miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125a-5p B2M 0.599529391575274 0.0102300147180307 -0.00374449202842086 0.988481900075066 miRanda -0.203707197913715 0.000146311442126184 NA NA NA hsa-miR-361-5p B2M 0.971859117235239 5.30236555707088e-09 -0.00374449202842086 0.988481900075066 miRanda -0.421102868852978 1.26901731111637e-08 NA NA NA hsa-miR-93-5p B2M 3.03961860136032 1.11672209617395e-24 -0.00374449202842086 0.988481900075066 miRNAWalker2_validate -0.234441907807927 2.3459189191316e-09 NA NA NA hsa-miR-532-3p BTK 1.96631878320218 4.53421954361695e-13 -1.40865588593221 0.00109126075148836 miRNATAP -0.470056410388284 1.91933217292442e-10 NA NA NA hsa-miR-590-3p BTK 2.59289455139753 1.03200520972022e-21 -1.40865588593221 0.00109126075148836 MirTarget;PITA;miRanda;miRNATAP -0.187091700951732 0.0137213140224691 NA NA NA hsa-miR-590-5p BTK 3.18300989862077 2.06813568597893e-26 -1.40865588593221 0.00109126075148836 miRanda -0.334711768013022 5.89359854191586e-07 NA NA NA hsa-miR-181a-5p CDC73 2.29556023480783 1.8138457900616e-21 -0.428384894562094 0.00223307522406707 miRNATAP -0.114701874292182 1.71749080682815e-05 NA NA NA hsa-miR-181c-5p CDC73 1.58587920618301 1.57506918816933e-10 -0.428384894562094 0.00223307522406707 miRNATAP -0.161768846573894 9.13823305059902e-10 NA NA NA hsa-miR-186-5p CDC73 1.47445398888668 3.0781726595413e-15 -0.428384894562094 0.00223307522406707 mirMAP -0.140493992879485 6.84370802857228e-05 NA NA NA hsa-miR-19b-3p CDC73 2.49529833021187 1.57028265846699e-23 -0.428384894562094 0.00223307522406707 miRNATAP -0.113971510798806 8.61695764302812e-06 NA NA NA hsa-miR-26a-5p CDC73 0.0464832722967259 0.752628386912329 -0.428384894562094 0.00223307522406707 MirTarget;mirMAP -0.117054852237626 0.0131017945998908 NA NA NA hsa-miR-26b-5p CDC73 0.885393662798425 3.2116297961629e-06 -0.428384894562094 0.00223307522406707 MirTarget;mirMAP -0.1120059952044 0.00167441188699504 NA NA NA hsa-miR-28-5p CDC73 0.230152919654905 0.0742909586754846 -0.428384894562094 0.00223307522406707 miRanda -0.214020598811231 7.47465944845484e-05 NA NA NA hsa-miR-30b-5p CDC73 0.800822374912712 0.000133601914525413 -0.428384894562094 0.00223307522406707 MirTarget;mirMAP -0.156560851185467 1.0750256701631e-06 NA NA NA hsa-miR-30c-5p CDC73 0.778774633108 0.000285599212429136 -0.428384894562094 0.00223307522406707 MirTarget;mirMAP -0.213753082769721 4.75310786974852e-12 NA NA NA hsa-miR-30d-3p CDC73 0.977747550180601 4.3048212205381e-05 -0.428384894562094 0.00223307522406707 MirTarget -0.102383173129326 0.000288704268230078 NA NA NA hsa-miR-30e-3p CDC73 -0.215663037684509 0.235375122783546 -0.428384894562094 0.00223307522406707 MirTarget -0.101198950261817 0.00752323210577884 NA NA NA hsa-miR-30e-5p CDC73 1.23904909539663 1.35561917122157e-09 -0.428384894562094 0.00223307522406707 MirTarget -0.176466004813769 5.13178224522802e-08 NA NA NA hsa-miR-362-3p CDC73 2.0756816987665 3.89026064579331e-12 -0.428384894562094 0.00223307522406707 miRNATAP -0.1152168200108 3.5466744121617e-07 NA NA NA hsa-miR-374a-5p CDC73 0.484615721953736 0.0042981729815149 -0.428384894562094 0.00223307522406707 mirMAP -0.145741183039853 0.000303936320795236 NA NA NA hsa-miR-374b-5p CDC73 0.0654362503857184 0.722673188879465 -0.428384894562094 0.00223307522406707 mirMAP;miRNATAP -0.113275848484712 0.00238013384404498 NA NA NA hsa-miR-454-3p CDC73 2.47234127820054 1.12878018736016e-21 -0.428384894562094 0.00223307522406707 miRNATAP -0.128058158578216 4.83985976068161e-07 NA NA NA hsa-miR-500a-5p CDC73 1.72110365584658 3.0807246212659e-10 -0.428384894562094 0.00223307522406707 mirMAP -0.113149356522622 2.86276658749816e-06 NA NA NA hsa-miR-664a-3p CDC73 0.634721925861133 0.00520070178640421 -0.428384894562094 0.00223307522406707 MirTarget -0.141658861425459 1.85373229033198e-06 NA NA NA hsa-miR-182-5p CDKN2C 3.53923166221814 5.07781258121574e-21 0.22688212352847 0.433133415352322 MirTarget -0.132415467904401 0.00017052034340074 NA NA NA hsa-miR-34a-5p CDKN2C 1.9016323452565 1.43092834643601e-14 0.22688212352847 0.433133415352322 miRNAWalker2_validate -0.218709270480303 6.47001667111707e-05 NA NA NA hsa-miR-25-3p CIC 1.36472605225697 4.83790725935681e-11 -0.161198374548771 0.158795112852919 miRNATAP -0.10777617438352 3.30726516012098e-05 NA NA NA hsa-miR-32-5p CIC 2.34056473219422 6.24134585974322e-20 -0.161198374548771 0.158795112852919 miRNATAP -0.100309091942242 8.54780985907079e-07 NA NA NA hsa-miR-423-5p CIC 0.963563145758616 9.86109015204915e-07 -0.161198374548771 0.158795112852919 miRNATAP -0.10398757090895 0.000181478434407827 NA NA NA hsa-miR-107 CSF1R 1.30977326593435 1.30372468603965e-11 -1.04722118455631 0.017969966085107 miRanda -0.894015814449865 2.03071082250236e-17 NA NA NA hsa-miR-339-5p CSF1R 2.68710938429893 3.03134080808154e-16 -1.04722118455631 0.017969966085107 miRanda -0.230136953690785 0.000242843989086468 NA NA NA hsa-miR-34a-5p CSF1R 1.9016323452565 1.43092834643601e-14 -1.04722118455631 0.017969966085107 MirTarget;miRNATAP -0.461603981922354 2.97565476458688e-08 NA NA NA hsa-miR-101-3p DCUN1D1 0.522819989585461 0.00375627731618038 0.0817078524559562 0.572753926231056 MirTarget -0.112906597670674 0.00384107202161282 NA NA NA hsa-miR-140-3p DCUN1D1 0.0608890720479334 0.727716871248724 0.0817078524559562 0.572753926231056 MirTarget;PITA -0.136077090381994 0.000772627267437124 NA NA NA hsa-miR-181a-5p DCUN1D1 2.29556023480783 1.8138457900616e-21 0.0817078524559562 0.572753926231056 MirTarget;mirMAP -0.105282717607679 0.000129719450181858 NA NA NA hsa-miR-218-5p DCUN1D1 -0.573801507392184 0.0551983860126703 0.0817078524559562 0.572753926231056 MirTarget -0.135714085228732 3.46584630606182e-09 27285984 An inverse correlation was observed between the expression of miR-218 and DCUN1D1 protein in cervical cancer tissues; Importantly HPV16 E6 downregulated the expression of miR-218 in cervical cancer while miR-218 rescued the promotion effect of HPV16 E6 on the expression of SFMBT1 and DCUN1D1; Taken together our results revealed that HPV16 E6 promoted EMT and invasion in cervical cancer via the repression of miR-218 while miR-218 inhibited EMT and invasion in cervical cancer by targeting SFMBT1 and DCUN1D1 cervical and endocervical cancer hsa-miR-21-5p DDR2 2.73773305747971 1.38864982139576e-43 -3.19296935408292 1.03810493961679e-10 miRNAWalker2_validate -0.331403169912738 0.00311398626573537 NA NA NA hsa-miR-330-3p DDR2 0.876747334239085 0.00073709016089703 -3.19296935408292 1.03810493961679e-10 miRNATAP -0.677654782363722 1.36397774850741e-13 NA NA NA hsa-miR-143-3p DNMT3A -2.5789192793377 1.55518999614836e-14 0.850793143902836 1.00169897998871e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.111773174433085 4.38845553262621e-06 19638978;24218337 Using in silico predictions DNA methyltranferase 3A DNMT3A was defined as a potential target of miR-143; Restoration of the miR-143 expression in colon cell lines decreased tumour cell growth and soft-agar colony formation and downregulated the DNMT3A expression in both mRNA and protein levels; DNMT3A was shown to be a direct target of miR-143 by luciferase reporter assay; Furthermore the miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in CRC tissues; Our findings suggest that miR-143 regulates DNMT3A in CRC;Ectopic expression of miR-143 inhibited proliferation and soft agar colony formation of breast cancer cells and also downregulated DNA methyltransferase 3A DNMT3A expression on both mRNA and protein levels; DNMT3A was demonstrated to be a direct target of miR-143 by luciferase reporter assay; Furthermore miR-143 expression was observed to be inversely correlated with DNMT3A mRNA and protein expression in breast cancer tissues; Our findings suggest that miR-143 regulates DNMT3A in breast cancer cells ; colorectal cancer;breast cancer hsa-miR-29a-3p DNMT3A -0.35074463683376 0.161238718982428 0.850793143902836 1.00169897998871e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.246775777007236 1.08111870391983e-13 26471361;23939044;24798303;25874772;17890317;22479643;25746661 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;Consistent with miR-29's role in targeting DNA methyltransferase 3A DNMT3A a key enzyme regulating DNA methylation we found a significant inverse correlation P<0.001 between miR-29 and DNMT3A gene expression suggesting that they might be functionally antagonistic; Overexpression of AFP or conditioned media from AFP+ cells inhibits miR-29a expression and induces DNMT3A expression in AFP- HCC cells;The de-regulation of the miR-29 family and DNA methyltransferase 3A DNMT3A is associated with gastric cancer GC;Among the reported down-regulated miRNAs in lung cancer the miRNA miR-29 family 29a 29b and 29c has intriguing complementarities to the 3'-UTRs of DNA methyltransferase DNMT3A and -3B de novo methyltransferases two key enzymes involved in DNA methylation that are frequently up-regulated in lung cancer and associated with poor prognosis;The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability;DNMT3A and 3B genes can be regulated post-transcriptionally by miR-29 family ;;;;worse prognosis;; bladder cancer;lung squamous cell cancer;liver cancer;gastric cancer;lung cancer;ovarian cancer;lymphoma hsa-miR-29a-5p DNMT3A 1.46749674755271 3.34605004270294e-07 0.850793143902836 1.00169897998871e-06 MirTarget -0.127302185177555 3.50767788522362e-05 26471361;23939044;24798303;25874772;17890317;22479643;25746661 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;Consistent with miR-29's role in targeting DNA methyltransferase 3A DNMT3A a key enzyme regulating DNA methylation we found a significant inverse correlation P<0.001 between miR-29 and DNMT3A gene expression suggesting that they might be functionally antagonistic; Overexpression of AFP or conditioned media from AFP+ cells inhibits miR-29a expression and induces DNMT3A expression in AFP- HCC cells;The de-regulation of the miR-29 family and DNA methyltransferase 3A DNMT3A is associated with gastric cancer GC;Among the reported down-regulated miRNAs in lung cancer the miRNA miR-29 family 29a 29b and 29c has intriguing complementarities to the 3'-UTRs of DNA methyltransferase DNMT3A and -3B de novo methyltransferases two key enzymes involved in DNA methylation that are frequently up-regulated in lung cancer and associated with poor prognosis;The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability;DNMT3A and 3B genes can be regulated post-transcriptionally by miR-29 family ;;;;worse prognosis;; bladder cancer;lung squamous cell cancer;liver cancer;gastric cancer;lung cancer;ovarian cancer;lymphoma hsa-miR-30a-5p DNMT3A -0.878357906436456 0.000509952992366057 0.850793143902836 1.00169897998871e-06 MirTarget;miRNATAP -0.140324734151611 2.68951330685574e-05 NA NA NA hsa-miR-145-5p DNMT3B -1.55259331973517 9.97889123247165e-07 2.42098752407681 1.03826481393344e-14 MirTarget -0.115996922206136 0.0175614622180234 24071015;25749421 In univariate analysis the combination of DNMT3B overexpression and miR-145 or miR-143 down-regulation was more powerful in predicting shorter survival P < .05 than use of the biomarkers individually P > .05; DNMT3B might be a potential target of miR-145 and miR-143 in ECs; Furthermore the combined miR-145 or miR-143 and DNMT3B status may have a prognostic impact on ECs;It was found that miR-145 upregulates while DNMT3b downregulates in PC3 cells; Responses of the miR-145 and DNMT3b to irradiation are a negative correlation; We also found that either overexpression of miR-145 or knockdown of DNMT3b sensitized prostate cancer cells to X-ray radiation poor survival;drug resistance endometrial cancer;prostate cancer hsa-miR-29a-3p DNMT3B -0.35074463683376 0.161238718982428 2.42098752407681 1.03826481393344e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.261231019524908 2.92895691773392e-05 23939044;23789939;22479643 The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;TGF-β increased DNMT3B and DNMT1 and decreased miR-29a expression;The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability ;; lung squamous cell cancer;liver cancer;ovarian cancer hsa-let-7c-5p DOT1L -2.07847142524506 5.51224567263294e-09 0.488977543723678 0.000977532113506735 miRNAWalker2_validate -0.102390108999426 1.68088023398746e-07 NA NA NA hsa-miR-361-5p EGFL7 0.971859117235239 5.30236555707088e-09 -0.905322498884989 0.00108294227613728 miRNAWalker2_validate -0.264315359200825 0.0010359433711446 NA NA NA hsa-let-7a-3p EPHA3 1.42015538786275 7.03375209382654e-13 -3.17995997634921 4.72542752542387e-15 mirMAP;miRNATAP -0.552065573112731 2.91990924878489e-08 NA NA NA hsa-let-7a-5p EPHA3 0.618599506841644 2.76973453058748e-05 -3.17995997634921 4.72542752542387e-15 TargetScan;miRNATAP -0.710980125930969 2.67101892992321e-07 NA NA NA hsa-let-7b-3p EPHA3 0.868207752019623 1.30460056774366e-05 -3.17995997634921 4.72542752542387e-15 mirMAP;miRNATAP -0.384847006745006 0.000155562600597526 NA NA NA hsa-let-7b-5p EPHA3 0.604314269683977 0.00140009936153214 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.514201467085214 1.6602784439924e-06 NA NA NA hsa-let-7e-5p EPHA3 0.860104282510173 6.04758298373779e-05 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.292393712577585 0.00202741036213734 NA NA NA hsa-let-7f-1-3p EPHA3 1.55054488387679 7.31326775537952e-11 -3.17995997634921 4.72542752542387e-15 mirMAP -0.401928046041304 2.69218362693991e-06 NA NA NA hsa-let-7f-5p EPHA3 0.495648727272215 0.00355972741198794 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.365818359405975 0.00249678183324821 NA NA NA hsa-let-7g-3p EPHA3 3.26398061402445 3.96263126107645e-25 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.597408295733414 5.54595403700316e-24 NA NA NA hsa-let-7g-5p EPHA3 1.20061455355116 1.50237505511483e-12 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.81796263275892 1.37736050216732e-12 NA NA NA hsa-miR-103a-3p EPHA3 1.44083190496858 1.53799939616416e-13 -3.17995997634921 4.72542752542387e-15 MirTarget -0.843661400548602 9.25989233069433e-18 NA NA NA hsa-miR-107 EPHA3 1.30977326593435 1.30372468603965e-11 -3.17995997634921 4.72542752542387e-15 MirTarget;miRanda;miRNATAP -0.587838669542827 8.31914357077277e-09 NA NA NA hsa-miR-125a-3p EPHA3 1.24490295132072 5.26925231010328e-06 -3.17995997634921 4.72542752542387e-15 miRanda -0.208990784073532 0.00468514819591026 NA NA NA hsa-miR-144-3p EPHA3 0.658119849508907 0.146943823997989 -3.17995997634921 4.72542752542387e-15 MirTarget -0.192072630765972 2.89897009539692e-05 NA NA NA hsa-miR-148a-5p EPHA3 1.16173838132242 0.000148929299881612 -3.17995997634921 4.72542752542387e-15 mirMAP -0.225013142763082 0.000636346571184685 NA NA NA hsa-miR-181a-5p EPHA3 2.29556023480783 1.8138457900616e-21 -3.17995997634921 4.72542752542387e-15 mirMAP -0.536787509074022 9.02544003494992e-12 NA NA NA hsa-miR-181b-5p EPHA3 2.49307679431293 3.92829250217627e-20 -3.17995997634921 4.72542752542387e-15 mirMAP -0.506431092314697 4.13874217432157e-13 NA NA NA hsa-miR-181c-5p EPHA3 1.58587920618301 1.57506918816933e-10 -3.17995997634921 4.72542752542387e-15 mirMAP -0.391438081014547 9.40848414246989e-07 NA NA NA hsa-miR-182-5p EPHA3 3.53923166221814 5.07781258121574e-21 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.431286004950732 2.49229724892096e-18 NA NA NA hsa-miR-194-5p EPHA3 1.8992998339217 3.76507853301977e-10 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.403597057506416 4.02350645232695e-10 NA NA NA hsa-miR-196a-5p EPHA3 1.52993069622497 0.00397268663639603 -3.17995997634921 4.72542752542387e-15 MirTarget -0.115572519991707 0.00239627904654189 NA NA NA hsa-miR-196b-5p EPHA3 1.71646270856386 4.37735885910369e-09 -3.17995997634921 4.72542752542387e-15 MirTarget -0.367765888375519 5.11380224957502e-08 NA NA NA hsa-miR-22-5p EPHA3 1.88011544159252 1.63978222572222e-16 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.258653875909547 0.00273499416233666 NA NA NA hsa-miR-29a-5p EPHA3 1.46749674755271 3.34605004270294e-07 -3.17995997634921 4.72542752542387e-15 mirMAP -0.384339349239047 1.45650210182581e-07 25153510 Second the direct interaction between one of the upregulated mRNA target the LOX gene which is an EMT key player and a downregulated miRNA the miR-29a was experimentally validated by a luciferase assay in HEK cell thyroid cancer hsa-miR-29b-3p EPHA3 1.65828197923813 1.02676780888141e-09 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.582149471699509 2.62521184370947e-16 NA NA NA hsa-miR-342-3p EPHA3 1.49115144672245 1.43879249744621e-07 -3.17995997634921 4.72542752542387e-15 miRanda -0.290825880300443 3.6846622395657e-05 NA NA NA hsa-miR-34c-5p EPHA3 2.07190852984647 7.35776320806257e-08 -3.17995997634921 4.72542752542387e-15 miRanda -0.160005653070916 0.00392550427091327 NA NA NA hsa-miR-3607-3p EPHA3 2.68532138541128 5.66716351955047e-14 -3.17995997634921 4.72542752542387e-15 MirTarget;miRNATAP -0.43563011607039 2.0146673730099e-15 NA NA NA hsa-miR-3614-5p EPHA3 2.17736331059655 2.19144831318484e-08 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.29431604871226 2.03304262971077e-08 NA NA NA hsa-miR-362-3p EPHA3 2.0756816987665 3.89026064579331e-12 -3.17995997634921 4.72542752542387e-15 miRanda -0.287228455915487 2.5136767615399e-05 NA NA NA hsa-miR-421 EPHA3 1.17791565395543 6.78526676976629e-06 -3.17995997634921 4.72542752542387e-15 miRanda -0.377306431673563 8.47030536138097e-07 NA NA NA hsa-miR-429 EPHA3 4.48815175680773 2.44117492218206e-17 -3.17995997634921 4.72542752542387e-15 miRanda -0.263449230571172 1.82447364550083e-13 NA NA NA hsa-miR-455-5p EPHA3 2.2582442061694 1.43472128037398e-13 -3.17995997634921 4.72542752542387e-15 miRanda -0.353116271042193 3.13877722946572e-08 NA NA NA hsa-miR-486-5p EPHA3 -0.194913133034028 0.607377798807705 -3.17995997634921 4.72542752542387e-15 MirTarget;PITA;miRanda;miRNATAP -0.160412972067463 0.00276630941527246 NA NA NA hsa-miR-590-3p EPHA3 2.59289455139753 1.03200520972022e-21 -3.17995997634921 4.72542752542387e-15 MirTarget;miRanda;mirMAP -0.604733375041007 1.26965647912017e-17 NA NA NA hsa-miR-590-5p EPHA3 3.18300989862077 2.06813568597893e-26 -3.17995997634921 4.72542752542387e-15 miRanda -0.575556458425523 4.69981096166905e-20 NA NA NA hsa-miR-628-5p EPHA3 0.799263053510813 2.28892357418044e-05 -3.17995997634921 4.72542752542387e-15 MirTarget;miRNATAP -0.23012940023215 0.0337332202726105 NA NA NA hsa-miR-7-1-3p EPHA3 1.84950311431067 1.25300363397654e-13 -3.17995997634921 4.72542752542387e-15 mirMAP -0.582819810223073 4.14768006762985e-14 NA NA NA hsa-miR-7-5p EPHA3 2.28980165299999 1.5131097560452e-07 -3.17995997634921 4.72542752542387e-15 miRNATAP -0.246047080020088 5.02240309986993e-07 NA NA NA hsa-miR-93-3p EPHA3 2.85383869771942 5.64481766902125e-23 -3.17995997634921 4.72542752542387e-15 MirTarget -0.663273791349796 4.70236500200659e-26 NA NA NA hsa-miR-944 EPHA3 2.91186649218281 1.31574753528144e-06 -3.17995997634921 4.72542752542387e-15 mirMAP -0.268505421820196 6.74922774301783e-16 NA NA NA hsa-miR-96-5p EPHA3 4.89433085814374 1.92000659886961e-31 -3.17995997634921 4.72542752542387e-15 MirTarget;TargetScan;miRNATAP -0.417143087858301 2.10859293645955e-21 NA NA NA hsa-miR-182-5p EPHB1 3.53923166221814 5.07781258121574e-21 -2.06632027088443 2.47699644252697e-06 MirTarget;miRNATAP -0.410556792921227 6.28130511261273e-15 NA NA NA hsa-miR-186-5p EPHB1 1.47445398888668 3.0781726595413e-15 -2.06632027088443 2.47699644252697e-06 miRNATAP -0.625786190650501 1.58465039981511e-08 NA NA NA hsa-miR-29b-2-5p EPHB1 0.910668640983475 0.00666655585493488 -2.06632027088443 2.47699644252697e-06 MirTarget -0.463877466259457 8.50820390581094e-14 NA NA NA hsa-miR-335-3p EPHB1 3.08791651139852 5.31309869723517e-12 -2.06632027088443 2.47699644252697e-06 mirMAP -0.203039348769339 1.18224146438432e-05 NA NA NA hsa-miR-339-5p EPHB1 2.68710938429893 3.03134080808154e-16 -2.06632027088443 2.47699644252697e-06 miRanda -0.283099357808581 5.9387858709701e-06 NA NA NA hsa-miR-361-5p EPHB1 0.971859117235239 5.30236555707088e-09 -2.06632027088443 2.47699644252697e-06 miRanda -0.847554239918289 1.71879571101715e-11 NA NA NA hsa-miR-362-3p EPHB1 2.0756816987665 3.89026064579331e-12 -2.06632027088443 2.47699644252697e-06 miRanda -0.202758496938367 0.00512859689953061 NA NA NA hsa-miR-455-3p EPHB1 3.06093594997644 3.54590649799868e-16 -2.06632027088443 2.47699644252697e-06 MirTarget -0.202062093045718 0.000234079372805345 NA NA NA hsa-miR-455-5p EPHB1 2.2582442061694 1.43472128037398e-13 -2.06632027088443 2.47699644252697e-06 miRanda -0.175866711981991 0.010115294962641 NA NA NA hsa-miR-590-3p EPHB1 2.59289455139753 1.03200520972022e-21 -2.06632027088443 2.47699644252697e-06 miRanda -0.363527080127523 2.34512955867245e-06 NA NA NA hsa-miR-629-3p EPHB1 2.36570947321815 1.33458201201618e-11 -2.06632027088443 2.47699644252697e-06 MirTarget -0.146019752422492 0.031598937319462 NA NA NA hsa-miR-96-5p EPHB1 4.89433085814374 1.92000659886961e-31 -2.06632027088443 2.47699644252697e-06 miRNATAP -0.353870840675161 7.53640754477556e-14 NA NA NA hsa-let-7b-3p ERBB4 0.868207752019623 1.30460056774366e-05 -0.99392595585163 0.14130085734173 mirMAP;miRNATAP -0.364750765592245 0.0266948569771243 NA NA NA hsa-let-7f-1-3p ERBB4 1.55054488387679 7.31326775537952e-11 -0.99392595585163 0.14130085734173 mirMAP -0.41066341147577 0.00310119974868269 NA NA NA hsa-miR-142-5p ERBB4 1.17581605694506 0.0018174701991234 -0.99392595585163 0.14130085734173 PITA;mirMAP -0.397175214083108 3.52542621525407e-06 NA NA NA hsa-miR-143-3p ERBB4 -2.5789192793377 1.55518999614836e-14 -0.99392595585163 0.14130085734173 miRNATAP -0.205756992255883 0.0294777260385657 NA NA NA hsa-miR-146a-5p ERBB4 1.19829319599115 0.00157081974524452 -0.99392595585163 0.14130085734173 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269781013507426 0.00165565939410554 NA NA NA hsa-miR-146b-5p ERBB4 1.75587235896724 1.15724631266659e-07 -0.99392595585163 0.14130085734173 PITA;miRNATAP -0.631951221038042 3.3057519844986e-11 NA NA NA hsa-miR-155-5p ERBB4 1.20164021433135 0.00086170622431261 -0.99392595585163 0.14130085734173 mirMAP -0.472979155720827 1.12679348305183e-07 NA NA NA hsa-miR-193b-3p ERBB4 2.25711804611899 4.1940744806631e-14 -0.99392595585163 0.14130085734173 MirTarget;miRNATAP -0.49050262650457 3.25123713742336e-06 NA NA NA hsa-miR-199a-3p ERBB4 0.640600337515787 0.0380326905134914 -0.99392595585163 0.14130085734173 PITA;miRNATAP -0.38951051152674 0.000225837541183071 NA NA NA hsa-miR-199b-3p ERBB4 0.643923492750702 0.0371742251925406 -0.99392595585163 0.14130085734173 PITA;miRNATAP -0.389329847707407 0.000225014210910171 NA NA NA hsa-miR-221-3p ERBB4 0.451556679024397 0.0909808299917811 -0.99392595585163 0.14130085734173 miRNATAP -0.901874238637453 4.15672419942138e-14 NA NA NA hsa-miR-222-3p ERBB4 0.851783756239071 0.00266783568486918 -0.99392595585163 0.14130085734173 miRNATAP -0.819823431225013 2.69270870414616e-13 NA NA NA hsa-miR-23a-3p ERBB4 1.00493340843378 2.55313889288924e-08 -0.99392595585163 0.14130085734173 miRNATAP -0.929143093325369 1.97828076705967e-07 NA NA NA hsa-miR-27a-5p ERBB4 0.0545598990316276 0.869091561924187 -0.99392595585163 0.14130085734173 miRNATAP -0.34998656998056 0.000393419099836851 NA NA NA hsa-miR-455-5p ERBB4 2.2582442061694 1.43472128037398e-13 -0.99392595585163 0.14130085734173 miRNATAP -0.416947812659995 5.63878225512738e-05 NA NA NA hsa-miR-485-3p ERBB4 0.442820096243914 0.166634696770945 -0.99392595585163 0.14130085734173 mirMAP -0.202885148969296 0.0498473285615985 NA NA NA hsa-let-7d-5p ERCC4 1.33236798905207 1.1741085658466e-13 -0.278481031858411 0.0788275175974168 MirTarget;miRNATAP -0.122821205972434 0.00332651420874814 NA NA NA hsa-let-7g-5p ERCC4 1.20061455355116 1.50237505511483e-12 -0.278481031858411 0.0788275175974168 MirTarget;miRNATAP -0.201579059738475 5.03260217772617e-06 NA NA NA hsa-miR-186-5p ERCC4 1.47445398888668 3.0781726595413e-15 -0.278481031858411 0.0788275175974168 mirMAP -0.102574851726133 0.0103603006203121 NA NA NA hsa-miR-19b-3p ERCC4 2.49529833021187 1.57028265846699e-23 -0.278481031858411 0.0788275175974168 MirTarget -0.105582135003513 0.000271892994467755 NA NA NA hsa-miR-30b-5p ERCC4 0.800822374912712 0.000133601914525413 -0.278481031858411 0.0788275175974168 MirTarget;mirMAP -0.141059125080648 0.000105955792371274 NA NA NA hsa-miR-30c-5p ERCC4 0.778774633108 0.000285599212429136 -0.278481031858411 0.0788275175974168 MirTarget;mirMAP -0.194427505654967 3.40424913793877e-08 NA NA NA hsa-miR-30e-5p ERCC4 1.23904909539663 1.35561917122157e-09 -0.278481031858411 0.0788275175974168 MirTarget -0.16245587431334 9.88047521141734e-06 NA NA NA hsa-miR-320a ERCC4 0.438165828017084 0.0390159073347133 -0.278481031858411 0.0788275175974168 miRanda -0.169247743553282 2.5787205092463e-06 NA NA NA hsa-miR-454-3p ERCC4 2.47234127820054 1.12878018736016e-21 -0.278481031858411 0.0788275175974168 MirTarget -0.102149460004182 0.000411287553420737 NA NA NA hsa-miR-576-5p ERCC4 2.20467023993664 3.4053475193793e-19 -0.278481031858411 0.0788275175974168 mirMAP -0.110490495525326 0.000202365193407868 NA NA NA hsa-miR-107 ERG 1.30977326593435 1.30372468603965e-11 -1.3479378771967 2.23511589174121e-07 miRanda -0.313511487883179 1.13979403354954e-06 NA NA NA hsa-miR-141-3p ERG 5.02396127982626 2.19224509139725e-24 -1.3479378771967 2.23511589174121e-07 MirTarget;TargetScan -0.253013233433548 1.37986124332074e-28 NA NA NA hsa-miR-181a-5p ERG 2.29556023480783 1.8138457900616e-21 -1.3479378771967 2.23511589174121e-07 mirMAP;miRNATAP -0.206432335097897 4.04318225885621e-05 NA NA NA hsa-miR-181b-5p ERG 2.49307679431293 3.92829250217627e-20 -1.3479378771967 2.23511589174121e-07 mirMAP;miRNATAP -0.205872284156934 4.0598924951264e-06 NA NA NA hsa-miR-181c-5p ERG 1.58587920618301 1.57506918816933e-10 -1.3479378771967 2.23511589174121e-07 mirMAP;miRNATAP -0.24887788092057 6.82855156017e-07 NA NA NA hsa-miR-182-5p ERG 3.53923166221814 5.07781258121574e-21 -1.3479378771967 2.23511589174121e-07 mirMAP -0.265659700435345 1.23871055142559e-17 NA NA NA hsa-miR-194-5p ERG 1.8992998339217 3.76507853301977e-10 -1.3479378771967 2.23511589174121e-07 MirTarget -0.202502371103508 7.29540949047768e-07 NA NA NA hsa-miR-196b-5p ERG 1.71646270856386 4.37735885910369e-09 -1.3479378771967 2.23511589174121e-07 miRNATAP -0.281673740872863 2.04531088613062e-11 20570349 The role of microRNA 196a and microRNA 196b as ERG regulators in acute myeloid leukemia and acute T lymphoblastic leukemia; In conclusion our results identify miR-196a and miR-196b as ERG regulators and implicate a potential role for these miRNAs in acute leukemia acute myeloid leukemia hsa-miR-200a-3p ERG 4.59434485520731 6.38952518573476e-18 -1.3479378771967 2.23511589174121e-07 MirTarget -0.208671592860991 1.31326876196534e-21 NA NA NA hsa-miR-200b-3p ERG 3.78235093249346 3.18343003239465e-14 -1.3479378771967 2.23511589174121e-07 TargetScan -0.208917910112113 1.56818488572204e-18 27191272 The tumor suppressive miR 200b subfamily is an ERG target gene in human prostate tumors; Although induction of the tumor suppressive miR-200b subfamily by oncogenic ERG appears to be counterintuitive it is consistent with the observation that the vast majority of primary prostate cancers are slow-growing and indolent prostate cancer hsa-miR-20a-3p ERG 2.92621109947706 2.49504904635375e-17 -1.3479378771967 2.23511589174121e-07 miRNATAP -0.264268419543668 9.47185097553758e-14 NA NA NA hsa-miR-27a-3p ERG 1.66542180327138 4.93775737894805e-13 -1.3479378771967 2.23511589174121e-07 miRNATAP -0.144162103599756 0.00780426518464396 NA NA NA hsa-miR-29a-5p ERG 1.46749674755271 3.34605004270294e-07 -1.3479378771967 2.23511589174121e-07 mirMAP -0.112724424090472 0.0153406970720617 NA NA NA hsa-miR-3065-5p ERG 2.74629919868982 1.86846589298284e-08 -1.3479378771967 2.23511589174121e-07 mirMAP -0.184526981279971 2.576737919215e-09 NA NA NA hsa-miR-30b-5p ERG 0.800822374912712 0.000133601914525413 -1.3479378771967 2.23511589174121e-07 miRNATAP -0.236015032218044 0.000102301349394009 NA NA NA hsa-miR-30c-5p ERG 0.778774633108 0.000285599212429136 -1.3479378771967 2.23511589174121e-07 miRNATAP -0.254743875820041 1.69990354955611e-05 NA NA NA hsa-miR-30d-5p ERG 0.675423997639582 0.00270618816039773 -1.3479378771967 2.23511589174121e-07 miRNATAP -0.274636093833775 1.0972540024007e-06 NA NA NA hsa-miR-320a ERG 0.438165828017084 0.0390159073347133 -1.3479378771967 2.23511589174121e-07 miRanda -0.142508087121842 0.0188659709544294 NA NA NA hsa-miR-320b ERG 1.55692969039548 1.41071034251915e-08 -1.3479378771967 2.23511589174121e-07 miRanda -0.210873458970906 3.5656567032233e-06 NA NA NA hsa-miR-330-3p ERG 0.876747334239085 0.00073709016089703 -1.3479378771967 2.23511589174121e-07 mirMAP -0.224375483376382 4.11511679093614e-06 NA NA NA hsa-miR-33a-3p ERG 1.72765312072219 1.51784443453521e-07 -1.3479378771967 2.23511589174121e-07 mirMAP -0.187492068900513 7.24008621256839e-06 NA NA NA hsa-miR-361-5p ERG 0.971859117235239 5.30236555707088e-09 -1.3479378771967 2.23511589174121e-07 PITA;miRanda;miRNATAP -0.430022433743389 1.19760104824398e-08 NA NA NA hsa-miR-429 ERG 4.48815175680773 2.44117492218206e-17 -1.3479378771967 2.23511589174121e-07 miRanda;miRNATAP -0.200641579771805 1.16007916183554e-19 NA NA NA hsa-miR-590-3p ERG 2.59289455139753 1.03200520972022e-21 -1.3479378771967 2.23511589174121e-07 miRanda -0.271287304169954 2.31660781252708e-09 NA NA NA hsa-miR-590-5p ERG 3.18300989862077 2.06813568597893e-26 -1.3479378771967 2.23511589174121e-07 PITA;miRanda;miRNATAP -0.282961163366583 1.96333694789405e-12 NA NA NA hsa-miR-7-1-3p ERG 1.84950311431067 1.25300363397654e-13 -1.3479378771967 2.23511589174121e-07 mirMAP -0.271726689723598 3.32700447955702e-08 NA NA NA hsa-miR-944 ERG 2.91186649218281 1.31574753528144e-06 -1.3479378771967 2.23511589174121e-07 MirTarget;PITA;miRNATAP -0.116516206937141 4.60359758891416e-08 NA NA NA hsa-miR-96-5p ERG 4.89433085814374 1.92000659886961e-31 -1.3479378771967 2.23511589174121e-07 TargetScan -0.271217533254501 5.30751662377762e-23 NA NA NA hsa-let-7a-3p ESR1 1.42015538786275 7.03375209382654e-13 -2.8683110246507 7.71528352232079e-10 mirMAP -0.38227536373895 0.000809372261957143 20535543;21826373 Let 7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer; Next we performed bioinformatics analysis and found that let-7 miRNA sequences match sequence in the 3'-UTR of estrogen receptor alpha ER-α suggesting ER-α may be a target of let-7 which was further confirmed by a number of experimental assays including luciferase assay protein expression and mRNA expression;let 7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor α signaling in breast cancer ; breast cancer;breast cancer hsa-miR-107 ESR1 1.30977326593435 1.30372468603965e-11 -2.8683110246507 7.71528352232079e-10 PITA;miRanda;miRNATAP -0.3420180391177 0.00355642263570991 26033453 Estrogen-receptor negative tumors displayed higher concentrations of circulating miR-107 than their counterparts p = 0.035; However overexpression of miR-107 in MCF-7 cells did not downregulate estrogen receptor protein breast cancer hsa-miR-10b-3p ESR1 0.77597971642517 0.00264877454133753 -2.8683110246507 7.71528352232079e-10 mirMAP -0.281948106034304 0.00157081734445387 NA NA NA hsa-miR-129-5p ESR1 -0.524170159980738 0.222582956006346 -2.8683110246507 7.71528352232079e-10 miRanda;miRNATAP -0.143585193937193 0.0086557889400341 NA NA NA hsa-miR-130a-3p ESR1 2.02021855058359 1.26427102520415e-11 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.244601365865072 0.0011698145989319 NA NA NA hsa-miR-130b-3p ESR1 3.5350292994509 1.73934183852569e-27 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.524848766151769 2.54951434084372e-16 NA NA NA hsa-miR-130b-5p ESR1 2.9963110846538 1.98883029416455e-18 -2.8683110246507 7.71528352232079e-10 mirMAP -0.455598316259551 1.932034058515e-12 NA NA NA hsa-miR-17-5p ESR1 3.2710598467455 9.93128340539455e-27 -2.8683110246507 7.71528352232079e-10 TargetScan -0.570865960856884 6.22446473424376e-17 NA NA NA hsa-miR-181a-5p ESR1 2.29556023480783 1.8138457900616e-21 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.360972890053082 7.04289146044038e-05 NA NA NA hsa-miR-181b-5p ESR1 2.49307679431293 3.92829250217627e-20 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.353952022469703 1.16085402730615e-05 NA NA NA hsa-miR-181c-5p ESR1 1.58587920618301 1.57506918816933e-10 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.247364070285803 0.00678626958672793 NA NA NA hsa-miR-186-5p ESR1 1.47445398888668 3.0781726595413e-15 -2.8683110246507 7.71528352232079e-10 mirMAP -0.639093106750858 7.83600731944882e-08 NA NA NA hsa-miR-188-5p ESR1 2.52825126596644 6.78099435999778e-14 -2.8683110246507 7.71528352232079e-10 PITA;miRNATAP -0.162408409036189 0.0216530532153401 NA NA NA hsa-miR-18a-3p ESR1 2.14813400940323 2.23460809936028e-06 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.358976490937224 9.11548009858741e-09 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-18a-5p