569678 MirTarget -0.4525285949781 0.00497338186615159 NA NA NA hsa-miR-29b-3p DPYSL3 -0.230693226193598 0.367461626035234 -0.821240351033374 0.0993269632569678 MirTarget -0.56666244161639 4.5534359678227e-05 NA NA NA hsa-miR-31-3p DPYSL3 0.474904754927656 0.506866261575484 -0.821240351033374 0.0993269632569678 MirTarget -0.141205886055245 0.00466428202452124 NA NA NA hsa-miR-320a DPYSL3 0.593888711838028 0.011897419390526 -0.821240351033374 0.0993269632569678 miRNATAP -0.464440021986018 0.00216564391909315 NA NA NA hsa-miR-320b DPYSL3 1.11183660885284 0.000497971211648503 -0.821240351033374 0.0993269632569678 miRNATAP -0.454218035702022 3.06790456778507e-05 NA NA NA hsa-miR-320c DPYSL3 0.455072851945474 0.240613785444485 -0.821240351033374 0.0993269632569678 miRNATAP -0.407549701367175 0.000110017569463129 NA NA NA hsa-miR-330-3p DPYSL3 0.798460296022179 0.00746538156533435 -0.821240351033374 0.0993269632569678 MirTarget;PITA;miRNATAP -0.431626703522892 0.000258660059128521 NA NA NA hsa-miR-335-3p DPYSL3 2.5197689063267 2.20084506976733e-09 -0.821240351033374 0.0993269632569678 mirMAP -0.46294013831624 2.96018760819416e-09 NA NA NA hsa-miR-338-5p DPYSL3 -1.19659203838734 0.0100316010080496 -0.821240351033374 0.0993269632569678 PITA -0.274874012040784 0.000263680453225235 NA NA NA hsa-miR-362-3p DPYSL3 -0.0349414695893027 0.913780708043777 -0.821240351033374 0.0993269632569678 PITA;miRanda;miRNATAP -0.521526652839721 1.72126441526947e-06 NA NA NA hsa-miR-3662 DPYSL3 1.82780708047676 0.0054036501346178 -0.821240351033374 0.0993269632569678 mirMAP -0.293119529633087 1.82014246052854e-05 NA NA NA hsa-miR-375 DPYSL3 -2.94506033785642 0.00570147601654791 -0.821240351033374 0.0993269632569678 miRNAWalker2_validate -0.202403842587554 1.39837102587194e-10 NA NA NA hsa-miR-423-3p DPYSL3 0.817576939524592 0.000261533454265696 -0.821240351033374 0.0993269632569678 miRNAWalker2_validate -0.800027038313001 2.51966098782509e-07 NA NA NA hsa-miR-532-3p DPYSL3 0.552364451472481 0.0975490365586023 -0.821240351033374 0.0993269632569678 miRNATAP -0.820276307378004 1.15760525136483e-16 NA NA NA hsa-miR-589-5p DPYSL3 0.702695092403762 0.00395772685954799 -0.821240351033374 0.0993269632569678 mirMAP -0.625266269679552 1.47551278381456e-05 NA NA NA hsa-miR-590-3p DPYSL3 1.11654983899947 0.000160782154924864 -0.821240351033374 0.0993269632569678 miRanda;mirMAP -0.469841126038476 6.57994639056971e-05 NA NA NA hsa-miR-616-5p DPYSL3 0.834052908652744 0.0347835664029363 -0.821240351033374 0.0993269632569678 mirMAP -0.41762207437466 3.32008640898738e-06 NA NA NA hsa-let-7f-5p DST 0.634633924115866 0.0344982923411787 -0.242171382446708 0.521397916698887 miRNATAP -0.332899229080576 0.000180879449763491 NA NA NA hsa-let-7g-5p DST 0.325297685027927 0.241142963826631 -0.242171382446708 0.521397916698887 miRNATAP -0.519728498413335 4.2152600574248e-08 NA NA NA hsa-miR-101-3p DST -0.451263906815861 0.0283387250173031 -0.242171382446708 0.521397916698887 mirMAP -0.413269311782407 0.00178697027688725 NA NA NA hsa-miR-106b-5p DST 1.70863907461894 2.04074794107142e-08 -0.242171382446708 0.521397916698887 mirMAP -0.227194042975489 0.00777626547793866 NA NA NA hsa-miR-126-5p DST 0.41765430251855 0.0753161203651532 -0.242171382446708 0.521397916698887 mirMAP -0.317264857496611 0.00613743841070563 NA NA NA hsa-miR-140-5p DST 0.208193069681326 0.303002433893804 -0.242171382446708 0.521397916698887 mirMAP -0.451766929149303 0.000841035399584176 NA NA NA hsa-miR-150-5p DST 0.147461377429675 0.753719621305461 -0.242171382446708 0.521397916698887 mirMAP -0.181338752364564 0.00144918583897846 NA NA NA hsa-miR-17-3p DST 1.31126744284937 3.24768335024185e-07 -0.242171382446708 0.521397916698887 mirMAP;miRNATAP -0.427259554350718 2.37686857759231e-05 NA NA NA hsa-miR-186-5p DST 0.149964130725901 0.434709542998771 -0.242171382446708 0.521397916698887 mirMAP -0.536545682332854 0.000165658895431581 NA NA NA hsa-miR-18a-5p DST 2.20211504140984 1.78678887916334e-09 -0.242171382446708 0.521397916698887 mirMAP -0.187217352451552 0.00780017205592149 NA NA NA hsa-miR-192-5p DST 0.0809146624034405 0.941057093528709 -0.242171382446708 0.521397916698887 miRNAWalker2_validate;mirMAP -0.205969868248228 1.38944765238267e-20 NA NA NA hsa-miR-19b-1-5p DST 1.38738648038895 1.3113681938066e-06 -0.242171382446708 0.521397916698887 mirMAP -0.307737158136051 0.000744973363715508 NA NA NA hsa-miR-200a-3p DST 0.717826667295984 0.193912116506827 -0.242171382446708 0.521397916698887 mirMAP -0.188727680810429 8.24228091167876e-05 NA NA NA hsa-miR-200b-3p DST 0.974577911407732 0.0595020056914543 -0.242171382446708 0.521397916698887 mirMAP -0.196294846097021 0.00012509158022938 NA NA NA hsa-miR-215-5p DST 0.715250240418615 0.573784317311889 -0.242171382446708 0.521397916698887 miRNAWalker2_validate -0.171647756569616 3.82866760440818e-19 NA NA NA hsa-miR-26a-5p DST -0.384110714440647 0.0442498636014044 -0.242171382446708 0.521397916698887 miRNAWalker2_validate;mirMAP;miRNATAP -0.457732648180852 0.00140827589958527 NA NA NA hsa-miR-30d-3p DST -0.545113326540761 0.0433733076874155 -0.242171382446708 0.521397916698887 mirMAP -0.29404564690639 0.00326201069171345 NA NA NA hsa-miR-32-5p DST 0.415247682945382 0.106458022460373 -0.242171382446708 0.521397916698887 miRNAWalker2_validate;mirMAP -0.4303468613764 3.56296030856226e-05 NA NA NA hsa-miR-320a DST 0.593888711838028 0.011897419390526 -0.242171382446708 0.521397916698887 mirMAP -0.3320583366805 0.00373171166986767 NA NA NA hsa-miR-320b DST 1.11183660885284 0.000497971211648503 -0.242171382446708 0.521397916698887 mirMAP -0.309360271805635 0.000181218882302399 NA NA NA hsa-miR-326 DST -0.429748586406214 0.2629894124021 -0.242171382446708 0.521397916698887 miRanda;mirMAP -0.273503540196236 9.56730130856291e-05 NA NA NA hsa-miR-330-3p DST 0.798460296022179 0.00746538156533435 -0.242171382446708 0.521397916698887 mirMAP -0.251209162156772 0.00517048504384196 NA NA NA hsa-miR-335-3p DST 2.5197689063267 2.20084506976733e-09 -0.242171382446708 0.521397916698887 mirMAP -0.171446263692396 0.00494120660965641 NA NA NA hsa-miR-335-5p DST 1.59953351087307 5.56170899867314e-05 -0.242171382446708 0.521397916698887 miRNAWalker2_validate -0.274960615322071 2.75529314223166e-05 NA NA NA hsa-miR-362-5p DST -0.354508685915981 0.354912078595613 -0.242171382446708 0.521397916698887 TargetScan;mirMAP -0.337339431525145 9.16705109554934e-07 NA NA NA hsa-miR-378c DST -1.27752074861415 2.73676010235611e-05 -0.242171382446708 0.521397916698887 mirMAP -0.490643215925303 5.06916361012887e-09 NA NA NA hsa-miR-3934-5p DST 0.861517283620376 0.0208987307869276 -0.242171382446708 0.521397916698887 mirMAP -0.230160027890096 0.00140730736988281 NA NA NA hsa-miR-429 DST 1.40182602301928 0.00900426780286475 -0.242171382446708 0.521397916698887 miRanda;mirMAP;miRNATAP -0.174872473520467 0.000381183981101152 NA NA NA hsa-miR-500a-3p DST 0.133193057420744 0.668896091969871 -0.242171382446708 0.521397916698887 mirMAP -0.311565228744469 0.000300656776534386 NA NA NA hsa-miR-532-3p DST 0.552364451472481 0.0975490365586023 -0.242171382446708 0.521397916698887 mirMAP -0.449470700706757 8.69738596758136e-09 NA NA NA hsa-miR-532-5p DST 0.313080805824184 0.252248939356301 -0.242171382446708 0.521397916698887 mirMAP -0.633642620722461 1.99998870565611e-11 NA NA NA hsa-miR-550a-5p DST 2.27360629906903 2.14504977831873e-07 -0.242171382446708 0.521397916698887 mirMAP -0.180018286137399 0.0024554604742276 NA NA NA hsa-miR-577 DST 0.911619788986754 0.2256062124148 -0.242171382446708 0.521397916698887 PITA -0.178376966441512 5.4138338187391e-07 NA NA NA hsa-miR-592 DST 0.779567202789068 0.204498177014474 -0.242171382446708 0.521397916698887 mirMAP -0.275869734689266 9.21537911008776e-10 NA NA NA hsa-miR-1296-5p ECM2 1.24127275671822 0.000834150627135999 -0.251995905696044 0.445320163344086 MirTarget -0.180622116474607 0.00379917047411306 NA NA NA hsa-miR-16-2-3p ECM2 1.8048179609245 2.83095715136409e-09 -0.251995905696044 0.445320163344086 mirMAP -0.343458405508442 2.55648862787841e-06 NA NA NA hsa-miR-3065-5p ECM2 -0.241623656423063 0.633116553078159 -0.251995905696044 0.445320163344086 mirMAP -0.186641900820087 7.11450763299818e-05 NA NA NA hsa-miR-320a ECM2 0.593888711838028 0.011897419390526 -0.251995905696044 0.445320163344086 miRanda -0.338063842048927 0.000692911521126661 NA NA NA hsa-miR-320b ECM2 1.11183660885284 0.000497971211648503 -0.251995905696044 0.445320163344086 miRanda -0.31178413917399 1.39196216259262e-05 NA NA NA hsa-miR-320c ECM2 0.455072851945474 0.240613785444485 -0.251995905696044 0.445320163344086 miRanda -0.251132716637675 0.00031473398892164 NA NA NA hsa-miR-335-3p ECM2 2.5197689063267 2.20084506976733e-09 -0.251995905696044 0.445320163344086 MirTarget -0.195277738369894 0.000223337947163294 NA NA NA hsa-miR-452-3p ECM2 2.2028815467959 0.00185370432491004 -0.251995905696044 0.445320163344086 MirTarget -0.119421191545169 0.00115903719963495 NA NA NA hsa-miR-590-3p ECM2 1.11654983899947 0.000160782154924864 -0.251995905696044 0.445320163344086 MirTarget;miRanda;miRNATAP -0.278447249183856 0.00035650623925282 NA NA NA hsa-miR-590-5p ECM2 1.04171442093217 0.000272475544954865 -0.251995905696044 0.445320163344086 miRanda -0.402471924166956 4.12068510053199e-07 NA NA NA hsa-miR-7-1-3p ECM2 0.709309110750947 0.0412301737463194 -0.251995905696044 0.445320163344086 MirTarget -0.207231225128532 0.00207636774456198 NA NA NA hsa-let-7a-3p EDIL3 0.503048155002889 0.0411145454335299 -1.08450666098937 0.0363169841456093 MirTarget -0.402022221300459 0.00814148253609281 NA NA NA hsa-miR-107 EDIL3 0.904627575346218 4.67936495073904e-05 -1.08450666098937 0.0363169841456093 miRanda -0.641179895850671 9.89954369820321e-05 NA NA NA hsa-miR-16-2-3p EDIL3 1.8048179609245 2.83095715136409e-09 -1.08450666098937 0.0363169841456093 mirMAP -0.398859258064657 0.000643940955290829 NA NA NA hsa-miR-186-5p EDIL3 0.149964130725901 0.434709542998771 -1.08450666098937 0.0363169841456093 mirMAP -0.579071257763441 0.00345410874033932 NA NA NA hsa-miR-212-3p EDIL3 0.960352937108106 0.00133449812322732 -1.08450666098937 0.0363169841456093 MirTarget -0.323078183746245 0.00895432477328212 NA NA NA hsa-miR-29b-1-5p EDIL3 0.606560155953522 0.116355599574769 -1.08450666098937 0.0363169841456093 MirTarget -0.258506678338945 0.00720232921243848 NA NA NA hsa-miR-323b-3p EDIL3 1.13581624461921 0.0214847831286342 -1.08450666098937 0.0363169841456093 MirTarget -0.244012840236046 0.00373902714570974 NA NA NA hsa-miR-361-5p EDIL3 0.407725414130987 0.0181260969156347 -1.08450666098937 0.0363169841456093 MirTarget;miRanda -0.602865843835452 0.00636014910899319 NA NA NA hsa-miR-590-3p EDIL3 1.11654983899947 0.000160782154924864 -1.08450666098937 0.0363169841456093 miRanda;mirMAP -0.347163860536884 0.00509854750752272 NA NA NA hsa-miR-590-5p EDIL3 1.04171442093217 0.000272475544954865 -1.08450666098937 0.0363169841456093 MirTarget;miRNATAP -0.500807653875653 8.21888165617002e-05 NA NA NA hsa-miR-940 EDIL3 1.64406174271686 0.000690854900107004 -1.08450666098937 0.0363169841456093 MirTarget;PITA -0.305498021165176 0.000574094619870434 NA NA NA hsa-miR-128-3p EFEMP2 0.98280381420517 5.77641850797209e-05 -0.48013938059535 0.184671687195979 miRNAWalker2_validate -0.349473459268842 0.0008071934278391 NA NA NA hsa-miR-330-5p EFEMP2 0.488365986827708 0.0512207630808233 -0.48013938059535 0.184671687195979 miRanda -0.439025185678763 1.79885115522172e-05 NA NA NA hsa-miR-629-3p EFEMP2 1.40326397107309 9.7803063526732e-05 -0.48013938059535 0.184671687195979 MirTarget -0.273161073695201 9.0004784461643e-05 NA NA NA hsa-miR-144-3p ELN -0.13309578176575 0.798245647923351 -1.46025986583619 0.013425300280123 miRNATAP -0.413647257215915 2.48461333708323e-07 NA NA NA hsa-miR-331-3p ELN 1.04880525429426 9.99995355989124e-05 -1.46025986583619 0.013425300280123 MirTarget;PITA -0.848236167174441 1.97798657854105e-08 NA NA NA hsa-miR-3614-5p ELN 1.10426689932954 0.00706308396674599 -1.46025986583619 0.013425300280123 mirMAP -0.328342921169346 0.00153146346967998 NA NA NA hsa-miR-421 ELN 1.80720854070385 1.59709651202848e-07 -1.46025986583619 0.013425300280123 miRanda -0.338411286860749 0.00448667427929272 NA NA NA hsa-miR-429 ELN 1.40182602301928 0.00900426780286475 -1.46025986583619 0.013425300280123 miRNATAP -0.234594929680905 0.00263134711297567 NA NA NA hsa-miR-615-3p ELN 2.82967143704683 3.05118423223543e-05 -1.46025986583619 0.013425300280123 miRanda -0.245652122205275 0.00372415550754509 NA NA NA hsa-miR-939-5p ELN 0.857156740351386 0.0124815824643173 -1.46025986583619 0.013425300280123 MirTarget -0.639434532602416 1.38149999289617e-06 NA NA NA hsa-miR-338-3p ENO2 -0.959276231066179 0.0191473351014091 0.379049265235992 0.379944386648336 miRanda -0.303899862647545 3.76960329044767e-05 NA NA NA hsa-miR-30a-5p FAP -1.71922855140016 3.20574349285256e-07 3.33635531129603 1.50416681580598e-08 miRNATAP -0.389208006967078 0.00199273776612356 NA NA NA hsa-miR-30c-5p FAP -0.983130268805942 4.60419218706127e-05 3.33635531129603 1.50416681580598e-08 miRNATAP -0.68313603283413 0.000126484844875323 NA NA NA hsa-miR-30d-5p FAP -0.5492586056147 0.0140125082460125 3.33635531129603 1.50416681580598e-08 miRNATAP -1.30995778675942 2.7514980616569e-12 NA NA NA hsa-miR-338-5p FAP -1.19659203838734 0.0100316010080496 3.33635531129603 1.50416681580598e-08 PITA;miRNATAP -0.477287509016917 1.48765998281804e-07 NA NA NA hsa-miR-375 FAP -2.94506033785642 0.00570147601654791 3.33635531129603 1.50416681580598e-08 miRanda -0.29600536253795 4.67495125556773e-15 NA NA NA hsa-miR-429 FAP 1.40182602301928 0.00900426780286475 3.33635531129603 1.50416681580598e-08 miRNATAP -0.32454157298057 4.60350183383175e-05 NA NA NA hsa-miR-106a-5p FAS -0.173255688252641 0.642872703263671 0.657268335933371 0.0207009292820455 miRNAWalker2_validate;miRTarBase -0.15547134509945 0.00429149494899305 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-129-5p FAS -2.56914016541176 2.36237896095709e-06 0.657268335933371 0.0207009292820455 miRanda -0.124419506861282 0.000695154070004086 NA NA NA hsa-miR-107 FBLN1 0.904627575346218 4.67936495073904e-05 -2.10799574858852 0.000237393086889568 miRanda -0.905523852725755 6.76904521750818e-07 NA NA NA hsa-miR-330-5p FBLN1 0.488365986827708 0.0512207630808233 -2.10799574858852 0.000237393086889568 miRanda -0.748564907992077 5.28197010083698e-06 NA NA NA hsa-miR-429 FBLN1 1.40182602301928 0.00900426780286475 -2.10799574858852 0.000237393086889568 miRanda -0.499532666829746 7.0630236555615e-12 NA NA NA hsa-miR-128-3p FBLN2 0.98280381420517 5.77641850797209e-05 -1.46374461215943 0.00609116104299891 MirTarget -0.762041141920808 5.74181470135443e-07 NA NA NA hsa-miR-335-5p FBLN2 1.59953351087307 5.56170899867314e-05 -1.46374461215943 0.00609116104299891 miRNAWalker2_validate -0.535720154201372 5.0731649879948e-09 NA NA NA hsa-miR-3662 FBLN2 1.82780708047676 0.0054036501346178 -1.46374461215943 0.00609116104299891 MirTarget;miRNATAP -0.247812361923598 0.000866262257658367 NA NA NA hsa-miR-744-5p FBLN2 1.0861545801627 0.000122087743268849 -1.46374461215943 0.00609116104299891 MirTarget -0.471832669899492 0.000406838154601041 NA NA NA hsa-miR-200c-3p FBLN5 1.28185685499076 0.00369777635539177 -1.26979470473216 0.000761622282100637 miRNAWalker2_validate;miRTarBase -0.377898852957826 9.55851588496684e-11 NA NA NA hsa-miR-330-3p FBLN5 0.798460296022179 0.00746538156533435 -1.26979470473216 0.000761622282100637 miRNATAP -0.379508316857777 2.38911749128597e-05 NA NA NA hsa-miR-335-5p FBLN5 1.59953351087307 5.56170899867314e-05 -1.26979470473216 0.000761622282100637 miRNAWalker2_validate -0.183961075372431 0.00625738296523118 NA NA NA hsa-miR-429 FBLN5 1.40182602301928 0.00900426780286475 -1.26979470473216 0.000761622282100637 miRanda;miRNATAP -0.26080196871937 9.3630140557731e-08 NA NA NA hsa-miR-616-5p FBLN5 0.834052908652744 0.0347835664029363 -1.26979470473216 0.000761622282100637 miRNATAP -0.225925662577703 0.00118269481204741 NA NA NA hsa-miR-769-5p FBLN5 1.14821899306381 1.27143750879772e-06 -1.26979470473216 0.000761622282100637 PITA -0.612072203233095 2.43107914664565e-08 NA NA NA hsa-let-7a-3p FBN1 0.503048155002889 0.0411145454335299 -0.771604345564946 0.11079433849465 mirMAP -0.572849433506193 4.1583192616724e-05 NA NA NA hsa-let-7f-1-3p FBN1 1.28704406797397 1.17954701106157e-06 -0.771604345564946 0.11079433849465 mirMAP -0.379323155893444 0.00297551469579764 NA NA NA hsa-miR-126-5p FBN1 0.41765430251855 0.0753161203651532 -0.771604345564946 0.11079433849465 mirMAP -0.637693602562221 1.37947635253302e-05 NA NA NA hsa-miR-142-3p FBN1 1.32364054836498 0.0001537753622128 -0.771604345564946 0.11079433849465 miRanda -0.272856854167581 0.00505231896471206 NA NA NA hsa-miR-16-2-3p FBN1 1.8048179609245 2.83095715136409e-09 -0.771604345564946 0.11079433849465 mirMAP -0.626809999436364 3.00888178710132e-09 NA NA NA hsa-miR-182-5p FBN1 0.887369486030646 0.0310640781418789 -0.771604345564946 0.11079433849465 miRNATAP -0.361161084942719 1.14098507130986e-05 NA NA NA hsa-miR-188-5p FBN1 1.35426907033843 0.00038346077691455 -0.771604345564946 0.11079433849465 PITA -0.406183901098846 3.69402269801789e-06 NA NA NA hsa-miR-19b-1-5p FBN1 1.38738648038895 1.3113681938066e-06 -0.771604345564946 0.11079433849465 mirMAP -0.601166057266587 1.69769791384594e-07 NA NA NA hsa-miR-25-3p FBN1 1.00604871526544 0.000421838061147906 -0.771604345564946 0.11079433849465 mirMAP -0.492926454680129 3.28936071240098e-05 NA NA NA hsa-miR-3065-5p FBN1 -0.241623656423063 0.633116553078159 -0.771604345564946 0.11079433849465 mirMAP -0.279371080898396 5.25480953225034e-05 NA NA NA hsa-miR-32-3p FBN1 0.583525764322974 0.11837203008551 -0.771604345564946 0.11079433849465 miRNATAP -0.498735053185373 9.84736685206316e-07 NA NA NA hsa-miR-361-5p FBN1 0.407725414130987 0.0181260969156347 -0.771604345564946 0.11079433849465 mirMAP -0.701063540026209 0.000615413184150637 NA NA NA hsa-miR-375 FBN1 -2.94506033785642 0.00570147601654791 -0.771604345564946 0.11079433849465 mirMAP -0.115557338353387 0.000270435630940957 NA NA NA hsa-miR-429 FBN1 1.40182602301928 0.00900426780286475 -0.771604345564946 0.11079433849465 miRNATAP -0.376051122996118 8.56688264099012e-10 NA NA NA hsa-miR-486-5p FBN1 -0.627607241830911 0.155274583521138 -0.771604345564946 0.11079433849465 PITA;miRanda;miRNATAP -0.213855302148582 0.00614169334317185 27133060 miR 486 5p inhibits cell growth of papillary thyroid carcinoma by targeting fibrillin 1; Fibrillin-1 FBN1 was shown to be a direct target of miR-486-5p and inversely regulated by miR-486-5p; FBN1 silencing led to decreased PTC cell proliferation and enhanced apoptosis in vitro similar to that mediated by miR-486-5p; Furthermore miR-486-5p over-expression or FBN1 knock-down inhibited while up-regulation of FBN1 boosted xenograft tumor formation in vivo; Our data suggest that miR-486-5p induces PTC cell growth inhibition and apoptosis by targeting and suppressing FBN1 thyroid cancer hsa-miR-576-5p FBN1 0.625714137488957 0.0417100301848969 -0.771604345564946 0.11079433849465 mirMAP -0.490078258226726 9.85122676583648e-06 NA NA NA hsa-miR-577 FBN1 0.911619788986754 0.2256062124148 -0.771604345564946 0.11079433849465 mirMAP -0.201854672819317 1.20272250992681e-05 NA NA NA hsa-miR-582-5p FBN1 -0.448820171762719 0.134615974001015 -0.771604345564946 0.11079433849465 miRNATAP -0.366614772066901 0.0014738234358425 NA NA NA hsa-miR-590-3p FBN1 1.11654983899947 0.000160782154924864 -0.771604345564946 0.11079433849465 miRanda;mirMAP -0.539630283766565 1.91079250303213e-06 NA NA NA hsa-miR-92a-3p FBN1 1.2209325870225 6.8757197708107e-06 -0.771604345564946 0.11079433849465 mirMAP -0.770574868120666 1.35090622137033e-10 NA NA NA hsa-miR-375 FBN2 -2.94506033785642 0.00570147601654791 0.965070254239987 0.188197406826163 miRanda -0.277723544236514 2.826782293951e-09 NA NA NA hsa-miR-429 FBN2 1.40182602301928 0.00900426780286475 0.965070254239987 0.188197406826163 PITA;miRanda -0.257832509496244 0.00758505338429742 NA NA NA hsa-miR-625-3p FBN2 -0.185298294014366 0.626215541224408 0.965070254239987 0.188197406826163 MirTarget -0.380992284909274 0.0057122938924905 NA NA NA hsa-miR-103a-3p FERMT2 0.840525139266028 5.83536475789158e-07 -1.67553847722952 1.66731047547142e-05 MirTarget -0.857216682452953 2.00458434761165e-07 NA NA NA hsa-miR-107 FERMT2 0.904627575346218 4.67936495073904e-05 -1.67553847722952 1.66731047547142e-05 MirTarget;miRanda;miRNATAP -0.675967277675504 4.44031842969148e-08 NA NA NA hsa-miR-144-5p FERMT2 -0.644861505244731 0.173474442191587 -1.67553847722952 1.66731047547142e-05 MirTarget -0.168791543858213 0.00462842179288894 NA NA NA hsa-miR-15a-5p FERMT2 1.03783090449383 7.40334108980898e-07 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.674461281122568 2.35718909003109e-07 NA NA NA hsa-miR-15b-5p FERMT2 1.62046407540723 5.42152621571078e-09 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.63993169472316 9.16531061315488e-12 NA NA NA hsa-miR-16-5p FERMT2 1.00515772948091 5.33912942007619e-06 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.919918992128088 1.15312666864906e-14 NA NA NA hsa-miR-200b-3p FERMT2 0.974577911407732 0.0595020056914543 -1.67553847722952 1.66731047547142e-05 TargetScan -0.399086720396397 4.44358611127645e-15 24064224;26334393;23483548 miR 200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin 2; Quantitative mass spectrometry identified 57 putative miR-200b targets including Kindlin-2 previously implicated in the regulation of tumor invasiveness and actin cytoskeleton in other cell types; Enforced expression of miR-200b mimic in ESCC cells led to a decrease of Kindlin-2 expression whereas transfection of miR-200b inhibitor induced Kindlin-2 expression; Furthermore transfection of miR-200b mimic or knockdown of Kindlin-2 in ESCC cells decreased cell protrusion and focal adhesion FA formation reduced cell spreading and invasiveness/migration; Enforced expression of Kindlin-2 largely abrogated the inhibitory effects of miR-200b on ESCC cell invasiveness; The tumor suppressor effects of miR-200b may be due to its suppression of Kindlin-2 a novel target of miR-200b that modulates actin cytoskeleton FA formation and the migratory/invasiveness properties of ESCC;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness;Here we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation; Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family a mechanism that promotes breast cancer invasion ;; esophageal cancer;esophageal cancer;breast cancer hsa-miR-21-5p FERMT2 1.75445050487988 2.41825549682022e-23 -1.67553847722952 1.66731047547142e-05 miRNAWalker2_validate -0.422968227236367 0.00376565177926138 NA NA NA hsa-miR-221-3p FERMT2 1.33496247538338 3.82022531235275e-07 