miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-199a-5p A2ML1 -0.364835768178638 0.0435119211101981 -1.64000133326521 0.000284548808469021 miRanda -0.435163518646678 6.70426976557875e-05 NA NA NA hsa-miR-199a-5p ABCA13 -0.364835768178638 0.0435119211101981 0.716895831785469 0.0847626287041009 miRanda -0.203408699942739 0.0430469600532851 NA NA NA hsa-miR-199a-5p ABI1 -0.364835768178638 0.0435119211101981 -0.23549927585078 0.00979899076835851 miRanda -0.117293446084156 6.88444750497166e-08 NA NA NA hsa-miR-148a-5p ABL2 -1.00478606532747 1.38045244999229e-07 1.09524622627639 5.63545699438722e-20 miRNATAP -0.109488303840572 8.9292837183065e-05 NA NA NA hsa-miR-30a-5p ABL2 -1.79779915425811 1.93360169837799e-26 1.09524622627639 5.63545699438722e-20 mirMAP;miRNATAP -0.180437408071179 1.90318182883753e-09 NA NA NA hsa-miR-30a-5p ACAP2 -1.79779915425811 1.93360169837799e-26 0.106346903089173 0.404271314560701 MirTarget;miRNATAP -0.101231366089478 0.00115881278371559 NA NA NA hsa-miR-199a-5p ACER2 -0.364835768178638 0.0435119211101981 -0.242169115858784 0.265521040507739 miRanda -0.225576451857189 1.51718694131891e-05 NA NA NA hsa-miR-199a-5p ACOT11 -0.364835768178638 0.0435119211101981 -0.470725426219698 0.0121497361342853 mirMAP -0.135985520476734 0.00268837107004016 NA NA NA hsa-miR-30a-5p ACTN1 -1.79779915425811 1.93360169837799e-26 0.802212932904979 9.52686781802122e-07 miRNATAP -0.2326993544286 6.11883937527359e-09 NA NA NA hsa-miR-148a-5p ACTR1A -1.00478606532747 1.38045244999229e-07 -0.0716512118537755 0.373403644319672 miRNAWalker2_validate -0.109893408832278 7.1888441216772e-10 NA NA NA hsa-miR-30a-5p ACVR1 -1.79779915425811 1.93360169837799e-26 0.698370029147071 1.58309347330158e-09 MirTarget;miRNATAP -0.177894394993838 3.53887881597698e-10 NA NA NA hsa-miR-155-5p ACVR2A 0.533437622040649 0.00248671179205372 -0.893136583106526 1.02206602554296e-15 miRNATAP -0.106267317391382 0.000157948296573559 NA NA NA hsa-miR-193b-5p ACVR2A 1.10486595354104 6.41489920661805e-11 -0.893136583106526 1.02206602554296e-15 MirTarget -0.31462426814474 1.10503938603007e-30 NA NA NA hsa-miR-155-5p ADAM10 0.533437622040649 0.00248671179205372 0.477612093001702 0.00247701484442502 miRNAWalker2_validate -0.147227063626647 0.000153673815172918 NA NA NA hsa-miR-193b-5p ADAM22 1.10486595354104 6.41489920661805e-11 -0.455391114643205 0.163329315957286 MirTarget -0.700514295143668 2.15160119120554e-18 NA NA NA hsa-miR-30a-5p ADAMTS6 -1.79779915425811 1.93360169837799e-26 2.33553865899693 2.89221078766008e-24 MirTarget;miRNATAP -0.166960506257445 0.00471024312568557 NA NA NA hsa-miR-193b-5p ADHFE1 1.10486595354104 6.41489920661805e-11 -1.99785349657953 5.7593384149715e-15 MirTarget -0.35916391597885 5.0480437649831e-08 NA NA NA hsa-miR-199a-5p ADK -0.364835768178638 0.0435119211101981 0.219197770041834 0.0377104727975009 miRanda -0.113846171900019 6.55296099973926e-06 NA NA NA hsa-miR-199a-5p ADNP2 -0.364835768178638 0.0435119211101981 -0.0512723559313599 0.621640718709248 miRanda -0.117679429935327 2.07808618950071e-06 NA NA NA hsa-miR-30a-5p AFAP1L2 -1.79779915425811 1.93360169837799e-26 1.00744032937572 3.49569167699888e-08 MirTarget;miRNATAP -0.215374474766654 1.75042443029503e-06 NA NA NA hsa-miR-148a-5p AGPAT4 -1.00478606532747 1.38045244999229e-07 0.565779019582415 0.00219417371668552 mirMAP -0.304279673786465 1.02771831630029e-13 NA NA NA hsa-miR-199a-5p AGPAT5 -0.364835768178638 0.0435119211101981 -0.0537993659017806 0.631696466783132 miRanda -0.115857082967293 1.59563461385679e-05 NA NA NA hsa-miR-155-5p AGTR1 0.533437622040649 0.00248671179205372 -1.6935484473251 2.18093931850799e-06 miRNAWalker2_validate;miRTarBase -0.374450578340668 2.3866376066798e-05 22525818 MicroRNA-155 miR-155 is one of the micro RNAs miRNA most consistently involved in neoplastic diseases and it is known to repress the angiotensin II type 1 receptor AGTR1; The aim of the present study was to evaluate the expressions of miR-155 and AGTR1 and to clarify the potential efficacy of anti-miR-155 alone and in combination with AGTR1 blocker losartan in endometrial cancers; Expressions of miR-155 and AGTR1 were evaluated using real-time PCR and immunohistochemistry; miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues; We checked that abolishing the function of miR-155 and AGTR1 by anti-miR-155 or losartan inhibited cell survival of endometrial carcinoma cells respectively and furthermore combined treatment showed synergistic effects; In this study we characterized the expressions of miR-155 and AGTR1 in endometrial tissues; The combined treatment with anti-miR-155 and losartan has a synergistic antiproliferative effect and an improved understanding is required to clarify whether miR-155 and AGTR1 can be used as a novel therapeutic target in endometrial cancer poor survival endometrial cancer hsa-miR-155-5p AHCYL2 0.533437622040649 0.00248671179205372 -0.773962729207627 1.06233586598714e-08 miRNATAP -0.11127666439925 0.000980826619107089 NA NA NA hsa-miR-30a-5p AHNAK -1.79779915425811 1.93360169837799e-26 -0.840401827878893 4.10752225267692e-08 miRNATAP -0.102396067000454 0.00711010576860337 NA NA NA hsa-miR-193b-5p AIF1L 1.10486595354104 6.41489920661805e-11 -2.24631509085545 4.38843919603074e-20 MirTarget -0.151530851201219 0.0187607520233363 NA NA NA hsa-miR-193b-5p AK3 1.10486595354104 6.41489920661805e-11 -0.846019626054023 2.00115669137351e-13 MirTarget -0.127769752243007 1.65735316723763e-05 NA NA NA hsa-miR-199a-5p AKNA -0.364835768178638 0.0435119211101981 0.230059155934164 0.109989652308392 miRanda -0.100055152636317 0.00390768496732531 NA NA NA hsa-miR-148a-5p AKR1C1 -1.00478606532747 1.38045244999229e-07 0.0112367530987845 0.977424634020327 mirMAP -0.198914261427691 0.0266341105614859 NA NA NA hsa-miR-30a-5p AKR1C1 -1.79779915425811 1.93360169837799e-26 0.0112367530987845 0.977424634020327 mirMAP -0.386237856087795 6.73599297991928e-05 NA NA NA hsa-miR-155-5p AKR1C3 0.533437622040649 0.00248671179205372 0.340314635515726 0.349289335186821 miRNAWalker2_validate -0.660045911808612 4.75772479945334e-14 NA NA NA hsa-miR-30a-5p AMMECR1 -1.79779915425811 1.93360169837799e-26 0.407110992366095 0.00380430288647156 miRNATAP -0.292712202470701 2.1372399835172e-18 NA NA NA hsa-miR-199a-5p AMPD3 -0.364835768178638 0.0435119211101981 0.0676288798591829 0.623685429198942 miRanda -0.177345612645554 6.62480257652738e-08 NA NA NA hsa-miR-148a-5p ANGPT2 -1.00478606532747 1.38045244999229e-07 1.60682659917739 3.22512104906665e-21 mirMAP -0.111398410451088 0.00531513825463852 NA NA NA hsa-miR-199a-5p ANKFY1 -0.364835768178638 0.0435119211101981 0.122969543601223 0.133807609901132 miRanda -0.102824907596142 1.37173724875228e-07 NA NA NA hsa-miR-155-5p ANKH 0.533437622040649 0.00248671179205372 0.03506906773005 0.805884124630787 mirMAP -0.125190574236085 0.000352476409936746 NA NA NA hsa-miR-199a-5p ANKRD22 -0.364835768178638 0.0435119211101981 -0.9317895923965 0.000166991556047485 miRanda -0.204276022750983 0.000651697824233715 NA NA NA hsa-miR-199a-5p ANKRD34B -0.364835768178638 0.0435119211101981 1.36917814159368 0.000788461865590885 miRanda -0.207619194186645 0.0359242365616453 NA NA NA hsa-miR-199a-5p ANKRD36B -0.364835768178638 0.0435119211101981 0.4802232713417 0.00713891061106049 miRanda -0.117090128791734 0.00663958270857693 NA NA NA hsa-miR-155-5p ANO5 0.533437622040649 0.00248671179205372 -3.22166823514355 5.56976609150319e-14 MirTarget -0.25158451336075 0.0204969473901123 NA NA NA hsa-miR-155-5p ANTXR1 0.533437622040649 0.00248671179205372 0.370286112072644 0.0299080695195914 miRNAWalker2_validate -0.144820854974962 0.000563718457328116 NA NA NA hsa-miR-155-5p AP1G1 0.533437622040649 0.00248671179205372 -0.252693889145422 0.0021324894150337 miRNAWalker2_validate -0.108354774382837 6.75786317257571e-08 NA NA NA hsa-miR-30a-5p AP4E1 -1.79779915425811 1.93360169837799e-26 0.0233284569324823 0.81318837568108 miRNATAP -0.119734804243749 5.57161543255393e-07 NA NA NA hsa-miR-30a-5p APBB2 -1.79779915425811 1.93360169837799e-26 0.870762907099259 2.68309152813562e-10 mirMAP -0.125095844472447 0.000263808435320514 NA NA NA hsa-miR-199a-5p APOL1 -0.364835768178638 0.0435119211101981 1.76100915485811 1.62048310162289e-13 miRanda -0.220418401774587 0.000179050735037037 NA NA NA hsa-miR-199a-5p APOL6 -0.364835768178638 0.0435119211101981 0.121170661203274 0.506365312077305 miRanda -0.215111741875674 7.925235171245e-07 NA NA NA hsa-miR-155-5p AR 0.533437622040649 0.00248671179205372 -3.12774628935587 7.57694225075536e-18 mirMAP -0.188275058763374 0.0426839509570087 NA NA NA hsa-miR-145-5p ARAP2 -0.46917511594055 0.000685297625493134 -0.11669256722451 0.445498836848883 MirTarget -0.180418087838782 0.000169730338620686 NA NA NA hsa-miR-145-5p ARF6 -0.46917511594055 0.000685297625493134 -0.42656469970065 2.94288025403766e-06 MirTarget -0.102288829612554 0.000396128442914943 25253741 lincRNA RoR and miR 145 regulate invasion in triple negative breast cancer via targeting ARF6 breast cancer hsa-miR-199a-5p ARF6 -0.364835768178638 0.0435119211101981 -0.42656469970065 2.94288025403766e-06 MirTarget;PITA;miRanda;miRNATAP -0.104291388762182 2.10678884588468e-06 NA NA NA hsa-miR-193b-5p ARHGAP26 1.10486595354104 6.41489920661805e-11 -0.646360551126797 0.000293256973389693 mirMAP -0.4448268004771 1.10551927552122e-24 NA NA NA hsa-miR-155-5p ARHGAP32 0.533437622040649 0.00248671179205372 -0.966409474990566 6.94779888498589e-10 mirMAP -0.178475918329474 4.80869829493802e-06 NA NA NA hsa-miR-155-5p ARHGAP5 0.533437622040649 0.00248671179205372 -0.427844756831095 0.000256069279509255 mirMAP -0.132794504085825 3.93105807613914e-06 NA NA NA hsa-miR-199a-5p ARID3B -0.364835768178638 0.0435119211101981 0.324219463844836 0.00600106486326507 miRanda -0.124560040381844 1.093310736881e-05 NA NA NA hsa-miR-155-5p ARL10 0.533437622040649 0.00248671179205372 0.0259612567234089 0.88662881481323 miRNAWalker2_validate -0.115467778193939 0.0100529048747359 NA NA NA hsa-miR-155-5p ARL15 0.533437622040649 0.00248671179205372 -0.209985524801452 0.173682665559531 miRNAWalker2_validate;miRNATAP -0.104329543973753 0.00607876693237095 NA NA NA hsa-miR-155-5p ARL2BP 0.533437622040649 0.00248671179205372 0.138901089580799 0.0664946183345271 MirTarget -0.106042957634652 7.69726034705602e-09 NA NA NA hsa-miR-145-5p ARL5B -0.46917511594055 0.000685297625493134 -0.218253113078807 0.162495913429865 MirTarget -0.127067450677452 0.0098464434262292 NA NA NA hsa-miR-199a-5p ARL6IP1 -0.364835768178638 0.0435119211101981 0.552762868684566 2.59537724020455e-12 miRanda -0.120205954837188 3.12943837449571e-10 NA NA NA hsa-miR-30a-5p ARRDC4 -1.79779915425811 1.93360169837799e-26 0.55925837432738 0.00270080276594619 mirMAP -0.258345236004254 1.18139556961973e-08 NA NA NA hsa-miR-30a-5p ASAP1 -1.79779915425811 1.93360169837799e-26 0.939773446139895 2.07462043730666e-18 miRNATAP -0.19507590187286 2.36371252455327e-13 NA NA NA hsa-miR-30a-5p ASCC3 -1.79779915425811 1.93360169837799e-26 0.140109296118495 0.200986200864867 miRNAWalker2_validate;MirTarget -0.112095890670738 2.64940072138481e-05 NA NA NA hsa-miR-155-5p ASNS 0.533437622040649 0.00248671179205372 0.754025674089294 1.01964438277724e-06 miRNAWalker2_validate -0.103861660979679 0.00685485786177591 NA NA NA hsa-miR-155-5p ASPH 0.533437622040649 0.00248671179205372 0.0309335790696945 0.801315741515798 miRNAWalker2_validate -0.116703470108797 0.000107406111996402 NA NA NA hsa-miR-30a-5p ATF2 -1.79779915425811 1.93360169837799e-26 0.104371396863857 0.473734669024994 mirMAP -0.119397648903742 0.000797054500428221 NA NA NA hsa-miR-155-5p ATF7 0.533437622040649 0.00248671179205372 -0.281513910565038 0.00177637853169439 mirMAP -0.101453250663005 4.33371308158912e-06 NA NA NA hsa-miR-30a-5p ATL3 -1.79779915425811 1.93360169837799e-26 0.292321714666651 0.027833869261757 mirMAP -0.201715219875242 3.29845769425859e-10 NA NA NA hsa-miR-199a-5p ATP10B -0.364835768178638 0.0435119211101981 -1.98904781738099 4.09003254218343e-08 miRanda -0.263530520117533 0.00292221795549028 NA NA NA hsa-miR-155-5p ATP2B1 0.533437622040649 0.00248671179205372 0.592306523211981 9.68490070521175e-06 miRNATAP -0.156771305346825 2.04900651362516e-06 NA NA NA hsa-miR-30a-5p ATP2B1 -1.79779915425811 1.93360169837799e-26 0.592306523211981 9.68490070521175e-06 MirTarget;mirMAP;miRNATAP -0.142614471642303 1.44859751512695e-05 NA NA NA hsa-miR-30a-5p ATP6V1C1 -1.79779915425811 1.93360169837799e-26 0.785880893822232 4.20368755979454e-27 miRNAWalker2_validate -0.136655770669511 9.48198598748337e-14 NA NA NA hsa-miR-155-5p ATRNL1 0.533437622040649 0.00248671179205372 -1.24855282785729 0.000648806658655108 MirTarget;mirMAP -0.354146832666211 8.90489603590937e-05 NA NA NA hsa-miR-155-5p ATXN1L 0.533437622040649 0.00248671179205372 0.0248513219040944 0.818148739112328 miRNATAP -0.118807368328944 6.84997866169982e-06 NA NA NA hsa-miR-30a-5p AVL9 -1.79779915425811 1.93360169837799e-26 0.234729386140587 0.0153472888948578 MirTarget;mirMAP;miRNATAP -0.188559725605852 2.97233364338262e-16 NA NA NA hsa-miR-199a-5p B3GNT3 -0.364835768178638 0.0435119211101981 -0.551074217043873 0.0477849562641209 miRanda -0.368266322664456 3.01871456671697e-08 NA NA NA hsa-miR-30a-5p B3GNT5 -1.79779915425811 1.93360169837799e-26 0.310545272797327 0.0534328831295295 MirTarget;miRNATAP -0.325104710538453 1.87210438513275e-17 NA NA NA hsa-miR-199a-5p BACH1 -0.364835768178638 0.0435119211101981 0.0188890691942154 0.884422593387864 miRanda -0.157058559522476 4.04090972567316e-07 NA NA NA hsa-miR-30a-5p BACH1 -1.79779915425811 1.93360169837799e-26 0.0188890691942154 0.884422593387864 miRNATAP -0.168080468450741 9.284928709101e-08 NA NA NA hsa-miR-30a-5p BAG4 -1.79779915425811 1.93360169837799e-26 0.0959554180881805 0.551978994285614 mirMAP -0.12550660353833 0.00146579973017378 NA NA NA hsa-miR-155-5p BAG5 0.533437622040649 0.00248671179205372 -0.328156126771955 1.59951594573373e-06 miRNAWalker2_validate -0.105697070021685 2.31808168626268e-10 NA NA NA hsa-miR-30a-5p BCL11B -1.79779915425811 1.93360169837799e-26 0.599657272518217 0.000311218466785005 miRNATAP -0.324009784101129 4.24071599463125e-16 NA NA NA hsa-miR-155-5p BCL6 0.533437622040649 0.00248671179205372 -0.429231746891183 0.000388543290392709 miRNAWalker2_validate;miRTarBase -0.146049124679741 8.78043013230214e-07 23169640 We show that Bcl6 is indirectly regulated by miR-155 through Mxd1/Mad1 up-regulation; Interestingly we found that miR-155 directly targets HDAC4 a corepressor partner of BCL6; Meta-analysis of the diffuse large B-cell lymphoma patient microarray data showed that miR-155 expression is inversely correlated with Bcl6 and Hdac4; Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias poor survival B cell lymphoma hsa-miR-155-5p BCORL1 0.533437622040649 0.00248671179205372 0.352716639567579 0.00449537104175828 MirTarget -0.207314714967063 5.50165306630888e-12 NA NA NA hsa-miR-155-5p BDNF 0.533437622040649 0.00248671179205372 0.0408778714112631 0.883450816679916 miRNATAP -0.22678558150571 0.000944767256917019 NA NA NA hsa-miR-193b-5p BEND7 1.10486595354104 6.41489920661805e-11 -1.92595717226537 5.21741008098439e-13 mirMAP -0.594596994389318 5.98825656663462e-19 NA NA NA hsa-miR-148a-5p BICD1 -1.00478606532747 1.38045244999229e-07 1.52724764036632 5.31292483276806e-19 mirMAP -0.108030333846734 0.00713606475387366 NA NA NA hsa-miR-30a-5p BICD1 -1.79779915425811 1.93360169837799e-26 1.52724764036632 5.31292483276806e-19 mirMAP -0.253879098077606 3.626379850519e-09 NA NA NA hsa-miR-148a-5p BICD2 -1.00478606532747 1.38045244999229e-07 0.462371809305901 0.000541667078720085 mirMAP -0.11749874268711 9.91209876253327e-05 NA NA NA hsa-miR-199a-5p BLK -0.364835768178638 0.0435119211101981 0.523024004244954 0.18133115261703 miRanda -0.188926436455392 0.0456620698386587 NA NA NA hsa-miR-30a-5p BNC1 -1.79779915425811 1.93360169837799e-26 1.77927417963246 1.98262556838681e-12 MirTarget;miRNATAP -0.667904241482356 9.86904036703681e-29 NA NA NA hsa-miR-155-5p BOC 0.533437622040649 0.00248671179205372 -2.04245777378377 2.61510379495177e-24 MirTarget -0.107703066901481 0.0383109830276427 NA NA NA hsa-miR-199a-5p BRCA1 -0.364835768178638 0.0435119211101981 1.08313397059632 2.93590901543702e-18 miRanda -0.212781521204852 2.53770827236802e-12 NA NA NA hsa-miR-155-5p BRD1 0.533437622040649 0.00248671179205372 -0.19251642269164 0.0133070972587333 MirTarget -0.10249301768011 6.18419008785897e-08 NA NA NA hsa-miR-155-5p BRWD3 0.533437622040649 0.00248671179205372 -0.214542308241326 0.204419111552973 miRNATAP -0.121276499014365 0.00358239647782779 NA NA NA hsa-miR-30a-5p BRWD3 -1.79779915425811 1.93360169837799e-26 -0.214542308241326 0.204419111552973 MirTarget;miRNATAP -0.121410424887105 0.00336132489616086 NA NA NA hsa-miR-143-5p BSPRY 0.502923736905281 0.00432190530694735 -2.09961009838151 2.5175340523953e-12 MirTarget -0.318303514780073 2.3808089955257e-05 NA NA NA hsa-miR-199a-5p BSPRY -0.364835768178638 0.0435119211101981 -2.09961009838151 2.5175340523953e-12 miRanda -0.304850276947728 3.44907191087924e-05 NA NA NA hsa-miR-30a-5p BTBD7 -1.79779915425811 1.93360169837799e-26 -0.00212249331540093 0.982444391407788 miRNATAP -0.13546474307931 5.84453378478047e-09 NA NA NA hsa-miR-139-5p BUB1 -1.46099200329485 7.85040381494472e-22 1.79401606733955 3.40093824308439e-38 miRanda -0.28867794910836 8.65970366136342e-13 NA NA NA hsa-miR-199a-5p BUB1 -0.364835768178638 0.0435119211101981 1.79401606733955 3.40093824308439e-38 miRanda -0.191892964912779 7.99367483200517e-08 NA NA NA hsa-miR-199b-5p BUB1 -1.08432682485992 7.68241801134089e-10 1.79401606733955 3.40093824308439e-38 miRanda -0.227928219031319 2.12371211849233e-10 NA NA NA hsa-miR-495-3p BUB1 -1.47803501311999 6.88839745293927e-13 1.79401606733955 3.40093824308439e-38 MirTarget -0.203184632032314 2.86042778161751e-11 NA NA NA hsa-miR-653-5p BUB1 -1.04995590592975 8.04165192833917e-08 1.79401606733955 3.40093824308439e-38 MirTarget -0.19590091174433 2.194521222695e-09 NA NA NA hsa-miR-155-5p C16orf87 0.533437622040649 0.00248671179205372 0.372679066575782 0.000127582997738448 mirMAP -0.102512979771436 1.8603103798728e-05 NA NA NA hsa-miR-30a-5p C16orf87 -1.79779915425811 1.93360169837799e-26 0.372679066575782 0.000127582997738448 miRNATAP -0.114705215656807 1.37441444699549e-06 NA NA NA hsa-miR-30a-5p C6orf132 -1.79779915425811 1.93360169837799e-26 -1.1157344106943 1.07625828787474e-10 mirMAP -0.111395296258466 0.00988390341108336 NA NA NA hsa-miR-30a-5p C7orf43 -1.79779915425811 1.93360169837799e-26 0.378370822015197 2.07774445657159e-06 miRNATAP -0.114451868454061 3.69547706696947e-09 NA NA NA hsa-miR-148a-5p CA12 -1.00478606532747 1.38045244999229e-07 0.0674747456932687 0.782711581719948 MirTarget -0.232106878523462 2.38410381436284e-05 NA NA NA hsa-miR-199a-5p CALB1 -0.364835768178638 0.0435119211101981 4.39773196682104 1.79241886089056e-12 miRanda -0.35311506126845 0.0219317950530773 NA NA NA hsa-miR-30a-5p CALB2 -1.79779915425811 1.93360169837799e-26 -0.399190380805789 0.2577421747978 miRNATAP -0.262526249534788 0.00237948363605208 NA NA NA hsa-miR-155-5p CALU 0.533437622040649 0.00248671179205372 0.939905146742839 1.91517392012572e-14 miRNAWalker2_validate -0.176126558903476 9.38324837837677e-09 NA NA NA hsa-miR-30a-5p CALU -1.79779915425811 1.93360169837799e-26 0.939905146742839 1.91517392012572e-14 MirTarget -0.100175914427027 0.00115732660505461 NA NA NA hsa-miR-30a-5p CAND1 -1.79779915425811 1.93360169837799e-26 0.354055271809521 0.000160619358778213 mirMAP -0.142249571099723 3.8740124131004e-10 NA NA NA hsa-miR-30a-5p CAPZA1 -1.79779915425811 1.93360169837799e-26 0.22500513037027 0.0127269220207842 MirTarget;miRNATAP -0.131140362391123 1.85921683696117e-09 NA NA NA hsa-miR-155-5p CARD10 0.533437622040649 0.00248671179205372 0.623445032143018 0.000704663090995316 MirTarget -0.124143913189782 0.00644264396480838 NA NA NA hsa-miR-145-5p CASP10 -0.46917511594055 0.000685297625493134 0.039121225798822 0.788947657309733 mirMAP -0.212338082257249 3.32413954629936e-06 NA NA NA hsa-miR-199a-5p CASP4 -0.364835768178638 0.0435119211101981 -0.165207959462718 0.267985868215923 miRanda -0.129448441789796 0.000302458802919992 NA NA NA hsa-miR-193b-5p CBFA2T2 1.10486595354104 6.41489920661805e-11 0.198268842384436 0.0584060645349655 mirMAP -0.156446527731066 2.13289553731816e-09 NA NA NA hsa-miR-193b-5p CBFA2T3 1.10486595354104 6.41489920661805e-11 -0.34106566364742 0.0812106152041786 mirMAP -0.178905343244638 0.00029276402676016 NA NA NA hsa-miR-199a-5p CBL -0.364835768178638 0.0435119211101981 0.362857804430257 0.0025244127412177 MirTarget;PITA;miRNATAP -0.118006281256044 4.43311992589427e-05 NA NA NA hsa-miR-30a-5p CBLB -1.79779915425811 1.93360169837799e-26 1.00001735532555 2.84951349498502e-16 MirTarget -0.154069724827595 4.8078745582151e-07 NA NA NA hsa-miR-30a-5p CBX2 -1.79779915425811 1.93360169837799e-26 1.47681212817303 1.07888432852792e-15 miRNATAP -0.334026619036427 2.07632863450724e-13 NA NA NA hsa-miR-199a-5p CCDC15 -0.364835768178638 0.0435119211101981 0.193377373075106 0.0853125366196594 miRanda -0.15640979605912 4.81607913092798e-09 NA NA NA hsa-miR-199a-5p CCDC88C -0.364835768178638 0.0435119211101981 0.109320261041479 0.423193991365649 PITA;miRanda;miRNATAP -0.108508063956326 0.000940634130086944 NA NA NA hsa-miR-33a-5p CCL5 1.12988965056352 3.35742517382153e-07 1.31365706816557 1.02361353980496e-06 MirTarget -0.228728415116677 1.34322758088086e-05 NA NA NA hsa-miR-30a-5p CCNA1 -1.79779915425811 1.93360169837799e-26 1.54036441608558 0.00197491909859988 MirTarget -0.476840275421781 9.41877573955024e-05 NA NA NA hsa-miR-199a-5p CCNA2 -0.364835768178638 0.0435119211101981 1.57175220032307 1.1085221982606e-28 miRanda -0.209426529667421 4.0939114925222e-09 NA NA NA hsa-miR-155-5p CCND1 0.533437622040649 0.00248671179205372 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.205881873012998 0.000104382699617692 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-30a-5p CCNE2 -1.79779915425811 1.93360169837799e-26 1.23951713462192 5.15429419774609e-15 miRNATAP -0.160843483864371 5.22163952330061e-05 NA NA NA hsa-miR-148a-5p CD109 -1.00478606532747 1.38045244999229e-07 1.06941457006724 7.27442991302339e-12 mirMAP -0.105252465726036 0.00342519066569002 NA NA NA hsa-miR-155-5p CD109 0.533437622040649 0.00248671179205372 1.06941457006724 7.27442991302339e-12 miRNAWalker2_validate -0.184143264362082 2.35329346721195e-06 NA NA NA hsa-miR-155-5p CD36 0.533437622040649 0.00248671179205372 -1.16973834444081 4.34402527008477e-05 miRNAWalker2_validate -0.325395459148946 4.03426468410576e-06 NA NA NA hsa-miR-148a-5p CD44 -1.00478606532747 1.38045244999229e-07 0.514048594063278 6.76874484016064e-05 mirMAP -0.115480139810636 7.57127698252041e-05 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity liver cancer hsa-miR-30a-5p CD44 -1.79779915425811 1.93360169837799e-26 0.514048594063278 6.76874484016064e-05 miRNAWalker2_validate -0.225182101899925 4.74750482420153e-13 NA NA NA hsa-miR-145-5p CD47 -0.46917511594055 0.000685297625493134 0.425223426005942 0.00074814900128696 miRNATAP -0.150073742485364 0.000159449003516141 NA NA NA hsa-miR-30a-5p CDC20 -1.79779915425811 1.93360169837799e-26 1.92394871207273 1.16026891464671e-36 miRNAWalker2_validate -0.273923582976354 3.3579001923132e-12 NA NA NA hsa-miR-155-5p CDC42BPB 0.533437622040649 0.00248671179205372 0.0475060735827295 0.624704962042275 miRNAWalker2_validate -0.174786091298955 6.58730731757856e-14 NA NA NA hsa-miR-199a-5p CDC6 -0.364835768178638 0.0435119211101981 1.921819057412 2.04938004906943e-42 miRanda -0.171982657004893 2.77828416080196e-06 NA NA NA hsa-miR-199a-5p CDC7 -0.364835768178638 0.0435119211101981 1.02536143134453 3.61024125314521e-14 MirTarget;miRanda -0.171705224670632 2.25957911872273e-07 NA NA NA hsa-miR-30a-5p CDCP1 -1.79779915425811 1.93360169837799e-26 0.175042066093257 0.223851961796584 miRNAWalker2_validate -0.233230561599893 1.60738600953533e-11 NA NA NA hsa-miR-199a-5p CDH1 -0.364835768178638 0.0435119211101981 -0.12671230350084 0.468601955580465 MirTarget;miRanda -0.178738126529922 1.98814329773256e-05 25080937 In contrast inhibition of miR-199a-5p impaired the metastatic potential of GC cells in vitro and in vivo and E-cadherin was identified as a direct and functional target of miR-199a-5p in GC cells gastric cancer hsa-miR-155-5p CDH13 0.533437622040649 0.00248671179205372 0.415248595175793 0.0612629088266989 miRNAWalker2_validate -0.334210932696024 5.80602601799473e-10 NA NA NA hsa-miR-30a-5p CDK12 -1.79779915425811 1.93360169837799e-26 0.311738442245723 0.000761864648754776 MirTarget;miRNATAP -0.171487779713179 1.07643481281573e-14 NA NA NA hsa-miR-148a-5p CDK6 -1.00478606532747 1.38045244999229e-07 0.943799976100438 3.26010908820164e-07 mirMAP -0.168311831982054 6.19585640247235e-05 NA NA NA hsa-miR-30a-5p CDK6 -1.79779915425811 1.93360169837799e-26 0.943799976100438 3.26010908820164e-07 mirMAP -0.244091558945119 7.330875395431e-08 NA NA NA hsa-miR-155-5p CDS1 0.533437622040649 0.00248671179205372 -0.625951146351938 2.46312534738492e-06 miRNATAP -0.133433945894175 4.99652213502002e-05 NA NA NA hsa-miR-193b-5p CEACAM5 1.10486595354104 6.41489920661805e-11 -3.1417461175956 1.75093029357331e-09 MirTarget -0.928828150792452 1.74859514842616e-12 NA NA NA hsa-miR-30a-5p CELSR3 -1.79779915425811 1.93360169837799e-26 2.17631508141994 2.51063350296877e-18 MirTarget;miRNATAP -0.282908537768 6.8929973635598e-06 NA NA NA hsa-miR-199a-5p CENPA -0.364835768178638 0.0435119211101981 2.21026448140015 1.40588848674379e-50 miRanda -0.145912979565834 0.000206664732791977 NA NA NA hsa-miR-139-5p CENPF -1.46099200329485 7.85040381494472e-22 1.74222676468191 1.05826223571311e-29 miRanda -0.308476596158013 2.44027783023278e-12 NA NA NA hsa-miR-338-5p CENPF -1.71946558699173 2.62649071488641e-23 1.74222676468191 1.05826223571311e-29 MirTarget -0.135130754694087 0.000579760876739266 NA NA NA hsa-miR-101-3p CENPO -1.91263766544878 1.50270129259053e-39 1.42038960635 3.49606309115155e-37 mirMAP -0.178895756446388 5.70548205703093e-08 NA NA NA hsa-miR-10b-5p CENPO -0.582989331935508 4.56688330655626e-06 1.42038960635 3.49606309115155e-37 mirMAP -0.168920053347294 3.37158889773137e-05 NA NA NA hsa-miR-125b-5p CENPO -0.993460109818276 5.07736727659894e-12 1.42038960635 3.49606309115155e-37 mirMAP -0.141951069135932 6.39682255272097e-05 NA NA NA hsa-miR-338-3p CENPO -0.948755228846395 8.99167125682392e-08 1.42038960635 3.49606309115155e-37 miRanda -0.120040305613687 3.43626631415841e-05 NA NA NA hsa-miR-30a-5p CEP72 -1.79779915425811 1.93360169837799e-26 1.03841619380742 1.78804832989906e-16 miRNAWalker2_validate -0.119105328250693 0.000176155775787486 NA NA NA hsa-miR-145-5p CEP78 -0.46917511594055 0.000685297625493134 0.616107592019814 2.87731408317344e-09 mirMAP -0.137855324726322 2.92796637894554e-05 NA NA NA hsa-miR-199a-5p CGN -0.364835768178638 0.0435119211101981 -1.91422640703812 6.70219489299859e-14 miRanda -0.174400587296139 0.00578782429963852 NA NA NA hsa-miR-145-5p CHAC2 -0.46917511594055 0.000685297625493134 0.240021419844036 0.0780040049494493 MirTarget -0.112582756655288 0.00869613153411771 NA NA NA hsa-miR-199a-5p CHD1 -0.364835768178638 0.0435119211101981 -0.0494210874842338 0.590564532512215 miRanda -0.100699453982345 4.36634792168507e-06 NA NA NA hsa-miR-155-5p CHD9 0.533437622040649 0.00248671179205372 -0.333365447561365 0.00383634272559432 miRNAWalker2_validate -0.142578893787702 4.38181465951716e-07 NA NA NA hsa-miR-139-5p CHEK1 -1.46099200329485 7.85040381494472e-22 1.20396859855604 7.17975286300605e-27 miRanda -0.178007141307805 3.06480379143231e-08 NA NA NA hsa-miR-195-5p CHEK1 -1.8367376818177 6.9944883988895e-31 1.20396859855604 7.17975286300605e-27 MirTarget;miRNATAP -0.174259778110084 7.35654556791948e-09 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-495-3p CHEK1 -1.47803501311999 6.88839745293927e-13 1.20396859855604 7.17975286300605e-27 MirTarget -0.100625603739772 3.70483806389657e-05 NA NA NA hsa-miR-497-5p CHEK1 -0.966244470847844 5.26505649147857e-12 1.20396859855604 7.17975286300605e-27 MirTarget;miRNATAP -0.141727865552293 8.05919355042318e-05 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-193b-5p CHRDL1 1.10486595354104 6.41489920661805e-11 -4.43407568828776 8.98145290020417e-21 MirTarget -1.07472205957679 6.1871643789424e-19 NA NA NA hsa-miR-30a-5p CHST1 -1.79779915425811 1.93360169837799e-26 1.1574356869764 2.62223752001215e-06 MirTarget -0.195861823545249 0.00129961604056486 NA NA NA hsa-miR-30a-5p CHST2 -1.79779915425811 1.93360169837799e-26 2.62035179914324 8.99320571460582e-24 MirTarget;miRNATAP -0.563085031044121 3.85688220245627e-18 NA NA NA hsa-miR-30a-5p CIT -1.79779915425811 1.93360169837799e-26 1.10343571346107 2.13038528533094e-15 miRNATAP -0.100683387353437 0.00407565425535921 NA NA NA hsa-miR-143-5p CITED2 0.502923736905281 0.00432190530694735 -1.19411739991374 1.42032651599937e-15 miRNATAP -0.101802040608456 0.007371001551109 NA NA NA hsa-miR-30a-5p CLCF1 -1.79779915425811 1.93360169837799e-26 0.647967436771911 0.00137053013714127 miRNATAP -0.148783206051653 0.00280500455156757 NA NA NA hsa-miR-155-5p CLDN8 0.533437622040649 0.00248671179205372 -4.50513642186071 3.34157147733008e-17 MirTarget -0.560033422078658 3.58596070333621e-05 NA NA NA hsa-miR-193b-5p CLIP3 1.10486595354104 6.41489920661805e-11 0.368796405481798 0.0565861905298717 MirTarget -0.142817790957237 0.00354434705312509 NA NA NA hsa-miR-148a-5p CLNS1A -1.00478606532747 1.38045244999229e-07 0.248510421673337 0.0109998139811805 MirTarget -0.107473265662763 9.10066436318832e-07 NA NA NA hsa-miR-155-5p CLTC 0.533437622040649 0.00248671179205372 0.134360348581453 0.0818947428550757 miRNAWalker2_validate -0.107454980576949 9.80801240642315e-09 NA NA NA hsa-miR-30a-5p CLTC -1.79779915425811 1.93360169837799e-26 0.134360348581453 0.0818947428550757 mirMAP -0.138797861784074 4.96592919289287e-14 NA NA NA hsa-miR-199a-5p CMPK2 -0.364835768178638 0.0435119211101981 1.4843128569362 5.10424230928364e-09 miRanda -0.275810956411654 8.16135900634998e-06 NA NA NA hsa-miR-145-5p CNDP2 -0.46917511594055 0.000685297625493134 -0.0329627636451537 0.782671609763192 MirTarget -0.161466681118521 1.55221351783551e-05 NA NA NA hsa-miR-193b-5p CNIH3 1.10486595354104 6.41489920661805e-11 1.30525849697765 4.74597851993424e-07 MirTarget -0.130723383669637 0.0492174882755521 NA NA NA hsa-miR-148a-5p CNIH4 -1.00478606532747 1.38045244999229e-07 0.416492349156748 2.52098744664575e-09 mirMAP -0.115326794960509 1.41613824843897e-13 NA NA NA hsa-miR-30a-5p CNOT6 -1.79779915425811 1.93360169837799e-26 0.214135288211322 0.014233036293575 MirTarget -0.104530138852707 8.3725205261951e-07 NA NA NA hsa-miR-155-5p COBLL1 0.533437622040649 0.00248671179205372 -0.560455837736872 0.000398176823298625 mirMAP -0.155187267603433 7.03445442315804e-05 NA NA NA hsa-miR-30a-5p COBLL1 -1.79779915425811 1.93360169837799e-26 -0.560455837736872 0.000398176823298625 mirMAP -0.182987778080624 2.26264108844388e-06 NA NA NA hsa-miR-30a-5p COL12A1 -1.79779915425811 1.93360169837799e-26 2.79108836051808 1.21317193345327e-27 mirMAP -0.462488555743646 1.11862242332769e-12 NA NA NA hsa-miR-30a-5p COL13A1 -1.79779915425811 1.93360169837799e-26 2.70590554315928 1.03430650556975e-43 miRNATAP -0.266993193882317 2.51098629258296e-07 NA NA NA hsa-miR-148a-5p COL5A2 -1.00478606532747 1.38045244999229e-07 3.09409293887095 7.44408155884721e-31 MirTarget -0.29839813949196 3.01718422011844e-06 NA NA NA hsa-miR-30a-5p CORO1C -1.79779915425811 1.93360169837799e-26 0.627594525272486 4.11571051366977e-11 miRNAWalker2_validate -0.216105862474182 2.74033429375196e-21 NA NA NA hsa-miR-199a-5p CORO2A -0.364835768178638 0.0435119211101981 0.282818446568188 0.0509750062657031 MirTarget -0.171943844622465 7.01011114759001e-07 NA NA NA hsa-miR-30a-5p CPEB2 -1.79779915425811 1.93360169837799e-26 -0.584354467110987 0.000658520044567338 mirMAP;miRNATAP -0.132558240262501 0.00167742258775912 NA NA NA hsa-miR-155-5p CPEB4 0.533437622040649 0.00248671179205372 -1.56444910002595 1.36952668225952e-21 mirMAP -0.144890126558119 0.000567547635745838 NA NA NA hsa-miR-30a-5p CPNE8 -1.79779915425811 1.93360169837799e-26 0.566372934160522 0.000967752700101928 miRNAWalker2_validate;MirTarget;miRNATAP -0.180362877339613 1.77140355087435e-05 NA NA NA hsa-miR-155-5p CPT1A 0.533437622040649 0.00248671179205372 -0.0675460021751624 0.671958682337183 miRNAWalker2_validate -0.151745965914122 0.00010533789226584 NA NA NA hsa-miR-30a-5p CRK -1.79779915425811 1.93360169837799e-26 -0.0814815970417762 0.345915316348875 miRNATAP -0.114904019363501 3.76048741711619e-08 NA NA NA hsa-miR-30a-5p CRKL -1.79779915425811 1.93360169837799e-26 0.528918151929006 5.6460064779249e-08 MirTarget;mirMAP;miRNATAP -0.194237239802538 1.19884840461708e-16 NA NA NA hsa-miR-30a-5p CSMD3 -1.79779915425811 1.93360169837799e-26 1.73647585708214 4.25069072534188e-05 MirTarget -0.253263720509131 0.0157306220786289 NA NA NA hsa-miR-30a-5p CSNK1A1 -1.79779915425811 1.93360169837799e-26 -0.0678841653273512 0.477676331500234 MirTarget;miRNATAP -0.154112018482441 1.87051174955458e-11 NA NA NA hsa-miR-148a-5p CSNK1E -1.00478606532747 1.38045244999229e-07 0.548936364081841 1.10720819240592e-10 miRNATAP -0.116497957841565 1.41533291460369e-09 NA NA NA hsa-miR-30a-5p CSNK1G1 -1.79779915425811 1.93360169837799e-26 0.206448152308607 0.0126562525934027 miRNAWalker2_validate;MirTarget;mirMAP -0.132951319060662 2.44285687343397e-11 NA NA NA hsa-miR-199a-5p CSTF2 -0.364835768178638 0.0435119211101981 -0.0650538984072639 0.458889181630648 miRanda -0.137575671017793 3.22180542246063e-11 NA NA NA hsa-miR-30a-5p CTHRC1 -1.79779915425811 1.93360169837799e-26 3.40477771423069 4.66292028528871e-38 MirTarget -0.254457920406936 0.000260419020227386 NA NA NA hsa-miR-145-5p CTNND1 -0.46917511594055 0.000685297625493134 -0.244832796400551 0.0276328020341148 miRNATAP -0.14380227784879 3.69703839411836e-05 25470111 Luciferase assay western blot analysis and in vivo assays were used to determine whether CTNND1 could be regulated by miR-145; CTNND1 was proved to be a direct target gene for miR-145 gastric cancer hsa-miR-30a-5p CTNND1 -1.79779915425811 1.93360169837799e-26 -0.244832796400551 0.0276328020341148 miRNAWalker2_validate -0.110161897811351 4.88381379774021e-05 NA NA NA hsa-miR-199a-5p CTTNBP2NL -0.364835768178638 0.0435119211101981 -0.287694040572116 0.0068715005187631 MirTarget;miRanda -0.10116498132086 7.64723968756157e-05 NA NA NA hsa-miR-155-5p CUX1 0.533437622040649 0.00248671179205372 -0.0365577333449663 0.708992309183929 miRNAWalker2_validate -0.147978839141819 4.36257920652551e-10 NA NA NA hsa-miR-155-5p CYB561D1 0.533437622040649 0.00248671179205372 -0.489476032151862 3.46533503819344e-06 miRNATAP -0.101132619130181 0.000106676726484081 NA NA NA hsa-miR-199a-5p CYB5R2 -0.364835768178638 0.0435119211101981 0.442944763544848 0.0167313434572713 miRanda -0.107763388384403 0.0160194884447849 NA NA NA hsa-miR-155-5p CYP51A1 0.533437622040649 0.00248671179205372 -0.125623994807362 0.350681288979637 miRNAWalker2_validate -0.170705096598419 1.99422806659467e-07 NA NA NA hsa-miR-155-5p CYR61 0.533437622040649 0.00248671179205372 -0.567354951819466 0.00417908418096135 miRNAWalker2_validate;miRTarBase -0.167937445498313 0.000589988963654811 NA NA NA hsa-miR-30a-5p DARS2 -1.79779915425811 1.93360169837799e-26 0.625638024391954 1.41667265688432e-10 miRNAWalker2_validate -0.1418262888234 3.37525550609916e-09 NA NA NA hsa-miR-199a-5p DBF4 -0.364835768178638 0.0435119211101981 0.955563441597312 2.44873116744695e-18 miRanda -0.113349676736592 2.96818548836417e-05 NA NA NA hsa-miR-30a-5p DBF4 -1.79779915425811 1.93360169837799e-26 0.955563441597312 2.44873116744695e-18 MirTarget -0.135306810751893 8.73411924668954e-07 NA NA NA hsa-miR-155-5p DBN1 0.533437622040649 0.00248671179205372 0.446220425959994 0.000566552848445038 miRNAWalker2_validate -0.117565392593841 0.000232196636799768 NA NA NA hsa-miR-155-5p DDI2 0.533437622040649 0.00248671179205372 -0.815704602099553 0.00210424494160328 mirMAP -0.149782804798184 0.0226570546571629 NA NA NA hsa-miR-30a-5p DDIT4 -1.79779915425811 1.93360169837799e-26 0.970744345695446 1.21158401060779e-06 MirTarget;miRNATAP -0.154401827902412 0.00180557215482945 NA NA NA hsa-miR-199a-5p DDX21 -0.364835768178638 0.0435119211101981 -0.0396142672597719 0.81656270293234 miRanda -0.158447325271119 0.000110239091649525 NA NA NA hsa-miR-199a-5p DDX58 -0.364835768178638 0.0435119211101981 1.21832348385351 6.63889893025311e-10 miRanda -0.256763906305728 8.3302426026299e-08 NA NA NA hsa-miR-199a-5p DDX60 -0.364835768178638 0.0435119211101981 1.49907398815303 3.68937455001163e-10 miRanda -0.269221132985244 3.91901711009424e-06 NA NA NA hsa-miR-199a-5p DEK -0.364835768178638 0.0435119211101981 0.617051536463888 1.19429232244745e-10 miRanda -0.123406771680148 1.11004982649692e-07 NA NA NA hsa-miR-30a-5p DENND1B -1.79779915425811 1.93360169837799e-26 -0.28535443757028 0.0516173108154059 mirMAP -0.183657833972626 2.52769239467348e-07 NA NA NA hsa-miR-199a-5p DEPDC1B -0.364835768178638 0.0435119211101981 1.86235686239792 3.80214808879393e-34 PITA;miRanda -0.232632649169865 2.25548838704054e-09 NA NA NA hsa-miR-30a-5p DERL1 -1.79779915425811 1.93360169837799e-26 0.554149563365506 2.53911350437083e-17 miRNAWalker2_validate -0.102679674399294 2.53622367480035e-10 NA NA NA hsa-miR-155-5p DGKG 0.533437622040649 0.00248671179205372 0.862237626636469 0.00337647445781197 mirMAP -0.144029111733001 0.0481824020370134 NA NA NA hsa-miR-30a-5p DGKH -1.79779915425811 1.93360169837799e-26 0.251379078709298 0.108034967471405 MirTarget -0.238222082877835 2.78663666432567e-10 NA NA NA hsa-miR-30a-5p DHX33 -1.79779915425811 1.93360169837799e-26 0.116959592401434 0.526781487205797 miRNAWalker2_validate -0.150456618123524 0.000868278027881768 NA NA NA hsa-miR-30a-5p DHX36 -1.79779915425811 1.93360169837799e-26 0.512448521577868 5.94219482351999e-08 miRNAWalker2_validate -0.140621227319045 1.1336347709373e-09 NA NA NA hsa-miR-199a-5p DIAPH3 -0.364835768178638 0.0435119211101981 1.23154545244588 2.64298495030277e-18 miRanda -0.152925597115861 1.26095046365131e-05 NA NA NA hsa-miR-30a-5p DIP2B -1.79779915425811 1.93360169837799e-26 0.4337725234097 0.000724913770858042 MirTarget;miRNATAP -0.284566123088581 7.84023846357588e-21 NA NA NA hsa-miR-155-5p DIXDC1 0.533437622040649 0.00248671179205372 -0.816503854402675 6.4309930074914e-07 MirTarget -0.134860585655496 0.000947341179328413 NA NA NA hsa-miR-193b-5p DMD 1.10486595354104 6.41489920661805e-11 -1.6290568204213 3.3814878939272e-10 MirTarget;miRNATAP -0.210564664449233 0.00161444171476724 NA NA NA hsa-miR-199a-5p DOCK9 -0.364835768178638 0.0435119211101981 -0.931741165518727 4.28701454841643e-11 miRanda -0.109021664211251 0.00166851573527366 NA NA NA hsa-miR-30a-5p DOLPP1 -1.79779915425811 1.93360169837799e-26 0.407282965464471 1.30762257395338e-06 MirTarget;miRNATAP -0.104281450704617 4.12882465364629e-07 NA NA NA hsa-miR-155-5p DPP8 0.533437622040649 0.00248671179205372 -0.408837635380773 0.00418269757652322 mirMAP -0.175865324207529 4.93698520028116e-07 NA NA NA hsa-miR-193b-5p DPYSL5 1.10486595354104 6.41489920661805e-11 -0.393407893182862 0.306034560058544 MirTarget -0.361096343387173 0.000197044867110042 NA NA NA hsa-miR-155-5p DSG2 0.533437622040649 0.00248671179205372 1.16352585529849 3.78339237358084e-10 miRNAWalker2_validate -0.215335091726093 3.30291073810269e-06 NA NA NA hsa-miR-30a-5p DSG2 -1.79779915425811 1.93360169837799e-26 1.16352585529849 3.78339237358084e-10 miRNAWalker2_validate;MirTarget -0.182879508018776 7.46136034744508e-05 NA NA NA hsa-miR-30a-5p DSP -1.79779915425811 1.93360169837799e-26 -0.097806766585979 0.653845718555469 MirTarget -0.345840917849562 4.56666434692004e-11 NA NA NA hsa-miR-30a-5p DTL -1.79779915425811 1.93360169837799e-26 1.9093127839283 5.8618344366915e-39 miRNAWalker2_validate;miRTarBase -0.227614865945918 2.63438647149461e-09 22287560 MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL; Subsequent reporter gene assays confirmed the predicted miR-30a-5p binding site in the 3'untranslated region of DTL; In conclusion our data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression which is frequently overexpressed in colorectal cancer colon cancer hsa-miR-199a-5p DUOX2 -0.364835768178638 0.0435119211101981 -1.14508030616514 0.000364440728425784 miRanda -0.304653397937701 8.60773973671399e-05 NA NA NA hsa-miR-199a-5p DUSP4 -0.364835768178638 0.0435119211101981 -0.561851288273301 0.00782378661650914 miRanda -0.184853086629782 0.000283095105782761 NA NA NA hsa-miR-155-5p DYNC1I1 0.533437622040649 0.00248671179205372 -0.106479403668793 0.766963994131167 MirTarget;miRNATAP -0.574369958814834 4.13067386323493e-11 NA NA NA hsa-miR-155-5p DYNC2H1 0.533437622040649 0.00248671179205372 -0.333778413266954 0.0772984015623819 miRNAWalker2_validate -0.222676088448538 1.47572133418589e-06 NA NA NA hsa-miR-30a-5p E2F7 -1.79779915425811 1.93360169837799e-26 2.22242579740507 4.78388281129068e-31 miRNATAP -0.308184682220767 3.96646803224832e-10 NA NA NA hsa-miR-30a-5p EAF1 -1.79779915425811 1.93360169837799e-26 -0.29521033232646 0.00433401452666593 MirTarget;miRNATAP -0.11928793604851 2.22831419389862e-06 NA NA NA hsa-miR-155-5p EBF2 0.533437622040649 0.00248671179205372 -0.686471255666013 0.0222350177502073 mirMAP -0.256200362783916 0.000536148225478375 NA NA NA hsa-miR-140-5p ECT2 -0.412389003031485 0.000136051708543369 1.54998346952164 5.69454537791983e-27 miRanda -0.179266585143713 0.0034716802477504 NA NA NA hsa-miR-26b-5p ECT2 -0.254478038884324 0.0285227763044636 1.54998346952164 5.69454537791983e-27 miRNAWalker2_validate -0.203695332517567 0.000363021179960477 NA NA NA hsa-miR-30c-5p ECT2 0.021222006155897 0.886366656528128 1.54998346952164 5.69454537791983e-27 miRNAWalker2_validate -0.149518156494057 0.00081594547120416 NA NA NA hsa-miR-664a-3p ECT2 -0.256108763664991 0.0513188660751664 1.54998346952164 5.69454537791983e-27 MirTarget;mirMAP -0.285466951780872 1.09948210132864e-08 NA NA NA hsa-miR-199a-5p EDARADD -0.364835768178638 0.0435119211101981 0.672320059330377 4.38689384348895e-10 MirTarget;miRanda -0.140685279126472 7.21507676355936e-08 NA NA NA hsa-miR-155-5p EDEM3 0.533437622040649 0.00248671179205372 -0.0110095358841784 0.911393886187156 miRNAWalker2_validate -0.13653768483638 1.32343247337901e-08 NA NA NA hsa-miR-155-5p EDN1 0.533437622040649 0.00248671179205372 -0.385963348422339 0.0462953413710172 miRNAWalker2_validate;miRTarBase -0.130175889465452 0.00645457185941329 NA NA NA hsa-miR-148a-5p EDNRA -1.00478606532747 1.38045244999229e-07 0.495256957598099 0.0143272281348787 mirMAP -0.112650852381172 0.013865349519947 NA NA NA hsa-miR-30a-5p EDNRA -1.79779915425811 1.93360169837799e-26 0.495256957598099 0.0143272281348787 mirMAP;miRNATAP -0.134305597058545 0.00685705126769144 26675258 miR 30a inhibits endothelin A receptor and chemoresistance in ovarian carcinoma; An inverse correlation was observed between the expression levels of miR-30a and ETAR in both EOC cell lines and tumor samples; miR-30a was found to specifically bind to the 3'UTR of ETAR mRNA indicating that ETAR is a direct target of miR-30a; Interestingly our findings highlight that blockade of ETAR regulatory axis is the mechanism underlying the tumor suppressor function of miR-30a in chemoresistant EOC cells drug resistance ovarian cancer hsa-miR-199a-5p EED -0.364835768178638 0.0435119211101981 0.38120834110107 1.38515880043599e-05 miRanda -0.104497871873272 7.14828898932978e-07 NA NA NA hsa-miR-155-5p EEF1A2 0.533437622040649 0.00248671179205372 -2.79873973354248 4.09282868370803e-09 miRNAWalker2_validate -0.724400715078079 7.071497128877e-10 NA NA NA hsa-miR-30a-5p EFNA3 -1.79779915425811 1.93360169837799e-26 -0.111220394827782 0.566844855883492 MirTarget;mirMAP;miRNATAP -0.197379638816703 3.05633349594278e-05 NA NA NA hsa-miR-30a-5p EFR3A -1.79779915425811 1.93360169837799e-26 0.239030286885304 0.0151621998432141 mirMAP;miRNATAP -0.145157184293674 1.03121326687616e-09 NA NA NA hsa-miR-155-5p EGFR 0.533437622040649 0.00248671179205372 0.421988255273135 0.0732089026211386 miRNAWalker2_validate;MirTarget -0.315457381088104 4.08354886790646e-08 NA NA NA hsa-miR-30a-5p EGFR -1.79779915425811 1.93360169837799e-26 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.306757641684714 8.20602294984162e-08 NA NA NA hsa-miR-193b-5p EHF 1.10486595354104 6.41489920661805e-11 -2.22099431697535 1.22243622908523e-14 MirTarget -0.162836733176271 0.0299576629258668 NA NA NA hsa-miR-199a-5p EHF -0.364835768178638 0.0435119211101981 -2.22099431697535 1.22243622908523e-14 miRanda -0.31327115975107 1.0080676002546e-05 NA NA NA hsa-miR-30a-5p EIF2AK2 -1.79779915425811 1.93360169837799e-26 1.4597056342819 1.19751017285558e-25 mirMAP -0.319346724045856 2.95267210414443e-20 NA NA NA hsa-miR-30a-5p EIF5A2 -1.79779915425811 1.93360169837799e-26 1.67988915186219 4.59161559532876e-24 mirMAP;miRNATAP -0.222980084459186 1.30082772986337e-07 NA NA NA hsa-miR-30a-5p ELAVL2 -1.79779915425811 1.93360169837799e-26 1.21088772565905 0.00623286669475479 miRNATAP -0.216383749633522 0.0472343045277362 NA NA NA hsa-miR-145-5p ELK4 -0.46917511594055 0.000685297625493134 0.356303519103072 0.00595480968167607 miRNATAP -0.140613335464447 0.000568096622182483 NA NA NA hsa-miR-30a-5p ELK4 -1.79779915425811 1.93360169837799e-26 0.356303519103072 0.00595480968167607 mirMAP -0.125665879574927 7.30859532422767e-05 NA NA NA hsa-miR-30a-5p ELL2 -1.79779915425811 1.93360169837799e-26 -0.544479865062607 0.000148886077608994 MirTarget;miRNATAP -0.17654683510896 4.81657288344553e-07 NA NA NA hsa-miR-193b-5p ELOVL6 1.10486595354104 6.41489920661805e-11 -1.15307345021188 1.18969900059071e-09 MirTarget -0.233604591629804 1.40702431890325e-06 NA NA NA hsa-miR-30a-5p ELOVL7 -1.79779915425811 1.93360169837799e-26 -0.00520943608326174 0.978829593647607 mirMAP -0.122353385129138 0.0109678070536784 NA NA NA hsa-miR-30a-5p EML1 -1.79779915425811 1.93360169837799e-26 -0.0666316945579748 0.749997007068752 MirTarget;miRNATAP -0.172344895079827 0.000748449893136339 NA NA NA hsa-miR-30a-5p EML5 -1.79779915425811 1.93360169837799e-26 0.579522863481988 0.00470715106516173 mirMAP -0.244023025623627 1.06758129633716e-06 NA NA NA hsa-miR-30a-5p EN2 -1.79779915425811 1.93360169837799e-26 2.84090307433433 9.20749316272825e-15 mirMAP -0.282125751115671 0.0022459317944136 NA NA NA hsa-miR-148a-5p ENAH -1.00478606532747 1.38045244999229e-07 0.963730515734473 6.22095258151065e-11 mirMAP -0.122415718493263 0.000294832611404024 NA NA NA hsa-miR-199a-5p ENKUR -0.364835768178638 0.0435119211101981 1.04357434210168 0.000610937006512365 MirTarget;miRanda -0.333979474009124 5.24818984255325e-06 NA NA NA hsa-miR-155-5p ENTPD3 0.533437622040649 0.00248671179205372 -0.652378757731169 0.0028282931903586 MirTarget -0.244583977654121 5.262414984899e-06 NA NA NA hsa-miR-199a-5p ENTPD5 -0.364835768178638 0.0435119211101981 -0.558394621407445 1.26974738282026e-05 miRanda -0.10283858220506 0.000910933915858337 NA NA NA hsa-miR-30a-5p EPB41L4B -1.79779915425811 1.93360169837799e-26 0.853504847641176 3.88329841562176e-06 MirTarget;mirMAP -0.145465353103558 0.00144566046248596 NA NA NA hsa-miR-155-5p ERBB4 0.533437622040649 0.00248671179205372 -3.92028579752201 3.08453741227061e-22 mirMAP -0.221902472981968 0.0333242704733329 NA NA NA hsa-miR-30a-5p ERCC6 -1.79779915425811 1.93360169837799e-26 0.0358732696458097 0.73987763438539 MirTarget -0.107191368807214 4.58902238622216e-05 NA NA NA hsa-miR-143-5p ERMP1 0.502923736905281 0.00432190530694735 -0.981624882236793 5.53736435430813e-09 MirTarget -0.129721821194908 0.00207975187695169 NA NA NA hsa-miR-199a-5p ERMP1 -0.364835768178638 0.0435119211101981 -0.981624882236793 5.53736435430813e-09 miRanda -0.15416822756062 0.000174303444563022 NA NA NA hsa-miR-145-5p ESCO2 -0.46917511594055 0.000685297625493134 1.39346366870109 1.59337676432774e-16 MirTarget -0.274250590264912 4.68483372315499e-07 NA NA NA hsa-miR-148a-5p ESM1 -1.00478606532747 1.38045244999229e-07 3.50937922750648 5.63090412921217e-43 MirTarget -0.200893940856117 0.00138051752899183 NA NA NA hsa-miR-155-5p ETNK2 0.533437622040649 0.00248671179205372 -0.877122596219739 0.00020211525430538 miRNATAP -0.236368742510504 4.98828856327914e-05 NA NA NA hsa-miR-30e-5p EXO1 -1.02114836019762 6.81961221797866e-17 2.04317908305931 3.01972917684699e-43 miRNAWalker2_validate -0.135492700530861 0.0157456873718235 NA NA NA hsa-miR-375 EXO1 -4.24070205340868 7.48368361454041e-28 2.04317908305931 3.01972917684699e-43 miRNAWalker2_validate -0.104251555267348 7.06723419877901e-10 NA NA NA hsa-miR-491-5p EXO1 -0.541680329196715 0.00135829217561865 2.04317908305931 3.01972917684699e-43 miRanda -0.124368024997443 0.00423444448038609 NA NA NA hsa-miR-199a-5p EXOSC3 -0.364835768178638 0.0435119211101981 0.592741460164418 8.5907812782527e-08 miRanda -0.111522286543651 3.29852014830792e-05 NA NA NA hsa-miR-148a-5p EXT1 -1.00478606532747 1.38045244999229e-07 1.31165097213395 5.51009542445664e-28 mirMAP -0.158697956691082 1.78994789736124e-08 NA NA NA hsa-miR-199a-5p EZH2 -0.364835768178638 0.0435119211101981 0.850744346547763 5.83288178737225e-10 miRNAWalker2_validate -0.106016470384045 0.00161357864546406 NA NA NA hsa-miR-199a-5p FA2H -0.364835768178638 0.0435119211101981 -1.58638256488813 1.64164561110645e-06 miRanda -0.269986802757436 0.000795015167179936 NA NA NA hsa-miR-155-5p FADD 0.533437622040649 0.00248671179205372 1.28423879344217 2.33501183649312e-11 miRTarBase -0.100053136539527 0.0387571521844899 NA NA NA hsa-miR-155-5p FADS1 0.533437622040649 0.00248671179205372 1.98101891403648 3.92095881008437e-23 miRNAWalker2_validate -0.121233949067131 0.0188664893712307 NA NA NA hsa-miR-30a-5p FAF2 -1.79779915425811 1.93360169837799e-26 0.265487077640334 0.000185092830400059 miRNAWalker2_validate;miRNATAP -0.100107633296132 5.90496721290557e-09 NA NA NA hsa-miR-145-5p FAM110C -0.46917511594055 0.000685297625493134 -0.528318792550886 0.0291511133805837 MirTarget -0.151871067189875 