miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-141-3p ACADSB -0.354316381352484 0.256996894288799 -2.10604065735705 5.36295714659088e-25 MirTarget -0.109036278868871 0.00127149490738968 NA NA NA hsa-miR-141-3p ACO1 -0.354316381352484 0.256996894288799 -0.901613172142564 1.72939371106116e-12 MirTarget;TargetScan -0.11812325828284 4.99631258765398e-09 NA NA NA hsa-miR-141-3p ADRB1 -0.354316381352484 0.256996894288799 -2.23039514561495 1.86893298412028e-12 TargetScan -0.152105795267238 0.00280308139957717 NA NA NA hsa-miR-141-3p APOH -0.354316381352484 0.256996894288799 -1.62556911262229 6.75044201465841e-07 TargetScan -0.20680886473982 6.13589575874121e-05 NA NA NA hsa-miR-141-3p APOLD1 -0.354316381352484 0.256996894288799 0.453740241904891 0.00928610512501684 TargetScan -0.141057560063783 1.77689812205817e-07 NA NA NA hsa-miR-141-3p AR -0.354316381352484 0.256996894288799 -2.65514434874701 6.79656050811819e-11 mirMAP -0.414738704972838 8.40087125475703e-11 26062412;22314666 miR 141 3p regulates the expression of androgen receptor by targeting its 3'UTR in prostate cancer LNCaP cells; After prostate cancer cell line LNCaP was transfected with miR-141-3p mimics expression levels of AR mRNA and protein in the LNCaP cells were detected by reverse transcription PCR and Western blotting respectively; The 3'untranslated regions 3'UTR of AR mRNA containing the binding site of miR-141-3p was amplified by PCR and inserted into pmiR-report vector a 3'downstream luciferase reporter gene; Transfection of miR-141-3p mimics decreased both mRNA and protein expression levels of AR in LNCaP cells; AR is a direct target gene of miR-141-3p;miR 141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein; Here we investigated the correlation of Shp expression with the cellular level of miR-141 and its effects on AR transcriptional activity in non-malignant and malignant human prostate epithelial cell lines; Phenethyl isothiocyanate a natural constituent of many edible cruciferous vegetables increased Shp expression downregulated miR-141 and inhibited AR transcriptional activity in LNCaP cells; Shp is a target for miR-141 and it is downregulated in cultured human PCa cells with the involvement of upregulation of miR-141 which promotes AR transcriptional activity ;malignant trasformation prostate cancer;prostate cancer hsa-miR-141-3p ATXN7L1 -0.354316381352484 0.256996894288799 -0.241046795006661 0.0606470141841609 TargetScan;miRNATAP -0.110518980840858 2.36297097676216e-08 NA NA NA hsa-miR-141-3p C1orf21 -0.354316381352484 0.256996894288799 -0.747097178874137 0.000448927531443378 TargetScan;miRNATAP -0.138457316457098 3.19610891872253e-05 NA NA NA hsa-miR-141-3p CADM1 -0.354316381352484 0.256996894288799 -0.0259171422650883 0.886286112596045 MirTarget;TargetScan -0.180942442557432 6.54309893297213e-11 NA NA NA hsa-miR-141-3p CDC14B -0.354316381352484 0.256996894288799 -1.18862488716786 6.19212759828214e-11 mirMAP -0.196426786345194 4.76704735431923e-12 NA NA NA hsa-miR-141-3p CDK6 -0.354316381352484 0.256996894288799 -0.306731100792328 0.220566158555725 