miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-let-7a-3p	KLF4	0.466622567891891	3.70886257943079e-07	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.402277174133211	1.28055406394815e-11		NA	NA	NA
hsa-let-7f-1-3p	KLF4	0.37532726250321	0.00156021688753682	-2.5658507723861	1.98241408884064e-67	MirTarget	-0.142800666732881	0.00245214885570971		NA	NA	NA
hsa-miR-103a-3p	KLF4	0.610673390034345	1.63113920514646e-12	-2.5658507723861	1.98241408884064e-67	miRNAWalker2_validate;miRTarBase	-0.371567222081179	3.47255710214153e-09		NA	NA	NA
hsa-miR-107	KLF4	0.678998026350662	2.56224148930538e-16	-2.5658507723861	1.98241408884064e-67	miRNAWalker2_validate;miRTarBase;miRanda;miRNATAP	-0.461879349672299	1.23107045223773e-12		NA	NA	NA
hsa-miR-128-3p	KLF4	0.90296715955238	9.925204823863e-23	-2.5658507723861	1.98241408884064e-67	miRNAWalker2_validate;MirTarget	-0.52709136472881	4.20620292277186e-20		NA	NA	NA
hsa-miR-142-3p	KLF4	1.53951237846104	2.06769936282034e-17	-2.5658507723861	1.98241408884064e-67	miRNATAP	-0.176398879192003	2.47910006464164e-09		NA	NA	NA
hsa-miR-148a-3p	KLF4	0.706969798912638	5.52538085480485e-09	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.203873631608458	6.02348852666786e-06		NA	NA	NA
hsa-miR-148b-3p	KLF4	1.0552576751879	1.6679285705231e-29	-2.5658507723861	1.98241408884064e-67	MirTarget	-0.572473675528514	7.0937028372698e-25		NA	NA	NA
hsa-miR-200b-3p	KLF4	2.11744072703209	1.66710572104191e-43	-2.5658507723861	1.98241408884064e-67	MirTarget;TargetScan	-0.318241517505975	1.36421966013675e-21		NA	NA	NA
hsa-miR-200c-3p	KLF4	2.07038651806183	6.84613386286599e-51	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.480814879410328	2.74192522750191e-41		NA	NA	NA
hsa-miR-25-3p	KLF4	-0.00546790775985073	0.944061771389468	-2.5658507723861	1.98241408884064e-67	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.242539392329916	0.000690131538900923		NA	NA	NA
hsa-miR-29b-3p	KLF4	0.438847962603729	6.46722433236121e-05	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.196860201179226	8.56754726528601e-05	22751119	Progestin suppression of miR 29 potentiates dedifferentiation of breast cancer cells via KLF4; We demonstrate that miR-29 directly targets Krüppel-like factor 4 KLF4 a transcription factor required for the reprogramming of differentiated cells to pluripotent stem cells and for the maintenance of breast cancer stem cells; These results reveal a novel mechanism whereby progestins increase the stem cell-like population in hormone-responsive breast cancers by decreasing miR-29 to augment PR-mediated upregulation of KLF4	differentiation	breast cancer
hsa-miR-301a-3p	KLF4	1.32170168375632	2.12280368957514e-15	-2.5658507723861	1.98241408884064e-67	miRNATAP	-0.355015910736062	3.8952855032266e-29		NA	NA	NA
hsa-miR-30b-5p	KLF4	-0.46540603860146	2.4709940429591e-05	-2.5658507723861	1.98241408884064e-67	miRNAWalker2_validate	-0.102769884205942	0.0399359934451624		NA	NA	NA
hsa-miR-32-5p	KLF4	1.38676603945192	2.29428299685976e-34	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.407529847362874	5.67291393965539e-19	26471298	We also identified Kruppel-like factor 4 KLF4 as a direct target of miR-32; We conclude that miR-32 promotes GC cell proliferation migration and invasion by targeting KLF4 suggesting that the miR-32-KLF4 pathway may be useful in clinical diagnosis and therapeutics		gastric cancer
hsa-miR-34a-5p	KLF4	0.129201805242403	0.133261654068224	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.158656084881947	0.0141218354001629		NA	NA	NA
hsa-miR-375	KLF4	2.09893673049766	1.68351780396203e-16	-2.5658507723861	1.98241408884064e-67	miRanda;miRNATAP	-0.107900770782367	3.2799038965094e-07	26224477	MiR 375 targets KLF4 and impacts the proliferation of colorectal carcinoma; Subsequently using the luciferase reporter assays we found that the KLF4 untranslated region 3'UTR carries the direct binding site of miR-375; Inhibition of KLF4 performed similar effects with miR-375 overexpression on CRC cells and overexpression of KLF4 could significantly reverse the tumor suppressive effects of miR-375 on CRC cells; Furthermore we found overexpressed miR-375 effectively repressed tumor growth via KLF4 in xenograft animal experiment; Taken together these results illustrated that miR-375 depresses proliferation of CRC through regulating 3'UTR of KLF4 mRNA which might be a promising therapeutic target for treating colorectal cancers		colorectal cancer
hsa-miR-429	KLF4	2.84108892259147	3.88520896426515e-64	-2.5658507723861	1.98241408884064e-67	MirTarget;PITA;miRanda;miRNATAP	-0.349728467927596	9.21186465368341e-33		NA	NA	NA
hsa-miR-493-5p	KLF4	1.25321217062116	2.58094342947875e-18	-2.5658507723861	1.98241408884064e-67	miRNATAP	-0.147945030318017	9.48481178556004e-05		NA	NA	NA
hsa-miR-508-3p	KLF4	0.260698649973977	0.189926238144551	-2.5658507723861	1.98241408884064e-67	PITA;miRNATAP	-0.0684979675153956	0.0143771307367952		NA	NA	NA
hsa-miR-590-3p	KLF4	1.27438512890514	1.03164723481469e-23	-2.5658507723861	1.98241408884064e-67	miRanda	-0.413516145241073	1.03039670714e-21		NA	NA	NA
hsa-miR-92a-3p	KLF4	-0.342420481092807	0.000732275969501111	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.264136295773862	1.14442585534737e-06	27131314	Additionally KLF4 was identified as a direct target of miR-92a in CRC cells through bioinformatics and luciferase reporter analysis; KLF4 overexpression attenuated the effects of miR-92a on the regulation of CRC cell motility; In conclusion our data demonstrated that miR-92a may play a positive role in the colorectal carcinogenesis by promoting the proliferation and migration of CRC cells through targeting KLF4 as well as downstream p21	motility;tumorigenesis	colorectal cancer
hsa-miR-92b-3p	KLF4	1.30248132773644	9.42428674470985e-25	-2.5658507723861	1.98241408884064e-67	MirTarget;miRNATAP	-0.264631807550341	2.77838751418002e-10		NA	NA	NA