0.0472765658935345 NA NA NA hsa-miR-155-5p FAM114A1 0.533437622040649 0.00248671179205372 -0.492586386540411 0.000442140565481391 mirMAP -0.199614021962321 5.73129302824715e-09 NA NA NA hsa-miR-30a-5p FAM126A -1.79779915425811 1.93360169837799e-26 0.287046460093405 0.0341576349535391 mirMAP -0.192201482600394 4.67715351582246e-09 NA NA NA hsa-miR-145-5p FAM126B -0.46917511594055 0.000685297625493134 -0.290757082418161 0.00418402216989425 MirTarget -0.10111454856836 0.00156591856973346 NA NA NA hsa-miR-199a-5p FAM126B -0.364835768178638 0.0435119211101981 -0.290757082418161 0.00418402216989425 MirTarget;miRanda -0.102413187213886 2.65755631561225e-05 NA NA NA hsa-miR-155-5p FAM168A 0.533437622040649 0.00248671179205372 0.0934958867759419 0.572683709769992 MirTarget -0.178391128101639 1.1039400438085e-05 NA NA NA hsa-miR-30a-5p FAM199X -1.79779915425811 1.93360169837799e-26 0.119417158353467 0.211747823237715 mirMAP;miRNATAP -0.14369648133429 4.40302228004338e-10 NA NA NA hsa-miR-155-5p FAM20B 0.533437622040649 0.00248671179205372 0.129151535575367 0.113223784795699 mirMAP -0.106946407515325 6.89715266440514e-08 NA NA NA hsa-miR-30a-5p FAM43A -1.79779915425811 1.93360169837799e-26 -0.0147575932374533 0.933579698093977 MirTarget -0.183682044040717 2.06207738677523e-05 NA NA NA hsa-miR-30a-5p FAM69A -1.79779915425811 1.93360169837799e-26 1.03062922010903 3.71680707642698e-18 MirTarget -0.176888069947876 2.50180408755831e-09 NA NA NA hsa-miR-193b-5p FAM81A 1.10486595354104 6.41489920661805e-11 -0.716740371087697 0.00211886906868417 MirTarget -0.449047774213808 7.82181043575329e-15 NA NA NA hsa-miR-148a-5p FAM83A -1.00478606532747 1.38045244999229e-07 1.10663845961388 0.00142212364773144 mirMAP -0.43381477078535 2.44682255821325e-08 NA NA NA hsa-miR-30a-5p FAM83F -1.79779915425811 1.93360169837799e-26 0.376662924285444 0.024802991718435 MirTarget -0.232240489175479 1.15261194308106e-08 NA NA NA hsa-miR-30a-5p FAM91A1 -1.79779915425811 1.93360169837799e-26 0.663053981839322 1.49042516138027e-14 MirTarget -0.188518844346327 1.97357069849987e-19 NA NA NA hsa-miR-199a-5p FANCA -0.364835768178638 0.0435119211101981 1.56780530731436 1.90779384565269e-31 PITA;miRanda;miRNATAP -0.146893413065172 1.83845886811175e-05 NA NA NA hsa-miR-199a-5p FANCC -0.364835768178638 0.0435119211101981 0.945443432315619 2.22451455305285e-16 miRanda -0.168876002484643 2.1568730679526e-09 NA NA NA hsa-miR-199a-5p FANCD2 -0.364835768178638 0.0435119211101981 0.7857073225818 1.09034282768489e-09 miRanda -0.181261820274004 6.08164261016408e-09 NA NA NA hsa-miR-30a-5p FAP -1.79779915425811 1.93360169837799e-26 3.05741840345564 7.04689490017445e-28 miRNATAP -0.301990639938834 2.76732673182413e-05 NA NA NA hsa-miR-199a-5p FASLG -0.364835768178638 0.0435119211101981 0.394703525705912 0.21882393973136 miRanda -0.273318512204072 0.000400614015733864 NA NA NA hsa-miR-30a-5p FBXL20 -1.79779915425811 1.93360169837799e-26 0.284203369851014 0.000972118284259623 miRNATAP -0.104960557001593 5.55876201372482e-07 NA NA NA hsa-miR-30a-5p FBXO45 -1.79779915425811 1.93360169837799e-26 0.884818022690472 1.01039962806834e-14 miRNATAP -0.305897076063834 2.50079170802985e-29 NA NA NA hsa-miR-199a-5p FCRL5 -0.364835768178638 0.0435119211101981 1.16784566072069 0.00792251303766827 miRanda -0.270893024126377 0.0108971491573288 NA NA NA hsa-miR-30a-5p FEM1B -1.79779915425811 1.93360169837799e-26 -0.140060869269589 0.127548731896543 mirMAP -0.115709753707984 2.0260536867622e-07 NA NA NA hsa-miR-199a-5p FEN1 -0.364835768178638 0.0435119211101981 1.26437194886328 2.2916878826911e-30 miRanda -0.126915411253378 6.09200252037501e-06 NA NA NA hsa-miR-148a-5p FERMT1 -1.00478606532747 1.38045244999229e-07 1.27691889113843 1.13522737962633e-11 MirTarget;miRNATAP -0.149297300320588 0.000560363580675204 NA NA NA hsa-miR-155-5p FGD4 0.533437622040649 0.00248671179205372 -0.788355484815801 6.16316504348712e-11 mirMAP -0.111149086057456 0.000229885572113228 NA NA NA hsa-miR-30a-5p FGD6 -1.79779915425811 1.93360169837799e-26 1.26273983431251 3.77855336798699e-20 MirTarget;miRNATAP -0.213929542325159 5.38904106587588e-10 NA NA NA hsa-miR-155-5p FGF5 0.533437622040649 0.00248671179205372 2.03532963351149 1.96791908743617e-07 mirMAP -0.31284053064953 0.00133764239981059 NA NA NA hsa-miR-30a-5p FGF5 -1.79779915425811 1.93360169837799e-26 2.03532963351149 1.96791908743617e-07 mirMAP -0.236135286412433 0.0151060182102453 NA NA NA hsa-miR-155-5p FGF9 0.533437622040649 0.00248671179205372 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.198272021571944 0.0104915688734946 NA NA NA hsa-miR-155-5p FKBP14 0.533437622040649 0.00248671179205372 0.906402146585839 5.64546529938152e-10 mirMAP -0.218510484730825 1.48731933143976e-09 NA NA NA hsa-miR-148a-5p FKBP1A -1.00478606532747 1.38045244999229e-07 0.466755153409967 1.73987374052955e-07 miRNATAP -0.137462528375702 5.87060224218402e-12 NA NA NA hsa-miR-145-5p FLNB -0.46917511594055 0.000685297625493134 0.367505605988825 0.00532671883049422 MirTarget;miRNATAP -0.10341975246478 0.0130351183601752 NA NA NA hsa-miR-148a-5p FLRT2 -1.00478606532747 1.38045244999229e-07 1.16143384639535 8.18441065669102e-05 mirMAP -0.234678689236965 0.000449488559905835 NA NA NA hsa-miR-155-5p FLRT2 0.533437622040649 0.00248671179205372 1.16143384639535 8.18441065669102e-05 mirMAP -0.177396410941895 0.0154365461780924 NA NA NA hsa-miR-148a-5p FLRT3 -1.00478606532747 1.38045244999229e-07 0.112637977292001 0.807347674034959 MirTarget;miRNATAP -0.353410686256389 0.000682876137936717 NA NA NA hsa-miR-155-5p FLT1 0.533437622040649 0.00248671179205372 0.739056195142607 2.68348183147666e-07 miRNAWalker2_validate;mirMAP -0.110593121592625 0.00199016890826031 NA NA NA hsa-miR-30a-5p FLVCR1 -1.79779915425811 1.93360169837799e-26 0.561279817775879 0.000207333183606224 MirTarget -0.116971230792492 0.00168051885147496 NA NA NA hsa-miR-30a-5p FNDC3B -1.79779915425811 1.93360169837799e-26 1.26520937628685 1.48165674863151e-21 miRNAWalker2_validate;miRNATAP -0.106822468020373 0.00159867472023083 NA NA NA hsa-miR-30a-5p FNIP2 -1.79779915425811 1.93360169837799e-26 -0.382884787455003 0.0615479832469337 MirTarget;mirMAP -0.150837994125533 0.00266089642334375 NA NA NA hsa-miR-155-5p FOS 0.533437622040649 0.00248671179205372 -1.94423725327751 3.36208860239677e-15 MirTarget -0.151444454976104 0.0156657071431114 23693020 Also S100P treatment stimulated the enrichment of c-Fos an AP-1 family member at the miR-155 host gene promoter site colon cancer hsa-miR-30a-5p FOXD1 -1.79779915425811 1.93360169837799e-26 2.32257484335686 5.3960875998042e-22 miRNAWalker2_validate;MirTarget;miRNATAP -0.241100089415654 8.66320077717893e-05 NA NA NA hsa-miR-145-5p FOXD4 -0.46917511594055 0.000685297625493134 0.924785902208298 1.12741837567038e-05 MirTarget -0.146988779983845 0.0282300453401334 NA NA NA hsa-miR-199a-5p FOXD4 -0.364835768178638 0.0435119211101981 0.924785902208298 1.12741837567038e-05 miRanda -0.10331435046654 0.0439375778238364 NA NA NA hsa-miR-30a-5p FOXK1 -1.79779915425811 1.93360169837799e-26 0.634882251626572 1.0723525565945e-09 mirMAP -0.160208152159939 3.38668977975556e-10 NA NA NA hsa-miR-30a-5p FOXN2 -1.79779915425811 1.93360169837799e-26 0.579552631796807 3.7310623841678e-06 miRNATAP -0.227165601962179 5.96259406009466e-14 NA NA NA hsa-miR-155-5p FOXO3 0.533437622040649 0.00248671179205372 -0.326231432881512 0.00103053272543976 miRNAWalker2_validate;miRTarBase -0.117539461363734 1.41050306563265e-06 27596294;25480585;20371610;26398931;22027557;27107135 MiR-155 targets 3´UTR region of multiple components of the pro-oncogenic signaling cascades including FOXO3a tumor suppressor and RUNX2 transcription factor regulating metastatic potential in BC;The effect of miRNA155 on FOXO3a expression was examined by Western blotting; FOXO3a was found to be a possible target of miRNA155 as suggested by Targetscan website;MicroRNA 155 regulates cell survival growth and chemosensitivity by targeting FOXO3a in breast cancer; In this study we demonstrate the critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer; Further we identified FOXO3a as a direct target of miR-155; Sustained overexpression of miR-155 resulted in repression of FOXO3a protein without changing mRNA levels and knockdown of miR-155 increases FOXO3a; Finally inverse correlation between miR-155 and FOXO3a levels were observed in a panel of breast cancer cell lines and tumors; In conclusion our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer;In contrast downregulation of miR-155-5p increased sensitivity to bufalin and upregulated the expression of FOXO3A;Here we show that hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target FOXO3A;Our results further revealed that forkhead box O3a FoxO3a was a miR-155 target in the heart; And miR-155 directly repressed FoxO3a whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro ;;poor survival;;; breast cancer;lymphoma;breast cancer;breast cancer;lung cancer;breast cancer hsa-miR-193b-5p FOXP2 1.10486595354104 6.41489920661805e-11 -1.52806579399275 6.42738696047354e-05 MirTarget -0.579058562722144 1.71788932153366e-09 NA NA NA hsa-miR-30a-5p FRMD6 -1.79779915425811 1.93360169837799e-26 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.196498693311235 1.60604531490294e-10 NA NA NA hsa-miR-145-5p FSCN1 -0.46917511594055 0.000685297625493134 1.86676187103128 2.84553070003058e-29 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.129116505651833 0.0200852266788545 21351259;24642628;20160723;21258769;26173501;22457808;26238532;26010149;26544536;23404256;26309531;20818426 miR 145 miR 133a and miR 133b: Tumor suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma; The signal from a luciferase reporter assay was significantly decreased at 2 miR-145 target sites and 1 miR-133a/b site suggesting both miRNAs directly regulate FSCN1;MicroRNA 145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin 1;miR 145 and miR 133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer; We focused on fascin homologue 1 FSCN1 from the gene expression profile in miR-145 transfectant; BC specimens were subjected to immunohistochemistry of FSCN1 and in situ hybridisation of miR-145; The miR-133a as well as miR-145 had the target sequence of FSCN1 mRNA by the database search and both microRNAs repressed the mRNA and protein expression of FSCN1; The luciferase assay revealed that miR-145 and miR-133a were directly bound to FSCN1 mRNA; In situ hybridisation revealed that miR-145 expression was markedly repressed in the tumour lesion in which FSCN1 was strongly stained; Tumour suppressive miR-145 and miR-133a directly control oncogenic FSCN1 in BC;Restoration of miR 145 expression suppresses cell proliferation migration and invasion in prostate cancer by targeting FSCN1; A luciferase reporter assay showed a significantly decreased signal at two miR-145 target sites at the 3'UTR of FSCN1 suggesting that miR-145 directly regulates FSCN1;MicroRNA 145 and MicroRNA 133a Inhibited Proliferation Migration and Invasion While Promoted Apoptosis in Hepatocellular Carcinoma Cells Via Targeting FSCN1; Our study aimed to reveal the roles of microRNA miR-133a miR-145 and FSCN1 in HCC cells; Real-time RT-PCR and western blot were performed to determine the expression of miR-133a miR-145 and FSCN1; Luciferase reporter assay was used to determine whether FSCN1 was a target of miR-133a and miR-145; Effects of miR-133a miR-145 and FSCN1 on HCC cell proliferation apoptosis migration and invasion were then investigated; Moreover upregulation of FSCN1 and downregulation of miR-145 and miR-133a co-existed in HCC; Functional studies revealed that miR-145 and miR-133a negatively regulated the expression of FSCN1 in HCC cells via directly binding to the 3'-untranslational region of FSCN1 mRNA;The protein level of FSCN1 showed no significant linear correlation with miR-143 and miR-145 expression in ESCC cell lines with Western blotting analysis;MicroRNA 145 inhibits migration and invasion via inhibition of fascin 1 protein expression in non small cell lung cancer cells; However the detailed role of miR-145 as well as the association between miR-145 and FSCN1 in the regulation of migration and invasion in NSCLC cells has remained elusive; The present study revealed that miR-145 was downregulated and FSCN1 was upregulated in NSCLC tissues and cell lines; Further investigation showed that overexpression of miR-145 markedly inhibited the protein expression of FSCN1 while knockdown of miR-145 upregulated the protein but not mRNA levels of FSCN1 in the NSCLC cell line H129; Moreover a luciferase reporter assay indicated that FSCN1 is a direct target of miR-145 in NSCLC H129 cells; Furthermore overexpression of miR-145 markedly inhibited the migration and invasion of NSCLC cells similar to the effect of small interfering RNA-mediated FSCN1 inhibition in H129 cells; In addition the inhibitory effect of miR-145 overexpression on migration and invasion was reversed by FSCN1 upregulation in H129 cells; These findings suggested that miR-145 has an inhibitory effect on the migration and invasion in NSCLC cells at least in part through suppressing the protein expression of its target FSCN1;Reverse Correlation between MicroRNA 145 and FSCN1 Affecting Gastric Cancer Migration and Invasion; Additionally correlation analyses revealed strong inverse correlations between miR-145 and FSCN1 expression levels in infiltrative gastric cancer; Furthermore we demonstrated that miR-145 directly targets FSCN1 and suppresses cell migration and invasion in gastric cancer; Thus we concluded that miR-145 regulates cell migration and invasion in gastric cancer primarily by directly targeting FSCN1;Long non coding RNA urothelial cancer associated 1 promotes bladder cancer cell migration and invasion by way of the hsa miR 145 ZEB1/2 FSCN1 pathway;Surprisingly we discovered that miR-145 in melanoma in contrast to many other tumor types does not necessarily act via the target FSCN1 since the downregulation of FSCN1 did not inhibit cell proliferation or migration but on the contrary increased cell invasion in two out of the three melanoma cell lines examined;MicroRNA 145 inhibits migration and invasion by down regulating FSCN1 in lung cancer; Mechanistic studies showed that miR-145 mimics inhibited FSCN1 expression and miR-145 inhibitor enhanced it; Over-expression of FSCN1 reversed miR-145-regulated expression of EMT markers suggesting that FSCN1 mediated the inhibitory effects of miR-145; Our results revealed a novel mechanism that miR-145 inhibits lung cancer cells migration and invasion via FSCN1 downregulation;miR 145 dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness; Our data identify JAM-A and fascin as novel targets of miR-145 firmly establishing a role for miR-145 in modulating breast cancer cell motility ;metastasis;;;;;;cell migration;cell migration;;;motility esophageal cancer;colorectal cancer;bladder cancer;prostate cancer;liver cancer;esophageal cancer;lung squamous cell cancer;gastric cancer;bladder cancer;melanoma;lung cancer;breast cancer hsa-miR-30a-5p FSCN1 -1.79779915425811 1.93360169837799e-26 1.86676187103128 2.84553070003058e-29 miRNAWalker2_validate -0.453282506736016 1.49034851300667e-28 NA NA NA hsa-miR-217 FST -1.35391381055929 2.42394951427902e-09 2.37165182427043 2.66493146753049e-20 miRanda -0.134414760591989 0.00776503187074723 NA NA NA hsa-miR-224-3p FST 0.502645536188015 0.0081142387260641 2.37165182427043 2.66493146753049e-20 MirTarget -0.157640041088439 0.0106149375605241 NA NA NA hsa-miR-769-5p FST 0.0865819375213306 0.445395188017017 2.37165182427043 2.66493146753049e-20 MirTarget;miRNATAP -0.27897322962198 0.00699904197383682 NA NA NA hsa-miR-155-5p FSTL1 0.533437622040649 0.00248671179205372 0.473337980252804 0.0145905313351278 miRNAWalker2_validate -0.184649501741973 0.000108123021072387 NA NA NA hsa-miR-199a-5p FUBP1 -0.364835768178638 0.0435119211101981 0.345507876227636 0.000226686592354175 PITA;miRanda -0.113759421333666 4.09370479970721e-07 NA NA NA hsa-miR-30a-5p FUBP3 -1.79779915425811 1.93360169837799e-26 0.31613044161253 6.99545267025106e-05 miRNATAP -0.123648932341626 1.27474189058401e-10 NA NA NA hsa-miR-199a-5p FXYD3 -0.364835768178638 0.0435119211101981 0.352398217878831 0.0978384419293784 miRanda -0.169347187525727 0.000954160486342205 NA NA NA hsa-miR-155-5p FZD3 0.533437622040649 0.00248671179205372 -0.405919645349345 0.0378194076500925 mirMAP -0.113400775804032 0.0188350424150611 NA NA NA hsa-miR-155-5p GABARAPL1 0.533437622040649 0.00248671179205372 -0.362759760676311 0.00864855760776091 miRNAWalker2_validate -0.166252478759341 8.98828887075922e-07 NA NA NA hsa-miR-145-5p GABPB2 -0.46917511594055 0.000685297625493134 0.0259672379853684 0.799258230076052 mirMAP -0.100080132443999 0.00178678113085037 NA NA NA hsa-miR-199a-5p GALE -0.364835768178638 0.0435119211101981 -0.604911793139778 5.65306665233678e-06 miRanda -0.106513965553999 0.000987292354056324 NA NA NA hsa-miR-30a-5p GALNT2 -1.79779915425811 1.93360169837799e-26 0.945855107543536 5.54255211977815e-17 MirTarget;miRNATAP -0.137623419881243 1.18895717110419e-06 NA NA NA hsa-miR-199a-5p GALNT3 -0.364835768178638 0.0435119211101981 -0.125255189646738 0.46161564388986 miRanda -0.114931209071573 0.00502870451228787 NA NA NA hsa-miR-30a-5p GALNT3 -1.79779915425811 1.93360169837799e-26 -0.125255189646738 0.46161564388986 MirTarget;miRNATAP -0.151633676687001 0.000262934173709513 NA NA NA hsa-miR-193b-5p GAS7 1.10486595354104 6.41489920661805e-11 -1.96458072645545 1.31090712339025e-20 mirMAP -0.187280828264924 0.000740052238296532 NA NA NA hsa-miR-145-5p GATC -0.46917511594055 0.000685297625493134 0.205695035007674 0.0418206913056157 MirTarget -0.127244525304611 5.89213623444701e-05 NA NA NA hsa-miR-30a-5p GATC -1.79779915425811 1.93360169837799e-26 0.205695035007674 0.0418206913056157 miRNAWalker2_validate -0.13607208409663 2.6939951850865e-08 NA NA NA hsa-miR-199a-5p GBP1 -0.364835768178638 0.0435119211101981 1.0608023336195 2.30866759946699e-05 miRanda -0.214609372248459 0.000411545106733955 NA NA NA hsa-miR-143-5p GBP4 0.502923736905281 0.00432190530694735 0.245478359796556 0.369346344779762 mirMAP -0.240470316013867 0.000352795592570016 NA NA NA hsa-miR-199a-5p GCH1 -0.364835768178638 0.0435119211101981 -0.0816235235407592 0.534026526595776 miRanda -0.17744250115182 1.31503522324104e-08 NA NA NA hsa-miR-155-5p GCLC 0.533437622040649 0.00248671179205372 0.341632556495599 0.0669690001870483 miRNAWalker2_validate -0.190815912182725 3.07464436464869e-05 NA NA NA hsa-miR-155-5p GDF6 0.533437622040649 0.00248671179205372 1.88833328676442 3.03419672063328e-08 miRNATAP -0.272371911410391 0.00137467212123933 NA NA NA hsa-miR-30a-5p GFOD1 -1.79779915425811 1.93360169837799e-26 0.359616806520596 0.0172396823492257 mirMAP -0.254437250576773 2.51805773387907e-12 NA NA NA hsa-miR-155-5p GFPT1 0.533437622040649 0.00248671179205372 -0.237447404281525 0.0117588433034566 mirMAP -0.172880910446969 2.43626874964056e-14 NA NA NA hsa-miR-193b-5p GFRA1 1.10486595354104 6.41489920661805e-11 -2.76465617446264 1.46814325646303e-15 mirMAP -0.373322116382871 3.29648264066464e-05 NA NA NA hsa-miR-139-5p GINS1 -1.46099200329485 7.85040381494472e-22 1.53152882932905 1.11990719333606e-30 miRanda -0.262760750985812 5.59228350244071e-12 NA NA NA hsa-miR-486-5p GINS1 -1.70341092285685 6.64232609099498e-14 1.53152882932905 1.11990719333606e-30 miRanda -0.103259189092922 8.5610504701058e-05 NA NA NA hsa-miR-664a-3p GINS1 -0.256108763664991 0.0513188660751664 1.53152882932905 1.11990719333606e-30 mirMAP -0.169625179584269 0.000296903168023518 NA NA NA hsa-miR-369-3p GINS4 -1.2344419076994 2.66882944171146e-10 1.32061947741739 3.93513030921464e-17 mirMAP -0.215140109625606 8.86969563412763e-10 NA NA NA hsa-miR-381-3p GINS4 -2.21357103508055 2.33039447871705e-24 1.32061947741739 3.93513030921464e-17 MirTarget;mirMAP -0.223967551562716 1.39925527486419e-13 NA NA NA hsa-miR-495-3p GINS4 -1.47803501311999 6.88839745293927e-13 1.32061947741739 3.93513030921464e-17 mirMAP -0.227339090919243 5.47932598077314e-12 NA NA NA hsa-miR-664a-3p GINS4 -0.256108763664991 0.0513188660751664 1.32061947741739 3.93513030921464e-17 mirMAP -0.192500729843391 0.000345027377033132 NA NA NA hsa-miR-148a-5p GJA1 -1.00478606532747 1.38045244999229e-07 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.353029267539249 2.12549455639598e-11 NA NA NA hsa-miR-30a-5p GJA1 -1.79779915425811 1.93360169837799e-26 1.11294440604245 2.24989295389294e-06 MirTarget;miRNATAP -0.417068078527451 2.53328638997596e-13 NA NA NA hsa-miR-199a-5p GJB3 -0.364835768178638 0.0435119211101981 0.988618785211302 2.28716411642655e-06 miRanda -0.206703838073091 4.56516872353363e-05 NA NA NA hsa-miR-30a-5p GLDC -1.79779915425811 1.93360169837799e-26 0.582615757876661 0.155450382866374 MirTarget;miRNATAP -0.454650477438834 5.41392682031561e-06 NA NA NA hsa-miR-199a-5p GLE1 -0.364835768178638 0.0435119211101981 0.295907471633119 0.00033258565428371 miRanda -0.111620889338619 1.41257504796799e-08 NA NA NA hsa-miR-155-5p GLG1 0.533437622040649 0.00248671179205372 0.538531957055975 1.70312805087444e-11 miRNAWalker2_validate -0.120225519931594 1.22518031332179e-09 NA NA NA hsa-miR-30a-5p GLIPR1 -1.79779915425811 1.93360169837799e-26 0.888531209012557 6.06944326174294e-07 miRNAWalker2_validate -0.15771885415962 0.000339398109439154 NA NA NA hsa-miR-30a-5p GLRX3 -1.79779915425811 1.93360169837799e-26 0.415816067654936 3.85712847257061e-06 miRNAWalker2_validate -0.128218950619551 5.00373689036511e-09 NA NA NA hsa-miR-30a-5p GMFB -1.79779915425811 1.93360169837799e-26 0.429525829788851 2.3868578787342e-07 miRNAWalker2_validate;mirMAP -0.14075685929891 2.84878355499075e-12 NA NA NA hsa-miR-30a-5p GNA13 -1.79779915425811 1.93360169837799e-26 0.46687630467973 7.75928023602061e-08 miRNAWalker2_validate;mirMAP -0.134353353747926 2.23562307555447e-10 NA NA NA hsa-miR-193b-5p GNG7 1.10486595354104 6.41489920661805e-11 -1.96928829336781 3.56688408795345e-19 mirMAP -0.442850003718459 3.76350255190172e-15 NA NA NA hsa-miR-199a-5p GNPNAT1 -0.364835768178638 0.0435119211101981 0.532396471256211 9.32589432850996e-09 miRanda -0.139313641143615 4.07656104944155e-10 NA NA NA hsa-miR-155-5p GPAM 0.533437622040649 0.00248671179205372 -0.0768039048135334 0.437335824449164 miRNAWalker2_validate -0.10996749286824 5.28797691537555e-06 NA NA NA hsa-miR-145-5p GPD2 -0.46917511594055 0.000685297625493134 -0.425287391661858 0.000785775560179042 miRNATAP -0.108702738707308 0.0066334478434185 NA NA NA hsa-miR-199a-5p GPD2 -0.364835768178638 0.0435119211101981 -0.425287391661858 0.000785775560179042 miRanda;miRNATAP -0.157682549834402 2.04995104699144e-07 NA NA NA hsa-miR-155-5p GPM6B 0.533437622040649 0.00248671179205372 -0.534829876887766 0.0010377430184843 miRNAWalker2_validate;MirTarget -0.127531205226354 0.00155370099470811 NA NA NA hsa-miR-148a-5p GPR39 -1.00478606532747 1.38045244999229e-07 2.04525059798444 3.52207557852102e-11 mirMAP -0.229591701113725 0.00123221915614852 NA NA NA hsa-miR-199a-5p GPR39 -0.364835768178638 0.0435119211101981 2.04525059798444 3.52207557852102e-11 miRanda -0.357430603106909 2.15596974711502e-06 NA NA NA hsa-miR-199a-5p GPR78 -0.364835768178638 0.0435119211101981 -0.661899579261598 0.101544855036239 miRNAWalker2_validate;miRTarBase -0.197797159646041 0.0429143338201095 NA NA NA hsa-miR-155-5p GPRC5A 0.533437622040649 0.00248671179205372 -0.401903457170527 0.143289925874174 mirMAP -0.233419032845758 0.000552053706990856 NA NA NA hsa-miR-199a-5p GPRC5A -0.364835768178638 0.0435119211101981 -0.401903457170527 0.143289925874174 MirTarget;miRanda -0.210101977570476 0.00149119971755637 NA NA NA hsa-miR-199a-5p GPSM2 -0.364835768178638 0.0435119211101981 0.101017362743956 0.460039258189669 miRanda -0.150154200710341 4.39773948387841e-06 NA NA NA hsa-miR-30a-5p GRHL1 -1.79779915425811 1.93360169837799e-26 -1.38807174874569 1.2648436154052e-08 miRNATAP -0.162691296732256 0.00734355098688472 NA NA NA hsa-miR-199a-5p GRTP1 -0.364835768178638 0.0435119211101981 -0.21749430489446 0.175045151121306 miRanda -0.104268923757888 0.00697929363458373 NA NA NA hsa-miR-155-5p GSK3B 0.533437622040649 0.00248671179205372 0.343238217842623 0.000162620715851218 miRNAWalker2_validate;miRNATAP -0.129703405382586 5.34297193283262e-09 NA NA NA hsa-miR-193b-5p GSTM1 1.10486595354104 6.41489920661805e-11 -0.155675482383662 0.835685260422529 MirTarget -0.385230317664999 0.0428668002690251 NA NA NA hsa-miR-193b-5p GSTM2 1.10486595354104 6.41489920661805e-11 -0.883659598074116 0.0162994527295809 MirTarget -0.594746130319362 9.295275716796e-11 NA NA NA hsa-miR-193b-5p GSTM4 1.10486595354104 6.41489920661805e-11 -0.845335459447715 0.000101899996421056 MirTarget -0.509550559410327 1.09371068262356e-21 NA NA NA hsa-miR-30a-5p GTF2A1 -1.79779915425811 1.93360169837799e-26 -0.273897033354 0.184363609858156 mirMAP;miRNATAP -0.189110090856341 0.000176256876683474 NA NA NA hsa-miR-199a-5p GTF3C4 -0.364835768178638 0.0435119211101981 