miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-21-5p AKT2 1.75445050487988 2.41825549682022e-23 -0.0135478038511252 0.922701697200587 miRNAWalker2_validate -0.147206602823392 0.00352458167442573 NA NA NA hsa-miR-29b-3p AKT2 -0.230693226193598 0.367461626035234 -0.0135478038511252 0.922701697200587 MirTarget -0.141689777106604 0.000224365237662475 26512921;26564501;24076586 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3;The expression of miR-29b was significantly upregualted by cisplatin treatmentwhile its target gene AKT2 was downregulated;Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis ;; ovarian cancer;gastric cancer;acute myeloid leukemia hsa-miR-106b-5p AKT3 1.70863907461894 2.04074794107142e-08 -0.748577301508132 0.0693608036068007 miRNATAP -0.368902671357459 6.63579377990938e-05 NA NA NA hsa-miR-107 AKT3 0.904627575346218 4.67936495073904e-05 -0.748577301508132 0.0693608036068007 PITA;miRanda -0.596025797372068 4.38261497597827e-06 NA NA NA hsa-miR-15b-5p AKT3 1.62046407540723 5.42152621571078e-09 -0.748577301508132 0.0693608036068007 miRNATAP -0.359857777182961 0.000407223981183838 NA NA NA hsa-miR-16-5p AKT3 1.00515772948091 5.33912942007619e-06 -0.748577301508132 0.0693608036068007 miRNAWalker2_validate;miRTarBase;miRNATAP -0.473860841884761 0.000305952592817196 NA NA NA hsa-miR-17-3p AKT3 1.31126744284937 3.24768335024185e-07 -0.748577301508132 0.0693608036068007 miRNATAP -0.520864813647553 2.25932722443508e-06 NA NA NA hsa-miR-17-5p AKT3 1.65862087862483 8.45603406215941e-08 -0.748577301508132 0.0693608036068007 TargetScan;miRNATAP -0.276276453758938 0.00270096970703173 NA NA NA hsa-miR-29a-3p AKT3 -0.113012156986374 0.615005009685815 -0.748577301508132 0.0693608036068007 miRNATAP -0.408748871699734 0.00212322174807936 NA NA NA hsa-miR-29b-3p AKT3 -0.230693226193598 0.367461626035234 -0.748577301508132 0.0693608036068007 miRNATAP -0.338134432146425 0.00361456599882575 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 0.583525764322974 0.11837203008551 -0.748577301508132 0.0693608036068007 mirMAP -0.324144417685552 0.000230218736536503 NA NA NA hsa-miR-320b AKT3 1.11183660885284 0.000497971211648503 -0.748577301508132 0.0693608036068007 PITA;miRanda;miRNATAP -0.263235906209639 0.00390234919135454 NA NA NA hsa-miR-335-3p AKT3 2.5197689063267 2.20084506976733e-09 -0.748577301508132 0.0693608036068007 mirMAP -0.224460236877792 0.000742588100170571 NA NA NA hsa-miR-33a-3p AKT3 0.347011402017138 0.321709379745392 -0.748577301508132 0.0693608036068007 mirMAP -0.376513667394311 1.68302152281553e-05 NA NA NA hsa-miR-362-3p AKT3 -0.0349414695893027 0.913780708043777 -0.748577301508132 0.0693608036068007 miRanda -0.37545416085904 3.60412362584734e-05 NA NA NA hsa-miR-362-5p AKT3 -0.354508685915981 0.354912078595613 -0.748577301508132 0.0693608036068007 PITA;TargetScan;miRNATAP -0.231850776707854 0.00252522310690117 NA NA NA hsa-miR-501-3p AKT3 0.731876211669996 0.0270421347018303 -0.748577301508132 0.0693608036068007 miRNATAP -0.389710500003727 8.30408434984544e-06 NA NA NA hsa-miR-502-3p AKT3 -0.16442685491191 0.557471818466728 -0.748577301508132 0.0693608036068007 miRNATAP -0.502835122914366 1.28261107693995e-06 NA NA NA hsa-miR-505-3p AKT3 0.82660100642669 0.00111666333288398 -0.748577301508132 0.0693608036068007 mirMAP -0.351999859841566 0.0023495079245673 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 -0.156004387355895 0.708665170641638 -0.748577301508132 0.0693608036068007 miRNATAP -0.26608196493585 0.000310856014668821 NA NA NA hsa-miR-577 AKT3 0.911619788986754 0.2256062124148 -0.748577301508132 0.0693608036068007 mirMAP -0.230357457399908 2.14832389488646e-09 NA NA NA hsa-miR-616-5p AKT3 0.834052908652744 0.0347835664029363 -0.748577301508132 0.0693608036068007 mirMAP -0.265580906698402 0.000411824587413266 NA NA NA hsa-miR-103a-3p CAB39 0.840525139266028 5.83536475789158e-07 -0.327376317345833 0.050241354462072 MirTarget;miRNATAP -0.236355717997249 0.000775608912180994 NA NA NA hsa-miR-107 CAB39 0.904627575346218 4.67936495073904e-05 -0.327376317345833 0.050241354462072 MirTarget;miRanda;miRNATAP -0.144063059990656 0.00671014086351162 NA NA NA hsa-miR-151a-3p CAB39 1.00322719901751 7.20903658270795e-06 -0.327376317345833 0.050241354462072 MirTarget -0.174954391903466 0.000822198196361956 NA NA NA hsa-miR-15b-5p CAB39 1.62046407540723 5.42152621571078e-09 -0.327376317345833 0.050241354462072 miRNATAP -0.16486822684262 5.20614390355713e-05 NA NA NA hsa-miR-23b-3p CAB39 -0.286465516491361 0.18664668472995 -0.327376317345833 0.050241354462072 MirTarget;miRNATAP -0.151982348073717 0.0062372877765901 NA NA NA hsa-miR-27b-3p CAB39 0.0836323965901755 0.725273923274 -0.327376317345833 0.050241354462072 MirTarget;miRNATAP -0.133194489993284 0.00844568074121745 NA NA NA hsa-miR-374b-3p CAB39 0.999491658196932 0.00126937019814872 -0.327376317345833 0.050241354462072 MirTarget -0.134970851559542 0.000755204469149188 NA NA NA hsa-miR-155-5p CAB39L 1.28707757465885 8.6344688246758e-05 -2.75293335084107 3.06225009925661e-15 miRNAWalker2_validate -0.213577234408284 0.0081239270094959 NA NA NA hsa-miR-214-5p CAB39L 1.03136265998195 0.00140640252296399 -2.75293335084107 3.06225009925661e-15 MirTarget -0.339588451063629 3.00981287762858e-05 NA NA NA hsa-miR-3662 CAB39L 1.82780708047676 0.0054036501346178 -2.75293335084107 3.06225009925661e-15 MirTarget;miRNATAP -0.164617858040063 0.00158239601714862 NA NA NA hsa-miR-542-3p CAB39L 0.757649022262991 0.00210575463285599 -2.75293335084107 3.06225009925661e-15 miRanda -0.389149937654136 0.000325316670285294 NA NA NA hsa-miR-590-3p CAB39L 1.11654983899947 0.000160782154924864 -2.75293335084107 3.06225009925661e-15 miRanda -0.345280396600247 0.000101487329474819 NA NA NA hsa-miR-590-5p CAB39L 1.04171442093217 0.000272475544954865 -2.75293335084107 3.06225009925661e-15 miRanda -0.421532228762684 3.90594142997688e-06 NA NA NA hsa-miR-125a-5p EIF4E2 -0.878090699011564 0.000213630844319685 -0.0270523638767566 0.82668940326952 miRanda -0.151104346013907 2.45983234711003e-05 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.878090699011564 0.000213630844319685 1.10048942322699 0.000734215888573154 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.414005533193724 2.17946619226446e-05 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-106b-5p HIF1A 1.70863907461894 2.04074794107142e-08 0.837030068372412 0.000839528175139087 MirTarget -0.167802822306102 0.00333492904025455 NA NA NA hsa-miR-107 HIF1A 0.904627575346218 4.67936495073904e-05 0.837030068372412 0.000839528175139087 miRNAWalker2_validate;miRTarBase;miRanda -0.359531659282077 6.20183058633611e-06 NA NA NA hsa-miR-139-5p HIF1A -1.83374360776637 1.22019901002824e-09 0.837030068372412 0.000839528175139087 miRanda -0.162264370983123 0.00469202590041469 NA NA NA hsa-miR-151a-3p HIF1A 1.00322719901751 7.20903658270795e-06 0.837030068372412 0.000839528175139087 MirTarget -0.234458462521455 0.00333486662982671 NA NA NA hsa-miR-320c HIF1A 0.455072851945474 0.240613785444485 0.837030068372412 0.000839528175139087 miRanda -0.146570914616352 0.00656355498345466 NA NA NA hsa-miR-330-3p HIF1A 0.798460296022179 0.00746538156533435 0.837030068372412 0.000839528175139087 MirTarget;PITA -0.177923264725505 0.00313165494038062 NA NA NA hsa-miR-338-3p HIF1A -0.959276231066179 0.0191473351014091 0.837030068372412 0.000839528175139087 MirTarget;PITA;miRanda -0.1816114503828 2.64079547478836e-05 NA NA NA hsa-miR-338-5p HIF1A -1.19659203838734 0.0100316010080496 0.837030068372412 0.000839528175139087 MirTarget;PITA;miRNATAP -0.142083993703647 0.000195627392940844 NA NA NA hsa-miR-361-5p HIF1A 0.407725414130987 0.0181260969156347 0.837030068372412 0.000839528175139087 miRanda -0.306375208776554 0.00431549109334927 NA NA NA hsa-miR-660-5p HIF1A -0.0206552819434673 0.938868734063643 0.837030068372412 0.000839528175139087 MirTarget -0.28396448451383 2.10152340867086e-05 NA NA NA hsa-let-7a-3p IGF1 0.503048155002889 0.0411145454335299 -2.08273193234781 0.00135003721777342 mirMAP -0.548762647030196 0.00421892046856383 NA NA NA hsa-let-7b-3p IGF1 0.21838629112113 0.296038413622566 -2.08273193234781 0.00135003721777342 mirMAP -0.635547835878874 0.00549026374201425 NA NA NA hsa-let-7f-1-3p IGF1 1.28704406797397 1.17954701106157e-06 -2.08273193234781 0.00135003721777342 mirMAP -0.851363397411719 5.26675622894171e-07 NA NA NA hsa-miR-103a-2-5p IGF1 0.808041560899298 0.019989162317947 -2.08273193234781 0.00135003721777342 mirMAP -0.553669997923913 3.26136051419373e-05 NA NA NA hsa-miR-130b-3p IGF1 1.32714007211004 4.78676252285191e-05 -2.08273193234781 0.00135003721777342 MirTarget -0.899465743270437 2.58112149375995e-11 NA NA NA hsa-miR-15b-3p IGF1 1.75738933306437 3.00554466232543e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.968826693204176 7.96214227786153e-13 NA NA NA hsa-miR-16-1-3p IGF1 1.43227522002564 3.70920454953168e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.890729087705412 1.88566016831073e-07 NA NA NA hsa-miR-181b-5p IGF1 1.64216500592669 1.89228845300725e-08 -2.08273193234781 0.00135003721777342 mirMAP -0.484722871486351 0.00175444902634641 NA NA NA hsa-miR-186-5p IGF1 0.149964130725901 0.434709542998771 -2.08273193234781 0.00135003721777342 mirMAP -0.854024244188329 0.000614672571310158 NA NA NA hsa-miR-19a-3p IGF1 1.26669687448473 0.000105972838514412 -2.08273193234781 0.00135003721777342 MirTarget -0.774005120681808 1.66575604220791e-08 NA NA NA hsa-miR-19b-1-5p IGF1 1.38738648038895 1.3113681938066e-06 -2.08273193234781 0.00135003721777342 mirMAP -0.926821468239418 1.88689070400957e-09 NA NA NA hsa-miR-19b-3p IGF1 0.759818275708988 0.00652779573186786 -2.08273193234781 0.00135003721777342 MirTarget -0.817907622748148 6.24186432835086e-07 NA NA NA hsa-miR-20a-3p IGF1 1.13957127410163 0.000451087640268489 -2.08273193234781 0.00135003721777342 mirMAP -0.98528355307319 2.65793420646273e-13 NA NA NA hsa-miR-27a-3p IGF1 1.29886998470345 2.68986118553486e-08 -2.08273193234781 0.00135003721777342 miRNAWalker2_validate;miRTarBase -0.616931404496154 0.00158345718629553 NA NA NA hsa-miR-301a-3p IGF1 1.44721900431161 6.35068481036652e-06 -2.08273193234781 0.00135003721777342 MirTarget -0.441884252991246 0.00198755452375828 NA NA NA hsa-miR-301b-3p IGF1 1.10080095582241 0.0715568440482997 -2.08273193234781 0.00135003721777342 