ESR1 3.78535678765353 3.72446596213886e-26 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.435932301136626 2.88295866669623e-12 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-193a-3p ESR1 1.60460546928078 2.86169793322984e-07 -2.8683110246507 7.71528352232079e-10 miRanda -0.154307362913701 0.0343651205465129 NA NA NA hsa-miR-193b-3p ESR1 2.25711804611899 4.1940744806631e-14 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase -0.250913411131851 0.000783784347482666 NA NA NA hsa-miR-19a-3p ESR1 3.42309334186656 3.02671914353412e-28 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.475018441759663 2.31368633781198e-12 26416600 We speculate that miR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1 which influences the occurrence and development of breast cancer cells with different levels of ER expression breast cancer hsa-miR-19b-3p ESR1 2.49529833021187 1.57028265846699e-23 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.586123351306929 7.88064168199894e-12 NA NA NA hsa-miR-20b-5p ESR1 2.07706563022469 1.10107236083433e-05 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase -0.10001813259544 0.0383961541199103 NA NA NA hsa-miR-26b-5p ESR1 0.885393662798425 3.2116297961629e-06 -2.8683110246507 7.71528352232079e-10 mirMAP;miRNATAP -0.389804614922 0.00128442920885857 NA NA NA hsa-miR-29b-3p ESR1 1.65828197923813 1.02676780888141e-09 -2.8683110246507 7.71528352232079e-10 miRNAWalker2_validate;miRTarBase -0.18497875298944 0.0268370235980416 25622979 In the present study we show that S100A7 significantly upregulates the expression of miR-29b in Estrogen Receptor ER-positive breast cancer cells represented by MCF7 and significantly downregulates miR-29b in ER-negative cells represented by MDA-MB-231 Corrected breast cancer hsa-miR-301a-3p ESR1 2.81024345929638 2.29784847962242e-17 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.404509434143612 6.17646487943025e-09 NA NA NA hsa-miR-3065-5p ESR1 2.74629919868982 1.86846589298284e-08 -2.8683110246507 7.71528352232079e-10 mirMAP -0.220524359966854 9.71688159465192e-05 NA NA NA hsa-miR-30d-3p ESR1 0.977747550180601 4.3048212205381e-05 -2.8683110246507 7.71528352232079e-10 mirMAP -0.252211491593788 0.00883761005114691 NA NA NA hsa-miR-32-3p ESR1 2.02436999565685 5.94091197945307e-09 -2.8683110246507 7.71528352232079e-10 mirMAP -0.193816343091053 0.00909896905399655 NA NA NA hsa-miR-320a ESR1 0.438165828017084 0.0390159073347133 -2.8683110246507 7.71528352232079e-10 PITA;mirMAP -0.340240686445187 0.0018452364000788 25120655 Receiver operator characteristic curves revealed that the prognostic value of miR-320a was enhanced when compared with the widely used prognostic biomarkers estrogen receptor progesterone receptor and human epidermal growth factor-2 in invasive breast cancer breast cancer hsa-miR-320b ESR1 1.55692969039548 1.41071034251915e-08 -2.8683110246507 7.71528352232079e-10 PITA;mirMAP -0.323318423810826 8.71881892978145e-05 NA NA NA hsa-miR-324-5p ESR1 2.95683728155095 1.32960514360912e-20 -2.8683110246507 7.71528352232079e-10 PITA -0.406025023853251 2.40981210174164e-09 NA NA NA hsa-miR-330-3p ESR1 0.876747334239085 0.00073709016089703 -2.8683110246507 7.71528352232079e-10 PITA;mirMAP;miRNATAP -0.293392302784421 0.000910705401126492 NA NA NA hsa-miR-33a-3p ESR1 1.72765312072219 1.51784443453521e-07 -2.8683110246507 7.71528352232079e-10 mirMAP -0.262987808508062 0.000519843843995116 NA NA NA hsa-miR-3607-3p ESR1 2.68532138541128 5.66716351955047e-14 -2.8683110246507 7.71528352232079e-10 mirMAP -0.216096541548397 0.000746870985415676 NA NA NA hsa-miR-361-5p ESR1 0.971859117235239 5.30236555707088e-09 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.676987446185421 7.46280654517592e-07 NA NA NA hsa-miR-3913-5p ESR1 2.44353493655328 8.95279496632448e-15 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.27328468835081 0.000168872620214045 NA NA NA hsa-miR-429 ESR1 4.48815175680773 2.44117492218206e-17 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.205939283065721 6.0164980002655e-07 NA NA NA hsa-miR-454-3p ESR1 2.47234127820054 1.12878018736016e-21 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.376361434072454 1.45187163610477e-05 NA NA NA hsa-miR-455-5p ESR1 2.2582442061694 1.43472128037398e-13 -2.8683110246507 7.71528352232079e-10 miRanda -0.239381430504342 0.00107152137057565 NA NA NA hsa-miR-589-3p ESR1 2.51971841868825 2.39125940264107e-11 -2.8683110246507 7.71528352232079e-10 mirMAP -0.232196541161285 0.000610089599476939 NA NA NA hsa-miR-590-3p ESR1 2.59289455139753 1.03200520972022e-21 -2.8683110246507 7.71528352232079e-10 miRanda;mirMAP;miRNATAP -0.240583145983294 0.00386957265261124 NA NA NA hsa-miR-629-3p ESR1 2.36570947321815 1.33458201201618e-11 -2.8683110246507 7.71528352232079e-10 mirMAP -0.218147980961709 0.00269033356294057 NA NA NA hsa-miR-660-5p ESR1 1.82692095272076 1.92040083607196e-13 -2.8683110246507 7.71528352232079e-10 miRNATAP -0.234245936283355 0.00964972458526509 NA NA NA hsa-miR-664a-3p ESR1 0.634721925861133 0.00520070178640421 -2.8683110246507 7.71528352232079e-10 mirMAP -0.235352877314957 0.0210172259523165 NA NA NA hsa-miR-7-5p ESR1 2.28980165299999 1.5131097560452e-07 -2.8683110246507 7.71528352232079e-10 mirMAP -0.142313841133465 0.0112054692587855 NA NA NA hsa-miR-9-5p ESR1 1.02304182473283 0.042901377604859 -2.8683110246507 7.71528352232079e-10 mirMAP;miRNATAP -0.134357667590382 0.003104021814617 22723919 Higher expression of miR-9 was significantly associated with breast cancer LR in all cases as well as the subset of estrogen receptor ER positive cases p = 0.02 breast cancer hsa-miR-101-3p ETV1 0.522819989585461 0.00375627731618038 -0.692329659136899 0.0382321004079818 miRNATAP -0.296640847459104 0.00104098618713927 NA NA NA hsa-miR-106a-5p ETV1 2.48882002962836 1.99757727374521e-12 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.260425779908911 2.72817275994871e-09 NA NA NA hsa-miR-106b-5p ETV1 2.46782146831112 1.36171495805632e-23 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.446807349903496 1.75934851411523e-13 NA NA NA hsa-miR-126-5p ETV1 0.895338176458417 2.33372756450713e-05 -0.692329659136899 0.0382321004079818 MirTarget;mirMAP -0.310822464744556 4.33567359975323e-05 NA NA NA hsa-miR-144-3p ETV1 0.658119849508907 0.146943823997989 -0.692329659136899 0.0382321004079818 miRNATAP -0.196012793249706 6.72529950770323e-08 NA NA NA hsa-miR-16-2-3p ETV1 2.31623086727196 4.29838149388188e-20 -0.692329659136899 0.0382321004079818 mirMAP -0.402276386151864 2.20393600210962e-11 NA NA NA hsa-miR-17-5p ETV1 3.2710598467455 9.93128340539455e-27 -0.692329659136899 0.0382321004079818 MirTarget;TargetScan;miRNATAP -0.356712742033627 1.6584244897151e-13 26158900 miR 17 regulates melanoma cell motility by inhibiting the translation of ETV1; TargetScan algorithm predicts the PEA3-subfamily member ETV1 as a direct target of miR-17; Indeed a 3-4-fold decrease of ETV1 protein levels are observed following miR-17 transfection into the various melanoma lines with no significant change in ETV1 mRNA expression; Dual luciferase experiments demonstrate direct binding of miR-17 to the 3'-untranslated region of ETV1 confirmed by abolishing point mutations in the putative binding site; These combined results suggest regulation of ETV1 by miR-17 by a direct translational repression; In conclusion we show a new role for miR-17 in melanoma facilitating cell motility by targeting the translation of ETV1 protein which may support the development of metastasis motility;metastasis melanoma hsa-miR-193b-3p ETV1 2.25711804611899 4.1940744806631e-14 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.172949665812341 0.00098074933087306 NA NA NA hsa-miR-19a-3p ETV1 3.42309334186656 3.02671914353412e-28 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.309070059151936 9.68198527307411e-11 NA NA NA hsa-miR-19b-3p ETV1 2.49529833021187 1.57028265846699e-23 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.419831668021342 2.82048567339907e-12 NA NA NA hsa-miR-20a-5p ETV1 3.15577933619191 4.19753346442454e-25 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.350467090136899 6.69149451368424e-13 NA NA NA hsa-miR-20b-5p ETV1 2.07706563022469 1.10107236083433e-05 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.177495406057297 1.11254612184159e-07 NA NA NA hsa-miR-21-3p ETV1 2.19296355304364 4.63665722759779e-15 -0.692329659136899 0.0382321004079818 MirTarget -0.146241467667754 0.00909481683364281 NA NA NA hsa-miR-224-3p ETV1 1.87536386559317 6.15140969394846e-05 -0.692329659136899 0.0382321004079818 MirTarget -0.146209468350468 4.18330979403191e-05 NA NA NA hsa-miR-23a-3p ETV1 1.00493340843378 2.55313889288924e-08 -0.692329659136899 0.0382321004079818 MirTarget;mirMAP;miRNATAP -0.295578096895683 0.000923150417768162 NA NA NA hsa-miR-3065-5p ETV1 2.74629919868982 1.86846589298284e-08 -0.692329659136899 0.0382321004079818 mirMAP -0.124705706678239 0.00175450844907288 NA NA NA hsa-miR-320a ETV1 0.438165828017084 0.0390159073347133 -0.692329659136899 0.0382321004079818 MirTarget;PITA;miRanda;miRNATAP -0.24493857710513 0.00140493086437731 NA NA NA hsa-miR-320b ETV1 1.55692969039548 1.41071034251915e-08 -0.692329659136899 0.0382321004079818 MirTarget;PITA;miRanda;miRNATAP -0.238690685600061 3.63740190223251e-05 NA NA NA hsa-miR-330-3p ETV1 0.876747334239085 0.00073709016089703 -0.692329659136899 0.0382321004079818 PITA;mirMAP -0.367178122506391 1.98591873878801e-09 NA NA NA hsa-miR-33a-3p ETV1 1.72765312072219 1.51784443453521e-07 -0.692329659136899 0.0382321004079818 MirTarget;mirMAP -0.317325911000441 1.44752229621163e-09 NA NA NA hsa-miR-421 ETV1 1.17791565395543 6.78526676976629e-06 -0.692329659136899 0.0382321004079818 miRanda -0.252904426608407 3.63216989770402e-05 NA NA NA hsa-miR-429 ETV1 4.48815175680773 2.44117492218206e-17 -0.692329659136899 0.0382321004079818 miRanda;miRNATAP -0.180306303154592 3.4775203093246e-10 NA NA NA hsa-miR-455-3p ETV1 3.06093594997644 3.54590649799868e-16 -0.692329659136899 0.0382321004079818 PITA;miRNATAP -0.10850043533134 0.00899676671917523 NA NA NA hsa-miR-491-5p ETV1 0.615770352820862 0.0418295628761654 -0.692329659136899 0.0382321004079818 miRanda -0.151054443185149 0.00855163227048801 NA NA NA hsa-miR-505-5p ETV1 1.89243395287645 9.82003586561819e-12 -0.692329659136899 0.0382321004079818 MirTarget -0.294289802599579 1.75058286814595e-07 NA NA NA hsa-miR-532-3p ETV1 1.96631878320218 4.53421954361695e-13 -0.692329659136899 0.0382321004079818 PITA -0.372867857920456 5.47511921411498e-11 NA NA NA hsa-miR-582-5p ETV1 0.609226359812689 0.032988717891497 -0.692329659136899 0.0382321004079818 MirTarget;PITA;miRNATAP -0.232735729393976 3.69056750965284e-05 NA NA NA hsa-miR-589-3p ETV1 2.51971841868825 2.39125940264107e-11 -0.692329659136899 0.0382321004079818 MirTarget -0.265387280046526 1.65416347779018e-08 NA NA NA hsa-miR-590-3p ETV1 2.59289455139753 1.03200520972022e-21 -0.692329659136899 0.0382321004079818 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.30877032338104 9.14390595627518e-08 NA NA NA hsa-miR-625-3p ETV1 1.18769734290812 2.47200238827911e-06 -0.692329659136899 0.0382321004079818 MirTarget -0.221796917557381 0.000484751240520711 NA NA NA hsa-miR-660-5p ETV1 1.82692095272076 1.92040083607196e-13 -0.692329659136899 0.0382321004079818 MirTarget -0.305438089020057 1.20900210342925e-06 NA NA NA hsa-miR-7-1-3p ETV1 1.84950311431067 1.25300363397654e-13 -0.692329659136899 0.0382321004079818 MirTarget;mirMAP -0.272590815077932 1.40868285543283e-05 NA NA NA hsa-miR-93-5p ETV1 3.03961860136032 1.11672209617395e-24 -0.692329659136899 0.0382321004079818 MirTarget;miRNATAP -0.391812988523773 4.42741873928797e-15 NA NA NA hsa-miR-940 ETV1 3.21011374578759 2.7923171128495e-14 -0.692329659136899 0.0382321004079818 MirTarget -0.192780542350673 1.5822107896513e-06 NA NA NA hsa-miR-944 ETV1 2.91186649218281 1.31574753528144e-06 -0.692329659136899 0.0382321004079818 mirMAP -0.184514821764226 5.1405505651259e-12 NA NA NA hsa-miR-139-5p EZH2 -1.52606598644743 1.20474151350665e-08 2.33394962409442 6.28922117868454e-22 miRanda -0.188081239905356 3.22418464864121e-05 NA NA NA hsa-miR-19b-1-5p FAM175A 2.57951428759379 4.31576118703427e-20 -0.924162537901044 1.12056550328837e-09 MirTarget -0.110864395234955 1.95366405888862e-05 NA NA NA hsa-miR-320b FAM175A 1.55692969039548 1.41071034251915e-08 -0.924162537901044 1.12056550328837e-09 miRanda -0.105022735726476 8.40819285054331e-05 NA NA NA hsa-miR-450b-5p FAM175A 1.69244418548325 1.68064054148881e-10 -0.924162537901044 1.12056550328837e-09 MirTarget -0.127504883625516 3.39098425709117e-06 NA NA NA hsa-miR-590-3p FAM175A 2.59289455139753 1.03200520972022e-21 -0.924162537901044 1.12056550328837e-09 miRanda -0.15161826112248 1.22086776196432e-08 NA NA NA hsa-miR-106a-5p FAM46C 2.48882002962836 1.99757727374521e-12 -1.66367766872796 7.82547314993614e-08 MirTarget;miRNATAP -0.149914596678629 0.000327774630785855 NA NA NA hsa-miR-106b-5p FAM46C 2.46782146831112 1.36171495805632e-23 -1.66367766872796 7.82547314993614e-08 MirTarget;miRNATAP -0.283369052953172 1.06388014439723e-06 NA NA NA hsa-miR-141-3p FAM46C 5.02396127982626 2.19224509139725e-24 -1.66367766872796 7.82547314993614e-08 TargetScan;miRNATAP -0.106435921017189 0.0002379062668133 NA NA NA hsa-miR-15a-5p FAM46C 2.34669284378787 1.69544424500258e-23 -1.66367766872796 7.82547314993614e-08 mirMAP -0.189744301188781 0.00204233137705867 NA NA NA hsa-miR-15b-5p FAM46C 1.57112623124278 9.14247846750597e-13 -1.66367766872796 7.82547314993614e-08 mirMAP -0.31375646672146 3.02336061577543e-06 NA NA NA hsa-miR-16-2-3p FAM46C 2.31623086727196 4.29838149388188e-20 -1.66367766872796 7.82547314993614e-08 mirMAP -0.216007730742318 0.000175164157551076 NA NA NA hsa-miR-16-5p FAM46C 1.75824877145857 1.68592440033108e-16 -1.66367766872796 7.82547314993614e-08 mirMAP -0.185517801581107 0.00738912557793884 NA NA NA hsa-miR-17-5p FAM46C 3.2710598467455 9.93128340539455e-27 -1.66367766872796 7.82547314993614e-08 MirTarget;TargetScan;miRNATAP -0.252829678735153 4.28882483142191e-08 NA NA NA hsa-miR-19a-3p FAM46C 3.42309334186656 3.02671914353412e-28 -1.66367766872796 7.82547314993614e-08 mirMAP;miRNATAP -0.191835920167328 2.54237531539491e-05 NA NA NA hsa-miR-19b-3p FAM46C 2.49529833021187 1.57028265846699e-23 -1.66367766872796 7.82547314993614e-08 miRNATAP -0.234214297706445 4.77296576128988e-05 NA NA NA hsa-miR-20a-5p FAM46C 3.15577933619191 4.19753346442454e-25 -1.66367766872796 7.82547314993614e-08 MirTarget;miRNATAP -0.232787590705284 5.84615382518239e-07 NA NA NA hsa-miR-224-5p FAM46C 2.94107125335675 5.72194099515157e-08 -1.66367766872796 7.82547314993614e-08 MirTarget -0.166615016315368 7.74801242406444e-10 NA NA NA hsa-miR-24-3p FAM46C 0.99989036772428 1.35595013650376e-07 -1.66367766872796 7.82547314993614e-08 miRNATAP -0.421708512599489 9.43640791891338e-08 NA NA NA hsa-miR-3065-5p FAM46C 2.74629919868982 1.86846589298284e-08 -1.66367766872796 7.82547314993614e-08 mirMAP -0.173095407413492 3.31855611396846e-06 NA NA NA hsa-miR-33a-3p FAM46C 1.72765312072219 1.51784443453521e-07 -1.66367766872796 7.82547314993614e-08 mirMAP -0.171998017494028 0.000589770431294352 NA NA NA hsa-miR-33a-5p FAM46C 3.79671563098419 1.15966309820345e-18 -1.66367766872796 7.82547314993614e-08 MirTarget -0.190053115370012 1.79879027191254e-07 NA NA NA hsa-miR-34c-3p FAM46C 2.41359195938096 3.46966584087088e-10 -1.66367766872796 7.82547314993614e-08 mirMAP -0.134090445746125 0.000819651600254592 NA NA NA hsa-miR-421 FAM46C 1.17791565395543 6.78526676976629e-06 -1.66367766872796 7.82547314993614e-08 miRanda;mirMAP -0.150021258098109 0.00963153703795341 NA NA NA hsa-miR-424-5p FAM46C 1.61930224569578 1.89642549274994e-10 -1.66367766872796 7.82547314993614e-08 mirMAP -0.122228791291998 0.038055158746644 NA NA NA hsa-miR-452-3p FAM46C 2.42521958420768 4.08754552781156e-07 -1.66367766872796 7.82547314993614e-08 mirMAP -0.142453874823656 4.98139536719987e-06 NA NA NA hsa-miR-576-5p FAM46C 2.20467023993664 3.4053475193793e-19 -1.66367766872796 7.82547314993614e-08 PITA -0.176688964504262 0.00290510796257469 NA NA NA hsa-miR-590-3p FAM46C 2.59289455139753 1.03200520972022e-21 -1.66367766872796 7.82547314993614e-08 miRanda;mirMAP -0.165355628270873 0.00263361986230867 NA NA NA hsa-miR-590-5p FAM46C 3.18300989862077 2.06813568597893e-26 -1.66367766872796 7.82547314993614e-08 miRanda -0.193136761919595 7.7921584472297e-05 NA NA NA hsa-miR-7-1-3p FAM46C 1.84950311431067 1.25300363397654e-13 -1.66367766872796 7.82547314993614e-08 mirMAP -0.193502915484726 0.00110740996698888 NA NA NA hsa-miR-9-5p FAM46C 1.02304182473283 0.042901377604859 -1.66367766872796 7.82547314993614e-08 MirTarget;miRNATAP -0.14511195070032 1.06355091835272e-06 NA NA NA hsa-miR-93-5p FAM46C 3.03961860136032 1.11672209617395e-24 -1.66367766872796 7.82547314993614e-08 MirTarget;miRNATAP -0.237443043951515 7.61260958234607e-07 NA NA NA hsa-miR-940 FAM46C 3.21011374578759 2.7923171128495e-14 -1.66367766872796 7.82547314993614e-08 miRNATAP -0.18164017663631 1.5133239720928e-06 NA NA NA hsa-miR-98-5p FAM46C 1.11154309866014 1.24143909012085e-08 -1.66367766872796 7.82547314993614e-08 miRNAWalker2_validate -0.175280674737513 0.0238187880959358 NA NA NA hsa-miR-146b-5p FLT1 1.75587235896724 1.15724631266659e-07 -0.398798139585047 0.102684609418445 miRanda -0.159935179058735 4.56535177014795e-06 NA NA NA hsa-miR-155-5p FLT1 1.20164021433135 0.00086170622431261 -0.398798139585047 0.102684609418445 miRNAWalker2_validate;mirMAP -0.124036074181 0.000133378861297828 NA NA NA hsa-miR-19a-3p FLT1 3.42309334186656 3.02671914353412e-28 -0.398798139585047 0.102684609418445 MirTarget -0.142945164779521 5.3933264147706e-05 NA NA NA hsa-miR-19b-3p FLT1 2.49529833021187 1.57028265846699e-23 -0.398798139585047 0.102684609418445 MirTarget -0.181991444657249 4.7083327417296e-05 NA NA NA hsa-miR-29a-5p FLT1 1.46749674755271 3.34605004270294e-07 -0.398798139585047 0.102684609418445 MirTarget -0.124373949621283 0.00379603474183942 NA NA NA hsa-miR-339-5p FLT1 2.68710938429893 3.03134080808154e-16 -0.398798139585047 0.102684609418445 miRanda -0.173745122508606 4.02337703117215e-07 NA NA NA hsa-miR-590-3p FLT1 2.59289455139753 1.03200520972022e-21 -0.398798139585047 0.102684609418445 miRanda -0.132919196101858 0.00184001108177259 NA NA NA hsa-miR-125a-5p FLT3 0.599529391575274 0.0102300147180307 -1.96802952624864 2.65981345780205e-05 miRanda -0.263480704467921 0.0074248734779586 NA NA NA hsa-miR-491-5p FLT3 0.615770352820862 0.0418295628761654 -1.96802952624864 2.65981345780205e-05 miRanda -0.22212906907477 0.00622648817980623 NA NA NA hsa-miR-590-3p FLT3 2.59289455139753 1.03200520972022e-21 -1.96802952624864 2.65981345780205e-05 PITA;miRanda;mirMAP;miRNATAP -0.189347699794977 0.0222763737551876 NA NA NA hsa-miR-331-3p FLT4 2.28379581858927 1.99663919173155e-18 -0.514633942951051 0.0469674197809773 miRNAWalker2_validate -0.146482440615543 0.0015099115945375 NA NA NA hsa-miR-28-5p FOXL2 0.230152919654905 0.0742909586754846 2.73454700103597 4.81076937832295e-05 miRanda -0.665229548093076 0.0114648896234277 NA NA NA hsa-let-7a-3p FOXP1 1.42015538786275 7.03375209382654e-13 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.176991282648588 5.60607767095511e-05 NA NA NA hsa-let-7b-3p FOXP1 0.868207752019623 1.30460056774366e-05 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.144400148776561 0.00121402435655974 NA NA NA hsa-let-7i-5p FOXP1 0.412877696970403 0.00622731051981756 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.229527636655815 0.000124888139121355 NA NA NA hsa-miR-103a-3p FOXP1 1.44083190496858 1.53799939616416e-13 -0.873044719534777 1.61392354745552e-06 MirTarget -0.189693488700403 1.9553106215455e-05 NA NA NA hsa-miR-107 FOXP1 1.30977326593435 1.30372468603965e-11 -0.873044719534777 1.61392354745552e-06 MirTarget;PITA;miRanda;miRNATAP -0.154398206411981 0.000638064957185171 NA NA NA hsa-miR-130b-3p FOXP1 3.5350292994509 1.73934183852569e-27 -0.873044719534777 1.61392354745552e-06 MirTarget -0.130698476921215 2.45130624046279e-07 NA NA NA hsa-miR-130b-5p FOXP1 2.9963110846538 1.98883029416455e-18 -0.873044719534777 1.61392354745552e-06 MirTarget -0.123977639944216 1.02029746987166e-06 NA NA NA hsa-miR-132-3p FOXP1 0.156276992635384 0.408190812100704 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.161406444054741 0.000698892208285045 NA NA NA hsa-miR-140-5p FOXP1 0.844753502512594 3.73722278438606e-05 -0.873044719534777 1.61392354745552e-06 miRanda -0.135034345140903 0.00187087232838508 NA NA NA hsa-miR-16-2-3p FOXP1 2.31623086727196 4.29838149388188e-20 -0.873044719534777 1.61392354745552e-06 mirMAP -0.247197341380208 5.03841178068827e-14 NA NA NA hsa-miR-17-3p FOXP1 2.2704817679209 1.1667437320211e-22 -0.873044719534777 1.61392354745552e-06 MirTarget;miRNATAP -0.213252763004033 3.15125766784346e-09 NA NA NA hsa-miR-181a-5p FOXP1 2.29556023480783 1.8138457900616e-21 -0.873044719534777 1.61392354745552e-06 MirTarget;miRNATAP -0.171899944349249 8.33449645512109e-07 NA NA NA hsa-miR-181b-5p FOXP1 2.49307679431293 3.92829250217627e-20 -0.873044719534777 1.61392354745552e-06 MirTarget;miRNATAP -0.163435220837626 1.35951388382722e-07 NA NA NA hsa-miR-186-5p FOXP1 1.47445398888668 3.0781726595413e-15 -0.873044719534777 1.61392354745552e-06 mirMAP -0.26474510605593 7.55120730603092e-09 NA NA NA hsa-miR-19a-3p FOXP1 3.42309334186656 3.02671914353412e-28 -0.873044719534777 1.61392354745552e-06 MirTarget;mirMAP;miRNATAP -0.191966487997966 1.79141947027513e-13 26367773 The four miR-19a target cDNA expression vectors suppressed cell viability colony formation migration and invasion of A549 and LK79 cells but LK79 cells transfected with FOXP1 and TP53INP1 cDNAs showed no difference compared to the control cells in the invasion assay lung cancer hsa-miR-19b-3p FOXP1 2.49529833021187 1.57028265846699e-23 -0.873044719534777 1.61392354745552e-06 MirTarget;mirMAP;miRNATAP -0.221118402044599 2.45970353675447e-11 NA NA NA hsa-miR-212-3p FOXP1 0.357878936470387 0.232446214501331 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.115213562242656 0.000111891819837673 NA NA NA hsa-miR-22-3p FOXP1 1.21545661147757 1.61670170137775e-13 -0.873044719534777 1.61392354745552e-06 miRNAWalker2_validate;miRNATAP -0.236304247402631 7.89060052559466e-06 NA NA NA hsa-miR-22-5p FOXP1 1.88011544159252 1.63978222572222e-16 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.182705348664276 1.0677123157684e-06 NA NA NA hsa-miR-221-3p FOXP1 0.451556679024397 0.0909808299917811 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.127003829921659 0.000135915176379606 NA NA NA hsa-miR-222-3p FOXP1 0.851783756239071 0.00266783568486918 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.160987802733223 2.04310036487173e-07 NA NA NA hsa-miR-23a-3p FOXP1 1.00493340843378 2.55313889288924e-08 -0.873044719534777 1.61392354745552e-06 mirMAP -0.180763197824306 0.000223683877592435 NA NA NA hsa-miR-29a-5p FOXP1 1.46749674755271 3.34605004270294e-07 -0.873044719534777 1.61392354745552e-06 mirMAP -0.155972859837073 1.14553198557374e-06 NA NA NA hsa-miR-301a-3p FOXP1 2.81024345929638 2.29784847962242e-17 -0.873044719534777 1.61392354745552e-06 mirMAP -0.175091047386777 5.71987341851838e-11 NA NA NA hsa-miR-32-5p FOXP1 2.34056473219422 6.24134585974322e-20 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.116324049649243 0.000458470933850409 NA NA NA hsa-miR-324-5p FOXP1 2.95683728155095 1.32960514360912e-20 -0.873044719534777 1.61392354745552e-06 miRanda -0.142861294406791 6.00580720556075e-08 NA NA NA hsa-miR-339-5p FOXP1 2.68710938429893 3.03134080808154e-16 -0.873044719534777 1.61392354745552e-06 PITA -0.162773852676037 2.01059044158839e-10 NA NA NA hsa-miR-33a-5p FOXP1 3.79671563098419 1.15966309820345e-18 -0.873044719534777 1.61392354745552e-06 miRNAWalker2_validate -0.107848821102866 4.1667732269223e-07 NA NA NA hsa-miR-340-5p FOXP1 0.30282999308409 0.157744789519131 -0.873044719534777 1.61392354745552e-06 mirMAP -0.148110617466208 0.00038861304596097 NA NA NA hsa-miR-34c-3p FOXP1 2.41359195938096 3.46966584087088e-10 -0.873044719534777 1.61392354745552e-06 PITA;miRNATAP -0.104664563677677 7.07915549284934e-06 NA NA NA hsa-miR-3607-3p FOXP1 2.68532138541128 5.66716351955047e-14 -0.873044719534777 1.61392354745552e-06 mirMAP;miRNATAP -0.13591918803838 2.7522650555888e-08 NA NA NA hsa-miR-3613-5p FOXP1 2.64358387329263 1.0373753017245e-24 -0.873044719534777 1.61392354745552e-06 mirMAP -0.136926523226267 4.15133394632172e-05 NA NA NA hsa-miR-421 FOXP1 1.17791565395543 6.78526676976629e-06 -0.873044719534777 1.61392354745552e-06 miRanda;miRNATAP -0.116782694841344 0.000544493752846523 NA NA NA hsa-miR-454-3p FOXP1 2.47234127820054 1.12878018736016e-21 -0.873044719534777 1.61392354745552e-06 mirMAP -0.194472076889014 4.73977563176244e-09 NA NA NA hsa-miR-500a-5p FOXP1 1.72110365584658 3.0807246212659e-10 -0.873044719534777 1.61392354745552e-06 MirTarget -0.158336133932135 5.69184215240902e-07 NA NA NA hsa-miR-532-3p FOXP1 1.96631878320218 4.53421954361695e-13 -0.873044719534777 1.61392354745552e-06 PITA;miRNATAP -0.167136479536779 1.16154402221587e-07 NA NA NA hsa-miR-576-5p FOXP1 2.20467023993664 3.4053475193793e-19 -0.873044719534777 1.61392354745552e-06 mirMAP -0.22858072652845 1.67711951216164e-11 NA NA NA hsa-miR-590-3p FOXP1 2.59289455139753 1.03200520972022e-21 -0.873044719534777 1.61392354745552e-06 PITA;miRanda;mirMAP;miRNATAP -0.197343407274016 4.13118184648718e-10 NA NA NA hsa-miR-590-5p FOXP1 3.18300989862077 2.06813568597893e-26 -0.873044719534777 1.61392354745552e-06 PITA;miRanda;mirMAP -0.20726999976325 1.15520186074632e-13 NA NA NA hsa-miR-624-5p FOXP1 1.47043111118159 8.25080691741182e-09 -0.873044719534777 1.61392354745552e-06 MirTarget -0.125511149358415 0.000430388189300988 NA NA NA hsa-miR-628-5p FOXP1 0.799263053510813 2.28892357418044e-05 -0.873044719534777 1.61392354745552e-06 PITA -0.234545125687263 5.57168524618317e-07 NA NA NA hsa-miR-671-5p FOXP1 2.97733652243246 1.21148452344738e-23 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.170424895534095 8.02138301215849e-09 NA NA NA hsa-miR-7-1-3p FOXP1 1.84950311431067 1.25300363397654e-13 -0.873044719534777 1.61392354745552e-06 mirMAP -0.181129746794879 1.32245486971465e-07 NA NA NA hsa-miR-769-3p FOXP1 2.19896922202687 5.69250370895053e-12 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.127271515867413 4.72500967492743e-06 NA NA NA hsa-miR-92a-3p FOXP1 2.06460102658973 1.44784291084757e-19 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.244750350708352 2.49937303923007e-11 NA NA NA hsa-miR-92b-3p FOXP1 1.20409245530001 3.41055816361655e-06 -0.873044719534777 1.61392354745552e-06 miRNATAP -0.214755545443339 1.29779099449285e-10 NA NA NA hsa-miR-18a-3p GATA2 2.14813400940323 2.23460809936028e-06 -0.151531352496005 0.720830977548444 miRNATAP -0.223338866954425 6.90239384226702e-05 NA NA NA hsa-miR-193a-3p GATA2 1.60460546928078 2.86169793322984e-07 -0.151531352496005 0.720830977548444 miRanda -0.292864346999512 5.14273595929449e-06 NA NA NA hsa-miR-212-3p GATA2 0.357878936470387 0.232446214501331 -0.151531352496005 0.720830977548444 miRNATAP -0.352783007872596 2.32784426140657e-07 NA NA NA hsa-miR-27a-3p GATA2 1.66542180327138 4.93775737894805e-13 -0.151531352496005 0.720830977548444 MirTarget;miRNATAP -0.451164031833464 1.51835235869011e-07 NA NA NA hsa-miR-338-5p GATA2 -0.577691606146419 0.0472212680542825 -0.151531352496005 0.720830977548444 MirTarget;PITA;miRNATAP -0.205343589481228 0.00387528254839555 NA NA NA hsa-miR-409-3p GATA2 0.877551657794358 0.00171210686733898 -0.151531352496005 0.720830977548444 MirTarget;PITA;miRNATAP -0.258234172676383 0.000399349998275437 NA NA NA hsa-miR-493-5p GATA2 0.847772103665986 0.00528678068747754 -0.151531352496005 0.720830977548444 MirTarget;miRNATAP -0.264626331904468 8.37948760760405e-05 NA NA NA hsa-miR-496 GATA2 0.46914638405371 0.145980484291736 -0.151531352496005 0.720830977548444 miRanda -0.172453795836123 0.00805706809342451 NA NA NA hsa-miR-590-3p GATA2 2.59289455139753 1.03200520972022e-21 -0.151531352496005 0.720830977548444 miRanda -0.15141670784217 0.0414337582614947 NA NA NA hsa-miR-92b-3p GATA2 1.20409245530001 3.41055816361655e-06 -0.151531352496005 0.720830977548444 MirTarget;miRNATAP -0.391417939178601 4.69569020112441e-07 NA NA NA hsa-miR-106b-5p GNA11 2.46782146831112 1.36171495805632e-23 -0.661701785677749 0.00036434655636847 mirMAP -0.166698759306213 1.28404205520557e-06 NA NA NA hsa-miR-140-3p GNA11 0.0608890720479334 0.727716871248724 -0.661701785677749 0.00036434655636847 mirMAP -0.221986586407059 2.04773852370797e-05 NA NA NA hsa-miR-20a-5p GNA11 3.15577933619191 4.19753346442454e-25 -0.661701785677749 0.00036434655636847 mirMAP -0.111745204789157 5.67635330453463e-05 NA NA NA hsa-miR-330-3p GNA11 0.876747334239085 0.00073709016089703 -0.661701785677749 0.00036434655636847 mirMAP -0.148716814068229 1.59808072537076e-05 NA NA NA hsa-miR-342-5p GNA11 1.74634624752902 3.89286511372155e-11 -0.661701785677749 0.00036434655636847 mirMAP -0.165630044601705 5.82679559161001e-07 NA NA NA hsa-miR-362-3p GNA11 2.0756816987665 3.89026064579331e-12 -0.661701785677749 0.00036434655636847 miRanda -0.11185531153562 0.000224458812504752 NA NA NA hsa-miR-3913-5p GNA11 2.44353493655328 8.95279496632448e-15 -0.661701785677749 0.00036434655636847 mirMAP -0.142481345157138 4.55988683999396e-07 NA NA NA hsa-miR-450b-5p GNA11 1.69244418548325 1.68064054148881e-10 -0.661701785677749 0.00036434655636847 mirMAP -0.102289862078318 0.00218300337150116 NA NA NA hsa-miR-484 GNA11 1.81844463411787 1.82951571230938e-15 -0.661701785677749 0.00036434655636847 mirMAP -0.191373723661752 4.4986285017252e-07 NA NA NA hsa-miR-505-3p GNA11 1.45322244209148 8.86597629645867e-10 -0.661701785677749 0.00036434655636847 mirMAP -0.145152679244327 0.000100493302063982 NA NA NA hsa-miR-629-5p GNA11 2.10182419359635 1.51788571125757e-15 -0.661701785677749 0.00036434655636847 mirMAP -0.106046675562493 0.00135852165229471 NA NA NA hsa-miR-671-5p GNA11 2.97733652243246 1.21148452344738e-23 -0.661701785677749 0.00036434655636847 mirMAP -0.134580280389055 8.28546976211434e-06 NA NA NA hsa-miR-93-5p GNA11 3.03961860136032 1.11672209617395e-24 -0.661701785677749 0.00036434655636847 mirMAP -0.131151400161785 4.23129141311573e-06 NA NA NA hsa-miR-96-5p GNA11 4.89433085814374 1.92000659886961e-31 -0.661701785677749 0.00036434655636847 TargetScan -0.100318860607412 7.14799558874877e-07 NA NA NA hsa-miR-107 GREM1 1.30977326593435 1.30372468603965e-11 0.08752650759248 0.914525538097529 miRanda -1.37810741656521 2.02758217319007e-12 NA NA NA hsa-miR-10b-3p GREM1 0.77597971642517 0.00264877454133753 0.08752650759248 0.914525538097529 MirTarget -1.36852159609299 6.23271757645556e-21 NA NA NA hsa-miR-128-3p GREM1 1.63756041666078 6.79626586407187e-14 0.08752650759248 0.914525538097529 MirTarget -1.13422279076679 4.85325219373668e-11 NA NA NA hsa-miR-129-5p GREM1 -0.524170159980738 0.222582956006346 0.08752650759248 0.914525538097529 mirMAP -0.471227080343252 3.52117281319331e-07 NA NA NA hsa-miR-151a-3p GREM1 1.24018761527407 1.08839919675408e-07 0.08752650759248 0.914525538097529 MirTarget -1.58222563926787 2.02841814242008e-23 NA NA NA hsa-miR-15b-3p GREM1 2.33847028227712 4.29662877950836e-19 0.08752650759248 0.914525538097529 mirMAP -0.819842990848174 8.43287080175706e-09 NA NA NA hsa-miR-181c-5p GREM1 1.58587920618301 1.57506918816933e-10 0.08752650759248 0.914525538097529 MirTarget -0.503571678139943 0.00124981890133994 NA NA NA hsa-miR-181d-5p GREM1 1.52204912185579 9.2693319057748e-08 0.08752650759248 0.914525538097529 MirTarget -0.447647485490356 0.00104202641429586 NA NA NA hsa-miR-186-5p GREM1 1.47445398888668 3.0781726595413e-15 0.08752650759248 0.914525538097529 mirMAP -1.09586475549989 7.29953165734902e-08 NA NA NA hsa-miR-200b-3p GREM1 3.78235093249346 3.18343003239465e-14 0.08752650759248 0.914525538097529 MirTarget -0.579405660626665 5.36921677424216e-15 NA NA NA hsa-miR-200c-3p GREM1 3.50132673580082 2.42716349086937e-15 0.08752650759248 0.914525538097529 MirTarget -0.651094007307394 5.51115376486247e-15 NA NA NA hsa-miR-30d-3p GREM1 0.977747550180601 4.3048212205381e-05 0.08752650759248 0.914525538097529 MirTarget -1.52172277523851 2.57374182547526e-22 NA NA NA hsa-miR-30e-3p GREM1 -0.215663037684509 0.235375122783546 0.08752650759248 0.914525538097529 MirTarget -1.87248543784311 7.38237263621522e-19 NA NA NA hsa-miR-32-3p GREM1 2.02436999565685 5.94091197945307e-09 0.08752650759248 0.914525538097529 mirMAP -0.811892755821005 6.93218407387058e-11 NA NA NA hsa-miR-330-3p GREM1 0.876747334239085 0.00073709016089703 0.08752650759248 0.914525538097529 mirMAP -1.05010076920601 1.23653879596895e-12 NA NA NA hsa-miR-3614-5p GREM1 2.17736331059655 2.19144831318484e-08 0.08752650759248 0.914525538097529 MirTarget -0.219496167117674 0.03372410342964 NA NA NA hsa-miR-3653-3p GREM1 1.85886928622326 2.98407490336841e-08 0.08752650759248 0.914525538097529 MirTarget -0.528754440768381 1.39914241513161e-05 NA NA NA hsa-miR-374a-3p GREM1 0.533309330504947 0.00192918429705142 0.08752650759248 0.914525538097529 mirMAP -0.571879085427857 0.0137452846486805 NA NA NA hsa-miR-429 GREM1 4.48815175680773 2.44117492218206e-17 0.08752650759248 0.914525538097529 MirTarget;miRanda -0.503437531755623 4.25141486107767e-13 NA NA NA hsa-miR-484 GREM1 1.81844463411787 1.82951571230938e-15 0.08752650759248 0.914525538097529 PITA -0.772943992081722 3.27500357761039e-06 NA NA NA hsa-miR-576-5p GREM1 2.20467023993664 3.4053475193793e-19 0.08752650759248 0.914525538097529 mirMAP -0.586644183254509 0.000128451300339467 NA NA NA hsa-miR-664a-3p GREM1 0.634721925861133 0.00520070178640421 0.08752650759248 0.914525538097529 mirMAP -1.25554376789919 1.28137929925914e-13 NA NA NA hsa-miR-944 GREM1 2.91186649218281 1.31574753528144e-06 0.08752650759248 0.914525538097529 mirMAP -0.306629317082103 3.55297790645169e-06 NA NA NA hsa-miR-139-5p GSK3B -1.52606598644743 1.20474151350665e-08 0.406268283461383 0.000508906658360755 mirMAP -0.100160771461377 1.20519675407331e-06 NA NA NA hsa-miR-98-5p IFNGR1 1.11154309866014 1.24143909012085e-08 -0.152461512869484 0.415720660028279 miRNAWalker2_validate -0.214203997627061 2.63521831579226e-06 NA NA NA hsa-let-7d-5p IGF1R 1.33236798905207 1.1741085658466e-13 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;MirTarget;miRNATAP -0.233908899420042 0.000276801000319017 25287248 Focusing on the let-7d-5p/3p pair the respectively targeted IGF1R and KRAS were shown to be in a reverse relationship with expression of the respective miRNA which was confirmed in transient transfection assays using let-7d mimic or inhibitor; Targeting of KRAS by let-7d was previous reported; targeting of IGF1R by let-7d-5p was confirmed in luciferase assays in this study colon cancer hsa-let-7g-5p IGF1R 1.20061455355116 1.50237505511483e-12 -0.486024248749606 0.0460954581792042 MirTarget;miRNATAP -0.302735983859819 8.9121124787433e-06 NA NA NA hsa-let-7i-5p IGF1R 0.412877696970403 0.00622731051981756 -0.486024248749606 0.0460954581792042 MirTarget;miRNATAP -0.228891222780098 0.00403501843356413 NA NA NA hsa-miR-1226-3p IGF1R 1.38118928579963 0.000205503474787488 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.10824109893534 0.00264508157056216 NA NA NA hsa-miR-1306-3p IGF1R 1.7835592527682 5.37873730566685e-08 -0.486024248749606 0.0460954581792042 mirMAP -0.140508877717541 0.000219830668957512 NA NA NA hsa-miR-140-3p IGF1R 0.0608890720479334 0.727716871248724 -0.486024248749606 0.0460954581792042 mirMAP -0.27831144732677 4.48014718263299e-05 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-140-5p IGF1R 0.844753502512594 3.73722278438606e-05 -0.486024248749606 0.0460954581792042 PITA;miRNATAP -0.210132849945263 0.000252820917193275 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-148a-5p IGF1R 1.16173838132242 0.000148929299881612 -0.486024248749606 0.0460954581792042 mirMAP -0.153273555432878 5.76643013870475e-05 NA NA NA hsa-miR-155-5p IGF1R 1.20164021433135 0.00086170622431261 -0.486024248749606 0.0460954581792042 mirMAP -0.109822477719586 0.000717019910707966 NA NA NA hsa-miR-15a-5p IGF1R 2.34669284378787 1.69544424500258e-23 -0.486024248749606 0.0460954581792042 miRNATAP -0.166867754420311 0.000454880786472648 NA NA NA hsa-miR-15b-3p IGF1R 2.33847028227712 4.29662877950836e-19 -0.486024248749606 0.0460954581792042 mirMAP -0.138682202682081 0.00131010066932468 NA NA NA hsa-miR-15b-5p IGF1R 1.57112623124278 9.14247846750597e-13 -0.486024248749606 0.0460954581792042 miRNATAP -0.248371255379639 1.81573519572013e-06 NA NA NA hsa-miR-16-1-3p IGF1R 2.56983217111073 3.02262181237943e-20 -0.486024248749606 0.0460954581792042 mirMAP -0.106436020324207 0.0104914815995738 NA NA NA hsa-miR-16-5p IGF1R 1.75824877145857 1.68592440033108e-16 -0.486024248749606 0.0460954581792042 miRNATAP -0.185976273412055 0.000509431308521588 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-185-5p IGF1R 2.34016206907488 1.17481626642022e-26 -0.486024248749606 0.0460954581792042 MirTarget -0.210347183440742 3.18341012357928e-05 NA NA NA hsa-miR-186-5p IGF1R 1.47445398888668 3.0781726595413e-15 -0.486024248749606 0.0460954581792042 mirMAP -0.259580928228016 2.27679515390945e-05 NA NA NA hsa-miR-192-5p IGF1R 2.69002528723195 1.22990188194432e-16 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.162071899497905 2.95566440166205e-06 NA NA NA hsa-miR-193a-5p IGF1R 0.562511612963676 0.0239254699649222 -0.486024248749606 0.0460954581792042 mirMAP -0.135722188768563 0.00426871718315317 NA NA NA hsa-miR-194-5p IGF1R 1.8992998339217 3.76507853301977e-10 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.188748374877298 5.71579919612031e-07 NA NA NA hsa-miR-195-5p IGF1R -1.44753678070504 8.70594292149271e-09 -0.486024248749606 0.0460954581792042 miRNATAP -0.138117817160811 0.00280989255838415 NA NA NA hsa-miR-197-3p IGF1R 1.75733174019505 8.88576793100499e-13 -0.486024248749606 0.0460954581792042 mirMAP -0.184182858103751 7.83269013421259e-05 NA NA NA hsa-miR-19a-3p IGF1R 3.42309334186656 3.02671914353412e-28 -0.486024248749606 0.0460954581792042 mirMAP -0.10754867299782 0.00243372140663191 NA NA NA hsa-miR-215-5p IGF1R 2.30755467422978 2.38476032118039e-06 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.142175668265091 3.8628174812409e-09 NA NA NA hsa-miR-29b-2-5p IGF1R 0.910668640983475 0.00666655585493488 -0.486024248749606 0.0460954581792042 mirMAP -0.119177500662335 0.000665741966203079 NA NA NA hsa-miR-29c-3p IGF1R -0.00968972577705429 0.97099586346872 -0.486024248749606 0.0460954581792042 mirMAP -0.157172588392593 0.000394988588911287 NA NA NA hsa-miR-30b-5p IGF1R 0.800822374912712 0.000133601914525413 -0.486024248749606 0.0460954581792042 mirMAP -0.136790931346952 0.0153105823842772 NA NA NA hsa-miR-30c-5p IGF1R 0.778774633108 0.000285599212429136 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.215080796493845 8.67590028266986e-05 NA NA NA hsa-miR-30d-5p IGF1R 0.675423997639582 0.00270618816039773 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.133794093695246 0.0109379152026071 NA NA NA hsa-miR-30e-5p IGF1R 1.23904909539663 1.35561917122157e-09 -0.486024248749606 0.0460954581792042 mirMAP -0.224447576166182 7.77702491429068e-05 NA NA NA hsa-miR-331-5p IGF1R 2.17414714166315 1.54547681391888e-18 -0.486024248749606 0.0460954581792042 PITA -0.102078651683119 0.0306115892779405 NA NA NA hsa-miR-339-5p IGF1R 2.68710938429893 3.03134080808154e-16 -0.486024248749606 0.0460954581792042 miRanda -0.120536510471461 0.000473712630520207 NA NA NA hsa-miR-342-3p IGF1R 1.49115144672245 1.43879249744621e-07 -0.486024248749606 0.0460954581792042 mirMAP -0.127400630242107 0.00191533765474422 NA NA NA hsa-miR-342-5p IGF1R 1.74634624752902 3.89286511372155e-11 -0.486024248749606 0.0460954581792042 mirMAP -0.17222881544086 7.73422132892045e-05 NA NA NA hsa-miR-3613-5p IGF1R 2.64358387329263 1.0373753017245e-24 -0.486024248749606 0.0460954581792042 mirMAP;miRNATAP -0.125077117428257 0.0049529824143567 NA NA NA hsa-miR-362-3p IGF1R 2.0756816987665 3.89026064579331e-12 -0.486024248749606 0.0460954581792042 PITA -0.206769365293673 1.43775490045472e-07 NA NA NA hsa-miR-3677-3p IGF1R 1.55935355925312 4.80239289905323e-06 -0.486024248749606 0.0460954581792042 MirTarget -0.175911681444773 2.01649902650337e-07 NA NA NA hsa-miR-374a-5p IGF1R 0.484615721953736 0.0042981729815149 -0.486024248749606 0.0460954581792042 mirMAP -0.234001149935664 0.000864680357370787 NA NA NA hsa-miR-374b-5p IGF1R 0.0654362503857184 0.722673188879465 -0.486024248749606 0.0460954581792042 mirMAP -0.260316989857322 5.53324694472522e-05 NA NA NA hsa-miR-378a-5p IGF1R 0.223456081148306 0.386368843153575 -0.486024248749606 0.0460954581792042 mirMAP -0.127780003468782 0.0054319364150493 24119742;25427715 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS ; liver cancer;sarcoma hsa-miR-3913-5p IGF1R 2.44353493655328 8.95279496632448e-15 -0.486024248749606 0.0460954581792042 mirMAP -0.126397785568049 0.000687296309514575 NA NA NA hsa-miR-409-5p IGF1R 1.56949123847358 5.91654175754272e-07 -0.486024248749606 0.0460954581792042 PITA -0.104622478580007 0.00774804832597773 NA NA NA hsa-miR-421 IGF1R 1.17791565395543 6.78526676976629e-06 -0.486024248749606 0.0460954581792042 miRanda -0.179133195485579 6.03309149743434e-05 NA NA NA hsa-miR-484 IGF1R 1.81844463411787 1.82951571230938e-15 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.282538218482723 1.04528421031889e-08 NA NA NA hsa-miR-495-3p IGF1R -0.0847115949846082 0.763475496144456 -0.486024248749606 0.0460954581792042 mirMAP -0.119947784452941 0.00444753291132263 NA NA NA hsa-miR-497-5p IGF1R 0.0257087130056286 0.918145413833358 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate;miRTarBase;miRNATAP -0.152362590794185 0.00129782502934878 NA NA NA hsa-miR-500a-3p IGF1R 1.47161373123699 5.30571342631915e-09 -0.486024248749606 0.0460954581792042 mirMAP -0.308758568854319 7.46172041584498e-12 NA NA NA hsa-miR-532-5p IGF1R 1.55697650978597 1.57884735535196e-11 -0.486024248749606 0.0460954581792042 miRNATAP -0.305954968906114 5.01442184672658e-10 NA NA NA hsa-miR-542-3p IGF1R 1.18832665895751 1.98700670691565e-07 -0.486024248749606 0.0460954581792042 mirMAP -0.150251984416169 0.00332990570749663 NA NA NA hsa-miR-592 IGF1R 1.51765968871077 0.000636335248013204 -0.486024248749606 0.0460954581792042 PITA;miRNATAP -0.124822698210919 2.83708994200769e-06 NA NA NA hsa-miR-625-5p IGF1R 1.42540152147292 1.95797147911206e-06 -0.486024248749606 0.0460954581792042 MirTarget -0.148113785343487 0.000526615821219427 NA NA NA hsa-miR-664a-5p IGF1R 0.505019913598436 0.032933350691651 -0.486024248749606 0.0460954581792042 mirMAP -0.11199698919234 0.0260197126075394 NA NA NA hsa-miR-671-5p IGF1R 2.97733652243246 1.21148452344738e-23 -0.486024248749606 0.0460954581792042 mirMAP -0.129839479602332 0.00106882467611499 NA NA NA hsa-miR-7-1-3p IGF1R 1.84950311431067 1.25300363397654e-13 -0.486024248749606 0.0460954581792042 mirMAP -0.170630021804943 0.00020010536359991 NA NA NA hsa-miR-877-5p IGF1R 2.94916202082736 1.8151927276044e-13 -0.486024248749606 0.0460954581792042 MirTarget -0.105351058260924 0.00105209735401847 NA NA NA hsa-miR-92a-3p IGF1R 2.06460102658973 1.44784291084757e-19 -0.486024248749606 0.0460954581792042 miRNAWalker2_validate -0.114848306889288 0.0209529487137771 NA NA NA hsa-miR-940 IGF1R 3.21011374578759 2.7923171128495e-14 -0.486024248749606 0.0460954581792042 mirMAP -0.112078867143816 0.000138658602668637 NA NA NA hsa-miR-98-5p IGF1R 1.11154309866014 1.24143909012085e-08 -0.486024248749606 0.0460954581792042 MirTarget -0.310419335327057 1.6607359063192e-07 NA NA NA hsa-miR-99b-5p IGF1R 0.814286288944185 0.000299800699512742 -0.486024248749606 0.0460954581792042 miRNATAP -0.14193096371114 0.00677531758993343 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-125a-5p IL7R 0.599529391575274 0.0102300147180307 -1.05033388888472 0.0658543700402536 miRanda -0.70343309526522 1.80486059514543e-09 NA NA NA hsa-miR-129-5p IL7R -0.524170159980738 0.222582956006346 -1.05033388888472 0.0658543700402536 miRanda;mirMAP -0.159763515609224 0.0149914100365471 NA NA NA hsa-miR-181c-5p IL7R 1.58587920618301 1.57506918816933e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.496371141599136 5.05532021358559e-06 NA NA NA hsa-miR-26b-5p IL7R 0.885393662798425 3.2116297961629e-06 -1.05033388888472 0.0658543700402536 miRNAWalker2_validate -0.309468489953212 0.0338128004203917 NA NA NA hsa-miR-3065-5p IL7R 2.74629919868982 1.86846589298284e-08 -1.05033388888472 0.0658543700402536 mirMAP -0.303894968324891 7.17685947412129e-06 NA NA NA hsa-miR-330-3p IL7R 0.876747334239085 0.00073709016089703 -1.05033388888472 0.0658543700402536 miRNATAP -0.503498227571291 1.78992992142017e-06 NA NA NA hsa-miR-335-3p IL7R 3.08791651139852 5.31309869723517e-12 -1.05033388888472 0.0658543700402536 mirMAP -0.274186508929196 4.22202008391783e-06 NA NA NA hsa-miR-450b-5p IL7R 1.69244418548325 1.68064054148881e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.225810857440466 0.0278018805715008 NA NA NA hsa-miR-501-5p IL7R 1.93654809410041 1.3779381780759e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.280190017844517 0.00242876728641734 NA NA NA hsa-miR-508-3p IL7R 1.05493034310846 0.0393857095042515 -1.05033388888472 0.0658543700402536 mirMAP -0.141480471119692 0.0102247623467109 NA NA NA hsa-miR-576-5p IL7R 2.20467023993664 3.4053475193793e-19 -1.05033388888472 0.0658543700402536 mirMAP -0.425928935231224 7.31668657168399e-05 NA NA NA hsa-miR-7-1-3p IL7R 1.84950311431067 1.25300363397654e-13 -1.05033388888472 0.0658543700402536 mirMAP -0.311333751551424 0.00392955547080483 NA NA NA hsa-let-7b-3p INPP4A 0.868207752019623 1.30460056774366e-05 -0.310694170430495 0.126958228506836 mirMAP -0.225673106698171 4.16075272531161e-06 NA NA NA hsa-miR-146b-5p INPP4A 1.75587235896724 1.15724631266659e-07 -0.310694170430495 0.126958228506836 miRanda -0.106601071258574 0.00025809657215931 NA NA NA hsa-miR-34c-5p INPP4A 2.07190852984647 7.35776320806257e-08 -0.310694170430495 0.126958228506836 miRanda -0.173162298157221 4.50561141337293e-11 NA NA NA hsa-miR-148b-5p INPP4B 2.18024067300781 2.84770452413262e-14 0.571665841429498 0.1089983734371 MirTarget -0.182990230972066 0.00306061572136636 NA NA NA hsa-miR-15b-3p INPP4B 2.33847028227712 4.29662877950836e-19 0.571665841429498 0.1089983734371 mirMAP -0.159429064685886 0.0117971701716695 NA NA NA hsa-miR-186-5p INPP4B 1.47445398888668 3.0781726595413e-15 0.571665841429498 0.1089983734371 mirMAP -0.299093902993575 0.000897387055939049 NA NA NA hsa-miR-338-5p INPP4B -0.577691606146419 0.0472212680542825 0.571665841429498 0.1089983734371 mirMAP;miRNATAP -0.148651915742837 0.01316373545612 NA NA NA hsa-miR-340-5p INPP4B 0.30282999308409 0.157744789519131 0.571665841429498 0.1089983734371 mirMAP -0.419046411500796 1.80242755618156e-07 NA NA NA hsa-miR-374a-5p INPP4B 0.484615721953736 0.0042981729815149 0.571665841429498 0.1089983734371 mirMAP -0.402556893879913 8.66546360871134e-05 NA NA NA hsa-miR-374b-5p INPP4B 0.0654362503857184 0.722673188879465 0.571665841429498 0.1089983734371 mirMAP -0.441056062979778 2.83136791088548e-06 NA NA NA hsa-miR-590-3p INPP4B 2.59289455139753 1.03200520972022e-21 0.571665841429498 0.1089983734371 MirTarget;miRanda;mirMAP -0.18489101593983 0.00303044951660273 NA NA NA hsa-miR-590-5p INPP4B 3.18300989862077 2.06813568597893e-26 0.571665841429498 0.1089983734371 miRanda;mirMAP -0.1261994823752 0.0236943474887476 NA NA NA hsa-let-7a-3p INSR 1.42015538786275 7.03375209382654e-13 -0.335737111104281 0.0754278446119288 mirMAP -0.15816973369539 0.000461473183490821 NA NA NA hsa-let-7b-3p INSR 0.868207752019623 1.30460056774366e-05 -0.335737111104281 0.0754278446119288 mirMAP -0.18259237309381 6.27697448618197e-05 NA NA NA hsa-let-7f-1-3p INSR 1.55054488387679 7.31326775537952e-11 -0.335737111104281 0.0754278446119288 mirMAP -0.234879100967927 6.9044840520178e-10 NA NA NA hsa-let-7i-5p INSR 0.412877696970403 0.00622731051981756 -0.335737111104281 0.0754278446119288 miRNATAP -0.341000101339301 1.99898841669127e-08 NA NA NA hsa-miR-127-5p INSR 1.19850695520181 4.10976607177645e-05 -0.335737111104281 0.0754278446119288 PITA -0.114659842304268 0.000209322472841496 NA NA NA hsa-miR-142-5p INSR 1.17581605694506 0.0018174701991234 -0.335737111104281 0.0754278446119288 mirMAP -0.184533831964077 2.57101036960177e-15 NA NA NA hsa-miR-21-5p INSR 2.73773305747971 1.38864982139576e-43 -0.335737111104281 0.0754278446119288 mirMAP -0.288296420322576 1.5840822983789e-12 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-27a-3p INSR 1.66542180327138 4.93775737894805e-13 -0.335737111104281 0.0754278446119288 miRNATAP -0.257598888912134 9.95729032473756e-12 NA NA NA hsa-miR-342-3p INSR 1.49115144672245 1.43879249744621e-07 -0.335737111104281 0.0754278446119288 miRanda -0.173236629545461 3.38807506976711e-08 NA NA NA hsa-miR-424-5p INSR 1.61930224569578 1.89642549274994e-10 -0.335737111104281 0.0754278446119288 miRNATAP -0.111271098127559 0.0015781856467318 NA NA NA hsa-miR-590-3p INSR 2.59289455139753 1.03200520972022e-21 -0.335737111104281 0.0754278446119288 PITA;miRanda;mirMAP;miRNATAP -0.109443531364485 0.000887859920453394 NA NA NA hsa-miR-107 IRF4 1.30977326593435 1.30372468603965e-11 -1.72341587118467 0.000316270812550294 miRanda -0.597431945824905 3.6416212687405e-07 NA NA NA hsa-miR-125a-5p IRF4 0.599529391575274 0.0102300147180307 -1.72341587118467 0.000316270812550294 miRanda -0.482979940044598 1.14539777186886e-06 NA NA NA hsa-miR-129-5p IRF4 -0.524170159980738 0.222582956006346 -1.72341587118467 0.000316270812550294 miRanda;mirMAP -0.15446057409937 0.00520412213629927 NA NA NA hsa-miR-148b-5p IRF4 2.18024067300781 2.84770452413262e-14 -1.72341587118467 0.000316270812550294 mirMAP -0.377150318082848 5.29636315166118e-06 NA NA NA hsa-miR-186-5p IRF4 1.47445398888668 3.0781726595413e-15 -1.72341587118467 0.000316270812550294 mirMAP -0.401557034663767 0.000960579414066743 NA NA NA hsa-miR-3065-5p IRF4 2.74629919868982 1.86846589298284e-08 -1.72341587118467 0.000316270812550294 mirMAP -0.276682246419021 1.17733702774817e-06 NA NA NA hsa-miR-30c-5p IRF4 0.778774633108 0.000285599212429136 -1.72341587118467 0.000316270812550294 miRNATAP -0.28321081811481 0.00927497946081463 NA NA NA hsa-miR-30d-5p IRF4 0.675423997639582 0.00270618816039773 -1.72341587118467 0.000316270812550294 miRNATAP -0.659985205974574 8.83612798275054e-11 NA NA NA hsa-miR-320a IRF4 0.438165828017084 0.0390159073347133 -1.72341587118467 0.000316270812550294 miRanda -0.430120346050225 9.40532306320003e-05 NA NA NA hsa-miR-320b IRF4 1.55692969039548 1.41071034251915e-08 -1.72341587118467 0.000316270812550294 miRanda -0.441405889676576 9.4061754637072e-08 NA NA NA hsa-miR-330-3p IRF4 0.876747334239085 0.00073709016089703 -1.72341587118467 0.000316270812550294 mirMAP -0.354433701959812 7.09169909241445e-05 NA NA NA hsa-miR-421 IRF4 1.17791565395543 6.78526676976629e-06 -1.72341587118467 0.000316270812550294 miRanda;mirMAP -0.320816214771673 0.000284572882356 NA NA NA hsa-miR-429 IRF4 4.48815175680773 2.44117492218206e-17 -1.72341587118467 0.000316270812550294 miRanda -0.332829415686506 3.02252383248622e-16 NA NA NA hsa-miR-491-5p IRF4 0.615770352820862 0.0418295628761654 -1.72341587118467 0.000316270812550294 miRanda -0.22725260463814 0.00600202803220141 NA NA NA hsa-miR-589-3p IRF4 2.51971841868825 2.39125940264107e-11 -1.72341587118467 0.000316270812550294 mirMAP -0.239578266041313 0.000469671788504733 NA NA NA hsa-miR-126-3p IRS1 1.6384689127743 1.4473425456641e-10 -0.851786005843366 0.00822245753156005 miRNAWalker2_validate;miRTarBase;miRNATAP -0.288428290430461 1.25837179330996e-06 24312276;23981989;26893720 Down regulation of miR 126 is associated with colorectal cancer cells proliferation migration and invasion by targeting IRS 1 via the AKT and ERK1/2 signaling pathways; In this study we identified the potential effects of miR-126 on some important biological properties of CRC cells and clarified the regulation of insulin receptor substrate 1 IRS-1 and its possible signaling pathway by miR-126; The 3'-untranslated region 3'-UTR of IRS-1 regulated by miR-126 was analyzed by using a dual-luciferase reporter assay; We found that IRS-1 is the functional downstream target of miR-126 by directly targeting the 3'-UTR of IRS-1; Endogenous miR-126 and exogenous miR-126 mimic inhibited IRS-1 expression; Furthermore gain-of-function or loss-of-function studies showed that over-expression of miR-126 down-regulated IRS-1 suppressed AKT and ERK1/2 activation CRC cells proliferation migration invasion and caused cell cycle arrest but had no effect on cell apoptosis; Knockdown of miR-126 promoted these processes in HCT-116 cells and promoted AKT and ERK1/2 activation by up-regulating the expression of the IRS-1 protein; MiR-126 may play roles in regulation of the biological behavior of CRC cells at least in part by targeting IRS-1 via AKT and ERK1/2 signaling pathways;It has been shown that IRS1 SLC75A and TOM1 were the potential target genes of miR-126 in colon cancer;Molecular mechanism investigation established that insulin receptor substrate 1 IRS1 functioned as a direct miR-126 target and its expression was negatively regulated by miR-126 at a post-transcriptional level in the SKOV3 cells; Additionally the overexpression of IRS1 reversed the inhibitory effect of miR-126 overexpression on SKOV3 cell migration and invasion; In conclusion the current study demonstrated that miR-126 inhibited EC cell migration and invasion at least partially through the direct targeting of IRS1 suggesting that miR-126 may aid the treatment of EC metastasis ;;cell migration;metastasis colorectal cancer;colon cancer;endometrial cancer hsa-miR-1271-5p IRS1 0.970418832993172 0.000609742584380688 -0.851786005843366 0.00822245753156005 MirTarget -0.121619255600699 0.0278675997772774 NA NA NA hsa-miR-128-3p IRS1 1.63756041666078 6.79626586407187e-14 -0.851786005843366 0.00822245753156005 MirTarget -0.230857412063909 0.000928301106826369 26352220 In addition insulin receptor substrate 1 IRS1 a key mediator in oncogenic insulin-like growth factor IGF signaling was confirmed as a direct target of miR-128 by a luciferase reporter assay; Western blot analysis indicated that the overexpression of miR-128 significantly downregulated IRS1 expression and its downstream Akt signaling in CRC cells; Moreover miR-128 was negatively associated with IRS1 in CRC tissues compared to adjacent non-tumor tissues; Taken together these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1 metastasis colorectal cancer hsa-miR-142-5p IRS1 1.17581605694506 0.0018174701991234 -0.851786005843366 0.00822245753156005 MirTarget;PITA -0.162709282504736 7.4737363899194e-05 NA NA NA hsa-miR-148a-3p IRS1 1.26728238710376 2.52325607402829e-06 -0.851786005843366 0.00822245753156005 miRNAWalker2_validate;miRTarBase -0.13458990463138 0.0196263890531715 NA NA NA hsa-miR-17-3p IRS1 2.2704817679209 1.1667437320211e-22 -0.851786005843366 0.00822245753156005 MirTarget -0.354313462939604 2.30026319997462e-08 NA NA NA hsa-miR-30c-5p IRS1 0.778774633108 0.000285599212429136 -0.851786005843366 0.00822245753156005 MirTarget;miRNATAP -0.148107410430711 0.042875745264385 NA NA NA hsa-miR-30e-5p IRS1 1.23904909539663 1.35561917122157e-09 -0.851786005843366 0.00822245753156005 MirTarget -0.221461929314315 0.00340873662378119 NA NA NA hsa-miR-338-3p IRS1 0.453166438193782 0.144583389707558 -0.851786005843366 0.00822245753156005 miRanda -0.262034676084363 1.45781485432948e-07 NA NA NA hsa-miR-338-5p IRS1 -0.577691606146419 0.0472212680542825 -0.851786005843366 0.00822245753156005 PITA;miRNATAP -0.182539116228051 0.000747817233267703 NA NA NA hsa-miR-33a-5p IRS1 3.79671563098419 1.15966309820345e-18 -0.851786005843366 0.00822245753156005 MirTarget -0.105113689881829 0.00547712974900804 NA NA NA hsa-miR-421 IRS1 1.17791565395543 6.78526676976629e-06 -0.851786005843366 0.00822245753156005 PITA;miRanda;miRNATAP -0.190666940627758 0.00133004715088958 NA NA NA hsa-miR-590-3p IRS1 2.59289455139753 1.03200520972022e-21 -0.851786005843366 0.00822245753156005 PITA;miRanda;miRNATAP -0.2289962787096 4.65539357390253e-05 NA NA NA hsa-miR-628-5p IRS1 0.799263053510813 2.28892357418044e-05 -0.851786005843366 0.00822245753156005 miRNATAP -0.356362188817271 1.62298962554325e-05 NA NA NA hsa-miR-660-5p IRS1 1.82692095272076 1.92040083607196e-13 -0.851786005843366 0.00822245753156005 MirTarget;miRNATAP -0.446607750875128 7.07986693383541e-14 NA NA NA hsa-miR-7-5p IRS1 2.28980165299999 1.5131097560452e-07 -0.851786005843366 0.00822245753156005 miRNAWalker2_validate;miRTarBase;MirTarget -0.125138886548685 0.000981839028960246 NA NA NA hsa-miR-96-5p IRS1 4.89433085814374 1.92000659886961e-31 -0.851786005843366 0.00822245753156005 MirTarget;TargetScan;miRNATAP -0.104968605701419 0.00302987014600172 21993544 hsa miR 96 up regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas; Altogether these results suggest that hsa-miR-96 may affect the growth of bladder cancer cells by up-regulating IRS1 and MAP4K1 levels functioning as a promising diagnostic marker in human bladder urothelial carcinomas bladder cancer hsa-let-7a-5p IRS2 0.618599506841644 2.76973453058748e-05 -0.911324412136108 0.0110242467169193 MirTarget;TargetScan;miRNATAP -0.276467080944008 0.0208674564943345 NA NA NA hsa-let-7b-5p IRS2 0.604314269683977 0.00140009936153214 -0.911324412136108 0.0110242467169193 miRNAWalker2_validate;MirTarget;miRNATAP -0.20418148746536 0.0277582339958664 NA NA NA hsa-let-7d-5p IRS2 1.33236798905207 1.1741085658466e-13 -0.911324412136108 0.0110242467169193 MirTarget;miRNATAP -0.267954582884597 0.0048642964151477 NA NA NA hsa-let-7e-5p IRS2 0.860104282510173 6.04758298373779e-05 -0.911324412136108 0.0110242467169193 miRNAWalker2_validate;MirTarget;miRNATAP -0.227842993881591 0.0049679520795827 NA NA NA hsa-let-7g-3p IRS2 3.26398061402445 3.96263126107645e-25 -0.911324412136108 0.0110242467169193 MirTarget;miRNATAP -0.246526902349398 3.29473554035218e-06 NA NA NA hsa-let-7g-5p IRS2 1.20061455355116 1.50237505511483e-12 -0.911324412136108 0.0110242467169193 MirTarget;miRNATAP -0.447929367146111 8.29529721044038e-06 NA NA NA hsa-miR-126-5p IRS2 0.895338176458417 2.33372756450713e-05 -0.911324412136108 0.0110242467169193 MirTarget;mirMAP -0.217394958134511 0.00814620693396456 NA NA NA hsa-miR-141-3p IRS2 5.02396127982626 2.19224509139725e-24 -0.911324412136108 0.0110242467169193 MirTarget;TargetScan;miRNATAP -0.156621642072101 1.95203993217853e-06 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2 metastasis thyroid cancer hsa-miR-181a-5p IRS2 2.29556023480783 1.8138457900616e-21 -0.911324412136108 0.0110242467169193 MirTarget;miRNATAP -0.181797649504652 0.00831180696679357 NA NA NA hsa-miR-181b-5p IRS2 2.49307679431293 3.92829250217627e-20 -0.911324412136108 0.0110242467169193 MirTarget;miRNATAP -0.189411387861399 0.00198851872716569 NA NA NA hsa-miR-200a-3p IRS2 4.59434485520731 6.38952518573476e-18 -0.911324412136108 0.0110242467169193 MirTarget;miRNATAP -0.154165919294595 6.20338627675802e-07 NA NA NA hsa-miR-23a-3p IRS2 1.00493340843378 2.55313889288924e-08 -0.911324412136108 0.0110242467169193 mirMAP -0.229481510693266 0.0170321710276926 NA NA NA hsa-miR-30c-5p IRS2 0.778774633108 0.000285599212429136 -0.911324412136108 0.0110242467169193 mirMAP;miRNATAP -0.221928034000617 0.00626524713098078 NA NA NA hsa-miR-30e-5p IRS2 1.23904909539663 1.35561917122157e-09 -0.911324412136108 0.0110242467169193 mirMAP -0.242563199051467 0.00393554960278306 NA NA NA hsa-miR-32-3p IRS2 2.02436999565685 5.94091197945307e-09 -0.911324412136108 0.0110242467169193 mirMAP -0.182091196399327 0.00113466260637848 NA NA NA hsa-miR-32-5p IRS2 2.34056473219422 6.24134585974322e-20 -0.911324412136108 0.0110242467169193 miRNATAP -0.140139849401269 0.031551731331533 NA NA NA hsa-miR-33a-5p IRS2 3.79671563098419 1.15966309820345e-18 -0.911324412136108 0.0110242467169193 miRNAWalker2_validate;MirTarget;miRNATAP -0.130671875646044 0.00188255629407643 NA NA NA hsa-miR-3607-3p IRS2 2.68532138541128 5.66716351955047e-14 -0.911324412136108 0.0110242467169193 MirTarget;miRNATAP -0.183146686125315 0.000148334899683861 NA NA NA hsa-miR-361-5p IRS2 0.971859117235239 5.30236555707088e-09 -0.911324412136108 0.0110242467169193 PITA;mirMAP -0.384416505735187 0.000215139251207925 NA NA NA hsa-miR-429 IRS2 4.48815175680773 2.44117492218206e-17 -0.911324412136108 0.0110242467169193 PITA;miRanda;miRNATAP -0.151908138248959 1.08610489588752e-06 NA NA NA hsa-miR-450b-5p IRS2 1.69244418548325 1.68064054148881e-10 -0.911324412136108 0.0110242467169193 MirTarget;PITA;mirMAP;miRNATAP -0.204028553947135 0.00151688942260199 NA NA NA hsa-miR-452-5p IRS2 1.37180058737183 0.00171494843537772 -0.911324412136108 0.0110242467169193 miRNATAP -0.107216158083119 0.00667736318880342 NA NA NA hsa-miR-484 IRS2 1.81844463411787 1.82951571230938e-15 -0.911324412136108 0.0110242467169193 miRNAWalker2_validate -0.283040383204278 0.000119444416442488 NA NA NA hsa-miR-532-5p IRS2 1.55697650978597 1.57884735535196e-11 -0.911324412136108 0.0110242467169193 MirTarget;PITA;miRNATAP -0.170888661279538 0.020903202948651 NA NA NA hsa-miR-582-5p IRS2 0.609226359812689 0.032988717891497 -0.911324412136108 0.0110242467169193 PITA -0.21631483078051 0.000371669740059196 NA NA NA hsa-miR-589-3p IRS2 2.51971841868825 2.39125940264107e-11 -0.911324412136108 0.0110242467169193 MirTarget -0.174769926314001 0.000630034220100746 NA NA NA hsa-miR-590-3p IRS2 2.59289455139753 1.03200520972022e-21 -0.911324412136108 0.0110242467169193 miRanda -0.183215819439194 0.00355061413601115 NA NA NA hsa-miR-7-5p IRS2 2.28980165299999 1.5131097560452e-07 -0.911324412136108 0.0110242467169193 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.102768558232171 0.0152510493360715 23206698 Thus miR-7-5p may represent a novel tumor suppressor miRNA in melanoma acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling melanoma hsa-miR-877-5p IRS2 2.94916202082736 1.8151927276044e-13 -0.911324412136108 0.0110242467169193 MirTarget -0.228927872221124 1.14579662728382e-06 NA NA NA hsa-miR-944 IRS2 2.91186649218281 1.31574753528144e-06 -0.911324412136108 0.0110242467169193 MirTarget;PITA;mirMAP -0.203546196526736 1.28488459798387e-12 NA NA NA hsa-miR-98-5p IRS2 1.11154309866014 1.24143909012085e-08 -0.911324412136108 0.0110242467169193 miRNAWalker2_validate;MirTarget -0.367949455337867 2.88140233254049e-05 NA NA NA hsa-miR-101-3p KDM5A 0.522819989585461 0.00375627731618038 -0.167658907822398 0.165362666288002 miRNATAP -0.104709256040363 0.00127924751456389 NA NA NA hsa-miR-15a-5p KDR 2.34669284378787 1.69544424500258e-23 -0.809645188569233 0.00140156336172476 miRNATAP -0.127736253549545 0.0104134262261477 NA NA NA hsa-miR-15b-5p KDR 1.57112623124278 9.14247846750597e-13 -0.809645188569233 0.00140156336172476 miRNATAP -0.155621687078152 0.0045182683141369 NA NA NA hsa-miR-16-5p KDR 1.75824877145857 1.68592440033108e-16 -0.809645188569233 0.00140156336172476 miRTarBase;miRNATAP -0.182939670656605 0.00106812366151133 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 2.57951428759379 4.31576118703427e-20 -0.809645188569233 0.00140156336172476 miRNAWalker2_validate -0.229520229616341 6.75997699685035e-08 NA NA NA hsa-miR-200c-3p KDR 3.50132673580082 2.42716349086937e-15 -0.809645188569233 0.00140156336172476 miRNATAP -0.100553706909197 0.000169957263481419 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-23a-3p KDR 1.00493340843378 2.55313889288924e-08 -0.809645188569233 0.00140156336172476 mirMAP -0.286683208573693 2.23043040222106e-05 NA NA NA hsa-miR-3065-3p KDR 2.16221780121195 9.65525739884541e-09 -0.809645188569233 0.00140156336172476 miRNATAP -0.115781865974172 0.00029357167187714 NA NA NA hsa-miR-455-5p KDR 2.2582442061694 1.43472128037398e-13 -0.809645188569233 0.00140156336172476 PITA;miRanda;miRNATAP -0.148297955432885 0.000143983958437006 NA NA NA hsa-miR-590-3p KDR 2.59289455139753 1.03200520972022e-21 -0.809645188569233 0.00140156336172476 miRanda -0.18919157083552 1.89718911518431e-05 NA NA NA hsa-miR-590-5p KDR 3.18300989862077 2.06813568597893e-26 -0.809645188569233 0.00140156336172476 miRanda -0.161280644562926 4.49661990812652e-05 NA NA NA hsa-miR-103a-3p KLF4 1.44083190496858 1.53799939616416e-13 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase -0.370440513388653 5.99842226998452e-06 NA NA NA hsa-miR-107 KLF4 1.30977326593435 1.30372468603965e-11 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase;miRanda;miRNATAP -0.258872045913521 0.00193400491856211 NA NA NA hsa-miR-10a-5p KLF4 1.15016989191194 0.00372037233992369 -2.66899133268835 3.11667300306613e-16 miRNATAP -0.153433622446995 0.000186658583261472 NA NA NA hsa-miR-125a-3p KLF4 1.24490295132072 5.26925231010328e-06 -2.66899133268835 3.11667300306613e-16 miRanda -0.135001285103939 0.0238699233032335 NA NA NA hsa-miR-128-3p KLF4 1.63756041666078 6.79626586407187e-14 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;MirTarget -0.354802185924886 1.03212168144704e-06 NA NA NA hsa-miR-130a-3p KLF4 2.02021855058359 1.26427102520415e-11 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase -0.150226355998753 0.00519061525415889 NA NA NA hsa-miR-148a-3p KLF4 1.26728238710376 2.52325607402829e-06 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.148363314983734 0.0142340236941461 NA NA NA hsa-miR-148b-3p KLF4 1.97815018171325 6.07715327281595e-26 -2.66899133268835 3.11667300306613e-16 MirTarget -0.433307131370933 1.27361464757956e-07 NA NA NA hsa-miR-200b-3p KLF4 3.78235093249346 3.18343003239465e-14 -2.66899133268835 3.11667300306613e-16 MirTarget;TargetScan -0.126887525452082 6.17560775012654e-05 NA NA NA hsa-miR-200c-3p KLF4 3.50132673580082 2.42716349086937e-15 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.109582875233884 0.00217318206296219 NA NA NA hsa-miR-25-3p KLF4 1.36472605225697 4.83790725935681e-11 