0.0970845788719892 0.401384686940646 miRanda -0.14335045718832 2.01083466790328e-07 NA NA NA hsa-miR-30a-5p GTF3C4 -1.79779915425811 1.93360169837799e-26 0.0970845788719892 0.401384686940646 miRNAWalker2_validate -0.101734132222012 0.000313306927051136 NA NA NA hsa-miR-199a-5p GZMB -0.364835768178638 0.0435119211101981 1.28890560876714 5.97224061687397e-06 miRanda -0.280590504846609 4.73439794455771e-05 NA NA NA hsa-miR-145-5p H2AFX -0.46917511594055 0.000685297625493134 0.762670386151986 1.34326137756829e-09 MirTarget;miRNATAP -0.120278387807516 0.00278995356027796 NA NA NA hsa-miR-148a-5p HAPLN1 -1.00478606532747 1.38045244999229e-07 3.42103169010115 7.29122247320492e-35 mirMAP -0.192234938153844 0.00425130507609707 NA NA NA hsa-miR-199a-5p HELLS -0.364835768178638 0.0435119211101981 1.18707380165631 1.58272174990733e-16 miRanda -0.14999829483776 2.50396348820655e-05 NA NA NA hsa-miR-199a-5p HERC6 -0.364835768178638 0.0435119211101981 0.118527919444685 0.613142231699712 miRanda -0.235072787448678 2.89258660116946e-05 NA NA NA hsa-miR-155-5p HIF1A 0.533437622040649 0.00248671179205372 0.669817670907295 4.04045371604487e-06 MirTarget -0.166095452335493 3.6975721543014e-06 NA NA NA hsa-miR-155-5p HIVEP2 0.533437622040649 0.00248671179205372 -0.198476594184105 0.087480734274365 miRNAWalker2_validate;miRTarBase;miRNATAP -0.103405685506174 0.0002891458908906 NA NA NA hsa-miR-155-5p HK2 0.533437622040649 0.00248671179205372 0.21351878182556 0.209767407581829 miRNAWalker2_validate -0.232714496178968 2.0061360297135e-08 27315591;22354042 Inhibition of microRNA 155 sensitizes lung cancer cells to irradiation via suppression of HK2 modulated glucose metabolism;We further show that miR-155 acts to upregulate hexokinase 2 hk2 through two distinct mechanisms ; lung cancer;breast cancer hsa-miR-199a-5p HK2 -0.364835768178638 0.0435119211101981 0.21351878182556 0.209767407581829 miRanda -0.134646220239292 0.00101117169380765 26054020 MiR 199a 5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer; The up-regulation of hypoxia-inducible factor-1α under hypoxic conditions suppresses the expression of miR-199a-5p and promotes glycolysis whereas reintroduction of miR-199a-5p interferes with the expression of HK2 abrogating hypoxia-enhanced glycolysis liver cancer hsa-miR-148a-5p HMGA2 -1.00478606532747 1.38045244999229e-07 4.45669314139083 6.73354275393639e-30 mirMAP -0.523038517814871 1.85520060076771e-08 NA NA NA hsa-miR-199a-5p HMGA2 -0.364835768178638 0.0435119211101981 4.45669314139083 6.73354275393639e-30 miRanda -0.275403367704305 0.00610524579591463 NA NA NA hsa-miR-30a-5p HMGA2 -1.79779915425811 1.93360169837799e-26 4.45669314139083 6.73354275393639e-30 mirMAP -0.615108101185708 1.0013099700026e-09 NA NA NA hsa-miR-30a-5p HMGB3 -1.79779915425811 1.93360169837799e-26 1.28599879192957 2.29315074034646e-23 miRNATAP -0.141120603497113 1.82487699713014e-05 NA NA NA hsa-miR-199a-5p HOOK1 -0.364835768178638 0.0435119211101981 -0.6142319404412 0.00199356870490426 miRanda -0.190465437697115 6.96623269460595e-05 NA NA NA hsa-miR-30a-5p HOXA11 -1.79779915425811 1.93360169837799e-26 4.47607269595608 1.07429423251549e-34 miRNATAP -0.434797675935202 4.90425391816059e-06 NA NA NA hsa-miR-199a-5p HPS5 -0.364835768178638 0.0435119211101981 -0.10479999933864 0.277140803537686 miRanda -0.109271644506729 2.06107017895605e-06 NA NA NA hsa-miR-143-5p HS3ST1 0.502923736905281 0.00432190530694735 -1.82309392854182 2.82810094125236e-16 mirMAP -0.219262128757963 0.000104653186722546 NA NA NA hsa-miR-155-5p HSD17B12 0.533437622040649 0.00248671179205372 -0.354391575613972 0.000403628833148529 miRNAWalker2_validate -0.129156566991665 1.39683712622953e-07 NA NA NA hsa-miR-30a-5p HSPA5 -1.79779915425811 1.93360169837799e-26 0.472862006960789 2.11549330801204e-08 miRNATAP -0.106639022933489 2.66762549439822e-07 NA NA NA hsa-miR-155-5p HTRA1 0.533437622040649 0.00248671179205372 1.39038826622041 4.31761109410639e-12 miRNAWalker2_validate -0.181419286331425 0.000322771453972801 NA NA NA hsa-miR-30a-5p HTRA3 -1.79779915425811 1.93360169837799e-26 2.16808350336304 1.68962464682378e-16 miRNATAP -0.160691723545618 0.0158250637662564 NA NA NA hsa-miR-30a-5p ICOS -1.79779915425811 1.93360169837799e-26 1.63752708812785 4.8782212316208e-11 miRNATAP -0.183068102035144 0.00326994103299094 NA NA NA hsa-miR-30a-5p IDE -1.79779915425811 1.93360169837799e-26 -0.643119150079188 5.64113051859563e-06 miRNATAP -0.101065464784184 0.00388191437362973 NA NA NA hsa-miR-148a-5p IFFO2 -1.00478606532747 1.38045244999229e-07 -0.595502330200621 0.00425558269119494 mirMAP -0.192244681262211 4.25668990802636e-05 NA NA NA hsa-miR-30a-5p IFFO2 -1.79779915425811 1.93360169837799e-26 -0.595502330200621 0.00425558269119494 MirTarget -0.173056154306481 0.00071173629103893 NA NA NA hsa-miR-326 IFI6 -0.425943992128769 0.0415010315530797 3.06780363855733 9.54376344173081e-25 miRanda -0.156478679520318 0.0171852257237468 NA NA NA hsa-miR-375 IFI6 -4.24070205340868 7.48368361454041e-28 3.06780363855733 9.54376344173081e-25 miRNAWalker2_validate -0.210587678805898 1.31814644781852e-10 NA NA NA hsa-miR-375 IFIT1 -4.24070205340868 7.48368361454041e-28 1.64393831403887 1.11321423598777e-07 miRNAWalker2_validate -0.140675866108067 2.19726132109524e-05 NA NA NA hsa-miR-199a-5p IFIT2 -0.364835768178638 0.0435119211101981 1.54706205720806 4.13856867177248e-09 miRanda -0.233507712760273 0.000280509173781086 NA NA NA hsa-miR-155-5p IGDCC4 0.533437622040649 0.00248671179205372 -0.570091415281591 0.0264864139997728 MirTarget -0.154955894342205 0.0146582030244452 NA NA NA hsa-miR-155-5p IGF1R 0.533437622040649 0.00248671179205372 0.658946603715235 3.61776569897156e-07 mirMAP -0.224562941255931 1.20598024492178e-12 NA NA NA hsa-miR-30a-5p IGF1R -1.79779915425811 1.93360169837799e-26 0.658946603715235 3.61776569897156e-07 miRNAWalker2_validate;mirMAP;miRNATAP -0.183683218204462 6.72293627860893e-09 26025408 MiR 30a suppresses non small cell lung cancer progression through AKT signaling pathway by targeting IGF1R progression lung squamous cell cancer hsa-miR-155-5p IGF2R 0.533437622040649 0.00248671179205372 0.359630774721815 0.00223788573094562 miRNAWalker2_validate -0.120547252961916 3.08658450557881e-05 NA NA NA hsa-miR-30a-5p IKBIP -1.79779915425811 1.93360169837799e-26 1.21231565108642 3.04782275743389e-27 miRNAWalker2_validate;MirTarget -0.11031610879394 0.000132882162241335 NA NA NA hsa-miR-199a-5p IKBKAP -0.364835768178638 0.0435119211101981 0.445483157251038 8.38547300973328e-07 miRanda -0.103821397738125 1.94241205190146e-06 NA NA NA hsa-miR-143-5p IKZF2 0.502923736905281 0.00432190530694735 -2.03941807082466 1.03633437768469e-19 MirTarget;miRNATAP -0.193579425610019 0.000752400905177187 NA NA NA hsa-miR-199a-5p IL12RB2 -0.364835768178638 0.0435119211101981 1.31444496055573 7.43774977052584e-05 miRanda -0.416706670617934 1.76590061297805e-07 NA NA NA hsa-miR-155-5p IL17RD 0.533437622040649 0.00248671179205372 -1.16268353655654 2.50865171046093e-11 mirMAP -0.101837190006511 0.020251362637293 NA NA NA hsa-miR-30a-5p IL1A -1.79779915425811 1.93360169837799e-26 2.00781280937654 2.39057383153864e-08 MirTarget -0.539003354188258 9.90088532260576e-10 NA NA NA hsa-miR-199a-5p IL1RAP -0.364835768178638 0.0435119211101981 0.493350312117789 0.00341295743785046 miRanda -0.105578749738656 0.00958008218908708 NA NA NA hsa-miR-145-5p IL2RB -0.46917511594055 0.000685297625493134 0.46694737201397 0.0313292505714046 mirMAP -0.263756357761351 0.000109679838824784 NA NA NA hsa-miR-199a-5p IL4R -0.364835768178638 0.0435119211101981 0.235292415840093 0.0918561844265687 miRNATAP -0.10472059568867 0.00183087225916112 NA NA NA hsa-miR-155-5p IL6R 0.533437622040649 0.00248671179205372 -0.0486500175487801 0.809389037083792 MirTarget -0.15237980071983 0.00213783871461113 NA NA NA hsa-miR-30a-5p IL6R -1.79779915425811 1.93360169837799e-26 -0.0486500175487801 0.809389037083792 mirMAP -0.240383543244608 9.339773290795e-07 NA NA NA hsa-miR-155-5p IL6ST 0.533437622040649 0.00248671179205372 -1.51869334916695 1.31557122936242e-06 mirMAP -0.182973619391477 0.0194437648393228 NA NA NA hsa-miR-30a-5p INHBA -1.79779915425811 1.93360169837799e-26 4.26601463971428 2.67387095552321e-28 mirMAP -0.689237667848418 2.41228115290519e-12 NA NA NA hsa-miR-155-5p INTS6 0.533437622040649 0.00248671179205372 -0.155938158878044 0.0900921197842394 miRNAWalker2_validate;MirTarget -0.130039516360382 5.90663280499952e-09 NA NA NA hsa-miR-30a-5p INTS6 -1.79779915425811 1.93360169837799e-26 -0.155938158878044 0.0900921197842394 miRNAWalker2_validate -0.12699963040086 1.11615988038104e-08 NA NA NA hsa-miR-145-5p IPMK -0.46917511594055 0.000685297625493134 -0.387882765089362 0.121253207513006 miRNATAP -0.160786792626194 0.0419058956173374 NA NA NA hsa-miR-30a-5p IPMK -1.79779915425811 1.93360169837799e-26 -0.387882765089362 0.121253207513006 mirMAP;miRNATAP -0.241424952454816 7.88777953873887e-05 NA NA NA hsa-miR-199a-5p IQCH -0.364835768178638 0.0435119211101981 0.439122746788489 0.00366707889968615 miRanda -0.112273161164134 0.00209503447766208 NA NA NA hsa-miR-145-5p IRF4 -0.46917511594055 0.000685297625493134 0.267391871401678 0.308764070889687 mirMAP -0.167272544223086 0.0436044373510278 NA NA NA hsa-miR-199a-5p IRF9 -0.364835768178638 0.0435119211101981 0.935327841862363 2.83850764640282e-13 miRanda -0.104123103816093 0.000969227209352264 NA NA NA hsa-miR-30a-5p IRS1 -1.79779915425811 1.93360169837799e-26 0.368700428225394 0.0670438573223234 MirTarget;miRNATAP -0.185934232685065 0.000158575656242886 NA NA NA hsa-miR-199a-5p ITGA2 -0.364835768178638 0.0435119211101981 0.346311971701161 0.0557914662203759 miRanda -0.138525415191616 0.00149655053123041 NA NA NA hsa-miR-30a-5p ITGA2 -1.79779915425811 1.93360169837799e-26 0.346311971701161 0.0557914662203759 miRNAWalker2_validate;mirMAP -0.126199425147886 0.00447937148121829 NA NA NA hsa-miR-199a-5p ITGA3 -0.364835768178638 0.0435119211101981 1.42521574039313 1.3762201197134e-11 MirTarget;PITA;miRanda;miRNATAP -0.202715698601488 8.8151098322191e-05 NA NA NA hsa-miR-30a-5p ITGA5 -1.79779915425811 1.93360169837799e-26 2.26391898266591 1.00857076132898e-26 miRNATAP -0.353113981398324 5.08086526872968e-11 NA NA NA hsa-miR-30a-5p ITGA6 -1.79779915425811 1.93360169837799e-26 1.64611930993808 4.50484535118728e-16 miRNAWalker2_validate -0.396304205077658 1.89908587847505e-15 NA NA NA hsa-miR-30a-5p ITGB4 -1.79779915425811 1.93360169837799e-26 1.23080110172502 2.63931625007492e-12 miRNAWalker2_validate -0.281754609360929 8.20641992782776e-11 NA NA NA hsa-miR-155-5p ITGB5 0.533437622040649 0.00248671179205372 0.447092111973153 0.000319722883344347 miRNAWalker2_validate -0.220467292668732 2.32926315568984e-13 NA NA NA hsa-miR-30a-5p ITPK1 -1.79779915425811 1.93360169837799e-26 0.530251725586337 3.49683022358158e-08 miRNATAP -0.106658807292711 6.72489479153116e-06 NA NA NA hsa-miR-30a-5p ITPRIP -1.79779915425811 1.93360169837799e-26 -0.207427285466617 0.0850815654403701 miRNAWalker2_validate -0.138468239856505 2.28597714047648e-06 NA NA NA hsa-miR-30a-5p JARID2 -1.79779915425811 1.93360169837799e-26 0.387036678358002 0.000316089995334715 MirTarget;miRNATAP -0.21348004354458 9.13023070261416e-17 NA NA NA hsa-miR-155-5p JUP 0.533437622040649 0.00248671179205372 0.153261070835855 0.336197991503981 miRNAWalker2_validate -0.121115894382752 0.00200974189567554 NA NA NA hsa-miR-30a-5p JUP -1.79779915425811 1.93360169837799e-26 0.153261070835855 0.336197991503981 miRNAWalker2_validate -0.321709503903457 1.90859758181233e-17 NA NA NA hsa-miR-155-5p KCNA1 0.533437622040649 0.00248671179205372 -1.73304747134519 6.25625972001525e-07 mirMAP;miRNATAP -0.233523261648766 0.00708743326790435 NA NA NA hsa-miR-193b-5p KCNC3 1.10486595354104 6.41489920661805e-11 0.515422773366037 0.0191712293107926 mirMAP -0.385715529549416 1.75762310697795e-12 NA NA NA hsa-miR-193b-5p KCNJ10 1.10486595354104 6.41489920661805e-11 1.18444124945881 0.000460764227584701 MirTarget -0.428094113750591 5.25511530750441e-07 NA NA NA hsa-miR-143-5p KCNJ2 0.502923736905281 0.00432190530694735 -0.900593567261534 3.64709266470965e-06 MirTarget;miRNATAP -0.101412928951776 0.0365885652642798 NA NA NA hsa-miR-193b-5p KCNT1 1.10486595354104 6.41489920661805e-11 -1.89770419513559 1.28675450537835e-07 MirTarget -0.403326772403031 1.06993791391723e-05 NA NA NA hsa-miR-30a-5p KCTD5 -1.79779915425811 1.93360169837799e-26 0.328142115165583 1.63570374915225e-05 miRNATAP -0.148648132491436 3.34206307572737e-16 NA NA NA hsa-miR-155-5p KDELC1 0.533437622040649 0.00248671179205372 1.40644639884243 1.67143880018051e-24 miRNAWalker2_validate -0.132775988489719 0.000181805461790562 NA NA NA hsa-miR-155-5p KDELC2 0.533437622040649 0.00248671179205372 0.0625637386513089 0.566603034672753 miRNAWalker2_validate -0.111654814806622 2.92844768797654e-05 NA NA NA hsa-miR-199a-5p KDM1B -0.364835768178638 0.0435119211101981 0.297453208974999 0.00612250592682983 miRanda;miRNATAP -0.100452724113499 0.000118204742360291 NA NA NA hsa-miR-199a-5p KDM3B -0.364835768178638 0.0435119211101981 -0.335421736655751 0.000559698584094172 miRanda -0.110350207465187 2.23610568242476e-06 NA NA NA hsa-miR-155-5p KDM5B 0.533437622040649 0.00248671179205372 0.40513168541997 0.000642289516700658 MirTarget -0.217664340233275 3.13065448608416e-14 NA NA NA hsa-miR-30a-5p KDM6B -1.79779915425811 1.93360169837799e-26 0.048758961083486 0.648999489407999 miRNATAP -0.12878898750886 7.1351941011263e-07 NA NA NA hsa-miR-193b-5p KIAA0232 1.10486595354104 6.41489920661805e-11 -0.973003739028418 2.82100487046304e-25 MirTarget -0.105874033717886 1.86073180162774e-05 NA NA NA hsa-miR-155-5p KIAA1462 0.533437622040649 0.00248671179205372 0.319959803518719 0.0924791220597341 MirTarget -0.124037863561699 0.00818648963401092 NA NA NA hsa-miR-199a-5p KIAA1522 -0.364835768178638 0.0435119211101981 -0.0258984872542909 0.81410742913346 mirMAP -0.123438465519878 2.69068669923029e-06 NA NA NA hsa-miR-193b-5p KIAA1958 1.10486595354104 6.41489920661805e-11 -0.395697378643145 0.0313146981475248 mirMAP -0.104453353345074 0.0250768528694797 NA NA NA hsa-miR-199a-5p KIF11 -0.364835768178638 0.0435119211101981 1.21675672283213 1.15181214077167e-21 miRanda -0.183703684004233 5.89704866429936e-09 NA NA NA hsa-miR-199b-5p KIF11 -1.08432682485992 7.68241801134089e-10 1.21675672283213 1.15181214077167e-21 miRanda -0.20191285931041 2.03980351361124e-10 NA NA NA hsa-miR-30a-5p KIF11 -1.79779915425811 1.93360169837799e-26 1.21675672283213 1.15181214077167e-21 miRNAWalker2_validate;MirTarget -0.189232539009041 3.67283993811584e-09 NA NA NA hsa-miR-30c-5p KIF11 0.021222006155897 0.886366656528128 1.21675672283213 1.15181214077167e-21 MirTarget -0.100384218228747 0.010181260520301 NA NA NA hsa-miR-338-3p KIF11 -0.948755228846395 8.99167125682392e-08 1.21675672283213 1.15181214077167e-21 miRanda -0.143876407628316 6.84543426511633e-06 NA NA NA hsa-miR-381-3p KIF11 -2.21357103508055 2.33039447871705e-24 1.21675672283213 1.15181214077167e-21 MirTarget -0.165987090315704 2.5993919563773e-11 NA NA NA hsa-miR-655-3p KIF11 -1.15004187025356 3.60771552708797e-07 1.21675672283213 1.15181214077167e-21 MirTarget -0.164917693587524 1.61860300024656e-10 NA NA NA hsa-miR-664a-3p KIF11 -0.256108763664991 0.0513188660751664 1.21675672283213 1.15181214077167e-21 MirTarget -0.241438514204109 3.14572808523129e-08 NA NA NA hsa-miR-199a-5p KIF13B -0.364835768178638 0.0435119211101981 -1.28830277220719 4.3989145152177e-16 mirMAP -0.13046968688592 0.000903416880456577 NA NA NA hsa-miR-30a-5p KIF16B -1.79779915425811 1.93360169837799e-26 0.192918966278983 0.129137419222786 miRNATAP -0.2146755421182 2.00783537816368e-12 NA NA NA hsa-miR-125a-5p KIF18B 0.215366061934933 0.119550904549401 2.03353024564111 7.00427214538341e-44 miRanda -0.102236693449464 0.04331910837544 NA NA NA hsa-miR-491-5p KIF18B -0.541680329196715 0.00135829217561865 2.03353024564111 7.00427214538341e-44 miRanda -0.131861202433958 0.00215529373737383 NA NA NA hsa-miR-199a-5p KIF24 -0.364835768178638 0.0435119211101981 0.675500878207765 1.10894754384074e-05 miRanda -0.230112536287563 3.9667108348058e-10 NA NA NA hsa-miR-101-3p KIF2C -1.91263766544878 1.50270129259053e-39 2.08541313861933 5.14503243032315e-49 miRNAWalker2_validate -0.275725761682122 1.08547322680412e-10 NA NA NA hsa-miR-148a-5p KIFC3 -1.00478606532747 1.38045244999229e-07 0.702356838674134 7.09759370636476e-06 MirTarget -0.299664806394042 3.55150210389075e-18 NA NA NA hsa-miR-30a-5p KLF13 -1.79779915425811 1.93360169837799e-26 0.389764700537353 0.0014302576547257 miRNATAP -0.175993047347154 2.9340890471139e-09 NA NA NA hsa-miR-145-5p KLF4 -0.46917511594055 0.000685297625493134 -1.22082017416632 1.95130121335358e-09 miRNAWalker2_validate;miRTarBase -0.165832591626542 0.0109348133655491 NA NA NA hsa-miR-145-5p KLF5 -0.46917511594055 0.000685297625493134 -0.622763668401094 0.000181301278621816 miRTarBase;miRNATAP -0.153496215771963 0.00356511095647597 NA NA NA hsa-miR-199a-5p KLF7 -0.364835768178638 0.0435119211101981 1.38506541123094 2.19190759421332e-12 mirMAP -0.123148941317673 0.0113776555499348 NA NA NA hsa-miR-155-5p KPNA1 0.533437622040649 0.00248671179205372 0.248043026748785 0.00172939418615738 miRNATAP -0.124245706395389 9.63799500565542e-11 NA NA NA hsa-miR-30a-5p KPNA1 -1.79779915425811 1.93360169837799e-26 0.248043026748785 0.00172939418615738 miRNAWalker2_validate -0.124188780116677 7.64306454105715e-11 NA NA NA hsa-miR-199a-5p KPNA2 -0.364835768178638 0.0435119211101981 1.31594707451841 2.1663033946508e-36 miRanda -0.15385024716082 8.47286172012997e-09 NA NA NA hsa-miR-155-5p KPNA4 0.533437622040649 0.00248671179205372 0.158312516846914 0.0342712427871711 miRNATAP -0.121047021609083 2.00068664349746e-11 NA NA NA hsa-miR-155-5p KRAS 0.533437622040649 0.00248671179205372 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRNATAP -0.106787251340147 1.12687232356945e-05 NA NA NA hsa-miR-30a-5p KRAS -1.79779915425811 1.93360169837799e-26 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.109380981252874 6.01372957790632e-06 NA NA NA hsa-miR-199a-5p KRT37 -0.364835768178638 0.0435119211101981 1.33321266777031 0.00150557797359698 miRanda;miRNATAP -0.261539433448799 0.010172518301006 NA NA NA hsa-miR-30a-5p KRT6B -1.79779915425811 1.93360169837799e-26 0.886467681440188 0.0167915422038767 miRNAWalker2_validate -0.710055011734481 1.1695207376459e-15 NA NA NA hsa-miR-155-5p KRT80 0.533437622040649 0.00248671179205372 -1.32693249929659 2.59402896019849e-06 miRNAWalker2_validate -0.177674197386974 0.0115181197432816 NA NA NA hsa-miR-155-5p KSR2 0.533437622040649 0.00248671179205372 -0.534254771508894 0.0888938131734096 mirMAP -0.310706720879862 5.65542519554073e-05 NA NA NA hsa-miR-193b-5p KSR2 1.10486595354104 6.41489920661805e-11 -0.534254771508894 0.0888938131734096 mirMAP -0.586635814919543 4.38209409806508e-14 NA NA NA hsa-miR-155-5p LCA5 0.533437622040649 0.00248671179205372 -0.913210817372985 3.07138584036776e-06 MirTarget -0.144778973925397 0.0029336533222607 NA NA NA hsa-miR-155-5p LCLAT1 0.533437622040649 0.00248671179205372 0.627475126102839 1.31265661319488e-11 miRNAWalker2_validate -0.13895243166189 1.42490651841912e-09 NA NA NA hsa-miR-30a-5p LCLAT1 -1.79779915425811 1.93360169837799e-26 0.627475126102839 1.31265661319488e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.136186167159258 2.48312949934256e-09 NA NA NA hsa-miR-145-5p LCOR -0.46917511594055 0.000685297625493134 -0.45662089077371 0.0431097259602448 miRNATAP -0.157778542999869 0.0269044202515536 NA NA NA hsa-miR-155-5p LCOR 0.533437622040649 0.00248671179205372 -0.45662089077371 0.0431097259602448 miRNATAP -0.141116391391079 0.0113610105582695 NA NA NA hsa-miR-199a-5p LCOR -0.364835768178638 0.0435119211101981 -0.45662089077371 0.0431097259602448 miRNATAP -0.249081608941798 4.20155374133341e-06 NA NA NA hsa-miR-30a-5p LCOR -1.79779915425811 1.93360169837799e-26 -0.45662089077371 0.0431097259602448 mirMAP;miRNATAP -0.115852383950018 0.0368087239491404 NA NA NA hsa-miR-30a-5p LDLR -1.79779915425811 1.93360169837799e-26 -0.103028631831687 0.494550619299086 miRNAWalker2_validate -0.164381129452947 7.51952628412236e-06 NA NA NA hsa-miR-155-5p LEPROT 0.533437622040649 0.00248671179205372 -0.312403972869239 0.0995287598709371 mirMAP -0.176489850704425 0.000153055456943579 NA NA NA hsa-miR-30a-5p LHFPL2 -1.79779915425811 1.93360169837799e-26 0.895976184348805 4.06627147704909e-11 MirTarget;mirMAP -0.113986943417004 0.000756830992659157 NA NA NA hsa-miR-30a-5p LHX1 -1.79779915425811 1.93360169837799e-26 3.75241498960514 4.81623648614382e-15 MirTarget -0.772979774785788 7.93122996619281e-11 NA NA NA hsa-miR-30a-5p LHX9 -1.79779915425811 1.93360169837799e-26 2.19484609879797 1.06320816651888e-07 mirMAP -0.57662333286767 1.27020970716041e-08 NA NA NA hsa-miR-199a-5p LILRA5 -0.364835768178638 0.0435119211101981 0.954532138857898 7.8027992508496e-05 miRanda -0.125178636342322 0.0330511095451544 NA NA NA hsa-miR-30a-5p LIMS1 -1.79779915425811 1.93360169837799e-26 0.196981967170581 0.256339758558295 MirTarget -0.188428095237781 8.26629435912502e-06 NA NA NA hsa-miR-199a-5p LIPH -0.364835768178638 0.0435119211101981 -1.8041001037855 2.02843912939924e-08 miRanda -0.316647720251265 5.2920857424379e-05 NA NA NA hsa-miR-199a-5p LMNB1 -0.364835768178638 0.0435119211101981 0.870736037380067 3.81160197841351e-10 miRanda -0.195239910926287 6.72669132842212e-09 NA NA NA hsa-miR-30a-5p LMNB2 -1.79779915425811 1.93360169837799e-26 1.0567195440345 7.01197089583625e-23 miRNAWalker2_validate -0.193553824987405 6.10406935806774e-13 NA NA NA hsa-miR-155-5p LNX2 0.533437622040649 0.00248671179205372 -0.282988148163895 0.0085232244592434 miRNAWalker2_validate -0.114690442974463 1.38690499711196e-05 NA NA NA hsa-miR-155-5p LONP2 0.533437622040649 0.00248671179205372 -0.326818803345971 0.000723460570033028 miRNAWalker2_validate -0.171990429195432 1.80106674987454e-13 NA NA NA hsa-miR-155-5p LONRF2 0.533437622040649 0.00248671179205372 -3.20521256893066 4.35525307822128e-14 mirMAP -0.331331470240117 0.0020300361957564 NA NA NA hsa-miR-30a-5p LOX -1.79779915425811 1.93360169837799e-26 1.35314081026531 4.05468571218723e-08 miRNATAP -0.284770704313371 2.86608298388046e-06 NA NA NA hsa-miR-30a-5p LPCAT2 -1.79779915425811 1.93360169837799e-26 0.436491204723454 0.00589113211591419 MirTarget -0.148569703102692 0.000129106971963893 NA NA NA hsa-miR-155-5p LPP 0.533437622040649 0.00248671179205372 0.215391621349877 0.170893929328744 mirMAP;miRNATAP -0.225588020558745 3.70901674528884e-09 NA NA NA hsa-miR-30a-5p LPP -1.79779915425811 1.93360169837799e-26 0.215391621349877 0.170893929328744 miRNATAP -0.197535982185183 2.30559189210728e-07 NA NA NA hsa-miR-199a-5p LRBA -0.364835768178638 0.0435119211101981 -0.718096817151609 3.80412144940738e-10 miRanda -0.121466831186475 1.38441276743894e-05 NA NA NA hsa-miR-155-5p LRP1B 0.533437622040649 0.00248671179205372 -2.49891168594474 3.39138670699814e-10 MirTarget;miRNATAP -0.336765193143098 0.000732935248159827 NA NA NA hsa-miR-199a-5p LRP8 -0.364835768178638 0.0435119211101981 1.36470531054614 1.53754536235093e-15 miRanda -0.108936375470138 0.0103508055869461 NA NA NA hsa-miR-199a-5p LRRC1 -0.364835768178638 0.0435119211101981 -0.0591569530685501 0.598844525762497 miRanda -0.112256515561862 3.04134457904893e-05 NA NA NA hsa-miR-30a-5p LRRC15 -1.79779915425811 1.93360169837799e-26 3.09679544950127 1.71489210104007e-16 mirMAP -0.471973524573561 5.57397402362044e-07 NA NA NA hsa-miR-30a-5p LRRC58 -1.79779915425811 1.93360169837799e-26 0.530128236797055 1.31502657331592e-06 mirMAP -0.183721355863974 4.77949982853447e-12 NA NA NA hsa-miR-199a-5p LRRC8C -0.364835768178638 0.0435119211101981 1.30268086771407 1.20627043769375e-17 MirTarget;miRanda -0.136212497298324 0.000320847460438954 NA NA NA hsa-miR-30a-5p LRRC8C -1.79779915425811 1.93360169837799e-26 1.30268086771407 1.20627043769375e-17 miRNAWalker2_validate;MirTarget -0.198001125936543 2.24814314516448e-07 NA NA NA hsa-miR-30a-5p LRRC8D -1.79779915425811 1.93360169837799e-26 0.850845800016604 3.48163941100088e-12 MirTarget;miRNATAP -0.114496202515225 0.000175459771103393 NA NA NA hsa-miR-199a-5p LTB4R2 -0.364835768178638 0.0435119211101981 0.0425183787762311 0.839456211273164 miRanda -0.195079402124055 0.000107637899763239 NA NA NA hsa-miR-199a-5p LY6K -0.364835768178638 0.0435119211101981 2.3729948914322 5.36142705420113e-25 miRanda -0.194605432586833 0.00080946939694071 NA NA NA hsa-miR-199a-5p LY75 -0.364835768178638 0.0435119211101981 -0.548410240949248 0.0243027743668825 miRanda -0.199675358674899 0.000668027777737713 NA NA NA hsa-miR-145-5p LYN -0.46917511594055 0.000685297625493134 0.379459023009133 0.0196414558215999 MirTarget -0.188939598531467 0.000221379698291196 NA NA NA hsa-miR-143-5p LYNX1 0.502923736905281 0.00432190530694735 -1.58452439354095 1.30606035949471e-06 mirMAP -0.185859644158916 0.0230291603491647 NA NA NA hsa-miR-143-5p MACC1 0.502923736905281 0.00432190530694735 -2.1260037920145 7.8106118695478e-16 mirMAP -0.161964162977167 