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.726200052310223 2.96056775324017e-13 NA NA NA hsa-miR-222-3p FERMT2 1.39382731585819 9.98182478024671e-07 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.641268499961146 3.95233700814315e-12 NA NA NA hsa-miR-29a-3p FERMT2 -0.113012156986374 0.615005009685815 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.394904250293198 0.00204059930570267 NA NA NA hsa-miR-29b-3p FERMT2 -0.230693226193598 0.367461626035234 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.304760812194871 0.00650510337623787 NA NA NA hsa-miR-32-3p FERMT2 0.583525764322974 0.11837203008551 -1.67553847722952 1.66731047547142e-05 MirTarget -0.397282076499062 2.09392276680111e-06 NA NA NA hsa-miR-320a FERMT2 0.593888711838028 0.011897419390526 -1.67553847722952 1.66731047547142e-05 miRanda -0.332682660477607 0.00592844602265615 NA NA NA hsa-miR-320b FERMT2 1.11183660885284 0.000497971211648503 -1.67553847722952 1.66731047547142e-05 miRanda -0.368423043635332 2.14520630559417e-05 NA NA NA hsa-miR-320c FERMT2 0.455072851945474 0.240613785444485 -1.67553847722952 1.66731047547142e-05 miRanda -0.268058995674287 0.00150293589719675 NA NA NA hsa-miR-3662 FERMT2 1.82780708047676 0.0054036501346178 -1.67553847722952 1.66731047547142e-05 MirTarget -0.20064930381304 0.000251640190778533 NA NA NA hsa-miR-424-5p FERMT2 1.08509868581983 0.000420473853818268 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.272227893855458 0.00280402693489907 NA NA NA hsa-miR-429 FERMT2 1.40182602301928 0.00900426780286475 -1.67553847722952 1.66731047547142e-05 miRanda;miRNATAP -0.405984180372683 4.08153588091193e-17 NA NA NA hsa-miR-582-5p FERMT2 -0.448820171762719 0.134615974001015 -1.67553847722952 1.66731047547142e-05 MirTarget;miRNATAP -0.272497306560403 0.00405002002205839 NA NA NA hsa-miR-590-3p FERMT2 1.11654983899947 0.000160782154924864 -1.67553847722952 1.66731047547142e-05 MirTarget;miRanda;mirMAP;miRNATAP -0.440850457333832 2.11857887870598e-06 NA NA NA hsa-miR-590-5p FERMT2 1.04171442093217 0.000272475544954865 -1.67553847722952 1.66731047547142e-05 miRanda -0.540661970388668 1.32566833211258e-08 NA NA NA hsa-miR-7-1-3p FERMT2 0.709309110750947 0.0412301737463194 -1.67553847722952 1.66731047547142e-05 mirMAP -0.403459192874618 3.9665459762728e-07 NA NA NA hsa-let-7a-3p FGF2 0.503048155002889 0.0411145454335299 -1.87861117290298 0.000125445679104344 mirMAP -0.410539117311516 0.00473622063740347 NA NA NA hsa-let-7b-3p FGF2 0.21838629112113 0.296038413622566 -1.87861117290298 0.000125445679104344 mirMAP -0.469514467711896 0.00680853109557966 NA NA NA hsa-let-7f-1-3p FGF2 1.28704406797397 1.17954701106157e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.595048658334427 4.14210020217409e-06 NA NA NA hsa-miR-103a-3p FGF2 0.840525139266028 5.83536475789158e-07 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.939824662070765 6.5144907085955e-06 NA NA NA hsa-miR-107 FGF2 0.904627575346218 4.67936495073904e-05 -1.87861117290298 0.000125445679104344 MirTarget;PITA;miRanda;miRNATAP -0.633691610533513 5.77496353910729e-05 NA NA NA hsa-miR-15a-5p FGF2 1.03783090449383 7.40334108980898e-07 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.723624902429406 1.17476403328068e-05 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 1.75738933306437 3.00554466232543e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.601578664515957 9.71241978321172e-09 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 1.62046407540723 5.42152621571078e-09 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.727556694335382 9.63850854162267e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 1.43227522002564 3.70920454953168e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.533569195692814 4.82742810832383e-05 NA NA NA hsa-miR-16-2-3p FGF2 1.8048179609245 2.83095715136409e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.582691850054445 1.0626071080659e-07 NA NA NA hsa-miR-16-5p FGF2 1.00515772948091 5.33912942007619e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;MirTarget;miRNATAP -0.87728356493459 1.36815119437221e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 0.149964130725901 0.434709542998771 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate;mirMAP -0.536525732490695 0.00470973709226905 NA NA NA hsa-miR-192-5p FGF2 0.0809146624034405 0.941057093528709 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.100431705795905 0.00182203175890127 NA NA NA hsa-miR-19b-1-5p FGF2 1.38738648038895 1.3113681938066e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.540056441979374 5.90790389026898e-06 NA NA NA hsa-miR-200b-3p FGF2 0.974577911407732 0.0595020056914543 -1.87861117290298 0.000125445679104344 mirMAP -0.35358155461024 1.0502797949384e-07 NA NA NA hsa-miR-200c-3p FGF2 1.28185685499076 0.00369777635539177 -1.87861117290298 0.000125445679104344 mirMAP -0.459255722541169 2.21550497680624e-09 NA NA NA hsa-miR-20a-3p FGF2 1.13957127410163 0.000451087640268489 -1.87861117290298 0.000125445679104344 mirMAP -0.635980126804227 1.03782626210616e-09 NA NA NA hsa-miR-21-3p FGF2 1.75245546017565 2.36505176715025e-10 -1.87861117290298 0.000125445679104344 mirMAP -0.541952936598777 7.7895313994942e-06 NA NA NA hsa-miR-21-5p FGF2 1.75445050487988 2.41825549682022e-23 -1.87861117290298 0.000125445679104344 mirMAP -0.484524479326667 0.00821705219155879 NA NA NA hsa-miR-215-5p FGF2 0.715250240418615 0.573784317311889 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.104771518281948 0.000141751804794456 NA NA NA hsa-miR-221-3p FGF2 1.33496247538338 3.82022531235275e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.544428779797939 3.02629502512127e-05 NA NA NA hsa-miR-222-3p FGF2 1.39382731585819 9.98182478024671e-07 -1.87861117290298 0.000125445679104344 mirMAP -0.541204112402845 6.44319127167856e-06 NA NA NA hsa-miR-29a-5p FGF2 0.585084040404152 0.023014129158495 -1.87861117290298 0.000125445679104344 mirMAP -0.424035558508381 0.00219032018724374 NA NA NA hsa-miR-330-3p FGF2 0.798460296022179 0.00746538156533435 -1.87861117290298 0.000125445679104344 mirMAP -0.498128953238189 2.14033471411407e-05 NA NA NA hsa-miR-335-3p FGF2 2.5197689063267 2.20084506976733e-09 -1.87861117290298 0.000125445679104344 mirMAP -0.417269866841731 1.09046144483422e-07 NA NA NA hsa-miR-335-5p FGF2 1.59953351087307 5.56170899867314e-05 -1.87861117290298 0.000125445679104344 miRNATAP -0.323054850441658 0.000208841445593432 NA NA NA hsa-miR-3662 FGF2 1.82780708047676 0.0054036501346178 -1.87861117290298 0.000125445679104344 mirMAP -0.212606715986015 0.00207695589115596 NA NA NA hsa-miR-3682-3p FGF2 1.96838261925327 4.94885331227292e-06 -1.87861117290298 0.000125445679104344 mirMAP -0.621299624827262 8.40451860827003e-12 NA NA NA hsa-miR-424-5p FGF2 1.08509868581983 0.000420473853818268 -1.87861117290298 0.000125445679104344 MirTarget;miRNATAP -0.473116310929624 2.79114365346124e-05 NA NA NA hsa-miR-429 FGF2 1.40182602301928 0.00900426780286475 -1.87861117290298 0.000125445679104344 mirMAP -0.389653476745427 6.14878920514716e-10 NA NA NA hsa-miR-503-5p FGF2 1.88558728489534 2.26317868368257e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.328905971783003 0.000129296346907329 NA NA NA hsa-miR-577 FGF2 0.911619788986754 0.2256062124148 -1.87861117290298 0.000125445679104344 mirMAP -0.189066289658318 7.18727306857422e-05 NA NA NA hsa-miR-589-3p FGF2 1.01962606923682 0.00577853347252709 -1.87861117290298 0.000125445679104344 mirMAP -0.306084948128741 0.00129523811230291 NA NA NA hsa-miR-590-3p FGF2 1.11654983899947 0.000160782154924864 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.502156114781839 1.81367444334514e-05 NA NA NA hsa-miR-590-5p FGF2 1.04171442093217 0.000272475544954865 -1.87861117290298 0.000125445679104344 miRanda;mirMAP -0.698076507895779 4.36148419548274e-09 NA NA NA hsa-miR-92a-3p FGF2 1.2209325870225 6.8757197708107e-06 -1.87861117290298 0.000125445679104344 miRNAWalker2_validate -0.711959382156384 1.14570619492506e-08 NA NA NA hsa-miR-93-3p FGF2 1.88964231421793 1.80075645722786e-08 -1.87861117290298 0.000125445679104344 mirMAP -0.494286067593777 7.56548629194091e-07 NA NA NA hsa-miR-16-5p FLNA 1.00515772948091 5.33912942007619e-06 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.827881738848939 6.9612528228536e-10 NA NA NA hsa-miR-196a-5p FLNA 6.59255881689547 1.53691144193899e-22 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.274091746125286 1.45025007579472e-12 NA NA NA hsa-miR-200c-3p FLNA 1.28185685499076 0.00369777635539177 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.503986999594505 1.09905371484172e-14 NA NA NA hsa-miR-20a-5p FLNA 1.4503375861709 5.7813456424762e-07 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.568786552642642 2.07249264495414e-08 NA NA NA hsa-miR-221-3p FLNA 1.33496247538338 3.82022531235275e-07 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.488659710562545 1.83895206875089e-05 24443580 In addition the oPD thyroid carcinomas demonstrated upregulation of miR-221 and miR-885-5p thyroid cancer hsa-miR-222-3p FLNA 1.39382731585819 9.98182478024671e-07 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.544619034600024 1.65671740753115e-07 NA NA NA hsa-miR-378a-3p FLNA -0.192828831363649 0.530795182107493 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.317868545532846 0.00171515137030305 NA NA NA hsa-miR-484 FLNA 0.71327898984355 0.00233605130771196 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.367129261982306 0.00582823380053421 NA NA NA hsa-miR-615-3p FLNA 2.82967143704683 3.05118423223543e-05 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.257708487956948 2.69182970182006e-05 NA NA NA hsa-miR-7-5p FLNA 1.63575693499363 0.0124424214624534 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.340682406730971 2.31982324720373e-13 NA NA NA hsa-miR-92a-3p FLNA 1.2209325870225 6.8757197708107e-06 -1.06210803487235 0.014306669788314 miRNAWalker2_validate -0.576553861971345 1.53706453251178e-07 NA NA NA hsa-miR-185-3p FMOD 1.33711019171256 3.45756583967985e-05 -1.99039817416605 7.59983780161703e-06 MirTarget -0.376963241363942 0.000118909733218228 NA NA NA hsa-miR-330-5p FMOD 0.488365986827708 0.0512207630808233 -1.99039817416605 7.59983780161703e-06 miRanda -0.356641481188164 0.00634159155054864 NA NA NA hsa-miR-590-5p FMOD 1.04171442093217 0.000272475544954865 -1.99039817416605 7.59983780161703e-06 miRanda -0.532804629435432 1.33248613209368e-06 NA NA NA hsa-miR-139-5p FN1 -1.83374360776637 1.22019901002824e-09 0.118836029927559 0.829908309383186 miRanda -0.51636898560642 3.04507510907817e-05 NA NA NA hsa-miR-144-3p FN1 -0.13309578176575 0.798245647923351 0.118836029927559 0.829908309383186 MirTarget -0.252389637466052 0.000897770062121993 NA NA NA hsa-miR-16-1-3p FN1 1.43227522002564 3.70920454953168e-08 0.118836029927559 0.829908309383186 mirMAP -0.545258732831528 0.000188816652957985 NA NA NA hsa-miR-200b-3p FN1 0.974577911407732 0.0595020056914543 0.118836029927559 0.829908309383186 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.500583267105701 3.26699028080128e-12 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 1.28185685499076 0.00369777635539177 0.118836029927559 0.829908309383186 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.52568201780896 5.80464696284483e-10 NA NA NA hsa-miR-26b-5p FN1 -0.301646326928219 0.160081421968103 0.118836029927559 0.829908309383186 miRNAWalker2_validate -0.754075084753485 4.35846957381142e-05 NA NA NA hsa-miR-27a-5p FN1 1.09051796355562 0.00189340505433517 0.118836029927559 0.829908309383186 MirTarget -0.358871489517563 0.00119929858485285 NA NA NA hsa-miR-320a FN1 0.593888711838028 0.011897419390526 0.118836029927559 0.829908309383186 miRanda -0.514896418842924 0.00212462852007981 NA NA NA hsa-miR-320b FN1 1.11183660885284 0.000497971211648503 0.118836029927559 0.829908309383186 miRanda -0.432255699600111 0.000366424407111178 NA NA NA hsa-miR-320c FN1 0.455072851945474 0.240613785444485 0.118836029927559 0.829908309383186 miRanda -0.34947516775191 0.00294649198012234 NA NA NA hsa-miR-33a-3p FN1 0.347011402017138 0.321709379745392 0.118836029927559 0.829908309383186 mirMAP -0.50597307902061 1.52742404669564e-05 NA NA NA hsa-miR-429 FN1 1.40182602301928 0.00900426780286475 0.118836029927559 0.829908309383186 MirTarget;PITA;miRanda;miRNATAP -0.467072109634058 1.47471377104424e-11 NA NA NA hsa-miR-590-3p FN1 1.11654983899947 0.000160782154924864 0.118836029927559 0.829908309383186 miRanda;mirMAP -0.425521200588534 0.00118012490517232 NA NA NA hsa-miR-615-3p FN1 2.82967143704683 3.05118423223543e-05 0.118836029927559 0.829908309383186 miRNAWalker2_validate -0.222586148788799 0.00469866439311566 NA NA NA hsa-miR-96-5p FN1 1.14243043653372 0.00942969392739105 0.118836029927559 0.829908309383186 MirTarget;TargetScan -0.242716173186797 0.00922070975605794 NA NA NA hsa-let-7a-3p FSTL1 0.503048155002889 0.0411145454335299 -0.228140018059121 0.509233804365528 mirMAP -0.287823666674878 0.00420556484144506 NA NA NA hsa-miR-142-5p FSTL1 1.55592486377018 6.69269968016779e-06 -0.228140018059121 0.509233804365528 PITA;mirMAP -0.184463971101385 0.00808869616978743 NA NA NA hsa-miR-148a-5p FSTL1 -0.69329616490858 0.0793012233740369 -0.228140018059121 0.509233804365528 mirMAP -0.239769993776464 9.5903294192982e-05 NA NA NA hsa-miR-18a-3p FSTL1 2.35188582849667 1.39401350286321e-08 -0.228140018059121 0.509233804365528 MirTarget -0.169171257063432 0.00302224414224831 NA NA NA hsa-miR-200b-3p FSTL1 0.974577911407732 0.0595020056914543 -0.228140018059121 0.509233804365528 MirTarget;TargetScan -0.311628816865563 3.79174641648213e-12 NA NA NA hsa-miR-200c-3p FSTL1 1.28185685499076 0.00369777635539177 -0.228140018059121 0.509233804365528 MirTarget -0.398574862896293 1.08910000599394e-14 NA NA NA hsa-miR-203a-3p FSTL1 1.44736908507496 0.0394116388736904 -0.228140018059121 0.509233804365528 MirTarget -0.197969634733288 3.37228150723949e-09 NA NA NA hsa-miR-20a-3p FSTL1 1.13957127410163 0.000451087640268489 -0.228140018059121 0.509233804365528 mirMAP -0.291569268860643 8.37849899995526e-05 NA NA NA hsa-miR-26b-5p FSTL1 -0.301646326928219 0.160081421968103 -0.228140018059121 0.509233804365528 miRNAWalker2_validate -0.432846296797325 0.000179574124805843 NA NA NA hsa-miR-27b-5p FSTL1 0.680479953627235 0.0149700717026754 -0.228140018059121 0.509233804365528 mirMAP -0.284173250548493 0.00119478138745259 NA NA NA hsa-miR-29a-5p FSTL1 0.585084040404152 0.023014129158495 -0.228140018059121 0.509233804365528 mirMAP -0.259711209453498 0.00685377068567729 NA NA NA hsa-miR-320b FSTL1 1.11183660885284 0.000497971211648503 -0.228140018059121 0.509233804365528 miRanda -0.209470868293724 0.0059949483783235 NA NA NA hsa-miR-330-3p FSTL1 0.798460296022179 0.00746538156533435 -0.228140018059121 0.509233804365528 mirMAP -0.266479497807883 0.00113813124241194 NA NA NA hsa-miR-335-3p FSTL1 2.5197689063267 2.20084506976733e-09 -0.228140018059121 0.509233804365528 mirMAP -0.19194882513078 0.000544205971691399 NA NA NA hsa-miR-3662 FSTL1 1.82780708047676 0.0054036501346178 -0.228140018059121 0.509233804365528 mirMAP -0.127673535885317 0.00772807134776622 NA NA NA hsa-miR-429 FSTL1 1.40182602301928 0.00900426780286475 -0.228140018059121 0.509233804365528 MirTarget;PITA;miRanda -0.307157567694259 7.89448742819223e-13 NA NA NA hsa-miR-576-5p FSTL1 0.625714137488957 0.0417100301848969 -0.228140018059121 0.509233804365528 mirMAP -0.259535857811473 0.0011440609352561 NA NA NA hsa-miR-590-3p FSTL1 1.11654983899947 0.000160782154924864 -0.228140018059121 0.509233804365528 miRanda;mirMAP -0.27143244807912 0.000910349309376293 NA NA NA hsa-miR-615-3p FSTL1 2.82967143704683 3.05118423223543e-05 -0.228140018059121 0.509233804365528 miRNAWalker2_validate -0.170981133279549 0.000468543114816479 NA NA NA hsa-miR-616-5p FSTL1 0.834052908652744 0.0347835664029363 -0.228140018059121 0.509233804365528 mirMAP -0.173184261519179 0.0061147214719322 NA NA NA hsa-miR-7-1-3p FSTL1 0.709309110750947 0.0412301737463194 -0.228140018059121 0.509233804365528 MirTarget -0.252451513692127 0.000319700693536193 NA NA NA hsa-miR-20a-3p FSTL3 1.13957127410163 0.000451087640268489 0.0201968093929938 0.964564655833573 mirMAP -0.318050261344562 0.00119632327011752 NA NA NA hsa-miR-375 FSTL3 -2.94506033785642 0.00570147601654791 0.0201968093929938 0.964564655833573 miRNAWalker2_validate -0.166484661556345 9.08507176604595e-09 NA NA NA hsa-miR-324-5p FZD8 1.08820215809537 3.11674414561836e-05 -1.68511420434562 6.09052149182579e-05 miRanda -0.335790881363403 0.00361619739529918 NA NA NA hsa-miR-335-5p FZD8 1.59953351087307 5.56170899867314e-05 -1.68511420434562 6.09052149182579e-05 miRNAWalker2_validate -0.246449216460617 0.00103891160966273 NA NA NA hsa-miR-590-3p FZD8 1.11654983899947 0.000160782154924864 -1.68511420434562 6.09052149182579e-05 miRanda -0.312768041823135 0.00212552048468477 NA NA NA hsa-miR-148b-3p GADD45A 0.295175884456199 0.17466422420702 -0.744381186012481 0.00247182040910746 MirTarget -0.214957101032821 0.00927854827400905 NA NA NA hsa-miR-454-3p GADD45A 0.625199142970745 0.0134890997402741 -0.744381186012481 0.00247182040910746 MirTarget;miRNATAP -0.217978566953222 0.00180852644098547 NA NA NA hsa-miR-1976 GADD45B 0.923172654386147 0.000118514313506673 -1.91754262778042 5.17429057228523e-08 miRNATAP -0.58594227558951 2.17579979542256e-08 NA NA NA hsa-miR-324-3p GADD45B 1.04940352369965 0.000387716796520961 -1.91754262778042 5.17429057228523e-08 MirTarget;miRNATAP -0.3687003729794 1.78715342431653e-05 NA NA NA hsa-miR-590-3p GADD45B 1.11654983899947 0.000160782154924864 -1.91754262778042 5.17429057228523e-08 miRanda -0.368023929046783 1.76170990966765e-05 NA NA NA hsa-miR-130b-3p GAS1 1.32714007211004 4.78676252285191e-05 -0.809021067362787 0.210049456190503 miRNAWalker2_validate -0.489287863871912 0.000389874633205937 NA NA NA hsa-miR-148a-3p GAS1 -1.53721533763578 3.55533747293117e-05 -0.809021067362787 0.210049456190503 miRNAWalker2_validate -0.517082906618391 1.58636916519721e-05 NA NA NA hsa-miR-186-5p GAS1 0.149964130725901 0.434709542998771 -0.809021067362787 0.210049456190503 mirMAP -0.697837424797157 0.00457258541265146 NA NA NA hsa-miR-26b-3p GAS1 -0.0103961389461977 0.965770899625511 -0.809021067362787 0.210049456190503 MirTarget -0.675066591544492 0.000428264188601704 NA NA NA hsa-miR-32-3p GAS1 0.583525764322974 0.11837203008551 -0.809021067362787 0.210049456190503 mirMAP -0.487910503429813 0.000399887780458344 NA NA NA hsa-miR-34a-5p GAS1 0.794251341270032 0.00024017386701179 -0.809021067362787 0.210049456190503 miRNAWalker2_validate;miRNATAP -0.916765422136074 1.29782261551642e-05 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-625-5p GAS1 0.537211086526376 0.203801009380384 -0.809021067362787 0.210049456190503 MirTarget -0.75444219051627 2.69069624181616e-13 NA NA NA hsa-miR-141-3p GEM 1.45548825076434 0.00115958850961764 -0.864985805491278 0.035766843258006 MirTarget -0.351571293348651 2.36397787666961e-08 NA NA NA hsa-miR-200a-3p GEM 0.717826667295984 0.193912116506827 -0.864985805491278 0.035766843258006 MirTarget -0.139432289120655 0.00871916044424156 NA NA NA hsa-miR-200b-3p GEM 0.974577911407732 0.0595020056914543 -0.864985805491278 0.035766843258006 MirTarget -0.192659044907615 0.000627770093650666 NA NA NA hsa-miR-200c-3p GEM 1.28185685499076 0.00369777635539177 -0.864985805491278 0.035766843258006 MirTarget;miRNATAP -0.361474999634682 1.63691557434976e-08 NA NA NA hsa-miR-224-3p GEM 1.52422171450716 0.00650463542340912 -0.864985805491278 0.035766843258006 MirTarget -0.279774672921221 5.26957778449383e-07 NA NA NA hsa-miR-26b-5p GEM -0.301646326928219 0.160081421968103 -0.864985805491278 0.035766843258006 miRNAWalker2_validate -0.365657440980428 0.0089156991422452 NA NA NA hsa-miR-335-5p GEM 1.59953351087307 5.56170899867314e-05 -0.864985805491278 0.035766843258006 miRNAWalker2_validate -0.229936851226573 0.00154573025406494 NA NA NA hsa-miR-429 GEM 1.40182602301928 0.00900426780286475 -0.864985805491278 0.035766843258006 MirTarget;PITA;miRanda;miRNATAP -0.222347432434834 3.43251732407575e-05 NA NA NA hsa-miR-590-3p GEM 1.11654983899947 0.000160782154924864 -0.864985805491278 0.035766843258006 miRanda -0.342268020744261 0.000475888991808625 NA NA NA hsa-miR-101-3p GJA1 -0.451263906815861 0.0283387250173031 0.397281797124359 0.492499261466701 MirTarget;miRNATAP -0.839711317839674 2.95601915606307e-05 NA NA NA hsa-miR-148a-5p GJA1 -0.69329616490858 0.0793012233740369 0.397281797124359 0.492499261466701 MirTarget;miRNATAP -0.634287812818781 2.14302116119903e-10 NA NA NA hsa-miR-148b-5p GJA1 1.04409494910362 0.00195860954157389 0.397281797124359 0.492499261466701 MirTarget -0.437246609583432 0.000283707025357041 NA NA NA hsa-miR-17-5p GJA1 1.65862087862483 8.45603406215941e-08 0.397281797124359 0.492499261466701 TargetScan -0.385563461432926 0.00279627560083497 NA NA NA hsa-miR-186-5p GJA1 0.149964130725901 0.434709542998771 0.397281797124359 0.492499261466701 MirTarget;miRNATAP -1.02076707925486 2.38415921647783e-06 NA NA NA hsa-miR-19a-3p GJA1 1.26669687448473 0.000105972838514412 0.397281797124359 0.492499261466701 MirTarget;miRNATAP -0.419335301510116 0.000705884244566645 NA NA NA hsa-miR-19b-3p GJA1 0.759818275708988 0.00652779573186786 0.397281797124359 0.492499261466701 MirTarget;miRNATAP -0.486765938035006 0.000923027909710243 NA NA NA hsa-miR-217 GJA1 -0.0121404731225336 0.980818372851502 0.397281797124359 0.492499261466701 miRanda -0.30183403739811 0.000190465134449028 NA NA NA hsa-miR-30b-5p GJA1 -0.430720743745757 0.0593564057320791 0.397281797124359 0.492499261466701 MirTarget;mirMAP -1.01976270718837 8.13420197956455e-09 NA NA NA hsa-miR-30c-5p GJA1 -0.983130268805942 4.60419218706127e-05 0.397281797124359 0.492499261466701 MirTarget;mirMAP;miRNATAP -0.468161029849716 0.00580045924769438 NA NA NA hsa-miR-30d-3p GJA1 -0.545113326540761 0.0433733076874155 0.397281797124359 0.492499261466701 MirTarget -0.862501134408864 6.40340653634198e-09 NA NA NA hsa-miR-30d-5p GJA1 -0.5492586056147 0.0140125082460125 0.397281797124359 0.492499261466701 MirTarget;mirMAP;miRNATAP -1.08207083844339 1.70358735055556e-09 NA NA NA hsa-miR-429 GJA1 1.40182602301928 0.00900426780286475 0.397281797124359 0.492499261466701 miRanda;miRNATAP -0.442239916530099 1.59152078504856e-09 NA NA NA hsa-miR-616-5p GJA1 0.834052908652744 0.0347835664029363 0.397281797124359 0.492499261466701 MirTarget;mirMAP -0.284914204930934 0.00719258470815737 NA NA NA hsa-miR-7-1-3p GJA1 0.709309110750947 0.0412301737463194 0.397281797124359 0.492499261466701 mirMAP -0.97776065790807 1.35477694133426e-19 NA NA NA hsa-miR-107 GLIPR1 0.904627575346218 4.67936495073904e-05 0.275013178371114 0.434503105718563 miRanda -0.56177944498721 2.97972196478446e-07 NA NA NA hsa-miR-148b-5p