MirTarget -0.489626457605712 1.80285281431259e-06 NA NA NA hsa-miR-3065-5p IGF1 -0.241623656423063 0.633116553078159 -2.08273193234781 0.00135003721777342 mirMAP -0.280592172239543 0.00303638700940348 NA NA NA hsa-miR-32-3p IGF1 0.583525764322974 0.11837203008551 -2.08273193234781 0.00135003721777342 mirMAP -0.526531906386405 0.000169656014507106 NA NA NA hsa-miR-320a IGF1 0.593888711838028 0.011897419390526 -2.08273193234781 0.00135003721777342 miRNATAP -0.565003176356916 0.00470570622795822 NA NA NA hsa-miR-320b IGF1 1.11183660885284 0.000497971211648503 -2.08273193234781 0.00135003721777342 miRNATAP -0.636268160611304 8.75874676911532e-06 NA NA NA hsa-miR-320c IGF1 0.455072851945474 0.240613785444485 -2.08273193234781 0.00135003721777342 miRNATAP -0.416076292118249 0.00294415535123176 NA NA NA hsa-miR-33a-3p IGF1 0.347011402017138 0.321709379745392 -2.08273193234781 0.00135003721777342 MirTarget -0.68230953278373 8.05008237434513e-07 NA NA NA hsa-miR-3662 IGF1 1.82780708047676 0.0054036501346178 -2.08273193234781 0.00135003721777342 MirTarget -0.445685489349264 6.10879019924172e-07 NA NA NA hsa-miR-421 IGF1 1.80720854070385 1.59709651202848e-07 -2.08273193234781 0.00135003721777342 PITA -0.446185670355332 0.000667970192973034 NA NA NA hsa-miR-454-3p IGF1 0.625199142970745 0.0134890997402741 -2.08273193234781 0.00135003721777342 MirTarget -0.54504877697133 0.00336959864095608 NA NA NA hsa-miR-486-5p IGF1 -0.627607241830911 0.155274583521138 -2.08273193234781 0.00135003721777342 PITA;miRNATAP -0.376922293558939 0.000339259187750958 NA NA NA hsa-miR-576-5p IGF1 0.625714137488957 0.0417100301848969 -2.08273193234781 0.00135003721777342 PITA;mirMAP;miRNATAP -0.758998498936523 3.66567723101284e-07 NA NA NA hsa-miR-577 IGF1 0.911619788986754 0.2256062124148 -2.08273193234781 0.00135003721777342 PITA -0.356762409648375 6.35759889251154e-09 NA NA NA hsa-miR-590-3p IGF1 1.11654983899947 0.000160782154924864 -2.08273193234781 0.00135003721777342 MirTarget;miRanda;mirMAP;miRNATAP -0.61013399064959 8.43840390366035e-05 NA NA NA hsa-miR-592 IGF1 0.779567202789068 0.204498177014474 -2.08273193234781 0.00135003721777342 mirMAP -0.405253750267835 3.79197293554194e-07 NA NA NA hsa-miR-629-5p IGF1 1.06377074768516 0.000536624707722274 -2.08273193234781 0.00135003721777342 mirMAP -0.88383980266392 1.46631776640132e-09 NA NA NA hsa-miR-940 IGF1 1.64406174271686 0.000690854900107004 -2.08273193234781 0.00135003721777342 MirTarget;PITA;miRNATAP -0.451608062622453 5.12340787556199e-05 NA NA NA hsa-miR-126-5p MAPK1 0.41765430251855 0.0753161203651532 -0.495098981122446 0.000571417199694919 mirMAP -0.124608202204108 0.00475675613750838 NA NA NA hsa-miR-140-3p MAPK1 -0.296251775392129 0.127539826012144 -0.495098981122446 0.000571417199694919 PITA;miRNATAP -0.145247944412064 0.0071251228758136 NA NA NA hsa-miR-140-5p MAPK1 0.208193069681326 0.303002433893804 -0.495098981122446 0.000571417199694919 miRanda -0.168814127617461 0.00108046906118217 NA NA NA hsa-miR-142-5p MAPK1 1.55592486377018 6.69269968016779e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.122335014287939 1.92619380509704e-05 NA NA NA hsa-miR-16-5p MAPK1 1.00515772948091 5.33912942007619e-06 -0.495098981122446 0.000571417199694919 mirMAP -0.128343010905179 0.00527308486345473 NA NA NA hsa-miR-17-3p MAPK1 1.31126744284937 3.24768335024185e-07 -0.495098981122446 0.000571417199694919 mirMAP -0.106169760608366 0.00660645385547114 NA NA NA hsa-miR-32-5p MAPK1 0.415247682945382 0.106458022460373 -0.495098981122446 0.000571417199694919 mirMAP -0.131661373347466 0.00100556712965003 NA NA NA hsa-miR-320a MAPK1 0.593888711838028 0.011897419390526 -0.495098981122446 0.000571417199694919 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.124406693534882 0.00441330639927605 NA NA NA hsa-miR-320b MAPK1 1.11183660885284 0.000497971211648503 -0.495098981122446 0.000571417199694919 PITA;miRanda;miRNATAP -0.118699294587812 0.000165603061513233 NA NA NA hsa-miR-3614-3p MAPK1 0.816988052098069 0.0143572924352078 -0.495098981122446 0.000571417199694919 mirMAP -0.143042145876837 4.60745685333775e-06 NA NA NA hsa-miR-22-5p PDPK1 0.804348748654247 0.000804065112767412 -0.585978828653773 3.50244194477713e-05 miRNATAP -0.125270641474765 0.00305655303487416 NA NA NA hsa-miR-24-3p PDPK1 1.08578167539644 6.18549359075268e-07 -0.585978828653773 3.50244194477713e-05 miRNAWalker2_validate -0.136688130392664 0.00295230377218292 NA NA NA hsa-miR-27a-3p PDPK1 1.29886998470345 2.68986118553486e-08 -0.585978828653773 3.50244194477713e-05 miRNATAP -0.125391103303215 0.00310988885070073 NA NA NA hsa-miR-424-5p PDPK1 1.08509868581983 0.000420473853818268 -0.585978828653773 3.50244194477713e-05 mirMAP -0.125125661094248 0.00011372244973578 NA NA NA hsa-miR-542-3p PDPK1 0.757649022262991 0.00210575463285599 -0.585978828653773 3.50244194477713e-05 mirMAP -0.156103483841085 0.000137438870707711 NA NA NA hsa-miR-326 PGF -0.429748586406214 0.2629894124021 2.28861179569536 2.11563176368074e-07 mirMAP -0.24624077215828 0.00397086059498227 NA NA NA hsa-miR-335-5p PGF 1.59953351087307 5.56170899867314e-05 2.28861179569536 2.11563176368074e-07 miRNATAP -0.282601191101352 0.000396116789925528 