0.015882584199732 22533346;23173124 MicroRNA 143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer; Using both in silico prediction and western blot assay we found the previously reported tumor suppressive miR-143 targeted MACC1 in CRC; In concordance with the inhibitory effects induced by siRNA mediated knockdown of MACC1 restoration of miR-143 by mimics in SW620 cells significantly attenuated cell growth migration and invasion; It is notable that combined treatment of miR-143 mimics and MACC1 siRNA induced synergistic inhibitory effects compared to either miR-143 mimics or MACC1 siRNA treatment alone; Furthermore we observed that miR-143 level was inversely correlated with MACC1 mRNA expression in CRC tissues;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker ;metastasis colorectal cancer;colorectal cancer hsa-miR-139-5p MAD2L1 -1.46099200329485 7.85040381494472e-22 1.31598344787194 2.23296117935679e-24 miRanda -0.23799986330838 8.21743682985319e-11 NA NA NA hsa-miR-30a-5p MAF -1.79779915425811 1.93360169837799e-26 0.328206346315223 0.0788517713125687 mirMAP -0.229296097039928 4.42727035007507e-07 NA NA NA hsa-miR-155-5p MAN1A2 0.533437622040649 0.00248671179205372 -0.366569740224287 0.00830801359805642 miRNAWalker2_validate -0.164235323457962 1.39787827771978e-06 NA NA NA hsa-miR-30a-5p MAP3K2 -1.79779915425811 1.93360169837799e-26 0.298189134827425 0.0186234500376514 mirMAP;miRNATAP -0.172921952049398 1.82932319212726e-08 NA NA NA hsa-miR-155-5p MAP4K3 0.533437622040649 0.00248671179205372 -0.0832968976679487 0.368143524727499 MirTarget -0.139210223228112 5.21983593176919e-10 NA NA NA hsa-miR-148a-5p MAP4K4 -1.00478606532747 1.38045244999229e-07 0.53744933005158 3.91532736300518e-07 MirTarget;miRNATAP -0.128052833523055 8.46512367570428e-08 NA NA NA hsa-miR-30a-5p MAPRE1 -1.79779915425811 1.93360169837799e-26 0.477465379670699 1.81939185511159e-11 miRNATAP -0.11693388762789 1.70308062793423e-11 NA NA NA hsa-miR-30a-5p MARCH4 -1.79779915425811 1.93360169837799e-26 2.11310148499518 3.63343736419669e-15 miRNATAP -0.195515009364242 0.00389407674466723 NA NA NA hsa-miR-199a-5p MARCH8 -0.364835768178638 0.0435119211101981 -0.349576221749795 0.0375440685455553 MirTarget -0.102944844056985 0.0111766282428429 NA NA NA hsa-miR-148a-5p MARCKS -1.00478606532747 1.38045244999229e-07 0.375406241267031 0.000227462236788113 MirTarget -0.115101873625095 4.86939971914527e-07 NA NA NA hsa-miR-30a-5p MARK1 -1.79779915425811 1.93360169837799e-26 0.950048876276882 1.00442068476466e-18 mirMAP -0.141159521774684 1.75355739880119e-07 NA NA NA hsa-miR-30a-5p MARK3 -1.79779915425811 1.93360169837799e-26 0.469417009887104 8.80707437592844e-07 miRNATAP -0.204150586654503 3.41302529650269e-19 NA NA NA hsa-miR-199a-5p MARVELD3 -0.364835768178638 0.0435119211101981 0.602053035072131 4.02172118590272e-05 miRanda -0.126415452229069 0.000367870556030743 NA NA NA hsa-miR-30a-5p MAST4 -1.79779915425811 1.93360169837799e-26 -0.959493836763322 6.14042433110317e-07 miRNATAP -0.14936211916355 0.00171214497282189 NA NA NA hsa-miR-155-5p MAVS 0.533437622040649 0.00248671179205372 -0.437338608092888 5.07602915334794e-07 miRNAWalker2_validate -0.120548481378826 1.73085749221576e-08 NA NA NA hsa-miR-145-5p MBNL3 -0.46917511594055 0.000685297625493134 -1.04805770921324 2.07606430324287e-06 miRNATAP -0.213863577732609 0.002319089538004 NA NA NA hsa-miR-199a-5p MBP -0.364835768178638 0.0435119211101981 -0.625299492644183 1.72515918337729e-07 miRanda -0.153872007507298 9.78056579337166e-08 NA NA NA hsa-miR-155-5p MCAM 0.533437622040649 0.00248671179205372 0.780182828447993 3.45688961780472e-08 miRNAWalker2_validate -0.154200717845481 1.12713893159398e-05 NA NA NA hsa-miR-30a-5p MCC -1.79779915425811 1.93360169837799e-26 0.00953690572207666 0.942554122589956 MirTarget;mirMAP -0.158582205333458 7.93869929001636e-07 NA NA NA hsa-miR-199a-5p MCM10 -0.364835768178638 0.0435119211101981 1.75968250716051 1.81507756908239e-30 miRanda -0.206626691499972 1.07483816352661e-07 NA NA NA hsa-miR-338-3p MCM4 -0.948755228846395 8.99167125682392e-08 1.04546514751638 1.52109492147256e-17 MirTarget;miRanda -0.193161803248233 1.71812610632412e-10 NA NA NA hsa-miR-34a-5p MCM4 -0.117372471043915 0.364001947180738 1.04546514751638 1.52109492147256e-17 miRNAWalker2_validate -0.119607823731978 0.00530131327779481 NA NA NA hsa-miR-199a-5p MCTP1 -0.364835768178638 0.0435119211101981 0.952473632839257 1.22786055371195e-05 miRanda -0.10587750121398 0.0459162291909016 NA NA NA hsa-miR-199a-5p MCTP2 -0.364835768178638 0.0435119211101981 0.149859104969983 0.201929474587826 miRanda -0.121813557125229 1.47434423416722e-05 NA NA NA hsa-miR-145-5p MDM2 -0.46917511594055 0.000685297625493134 -0.187608646962063 0.0757851997933277 miRNAWalker2_validate -0.120282167205982 0.000285646785971262 NA NA NA hsa-miR-30a-5p ME1 -1.79779915425811 1.93360169837799e-26 -0.765754120182355 0.000699318109951194 miRNATAP -0.157128055706677 0.00472975612932042 NA NA NA hsa-miR-155-5p MED12L 0.533437622040649 0.00248671179205372 0.390777065496553 0.0832536405719864 miRNATAP -0.238210321771022 1.6856144650401e-05 NA NA NA hsa-miR-155-5p MEF2A 0.533437622040649 0.00248671179205372 -0.201948843854548 0.0486214031081424 miRNAWalker2_validate -0.120470813001856 1.48638914354055e-06 NA NA NA hsa-miR-155-5p MEGF10 0.533437622040649 0.00248671179205372 -0.0918243138549732 0.79807577405778 MirTarget -0.22016618600088 0.0128536425585488 NA NA NA hsa-miR-148a-5p MEMO1 -1.00478606532747 1.38045244999229e-07 0.098190939728191 0.245719021720373 MirTarget -0.149341886593296 7.29102912931712e-16 NA NA NA hsa-miR-155-5p MEST 0.533437622040649 0.00248671179205372 1.00431907071134 9.93717313322278e-08 miRNAWalker2_validate -0.121591798253608 0.00979049307620065 NA NA NA hsa-miR-30a-5p MET -1.79779915425811 1.93360169837799e-26 1.10982494733612 1.35440527522278e-11 miRNAWalker2_validate -0.270438642104152 2.01456359758425e-11 NA NA NA hsa-miR-155-5p MEX3B 0.533437622040649 0.00248671179205372 0.701075362918091 0.000495012215904448 miRNATAP -0.217612902702193 1.13627507004157e-05 NA NA NA hsa-miR-155-5p MFAP3L 0.533437622040649 0.00248671179205372 -0.108888088950732 0.675074858395771 mirMAP -0.234384414615826 0.000239869628854775 NA NA NA hsa-miR-199a-5p MFHAS1 -0.364835768178638 0.0435119211101981 0.802004221351979 2.07063921059535e-05 PITA;miRanda;miRNATAP -0.178141276446401 9.34306616831167e-05 NA NA NA hsa-miR-30a-5p MFHAS1 -1.79779915425811 1.93360169837799e-26 0.802004221351979 2.07063921059535e-05 mirMAP -0.317898785638352 3.25838934290397e-12 NA NA NA hsa-miR-143-5p MGAT4A 0.502923736905281 0.00432190530694735 -1.2217119636503 1.25366377654451e-12 mirMAP -0.112491227061863 0.00964525695099912 NA NA NA hsa-miR-30a-5p MICAL3 -1.79779915425811 1.93360169837799e-26 0.665336980832506 2.20448410112821e-12 mirMAP -0.116797757944355 6.73712252503099e-07 NA NA NA hsa-miR-199a-5p MINK1 -0.364835768178638 0.0435119211101981 -0.0787275836238104 0.457497106147989 miRanda;miRNATAP -0.132948493850043 1.37679730518049e-07 NA NA NA hsa-miR-30a-5p MKRN3 -1.79779915425811 1.93360169837799e-26 0.824231511695552 0.015390487469206 MirTarget -0.215565010479237 0.00993504052474581 NA NA NA hsa-miR-193b-5p MLLT6 1.10486595354104 6.41489920661805e-11 -0.576328122625482 2.72701741000203e-09 mirMAP -0.205588079771048 1.48801530314822e-17 NA NA NA hsa-miR-199a-5p MMACHC -0.364835768178638 0.0435119211101981 -0.0949950229428578 0.36284399307679 miRanda -0.135379485452633 5.03782906201743e-08 NA NA NA hsa-miR-148a-5p MME -1.00478606532747 1.38045244999229e-07 0.739128691283019 0.017041473154203 mirMAP -0.221626325759268 0.00154877755703877 NA NA NA hsa-miR-30a-5p MME -1.79779915425811 1.93360169837799e-26 0.739128691283019 0.017041473154203 mirMAP -0.177141899557197 0.0200661801065863 NA NA NA hsa-miR-145-5p MMP12 -0.46917511594055 0.000685297625493134 6.88838790610627 5.81791584756413e-21 miRNAWalker2_validate -0.421754395212502 0.0482238115681261 NA NA NA hsa-miR-155-5p MMP16 0.533437622040649 0.00248671179205372 1.2559566792111 2.18447072152097e-05 mirMAP -0.43185435980844 2.64215093272054e-09 NA NA NA hsa-miR-199a-5p MMP25 -0.364835768178638 0.0435119211101981 0.688777556750725 0.000451114544458042 miRanda -0.120866946966282 0.0110908168254567 NA NA NA hsa-miR-30a-5p MNT -1.79779915425811 1.93360169837799e-26 -0.121065671349005 0.1462181968759 miRNATAP -0.123257564190923 8.08166899147419e-10 NA NA NA hsa-miR-30a-5p MON1B -1.79779915425811 1.93360169837799e-26 0.0455158150620631 0.559339100092923 mirMAP -0.109240318798208 6.00556186570708e-09 NA NA NA hsa-miR-199a-5p MPHOSPH9 -0.364835768178638 0.0435119211101981 0.557042849598225 1.36995054039031e-05 miRanda -0.102984254683142 0.000909993969519867 NA NA NA hsa-miR-155-5p MPP5 0.533437622040649 0.00248671179205372 -0.66105069147757 1.48685734474872e-12 miRNAWalker2_validate;MirTarget -0.120133199126731 2.49362867717843e-07 NA NA NA hsa-miR-199a-5p MPP5 -0.364835768178638 0.0435119211101981 -0.66105069147757 1.48685734474872e-12 MirTarget;PITA;miRanda;miRNATAP -0.124209057479831 4.713778962537e-08 NA NA NA hsa-miR-155-5p MSI2 0.533437622040649 0.00248671179205372 -0.0612227681709423 0.635780859475999 miRNAWalker2_validate -0.112836097146874 0.000376322659725738 NA NA NA hsa-miR-30a-5p MTDH -1.79779915425811 1.93360169837799e-26 0.378364061756277 7.4488995497114e-07 miRNAWalker2_validate;miRNATAP -0.154525464021008 3.08399597841023e-17 25484183;26589417;23851509 AEG 1 3' untranslated region functions as a ceRNA in inducing epithelial mesenchymal transition of human non small cell lung cancer by regulating miR 30a activity;Luciferase assay showed that metadherin MTDH mRNA was a direct target of miR-30a-5p; A significant reverse correlation between miR-30a-5p and MTDH in liver cancer tissues was observed; miR-30a-5p overexpression in HCC cells significantly inhibited cell proliferation colon formation and induced apoptosis while MTDH overexpression reversed growth inhibition and apoptosis induction of miRNA-30a-5p in HCC cells; Our results suggest that underexpression of miR-30a-5p might function as a tumor suppressing miRNA by directly targeting MTDH in HCC and is therefore a potential candidate biomarker for HCC targeting therapy;MicroRNA 30a suppresses breast tumor growth and metastasis by targeting metadherin; Furthermore we demonstrated that silence of MTDH could recapitulate the effects of miR-30a overexpression while overexpression of MTDH could partially abrogate miR-30a-mediated suppression; Taken together our findings indicated miR-30a inhibits breast cancer proliferation and metastasis by directly targeting MTDH and miR-30a can serve as a prognostic marker for breast cancer ;;metastasis lung squamous cell cancer;liver cancer;breast cancer hsa-miR-199a-5p MTMR1 -0.364835768178638 0.0435119211101981 -0.0857253224120695 0.412906395557814 miRanda -0.10759151217494 1.73912217550995e-05 NA NA NA hsa-miR-30a-5p MTSS1 -1.79779915425811 1.93360169837799e-26 0.415797615023809 0.00666959505931445 mirMAP -0.272667714472787 1.29001336053234e-13 NA NA NA hsa-miR-145-5p MUC1 -0.46917511594055 0.000685297625493134 -1.17201758319527 2.23094627348643e-05 miRNAWalker2_validate;miRTarBase -0.312266507937271 0.000362027609499469 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-199a-5p MUC21 -0.364835768178638 0.0435119211101981 -7.89637660108391 2.12621213926786e-27 MirTarget;miRanda -0.420612218662331 0.0234768382443933 NA NA NA hsa-miR-155-5p MUT 0.533437622040649 0.00248671179205372 -0.52060696357821 8.48975874500113e-10 miRNAWalker2_validate -0.118009665857627 1.80864436240757e-08 23715647 The regulation of Mut L homologue 1 MLH1 expression by microRNA miR-155 and its prognostic significance in pancreatic cancer PC remain to be elucidated pancreatic cancer hsa-miR-143-5p MXD1 0.502923736905281 0.00432190530694735 -0.572225804275934 0.00401648067133565 MirTarget -0.13019633211243 0.00819951321636111 NA NA NA hsa-miR-148a-5p MXD1 -1.00478606532747 1.38045244999229e-07 -0.572225804275934 0.00401648067133565 mirMAP -0.125792974926961 0.00522022013001649 NA NA NA hsa-miR-30a-5p MYBL2 -1.79779915425811 1.93360169837799e-26 2.33768994347438 1.23651983433918e-50 MirTarget;miRNATAP -0.333107423924901 6.80296713005357e-16 NA NA NA hsa-miR-145-5p MYC -0.46917511594055 0.000685297625493134 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.100138529937553 0.0231733444001464 23919393;21836381;23499891;24356567;21092188;21690566;21723890;27482839 MicroRNA 145 function as a cell growth repressor by directly targeting c Myc in human ovarian cancer; We show that miR-145 directly target the c-Myc 3'-UTR; Moreover ectopic expression of c-Myc reduces the inhibition of cell proliferation caused by miR-145 transfection; Cell cycle assay showed that up-regulation of miR-145 reduces S phase population and restoration of c-Myc can rescue this reduction; These findings indicate that miR-145 inhibits cell proliferation and promotes cell apoptosis by targeting c-Myc 3'-UTR;The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC and in human melanoma A2058 and Mewo cells;The ectopic expression of miR-145 inhibited the growth of DLD-1 cells by disturbing β-catenin translocation into the nucleus thereby leading to the down-regulation of LEF/TCF transcriptional target genes c-Myc and CyclinD1;miR 145 inhibits proliferation and invasion of esophageal squamous cell carcinoma in part by targeting c Myc; The impact of overexpression of miR-145 on putative target c-Myc was subsequently confirmed via Western blot; Overexpression of miR-145 significantly decreased p < 0.05 the protein level of c-Myc which has previously been identified as a direct target of miR-145; Our results demonstrate that overexpression of miR-145 inhibits tumor growth in part by targeting c-Myc;In colon cancer cells c-Myc is a confirmed direct target for miR-145; The aim of this work was to investigate the effect of miR-145 and c-Myc on proliferation of NSCLC cells using the NSCLC cell lines A549 and H23 as models; We further showed that c-Myc was a direct target for miR-145; Taken together our study results demonstrate that miR-145 inhibits proliferation of NSCLC cells through c-Myc;miR-145 delivery reduced tumor proliferation and increased apoptosis with concomitant repression of c-Myc and ERK5 as novel regulatory target of miR-145;We found a reverse-correlation between the expression of miR-145 and its target genes such as fascin-1 c-myc SMAD2/3 and IGF-1R in breast cancer cell lines and breast cancer patient tissues;Consequently the increased miR-145 induced G1 cell cycle arrest reduced tumor proliferation and increased apoptosis inhibited HCT-116 cell migration and suppressed c-MYC expressions a regulatory target of miR-145 ;;;;;;;cell migration ovarian cancer;melanoma;colon cancer;esophageal cancer;lung squamous cell cancer;colon cancer;breast cancer;colon cancer hsa-miR-199a-5p MYCBP2 -0.364835768178638 0.0435119211101981 -0.53919704068195 0.00020848748450353 miRanda -0.103275513725871 0.00335397233552506 NA NA NA hsa-miR-30a-5p MYH10 -1.79779915425811 1.93360169837799e-26 0.854580993440036 1.81707772343095e-05 miRNATAP -0.252273923952206 2.35723765524996e-07 NA NA NA hsa-miR-30a-5p MYH9 -1.79779915425811 1.93360169837799e-26 0.558082493758668 1.58004830224951e-06 miRNATAP -0.208647113121627 1.12731606338729e-13 NA NA NA hsa-miR-155-5p MYO10 0.533437622040649 0.00248671179205372 1.19638438303499 2.8751575069756e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.208452421764518 1.57805854729851e-09 NA NA NA hsa-miR-30a-5p MYO10 -1.79779915425811 1.93360169837799e-26 1.19638438303499 2.8751575069756e-18 miRNAWalker2_validate -0.266097014662018 4.4688378412709e-15 NA NA NA hsa-miR-199a-5p MYO19 -0.364835768178638 0.0435119211101981 0.523189568916779 1.46652271499222e-09 MirTarget;miRanda -0.103785766985438 7.40221351102993e-07 NA NA NA hsa-miR-155-5p MYO1D 0.533437622040649 0.00248671179205372 -0.138881254957447 0.158663019912855 miRNAWalker2_validate;miRNATAP -0.154078724224218 1.0286178349296e-10 NA NA NA hsa-miR-199a-5p MYO1G -0.364835768178638 0.0435119211101981 0.95519574867813 2.9713371189685e-06 miRanda -0.136081450525452 0.00623381538539668 NA NA NA hsa-miR-148a-5p MYO5A -1.00478606532747 1.38045244999229e-07 0.869833872891447 9.96151516924446e-08 mirMAP -0.132816326151025 0.000359561014153079 NA NA NA hsa-miR-30a-5p MYO5A -1.79779915425811 1.93360169837799e-26 0.869833872891447 9.96151516924446e-08 mirMAP;miRNATAP -0.353391405424517 1.66714057153076e-19 NA NA NA hsa-miR-30a-5p MYO9A -1.79779915425811 1.93360169837799e-26 -0.486575638682708 0.00579660479460535 mirMAP -0.123312221902261 0.00442479731682605 NA NA NA hsa-miR-30a-5p N4BP2 -1.79779915425811 1.93360169837799e-26 -0.44700596253432 0.0285397038392257 miRNATAP -0.134251699979697 0.00738872286488197 NA NA NA hsa-miR-193b-5p NAALADL2 1.10486595354104 6.41489920661805e-11 -1.82004129149567 1.23004676896527e-08 MirTarget -0.828802357945474 2.79469818532197e-26 NA NA NA hsa-miR-199a-5p NAB1 -0.364835768178638 0.0435119211101981 0.421525132196162 7.63770203605851e-05 miRanda -0.110795467943217 1.5944748419819e-05 NA NA NA hsa-miR-155-5p NAMPT 0.533437622040649 0.00248671179205372 -0.739258425623817 3.22594780704023e-06 miRNAWalker2_validate;miRNATAP -0.138563723356398 0.000437076666227053 NA NA NA hsa-miR-199a-5p NAT1 -0.364835768178638 0.0435119211101981 -0.367974324052864 0.00505004714712608 miRanda -0.135127147646724 1.82654147467635e-05 NA NA NA hsa-miR-30a-5p NAV1 -1.79779915425811 1.93360169837799e-26 1.02688028759683 4.56434548971228e-10 mirMAP;miRNATAP -0.329778696299934 1.43856246436428e-16 NA NA NA hsa-miR-134-5p NCAPG -0.598302069876985 0.00124773585997939 1.61620045991199 7.33967056673124e-34 MirTarget -0.107386491179262 0.00127465874945002 NA NA NA hsa-miR-30e-3p NCAPG -0.890635378639789 1.65740480611339e-16 1.61620045991199 7.33967056673124e-34 mirMAP -0.193498910351498 0.000550728337147188 NA NA NA hsa-miR-374a-5p NCAPG -0.621903385111545 6.61791773205282e-12 1.61620045991199 7.33967056673124e-34 mirMAP -0.181963713895565 0.0073845902015019 NA NA NA hsa-miR-378c NCAPG -1.82618708894602 7.26454201089171e-22 1.61620045991199 7.33967056673124e-34 MirTarget -0.138989912474989 8.06436919663001e-06 NA NA NA hsa-miR-155-5p NCKAP1 0.533437622040649 0.00248671179205372 -0.223200734771987 0.0423254140187921 miRNAWalker2_validate -0.24167588117103 2.05326819034794e-20 NA NA NA hsa-miR-30a-5p NCKAP1 -1.79779915425811 1.93360169837799e-26 -0.223200734771987 0.0423254140187921 miRNAWalker2_validate -0.139589094253332 1.67124791682157e-07 NA NA NA hsa-miR-199a-5p NCOA2 -0.364835768178638 0.0435119211101981 -0.813100952711397 0.00129941915641853 PITA;miRanda;miRNATAP -0.24472847589126 5.95499881742915e-05 NA NA NA hsa-miR-199a-5p NCOR1 -0.364835768178638 0.0435119211101981 -0.41715562912205 0.000105306408142708 MirTarget;miRNATAP -0.116597131380348 6.68341747541862e-06 NA NA NA hsa-miR-30a-5p NCS1 -1.79779915425811 1.93360169837799e-26 0.834207780927169 1.52344188788995e-12 miRNATAP -0.155482052429415 1.06393278193287e-07 NA NA NA hsa-miR-199a-5p NDE1 -0.364835768178638 0.0435119211101981 1.10063690688043 3.23484844125247e-25 miRanda -0.172389964980246 6.43870057571946e-11 NA NA NA hsa-miR-30a-5p NDE1 -1.79779915425811 1.93360169837799e-26 1.10063690688043 3.23484844125247e-25 miRNAWalker2_validate -0.233100096608397 1.0140280877785e-18 NA NA NA hsa-miR-30a-5p NDEL1 -1.79779915425811 1.93360169837799e-26 -0.180434796502483 0.141282300692093 miRNAWalker2_validate;MirTarget;miRNATAP -0.176071767516641 2.84133513692099e-09 NA NA NA hsa-miR-30a-5p NEDD4 -1.79779915425811 1.93360169837799e-26 0.280662483817165 0.0460478353802535 MirTarget;miRNATAP -0.111609518870968 0.00119428535942061 NA NA NA hsa-miR-30a-5p NEFL -1.79779915425811 1.93360169837799e-26 2.25227626191513 3.06858972822193e-06 MirTarget -0.687265681650004 5.76931437983497e-09 NA NA NA hsa-miR-30a-5p NEFM -1.79779915425811 1.93360169837799e-26 -0.294758123307522 0.611010624120708 MirTarget -0.360097369171642 0.0112770889140357 NA NA NA hsa-miR-155-5p NES 0.533437622040649 0.00248671179205372 0.235389511193367 0.319422694268662 miRNAWalker2_validate -0.135435862051043 0.0202280577918061 NA NA NA hsa-miR-199a-5p NEU3 -0.364835768178638 0.0435119211101981 -0.323814713360852 0.0962293039927071 miRanda -0.117986516585753 0.0120132510438702 NA NA NA hsa-miR-30a-5p NFASC -1.79779915425811 1.93360169837799e-26 -0.462135182741144 0.0180702936464523 mirMAP -0.155141902273166 0.00120866775337408 NA NA NA hsa-miR-155-5p NFAT5 0.533437622040649 0.00248671179205372 -0.144057691414319 0.161686730526662 mirMAP;miRNATAP -0.106013680019205 2.59274713106684e-05 NA NA NA hsa-miR-199a-5p NFATC2IP -0.364835768178638 0.0435119211101981 0.383097162395623 2.48850530746239e-08 miRanda -0.10522608874614 1.57446750707094e-10 NA NA NA hsa-miR-199a-5p NFE2L3 -0.364835768178638 0.0435119211101981 1.24831947462375 1.35440798789154e-09 miRanda -0.104193892233925 0.039331305966995 NA NA NA hsa-miR-193b-5p NFIX 1.10486595354104 6.41489920661805e-11 -1.84194483258865 3.52118694554722e-40 mirMAP -0.205805428453659 4.66183477111506e-08 NA NA NA hsa-miR-155-5p NGEF 0.533437622040649 0.00248671179205372 -0.347890271628979 0.22536420672004 miRNATAP -0.364185252970489 2.03840930373334e-07 NA NA NA hsa-miR-30a-5p NID1 -1.79779915425811 1.93360169837799e-26 2.07134473790095 1.56817711018363e-17 miRNATAP -0.243811155253525 7.11147313862304e-05 NA NA NA hsa-miR-30a-5p NID2 -1.79779915425811 1.93360169837799e-26 2.26708965985908 3.63635606732703e-22 miRNATAP -0.257307893569909 1.59729036762749e-05 NA NA NA hsa-miR-30a-5p NIP7 -1.79779915425811 1.93360169837799e-26 0.346028900559304 0.000171813335822453 miRNAWalker2_validate -0.161279054273865 3.41063231503494e-13 NA NA NA hsa-miR-30a-5p NIPA1 -1.79779915425811 1.93360169837799e-26 0.755630796037288 8.27563977875826e-11 mirMAP -0.195206864983486 7.25874926188785e-12 NA NA NA hsa-miR-199a-5p NIPAL1 -0.364835768178638 0.0435119211101981 -1.35899811766334 1.03109952969324e-06 miRanda -0.23591650065606 0.000486537878220903 NA NA NA hsa-miR-30a-5p NIPAL1 -1.79779915425811 1.93360169837799e-26 -1.35899811766334 1.03109952969324e-06 mirMAP -0.27744085642973 5.29417660495744e-05 NA NA NA hsa-miR-30a-5p NLN -1.79779915425811 1.93360169837799e-26 0.25472909474603 0.0232886592147819 mirMAP -0.142371436098486 1.77000570325628e-07 NA NA NA hsa-miR-155-5p NMD3 0.533437622040649 0.00248671179205372 0.155675847752497 0.0607760427762586 miRNAWalker2_validate -0.118336337299218 4.27540304228893e-09 NA NA NA hsa-miR-155-5p NNT 0.533437622040649 0.00248671179205372 -0.996414005796716 3.05705988490518e-11 mirMAP -0.160516218189025 1.86936439358466e-05 NA NA NA hsa-miR-148a-5p NOX5 -1.00478606532747 1.38045244999229e-07 0.691252404193988 0.0208340296475449 mirMAP -0.345479757816604 2.57755253898807e-07 NA NA NA hsa-miR-199a-5p NPNT -0.364835768178638 0.0435119211101981 1.38847423600513 1.51217763958235e-10 miRanda -0.125630947785552 0.0184245285870969 NA NA NA hsa-miR-30a-5p NR3C1 -1.79779915425811 1.93360169837799e-26 0.119235037257651 0.221137807826121 miRNATAP -0.105476014143695 8.4762159090378e-06 NA NA NA hsa-miR-30a-5p NR6A1 -1.79779915425811 1.93360169837799e-26 0.0960369431420759 0.565158937269813 miRNATAP -0.174702861729987 1.74215143525042e-05 NA NA NA hsa-miR-145-5p NRAS -0.46917511594055 0.000685297625493134 0.398384760345124 2.73206950817875e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.127512559718541 2.02648627117484e-05 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-30a-5p NRBF2 -1.79779915425811 1.93360169837799e-26 0.299502131686497 0.00257402143089791 miRNATAP -0.162927883223957 1.00104117307177e-11 NA NA NA hsa-miR-200b-3p NRG1 0.0717138787925347 0.682858087587209 1.67312629061776 2.25625233548643e-09 TargetScan -0.147917675029035 0.0368809811124626 NA NA NA hsa-miR-28-5p NRG1 -0.026996999089909 0.733047113251652 1.67312629061776 2.25625233548643e-09 PITA;miRanda -0.56639349107998 0.00037357838203679 NA NA NA hsa-miR-320a NRG2 0.801356001806321 4.91397101474502e-09 -4.26822827719143 4.49293558737342e-48 miRanda;mirMAP -0.456459494723934 6.10405869598189e-06 NA NA NA hsa-miR-320b NRG2 1.23473838180754 3.04337566045537e-14 -4.26822827719143 4.49293558737342e-48 miRanda;mirMAP -0.465487147295013 2.51204455514913e-08 NA NA NA hsa-miR-3607-3p NRG2 1.01377165357363 9.13355519701165e-05 -4.26822827719143 4.49293558737342e-48 MirTarget;miRNATAP -0.153309681669252 0.00448653743827493 NA NA NA hsa-miR-3934-5p NRG2 1.48601805685912 2.33872147099905e-17 -4.26822827719143 4.49293558737342e-48 MirTarget -0.507804006857417 1.93517098682273e-10 NA NA NA hsa-miR-421 NRG2 0.945488088619653 2.35762398527362e-09 -4.26822827719143 4.49293558737342e-48 miRNATAP -0.393995820058102 6.50396524347151e-06 NA NA NA hsa-miR-30a-5p NRIP1 -1.79779915425811 1.93360169837799e-26 0.0713643770033592 0.666160256380717 MirTarget;miRNATAP -0.218471099067221 4.98940783347051e-08 NA NA NA hsa-miR-148a-5p