GLIPR1 1.04409494910362 0.00195860954157389 0.275013178371114 0.434503105718563 mirMAP -0.196776632380808 0.00759144354623552 NA NA NA hsa-miR-20a-3p GLIPR1 1.13957127410163 0.000451087640268489 0.275013178371114 0.434503105718563 mirMAP -0.236500594124392 0.00187401381839735 NA NA NA hsa-miR-26b-3p GLIPR1 -0.0103961389461977 0.965770899625511 0.275013178371114 0.434503105718563 mirMAP -0.475762960154554 3.86223989009079e-06 NA NA NA hsa-miR-30d-3p GLIPR1 -0.545113326540761 0.0433733076874155 0.275013178371114 0.434503105718563 mirMAP -0.364101345949519 7.98364390850961e-05 NA NA NA hsa-miR-335-3p GLIPR1 2.5197689063267 2.20084506976733e-09 0.275013178371114 0.434503105718563 mirMAP -0.208017287967598 0.000226447512679005 NA NA NA hsa-miR-338-3p GLIPR1 -0.959276231066179 0.0191473351014091 0.275013178371114 0.434503105718563 PITA;miRanda -0.203141296787172 0.000783931206339009 NA NA NA hsa-miR-877-5p GLIPR1 2.17859965442336 1.03593450648516e-07 0.275013178371114 0.434503105718563 MirTarget -0.170379911298152 0.0038725439026134 NA NA NA hsa-miR-942-5p GLIPR1 1.90585138008274 3.11903311044863e-09 0.275013178371114 0.434503105718563 MirTarget -0.2150376521932 0.00402794916224554 NA NA NA hsa-miR-194-3p GPC1 0.259420201261466 0.821811295418686 1.04573026970482 0.0644516018669038 mirMAP -0.36123720469045 9.38780979438058e-34 NA NA NA hsa-miR-326 GPC1 -0.429748586406214 0.2629894124021 1.04573026970482 0.0644516018669038 mirMAP -0.644026021540133 3.04980564956575e-10 NA NA NA hsa-miR-361-3p GPC1 -0.126462931388735 0.566052688733137 1.04573026970482 0.0644516018669038 mirMAP -0.911814767164458 6.11610734495107e-07 NA NA NA hsa-miR-29a-3p GPX7 -0.113012156986374 0.615005009685815 0.575903469408382 0.17572053357825 MirTarget;miRNATAP -0.438404518701126 0.00136128523539407 NA NA NA hsa-miR-29b-3p GPX7 -0.230693226193598 0.367461626035234 0.575903469408382 0.17572053357825 MirTarget;miRNATAP -0.330974394428313 0.0057376090395896 NA NA NA hsa-miR-429 GPX7 1.40182602301928 0.00900426780286475 0.575903469408382 0.17572053357825 miRNATAP -0.276382657306016 4.23635169664796e-07 NA NA NA hsa-let-7f-1-3p GREM1 1.28704406797397 1.17954701106157e-06 -0.69985982002181 0.312482771592333 mirMAP -0.509816302200564 0.00530993899874079 NA NA NA hsa-miR-107 GREM1 0.904627575346218 4.67936495073904e-05 -0.69985982002181 0.312482771592333 miRanda -1.36913763822901 1.10332009894017e-10 NA NA NA hsa-miR-10b-3p GREM1 0.773619331000039 0.0076628900286607 -0.69985982002181 0.312482771592333 MirTarget -0.609800101839851 0.000306792346148886 NA NA NA hsa-miR-128-3p GREM1 0.98280381420517 5.77641850797209e-05 -0.69985982002181 0.312482771592333 MirTarget -1.25203451835573 7.06727189620737e-11 NA NA NA hsa-miR-142-5p GREM1 1.55592486377018 6.69269968016779e-06 -0.69985982002181 0.312482771592333 mirMAP -0.416797449702124 0.00284105845904977 NA NA NA hsa-miR-151a-3p GREM1 1.00322719901751 7.20903658270795e-06 -0.69985982002181 0.312482771592333 MirTarget -1.23496468390422 5.61321687122535e-09 NA NA NA hsa-miR-15b-3p GREM1 1.75738933306437 3.00554466232543e-08 -0.69985982002181 0.312482771592333 mirMAP -0.906945502081636 3.67924552313513e-10 NA NA NA hsa-miR-181b-5p GREM1 1.64216500592669 1.89228845300725e-08 -0.69985982002181 0.312482771592333 MirTarget -0.441403455901714 0.00704103469933012 NA NA NA hsa-miR-186-5p GREM1 0.149964130725901 0.434709542998771 -0.69985982002181 0.312482771592333 mirMAP -1.39409369383875 5.74369235427736e-08 NA NA NA hsa-miR-200b-3p GREM1 0.974577911407732 0.0595020056914543 -0.69985982002181 0.312482771592333 MirTarget -0.584274194879418 1.34679324468495e-10 NA NA NA hsa-miR-200c-3p GREM1 1.28185685499076 0.00369777635539177 -0.69985982002181 0.312482771592333 MirTarget -0.691759540305936 6.41614070458428e-11 NA NA NA hsa-miR-222-5p GREM1 1.87968474330782 1.11743009485711e-06 -0.69985982002181 0.312482771592333 MirTarget -0.794424110067097 2.19578246096464e-11 NA NA NA hsa-miR-29a-5p GREM1 0.585084040404152 0.023014129158495 -0.69985982002181 0.312482771592333 mirMAP -0.746149949889014 9.44158729989718e-05 NA NA NA hsa-miR-30d-3p GREM1 -0.545113326540761 0.0433733076874155 -0.69985982002181 0.312482771592333 MirTarget -0.986010270695943 3.46215364048784e-08 NA NA NA hsa-miR-32-3p GREM1 0.583525764322974 0.11837203008551 -0.69985982002181 0.312482771592333 mirMAP -0.621804031156199 2.29190888283785e-05 NA NA NA hsa-miR-330-3p GREM1 0.798460296022179 0.00746538156533435 -0.69985982002181 0.312482771592333 mirMAP -0.737258143881964 5.71360729835157e-06 NA NA NA hsa-miR-3614-5p GREM1 1.10426689932954 0.00706308396674599 -0.69985982002181 0.312482771592333 MirTarget -0.586079982581871 7.73922806853519e-07 NA NA NA hsa-miR-362-3p GREM1 -0.0349414695893027 0.913780708043777 -0.69985982002181 0.312482771592333 miRanda -0.612394466795312 6.04870257426355e-05 NA NA NA hsa-miR-3662 GREM1 1.82780708047676 0.0054036501346178 -0.69985982002181 0.312482771592333 mirMAP -0.371100811037312 9.93446955997418e-05 NA NA NA hsa-miR-429 GREM1 1.40182602301928 0.00900426780286475 -0.69985982002181 0.312482771592333 MirTarget;miRanda -0.578350549057547 2.90302494653021e-11 NA NA NA hsa-miR-484 GREM1 0.71327898984355 0.00233605130771196 -0.69985982002181 0.312482771592333 PITA -0.805657310581097 0.00012187877072676 NA NA NA hsa-miR-576-5p GREM1 0.625714137488957 0.0417100301848969 -0.69985982002181 0.312482771592333 mirMAP -0.804343110918702 3.12104047022431e-07 NA NA NA hsa-miR-577 GREM1 0.911619788986754 0.2256062124148 -0.69985982002181 0.312482771592333 mirMAP -0.435813923615764 7.76602615094255e-12 NA NA NA hsa-miR-616-5p GREM1 0.834052908652744 0.0347835664029363 -0.69985982002181 0.312482771592333 mirMAP -0.606269274548629 1.08556053568317e-06 NA NA NA hsa-miR-642a-5p GREM1 -0.626411225079539 0.175275421929086 -0.69985982002181 0.312482771592333 MirTarget -0.486726139056774 1.41414500358217e-05 NA NA NA hsa-miR-16-5p HTRA1 1.00515772948091 5.33912942007619e-06 0.39638289706457 0.222638541867684 miRNAWalker2_validate -0.37786676949595 0.000247048044028673 NA NA NA hsa-miR-26b-5p HTRA1 -0.301646326928219 0.160081421968103 0.39638289706457 0.222638541867684 miRNAWalker2_validate -0.36042765840373 0.000964902729815862 NA NA NA hsa-miR-628-5p HTRA1 -0.535322919688788 0.0377881249470294 0.39638289706457 0.222638541867684 miRNATAP -0.245078881766877 0.00669910853050755 NA NA NA hsa-miR-27a-3p ID2 1.29886998470345 2.68986118553486e-08 -0.123138990002922 0.714724898249103 MirTarget;miRNATAP -0.522251676846649 8.1966660483647e-08 NA NA NA hsa-miR-27b-3p ID2 0.0836323965901755 0.725273923274 -0.123138990002922 0.714724898249103 MirTarget;miRNATAP -0.29078729587596 0.00439025834737395 NA NA NA hsa-miR-455-3p ID2 2.29532323519288 1.85675588946527e-07 -0.123138990002922 0.714724898249103 MirTarget;PITA;miRNATAP -0.157912726636148 0.00260885316985629 NA NA NA hsa-miR-330-5p IGFBP4 0.488365986827708 0.0512207630808233 -0.41031491609756 0.20028591111239 MirTarget;miRanda -0.300979536736373 0.000994044136342115 NA NA NA hsa-miR-532-3p IGFBP4 0.552364451472481 0.0975490365586023 -0.41031491609756 0.20028591111239 miRNATAP -0.219613703751813 0.001293812208723 NA NA NA hsa-miR-129-5p IL15 -2.56914016541176 2.36237896095709e-06 0.561205086043478 0.114361741556834 miRanda -0.129626089860845 0.00483201901929051 NA NA NA hsa-miR-429 IL15 1.40182602301928 0.00900426780286475 0.561205086043478 0.114361741556834 miRanda -0.128722570816782 0.0058829595323254 NA NA NA hsa-miR-335-5p IL6 1.59953351087307 5.56170899867314e-05 -0.231605470294641 0.731469898867652 miRNAWalker2_validate -0.506635073744166 1.52521264215909e-05 NA NA NA hsa-miR-429 IL6 1.40182602301928 0.00900426780286475 -0.231605470294641 0.731469898867652 miRanda -0.444331362467888 2.80787806769216e-07 NA NA NA hsa-miR-126-5p INHBA 0.41765430251855 0.0753161203651532 3.10074554256306 4.5910988898154e-07 mirMAP -0.852254535255397 8.86065275907128e-06 NA NA NA hsa-miR-129-5p INHBA -2.56914016541176 2.36237896095709e-06 3.10074554256306 4.5910988898154e-07 miRanda -0.221319360989417 0.00704634188375972 NA NA NA hsa-miR-148b-3p INHBA 0.295175884456199 0.17466422420702 3.10074554256306 4.5910988898154e-07 miRNAWalker2_validate -0.80477233853279 0.000123181449721981 NA NA NA hsa-miR-195-3p INHBA -1.34779269408059 2.01619826639376e-05 3.10074554256306 4.5910988898154e-07 mirMAP -0.366071717925326 0.00966645900846285 NA NA NA hsa-miR-200b-3p INHBA 0.974577911407732 0.0595020056914543 3.10074554256306 4.5910988898154e-07 TargetScan -0.350984545403517 4.39220412828961e-05 NA NA NA hsa-miR-26a-5p INHBA -0.384110714440647 0.0442498636014044 3.10074554256306 4.5910988898154e-07 mirMAP -1.0052141699742 2.59051956122458e-05 NA NA NA hsa-miR-26b-5p INHBA -0.301646326928219 0.160081421968103 3.10074554256306 4.5910988898154e-07 mirMAP -0.917685251574321 1.39837197421751e-05 NA NA NA hsa-miR-30a-5p INHBA -1.71922855140016 3.20574349285256e-07 3.10074554256306 4.5910988898154e-07 mirMAP -0.466262705304313 0.000325227247052396 NA NA NA hsa-miR-30b-5p INHBA -0.430720743745757 0.0593564057320791 3.10074554256306 4.5910988898154e-07 mirMAP -1.03563349514223 1.12835065354727e-07 NA NA NA hsa-miR-30c-5p INHBA -0.983130268805942 4.60419218706127e-05 3.10074554256306 4.5910988898154e-07 mirMAP -0.708311676477352 0.000122464286950274 NA NA NA hsa-miR-30d-5p INHBA -0.5492586056147 0.0140125082460125 3.10074554256306 4.5910988898154e-07 mirMAP -1.27679558136839 6.43240370301801e-11 NA NA NA hsa-miR-30e-5p INHBA -0.573784818166736 0.0112497802572927 3.10074554256306 4.5910988898154e-07 mirMAP -0.951160708488015 1.48247944326767e-06 NA NA NA hsa-miR-577 INHBA 0.911619788986754 0.2256062124148 3.10074554256306 4.5910988898154e-07 mirMAP -0.299435133801904 5.81100093041283e-07 NA NA NA hsa-miR-664a-3p INHBA -0.83041219170254 0.000136267547251167 3.10074554256306 4.5910988898154e-07 mirMAP -0.867874992244643 2.31111864254784e-05 NA NA NA hsa-miR-139-5p ITGA2 -1.83374360776637 1.22019901002824e-09 1.82303263479838 1.19675255377204e-07 PITA;miRanda -0.309707147623095 0.000108371369022976 NA NA NA hsa-miR-186-5p ITGA2 0.149964130725901 0.434709542998771 1.82303263479838 1.19675255377204e-07 mirMAP -0.43824839759812 0.00118132940169133 NA NA NA hsa-miR-26a-5p ITGA2 -0.384110714440647 0.0442498636014044 1.82303263479838 1.19675255377204e-07 mirMAP -0.537438189144858 6.31005898652249e-05 NA NA NA hsa-miR-26b-5p ITGA2 -0.301646326928219 0.160081421968103 1.82303263479838 1.19675255377204e-07 mirMAP -0.343995930734224 0.00419056050956817 NA NA NA hsa-miR-30d-5p ITGA2 -0.5492586056147 0.0140125082460125 1.82303263479838 1.19675255377204e-07 mirMAP -0.396563759470854 0.000501652353664741 NA NA NA hsa-miR-30e-5p ITGA2 -0.573784818166736 0.0112497802572927 1.82303263479838 1.19675255377204e-07 mirMAP -0.345967862419713 0.00216432091547215 NA NA NA hsa-miR-326 ITGA2 -0.429748586406214 0.2629894124021 1.82303263479838 1.19675255377204e-07 PITA -0.272070154422955 3.78635264079111e-05 NA NA NA hsa-miR-532-5p ITGA2 0.313080805824184 0.252248939356301 1.82303263479838 1.19675255377204e-07 MirTarget -0.315619723498482 0.000695566967204546 NA NA NA hsa-miR-664a-3p ITGA2 -0.83041219170254 0.000136267547251167 1.82303263479838 1.19675255377204e-07 MirTarget;mirMAP -0.327339548650456 0.00496212045433972 NA NA NA hsa-miR-107 ITGA5 0.904627575346218 4.67936495073904e-05 -0.487036121002453 0.168143952645478 PITA;miRanda -0.547256073168904 7.34941460918876e-07 NA NA NA hsa-miR-148a-3p ITGA5 -1.53721533763578 3.55533747293117e-05 -0.487036121002453 0.168143952645478 miRNATAP -0.270995317010704 3.65184248195192e-05 NA NA NA hsa-miR-148b-3p ITGA5 0.295175884456199 0.17466422420702 -0.487036121002453 0.168143952645478 miRNAWalker2_validate -0.481857193369477 3.45374965877632e-05 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 1.65900927871187 0.000522025364980187 -0.487036121002453 0.168143952645478 miRNAWalker2_validate -0.164697749010525 0.00142809885400767 NA NA NA hsa-miR-194-3p ITGA5 0.259420201261466 0.821811295418686 -0.487036121002453 0.168143952645478 miRNATAP -0.122302090520396 9.16447145833413e-09 NA NA NA hsa-miR-25-3p ITGA5 1.00604871526544 0.000421838061147906 -0.487036121002453 0.168143952645478 miRNATAP -0.298318780537736 0.000618520918566734 NA NA NA hsa-miR-3065-3p ITGA5 -1.03551124329864 0.0218397494946288 -0.487036121002453 0.168143952645478 miRNATAP -0.176477705190929 0.00138765322111752 NA NA NA hsa-miR-30d-5p ITGA5 -0.5492586056147 0.0140125082460125 -0.487036121002453 0.168143952645478 miRNATAP -0.649219190546994 3.47116862319541e-09 NA NA NA hsa-miR-32-5p ITGA5 0.415247682945382 0.106458022460373 -0.487036121002453 0.168143952645478 miRNATAP -0.430320623699758 9.64102677167465e-06 NA NA NA hsa-miR-338-3p ITGA5 -0.959276231066179 0.0191473351014091 -0.487036121002453 0.168143952645478 miRanda -0.209832094067179 0.000557641939996973 NA NA NA hsa-miR-429 ITGA5 1.40182602301928 0.00900426780286475 -0.487036121002453 0.168143952645478 miRNATAP -0.290422350034528 6.09520099281734e-11 NA NA NA hsa-miR-629-3p ITGA5 1.40326397107309 9.7803063526732e-05 -0.487036121002453 0.168143952645478 miRNATAP -0.18625091062054 0.00679666927479237 NA NA NA hsa-miR-92a-3p ITGA5 1.2209325870225 6.8757197708107e-06 -0.487036121002453 0.168143952645478 miRNAWalker2_validate;miRTarBase;miRNATAP -0.399640081564293 8.72886817989696e-06 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-98-5p ITGA5 0.919961309193122 2.61963790596372e-05 -0.487036121002453 0.168143952645478 miRNAWalker2_validate -0.331296165506695 0.00380830552251342 NA NA NA hsa-miR-142-5p ITGAV 1.55592486377018 6.69269968016779e-06 0.170268869737817 0.518461433463577 MirTarget;PITA -0.149664657944716 0.0047233679986809 NA NA NA hsa-miR-186-5p ITGAV 0.149964130725901 0.434709542998771 0.170268869737817 0.518461433463577 mirMAP -0.412772542950313 2.95667974546309e-05 NA NA NA hsa-miR-25-3p ITGAV 1.00604871526544 0.000421838061147906 0.170268869737817 0.518461433463577 MirTarget;miRNATAP -0.199585868141085 0.00212481951830816 NA NA NA hsa-miR-30e-3p ITGAV -0.913131357083321 7.29096855615228e-06 0.170268869737817 0.518461433463577 mirMAP -0.308240881161943 0.000721691871802401 NA NA NA hsa-miR-32-5p ITGAV 0.415247682945382 0.106458022460373 0.170268869737817 0.518461433463577 miRNAWalker2_validate;MirTarget;miRNATAP -0.38747888094873 5.69126067817527e-08 NA NA NA hsa-miR-335-3p ITGAV 2.5197689063267 2.20084506976733e-09 0.170268869737817 0.518461433463577 MirTarget -0.191449056625224 4.60407294826616e-06 NA NA NA hsa-miR-33a-3p ITGAV 0.347011402017138 0.321709379745392 0.170268869737817 0.518461433463577 MirTarget -0.206373384664145 0.000226962001191522 NA NA NA hsa-miR-361-5p ITGAV 0.407725414130987 0.0181260969156347 0.170268869737817 0.518461433463577 MirTarget;miRanda -0.371270186156443 0.000822530289446712 NA NA NA hsa-miR-3928-3p ITGAV 1.3021682800308 0.00117241057113773 0.170268869737817 0.518461433463577 MirTarget -0.137920756885535 0.00982481953528062 NA NA NA hsa-miR-429 ITGAV 1.40182602301928 0.00900426780286475 0.170268869737817 0.518461433463577 miRanda -0.127573914161302 0.000194044828831387 NA NA NA hsa-miR-550a-3p ITGAV 2.05849884025997 7.99642185793604e-07 0.170268869737817 0.518461433463577 miRNATAP -0.126821324866793 0.00856356429216092 NA NA NA hsa-miR-577 ITGAV 0.911619788986754 0.2256062124148 0.170268869737817 0.518461433463577 mirMAP -0.118825771133592 1.77086835093214e-06 NA NA NA hsa-miR-590-3p ITGAV 1.11654983899947 0.000160782154924864 0.170268869737817 0.518461433463577 MirTarget;PITA;miRanda -0.173578919934922 0.00554299178876213 NA NA NA hsa-miR-7-1-3p ITGAV 0.709309110750947 0.0412301737463194 0.170268869737817 0.518461433463577 mirMAP -0.229806356496395 1.46149451924112e-05 NA NA NA hsa-miR-92a-3p ITGAV 1.2209325870225 6.8757197708107e-06 0.170268869737817 0.518461433463577 MirTarget;miRNATAP -0.225670476956276 0.000835317304585331 NA NA NA hsa-miR-139-5p ITGB1 -1.83374360776637 1.22019901002824e-09 0.267016763315638 0.217071042534738 miRanda -0.166330921446088 0.000621163759489789 NA NA NA hsa-miR-140-3p ITGB1 -0.296251775392129 0.127539826012144 0.267016763315638 0.217071042534738 PITA -0.265561587473128 0.000960278584559249 NA NA NA hsa-miR-29c-3p ITGB1 -1.62454036584589 5.38376515586029e-07 0.267016763315638 0.217071042534738 MirTarget;miRNATAP -0.177825861358882 9.78724055745933e-05 26766915 MiR 29c inhibits cell growth invasion and migration of pancreatic cancer by targeting ITGB1; Further analysis revealed that ITGB1 is one of the functional target genes of miR-29c and knockdown of ITGB1 inhibited the proliferation migration and invasion of PC cells which was similar to the effects of overexpression of miR-29c pancreatic cancer hsa-miR-769-5p ITGB1 1.14821899306381 1.27143750879772e-06 0.267016763315638 0.217071042534738 miRNAWalker2_validate -0.223517510859641 0.000419403649676611 NA NA NA hsa-let-7b-5p ITGB3 0.0582902155815681 0.781400138984745 -1.40916296337126 0.002071079307225 MirTarget;miRNATAP -0.743990749776556 2.23051840233951e-06 NA NA NA hsa-let-7d-5p ITGB3 0.981733854788227 7.26366577706469e-07 -1.40916296337126 0.002071079307225 MirTarget -0.587007460934112 0.000341791924889036 NA NA NA hsa-miR-185-5p ITGB3 1.14351510556643 1.07346945085714e-08 -1.40916296337126 0.002071079307225 MirTarget -0.700312513320449 1.10039932237541e-05 NA NA NA hsa-miR-18a-3p ITGB3 2.35188582849667 1.39401350286321e-08 -1.40916296337126 0.002071079307225 miRNATAP -0.265286573052279 0.000494514813724871 NA NA NA hsa-miR-221-3p ITGB3 1.33496247538338 3.82022531235275e-07 -1.40916296337126 0.002071079307225 MirTarget -0.56863386913382 2.28894169763649e-06 NA NA NA hsa-miR-222-3p ITGB3 1.39382731585819 9.98182478024671e-07 -1.40916296337126 0.002071079307225 MirTarget -0.494364537134536 9.0708405241597e-06 NA NA NA hsa-miR-320b ITGB3 1.11183660885284 0.000497971211648503 -1.40916296337126 0.002071079307225 miRanda -0.263575919369573 0.00998810655827514 NA NA NA hsa-miR-429 ITGB3 1.40182602301928 0.00900426780286475 -1.40916296337126 0.002071079307225 miRanda -0.228312520495241 0.000150308985352788 NA NA NA hsa-miR-590-3p ITGB3 1.11654983899947 0.000160782154924864 -1.40916296337126 0.002071079307225 PITA;miRanda -0.450666556081107 3.46805032242963e-05 NA NA NA hsa-miR-590-5p ITGB3 1.04171442093217 0.000272475544954865 -1.40916296337126 0.002071079307225 miRanda -0.508383401728035 5.98305702298863e-06 NA NA NA hsa-miR-98-5p ITGB3 0.919961309193122 2.61963790596372e-05 -1.40916296337126 0.002071079307225 miRNAWalker2_validate;MirTarget -0.457185622064576 0.00224967508049455 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-139-5p ITGB5 -1.83374360776637 1.22019901002824e-09 0.313873412412446 0.162052688227069 miRanda -0.157368931086176 0.00187918850416451 NA NA NA hsa-miR-155-5p ITGB5 1.28707757465885 8.6344688246758e-05 0.313873412412446 0.162052688227069 miRNAWalker2_validate -0.180355285878726 0.000146344857093698 NA NA NA hsa-miR-335-5p ITGB5 1.59953351087307 5.56170899867314e-05 0.313873412412446 0.162052688227069 miRNAWalker2_validate -0.103075395159209 0.00897412138238449 NA NA NA hsa-miR-378a-5p ITGB5 -0.557166502179376 0.0344581590006454 0.313873412412446 0.162052688227069 MirTarget -0.246369089955341 4.16226627825094e-05 NA NA NA hsa-miR-484 ITGB5 0.71327898984355 0.00233605130771196 0.313873412412446 0.162052688227069 miRNATAP -0.189734806183083 0.00544690869017285 NA NA NA hsa-miR-15a-5p JUN 1.03783090449383 7.40334108980898e-07 -0.77435217390261 0.0066318712851569 miRNAWalker2_validate -0.275129314608708 0.00431274574294796 NA NA NA hsa-miR-429 JUN 1.40182602301928 0.00900426780286475 -0.77435217390261 0.0066318712851569 MirTarget;PITA;miRanda;miRNATAP -0.102047702155417 0.00679958519946339 NA NA NA hsa-miR-92a-3p JUN 1.2209325870225 6.8757197708107e-06 -0.77435217390261 0.0066318712851569 miRNATAP -0.247580163718491 0.000789716327406544 NA NA NA hsa-miR-93-5p JUN 1.7515174434778 1.59386482413883e-08 -0.77435217390261 0.0066318712851569 miRNAWalker2_validate -0.201774500205283 0.00149110846021834 NA NA NA hsa-miR-590-3p LAMA2 1.11654983899947 0.000160782154924864 -2.580924730533 3.63137417662178e-07 miRanda -0.509262836011672 3.60820492706287e-05 NA NA NA hsa-miR-16-5p LAMC1 1.00515772948091 5.33912942007619e-06 -0.087353699132084 0.738376666533912 miRNAWalker2_validate;MirTarget -0.221556573401183 0.00786443769780455 NA NA NA hsa-miR-200b-3p LAMC1 0.974577911407732 0.0595020056914543 -0.087353699132084 0.738376666533912 MirTarget;TargetScan -0.148045303530752 2.60969442358224e-05 NA NA NA hsa-miR-200c-3p LAMC1 1.28185685499076 0.00369777635539177 -0.087353699132084 0.738376666533912 MirTarget;miRNATAP -0.171869049690553 2.83063474350726e-05 NA NA NA hsa-miR-29a-3p LAMC1 -0.113012156986374 0.615005009685815 -0.087353699132084 0.738376666533912 MirTarget;miRNATAP -0.287557197309806 0.00058117288722877 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.230693226193598 0.367461626035234 -0.087353699132084 0.738376666533912 MirTarget;miRNATAP -0.216042032630415 0.00316712813538642 NA NA NA hsa-miR-429 LAMC1 1.40182602301928 0.00900426780286475 -0.087353699132084 0.738376666533912 MirTarget;PITA;miRanda;miRNATAP -0.154255066108985 4.49497229292836e-06 NA NA NA hsa-miR-148b-3p LAMC2 0.295175884456199 0.17466422420702 2.65364471767322 5.14185338390863e-07 miRNAWalker2_validate -0.617031099386866 0.000641519294006906 NA NA NA hsa-miR-338-3p LAMC2 -0.959276231066179 0.0191473351014091 2.65364471767322 5.14185338390863e-07 miRanda -0.330967672847862 0.000413265986240392 NA NA NA hsa-miR-338-5p LAMC2 -1.19659203838734 0.0100316010080496 2.65364471767322 5.14185338390863e-07 mirMAP -0.280808735893256 0.000656583804816535 NA NA NA hsa-miR-375 LAMC2 -2.94506033785642 0.00570147601654791 2.65364471767322 5.14185338390863e-07 miRanda -0.201622460340746 6.63999491102235e-09 NA NA NA hsa-miR-660-5p LAMC2 -0.0206552819434673 0.938868734063643 2.65364471767322 5.14185338390863e-07 MirTarget -0.681988822774976 1.83599398734108e-06 NA NA NA hsa-miR-107 LOX 0.904627575346218 4.67936495073904e-05 0.787082399637845 0.070891026758805 miRanda -0.581365290186873 2.45712253889888e-05 NA NA NA hsa-miR-186-5p LOX 0.149964130725901 0.434709542998771 0.787082399637845 0.070891026758805 mirMAP -0.570635157559149 0.000566889088632423 NA NA NA hsa-miR-200b-3p LOX 0.974577911407732 0.0595020056914543 0.787082399637845 0.070891026758805 TargetScan -0.296492054989182 3.94897789715571e-07 NA NA NA hsa-miR-29a-3p LOX -0.113012156986374 0.615005009685815 0.787082399637845 0.070891026758805 miRNATAP -0.403004438203256 0.00423199304773774 25153510 Second the direct interaction between one of the upregulated mRNA target the LOX gene which is an EMT key player and a downregulated miRNA the miR-29a was experimentally validated