NA NA NA hsa-miR-429 PGF 1.40182602301928 0.00900426780286475 2.28861179569536 2.11563176368074e-07 miRNATAP -0.171535690837198 0.00414084556636762 NA NA NA hsa-miR-126-5p PIK3CA 0.41765430251855 0.0753161203651532 0.181162005416898 0.379919524282219 mirMAP -0.230165325454576 0.000229328041159233 NA NA NA hsa-miR-146a-5p PIK3CA 1.82051649415508 2.03651725047679e-05 0.181162005416898 0.379919524282219 mirMAP -0.130514283326015 8.03472410512393e-05 NA NA NA hsa-miR-148a-5p PIK3CA -0.69329616490858 0.0793012233740369 0.181162005416898 0.379919524282219 mirMAP -0.160710142606256 9.74691916818117e-06 NA NA NA hsa-miR-148b-3p PIK3CA 0.295175884456199 0.17466422420702 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.270665697414514 6.25461929338548e-05 NA NA NA hsa-miR-186-5p PIK3CA 0.149964130725901 0.434709542998771 0.181162005416898 0.379919524282219 mirMAP -0.283664174467296 0.000254482000083255 NA NA NA hsa-miR-29b-1-5p PIK3CA 0.606560155953522 0.116355599574769 0.181162005416898 0.379919524282219 mirMAP -0.105962073023743 0.00514891759991948 NA NA NA hsa-miR-320b PIK3CA 1.11183660885284 0.000497971211648503 0.181162005416898 0.379919524282219 miRanda -0.131928082159166 0.00355606170878243 NA NA NA hsa-miR-335-5p PIK3CA 1.59953351087307 5.56170899867314e-05 0.181162005416898 0.379919524282219 miRNAWalker2_validate -0.142668444274705 6.55217134166698e-05 NA NA NA hsa-miR-338-5p PIK3CA -1.19659203838734 0.0100316010080496 0.181162005416898 0.379919524282219 mirMAP -0.128160056012068 3.12181075963217e-05 NA NA NA hsa-miR-501-5p PIK3CA 0.266919328110625 0.454779001968586 0.181162005416898 0.379919524282219 mirMAP -0.184484665922465 4.78508048904086e-06 NA NA NA hsa-miR-7-1-3p PIK3CA 0.709309110750947 0.0412301737463194 0.181162005416898 0.379919524282219 mirMAP -0.18347710340594 9.07765701687707e-06 NA NA NA hsa-miR-130a-3p PIK3CB 0.146223920674657 0.633739795905839 0.248944033508746 0.180378115579181 miRNATAP -0.141347568269357 0.0010035949231668 NA NA NA hsa-miR-1468-5p PIK3CD -1.88350218312373 3.31332405201189e-05 0.391814669139483 0.253077445924908 MirTarget -0.217696918010317 3.06934786857079e-05 NA NA NA hsa-miR-30b-3p PIK3CD -0.266398938200332 0.400847813143994 0.391814669139483 0.253077445924908 MirTarget -0.431008741394064 8.57729594514163e-09 NA NA NA hsa-miR-30b-5p PIK3CD -0.430720743745757 0.0593564057320791 0.391814669139483 0.253077445924908 MirTarget -0.481822586915696 5.93876910377637e-06 NA NA NA hsa-miR-30d-5p PIK3CD -0.5492586056147 0.0140125082460125 0.391814669139483 0.253077445924908 MirTarget;miRNATAP -0.669349357920634 2.53796175626459e-10 NA NA NA hsa-miR-616-5p PIK3CD 0.834052908652744 0.0347835664029363 0.391814669139483 0.253077445924908 MirTarget -0.171408745877689 0.0062816347712319 NA NA NA hsa-miR-7-5p PIK3CD 1.63575693499363 0.0124424214624534 0.391814669139483 0.253077445924908 miRTarBase;MirTarget;miRNATAP -0.205801781586893 4.40558507915807e-08 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-103a-3p PIK3R1 0.840525139266028 5.83536475789158e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.323457232113071 0.0039447769693221 NA NA NA hsa-miR-106b-5p PIK3R1 1.70863907461894 2.04074794107142e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.253346436583178 1.72729352701852e-05 NA NA NA hsa-miR-107 PIK3R1 0.904627575346218 4.67936495073904e-05 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.238654922729134 0.0046938788179217 NA NA NA hsa-miR-128-3p PIK3R1 0.98280381420517 5.77641850797209e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.253825409257793 0.000861541031670611 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-144-3p PIK3R1 -0.13309578176575 0.798245647923351 -1.09428616452248 2.46783518047221e-05 mirMAP -0.138673461850839 0.000126186382128809 NA NA NA hsa-miR-15b-5p PIK3R1 1.62046407540723 5.42152621571078e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.323211150072369 4.46298725379362e-07 NA NA NA hsa-miR-16-2-3p PIK3R1 1.8048179609245 2.83095715136409e-09 -1.09428616452248 2.46783518047221e-05 MirTarget -0.270383492169966 3.99207467881518e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.00515772948091 5.33912942007619e-06 -1.09428616452248 2.46783518047221e-05 MirTarget -0.405416526556489 9.69480909855754e-07 NA NA NA hsa-miR-17-5p PIK3R1 1.65862087862483 8.45603406215941e-08 -1.09428616452248 2.46783518047221e-05 MirTarget;TargetScan;miRNATAP -0.192199170444737 0.00107429271534319 NA NA NA hsa-miR-182-5p PIK3R1 0.887369486030646 0.0310640781418789 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.160218491940506 0.000398426335382569 NA NA NA hsa-miR-185-5p PIK3R1 1.14351510556643 1.07346945085714e-08 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.41775889137189 4.21636400438791e-06 NA NA NA hsa-miR-188-5p PIK3R1 1.35426907033843 0.00038346077691455 -1.09428616452248 2.46783518047221e-05 MirTarget -0.162900447887926 0.000775923703794411 NA NA NA hsa-miR-200b-3p PIK3R1 0.974577911407732 0.0595020056914543 -1.09428616452248 2.46783518047221e-05 mirMAP -0.103803538669649 0.00409847558383849 NA NA NA hsa-miR-200c-3p PIK3R1 1.28185685499076 0.00369777635539177 -1.09428616452248 