NT5E -1.00478606532747 1.38045244999229e-07 1.15633838740041 3.09618724999389e-05 miRNATAP -0.282391675649606 6.81830987317998e-06 NA NA NA hsa-miR-30a-5p NT5E -1.79779915425811 1.93360169837799e-26 1.15633838740041 3.09618724999389e-05 miRNAWalker2_validate;miRNATAP -0.219126179984582 0.00137293682937576 NA NA NA hsa-miR-30a-5p NTM -1.79779915425811 1.93360169837799e-26 1.83000529362359 6.50446454494725e-15 miRNATAP -0.205601519014622 0.000499405477393462 NA NA NA hsa-miR-155-5p NTRK2 0.533437622040649 0.00248671179205372 -1.11513528054371 0.0139689274900379 mirMAP -0.290455272050116 0.00960861019429555 NA NA NA hsa-miR-145-5p NUDT1 -0.46917511594055 0.000685297625493134 1.06568336974934 6.60377632545965e-15 miRTarBase -0.113634652224052 0.0102979124027188 21289483 MiR 145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1; The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells; Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels; Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1; Our findings provided new insight into the complex regulating pathway comprising of miR-145 EGFR NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis lung cancer hsa-miR-193b-5p NUDT16 1.10486595354104 6.41489920661805e-11 -0.211000888611348 0.0334901298488528 mirMAP -0.155010865249862 3.57193013421526e-10 NA NA NA hsa-miR-199a-5p NUP98 -0.364835768178638 0.0435119211101981 -0.0281371048250163 0.726653660187243 miRanda -0.114456459598023 1.8840966661727e-09 NA NA NA hsa-miR-199a-5p OAS1 -0.364835768178638 0.0435119211101981 0.73512009506168 0.000204186134996198 miRanda -0.224392681559313 2.49300332726608e-06 NA NA NA hsa-miR-199a-5p OAS3 -0.364835768178638 0.0435119211101981 1.54728921914282 1.16949478961224e-13 miRanda -0.316792598193051 4.45116954569329e-10 NA NA NA hsa-miR-199a-5p OASL -0.364835768178638 0.0435119211101981 2.53547484407276 5.8851605284789e-17 miRanda -0.363620713175486 1.20196379029978e-06 NA NA NA hsa-miR-155-5p OBSCN 0.533437622040649 0.00248671179205372 -1.73677709338981 1.04326911517838e-13 miRNAWalker2_validate -0.208086707318474 0.000413518777397865 NA NA NA hsa-miR-145-5p ONECUT2 -0.46917511594055 0.000685297625493134 2.77508854336496 2.81944963572594e-17 mirMAP;miRNATAP -0.353960506464684 0.000913326003159695 NA NA NA hsa-miR-199a-5p ONECUT2 -0.364835768178638 0.0435119211101981 2.77508854336496 2.81944963572594e-17 PITA;miRNATAP -0.293440102851518 0.000323243949807194 NA NA NA hsa-miR-30a-5p ONECUT2 -1.79779915425811 1.93360169837799e-26 2.77508854336496 2.81944963572594e-17 mirMAP;miRNATAP -0.230852381770891 0.00551598218490911 NA NA NA hsa-miR-155-5p OSR1 0.533437622040649 0.00248671179205372 -2.1186562627557 6.07059103794627e-13 miRNATAP -0.237643590516911 0.00136445025111047 NA NA NA hsa-miR-199a-5p OTUB2 -0.364835768178638 0.0435119211101981 -0.128945274818751 0.47287634839738 miRanda -0.128814321788089 0.00289220632194925 NA NA NA hsa-miR-155-5p OTUD7B 0.533437622040649 0.00248671179205372 -0.0927588514698865 0.258220548545569 mirMAP -0.122315546350553 7.25685711739747e-10 NA NA NA hsa-miR-199a-5p P2RY2 -0.364835768178638 0.0435119211101981 -1.06512981296937 1.5087795199613e-07 miRanda -0.160082537379689 0.0012004819574672 NA NA NA hsa-miR-148a-5p P4HA1 -1.00478606532747 1.38045244999229e-07 1.40117250238898 6.82766432996812e-24 MirTarget -0.145426480351341 8.56256082983366e-06 NA NA NA hsa-miR-30a-5p P4HA1 -1.79779915425811 1.93360169837799e-26 1.40117250238898 6.82766432996812e-24 mirMAP;miRNATAP -0.139280843920484 8.94383670083527e-05 NA NA NA hsa-miR-30a-5p P4HA2 -1.79779915425811 1.93360169837799e-26 1.14262037141911 8.0765247106919e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.188504038764414 7.71917622154794e-07 NA NA NA hsa-miR-30a-5p PAFAH1B2 -1.79779915425811 1.93360169837799e-26 -0.0086208610020817 0.955052166896747 miRNAWalker2_validate;MirTarget -0.186541962710681 5.03519469194385e-07 NA NA NA hsa-miR-30a-5p PAICS -1.79779915425811 1.93360169837799e-26 0.556351129554198 6.82433536000135e-09 miRNAWalker2_validate -0.128028820209503 5.6839298439514e-08 NA NA NA hsa-miR-199a-5p PAK1 -0.364835768178638 0.0435119211101981 0.447978132304134 0.000120547414290664 miRanda -0.109400729243876 9.99089479586017e-05 NA NA NA hsa-miR-155-5p PALLD 0.533437622040649 0.00248671179205372 -0.102378917097386 0.426549653854515 miRNAWalker2_validate -0.213957517979988 5.94433476916003e-12 NA NA NA hsa-miR-155-5p PANK1 0.533437622040649 0.00248671179205372 -0.946939560303033 3.06184790322995e-10 miRNATAP -0.137024655481676 0.000270603325960381 NA NA NA hsa-miR-155-5p PANK3 0.533437622040649 0.00248671179205372 -0.0279389989944399 0.790084990756226 mirMAP -0.115793301721884 6.30579613872086e-06 NA NA NA hsa-miR-30a-5p PAPD5 -1.79779915425811 1.93360169837799e-26 0.116699534733909 0.187111347734983 mirMAP -0.129723813818444 1.15934237066007e-09 NA NA NA hsa-miR-30a-5p PAPOLG -1.79779915425811 1.93360169837799e-26 0.314678464687046 0.000273034705525692 MirTarget -0.110569139755411 1.47520204547346e-07 NA NA NA hsa-miR-199a-5p PAQR4 -0.364835768178638 0.0435119211101981 1.06349226005624 1.74537713691781e-18 miRanda -0.1265355301923 2.61922275561289e-05 NA NA NA hsa-miR-30a-5p PAQR5 -1.79779915425811 1.93360169837799e-26 -0.234005897375279 0.422462908039566 mirMAP -0.398300397069454 1.74091832598868e-08 NA NA NA hsa-miR-199a-5p PARP12 -0.364835768178638 0.0435119211101981 1.44736283935429 3.00231420538446e-28 MirTarget;miRanda;miRNATAP -0.148571416482254 7.90911063067705e-06 NA NA NA hsa-miR-30a-5p PARP9 -1.79779915425811 1.93360169837799e-26 0.648730243031073 9.25264492610199e-06 mirMAP -0.19011617864281 1.0854251675293e-07 NA NA NA hsa-miR-30a-5p PAWR -1.79779915425811 1.93360169837799e-26 0.541083404138069 1.32291645667673e-07 MirTarget;mirMAP -0.224898634971699 4.28239813051408e-20 NA NA NA hsa-miR-193b-5p PCBD1 1.10486595354104 6.41489920661805e-11 -0.373423072574184 0.0007848490869947 MirTarget -0.217453570492324 2.62133664750353e-15 NA NA NA hsa-miR-30a-5p PCDH17 -1.79779915425811 1.93360169837799e-26 1.64710631912331 3.4649462512587e-14 MirTarget;miRNATAP -0.234757766096824 1.59507452298459e-05 NA NA NA hsa-miR-155-5p PCDH9 0.533437622040649 0.00248671179205372 -1.15280608292411 0.000207025261963558 miRNAWalker2_validate;MirTarget;miRNATAP -0.276860013600681 0.000315471289377779 NA NA NA hsa-miR-155-5p PCSK5 0.533437622040649 0.00248671179205372 -0.721047151572528 0.00983189948521875 mirMAP -0.21143506849327 0.00217124019816293 NA NA NA hsa-miR-155-5p PCYOX1 0.533437622040649 0.00248671179205372 -0.592579666766851 2.15233934529186e-09 miRNAWalker2_validate -0.234557471996235 4.55601819676475e-23 NA NA NA hsa-miR-30a-5p PDCD10 -1.79779915425811 1.93360169837799e-26 0.522103014094339 4.27838280479279e-09 miRNAWalker2_validate;miRNATAP -0.142127443858258 5.75587634708773e-11 NA NA NA hsa-miR-148a-5p PDCD5 -1.00478606532747 1.38045244999229e-07 0.507666418689669 6.1092467400712e-07 MirTarget -0.177490847676093 4.00134148418143e-15 NA NA NA hsa-miR-155-5p PDE3A 0.533437622040649 0.00248671179205372 0.361007237788253 0.240290495534676 miRNAWalker2_validate -0.435448052172971 5.97808779831824e-09 NA NA NA hsa-miR-155-5p PDK1 0.533437622040649 0.00248671179205372 0.623371470189504 3.44523933291882e-06 miRNAWalker2_validate -0.109232784740243 0.00104858494460743 NA NA NA hsa-miR-155-5p PDLIM5 0.533437622040649 0.00248671179205372 -0.992443646461865 8.0957032725133e-19 miRNAWalker2_validate;miRTarBase -0.178822059496078 2.10814613928506e-10 NA NA NA hsa-miR-30a-5p PDLIM7 -1.79779915425811 1.93360169837799e-26 1.07874929400589 6.16535547507172e-12 miRNAWalker2_validate -0.144824050694614 0.000217222445019499 NA NA NA hsa-miR-30a-5p PDP2 -1.79779915425811 1.93360169837799e-26 -0.21487572574213 0.119795198854145 miRNATAP -0.143405203264894 2.05009908383191e-05 NA NA NA hsa-miR-155-5p PDPR 0.533437622040649 0.00248671179205372 -0.049283770635121 0.76286814892336 miRNAWalker2_validate -0.158628013005136 7.50085052746528e-05 NA NA NA hsa-miR-199a-5p PDSS1 -0.364835768178638 0.0435119211101981 0.00290998020855504 0.976806319054876 miRanda -0.132545791377789 2.51284876597276e-08 NA NA NA hsa-miR-155-5p PEG3 0.533437622040649 0.00248671179205372 -3.175105478717 6.72316372411781e-22 miRNATAP -0.240334124105486 0.00466354596139777 NA NA NA hsa-miR-155-5p PELI1 0.533437622040649 0.00248671179205372 -0.622622223115394 1.09214642993034e-05 miRNAWalker2_validate;miRNATAP -0.162440917550518 3.30569126241761e-06 NA NA NA hsa-miR-193b-5p PER2 1.10486595354104 6.41489920661805e-11 -1.01554672029808 2.39471125617259e-13 mirMAP -0.162931292046281 5.04723562133878e-06 NA NA NA hsa-miR-30a-5p PES1 -1.79779915425811 1.93360169837799e-26 0.513266130683119 5.41982053939145e-08 miRNAWalker2_validate -0.10004469070417 1.70810222351654e-05 NA NA NA hsa-miR-155-5p PFKFB2 0.533437622040649 0.00248671179205372 -0.194533917224863 0.108056045906794 mirMAP -0.241539826750931 7.19971081025364e-17 NA NA NA hsa-miR-30a-5p PFKFB4 -1.79779915425811 1.93360169837799e-26 0.830125036863078 2.35641150585505e-08 mirMAP -0.181377359498137 7.38411624865345e-07 NA NA NA hsa-miR-30a-5p PFN2 -1.79779915425811 1.93360169837799e-26 0.845395635202429 0.000285264834672102 MirTarget;miRNATAP -0.159577141302235 0.00545583603461197 NA NA NA hsa-miR-155-5p PGAP1 0.533437622040649 0.00248671179205372 0.0725665033338698 0.609795927225641 mirMAP -0.122433687074692 0.000454220125751509 NA NA NA hsa-miR-30a-5p PGM2 -1.79779915425811 1.93360169837799e-26 -0.310691488774575 0.0203617021510368 MirTarget -0.1615019467681 7.21853917004959e-07 NA NA NA hsa-miR-155-5p PHEX 0.533437622040649 0.00248671179205372 0.593600352272469 0.0118549344170783 MirTarget -0.152934907001759 0.0087111523341435 NA NA NA hsa-miR-199a-5p PHF6 -0.364835768178638 0.0435119211101981 0.350259171777161 0.000319637529119767 PITA;miRanda -0.121540749739312 1.85080756671916e-07 NA NA NA hsa-miR-30a-5p PHLDA2 -1.79779915425811 1.93360169837799e-26 0.351016376109103 0.0401564101954058 miRNAWalker2_validate -0.224582304795649 6.3876680963023e-08 NA NA NA hsa-miR-199a-5p PIK3CD -0.364835768178638 0.0435119211101981 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.10392905863127 0.00413232021656056 NA NA NA hsa-miR-30a-5p PIK3CD -1.79779915425811 1.93360169837799e-26 1.09936669850841 6.53933580961931e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.215181764255274 3.32715363881856e-09 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30a-5p PITPNM2 -1.79779915425811 1.93360169837799e-26 0.388671501999739 0.000653891741170112 MirTarget;miRNATAP -0.155976148471278 1.83662253632686e-08 NA NA NA hsa-miR-30a-5p PITPNM3 -1.79779915425811 1.93360169837799e-26 -0.573533465961102 0.000783751151651619 MirTarget -0.125984271700428 0.00270751987701293 NA NA NA hsa-miR-199a-5p PKN2 -0.364835768178638 0.0435119211101981 -0.114436217089763 0.199973357722777 miRNATAP -0.125449783674557 3.15686327406643e-09 NA NA NA hsa-miR-199a-5p PLA2G4D -0.364835768178638 0.0435119211101981 -0.153373370642905 0.728117922553825 miRanda -0.231721425652653 0.0295300476213567 NA NA NA hsa-miR-155-5p PLAG1 0.533437622040649 0.00248671179205372 0.72233061816166 0.00956326010465735 miRNATAP -0.326691857537461 1.78484543853428e-06 NA NA NA hsa-miR-30a-5p PLAGL2 -1.79779915425811 1.93360169837799e-26 0.18699265480412 0.0869475518283709 MirTarget;miRNATAP -0.12447614644407 2.78054121160637e-06 NA NA NA hsa-miR-199a-5p PLEK2 -0.364835768178638 0.0435119211101981 1.70276541098005 2.66162096002366e-15 miRanda -0.222182708926025 2.94660129453649e-05 NA NA NA hsa-miR-155-5p PLEKHA1 0.533437622040649 0.00248671179205372 -0.0562300917680822 0.622039355113115 MirTarget -0.18663015528156 1.24144583149714e-11 NA NA NA hsa-miR-155-5p PLEKHA5 0.533437622040649 0.00248671179205372 -0.27957849011877 0.0220555260142062 miRNAWalker2_validate -0.134402717800009 7.1170369938139e-06 NA NA NA hsa-miR-199a-5p PLEKHF2 -0.364835768178638 0.0435119211101981 0.11697761404611 0.202352161370775 MirTarget;miRanda -0.132653091361562 1.06071520334707e-09 NA NA NA hsa-miR-155-5p PLEKHG4B 0.533437622040649 0.00248671179205372 2.19521988902811 2.59070130073853e-11 mirMAP -0.221937853628194 0.00739504546818858 NA NA NA hsa-miR-145-5p PLEKHG7 -0.46917511594055 0.000685297625493134 -0.283181677423478 0.409057482780811 MirTarget -0.316237074450623 0.00341139227531958 NA NA NA hsa-miR-199a-5p PLEKHH1 -0.364835768178638 0.0435119211101981 -0.657202382455656 0.000304425532234905 miRanda;miRNATAP -0.257885760396662 3.11096631115528e-09 NA NA NA hsa-miR-193b-5p PLEKHH2 1.10486595354104 6.41489920661805e-11 -0.257843336465871 0.232615888305904 MirTarget -0.28034295040618 2.27215510406386e-07 NA NA NA hsa-miR-654-3p PLK4 -1.77960431554497 1.76486415439529e-14 1.26430111268711 1.52467435090681e-23 miRNATAP -0.129119873594665 6.63810548642167e-08 NA NA NA hsa-miR-155-5p PLS1 0.533437622040649 0.00248671179205372 -1.21263305615705 1.14095019447745e-06 miRNAWalker2_validate -0.20063479326632 0.00121285883569845 NA NA NA hsa-miR-193b-5p PLS1 1.10486595354104 6.41489920661805e-11 -1.21263305615705 1.14095019447745e-06 MirTarget -0.422182855309061 1.55434868946482e-11 NA NA NA hsa-miR-30a-5p PLXNA1 -1.79779915425811 1.93360169837799e-26 1.29616605227792 1.95880306104596e-30 miRNATAP -0.150237053247649 2.5154937898373e-07 NA NA NA hsa-miR-148a-5p PMM1 -1.00478606532747 1.38045244999229e-07 -0.434708142574826 5.23951007062201e-05 MirTarget -0.100144523192662 3.71040147936159e-05 NA NA NA hsa-miR-155-5p PNPLA8 0.533437622040649 0.00248671179205372 -0.329807790166212 0.000476734210469257 miRNAWalker2_validate -0.139813427912293 1.21587999788275e-09 NA NA NA hsa-miR-199a-5p POLR1A -0.364835768178638 0.0435119211101981 0.297575287085005 0.0086722873665153 mirMAP -0.114037891315603 2.80278279215148e-05 NA NA NA hsa-miR-30a-5p POLR3G -1.79779915425811 1.93360169837799e-26 0.299712228314719 0.0736229008082233 miRNATAP -0.218603139635998 7.61668479019839e-08 NA NA NA hsa-miR-199a-5p POU2F1 -0.364835768178638 0.0435119211101981 0.355119362190407 0.00148065238921374 miRanda;mirMAP -0.131673517421952 8.81864398382526e-07 NA NA NA hsa-miR-155-5p PPARA 0.533437622040649 0.00248671179205372 -0.460031262242576 8.07346620234055e-05 mirMAP -0.160837263975027 1.83165825132624e-08 NA NA NA hsa-miR-155-5p PPFIBP1 0.533437622040649 0.00248671179205372 0.306313033295256 0.00838970920986713 miRNAWalker2_validate -0.142465177881326 5.43136878677657e-07 NA NA NA hsa-miR-155-5p PPL 0.533437622040649 0.00248671179205372 -2.24254272707302 8.15395972831989e-19 miRNAWalker2_validate -0.162991164173498 0.0118373415489495 NA NA NA hsa-miR-143-5p PPM1L 0.502923736905281 0.00432190530694735 -2.04355395731861 2.15484178827861e-17 MirTarget -0.16376506486537 0.00770857119596391 NA NA NA hsa-miR-155-5p PPM1L 0.533437622040649 0.00248671179205372 -2.04355395731861 2.15484178827861e-17 mirMAP -0.265531565775534 1.36388832593628e-05 NA NA NA hsa-miR-30a-5p PPP1R14C -1.79779915425811 1.93360169837799e-26 1.14784909213879 9.74125833228602e-08 MirTarget;miRNATAP -0.223018612558786 2.7577680106009e-05 NA NA NA hsa-miR-30a-5p PPP2R5E -1.79779915425811 1.93360169837799e-26 0.180603227918551 0.0767872681161267 mirMAP -0.194859137906426 1.11619503683474e-15 NA NA NA hsa-miR-199a-5p PPP4R2 -0.364835768178638 0.0435119211101981 -0.406065320340848 0.00615969363096744 miRanda -0.108416816246645 0.00244710679581439 NA NA NA hsa-miR-30a-5p PPP4R4 -1.79779915425811 1.93360169837799e-26 2.32661550266457 2.51234196653794e-12 MirTarget;miRNATAP -0.20051222055136 0.0161933640829954 NA NA NA hsa-miR-199a-5p PRC1 -0.364835768178638 0.0435119211101981 1.35374455621743 4.73769657970668e-27 miRanda -0.164062409647424 2.15717042144894e-07 NA NA NA hsa-miR-30a-5p PRDM1 -1.79779915425811 1.93360169837799e-26 -0.687083771174829 6.72611660120109e-05 miRNAWalker2_validate;miRNATAP -0.158585979737839 0.000183592979266268 NA NA NA hsa-miR-148a-5p PRKAB2 -1.00478606532747 1.38045244999229e-07 0.156526190835021 0.192003523440871 mirMAP -0.172164573365488 9.8023897261402e-11 NA NA NA hsa-miR-155-5p PRKAR2A 0.533437622040649 0.00248671179205372 -1.25168983515233 1.27768824698379e-10 miRNAWalker2_validate -0.189259999040221 0.000102344592491054 NA NA NA hsa-miR-30a-5p PRKCDBP -1.79779915425811 1.93360169837799e-26 1.52281244473149 3.46237796481434e-15 miRNAWalker2_validate -0.10857905975304 0.0261973263043005 NA NA NA hsa-miR-155-5p PRKCI 0.533437622040649 0.00248671179205372 0.292711236284172 0.00258969610346621 miRNAWalker2_validate -0.105374421006605 9.85855202028185e-06 NA NA NA hsa-miR-155-5p PRKG1 0.533437622040649 0.00248671179205372 -0.538721983685554 0.0802263983076592 miRNATAP -0.389836629202279 2.24550490455329e-07 NA NA NA hsa-miR-155-5p PROX1 0.533437622040649 0.00248671179205372 -0.517410950400472 0.0779956935501051 miRNATAP -0.225819578788192 0.00180422736449329 NA NA NA hsa-miR-30a-5p PRPF40A -1.79779915425811 1.93360169837799e-26 0.212707892265978 0.000752194390409795 miRNAWalker2_validate -0.102885834052059 1.14733459225414e-11 NA NA NA hsa-miR-199a-5p PRPS2 -0.364835768178638 0.0435119211101981 0.223077777164124 0.0239958195424205 miRanda -0.127127521108972 6.84990920319333e-08 NA NA NA hsa-miR-155-5p PSKH1 0.533437622040649 0.00248671179205372 -0.244588792135264 0.00410229720338886 MirTarget;miRNATAP -0.120701580178145 5.88360132744606e-09 NA NA NA hsa-miR-30a-5p PSME3 -1.79779915425811 1.93360169837799e-26 0.203877688942444 0.00114367590202639 miRNATAP -0.127661476515459 8.26542350309987e-18 NA NA NA hsa-miR-30a-5p PTBP1 -1.79779915425811 1.93360169837799e-26 0.347284533140036 2.17995860174657e-10 miRNAWalker2_validate -0.107324185756844 3.5559966366106e-16 NA NA NA hsa-miR-155-5p PTCHD1 0.533437622040649 0.00248671179205372 -1.28800309042862 0.00016650440693923 mirMAP -0.369493233661181 1.19635431397558e-05 NA NA NA hsa-miR-193b-5p PTCHD1 1.10486595354104 6.41489920661805e-11 -1.28800309042862 0.00016650440693923 mirMAP -0.685360253507017 6.26107140613023e-16 NA NA NA hsa-miR-30a-5p PTGFRN -1.79779915425811 1.93360169837799e-26 1.11896906438663 8.38020160661863e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.295391078178067 2.26480538205871e-19 NA NA NA hsa-miR-30a-5p PTPRD -1.79779915425811 1.93360169837799e-26 0.347580650962575 0.338899666997425 mirMAP -0.320175434818125 0.000314427162049129 NA NA NA hsa-miR-199a-5p PTPRF -0.364835768178638 0.0435119211101981 0.0742178360864347 0.506688525125653 miRanda -0.101598405296664 0.000149635595521549 NA NA NA hsa-miR-155-5p PTPRG 0.533437622040649 0.00248671179205372 0.19176862613844 0.327187865640097 mirMAP -0.199761438119337 3.1572745136554e-05 NA NA NA hsa-miR-30a-5p PTPRK -1.79779915425811 1.93360169837799e-26 0.85295530565792 7.40632367723054e-13 miRNAWalker2_validate -0.142386128733854 1.48980967740213e-06 NA NA NA hsa-miR-155-5p PTPRQ 0.533437622040649 0.00248671179205372 -0.914607816663381 0.00813976045462068 MirTarget -0.19817229949171 0.0205141915789178 NA NA NA hsa-miR-155-5p PYGL 0.533437622040649 0.00248671179205372 0.924804196382585 1.37062197635314e-05 miRNAWalker2_validate -0.239880846002437 4.93834734368273e-06 NA NA NA hsa-miR-199a-5p PYGL -0.364835768178638 0.0435119211101981 0.924804196382585 1.37062197635314e-05 miRanda -0.114587785726518 0.0268266035167922 NA NA NA hsa-miR-193b-5p QRFPR 1.10486595354104 6.41489920661805e-11 0.349082770362699 0.531176036474013 MirTarget -0.561071976478317 6.52407066008663e-05 NA NA NA hsa-miR-145-5p QSER1 -0.46917511594055 0.000685297625493134 0.126858361672976 0.219534591864585 miRNATAP -0.105072860056069 0.00119733339698634 NA NA NA hsa-miR-199a-5p RAB10 -0.364835768178638 0.0435119211101981 -0.568925096662655 1.24859115515124e-07 PITA;miRanda;miRNATAP -0.101542695270716 0.000101737603955198 NA NA NA hsa-miR-30a-5p RAB10 -1.79779915425811 1.93360169837799e-26 -0.568925096662655 1.24859115515124e-07 MirTarget;miRNATAP -0.13159602195102 6.48259952646953e-07 NA NA NA hsa-miR-199a-5p RAB11FIP1 -0.364835768178638 0.0435119211101981 -1.51128630431987 1.15788997201658e-14 miRanda -0.166462874369114 0.000582373174593943 NA NA NA hsa-miR-155-5p RAB22A 0.533437622040649 0.00248671179205372 0.262514909421122 0.00418786072049303 mirMAP -0.110624037199785 8.07547119047686e-07 NA NA NA hsa-miR-30a-5p RAB22A -1.79779915425811 1.93360169837799e-26 0.262514909421122 0.00418786072049303 miRNATAP -0.153576069628717 3.233593326752e-12 NA NA NA hsa-miR-155-5p RAB2A 0.533437622040649 0.00248671179205372 -0.0176792943011623 0.81532235516446 miRNAWalker2_validate -0.113871508557625 4.75046865509292e-10 NA NA NA hsa-miR-155-5p RAB30 0.533437622040649 0.00248671179205372 -0.282525876657138 0.0615843179007187 miRNAWalker2_validate;mirMAP -0.128166300072761 0.000567971565035772 NA NA NA hsa-miR-30a-5p RAB32 -1.79779915425811 1.93360169837799e-26 1.18224326844676 1.54121566055888e-16 MirTarget;miRNATAP -0.123635270021195 0.00062242390794896 NA NA NA hsa-miR-30a-5p RAB38 -1.79779915425811 1.93360169837799e-26 0.508386224585545 0.0355305183309136 miRNATAP -0.352761130620956 1.6970342308169e-09 NA NA NA hsa-miR-30a-5p RAB3B -1.79779915425811 1.93360169837799e-26 2.10652499120069 8.85644562497935e-08 mirMAP -0.322681286950149 0.000953369658702363 NA NA NA hsa-miR-155-5p RAB6A 0.533437622040649 0.00248671179205372 -0.254829367736762 0.0109191681267139 miRNAWalker2_validate;miRNATAP -0.132354284271351 5.99429292131089e-08 NA NA NA hsa-miR-155-5p RAB6C 0.533437622040649 0.00248671179205372 -0.262409934133329 0.0408332925562986 miRNAWalker2_validate -0.109530890030764 0.000519553249573584 NA NA NA hsa-miR-30a-5p RAB8A -1.79779915425811 1.93360169837799e-26 0.326124459525518 4.46224081845825e-08 MirTarget -0.107525350591996 7.09137429762084e-14 NA NA NA hsa-miR-125a-5p RACGAP1 0.215366061934933 0.119550904549401 1.14636631422181 4.36852962062961e-27 miRanda -0.14036312814635 6.88336512479834e-05 NA NA NA hsa-miR-139-5p RACGAP1 -1.46099200329485 7.85040381494472e-22 1.14636631422181 4.36852962062961e-27 miRanda -0.161501801508969 1.21430538604244e-07 NA NA NA hsa-miR-199a-5p RAD21 -0.364835768178638 0.0435119211101981 0.645202641172029 1.80982529755565e-14 miRanda -0.112137380703865 4.94729653936104e-08 NA NA NA hsa-miR-199a-5p RAET1E -0.364835768178638 0.0435119211101981 -1.74866216916985 1.24719480360585e-06 miRanda -0.196594351618512 0.0254866299803778 NA NA NA hsa-miR-148a-5p RAP2B -1.00478606532747 1.38045244999229e-07 0.557861146815088 4.82369176844608e-06 mirMAP -0.119763390938221 1.442928316303e-05 NA NA NA hsa-miR-30a-5p RAP2B -1.79779915425811 1.93360169837799e-26 0.557861146815088 4.82369176844608e-06 mirMAP -0.289749431887359 9.66011090584423e-24 NA NA NA hsa-miR-30a-5p RAP2C -1.79779915425811 1.93360169837799e-26 0.169196041777012 0.0371802139373293 MirTarget;miRNATAP -0.120018711157283 8.63822172384954e-10 NA NA NA hsa-miR-155-5p RAPGEF4 0.533437622040649 0.00248671179205372 0.138671549456375 0.391567909378863 miRNATAP -0.182658164163761 3.97515698884524e-06 NA NA NA hsa-miR-30a-5p RAPGEF6 -1.79779915425811 1.93360169837799e-26 -0.477349657000632 0.0322274812403676 mirMAP -0.108045152124266 0.0486939521337607 NA NA NA hsa-miR-30a-5p RARG -1.79779915425811 1.93360169837799e-26 -0.309340688602448 0.00754844806427886 MirTarget;miRNATAP -0.11404204656689 5.56283579444064e-05 NA NA NA hsa-miR-30a-5p RASA2 -1.79779915425811 1.93360169837799e-26 -0.13563780086651 0.471912272909971 mirMAP -0.170238889323838 0.00021815984118059 NA NA NA hsa-miR-155-5p RASAL2 0.533437622040649 0.00248671179205372 -0.623106165029537 1.69413875486803e-06 MirTarget -0.167809863270317 1.67687241030946e-07 NA NA NA hsa-miR-199a-5p RASSF3 -0.364835768178638 0.0435119211101981 -0.392418111097313 0.0655571603941586 miRNATAP -0.179293942765107 0.000473933665530861 NA NA NA hsa-miR-199a-5p RB1 -0.364835768178638 0.0435119211101981 -0.0268480421254154 0.835486401596562 miRanda -0.152257242544093 8.05128748947185e-07 NA NA NA hsa-miR-30a-5p RBAK -1.79779915425811 1.93360169837799e-26 0.282157001981175 0.00106645504310766 mirMAP -0.118184566294592 1.59061932839729e-08 NA NA NA hsa-miR-199a-5p RBL1 -0.364835768178638 0.0435119211101981 0.661862629855869 2.83210541337127e-05 miRanda -0.192350802150513 4.30235952663098e-07 NA NA NA hsa-miR-148a-5p RBM24 -1.00478606532747 1.38045244999229e-07 -2.21652130179077 1.42262329319543e-07 MirTarget -0.26024592874282 0.0069017316845478 NA NA NA hsa-miR-199a-5p RBM47 -0.364835768178638 0.0435119211101981 -1.50298120109863 6.01039102199017e-24 miRanda;miRNATAP -0.237038975698105 1.51670641057226e-10 NA NA NA hsa-miR-30a-5p RC3H2 -1.79779915425811 1.93360169837799e-26 0.122703007468027 0.369873012824564 mirMAP -0.172208916510865 2.11516738972911e-07 NA NA NA hsa-miR-155-5p RCN2 0.533437622040649 0.00248671179205372 0.309024280017656 0.00126064831110211 miRNAWalker2_validate;MirTarget -0.126307195700777 6.90814873791635e-08 NA NA NA hsa-miR-145-5p RCOR1 -0.46917511594055 0.000685297625493134 -0.0359222260103218 0.767701295231638 miRNATAP -0.12585312134589 0.000977209888211616 NA NA NA