TargetScan;miRNATAP -0.140574578703219 0.000314373241862064 NA NA NA hsa-miR-141-3p CELF6 -0.354316381352484 0.256996894288799 1.58856809226333 5.40027533112525e-12 TargetScan -0.138183810182478 0.000178013459584703 NA NA NA hsa-miR-141-3p CFL2 -0.354316381352484 0.256996894288799 -1.18046432826413 1.44423082204062e-19 TargetScan -0.148531413756853 9.39948066733766e-13 NA NA NA hsa-miR-141-3p CLYBL -0.354316381352484 0.256996894288799 -1.25097168648654 5.78163364095158e-13 mirMAP -0.165230671656148 1.8044364076505e-09 NA NA NA hsa-miR-141-3p CPEB3 -0.354316381352484 0.256996894288799 -2.73760799365771 6.08365930201296e-43 MirTarget -0.126164954945559 0.000262179184796228 NA NA NA hsa-miR-141-3p CPLX2 -0.354316381352484 0.256996894288799 5.16430096205473 2.83212867957316e-12 mirMAP -0.465422556423815 8.39298981973772e-05 NA NA NA hsa-miR-141-3p DDI2 -0.354316381352484 0.256996894288799 -1.53096229477393 2.81259482387215e-06 mirMAP -0.13244793064086 0.0105038048718545 NA NA NA hsa-miR-141-3p DYNC1I1 -0.354316381352484 0.256996894288799 1.66864494169359 1.46552904583527e-05 MirTarget -0.184168907436402 0.00244171632907993 NA NA NA hsa-miR-141-3p ELL2 -0.354316381352484 0.256996894288799 -0.765981836031949 3.63519932659754e-07 TargetScan -0.128217845359143 5.16043180184258e-08 NA NA NA hsa-miR-141-3p FAM169A -0.354316381352484 0.256996894288799 0.365458857393713 0.13290757956596 mirMAP -0.123632175352074 0.00112747018817934 NA NA NA hsa-miR-141-3p FKBP5 -0.354316381352484 0.256996894288799 -0.232073250029758 0.19420333201796 TargetScan -0.117882801878837 2.16645368001898e-05 NA NA NA hsa-miR-141-3p GFRA1 -0.354316381352484 0.256996894288799 -2.5486406119615 2.43457108723549e-08 mirMAP -0.255470507973721 0.00042646098794154 NA NA NA hsa-miR-141-3p GFRA2 -0.354316381352484 0.256996894288799 -1.04393868358313 2.62726967509854e-06 mirMAP -0.171178006711114 8.7751647727696e-07 NA NA NA hsa-miR-141-3p GLRX -0.354316381352484 0.256996894288799 -0.975673886303721 2.13364253566235e-08 MirTarget;TargetScan;miRNATAP -0.114945432530151 2.99453729420918e-05 NA NA NA hsa-miR-141-3p GNE -0.354316381352484 0.256996894288799 -1.82350791069008 3.50187061744317e-25 MirTarget -0.160829750931771 2.42749723875916e-08 NA NA NA hsa-miR-141-3p GNG7 -0.354316381352484 0.256996894288799 -0.344922469297116 0.0809202837414247 MirTarget;TargetScan;miRNATAP -0.142045092870118 3.59031496857192e-06 NA NA NA hsa-miR-141-3p GNPTG -0.354316381352484 0.256996894288799 0.0368571934199 0.718426542304522 TargetScan -0.10844425246299 2.93015703782576e-12 NA NA NA hsa-miR-141-3p GPAM -0.354316381352484 0.256996894288799 -0.472844151955403 0.0637965177079971 MirTarget -0.103023927857149 0.00990547714436476 NA NA NA hsa-miR-141-3p GPD1 -0.354316381352484 0.256996894288799 -2.61322405001312 1.93177757503586e-15 TargetScan -0.174736503097449 0.00102747286407864 NA NA NA hsa-miR-141-3p GPHN -0.354316381352484 0.256996894288799 -1.45550998345727 2.04560906611985e-19 TargetScan;miRNATAP -0.162955799742008 3.36753859205138e-10 NA NA NA hsa-miR-141-3p HLF -0.354316381352484 0.256996894288799 -1.56359740264692 3.39928227602253e-08 TargetScan -0.306060107640014 3.41585126418407e-12 NA NA NA hsa-miR-141-3p HNMT -0.354316381352484 0.256996894288799 -0.66616359607371 8.7117069241868e-08 TargetScan -0.108723659748667 2.3241192720031e-08 NA NA NA hsa-miR-141-3p HOMER2 -0.354316381352484 0.256996894288799 -1.00582423350523 5.86664467329435e-05 mirMAP -0.122532141657208 0.001883237620167 NA NA NA hsa-miR-141-3p HS3ST3B1 -0.354316381352484 0.256996894288799 -2.60592423161066 9.57213132909845e-18 mirMAP -0.156241679988969 0.00159047869701333 NA NA NA hsa-miR-141-3p IL6R -0.354316381352484 0.256996894288799 -0.197357669964791 0.382548993653367 MirTarget -0.142554332435554 4.93408139054963e-05 NA NA NA hsa-miR-141-3p IRS2 -0.354316381352484 0.256996894288799 -0.811999517586244 8.14991854093828e-06 MirTarget;TargetScan;miRNATAP -0.157171635620505 2.97999889265583e-08 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2 metastasis thyroid cancer hsa-miR-141-3p IYD -0.354316381352484 0.256996894288799 -2.66179429977146 1.10383788101266e-13 mirMAP -0.158967996884554 0.00598917452121459 NA NA NA hsa-miR-141-3p KLF12 -0.354316381352484 0.256996894288799 -0.863221902725629 5.4142350807271e-09 MirTarget;TargetScan -0.131585175476837 1.44141694847702e-08 NA NA NA hsa-miR-141-3p KLHDC10 -0.354316381352484 0.256996894288799 -0.301845977708177 0.070704300321483 TargetScan -0.137857016159273 9.02373282137124e-08 NA NA NA hsa-miR-141-3p MFAP3L -0.354316381352484 0.256996894288799 -2.99511248620354 4.97173912475439e-19 MirTarget -0.168035444046643 0.00222808165270307 NA NA NA hsa-miR-141-3p MOCS2 -0.354316381352484 0.256996894288799 -0.169901491598204 0.110407637364637 TargetScan -0.134612247482911 3.86850830967459e-17 NA NA NA hsa-miR-141-3p MTSS1 -0.354316381352484 0.256996894288799 -0.158641289745661 0.2101510371787 TargetScan;miRNATAP -0.107045763357796 3.97566066593247e-08 NA NA NA hsa-miR-141-3p MYRIP -0.354316381352484 0.256996894288799 -1.62618818441801 1.98171502701597e-05 MirTarget;TargetScan -0.494611162123544 1.33263885170833e-17 NA NA NA hsa-miR-141-3p NFIA -0.354316381352484 0.256996894288799 -0.924685216157224 2.60745966247054e-13 TargetScan;miRNATAP -0.134523704359465 1.35605863608001e-11 NA NA NA hsa-miR-141-3p NUDT12 -0.354316381352484 0.256996894288799 -0.913123810950026 1.69707017169193e-05 MirTarget -0.18927750999078 9.84393597734858e-09 NA NA NA hsa-miR-141-3p NUDT16 -0.354316381352484 0.256996894288799 -0.306472623503673 0.00173007556301039 mirMAP -0.12219397699242 1.34047492761987e-16 NA NA NA hsa-miR-141-3p PDXP -0.354316381352484 0.256996894288799 -0.387609263302668 0.00374026023066805 TargetScan -0.115995852554092 1.96152015127879e-08 NA NA NA hsa-miR-141-3p PGRMC1 -0.354316381352484 0.256996894288799 -0.899011937853434 4.01593880771907e-09 TargetScan -0.164402418537406 4.54935473592493e-12 NA NA NA hsa-miR-141-3p PHLPP1 -0.354316381352484 0.256996894288799 -0.739355893829483 5.14182264498052e-09 MirTarget;TargetScan;miRNATAP -0.122856168863493 5.12037878302015e-10 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-141-3p PHYHIPL -0.354316381352484 0.256996894288799 0.875425421453594 0.00299276786748856 MirTarget;TargetScan;miRNATAP -0.113485054586549 0.0143537866929175 NA NA NA hsa-miR-141-3p PPARA -0.354316381352484 0.256996894288799 -0.607171871846345 3.30592576448713e-05 miRNAWalker2_validate;miRTarBase -0.122247389709584 7.84624637376833e-08 NA NA NA hsa-miR-141-3p PPP1R3G -0.354316381352484 0.256996894288799 -0.769934803923256 0.0336142915545988 TargetScan -0.197558903439126 0.000483411570485674 NA NA NA hsa-miR-141-3p RAD54L2 -0.354316381352484 0.256996894288799 -0.971014379311522 6.78213260971141e-06 TargetScan -0.104327960639769 0.00219256681648611 NA NA NA hsa-miR-141-3p RBM24 -0.354316381352484 0.256996894288799 1.89188345491287 3.06626255996883e-11 TargetScan -0.230004113099172 3.5307178159905e-07 NA NA NA hsa-miR-141-3p RNF217 -0.354316381352484 0.256996894288799 -0.867667786029885 3.07330761625567e-05 mirMAP -0.110284431781051 0.000763968702183623 NA NA NA hsa-miR-141-3p RORA -0.354316381352484 0.256996894288799 -1.18591701647076 1.08163415927424e-11 MirTarget;TargetScan;miRNATAP -0.116334079482372 2.91463202028021e-05 NA NA NA hsa-miR-141-3p RSPO2 -0.354316381352484 0.256996894288799 -1.47503442551075 0.000466618278395286 MirTarget -0.272394887123816 3.64046176387836e-05 NA NA NA hsa-miR-141-3p SCP2 -0.354316381352484 0.256996894288799 -1.70380219576361 1.44289672057111e-21 miRNATAP -0.150580326113915 2.23190963351792e-07 NA NA NA hsa-miR-141-3p SDC2 -0.354316381352484 0.256996894288799 -0.03087902282995 0.814769949243076 MirTarget;TargetScan -0.10983256005135 6.18806915807726e-08 NA NA NA hsa-miR-141-3p SERPINC1 -0.354316381352484 0.256996894288799 -1.63659372569249 4.45044096391072e-05 TargetScan -0.34284074618825 3.93713144365036e-08 NA NA NA hsa-miR-141-3p SFXN1 -0.354316381352484 0.256996894288799 -0.990318290801911 5.86324585320089e-17 TargetScan -0.123592817208737 5.17394174384046e-11 NA NA NA hsa-miR-141-3p SLC16A7 -0.354316381352484 0.256996894288799 -1.26418567420408 1.8151156622962e-05 MirTarget;TargetScan;miRNATAP -0.10392091978998 0.0258971789698889 NA NA NA hsa-miR-141-3p SLC1A1 -0.354316381352484 0.256996894288799 -2.48716408312787 1.83542966329299e-11 TargetScan;miRNATAP -0.122708932191503 0.0392433722519207 NA NA NA hsa-miR-141-3p SLC23A2 -0.354316381352484 0.256996894288799 -0.584703803315866 0.0010236404080005 TargetScan;miRNATAP -0.14335799786569 2.16511218871747e-07 NA NA NA hsa-miR-141-3p SLC25A42 -0.354316381352484 0.256996894288799 -0.835095118088987 2.88686387157856e-06 mirMAP -0.129267057209226 3.88471771806008e-06 NA NA NA hsa-miR-141-3p SLC30A1 -0.354316381352484 0.256996894288799 -1.21292412377968 4.55064472411421e-13 TargetScan -0.108211232924951 5.52796526006518e-05 NA NA NA hsa-miR-141-3p SORBS2 -0.354316381352484 0.256996894288799 -1.05178871500438 1.28000308624213e-08 MirTarget;TargetScan -0.127531510285571 1.27533890449428e-05 NA NA NA hsa-miR-141-3p SPPL2A -0.354316381352484 0.256996894288799 -0.156672403071684 0.108823480972017 TargetScan -0.101142947844604 1.09140592060499e-11 NA NA NA hsa-miR-141-3p SSTR1 -0.354316381352484 