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.307848289222304 7.18251890931467e-05 NA NA NA hsa-miR-26b-3p KLF4 2.18464160365372 2.11543189388328e-18 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.204489618449199 0.00120572157902676 NA NA NA hsa-miR-26b-5p KLF4 0.885393662798425 3.2116297961629e-06 -2.66899133268835 3.11667300306613e-16 miRNATAP -0.177133895550537 0.040680754227952 NA NA NA hsa-miR-29b-3p KLF4 1.65828197923813 1.02676780888141e-09 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.170216082745274 0.0041544278749748 22751119 Progestin suppression of miR 29 potentiates dedifferentiation of breast cancer cells via KLF4; We demonstrate that miR-29 directly targets Krüppel-like factor 4 KLF4 a transcription factor required for the reprogramming of differentiated cells to pluripotent stem cells and for the maintenance of breast cancer stem cells; These results reveal a novel mechanism whereby progestins increase the stem cell-like population in hormone-responsive breast cancers by decreasing miR-29 to augment PR-mediated upregulation of KLF4 differentiation breast cancer hsa-miR-29c-3p KLF4 -0.00968972577705429 0.97099586346872 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.123468779382537 0.0465958850892821 NA NA NA hsa-miR-301a-3p KLF4 2.81024345929638 2.29784847962242e-17 -2.66899133268835 3.11667300306613e-16 miRNATAP -0.263037610674851 1.23173778446684e-07 NA NA NA hsa-miR-30b-5p KLF4 0.800822374912712 0.000133601914525413 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate -0.162592608125637 0.0385357233744265 NA NA NA hsa-miR-32-5p KLF4 2.34056473219422 6.24134585974322e-20 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.221846917588402 0.000289493277504751 26471298 We also identified Kruppel-like factor 4 KLF4 as a direct target of miR-32; We conclude that miR-32 promotes GC cell proliferation migration and invasion by targeting KLF4 suggesting that the miR-32-KLF4 pathway may be useful in clinical diagnosis and therapeutics gastric cancer hsa-miR-335-5p KLF4 1.77247705492746 2.22457658872091e-06 -2.66899133268835 3.11667300306613e-16 miRNAWalker2_validate -0.125887930833515 0.00362252019576762 NA NA NA hsa-miR-34a-5p KLF4 1.9016323452565 1.43092834643601e-14 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.147421843483855 0.0225947171913702 NA NA NA hsa-miR-363-3p KLF4 1.50575300026701 0.00020976164678918 -2.66899133268835 3.11667300306613e-16 MirTarget -0.138737910095357 0.000531141004282283 NA NA NA hsa-miR-429 KLF4 4.48815175680773 2.44117492218206e-17 -2.66899133268835 3.11667300306613e-16 MirTarget;PITA;miRanda;miRNATAP -0.138617433153382 2.48477140811368e-06 NA NA NA hsa-miR-590-3p KLF4 2.59289455139753 1.03200520972022e-21 -2.66899133268835 3.11667300306613e-16 miRanda -0.229829794295701 0.000100090061909003 NA NA NA hsa-miR-92a-3p KLF4 2.06460102658973 1.44784291084757e-19 -2.66899133268835 3.11667300306613e-16 MirTarget;miRNATAP -0.274984370774326 6.40957426854041e-05 27131314 Additionally KLF4 was identified as a direct target of miR-92a in CRC cells through bioinformatics and luciferase reporter analysis; KLF4 overexpression attenuated the effects of miR-92a on the regulation of CRC cell motility; In conclusion our data demonstrated that miR-92a may play a positive role in the colorectal carcinogenesis by promoting the proliferation and migration of CRC cells through targeting KLF4 as well as downstream p21 motility;tumorigenesis colorectal cancer hsa-miR-103a-2-5p LATS1 2.47599305985086 7.933028987326e-11 -0.728264634976516 0.00251777297344159 MirTarget -0.159677435803582 2.15934704656081e-06 NA NA NA hsa-miR-103a-3p LATS1 1.44083190496858 1.53799939616416e-13 -0.728264634976516 0.00251777297344159 miRNAWalker2_validate;MirTarget -0.152438604727689 0.00955458257840729 NA NA NA hsa-miR-10b-5p LATS1 -0.155951595811628 0.555006386998027 -0.728264634976516 0.00251777297344159 MirTarget -0.11302716727672 0.0111798866324956 NA NA NA hsa-miR-126-5p LATS1 0.895338176458417 2.33372756450713e-05 -0.728264634976516 0.00251777297344159 mirMAP -0.135126983640661 0.0145735923160006 NA NA NA hsa-miR-15a-5p LATS1 2.34669284378787 1.69544424500258e-23 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.21605844363242 4.24104083225893e-06 NA NA NA hsa-miR-16-2-3p LATS1 2.31623086727196 4.29838149388188e-20 -0.728264634976516 0.00251777297344159 mirMAP -0.120088794836129 0.0068794745810913 NA NA NA hsa-miR-181a-2-3p LATS1 2.19062681262366 3.81790102612782e-13 -0.728264634976516 0.00251777297344159 MirTarget -0.1296837139578 0.000571196798970507 NA NA NA hsa-miR-181a-5p LATS1 2.29556023480783 1.8138457900616e-21 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.226306793227026 8.10370433992916e-07 NA NA NA hsa-miR-181b-5p LATS1 2.49307679431293 3.92829250217627e-20 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.154197113166953 0.000176184316961279 NA NA NA hsa-miR-181c-5p LATS1 1.58587920618301 1.57506918816933e-10 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.203158260792258 1.0310591721741e-05 NA NA NA hsa-miR-181d-5p LATS1 1.52204912185579 9.2693319057748e-08 -0.728264634976516 0.00251777297344159 MirTarget -0.125240269304981 0.00200915481257029 NA NA NA hsa-miR-193a-3p LATS1 1.60460546928078 2.86169793322984e-07 -0.728264634976516 0.00251777297344159 miRanda -0.112546115005862 0.00230328369177318 NA NA NA hsa-miR-194-5p LATS1 1.8992998339217 3.76507853301977e-10 -0.728264634976516 0.00251777297344159 miRNATAP -0.108848605291542 0.00400268569989429 NA NA NA hsa-miR-19b-1-5p LATS1 2.57951428759379 4.31576118703427e-20 -0.728264634976516 0.00251777297344159 MirTarget -0.118570305678162 0.00374857968966866 NA NA NA hsa-miR-21-5p LATS1 2.73773305747971 1.38864982139576e-43 -0.728264634976516 0.00251777297344159 miRNAWalker2_validate -0.238133309919206 7.69461047041298e-06 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-25-3p LATS1 1.36472605225697 4.83790725935681e-11 -0.728264634976516 0.00251777297344159 miRNATAP -0.162133138584792 0.00349580943726463 NA NA NA hsa-miR-29a-5p LATS1 1.46749674755271 3.34605004270294e-07 -0.728264634976516 0.00251777297344159 MirTarget -0.174592660081215 3.71221984627273e-05 NA NA NA hsa-miR-30d-3p LATS1 0.977747550180601 4.3048212205381e-05 -0.728264634976516 0.00251777297344159 mirMAP -0.160221744545766 0.00102477436386411 NA NA NA hsa-miR-32-5p LATS1 2.34056473219422 6.24134585974322e-20 -0.728264634976516 0.00251777297344159 miRNATAP -0.14631410994458 0.000810340119615875 NA NA NA hsa-miR-320a LATS1 0.438165828017084 0.0390159073347133 -0.728264634976516 0.00251777297344159 miRanda;miRNATAP -0.153029850507115 0.00586562412569888 NA NA NA hsa-miR-3607-3p LATS1 2.68532138541128 5.66716351955047e-14 -0.728264634976516 0.00251777297344159 MirTarget -0.115506872781635 0.000381831927749546 NA NA NA hsa-miR-497-5p LATS1 0.0257087130056286 0.918145413833358 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.155622272383027 0.000925173910257878 NA NA NA hsa-miR-532-3p LATS1 1.96631878320218 4.53421954361695e-13 -0.728264634976516 0.00251777297344159 MirTarget;miRNATAP -0.100816512957293 0.0164414190873389 NA NA NA hsa-miR-590-3p LATS1 2.59289455139753 1.03200520972022e-21 -0.728264634976516 0.00251777297344159 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.120951700888804 0.0042362669164196 NA NA NA hsa-miR-590-5p LATS1 3.18300989862077 2.06813568597893e-26 -0.728264634976516 0.00251777297344159 miRanda;miRNATAP -0.148269587763011 7.98398714476422e-05 NA NA NA hsa-miR-92a-3p LATS1 2.06460102658973 1.44784291084757e-19 -0.728264634976516 0.00251777297344159 miRNATAP -0.105030582188018 0.0334152425488449 NA NA NA hsa-miR-103a-3p LATS2 1.44083190496858 1.53799939616416e-13 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.545078088921721 1.01249305570253e-24 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-107 LATS2 1.30977326593435 1.30372468603965e-11 -1.50195936145544 2.88260453000506e-11 PITA;miRanda;miRNATAP -0.416521294602422 5.32722251910862e-14 NA NA NA hsa-miR-125a-5p LATS2 0.599529391575274 0.0102300147180307 -1.50195936145544 2.88260453000506e-11 miRanda -0.21781018086606 5.01985416818712e-06 NA NA NA hsa-miR-130b-5p LATS2 2.9963110846538 1.98883029416455e-18 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.302045570964604 4.77360340232615e-23 NA NA NA hsa-miR-15a-5p LATS2 2.34669284378787 1.69544424500258e-23 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.374491797147539 7.9868614793595e-18 NA NA NA hsa-miR-15b-5p LATS2 1.57112623124278 9.14247846750597e-13 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.433674019729412 9.15682310083165e-20 NA NA NA hsa-miR-16-5p LATS2 1.75824877145857 1.68592440033108e-16 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.386303125464207 4.6978239258313e-15 NA NA NA hsa-miR-188-5p LATS2 2.52825126596644 6.78099435999778e-14 -1.50195936145544 2.88260453000506e-11 PITA -0.160210846022289 2.42310582682938e-06 NA NA NA hsa-miR-200b-3p LATS2 3.78235093249346 3.18343003239465e-14 -1.50195936145544 2.88260453000506e-11 TargetScan -0.239804941398232 6.61387628314149e-33 NA NA NA hsa-miR-200c-3p LATS2 3.50132673580082 2.42716349086937e-15 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.25601848144934 2.48894504027114e-29 NA NA NA hsa-miR-25-3p LATS2 1.36472605225697 4.83790725935681e-11 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.454631951504411 4.26702489689902e-19 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-30c-5p LATS2 0.778774633108 0.000285599212429136 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.406395457209951 8.42251456625388e-16 NA NA NA hsa-miR-30d-5p LATS2 0.675423997639582 0.00270618816039773 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.39436956563667 2.52948655768174e-16 NA NA NA hsa-miR-32-3p LATS2 2.02436999565685 5.94091197945307e-09 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.252828079392184 6.10666994340033e-13 NA NA NA hsa-miR-32-5p LATS2 2.34056473219422 6.24134585974322e-20 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.328851943356694 4.23747028480072e-16 NA NA NA hsa-miR-33a-3p LATS2 1.72765312072219 1.51784443453521e-07 -1.50195936145544 2.88260453000506e-11 mirMAP -0.263137980113084 2.27886870181046e-13 NA NA NA hsa-miR-342-3p LATS2 1.49115144672245 1.43879249744621e-07 -1.50195936145544 2.88260453000506e-11 PITA;miRanda -0.128936577647804 0.00092028917287548 NA NA NA hsa-miR-361-5p LATS2 0.971859117235239 5.30236555707088e-09 -1.50195936145544 2.88260453000506e-11 miRanda -0.602049312013823 4.88606279740226e-21 NA NA NA hsa-miR-362-3p LATS2 2.0756816987665 3.89026064579331e-12 -1.50195936145544 2.88260453000506e-11 PITA;miRanda -0.167202266945711 8.02098864297333e-06 NA NA NA hsa-miR-374a-5p LATS2 0.484615721953736 0.0042981729815149 -1.50195936145544 2.88260453000506e-11 mirMAP -0.274599596911397 3.52932415706869e-05 NA NA NA hsa-miR-429 LATS2 4.48815175680773 2.44117492218206e-17 -1.50195936145544 2.88260453000506e-11 PITA;miRanda;miRNATAP -0.223274644955359 8.82062181506915e-33 NA NA NA hsa-miR-590-3p LATS2 2.59289455139753 1.03200520972022e-21 -1.50195936145544 2.88260453000506e-11 PITA;miRanda -0.304394683115022 8.31248193031269e-15 NA NA NA hsa-miR-92a-3p LATS2 2.06460102658973 1.44784291084757e-19 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.46068812600106 3.77311823852666e-25 NA NA NA hsa-miR-93-5p LATS2 3.03961860136032 1.11672209617395e-24 -1.50195936145544 2.88260453000506e-11 miRNAWalker2_validate -0.422183319683058 1.37660464449381e-38 NA NA NA hsa-miR-96-5p LATS2 4.89433085814374 1.92000659886961e-31 -1.50195936145544 2.88260453000506e-11 miRNATAP -0.269868454196079 2.91863438557395e-30 NA NA NA hsa-let-7g-3p LMO1 3.26398061402445 3.96263126107645e-25 -2.22094296560193 1.63498700699519e-05 MirTarget;miRNATAP -0.526509407396761 3.20018370719939e-12 NA NA NA hsa-miR-148a-5p LMO1 1.16173838132242 0.000148929299881612 -2.22094296560193 1.63498700699519e-05 MirTarget -0.227746678290869 0.00535780711823695 NA NA NA hsa-miR-181a-5p LMO1 2.29556023480783 1.8138457900616e-21 -2.22094296560193 1.63498700699519e-05 MirTarget;miRNATAP -0.460758999499945 3.17748557441274e-06 NA NA NA hsa-miR-181b-5p LMO1 2.49307679431293 3.92829250217627e-20 -2.22094296560193 1.63498700699519e-05 MirTarget;miRNATAP -0.394337083665148 7.73613517058049e-06 NA NA NA hsa-miR-181c-5p LMO1 1.58587920618301 1.57506918816933e-10 -2.22094296560193 1.63498700699519e-05 MirTarget;miRNATAP -0.433212000500094 1.24976598239235e-05 NA NA NA hsa-miR-181d-5p LMO1 1.52204912185579 9.2693319057748e-08 -2.22094296560193 1.63498700699519e-05 MirTarget -0.310966693238286 0.00035683591939514 NA NA NA hsa-miR-101-3p MAP2K1 0.522819989585461 0.00375627731618038 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.179174585612232 2.32589570104786e-07 NA NA NA hsa-miR-30c-5p MAP2K1 0.778774633108 0.000285599212429136 0.329146605656592 0.0110879553061078 miRNAWalker2_validate -0.1435696131991 6.86626187272449e-07 NA NA NA hsa-miR-125a-5p MAP3K1 0.599529391575274 0.0102300147180307 0.427069954621904 0.0352041986280003 miRNAWalker2_validate -0.126195148873375 0.00275477598947122 NA NA NA hsa-miR-125b-5p MAP3K13 -1.16462950151259 0.000288900271798384 0.0789266280328784 0.789464978516727 miRNATAP -0.122469019003326 0.00561332960537856 NA NA NA hsa-miR-127-5p MAP3K13 1.19850695520181 4.10976607177645e-05 0.0789266280328784 0.789464978516727 mirMAP -0.122883639757483 0.0114625194433591 NA NA NA hsa-miR-1271-5p MAP3K13 0.970418832993172 0.000609742584380688 0.0789266280328784 0.789464978516727 mirMAP -0.133482053224248 0.0081378639238516 NA NA NA hsa-miR-139-5p MAP3K13 -1.52606598644743 1.20474151350665e-08 0.0789266280328784 0.789464978516727 miRanda -0.137909637651281 0.00876039575222123 NA NA NA hsa-miR-22-5p MAP3K13 1.88011544159252 1.63978222572222e-16 0.0789266280328784 0.789464978516727 mirMAP -0.136953305875861 0.0242183343153108 NA NA NA hsa-miR-369-3p MAP3K13 0.946781510019564 0.00134850306966842 0.0789266280328784 0.789464978516727 mirMAP;miRNATAP -0.104444365628799 0.0310539721229252 NA NA NA hsa-miR-374a-3p MAP3K13 0.533309330504947 0.00192918429705142 0.0789266280328784 0.789464978516727 mirMAP -0.287204848309896 0.000608084670797659 NA NA NA hsa-miR-376c-3p MAP3K13 -0.0429546438511621 0.900736192374863 0.0789266280328784 0.789464978516727 mirMAP -0.100410743206295 0.015888055140979 NA NA NA hsa-miR-409-3p MAP3K13 0.877551657794358 0.00171210686733898 0.0789266280328784 0.789464978516727 mirMAP -0.104125415013763 0.0414541125203843 NA NA NA hsa-miR-432-5p MAP3K13 -0.128200716359323 0.676832757701632 0.0789266280328784 0.789464978516727 MirTarget -0.114639487070715 0.0145176052918669 NA NA NA hsa-miR-539-5p MAP3K13 0.95216780650456 0.00284373332122135 0.0789266280328784 0.789464978516727 mirMAP -0.132037334925622 0.00326664521674991 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-miR-28-5p MAX 0.230152919654905 0.0742909586754846 -0.300810607733172 0.00220412918683644 miRanda -0.121010016036467 0.00138402325810049 NA NA NA hsa-let-7g-3p MCL1 3.26398061402445 3.96263126107645e-25 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.115810411362269 3.39117883522902e-06 NA NA NA hsa-miR-101-3p MCL1 0.522819989585461 0.00375627731618038 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate;miRTarBase -0.154167833785504 0.00074378867351686 21993632;19155302;26036638 MiR 101 and Mcl 1 in non small cell lung cancer: expression profile and clinical significance; The aim of this study was to investigate the expression profile of miR-101 and its target gene Mcl-1 in NSCLC and to assess their clinical significance; QRT-PCR was used in the detection of miR-101 and Mcl-1 mRNA expression both in NSCLC tissue and in adjacent normal lung tissue; Down-regulation of miR-101 was associated with overexpression of Mcl-1 mRNA in NSCLC tissue when compared with corresponding normal tissue with a negative correlation r = -0.724 P < 0.01; A comparison of survival curves of low versus high expressers of miR-101 and Mcl-1 revealed a highly significant difference in NSCLC P < 0.05 which suggests that reduced expression of miR-101 versus overexpression of Mcl-1 is associated with a poorer prognosis; Our results suggest that down-regulation of miR-101 may result in enhanced expression of Mcl-1 in NSCLC which consequently favored tumor progression; MiR-101 and Mcl-1 may play important roles as biomarkers for prognosis and therapeutic targets in NSCLC;Moreover silencing of Mcl-1 phenocopied the effect of miR-101 and forced expression of Mcl-1 could reverse the proapoptotic effect of miR-101; These results indicate that miR-101 may exert its proapoptotic function via targeting Mcl-1;The aim of our study was to investigate the functional role of both miR-101 and MCL-1 in the sensitivity of human triple-negative breast cancer TNBC to paclitaxel; Luciferase assay results confirmed MCL-1 as a direct target gene of miR-101; MiR-101 inhibited MCL-1 expression in TNBC cells and transplanted tumors; There was a negative correlation between the level of expression of miR-101 and MCL-1 in TNBC tissues; Furthermore miR-101 increased paclitaxel sensitivity by inhibiting MCL-1 expression worse prognosis;poor survival;progression;; lung squamous cell cancer;liver cancer;breast cancer hsa-miR-106b-5p MCL1 2.46782146831112 1.36171495805632e-23 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.175969517504363 1.46516427491805e-08 NA NA NA hsa-miR-125a-5p MCL1 0.599529391575274 0.0102300147180307 -0.966384598042312 6.2852193244413e-09 MirTarget;PITA;miRanda -0.179850478189693 2.32572836009865e-07 NA NA NA hsa-miR-148b-5p MCL1 2.18024067300781 2.84770452413262e-14 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.125866449821125 1.53117330549739e-05 NA NA NA hsa-miR-151a-3p MCL1 1.24018761527407 1.08839919675408e-07 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.198519929966059 6.3961593224112e-09 NA NA NA hsa-miR-15a-5p MCL1 2.34669284378787 1.69544424500258e-23 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.107808676234929 0.00110378696128458 NA NA NA hsa-miR-17-5p MCL1 3.2710598467455 9.93128340539455e-27 -0.966384598042312 6.2852193244413e-09 MirTarget;TargetScan;miRNATAP -0.108351617760068 1.42433347252796e-05 NA NA NA hsa-miR-186-5p MCL1 1.47445398888668 3.0781726595413e-15 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate;mirMAP -0.133392046569594 0.00178902572097603 NA NA NA hsa-miR-20a-5p MCL1 3.15577933619191 4.19753346442454e-25 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.113265036863355 6.45027870943099e-06 23594563 Subsequent investigations revealed that miR-20a directly targeted myeloid cell leukemia sequence 1 Mcl-1 and reduced the endogenous protein level of Mcl-1 in HCC cells liver cancer hsa-miR-30d-5p MCL1 0.675423997639582 0.00270618816039773 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate -0.196335685987109 4.80731179408169e-08 NA NA NA hsa-miR-320a MCL1 0.438165828017084 0.0390159073347133 -0.966384598042312 6.2852193244413e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.153148453172002 7.38962353071285e-05 26753959 Down regulation of miR 320 associated with cancer progression and cell apoptosis via targeting Mcl 1 in cervical cancer; MiR-320 has been reported to be down-regulated in various types of cancer and bioinformatics prediction indicated that it may regulate the expression of Mcl-1; The aim of this study is to investigate the role of miR-320 and its target gene Mcl-1 in cervical cancer progression and to assess their clinical significance; miR-320 and Mcl-1 expressions in human cervical cancer tissues were investigated by qRT-PCR in situ hybridization and immunohistochemical staining respectively; MiR-320 expression is significantly down-regulated versus Mcl-1 expression is up-regulated in cervical cancer tissues compared with normal controls with a negative correlation between them; Luciferase assay showed that miR-320 negatively regulates Mcl-1 expression; In addition miR-320 induces apoptosis via down-regulation of Mcl-1 and activation of caspase-3 but inhibits cell proliferation migration invasion and tumorigenesis in cervical cancer cells; Our studies show that miR-320 expression is decreased in cervical cancer and its expression is negatively correlated with Mcl-1 expression in cervical cancer; In addition miR-320 inhibits cervical cancer progression by down-regulation of Mcl-1 progression;tumorigenesis cervical and endocervical cancer hsa-miR-335-3p MCL1 3.08791651139852 5.31309869723517e-12 -0.966384598042312 6.2852193244413e-09 mirMAP -0.104489944006683 2.24625518502697e-09 NA NA NA hsa-miR-361-5p MCL1 0.971859117235239 5.30236555707088e-09 -0.966384598042312 6.2852193244413e-09 miRanda -0.254409362204897 1.52555889152521e-07 NA NA NA hsa-miR-93-5p MCL1 3.03961860136032 1.11672209617395e-24 -0.966384598042312 6.2852193244413e-09 MirTarget;miRNATAP -0.182893495021059 5.94058378435324e-13 NA NA NA hsa-miR-940 MCL1 3.21011374578759 2.7923171128495e-14 -0.966384598042312 6.2852193244413e-09 PITA;miRNATAP -0.133864697880394 2.41178789209135e-11 NA NA NA hsa-miR-125a-5p MDC1 0.599529391575274 0.0102300147180307 0.0984839369817863 0.508759922629015 miRanda -0.105485509044234 0.000614924985179763 NA NA NA hsa-miR-22-3p MDC1 1.21545661147757 1.61670170137775e-13 0.0984839369817863 0.508759922629015 MirTarget -0.145558431845141 0.000689252341364872 NA NA NA hsa-miR-320a MDC1 0.438165828017084 0.0390159073347133 0.0984839369817863 0.508759922629015 miRanda -0.120520173692472 0.000390037980518746 NA NA NA hsa-miR-664a-5p MDC1 0.505019913598436 0.032933350691651 0.0984839369817863 0.508759922629015 MirTarget -0.173722464054409 8.09538328647884e-09 NA NA NA hsa-let-7i-5p MDM4 0.412877696970403 0.00622731051981756 -0.0417166726103293 0.796356265058254 MirTarget -0.310234734345432 2.01306684248206e-09 NA NA NA hsa-miR-152-3p MDM4 -0.0480232621705712 0.844347735441565 -0.0417166726103293 0.796356265058254 MirTarget -0.198828633232754 2.62918534012835e-10 NA NA NA hsa-miR-21-3p MDM4 2.19296355304364 4.63665722759779e-15 -0.0417166726103293 0.796356265058254 MirTarget -0.181325523485394 5.97587010184892e-12 NA NA NA hsa-miR-21-5p MDM4 2.73773305747971 1.38864982139576e-43 -0.0417166726103293 0.796356265058254 miRNAWalker2_validate;mirMAP -0.177477843606092 5.08057823919745e-07 NA NA NA hsa-miR-22-5p MDM4 1.88011544159252 1.63978222572222e-16 -0.0417166726103293 0.796356265058254 MirTarget -0.199217576141233 9.07348970289514e-10 NA NA NA hsa-miR-222-5p MDM4 1.25632771414778 0.000138653440511922 -0.0417166726103293 0.796356265058254 mirMAP -0.135708562618783 4.32610541413678e-09 NA NA NA hsa-miR-27a-3p MDM4 1.66542180327138 4.93775737894805e-13 -0.0417166726103293 0.796356265058254 miRNATAP -0.13635021218626 3.33316430813592e-05 NA NA NA hsa-miR-29a-5p MDM4 1.46749674755271 3.34605004270294e-07 -0.0417166726103293 0.796356265058254 mirMAP -0.124414670397606 9.80377796420373e-06 NA NA NA hsa-miR-340-5p MDM4 0.30282999308409 0.157744789519131 -0.0417166726103293 0.796356265058254 mirMAP -0.100731792116629 0.00600243663457417 NA NA NA hsa-miR-424-5p MDM4 1.61930224569578 1.89642549274994e-10 -0.0417166726103293 0.796356265058254 mirMAP -0.10877766912749 0.000288454619788618 NA NA NA hsa-miR-766-3p MDM4 1.2456012547833 6.44584025471128e-06 -0.0417166726103293 0.796356265058254 MirTarget -0.170466790172467 5.73614835694442e-10 NA NA NA hsa-miR-92b-3p MDM4 1.20409245530001 3.41055816361655e-06 -0.0417166726103293 0.796356265058254 mirMAP -0.131207721486885 9.4896097992838e-06 NA NA NA hsa-miR-100-5p MED12 -1.48442967087177 1.5610956769298e-05 0.119084746419974 0.378279442618952 miRNAWalker2_validate -0.103760902142622 2.0488688322926e-08 NA NA NA hsa-miR-342-3p MED12 1.49115144672245 1.43879249744621e-07 0.119084746419974 0.378279442618952 miRanda -0.106830667733633 2.01060159873897e-06 NA NA NA hsa-let-7a-3p MITF 1.42015538786275 7.03375209382654e-13 -2.11043666647908 2.14681139044162e-09 MirTarget;miRNATAP -0.419252708479998 9.42257656358065e-07 NA NA NA hsa-let-7f-1-3p MITF 1.55054488387679 7.31326775537952e-11 -2.11043666647908 2.14681139044162e-09 MirTarget -0.211378304979637 0.00422079610686225 NA NA NA hsa-miR-101-3p MITF 0.522819989585461 0.00375627731618038 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.317477052125715 0.00109733944789535 23962556 MiR 101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2; We identified microphthalmia-associated transcription factor MITF as a direct target of miR-101; Functional assays showed that miR-101 suppressed invasion and proliferation - an outcome that could be phenocopied by siRNA knockdown of MITF and EZH2 melanoma hsa-miR-107 MITF 1.30977326593435 1.30372468603965e-11 -2.11043666647908 2.14681139044162e-09 miRanda -0.90014275313744 2.69916844600728e-27 NA NA NA hsa-miR-125a-3p MITF 1.24490295132072 5.26925231010328e-06 -2.11043666647908 2.14681139044162e-09 PITA;miRanda -0.243949936383525 0.000107049360007546 NA NA NA hsa-miR-126-5p MITF 0.895338176458417 2.33372756450713e-05 -2.11043666647908 2.14681139044162e-09 MirTarget;mirMAP -0.467481362388946 7.62864079734945e-09 NA NA NA hsa-miR-144-3p MITF 0.658119849508907 0.146943823997989 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.210409447077596 7.04785214233844e-08 NA NA NA hsa-miR-148a-3p MITF 1.26728238710376 2.52325607402829e-06 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.204029893204326 0.00143209590242663 20644734 miR 148 regulates Mitf in melanoma cells; Furthermore miR-148 was shown to affect Mitf mRNA expression in melanoma cells through a conserved binding site in the 3'UTR sequence of mouse and human Mitf; Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells melanoma hsa-miR-16-2-3p MITF 2.31623086727196 4.29838149388188e-20 -2.11043666647908 2.14681139044162e-09 mirMAP -0.61504604627877 1.09640129380088e-22 NA NA NA hsa-miR-182-5p MITF 3.53923166221814 5.07781258121574e-21 -2.11043666647908 2.14681139044162e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.459685004473695 4.82335519155237e-29 19188590 In human tissues expression of miR-182 increases with progression from primary to metastatic melanoma and inversely correlates with FOXO3 and microphthalmia-associated transcription factor levels progression melanoma hsa-miR-186-5p MITF 1.47445398888668 3.0781726595413e-15 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.944996140196949 1.13922357715714e-28 NA NA NA hsa-miR-200c-3p MITF 3.50132673580082 2.42716349086937e-15 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.370919113758088 3.74236352265043e-25 NA NA NA hsa-miR-26a-2-3p MITF 0.823520019989974 0.00017092160823769 -2.11043666647908 2.14681139044162e-09 mirMAP -0.169603051527751 0.0342653328416485 NA NA NA hsa-miR-3065-5p MITF 2.74629919868982 1.86846589298284e-08 -2.11043666647908 2.14681139044162e-09 mirMAP -0.269633332703381 1.45951107369929e-10 NA NA NA hsa-miR-30d-3p MITF 0.977747550180601 4.3048212205381e-05 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.478569467690356 1.67715913965537e-11 NA NA NA hsa-miR-30e-3p MITF -0.215663037684509 0.235375122783546 -2.11043666647908 2.14681139044162e-09 mirMAP -0.432427635532735 7.24252465036351e-06 NA NA NA hsa-miR-32-3p MITF 2.02436999565685 5.94091197945307e-09 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.452578247826932 5.65193969625769e-17 NA NA NA hsa-miR-32-5p MITF 2.34056473219422 6.24134585974322e-20 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.601742551321755 2.38566601773211e-22 NA NA NA hsa-miR-3200-3p MITF 2.70510522077868 1.90469509928484e-08 -2.11043666647908 2.14681139044162e-09 MirTarget -0.355908253826661 2.57323511548454e-23 NA NA NA hsa-miR-320a MITF 0.438165828017084 0.0390159073347133 -2.11043666647908 2.14681139044162e-09 PITA;miRanda -0.424211760282132 2.03581297427954e-07 NA NA NA hsa-miR-320b MITF 1.55692969039548 1.41071034251915e-08 -2.11043666647908 2.14681139044162e-09 PITA;miRanda -0.507269185293414 3.64986264827143e-17 NA NA NA hsa-miR-331-3p MITF 2.28379581858927 1.99663919173155e-18 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.663685321840282 2.08651147902277e-28 NA NA NA hsa-miR-335-3p MITF 3.08791651139852 5.31309869723517e-12 -2.11043666647908 2.14681139044162e-09 mirMAP -0.249879247245221 1.36340631241209e-11 NA NA NA hsa-miR-33a-3p MITF 1.72765312072219 1.51784443453521e-07 -2.11043666647908 2.14681139044162e-09 mirMAP -0.50691027337872 2.28468394242288e-20 NA NA NA hsa-miR-34a-3p MITF 1.75590866103657 8.02801510630657e-09 -2.11043666647908 2.14681139044162e-09 MirTarget -0.438901834940701 5.90896046706837e-13 NA NA NA hsa-miR-375 MITF 1.13910305294079 0.0512283522214186 -2.11043666647908 2.14681139044162e-09 miRanda -0.127048912355923 1.63073750336725e-05 NA NA NA hsa-miR-421 MITF 1.17791565395543 6.78526676976629e-06 -2.11043666647908 2.14681139044162e-09 PITA;miRanda;mirMAP -0.547684544202816 8.03575255667148e-18 NA NA NA hsa-miR-429 MITF 4.48815175680773 2.44117492218206e-17 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.304909034651769 1.14794767199277e-24 NA NA NA hsa-miR-508-3p MITF 1.05493034310846 0.0393857095042515 -2.11043666647908 2.14681139044162e-09 PITA;miRNATAP -0.120590058280043 0.000480077271234284 NA NA NA hsa-miR-542-3p MITF 1.18832665895751 1.98700670691565e-07 -2.11043666647908 2.14681139044162e-09 miRanda -0.229865161647535 0.00232304588086565 NA NA NA hsa-miR-582-5p MITF 0.609226359812689 0.032988717891497 -2.11043666647908 2.14681139044162e-09 MirTarget;PITA;miRNATAP -0.236241488867162 9.96507359441005e-05 NA NA NA hsa-miR-590-3p MITF 2.59289455139753 1.03200520972022e-21 -2.11043666647908 2.14681139044162e-09 mirMAP -0.548373557984915 8.26040158751279e-20 NA NA NA hsa-miR-7-1-3p MITF 1.84950311431067 1.25300363397654e-13 -2.11043666647908 2.14681139044162e-09 mirMAP -0.563747163973148 6.21416401293993e-18 NA NA NA hsa-miR-92a-3p MITF 2.06460102658973 1.44784291084757e-19 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.873196225441739 4.00477315398684e-39 NA NA NA hsa-miR-92b-3p MITF 1.20409245530001 3.41055816361655e-06 -2.11043666647908 2.14681139044162e-09 miRNATAP -0.211657340070872 0.00146759834651592 NA NA NA hsa-miR-944 MITF 2.91186649218281 1.31574753528144e-06 -2.11043666647908 2.14681139044162e-09 PITA;mirMAP -0.214977410858337 5.54696464610878e-14 NA NA NA hsa-miR-96-5p MITF 4.89433085814374 1.92000659886961e-31 -2.11043666647908 2.14681139044162e-09 miRTarBase;TargetScan;miRNATAP -0.446007419875901 1.09201784851785e-34 NA NA NA hsa-miR-98-5p MITF 1.11154309866014 1.24143909012085e-08 -2.11043666647908 2.14681139044162e-09 miRNAWalker2_validate -0.862387323761461 5.9158503516273e-25 NA NA NA hsa-let-7a-5p MPL 0.618599506841644 2.76973453058748e-05 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.416563028979525 5.56794407539324e-08 NA NA NA hsa-let-7d-5p MPL 1.33236798905207 1.1741085658466e-13 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.342093386535112 2.05140547531861e-08 NA NA NA hsa-let-7e-5p MPL 0.860104282510173 6.04758298373779e-05 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.223425928962936 2.01215270315669e-05 NA NA NA hsa-let-7f-5p MPL 0.495648727272215 0.00355972741198794 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.186243696740052 0.00566490142227862 NA NA NA hsa-miR-128-3p MPL 1.63756041666078 6.79626586407187e-14 -1.58407041011234 3.41937402880313e-12 MirTarget -0.318984233465614 1.16832989950246e-10 NA NA NA hsa-miR-151a-5p MPL 2.32422038747303 2.66226949101065e-18 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate;miRTarBase -0.323041522617547 2.45795244536463e-16 NA NA NA hsa-miR-339-5p MPL 2.68710938429893 3.03134080808154e-16 -1.58407041011234 3.41937402880313e-12 miRanda -0.106558009502114 0.00128190799104349 NA NA NA hsa-miR-342-5p MPL 1.74634624752902 3.89286511372155e-11 -1.58407041011234 3.41937402880313e-12 MirTarget -0.249292823854211 1.52083295904757e-09 NA NA NA hsa-miR-455-5p MPL 2.2582442061694 1.43472128037398e-13 -1.58407041011234 3.41937402880313e-12 MirTarget;miRanda -0.195531752672223 3.5754819941582e-08 NA NA NA hsa-miR-542-3p MPL 1.18832665895751 1.98700670691565e-07 -1.58407041011234 3.41937402880313e-12 miRanda -0.117632536484027 0.0166866377557842 NA NA NA hsa-miR-625-5p MPL 1.42540152147292 1.95797147911206e-06 -1.58407041011234 3.41937402880313e-12 MirTarget -0.198090360494282 1.11234629743124e-06 NA NA NA hsa-miR-98-5p MPL 1.11154309866014 1.24143909012085e-08 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.267763166829617 2.66486548695184e-06 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-let-7a-3p MYCN 1.42015538786275 7.03375209382654e-13 1.30601411127991 0.0558603853957529 MirTarget;miRNATAP -0.458689330294769 0.00521634090959966 NA NA NA hsa-let-7b-3p MYCN 0.868207752019623 1.30460056774366e-05 1.30601411127991 0.0558603853957529 MirTarget;miRNATAP -0.50358273052638 0.0024327036616213 NA NA NA hsa-let-7b-5p MYCN 0.604314269683977 0.00140009936153214 