hsa-miR-155-5p RCOR1 0.533437622040649 0.00248671179205372 -0.0359222260103218 0.767701295231638 miRNAWalker2_validate;miRNATAP -0.162880540061618 3.7075631865165e-08 NA NA NA hsa-miR-30a-5p RCOR1 -1.79779915425811 1.93360169837799e-26 -0.0359222260103218 0.767701295231638 mirMAP;miRNATAP -0.2374346123493 2.18255956036738e-16 NA NA NA hsa-miR-30a-5p REEP3 -1.79779915425811 1.93360169837799e-26 0.165908749214797 0.152487167913315 MirTarget;miRNATAP -0.157896726968511 1.83137561940249e-08 NA NA NA hsa-miR-193b-5p REPIN1 1.10486595354104 6.41489920661805e-11 -0.893084586412232 2.64720252410999e-09 mirMAP -0.467819699468946 3.61735012679578e-39 NA NA NA hsa-miR-199a-5p RFC1 -0.364835768178638 0.0435119211101981 0.216824337384912 0.00425299232840281 miRanda -0.108846064548715 1.5033343756518e-09 NA NA NA hsa-miR-199a-5p RFX3 -0.364835768178638 0.0435119211101981 -0.157051400074304 0.371649390702098 miRanda -0.167037950361123 7.49833055072994e-05 NA NA NA hsa-miR-199a-5p RGP1 -0.364835768178638 0.0435119211101981 -0.369842274777049 0.0603469454793966 mirMAP -0.153398389477752 0.00122214924927037 NA NA NA hsa-miR-199a-5p RHEBL1 -0.364835768178638 0.0435119211101981 2.0677107792456 3.37989802602691e-29 miRanda -0.109120616404002 0.0206189282349725 NA NA NA hsa-miR-30a-5p RHOF -1.79779915425811 1.93360169837799e-26 0.951347457971131 1.19652126366099e-05 miRNAWalker2_validate -0.189572657110812 0.000403064177066708 NA NA NA hsa-miR-199a-5p RIF1 -0.364835768178638 0.0435119211101981 0.208013415969114 0.172630733750787 miRanda -0.133355252542638 0.000274000504742561 NA NA NA hsa-miR-30a-5p RIMBP2 -1.79779915425811 1.93360169837799e-26 -0.154572721153582 0.60820557889701 MirTarget;miRNATAP -0.218358021782769 0.00310465564354327 NA NA NA hsa-miR-199a-5p RND1 -0.364835768178638 0.0435119211101981 -1.44180509646861 7.84326316485061e-10 PITA;miRanda;miRNATAP -0.135077334147853 0.0189673219801645 NA NA NA hsa-miR-148a-5p RND3 -1.00478606532747 1.38045244999229e-07 -0.579595447029784 0.000104597977093238 miRNATAP -0.118565926374537 0.000459450038935271 NA NA NA hsa-miR-145-5p RNF169 -0.46917511594055 0.000685297625493134 -0.486970934093665 0.00304821287977203 mirMAP -0.104163756274502 0.0452493594380365 NA NA NA hsa-miR-155-5p RNF2 0.533437622040649 0.00248671179205372 0.472811299016671 1.78030083065978e-10 miRNAWalker2_validate -0.10095637851262 3.61708322197329e-08 NA NA NA hsa-miR-30a-5p RNF217 -1.79779915425811 1.93360169837799e-26 0.599106862069542 0.000118589900561354 mirMAP -0.29194523187371 6.02414849513419e-15 NA NA NA hsa-miR-155-5p RORA 0.533437622040649 0.00248671179205372 -1.34190016725494 2.93933073675312e-14 MirTarget;mirMAP;miRNATAP -0.211337651515143 1.89107589992733e-06 NA NA NA hsa-miR-148a-5p RPL37 -1.00478606532747 1.38045244999229e-07 0.00410033886374528 0.973613249864401 mirMAP -0.153538095328709 2.71112834304194e-08 NA NA NA hsa-miR-30a-5p RPP40 -1.79779915425811 1.93360169837799e-26 0.268671100517454 0.0112952339848502 miRNAWalker2_validate -0.104555971630926 5.39456415171569e-05 NA NA NA hsa-miR-199a-5p RPS6KA5 -0.364835768178638 0.0435119211101981 -0.635689995193579 3.47825449174147e-05 miRanda -0.142362044175349 0.000126676245851765 NA NA NA hsa-miR-30a-5p RRAS2 -1.79779915425811 1.93360169837799e-26 0.702932455850408 1.99932755914681e-08 miRNATAP -0.120338084173712 0.000103191367577221 NA NA NA hsa-miR-145-5p RREB1 -0.46917511594055 0.000685297625493134 -0.689342017504029 9.2948055090823e-06 miRNATAP -0.118695140296902 0.0163292847377933 NA NA NA hsa-miR-155-5p RREB1 0.533437622040649 0.00248671179205372 -0.689342017504029 9.2948055090823e-06 miRNAWalker2_validate;miRNATAP -0.116478061215 0.00255524842289352 NA NA NA hsa-miR-199a-5p RRM2 -0.364835768178638 0.0435119211101981 1.43072923436349 4.76347605113061e-23 miRanda -0.202244030529267 2.04040786612199e-08 NA NA NA hsa-miR-30a-5p RRM2 -1.79779915425811 1.93360169837799e-26 1.43072923436349 4.76347605113061e-23 miRNAWalker2_validate -0.289076549761803 1.18014872954407e-15 NA NA NA hsa-miR-148a-5p RRP8 -1.00478606532747 1.38045244999229e-07 0.123336113189949 0.126404351822939 mirMAP -0.123533733994979 3.9854376515756e-12 NA NA NA hsa-miR-199a-5p RTKN2 -0.364835768178638 0.0435119211101981 -0.251166409081334 0.262848253539071 miRanda -0.117379230507082 0.0301573393711568 NA NA NA hsa-miR-199a-5p RTP4 -0.364835768178638 0.0435119211101981 1.36149886234183 4.90372943667252e-09 miRanda -0.159973891535711 0.00498532698759987 NA NA NA hsa-miR-30a-5p S100A7A -1.79779915425811 1.93360169837799e-26 1.75305475063072 0.00299280817721015 mirMAP -1.00440741710024 1.77478611055743e-12 NA NA NA hsa-miR-155-5p SALL1 0.533437622040649 0.00248671179205372 1.1695953502832 0.0016002955394505 miRNATAP -0.63572898738412 1.55446469737477e-12 NA NA NA hsa-miR-30a-5p SAMD8 -1.79779915425811 1.93360169837799e-26 -0.246666183887303 0.0501700188207481 MirTarget;miRNATAP -0.139332931565726 5.5613771597138e-06 NA NA NA hsa-miR-30a-5p SAMD9 -1.79779915425811 1.93360169837799e-26 0.594941542746321 0.0160334463018318 miRNAWalker2_validate -0.417382403833596 2.29476380648544e-12 NA NA NA hsa-miR-30a-5p SATB2 -1.79779915425811 1.93360169837799e-26 0.534633356380015 0.00086445455800548 miRNATAP -0.127139791139433 0.00126665286588456 NA NA NA hsa-miR-193b-5p SBK1 1.10486595354104 6.41489920661805e-11 -1.31664164467748 1.37623902403365e-05 mirMAP -0.803872616248335 5.69515138315821e-28 NA NA NA hsa-miR-155-5p SBNO1 0.533437622040649 0.00248671179205372 -0.22989049386433 0.260399659796918 mirMAP -0.194478727222289 0.000105637558856286 NA NA NA hsa-miR-30a-5p SBNO1 -1.79779915425811 1.93360169837799e-26 -0.22989049386433 0.260399659796918 miRNATAP -0.174164786906773 0.00048832540151847 NA NA NA hsa-miR-155-5p SCAMP1 0.533437622040649 0.00248671179205372 -0.114068429639469 0.193901904166203 miRNAWalker2_validate -0.102888419336675 1.55312721428596e-06 NA NA NA hsa-miR-30a-5p SCD -1.79779915425811 1.93360169837799e-26 0.697372495689478 0.00020237587411881 miRNAWalker2_validate -0.335230394516884 1.24577409475153e-13 NA NA NA hsa-miR-155-5p SCG2 0.533437622040649 0.00248671179205372 0.547136505940647 0.0678591849740243 MirTarget;miRNATAP -0.34047767834695 3.56513042027593e-06 NA NA NA hsa-miR-30a-5p SCN8A -1.79779915425811 1.93360169837799e-26 1.50094782259257 5.81630428809064e-08 MirTarget -0.278636975220923 4.68496357000397e-05 NA NA NA hsa-miR-155-5p SCN9A 0.533437622040649 0.00248671179205372 0.172029019527262 0.66919871072311 mirMAP -0.414741307574737 2.66984882479976e-05 NA NA NA hsa-miR-199a-5p SCNN1G -0.364835768178638 0.0435119211101981 -1.90530729378342 6.48280261332157e-08 miRanda -0.301490231150243 0.000451004848197846 NA NA NA hsa-miR-193b-5p SCYL3 1.10486595354104 6.41489920661805e-11 -0.35583810847439 3.85103343251295e-06 MirTarget -0.167142124428296 1.17761980532625e-18 NA NA NA hsa-miR-199a-5p SDR42E1 -0.364835768178638 0.0435119211101981 -0.105551906075223 0.66899436319087 miRanda -0.155975629559827 0.00875859679519582 NA NA NA hsa-miR-30a-5p SEC23A -1.79779915425811 1.93360169837799e-26 0.437445872055685 0.000210104709075603 miRNAWalker2_validate;MirTarget;miRNATAP -0.169835592932434 3.16510407781451e-09 NA NA NA hsa-miR-199a-5p SEC24A -0.364835768178638 0.0435119211101981 -0.236557225255523 0.0268179028436571 miRanda -0.10075884445401 8.54843672825735e-05 NA NA NA hsa-miR-30a-5p SEC24A -1.79779915425811 1.93360169837799e-26 -0.236557225255523 0.0268179028436571 miRNAWalker2_validate;MirTarget;miRNATAP -0.107795597139968 3.5236876070257e-05 NA NA NA hsa-miR-155-5p SEMA5A 0.533437622040649 0.00248671179205372 -1.02635761461988 1.79216109198623e-05 miRNATAP -0.152177213417675 0.0105276380793814 NA NA NA hsa-miR-30a-5p SENP5 -1.79779915425811 1.93360169837799e-26 0.761805479049603 1.48528153976512e-19 mirMAP -0.147774829455217 1.71744073724857e-12 NA NA NA hsa-miR-199a-5p SERPINB5 -0.364835768178638 0.0435119211101981 0.195467092677395 0.374442931189982 miRanda -0.126387843553672 0.0172607139083172 NA NA NA hsa-miR-30a-5p SERPINB5 -1.79779915425811 1.93360169837799e-26 0.195467092677395 0.374442931189982 miRNAWalker2_validate -0.394271321582041 7.33480296016729e-14 NA NA NA hsa-miR-199a-5p SERPINB7 -0.364835768178638 0.0435119211101981 0.923324670845465 0.0104032660846092 miRanda -0.274913240844714 0.00158025833703497 NA NA NA hsa-miR-199a-5p SERPINB8 -0.364835768178638 0.0435119211101981 -0.325373897251245 0.0178721219452133 miRanda -0.131682959178805 6.66323040696038e-05 NA NA NA hsa-miR-148a-5p SERPINE1 -1.00478606532747 1.38045244999229e-07 2.9800460155055 1.19587534601183e-23 miRNATAP -0.483536967493396 2.33591419513461e-12 NA NA NA hsa-miR-30a-5p SERPINE1 -1.79779915425811 1.93360169837799e-26 2.9800460155055 1.19587534601183e-23 miRNATAP -0.538352757158472 6.00868327349311e-13 NA NA NA hsa-miR-155-5p SERTAD2 0.533437622040649 0.00248671179205372 0.0314397698109881 0.764141426268602 miRNAWalker2_validate;miRNATAP -0.117527172738313 4.37895037498392e-06 NA NA NA hsa-miR-155-5p SERTAD4 0.533437622040649 0.00248671179205372 -1.20714475309274 2.27886561126817e-06 mirMAP -0.265257159987882 2.76769490222023e-05 NA NA NA hsa-miR-199a-5p SFXN1 -0.364835768178638 0.0435119211101981 0.572838887040866 3.66133606837167e-10 miRanda -0.113221075353951 3.27340196562513e-07 NA NA NA hsa-miR-148a-5p SGIP1 -1.00478606532747 1.38045244999229e-07 1.79994677668641 1.17270238530843e-16 MirTarget -0.187223413101888 0.000207609958535834 NA NA NA hsa-miR-30a-5p SGIP1 -1.79779915425811 1.93360169837799e-26 1.79994677668641 1.17270238530843e-16 mirMAP -0.192032193094582 0.000461976722479611 NA NA NA hsa-miR-145-5p SH3BP1 -0.46917511594055 0.000685297625493134 0.618557384389019 1.67591299823945e-08 MirTarget -0.120911955894667 0.000531096999111259 NA NA NA hsa-miR-155-5p SH3BP4 0.533437622040649 0.00248671179205372 0.271690171498704 0.0181344213406129 miRNAWalker2_validate -0.118939269378518 2.49035004419599e-05 NA NA NA hsa-miR-199a-5p SH3RF2 -0.364835768178638 0.0435119211101981 -0.48376225718998 0.00180955177463794 miRanda -0.126627248078665 0.000717405982425579 NA NA NA hsa-miR-199a-5p SH3TC2 -0.364835768178638 0.0435119211101981 -0.81727628712102 0.000830009467360778 PITA -0.167526136127576 0.0046604767642514 NA NA NA hsa-miR-193b-5p SHISA9 1.10486595354104 6.41489920661805e-11 -2.91090822441451 1.34309883098173e-17 mirMAP -0.649965589759205 9.34858811561641e-14 NA NA NA hsa-miR-30a-5p SIAH2 -1.79779915425811 1.93360169837799e-26 0.463927352852682 3.58182093123053e-05 miRNATAP -0.178011082180531 6.07878444725679e-11 NA NA NA hsa-miR-30a-5p SKIL -1.79779915425811 1.93360169837799e-26 0.74632148938579 3.58973925573533e-06 miRNATAP -0.259783180035989 3.22455022801906e-11 NA NA NA hsa-miR-30a-5p SKP2 -1.79779915425811 1.93360169837799e-26 0.847981453329814 1.12276777710769e-09 MirTarget;miRNATAP -0.182102888515017 1.13631104169536e-07 NA NA NA hsa-miR-199a-5p SLAMF1 -0.364835768178638 0.0435119211101981 0.211249633406686 0.381463732891631 miRanda -0.115974224512708 0.0465548331137832 NA NA NA hsa-miR-30a-5p SLC12A6 -1.79779915425811 1.93360169837799e-26 -0.345267539375285 0.0339248327054542 MirTarget -0.11465965735654 0.00407936033658383 NA NA NA hsa-miR-155-5p SLC13A3 0.533437622040649 0.00248671179205372 -0.960677411964701 4.21778668236745e-05 mirMAP -0.148472058981327 0.0108454611672184 NA NA NA hsa-miR-193b-5p SLC14A1 1.10486595354104 6.41489920661805e-11 -1.88830962432723 5.86978742826034e-13 MirTarget -0.514433573689227 8.39359880874846e-15 NA NA NA hsa-miR-199a-5p SLC16A1 -0.364835768178638 0.0435119211101981 1.48310636341506 2.23852777832001e-20 miRanda -0.178172827752671 8.21859237473761e-06 NA NA NA hsa-miR-155-5p SLC20A2 0.533437622040649 0.00248671179205372 -0.28665241828369 0.0341847763775691 miRNATAP -0.177145352324799 8.25566350539844e-08 NA NA NA hsa-miR-148a-5p SLC22A15 -1.00478606532747 1.38045244999229e-07 -0.107696671932468 0.540516921632165 MirTarget -0.205384411157053 1.75328404394632e-07 NA NA NA hsa-miR-199a-5p SLC26A4 -0.364835768178638 0.0435119211101981 -1.6361495074291 9.84822878880965e-10 miRanda -0.23292834043629 0.00037562652964741 NA NA NA hsa-miR-30a-5p SLC28A3 -1.79779915425811 1.93360169837799e-26 0.913793405775946 0.00570401860464323 mirMAP -0.439741047561574 4.56223848192549e-08 NA NA NA hsa-miR-199a-5p SLC2A1 -0.364835768178638 0.0435119211101981 1.86992096220661 7.7016211797623e-21 miRNATAP -0.167587985375337 0.000810639392014282 NA NA NA hsa-miR-155-5p SLC30A4 0.533437622040649 0.00248671179205372 -0.398278282768212 0.0379930412545886 mirMAP -0.241319139598656 2.73677092930867e-07 NA NA NA hsa-miR-30a-5p SLC30A4 -1.79779915425811 1.93360169837799e-26 -0.398278282768212 0.0379930412545886 mirMAP -0.221348213883009 2.2141319625664e-06 NA NA NA hsa-miR-155-5p SLC33A1 0.533437622040649 0.00248671179205372 0.430512033355744 9.9249523160388e-06 miRNAWalker2_validate -0.125803092044789 1.46721361173607e-07 NA NA NA hsa-miR-199a-5p SLC35A3 -0.364835768178638 0.0435119211101981 -0.51719216195548 9.57580223914983e-06 MirTarget -0.153851490631356 4.19432001466164e-08 NA NA NA hsa-miR-155-5p SLC35F2 0.533437622040649 0.00248671179205372 -0.12003012255394 0.417783045871596 miRNAWalker2_validate -0.116987944312008 0.00131882884894989 NA NA NA hsa-miR-155-5p SLC35F5 0.533437622040649 0.00248671179205372 -0.420945126768846 0.000122038422437445 MirTarget -0.214839930320344 3.85513483103778e-16 NA NA NA hsa-miR-30a-5p SLC36A1 -1.79779915425811 1.93360169837799e-26 0.752687735688592 2.51282954597007e-13 miRNATAP -0.183991523331309 3.05988105343321e-13 NA NA NA hsa-miR-199a-5p SLC38A1 -0.364835768178638 0.0435119211101981 0.237439020504589 0.0296478053057796 miRanda -0.16559607321561 1.60844678302911e-10 NA NA NA hsa-miR-30a-5p SLC38A1 -1.79779915425811 1.93360169837799e-26 0.237439020504589 0.0296478053057796 miRNAWalker2_validate -0.129593555351469 1.04995581569314e-06 NA NA NA hsa-miR-30a-5p SLC38A2 -1.79779915425811 1.93360169837799e-26 0.348312989295044 0.00641051803471899 miRNAWalker2_validate;mirMAP;miRNATAP -0.221961199256709 4.92126592868406e-13 NA NA NA hsa-miR-30a-5p SLC38A5 -1.79779915425811 1.93360169837799e-26 1.01925034822305 0.000730637814685201 miRNAWalker2_validate -0.265100513508533 0.000349662077074848 NA NA NA hsa-miR-30a-5p SLC38A7 -1.79779915425811 1.93360169837799e-26 0.72789172373579 1.42994397017137e-06 MirTarget;miRNATAP -0.290781476532291 1.3275475777731e-15 NA NA NA hsa-miR-155-5p SLC39A10 0.533437622040649 0.00248671179205372 0.609117373837615 4.11600070313958e-07 miRNAWalker2_validate;miRNATAP -0.121606570087283 4.5491373387939e-05 NA NA NA hsa-miR-155-5p SLC39A14 0.533437622040649 0.00248671179205372 0.884594754669005 1.74879712773002e-08 miRNAWalker2_validate -0.156814587258797 5.98082159171016e-05 NA NA NA hsa-miR-148a-5p SLC5A12 -1.00478606532747 1.38045244999229e-07 3.08385019976726 4.07270344709609e-14 mirMAP -0.200235410670611 0.0345550697937812 NA NA NA hsa-miR-30a-5p SLC5A3 -1.79779915425811 1.93360169837799e-26 0.658754063645429 1.47482248707421e-07 miRNATAP -0.151964473676063 8.19443259135096e-07 NA NA NA hsa-miR-30a-5p SLC6A15 -1.79779915425811 1.93360169837799e-26 0.414107427666912 0.291006117055702 mirMAP -0.322051734852628 0.000792099945139926 NA NA NA hsa-miR-30a-5p SLC6A9 -1.79779915425811 1.93360169837799e-26 0.136651558117268 0.351932000382009 MirTarget;miRNATAP -0.114244794725291 0.00146094447651098 NA NA NA hsa-miR-148a-5p SLC7A11 -1.00478606532747 1.38045244999229e-07 1.0995991567892 0.000784097094192086 mirMAP -0.206304999088023 0.00547919202392191 NA NA NA hsa-miR-155-5p SLC7A11 0.533437622040649 0.00248671179205372 1.0995991567892 0.000784097094192086 miRNAWalker2_validate;mirMAP -0.527492826194736 3.67839169862955e-11 NA NA NA hsa-miR-30a-5p SLC7A11 -1.79779915425811 1.93360169837799e-26 1.0995991567892 0.000784097094192086 miRNAWalker2_validate;mirMAP;miRNATAP -0.652297935245612 8.23660988902256e-17 NA NA NA hsa-miR-199a-5p SLC7A5 -0.364835768178638 0.0435119211101981 1.25659623560685 7.43593516692192e-10 MirTarget -0.148501154685015 0.00299154660482637 NA NA NA hsa-miR-30a-5p SLC7A5 -1.79779915425811 1.93360169837799e-26 1.25659623560685 7.43593516692192e-10 MirTarget -0.480269812532232 7.40130843366619e-23 NA NA NA hsa-miR-155-5p SLCO1A2 0.533437622040649 0.00248671179205372 1.73886716171295 0.00101431111192431 mirMAP -0.553235782978766 2.21142650499807e-05 NA NA NA hsa-miR-145-5p SMAD3 -0.46917511594055 0.000685297625493134 -0.143490080047147 0.241618109620266 MirTarget;miRNATAP -0.115484614688291 0.00271929213208624 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 0.533437622040649 0.00248671179205372 -0.143490080047147 0.241618109620266 miRNAWalker2_validate -0.125492484204873 2.91075561128582e-05 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-155-5p SMAD9 0.533437622040649 0.00248671179205372 -1.69273383120059 1.99204561614593e-09 mirMAP -0.322056804045091 4.58032969731507e-06 NA NA NA hsa-miR-145-5p SMC1A -0.46917511594055 0.000685297625493134 0.238379624133141 0.020553539443373 mirMAP -0.128144202391056 7.21953734027403e-05 NA NA NA hsa-miR-199a-5p SMC4 -0.364835768178638 0.0435119211101981 1.16561320133234 1.00447993190385e-19 miRanda -0.15281141727543 1.60344113991513e-06 NA NA NA hsa-miR-30a-5p SNX33 -1.79779915425811 1.93360169837799e-26 -0.229569308981703 0.0408414920301207 MirTarget -0.125353849305538 4.48422911135838e-06 NA NA NA hsa-miR-193b-5p SORCS1 1.10486595354104 6.41489920661805e-11 -3.36537020224739 8.28547282584161e-24 MirTarget -0.406017601030412 4.13242625478668e-06 NA NA NA hsa-miR-155-5p SORL1 0.533437622040649 0.00248671179205372 0.417273256284203 0.0439204734047492 miRNATAP -0.199002112886044 9.29358173812699e-05 NA NA NA hsa-miR-155-5p SORT1 0.533437622040649 0.00248671179205372 -1.64893901531564 1.23680158236484e-23 MirTarget -0.194382327167182 4.09358348931066e-06 NA NA NA hsa-miR-155-5p SOX11 0.533437622040649 0.00248671179205372 3.39585978538847 1.89678346343057e-24 miRNATAP -0.435428446831799 3.36836643785979e-07 NA NA NA hsa-miR-30a-5p SOX11 -1.79779915425811 1.93360169837799e-26 3.39585978538847 1.89678346343057e-24 mirMAP -0.317091170100895 0.000203709109955621 NA NA NA hsa-miR-30a-5p SOX12 -1.79779915425811 1.93360169837799e-26 1.28867093303611 4.0466261043165e-20 miRNATAP -0.170450037172665 1.53190589465156e-06 NA NA NA hsa-miR-155-5p SPIRE1 0.533437622040649 0.00248671179205372 0.271826284040471 0.054263156942915 mirMAP -0.105187900501762 0.0024993794322291 NA NA NA hsa-miR-148a-5p SPOCK1 -1.00478606532747 1.38045244999229e-07 0.909471276801658 0.00559136709150591 mirMAP -0.251126910829556 0.000713466577363547 NA NA NA hsa-miR-148a-5p SPRY4 -1.00478606532747 1.38045244999229e-07 1.65093100608809 3.59794139825157e-25 mirMAP -0.133790708411739 0.000384626032445054 NA NA NA hsa-miR-145-5p SPTLC2 -0.46917511594055 0.000685297625493134 -0.377940852763626 0.000554234698774952 MirTarget -0.105578714381396 0.00225043420859615 NA NA NA hsa-miR-30a-5p SPTLC2 -1.79779915425811 1.93360169837799e-26 -0.377940852763626 0.000554234698774952 mirMAP -0.105867732200735 7.84444975713779e-05 NA NA NA hsa-miR-199a-5p SRGAP3 -0.364835768178638 0.0435119211101981 -0.441408966912155 0.00703272361834523 miRanda -0.106900839602974 0.00690374321666464 NA NA NA hsa-miR-148a-5p SRI -1.00478606532747 1.38045244999229e-07 0.0214960146888679 0.812846265878943 MirTarget -0.103260534051146 3.3769565044798e-07 NA NA NA hsa-miR-155-5p SRPK2 0.533437622040649 0.00248671179205372 0.568003087236783 3.12480490985209e-07 miRNAWalker2_validate -0.17572946723614 1.03710363730349e-10 NA NA NA hsa-miR-193b-5p SSBP2 1.10486595354104 6.41489920661805e-11 -1.19332192067959 8.50582266405563e-15 mirMAP -0.346216704064996 3.24864214424801e-19 NA NA NA hsa-miR-145-5p STAT1 -0.46917511594055 0.000685297625493134 1.29636069409508 5.42773871497242e-12 miRNAWalker2_validate;miRTarBase -0.321524015834427 8.06935548764194e-08 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-miR-139-5p STIL -1.46099200329485 7.85040381494472e-22 1.34487903302373 4.87571470779946e-22 miRanda -0.247303925704699 3.42386291854696e-10 NA NA NA hsa-miR-199a-5p STIL -0.364835768178638 0.0435119211101981 1.34487903302373 4.87571470779946e-22 miRanda -0.257546723857643 5.37730599041114e-14 NA NA NA hsa-miR-199b-5p STIL -1.08432682485992 7.68241801134089e-10 1.34487903302373 4.87571470779946e-22 miRanda -0.297494356438086 3.71629511729568e-18 NA NA NA hsa-miR-26b-5p STIL -0.254478038884324 0.0285227763044636 1.34487903302373 4.87571470779946e-22 miRNAWalker2_validate -0.131792913596617 0.0162456839207115 NA NA NA hsa-miR-148a-5p STK17A -1.00478606532747 1.38045244999229e-07 0.878065257578315 2.22546032096727e-11 MirTarget -0.206408705666811 3.24354027844453e-12 NA NA NA hsa-miR-30a-5p STK35 -1.79779915425811 1.93360169837799e-26 0.247710524651345 0.00737356808706193 MirTarget;miRNATAP -0.153903529638175 4.37538169440809e-12 NA NA NA hsa-miR-199a-5p STK4 -0.364835768178638 0.0435119211101981 0.441383320872455 5.94781219218678e-07 MirTarget;PITA;miRanda;miRNATAP -0.134283532499914 2.16534408842331e-10 NA NA NA hsa-miR-155-5p STOX2 0.533437622040649 0.00248671179205372 -0.74634022235062 0.00172526546182382 mirMAP -0.329320375295084 1.57975492790294e-08 NA NA NA hsa-miR-155-5p STRN 0.533437622040649 0.00248671179205372 -0.813799283579173 3.10536399221898e-05 miRNAWalker2_validate -0.231298198844287 1.56038474663229e-06 NA NA NA hsa-miR-199a-5p STRN -0.364835768178638 0.0435119211101981 -0.813799283579173 3.10536399221898e-05 miRNATAP -0.17911498236377 0.000152026262962481 NA NA NA hsa-miR-30a-5p STRN -1.79779915425811 1.93360169837799e-26 -0.813799283579173 3.10536399221898e-05 miRNAWalker2_validate;mirMAP -0.161847123740592 0.000776318016016437 NA NA NA hsa-miR-155-5p STRN3 0.533437622040649 0.00248671179205372 0.168279264731002 0.119422964339874 MirTarget;miRNATAP -0.140785830943988 8.96735383847183e-08 NA NA NA hsa-miR-30a-5p STX6 -1.79779915425811 1.93360169837799e-26 0.54595892900829 1.58344625820367e-14 mirMAP -0.155086320996895 1.98790175787283e-19 NA NA NA hsa-miR-199a-5p SUZ12 -0.364835768178638 0.0435119211101981 0.352563133818187 0.000238360395173 miRanda -0.13142360217561 9.86929064592444e-09 NA NA NA hsa-miR-193b-5p SYT2 1.10486595354104 6.41489920661805e-11 -0.296517434970323 0.262631593280977 mirMAP -0.557937892764739 8.44714007782122e-18 NA NA NA hsa-miR-199a-5p TAB3 -0.364835768178638 0.0435119211101981 -0.484377900379147 1.15000753706731e-06 MirTarget;PITA;miRanda -0.140787950244182 3.80121508578079e-09 NA NA NA hsa-miR-199a-5p TAF4B -0.364835768178638 0.0435119211101981 0.257118869525126 0.0860034233754449 miRanda -0.133133918519487 0.000216654711134478 NA NA NA hsa-miR-199a-5p TAOK1 -0.364835768178638 0.0435119211101981 -0.381285817103181 0.0772091138704751 MirTarget;miRanda;miRNATAP -0.166992280630905 0.00131568697197349 NA NA NA hsa-miR-30a-5p TAOK1 -1.79779915425811 1.93360169837799e-26 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.194590756858791 0.000226597165407546 NA NA NA hsa-miR-155-5p TBC1D14 0.533437622040649 0.00248671179205372 -0.284847161266542 0.00256665479051085 miRNAWalker2_validate -0.116399008263679 4.73246849008124e-07 NA NA NA hsa-miR-155-5p TBC1D16 0.533437622040649 0.00248671179205372 0.0430977114409137 0.7549949368765 mirMAP -0.211628816542055 2.55545161516442e-10 NA NA NA hsa-miR-155-5p TBC1D8B 0.533437622040649 0.00248671179205372 0.0622359242534953 0.691367332658177 miRNAWalker2_validate -0.258740764938069 8.48689023218551e-12 NA NA NA hsa-miR-155-5p TCF12 0.533437622040649 0.00248671179205372 -0.188904215206123 0.109343801942825 miRNAWalker2_validate -0.101446734076262 0.000465645817122519 NA NA NA hsa-miR-199a-5p TCOF1 -0.364835768178638 0.0435119211101981 0.821618389907453 2.85125627326646e-17 miRanda -0.11274494365566 2.61819736484186e-06 NA NA NA hsa-miR-30a-5p TDG -1.79779915425811 1.93360169837799e-26 0.379639290945487 4.47049072611284e-06 mirMAP;miRNATAP -0.16873477411804 1.43434570544262e-17 NA NA NA hsa-miR-199a-5p TEX10 -0.364835768178638 0.0435119211101981 0.414712399730036 6.61602552881609e-07 miRanda -0.105289536904358 1.5410302226721e-07 NA NA NA hsa-miR-199a-5p TFAM -0.364835768178638 0.0435119211101981 0.124646318904861 0.13366754810431 MirTarget -0.135481736375169 4.64126435961321e-12 NA NA NA hsa-miR-30a-5p TFDP1 -1.79779915425811 1.93360169837799e-26 0.247359691303701 0.010818277948758 MirTarget;miRNATAP -0.112671547311556 1.83160590224895e-06 NA NA NA hsa-miR-193b-5p TFDP2 1.10486595354104 6.41489920661805e-11 0.425669422468068 0.0013716846266445 mirMAP -0.159760614466275 1.88020745265091e-06 NA NA NA hsa-miR-155-5p TFRC 0.533437622040649 0.00248671179205372 1.13315492496779 9.25364438619647e-11 mirMAP -0.109671055062862 0.0126053954060675 NA NA NA hsa-miR-199a-5p TFRC -0.364835768178638 0.0435119211101981 1.13315492496779 9.25364438619647e-11 miRanda -0.123610328347246 0.00400160740164505 NA NA NA hsa-miR-30a-5p TFRC -1.79779915425811 1.93360169837799e-26 1.13315492496779 9.25364438619647e-11 mirMAP -0.201015796670171 