2.46783518047221e-05 mirMAP -0.143316221972735 0.00063899158230993 NA NA NA hsa-miR-20a-5p PIK3R1 1.4503375861709 5.7813456424762e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;miRNATAP -0.175478538743826 0.0056099063555159 NA NA NA hsa-miR-21-5p PIK3R1 1.75445050487988 2.41825549682022e-23 -1.09428616452248 2.46783518047221e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.306402457018565 0.00154965993784699 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.960352937108106 0.00133449812322732 -1.09428616452248 2.46783518047221e-05 MirTarget -0.22956448368642 0.000224776230276284 NA NA NA hsa-miR-22-5p PIK3R1 0.804348748654247 0.000804065112767412 -1.09428616452248 2.46783518047221e-05 mirMAP -0.271562984507077 0.000499671844853285 NA NA NA hsa-miR-221-3p PIK3R1 1.33496247538338 3.82022531235275e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.313499877783358 5.35467630228685e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.39382731585819 9.98182478024671e-07 -1.09428616452248 2.46783518047221e-05 MirTarget -0.284754511073413 7.61572703183408e-06 NA NA NA hsa-miR-3065-5p PIK3R1 -0.241623656423063 0.633116553078159 -1.09428616452248 2.46783518047221e-05 MirTarget;mirMAP;miRNATAP -0.124182539774803 0.00105993614946939 NA NA NA hsa-miR-32-3p PIK3R1 0.583525764322974 0.11837203008551 -1.09428616452248 2.46783518047221e-05 mirMAP -0.17265888879632 0.00228085828010069 NA NA NA hsa-miR-320b PIK3R1 1.11183660885284 0.000497971211648503 -1.09428616452248 2.46783518047221e-05 miRNATAP -0.162259703959997 0.00544641812773208 NA NA NA hsa-miR-324-3p PIK3R1 1.04940352369965 0.000387716796520961 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.184232658949902 0.00347746569584922 NA NA NA hsa-miR-330-3p PIK3R1 0.798460296022179 0.00746538156533435 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.26440540068663 2.08637052595379e-05 NA NA NA hsa-miR-335-3p PIK3R1 2.5197689063267 2.20084506976733e-09 -1.09428616452248 2.46783518047221e-05 mirMAP -0.148076206465714 0.000495756694433814 NA NA NA hsa-miR-424-5p PIK3R1 1.08509868581983 0.000420473853818268 -1.09428616452248 2.46783518047221e-05 MirTarget -0.287369315123124 1.32105570633977e-06 NA NA NA hsa-miR-429 PIK3R1 1.40182602301928 0.00900426780286475 -1.09428616452248 2.46783518047221e-05 mirMAP;miRNATAP -0.126994249956039 0.00022771493817442 NA NA NA hsa-miR-455-3p PIK3R1 2.29532323519288 1.85675588946527e-07 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRNATAP -0.181586331748295 8.05157474846207e-06 NA NA NA hsa-miR-542-3p PIK3R1 0.757649022262991 0.00210575463285599 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda -0.239065351988831 0.0017318237826115 NA NA NA hsa-miR-584-5p PIK3R1 1.68234626630933 0.000166828539264215 -1.09428616452248 2.46783518047221e-05 mirMAP -0.129450210806705 0.00170622715972499 NA NA NA hsa-miR-590-3p PIK3R1 1.11654983899947 0.000160782154924864 -1.09428616452248 2.46783518047221e-05 miRanda;mirMAP -0.266046553887174 1.8351581859886e-05 NA NA NA hsa-miR-590-5p PIK3R1 1.04171442093217 0.000272475544954865 -1.09428616452248 2.46783518047221e-05 MirTarget;PITA;miRanda;miRNATAP -0.297910761408884 3.33366270664506e-06 NA NA NA hsa-miR-629-3p PIK3R1 1.40326397107309 9.7803063526732e-05 -1.09428616452248 2.46783518047221e-05 MirTarget -0.16619442916244 0.00118253063445621 NA NA NA hsa-miR-96-5p PIK3R1 1.14243043653372 0.00942969392739105 -1.09428616452248 2.46783518047221e-05 TargetScan;miRNATAP -0.193630203103858 1.00718533638407e-05 NA NA NA hsa-miR-30a-5p PIK3R2 -1.71922855140016 3.20574349285256e-07 0.00922907299312037 0.961081205853821 miRNATAP -0.137164224996737 0.000346855164996688 NA NA NA hsa-miR-1271-5p PIK3R3 1.15538250415776 0.00207865862606828 -0.662491536689023 0.0210304127874503 mirMAP -0.197799197361284 0.00028487328401707 NA NA NA hsa-miR-185-3p PIK3R3 1.33711019171256 3.45756583967985e-05 -0.662491536689023 0.0210304127874503 MirTarget -0.200301326896551 0.00130353125166929 NA NA NA hsa-miR-511-5p PIK3R3 0.542335183701817 0.127507740178883 -0.662491536689023 0.0210304127874503 MirTarget -0.231823970894027 4.82261601939889e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-708-3p PIK3R3 0.623782703831307 0.275355868302311 -0.662491536689023 0.0210304127874503 mirMAP -0.147502347303041 2.93933869168246e-05 NA NA NA hsa-miR-182-5p PIK3R5 0.887369486030646 0.0310640781418789 -0.106061319644644 0.802628610118832 MirTarget -0.363007599134275 3.56264538888151e-07 NA NA NA hsa-miR-18a-3p PIK3R5 2.35188582849667 1.39401350286321e-08 -0.106061319644644 0.802628610118832 MirTarget -0.215221108190999 0.00210782353217643 NA NA NA hsa-miR-130a-3p PRKAA1 0.146223920674657 0.633739795905839 -0.11031844984051 0.603484784278822 MirTarget;miRNATAP -0.149554065669798 0.00237515644979475 NA NA NA hsa-miR-146b-3p PRKAA1 1.10138643500522 3.66835580263893e-05 -0.11031844984051 0.603484784278822 MirTarget;PITA;miRNATAP -0.159880575940438 0.0040852630528234 NA NA NA hsa-miR-152-3p PRKAA1 0.436002345388935 0.161701199884702 -0.11031844984051 0.603484784278822 MirTarget -0.188594057880005 8.42182092122934e-05 NA NA NA hsa-miR-224-3p PRKAA1 1.52422171450716 0.00650463542340912 -0.11031844984051 0.603484784278822 MirTarget -0.107509894610809 0.000196654827670158 NA NA NA hsa-miR-769-5p PRKAA1 1.14821899306381 1.27143750879772e-06 -0.11031844984051 0.603484784278822 MirTarget;PITA -0.256209603953874 3.30523424266437e-05 NA NA NA hsa-let-7d-5p PRKAA2 0.981733854788227 7.26366577706469e-07 -3.71133264004618 3.9299607177825e-05 MirTarget -1.20061764900106 0.000235472800470893 NA NA NA hsa-let-7f-1-3p PRKAA2 1.28704406797397 1.17954701106157e-06 -3.71133264004618 3.9299607177825e-05 mirMAP -1.12161744228138 2.63421941652295e-06 NA NA NA hsa-miR-106b-5p PRKAA2 1.70863907461894 2.04074794107142e-08 -3.71133264004618 3.9299607177825e-05 mirMAP -0.590927081903682 0.00458457271848234 NA NA NA hsa-miR-130b-3p PRKAA2 1.32714007211004 4.78676252285191e-05 -3.71133264004618 3.9299607177825e-05 MirTarget -0.636862993307953 0.00125092207613592 NA NA NA hsa-miR-142-5p PRKAA2 1.55592486377018 6.69269968016779e-06 -3.71133264004618 3.9299607177825e-05 mirMAP -0.484634735754829 0.0092541578176505 NA NA NA hsa-miR-146a-5p PRKAA2 1.82051649415508 2.03651725047679e-05 -3.71133264004618 3.9299607177825e-05 MirTarget -0.463601412715785 0.0019909428683854 NA NA NA hsa-miR-15b-3p PRKAA2 1.75738933306437 3.00554466232543e-08 -3.71133264004618 3.9299607177825e-05 mirMAP -0.613642846589506 0.00214003644966405 NA NA NA hsa-miR-16-2-3p PRKAA2 1.8048179609245 2.83095715136409e-09 -3.71133264004618 3.9299607177825e-05 mirMAP -0.725490763387464 0.000454424919074799 NA NA NA hsa-miR-17-5p PRKAA2 1.65862087862483 8.45603406215941e-08 -3.71133264004618 3.9299607177825e-05 mirMAP -0.727347652973957 0.000376279663801 NA NA NA hsa-miR-192-5p PRKAA2 0.0809146624034405 0.941057093528709 -3.71133264004618 3.9299607177825e-05 miRNAWalker2_validate -0.263647438903586 7.30199851190626e-06 NA NA NA hsa-miR-19a-3p PRKAA2 1.26669687448473 0.000105972838514412 -3.71133264004618 3.9299607177825e-05 mirMAP -0.616671439740848 0.00181244727354879 NA NA NA hsa-miR-20a-5p PRKAA2 1.4503375861709 5.7813456424762e-07 -3.71133264004618 3.9299607177825e-05 mirMAP -0.742762614304113 0.000734108936016583 NA NA NA hsa-miR-21-3p PRKAA2 1.75245546017565 2.36505176715025e-10 -3.71133264004618 3.9299607177825e-05 mirMAP -0.916372354505537 4.71091423087025e-05 NA NA NA hsa-miR-31-5p PRKAA2 0.666358292391859 0.381800494600846 -3.71133264004618 3.9299607177825e-05 MirTarget -0.254933092386802 0.00482998804925364 NA NA NA hsa-miR-323b-3p PRKAA2 1.13581624461921 0.0214847831286342 -3.71133264004618 3.9299607177825e-05 mirMAP -0.385332397863294 0.00992531661617914 NA NA NA hsa-miR-335-3p PRKAA2 2.5197689063267 2.20084506976733e-09 -3.71133264004618 3.9299607177825e-05 MirTarget -0.588326292668759 6.72977735836248e-05 NA NA NA hsa-miR-454-3p PRKAA2 0.625199142970745 0.0134890997402741 -3.71133264004618 3.9299607177825e-05 MirTarget -0.675421456170318 0.00970280004126242 NA NA NA hsa-miR-577 PRKAA2 0.911619788986754 0.2256062124148 -3.71133264004618 3.9299607177825e-05 MirTarget;PITA;miRNATAP -0.312455257440675 0.000411707891810278 NA NA NA hsa-miR-589-5p PRKAA2 0.702695092403762 0.00395772685954799 -3.71133264004618 3.9299607177825e-05 MirTarget -1.03409607920384 0.000112480768745506 NA NA NA hsa-miR-7-1-3p PRKAA2 0.709309110750947 0.0412301737463194 -3.71133264004618 3.9299607177825e-05 MirTarget;mirMAP -0.633679071955952 0.000743449889302512 NA NA NA hsa-miR-338-5p RHEB -1.19659203838734 0.0100316010080496 0.477054881122191 0.0131210521713065 MirTarget;PITA;miRNATAP -0.117522618826603 4.73448667777109e-05 NA NA NA hsa-miR-335-5p RICTOR 1.59953351087307 5.56170899867314e-05 0.0703417318616335 0.74825347385483 miRNAWalker2_validate -0.112993713853597 0.00318868765473778 NA NA NA hsa-miR-33a-3p RICTOR 0.347011402017138 0.321709379745392 0.0703417318616335 0.74825347385483 MirTarget;mirMAP -0.159655849852981 0.00059974244529564 NA NA NA hsa-miR-125b-5p RPS6KA1 -0.509303501421334 0.133265526313161 0.731929498307813 0.00274490008057769 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.234526493366172 3.98094595496741e-06 NA NA NA hsa-miR-1271-5p RPS6KA2 1.15538250415776 0.00207865862606828 -1.32620092187925 2.65708033500017e-05 mirMAP -0.250754934912831 3.52487370999946e-05 NA NA NA hsa-miR-17-5p RPS6KA2 1.65862087862483 8.45603406215941e-08 -1.32620092187925 2.65708033500017e-05 TargetScan -0.277422161233165 9.72880459807237e-05 NA NA NA hsa-miR-185-3p RPS6KA2 1.33711019171256 3.45756583967985e-05 -1.32620092187925 2.65708033500017e-05 MirTarget -0.240253769790685 0.000545054552010221 NA NA NA hsa-miR-193a-3p RPS6KA2 0.214911823818578 0.399323056245552 -1.32620092187925 2.65708033500017e-05 mirMAP -0.26491153991581 0.00356573319385792 NA NA NA hsa-miR-193b-3p RPS6KA2 0.281752012268679 0.451258902263119 -1.32620092187925 2.65708033500017e-05 mirMAP -0.384306076520259 6.13728537538736e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 1.28185685499076 0.00369777635539177 -1.32620092187925 2.65708033500017e-05 miRNATAP -0.150094253971244 0.00345925344024124 NA NA NA hsa-miR-3065-5p RPS6KA2 -0.241623656423063 0.633116553078159 -1.32620092187925 2.65708033500017e-05 mirMAP -0.150030422411658 0.00116928469807079 NA NA NA hsa-miR-9-3p