1.30601411127991 0.0558603853957529 miRNATAP -0.404955990718604 0.0217776834821497 NA NA NA hsa-miR-29a-3p MYCN -0.35074463683376 0.161238718982428 1.30601411127991 0.0558603853957529 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.5202601577855 8.3614470156538e-05 NA NA NA hsa-miR-338-5p MYCN -0.577691606146419 0.0472212680542825 1.30601411127991 0.0558603853957529 MirTarget;PITA;miRNATAP -0.239367996130735 0.0375037263982204 NA NA NA hsa-miR-34c-5p MYCN 2.07190852984647 7.35776320806257e-08 1.30601411127991 0.0558603853957529 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.325743898886791 0.000297079894651855 NA NA NA hsa-miR-140-5p NCOR1 0.844753502512594 3.73722278438606e-05 -0.697475661075322 7.56012496866254e-05 miRanda -0.204842865617412 7.91676578258419e-07 NA NA NA hsa-miR-1976 NCOR1 2.06550563678192 7.81396978619772e-18 -0.697475661075322 7.56012496866254e-05 miRNATAP -0.124989156968858 0.000272123914841712 NA NA NA hsa-miR-199a-5p NCOR1 0.592984035153911 0.0674836634175293 -0.697475661075322 7.56012496866254e-05 MirTarget;miRNATAP -0.152474727140998 4.79790910447938e-09 NA NA NA hsa-miR-199b-5p NCOR1 0.218704279044827 0.519493319158441 -0.697475661075322 7.56012496866254e-05 MirTarget -0.161332909559795 7.63613608681922e-11 NA NA NA hsa-miR-29a-5p NCOR1 1.46749674755271 3.34605004270294e-07 -0.697475661075322 7.56012496866254e-05 MirTarget -0.12061423383688 0.000102971065999108 NA NA NA hsa-miR-338-3p NCOR1 0.453166438193782 0.144583389707558 -0.697475661075322 7.56012496866254e-05 miRanda -0.138843857359773 3.89793879148974e-07 NA NA NA hsa-miR-590-5p NCOR1 3.18300989862077 2.06813568597893e-26 -0.697475661075322 7.56012496866254e-05 miRanda -0.120378698781622 1.19043706431733e-05 NA NA NA hsa-miR-106b-3p NFE2L2 1.74115042407425 7.96524575137272e-14 -0.965983722918669 1.89554271251606e-08 miRNAWalker2_validate -0.131708352471513 0.000181810407408059 NA NA NA hsa-miR-140-5p NFE2L2 0.844753502512594 3.73722278438606e-05 -0.965983722918669 1.89554271251606e-08 MirTarget;PITA;miRanda -0.153794517487273 0.000181411736238778 NA NA NA hsa-miR-338-3p NFE2L2 0.453166438193782 0.144583389707558 -0.965983722918669 1.89554271251606e-08 miRanda -0.105157709878824 0.000104420056573613 NA NA NA hsa-miR-361-5p NFE2L2 0.971859117235239 5.30236555707088e-09 -0.965983722918669 1.89554271251606e-08 miRanda -0.120778895511491 0.0171146889776627 NA NA NA hsa-miR-450b-5p NFE2L2 1.69244418548325 1.68064054148881e-10 -0.965983722918669 1.89554271251606e-08 PITA -0.130054999632121 2.86938393151595e-05 NA NA NA hsa-miR-500a-5p NFE2L2 1.72110365584658 3.0807246212659e-10 -0.965983722918669 1.89554271251606e-08 MirTarget -0.146879890619708 1.02026691214805e-06 NA NA NA hsa-miR-501-5p NFE2L2 1.93654809410041 1.3779381780759e-10 -0.965983722918669 1.89554271251606e-08 MirTarget -0.144473947807621 2.25692706080286e-07 NA NA NA hsa-miR-590-3p NFE2L2 2.59289455139753 1.03200520972022e-21 -0.965983722918669 1.89554271251606e-08 miRanda -0.117094784416117 0.000116362916834854 NA NA NA hsa-miR-7-1-3p NFE2L2 1.84950311431067 1.25300363397654e-13 -0.965983722918669 1.89554271251606e-08 MirTarget -0.108463627486486 0.000976256115198485 NA NA NA hsa-miR-101-3p NOTCH1 0.522819989585461 0.00375627731618038 -0.525528621196055 0.0318148804849282 MirTarget -0.144777408795411 0.0294490692942618 NA NA NA hsa-miR-18a-3p NOTCH1 2.14813400940323 2.23460809936028e-06 -0.525528621196055 0.0318148804849282 MirTarget -0.107047863569522 0.00100601356781471 NA NA NA hsa-miR-28-5p NOTCH1 0.230152919654905 0.0742909586754846 -0.525528621196055 0.0318148804849282 miRanda -0.369077331402684 9.33153738807782e-05 NA NA NA hsa-miR-30b-5p NOTCH1 0.800822374912712 0.000133601914525413 -0.525528621196055 0.0318148804849282 miRNATAP -0.117140312197032 0.0389913891192242 NA NA NA hsa-miR-32-5p NOTCH1 2.34056473219422 6.24134585974322e-20 -0.525528621196055 0.0318148804849282 miRNATAP -0.156587251260072 0.000397879604577739 NA NA NA hsa-miR-326 NOTCH1 0.715313016136042 0.0610265683213359 -0.525528621196055 0.0318148804849282 miRNAWalker2_validate;miRTarBase -0.137378974908137 8.96324701817683e-06 NA NA NA hsa-miR-92b-3p NOTCH1 1.20409245530001 3.41055816361655e-06 -0.525528621196055 0.0318148804849282 miRNATAP -0.134581909960881 0.00301080085178634 NA NA NA hsa-miR-103a-3p NOTCH2 1.44083190496858 1.53799939616416e-13 -0.649665466220466 0.00179668614494204 MirTarget -0.385027157118618 4.89264180444208e-15 NA NA NA hsa-miR-107 NOTCH2 1.30977326593435 1.30372468603965e-11 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.186403038708343 0.000277603211120417 NA NA NA hsa-miR-1226-3p NOTCH2 1.38118928579963 0.000205503474787488 -0.649665466220466 0.00179668614494204 MirTarget -0.180017706381832 3.06138695912041e-09 NA NA NA hsa-miR-125a-5p NOTCH2 0.599529391575274 0.0102300147180307 -0.649665466220466 0.00179668614494204 miRanda -0.285076782974206 1.95022168914584e-11 NA NA NA hsa-miR-126-5p NOTCH2 0.895338176458417 2.33372756450713e-05 -0.649665466220466 0.00179668614494204 mirMAP -0.139863687612872 0.0033475533373779 NA NA NA hsa-miR-1287-5p NOTCH2 0.712189050180771 0.00496124953411707 -0.649665466220466 0.00179668614494204 MirTarget -0.221253189180788 1.86802532818813e-08 NA NA NA hsa-miR-130b-5p NOTCH2 2.9963110846538 1.98883029416455e-18 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget -0.153835840036451 8.41323127308502e-08 NA NA NA hsa-miR-15a-5p NOTCH2 2.34669284378787 1.69544424500258e-23 -0.649665466220466 0.00179668614494204 MirTarget -0.24278405645845 1.52578738666268e-09 NA NA NA hsa-miR-15b-5p NOTCH2 1.57112623124278 9.14247846750597e-13 -0.649665466220466 0.00179668614494204 MirTarget -0.156336983702317 0.000490103910407743 NA NA NA hsa-miR-16-1-3p NOTCH2 2.56983217111073 3.02262181237943e-20 -0.649665466220466 0.00179668614494204 mirMAP -0.214011373235441 9.43694218750785e-10 NA NA NA hsa-miR-16-5p NOTCH2 1.75824877145857 1.68592440033108e-16 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget -0.14897245246307 0.00116209079289457 NA NA NA hsa-miR-17-5p NOTCH2 3.2710598467455 9.93128340539455e-27 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.152560497773471 6.83361684222724e-07 NA NA NA hsa-miR-181a-5p NOTCH2 2.29556023480783 1.8138457900616e-21 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget;mirMAP -0.143905947369735 0.000306255276064331 NA NA NA hsa-miR-181b-5p NOTCH2 2.49307679431293 3.92829250217627e-20 -0.649665466220466 0.00179668614494204 MirTarget;mirMAP -0.101485374256876 0.00437126750456582 NA NA NA hsa-miR-181c-5p NOTCH2 1.58587920618301 1.57506918816933e-10 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;MirTarget -0.200795801939749 3.99989183416027e-07 26983574;25494473 This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR-181c;Finally investigation of the mechanism defined Notch2 a key molecular of Notch signaling as the functional downstream target of miR-181c; An inverse correlation was found between miR-181c and Notch2 in glioma cells and verified in fresh glioma samples; miR-181c acts as a tumor suppressor that attenuates proliferation invasion and self-renewal capacities by downregulation of Notch2 in glioma cells ; glioblastoma;glioblastoma hsa-miR-181d-5p NOTCH2 1.52204912185579 9.2693319057748e-08 -0.649665466220466 0.00179668614494204 MirTarget -0.138792239818146 6.87384671317554e-05 NA NA NA hsa-miR-183-5p NOTCH2 4.19757025992371 4.79612296318304e-26 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.186602968297905 5.5780628899393e-16 NA NA NA hsa-miR-185-5p NOTCH2 2.34016206907488 1.17481626642022e-26 -0.649665466220466 0.00179668614494204 MirTarget -0.204552118195307 2.15972303784963e-06 NA NA NA hsa-miR-186-5p NOTCH2 1.47445398888668 3.0781726595413e-15 -0.649665466220466 0.00179668614494204 mirMAP -0.201441923529323 0.000127689480699954 NA NA NA hsa-miR-1976 NOTCH2 2.06550563678192 7.81396978619772e-18 -0.649665466220466 0.00179668614494204 MirTarget -0.124112621826353 0.00219527300042677 NA NA NA hsa-miR-200a-5p NOTCH2 3.86316681673704 1.81076942093171e-15 -0.649665466220466 0.00179668614494204 mirMAP -0.166597860648776 5.22317888688301e-18 NA NA NA hsa-miR-200b-5p NOTCH2 2.54484902707822 1.59240467582976e-06 -0.649665466220466 0.00179668614494204 mirMAP -0.127387401123288 9.89946271244752e-10 NA NA NA hsa-miR-218-5p NOTCH2 -0.573801507392184 0.0551983860126703 -0.649665466220466 0.00179668614494204 MirTarget -0.106706254879182 0.00156651729499553 NA NA NA hsa-miR-25-3p NOTCH2 1.36472605225697 4.83790725935681e-11 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.235507292382318 6.99856340019178e-07 NA NA NA hsa-miR-29b-3p NOTCH2 1.65828197923813 1.02676780888141e-09 -0.649665466220466 0.00179668614494204 MirTarget -0.181147718871655 5.5488985197182e-07 NA NA NA hsa-miR-29c-3p NOTCH2 -0.00968972577705429 0.97099586346872 -0.649665466220466 0.00179668614494204 MirTarget -0.239154701374818 1.53817800348435e-10 NA NA NA hsa-miR-30b-5p NOTCH2 0.800822374912712 0.000133601914525413 -0.649665466220466 0.00179668614494204 mirMAP -0.232727292147951 1.12596822430001e-06 NA NA NA hsa-miR-30c-5p NOTCH2 0.778774633108 0.000285599212429136 -0.649665466220466 0.00179668614494204 mirMAP -0.319400564697518 3.98998595021957e-12 NA NA NA hsa-miR-330-5p NOTCH2 1.15100069700871 4.85551805046014e-07 -0.649665466220466 0.00179668614494204 miRanda -0.154881641831788 0.000397591981275668 NA NA NA hsa-miR-33a-3p NOTCH2 1.72765312072219 1.51784443453521e-07 -0.649665466220466 0.00179668614494204 mirMAP -0.130723275459085 8.00200355591103e-05 NA NA NA hsa-miR-34a-5p NOTCH2 1.9016323452565 1.43092834643601e-14 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate;miRNATAP -0.276940453993645 8.61027725147104e-13 NA NA NA hsa-miR-421 NOTCH2 1.17791565395543 6.78526676976629e-06 -0.649665466220466 0.00179668614494204 miRanda -0.100618572129141 0.0088783333309056 NA NA NA hsa-miR-423-5p NOTCH2 0.963563145758616 9.86109015204915e-07 -0.649665466220466 0.00179668614494204 MirTarget -0.331032007834697 4.01952499018491e-11 NA NA NA hsa-miR-429 NOTCH2 4.48815175680773 2.44117492218206e-17 -0.649665466220466 0.00179668614494204 miRNATAP -0.151607627697974 6.20704896816715e-18 NA NA NA hsa-miR-590-5p NOTCH2 3.18300989862077 2.06813568597893e-26 -0.649665466220466 0.00179668614494204 miRanda -0.134955252568244 3.1234931315982e-05 NA NA NA hsa-miR-7-1-3p NOTCH2 1.84950311431067 1.25300363397654e-13 -0.649665466220466 0.00179668614494204 MirTarget;mirMAP -0.138111975343218 0.000445216009393343 NA NA NA hsa-miR-744-5p NOTCH2 1.48254348878737 3.23019501613577e-09 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.146204505023555 0.000223560181573343 NA NA NA hsa-miR-92a-3p NOTCH2 2.06460102658973 1.44784291084757e-19 -0.649665466220466 0.00179668614494204 miRNAWalker2_validate -0.191557194378095 5.6995060744795e-06 NA NA NA hsa-miR-940 NOTCH2 3.21011374578759 2.7923171128495e-14 -0.649665466220466 0.00179668614494204 MirTarget -0.115085878309908 4.5104844354942e-06 NA NA NA hsa-miR-491-5p NOTCH3 0.615770352820862 0.0418295628761654 0.786455013965519 0.000579502616355298 MirTarget;miRanda -0.10310021146103 0.00895021285053968 NA NA NA hsa-miR-146b-5p NOTCH4 1.75587235896724 1.15724631266659e-07 -0.509704073175338 0.0214592361813119 miRanda -0.129735010165571 4.42187299340442e-05 NA NA NA hsa-miR-18a-3p NOTCH4 2.14813400940323 2.23460809936028e-06 -0.509704073175338 0.0214592361813119 miRNAWalker2_validate -0.143718230978517 8.86443187862204e-07 NA NA NA hsa-miR-324-5p NOTCH4 2.95683728155095 1.32960514360912e-20 -0.509704073175338 0.0214592361813119 miRanda -0.113928614208281 0.000388468388728518 NA NA NA hsa-miR-330-5p NOTCH4 1.15100069700871 4.85551805046014e-07 -0.509704073175338 0.0214592361813119 miRanda -0.142811936693893 0.00215535579193378 NA NA NA hsa-miR-342-3p NOTCH4 1.49115144672245 1.43879249744621e-07 -0.509704073175338 0.0214592361813119 miRanda -0.14669655932954 8.13385781073728e-05 NA NA NA hsa-miR-421 NOTCH4 1.17791565395543 6.78526676976629e-06 -0.509704073175338 0.0214592361813119 miRanda -0.107575382553631 0.00845767149265075 NA NA NA hsa-let-7d-5p NSD1 1.33236798905207 1.1741085658466e-13 -0.140278049651839 0.313165028415798 miRNATAP -0.104375325008883 0.00439875920883422 NA NA NA hsa-let-7g-5p NSD1 1.20061455355116 1.50237505511483e-12 -0.140278049651839 0.313165028415798 miRNATAP -0.130888740155421 0.000766470600006302 NA NA NA hsa-let-7i-5p NSD1 0.412877696970403 0.00622731051981756 -0.140278049651839 0.313165028415798 miRNATAP -0.108760852317696 0.0163054502906792 NA NA NA hsa-miR-101-3p NSD1 0.522819989585461 0.00375627731618038 -0.140278049651839 0.313165028415798 MirTarget;miRNATAP -0.100425423307901 0.00744224224683472 NA NA NA hsa-miR-28-5p NSD1 0.230152919654905 0.0742909586754846 -0.140278049651839 0.313165028415798 miRanda -0.238767125484218 7.27100039317821e-06 NA NA NA hsa-miR-29b-3p NSD1 1.65828197923813 1.02676780888141e-09 -0.140278049651839 0.313165028415798 MirTarget;miRNATAP -0.135064280535963 1.59444930724105e-08 NA NA NA hsa-miR-29c-3p NSD1 -0.00968972577705429 0.97099586346872 -0.140278049651839 0.313165028415798 MirTarget;miRNATAP -0.114084322532755 5.35999920364276e-06 NA NA NA hsa-miR-30b-5p NSD1 0.800822374912712 0.000133601914525413 -0.140278049651839 0.313165028415798 mirMAP -0.112358555393067 0.000430847215702787 NA NA NA hsa-miR-30c-5p NSD1 0.778774633108 0.000285599212429136 -0.140278049651839 0.313165028415798 mirMAP;miRNATAP -0.156098696343118 4.53314983906451e-07 NA NA NA hsa-miR-34a-5p NSD1 1.9016323452565 1.43092834643601e-14 -0.140278049651839 0.313165028415798 miRNATAP -0.115584242688162 9.97030291056323e-06 NA NA NA hsa-miR-664a-5p NSD1 0.505019913598436 0.032933350691651 -0.140278049651839 0.313165028415798 MirTarget -0.134330708278641 2.03770731965667e-06 NA NA NA hsa-miR-107 NTRK2 1.30977326593435 1.30372468603965e-11 -3.4444884279512 9.02401971614574e-08 PITA;miRanda -1.10328807131129 2.46161403963682e-12 NA NA NA hsa-miR-125a-3p NTRK2 1.24490295132072 5.26925231010328e-06 -3.4444884279512 9.02401971614574e-08 miRanda -0.376033016875365 0.00107171920041796 NA NA NA hsa-miR-126-5p NTRK2 0.895338176458417 2.33372756450713e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.461947070179665 0.00199468881131289 NA NA NA hsa-miR-130b-3p NTRK2 3.5350292994509 1.73934183852569e-27 -3.4444884279512 9.02401971614574e-08 mirMAP -0.655009379767134 1.53407544109055e-13 NA NA NA hsa-miR-130b-5p NTRK2 2.9963110846538 1.98883029416455e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.664721546737953 6.35250159481337e-14 NA NA NA hsa-miR-151a-5p NTRK2 2.32422038747303 2.66226949101065e-18 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.871234808600496 3.71142225770198e-15 NA NA NA hsa-miR-15b-3p NTRK2 2.33847028227712 4.29662877950836e-19 -3.4444884279512 9.02401971614574e-08 mirMAP -0.78865263855268 3.47760542097815e-12 NA NA NA hsa-miR-17-3p NTRK2 2.2704817679209 1.1667437320211e-22 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.986404899520973 5.60866733893115e-15 NA NA NA hsa-miR-181a-5p NTRK2 2.29556023480783 1.8138457900616e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.641712336343684 2.29468859355526e-07 NA NA NA hsa-miR-181b-5p NTRK2 2.49307679431293 3.92829250217627e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.623644911740744 1.48869667340713e-08 NA NA NA hsa-miR-181c-5p NTRK2 1.58587920618301 1.57506918816933e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.487056006099362 9.7916777419054e-05 NA NA NA hsa-miR-182-5p NTRK2 3.53923166221814 5.07781258121574e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.542854638305866 3.89545557204651e-12 NA NA NA hsa-miR-185-5p NTRK2 2.34016206907488 1.17481626642022e-26 -3.4444884279512 9.02401971614574e-08 mirMAP -0.908221744534185 1.04154350912728e-11 NA NA NA hsa-miR-186-5p NTRK2 1.47445398888668 3.0781726595413e-15 -3.4444884279512 9.02401971614574e-08 mirMAP -1.08361132863423 2.28591646607224e-11 NA NA NA hsa-miR-200c-3p NTRK2 3.50132673580082 2.42716349086937e-15 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate;miRTarBase -0.558218294130396 5.1648144515451e-17 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-20a-3p NTRK2 2.92621109947706 2.49504904635375e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.638958030834559 4.2820526373737e-13 NA NA NA hsa-miR-21-5p NTRK2 2.73773305747971 1.38864982139576e-43 -3.4444884279512 9.02401971614574e-08 mirMAP -0.426222870969759 0.00330777931884449 NA NA NA hsa-miR-22-3p NTRK2 1.21545661147757 1.61670170137775e-13 -3.4444884279512 9.02401971614574e-08 miRNATAP -0.792113978350115 2.65895272261461e-05 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-224-3p NTRK2 1.87536386559317 6.15140969394846e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.251953296536257 0.000320280319633908 NA NA NA hsa-miR-26b-5p NTRK2 0.885393662798425 3.2116297961629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.918548097668709 2.31015434348151e-08 NA NA NA hsa-miR-29a-5p NTRK2 1.46749674755271 3.34605004270294e-07 -3.4444884279512 9.02401971614574e-08 mirMAP -0.413787908321922 0.000315700519378732 NA NA NA hsa-miR-301a-3p NTRK2 2.81024345929638 2.29784847962242e-17 -3.4444884279512 9.02401971614574e-08 mirMAP -0.744969523901533 2.39919848998948e-15 NA NA NA hsa-miR-3065-5p NTRK2 2.74629919868982 1.86846589298284e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.286324800403609 0.00023527787223171 NA NA NA hsa-miR-30b-5p NTRK2 0.800822374912712 0.000133601914525413 -3.4444884279512 9.02401971614574e-08 mirMAP -0.546689649319654 0.00029099120653431 NA NA NA hsa-miR-30c-5p NTRK2 0.778774633108 0.000285599212429136 -3.4444884279512 9.02401971614574e-08 mirMAP -0.689336493365858 2.58508921415882e-06 NA NA NA hsa-miR-30d-3p NTRK2 0.977747550180601 4.3048212205381e-05 -3.4444884279512 9.02401971614574e-08 mirMAP -0.665503813522632 3.72555641617031e-07 NA NA NA hsa-miR-30d-5p NTRK2 0.675423997639582 0.00270618816039773 -3.4444884279512 9.02401971614574e-08 mirMAP -0.687091926033502 8.8466750322348e-07 NA NA NA hsa-miR-30e-3p NTRK2 -0.215663037684509 0.235375122783546 -3.4444884279512 9.02401971614574e-08 mirMAP -0.560142851781332 0.00151121456503575 NA NA NA hsa-miR-30e-5p NTRK2 1.23904909539663 1.35561917122157e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.997379711717577 3.00290798335836e-11 NA NA NA hsa-miR-32-3p NTRK2 2.02436999565685 5.94091197945307e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.59869849424457 2.50361692819518e-09 NA NA NA hsa-miR-32-5p NTRK2 2.34056473219422 6.24134585974322e-20 -3.4444884279512 9.02401971614574e-08 mirMAP -0.794984558850216 6.67646054442438e-12 NA NA NA hsa-miR-320a NTRK2 0.438165828017084 0.0390159073347133 -3.4444884279512 9.02401971614574e-08 mirMAP -0.708471038497037 2.00258734327495e-06 NA NA NA hsa-miR-320b NTRK2 1.55692969039548 1.41071034251915e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.748159964114521 1.79959199577157e-11 NA NA NA hsa-miR-326 NTRK2 0.715313016136042 0.0610265683213359 -3.4444884279512 9.02401971614574e-08 miRanda -0.314908565253097 0.000146783251679974 NA NA NA hsa-miR-330-5p NTRK2 1.15100069700871 4.85551805046014e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.797396566610236 3.87824675584644e-09 NA NA NA hsa-miR-335-3p NTRK2 3.08791651139852 5.31309869723517e-12 -3.4444884279512 9.02401971614574e-08 mirMAP -0.325799033294531 1.77950710082574e-06 NA NA NA hsa-miR-335-5p NTRK2 1.77247705492746 2.22457658872091e-06 -3.4444884279512 9.02401971614574e-08 miRNAWalker2_validate -0.306339245672051 0.000234367118729164 NA NA NA hsa-miR-339-5p NTRK2 2.68710938429893 3.03134080808154e-16 -3.4444884279512 9.02401971614574e-08 miRanda -0.473102823273484 2.60419080375085e-07 NA NA NA hsa-miR-33a-5p NTRK2 3.79671563098419 1.15966309820345e-18 -3.4444884279512 9.02401971614574e-08 mirMAP -0.446714130551512 3.20996972838069e-09 NA NA NA hsa-miR-342-3p NTRK2 1.49115144672245 1.43879249744621e-07 -3.4444884279512 9.02401971614574e-08 miRanda -0.232236997607975 0.0357997421714086 NA NA NA hsa-miR-34a-3p NTRK2 1.75590866103657 8.02801510630657e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.545493213319934 1.33340706209908e-06 NA NA NA hsa-miR-361-5p NTRK2 0.971859117235239 5.30236555707088e-09 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -1.17870891609401 2.52271895231875e-10 NA NA NA hsa-miR-362-5p NTRK2 1.59303749908759 9.582675908797e-08 -3.4444884279512 9.02401971614574e-08 mirMAP -0.34256739087268 0.0010450304175508 NA NA NA hsa-miR-421 NTRK2 1.17791565395543 6.78526676976629e-06 -3.4444884279512 9.02401971614574e-08 mirMAP -0.388652077576734 0.00124164792398222 NA NA NA hsa-miR-429 NTRK2 4.48815175680773 2.44117492218206e-17 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;miRNATAP -0.439212754909065 2.46588001463114e-15 NA NA NA hsa-miR-452-3p NTRK2 2.42521958420768 4.08754552781156e-07 -3.4444884279512 9.02401971614574e-08 mirMAP -0.16566953481693 0.0114315822356794 NA NA NA hsa-miR-454-3p NTRK2 2.47234127820054 1.12878018736016e-21 -3.4444884279512 9.02401971614574e-08 mirMAP -0.84994308142847 3.69480447340161e-13 NA NA NA hsa-miR-455-3p NTRK2 3.06093594997644 3.54590649799868e-16 -3.4444884279512 9.02401971614574e-08 mirMAP -0.417652226788031 2.01737423577491e-07 NA NA NA hsa-miR-501-5p NTRK2 1.93654809410041 1.3779381780759e-10 -3.4444884279512 9.02401971614574e-08 mirMAP -0.515062812169395 9.14107888272414e-07 NA NA NA hsa-miR-532-5p NTRK2 1.55697650978597 1.57884735535196e-11 -3.4444884279512 9.02401971614574e-08 PITA -0.662294968429731 6.6852568807782e-07 NA NA NA hsa-miR-576-5p NTRK2 2.20467023993664 3.4053475193793e-19 -3.4444884279512 9.02401971614574e-08 PITA;mirMAP -0.790847254437626 6.52457580482194e-11 NA NA NA hsa-miR-590-3p NTRK2 2.59289455139753 1.03200520972022e-21 -3.4444884279512 9.02401971614574e-08 PITA;miRanda;mirMAP -0.620306339153694 4.06542783004907e-08 NA NA NA hsa-miR-590-5p NTRK2 3.18300989862077 2.06813568597893e-26 -3.4444884279512 9.02401971614574e-08 miRanda;mirMAP -0.735662775454248 1.39412676341035e-13 NA NA NA hsa-miR-940 NTRK2 3.21011374578759 2.7923171128495e-14 -3.4444884279512 9.02401971614574e-08 PITA -0.574117798651102 9.91369577061371e-14 NA NA NA hsa-let-7a-3p NTRK3 1.42015538786275 7.03375209382654e-13 -5.17034960965042 5.23662623079398e-21 mirMAP -0.843494731671022 6.17732694000986e-10 NA NA NA hsa-let-7a-5p NTRK3 0.618599506841644 2.76973453058748e-05 -5.17034960965042 5.23662623079398e-21 mirMAP -0.779252866501379 4.60348738745268e-05 NA NA NA hsa-let-7b-3p NTRK3 0.868207752019623 1.30460056774366e-05 -5.17034960965042 5.23662623079398e-21 mirMAP -0.955887340867188 3.27173554363463e-12 NA NA NA hsa-let-7b-5p NTRK3 0.604314269683977 0.00140009936153214 -5.17034960965042 5.23662623079398e-21 mirMAP -0.776849273580379 1.32319468309959e-07 NA NA NA hsa-let-7d-5p NTRK3 1.33236798905207 1.1741085658466e-13 -5.17034960965042 5.23662623079398e-21 mirMAP -1.05855917586917 1.35558285380503e-12 NA NA NA hsa-let-7e-5p NTRK3 0.860104282510173 6.04758298373779e-05 -5.17034960965042 5.23662623079398e-21 mirMAP -0.360278310144356 0.0057687891717852 NA NA NA hsa-let-7f-1-3p NTRK3 1.55054488387679 7.31326775537952e-11 -5.17034960965042 5.23662623079398e-21 mirMAP -0.756290346546449 8.34951704299748e-11 NA NA NA hsa-let-7g-5p NTRK3 1.20061455355116 1.50237505511483e-12 -5.17034960965042 5.23662623079398e-21 mirMAP -0.845323932819879 1.49943660252162e-07 NA NA NA hsa-miR-106a-5p NTRK3 2.48882002962836 1.99757727374521e-12 -5.17034960965042 5.23662623079398e-21 mirMAP -0.562177832557014 5.56583014007757e-14 NA NA NA hsa-miR-106b-5p NTRK3 2.46782146831112 1.36171495805632e-23 -5.17034960965042 5.23662623079398e-21 mirMAP -0.879633282339711 2.38151397200134e-17 NA NA NA hsa-miR-10a-5p NTRK3 1.15016989191194 0.00372037233992369 -5.17034960965042 5.23662623079398e-21 mirMAP -0.141828539548441 0.0439705580349762 NA NA NA hsa-miR-10b-3p NTRK3 0.77597971642517 0.00264877454133753 -5.17034960965042 5.23662623079398e-21 mirMAP -0.328259643476887 0.00244195116981908 NA NA NA hsa-miR-125a-3p NTRK3 1.24490295132072 5.26925231010328e-06 -5.17034960965042 5.23662623079398e-21 mirMAP -0.302361597389883 0.00292953719193252 NA NA NA hsa-miR-128-3p NTRK3 1.63756041666078 6.79626586407187e-14 -5.17034960965042 5.23662623079398e-21 miRNAWalker2_validate;miRTarBase -0.912252045454602 5.89469876751634e-14 NA NA NA hsa-miR-135b-5p NTRK3 3.62510365056501 1.09148980810091e-10 -5.17034960965042 5.23662623079398e-21 mirMAP -0.381900167649362 2.23211376822015e-14 NA NA NA hsa-miR-141-3p NTRK3 5.02396127982626 2.19224509139725e-24 -5.17034960965042 5.23662623079398e-21 mirMAP -0.496811560602054 1.26226870960282e-22 NA NA NA hsa-miR-151a-3p NTRK3 1.24018761527407 1.08839919675408e-07 -5.17034960965042 5.23662623079398e-21 miRNAWalker2_validate;miRTarBase -0.735932520103227 2.6903751192207e-10 NA NA NA hsa-miR-15b-3p NTRK3 2.33847028227712 4.29662877950836e-19 -5.17034960965042 5.23662623079398e-21 mirMAP -0.979990639007781 5.79590541216155e-24 NA NA NA hsa-miR-17-5p NTRK3 3.2710598467455 9.93128340539455e-27 -5.17034960965042 5.23662623079398e-21 mirMAP -0.772176968989673 4.62851766903496e-21 NA NA NA hsa-miR-181a-2-3p NTRK3 2.19062681262366 3.81790102612782e-13 -5.17034960965042 5.23662623079398e-21 mirMAP -0.471731771867866 1.21617476908672e-07 NA NA NA hsa-miR-182-5p NTRK3 3.53923166221814 5.07781258121574e-21 -5.17034960965042 5.23662623079398e-21 mirMAP -0.494727844384687 7.13881547217231e-13 NA NA NA hsa-miR-185-5p NTRK3 2.34016206907488 1.17481626642022e-26 -5.17034960965042 5.23662623079398e-21 miRNAWalker2_validate;miRTarBase;mirMAP -1.07467831905159 1.0643697748755e-20 NA NA NA hsa-miR-186-5p NTRK3 1.47445398888668 3.0781726595413e-15 -5.17034960965042 5.23662623079398e-21 mirMAP -1.0076087658778 1.64514373678116e-12 NA NA NA hsa-miR-18a-5p NTRK3 3.78535678765353 3.72446596213886e-26 -5.17034960965042 5.23662623079398e-21 mirMAP -0.624450638889005 7.417030279259e-17 NA NA NA hsa-miR-192-5p NTRK3 2.69002528723195 1.22990188194432e-16 -5.17034960965042 5.23662623079398e-21 mirMAP -0.516975564619067 2.11064593821759e-10 NA NA NA hsa-miR-193a-5p NTRK3 0.562511612963676 0.0239254699649222 -5.17034960965042 5.23662623079398e-21 mirMAP -0.288855652079207 0.0104300849743409 NA NA NA hsa-miR-194-5p NTRK3 1.8992998339217 3.76507853301977e-10 -5.17034960965042 5.23662623079398e-21 mirMAP -0.357494409386878 7.16332837998809e-05 NA NA NA hsa-miR-19a-3p NTRK3 3.42309334186656 3.02671914353412e-28 -5.17034960965042 5.23662623079398e-21 mirMAP -0.689054591426502 2.00377651656457e-17 NA NA NA hsa-miR-19b-1-5p NTRK3 2.57951428759379 4.31576118703427e-20 -5.17034960965042 5.23662623079398e-21 mirMAP -0.785034580950879 9.0589770273599e-17 NA NA NA hsa-miR-19b-3p NTRK3 2.49529833021187 1.57028265846699e-23 -5.17034960965042 5.23662623079398e-21 mirMAP -0.851142752495317 1.15561053790892e-16 NA NA NA hsa-miR-200a-3p NTRK3 4.59434485520731 6.38952518573476e-18 -5.17034960965042 5.23662623079398e-21 mirMAP -0.331828050108212 1.47208806360773e-11 NA NA NA hsa-miR-200a-5p NTRK3 3.86316681673704 1.81076942093171e-15 -5.17034960965042 5.23662623079398e-21 mirMAP -0.369389629661375 9.78946011032232e-12 NA NA NA hsa-miR-200b-5p NTRK3 2.54484902707822 1.59240467582976e-06 -5.17034960965042 5.23662623079398e-21 mirMAP -0.383162176328861 2.68173323099184e-11 NA NA NA hsa-miR-205-5p NTRK3 4.1389800495524 2.05488295686453e-12 -5.17034960965042 5.23662623079398e-21 mirMAP -0.428306939742473 1.44402647219024e-22 NA NA NA hsa-miR-20a-3p NTRK3 2.92621109947706 2.49504904635375e-17 -5.17034960965042 5.23662623079398e-21 mirMAP -0.605031223009403 5.80986159862503e-15 NA NA NA hsa-miR-20a-5p NTRK3 3.15577933619191 4.19753346442454e-25 -5.17034960965042 5.23662623079398e-21 mirMAP -0.692981728682094 1.032713099107e-16 NA NA NA hsa-miR-20b-5p NTRK3 2.07706563022469 1.10107236083433e-05 -5.17034960965042 5.23662623079398e-21 mirMAP -0.272427278011153 2.66792882481777e-06 NA NA NA hsa-miR-21-3p NTRK3 2.19296355304364 4.63665722759779e-15 -5.17034960965042 5.23662623079398e-21 mirMAP -0.796322245487941 1.3518610233648e-17 NA NA NA hsa-miR-21-5p NTRK3 2.73773305747971 1.38864982139576e-43 -5.17034960965042 5.23662623079398e-21 mirMAP -0.975689568168568 4.00433841891372e-15 NA NA NA hsa-miR-22-3p NTRK3 1.21545661147757 1.61670170137775e-13 -5.17034960965042 5.23662623079398e-21 mirMAP -0.703654562899358 2.37647658502366e-05 NA NA NA hsa-miR-22-5p NTRK3 1.88011544159252 1.63978222572222e-16 -5.17034960965042 5.23662623079398e-21 mirMAP -0.517429531249704 1.17397050653565e-05 NA NA NA hsa-miR-222-5p NTRK3 1.25632771414778 0.000138653440511922 -5.17034960965042 5.23662623079398e-21 mirMAP -0.471211324950048 1.43787354929799e-08 NA NA NA hsa-miR-24-2-5p NTRK3 2.07171035460647 3.15853539996136e-16 -5.17034960965042 5.23662623079398e-21 mirMAP -0.657205039713487 3.50833512003292e-10 NA NA NA hsa-miR-25-3p NTRK3 1.36472605225697 4.83790725935681e-11 -5.17034960965042 5.23662623079398e-21 mirMAP -0.682536079513171 2.01188675372278e-07 NA NA NA hsa-miR-26b-5p NTRK3 0.885393662798425 3.2116297961629e-06 -5.17034960965042 5.23662623079398e-21 mirMAP -0.630733243299632 1.61698592599694e-05 NA NA NA hsa-miR-3065-5p NTRK3 2.74629919868982 1.86846589298284e-08 -5.17034960965042 5.23662623079398e-21 mirMAP -0.352095350461647 2.45791180839453e-07 NA NA NA hsa-miR-30d-5p NTRK3 0.675423997639582 0.00270618816039773 -5.17034960965042 5.23662623079398e-21 mirMAP -0.246018072505079 0.0489108482945389 NA NA NA hsa-miR-30e-5p NTRK3 1.23904909539663 1.35561917122157e-09 -5.17034960965042 5.23662623079398e-21 mirMAP -0.592443472648753 1.05207762702012e-05 NA NA NA hsa-miR-32-3p NTRK3 2.02436999565685 5.94091197945307e-09 -5.17034960965042 5.23662623079398e-21 mirMAP -0.534636775584206 1.63007809401936e-09 NA NA NA hsa-miR-32-5p NTRK3 2.34056473219422 6.24134585974322e-20 -5.17034960965042 5.23662623079398e-21 mirMAP -0.56767123969486 3.88768501518392e-08 NA NA NA hsa-miR-320a NTRK3 0.438165828017084 0.0390159073347133 -5.17034960965042 5.23662623079398e-21 mirMAP -0.269223242448341 0.0430620369240206 NA NA NA hsa-miR-320b NTRK3 1.55692969039548 1.41071034251915e-08 -5.17034960965042 5.23662623079398e-21 mirMAP -0.664942645354684 1.31522240360779e-11 NA NA NA hsa-miR-324-5p NTRK3 2.95683728155095 1.32960514360912e-20 -5.17034960965042 5.23662623079398e-21 PITA;miRanda;mirMAP -0.597709813903424 2.62719328985864e-13 NA NA NA hsa-miR-330-3p NTRK3 0.876747334239085 0.00073709016089703 -5.17034960965042 5.23662623079398e-21 miRNAWalker2_validate -0.447023909884978 2.93017737259416e-05 NA NA NA hsa-miR-331-5p NTRK3 2.17414714166315 1.54547681391888e-18 -5.17034960965042 5.23662623079398e-21 mirMAP -1.05183445531935 3.53066346550548e-23 NA NA NA hsa-miR-335-3p NTRK3 3.08791651139852 5.31309869723517e-12 -5.17034960965042 5.23662623079398e-21 mirMAP -0.234486060607249 0.000106465700929899 NA NA NA hsa-miR-345-5p NTRK3 3.63532310411307 2.2698112107996e-21 -5.17034960965042 5.23662623079398e-21 miRNAWalker2_validate -0.598118754847201 2.39397585582006e-19 NA NA NA hsa-miR-34a-3p NTRK3 1.75590866103657 8.02801510630657e-09 -5.17034960965042 5.23662623079398e-21 mirMAP -0.410313404824883 4.09349897404522e-05 NA NA NA hsa-miR-34c-3p NTRK3 2.41359195938096 3.46966584087088e-10 -5.17034960965042 5.23662623079398e-21 mirMAP;miRNATAP -0.43160278413965 2.80184833201557e-09 NA NA NA hsa-miR-34c-5p NTRK3 2.07190852984647 7.35776320806257e-08 -5.17034960965042 5.23662623079398e-21 miRanda -0.357284421114983 2.3679739916676e-06 NA NA NA hsa-miR-361-5p NTRK3 0.971859117235239 5.30236555707088e-09 -5.17034960965042 5.23662623079398e-21 mirMAP -1.00249243893382 1.19245950057573e-09 NA NA NA hsa-miR-3613-5p NTRK3 2.64358387329263 1.0373753017245e-24 -5.17034960965042 5.23662623079398e-21 miRNATAP -0.848330000425339 8.23852914689657e-17 NA NA NA hsa-miR-363-3p NTRK3 1.50575300026701 0.00020976164678918 -5.17034960965042 5.23662623079398e-21 mirMAP -0.296287165293091 1.30957438324202e-05 NA NA NA hsa-miR-378a-3p NTRK3 -0.10995720000828 0.716188270032681 -5.17034960965042 5.23662623079398e-21 mirMAP -0.227473736515962 0.0143375596523132 NA NA NA hsa-miR-378a-5p NTRK3 0.223456081148306 0.386368843153575 -5.17034960965042 5.23662623079398e-21 mirMAP -0.314660623008946 0.00388919119676946 NA NA NA hsa-miR-3913-5p NTRK3 2.44353493655328 8.95279496632448e-15 -5.17034960965042 5.23662623079398e-21 mirMAP -0.39941288021127 5.46361148229622e-06 NA NA NA hsa-miR-421 NTRK3 1.17791565395543 6.78526676976629e-06 -5.17034960965042 5.23662623079398e-21 mirMAP -0.58078178273917 3.21430054328668e-08 NA NA NA hsa-miR-423-5p NTRK3 0.963563145758616 9.86109015204915e-07 -5.17034960965042 5.23662623079398e-21 PITA -0.783852856203668 2.08630806480432e-08 NA NA NA hsa-miR-452-5p NTRK3 1.37180058737183 0.00171494843537772 -5.17034960965042 5.23662623079398e-21 mirMAP -0.287174310093116 5.3168474983995e-06 NA NA NA hsa-miR-455-3p NTRK3 3.06093594997644 3.54590649799868e-16 -5.17034960965042 5.23662623079398e-21 mirMAP -0.636704223813581 1.5988256282515e-20 NA NA NA hsa-miR-455-5p NTRK3 2.2582442061694 1.43472128037398e-13 -5.17034960965042 5.23662623079398e-21 miRanda -0.450334657232625 3.1284998599119e-07 NA NA NA hsa-miR-500a-5p NTRK3 1.72110365584658 3.0807246212659e-10 -5.17034960965042 5.23662623079398e-21 mirMAP -0.370857987503418 0.000214881672127131 NA NA NA hsa-miR-505-3p NTRK3 1.45322244209148 8.86597629645867e-10 -5.17034960965042 5.23662623079398e-21 mirMAP -0.746755896312317 5.45835844669765e-11 NA NA NA hsa-miR-532-5p NTRK3 1.55697650978597 1.57884735535196e-11 -5.17034960965042 5.23662623079398e-21 mirMAP -0.500565936965655 2.2657355290337e-05 NA NA NA hsa-miR-542-3p NTRK3 1.18832665895751 1.98700670691565e-07 -5.17034960965042 5.23662623079398e-21 miRanda -0.280513540867947 0.0211275374525668 NA NA NA hsa-miR-576-5p NTRK3 2.20467023993664 3.4053475193793e-19 -5.17034960965042 5.23662623079398e-21 mirMAP -0.941652732418398 2.17752565172969e-19 NA NA NA hsa-miR-584-5p NTRK3 2.7326672683732 9.92677936962233e-12 -5.17034960965042 5.23662623079398e-21 mirMAP -0.512134780942594 7.10861943967634e-15 NA NA NA hsa-miR-589-3p NTRK3 2.51971841868825 2.39125940264107e-11 -5.17034960965042 5.23662623079398e-21 mirMAP -0.527353618226715 6.6211694006498e-11 NA NA NA hsa-miR-590-3p NTRK3 2.59289455139753 1.03200520972022e-21 -5.17034960965042 5.23662623079398e-21 mirMAP -0.728998175833023 1.26623206569484e-13 NA NA NA hsa-miR-590-5p NTRK3 3.18300989862077 2.06813568597893e-26 -5.17034960965042 5.23662623079398e-21 mirMAP -0.737351473474608 2.27039147627811e-17 NA NA NA hsa-miR-624-5p NTRK3 1.47043111118159 8.25080691741182e-09 -5.17034960965042 5.23662623079398e-21 mirMAP -0.598244949645114 7.06036288970107e-08 NA NA NA hsa-miR-625-3p NTRK3 1.18769734290812 2.47200238827911e-06 -5.17034960965042 5.23662623079398e-21 mirMAP -0.424674671754793 0.000108585498399987 NA NA NA hsa-miR-625-5p NTRK3 1.42540152147292 1.95797147911206e-06 -5.17034960965042 5.23662623079398e-21 miRNAWalker2_validate;mirMAP -0.488100822487114 1.24314820487926e-06 NA NA NA hsa-miR-629-3p NTRK3 2.36570947321815 1.33458201201618e-11 -5.17034960965042 5.23662623079398e-21 mirMAP -0.728193489973175 1.0493325548959e-17 NA NA NA hsa-miR-660-5p NTRK3 1.82692095272076 1.92040083607196e-13 -5.17034960965042 5.23662623079398e-21 mirMAP -0.326069536430198 0.00296344775588939 NA NA NA hsa-miR-7-1-3p NTRK3 1.84950311431067 1.25300363397654e-13 -5.17034960965042 5.23662623079398e-21 mirMAP -0.68972365766013 1.19197812603374e-10 NA NA NA hsa-miR-708-3p NTRK3 2.80907765282502 3.07460722669281e-14 -5.17034960965042 5.23662623079398e-21 mirMAP -0.189481126023688 0.00971353864294107 NA NA NA hsa-miR-708-5p NTRK3 3.38051631555486 5.12590198690777e-18 -5.17034960965042 5.23662623079398e-21 mirMAP -0.264793679956677 0.00010594308520104 NA NA NA hsa-miR-744-3p NTRK3 2.7517405670917 4.22040908411227e-14 -5.17034960965042 5.23662623079398e-21 mirMAP -0.677710946602591 1.11812604989502e-21 NA NA NA hsa-miR-769-5p NTRK3 1.82023760596845 9.6815886564134e-14 -5.17034960965042 5.23662623079398e-21 miRNATAP -0.656273477517736 2.1908138079287e-09 NA NA NA hsa-miR-877-5p NTRK3 2.94916202082736 1.8151927276044e-13 -5.17034960965042 5.23662623079398e-21 mirMAP -0.601761841673718 3.66335014380257e-16 NA NA NA hsa-miR-92a-3p NTRK3 2.06460102658973 1.44784291084757e-19 -5.17034960965042 5.23662623079398e-21 mirMAP -1.07634929879647 8.54731036107335e-22 NA NA NA hsa-miR-92b-3p NTRK3 1.20409245530001 3.41055816361655e-06 -5.17034960965042 5.23662623079398e-21 mirMAP -0.468874657484007 1.05260431129356e-05 NA NA NA hsa-miR-93-3p NTRK3 2.85383869771942 5.64481766902125e-23 -5.17034960965042 5.23662623079398e-21 mirMAP -0.77662674865616 1.22478771702732e-18 NA NA NA hsa-miR-93-5p NTRK3 3.03961860136032 1.11672209617395e-24 -5.17034960965042 5.23662623079398e-21 mirMAP -0.683520697470751 2.3975737947163e-15 NA NA NA hsa-miR-940 NTRK3 3.21011374578759 2.7923171128495e-14 -5.17034960965042 5.23662623079398e-21 miRNATAP -0.544361031609655 9.53070085520253e-16 NA NA NA hsa-miR-944 NTRK3 2.91186649218281 1.31574753528144e-06 -5.17034960965042 5.23662623079398e-21 mirMAP -0.406901079230097 2.89968477537395e-19 NA NA NA hsa-miR-96-5p NTRK3 4.89433085814374 1.92000659886961e-31 -5.17034960965042 5.23662623079398e-21 mirMAP -0.535831719585397 1.32014488017279e-18 NA NA NA hsa-miR-98-5p NTRK3 1.11154309866014 1.24143909012085e-08 -5.17034960965042 5.23662623079398e-21 mirMAP -0.755080690304688 7.82563896958091e-08 NA NA NA hsa-miR-99b-3p NTRK3 1.62436885280973 8.09988670773273e-10 -5.17034960965042 5.23662623079398e-21 mirMAP -0.583756103153715 1.24430046809639e-08 NA NA NA hsa-let-7e-5p PAK1 0.860104282510173 6.04758298373779e-05 -0.260585931173264 0.175229696873286 miRNATAP -0.1369917481953 0.00153436045412213 NA NA NA hsa-miR-106b-5p PARK2 2.46782146831112 1.36171495805632e-23 -2.98125538061649 5.34110722830798e-14 mirMAP -0.52955679963998 1.06108749083878e-12 NA NA NA hsa-miR-107 PARK2 1.30977326593435 1.30372468603965e-11 -2.98125538061649 5.34110722830798e-14 miRanda -0.490694422746937 8.90854946943434e-07 NA NA NA hsa-miR-125a-3p PARK2 1.24490295132072 5.26925231010328e-06 -2.98125538061649 5.34110722830798e-14 miRanda -0.366664181632613 2.57190038312544e-07 NA NA NA hsa-miR-140-5p PARK2 0.844753502512594 3.73722278438606e-05 -2.98125538061649 5.34110722830798e-14 miRanda -0.437820511288685 5.05827638515387e-06 NA NA NA hsa-miR-146b-5p PARK2 1.75587235896724 1.15724631266659e-07 -2.98125538061649 5.34110722830798e-14 miRanda -0.510776155034633 1.37075132993414e-19 NA NA NA hsa-miR-20a-5p PARK2 3.15577933619191 4.19753346442454e-25 -2.98125538061649 5.34110722830798e-14 mirMAP -0.463731915265865 5.47447053838051e-15 NA NA NA hsa-miR-26b-5p PARK2 0.885393662798425 3.2116297961629e-06 -2.98125538061649 5.34110722830798e-14 miRNAWalker2_validate;mirMAP -0.450405361503247 1.34303313239473e-05 NA NA NA hsa-miR-32-3p PARK2 2.02436999565685 5.94091197945307e-09 -2.98125538061649 5.34110722830798e-14 mirMAP -0.292266082317212 3.86123311840902e-06 NA NA NA hsa-miR-320b PARK2 1.55692969039548 1.41071034251915e-08 -2.98125538061649 5.34110722830798e-14 miRanda -0.38225454245068 5.13770851538197e-08 NA NA NA hsa-miR-335-3p PARK2 3.08791651139852 5.31309869723517e-12 -2.98125538061649 5.34110722830798e-14 mirMAP -0.183903276795224 1.67304759858974e-05 NA NA NA hsa-miR-335-5p PARK2 1.77247705492746 2.22457658872091e-06 -2.98125538061649 5.34110722830798e-14 miRNAWalker2_validate -0.132236704757178 0.0113806170430022 NA NA NA hsa-miR-429 PARK2 4.48815175680773 2.44117492218206e-17 -2.98125538061649 5.34110722830798e-14 miRanda -0.103383550125821 0.00386986163376162 NA NA NA hsa-miR-532-5p PARK2 1.55697650978597 1.57884735535196e-11 -2.98125538061649 5.34110722830798e-14 mirMAP -0.393365874468178 2.38445996738809e-06 NA NA NA hsa-miR-590-3p PARK2 2.59289455139753 1.03200520972022e-21 -2.98125538061649 5.34110722830798e-14 miRanda;mirMAP -0.674980805611629 2.65387408754357e-23 NA NA NA hsa-miR-103a-3p PAX5 1.44083190496858 1.53799939616416e-13 -1.22891527233864 0.0475460185287537 mirMAP -0.754582033365007 4.41329079506329e-07 NA NA NA hsa-miR-106b-5p PAX5 2.46782146831112 1.36171495805632e-23 -1.22891527233864 0.0475460185287537 mirMAP -0.396100589383296 0.000604281373226121 NA NA NA hsa-miR-107 PAX5 1.30977326593435 1.30372468603965e-11 -1.22891527233864 0.0475460185287537 mirMAP -0.365773264082476 0.017001791060187 NA NA NA hsa-miR-10a-5p PAX5 1.15016989191194 0.00372037233992369 -1.22891527233864 0.0475460185287537 mirMAP -0.311215783769321 3.37217753093346e-05 NA NA NA hsa-miR-10b-3p PAX5 0.77597971642517 0.00264877454133753 -1.22891527233864 0.0475460185287537 mirMAP -0.402983580118392 0.000522345262819018 NA NA NA hsa-miR-10b-5p PAX5 -0.155951595811628 0.555006386998027 -1.22891527233864 0.0475460185287537 mirMAP -0.268152855244858 0.0191745734125015 NA NA NA hsa-miR-1226-3p PAX5 1.38118928579963 0.000205503474787488 -1.22891527233864 0.0475460185287537 mirMAP -0.259867085988113 0.00464874205172493 NA NA NA hsa-miR-125a-5p PAX5 0.599529391575274 0.0102300147180307 -1.22891527233864 0.0475460185287537 mirMAP -0.651349156077003 3.49048895564595e-07 NA NA NA hsa-miR-141-5p PAX5 3.81419396518882 3.21977359736126e-18 -1.22891527233864 0.0475460185287537 mirMAP -0.309488797229805 1.96351681291126e-06 NA NA NA hsa-miR-148b-5p PAX5 2.18024067300781 2.84770452413262e-14 -1.22891527233864 0.0475460185287537 mirMAP -0.589869153122284 2.77616223358968e-08 NA NA NA hsa-miR-15a-5p PAX5 2.34669284378787 1.69544424500258e-23 -1.22891527233864 0.0475460185287537 mirMAP -0.544457457168144 6.47610158539274e-06 NA NA NA hsa-miR-15b-5p PAX5 1.57112623124278 9.14247846750597e-13 -1.22891527233864 0.0475460185287537 mirMAP -0.376962207219285 0.00483513084794526 NA NA NA hsa-miR-17-5p PAX5 3.2710598467455 9.93128340539455e-27 -1.22891527233864 0.0475460185287537 mirMAP -0.395570790202928 1.61932723517169e-05 NA NA NA hsa-miR-181a-2-3p PAX5 2.19062681262366 3.81790102612782e-13 -1.22891527233864 0.0475460185287537 mirMAP -0.308420117367194 0.00143954307402209 NA NA NA hsa-miR-181c-3p PAX5 2.12243544912484 2.25156887166019e-14 -1.22891527233864 0.0475460185287537 mirMAP -0.433106249592371 3.33233518275549e-05 NA NA NA hsa-miR-183-5p PAX5 4.19757025992371 4.79612296318304e-26 -1.22891527233864 0.0475460185287537 mirMAP -0.338752415277998 1.43531898453812e-06 NA NA NA hsa-miR-19b-1-5p PAX5 2.57951428759379 4.31576118703427e-20 -1.22891527233864 0.0475460185287537 mirMAP -0.245155213610976 0.0198462287199908 NA NA NA hsa-miR-20a-5p PAX5 3.15577933619191 4.19753346442454e-25 -1.22891527233864 0.0475460185287537 mirMAP -0.40321938550311 1.25672811363323e-05 NA NA NA hsa-miR-2110 PAX5 1.16625590651194 6.4784195289885e-05 -1.22891527233864 0.0475460185287537 mirMAP -0.500962805403667 4.47905983660672e-06 NA NA NA hsa-miR-22-3p PAX5 1.21545661147757 1.61670170137775e-13 -1.22891527233864 0.0475460185287537 mirMAP -0.492660870153076 0.00618726720205092 NA NA NA hsa-miR-224-3p PAX5 1.87536386559317 6.15140969394846e-05 -1.22891527233864 0.0475460185287537 mirMAP -0.393815758701499 1.85560829695373e-09 NA NA NA hsa-miR-224-5p PAX5 2.94107125335675 5.72194099515157e-08 -1.22891527233864 0.0475460185287537 mirMAP -0.297227257601488 3.15503496041283e-08 NA NA NA hsa-miR-23a-3p PAX5 1.00493340843378 2.55313889288924e-08 -1.22891527233864 0.0475460185287537 mirMAP -0.540906094479145 0.00109909646754278 NA NA NA hsa-miR-27b-5p PAX5 0.393316367667332 0.051702301924024 -1.22891527233864 0.0475460185287537 mirMAP -0.499335797912335 0.000854235103932381 NA NA NA hsa-miR-28-5p PAX5 0.230152919654905 0.0742909586754846 -1.22891527233864 0.0475460185287537 mirMAP -0.509841824998332 0.034422024082098 NA NA NA hsa-miR-3065-3p PAX5 2.16221780121195 9.65525739884541e-09 -1.22891527233864 0.0475460185287537 mirMAP -0.172871700559817 0.0275087675675793 NA NA NA hsa-miR-3065-5p PAX5 2.74629919868982 1.86846589298284e-08 -1.22891527233864 0.0475460185287537 mirMAP -0.253519372640291 0.000605739299220647 NA NA NA hsa-miR-30b-3p PAX5 0.834142820354026 0.000972582820878813 -1.22891527233864 0.0475460185287537 mirMAP -0.382162201594424 0.00134685453488451 NA NA NA hsa-miR-3200-3p PAX5 2.70510522077868 1.90469509928484e-08 -1.22891527233864 0.0475460185287537 mirMAP -0.186781445339633 0.00414360291862831 NA NA NA hsa-miR-330-3p PAX5 0.876747334239085 0.00073709016089703 -1.22891527233864 0.0475460185287537 mirMAP -0.264052893417139 0.0225343037639403 NA NA NA hsa-miR-331-3p PAX5 2.28379581858927 1.99663919173155e-18 -1.22891527233864 0.0475460185287537 mirMAP -0.484275719200486 1.08030178752847e-05 NA NA NA hsa-miR-33a-5p PAX5 3.79671563098419 1.15966309820345e-18 -1.22891527233864 0.0475460185287537 mirMAP -0.347490141713838 1.42737875065372e-06 NA NA NA hsa-miR-34a-5p PAX5 1.9016323452565 1.43092834643601e-14 -1.22891527233864 0.0475460185287537 mirMAP -0.520882375191672 9.09442565723312e-06 NA NA NA hsa-miR-378a-5p PAX5 0.223456081148306 0.386368843153575 -1.22891527233864 0.0475460185287537 mirMAP -0.392718248393999 0.000779274651478953 NA NA NA hsa-miR-3913-5p PAX5 2.44353493655328 8.95279496632448e-15 -1.22891527233864 0.0475460185287537 mirMAP -0.278792606781076 0.0033569711454618 NA NA NA hsa-miR-421 PAX5 1.17791565395543 6.78526676976629e-06 -1.22891527233864 0.0475460185287537 mirMAP -0.302971788903413 0.00809400490570693 NA NA NA hsa-miR-423-5p PAX5 0.963563145758616 9.86109015204915e-07 -1.22891527233864 0.0475460185287537 mirMAP -0.432445753246653 0.0045242043888158 NA NA NA hsa-miR-424-5p PAX5 1.61930224569578 1.89642549274994e-10 -1.22891527233864 0.0475460185287537 mirMAP -0.353830254525089 0.00228935576583608 NA NA NA hsa-miR-450b-5p PAX5 1.69244418548325 1.68064054148881e-10 -1.22891527233864 0.0475460185287537 mirMAP -0.378159439115483 0.000663067709735746 NA NA NA hsa-miR-452-5p PAX5 1.37180058737183 0.00171494843537772 -1.22891527233864 0.0475460185287537 mirMAP -0.281918905034329 3.30671756503938e-05 NA NA NA hsa-miR-455-5p PAX5 2.2582442061694 1.43472128037398e-13 -1.22891527233864 0.0475460185287537 mirMAP -0.211774145224201 0.0270033822149839 NA NA NA hsa-miR-582-3p PAX5 0.00876844181512659 0.977126166214707 -1.22891527233864 0.0475460185287537 mirMAP -0.335205585536915 0.000654405092716479 NA NA NA hsa-miR-592 PAX5 1.51765968871077 0.000636335248013204 -1.22891527233864 0.0475460185287537 mirMAP -0.274051533248498 5.81322078429059e-05 NA NA NA hsa-miR-92a-1-5p PAX5 2.23721820014467 5.12925824784972e-09 -1.22891527233864 0.0475460185287537 mirMAP -0.249414960931049 0.00411085303949274 NA NA NA hsa-miR-93-5p PAX5 3.03961860136032 1.11672209617395e-24 -1.22891527233864 0.0475460185287537 mirMAP -0.500836440942379 1.20108847839473e-07 NA NA NA hsa-miR-944 PAX5 2.91186649218281 1.31574753528144e-06 -1.22891527233864 0.0475460185287537 mirMAP -0.202167090902637 6.4171918877192e-05 NA NA NA hsa-miR-96-5p PAX5 4.89433085814374 1.92000659886961e-31 -1.22891527233864 0.0475460185287537 TargetScan -0.352139678635053 1.68245306567783e-07 NA NA NA hsa-miR-432-5p PAX8 -0.128200716359323 0.676832757701632 0.900074465369055 0.0688354160580734 mirMAP -0.16040529956138 0.0417351800214242 NA NA NA hsa-miR-140-5p PBRM1 0.844753502512594 3.73722278438606e-05 -0.397460214092907 0.00860947905394799 miRanda -0.12898702231652 0.000294743766518465 NA NA NA hsa-miR-142-5p PBRM1 1.17581605694506 0.0018174701991234 -0.397460214092907 0.00860947905394799 mirMAP -0.110349805024177 6.5847751087223e-09 NA NA NA hsa-miR-155-5p PBRM1 1.20164021433135 0.00086170622431261 -0.397460214092907 0.00860947905394799 miRNAWalker2_validate -0.129215185464306 6.39318242151003e-11 NA NA NA hsa-miR-193a-3p PBRM1 1.60460546928078 2.86169793322984e-07 -0.397460214092907 0.00860947905394799 miRanda -0.101825836604181 9.10983692666239e-06 NA NA NA hsa-miR-199a-5p PBRM1 0.592984035153911 0.0674836634175293 -0.397460214092907 0.00860947905394799 miRanda -0.123857385657152 2.65622060509545e-08 NA NA NA hsa-miR-199b-5p PBRM1 0.218704279044827 0.519493319158441 -0.397460214092907 0.00860947905394799 miRanda -0.125440762678647 3.53505788292505e-09 NA NA NA hsa-miR-21-5p PBRM1 2.73773305747971 1.38864982139576e-43 -0.397460214092907 0.00860947905394799 miRNAWalker2_validate -0.247526067749202 2.9123046075582e-14 NA NA NA hsa-miR-30a-5p PBRM1 -0.878357906436456 0.000509952992366057 -0.397460214092907 0.00860947905394799 miRNAWalker2_validate -0.102121335602224 0.000398654176818146 NA NA NA hsa-miR-455-5p PBRM1 2.2582442061694 1.43472128037398e-13 -0.397460214092907 0.00860947905394799 miRanda -0.159543810524113 2.15437895107457e-12 NA NA NA hsa-miR-30b-3p PDCD1 0.834142820354026 0.000972582820878813 -0.715212105688873 0.183065965214196 mirMAP -0.696056901275586 5.20477000188309e-12 NA NA NA hsa-miR-331-3p PDCD1 2.28379581858927 1.99663919173155e-18 -0.715212105688873 0.183065965214196 mirMAP -0.533379164255989 1.65653032233931e-08 NA NA NA hsa-let-7a-3p PDGFRA 1.42015538786275 7.03375209382654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.548764001510131 6.84820893227166e-09 NA NA NA hsa-let-7b-3p PDGFRA 0.868207752019623 1.30460056774366e-05 -2.37640583073564 1.39737819859365e-09 mirMAP -0.344538450812629 0.000386110125844406 NA NA NA hsa-let-7b-5p PDGFRA 0.604314269683977 0.00140009936153214 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate -0.521190235799922 3.3085772165913e-07 NA NA NA hsa-let-7f-1-3p PDGFRA 1.55054488387679 7.31326775537952e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.255636194946609 0.00187448794686435 NA NA NA hsa-let-7g-3p PDGFRA 3.26398061402445 3.96263126107645e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.513984859053283 2.05725197047486e-19 NA NA NA hsa-miR-106a-5p PDGFRA 2.48882002962836 1.99757727374521e-12 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.371298633316283 8.91032038900892e-13 NA NA NA hsa-miR-106b-5p PDGFRA 2.46782146831112 1.36171495805632e-23 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.735956870099196 1.34297971882591e-25 NA NA NA hsa-miR-125a-3p PDGFRA 1.24490295132072 5.26925231010328e-06 -2.37640583073564 1.39737819859365e-09 miRanda -0.147350764504837 0.0368213926583983 NA NA NA hsa-miR-129-5p PDGFRA -0.524170159980738 0.222582956006346 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP;miRNATAP -0.128621152047043 0.0051316212954247 NA NA NA hsa-miR-130a-3p PDGFRA 2.02021855058359 1.26427102520415e-11 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.233330487651072 0.000224564945662775 NA NA NA hsa-miR-130b-3p PDGFRA 3.5350292994509 1.73934183852569e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.443010230539233 1.9085252314885e-16 NA NA NA hsa-miR-141-3p PDGFRA 5.02396127982626 2.19224509139725e-24 -2.37640583073564 1.39737819859365e-09 MirTarget -0.379513640202387 7.11112956696243e-28 NA NA NA hsa-miR-149-5p PDGFRA 2.94200492826326 4.93436498919036e-14 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.2660799579696 1.94629645007035e-08 NA NA NA hsa-miR-16-1-3p PDGFRA 2.56983217111073 3.02262181237943e-20 -2.37640583073564 1.39737819859365e-09 MirTarget -0.523089278771913 2.57639641644736e-15 NA NA NA hsa-miR-17-5p PDGFRA 3.2710598467455 9.93128340539455e-27 -2.37640583073564 1.39737819859365e-09 MirTarget;TargetScan;miRNATAP -0.553748753585946 1.23397121105114e-22 NA NA NA hsa-miR-181a-5p PDGFRA 2.29556023480783 1.8138457900616e-21 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.163489892359901 0.0334238760202475 NA NA NA hsa-miR-181b-5p PDGFRA 2.49307679431293 3.92829250217627e-20 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.246762118189355 0.000291477558580384 NA NA NA hsa-miR-181c-5p PDGFRA 1.58587920618301 1.57506918816933e-10 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.154510387774745 0.044722673902946 NA NA NA hsa-miR-181d-5p PDGFRA 1.52204912185579 9.2693319057748e-08 -2.37640583073564 1.39737819859365e-09 MirTarget -0.145317773745093 0.0309239355346582 NA NA NA hsa-miR-182-5p PDGFRA 3.53923166221814 5.07781258121574e-21 -2.37640583073564 1.39737819859365e-09 miRNATAP -0.375439590705967 2.48477058044486e-15 NA NA NA hsa-miR-186-5p PDGFRA 1.47445398888668 3.0781726595413e-15 -2.37640583073564 1.39737819859365e-09 MirTarget -0.700421064109499 1.35088148765239e-12 NA NA NA hsa-miR-196a-5p PDGFRA 1.52993069622497 0.00397268663639603 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.124523334352829 0.000586053454058574 NA NA NA hsa-miR-196b-5p PDGFRA 1.71646270856386 4.37735885910369e-09 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.290309745460117 7.22286389037591e-06 NA NA NA hsa-miR-200a-3p PDGFRA 4.59434485520731 6.38952518573476e-18 -2.37640583073564 1.39737819859365e-09 MirTarget -0.30020684009978 2.24739680558458e-19 NA NA NA hsa-miR-20a-5p PDGFRA 3.15577933619191 4.19753346442454e-25 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.536531231590286 6.48676718494673e-21 NA NA NA hsa-miR-20b-5p PDGFRA 2.07706563022469 1.10107236083433e-05 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.200276264854919 5.98530623190359e-07 NA NA NA hsa-miR-2110 PDGFRA 1.16625590651194 6.4784195289885e-05 -2.37640583073564 1.39737819859365e-09 MirTarget -0.367427900079696 1.6178582537556e-07 NA NA NA hsa-miR-224-5p PDGFRA 2.94107125335675 5.72194099515157e-08 -2.37640583073564 1.39737819859365e-09 MirTarget -0.18329230997559 1.26828530884065e-07 NA NA NA hsa-miR-24-3p PDGFRA 0.99989036772428 1.35595013650376e-07 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.445666887182499 1.04888902991557e-05 NA NA NA hsa-miR-26b-5p PDGFRA 0.885393662798425 3.2116297961629e-06 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.434540118830339 1.79640152621153e-05 NA NA NA hsa-miR-27a-3p PDGFRA 1.66542180327138 4.93775737894805e-13 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.231732831890339 0.00480656820974615 NA NA NA hsa-miR-29b-2-5p PDGFRA 0.910668640983475 0.00666655585493488 -2.37640583073564 1.39737819859365e-09 mirMAP -0.249967909040798 1.27931881284481e-05 NA NA NA hsa-miR-29b-3p PDGFRA 1.65828197923813 1.02676780888141e-09 -2.37640583073564 1.39737819859365e-09 MirTarget -0.200668467003426 0.00420946019654394 NA NA NA hsa-miR-301a-3p PDGFRA 2.81024345929638 2.29784847962242e-17 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.508684565933966 4.36558822645561e-19 NA NA NA hsa-miR-3065-5p PDGFRA 2.74629919868982 1.86846589298284e-08 -2.37640583073564 1.39737819859365e-09 mirMAP -0.166254695248905 0.00048554613178076 NA NA NA hsa-miR-320a PDGFRA 0.438165828017084 0.0390159073347133 -2.37640583073564 1.39737819859365e-09 miRanda -0.402889384468968 1.02856691876917e-05 NA NA NA hsa-miR-320b PDGFRA 1.55692969039548 1.41071034251915e-08 -2.37640583073564 1.39737819859365e-09 miRanda -0.519602099473307 1.42131525257444e-14 NA NA NA hsa-miR-330-5p PDGFRA 1.15100069700871 4.85551805046014e-07 -2.37640583073564 1.39737819859365e-09 miRanda -0.45163495328704 5.41294182541652e-08 NA NA NA hsa-miR-335-3p PDGFRA 3.08791651139852 5.31309869723517e-12 -2.37640583073564 1.39737819859365e-09 mirMAP -0.14687583518123 0.000466962608053098 NA NA NA hsa-miR-339-5p PDGFRA 2.68710938429893 3.03134080808154e-16 -2.37640583073564 1.39737819859365e-09 miRanda -0.338543405646925 1.34989847950552e-09 NA NA NA hsa-miR-33a-5p PDGFRA 3.79671563098419 1.15966309820345e-18 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.396871470489045 1.19728989197256e-18 NA NA NA hsa-miR-34a-5p PDGFRA 1.9016323452565 1.43092834643601e-14 -2.37640583073564 1.39737819859365e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.295453243484317 9.87541559838975e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA 2.07190852984647 7.35776320806257e-08 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.225762830573297 1.74081263395182e-05 NA NA NA hsa-miR-362-3p PDGFRA 2.0756816987665 3.89026064579331e-12 -2.37640583073564 1.39737819859365e-09 miRanda -0.2120805244561 0.00115047466173652 NA NA NA hsa-miR-374a-5p PDGFRA 0.484615721953736 0.0042981729815149 -2.37640583073564 1.39737819859365e-09 mirMAP -0.336442959314977 0.00360859152849973 NA NA NA hsa-miR-421 PDGFRA 1.17791565395543 6.78526676976629e-06 -2.37640583073564 1.39737819859365e-09 PITA;miRanda;miRNATAP -0.474589953500027 4.96575533912116e-11 NA NA NA hsa-miR-429 PDGFRA 4.48815175680773 2.44117492218206e-17 -2.37640583073564 1.39737819859365e-09 miRanda;miRNATAP -0.283783064999005 4.47719067465487e-17 NA NA NA hsa-miR-450b-5p PDGFRA 1.69244418548325 1.68064054148881e-10 -2.37640583073564 1.39737819859365e-09 mirMAP -0.147998086766377 0.0396354356204566 NA NA NA hsa-miR-454-3p PDGFRA 2.47234127820054 1.12878018736016e-21 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.54069398402006 3.51649522550592e-14 NA NA NA hsa-miR-491-5p PDGFRA 0.615770352820862 0.0418295628761654 -2.37640583073564 1.39737819859365e-09 MirTarget;PITA;miRanda;miRNATAP -0.259675783066868 0.000149579704439114 NA NA NA hsa-miR-550a-5p PDGFRA 2.11025227932763 6.94489556637146e-12 -2.37640583073564 1.39737819859365e-09 MirTarget -0.450686953718593 5.51129161245862e-14 NA NA NA hsa-miR-576-5p PDGFRA 2.20467023993664 3.4053475193793e-19 -2.37640583073564 1.39737819859365e-09 mirMAP -0.494558915423906 2.30135204635613e-11 NA NA NA hsa-miR-589-3p PDGFRA 2.51971841868825 2.39125940264107e-11 -2.37640583073564 1.39737819859365e-09 mirMAP -0.375875993689772 1.70404670310081e-11 NA NA NA hsa-miR-590-3p PDGFRA 2.59289455139753 1.03200520972022e-21 -2.37640583073564 1.39737819859365e-09 miRanda;mirMAP -0.493181031896196 4.96463414718196e-13 NA NA NA hsa-miR-590-5p PDGFRA 3.18300989862077 2.06813568597893e-26 -2.37640583073564 1.39737819859365e-09 miRanda -0.507406338027508 3.77905121698734e-17 NA NA NA hsa-miR-664a-3p PDGFRA 0.634721925861133 0.00520070178640421 -2.37640583073564 1.39737819859365e-09 mirMAP -0.190814931098414 0.0260959619653899 NA NA NA hsa-miR-7-1-3p PDGFRA 1.84950311431067 1.25300363397654e-13 -2.37640583073564 1.39737819859365e-09 mirMAP -0.533746456815578 4.42305082401204e-13 NA NA NA hsa-miR-93-5p PDGFRA 3.03961860136032 1.11672209617395e-24 -2.37640583073564 1.39737819859365e-09 MirTarget;miRNATAP -0.564676380038124 7.42892698232966e-22 NA NA NA hsa-miR-944 PDGFRA 2.91186649218281 1.31574753528144e-06 -2.37640583073564 1.39737819859365e-09 mirMAP -0.271450894098107 7.2626459248576e-18 NA NA NA hsa-miR-96-5p PDGFRA 4.89433085814374 1.92000659886961e-31 -2.37640583073564 1.39737819859365e-09 TargetScan;miRNATAP -0.372021838983214 1.0707043407444e-18 NA NA NA hsa-miR-224-5p PDGFRB 2.94107125335675 5.72194099515157e-08 -1.03522303801072 0.00301738788961229 miRNAWalker2_validate -0.147943334000896 1.16237114575095e-06 NA NA NA hsa-miR-24-3p PDGFRB 0.99989036772428 1.35595013650376e-07 -1.03522303801072 0.00301738788961229 MirTarget -0.297654000867495 0.000814454894038923 NA NA NA hsa-miR-28-5p PDGFRB 0.230152919654905 0.0742909586754846 -1.03522303801072 0.00301738788961229 miRanda -0.303906959694572 0.0253692848961482 NA NA NA hsa-miR-29b-3p PDGFRB 1.65828197923813 1.02676780888141e-09 -1.03522303801072 0.00301738788961229 miRNATAP -0.292671948645054 1.48415268440158e-06 NA NA NA hsa-miR-29c-3p PDGFRB -0.00968972577705429 0.97099586346872 -1.03522303801072 0.00301738788961229 miRNATAP -0.359274369001045 1.19150158465265e-08 NA NA NA hsa-miR-3127-5p PDGFRB 1.51846438737133 3.59571251672767e-07 -1.03522303801072 0.00301738788961229 mirMAP -0.437942367228042 7.35571780732733e-16 NA NA NA hsa-miR-34a-5p PDGFRB 1.9016323452565 1.43092834643601e-14 -1.03522303801072 0.00301738788961229 MirTarget -0.3682858109356 2.13745951637981e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 1.07367425434318 1.73142774168958e-09 -1.03522303801072 0.00301738788961229 MirTarget -0.272631369423021 0.00390272618180474 NA NA NA hsa-miR-421 PDGFRB 1.17791565395543 6.78526676976629e-06 -1.03522303801072 0.00301738788961229 miRanda -0.344304119846965 6.47537980961128e-08 NA NA NA hsa-miR-484 PDGFRB 1.81844463411787 1.82951571230938e-15 -1.03522303801072 0.00301738788961229 mirMAP -0.430712318832622 1.16944218559625e-09 NA NA NA hsa-miR-486-5p PDGFRB -0.194913133034028 0.607377798807705 -1.03522303801072 0.00301738788961229 miRanda -0.172192912820644 0.000110418260727812 NA NA NA hsa-miR-491-5p PDGFRB 0.615770352820862 0.0418295628761654 -1.03522303801072 0.00301738788961229 miRanda -0.236736729792446 7.68579463655803e-05 NA NA NA hsa-miR-664a-3p PDGFRB 0.634721925861133 0.00520070178640421 -1.03522303801072 0.00301738788961229 MirTarget -0.524307398841617 6.92902562319671e-13 NA NA NA hsa-miR-9-5p PDGFRB 1.02304182473283 0.042901377604859 -1.03522303801072 0.00301738788961229 MirTarget;miRNATAP -0.128055325842353 0.000120423195513495 NA NA NA hsa-miR-186-5p PDPK1 1.47445398888668 3.0781726595413e-15 -0.446682027133002 0.00835125010618968 mirMAP -0.125708876159213 0.00333632806915964 NA NA NA hsa-miR-22-5p PDPK1 1.88011544159252 1.63978222572222e-16 -0.446682027133002 0.00835125010618968 miRNATAP -0.181020438712566 1.45237356289081e-07 NA NA NA hsa-miR-29b-3p PDPK1 1.65828197923813 1.02676780888141e-09 -0.446682027133002 0.00835125010618968 mirMAP -0.109518325633884 0.000211964623360266 NA NA NA hsa-miR-342-3p PDPK1 1.49115144672245 1.43879249744621e-07 -0.446682027133002 0.00835125010618968 mirMAP -0.109793629457974 0.000113758361154384 NA NA NA hsa-miR-374a-3p PDPK1 0.533309330504947 0.00192918429705142 -0.446682027133002 0.00835125010618968 mirMAP -0.118308754113252 0.0142261349514195 NA NA NA hsa-miR-28-5p PIK3C2G 0.230152919654905 0.0742909586754846 -0.793961306261841 0.1977693293657 miRanda -0.811772401179424 0.000656557570375379 NA NA NA hsa-miR-326 PIK3C2G 0.715313016136042 0.0610265683213359 -0.793961306261841 0.1977693293657 miRanda -0.185987614737315 0.0178452686412739 NA NA NA hsa-miR-429 PIK3C2G 4.48815175680773 2.44117492218206e-17 -0.793961306261841 0.1977693293657 miRanda;miRNATAP -0.165438098109069 0.00214644206323715 NA NA NA hsa-miR-532-5p PIK3C2G 1.55697650978597 1.57884735535196e-11 -0.793961306261841 0.1977693293657 MirTarget -0.277555275665333 0.0288013802384021 NA NA NA hsa-miR-98-5p PIK3C3 1.11154309866014 1.24143909012085e-08 -0.182585325506977 0.15830552662018 miRNAWalker2_validate -0.119789584179927 0.000148935496597243 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-146b-3p PIM1 1.10569195233795 0.000660632782194023 -0.892248221728615 0.000729042000085614 PITA;miRNATAP -0.12999446328182 0.000940503743011654 NA NA NA hsa-miR-16-5p PIM1 1.75824877145857 1.68592440033108e-16 -0.892248221728615 0.000729042000085614 miRNAWalker2_validate;miRTarBase;miRNATAP -0.123802234803259 0.0343880510410189 NA NA NA hsa-miR-339-5p PIM1 2.68710938429893 3.03134080808154e-16 -0.892248221728615 0.000729042000085614 miRanda -0.134813187944166 0.000328465721310194 NA NA NA hsa-miR-629-3p PIM1 2.36570947321815 1.33458201201618e-11 -0.892248221728615 0.000729042000085614 miRNATAP -0.112864350317053 0.00535785200387196 NA NA NA hsa-miR-128-3p PLK2 1.63756041666078 6.79626586407187e-14 -0.184734083567005 0.553818611811747 MirTarget -0.354383413181056 1.0046066373698e-07 NA NA NA hsa-miR-200b-3p PLK2 3.78235093249346 3.18343003239465e-14 -0.184734083567005 0.553818611811747 TargetScan -0.200777308467135 1.9672804111015e-12 NA NA NA hsa-miR-200c-3p PLK2 3.50132673580082 2.42716349086937e-15 -0.184734083567005 0.553818611811747 miRNATAP -0.153685938478197 2.41030637915006e-06 NA NA NA hsa-miR-320a PLK2 0.438165828017084 0.0390159073347133 -0.184734083567005 0.553818611811747 PITA;miRanda;miRNATAP -0.184313720470446 0.0100564201981922 NA NA NA hsa-miR-320b PLK2 1.55692969039548 1.41071034251915e-08 -0.184734083567005 0.553818611811747 PITA;miRanda;miRNATAP -0.107032028437745 0.0486096444085637 NA NA NA hsa-miR-421 PLK2 1.17791565395543 6.78526676976629e-06 -0.184734083567005 0.553818611811747 MirTarget;PITA;miRanda;miRNATAP -0.195105312340364 0.000653263579224093 NA NA NA hsa-miR-429 PLK2 4.48815175680773 2.44117492218206e-17 -0.184734083567005 0.553818611811747 PITA;miRanda;miRNATAP -0.183900095885113 5.08035668249416e-12 NA NA NA hsa-miR-501-3p PLK2 1.83132758513743 1.10971547702065e-10 -0.184734083567005 0.553818611811747 PITA;miRNATAP -0.138036111301816 0.00802654375749319 NA NA NA hsa-miR-505-3p PLK2 1.45322244209148 8.86597629645867e-10 -0.184734083567005 0.553818611811747 MirTarget;miRNATAP -0.141140595179948 0.0245004782130108 NA NA NA hsa-miR-98-5p PLK2 1.11154309866014 1.24143909012085e-08 -0.184734083567005 0.553818611811747 miRNAWalker2_validate -0.503022309819797 2.05446947447367e-11 NA NA NA hsa-let-7a-3p PNRC1 1.42015538786275 7.03375209382654e-13 -1.19214185444935 3.43127246857321e-11 miRNATAP -0.195411183889495 8.37344255284606e-06 NA NA NA hsa-miR-101-3p PNRC1 0.522819989585461 0.00375627731618038 -1.19214185444935 3.43127246857321e-11 miRNATAP -0.103106143451641 0.0390161892062396 NA NA NA hsa-miR-126-5p PNRC1 0.895338176458417 2.33372756450713e-05 -1.19214185444935 3.43127246857321e-11 MirTarget;miRNATAP -0.210484439327654 4.19686858894582e-07 NA NA NA hsa-miR-16-1-3p PNRC1 2.56983217111073 3.02262181237943e-20 -1.19214185444935 3.43127246857321e-11 MirTarget -0.146996772359195 2.28785048203984e-06 NA NA NA hsa-miR-19a-3p PNRC1 3.42309334186656 3.02671914353412e-28 -1.19214185444935 3.43127246857321e-11 MirTarget;miRNATAP -0.173599346698786 3.7068226886084e-11 NA NA NA hsa-miR-19b-3p PNRC1 2.49529833021187 1.57028265846699e-23 -1.19214185444935 3.43127246857321e-11 MirTarget;miRNATAP -0.20267658203534 1.13390760594166e-09 NA NA NA hsa-miR-23b-3p PNRC1 -0.251132426825047 0.150200321210792 -1.19214185444935 3.43127246857321e-11 MirTarget -0.109443842629542 0.0349435236997843 NA NA NA hsa-miR-26b-5p PNRC1 0.885393662798425 3.2116297961629e-06 -1.19214185444935 3.43127246857321e-11 MirTarget;miRNATAP -0.123858213260051 0.0082163065891276 NA NA NA hsa-miR-32-3p PNRC1 2.02436999565685 5.94091197945307e-09 -1.19214185444935 3.43127246857321e-11 MirTarget;miRNATAP -0.141165804201079 6.67902269955329e-07 NA NA NA hsa-miR-320a PNRC1 0.438165828017084 