3.62258553971069e-06 NA NA NA hsa-miR-199a-5p TGFA -0.364835768178638 0.0435119211101981 0.471727986880251 0.0113818927785784 miRNATAP -0.227002907986154 3.66131696673185e-07 NA NA NA hsa-miR-30a-5p TGFBI -1.79779915425811 1.93360169837799e-26 2.96842077099196 5.42111172373249e-26 miRNAWalker2_validate -0.545077010044602 1.50734932970056e-14 NA NA NA hsa-miR-155-5p THBS1 0.533437622040649 0.00248671179205372 -0.0602688709574686 0.817102472377875 miRNAWalker2_validate;mirMAP -0.17476722608862 0.006488079922108 NA NA NA hsa-miR-148a-5p TIMP3 -1.00478606532747 1.38045244999229e-07 -0.108564734035578 0.663080057862363 mirMAP -0.146693071577087 0.0091074225777052 NA NA NA hsa-miR-155-5p TJP1 0.533437622040649 0.00248671179205372 -0.868639096328216 5.8057163643466e-13 miRNAWalker2_validate -0.146982247869885 1.09710321469528e-06 NA NA NA hsa-miR-148a-5p TMC7 -1.00478606532747 1.38045244999229e-07 1.55281752021407 1.13184923233452e-16 mirMAP -0.268709814681318 4.09490135840463e-10 NA NA NA hsa-miR-30a-5p TMCC1 -1.79779915425811 1.93360169837799e-26 0.271383205638537 0.00498769283302343 miRNATAP -0.137945992831937 3.72762569682196e-09 NA NA NA hsa-miR-155-5p TMEM132B 0.533437622040649 0.00248671179205372 -1.65929253427269 8.29453164825669e-11 mirMAP -0.311243282164259 1.03211898321041e-06 NA NA NA hsa-miR-193b-5p TMEM132B 1.10486595354104 6.41489920661805e-11 -1.65929253427269 8.29453164825669e-11 mirMAP -0.27242696473399 3.30195536537872e-05 NA NA NA hsa-miR-199a-5p TMEM154 -0.364835768178638 0.0435119211101981 -0.43065471847775 0.0565765545224511 miRanda -0.137686782102612 0.0115809501689632 NA NA NA hsa-miR-30a-5p TMEM33 -1.79779915425811 1.93360169837799e-26 0.157713119729981 0.0770901032602469 mirMAP -0.135700102173967 2.67279703159178e-10 NA NA NA hsa-miR-155-5p TMEM47 0.533437622040649 0.00248671179205372 -0.806653580223931 0.00010519969644495 mirMAP -0.181990840879595 0.000406862457347072 NA NA NA hsa-miR-199a-5p TMEM54 -0.364835768178638 0.0435119211101981 0.445993645296739 0.00231422148420345 miRTarBase -0.107471522449624 0.00237318193232856 NA NA NA hsa-miR-148a-5p TMEM86A -1.00478606532747 1.38045244999229e-07 0.224628016096871 0.264373563443549 mirMAP -0.107970418852389 0.0175572868955213 NA NA NA hsa-miR-30a-5p TMEM87B -1.79779915425811 1.93360169837799e-26 0.230520019915467 0.00530885972594543 MirTarget -0.15578143113261 2.93940325602668e-15 NA NA NA hsa-miR-145-5p TMOD3 -0.46917511594055 0.000685297625493134 -0.536997317538313 4.42612962054079e-06 miRNAWalker2_validate -0.103662416199208 0.00525038197750576 NA NA NA hsa-miR-155-5p TMOD3 0.533437622040649 0.00248671179205372 -0.536997317538313 4.42612962054079e-06 miRNAWalker2_validate -0.116673902391152 5.54336062435191e-05 NA NA NA hsa-miR-199a-5p TMPO -0.364835768178638 0.0435119211101981 0.421992301096901 0.000452400567480576 miRanda -0.176555083293056 7.59669038102396e-10 NA NA NA hsa-miR-199a-5p TMPRSS13 -0.364835768178638 0.0435119211101981 -0.357213696164017 0.146424264127585 miRanda -0.137065648847728 0.0209806343431364 NA NA NA hsa-miR-155-5p TMTC3 0.533437622040649 0.00248671179205372 0.729016845766032 3.10685451870563e-11 miRNAWalker2_validate -0.121388231909856 9.42875757071583e-06 NA NA NA hsa-miR-30a-5p TMTC3 -1.79779915425811 1.93360169837799e-26 0.729016845766032 3.10685451870563e-11 mirMAP -0.191059627474181 1.11420324435179e-12 NA NA NA hsa-miR-145-5p TNFRSF10A -0.46917511594055 0.000685297625493134 0.134151747453153 0.349659945320127 MirTarget -0.179073726992412 6.80103048689331e-05 NA NA NA hsa-miR-30a-5p TNFRSF10B -1.79779915425811 1.93360169837799e-26 0.899245000221647 4.39740185337371e-13 miRNAWalker2_validate -0.100563840293477 0.00121972811884754 NA NA NA hsa-miR-143-5p TNFSF14 0.502923736905281 0.00432190530694735 0.00762268411608935 0.977601922831854 mirMAP -0.188430750587125 0.00488539735237308 NA NA NA hsa-miR-199a-5p TNFSF14 -0.364835768178638 0.0435119211101981 0.00762268411608935 0.977601922831854 miRanda -0.173151588083076 0.00813732777528623 NA NA NA hsa-miR-155-5p TNKS1BP1 0.533437622040649 0.00248671179205372 0.137877363124939 0.189524242634817 miRNAWalker2_validate -0.100105306070708 0.000101876373034135 NA NA NA hsa-miR-30a-5p TNPO3 -1.79779915425811 1.93360169837799e-26 -0.0573831664411752 0.624633187532402 miRNAWalker2_validate -0.121788932270979 1.97616507363625e-05 NA NA NA hsa-miR-148a-5p TOLLIP -1.00478606532747 1.38045244999229e-07 -0.377845584849829 0.000251191180923252 MirTarget -0.112990732755521 1.11683027265348e-06 NA NA NA hsa-miR-199a-5p TOP1 -0.364835768178638 0.0435119211101981 0.0778676232397961 0.451794591840351 miRanda -0.107397813144483 1.42726327752603e-05 NA NA NA hsa-miR-139-5p TOP2A -1.46099200329485 7.85040381494472e-22 1.68873556941403 1.09671629271911e-25 miRanda -0.306246679053315 2.31528861445235e-11 26079880 We identified that miR-139 a previous reported anti-metastatic microRNA targets 3'-untranslated region 3'UTR of TOP2a mRNA; Further more we revealed that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels; And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139 breast cancer hsa-miR-30a-5p TP63 -1.79779915425811 1.93360169837799e-26 0.976250005346845 1.632523718912e-07 mirMAP -0.387718109813168 4.92773037425648e-18 NA NA NA hsa-miR-30a-5p TPBG -1.79779915425811 1.93360169837799e-26 1.51663916580591 6.88647536683999e-31 miRNAWalker2_validate -0.257058259181559 1.28743531899042e-14 NA NA NA hsa-miR-30a-5p TPI1 -1.79779915425811 1.93360169837799e-26 0.426952451262904 1.56296038764848e-05 miRNAWalker2_validate -0.105963718385531 1.22734371284183e-05 NA NA NA hsa-miR-30a-5p TPM4 -1.79779915425811 1.93360169837799e-26 0.0626616582248491 0.516374121207015 miRNATAP -0.130878623510706 2.01683607107756e-08 NA NA NA hsa-miR-193b-5p TPPP 1.10486595354104 6.41489920661805e-11 -1.42915199435457 2.01034234601577e-09 mirMAP -0.164666517403766 0.00724836412154787 NA NA NA hsa-miR-148a-5p TPST2 -1.00478606532747 1.38045244999229e-07 0.571205425166802 1.98018051847253e-10 MirTarget -0.115811080496869 1.24615099034276e-08 NA NA NA hsa-miR-199a-5p TRIB1 -0.364835768178638 0.0435119211101981 -0.247013769872912 0.074125017589428 miRanda -0.123819506096398 0.000195065791913936 NA NA NA hsa-miR-155-5p TRIM2 0.533437622040649 0.00248671179205372 -1.08899771126773 9.56102077886118e-07 miRNATAP -0.196029289419314 0.000386466927762661 NA NA NA hsa-miR-199a-5p TRIM36 -0.364835768178638 0.0435119211101981 0.908535619783598 1.43589157240973e-06 miRanda -0.106558553407918 0.0203875022106514 NA NA NA hsa-miR-30a-5p TRIM9 -1.79779915425811 1.93360169837799e-26 0.84495257783875 0.00237295995363363 miRNATAP -0.218087346279628 0.00141378855050435 NA NA NA hsa-miR-155-5p TRIO 0.533437622040649 0.00248671179205372 0.818583146315065 2.61629604806464e-07 miRNAWalker2_validate -0.176796310986429 7.19736893483187e-06 NA NA NA hsa-miR-30a-5p TRIO -1.79779915425811 1.93360169837799e-26 0.818583146315065 2.61629604806464e-07 miRNAWalker2_validate -0.185414703464736 2.15510454246437e-06 NA NA NA hsa-miR-155-5p TSHZ3 0.533437622040649 0.00248671179205372 0.949816173372488 2.02684220670059e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.136298547736974 0.00617292577399307 NA NA NA hsa-miR-155-5p TSPAN5 0.533437622040649 0.00248671179205372 -0.0286106339562444 0.8816611887669 MirTarget -0.149112127871038 0.00161028617007384 NA NA NA hsa-miR-193b-5p TTBK1 1.10486595354104 6.41489920661805e-11 1.58510264175175 2.76374866735066e-12 mirMAP -0.166577486290144 0.00453447333229178 NA NA NA hsa-miR-199a-5p TTC39A -0.364835768178638 0.0435119211101981 -1.66107503996381 8.23590752372248e-11 miRanda -0.184246413645814 0.00335625725839377 NA NA NA hsa-miR-199a-5p TTC9 -0.364835768178638 0.0435119211101981 -2.06768076881877 2.85281167189342e-17 miRNATAP -0.196857035522429 0.00122053493149495 NA NA NA hsa-miR-139-5p TTK -1.46099200329485 7.85040381494472e-22 1.58386491735199 9.79060899849686e-29 miRanda -0.215849016952399 1.46206118913392e-07 NA NA NA hsa-miR-338-5p TTK -1.71946558699173 2.62649071488641e-23 1.58386491735199 9.79060899849686e-29 PITA -0.126880959590384 0.000464328628582499 NA NA NA hsa-miR-148a-5p TTPAL -1.00478606532747 1.38045244999229e-07 0.821148270896643 2.06214524544565e-11 mirMAP -0.128923544857036 4.19397280708488e-06 NA NA NA hsa-miR-199a-5p TUBAL3 -0.364835768178638 0.0435119211101981 0.544119427330744 0.0340830133119936 miRanda -0.153408086771967 0.0134027768283421 NA NA NA hsa-miR-30a-5p TUBB3 -1.79779915425811 1.93360169837799e-26 1.85344081120767 1.19076912880467e-17 miRNAWalker2_validate -0.46588871193524 1.90401922489096e-18 NA NA NA hsa-miR-199a-5p TUBG1 -0.364835768178638 0.0435119211101981 0.600536787193962 1.99337542747954e-14 miRanda;miRNATAP -0.128552429115409 1.3695869889797e-11 NA NA NA hsa-miR-30a-5p TWF1 -1.79779915425811 1.93360169837799e-26 -0.0669860629623482 0.501734743001295 miRNAWalker2_validate;MirTarget;miRNATAP -0.154171979521257 1.28960174488044e-10 NA NA NA hsa-miR-155-5p TXNRD1 0.533437622040649 0.00248671179205372 0.620997196328642 0.00145986335995137 miRNAWalker2_validate -0.204731679620377 2.03086771845161e-05 NA NA NA hsa-miR-155-5p TYRP1 0.533437622040649 0.00248671179205372 -1.7162870870401 2.93386488062316e-05 MirTarget -0.436969092437951 1.67685315362123e-05 26068396 SNPs at miR 155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma; The effect of miR-155 on TYRP1 mRNA/protein expression was evaluated in two melanoma cell lines harbouring matched or mismatched miR-155-TYRP1 mRNA interaction after transfection with pre-miR-155; In parallel 192 skin and lymph node melanoma metastases were examined for TYRP1 mRNA/protein miR-155 and SNPs and correlated with patient survival; TYRP1 mRNA SNPs at its 3'UTR and miR-155 were analysed by RT-qPCR whereas TYRP1 protein was evaluated by western blot in cell lines and by immunohistochemistry in metastatic tissues; The miR-155 induced a dose-dependent TYRP1 mRNA decay and hampered its translation into protein in the line with the 'match' genotype; In melanoma metastases TYRP1 mRNA inversely correlated with miR-155 expression but not with TYRP1 protein in the 'match' group whereas it positively correlated with protein but not with miR-155 in the 'mismatch' group; Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein; These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity and disclose a prognostic value for TYRP1 protein in a subgroup of melanoma patients metastasis;poor survival melanoma hsa-miR-145-5p UBA6 -0.46917511594055 0.000685297625493134 0.562843216190472 1.1957908652734e-06 MirTarget -0.147093469043733 6.09679629605239e-05 NA NA NA hsa-miR-199a-5p UBASH3A -0.364835768178638 0.0435119211101981 0.0513062951846659 0.853295936000592 miRanda -0.156001839036591 0.0197409651192753 NA NA NA hsa-miR-140-3p UBE2C -0.967453553824782 7.6999446305445e-23 2.09091647909598 5.68983461301196e-44 miRNAWalker2_validate;miRNATAP -0.451870961277947 6.1369437299272e-11 NA NA NA hsa-miR-148a-5p UBE2E3 -1.00478606532747 1.38045244999229e-07 0.276362593852793 0.000230627525488299 MirTarget;miRNATAP -0.13988970916573 1.81752899416927e-17 NA NA NA hsa-miR-155-5p UBE2H 0.533437622040649 0.00248671179205372 -0.0618998197793568 0.557523264688667 miRNAWalker2_validate -0.173416219026121 9.89165755103791e-12 NA NA NA hsa-miR-30a-5p UBE2H -1.79779915425811 1.93360169837799e-26 -0.0618998197793568 0.557523264688667 miRNAWalker2_validate -0.131621929690918 2.63564378716771e-07 NA NA NA hsa-miR-148a-5p UBE2R2 -1.00478606532747 1.38045244999229e-07 0.151845831032726 0.102833154468228 mirMAP -0.101661126031176 1.02615616041473e-06 NA NA NA hsa-miR-30a-5p UBE2V2 -1.79779915425811 1.93360169837799e-26 0.538514145997373 7.64067964699922e-09 MirTarget -0.1194489016278 1.87748181634972e-07 NA NA NA hsa-miR-30a-5p UBE3C -1.79779915425811 1.93360169837799e-26 0.0104134199226262 0.908166823629394 MirTarget;miRNATAP -0.104530957125076 1.78479717019685e-06 27003255 In this study we report that UBE3C was a direct target of miR-30a-5p; Expression of miR-30a-5p in BC cells reduced UBE3C expression; Moreover Correlation analysis indicated that expression of miR-30a-5p was highly negatively correlated with UBE3C which was upregulated in BC specimens; Therefore miR-30a-5p activation or UBE3C inhibition may be provide a novel strategy for the treatment of BC breast cancer hsa-miR-155-5p UBN2 0.533437622040649 0.00248671179205372 -0.277117372449649 0.00305410526467861 mirMAP -0.118635634799294 2.11643427133302e-07 NA NA NA hsa-miR-155-5p UBR3 0.533437622040649 0.00248671179205372 -0.707118171943656 1.54398716412151e-11 miRNATAP -0.215058290131207 3.98392201667259e-17 NA NA NA hsa-miR-145-5p UBXN7 -0.46917511594055 0.000685297625493134 0.720263126666859 3.66553629759639e-06 mirMAP -0.142973967523169 0.00382323847077872 NA NA NA hsa-miR-199a-5p UEVLD -0.364835768178638 0.0435119211101981 -0.178005760887528 0.117358938763661 miRanda -0.119870075958104 1.05878140976079e-05 NA NA NA hsa-miR-155-5p UGDH 0.533437622040649 0.00248671179205372 0.137718660496197 0.370428737241388 miRNAWalker2_validate -0.159118741182695 2.40912919124872e-05 NA NA NA hsa-miR-30a-5p UGDH -1.79779915425811 1.93360169837799e-26 0.137718660496197 0.370428737241388 miRNAWalker2_validate -0.142352605458591 0.000148693400391818 NA NA NA hsa-miR-155-5p UHMK1 0.533437622040649 0.00248671179205372 -0.241700896539452 0.31483869929113 mirMAP -0.153396036710946 0.00967406016174139 NA NA NA hsa-miR-199a-5p UHMK1 -0.364835768178638 0.0435119211101981 -0.241700896539452 0.31483869929113 miRNATAP -0.25486314605906 9.7489278442675e-06 NA NA NA hsa-miR-155-5p UNC5C 0.533437622040649 0.00248671179205372 0.203211830722605 0.54399060369743 MirTarget -0.17278741901416 0.0365808338257674 NA NA NA hsa-miR-155-5p UST 0.533437622040649 0.00248671179205372 0.13543776127503 0.464676150157314 miRNATAP -0.192697345355789 2.18965536598107e-05 NA NA NA hsa-miR-30a-5p VANGL2 -1.79779915425811 1.93360169837799e-26 0.557110439932697 0.00123817750760716 mirMAP -0.123121398766576 0.00370527680968325 NA NA NA hsa-miR-148a-5p VAPA -1.00478606532747 1.38045244999229e-07 -0.114587653411004 0.139130769050582 mirMAP -0.100512134689195 5.11864319709435e-09 NA NA NA hsa-miR-155-5p VGLL3 0.533437622040649 0.00248671179205372 0.000351466349602259 0.998930799401018 mirMAP -0.223397807142609 0.000530618440677212 NA NA NA hsa-miR-193b-5p VIPR2 1.10486595354104 6.41489920661805e-11 -2.40129627976091 1.62305171244271e-13 MirTarget -0.459436532158246 3.8851307522386e-08 NA NA NA hsa-miR-155-5p VKORC1L1 0.533437622040649 0.00248671179205372 0.0752933175219894 0.349386673298439 mirMAP -0.143643827200037 1.00263251421652e-13 NA NA NA hsa-miR-199a-5p VPS13A -0.364835768178638 0.0435119211101981 -0.401647272298255 0.000501695621056192 miRanda -0.136446235034135 8.3815716544998e-07 NA NA NA hsa-miR-155-5p VPS13B 0.533437622040649 0.00248671179205372 0.244278798851878 0.025566217120092 mirMAP -0.107326147176778 6.4268016560945e-05 NA NA NA hsa-miR-155-5p VPS36 0.533437622040649 0.00248671179205372 -0.635393759466094 3.67498870722807e-12 miRNAWalker2_validate -0.103132271215674 6.31140279091609e-06 NA NA NA hsa-miR-155-5p WDFY3 0.533437622040649 0.00248671179205372 -0.443009350738278 7.40398135763533e-05 miRNATAP -0.170117693844795 4.5172446066782e-10 NA NA NA hsa-miR-126-5p WDHD1 -0.953529188793816 7.91719143295591e-16 1.49792173560178 2.89240871750159e-31 MirTarget;mirMAP -0.158621398034679 0.00125179840886497 NA NA NA hsa-miR-195-3p WDHD1 -0.624259620429699 0.000164279659144497 1.49792173560178 2.89240871750159e-31 mirMAP -0.110132765876248 0.00223674914444517 NA NA NA hsa-miR-26b-5p WDHD1 -0.254478038884324 0.0285227763044636 1.49792173560178 2.89240871750159e-31 miRNAWalker2_validate;mirMAP -0.230392116454886 7.11995405486591e-06 NA NA NA hsa-miR-29b-2-5p WDHD1 -0.502720326849742 0.000730448246894952 1.49792173560178 2.89240871750159e-31 MirTarget -0.153982170693239 0.000113137681320812 NA NA NA hsa-miR-338-5p WDHD1 -1.71946558699173 2.62649071488641e-23 1.49792173560178 2.89240871750159e-31 mirMAP -0.136371824481988 3.33981359381442e-05 NA NA NA hsa-miR-199a-5p WDR44 -0.364835768178638 0.0435119211101981 -0.026779134149499 0.814077502832874 MirTarget;PITA;miRanda;miRNATAP -0.122793361562488 6.43687671385192e-06 NA NA NA hsa-miR-30a-5p WDR44 -1.79779915425811 1.93360169837799e-26 -0.026779134149499 0.814077502832874 MirTarget;miRNATAP -0.145307210471482 1.37187039865147e-07 NA NA NA hsa-miR-155-5p WDR72 0.533437622040649 0.00248671179205372 0.781671087491785 0.133530700810236 MirTarget -0.543827344953857 2.11428854048152e-05 NA NA NA hsa-miR-30a-5p WDR75 -1.79779915425811 1.93360169837799e-26 0.517075932165914 9.43819404336845e-12 miRNAWalker2_validate -0.101977460478397 5.08877277580863e-08 NA NA NA hsa-miR-199a-5p WDR76 -0.364835768178638 0.0435119211101981 0.953190484316742 6.03625791764224e-10 MirTarget;miRNATAP -0.233894523764012 3.16839270939797e-10 NA NA NA hsa-miR-155-5p WNK1 0.533437622040649 0.00248671179205372 -0.160136499682516 0.197817590816464 miRNATAP -0.149129043544279 9.10703649967915e-07 NA NA NA hsa-miR-155-5p WNT5A 0.533437622040649 0.00248671179205372 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.292461135450501 1.33940668925285e-08 NA NA NA hsa-miR-30a-5p WNT5A -1.79779915425811 1.93360169837799e-26 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.17873480778717 0.000544504752065439 NA NA NA hsa-miR-30a-5p WNT7B -1.79779915425811 1.93360169837799e-26 1.7004681714238 2.27477787935058e-17 miRNATAP -0.466902672834237 1.18370343078737e-21 NA NA NA hsa-miR-155-5p WWC1 0.533437622040649 0.00248671179205372 -1.127808904 4.77753162776302e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.125453829862481 0.000150299688237702 NA NA NA hsa-miR-155-5p WWTR1 0.533437622040649 0.00248671179205372 -0.274990048461166 0.0613972004668567 mirMAP -0.160385032075728 8.53269337857818e-06 NA NA NA hsa-miR-30a-5p WWTR1 -1.79779915425811 1.93360169837799e-26 -0.274990048461166 0.0613972004668567 MirTarget -0.100180713092877 0.00543514830586714 NA NA NA hsa-miR-199a-5p XAF1 -0.364835768178638 0.0435119211101981 1.67868282031898 5.84758237166664e-14 miRanda -0.11811567190054 0.0329110569856399 NA NA NA hsa-miR-193b-5p XK 1.10486595354104 6.41489920661805e-11 -1.30485031036466 1.62807188199702e-05 MirTarget -0.298628676060164 0.000104778020510531 NA NA NA hsa-miR-30a-5p XPOT -1.79779915425811 1.93360169837799e-26 0.489344781855153 2.44663738596609e-06 miRNAWalker2_validate -0.187007455723949 8.72086914369798e-14 NA NA NA hsa-miR-30a-5p XPR1 -1.79779915425811 1.93360169837799e-26 1.00639769954328 5.85634467811677e-17 MirTarget;miRNATAP -0.199721501438408 2.3053564466714e-11 NA NA NA hsa-miR-145-5p XRN1 -0.46917511594055 0.000685297625493134 0.290515665799887 0.0120502785063759 MirTarget;miRNATAP -0.175038820111158 1.33309208692933e-06 NA NA NA hsa-miR-193b-5p XYLB 1.10486595354104 6.41489920661805e-11 -0.407648065549471 0.0038276624715081 MirTarget -0.171043553475432 1.44228841322858e-06 NA NA NA hsa-miR-148a-5p YBX1 -1.00478606532747 1.38045244999229e-07 0.266278278363655 0.000539202046969309 MirTarget -0.102738534878092 2.08987714662109e-09 NA NA NA hsa-miR-155-5p YIPF6 0.533437622040649 0.00248671179205372 -0.0991696922330298 0.253124890919333 mirMAP -0.171890162979485 1.03119336685393e-16 NA NA NA hsa-miR-199a-5p YTHDC2 -0.364835768178638 0.0435119211101981 -0.463504589413699 3.8334014041896e-06 miRanda -0.10814033100649 7.96355661862278e-06 NA NA NA hsa-miR-30a-5p YWHAG -1.79779915425811 1.93360169837799e-26 0.330299865053775 0.000136511662733804 miRNATAP -0.146711637270905 2.05639265713117e-12 NA NA NA hsa-miR-30a-5p YWHAZ -1.79779915425811 1.93360169837799e-26 0.344806894705046 0.00159832448868044 miRNAWalker2_validate;MirTarget;miRNATAP -0.257456100150205 1.20682025865332e-23 NA NA NA hsa-miR-193b-5p ZADH2 1.10486595354104 6.41489920661805e-11 -0.720724840046419 5.59452320516825e-13 mirMAP -0.186954038540519 1.41500050296082e-13 NA NA NA hsa-miR-155-5p ZBTB10 0.533437622040649 0.00248671179205372 -0.548890991823764 0.0231281353077269 mirMAP -0.132451777307509 0.0266449162828291 NA NA NA hsa-miR-30a-5p ZBTB11 -1.79779915425811 1.93360169837799e-26 0.321091098454429 0.000205165934506835 MirTarget -0.131949938359264 2.89387077711021e-10 NA NA NA hsa-miR-199a-5p ZBTB5 -0.364835768178638 0.0435119211101981 -0.212190143105498 0.0388166709605196 PITA;miRNATAP -0.100401575943741 4.56763947154981e-05 NA NA NA hsa-miR-145-5p ZC3H3 -0.46917511594055 0.000685297625493134 0.437118888359888 3.78652706085064e-08 MirTarget -0.107963468578781 1.76266458755865e-05 NA NA NA hsa-miR-30a-5p ZC3HAV1 -1.79779915425811 1.93360169837799e-26 0.235756873095552 0.0087475867847393 mirMAP -0.117694302113259 6.75582520755388e-08 NA NA NA hsa-miR-199a-5p ZCCHC2 -0.364835768178638 0.0435119211101981 -0.0512044918598962 0.625443783649462 PITA;miRanda;miRNATAP -0.132636198000208 1.08618872165814e-07 NA NA NA hsa-miR-30a-5p ZCCHC6 -1.79779915425811 1.93360169837799e-26 -0.24953360394843 0.0309970542139858 MirTarget -0.112910996445309 6.37049312817787e-05 NA NA NA hsa-miR-193b-5p ZDHHC11 1.10486595354104 6.41489920661805e-11 -0.301712340729683 0.315611651755695 MirTarget -0.465973019197888 5.13542835363045e-10 NA NA NA hsa-miR-155-5p ZDHHC15 0.533437622040649 0.00248671179205372 -3.30393347585066 2.8823556098724e-25 mirMAP -0.171396351175546 0.037942131591452 NA NA NA hsa-miR-30a-5p ZDHHC20 -1.79779915425811 1.93360169837799e-26 -0.587726250185728 0.012812647462193 MirTarget -0.195931874439863 0.000715090321653072 NA NA NA hsa-miR-148a-5p ZFP42 -1.00478606532747 1.38045244999229e-07 1.57167104581438 0.000673819497583806 MirTarget -0.373083509744349 0.000363549082369499 NA NA NA hsa-miR-199a-5p ZFR2 -0.364835768178638 0.0435119211101981 0.422880188216589 0.372773006497113 miRanda -0.283494719201713 0.0132585629893477 NA NA NA hsa-miR-145-5p ZFYVE26 -0.46917511594055 0.000685297625493134 0.295001268588269 0.00145582178224356 MirTarget -0.132048263963844 5.4792953181291e-06 NA NA NA hsa-miR-30a-5p ZFYVE26 -1.79779915425811 1.93360169837799e-26 0.295001268588269 0.00145582178224356 miRNATAP -0.152578438460088 8.22594189717636e-12 NA NA NA hsa-miR-30a-5p ZIC2 -1.79779915425811 1.93360169837799e-26 4.72482857788529 2.35782642766569e-48 miRNATAP -0.592492201569812 4.92911916625746e-12 NA NA NA hsa-miR-155-5p ZNF254 0.533437622040649 0.00248671179205372 -1.01400298678287 2.06040574036967e-06 miRNAWalker2_validate -0.117467916906538 0.0273679610719478 NA NA NA hsa-miR-155-5p ZNF273 0.533437622040649 0.00248671179205372 -0.235428417645361 0.0833745286706803 miRNAWalker2_validate -0.150785672822865 5.95264263592943e-06 NA NA NA hsa-miR-155-5p ZNF28 0.533437622040649 0.00248671179205372 -0.305443226685893 0.142332742048708 miRNAWalker2_validate -0.10993052223233 0.0324607024085339 NA NA NA hsa-miR-199a-5p ZNF281 -0.364835768178638 0.0435119211101981 0.803586328309668 0.000121759327726292 miRanda -0.145433109538542 0.00413232221284156 NA NA NA hsa-miR-199a-5p ZNF367 -0.364835768178638 0.0435119211101981 0.890736125559594 1.91129094707727e-08 miRanda -0.197609991308127 2.63548348472301e-07 NA NA NA hsa-miR-193b-5p ZNF514 1.10486595354104 6.41489920661805e-11 -0.198360769005007 0.10360747519404 MirTarget -0.151383825429546 7.34352355582619e-07 NA NA NA hsa-miR-155-5p ZNF528 0.533437622040649 0.00248671179205372 -0.723318467784545 0.0046298730965055 mirMAP -0.213933380225643 0.000690811851513575 NA NA NA hsa-miR-199a-5p ZNF562 -0.364835768178638 0.0435119211101981 -0.127650268470433 0.179381930739659 miRanda -0.109888741181408 1.27514716469342e-06 NA NA NA hsa-miR-199a-5p ZNF641 -0.364835768178638 0.0435119211101981 -0.272557338253772 0.100505359522705 miRanda -0.11069589181598 0.0056567069160202 NA NA NA hsa-miR-155-5p ZNF664 0.533437622040649 0.00248671179205372 0.0253462800467785 0.789826654582003 miRNATAP -0.130958638379917 1.41310263399293e-08 NA NA NA hsa-miR-155-5p ZNF703 0.533437622040649 0.00248671179205372 -0.427912587976199 0.0300060813652142 miRNATAP -0.256758561498893 9.93945480086235e-08 NA NA NA hsa-miR-199a-5p ZNF710 -0.364835768178638 0.0435119211101981 -0.484005837206953 0.000769483545141928 miRanda;miRNATAP -0.134945611051305 0.000100495854397834 NA NA NA hsa-miR-30a-5p ZNF746 -1.79779915425811 1.93360169837799e-26 0.301927485946035 0.000198239365199757 MirTarget -0.115229487947108 4.72972203258493e-09 NA NA NA hsa-miR-30a-5p ZNF770 -1.79779915425811 1.93360169837799e-26 -0.404027724509239 0.0010981236755381 mirMAP -0.152889332538409 4.02883242467602e-07 NA NA NA hsa-miR-193b-5p ZNF793 1.10486595354104 6.41489920661805e-11 -1.78087657164683 2.13321700623163e-08 MirTarget -0.432687072562911 8.64882904192623e-08 NA NA NA hsa-miR-155-5p ZNRF3 0.533437622040649 0.00248671179205372 -0.105798692189141 0.321906733175427 miRNATAP -0.172607665955464 2.26142714935273e-11 NA NA NA hsa-miR-199a-5p ZPBP2 -0.364835768178638 0.0435119211101981 0.451075019320024 0.167097462184665 miRanda -0.224440807680051 0.00435677390647009 NA NA NA