RPS6KA2 0.330346058941473 0.541111939982661 -1.32620092187925 2.65708033500017e-05 MirTarget -0.154999756788344 0.000413323743564195 NA NA NA hsa-miR-9-5p RPS6KA2 -0.195328736653048 0.761470692992178 -1.32620092187925 2.65708033500017e-05 miRNATAP -0.141211407273439 5.87920360984724e-05 NA NA NA hsa-miR-93-3p RPS6KA2 1.88964231421793 1.80075645722786e-08 -1.32620092187925 2.65708033500017e-05 MirTarget -0.214747999929332 0.00107758815639912 NA NA NA hsa-let-7b-5p RPS6KA3 0.0582902155815681 0.781400138984745 0.346210158747265 0.0773954948531251 miRNATAP -0.285029367054611 1.95742569529439e-05 NA NA NA hsa-miR-218-5p RPS6KA3 -0.987730614742492 0.0108295837207062 0.346210158747265 0.0773954948531251 miRNATAP -0.179036217251255 2.72800797735199e-07 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-23a-3p RPS6KA3 1.10685926969665 3.16223452471768e-08 0.346210158747265 0.0773954948531251 mirMAP -0.275185887578108 4.74570150183976e-05 NA NA NA hsa-miR-23b-3p RPS6KA3 -0.286465516491361 0.18664668472995 0.346210158747265 0.0773954948531251 mirMAP -0.21401921753921 0.000992707720998224 NA NA NA hsa-miR-452-5p RPS6KA3 2.08756506185889 0.000258095769002813 0.346210158747265 0.0773954948531251 MirTarget;miRNATAP -0.115013851222988 8.80272333036024e-07 NA NA NA hsa-miR-141-3p RPS6KA6 1.45548825076434 0.00115958850961764 -5.00656872637833 4.11367694853314e-08 MirTarget -0.432468412213307 0.00360066422363021 NA NA NA hsa-miR-15a-5p RPS6KA6 1.03783090449383 7.40334108980898e-07 -5.00656872637833 4.11367694853314e-08 MirTarget -1.16712662892975 0.00022335981484185 NA NA NA hsa-miR-15b-5p RPS6KA6 1.62046407540723 5.42152621571078e-09 -5.00656872637833 4.11367694853314e-08 MirTarget -0.98737211999724 2.04686725019938e-05 NA NA NA hsa-miR-16-5p RPS6KA6 1.00515772948091 5.33912942007619e-06 -5.00656872637833 4.11367694853314e-08 MirTarget -1.17701610928795 8.80963847530128e-05 NA NA NA hsa-miR-17-5p RPS6KA6 1.65862087862483 8.45603406215941e-08 -5.00656872637833 4.11367694853314e-08 TargetScan -0.713815384598966 0.000699085878061688 NA NA NA hsa-miR-192-3p RPS6KA6 0.355565421687399 0.74117031340037 -5.00656872637833 4.11367694853314e-08 MirTarget -0.232226536686706 0.000226000863637598 NA NA NA hsa-miR-19a-3p RPS6KA6 1.26669687448473 0.000105972838514412 -5.00656872637833 4.11367694853314e-08 MirTarget -0.567774439590388 0.00532420547949485 NA NA NA hsa-miR-200a-3p RPS6KA6 0.717826667295984 0.193912116506827 -5.00656872637833 4.11367694853314e-08 MirTarget -0.3689692935826 0.0023827310098926 NA NA NA hsa-miR-335-3p RPS6KA6 2.5197689063267 2.20084506976733e-09 -5.00656872637833 4.11367694853314e-08 MirTarget -0.564882086576197 0.000205160896527142 NA NA NA hsa-miR-3662 RPS6KA6 1.82780708047676 0.0054036501346178 -5.00656872637833 4.11367694853314e-08 MirTarget -0.346660780011316 0.00849258086056814 NA NA NA hsa-miR-532-5p RPS6KA6 0.313080805824184 0.252248939356301 -5.00656872637833 4.11367694853314e-08 MirTarget;PITA;miRNATAP -0.858116720632928 0.00052951971496949 NA NA NA hsa-miR-340-5p RPS6KB1 -0.164941927483643 0.529910509321278 -0.0504582113908647 0.727179436430059 mirMAP -0.120667175252136 0.00197996146589472 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.878090699011564 0.000213630844319685 0.0265769630099237 0.903529405946182 miRanda -0.224677803871747 0.000539507740183902 NA NA NA hsa-miR-20a-5p STK11 1.4503375861709 5.7813456424762e-07 -0.203298821557102 0.29062016181051 MirTarget -0.12578955834794 0.00604542229657804 NA NA NA hsa-miR-23a-3p TSC1 1.10685926969665 3.16223452471768e-08 -0.564690517834756 7.84053178401563e-05 mirMAP -0.239924332441061 1.17024444416688e-06 NA NA NA hsa-miR-106b-5p ULK1 1.70863907461894 2.04074794107142e-08 -0.595487533514275 0.0157058826831611 miRNATAP -0.161797664501279 0.00376784935586512 NA NA NA hsa-miR-142-5p ULK1 1.55592486377018 6.69269968016779e-06 -0.595487533514275 0.0157058826831611 PITA;miRNATAP -0.138653188742566 0.00541680643943245 NA NA NA hsa-miR-148b-5p ULK1 1.04409494910362 0.00195860954157389 -0.595487533514275 0.0157058826831611 mirMAP -0.143061675881908 0.00576564648186122 NA NA NA hsa-miR-17-5p ULK1 1.65862087862483 8.45603406215941e-08 -0.595487533514275 0.0157058826831611 TargetScan;miRNATAP -0.155156635139728 0.00491115118178925 NA NA NA hsa-miR-186-5p ULK1 0.149964130725901 0.434709542998771 -0.595487533514275 0.0157058826831611 miRNAWalker2_validate -0.321950531551196 0.000586668470924891 NA NA NA hsa-miR-19a-3p ULK1 1.26669687448473 0.000105972838514412 -0.595487533514275 0.0157058826831611 mirMAP -0.159200216946591 0.00268729357367134 NA NA NA hsa-miR-20a-5p ULK1 1.4503375861709 5.7813456424762e-07 -0.595487533514275 0.0157058826831611 miRNATAP -0.185496107294068 0.00169219506974042 NA NA NA hsa-miR-32-5p ULK1 0.415247682945382 0.106458022460373 -0.595487533514275 0.0157058826831611 miRNATAP -0.220456431433876 0.00135968321296244 NA NA NA hsa-miR-320a ULK1 0.593888711838028 0.011897419390526 -0.595487533514275 0.0157058826831611 miRNAWalker2_validate;miRNATAP -0.305611067648794 3.83442773850333e-05 NA NA NA hsa-miR-320b ULK1 1.11183660885284 0.000497971211648503 -0.595487533514275 0.0157058826831611 miRNATAP -0.21727824817802 5.74251651646356e-05 NA NA NA hsa-miR-320c ULK1 0.455072851945474 0.240613785444485 -0.595487533514275 0.0157058826831611 miRNATAP -0.183643928893627 0.000448897262654572 NA NA NA hsa-miR-330-3p ULK1 0.798460296022179 0.00746538156533435 -0.595487533514275 0.0157058826831611 mirMAP -0.187004024822318 0.00144505128205032 NA NA NA hsa-miR-335-5p ULK1 1.59953351087307 5.56170899867314e-05 -0.595487533514275 0.0157058826831611 miRNAWalker2_validate -0.214685187072445 4.52888536745993e-07 NA NA NA hsa-miR-338-5p ULK1 -1.19659203838734 0.0100316010080496 -0.595487533514275 0.0157058826831611 PITA -0.17443115545205 2.20744121712284e-06 NA NA NA hsa-miR-423-5p ULK1 0.832613878736338 0.000791321227103338 -0.595487533514275 0.0157058826831611 miRNAWalker2_validate -0.332903648286363 1.67446788757599e-06 NA NA NA hsa-let-7f-1-3p ULK2 1.28704406797397 1.17954701106157e-06 -0.907082415689481 0.00236624733984012 MirTarget -0.250357911014318 0.00156076308912417 NA NA NA hsa-let-7g-5p ULK2 0.325297685027927 0.241142963826631 -0.907082415689481 0.00236624733984012 MirTarget -0.278878509153901 0.000310500591992077 NA NA NA hsa-miR-1266-5p ULK2 0.214881660714884 0.741561405223711 -0.907082415689481 0.00236624733984012 MirTarget -0.21206390859627 2.31803527337531e-11 NA NA NA hsa-miR-141-3p ULK2 1.45548825076434 0.00115958850961764 -0.907082415689481 0.00236624733984012 MirTarget;TargetScan -0.179004747302625 0.000130635497785837 NA NA NA hsa-miR-186-5p ULK2 0.149964130725901 0.434709542998771 -0.907082415689481 0.00236624733984012 MirTarget -0.327378046526938 0.00427219086199453 NA NA NA hsa-miR-200a-3p ULK2 0.717826667295984 0.193912116506827 -0.907082415689481 0.00236624733984012 MirTarget -0.201464058469131 8.52491323930372e-08 NA NA NA hsa-miR-200b-3p ULK2 0.974577911407732 0.0595020056914543 -0.907082415689481 0.00236624733984012 MirTarget;TargetScan -0.220564000061356 3.5987011383552e-08 NA NA NA hsa-miR-200c-3p ULK2 1.28185685499076 0.00369777635539177 -0.907082415689481 0.00236624733984012 MirTarget -0.175547088545099 0.00023168435550836 NA NA NA hsa-miR-223-3p ULK2 1.14371897083011 0.00455254073613731 -0.907082415689481 0.00236624733984012 MirTarget -0.179157277650137 0.000635055263609477 NA NA NA hsa-miR-335-5p ULK2 1.59953351087307 5.56170899867314e-05 -0.907082415689481 0.00236624733984012 miRNAWalker2_validate -0.235814832833896 6.11644557348375e-06 NA NA NA hsa-miR-3614-3p ULK2 0.816988052098069 0.0143572924352078 -0.907082415689481 0.00236624733984012 miRNATAP -0.252874123015422 0.000122503161374094 NA NA NA hsa-miR-429 ULK2 1.40182602301928 0.00900426780286475 -0.907082415689481 0.00236624733984012 MirTarget;PITA;miRanda;miRNATAP -0.21282195441811 2.94902482787402e-08 NA NA NA hsa-miR-577 ULK2 0.911619788986754 0.2256062124148 -0.907082415689481 0.00236624733984012 MirTarget;PITA;miRNATAP -0.182012189182628 5.6543172138364e-11 NA NA NA hsa-miR-582-5p ULK2 -0.448820171762719 0.134615974001015 -0.907082415689481 0.00236624733984012 miRNATAP -0.19635508188791 0.00624890342404261 NA NA NA hsa-miR-590-3p ULK2 1.11654983899947 0.000160782154924864 -0.907082415689481 0.00236624733984012 mirMAP -0.187724177453688 0.00890923238229461 NA NA NA hsa-miR-7-1-3p ULK2 0.709309110750947 0.0412301737463194 -0.907082415689481 0.00236624733984012 MirTarget;mirMAP -0.364607884087566 7.78212744494819e-10 NA NA NA hsa-miR-125a-5p ULK3 -0.878090699011564 0.000213630844319685 -0.104063218557225 0.630681667689949 PITA -0.213383352078453 0.000884453125965304 NA NA NA hsa-miR-1-3p VEGFA -2.66410453456934 1.50620580537836e-05 0.409900110754973 0.180026099055787 MirTarget -0.176948917904965 1.45151759893735e-07 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA -0.451263906815861 0.0283387250173031 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.335417986089274 0.00174980396829274 NA NA NA hsa-miR-129-5p VEGFA -2.56914016541176 2.36237896095709e-06 0.409900110754973 0.180026099055787 miRanda -0.105947559794297 0.00736909643879352 NA NA NA hsa-miR-133a-3p VEGFA -3.07408796787523 8.17423849601445e-07 0.409900110754973 0.180026099055787 miRNAWalker2_validate -0.162820736618245 8.37210469369392e-07 NA NA NA hsa-miR-145-5p VEGFA -1.75133578902314 1.54965572197748e-05 0.409900110754973 0.180026099055787 miRNAWalker2_validate;miRTarBase -0.220438811665314 2.09241456816908e-05 24781864;24966896;22472569 Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically metastasis;; thyroid cancer;bladder cancer;sarcoma hsa-miR-199a-5p VEGFA 0.371973504507027 0.232661597228763 0.409900110754973 0.180026099055787 miRanda;miRNATAP -0.211547585175076 0.00251514147236996 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-128-3p VEGFC 0.98280381420517 5.77641850797209e-05 0.195788328347819 0.656066637612163 miRNAWalker2_validate;MirTarget -0.546088637678822 1.30628253642657e-05 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC 1.8048179609245 2.83095715136409e-09 0.195788328347819 0.656066637612163 MirTarget -0.260465880829614 0.00866041293845893 NA NA NA hsa-miR-3662 VEGFC 1.82780708047676 0.0054036501346178 0.195788328347819 0.656066637612163 MirTarget -0.187356869827338 0.00206421517630613 NA NA NA