0.0390159073347133 -1.19214185444935 3.43127246857321e-11 miRanda -0.115216230751683 0.00640287346231374 NA NA NA hsa-miR-320b PNRC1 1.55692969039548 1.41071034251915e-08 -1.19214185444935 3.43127246857321e-11 miRanda -0.13611745059658 1.83521055775324e-05 NA NA NA hsa-miR-335-5p PNRC1 1.77247705492746 2.22457658872091e-06 -1.19214185444935 3.43127246857321e-11 miRNAWalker2_validate -0.16488419786565 5.72787604924574e-13 NA NA NA hsa-miR-374a-5p PNRC1 0.484615721953736 0.0042981729815149 -1.19214185444935 3.43127246857321e-11 MirTarget -0.258271375190453 9.18821587703552e-07 NA NA NA hsa-miR-423-5p PNRC1 0.963563145758616 9.86109015204915e-07 -1.19214185444935 3.43127246857321e-11 miRNAWalker2_validate -0.232776785555227 1.80888860795204e-07 NA NA NA hsa-miR-429 PNRC1 4.48815175680773 2.44117492218206e-17 -1.19214185444935 3.43127246857321e-11 miRNATAP -0.153171320446879 1.00407894868566e-23 NA NA NA hsa-miR-450b-5p PNRC1 1.69244418548325 1.68064054148881e-10 -1.19214185444935 3.43127246857321e-11 MirTarget -0.184596699224506 1.35409693501958e-08 NA NA NA hsa-miR-484 PNRC1 1.81844463411787 1.82951571230938e-15 -1.19214185444935 3.43127246857321e-11 MirTarget -0.225676633015358 1.27410273567519e-09 NA NA NA hsa-miR-590-3p PNRC1 2.59289455139753 1.03200520972022e-21 -1.19214185444935 3.43127246857321e-11 miRanda -0.169436554827363 9.85589504590183e-08 NA NA NA hsa-miR-98-5p PNRC1 1.11154309866014 1.24143909012085e-08 -1.19214185444935 3.43127246857321e-11 miRNAWalker2_validate -0.37421993818474 8.93188170082542e-18 NA NA NA hsa-let-7e-5p PRDM1 0.860104282510173 6.04758298373779e-05 -0.799773282697487 0.0106840144209139 miRNATAP -0.280559891603728 6.95599054488471e-05 NA NA NA hsa-let-7f-5p PRDM1 0.495648727272215 0.00355972741198794 -0.799773282697487 0.0106840144209139 miRNAWalker2_validate;miRTarBase;miRNATAP -0.22376889291765 0.013479719326758 NA NA NA hsa-let-7g-5p PRDM1 1.20061455355116 1.50237505511483e-12 -0.799773282697487 0.0106840144209139 miRNATAP -0.402614377689233 4.45400232889189e-06 NA NA NA hsa-miR-125a-5p PRDM1 0.599529391575274 0.0102300147180307 -0.799773282697487 0.0106840144209139 PITA;miRanda -0.341052327510132 1.27134111994176e-07 NA NA NA hsa-miR-182-5p PRDM1 3.53923166221814 5.07781258121574e-21 -0.799773282697487 0.0106840144209139 miRNATAP -0.149673383161081 9.06896532328256e-05 NA NA NA hsa-miR-186-5p PRDM1 1.47445398888668 3.0781726595413e-15 -0.799773282697487 0.0106840144209139 mirMAP;miRNATAP -0.27487985092907 0.000521349166623336 NA NA NA hsa-miR-19a-3p PRDM1 3.42309334186656 3.02671914353412e-28 -0.799773282697487 0.0106840144209139 miRNATAP -0.164667128475003 0.000305151455336821 NA NA NA hsa-miR-19b-3p PRDM1 2.49529833021187 1.57028265846699e-23 -0.799773282697487 0.0106840144209139 miRNATAP -0.224951956169733 9.2466611786557e-05 NA NA NA hsa-miR-200b-3p PRDM1 3.78235093249346 3.18343003239465e-14 -0.799773282697487 0.0106840144209139 TargetScan -0.15934460990506 4.27155875855763e-08 NA NA NA hsa-miR-200c-3p PRDM1 3.50132673580082 2.42716349086937e-15 -0.799773282697487 0.0106840144209139 miRNATAP -0.101768221707449 0.00210189024339143 NA NA NA hsa-miR-30c-5p PRDM1 0.778774633108 0.000285599212429136 -0.799773282697487 0.0106840144209139 miRNATAP -0.384767552197635 3.84698413865702e-08 NA NA NA hsa-miR-30d-5p PRDM1 0.675423997639582 0.00270618816039773 -0.799773282697487 0.0106840144209139 miRNATAP -0.466134922592372 1.68081623165114e-12 NA NA NA hsa-miR-32-3p PRDM1 2.02436999565685 5.94091197945307e-09 -0.799773282697487 0.0106840144209139 miRNATAP -0.227751764657536 2.71806755379081e-06 NA NA NA hsa-miR-335-3p PRDM1 3.08791651139852 5.31309869723517e-12 -0.799773282697487 0.0106840144209139 mirMAP -0.134344542233084 4.26564929552454e-05 NA NA NA hsa-miR-33a-3p PRDM1 1.72765312072219 1.51784443453521e-07 -0.799773282697487 0.0106840144209139 mirMAP -0.182610674859034 0.000254161499980488 NA NA NA hsa-miR-361-5p PRDM1 0.971859117235239 5.30236555707088e-09 -0.799773282697487 0.0106840144209139 miRanda -0.467584423124133 2.07661925917774e-07 NA NA NA hsa-miR-429 PRDM1 4.48815175680773 2.44117492218206e-17 -0.799773282697487 0.0106840144209139 PITA;miRanda;miRNATAP -0.157081260806255 6.4760394375184e-09 NA NA NA hsa-miR-450b-5p PRDM1 1.69244418548325 1.68064054148881e-10 -0.799773282697487 0.0106840144209139 PITA;mirMAP;miRNATAP -0.14323531275398 0.0109913010145031 NA NA NA hsa-miR-186-5p PRKAR1A 1.47445398888668 3.0781726595413e-15 -0.494707246064478 1.09832496534671e-05 mirMAP -0.158555937704806 1.81385800124173e-08 NA NA NA hsa-miR-25-3p PRKAR1A 1.36472605225697 4.83790725935681e-11 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.130633923717046 3.57662021897474e-07 NA NA NA hsa-miR-30b-5p PRKAR1A 0.800822374912712 0.000133601914525413 -0.494707246064478 1.09832496534671e-05 mirMAP -0.109738357042516 2.35678449980593e-05 NA NA NA hsa-miR-30c-5p PRKAR1A 0.778774633108 0.000285599212429136 -0.494707246064478 1.09832496534671e-05 mirMAP -0.117852671733036 3.18561702613009e-06 NA NA NA hsa-miR-30e-5p PRKAR1A 1.23904909539663 1.35561917122157e-09 -0.494707246064478 1.09832496534671e-05 mirMAP -0.13563514438677 2.13471830667205e-07 NA NA NA hsa-miR-181a-5p PTPN11 2.29556023480783 1.8138457900616e-21 -0.452433350411265 0.00325956478076793 miRNAWalker2_validate;miRTarBase -0.185487084256816 1.39341679605697e-10 NA NA NA hsa-miR-186-5p PTPN11 1.47445398888668 3.0781726595413e-15 -0.452433350411265 0.00325956478076793 mirMAP -0.143929471124778 0.000206640326809661 NA NA NA hsa-miR-19b-3p PTPN11 2.49529833021187 1.57028265846699e-23 -0.452433350411265 0.00325956478076793 mirMAP -0.133832285409827 1.87038395237857e-06 NA NA NA hsa-miR-30d-3p PTPN11 0.977747550180601 4.3048212205381e-05 -0.452433350411265 0.00325956478076793 mirMAP -0.101814565598371 0.0010416662764693 NA NA NA hsa-miR-660-5p PTPN11 1.82692095272076 1.92040083607196e-13 -0.452433350411265 0.00325956478076793 mirMAP -0.150622441103972 1.85298087787683e-07 NA NA NA hsa-miR-455-5p PTPRS 2.2582442061694 1.43472128037398e-13 -1.18025521618805 0.000838965798319378 PITA;miRanda;miRNATAP -0.235359252211849 1.47507685868289e-05 NA NA NA hsa-miR-590-3p PTPRS 2.59289455139753 1.03200520972022e-21 -1.18025521618805 0.000838965798319378 miRanda -0.174821331882759 0.00490127336930146 NA NA NA hsa-let-7g-3p PTPRT 3.26398061402445 3.96263126107645e-25 -1.14669022358092 0.0603101003106215 miRNATAP -0.291760770422931 0.00130043367148141 NA NA NA hsa-miR-10a-5p PTPRT 1.15016989191194 0.00372037233992369 -1.14669022358092 0.0603101003106215 miRNAWalker2_validate;mirMAP -0.208412034237178 0.00500431487784839 NA NA NA hsa-miR-10b-3p PTPRT 0.77597971642517 0.00264877454133753 -1.14669022358092 0.0603101003106215 mirMAP -0.420659843500133 0.000229993932402729 NA NA NA hsa-miR-10b-5p PTPRT -0.155951595811628 0.555006386998027 -1.14669022358092 0.0603101003106215 miRNAWalker2_validate;mirMAP -0.223114720417778 0.0478525394715422 NA NA NA hsa-miR-1226-3p PTPRT 1.38118928579963 0.000205503474787488 -1.14669022358092 0.0603101003106215 mirMAP -0.179703870847516 0.0472092695760095 NA NA NA hsa-miR-135b-5p PTPRT 3.62510365056501 1.09148980810091e-10 -1.14669022358092 0.0603101003106215 mirMAP -0.255598768228383 2.18974152901366e-06 NA NA NA hsa-miR-148b-5p PTPRT 2.18024067300781 2.84770452413262e-14 -1.14669022358092 0.0603101003106215 mirMAP -0.283562173815546 0.00744312722786075 NA NA NA hsa-miR-16-2-3p PTPRT 2.31623086727196 4.29838149388188e-20 -1.14669022358092 0.0603101003106215 mirMAP -0.44987749502381 5.64162756910331e-05 NA NA NA hsa-miR-16-5p PTPRT 1.75824877145857 1.68592440033108e-16 -1.14669022358092 0.0603101003106215 miRNAWalker2_validate -0.506636088225822 0.000156177896220001 NA NA NA hsa-miR-17-3p PTPRT 2.2704817679209 1.1667437320211e-22 -1.14669022358092 0.0603101003106215 mirMAP -0.379653124430858 0.00177119073123614 NA NA NA hsa-miR-181b-5p PTPRT 2.49307679431293 3.92829250217627e-20 -1.14669022358092 0.0603101003106215 mirMAP -0.321139683431913 0.00205100220152754 NA NA NA hsa-miR-192-5p PTPRT 2.69002528723195 1.22990188194432e-16 -1.14669022358092 0.0603101003106215 mirMAP -0.183748730346202 0.0364770779196436 NA NA NA hsa-miR-1976 PTPRT 2.06550563678192 7.81396978619772e-18 -1.14669022358092 0.0603101003106215 mirMAP -0.558814969870832 2.07471418413952e-06 NA NA NA hsa-miR-200c-5p PTPRT 2.95761105443819 3.11105707262802e-11 -1.14669022358092 0.0603101003106215 mirMAP -0.204834130499205 0.00293292098210035 NA NA NA hsa-miR-20a-5p PTPRT 3.15577933619191 4.19753346442454e-25 -1.14669022358092 0.0603101003106215 miRNATAP -0.310320238694123 0.000671465636238412 NA NA NA hsa-miR-21-5p PTPRT 2.73773305747971 1.38864982139576e-43 -1.14669022358092 0.0603101003106215 mirMAP -0.288191464679835 0.0337799384835906 NA NA NA hsa-miR-222-5p PTPRT 1.25632771414778 0.000138653440511922 -1.14669022358092 0.0603101003106215 mirMAP -0.256405432389047 0.00400706966006994 NA NA NA hsa-miR-224-3p PTPRT 1.87536386559317 6.15140969394846e-05 -1.14669022358092 0.0603101003106215 mirMAP -0.337356356156352 1.94333499875888e-07 NA NA NA hsa-miR-23a-3p PTPRT 1.00493340843378 2.55313889288924e-08 -1.14669022358092 0.0603101003106215 mirMAP -1.06029731276772 3.34456630640777e-11 NA NA NA hsa-miR-24-2-5p PTPRT 2.07171035460647 3.15853539996136e-16 -1.14669022358092 0.0603101003106215 mirMAP -0.485188919155005 1.49305902506822e-05 NA NA NA hsa-miR-26b-5p PTPRT 0.885393662798425 3.2116297961629e-06 -1.14669022358092 0.0603101003106215 mirMAP -0.460557474522361 0.00305982389439751 NA NA NA hsa-miR-27a-3p PTPRT 1.66542180327138 4.93775737894805e-13 -1.14669022358092 0.0603101003106215 mirMAP;miRNATAP -0.650859797068203 1.52354788258613e-07 NA NA NA hsa-miR-29a-5p PTPRT 1.46749674755271 3.34605004270294e-07 -1.14669022358092 0.0603101003106215 mirMAP -0.415996121622204 0.00010261569751217 NA NA NA hsa-miR-330-3p PTPRT 0.876747334239085 0.00073709016089703 -1.14669022358092 0.0603101003106215 mirMAP -0.243018985367376 0.0329309889207062 NA NA NA hsa-miR-330-5p PTPRT 1.15100069700871 4.85551805046014e-07 -1.14669022358092 0.0603101003106215 mirMAP -0.405470769626364 0.00156711344320999 NA NA NA hsa-miR-331-3p PTPRT 2.28379581858927 1.99663919173155e-18 -1.14669022358092 0.0603101003106215 miRNAWalker2_validate;mirMAP -0.43497326376939 6.09481719724463e-05 NA NA NA hsa-miR-33a-3p PTPRT 1.72765312072219 1.51784443453521e-07 -1.14669022358092 0.0603101003106215 mirMAP -0.193734591429299 0.047386450920844 NA NA NA hsa-miR-3607-3p PTPRT 2.68532138541128 5.66716351955047e-14 -1.14669022358092 0.0603101003106215 mirMAP -0.18843094828591 0.0224293700985414 NA NA NA hsa-miR-452-3p PTPRT 2.42521958420768 4.08754552781156e-07 -1.14669022358092 0.0603101003106215 mirMAP -0.293102453874717 1.28419028579318e-06 NA NA NA hsa-miR-550a-3p PTPRT 1.78308792532884 2.47673569057582e-07 -1.14669022358092 0.0603101003106215 mirMAP -0.27142371697524 0.00459050709082893 NA NA NA hsa-miR-576-5p PTPRT 2.20467023993664 3.4053475193793e-19 -1.14669022358092 0.0603101003106215 mirMAP -0.297801238668367 0.00989144260391966 NA NA NA hsa-miR-584-5p PTPRT 2.7326672683732 9.92677936962233e-12 -1.14669022358092 0.0603101003106215 mirMAP -0.28244487201873 7.63926179782899e-05 NA NA NA hsa-miR-590-5p PTPRT 3.18300989862077 2.06813568597893e-26 -1.14669022358092 0.0603101003106215 mirMAP -0.189858274422458 0.0471338686261405 NA NA NA hsa-miR-7-1-3p PTPRT 1.84950311431067 1.25300363397654e-13 -1.14669022358092 0.0603101003106215 mirMAP -0.233307454403577 0.043778470887324 NA NA NA hsa-miR-744-3p PTPRT 2.7517405670917 4.22040908411227e-14 -1.14669022358092 0.0603101003106215 mirMAP -0.282660536327463 0.000310797094067384 NA NA NA hsa-miR-92a-3p PTPRT 2.06460102658973 1.44784291084757e-19 -1.14669022358092 0.0603101003106215 mirMAP -0.462546700831644 0.000193659915907962 NA NA NA hsa-miR-374b-5p RAC1 0.0654362503857184 0.722673188879465 0.221936454340431 0.051549220692643 mirMAP -0.101573831955509 0.000746852128506454 NA NA NA hsa-miR-22-5p RAD50 1.88011544159252 1.63978222572222e-16 -0.240272166330794 0.109938417263535 mirMAP -0.120527296085371 8.49104487394344e-05 NA NA NA hsa-miR-23b-3p RAD51 -0.251132426825047 0.150200321210792 2.85322569573673 5.03537784086548e-31 miRNAWalker2_validate -0.179558810695395 0.0164434548206517 NA NA NA hsa-miR-320a RAD51C 0.438165828017084 0.0390159073347133 0.243890393986967 0.0858555217987683 miRanda -0.113763385465262 0.000448248899684788 NA NA NA hsa-miR-766-3p RAD52 1.2456012547833 6.44584025471128e-06 0.276585016132251 0.10671353899104 MirTarget -0.110502442937903 0.000194159507838305 NA NA NA hsa-miR-30c-5p RASA1 0.778774633108 0.000285599212429136 -0.0207024925540615 0.910533635152395 miRNAWalker2_validate;MirTarget;miRNATAP -0.14388971632777 0.000504818574153645 NA NA NA hsa-miR-30e-5p RASA1 1.23904909539663 1.35561917122157e-09 -0.0207024925540615 0.910533635152395 MirTarget -0.106221938279274 0.0135916128967349 NA NA NA hsa-miR-320a RASA1 0.438165828017084 0.0390159073347133 -0.0207024925540615 0.910533635152395 MirTarget;PITA;miRanda;miRNATAP -0.156593432428182 0.000194139100509342 NA NA NA hsa-miR-217 REL 0.608024397387488 0.199352491710517 -0.37107090294153 0.295384901319937 miRanda -0.162147881881152 1.12733153320328e-05 NA NA NA hsa-miR-103a-3p RET 1.44083190496858 1.53799939616416e-13 -0.845706703693476 0.0349656102167993 MirTarget -0.427309853784285 1.04753812531677e-05 NA NA NA hsa-miR-107 RET 1.30977326593435 1.30372468603965e-11 -0.845706703693476 0.0349656102167993 MirTarget;miRanda -0.275148805469127 0.00543724313636909 NA NA NA hsa-miR-125a-5p RET 0.599529391575274 0.0102300147180307 -0.845706703693476 0.0349656102167993 PITA;miRanda -0.244102442748386 0.00346934818702249 NA NA NA hsa-miR-128-3p RET 1.63756041666078 6.79626586407187e-14 -0.845706703693476 0.0349656102167993 MirTarget -0.208504350898089 0.0164382640592658 NA NA NA hsa-miR-15a-5p RET 2.34669284378787 1.69544424500258e-23 -0.845706703693476 0.0349656102167993 MirTarget;miRNATAP -0.336962866415739 1.61398188907349e-05 NA NA NA hsa-miR-15b-5p RET 1.57112623124278 9.14247846750597e-13 -0.845706703693476 0.0349656102167993 MirTarget;miRNATAP -0.365201456845804 2.16502447654426e-05 NA NA NA hsa-miR-16-5p RET 1.75824877145857 1.68592440033108e-16 -0.845706703693476 0.0349656102167993 MirTarget;miRNATAP -0.284509759120613 0.00126563064949263 NA NA NA hsa-miR-192-5p RET 2.69002528723195 1.22990188194432e-16 -0.845706703693476 0.0349656102167993 miRNAWalker2_validate -0.191078016900396 0.000891056292644353 NA NA NA hsa-miR-196b-5p RET 1.71646270856386 4.37735885910369e-09 -0.845706703693476 0.0349656102167993 MirTarget -0.176255808251384 0.00702133485437688 NA NA NA hsa-miR-20a-3p RET 2.92621109947706 2.49504904635375e-17 -0.845706703693476 0.0349656102167993 MirTarget -0.175480342526336 0.0015532629998514 NA NA NA hsa-miR-320b RET 1.55692969039548 1.41071034251915e-08 -0.845706703693476 0.0349656102167993 mirMAP -0.151460479524108 0.0302999445482597 NA NA NA hsa-miR-33a-3p RET 1.72765312072219 1.51784443453521e-07 -0.845706703693476 0.0349656102167993 mirMAP -0.207832732353721 0.00115555896465443 NA NA NA hsa-miR-34a-5p RET 1.9016323452565 1.43092834643601e-14 -0.845706703693476 0.0349656102167993 MirTarget -0.280340222615168 0.000232922767956132 NA NA NA hsa-miR-361-5p RET 0.971859117235239 5.30236555707088e-09 -0.845706703693476 0.0349656102167993 miRanda -0.45731122899883 8.01745689945841e-05 NA NA NA hsa-miR-484 RET 1.81844463411787 1.82951571230938e-15 -0.845706703693476 0.0349656102167993 PITA -0.219874983013034 0.00775867149791081 NA NA NA hsa-miR-501-5p RET 1.93654809410041 1.3779381780759e-10 -0.845706703693476 0.0349656102167993 PITA;miRNATAP -0.202967204522265 0.00176425426797235 NA NA NA hsa-miR-590-5p RET 3.18300989862077 2.06813568597893e-26 -0.845706703693476 0.0349656102167993 miRanda -0.224120629015546 0.000337386801231457 NA NA NA hsa-miR-361-5p RHOA 0.971859117235239 5.30236555707088e-09 -0.230748867704724 0.030592243709878 MirTarget;PITA;miRanda -0.164727125115389 5.91440692337907e-08 NA NA NA hsa-let-7i-5p RICTOR 0.412877696970403 0.00622731051981756 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.181498389332032 0.000474512978277903 NA NA NA hsa-miR-139-5p RICTOR -1.52606598644743 1.20474151350665e-08 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRanda -0.117309140283128 3.26793845059091e-05 NA NA NA hsa-miR-140-3p RICTOR 0.0608890720479334 0.727716871248724 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRNATAP -0.139944872162773 0.00177546724259963 NA NA NA hsa-miR-218-5p RICTOR -0.573801507392184 0.0551983860126703 -0.0636558558251128 0.690801456304219 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128099349308607 5.27766413859692e-07 NA NA NA hsa-miR-495-3p RICTOR -0.0847115949846082 0.763475496144456 -0.0636558558251128 0.690801456304219 MirTarget -0.143309782555465 1.46249599436837e-07 NA NA NA hsa-miR-497-5p RICTOR 0.0257087130056286 0.918145413833358 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.107838893771902 0.000492230040753755 NA NA NA hsa-miR-660-5p RICTOR 1.82692095272076 1.92040083607196e-13 -0.0636558558251128 0.690801456304219 MirTarget -0.125254027693193 3.16011915894253e-05 NA NA NA hsa-miR-132-3p RIT1 0.156276992635384 0.408190812100704 0.0167812650158075 0.907279375232571 MirTarget -0.135688124685375 0.000252810190148032 NA NA NA hsa-miR-29a-3p RIT1 -0.35074463683376 0.161238718982428 0.0167812650158075 0.907279375232571 MirTarget -0.12654918164889 4.6623856027737e-06 NA NA NA hsa-miR-25-3p RPS6KA4 1.36472605225697 4.83790725935681e-11 0.691826748311756 7.91091742889804e-05 MirTarget -0.145771432406332 0.000304038062710177 NA NA NA hsa-miR-363-3p RPS6KA4 1.50575300026701 0.00020976164678918 0.691826748311756 7.91091742889804e-05 MirTarget -0.119696919430121 5.65615975795963e-09 NA NA NA hsa-miR-423-5p RPS6KA4 0.963563145758616 9.86109015204915e-07 0.691826748311756 7.91091742889804e-05 MirTarget -0.122065107603161 0.00474772215273447 NA NA NA hsa-miR-148a-3p RPTOR 1.26728238710376 2.52325607402829e-06 -0.479637741652061 5.89716317949949e-06 mirMAP -0.106505166600003 1.15705839238367e-08 NA NA NA hsa-miR-361-3p RPTOR 1.07367425434318 1.73142774168958e-09 -0.479637741652061 5.89716317949949e-06 MirTarget -0.136451834190925 1.55302428680942e-06 NA NA NA hsa-miR-139-5p RUNX1 -1.52606598644743 1.20474151350665e-08 0.65040732907846 0.000423063308787084 PITA;miRanda -0.114228533542765 0.000521699197057377 NA NA NA hsa-miR-23a-3p RYBP 1.00493340843378 2.55313889288924e-08 -0.452688009480886 0.00132219893291539 MirTarget -0.146087945121979 0.00010011221253547 NA NA NA hsa-miR-24-2-5p RYBP 2.07171035460647 3.15853539996136e-16 -0.452688009480886 0.00132219893291539 MirTarget -0.159652214627493 4.26288884474406e-10 NA NA NA hsa-miR-27a-3p RYBP 1.66542180327138 4.93775737894805e-13 -0.452688009480886 0.00132219893291539 MirTarget -0.159639984961846 2.28721337594762e-08 NA NA NA hsa-miR-29a-5p RYBP 1.46749674755271 3.34605004270294e-07 -0.452688009480886 0.00132219893291539 MirTarget -0.186633705297836 9.30152487196694e-15 NA NA NA hsa-miR-140-5p SETD2 0.844753502512594 3.73722278438606e-05 -0.183491510728843 0.132486222465729 miRanda -0.137858524438801 1.2229622030764e-06 NA NA NA hsa-miR-146b-5p SETD2 1.75587235896724 1.15724631266659e-07 -0.183491510728843 0.132486222465729 PITA;miRanda -0.119884732505243 2.02443580659294e-12 NA NA NA hsa-miR-182-5p SH2D1A 3.53923166221814 5.07781258121574e-21 -1.10597424227522 0.0293424555172639 MirTarget;miRNATAP -0.372541578671597 1.10440891703557e-09 NA NA NA hsa-miR-335-3p SH2D1A 3.08791651139852 5.31309869723517e-12 -1.10597424227522 0.0293424555172639 mirMAP -0.282145355240226 9.07125448380878e-08 NA NA NA hsa-miR-361-5p SH2D1A 0.971859117235239 5.30236555707088e-09 -1.10597424227522 0.0293424555172639 miRanda -0.949783964809007 4.86661800063316e-11 NA NA NA hsa-miR-589-3p SH2D1A 2.51971841868825 2.39125940264107e-11 -1.10597424227522 0.0293424555172639 MirTarget -0.200840254641437 0.00560880560638313 NA NA NA hsa-miR-944 SH2D1A 2.91186649218281 1.31574753528144e-06 -1.10597424227522 0.0293424555172639 mirMAP -0.151484733070518 0.000259783426371348 NA NA NA hsa-miR-96-5p SH2D1A 4.89433085814374 1.92000659886961e-31 -1.10597424227522 0.0293424555172639 miRNATAP -0.347544885012022 2.0889260257566e-10 NA NA NA hsa-miR-181a-5p SMAD2 2.29556023480783 1.8138457900616e-21 -0.217872679367038 0.049686680004959 mirMAP -0.112519930018506 7.12492899365623e-08 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 2.49307679431293 3.92829250217627e-20 -0.217872679367038 0.049686680004959 mirMAP -0.102985568847665 2.98550912982442e-08 NA NA NA hsa-miR-26a-5p SMAD2 0.0464832722967259 0.752628386912329 -0.217872679367038 0.049686680004959 mirMAP -0.11130754251612 0.0026935683249941 NA NA NA hsa-miR-361-3p SMAD2 1.07367425434318 1.73142774168958e-09 -0.217872679367038 0.049686680004959 miRNATAP -0.114638945395339 0.000110242156000821 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-let-7a-2-3p SMAD3 0.0400317820791161 0.91528727576685 -0.145068391221315 0.569239559252949 mirMAP -0.127624470471724 0.000115244641159406 NA NA NA hsa-miR-125b-2-3p SMAD3 -1.83175829351767 2.94917958974528e-05 -0.145068391221315 0.569239559252949 mirMAP -0.167358601156691 2.00437048846808e-09 NA NA NA hsa-miR-127-5p SMAD3 1.19850695520181 4.10976607177645e-05 -0.145068391221315 0.569239559252949 mirMAP -0.175774439508378 2.40422906256706e-05 NA NA NA hsa-miR-132-3p SMAD3 0.156276992635384 0.408190812100704 -0.145068391221315 0.569239559252949 mirMAP -0.307625427852275 2.61092084929535e-06 NA NA NA hsa-miR-142-5p SMAD3 1.17581605694506 0.0018174701991234 -0.145068391221315 0.569239559252949 PITA -0.121783193917905 0.000168543842540946 NA NA NA hsa-miR-145-5p SMAD3 -1.55259331973517 9.97889123247165e-07 -0.145068391221315 0.569239559252949 MirTarget;miRNATAP -0.102333497957109 0.0076425159078547 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 1.20164021433135 0.00086170622431261 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.167586664196246 6.20173080978562e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-186-5p SMAD3 1.47445398888668 3.0781726595413e-15 -0.145068391221315 0.569239559252949 mirMAP -0.133188903744895 0.0388863467309017 NA NA NA hsa-miR-188-5p SMAD3 2.52825126596644 6.78099435999778e-14 -0.145068391221315 0.569239559252949 PITA -0.184950370967834 7.35063541952032e-07 NA NA NA hsa-miR-18a-5p SMAD3 3.78535678765353 3.72446596213886e-26 -0.145068391221315 0.569239559252949 miRNAWalker2_validate -0.136878014915373 5.63544047470077e-05 23249750 The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling glioblastoma hsa-miR-195-5p SMAD3 -1.44753678070504 8.70594292149271e-09 -0.145068391221315 0.569239559252949 MirTarget -0.155082880098317 0.00129697117488075 27206216 MiR 195 Suppresses Cervical Cancer Migration and Invasion Through Targeting Smad3; The purposes of this study were to investigate the role of miR-195 in cervical cancer and clarify the regulation of Smad3 by miR-195; Smad3 was verified as a direct target of miR-195 which was further confirmed by the inverse expression of miR-195 and Smad3 in patients' specimens cervical and endocervical cancer hsa-miR-212-3p SMAD3 0.357878936470387 0.232446214501331 -0.145068391221315 0.569239559252949 mirMAP -0.196270501722139 1.760966299711e-06 NA NA NA hsa-miR-326 SMAD3 0.715313016136042 0.0610265683213359 -0.145068391221315 0.569239559252949 miRanda -0.127854658986735 7.18944162313972e-05 NA NA NA hsa-miR-424-5p SMAD3 1.61930224569578 1.89642549274994e-10 -0.145068391221315 0.569239559252949 MirTarget -0.137637867799144 0.0037931514509118 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-485-3p SMAD3 0.442820096243914 0.166634696770945 -0.145068391221315 0.569239559252949 MirTarget -0.146973333951251 0.000145374061338494 NA NA NA hsa-miR-495-3p SMAD3 -0.0847115949846082 0.763475496144456 -0.145068391221315 0.569239559252949 mirMAP -0.147079833458788 0.000814867470605654 NA NA NA hsa-miR-497-5p SMAD3 0.0257087130056286 0.918145413833358 -0.145068391221315 0.569239559252949 MirTarget -0.149416186909323 0.00253073754447704 NA NA NA hsa-miR-501-5p SMAD3 1.93654809410041 1.3779381780759e-10 -0.145068391221315 0.569239559252949 mirMAP -0.178593095060563 1.2547872342843e-05 NA NA NA hsa-miR-589-3p SMAD3 2.51971841868825 2.39125940264107e-11 -0.145068391221315 0.569239559252949 mirMAP -0.112359264624293 0.0019298395243008 NA NA NA hsa-let-7f-1-3p SMAD4 1.55054488387679 7.31326775537952e-11 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106405479232356 4.39371133743738e-05 NA NA NA hsa-miR-140-5p SMAD4 0.844753502512594 3.73722278438606e-05 -0.586921155134023 3.52416916552263e-06 miRanda -0.114517150132142 0.000134319769998401 NA NA NA hsa-miR-146b-5p SMAD4 1.75587235896724 1.15724631266659e-07 -0.586921155134023 3.52416916552263e-06 PITA;miRanda;miRNATAP -0.103959435086478 8.75874581151263e-09 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-186-5p SMAD4 1.47445398888668 3.0781726595413e-15 -0.586921155134023 3.52416916552263e-06 miRNAWalker2_validate;mirMAP -0.107040467643529 0.000873099593755318 NA NA NA hsa-miR-2355-5p SMAD4 1.32510310704724 8.25139516692683e-07 -0.586921155134023 3.52416916552263e-06 MirTarget -0.100237269384076 8.83439826066143e-06 NA NA NA hsa-miR-26b-5p SMAD4 0.885393662798425 3.2116297961629e-06 -0.586921155134023 3.52416916552263e-06 MirTarget;miRNATAP -0.101564603889141 0.00171580634002753 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 1.66542180327138 4.93775737894805e-13 -0.586921155134023 3.52416916552263e-06 MirTarget -0.13536279837513 1.62491622147447e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.9016323452565 1.43092834643601e-14 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.121709073519824 3.8975183335493e-07 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-362-3p SMAD4 2.0756816987665 3.89026064579331e-12 -0.586921155134023 3.52416916552263e-06 miRNATAP -0.105074125190041 3.2218791406447e-07 NA NA NA hsa-miR-576-5p SMAD4 2.20467023993664 3.4053475193793e-19 -0.586921155134023 3.52416916552263e-06 mirMAP -0.106133513564488 8.78863207489382e-06 NA NA NA hsa-let-7b-3p SMO 0.868207752019623 1.30460056774366e-05 -0.919511442372506 0.0301537564555263 MirTarget;miRNATAP -0.248156670163619 0.0163839106472117 NA NA NA hsa-let-7f-1-3p SMO 1.55054488387679 7.31326775537952e-11 -0.919511442372506 0.0301537564555263 MirTarget -0.219704249761191 0.0119291680982287 NA NA NA hsa-miR-330-5p SMO 1.15100069700871 4.85551805046014e-07 -0.919511442372506 0.0301537564555263 MirTarget;miRanda -0.305063167390636 0.000612502882279379 NA NA NA hsa-miR-331-3p SMO 2.28379581858927 1.99663919173155e-18 -0.919511442372506 0.0301537564555263 miRNAWalker2_validate -0.25471564113182 0.000756861375102029 NA NA NA hsa-let-7a-5p SOCS1 0.618599506841644 2.76973453058748e-05 -0.629318194430381 0.0524798142155934 TargetScan -0.524623732028849 9.31061306901633e-07 NA NA NA hsa-miR-324-5p SOCS1 2.95683728155095 1.32960514360912e-20 -0.629318194430381 0.0524798142155934 miRanda -0.142997338528533 0.00240679820899766 NA NA NA hsa-miR-331-3p SOCS1 2.28379581858927 1.99663919173155e-18 -0.629318194430381 0.0524798142155934 PITA -0.246494631617319 1.86001854394675e-05 NA NA NA hsa-miR-582-5p SOCS1 0.609226359812689 0.032988717891497 -0.629318194430381 0.0524798142155934 PITA -0.163975655823809 0.00288904547616844 NA NA NA hsa-miR-141-3p SOX17 5.02396127982626 2.19224509139725e-24 -2.94798887132292 6.52451561011194e-21 TargetScan -0.256726942553231 1.9475675823917e-18 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-26b-5p SOX17 0.885393662798425 3.2116297961629e-06 -2.94798887132292 6.52451561011194e-21 miRNATAP -0.248054912544758 0.00315615311176464 NA NA NA hsa-miR-330-5p SOX17 1.15100069700871 4.85551805046014e-07 -2.94798887132292 6.52451561011194e-21 miRanda -0.30637343726308 8.69430797835861e-06 NA NA NA hsa-miR-362-3p SOX17 2.0756816987665 3.89026064579331e-12 -2.94798887132292 6.52451561011194e-21 miRanda;miRNATAP -0.141260036995058 0.00878893299297899 NA NA NA hsa-miR-421 SOX17 1.17791565395543 6.78526676976629e-06 -2.94798887132292 6.52451561011194e-21 miRanda -0.30262015358656 4.92995991235237e-07 NA NA NA hsa-miR-590-3p SOX17 2.59289455139753 1.03200520972022e-21 -2.94798887132292 6.52451561011194e-21 miRanda;miRNATAP -0.448317394761125 1.03655081728629e-15 NA NA NA hsa-miR-590-5p SOX17 3.18300989862077 2.06813568597893e-26 -2.94798887132292 6.52451561011194e-21 miRanda -0.408104262709017 2.5149436420718e-16 NA NA NA hsa-miR-132-3p SOX2 0.156276992635384 0.408190812100704 -0.323595368728617 0.681514582034885 miRNATAP -0.441801452513654 0.0310238644643665 NA NA NA hsa-miR-34a-5p SOX2 1.9016323452565 1.43092834643601e-14 -0.323595368728617 0.681514582034885 miRNAWalker2_validate;miRTarBase -0.418653713804836 0.00524040301276666 NA NA NA hsa-miR-1-3p SOX9 -3.48370702447685 1.98579484008516e-13 1.13040984801329 0.0354704160206486 MirTarget -0.105386330393545 0.0482633528242291 NA NA NA hsa-miR-101-3p SOX9 0.522819989585461 0.00375627731618038 1.13040984801329 0.0354704160206486 miRNAWalker2_validate;miRNATAP -0.539844940330791 0.000204431201243516 23178713 Ectopic expression of miR-101 significantly inhibited HCC cell proliferation and tumorigenicity by targeting SOX9; Therefore miR-101 may suppress HCC tumor progression by down-regulating SOX9 progression liver cancer hsa-miR-30b-5p SOX9 0.800822374912712 0.000133601914525413 1.13040984801329 0.0354704160206486 MirTarget -0.318002910195815 0.010685542852497 NA NA NA hsa-miR-30c-5p SOX9 0.778774633108 0.000285599212429136 1.13040984801329 0.0354704160206486 MirTarget;miRNATAP -0.365035942002407 0.00266402091223478 NA NA NA hsa-miR-30d-5p SOX9 0.675423997639582 0.00270618816039773 1.13040984801329 0.0354704160206486 MirTarget;miRNATAP -0.434664007643438 0.000170467688323101 NA NA NA hsa-miR-30e-5p SOX9 1.23904909539663 1.35561917122157e-09 1.13040984801329 0.0354704160206486 MirTarget -0.485497322443767 0.000110039719791244 NA NA NA hsa-miR-320a SOX9 0.438165828017084 0.0390159073347133 1.13040984801329 0.0354704160206486 miRanda;miRNATAP -0.277550082459125 0.0250284600790132 NA NA NA hsa-miR-33a-3p SOX9 1.72765312072219 1.51784443453521e-07 1.13040984801329 0.0354704160206486 mirMAP -0.175796869781922 0.0410958416143202 NA NA NA hsa-miR-582-3p SOX9 0.00876844181512659 0.977126166214707 1.13040984801329 0.0354704160206486 PITA;miRNATAP -0.384458473099014 5.81907031889053e-06 NA NA NA hsa-miR-582-5p SOX9 0.609226359812689 0.032988717891497 1.13040984801329 0.0354704160206486 PITA;miRNATAP -0.335428447645588 0.000227574582108014 NA NA NA hsa-miR-29b-3p SPEN 1.65828197923813 1.02676780888141e-09 -0.144480942767942 0.285543141625868 MirTarget;miRNATAP -0.138800698170327 2.16409845490653e-09 NA NA NA hsa-miR-101-3p SPOP 0.522819989585461 0.00375627731618038 -0.842957172960975 9.96357757521237e-14 MirTarget;miRNATAP -0.118928986236232 0.00014861943260671 NA NA NA hsa-miR-125a-3p SPOP 1.24490295132072 5.26925231010328e-06 -0.842957172960975 9.96357757521237e-14 miRanda -0.109224841637335 6.15430859322996e-08 NA NA NA hsa-miR-140-3p SPOP 0.0608890720479334 0.727716871248724 -0.842957172960975 9.96357757521237e-14 miRNATAP -0.117694355223791 0.000301938928779346 NA NA NA hsa-miR-21-3p SPOP 2.19296355304364 4.63665722759779e-15 -0.842957172960975 9.96357757521237e-14 MirTarget -0.12150884551281 1.95392502331867e-10 NA NA NA hsa-miR-331-3p SPOP 2.28379581858927 1.99663919173155e-18 -0.842957172960975 9.96357757521237e-14 MirTarget -0.125148109604442 7.91363150236128e-10 NA NA NA hsa-miR-342-3p SPOP 1.49115144672245 1.43879249744621e-07 -0.842957172960975 9.96357757521237e-14 miRanda -0.116383253009907 1.51659307994603e-09 NA NA NA hsa-miR-423-5p SPOP 0.963563145758616 9.86109015204915e-07 -0.842957172960975 9.96357757521237e-14 MirTarget -0.142973760498048 3.94533620297372e-07 NA NA NA hsa-miR-589-5p SPOP 1.71990116752371 8.310889042056e-14 -0.842957172960975 9.96357757521237e-14 MirTarget -0.120017621857035 3.44106091628863e-07 NA NA NA hsa-miR-624-5p SPOP 1.47043111118159 8.25080691741182e-09 -0.842957172960975 9.96357757521237e-14 MirTarget -0.101526179073202 5.89723838858196e-06 NA NA NA hsa-miR-7-1-3p SPOP 1.84950311431067 1.25300363397654e-13 -0.842957172960975 9.96357757521237e-14 mirMAP -0.106982365455765 8.54726724408968e-07 NA NA NA hsa-miR-130a-3p SRC 2.02021855058359 1.26427102520415e-11 0.570460331165611 0.0110129276753055 mirMAP -0.142068870145428 6.08308617638817e-05 NA NA NA hsa-miR-132-5p SRC 0.0013490685505323 0.995763495755809 0.570460331165611 0.0110129276753055 MirTarget -0.220312723053475 6.86379054233987e-07 NA NA NA hsa-miR-193a-3p SRC 1.60460546928078 2.86169793322984e-07 0.570460331165611 0.0110129276753055 mirMAP -0.17664648706064 1.96273303635261e-07 NA NA NA hsa-miR-221-5p SRC -0.745357436702497 0.081887809839391 0.570460331165611 0.0110129276753055 MirTarget -0.114257533151616 8.97086699137357e-06 NA NA NA hsa-miR-2355-5p