by a luciferase assay in HEK cell thyroid cancer hsa-miR-29b-3p LOX -0.230693226193598 0.367461626035234 0.787082399637845 0.070891026758805 miRNATAP -0.397928012384893 0.00116412015273052 NA NA NA hsa-miR-29c-3p LOX -1.62454036584589 5.38376515586029e-07 0.787082399637845 0.070891026758805 miRNATAP -0.268549365345156 0.00404960074033714 NA NA NA hsa-miR-30d-5p LOX -0.5492586056147 0.0140125082460125 0.787082399637845 0.070891026758805 miRNATAP -0.815031253586016 1.879675260632e-09 NA NA NA hsa-miR-335-5p LOX 1.59953351087307 5.56170899867314e-05 0.787082399637845 0.070891026758805 miRNAWalker2_validate -0.335982622774208 9.26717058184044e-06 NA NA NA hsa-miR-429 LOX 1.40182602301928 0.00900426780286475 0.787082399637845 0.070891026758805 miRanda;miRNATAP -0.291551423071068 1.91084682877863e-07 NA NA NA hsa-miR-577 LOX 0.911619788986754 0.2256062124148 0.787082399637845 0.070891026758805 mirMAP -0.222396200352419 5.906338843126e-08 NA NA NA hsa-miR-335-5p LOXL1 1.59953351087307 5.56170899867314e-05 0.155892586550651 0.686941909361858 miRNAWalker2_validate -0.234858621789148 0.000514954380919388 NA NA NA hsa-miR-93-5p LOXL1 1.7515174434778 1.59386482413883e-08 0.155892586550651 0.686941909361858 miRNAWalker2_validate -0.263394210526135 0.00208080715946389 NA NA NA hsa-miR-107 LRP1 0.904627575346218 4.67936495073904e-05 -0.310119323082736 0.266297778705255 PITA;miRNATAP -0.434435165347692 5.92385400315119e-07 NA NA NA hsa-miR-185-3p LRP1 1.33711019171256 3.45756583967985e-05 -0.310119323082736 0.266297778705255 MirTarget -0.21338302626 0.000378013672233194 NA NA NA hsa-miR-200b-3p LRP1 0.974577911407732 0.0595020056914543 -0.310119323082736 0.266297778705255 TargetScan -0.145106336970951 0.000122120009866065 NA NA NA hsa-miR-324-5p LRP1 1.08820215809537 3.11674414561836e-05 -0.310119323082736 0.266297778705255 miRanda -0.223845830679876 0.0028206382765107 NA NA NA hsa-miR-335-5p LRP1 1.59953351087307 5.56170899867314e-05 -0.310119323082736 0.266297778705255 miRNAWalker2_validate -0.212579423694176 1.07423468064571e-05 NA NA NA hsa-miR-339-5p LRP1 0.770566566962108 0.00816529093411862 -0.310119323082736 0.266297778705255 miRanda -0.200680172062487 0.00312904842548501 NA NA NA hsa-miR-429 LRP1 1.40182602301928 0.00900426780286475 -0.310119323082736 0.266297778705255 PITA;miRanda;miRNATAP -0.16544472223445 4.14521903950214e-06 NA NA NA hsa-miR-590-3p LRP1 1.11654983899947 0.000160782154924864 -0.310119323082736 0.266297778705255 PITA;miRanda;miRNATAP -0.252464660378538 0.000121989856195926 NA NA NA hsa-miR-590-5p LRP1 1.04171442093217 0.000272475544954865 -0.310119323082736 0.266297778705255 miRanda -0.325274112047751 1.36517494091142e-06 NA NA NA hsa-miR-107 LRRC15 0.904627575346218 4.67936495073904e-05 0.968807710435098 0.153584529939086 PITA -0.968399932959482 5.92210104313055e-06 NA NA NA hsa-miR-140-5p LRRC15 0.208193069681326 0.303002433893804 0.968807710435098 0.153584529939086 miRanda -0.838224610969382 0.000587798873229148 NA NA NA hsa-miR-17-3p LRRC15 1.31126744284937 3.24768335024185e-07 0.968807710435098 0.153584529939086 mirMAP -0.807957967130287 8.96481208870577e-06 NA NA NA hsa-miR-200a-3p LRRC15 0.717826667295984 0.193912116506827 0.968807710435098 0.153584529939086 mirMAP -0.240760551637142 0.00584846990012422 NA NA NA hsa-miR-30b-5p LRRC15 -0.430720743745757 0.0593564057320791 0.968807710435098 0.153584529939086 mirMAP -0.851300913920913 6.17856588448806e-05 NA NA NA hsa-miR-30c-5p LRRC15 -0.983130268805942 4.60419218706127e-05 0.968807710435098 0.153584529939086 mirMAP -0.541397478439568 0.0066650820144348 NA NA NA hsa-miR-30d-5p LRRC15 -0.5492586056147 0.0140125082460125 0.968807710435098 0.153584529939086 mirMAP -1.06199681174058 7.22850608363275e-07 NA NA NA hsa-miR-30e-5p LRRC15 -0.573784818166736 0.0112497802572927 0.968807710435098 0.153584529939086 mirMAP -0.621758895425251 0.00397546345065251 NA NA NA hsa-miR-3614-5p LRRC15 1.10426689932954 0.00706308396674599 0.968807710435098 0.153584529939086 mirMAP -0.4637402287707 8.12262495903647e-05 NA NA NA hsa-miR-425-5p LRRC15 1.13924952403101 0.000255357546232931 0.968807710435098 0.153584529939086 mirMAP -0.510583314413966 0.000859903401141493 NA NA NA hsa-miR-429 LRRC15 1.40182602301928 0.00900426780286475 0.968807710435098 0.153584529939086 miRNATAP -0.262281396480639 0.00329528530673735 NA NA NA hsa-miR-16-2-3p LUM 1.8048179609245 2.83095715136409e-09 0.949011229143216 0.0290106429864412 mirMAP -0.290402829796599 0.0031777805489268 NA NA NA hsa-miR-590-3p LUM 1.11654983899947 0.000160782154924864 0.949011229143216 0.0290106429864412 miRanda;mirMAP -0.280534606986968 0.00703000755745427 NA NA NA hsa-miR-590-5p LUM 1.04171442093217 0.000272475544954865 0.949011229143216 0.0290106429864412 MirTarget;PITA;miRanda -0.357464569857432 0.000864845731900045 NA NA NA hsa-miR-7-1-3p LUM 0.709309110750947 0.0412301737463194 0.949011229143216 0.0290106429864412 mirMAP -0.354708873977675 6.04334673214741e-05 NA NA NA hsa-miR-30d-3p MAGEE1 -0.545113326540761 0.0433733076874155 -1.36906392281595 0.0133854907235856 MirTarget -0.532145488492481 0.000291208430262917 NA NA NA hsa-miR-362-3p MAGEE1 -0.0349414695893027 0.913780708043777 -1.36906392281595 0.0133854907235856 miRanda -0.448286485027873 0.00027323663512056 NA NA NA hsa-miR-125a-3p MATN2 1.19506542853853 0.00164364545717311 -0.89352963721833 0.0558158211425777 miRanda -0.228215515847655 0.00960382180911184 NA NA NA hsa-miR-335-3p MATN2 2.5197689063267 2.20084506976733e-09 -0.89352963721833 0.0558158211425777 mirMAP -0.226519877235844 0.00277592991111069 NA NA NA hsa-miR-543 MATN2 0.0323775903217254 0.929458442755522 -0.89352963721833 0.0558158211425777 miRanda -0.289162964491091 0.00415175313339031 NA NA NA hsa-miR-590-3p MATN2 1.11654983899947 0.000160782154924864 -0.89352963721833 0.0558158211425777 miRanda;mirMAP;miRNATAP -0.347589936798787 0.00180408216557826 NA NA NA hsa-miR-590-5p MATN2 1.04171442093217 0.000272475544954865 -0.89352963721833 0.0558158211425777 PITA;miRanda;miRNATAP -0.43087656975737 0.000173687954304814 NA NA NA hsa-miR-145-5p MEST -1.75133578902314 1.54965572197748e-05 2.38257859229659 3.06795728532586e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.241989192572129 0.000359900057239095 NA NA NA hsa-miR-29c-3p MEST -1.62454036584589 5.38376515586029e-07 2.38257859229659 3.06795728532586e-10 MirTarget;miRNATAP -0.32681122428022 0.000103630534912158 NA NA NA hsa-miR-126-5p MFAP5 0.41765430251855 0.0753161203651532 -3.31829950601352 0.000230029798224786 mirMAP -1.38899209057227 4.35418227385631e-07 NA NA NA hsa-miR-1262 MFAP5 -0.294807684508223 0.393241029438464 -3.31829950601352 0.000230029798224786 MirTarget -0.61905293956751 0.00165554228153318 NA NA NA hsa-miR-15a-5p MFAP5 1.03783090449383 7.40334108980898e-07 -3.31829950601352 0.000230029798224786 MirTarget -1.83708206823725 5.5591119596845e-10 NA NA NA hsa-miR-15b-3p MFAP5 1.75738933306437 3.00554466232543e-08 -3.31829950601352 0.000230029798224786 MirTarget -1.15194065279649 1.98731424945864e-09 NA NA NA hsa-miR-15b-5p MFAP5 1.62046407540723 5.42152621571078e-09 -3.31829950601352 0.000230029798224786 MirTarget -1.36167074352978 4.40583996441501e-10 NA NA NA hsa-miR-16-5p MFAP5 1.00515772948091 5.33912942007619e-06 -3.31829950601352 0.000230029798224786 MirTarget -1.64828648930967 6.05876276109406e-09 NA NA NA hsa-miR-200b-3p MFAP5 0.974577911407732 0.0595020056914543 -3.31829950601352 0.000230029798224786 TargetScan -0.757335411899201 3.2696254751779e-10 NA NA NA hsa-miR-200c-3p MFAP5 1.28185685499076 0.00369777635539177 -3.31829950601352 0.000230029798224786 miRNATAP -0.818952204560912 7.20272625552525e-09 NA NA NA hsa-miR-32-3p MFAP5 0.583525764322974 0.11837203008551 -3.31829950601352 0.000230029798224786 mirMAP -0.832034615414952 1.78396100901641e-05 NA NA NA hsa-miR-320a MFAP5 0.593888711838028 0.011897419390526 -3.31829950601352 0.000230029798224786 miRanda -1.18522098813376 1.58710810567243e-05 NA NA NA hsa-miR-320b MFAP5 1.11183660885284 0.000497971211648503 -3.31829950601352 0.000230029798224786 miRanda -0.961662028975094 1.24678730514257e-06 NA NA NA hsa-miR-320c MFAP5 0.455072851945474 0.240613785444485 -3.31829950601352 0.000230029798224786 miRanda -0.61897730338833 0.00146416084613451 NA NA NA hsa-miR-33a-3p MFAP5 0.347011402017138 0.321709379745392 -3.31829950601352 0.000230029798224786 MirTarget -0.767622090218733 8.09680395250213e-05 NA NA NA hsa-miR-3662 MFAP5 1.82780708047676 0.0054036501346178 -3.31829950601352 0.000230029798224786 miRNATAP -0.526384977463862 2.77957487120046e-05 NA NA NA hsa-miR-429 MFAP5 1.40182602301928 0.00900426780286475 -3.31829950601352 0.000230029798224786 miRanda;miRNATAP -0.755589296957106 5.14223306614529e-11 NA NA NA hsa-miR-590-3p MFAP5 1.11654983899947 0.000160782154924864 -3.31829950601352 0.000230029798224786 miRanda;mirMAP -0.961506429850956 7.63683755929128e-06 NA NA NA hsa-miR-944 MGP 3.33123095809751 0.0177835044930391 -1.31881184739579 0.00869402360315523 MirTarget -0.103913886093736 0.000544802944172223 NA NA NA hsa-miR-145-5p MMP1 -1.75133578902314 1.54965572197748e-05 4.94576388704253 1.69627357587889e-11 miRNAWalker2_validate -0.560811995361659 2.12110228018649e-05 NA NA NA hsa-miR-150-5p MMP14 0.147461377429675 0.753719621305461 1.54176613839397 1.83938928810036e-07 miRNATAP -0.234106968010761 2.0725601229889e-07 NA NA NA hsa-miR-26a-5p MMP14 -0.384110714440647 0.0442498636014044 1.54176613839397 1.83938928810036e-07 miRNATAP -0.407245385908267 0.000429009670352843 NA NA NA hsa-miR-26b-5p MMP14 -0.301646326928219 0.160081421968103 1.54176613839397 1.83938928810036e-07 miRNATAP -0.377729902754342 0.000219807458092898 NA NA NA hsa-miR-29b-2-5p MMP14 -1.7015307882027 2.84239251703401e-10 1.54176613839397 1.83938928810036e-07 mirMAP -0.473233300015742 1.77188204014091e-10 NA NA NA hsa-miR-3065-3p MMP14 -1.03551124329864 0.0218397494946288 1.54176613839397 1.83938928810036e-07 miRNATAP -0.141691223394131 0.0029936221744419 NA NA NA hsa-miR-335-5p MMP14 1.59953351087307 5.56170899867314e-05 1.54176613839397 1.83938928810036e-07 miRNAWalker2_validate -0.1896951704425 0.000380844310515063 NA NA NA hsa-miR-361-3p MMP14 -0.126462931388735 0.566052688733137 1.54176613839397 1.83938928810036e-07 mirMAP -0.553098574424101 1.33727217662875e-08 NA NA NA hsa-miR-374a-5p MMP14 -0.116485410477589 0.554703396010082 1.54176613839397 1.83938928810036e-07 MirTarget -0.32385158543935 0.00412489417982149 NA NA NA hsa-miR-532-3p MMP14 0.552364451472481 0.0975490365586023 1.54176613839397 1.83938928810036e-07 miRNATAP -0.302940287977861 2.25245514701539e-06 NA NA NA hsa-miR-625-5p MMP14 0.537211086526376 0.203801009380384 1.54176613839397 1.83938928810036e-07 mirMAP -0.260054717087378 2.45381349485097e-07 NA NA NA hsa-miR-142-3p MMP2 1.32364054836498 0.0001537753622128 0.0939868169490197 0.83323469391746 miRanda -0.279935703788955 0.0017080570419356 NA NA NA hsa-miR-17-5p MMP2 1.65862087862483 8.45603406215941e-08 0.0939868169490197 0.83323469391746 miRNAWalker2_validate;TargetScan -0.36752274567918 0.000197032785338686 NA NA NA hsa-miR-2110 MMP2 0.759864042760204 0.0723961390557655 0.0939868169490197 0.83323469391746 miRNATAP -0.201133095036466 0.00806932884996287 NA NA NA hsa-miR-29a-3p MMP2 -0.113012156986374 0.615005009685815 0.0939868169490197 0.83323469391746 miRNATAP -0.533505831285115 0.00018438398656482 24130168 We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC gastric cancer hsa-miR-29b-3p MMP2 -0.230693226193598 0.367461626035234 0.0939868169490197 0.83323469391746 miRNAWalker2_validate;miRTarBase;miRNATAP -0.479003272647134 0.000116622998372055 25866219;26155940;20657750;24130681;24130168;26063204 miR 29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP 2; The impact of overexpression of miR-29b on putative target MMP-2 were subsequently confirmed via Western blot; Overexpression of miR-29b significantly decreased p<0.05 the protein level of MMP-2 which has previously been identified as a direct target of miR-29b; Thus our study demonstrated that overexpression of miR-29b inhibits tumor growth in part by targeting MMP-2;In this study we found that only miR-29b inhibited tumor cell migration and invasion by reducing MMP-2 activity via phospho-AKT/β-catenin signaling and stimulated a more epithelial-like morphology;Further a novel target with potential implications for invasion and metastasis matrix metallopeptidase-2 MMP-2 was identified and confirmed to be a miR-29b target in prostate cancer cells;Since miR-29b plays a role in regulating the migration of cancer cells we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 MMP-2 thereby suppressing the migration of colon cancer cells; Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA; Western blotting and quantitative RT-PCR indicated that miR-29b down-regulated the expression of MMP2 at the protein and mRNA levels; Taken together our results demonstrate that miR-29b serves as a tumor metastasis suppressor which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression progression;cell migration;metastasis;;;metastasis esophageal cancer;glioblastoma;prostate cancer;colon cancer;gastric cancer;lung squamous cell cancer hsa-miR-3065-3p MMP2 -1.03551124329864 0.0218397494946288 0.0939868169490197 0.83323469391746 miRNATAP -0.20468182071692 0.00334654243573434 NA NA NA hsa-miR-330-3p MMP2 0.798460296022179 0.00746538156533435 0.0939868169490197 0.83323469391746 miRNATAP -0.455952122112536 1.32672375011035e-05 NA NA NA hsa-miR-335-5p MMP2 1.59953351087307 5.56170899867314e-05 0.0939868169490197 0.83323469391746 miRNAWalker2_validate -0.380662481862952 7.24604712655015e-07 NA NA NA hsa-miR-338-3p MMP2 -0.959276231066179 0.0191473351014091 0.0939868169490197 0.83323469391746 miRNAWalker2_validate -0.303889468572858 6.79588970794077e-05 NA NA NA hsa-miR-139-5p MSX1 -1.83374360776637 1.22019901002824e-09 0.779014149960009 0.0521414819007669 miRanda -0.276621887821589 0.00239277168176176 NA NA NA hsa-miR-144-3p MXRA5 -0.13309578176575 0.798245647923351 0.731190085702667 0.119119036943906 MirTarget;miRNATAP -0.257264255693453 6.17231116267798e-05 NA NA NA hsa-miR-30d-5p MXRA5 -0.5492586056147 0.0140125082460125 0.731190085702667 0.119119036943906 miRNATAP -0.402379650613325 0.00788127453835417 NA NA NA hsa-miR-330-5p MYL9 0.488365986827708 0.0512207630808233 -1.97370715679379 5.16357680388141e-05 MirTarget;miRanda -0.75388391186992 5.42204175633079e-08 NA NA NA hsa-let-7f-1-3p MYLK 1.28704406797397 1.17954701106157e-06 -1.7820882955471 0.00021299880658384 mirMAP -0.58693324778838 3.66006950647318e-06 NA NA NA hsa-miR-107 MYLK 0.904627575346218 4.67936495073904e-05 -1.7820882955471 0.00021299880658384 miRanda -0.958307701314697 1.59486727685381e-10 NA NA NA hsa-miR-126-5p MYLK 0.41765430251855 0.0753161203651532 -1.7820882955471 0.00021299880658384 mirMAP -0.550933516650201 0.000217446206656788 NA NA NA hsa-miR-142-3p MYLK 1.32364054836498 0.0001537753622128 -1.7820882955471 0.00021299880658384 PITA;miRanda -0.373939123539369 0.000121768559207994 NA NA NA hsa-miR-142-5p MYLK 1.55592486377018 6.69269968016779e-06 -1.7820882955471 0.00021299880658384 mirMAP -0.35749494899806 0.000262904212742449 NA NA NA hsa-miR-15a-5p MYLK 1.03783090449383 7.40334108980898e-07 -1.7820882955471 0.00021299880658384 MirTarget;miRNATAP -0.932968680237115 4.33292673965447e-09 NA NA NA hsa-miR-15b-5p MYLK 1.62046407540723 5.42152621571078e-09 -1.7820882955471 0.00021299880658384 MirTarget;miRNATAP -0.841063532057314 1.88328310926937e-13 NA NA NA hsa-miR-16-2-3p MYLK 1.8048179609245 2.83095715136409e-09 -1.7820882955471 0.00021299880658384 mirMAP -0.728385278787531 3.80638567204312e-12 NA NA NA hsa-miR-16-5p MYLK 1.00515772948091 5.33912942007619e-06 -1.7820882955471 0.00021299880658384 MirTarget;miRNATAP -1.18362831565421 3.79200664096346e-16 NA NA NA hsa-miR-186-5p MYLK 0.149964130725901 0.434709542998771 -1.7820882955471 0.00021299880658384 mirMAP -0.882576966489943 1.34824728136179e-06 NA NA NA hsa-miR-192-3p MYLK 0.355565421687399 0.74117031340037 -1.7820882955471 0.00021299880658384 MirTarget -0.201771955295132 1.26078066406438e-10 NA NA NA hsa-miR-200b-3p MYLK 0.974577911407732 0.0595020056914543 -1.7820882955471 0.00021299880658384 TargetScan -0.5439510444541 6.91520848070929e-19 NA NA NA hsa-miR-32-3p MYLK 0.583525764322974 0.11837203008551 -1.7820882955471 0.00021299880658384 mirMAP -0.555333878722866 5.2954720445082e-08 NA NA NA hsa-miR-320a MYLK 0.593888711838028 0.011897419390526 -1.7820882955471 0.00021299880658384 miRanda -0.555758545722269 0.000163318678659407 NA NA NA hsa-miR-320b MYLK 1.11183660885284 0.000497971211648503 -1.7820882955471 0.00021299880658384 miRanda -0.571707405052866 5.29938198685378e-08 NA NA NA hsa-miR-320c MYLK 0.455072851945474 0.240613785444485 -1.7820882955471 0.00021299880658384 miRanda -0.389386444811324 0.000163834943283509 NA NA NA hsa-miR-335-3p MYLK 2.5197689063267 2.20084506976733e-09 -1.7820882955471 0.00021299880658384 mirMAP -0.488649156953672 1.14666802335056e-10 NA NA NA hsa-miR-33a-3p MYLK 0.347011402017138 0.321709379745392 -1.7820882955471 0.00021299880658384 mirMAP -0.542591791547544 1.13678231072546e-07 NA NA NA hsa-miR-362-5p MYLK -0.354508685915981 0.354912078595613 -1.7820882955471 0.00021299880658384 TargetScan;miRNATAP -0.371993440691856 3.53389382696765e-05 NA NA NA hsa-miR-3653-3p MYLK 0.599121955934704 0.0943943486072891 -1.7820882955471 0.00021299880658384 MirTarget -0.398013599379362 3.62257329752462e-05 NA NA NA hsa-miR-3682-3p MYLK 1.96838261925327 4.94885331227292e-06 -1.7820882955471 0.00021299880658384 mirMAP -0.581794562630167 9.05332908696375e-11 NA NA NA hsa-miR-424-5p MYLK 1.08509868581983 0.000420473853818268 -1.7820882955471 0.00021299880658384 MirTarget;miRNATAP -0.631707388119607 5.84567254431492e-09 NA NA NA hsa-miR-429 MYLK 1.40182602301928 0.00900426780286475 -1.7820882955471 0.00021299880658384 PITA;miRanda;miRNATAP -0.558935448293217 3.67118604761134e-22 NA NA NA hsa-miR-501-5p MYLK 0.266919328110625 0.454779001968586 -1.7820882955471 0.00021299880658384 MirTarget;PITA;miRNATAP -0.535174053872178 1.69607404865347e-08 NA NA NA hsa-miR-576-5p MYLK 0.625714137488957 0.0417100301848969 -1.7820882955471 0.00021299880658384 PITA;mirMAP -0.567481230509727 3.10971871355857e-07 NA NA NA hsa-miR-577 MYLK 0.911619788986754 0.2256062124148 -1.7820882955471 0.00021299880658384 PITA -0.358081549109816 3.12633401547301e-16 NA NA NA hsa-miR-582-5p MYLK -0.448820171762719 0.134615974001015 -1.7820882955471 0.00021299880658384 PITA;mirMAP -0.481295142309546 2.95488963213963e-05 NA NA NA hsa-miR-589-3p MYLK 1.01962606923682 0.00577853347252709 -1.7820882955471 0.00021299880658384 mirMAP -0.458873112613468 5.47367969570112e-07 NA NA NA hsa-miR-590-3p MYLK 1.11654983899947 0.000160782154924864 -1.7820882955471 0.00021299880658384 MirTarget;miRanda;mirMAP -0.720219830223345 1.09418072326177e-10 NA NA NA hsa-miR-590-5p MYLK 1.04171442093217 0.000272475544954865 -1.7820882955471 0.00021299880658384 miRanda -0.812418373176451 1.21978178405655e-12 NA NA NA hsa-miR-101-3p NID2 -0.451263906815861 0.0283387250173031 1.12672564402673 0.00610923175336568 miRNATAP -0.604135296795346 2.6757231294068e-05 NA NA NA hsa-miR-139-5p NID2 -1.83374360776637 1.22019901002824e-09 1.12672564402673 0.00610923175336568 miRanda -0.396825732420442 1.85754334765069e-05 NA NA NA hsa-miR-103a-3p NOTCH2 0.840525139266028 5.83536475789158e-07 -0.258396659712914 0.287754032641363 MirTarget -0.37130303738704 0.000279620250229799 NA NA NA hsa-miR-106a-5p NOTCH2 -0.173255688252641 0.642872703263671 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.134670778156744 0.00358480805526076 NA NA NA hsa-miR-107 NOTCH2 0.904627575346218 4.67936495073904e-05 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.362745024515323 1.75816911688454e-06 NA NA NA hsa-miR-130b-5p NOTCH2 0.701350393759937 0.0510142718395002 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;MirTarget -0.182461536764061 0.000122195576781823 NA NA NA hsa-miR-15a-5p NOTCH2 1.03783090449383 7.40334108980898e-07 -0.258396659712914 0.287754032641363 MirTarget -0.375602682643082 2.61047740143889e-06 NA NA NA hsa-miR-15b-5p NOTCH2 1.62046407540723 5.42152621571078e-09 -0.258396659712914 0.287754032641363 MirTarget -0.218321650065076 0.000248378857529312 NA NA NA hsa-miR-16-1-3p NOTCH2 1.43227522002564 3.70920454953168e-08 -0.258396659712914 0.287754032641363 mirMAP -0.189056212946732 0.00334687783906731 NA NA NA hsa-miR-16-5p NOTCH2 1.00515772948091 5.33912942007619e-06 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;MirTarget -0.390125832404426 2.46868571108581e-07 NA NA NA hsa-miR-17-5p NOTCH2 1.65862087862483 8.45603406215941e-08 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.240734585235498 6.00759166843726e-06 NA NA NA hsa-miR-183-5p NOTCH2 1.65900927871187 0.000522025364980187 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.116073706664705 0.0010305717197732 NA NA NA hsa-miR-185-5p NOTCH2 1.14351510556643 1.07346945085714e-08 -0.258396659712914 0.287754032641363 MirTarget -0.277697934863656 0.000990946267662949 NA NA NA hsa-miR-186-5p NOTCH2 0.149964130725901 0.434709542998771 -0.258396659712914 0.287754032641363 mirMAP -0.315079207848107 0.000596614775520951 NA NA NA hsa-miR-18a-3p NOTCH2 2.35188582849667 1.39401350286321e-08 -0.258396659712914 0.287754032641363 MirTarget -0.16301571486915 3.90441573914245e-05 NA NA NA hsa-miR-200a-5p NOTCH2 1.50371809098978 0.00263602434344863 -0.258396659712914 0.287754032641363 mirMAP -0.132279563777275 8.8223850239445e-05 NA NA NA hsa-miR-200b-5p NOTCH2 0.969871521250413 0.0530500454130183 -0.258396659712914 0.287754032641363 mirMAP -0.16044033769968 5.50353470025474e-06 NA NA NA hsa-miR-25-3p NOTCH2 1.00604871526544 0.000421838061147906 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.191609471166706 0.00136236952156121 NA NA NA hsa-miR-29b-3p NOTCH2 -0.230693226193598 0.367461626035234 -0.258396659712914 0.287754032641363 MirTarget -0.19020760295181 0.00526317431666269 NA NA NA hsa-miR-30b-5p NOTCH2 -0.430720743745757 0.0593564057320791 -0.258396659712914 0.287754032641363 mirMAP -0.243398888161778 0.00140836082647822 NA NA NA hsa-miR-34a-5p NOTCH2 0.794251341270032 0.00024017386701179 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;miRNATAP -0.222834716084215 0.00530683291806908 NA NA NA hsa-miR-423-5p NOTCH2 0.832613878736338 0.000791321227103338 -0.258396659712914 0.287754032641363 MirTarget -0.246500683034312 0.000354168024158134 NA NA NA hsa-miR-424-5p NOTCH2 1.08509868581983 0.000420473853818268 -0.258396659712914 0.287754032641363 MirTarget -0.218043314320312 7.32759617574408e-05 NA NA NA hsa-miR-429 NOTCH2 1.40182602301928 0.00900426780286475 -0.258396659712914 0.287754032641363 miRNATAP -0.154239970569199 7.26863729806803e-07 NA NA NA hsa-miR-577 NOTCH2 0.911619788986754 0.2256062124148 -0.258396659712914 0.287754032641363 mirMAP -0.126589383005886 2.41147864594981e-08 NA NA NA hsa-miR-590-3p NOTCH2 1.11654983899947 0.000160782154924864 -0.258396659712914 0.287754032641363 miRanda -0.202031782346418 0.000426730313491696 NA NA NA hsa-miR-590-5p NOTCH2 1.04171442093217 0.000272475544954865 -0.258396659712914 0.287754032641363 miRanda -0.209783768432532 0.000414336706503807 NA NA NA hsa-miR-7-1-3p NOTCH2 0.709309110750947 0.0412301737463194 -0.258396659712914 0.287754032641363 MirTarget;mirMAP -0.211405839302402 1.52902329147166e-05 NA NA NA hsa-miR-92a-3p NOTCH2 1.2209325870225 6.8757197708107e-06 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.285963635382967 3.25606725858084e-06 NA NA NA hsa-miR-940 NOTCH2 1.64406174271686 0.000690854900107004 -0.258396659712914 0.287754032641363 MirTarget -0.129438918335928 0.00176726076839653 NA NA NA hsa-miR-125a-5p NT5E -0.878090699011564 0.000213630844319685 0.631786213687493 0.195751319595662 miRanda -0.428767571018253 0.00337593377317508 NA NA NA hsa-miR-130b-5p NTM 0.701350393759937 0.0510142718395002 0.634455133058685 0.221081081024777 miRNATAP -0.275522522390517 0.00733496697482344 NA NA NA hsa-miR-188-5p NTM 1.35426907033843 0.00038346077691455 0.634455133058685 0.221081081024777 miRNATAP -0.363014893423969 0.000127458387527675 NA NA NA hsa-miR-30b-3p NTM -0.266398938200332 0.400847813143994 0.634455133058685 0.221081081024777 MirTarget -0.605623321819019 1.12186554033328e-07 NA NA NA hsa-miR-30d-5p NTM -0.5492586056147 0.0140125082460125 0.634455133058685 0.221081081024777 miRNATAP -0.89570695325303 3.39081046317374e-08 NA NA NA hsa-miR-339-5p NTM 0.770566566962108 0.00816529093411862 0.634455133058685 0.221081081024777 miRanda -0.369135846545957 0.00356247662441532 NA NA NA hsa-miR-33a-3p NTM 0.347011402017138 0.321709379745392 0.634455133058685 0.221081081024777 mirMAP -0.491568097559292 7.36062112906005e-06 NA NA NA hsa-miR-429 NTM 1.40182602301928 0.00900426780286475 0.634455133058685 0.221081081024777 miRanda;miRNATAP -0.271304630838812 5.72334241606736e-05 NA NA NA hsa-miR-942-5p NTM 1.90585138008274 3.11903311044863e-09 0.634455133058685 0.221081081024777 MirTarget -0.343372523476033 0.00183972910102477 NA NA NA hsa-miR-192-5p PCOLCE2 0.0809146624034405 0.941057093528709 -1.47544327277923 0.0516704290247796 miRNAWalker2_validate -0.233612838959786 1.35862166640952e-06 NA NA NA hsa-miR-215-5p PCOLCE2 0.715250240418615 0.573784317311889 -1.47544327277923 0.0516704290247796 miRNAWalker2_validate -0.200412653679671 1.44877324861507e-06 NA NA NA hsa-miR-501-5p PCOLCE2 0.266919328110625 0.454779001968586 -1.47544327277923 0.0516704290247796 MirTarget;PITA -0.411067120238134 0.00699992557468699 NA NA NA hsa-miR-3127-5p PDGFRB 0.98677589413294 0.00734249049849 0.844690963059587 0.0248980975397874 mirMAP -0.216339467888686 0.00297551716216838 NA NA NA hsa-miR-664a-3p PDGFRB -0.83041219170254 0.000136267547251167 0.844690963059587 0.0248980975397874 MirTarget -0.351564932871264 0.00450301463469565 NA NA NA hsa-miR-326 PDLIM4 -0.429748586406214 0.2629894124021 -0.193073601636915 0.711704653110054 miRanda -0.44180929853973 4.49432691038263e-06 NA NA NA hsa-miR-330-5p PDLIM4 0.488365986827708 0.0512207630808233 -0.193073601636915 0.711704653110054 miRanda -0.483570701142045 0.0011839972696949 NA NA NA hsa-miR-335-5p PDLIM4 1.59953351087307 5.56170899867314e-05 -0.193073601636915 0.711704653110054 miRNAWalker2_validate -0.461563772674117 2.70711473970127e-07 NA NA NA hsa-miR-362-3p PDLIM4 -0.0349414695893027 0.913780708043777 -0.193073601636915 0.711704653110054 miRanda -0.582630001045378 2.80124680153639e-07 NA NA NA hsa-miR-3662 PDLIM4 1.82780708047676 0.0054036501346178 -0.193073601636915 0.711704653110054 MirTarget -0.245117329344804 0.000674969703180123 NA NA NA hsa-miR-140-5p PFN2 0.208193069681326 0.303002433893804 1.01274949060731 0.0468210828384982 PITA;miRanda -0.605886198088757 0.000965059738078343 NA NA NA hsa-miR-150-5p PFN2 0.147461377429675 0.753719621305461 1.01274949060731 0.0468210828384982 miRNATAP -0.286522266276144 0.000193037594784796 NA NA NA hsa-miR-194-5p PFN2 -0.127742909829168 0.906065815804667 1.01274949060731 0.0468210828384982 miRNATAP -0.247062672227031 2.72601778259771e-15 NA NA NA hsa-miR-338-3p PFN2 -0.959276231066179 0.0191473351014091 1.01274949060731 0.0468210828384982 miRanda -0.483393905486473 1.75360593153686e-08 NA NA NA hsa-miR-7-5p PFN2 1.63575693499363 0.0124424214624534 1.01274949060731 0.0468210828384982 miRNAWalker2_validate;miRNATAP -0.183139237796713 0.00147010687918691 NA NA NA hsa-miR-139-5p PLAUR -1.83374360776637 1.22019901002824e-09 1.79219087527369 3.15798914734995e-07 miRanda -0.372492194298071 3.78705209361328e-06 NA NA NA hsa-miR-143-3p PLAUR -0.661937718854688 0.0483213962135842 1.79219087527369 3.15798914734995e-07 miRNATAP -0.23776103019094 0.00190979825650821 NA NA NA hsa-miR-195-3p PLAUR -1.34779269408059 2.01619826639376e-05 1.79219087527369 3.15798914734995e-07 MirTarget -0.352235187933 8.78610184540957e-06 NA NA NA hsa-miR-126-5p PLOD2 0.41765430251855 0.0753161203651532 -0.0022820832450714 0.995169963547456 mirMAP -0.482064593686103 2.33766794610231e-05 NA NA NA hsa-miR-429 PLOD2 1.40182602301928 0.00900426780286475 -0.0022820832450714 0.995169963547456 miRanda -0.158738090918023 0.00126621239207492 NA NA NA hsa-miR-10b-5p PMEPA1 -0.304747636331676 0.312390370183001 1.72224965314496 4.23507857289934e-05 mirMAP -0.334310592117743 0.000989742607599317 NA NA NA hsa-miR-129-5p PMEPA1 -2.56914016541176 2.36237896095709e-06 1.72224965314496 4.23507857289934e-05 MirTarget;miRanda;miRNATAP -0.14715168369873 0.00806594906790963 NA NA NA hsa-miR-582-5p PMEPA1 -0.448820171762719 0.134615974001015 1.72224965314496 4.23507857289934e-05 miRNATAP -0.274419117110368 0.00737298230470204 NA NA NA hsa-miR-9-5p PMEPA1 -0.195328736653048 0.761470692992178 1.72224965314496 4.23507857289934e-05 mirMAP -0.146719803856575 0.00189463236819739 NA NA NA hsa-miR-26b-5p PMP22 -0.301646326928219 0.160081421968103 -0.581228724003745 0.0859465245797635 miRNAWalker2_validate -0.438976411306325 0.000107803146539674 NA NA NA hsa-miR-30b-3p PMP22 -0.266398938200332 0.400847813143994 -0.581228724003745 0.0859465245797635 MirTarget -0.253386414094674 0.000881584944061858 NA NA NA hsa-miR-361-5p PMP22 0.407725414130987 0.0181260969156347 -0.581228724003745 0.0859465245797635 miRanda -0.447532830609061 0.00180952530027658 NA NA NA hsa-miR-429 PMP22 1.40182602301928 0.00900426780286475 -0.581228724003745 0.0859465245797635 PITA;miRanda;miRNATAP -0.234714270585657 5.92671688244453e-08 NA NA NA hsa-miR-505-3p PMP22 0.82660100642669 0.00111666333288398 -0.581228724003745 0.0859465245797635 MirTarget;miRNATAP -0.317801910904568 0.000785708708010584 NA NA NA hsa-miR-582-5p PMP22 -0.448820171762719 0.134615974001015 -0.581228724003745 0.0859465245797635 PITA;miRNATAP -0.232573559122525 0.00398593836845682 NA NA NA hsa-miR-590-3p PMP22 1.11654983899947 0.000160782154924864 -0.581228724003745 0.0859465245797635 miRanda -0.338084067974754 2.19925783464461e-05 NA NA NA hsa-miR-651-5p PMP22 0.668780396585739 0.0600532880935192 -0.581228724003745 0.0859465245797635 MirTarget -0.288172297766176 1.93224725505006e-05 NA NA NA hsa-miR-9-5p PMP22 -0.195328736653048 0.761470692992178 -0.581228724003745 0.0859465245797635 MirTarget;miRNATAP -0.108271958596627 0.00376147386682919 NA NA NA hsa-miR-139-5p POSTN -1.83374360776637 1.22019901002824e-09 0.230448910446015 0.682385391888687 miRanda -0.672436072653814 6.13045600085737e-08 NA NA NA hsa-miR-140-5p POSTN 0.208193069681326 0.303002433893804 0.230448910446015 0.682385391888687 miRanda -0.650127743965832 0.0012976874204513 NA NA NA hsa-miR-335-3p POSTN 2.5197689063267 2.20084506976733e-09 0.230448910446015 0.682385391888687 mirMAP -0.256539470891985 0.00482398057156629 NA NA NA hsa-let-7g-5p PRRX1 0.325297685027927 0.241142963826631 1.07480943364119 0.0439401613521789 MirTarget;miRNATAP -0.470895467999336 0.000638010667643662 NA NA NA hsa-miR-106b-5p PRRX1 1.70863907461894 2.04074794107142e-08 1.07480943364119 0.0439401613521789 MirTarget;miRNATAP -0.381723522440633 0.00157967607987454 26617763 Down regualtion of miR 106b induces epithelial mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer; We identified Prrx1 was a direct target of miR-106b through using target prediction algorithms and dual-Luciferase reporter assay; Moreover Moreover we also found TGF-β1 could down-regulate miR-106b and simultaneously miR-106b also influences the expression of TGF-β1 establishing a negative feedback loop to regulate the expression of Prrx1 together colorectal cancer hsa-miR-126-5p PRRX1 0.41765430251855 0.0753161203651532 1.07480943364119 0.0439401613521789 mirMAP -0.70801033971643 1.24743918646031e-05 NA NA NA hsa-miR-139-5p PRRX1 -1.83374360776637 1.22019901002824e-09 1.07480943364119 0.0439401613521789 miRanda -0.533029209705328 8.39454674254133e-06 NA NA NA hsa-miR-144-3p PRRX1 -0.13309578176575 0.798245647923351 1.07480943364119 0.0439401613521789 MirTarget -0.228468531005112 0.00196536857943405 NA NA NA hsa-miR-148b-5p PRRX1 1.04409494910362 0.00195860954157389 1.07480943364119 0.0439401613521789 MirTarget -0.391345895831184 0.000456302091960982 NA NA NA hsa-miR-186-5p PRRX1 0.149964130725901 0.434709542998771 1.07480943364119 0.0439401613521789 mirMAP -0.88220763218999 1.14684783257576e-05 NA NA NA hsa-miR-1976 PRRX1 0.923172654386147 0.000118514313506673 1.07480943364119 0.0439401613521789 MirTarget;miRNATAP -0.502262120760602 0.00147139983065266 NA NA NA hsa-miR-200b-5p PRRX1 0.969871521250413 0.0530500454130183 1.07480943364119 0.0439401613521789 mirMAP -0.57613035011049 9.0743874525198e-15 NA NA NA hsa-miR-26b-3p PRRX1 -0.0103961389461977 0.965770899625511 1.07480943364119 0.0439401613521789 MirTarget -0.817285557191009 1.5698178947883e-07 NA NA NA hsa-miR-29a-5p PRRX1 0.585084040404152 0.023014129158495 1.07480943364119 0.0439401613521789 mirMAP -0.478391457280268 0.00128239341182011 NA NA NA hsa-miR-29b-1-5p PRRX1 0.606560155953522 0.116355599574769 1.07480943364119 0.0439401613521789 MirTarget -0.363822481404397 0.000211381436121023 NA NA NA hsa-miR-32-3p PRRX1 0.583525764322974 0.11837203008551 1.07480943364119 0.0439401613521789 mirMAP;miRNATAP -0.454114461816711 6.5411030619708e-05 NA NA NA hsa-miR-320b PRRX1 1.11183660885284 0.000497971211648503 1.07480943364119 0.0439401613521789 miRanda -0.39887528768202 0.000707250377737527 NA NA NA hsa-miR-320c PRRX1 0.455072851945474 0.240613785444485 1.07480943364119 0.0439401613521789 miRanda -0.328184610055053 0.00399607780898572 NA NA NA hsa-miR-330-3p PRRX1 0.798460296022179 0.00746538156533435 1.07480943364119 0.0439401613521789 PITA;miRNATAP -0.461904275169251 0.000267759824620593 NA NA NA hsa-miR-335-3p PRRX1 2.5197689063267 2.20084506976733e-09 1.07480943364119 0.0439401613521789 MirTarget;mirMAP -0.301519837555848 0.000466686527614191 NA NA NA hsa-miR-338-3p PRRX1 -0.959276231066179 0.0191473351014091 1.07480943364119 0.0439401613521789 miRanda -0.57822580702112 6.90017870973052e-11 NA NA NA hsa-miR-361-3p PRRX1 -0.126462931388735 0.566052688733137 1.07480943364119 0.0439401613521789 PITA -0.695915151768153 6.70571026260252e-05 NA NA NA hsa-miR-486-5p PRRX1 -0.627607241830911 0.155274583521138 1.07480943364119 0.0439401613521789 miRanda -0.252766801015425 0.00333237474481359 NA NA NA hsa-miR-500a-5p PRRX1 0.00337014556047865 0.992120109131868 1.07480943364119 0.0439401613521789 mirMAP -0.55123282738372 5.20693567418651e-07 NA NA NA hsa-miR-550a-3p PRRX1 2.05849884025997 7.99642185793604e-07 1.07480943364119 0.0439401613521789 miRNATAP -0.339723274490867 0.000508209115096032 NA NA NA hsa-miR-616-5p PRRX1 0.834052908652744 0.0347835664029363 1.07480943364119 0.0439401613521789 mirMAP -0.293313792384813 0.00273862139684743 NA NA NA hsa-miR-7-1-3p PRRX1 0.709309110750947 0.0412301737463194 1.07480943364119 0.0439401613521789 mirMAP -0.671183161054977 1.74344215740006e-10 NA NA NA hsa-miR-107 PTHLH 0.904627575346218 4.67936495073904e-05 1.36630706781914 0.197869492491983 miRanda -1.52106192668855 5.27672707595945e-06 NA NA NA hsa-miR-126-5p PTHLH 0.41765430251855 0.0753161203651532 1.36630706781914 0.197869492491983 mirMAP -1.08015638516986 0.000885362031831404 NA NA NA hsa-miR-139-5p PTHLH -1.83374360776637 1.22019901002824e-09 1.36630706781914 0.197869492491983 miRanda -0.730205983631035 0.00241553982561914 NA NA NA hsa-miR-190a-5p PTHLH -0.735154513525545 0.0662435769685494 1.36630706781914 0.197869492491983 MirTarget -0.992794760310896 6.94168605263557e-08 NA NA NA hsa-miR-200b-3p PTHLH 0.974577911407732 0.0595020056914543 1.36630706781914 0.197869492491983 MirTarget;TargetScan -0.659392287736399 4.04293711552799e-06 NA NA NA hsa-miR-29a-3p PTHLH -0.113012156986374 0.615005009685815 1.36630706781914 0.197869492491983 MirTarget -0.955772512418287 0.00532751435034292 NA NA NA hsa-miR-29b-3p PTHLH -0.230693226193598 0.367461626035234 1.36630706781914 0.197869492491983 MirTarget -1.20642086389816 4.53689546038555e-05 NA NA NA hsa-miR-29c-3p PTHLH -1.62454036584589 5.38376515586029e-07 1.36630706781914 0.197869492491983 MirTarget -0.662614871238102 0.00354944525108234 NA NA NA hsa-miR-429 PTHLH 1.40182602301928 0.00900426780286475 1.36630706781914 0.197869492491983 MirTarget;PITA;miRanda -0.515466624505505 0.000198716680115915 NA NA NA hsa-miR-592 PTHLH 0.779567202789068 0.204498177014474 1.36630706781914 0.197869492491983 PITA -0.820729009378766 8.03863916458484e-11 NA NA NA hsa-miR-188-5p PTX3 1.35426907033843 0.00038346077691455 -2.63752083438205 4.49747630240384e-05 PITA -0.548381447710462 4.45493106970188e-06 NA NA NA hsa-miR-330-5p PTX3 0.488365986827708 0.0512207630808233 -2.63752083438205 4.49747630240384e-05 miRanda -0.504208858069831 0.00774945796427389 NA NA NA hsa-miR-7-1-3p PTX3 0.709309110750947 0.0412301737463194 -2.63752083438205 4.49747630240384e-05 mirMAP -0.433127324673739 0.00129371931740264 NA NA NA hsa-let-7b-5p PVR 0.0582902155815681 0.781400138984745 0.353746037960758 0.164133777433383 miRNAWalker2_validate -0.303240522100396 0.000522321086214849 NA NA NA hsa-miR-136-5p PVR -0.392356229753493 0.199261817142042 0.353746037960758 0.164133777433383 mirMAP -0.183977042124346 0.00190749615464345 NA NA NA hsa-miR-218-5p PVR -0.987730614742492 0.0108295837207062 0.353746037960758 0.164133777433383 mirMAP -0.224668374033218 7.25106637883883e-07 NA NA NA hsa-miR-34c-5p PVR 2.20632574870337 0.000379662996168678 0.353746037960758 0.164133777433383 miRanda -0.127440283284833 6.89440438709634e-06 NA NA NA hsa-miR-664a-3p PVR -0.83041219170254 0.000136267547251167 0.353746037960758 0.164133777433383 mirMAP -0.285124298485097 0.000557336097905057 NA NA NA hsa-miR-106a-5p QSOX1 -0.173255688252641 0.642872703263671 -1.18332308468766 0.000131981782245749 mirMAP -0.20736789488943 0.000519953059909822 NA NA NA hsa-miR-1271-5p QSOX1 1.15538250415776 0.00207865862606828 -1.18332308468766 0.000131981782245749 mirMAP -0.299766920036903 3.01398160643099e-07 NA NA NA hsa-miR-146b-5p QSOX1 1.547491371264 6.06614361290688e-08 -1.18332308468766 0.000131981782245749 miRanda -0.280781074642678 0.000202879944116725 NA NA NA hsa-miR-149-5p QSOX1 0.706277554734069 0.296848731347677 -1.18332308468766 0.000131981782245749 mirMAP -0.197617795515145 4.24992082283859e-10 NA NA NA hsa-miR-17-5p QSOX1 1.65862087862483 8.45603406215941e-08 -1.18332308468766 0.000131981782245749 mirMAP -0.248003148060899 0.000377136309482724 NA NA NA hsa-miR-193b-3p QSOX1 0.281752012268679 0.451258902263119 -1.18332308468766 0.000131981782245749 mirMAP -0.285389085620976 1.21090898459911e-06 NA NA NA hsa-miR-20a-5p QSOX1 1.4503375861709 5.7813456424762e-07 -1.18332308468766 0.000131981782245749 mirMAP -0.258630760567546 0.000561030957645583 NA NA NA hsa-miR-20b-5p QSOX1 -0.750137369661989 0.137699447213685 -1.18332308468766 0.000131981782245749 mirMAP -0.128970566399617 0.00354004567050376 NA NA NA hsa-miR-224-5p QSOX1 2.7648036144402 0.000111736336240167 -1.18332308468766 0.000131981782245749 mirMAP -0.208930263624113 5.16950469277639e-13 NA NA NA hsa-miR-23a-3p QSOX1 1.10685926969665 3.16223452471768e-08 -1.18332308468766 0.000131981782245749 mirMAP -0.542832859311888 4.63872386740346e-07 NA NA NA hsa-miR-24-3p QSOX1 1.08578167539644 6.18549359075268e-07 -1.18332308468766 0.000131981782245749 MirTarget;mirMAP -0.302479690192892 0.00283856442912591 NA NA NA hsa-miR-324-5p QSOX1 1.08820215809537 3.11674414561836e-05 -1.18332308468766 0.000131981782245749 mirMAP -0.346686134567914 3.50076447200165e-05 NA NA NA hsa-miR-331-3p QSOX1 1.04880525429426 9.99995355989124e-05 -1.18332308468766 0.000131981782245749 mirMAP -0.24720557733965 0.00263477368780132 NA NA NA hsa-miR-335-3p QSOX1 2.5197689063267 2.20084506976733e-09 -1.18332308468766 0.000131981782245749 mirMAP -0.139633524452789 0.0060656328666719 NA NA NA hsa-miR-342-3p QSOX1 0.318119432680668 0.269150960124243 -1.18332308468766 0.000131981782245749 mirMAP -0.32313833212279 2.96329065725582e-05 NA NA NA hsa-miR-342-5p QSOX1 0.692955062695486 0.030998736359949 -1.18332308468766 0.000131981782245749 mirMAP -0.307972593894833 7.13854770557282e-06 NA NA NA hsa-miR-345-5p QSOX1 1.83686164833727 1.1036889735857e-08 -1.18332308468766 0.000131981782245749 mirMAP -0.218156225349921 0.00112236732723771 NA NA NA hsa-miR-34c-5p QSOX1 2.20632574870337 0.000379662996168678 -1.18332308468766 0.000131981782245749 mirMAP -0.232583793105764 7.44136205607103e-12 NA NA NA hsa-miR-374b-3p QSOX1 0.999491658196932 0.00126937019814872 -1.18332308468766 0.000131981782245749 mirMAP -0.330505702682509 1.04984209519224e-05 NA NA NA hsa-miR-452-5p QSOX1 2.08756506185889 0.000258095769002813 -1.18332308468766 0.000131981782245749 mirMAP -0.236704445346978 1.34571031112266e-10 NA NA NA hsa-miR-455-3p QSOX1 2.29532323519288 1.85675588946527e-07 -1.18332308468766 0.000131981782245749 mirMAP -0.144646701393681 0.00322203372397745 NA NA NA hsa-miR-508-3p QSOX1 0.903360437460794 0.210371484936862 -1.18332308468766 0.000131981782245749 mirMAP -0.101028391741201 0.00105677429268658 NA NA NA hsa-miR-629-3p QSOX1 1.40326397107309 9.7803063526732e-05 -1.18332308468766 0.000131981782245749 mirMAP -0.188441563702111 0.00202410740638567 NA NA NA hsa-miR-671-5p QSOX1 0.947458646379882 0.0024732430914236 -1.18332308468766 0.000131981782245749 mirMAP -0.273321462499466 0.000105571070404186 NA NA NA hsa-miR-744-3p QSOX1 1.40439584998788 0.000973603203532439 -1.18332308468766 0.000131981782245749 mirMAP -0.204669891879853 7.09155116197593e-05 NA NA NA hsa-miR-92a-3p QSOX1 1.2209325870225 6.8757197708107e-06 -1.18332308468766 0.000131981782245749 mirMAP -0.257474806165178 0.00147186948344265 NA NA NA hsa-miR-93-3p QSOX1 1.88964231421793 1.80075645722786e-08 -1.18332308468766 0.000131981782245749 mirMAP -0.221518910128959 0.000542626446649931 NA NA NA hsa-miR-93-5p QSOX1 1.7515174434778 1.59386482413883e-08 -1.18332308468766 0.000131981782245749 mirMAP -0.311657741555658 5.6977839847522e-06 NA NA NA hsa-miR-107 RGS4 0.904627575346218 4.67936495073904e-05 -0.395650649571247 0.457180781353428 MirTarget;miRanda;miRNATAP -0.570646172984556 0.000743103827351658 NA NA NA hsa-miR-126-5p RGS4 0.41765430251855 0.0753161203651532 -0.395650649571247 0.457180781353428 MirTarget;mirMAP -0.805294302126631 4.52755398616583e-07 NA NA NA hsa-miR-16-2-3p RGS4 1.8048179609245 2.83095715136409e-09 -0.395650649571247 0.457180781353428 MirTarget;mirMAP -0.424725912726539 0.000371556231733569 NA NA NA hsa-miR-26b-5p RGS4 -0.301646326928219 0.160081421968103 -0.395650649571247 0.457180781353428 MirTarget;miRNATAP -0.641939244391318 0.000320834491001536 NA NA NA hsa-miR-29b-1-5p RGS4 0.606560155953522 0.116355599574769 -0.395650649571247 0.457180781353428 MirTarget -0.466140667300607 1.29742647831446e-06 NA NA NA hsa-miR-30b-3p RGS4 -0.266398938200332 0.400847813143994 -0.395650649571247 0.457180781353428 MirTarget -0.644355018599901 3.33192954601319e-08 NA NA NA hsa-miR-330-5p RGS4 0.488365986827708 0.0512207630808233 -0.395650649571247 0.457180781353428 miRanda -0.538359502163484 0.00038271499562676 NA NA NA hsa-miR-338-5p RGS4 -1.19659203838734 0.0100316010080496 -0.395650649571247 0.457180781353428 MirTarget;PITA -0.312490796620729 9.46672767259327e-05 NA NA NA hsa-miR-590-3p RGS4 1.11654983899947 0.000160782154924864 -0.395650649571247 0.457180781353428 mirMAP -0.480177136379346 0.000131900491788107 NA NA NA hsa-miR-616-5p RGS4 0.834052908652744 0.0347835664029363 -0.395650649571247 0.457180781353428 MirTarget;mirMAP -0.321918740509914 0.000900963333612669 NA NA NA hsa-miR-146b-5p RHOB 1.547491371264 6.06614361290688e-08 -1.18375957833144 0.000150297671651682 miRanda -0.236610280335257 0.00202030553019967 NA NA NA hsa-miR-183-5p RHOB 1.65900927871187 0.000522025364980187 -1.18375957833144 0.000150297671651682 miRNATAP -0.164446229592721 0.00037133907729746 NA NA NA hsa-miR-19a-3p RHOB 1.26669687448473 0.000105972838514412 -1.18375957833144 0.000150297671651682 MirTarget;miRNATAP -0.258615897594745 0.000129468434395293 26041879 Ras homolog family member B RHOB was identified as a direct target of miR-19a pancreatic cancer hsa-miR-19b-3p RHOB 0.759818275708988 0.00652779573186786 -1.18375957833144 0.000150297671651682 MirTarget;miRNATAP -0.305949989123494 0.000134941536006134 NA NA NA hsa-miR-21-5p RHOB 1.75445050487988 2.41825549682022e-23 -1.18375957833144 0.000150297671651682 miRNAWalker2_validate;miRTarBase;miRNATAP -0.345238731513622 0.00300403940759588 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-30d-5p RHOB -0.5492586056147 0.0140125082460125 -1.18375957833144 0.000150297671651682 miRNATAP -0.281696748236962 0.00580147958615137 NA NA NA hsa-miR-330-3p RHOB 0.798460296022179 0.00746538156533435 -1.18375957833144 0.000150297671651682 MirTarget;miRNATAP -0.241450119421827 0.00134638879082905 NA NA NA hsa-miR-335-5p RHOB 1.59953351087307 5.56170899867314e-05 -1.18375957833144 0.000150297671651682 miRNAWalker2_validate -0.24919083192373 5.74314078513319e-06 NA NA NA hsa-miR-3662 RHOB 1.82780708047676 0.0054036501346178 -1.18375957833144 0.000150297671651682 mirMAP -0.11739723860516 0.00771275117171575 NA NA NA hsa-miR-429 RHOB 1.40182602301928 0.00900426780286475 -1.18375957833144 0.000150297671651682 miRNATAP -0.189022380302869 3.88377330878047e-06 NA NA NA hsa-miR-629-3p RHOB 1.40326397107309 9.7803063526732e-05 -1.18375957833144 0.000150297671651682 mirMAP -0.162912894740733 0.00836406473923405 NA NA NA hsa-miR-642a-5p RHOB -0.626411225079539 0.175275421929086 -1.18375957833144 0.000150297671651682 MirTarget -0.15938525296493 0.00213206708952135 NA NA NA hsa-miR-939-5p RHOB 0.857156740351386 0.0124815824643173 -1.18375957833144 0.000150297671651682 MirTarget -0.201364001598206 0.00518546666361591 NA NA NA hsa-miR-9-3p SAT1 0.330346058941473 0.541111939982661 0.109750765913575 0.711006077076015 MirTarget;miRNATAP -0.113490088288367 0.00506810073133873 NA NA NA hsa-miR-30b-3p SCG2 -0.266398938200332 0.400847813143994 -1.28891088431876 0.0369272536769038 MirTarget -0.414752736719932 0.00304216224769885 NA NA NA hsa-miR-452-3p SCG2 2.2028815467959 0.00185370432491004 -1.28891088431876 0.0369272536769038 MirTarget -0.290001395135467 2.36128162182686e-05 NA NA NA hsa-miR-486-5p SCG2 -0.627607241830911 0.155274583521138 -1.28891088431876 0.0369272536769038 miRanda;miRNATAP -0.269163705405643 0.0070803746025143 NA NA NA hsa-miR-590-3p SCG2 1.11654983899947 0.000160782154924864 -1.28891088431876 0.0369272536769038 miRanda -0.569623365126524 0.000100556217514828 NA NA NA hsa-miR-10a-5p SDC1 -0.470861534765518 0.148803248989189 2.10051799870315 8.18085874737965e-06 MirTarget;miRNATAP -0.562932439486576 4.18860920413166e-08 NA NA NA hsa-miR-125a-5p SDC1 -0.878090699011564 0.000213630844319685 2.10051799870315 8.18085874737965e-06 mirMAP -0.441948224351207 0.00218064295061606 NA NA NA hsa-miR-338-3p SDC1 -0.959276231066179 0.0191473351014091 2.10051799870315 8.18085874737965e-06 miRanda -0.511751907886456 1.57288652790044e-10 NA NA NA hsa-miR-375 SDC1 -2.94506033785642 0.00570147601654791 2.10051799870315 8.18085874737965e-06 miRNAWalker2_validate -0.161577841361136 1.89043187193393e-07 NA NA NA hsa-miR-491-5p SDC1 -0.693578126269305 0.0313646742330058 2.10051799870315 8.18085874737965e-06 miRanda -0.356309618171978 0.00103142880399656 NA NA NA hsa-miR-660-5p SDC1 -0.0206552819434673 0.938868734063643 2.10051799870315 8.18085874737965e-06 MirTarget;miRNATAP -0.698262033947668 2.41696990164501e-08 NA NA NA hsa-miR-129-5p SERPINE1 -2.56914016541176 2.36237896095709e-06 0.873189054905582 0.11255072331134 miRanda -0.19644165437006 0.00589849447253088 NA NA NA hsa-miR-148a-3p SERPINE1 -1.53721533763578 3.55533747293117e-05 0.873189054905582 0.11255072331134 miRNATAP -0.436559131161047 1.9709933577873e-05 NA NA NA hsa-miR-148a-5p SERPINE1 -0.69329616490858 0.0793012233740369 0.873189054905582 0.11255072331134 miRNATAP -0.527300729477906 4.57253053812486e-08 NA NA NA hsa-miR-2110 SERPINE1 0.759864042760204 0.0723961390557655 0.873189054905582 0.11255072331134 miRNATAP -0.330642930294297 0.000392739120335177 NA NA NA hsa-miR-30b-5p SERPINE1 -0.430720743745757 0.0593564057320791 0.873189054905582 0.11255072331134 MirTarget -0.723431021861993 2.57885394455558e-05 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -0.983130268805942 4.60419218706127e-05 0.873189054905582 0.11255072331134 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.480138224039187 0.00294414713695789 NA NA NA hsa-miR-30d-5p SERPINE1 -0.5492586056147 0.0140125082460125 0.873189054905582 0.11255072331134 miRNATAP -0.997455560362319 6.34120387227326e-09 NA NA NA hsa-miR-378a-5p SERPINE1 -0.557166502179376 0.0344581590006454 0.873189054905582 0.11255072331134 MirTarget -0.612665935436298 3.5388157525321e-05 NA NA NA hsa-miR-769-5p SERPINE1 1.14821899306381 1.27143750879772e-06 0.873189054905582 0.11255072331134 MirTarget;miRNATAP -0.506471309568269 0.0018700765705002 NA NA NA hsa-miR-186-5p SERPINE2 0.149964130725901 0.434709542998771 0.830584061118028 0.129277476094315 MirTarget -0.668217143549836 0.00133620366793142 NA NA NA hsa-miR-222-5p SERPINE2 1.87968474330782 1.11743009485711e-06 0.830584061118028 0.129277476094315 MirTarget -0.283251055108011 0.00398492610636656 NA NA NA hsa-miR-335-3p SERPINE2 2.5197689063267 2.20084506976733e-09 0.830584061118028 0.129277476094315 MirTarget -0.296845255547815 0.000779759701546965 NA NA NA hsa-miR-429 SERPINE2 1.40182602301928 0.00900426780286475 0.830584061118028 0.129277476094315 miRanda -0.413993048623284 2.65717542704998e-09 NA NA NA hsa-miR-625-5p SERPINE2 0.537211086526376 0.203801009380384 0.830584061118028 0.129277476094315 MirTarget -0.540810155311349 1.50943679370467e-09 NA NA NA hsa-miR-29a-3p SERPINH1 -0.113012156986374 0.615005009685815 1.68692204088516 7.50337147791603e-08 miRNATAP -0.30184770685988 0.00390652084959821 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA 29a in lung cancer with idiopathic pulmonary fibrosis; Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF suggesting that these genes are involved in the pathogenesis of these two diseases.Journal of Human Genetics advance online publication 4 August 2016; doi:10.1038/jhg.2016.99 staging lung cancer hsa-miR-29c-3p SERPINH1 -1.62454036584589 5.38376515586029e-07 1.68692204088516 7.50337147791603e-08 miRNATAP -0.440271228722389 3.10919709628914e-11 NA NA NA hsa-miR-3065-3p SERPINH1 -1.03551124329864 0.0218397494946288 1.68692204088516 7.50337147791603e-08 miRNATAP -0.13681099470311 0.00715694408542843 NA NA NA hsa-miR-1301-3p SFRP1 1.59017279464031 4.6624715470094e-06 -3.73671219416013 0.000115942934695214 MirTarget -0.520003651041563 0.00872324860632008 NA NA NA hsa-miR-16-1-3p SFRP1 1.43227522002564 3.70920454953168e-08 -3.73671219416013 0.000115942934695214 MirTarget -0.698288753089572 0.00800627664394367 NA NA NA hsa-miR-192-3p SFRP1 0.355565421687399 0.74117031340037 -3.73671219416013 0.000115942934695214 MirTarget -0.420171666764993 2.78408891525019e-11 NA NA NA hsa-miR-19b-1-5p SFRP1 1.38738648038895 1.3113681938066e-06 -3.73671219416013 0.000115942934695214 MirTarget -0.984684046956697 3.30966927911474e-05 NA NA NA hsa-miR-29a-5p SFRP1 0.585084040404152 0.023014129158495 -3.73671219416013 0.000115942934695214 mirMAP -1.18233050028483 1.27334112028818e-05 NA NA NA hsa-miR-335-5p SFRP1 1.59953351087307 5.56170899867314e-05 -3.73671219416013 0.000115942934695214 miRNAWalker2_validate -0.640270191287217 0.000207785991396882 NA NA NA hsa-miR-33a-3p SFRP1 0.347011402017138 0.321709379745392 -3.73671219416013 0.000115942934695214 MirTarget -0.713178926422237 0.000726797091828663 NA NA NA hsa-miR-429 SFRP1 1.40182602301928 0.00900426780286475 -3.73671219416013 0.000115942934695214 miRNATAP -0.673316837627797 9.88143165829959e-08 NA NA NA hsa-miR-501-5p SFRP1 0.266919328110625 0.454779001968586 -3.73671219416013 0.000115942934695214 mirMAP -0.760737167981301 0.00010143822971021 NA NA NA hsa-miR-625-5p SFRP1 0.537211086526376 0.203801009380384 -3.73671219416013 0.000115942934695214 MirTarget -0.905317189235985 2.38826076026379e-08 NA NA NA hsa-miR-7-1-3p SFRP1 0.709309110750947 0.0412301737463194 -3.73671219416013 0.000115942934695214 MirTarget;mirMAP -1.10073280964163 2.00476689478305e-08 NA NA NA hsa-miR-135b-5p SFRP4 4.09156383496059 1.32294295002438e-12 1.03593777968637 0.301808686879172 MirTarget -0.351743816143704 0.00242349896328834 NA NA NA hsa-miR-144-5p SFRP4 -0.644861505244731 0.173474442191587 1.03593777968637 0.301808686879172 MirTarget -0.942504036080998 5.94318618018826e-11 NA NA NA hsa-miR-26b-5p SFRP4 -0.301646326928219 0.160081421968103 1.03593777968637 0.301808686879172 miRNAWalker2_validate -1.30446811923916 0.000103154998198992 NA NA NA hsa-miR-375 SFRP4 -2.94506033785642 0.00570147601654791 1.03593777968637 0.301808686879172 miRanda -0.254847928580947 0.000101634332290762 NA NA NA hsa-miR-429 SFRP4 1.40182602301928 0.00900426780286475 1.03593777968637 0.301808686879172 miRanda -0.522715548330698 6.20618740653898e-05 NA NA NA hsa-miR-532-5p SFRP4 0.313080805824184 0.252248939356301 1.03593777968637 0.301808686879172 MirTarget -1.13621123480396 1.24412354962375e-05 NA NA NA hsa-miR-16-2-3p SGCB 1.8048179609245 2.83095715136409e-09 -0.812300925658533 0.00288877708696444 mirMAP -0.286845726226301 2.44105705770664e-06 NA NA NA hsa-miR-182-5p SGCB 0.887369486030646 0.0310640781418789 -0.812300925658533 0.00288877708696444 mirMAP -0.17196418663318 0.000251364838615858 NA NA NA hsa-miR-32-3p SGCB 0.583525764322974 0.11837203008551 -0.812300925658533 0.00288877708696444 mirMAP -0.219240826366551 0.00017662092122693 24348862 microRNA 32 inhibits the proliferation and invasion of the SGC 7901 gastric cancer cell line in vitro gastric cancer hsa-miR-32-5p SGCB 0.415247682945382 0.106458022460373 -0.812300925658533 0.00288877708696444 mirMAP -0.339559873913139 6.91590248212709e-06 24348862 microRNA 32 inhibits the proliferation and invasion of the SGC 7901 gastric cancer cell line in vitro gastric cancer hsa-miR-330-5p SGCB 0.488365986827708 0.0512207630808233 -0.812300925658533 0.00288877708696444 miRanda -0.218682633253988 0.00549425881554507 NA NA NA hsa-miR-335-3p SGCB 2.5197689063267 2.20084506976733e-09 -0.812300925658533 0.00288877708696444 mirMAP -0.147449632491162 0.000860460553553504 NA NA NA hsa-miR-429 SGCB 1.40182602301928 0.00900426780286475 -0.812300925658533 0.00288877708696444 miRanda;miRNATAP -0.126828295817782 0.000404703296267345 NA NA NA hsa-miR-590-3p SGCB 1.11654983899947 0.000160782154924864 -0.812300925658533 0.00288877708696444 miRNAWalker2_validate;miRanda;mirMAP -0.324218837585043 3.96953480142198e-07 NA NA NA hsa-let-7d-5p SGCD 0.981733854788227 7.26366577706469e-07 -1.8034519463366 0.000725657940585245 miRNATAP -0.999741827240489 1.04296056673636e-07 NA NA NA hsa-miR-103a-3p SGCD 0.840525139266028 5.83536475789158e-07 -1.8034519463366 0.000725657940585245 mirMAP -1.35733744854033 8.53470162357603e-10 NA NA NA hsa-miR-106a-5p SGCD -0.173255688252641 0.642872703263671 -1.8034519463366 0.000725657940585245 mirMAP -0.384781758845644 0.000174777382892343 NA NA NA hsa-miR-106b-5p SGCD 1.70863907461894 2.04074794107142e-08 -1.8034519463366 0.000725657940585245 mirMAP -0.839772416630331 3.66913519729906e-13 NA NA NA hsa-miR-107 SGCD 0.904627575346218 4.67936495073904e-05 -1.8034519463366 0.000725657940585245 mirMAP -0.963318263011009 8.53145867262793e-09 NA NA NA hsa-miR-130b-5p SGCD 0.701350393759937 0.0510142718395002 -1.8034519463366 0.000725657940585245 mirMAP -0.593310706785348 1.04856872577897e-08 NA NA NA hsa-miR-140-5p SGCD 0.208193069681326 0.303002433893804 -1.8034519463366 0.000725657940585245 PITA -0.613112645032531 0.00160953909164142 NA NA NA hsa-miR-142-5p SGCD 1.55592486377018 6.69269968016779e-06 -1.8034519463366 0.000725657940585245 miRNATAP -0.614465715445694 5.78924974529238e-09 NA NA NA hsa-miR-144-5p SGCD -0.644861505244731 0.173474442191587 -1.8034519463366 0.000725657940585245 mirMAP -0.331058505608599 3.59992114332853e-05 NA NA NA hsa-miR-146a-5p SGCD 1.82051649415508 2.03651725047679e-05 -1.8034519463366 0.000725657940585245 mirMAP -0.397495027625866 4.53450689341087e-06 NA NA NA hsa-miR-148a-5p SGCD -0.69329616490858 0.0793012233740369 -1.8034519463366 0.000725657940585245 mirMAP -0.426283240282676 8.63009423628819e-06 NA NA NA hsa-miR-148b-5p SGCD 1.04409494910362 0.00195860954157389 -1.8034519463366 0.000725657940585245 mirMAP -0.604177367500429 4.19695453692528e-08 NA NA NA hsa-miR-15a-5p SGCD 1.03783090449383 7.40334108980898e-07 -1.8034519463366 0.000725657940585245 miRNATAP -1.06101705384931 1.41013739045961e-09 NA NA NA hsa-miR-15b-5p SGCD 1.62046407540723 5.42152621571078e-09 -1.8034519463366 0.000725657940585245 miRNATAP -0.928099240329595 2.1569968881069e-13 NA NA NA hsa-miR-16-2-3p SGCD 1.8048179609245 2.83095715136409e-09 -1.8034519463366 0.000725657940585245 mirMAP -0.855435714966678 1.0032433773743e-13 NA NA NA hsa-miR-16-5p SGCD 1.00515772948091 5.33912942007619e-06 -1.8034519463366 0.000725657940585245 miRNATAP -1.46040953521159 1.20790527668322e-20 NA NA NA hsa-miR-17-5p SGCD 1.65862087862483 8.45603406215941e-08 -1.8034519463366 0.000725657940585245 mirMAP -0.755063475499021 6.25756087791677e-11 NA NA NA hsa-miR-19a-3p SGCD 1.26669687448473 0.000105972838514412 -1.8034519463366 0.000725657940585245 mirMAP -0.650523752948786 7.42601889397148e-09 NA NA NA hsa-miR-19b-3p SGCD 0.759818275708988 0.00652779573186786 -1.8034519463366 0.000725657940585245 mirMAP -0.766007790678849 9.72024830520128e-09 NA NA NA hsa-miR-200b-3p SGCD 0.974577911407732 0.0595020056914543 -1.8034519463366 0.000725657940585245 mirMAP -0.310195850647249 2.19772314450785e-05 NA NA NA hsa-miR-200c-3p SGCD 1.28185685499076 0.00369777635539177 -1.8034519463366 0.000725657940585245 mirMAP -0.462753907646339 3.44645988253425e-08 NA NA NA hsa-miR-20a-5p SGCD 1.4503375861709 5.7813456424762e-07 -1.8034519463366 0.000725657940585245 mirMAP -0.735185106216139 4.46068929869908e-09 NA NA NA hsa-miR-21-3p SGCD 1.75245546017565 2.36505176715025e-10 -1.8034519463366 0.000725657940585245 mirMAP -0.59865006870283 5.21332808141666e-06 NA NA NA hsa-miR-212-3p SGCD 0.960352937108106 0.00133449812322732 -1.8034519463366 0.000725657940585245 mirMAP -0.444666018271387 0.000492281094934101 NA NA NA hsa-miR-23a-3p SGCD 1.10685926969665 3.16223452471768e-08 -1.8034519463366 0.000725657940585245 mirMAP -0.54002374132719 0.0043557271022226 NA NA NA hsa-miR-25-3p SGCD 1.00604871526544 0.000421838061147906 -1.8034519463366 0.000725657940585245 mirMAP -0.679305992854148 2.06607466940528e-07 NA NA NA hsa-miR-26b-5p SGCD -0.301646326928219 0.160081421968103 -1.8034519463366 0.000725657940585245 miRNATAP -0.826337873417551 4.16341735684611e-06 NA NA NA hsa-miR-29a-5p SGCD 0.585084040404152 0.023014129158495 -1.8034519463366 0.000725657940585245 mirMAP -0.657840867876356 9.08122168427899e-06 NA NA NA hsa-miR-29b-1-5p SGCD 0.606560155953522 0.116355599574769 -1.8034519463366 0.000725657940585245 mirMAP -0.484923097081012 7.07764251422073e-07 NA NA NA hsa-miR-32-3p SGCD 0.583525764322974 0.11837203008551 -1.8034519463366 0.000725657940585245 mirMAP -0.65042098705427 6.97547242948302e-09 NA NA NA hsa-miR-32-5p SGCD 0.415247682945382 0.106458022460373 -1.8034519463366 0.000725657940585245 mirMAP -0.720743035813608 1.12860709146607e-06 NA NA NA hsa-miR-331-5p SGCD 1.0778596491846 2.79470024753813e-05 -1.8034519463366 0.000725657940585245 mirMAP -0.570728550260854 0.00010102821530134 NA NA NA hsa-miR-335-3p SGCD 2.5197689063267 2.20084506976733e-09 -1.8034519463366 0.000725657940585245 mirMAP -0.468145779396355 3.66637146288036e-08 NA NA NA hsa-miR-335-5p SGCD 1.59953351087307 5.56170899867314e-05 -1.8034519463366 0.000725657940585245 miRNAWalker2_validate;miRNATAP -0.487761801775095 1.50722386459343e-07 NA NA NA hsa-miR-339-5p SGCD 0.770566566962108 0.00816529093411862 -1.8034519463366 0.000725657940585245 PITA;miRNATAP -0.738033391051939 7.93770302996141e-09 NA NA NA hsa-miR-33a-3p SGCD 0.347011402017138 0.321709379745392 -1.8034519463366 0.000725657940585245 mirMAP -0.645656454712748 9.36886613779865e-09 NA NA NA hsa-miR-33a-5p SGCD 0.407757858040717 0.321429014317207 -1.8034519463366 0.000725657940585245 mirMAP;miRNATAP -0.574446880584062 1.59811838166502e-10 NA NA NA hsa-miR-33b-5p SGCD 0.267227362818466 0.614814331176942 -1.8034519463366 0.000725657940585245 mirMAP;miRNATAP -0.346302340207963 0.000199429212435555 NA NA NA hsa-miR-3607-3p SGCD 0.522750552658156 0.0842510989344654 -1.8034519463366 0.000725657940585245 mirMAP -0.35654135114821 0.0052275160496348 NA NA NA hsa-miR-361-5p SGCD 0.407725414130987 0.0181260969156347 -1.8034519463366 0.000725657940585245 miRNATAP -0.745445050546193 0.00111645552225037 NA NA NA hsa-miR-362-3p SGCD -0.0349414695893027 0.913780708043777 -1.8034519463366 0.000725657940585245 miRNATAP -0.4144299942733 0.000537847019484879 NA NA NA hsa-miR-3682-3p SGCD 1.96838261925327 4.94885331227292e-06 -1.8034519463366 0.000725657940585245 mirMAP -0.589649653212557 3.95811686982015e-09 NA NA NA hsa-miR-424-5p SGCD 1.08509868581983 0.000420473853818268 -1.8034519463366 0.000725657940585245 miRNATAP -0.46054991651245 0.000182676041327232 NA NA NA hsa-miR-429 SGCD 1.40182602301928 0.00900426780286475 -1.8034519463366 0.000725657940585245 mirMAP -0.352000860411048 3.98713914969059e-07 NA NA NA hsa-miR-486-5p SGCD -0.627607241830911 0.155274583521138 -1.8034519463366 0.000725657940585245 miRanda -0.323171433478373 0.000182039692466133 NA NA NA hsa-miR-500a-5p SGCD 0.00337014556047865 0.992120109131868 -1.8034519463366 0.000725657940585245 mirMAP -0.323864073638995 0.00427322537012476 NA NA NA hsa-miR-532-5p SGCD 0.313080805824184 0.252248939356301 -1.8034519463366 0.000725657940585245 PITA -0.643200873417841 4.11651474632857e-06 NA NA NA hsa-miR-576-5p SGCD 0.625714137488957 0.0417100301848969 -1.8034519463366 0.000725657940585245 mirMAP -0.679550411812963 2.47237571211715e-08 NA NA NA hsa-miR-577 SGCD 0.911619788986754 0.2256062124148 -1.8034519463366 0.000725657940585245 PITA;miRNATAP -0.261923086323206 2.77624134577724e-07 NA NA NA hsa-miR-582-3p SGCD -0.412897415951272 0.202939245403793 -1.8034519463366 0.000725657940585245 mirMAP -0.360820344806386 0.00242751197810493 NA NA NA hsa-miR-589-3p SGCD 1.01962606923682 0.00577853347252709 -1.8034519463366 0.000725657940585245 mirMAP -0.400878369047832 9.31623797895494e-05 NA NA NA hsa-miR-590-3p SGCD 1.11654983899947 0.000160782154924864 -1.8034519463366 0.000725657940585245 PITA;miRanda;mirMAP;miRNATAP -0.733611230415393 3.79948402684302e-09 NA NA NA hsa-miR-590-5p SGCD 1.04171442093217 0.000272475544954865 -1.8034519463366 0.000725657940585245 miRanda -0.919886936107091 2.91344881796571e-13 NA NA NA hsa-miR-616-5p SGCD 0.834052908652744 0.0347835664029363 -1.8034519463366 0.000725657940585245 miRNATAP -0.413112339082128 2.37203817634636e-05 NA NA NA hsa-miR-625-3p SGCD -0.185298294014366 0.626215541224408 -1.8034519463366 0.000725657940585245 mirMAP -0.46592479354819 2.94347148079332e-06 NA NA NA hsa-miR-628-3p SGCD -0.740114422664914 0.0733161778062279 -1.8034519463366 0.000725657940585245 PITA;miRNATAP -0.307166683581583 0.00110371408664502 NA NA NA hsa-miR-7-1-3p SGCD 0.709309110750947 0.0412301737463194 -1.8034519463366 0.000725657940585245 mirMAP -0.556445473052306 2.64346306338549e-07 NA NA NA hsa-miR-92a-3p SGCD 1.2209325870225 6.8757197708107e-06 -1.8034519463366 0.000725657940585245 mirMAP -0.994732591555175 3.41179527159117e-14 NA NA NA hsa-miR-93-5p SGCD 1.7515174434778 1.59386482413883e-08 -1.8034519463366 0.000725657940585245 mirMAP -0.580315994907508 8.02588528132531e-07 NA NA NA hsa-miR-126-5p SLIT2 0.41765430251855 0.0753161203651532 -3.22418217949118 8.0309413703175e-05 mirMAP -0.978475288489917 0.000113599048180679 NA NA NA hsa-miR-200b-3p SLIT2 0.974577911407732 0.0595020056914543 -3.22418217949118 8.0309413703175e-05 TargetScan -0.800017472598438 9.77362099208671e-14 NA NA NA hsa-miR-26b-3p SLIT2 -0.0103961389461977 0.965770899625511 -3.22418217949118 8.0309413703175e-05 miRNATAP -1.17807848014614 1.34998633061487e-06 NA NA NA hsa-miR-3065-5p SLIT2 -0.241623656423063 0.633116553078159 -3.22418217949118 8.0309413703175e-05 mirMAP -0.366860699099007 0.00220636617148321 NA NA NA hsa-miR-330-3p SLIT2 0.798460296022179 0.00746538156533435 -3.22418217949118 8.0309413703175e-05 miRNAWalker2_validate -0.776535995909891 7.83922201592e-05 NA NA NA hsa-miR-338-5p SLIT2 -1.19659203838734 0.0100316010080496 -3.22418217949118 8.0309413703175e-05 PITA;miRNATAP -0.406446761110474 0.00128214806964047 NA NA NA hsa-miR-576-5p SLIT2 0.625714137488957 0.0417100301848969 -3.22418217949118 8.0309413703175e-05 mirMAP -0.968874377910946 2.95279159387793e-07 NA NA NA hsa-miR-590-3p SLIT2 1.11654983899947 0.000160782154924864 -3.22418217949118 8.0309413703175e-05 miRanda -1.06223709639412 3.680094563875e-08 NA NA NA hsa-miR-130b-3p SLIT3 1.32714007211004 4.78676252285191e-05 -2.27087535864765 2.24270034452098e-06 mirMAP -0.518871634791879 5.53921975193181e-07 NA NA NA hsa-miR-130b-5p SLIT3 0.701350393759937 0.0510142718395002 -2.27087535864765 2.24270034452098e-06 mirMAP -0.400999636575715 3.20733864121481e-05 NA NA NA hsa-miR-135b-5p SLIT3 4.09156383496059 1.32294295002438e-12 -2.27087535864765 2.24270034452098e-06 mirMAP -0.316514762140052 1.03228205311246e-08 NA NA NA hsa-miR-148b-5p SLIT3 1.04409494910362 0.00195860954157389 -2.27087535864765 2.24270034452098e-06 mirMAP -0.464548209982296 4.91971609476465e-06 NA NA NA hsa-miR-16-2-3p SLIT3 1.8048179609245 2.83095715136409e-09 -2.27087535864765 2.24270034452098e-06 mirMAP -0.584658371816275 6.836247751454e-08 NA NA NA hsa-miR-188-5p SLIT3 1.35426907033843 0.00038346077691455 -2.27087535864765 2.24270034452098e-06 mirMAP -0.425236181002556 1.84621502909596e-06 NA NA NA hsa-miR-1976 SLIT3 0.923172654386147 0.000118514313506673 -2.27087535864765 2.24270034452098e-06 mirMAP -0.656747259032298 4.67388916738944e-06 NA NA NA hsa-miR-200c-5p SLIT3 0.840328528720891 0.0574610665063827 -2.27087535864765 2.24270034452098e-06 mirMAP -0.339891798980647 8.84637211767236e-05 NA NA NA hsa-miR-224-3p SLIT3 1.52422171450716 0.00650463542340912 -2.27087535864765 2.24270034452098e-06 mirMAP -0.210122668920797 0.00196093762017894 NA NA NA hsa-miR-301a-3p SLIT3 1.44721900431161 6.35068481036652e-06 -2.27087535864765 2.24270034452098e-06 mirMAP -0.423325772139396 6.8121385332397e-05 NA NA NA hsa-miR-330-3p SLIT3 0.798460296022179 0.00746538156533435 -2.27087535864765 2.24270034452098e-06 mirMAP -0.525877130675448 5.39530685148573e-06 NA NA NA hsa-miR-330-5p SLIT3 0.488365986827708 0.0512207630808233 -2.27087535864765 2.24270034452098e-06 miRanda;mirMAP -0.632068368051697 5.55041157417888e-06 NA NA NA hsa-miR-335-3p SLIT3 2.5197689063267 2.20084506976733e-09 -2.27087535864765 2.24270034452098e-06 mirMAP -0.429803678931157 2.92665194233943e-08 NA NA NA hsa-miR-33a-3p SLIT3 0.347011402017138 0.321709379745392 -2.27087535864765 2.24270034452098e-06 mirMAP -0.375058453365 0.000365518545677265 NA NA NA hsa-miR-3662 SLIT3 1.82780708047676 0.0054036501346178 -2.27087535864765 2.24270034452098e-06 MirTarget;mirMAP -0.182090299696327 0.00789769562977714 NA NA NA hsa-miR-3682-3p SLIT3 1.96838261925327 4.94885331227292e-06 -2.27087535864765 2.24270034452098e-06 mirMAP -0.376190841336527 5.77623842828827e-05 NA NA NA hsa-miR-429 SLIT3 1.40182602301928 0.00900426780286475 -2.27087535864765 2.24270034452098e-06 miRNATAP -0.349017043804562 2.90943801947402e-08 NA NA NA hsa-miR-454-3p SLIT3 0.625199142970745 0.0134890997402741 -2.27087535864765 2.24270034452098e-06 mirMAP -0.378109803401563 0.00676690752485765 NA NA NA hsa-miR-500a-5p SLIT3 0.00337014556047865 0.992120109131868 -2.27087535864765 2.24270034452098e-06 mirMAP -0.327004921670236 0.00151982950284916 NA NA NA hsa-miR-550a-3p SLIT3 2.05849884025997 7.99642185793604e-07 -2.27087535864765 2.24270034452098e-06 mirMAP -0.442536540505528 5.75386584577528e-07 NA NA NA hsa-miR-577 SLIT3 0.911619788986754 0.2256062124148 -2.27087535864765 2.24270034452098e-06 MirTarget -0.198650693610587 2.37481695437715e-05 NA NA NA hsa-miR-589-3p SLIT3 1.01962606923682 0.00577853347252709 -2.27087535864765 2.24270034452098e-06 mirMAP -0.337019321025061 0.000329318874193468 NA NA NA hsa-miR-590-3p SLIT3 1.11654983899947 0.000160782154924864 -2.27087535864765 2.24270034452098e-06 miRanda;mirMAP -0.487528772643405 2.6503754879203e-05 NA NA NA hsa-miR-590-5p