0.256996894288799 -1.62125065278544 7.93133709820033e-06 mirMAP -0.274621169500968 1.35598083088402e-06 NA NA NA hsa-miR-141-3p ST3GAL3 -0.354316381352484 0.256996894288799 0.0452353339861049 0.689737393298641 MirTarget;TargetScan;miRNATAP -0.135618598425992 2.07829722145825e-15 NA NA NA hsa-miR-141-3p TAPT1 -0.354316381352484 0.256996894288799 -1.13334263866931 3.16520734266326e-25 TargetScan -0.107621844224575 1.53719898815729e-09 NA NA NA hsa-miR-141-3p THRB -0.354316381352484 0.256996894288799 -0.630015828817221 1.00813020178641e-06 MirTarget;TargetScan;miRNATAP -0.101688963632654 4.56286813093783e-07 NA NA NA hsa-miR-141-3p TMEM192 -0.354316381352484 0.256996894288799 -1.02995452969358 8.50907462678487e-17 TargetScan -0.123352752191487 3.99136604841861e-10 NA NA NA hsa-miR-141-3p TMEM56 -0.354316381352484 0.256996894288799 -1.75634225549522 4.44536598470124e-19 MirTarget;TargetScan;miRNATAP -0.153532225688745 1.48644767278966e-06 NA NA NA hsa-miR-141-3p TTR -0.354316381352484 0.256996894288799 -2.49469648639749 2.55802246258903e-11 MirTarget;TargetScan;miRNATAP -0.203885752050389 0.000657556679065877 NA NA NA hsa-miR-141-3p UGT1A1 -0.354316381352484 0.256996894288799 -2.58200610381644 1.62684107925468e-09 TargetScan -0.311052891547131 4.47735823409309e-06 NA NA NA hsa-miR-141-3p UGT1A3 -0.354316381352484 0.256996894288799 -2.58217161395639 3.74628631264762e-07 MirTarget;TargetScan -0.455285471064215 9.90084953423558e-09 NA NA NA hsa-miR-141-3p UGT1A4 -0.354316381352484 0.256996894288799 -3.36385452578458 2.40497028381343e-09 MirTarget;TargetScan -0.555390156357305 3.119343536601e-10 NA NA NA hsa-miR-141-3p UGT1A5 -0.354316381352484 0.256996894288799 -2.23550242511071 7.76708335483891e-07 MirTarget;TargetScan -0.403111550607379 1.16609181243243e-08 NA NA NA hsa-miR-141-3p UGT1A6 -0.354316381352484 0.256996894288799 -1.15697185702361 0.00101741339358789 MirTarget;TargetScan -0.167246421495177 0.00249833490942057 NA NA NA hsa-miR-141-3p UGT1A9 -0.354316381352484 0.256996894288799 -1.3504570414494 0.000136466111152902 MirTarget;TargetScan -0.281158319073045 3.48653149744002e-07 NA NA NA hsa-miR-141-3p USH2A -0.354316381352484 0.256996894288799 -2.26734306551942 1.94801387719099e-11 MirTarget -0.153376473907424 0.00465849008022714 NA NA NA hsa-miR-141-3p WNK3 -0.354316381352484 0.256996894288799 -0.836532944570787 0.00785592148273515 mirMAP -0.18090888963671 0.000235491240988731 NA NA NA hsa-miR-141-3p ZBTB16 -0.354316381352484 0.256996894288799 -1.16865006982612 0.000104779212042064 TargetScan -0.283194079899083 1.28806541259836e-09 NA NA NA hsa-miR-141-3p ZCCHC24 -0.354316381352484 0.256996894288799 -1.09299525922251 5.15915193886857e-19 MirTarget;TargetScan;miRNATAP -0.115172394176129 5.29021951189563e-09 NA NA NA hsa-miR-141-3p ZFAND5 -0.354316381352484 0.256996894288799 -0.89687020061194 5.59442964172277e-08 TargetScan -0.109375556012044 2.72275947562615e-05 NA NA NA hsa-miR-141-3p ZNF385D -0.354316381352484 0.256996894288799 1.93039544568422 6.08448979085829e-06 MirTarget;TargetScan -0.282501804710065 2.54122459782692e-05 NA NA NA