SRC 1.32510310704724 8.25139516692683e-07 0.570460331165611 0.0110129276753055 mirMAP -0.172520855037043 1.46783203304486e-05 NA NA NA hsa-miR-338-5p SRC -0.577691606146419 0.0472212680542825 0.570460331165611 0.0110129276753055 PITA;miRNATAP -0.195583102051808 1.56647881831225e-07 NA NA NA hsa-let-7a-3p STK40 1.42015538786275 7.03375209382654e-13 -1.26400207575733 1.00508386470648e-16 MirTarget;miRNATAP -0.186450023379035 6.6587527447072e-07 NA NA NA hsa-let-7a-5p STK40 0.618599506841644 2.76973453058748e-05 -1.26400207575733 1.00508386470648e-16 MirTarget;TargetScan;miRNATAP -0.289732433903863 2.13832104956112e-08 NA NA NA hsa-let-7b-3p STK40 0.868207752019623 1.30460056774366e-05 -1.26400207575733 1.00508386470648e-16 MirTarget;miRNATAP -0.182214396444423 1.63814832775847e-06 NA NA NA hsa-let-7b-5p STK40 0.604314269683977 0.00140009936153214 -1.26400207575733 1.00508386470648e-16 MirTarget;miRNATAP -0.187419555609921 3.3670501271711e-06 NA NA NA hsa-let-7d-5p STK40 1.33236798905207 1.1741085658466e-13 -1.26400207575733 1.00508386470648e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.247586166030122 1.67652088446019e-09 NA NA NA hsa-let-7e-5p STK40 0.860104282510173 6.04758298373779e-05 -1.26400207575733 1.00508386470648e-16 MirTarget;miRNATAP -0.14207975116361 6.08455181416027e-05 NA NA NA hsa-let-7f-5p STK40 0.495648727272215 0.00355972741198794 -1.26400207575733 1.00508386470648e-16 MirTarget;miRNATAP -0.122958030939438 0.00685325715254017 NA NA NA hsa-let-7g-3p STK40 3.26398061402445 3.96263126107645e-25 -1.26400207575733 1.00508386470648e-16 mirMAP -0.160506668004152 2.37690247178991e-12 NA NA NA hsa-let-7g-5p STK40 1.20061455355116 1.50237505511483e-12 -1.26400207575733 1.00508386470648e-16 MirTarget;miRNATAP -0.261429828898585 2.21082653987526e-09 NA NA NA hsa-miR-103a-3p STK40 1.44083190496858 1.53799939616416e-13 -1.26400207575733 1.00508386470648e-16 miRNAWalker2_validate -0.2195096729818 6.19570147744215e-09 NA NA NA hsa-miR-106b-3p STK40 1.74115042407425 7.96524575137272e-14 -1.26400207575733 1.00508386470648e-16 mirMAP -0.160582945647283 3.76497512063439e-07 NA NA NA hsa-miR-106b-5p STK40 2.46782146831112 1.36171495805632e-23 -1.26400207575733 1.00508386470648e-16 miRNAWalker2_validate -0.201383790953109 2.27273173734592e-12 NA NA NA hsa-miR-125a-5p STK40 0.599529391575274 0.0102300147180307 -1.26400207575733 1.00508386470648e-16 mirMAP -0.119554675885335 0.000258100364292847 NA NA NA hsa-miR-128-3p STK40 1.63756041666078 6.79626586407187e-14 -1.26400207575733 1.00508386470648e-16 MirTarget -0.165207710808575 1.00541192973271e-06 NA NA NA hsa-miR-15a-5p STK40 2.34669284378787 1.69544424500258e-23 -1.26400207575733 1.00508386470648e-16 mirMAP -0.16671344291851 4.57432220182707e-08 NA NA NA hsa-miR-15b-5p STK40 1.57112623124278 9.14247846750597e-13 -1.26400207575733 1.00508386470648e-16 mirMAP -0.193035421508232 8.1424419594089e-09 NA NA NA hsa-miR-16-5p STK40 1.75824877145857 1.68592440033108e-16 -1.26400207575733 1.00508386470648e-16 mirMAP -0.210643249383825 6.61832633230625e-10 NA NA NA hsa-miR-17-3p STK40 2.2704817679209 1.1667437320211e-22 -1.26400207575733 1.00508386470648e-16 mirMAP -0.192456359807951 4.24904822050737e-10 NA NA NA hsa-miR-183-5p STK40 4.19757025992371 4.79612296318304e-26 -1.26400207575733 1.00508386470648e-16 miRNAWalker2_validate -0.114407403706615 9.23378042242142e-11 NA NA NA hsa-miR-185-5p STK40 2.34016206907488 1.17481626642022e-26 -1.26400207575733 1.00508386470648e-16 MirTarget -0.178768296831859 3.73283981459226e-08 NA NA NA hsa-miR-1976 STK40 2.06550563678192 7.81396978619772e-18 -1.26400207575733 1.00508386470648e-16 mirMAP -0.155196503029921 3.11330116608042e-07 NA NA NA hsa-miR-21-5p STK40 2.73773305747971 1.38864982139576e-43 -1.26400207575733 1.00508386470648e-16 MirTarget;miRNATAP -0.196282429949783 1.25056368318807e-08 NA NA NA hsa-miR-26b-3p STK40 2.18464160365372 2.11543189388328e-18 -1.26400207575733 1.00508386470648e-16 miRNATAP -0.162401056653165 2.19730097547771e-08 NA NA NA hsa-miR-29b-3p STK40 1.65828197923813 1.02676780888141e-09 -1.26400207575733 1.00508386470648e-16 mirMAP -0.102277425945877 0.000203480826930084 NA NA NA hsa-miR-301a-3p STK40 2.81024345929638 2.29784847962242e-17 -1.26400207575733 1.00508386470648e-16 mirMAP -0.141551868863708 7.54782626911404e-10 NA NA NA hsa-miR-30b-3p STK40 0.834142820354026 0.000972582820878813 -1.26400207575733 1.00508386470648e-16 mirMAP -0.103177607044792 0.000649908961304551 NA NA NA hsa-miR-31-5p STK40 3.59165123035072 2.27423212057482e-07 -1.26400207575733 1.00508386470648e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.113140421679633 1.46852818112695e-25 NA NA NA hsa-miR-320a STK40 0.438165828017084 0.0390159073347133 -1.26400207575733 1.00508386470648e-16 miRanda -0.16447310961818 4.77558255638649e-06 NA NA NA hsa-miR-320b STK40 1.55692969039548 1.41071034251915e-08 -1.26400207575733 1.00508386470648e-16 miRanda -0.17012123897205 2.56753907716844e-10 NA NA NA hsa-miR-361-3p STK40 1.07367425434318 1.73142774168958e-09 -1.26400207575733 1.00508386470648e-16 mirMAP -0.174857930855938 3.60486127439982e-05 NA NA NA hsa-miR-3614-5p STK40 2.17736331059655 2.19144831318484e-08 -1.26400207575733 1.00508386470648e-16 mirMAP -0.110811794230702 1.8524457980768e-08 NA NA NA hsa-miR-423-5p STK40 0.963563145758616 9.86109015204915e-07 -1.26400207575733 1.00508386470648e-16 MirTarget -0.233925127136182 7.62886213329036e-10 NA NA NA hsa-miR-424-5p STK40 1.61930224569578 1.89642549274994e-10 -1.26400207575733 1.00508386470648e-16 mirMAP -0.103103683340038 0.000457210644215445 NA NA NA hsa-miR-454-3p STK40 2.47234127820054 1.12878018736016e-21 -1.26400207575733 1.00508386470648e-16 mirMAP -0.178889604674007 3.01826245519981e-10 NA NA NA hsa-miR-484 STK40 1.81844463411787 1.82951571230938e-15 -1.26400207575733 1.00508386470648e-16 mirMAP -0.157365904051067 9.64033750689664e-07 NA NA NA hsa-miR-505-5p STK40 1.89243395287645 9.82003586561819e-12 -1.26400207575733 1.00508386470648e-16 mirMAP -0.110252588819015 3.73270252465365e-05 NA NA NA hsa-miR-590-5p STK40 3.18300989862077 2.06813568597893e-26 -1.26400207575733 1.00508386470648e-16 PITA;miRNATAP -0.126915265165294 1.88034348254719e-07 NA NA NA hsa-miR-664a-5p STK40 0.505019913598436 0.032933350691651 -1.26400207575733 1.00508386470648e-16 mirMAP -0.117843093387389 0.000277309706052086 NA NA NA hsa-miR-96-5p STK40 4.89433085814374 1.92000659886961e-31 -1.26400207575733 1.00508386470648e-16 mirMAP -0.122105257816889 4.27576300681893e-13 NA NA NA hsa-miR-98-5p STK40 1.11154309866014 1.24143909012085e-08 -1.26400207575733 1.00508386470648e-16 MirTarget -0.136981365922319 0.000405455605502909 NA NA NA hsa-miR-99b-3p STK40 1.62436885280973 8.09988670773273e-10 -1.26400207575733 1.00508386470648e-16 mirMAP -0.119129208870164 2.42698905087273e-05 NA NA NA hsa-miR-130a-3p SUFU 2.02021855058359 1.26427102520415e-11 -0.0204432931990537 0.887320324296748 mirMAP -0.136550066815664 1.01190442787176e-09 NA NA NA hsa-miR-155-5p SUFU 1.20164021433135 0.00086170622431261 -0.0204432931990537 0.887320324296748 miRNATAP -0.144649724718561 6.95423008437294e-15 NA NA NA hsa-miR-342-3p SUFU 1.49115144672245 1.43879249744621e-07 -0.0204432931990537 0.887320324296748 miRanda -0.112584635037766 2.73899316702374e-06 NA NA NA hsa-miR-361-3p SUFU 1.07367425434318 1.73142774168958e-09 -0.0204432931990537 0.887320324296748 mirMAP -0.119761459714565 0.00196021916052117 NA NA NA hsa-miR-130b-5p SYK 2.9963110846538 1.98883029416455e-18 -0.135539658170963 0.612831284144568 mirMAP -0.106397988982408 0.00426064698201807 NA NA NA hsa-miR-421 SYK 1.17791565395543 6.78526676976629e-06 -0.135539658170963 0.612831284144568 miRanda -0.151701272172841 0.00203753549510699 NA NA NA hsa-miR-99b-3p SYK 1.62436885280973 8.09988670773273e-10 -0.135539658170963 0.612831284144568 miRNAWalker2_validate -0.227233220412288 1.885196945473e-06 NA NA NA hsa-miR-127-3p TBX3 -0.6279281852298 0.0400829468424132 -0.0966414054021554 0.855879575923682 miRanda -0.36422127714649 1.31846057850581e-05 NA NA NA hsa-miR-142-5p TBX3 1.17581605694506 0.0018174701991234 -0.0966414054021554 0.855879575923682 PITA -0.506841547170895 1.43922236632731e-14 NA NA NA hsa-miR-299-5p TBX3 -0.274550626427337 0.386834031856446 -0.0966414054021554 0.855879575923682 miRNATAP -0.422972526382457 1.54860419354906e-07 NA NA NA hsa-miR-29a-5p TBX3 1.46749674755271 3.34605004270294e-07 -0.0966414054021554 0.855879575923682 mirMAP -0.580169698110027 2.62555745407723e-10 NA NA NA hsa-miR-92b-3p TBX3 1.20409245530001 3.41055816361655e-06 -0.0966414054021554 0.855879575923682 miRNATAP -0.366971551821285 0.000184950190121332 NA NA NA hsa-miR-126-5p TET1 0.895338176458417 2.33372756450713e-05 0.295809882045288 0.293936170527045 mirMAP -0.135112411496957 0.0360750840794493 NA NA NA hsa-miR-29b-3p TET1 1.65828197923813 1.02676780888141e-09 0.295809882045288 0.293936170527045 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.261774002222008 7.62280194548691e-08 25367851;25616722 Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis liver cancer;liver cancer hsa-miR-29c-3p TET1 -0.00968972577705429 0.97099586346872 0.295809882045288 0.293936170527045 MirTarget;miRNATAP -0.297195480515772 4.20770231085309e-09 NA NA NA hsa-let-7a-2-3p TET2 0.0400317820791161 0.91528727576685 -0.0355625714212948 0.838982280854655 MirTarget -0.111748010502841 7.28834250441194e-07 NA NA NA hsa-let-7i-5p TET2 0.412877696970403 0.00622731051981756 -0.0355625714212948 0.838982280854655 miRNATAP -0.284116330009307 4.68725319356014e-07 NA NA NA hsa-miR-125b-5p TET2 -1.16462950151259 0.000288900271798384 -0.0355625714212948 0.838982280854655 miRNATAP -0.131317849786881 3.78772012166397e-07 NA NA NA hsa-miR-140-5p TET2 0.844753502512594 3.73722278438606e-05 -0.0355625714212948 0.838982280854655 miRanda -0.15335298932979 0.000188837541400363 NA NA NA hsa-miR-142-5p TET2 1.17581605694506 0.0018174701991234 -0.0355625714212948 0.838982280854655 mirMAP -0.111103840583718 4.65401045279422e-07 NA NA NA hsa-miR-145-3p TET2 -2.01995772419904 2.14791468879561e-11 -0.0355625714212948 0.838982280854655 mirMAP -0.100863537664469 0.000213363555426303 NA NA NA hsa-miR-145-5p TET2 -1.55259331973517 9.97889123247165e-07 -0.0355625714212948 0.838982280854655 miRNATAP -0.118594888056509 5.47133151807368e-06 NA NA NA hsa-miR-146b-3p TET2 1.10569195233795 0.000660632782194023 -0.0355625714212948 0.838982280854655 miRNATAP -0.201447681253942 8.32501224399377e-16 NA NA NA hsa-miR-146b-5p TET2 1.75587235896724 1.15724631266659e-07 -0.0355625714212948 0.838982280854655 miRanda -0.191648286913799 3.31059872266425e-15 NA NA NA hsa-miR-155-5p TET2 1.20164021433135 0.00086170622431261 -0.0355625714212948 0.838982280854655 mirMAP -0.1621897006744 8.91132090665488e-13 NA NA NA hsa-miR-193a-3p TET2 1.60460546928078 2.86169793322984e-07 -0.0355625714212948 0.838982280854655 miRanda -0.11929336887434 6.5062348258608e-06 NA NA NA hsa-miR-199a-5p TET2 0.592984035153911 0.0674836634175293 -0.0355625714212948 0.838982280854655 miRanda;miRNATAP -0.123539479982857 1.68128874587335e-06 NA NA NA hsa-miR-29a-3p TET2 -0.35074463683376 0.161238718982428 -0.0355625714212948 0.838982280854655 miRNATAP -0.194908896426655 5.11941076784628e-09 NA NA NA hsa-miR-338-5p TET2 -0.577691606146419 0.0472212680542825 -0.0355625714212948 0.838982280854655 mirMAP;miRNATAP -0.117539057550798 5.47761934369514e-05 NA NA NA hsa-miR-340-5p TET2 0.30282999308409 0.157744789519131 -0.0355625714212948 0.838982280854655 mirMAP -0.106917848303567 0.00710530089066966 NA NA NA hsa-miR-374b-5p TET2 0.0654362503857184 0.722673188879465 -0.0355625714212948 0.838982280854655 mirMAP;miRNATAP -0.14450538854148 0.00183399319746454 NA NA NA hsa-miR-655-3p TET2 0.485339318272148 0.137014658258732 -0.0355625714212948 0.838982280854655 MirTarget -0.116930529304508 7.76897815335532e-06 NA NA NA hsa-let-7a-5p TGFBR1 0.618599506841644 2.76973453058748e-05 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.244428925468535 0.000440383623292106 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-let-7b-5p TGFBR1 0.604314269683977 0.00140009936153214 -0.531745632851025 0.0111481565689226 miRNATAP -0.164395211205111 0.002334077702266 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7d-5p TGFBR1 1.33236798905207 1.1741085658466e-13 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.249677273322744 5.91436156062502e-06 NA NA NA hsa-let-7e-5p TGFBR1 0.860104282510173 6.04758298373779e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.165779353656999 0.000445651685953496 NA NA NA hsa-let-7f-5p TGFBR1 0.495648727272215 0.00355972741198794 -0.531745632851025 0.0111481565689226 miRNATAP -0.212539435969951 0.000421071580866339 NA NA NA hsa-let-7g-5p TGFBR1 1.20061455355116 1.50237505511483e-12 -0.531745632851025 0.0111481565689226 miRNATAP -0.498242721643013 1.58222259474873e-18 NA NA NA hsa-miR-101-3p TGFBR1 0.522819989585461 0.00375627731618038 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRNATAP -0.356084641759078 1.678272043475e-10 NA NA NA hsa-miR-126-5p TGFBR1 0.895338176458417 2.33372756450713e-05 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.153123735128566 0.00137633400200009 NA NA NA hsa-miR-128-3p TGFBR1 1.63756041666078 6.79626586407187e-14 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate;miRTarBase -0.248098643403413 2.90608464652714e-08 NA NA NA hsa-miR-130b-3p TGFBR1 3.5350292994509 1.73934183852569e-27 -0.531745632851025 0.0111481565689226 miRNATAP -0.134668437053487 3.34039315804437e-06 NA NA NA hsa-miR-16-2-3p TGFBR1 2.31623086727196 4.29838149388188e-20 -0.531745632851025 0.0111481565689226 mirMAP -0.118014665876922 0.00216991899384218 NA NA NA hsa-miR-181c-5p TGFBR1 1.58587920618301 1.57506918816933e-10 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.16918051477343 2.32913877572708e-05 NA NA NA hsa-miR-186-5p TGFBR1 1.47445398888668 3.0781726595413e-15 -0.531745632851025 0.0111481565689226 mirMAP -0.261901522962087 6.15270096138054e-07 NA NA NA hsa-miR-200b-3p TGFBR1 3.78235093249346 3.18343003239465e-14 -0.531745632851025 0.0111481565689226 mirMAP -0.185163040320424 3.55754064059769e-23 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-2110 TGFBR1 1.16625590651194 6.4784195289885e-05 -0.531745632851025 0.0111481565689226 miRNATAP -0.203122265430452 3.02839928126399e-08 NA NA NA hsa-miR-301a-3p TGFBR1 2.81024345929638 2.29784847962242e-17 -0.531745632851025 0.0111481565689226 miRNATAP -0.188558650494062 6.94428278524489e-10 NA NA NA hsa-miR-32-3p TGFBR1 2.02436999565685 5.94091197945307e-09 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.116207615183923 0.000365699800115398 NA NA NA hsa-miR-3200-3p TGFBR1 2.70510522077868 1.90469509928484e-08 -0.531745632851025 0.0111481565689226 miRNATAP -0.120700105473579 2.69621919466987e-08 NA NA NA hsa-miR-320a TGFBR1 0.438165828017084 0.0390159073347133 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.326176915517583 4.1064210958607e-12 NA NA NA hsa-miR-320b TGFBR1 1.55692969039548 1.41071034251915e-08 -0.531745632851025 0.0111481565689226 PITA;miRanda;miRNATAP -0.191128801910238 1.11537638054288e-07 NA NA NA hsa-miR-330-3p TGFBR1 0.876747334239085 0.00073709016089703 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.231238826647919 1.69019842696319e-09 NA NA NA hsa-miR-331-3p TGFBR1 2.28379581858927 1.99663919173155e-18 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.227588969955072 5.92157067223612e-10 NA NA NA hsa-miR-361-5p TGFBR1 0.971859117235239 5.30236555707088e-09 -0.531745632851025 0.0111481565689226 miRanda;mirMAP;miRNATAP -0.327512599032841 4.9385335452745e-08 NA NA NA hsa-miR-374a-5p TGFBR1 0.484615721953736 0.0042981729815149 -0.531745632851025 0.0111481565689226 mirMAP -0.1725550403971 0.00437986725180039 NA NA NA hsa-miR-429 TGFBR1 4.48815175680773 2.44117492218206e-17 -0.531745632851025 0.0111481565689226 miRanda;miRNATAP -0.169764852224625 2.30995613689702e-22 NA NA NA hsa-miR-454-3p TGFBR1 2.47234127820054 1.12878018736016e-21 -0.531745632851025 0.0111481565689226 mirMAP;miRNATAP -0.205677505304361 6.16209314820036e-08 NA NA NA hsa-miR-500a-5p TGFBR1 1.72110365584658 3.0807246212659e-10 -0.531745632851025 0.0111481565689226 mirMAP -0.111391945877042 0.0022402772038843 NA NA NA hsa-miR-576-5p TGFBR1 2.20467023993664 3.4053475193793e-19 -0.531745632851025 0.0111481565689226 mirMAP -0.201284779052 2.74992936654638e-07 NA NA NA hsa-miR-589-3p TGFBR1 2.51971841868825 2.39125940264107e-11 -0.531745632851025 0.0111481565689226 mirMAP -0.104859492543737 0.000438540974273448 NA NA NA hsa-miR-590-3p TGFBR1 2.59289455139753 1.03200520972022e-21 -0.531745632851025 0.0111481565689226 PITA;miRanda;mirMAP;miRNATAP -0.139228339501584 0.000139021577037225 NA NA NA hsa-miR-590-5p TGFBR1 3.18300989862077 2.06813568597893e-26 -0.531745632851025 0.0111481565689226 PITA;miRanda -0.158386241001983 1.04882834086946e-06 NA NA NA hsa-miR-664a-3p TGFBR1 0.634721925861133 0.00520070178640421 -0.531745632851025 0.0111481565689226 mirMAP -0.321621318973717 1.70943055444078e-13 NA NA NA hsa-miR-769-5p TGFBR1 1.82023760596845 9.6815886564134e-14 -0.531745632851025 0.0111481565689226 PITA;miRNATAP -0.228524293799953 9.85398652877069e-09 NA NA NA hsa-miR-944 TGFBR1 2.91186649218281 1.31574753528144e-06 -0.531745632851025 0.0111481565689226 PITA;mirMAP -0.104949150832685 4.75355134217921e-10 NA NA NA hsa-miR-96-5p TGFBR1 4.89433085814374 1.92000659886961e-31 -0.531745632851025 0.0111481565689226 TargetScan;miRNATAP -0.138876787398621 7.90055950171446e-10 NA NA NA hsa-miR-98-5p TGFBR1 1.11154309866014 1.24143909012085e-08 -0.531745632851025 0.0111481565689226 miRNAWalker2_validate -0.401926180925558 8.43130029155261e-16 NA NA NA hsa-miR-106a-5p TGFBR2 2.48882002962836 1.99757727374521e-12 -1.5612933795263 2.09571393414153e-11 miRTarBase;miRNATAP -0.174237668172683 2.7024970040951e-08 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 2.46782146831112 1.36171495805632e-23 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.446340567749987 1.4640429348369e-26 NA NA NA hsa-miR-107 TGFBR2 1.30977326593435 1.30372468603965e-11 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.33082940368913 1.15759545655126e-08 NA NA NA hsa-miR-130a-3p TGFBR2 2.02021855058359 1.26427102520415e-11 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.187222356261558 5.74404160623046e-07 NA NA NA hsa-miR-130b-3p TGFBR2 3.5350292994509 1.73934183852569e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.279678154840768 1.9762101701233e-18 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 3.2710598467455 9.93128340539455e-27 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.302277707820119 6.79145607037112e-19 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 1.47445398888668 3.0781726595413e-15 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.383453901935314 9.23917606419292e-11 NA NA NA hsa-miR-18a-5p TGFBR2 3.78535678765353 3.72446596213886e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.25381972833671 2.41323249210829e-16 NA NA NA hsa-miR-19a-3p TGFBR2 3.42309334186656 3.02671914353412e-28 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.277232207383645 1.48488496649533e-16 NA NA NA hsa-miR-19b-3p TGFBR2 2.49529833021187 1.57028265846699e-23 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.351923320676886 1.03809079896527e-16 NA NA NA hsa-miR-20a-5p TGFBR2 3.15577933619191 4.19753346442454e-25 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29433840605417 1.11976352607645e-17 NA NA NA hsa-miR-20b-5p TGFBR2 2.07706563022469 1.10107236083433e-05 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.105991731825053 9.98951097559816e-06 NA NA NA hsa-miR-21-5p TGFBR2 2.73773305747971 1.38864982139576e-43 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.1959869038848 0.000202473977886908 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-23a-3p TGFBR2 1.00493340843378 2.55313889288924e-08 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.150743460056457 0.0183024849464915 NA NA NA hsa-miR-29b-2-5p TGFBR2 0.910668640983475 0.00666655585493488 -1.5612933795263 2.09571393414153e-11 mirMAP -0.106614907621936 0.00190433915326164 NA NA NA hsa-miR-301a-3p TGFBR2 2.81024345929638 2.29784847962242e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.303245579782603 4.36341401740489e-19 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320a TGFBR2 0.438165828017084 0.0390159073347133 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.147256255771787 0.0072521693939925 NA NA NA hsa-miR-320b TGFBR2 1.55692969039548 1.41071034251915e-08 -1.5612933795263 2.09571393414153e-11 miRanda;miRNATAP -0.259785049714809 1.72104577406335e-10 NA NA NA hsa-miR-335-3p TGFBR2 3.08791651139852 5.31309869723517e-12 -1.5612933795263 2.09571393414153e-11 mirMAP -0.116451466105744 2.86501897855708e-06 NA NA NA hsa-miR-335-5p TGFBR2 1.77247705492746 2.22457658872091e-06 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.108328975461909 0.000362366652132911 NA NA NA hsa-miR-33a-3p TGFBR2 1.72765312072219 1.51784443453521e-07 -1.5612933795263 2.09571393414153e-11 mirMAP -0.218324746449326 5.80693592871469e-09 NA NA NA hsa-miR-429 TGFBR2 4.48815175680773 2.44117492218206e-17 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.182453703283022 7.13137317316041e-20 NA NA NA hsa-miR-454-3p TGFBR2 2.47234127820054 1.12878018736016e-21 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.334757039971147 2.96928366293251e-15 NA NA NA hsa-miR-501-3p TGFBR2 1.83132758513743 1.10971547702065e-10 -1.5612933795263 2.09571393414153e-11 TargetScan -0.239042838968307 1.06476001924321e-09 NA NA NA hsa-miR-508-3p TGFBR2 1.05493034310846 0.0393857095042515 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.119214194503115 1.55583026735658e-07 NA NA NA hsa-miR-590-3p TGFBR2 2.59289455139753 1.03200520972022e-21 -1.5612933795263 2.09571393414153e-11 miRanda -0.298641027773627 2.0141780556407e-13 NA NA NA hsa-miR-590-5p TGFBR2 3.18300989862077 2.06813568597893e-26 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.294796030766598 2.66958610835318e-16 NA NA NA hsa-miR-9-5p TGFBR2 1.02304182473283 0.042901377604859 -1.5612933795263 2.09571393414153e-11 miRNATAP -0.120425377888386 8.76751437160767e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 2.06460102658973 1.44784291084757e-19 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate -0.402171657787311 8.61853387794715e-18 NA NA NA hsa-miR-93-5p TGFBR2 3.03961860136032 1.11672209617395e-24 -1.5612933795263 2.09571393414153e-11 miRNAWalker2_validate;miRNATAP -0.345215781740609 4.92958365930485e-23 NA NA NA hsa-miR-106b-5p TMEM127 2.46782146831112 1.36171495805632e-23 -0.205748179895958 0.0371206183757357 MirTarget -0.116679093750518 7.00858162618571e-11 NA NA NA hsa-miR-17-3p TMEM127 2.2704817679209 1.1667437320211e-22 -0.205748179895958 0.0371206183757357 mirMAP -0.123160069275031 1.16264167646015e-10 NA NA NA hsa-let-7a-5p TNFAIP3 0.618599506841644 2.76973453058748e-05 -1.62509801593269 1.6029261418853e-06 TargetScan;miRNATAP -0.420111000846509 0.000216775785489049 NA NA NA hsa-let-7b-5p TNFAIP3 0.604314269683977 0.00140009936153214 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.18090719963775 0.04102777070339 NA NA NA hsa-let-7d-5p TNFAIP3 1.33236798905207 1.1741085658466e-13 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.445219451938922 7.3054642669891e-07 NA NA NA hsa-let-7e-5p TNFAIP3 0.860104282510173 6.04758298373779e-05 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.326948708477224 2.12575428674536e-05 NA NA NA hsa-let-7f-5p TNFAIP3 0.495648727272215 0.00355972741198794 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.334343922657496 0.000693555536957464 NA NA NA hsa-let-7g-5p TNFAIP3 1.20061455355116 1.50237505511483e-12 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.514970749483471 6.60279188366171e-08 NA NA NA hsa-miR-107 TNFAIP3 1.30977326593435 1.30372468603965e-11 -1.62509801593269 1.6029261418853e-06 miRanda;miRNATAP -0.326897464892899 0.000101955056235218 NA NA NA hsa-miR-125a-5p TNFAIP3 0.599529391575274 0.0102300147180307 -1.62509801593269 1.6029261418853e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.311690818854823 1.08307997815276e-05 NA NA NA hsa-miR-141-3p TNFAIP3 5.02396127982626 2.19224509139725e-24 -1.62509801593269 1.6029261418853e-06 TargetScan -0.222404109517195 5.77674703240202e-13 NA NA NA hsa-miR-19a-3p TNFAIP3 3.42309334186656 3.02671914353412e-28 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.166370619085426 0.000844856648957625 NA NA NA hsa-miR-19b-3p TNFAIP3 2.49529833021187 1.57028265846699e-23 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.245550445341764 9.28293570666511e-05 NA NA NA hsa-miR-23b-3p TNFAIP3 -0.251132426825047 0.150200321210792 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.343762927050195 0.000353762622619547 NA NA NA hsa-miR-26b-5p TNFAIP3 0.885393662798425 3.2116297961629e-06 -1.62509801593269 1.6029261418853e-06 miRNAWalker2_validate -0.176539891936734 0.0435774798484677 NA NA NA hsa-miR-27b-5p TNFAIP3 0.393316367667332 0.051702301924024 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.199567283683966 0.0160885475957569 NA NA NA hsa-miR-330-3p TNFAIP3 0.876747334239085 0.00073709016089703 -1.62509801593269 1.6029261418853e-06 miRNATAP -0.253862548005074 6.3658962793607e-05 NA NA NA hsa-miR-429 TNFAIP3 4.48815175680773 2.44117492218206e-17 -1.62509801593269 1.6029261418853e-06 miRanda -0.249954262558494 4.53694428345232e-18 NA NA NA hsa-miR-139-5p TP63 -1.52606598644743 1.20474151350665e-08 1.87338981201605 0.00485134817625905 miRanda -0.394789396162926 0.000883786221910749 NA NA NA hsa-miR-193a-5p TP63 0.562511612963676 0.0239254699649222 1.87338981201605 0.00485134817625905 MirTarget -0.590324522180249 4.84134471974107e-06 NA NA NA hsa-miR-30a-5p TP63 -0.878357906436456 0.000509952992366057 1.87338981201605 0.00485134817625905 mirMAP -0.337766288345774 0.00819450510568385 NA NA NA hsa-miR-338-3p TP63 0.453166438193782 0.144583389707558 1.87338981201605 0.00485134817625905 miRanda -0.39467462718008 0.000142698321980991 NA NA NA hsa-miR-340-5p TP63 0.30282999308409 0.157744789519131 1.87338981201605 0.00485134817625905 miRNATAP -0.502569024198793 0.000924853099200159 NA NA NA hsa-miR-374b-5p TP63 0.0654362503857184 0.722673188879465 1.87338981201605 0.00485134817625905 mirMAP -0.381741132515578 0.0320649378219903 NA NA NA hsa-miR-92b-3p TP63 1.20409245530001 3.41055816361655e-06 1.87338981201605 0.00485134817625905 miRNATAP -0.434791158752495 0.000425364099544183 NA NA NA hsa-miR-15a-5p WT1 2.34669284378787 1.69544424500258e-23 0.551323653201556 0.432441907096104 miRNAWalker2_validate -0.59605011893962 1.26814902661351e-05 NA NA NA hsa-miR-16-5p WT1 1.75824877145857 1.68592440033108e-16 0.551323653201556 0.432441907096104 miRNAWalker2_validate -0.619617517184548 5.56501782655252e-05 NA NA NA hsa-miR-33a-3p WT1 1.72765312072219 1.51784443453521e-07 0.551323653201556 0.432441907096104 mirMAP -0.664142266808601 1.61973099285632e-09 NA NA NA hsa-miR-361-5p WT1 0.971859117235239 5.30236555707088e-09 0.551323653201556 0.432441907096104 PITA;miRanda;miRNATAP -0.93123476814416 4.02377951758194e-06 NA NA NA hsa-miR-429 WT1 4.48815175680773 2.44117492218206e-17 0.551323653201556 0.432441907096104 miRanda -0.521273461826592 9.52517209305686e-19 NA NA NA hsa-miR-590-3p WT1 2.59289455139753 1.03200520972022e-21 0.551323653201556 0.432441907096104 MirTarget;PITA;miRanda;miRNATAP -0.357462153061202 0.00358737928680485 NA NA NA hsa-miR-874-3p WT1 1.95617235160298 2.0152613104032e-12 0.551323653201556 0.432441907096104 MirTarget -0.41464018316067 0.00048566199562119 NA NA NA hsa-miR-125b-5p XIAP -1.16462950151259 0.000288900271798384 0.0185824727941606 0.900456705596673 miRNAWalker2_validate -0.134609008147354 6.17145452585339e-10 NA NA NA hsa-miR-146b-5p XIAP 1.75587235896724 1.15724631266659e-07 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.100792988978608 1.7835560220266e-06 NA NA NA hsa-miR-195-3p XIAP -0.658653229922836 0.0142127125129199 0.0185824727941606 0.900456705596673 mirMAP -0.109312331752852 5.17755048006399e-05 NA NA NA hsa-miR-26a-2-3p XIAP 0.823520019989974 0.00017092160823769 0.0185824727941606 0.900456705596673 mirMAP -0.103081650553247 0.0016975998669049 NA NA NA hsa-miR-23b-3p XPO1 -0.251132426825047 0.150200321210792 0.457972787249573 8.70743865516152e-06 miRNAWalker2_validate -0.117125887817145 5.12496667673309e-05 NA NA NA hsa-let-7a-3p YAP1 1.42015538786275 7.03375209382654e-13 -0.819514922156015 7.72909626929227e-05 mirMAP -0.143868237421206 0.00407737267220801 NA NA NA hsa-miR-126-5p YAP1 0.895338176458417 2.33372756450713e-05 -0.819514922156015 7.72909626929227e-05 mirMAP;miRNATAP -0.20913255045659 1.00448955629125e-05 NA NA NA hsa-miR-141-3p YAP1 5.02396127982626 2.19224509139725e-24 -0.819514922156015 7.72909626929227e-05 MirTarget;TargetScan -0.107645543722487 1.48207382564769e-08 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-141-5p YAP1 3.81419396518882 3.21977359736126e-18 -0.819514922156015 7.72909626929227e-05 miRNATAP -0.115091863383006 1.2801433096082e-07 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-16-2-3p YAP1 2.31623086727196 4.29838149388188e-20 -0.819514922156015 7.72909626929227e-05 mirMAP -0.212953175833193 1.75956128484433e-08 NA NA NA hsa-miR-186-5p YAP1 1.47445398888668 3.0781726595413e-15 -0.819514922156015 7.72909626929227e-05 MirTarget -0.306395992237321 3.69330739143338e-09 27073580 We observed that miR-186 was downregulated in several HCC cell lines and that it directly targets YAP1 mRNA; Overexpression of miR-186 in HCC cells significantly downregulates YAP1 mRNA and protein levels leading to downregulation of the Hippo signaling pathway which in turn severely inhibits HCC cell migration invasion and proliferation; Our study is the first to report the direct involvement of miR-186 in downregulating YAP1 and more significantly inhibiting HCC tumorigenesis and supports the role miR-186 as a potential therapeutic target in treating liver cancer cell migration;tumorigenesis liver cancer hsa-miR-200a-3p YAP1 4.59434485520731 6.38952518573476e-18 -0.819514922156015 7.72909626929227e-05 miRNAWalker2_validate;MirTarget -0.116465428459349 5.57675633205442e-11 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 3.78235093249346 3.18343003239465e-14 -0.819514922156015 7.72909626929227e-05 MirTarget -0.118880302646558 6.39640575477105e-10 NA NA NA hsa-miR-200c-3p YAP1 3.50132673580082 2.42716349086937e-15 -0.819514922156015 7.72909626929227e-05 MirTarget -0.104660951992012 1.60861074970143e-06 NA NA NA hsa-miR-26b-5p YAP1 0.885393662798425 3.2116297961629e-06 -0.819514922156015 7.72909626929227e-05 miRNAWalker2_validate -0.155271718784889 0.00345804443527015 NA NA NA hsa-miR-33a-3p YAP1 1.72765312072219 1.51784443453521e-07 -0.819514922156015 7.72909626929227e-05 mirMAP -0.1107445163667 0.000857537362043255 NA NA NA hsa-miR-34a-3p YAP1 1.75590866103657 8.02801510630657e-09 -0.819514922156015 7.72909626929227e-05 MirTarget -0.169740717437944 2.39565677986146e-06 NA NA NA hsa-miR-3607-3p YAP1 2.68532138541128 5.66716351955047e-14 -0.819514922156015 7.72909626929227e-05 mirMAP -0.135640017297819 1.14136526377216e-06 NA NA NA hsa-miR-361-3p YAP1 1.07367425434318 1.73142774168958e-09 -0.819514922156015 7.72909626929227e-05 MirTarget;PITA -0.240529277550041 1.70458312134651e-05 NA NA NA hsa-miR-361-5p YAP1 0.971859117235239 5.30236555707088e-09 -0.819514922156015 7.72909626929227e-05 miRanda -0.256453011333039 2.01754713090572e-05 NA NA NA hsa-miR-429 YAP1 4.48815175680773 2.44117492218206e-17 -0.819514922156015 7.72909626929227e-05 MirTarget;miRanda -0.11214625614141 3.9822420324722e-10 NA NA NA hsa-miR-484 YAP1 1.81844463411787 1.82951571230938e-15 -0.819514922156015 7.72909626929227e-05 PITA;miRNATAP -0.291798035788354 3.23193028417414e-12 NA NA NA hsa-miR-532-5p YAP1 1.55697650978597 1.57884735535196e-11 -0.819514922156015 7.72909626929227e-05 PITA -0.239099203138597 1.57096350266101e-08 NA NA NA hsa-miR-590-3p YAP1 2.59289455139753 1.03200520972022e-21 -0.819514922156015 7.72909626929227e-05 miRanda;mirMAP -0.208488993365565 6.67164473499825e-09 NA NA NA hsa-miR-590-5p YAP1 3.18300989862077 2.06813568597893e-26 -0.819514922156015 7.72909626929227e-05 MirTarget;PITA;miRanda;miRNATAP -0.199962139523476 4.08485968085029e-10 NA NA NA hsa-miR-625-5p YAP1 1.42540152147292 1.95797147911206e-06 -0.819514922156015 7.72909626929227e-05 MirTarget -0.147228805903683 5.46156978788901e-05 NA NA NA hsa-miR-7-1-3p YAP1 1.84950311431067 1.25300363397654e-13 -0.819514922156015 7.72909626929227e-05 mirMAP -0.272069114118056 1.50581196058606e-12 NA NA NA hsa-miR-708-3p YAP1 2.80907765282502 3.07460722669281e-14 -0.819514922156015 7.72909626929227e-05 mirMAP -0.131062526086185 5.45073036860843e-07 NA NA NA hsa-miR-664a-3p YES1 0.634721925861133 0.00520070178640421 0.411123055453712 0.00647633420688366 mirMAP -0.152670459336393 1.82870724650036e-06 NA NA NA