SLIT3 1.04171442093217 0.000272475544954865 -2.27087535864765 2.24270034452098e-06 miRanda -0.682476996699571 6.94271489806894e-09 NA NA NA hsa-miR-616-5p SLIT3 0.834052908652744 0.0347835664029363 -2.27087535864765 2.24270034452098e-06 mirMAP -0.248062422006285 0.00603193325660624 NA NA NA hsa-miR-625-5p SLIT3 0.537211086526376 0.203801009380384 -2.27087535864765 2.24270034452098e-06 mirMAP -0.2824309898603 0.000674079306374665 NA NA NA hsa-miR-940 SLIT3 1.64406174271686 0.000690854900107004 -2.27087535864765 2.24270034452098e-06 MirTarget -0.387662820554586 3.03338638046928e-06 NA NA NA hsa-miR-96-5p SLIT3 1.14243043653372 0.00942969392739105 -2.27087535864765 2.24270034452098e-06 TargetScan -0.402056224977592 7.71577957234073e-07 NA NA NA hsa-miR-107 SNAI2 0.904627575346218 4.67936495073904e-05 0.8679564879757 0.163674726451342 miRanda -0.956073669477844 9.87262308538113e-07 NA NA NA hsa-miR-126-5p SNAI2 0.41765430251855 0.0753161203651532 0.8679564879757 0.163674726451342 MirTarget -0.698491882102722 0.000239984015988638 NA NA NA hsa-miR-140-5p SNAI2 0.208193069681326 0.303002433893804 0.8679564879757 0.163674726451342 miRanda -0.709926892739581 0.00155086520600903 25322669;27597739 Down regulation of miR 140 induces EMT and promotes invasion by targeting Slug in esophageal cancer; Slug a target gene of miR-140 was examined by luciferase assay and Western blot; miR-140 may regulate the cell invasion of EC via controlling Slug expression;Mechanistically Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA ceRNA for miR-140-5p to de-repress the expression of the target gene Slug ; esophageal cancer;liver cancer hsa-miR-148b-3p SNAI2 0.295175884456199 0.17466422420702 0.8679564879757 0.163674726451342 miRNAWalker2_validate -0.880275520162378 1.78722551968974e-05 NA NA NA hsa-miR-200b-3p SNAI2 0.974577911407732 0.0595020056914543 0.8679564879757 0.163674726451342 TargetScan -0.481058558788609 5.92706791955422e-09 NA NA NA hsa-miR-335-3p SNAI2 2.5197689063267 2.20084506976733e-09 0.8679564879757 0.163674726451342 mirMAP -0.308182854003903 0.00222866592387318 NA NA NA hsa-miR-3614-5p SNAI2 1.10426689932954 0.00706308396674599 0.8679564879757 0.163674726451342 MirTarget -0.422502185264929 9.17833069626897e-05 NA NA NA hsa-miR-375 SNAI2 -2.94506033785642 0.00570147601654791 0.8679564879757 0.163674726451342 miRanda -0.414986060133483 2.04706689528243e-32 NA NA NA hsa-miR-429 SNAI2 1.40182602301928 0.00900426780286475 0.8679564879757 0.163674726451342 PITA;miRanda;miRNATAP -0.392670133124033 1.01237240041389e-06 NA NA NA hsa-miR-532-5p SNAI2 0.313080805824184 0.252248939356301 0.8679564879757 0.163674726451342 PITA -1.32274651095458 1.34874826226459e-18 NA NA NA hsa-miR-10b-3p SNTB1 0.773619331000039 0.0076628900286607 -2.09561808441743 7.02102129073666e-06 miRNATAP -0.368420926432521 0.00162600822219859 NA NA NA hsa-miR-16-2-3p SNTB1 1.8048179609245 2.83095715136409e-09 -2.09561808441743 7.02102129073666e-06 mirMAP -0.432789373120562 4.97660735579764e-05 NA NA NA hsa-miR-21-3p SNTB1 1.75245546017565 2.36505176715025e-10 -2.09561808441743 7.02102129073666e-06 mirMAP -0.351420054415265 0.0028718723728084 NA NA NA hsa-miR-24-3p SNTB1 1.08578167539644 6.18549359075268e-07 -2.09561808441743 7.02102129073666e-06 miRNAWalker2_validate -0.925279231608614 4.35965193314883e-10 NA NA NA hsa-miR-29a-3p SPARC -0.113012156986374 0.615005009685815 1.20490443472811 0.00148081246741369 miRNAWalker2_validate;miRTarBase;miRNATAP -0.554662968055641 5.08205494001294e-06 23023935 microRNA 29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma; Dual-luciferase reporter assays indicated that the SPARC mRNA 3'UTR was directly targeted by miR-29a since the mutated 3'UTR was not affected; Silencing SPARC expression by RNAi knockdown resulted in a similar effect as miR-29a overexpression on hepatocellular carcinoma HCC cell growth regulation liver cancer hsa-miR-29b-3p SPARC -0.230693226193598 0.367461626035234 1.20490443472811 0.00148081246741369 miRNATAP -0.447881300832347 2.60517807346811e-05 NA NA NA hsa-miR-29c-3p SPARC -1.62454036584589 5.38376515586029e-07 1.20490443472811 0.00148081246741369 miRNAWalker2_validate;miRTarBase;miRNATAP -0.387449095162005 1.4415939802126e-06 NA NA NA hsa-miR-3065-5p SPARC -0.241623656423063 0.633116553078159 1.20490443472811 0.00148081246741369 mirMAP -0.163582503741903 0.0030098945184113 NA NA NA hsa-miR-31-5p SPARC 0.666358292391859 0.381800494600846 1.20490443472811 0.00148081246741369 MirTarget -0.103721174159072 0.0058282808348836 NA NA NA hsa-miR-532-3p SPARC 0.552364451472481 0.0975490365586023 1.20490443472811 0.00148081246741369 miRNATAP -0.303624220158161 0.000189534370846794 NA NA NA hsa-miR-625-5p SPARC 0.537211086526376 0.203801009380384 1.20490443472811 0.00148081246741369 MirTarget -0.236615391667481 0.000237015965076824 NA NA NA hsa-miR-7-1-3p SPARC 0.709309110750947 0.0412301737463194 1.20490443472811 0.00148081246741369 mirMAP -0.232205352515136 0.00303935293304106 NA NA NA hsa-miR-126-5p SPOCK1 0.41765430251855 0.0753161203651532 0.273640727970773 0.676321706638478 mirMAP -1.03787983173093 1.17411269871431e-07 NA NA NA hsa-miR-130b-3p SPOCK1 1.32714007211004 4.78676252285191e-05 0.273640727970773 0.676321706638478 MirTarget -0.436090796095676 0.00189129668413017 NA NA NA hsa-miR-139-5p SPOCK1 -1.83374360776637 1.22019901002824e-09 0.273640727970773 0.676321706638478 PITA;miRanda;miRNATAP -0.483044114088133 0.00110424001521043 NA NA NA hsa-miR-140-5p SPOCK1 0.208193069681326 0.303002433893804 0.273640727970773 0.676321706638478 MirTarget;PITA;miRanda -1.01023472111847 1.42307034880782e-05 NA NA NA hsa-miR-148a-5p SPOCK1 -0.69329616490858 0.0793012233740369 0.273640727970773 0.676321706638478 mirMAP -0.667894604042391 4.55557608271709e-09 NA NA NA hsa-miR-16-1-3p SPOCK1 1.43227522002564 3.70920454953168e-08 0.273640727970773 0.676321706638478 MirTarget -0.505890633599574 0.00371300102404422 NA NA NA hsa-miR-19a-3p SPOCK1 1.26669687448473 0.000105972838514412 0.273640727970773 0.676321706638478 MirTarget -0.441587957300259 0.00166487298174927 NA NA NA hsa-miR-19b-3p SPOCK1 0.759818275708988 0.00652779573186786 0.273640727970773 0.676321706638478 MirTarget -0.527688106528592 0.00153212995537869 NA NA NA hsa-miR-2110 SPOCK1 0.759864042760204 0.0723961390557655 0.273640727970773 0.676321706638478 MirTarget -0.36810582391514 0.000914431460291256 NA NA NA hsa-miR-23a-5p SPOCK1 1.31066638832406 0.00315098553367529 0.273640727970773 0.676321706638478 MirTarget -0.365650917974464 0.000433966141746178 NA NA NA hsa-miR-23b-5p SPOCK1 0.608950043767916 0.0486466728330363 0.273640727970773 0.676321706638478 MirTarget -0.434478207000806 0.00537977006674131 NA NA NA hsa-miR-26b-5p SPOCK1 -0.301646326928219 0.160081421968103 0.273640727970773 0.676321706638478 mirMAP -0.799037021092368 0.000275057850485219 NA NA NA hsa-miR-30d-3p SPOCK1 -0.545113326540761 0.0433733076874155 0.273640727970773 0.676321706638478 mirMAP -0.951802822458541 1.64047717514721e-08 NA NA NA hsa-miR-326 SPOCK1 -0.429748586406214 0.2629894124021 0.273640727970773 0.676321706638478 MirTarget;miRanda -0.495696659555557 4.55764315295371e-05 NA NA NA hsa-miR-330-5p SPOCK1 0.488365986827708 0.0512207630808233 0.273640727970773 0.676321706638478 MirTarget;miRanda -0.581973190023129 0.00189821794815708 NA NA NA hsa-miR-33a-3p SPOCK1 0.347011402017138 0.321709379745392 0.273640727970773 0.676321706638478 mirMAP -0.519336546728101 0.000198021314954259 NA NA NA hsa-miR-3662 SPOCK1 1.82780708047676 0.0054036501346178 0.273640727970773 0.676321706638478 MirTarget;mirMAP -0.251963106995646 0.00560249354499433 NA NA NA hsa-miR-375 SPOCK1 -2.94506033785642 0.00570147601654791 0.273640727970773 0.676321706638478 miRNATAP -0.301483092549233 1.25012926470081e-13 NA NA NA hsa-miR-429 SPOCK1 1.40182602301928 0.00900426780286475 0.273640727970773 0.676321706638478 miRNATAP -0.447211244456047 9.46859047900271e-08 NA NA NA hsa-miR-501-3p SPOCK1 0.731876211669996 0.0270421347018303 0.273640727970773 0.676321706638478 PITA;TargetScan;miRNATAP -0.60858999229279 1.15012155802489e-05 NA NA NA hsa-miR-502-3p SPOCK1 -0.16442685491191 0.557471818466728 0.273640727970773 0.676321706638478 PITA;miRNATAP -0.94385235903615 6.30773469491156e-09 NA NA NA hsa-miR-582-5p SPOCK1 -0.448820171762719 0.134615974001015 0.273640727970773 0.676321706638478 PITA;miRNATAP -0.404511516624654 0.00973690547840224 NA NA NA hsa-miR-590-3p SPOCK1 1.11654983899947 0.000160782154924864 0.273640727970773 0.676321706638478 PITA;miRanda;mirMAP -0.455928376856676 0.00345017870069012 NA NA NA hsa-miR-590-5p SPOCK1 1.04171442093217 0.000272475544954865 0.273640727970773 0.676321706638478 MirTarget;miRanda;mirMAP -0.471351668330752 0.00352513223381623 NA NA NA hsa-miR-625-5p SPOCK1 0.537211086526376 0.203801009380384 0.273640727970773 0.676321706638478 MirTarget -0.733648919577504 3.18082063038888e-12 NA NA NA hsa-miR-139-5p SPP1 -1.83374360776637 1.22019901002824e-09 4.08243806089987 4.65153594324165e-07 miRanda -1.0978692410805 1.97313678323349e-09 NA NA NA hsa-miR-146a-5p SPP1 1.82051649415508 2.03651725047679e-05 4.08243806089987 4.65153594324165e-07 miRNAWalker2_validate -0.450709767193883 0.000899249563093426 NA NA NA hsa-miR-362-3p SPP1 -0.0349414695893027 0.913780708043777 4.08243806089987 4.65153594324165e-07 miRanda -0.628354921443493 0.000692475054752355 NA NA NA hsa-miR-577 SPP1 0.911619788986754 0.2256062124148 4.08243806089987 4.65153594324165e-07 miRNATAP -0.275226769397448 0.000608838686580323 NA NA NA hsa-miR-128-3p TAGLN 0.98280381420517 5.77641850797209e-05 -1.99790451985353 3.33065963281513e-05 miRNAWalker2_validate -0.994215958294001 1.19836123512347e-13 NA NA NA hsa-miR-193a-3p TAGLN 0.214911823818578 0.399323056245552 -1.99790451985353 3.33065963281513e-05 miRanda -0.363653207728099 0.00893589795099115 NA NA NA hsa-miR-26b-5p TAGLN -0.301646326928219 0.160081421968103 -1.99790451985353 3.33065963281513e-05 miRNAWalker2_validate -0.600061064341819 0.000271491791833752 NA NA NA hsa-miR-542-3p TAGLN 0.757649022262991 0.00210575463285599 -1.99790451985353 3.33065963281513e-05 PITA;miRanda -0.5006898815574 0.000400477389960445 NA NA NA hsa-miR-625-5p TAGLN 0.537211086526376 0.203801009380384 -1.99790451985353 3.33065963281513e-05 mirMAP -0.498551966054622 4.48089064315703e-10 NA NA NA hsa-miR-7-5p TAGLN 1.63575693499363 0.0124424214624534 -1.99790451985353 3.33065963281513e-05 miRNAWalker2_validate -0.301544030354581 2.16292767201317e-08 NA NA NA hsa-miR-940 TAGLN 1.64406174271686 0.000690854900107004 -1.99790451985353 3.33065963281513e-05 MirTarget;PITA;miRNATAP -0.383722802491944 3.55033515282683e-06 NA NA NA hsa-miR-139-5p TGFB1 -1.83374360776637 1.22019901002824e-09 0.921978024389205 0.015443067273438 miRanda -0.231228229661 0.00779949032347728 NA NA NA hsa-miR-29b-3p TGFB1 -0.230693226193598 0.367461626035234 0.921978024389205 0.015443067273438 miRTarBase -0.456958304413375 1.70622144738106e-05 NA NA NA hsa-miR-30a-5p TGFBI -1.71922855140016 3.20574349285256e-07 1.64753177965957 0.0016234915431889 miRNAWalker2_validate -0.431991847616242 6.00992201694973e-05 NA NA NA hsa-miR-362-3p TGFBI -0.0349414695893027 0.913780708043777 1.64753177965957 0.0016234915431889 miRanda -0.445982131648649 0.000132181951715914 NA NA NA hsa-miR-429 TGFBI 1.40182602301928 0.00900426780286475 1.64753177965957 0.0016234915431889 miRanda -0.275935469236925 5.9403692954823e-05 NA NA NA hsa-miR-15a-5p TGFBR3 1.03783090449383 7.40334108980898e-07 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.717762702969539 2.23693689380416e-05 NA NA NA hsa-miR-15b-5p TGFBR3 1.62046407540723 5.42152621571078e-09 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.558319586365568 7.28016246351776e-06 NA NA NA hsa-miR-16-2-3p TGFBR3 1.8048179609245 2.83095715136409e-09 -2.5453489359487 2.55855407656975e-07 mirMAP -0.483674400691069 2.0877588558894e-05 NA NA NA hsa-miR-16-5p TGFBR3 1.00515772948091 5.33912942007619e-06 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.679314806633212 2.47983231355558e-05 NA NA NA hsa-miR-182-5p TGFBR3 0.887369486030646 0.0310640781418789 -2.5453489359487 2.55855407656975e-07 miRNATAP -0.290896100418916 0.000889552903550763 NA NA NA hsa-miR-185-3p TGFBR3 1.33711019171256 3.45756583967985e-05 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.363968822089794 0.000966212518334601 NA NA NA hsa-miR-18a-3p TGFBR3 2.35188582849667 1.39401350286321e-08 -2.5453489359487 2.55855407656975e-07 MirTarget -0.385102077244319 3.5046360319332e-06 NA NA NA hsa-miR-18a-5p TGFBR3 2.20211504140984 1.78678887916334e-09 -2.5453489359487 2.55855407656975e-07 MirTarget -0.433710499252048 3.48292958396425e-06 NA NA NA hsa-miR-193b-3p TGFBR3 0.281752012268679 0.451258902263119 -2.5453489359487 2.55855407656975e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.498828173102988 1.48286052396892e-07 NA NA NA hsa-miR-21-5p TGFBR3 1.75445050487988 2.41825549682022e-23 -2.5453489359487 2.55855407656975e-07 miRNAWalker2_validate -1.1197191216922 5.22599460161761e-10 NA NA NA hsa-miR-222-5p TGFBR3 1.87968474330782 1.11743009485711e-06 -2.5453489359487 2.55855407656975e-07 MirTarget -0.279904853457402 0.0021888634533865 NA NA NA hsa-miR-23a-3p TGFBR3 1.10685926969665 3.16223452471768e-08 -2.5453489359487 2.55855407656975e-07 MirTarget;mirMAP -0.761242920104668 1.57215702647613e-05 NA NA NA hsa-miR-27a-3p TGFBR3 1.29886998470345 2.68986118553486e-08 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.735484806135868 7.54795324711613e-07 NA NA NA hsa-miR-296-5p TGFBR3 0.932146077883618 0.0602370559607489 -2.5453489359487 2.55855407656975e-07 MirTarget -0.258685442678788 0.00062347209493997 NA NA NA hsa-miR-323b-3p TGFBR3 1.13581624461921 0.0214847831286342 -2.5453489359487 2.55855407656975e-07 miRNATAP -0.242636472096206 0.00326963836690031 NA NA NA hsa-miR-335-3p TGFBR3 2.5197689063267 2.20084506976733e-09 -2.5453489359487 2.55855407656975e-07 mirMAP -0.267681362921701 0.00113634123062514 NA NA NA hsa-miR-424-5p TGFBR3 1.08509868581983 0.000420473853818268 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.592962460480752 2.08106075810596e-07 NA NA NA hsa-miR-455-5p TGFBR3 1.20462751989145 6.74386011867484e-05 -2.5453489359487 2.55855407656975e-07 miRanda -0.828622912452922 1.24229170584621e-13 NA NA NA hsa-miR-484 TGFBR3 0.71327898984355 0.00233605130771196 -2.5453489359487 2.55855407656975e-07 MirTarget;miRNATAP -0.567949380275866 0.00023819450324354 NA NA NA hsa-miR-590-3p TGFBR3 1.11654983899947 0.000160782154924864 -2.5453489359487 2.55855407656975e-07 MirTarget;miRanda;mirMAP -0.327080534392386 0.00716732139849971 NA NA NA hsa-miR-590-5p TGFBR3 1.04171442093217 0.000272475544954865 -2.5453489359487 2.55855407656975e-07 miRanda -0.439937187151358 0.000441953048943132 NA NA NA hsa-miR-944 TGFBR3 3.33123095809751 0.0177835044930391 -2.5453489359487 2.55855407656975e-07 mirMAP -0.121565213683814 5.40521086016591e-05 NA NA NA hsa-miR-106a-5p TGM2 -0.173255688252641 0.642872703263671 -0.149978154409172 0.76848261390556 MirTarget -0.263253971730455 0.00682875598784908 NA NA NA hsa-miR-106b-5p TGM2 1.70863907461894 2.04074794107142e-08 -0.149978154409172 0.76848261390556 MirTarget -0.342868588833078 0.00285451650873961 NA NA NA hsa-miR-17-5p TGM2 1.65862087862483 8.45603406215941e-08 -0.149978154409172 0.76848261390556 MirTarget -0.337289391772645 0.00295143654607425 NA NA NA hsa-miR-20a-5p TGM2 1.4503375861709 5.7813456424762e-07 -0.149978154409172 0.76848261390556 MirTarget -0.321735026418845 0.00843153191422223 NA NA NA hsa-miR-320c TGM2 0.455072851945474 0.240613785444485 -0.149978154409172 0.76848261390556 miRanda -0.292887075046475 0.00692536767854486 NA NA NA hsa-miR-324-3p TGM2 1.04940352369965 0.000387716796520961 -0.149978154409172 0.76848261390556 MirTarget -0.635932717820297 7.6540043132277e-08 NA NA NA hsa-miR-93-5p TGM2 1.7515174434778 1.59386482413883e-08 -0.149978154409172 0.76848261390556 MirTarget -0.359791812588266 0.00140745288647612 NA NA NA hsa-let-7a-3p THBS1 0.503048155002889 0.0411145454335299 -1.24863771457813 0.00265778570679874 mirMAP -0.370316910362625 0.00243643875584214 NA NA NA hsa-let-7d-5p THBS1 0.981733854788227 7.26366577706469e-07 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.546987837424227 0.000232224726694981 NA NA NA hsa-miR-151a-3p THBS1 1.00322719901751 7.20903658270795e-06 -1.24863771457813 0.00265778570679874 MirTarget -0.73761432994829 9.23927372162971e-09 NA NA NA hsa-miR-16-1-3p THBS1 1.43227522002564 3.70920454953168e-08 -1.24863771457813 0.00265778570679874 MirTarget -0.475768138699209 1.58834110541284e-05 NA NA NA hsa-miR-17-5p THBS1 1.65862087862483 8.45603406215941e-08 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.477234270724459 1.76065486884735e-07 NA NA NA hsa-miR-182-5p THBS1 0.887369486030646 0.0310640781418789 -1.24863771457813 0.00265778570679874 MirTarget -0.309551358917175 1.40311941430649e-05 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.149964130725901 0.434709542998771 -1.24863771457813 0.00265778570679874 mirMAP -0.520998790228557 0.00106972433199894 NA NA NA hsa-miR-18a-5p THBS1 2.20211504140984 1.78678887916334e-09 -1.24863771457813 0.00265778570679874 MirTarget -0.397796098250484 1.86835263945503e-07 NA NA NA hsa-miR-19a-3p THBS1 1.26669687448473 0.000105972838514412 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.373099495159569 2.8124340301922e-05 NA NA NA hsa-miR-19b-3p THBS1 0.759818275708988 0.00652779573186786 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.475934731509183 6.15248588571142e-06 NA NA NA hsa-miR-200a-5p THBS1 1.50371809098978 0.00263602434344863 -1.24863771457813 0.00265778570679874 MirTarget -0.391138424820444 2.988456435559e-12 NA NA NA hsa-miR-200b-5p THBS1 0.969871521250413 0.0530500454130183 -1.24863771457813 0.00265778570679874 MirTarget -0.428970652872064 2.73273845947343e-13 NA NA NA hsa-miR-20a-5p THBS1 1.4503375861709 5.7813456424762e-07 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.49794382461585 4.0938227581297e-07 NA NA NA hsa-miR-3065-5p THBS1 -0.241623656423063 0.633116553078159 -1.24863771457813 0.00265778570679874 MirTarget -0.249036989118658 3.04281341597343e-05 NA NA NA hsa-miR-32-5p THBS1 0.415247682945382 0.106458022460373 -1.24863771457813 0.00265778570679874 mirMAP -0.5555340737988 1.3387339745154e-06 NA NA NA hsa-miR-335-3p THBS1 2.5197689063267 2.20084506976733e-09 -1.24863771457813 0.00265778570679874 mirMAP -0.401833811450832 7.76964738276262e-10 NA NA NA hsa-miR-33a-3p THBS1 0.347011402017138 0.321709379745392 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.531341072213548 9.05114561069452e-10 NA NA NA hsa-miR-375 THBS1 -2.94506033785642 0.00570147601654791 -1.24863771457813 0.00265778570679874 miRanda -0.121276767953717 8.45936054053377e-06 NA NA NA hsa-miR-576-5p THBS1 0.625714137488957 0.0417100301848969 -1.24863771457813 0.00265778570679874 mirMAP -0.41902887625134 1.27872122980434e-05 NA NA NA hsa-miR-577 THBS1 0.911619788986754 0.2256062124148 -1.24863771457813 0.00265778570679874 mirMAP -0.235350281618529 1.68539263735026e-09 NA NA NA hsa-miR-590-3p THBS1 1.11654983899947 0.000160782154924864 -1.24863771457813 0.00265778570679874 miRanda -0.453209723492059 3.97290709629156e-06 NA NA NA hsa-miR-590-5p THBS1 1.04171442093217 0.000272475544954865 -1.24863771457813 0.00265778570679874 miRanda;mirMAP -0.477091842103574 2.72141337877697e-06 NA NA NA hsa-miR-616-5p THBS1 0.834052908652744 0.0347835664029363 -1.24863771457813 0.00265778570679874 mirMAP -0.231533516554552 0.00253501598736982 NA NA NA hsa-miR-629-3p THBS1 1.40326397107309 9.7803063526732e-05 -1.24863771457813 0.00265778570679874 MirTarget -0.437479666325319 3.50844628225438e-08 NA NA NA hsa-miR-7-1-3p THBS1 0.709309110750947 0.0412301737463194 -1.24863771457813 0.00265778570679874 MirTarget;mirMAP -0.367898102747668 1.39963947465173e-05 NA NA NA hsa-miR-92a-3p THBS1 1.2209325870225 6.8757197708107e-06 -1.24863771457813 0.00265778570679874 miRNAWalker2_validate -0.651028463510854 4.08823366684469e-10 NA NA NA hsa-miR-940 THBS1 1.64406174271686 0.000690854900107004 -1.24863771457813 0.00265778570679874 MirTarget -0.24008111432213 0.000798882289984547 NA NA NA hsa-miR-106b-5p THBS2 1.70863907461894 2.04074794107142e-08 1.37350866437698 0.0129752854334954 MirTarget -0.440457832160164 0.000432717084292189 NA NA NA hsa-miR-139-5p THBS2 -1.83374360776637 1.22019901002824e-09 1.37350866437698 0.0129752854334954 miRanda -0.688708303020105 1.88206306869675e-08 NA NA NA hsa-miR-142-5p THBS2 1.55592486377018 6.69269968016779e-06 1.37350866437698 0.0129752854334954 mirMAP -0.308007373998275 0.00610533418094202 NA NA NA hsa-miR-16-2-3p THBS2 1.8048179609245 2.83095715136409e-09 1.37350866437698 0.0129752854334954 mirMAP -0.338689543432002 0.00707068722064666 NA NA NA hsa-miR-29a-3p THBS2 -0.113012156986374 0.615005009685815 1.37350866437698 0.0129752854334954 MirTarget -0.729305331657521 3.98799108454678e-05 NA NA NA hsa-miR-29b-3p THBS2 -0.230693226193598 0.367461626035234 1.37350866437698 0.0129752854334954 MirTarget -0.625558466486523 5.42630924237139e-05 NA NA NA hsa-miR-29c-3p THBS2 -1.62454036584589 5.38376515586029e-07 1.37350866437698 0.0129752854334954 MirTarget -0.507936113984382 1.53033375740441e-05 NA NA NA hsa-miR-32-3p THBS2 0.583525764322974 0.11837203008551 1.37350866437698 0.0129752854334954 miRNATAP -0.474999749946423 5.82517221808817e-05 NA NA NA hsa-miR-320a THBS2 0.593888711838028 0.011897419390526 1.37350866437698 0.0129752854334954 mirMAP -0.471079112967222 0.00536169354189666 NA NA NA hsa-miR-320b THBS2 1.11183660885284 0.000497971211648503 1.37350866437698 0.0129752854334954 mirMAP -0.365660979087471 0.00290369121195031 NA NA NA hsa-miR-3614-5p THBS2 1.10426689932954 0.00706308396674599 1.37350866437698 0.0129752854334954 miRNATAP -0.274609136175736 0.00474383470091683 NA NA NA hsa-miR-590-3p THBS2 1.11654983899947 0.000160782154924864 1.37350866437698 0.0129752854334954 miRanda;mirMAP -0.546312745533517 3.0323695758298e-05 NA NA NA hsa-miR-590-5p THBS2 1.04171442093217 0.000272475544954865 1.37350866437698 0.0129752854334954 miRanda -0.469376124829186 0.0005951523629776 NA NA NA hsa-miR-598-3p THBS2 -0.386724439940895 0.290183721937095 1.37350866437698 0.0129752854334954 MirTarget -0.35042284264785 0.00120759407098702 NA NA NA hsa-miR-7-1-3p THBS2 0.709309110750947 0.0412301737463194 1.37350866437698 0.0129752854334954 MirTarget;mirMAP -0.57975425143221 1.83341309606968e-07 NA NA NA hsa-miR-338-3p THY1 -0.959276231066179 0.0191473351014091 1.49352668907097 7.59448927471933e-05 mirMAP -0.241741345795042 0.000248545828068941 NA NA NA hsa-let-7f-1-3p TIMP3 1.28704406797397 1.17954701106157e-06 -1.70644787580037 0.000213669228366525 mirMAP -0.522178429873345 1.83312604585307e-05 NA NA NA hsa-miR-103a-3p TIMP3 0.840525139266028 5.83536475789158e-07 -1.70644787580037 0.000213669228366525 miRNAWalker2_validate;miRTarBase -1.13863673704363 3.14961172115359e-09 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106a-5p TIMP3 -0.173255688252641 0.642872703263671 -1.70644787580037 0.000213669228366525 miRNATAP -0.338219766262043 0.000138147028890421 NA NA NA hsa-miR-106b-5p TIMP3 1.70863907461894 2.04074794107142e-08 -1.70644787580037 0.000213669228366525 miRNATAP -0.725505175034599 4.24814892976205e-13 NA NA NA hsa-miR-144-3p TIMP3 -0.13309578176575 0.798245647923351 -1.70644787580037 0.000213669228366525 miRNATAP -0.308974826142237 1.08615821132145e-06 NA NA NA hsa-miR-148a-5p TIMP3 -0.69329616490858 0.0793012233740369 -1.70644787580037 0.000213669228366525 mirMAP -0.376955546922131 5.41289425017561e-06 NA NA NA hsa-miR-16-1-3p TIMP3 1.43227522002564 3.70920454953168e-08 -1.70644787580037 0.000213669228366525 mirMAP -0.721164936536576 2.08383588505511e-09 NA NA NA hsa-miR-16-5p TIMP3 1.00515772948091 5.33912942007619e-06 -1.70644787580037 0.000213669228366525 miRNAWalker2_validate -1.1510655460693 1.07217508272373e-16 NA NA NA hsa-miR-181a-5p TIMP3 1.39227281909646 1.91689469974826e-09 -1.70644787580037 0.000213669228366525 MirTarget;miRNATAP -0.395524775697402 0.00459171037477296 NA NA NA hsa-miR-181b-5p TIMP3 1.64216500592669 1.89228845300725e-08 -1.70644787580037 0.000213669228366525 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.407101107264225 0.000207192756595578 27383203 Moreover miR-181b was found to directly target the 3' untranslated region 3'UTR of Timp3 mRNA affecting TGF-β-induced EMT gastric cancer hsa-miR-188-5p TIMP3 1.35426907033843 0.00038346077691455 -1.70644787580037 0.000213669228366525 mirMAP -0.536104430371826 8.59650757745938e-11 NA NA NA hsa-miR-20a-5p TIMP3 1.4503375861709 5.7813456424762e-07 -1.70644787580037 0.000213669228366525 miRNATAP -0.667853426690571 6.28108993601366e-10 NA NA NA hsa-miR-221-3p TIMP3 1.33496247538338 3.82022531235275e-07 -1.70644787580037 0.000213669228366525 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.700908095823165 5.28698888852969e-09 27077469 MiR 221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma; The results indicated that miR-221 exacerbated PTC by downregulating the expression of TIMP3; The effects of miR-221 and TIMP3 in vivo were also confirmed by human PTC-bearing mice models which suggest consistent results with those in vitro studies thyroid cancer hsa-miR-222-3p TIMP3 1.39382731585819 9.98182478024671e-07 -1.70644787580037 0.000213669228366525 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.695748920443262 2.48610668919191e-10 NA NA NA hsa-miR-30d-5p TIMP3 -0.5492586056147 0.0140125082460125 -1.70644787580037 0.000213669228366525 miRNATAP -0.509651871261568 0.000682972571449174 NA NA NA hsa-miR-32-3p TIMP3 0.583525764322974 0.11837203008551 -1.70644787580037 0.000213669228366525 mirMAP;miRNATAP -0.578630862990153 2.44754743353702e-09 NA NA NA hsa-miR-3200-3p TIMP3 0.93510295722357 0.0984236007399256 -1.70644787580037 0.000213669228366525 mirMAP -0.18897879944817 0.00383110663430012 NA NA NA hsa-miR-330-3p TIMP3 0.798460296022179 0.00746538156533435 -1.70644787580037 0.000213669228366525 mirMAP -0.427535520820206 0.000110463997464408 NA NA NA hsa-miR-335-5p TIMP3 1.59953351087307 5.56170899867314e-05 -1.70644787580037 0.000213669228366525 miRNAWalker2_validate -0.476414860267456 2.15936578835782e-09 NA NA NA hsa-miR-338-5p TIMP3 -1.19659203838734 0.0100316010080496 -1.70644787580037 0.000213669228366525 PITA;miRNATAP -0.250077239076849 0.000407037925387423 NA NA NA hsa-miR-3607-3p TIMP3 0.522750552658156 0.0842510989344654 -1.70644787580037 0.000213669228366525 MirTarget;miRNATAP -0.351033464607969 0.00144937815279957 NA NA NA hsa-miR-362-3p TIMP3 -0.0349414695893027 0.913780708043777 -1.70644787580037 0.000213669228366525 miRanda -0.357276142263203 0.000570836322351806 NA NA NA hsa-miR-3662 TIMP3 1.82780708047676 0.0054036501346178 -1.70644787580037 0.000213669228366525 MirTarget;mirMAP;miRNATAP -0.334951697830204 1.25203682901906e-07 NA NA NA hsa-miR-423-5p TIMP3 0.832613878736338 0.000791321227103338 -1.70644787580037 0.000213669228366525 miRNAWalker2_validate -0.536007217465093 5.48144709312119e-05 NA NA NA hsa-miR-505-3p TIMP3 0.82660100642669 0.00111666333288398 -1.70644787580037 0.000213669228366525 mirMAP -0.563264716675393 1.37543690393143e-05 NA NA NA hsa-miR-577 TIMP3 0.911619788986754 0.2256062124148 -1.70644787580037 0.000213669228366525 mirMAP -0.292694733581597 1.06411221300706e-11 NA NA NA hsa-miR-589-3p TIMP3 1.01962606923682 0.00577853347252709 -1.70644787580037 0.000213669228366525 mirMAP -0.365642585923829 3.70627737003655e-05 NA NA NA hsa-miR-590-3p TIMP3 1.11654983899947 0.000160782154924864 -1.70644787580037 0.000213669228366525 PITA;miRanda;miRNATAP -0.532679156468469 1.10118620534107e-06 NA NA NA hsa-miR-590-5p TIMP3 1.04171442093217 0.000272475544954865 -1.70644787580037 0.000213669228366525 MirTarget;PITA;miRanda;miRNATAP -0.637379171737504 1.27944929788738e-08 NA NA NA hsa-miR-616-5p TIMP3 0.834052908652744 0.0347835664029363 -1.70644787580037 0.000213669228366525 mirMAP -0.363281440908019 1.7452580232789e-05 NA NA NA hsa-miR-660-5p TIMP3 -0.0206552819434673 0.938868734063643 -1.70644787580037 0.000213669228366525 miRNATAP -0.469783011490907 0.00015451701134465 NA NA NA hsa-miR-7-1-3p TIMP3 0.709309110750947 0.0412301737463194 -1.70644787580037 0.000213669228366525 mirMAP -0.6359852092124 2.81447257914457e-12 NA NA NA hsa-miR-126-5p TNC 0.41765430251855 0.0753161203651532 0.961893359853532 0.177941026307477 miRNATAP -0.983390994749709 5.2459973603903e-06 NA NA NA hsa-miR-326 TNC -0.429748586406214 0.2629894124021 0.961893359853532 0.177941026307477 MirTarget;miRanda;miRNATAP -0.695390877950542 1.05430372708077e-07 NA NA NA hsa-miR-330-3p TNC 0.798460296022179 0.00746538156533435 0.961893359853532 0.177941026307477 MirTarget -0.442492776074701 0.00951460349625162 NA NA NA hsa-miR-330-5p TNC 0.488365986827708 0.0512207630808233 0.961893359853532 0.177941026307477 MirTarget;miRanda;miRNATAP -0.557515682229666 0.0065862461944099 NA NA NA hsa-miR-335-5p TNC 1.59953351087307 5.56170899867314e-05 0.961893359853532 0.177941026307477 miRNAWalker2_validate;miRTarBase -0.77847754082114 1.10622361056312e-10 NA NA NA hsa-miR-425-5p TNC 1.13924952403101 0.000255357546232931 0.961893359853532 0.177941026307477 MirTarget -0.773139534334497 1.07174674118418e-06 NA NA NA hsa-miR-501-5p TNC 0.266919328110625 0.454779001968586 0.961893359853532 0.177941026307477 miRNATAP -0.919424595130222 1.57363704377471e-11 NA NA NA hsa-miR-429 TNFAIP3 1.40182602301928 0.00900426780286475 1.18002506926414 0.00155875155721508 miRanda -0.129627113428861 0.00893626228492971 NA NA NA hsa-miR-145-5p TNFRSF11B -1.75133578902314 1.54965572197748e-05 1.69396269527235 0.0169608144769363 miRNATAP -0.400680537832621 0.00105185248513234 NA NA NA hsa-miR-34c-5p TNFRSF11B 2.20632574870337 0.000379662996168678 1.69396269527235 0.0169608144769363 miRanda -0.436012825295469 3.06219169989682e-08 NA NA NA hsa-let-7a-3p TPM1 0.503048155002889 0.0411145454335299 -1.20159913203862 0.000170371056171373 miRNATAP -0.488011436913186 1.21544190571399e-07 NA NA NA hsa-let-7b-3p TPM1 0.21838629112113 0.296038413622566 -1.20159913203862 0.000170371056171373 miRNATAP -0.371779402021126 0.000943387660494616 NA NA NA hsa-miR-125a-3p TPM1 1.19506542853853 0.00164364545717311 -1.20159913203862 0.000170371056171373 miRanda -0.162023393129123 0.00788346370797216 NA NA NA hsa-miR-1271-5p TPM1 1.15538250415776 0.00207865862606828 -1.20159913203862 0.000170371056171373 MirTarget -0.280466936259031 3.9420604905239e-06 NA NA NA hsa-miR-142-3p TPM1 1.32364054836498 0.0001537753622128 -1.20159913203862 0.000170371056171373 miRanda -0.29718293356046 3.43604472158435e-06 NA NA NA hsa-miR-146b-5p TPM1 1.547491371264 6.06614361290688e-08 -1.20159913203862 0.000170371056171373 miRanda -0.289112752652037 0.00021036702248642 NA NA NA hsa-miR-183-5p TPM1 1.65900927871187 0.000522025364980187 -1.20159913203862 0.000170371056171373 MirTarget;miRNATAP -0.292971310538138 1.3069347128263e-10 NA NA NA hsa-miR-21-5p TPM1 1.75445050487988 2.41825549682022e-23 -1.20159913203862 0.000170371056171373 miRNAWalker2_validate;miRTarBase -0.385977565860776 0.00115754022785403 20952761;23558936 These two miRNAs have previously been identified as being overexpressed in MCF-7 breast cancer cells with miR-21 specifically implicated in down-regulating the tumor suppressor gene tropomyosin-1;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1 ;progression breast cancer;kidney renal cell cancer hsa-miR-320b TPM1 1.11183660885284 0.000497971211648503 -1.20159913203862 0.000170371056171373 miRanda -0.204689035874239 0.00428033971582949 NA NA NA hsa-miR-320c TPM1 0.455072851945474 0.240613785444485 -1.20159913203862 0.000170371056171373 miRanda -0.186250400918203 0.00708062339154888 NA NA NA hsa-miR-33a-3p TPM1 0.347011402017138 0.321709379745392 -1.20159913203862 0.000170371056171373 miRNATAP -0.358022208561812 1.3489677709705e-07 NA NA NA hsa-miR-429 TPM1 1.40182602301928 0.00900426780286475 -1.20159913203862 0.000170371056171373 miRNATAP -0.184709282375328 1.09190413096182e-05 NA NA NA hsa-miR-455-5p TPM1 1.20462751989145 6.74386011867484e-05 -1.20159913203862 0.000170371056171373 miRanda -0.373726879930167 4.03855784202434e-07 NA NA NA hsa-miR-542-3p TPM1 0.757649022262991 0.00210575463285599 -1.20159913203862 0.000170371056171373 PITA;miRanda;miRNATAP -0.365901211776149 8.3901513541628e-05 NA NA NA hsa-miR-590-3p TPM1 1.11654983899947 0.000160782154924864 -1.20159913203862 0.000170371056171373 miRanda -0.394556744391162 1.66254636352775e-07 NA NA NA hsa-miR-944 TPM1 3.33123095809751 0.0177835044930391 -1.20159913203862 0.000170371056171373 mirMAP -0.105577370579823 1.89043485180506e-08 NA NA NA hsa-miR-96-5p TPM1 1.14243043653372 0.00942969392739105 -1.20159913203862 0.000170371056171373 MirTarget;TargetScan;miRNATAP -0.300833422358586 1.3659486252095e-08 NA NA NA hsa-miR-15a-5p TPM2 1.03783090449383 7.40334108980898e-07 -1.58482368387581 4.52363336754253e-05 MirTarget -0.82523857196874 9.63056610107711e-11 NA NA NA hsa-miR-15b-5p TPM2 1.62046407540723 5.42152621571078e-09 -1.58482368387581 4.52363336754253e-05 MirTarget -0.601714842119453 1.62904774500654e-10 NA NA NA hsa-miR-16-5p TPM2 1.00515772948091 5.33912942007619e-06 -1.58482368387581 4.52363336754253e-05 MirTarget -0.919923850660823 8.62115807642203e-15 NA NA NA hsa-miR-185-5p TPM2 1.14351510556643 1.07346945085714e-08 -1.58482368387581 4.52363336754253e-05 MirTarget -0.90507406276296 6.3544931825523e-12 NA NA NA hsa-miR-320b TPM2 1.11183660885284 0.000497971211648503 -1.58482368387581 4.52363336754253e-05 miRanda -0.286216788111708 0.00102432663458634 NA NA NA hsa-miR-339-5p TPM2 0.770566566962108 0.00816529093411862 -1.58482368387581 4.52363336754253e-05 miRanda -0.608246907178556 4.86933358681072e-11 NA NA NA hsa-miR-423-5p TPM2 0.832613878736338 0.000791321227103338 -1.58482368387581 4.52363336754253e-05 miRNATAP -0.346890507564845 0.00221319624866911 NA NA NA hsa-miR-424-5p TPM2 1.08509868581983 0.000420473853818268 -1.58482368387581 4.52363336754253e-05 MirTarget -0.459765641655538 2.15425602343633e-07 NA NA NA hsa-miR-96-5p TPM2 1.14243043653372 0.00942969392739105 -1.58482368387581 4.52363336754253e-05 TargetScan -0.33566001266893 2.56548749169192e-07 NA NA NA hsa-miR-125a-5p TPM4 -0.878090699011564 0.000213630844319685 0.60851479931965 0.00131348249482819 miRNAWalker2_validate -0.196566195413311 0.000528271283536125 NA NA NA hsa-miR-2110 TPM4 0.759864042760204 0.0723961390557655 0.60851479931965 0.00131348249482819 miRNATAP -0.11624514545124 0.000302225813333063 NA NA NA hsa-miR-30a-5p TPM4 -1.71922855140016 3.20574349285256e-07 0.60851479931965 0.00131348249482819 miRNATAP -0.127566036537592 0.00107783175865299 NA NA NA hsa-miR-30c-5p TPM4 -0.983130268805942 4.60419218706127e-05 0.60851479931965 0.00131348249482819 miRNATAP -0.278946564212459 3.09092628451749e-07 NA NA NA hsa-miR-30d-5p TPM4 -0.5492586056147 0.0140125082460125 0.60851479931965 0.00131348249482819 miRNATAP -0.293091274042041 1.04524498201683e-06 NA NA NA hsa-miR-101-3p VCAN -0.451263906815861 0.0283387250173031 0.916840245612434 0.0656003592600719 miRNATAP -0.502929345622264 0.004187467998671 NA NA NA hsa-miR-107 VCAN 0.904627575346218 4.67936495073904e-05 0.916840245612434 0.0656003592600719 MirTarget;miRanda;miRNATAP -0.507289961941025 0.00143124817509176 NA NA NA hsa-miR-126-5p VCAN 0.41765430251855 0.0753161203651532 0.916840245612434 0.0656003592600719 mirMAP -0.652464130327704 1.593475406606e-05 NA NA NA hsa-miR-128-3p VCAN 0.98280381420517 5.77641850797209e-05 0.916840245612434 0.0656003592600719 MirTarget -0.490357341708742 0.000654865218686279 NA NA NA hsa-miR-141-3p VCAN 1.45548825076434 0.00115958850961764 0.916840245612434 0.0656003592600719 MirTarget;TargetScan;miRNATAP -0.24786853703214 0.00151210855416606 NA NA NA hsa-miR-144-3p VCAN -0.13309578176575 0.798245647923351 0.916840245612434 0.0656003592600719 miRNATAP -0.209932767425751 0.00229496173507422 NA NA NA hsa-miR-200a-3p VCAN 0.717826667295984 0.193912116506827 0.916840245612434 0.0656003592600719 MirTarget;miRNATAP -0.17265387009369 0.00713986954733391 NA NA NA hsa-miR-203a-3p VCAN 1.44736908507496 0.0394116388736904 0.916840245612434 0.0656003592600719 MirTarget -0.170332448973931 0.000649167223752805 NA NA NA hsa-miR-33a-3p VCAN 0.347011402017138 0.321709379745392 0.916840245612434 0.0656003592600719 mirMAP -0.363904130944463 0.00064920497121657 NA NA NA hsa-miR-33a-5p VCAN 0.407757858040717 0.321429014317207 0.916840245612434 0.0656003592600719 MirTarget -0.286039114339045 0.000900256798129307 NA NA NA hsa-miR-429 VCAN 1.40182602301928 0.00900426780286475 0.916840245612434 0.0656003592600719 miRanda -0.228747560506953 0.000453702501579026 NA NA NA hsa-miR-1-3p VEGFA -2.66410453456934 1.50620580537836e-05 0.409900110754973 0.180026099055787 MirTarget -0.176948917904965 1.45151759893735e-07 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA -0.451263906815861 0.0283387250173031 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.335417986089274 0.00174980396829274 NA NA NA hsa-miR-129-5p VEGFA -2.56914016541176 2.36237896095709e-06 0.409900110754973 0.180026099055787 miRanda -0.105947559794297 0.00736909643879352 NA NA NA hsa-miR-133a-3p VEGFA -3.07408796787523 8.17423849601445e-07 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.162820736618245 8.37210469369392e-07 NA NA NA hsa-miR-145-5p VEGFA -1.75133578902314 1.54965572197748e-05 0.409900110754973 0.180026099055787 miRNAWalker2_validate;miRTarBase -0.220438811665314 2.09241456816908e-05 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-199a-5p VEGFA 0.371973504507027 0.232661597228763 0.409900110754973 0.180026099055787 miRanda;miRNATAP -0.211547585175076 0.00251514147236996 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-128-3p VEGFC 0.98280381420517 5.77641850797209e-05 0.195788328347819 0.656066637612163 miRNAWalker2_validate;MirTarget -0.546088637678822 1.30628253642657e-05 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 1.8048179609245 2.83095715136409e-09 0.195788328347819 0.656066637612163 MirTarget -0.260465880829614 0.00866041293845893 NA NA NA hsa-miR-3662 VEGFC 1.82780708047676 0.0054036501346178 0.195788328347819 0.656066637612163 MirTarget -0.187356869827338 0.00206421517630613 NA NA NA hsa-miR-16-5p VIM 1.00515772948091 5.33912942007619e-06 -0.439360643666186 0.170530094116735 miRNAWalker2_validate -0.502598571236578 5.29879134037281e-07 NA NA NA hsa-miR-17-3p VIM 1.31126744284937 3.24768335024185e-07 -0.439360643666186 0.170530094116735 miRNAWalker2_validate;miRNATAP -0.461249515960649 5.01178296842559e-08 19771525;23418359 The lack of miR-17-3p expression correlated with an increase in vimentin synthesis and tumorigenicity; Stable expression of miR-17-3p in the M12 subline reduced vimentin levels 85% and reverted growth to organized polarized acini in lrECM gels;In contrast the passenger strand miR-17-3p repressed expression of vimentin an intermediate filament with the ability to modulate metabolism and GalNT7 an enzyme that regulates metabolism of liver toxin galactosamine ; prostate cancer;liver cancer hsa-miR-30d-5p VIM -0.5492586056147 0.0140125082460125 -0.439360643666186 0.170530094116735 miRNATAP -0.368038072115724 0.000328498762475849 NA NA NA hsa-miR-320a VIM 0.593888711838028 0.011897419390526 -0.439360643666186 0.170530094116735 PITA;miRanda;miRNATAP -0.265739107019836 0.00637483831239571 27448976 miR-320a was found to bind to the 3'UTR of both vimentin and USP14 transcripts and downregulate the expression of both proteins gastric cancer hsa-miR-320b VIM 1.11183660885284 0.000497971211648503 -0.439360643666186 0.170530094116735 PITA;miRanda;miRNATAP -0.218006352171866 0.00202155268849666 NA NA NA hsa-miR-320c VIM 0.455072851945474 0.240613785444485 -0.439360643666186 0.170530094116735 PITA;miRanda;miRNATAP -0.217203401301307 0.00140829143162105 NA NA NA hsa-miR-590-5p VIM 1.04171442093217 0.000272475544954865 -0.439360643666186 0.170530094116735 PITA;miRanda;miRNATAP -0.267364406020468 0.000680962087304792 NA NA NA hsa-miR-615-3p VIM 2.82967143704683 3.05118423223543e-05 -0.439360643666186 0.170530094116735 miRNAWalker2_validate -0.170656486024293 0.000164223710873661 NA NA NA hsa-miR-1266-5p WIPF1 0.214881660714884 0.741561405223711 0.0116573235233819 0.97318872431618 MirTarget -0.188051279742209 4.8622918790223e-07 NA NA NA hsa-miR-141-3p WIPF1 1.45548825076434 0.00115958850961764 0.0116573235233819 0.97318872431618 MirTarget;TargetScan;miRNATAP -0.307708069417876 4.48537777526652e-09 NA NA NA hsa-miR-16-5p WIPF1 1.00515772948091 5.33912942007619e-06 0.0116573235233819 0.97318872431618 miRNAWalker2_validate -0.365920722773009 0.000896762918443146 NA NA NA hsa-miR-182-5p WIPF1 0.887369486030646 0.0310640781418789 0.0116573235233819 0.97318872431618 MirTarget;miRNATAP -0.208662798767303 0.000428228878719727 NA NA NA hsa-miR-200a-3p WIPF1 0.717826667295984 0.193912116506827 0.0116573235233819 0.97318872431618 MirTarget;miRNATAP -0.223742666968903 2.46735575746641e-07 NA NA NA hsa-miR-200b-3p WIPF1 0.974577911407732 0.0595020056914543 0.0116573235233819 0.97318872431618 MirTarget;TargetScan -0.280539851726795 7.58347780205174e-10 NA NA NA hsa-miR-200c-3p WIPF1 1.28185685499076 0.00369777635539177 0.0116573235233819 0.97318872431618 MirTarget;miRNATAP -0.354683154618367 1.62402789283194e-11 NA NA NA hsa-miR-30b-5p WIPF1 -0.430720743745757 0.0593564057320791 0.0116573235233819 0.97318872431618 MirTarget -0.286946029603899 0.00869816976072651 NA NA NA hsa-miR-30d-5p WIPF1 -0.5492586056147 0.0140125082460125 0.0116573235233819 0.97318872431618 MirTarget;miRNATAP -0.402006494151947 0.000278142973223495 NA NA NA hsa-miR-33a-3p WIPF1 0.347011402017138 0.321709379745392 0.0116573235233819 0.97318872431618 MirTarget -0.398000102712131 3.47343391489623e-08 NA NA NA hsa-miR-378a-5p WIPF1 -0.557166502179376 0.0344581590006454 0.0116573235233819 0.97318872431618 MirTarget -0.454234587443189 8.09852436451116e-07 NA NA NA hsa-miR-429 WIPF1 1.40182602301928 0.00900426780286475 0.0116573235233819 0.97318872431618 MirTarget;PITA;miRanda;miRNATAP -0.285578369360156 4.90760597784254e-11 NA NA NA hsa-miR-486-5p WIPF1 -0.627607241830911 0.155274583521138 0.0116573235233819 0.97318872431618 miRanda -0.157544890204139 0.0046460333889374 NA NA NA hsa-miR-577 WIPF1 0.911619788986754 0.2256062124148 0.0116573235233819 0.97318872431618 mirMAP -0.14817371584972 6.50305231899586e-06 NA NA NA hsa-miR-582-3p WIPF1 -0.412897415951272 0.202939245403793 0.0116573235233819 0.97318872431618 PITA -0.209288507366966 0.00607295317954767 NA NA NA hsa-miR-624-5p WIPF1 1.03467956701702 0.0010908013402586 0.0116573235233819 0.97318872431618 MirTarget -0.312478217797699 0.000113556430834048 NA NA NA hsa-miR-7-1-3p WIPF1 0.709309110750947 0.0412301737463194 0.0116573235233819 0.97318872431618 MirTarget;mirMAP -0.201631390478934 0.00439726390104324 NA NA NA hsa-miR-96-5p WIPF1 1.14243043653372 0.00942969392739105 0.0116573235233819 0.97318872431618 miRNATAP -0.24411119228641 2.19538006471473e-05 NA NA NA hsa-miR-140-3p WNT5A -0.296251775392129 0.127539826012144 1.41889465887496 0.00302272108132253 MirTarget;miRNATAP -0.654997547844657 0.000272516279902339 NA NA NA hsa-miR-148a-5p WNT5A -0.69329616490858 0.0793012233740369 1.41889465887496 0.00302272108132253 mirMAP -0.266432697712533 0.00213233612269223 NA NA NA hsa-miR-186-5p WNT5A 0.149964130725901 0.434709542998771 1.41889465887496 0.00302272108132253 miRNAWalker2_validate;mirMAP;miRNATAP -0.596923529656949 0.00113609892095247 NA NA NA hsa-miR-2110 WNT5A 0.759864042760204 0.0723961390557655 1.41889465887496 0.00302272108132253 MirTarget -0.233877228710552 0.00444047447373778 NA NA NA hsa-miR-29a-5p WNT5A 0.585084040404152 0.023014129158495 1.41889465887496 0.00302272108132253 mirMAP -0.458967614840154 0.000602375776214386 NA NA NA hsa-miR-30a-3p WNT5A -1.73205137750899 3.2425754511091e-07 1.41889465887496 0.00302272108132253 mirMAP -0.280674702827158 0.00442239689083578 NA NA NA hsa-miR-30a-5p WNT5A -1.71922855140016 3.20574349285256e-07 1.41889465887496 0.00302272108132253 miRNAWalker2_validate;mirMAP -0.30560196566196 0.00207001162461839 NA NA NA hsa-miR-30b-5p WNT5A -0.430720743745757 0.0593564057320791 1.41889465887496 0.00302272108132253 mirMAP -0.425807828312639 0.00526169426726682 NA NA NA hsa-miR-30c-5p WNT5A -0.983130268805942 4.60419218706127e-05 1.41889465887496 0.00302272108132253 mirMAP -0.441333932103179 0.0017917746829392 NA NA NA hsa-miR-30d-3p WNT5A -0.545113326540761 0.0433733076874155 1.41889465887496 0.00302272108132253 mirMAP -0.420494750254843 0.000995090928789905 NA NA NA hsa-miR-30d-5p WNT5A -0.5492586056147 0.0140125082460125 1.41889465887496 0.00302272108132253 mirMAP -0.485615482740843 0.00175018462113529 NA NA NA hsa-miR-326 WNT5A -0.429748586406214 0.2629894124021 1.41889465887496 0.00302272108132253 miRanda -0.338021912325719 0.000172032350996894 NA NA NA hsa-miR-330-5p WNT5A 0.488365986827708 0.0512207630808233 1.41889465887496 0.00302272108132253 miRanda -0.360290139732328 0.00941314185696927 NA NA NA hsa-miR-375 WNT5A -2.94506033785642 0.00570147601654791 1.41889465887496 0.00302272108132253 miRNATAP -0.151859982937763 1.13834427953838e-06 NA NA NA hsa-miR-577 WNT5A 0.911619788986754 0.2256062124148 1.41889465887496 0.00302272108132253 mirMAP;miRNATAP -0.158155731877324 0.000655709824150159 NA NA NA hsa-miR-7-1-3p WNT5A 0.709309110750947 0.0412301737463194 1.41889465887496 0.00302272108132253 mirMAP -0.431985130260792 9.26141562033071e-06 NA NA NA