miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125b-5p AKT1 -0.353325281902983 0.00420243402705856 0.0721339190417796 0.424327443590431 miRNAWalker2_validate;miRTarBase -0.100459272859173 0.00716650700767734 NA NA NA hsa-let-7a-5p AKT2 -0.644221394537031 9.97672106245846e-14 0.645953240953691 7.24491292520532e-10 TargetScan -0.325558448319299 1.16100918122902e-07 NA NA NA hsa-let-7b-3p AKT2 -0.39527315467518 0.0023287663817318 0.645953240953691 7.24491292520532e-10 MirTarget -0.107225704318437 0.0112102280498726 NA NA NA hsa-let-7f-1-3p AKT2 0.0152174523424196 0.909387255829372 0.645953240953691 7.24491292520532e-10 MirTarget -0.104816092335558 0.0113530152426879 NA NA NA hsa-miR-140-5p AKT2 -0.615965395622439 1.05820583250804e-08 0.645953240953691 7.24491292520532e-10 mirMAP -0.105418734672441 0.0368758234409755 NA NA NA hsa-miR-1976 AKT2 -1.13975694972151 3.52774818586224e-19 0.645953240953691 7.24491292520532e-10 miRNATAP -0.105809972429573 0.0101626337720189 NA NA NA hsa-miR-22-3p AKT2 -0.486526749940147 3.92692726571387e-08 0.645953240953691 7.24491292520532e-10 mirMAP -0.193042130263564 0.00177241098133704 NA NA NA hsa-miR-29a-3p AKT2 -1.03082784302378 5.4721714495133e-16 0.645953240953691 7.24491292520532e-10 MirTarget -0.12641428574918 0.00232257281474692 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-30e-3p AKT2 -0.568615785445122 1.6997540158547e-07 0.645953240953691 7.24491292520532e-10 mirMAP -0.117718563023673 0.0188811558797638 NA NA NA hsa-miR-106b-5p AKT3 0.768146314773296 1.22330832259683e-08 -1.05447921660024 3.75637265616143e-06 miRNATAP -0.301389292058103 0.000465450318289707 NA NA NA hsa-miR-15b-5p AKT3 0.575042920336974 9.75508983626876e-06 -1.05447921660024 3.75637265616143e-06 miRNATAP -0.226851831866612 0.0121792581274468 NA NA NA hsa-miR-17-5p AKT3 1.27106228457264 5.91314767482551e-14 -1.05447921660024 3.75637265616143e-06 TargetScan;miRNATAP -0.175691599259416 0.00930511552055326 NA NA NA hsa-miR-362-5p AKT3 0.26329593259106 0.182949931130249 -1.05447921660024 3.75637265616143e-06 PITA;TargetScan;miRNATAP -0.155920596929437 0.00915537294326056 NA NA NA hsa-miR-421 AKT3 1.16807936195133 1.4164941985739e-11 -1.05447921660024 3.75637265616143e-06 miRanda;mirMAP -0.280134678184698 2.50320739137585e-05 NA NA NA hsa-miR-424-5p AKT3 1.50572404087407 4.24425395615445e-20 -1.05447921660024 3.75637265616143e-06 miRNATAP -0.164800414805031 0.0162265723060738 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-502-5p AKT3 0.377628422695461 0.0852209444874845 -1.05447921660024 3.75637265616143e-06 PITA;miRNATAP -0.167299505709477 0.0024413620626846 NA NA NA hsa-miR-505-3p AKT3 1.02991829785126 3.27959895590399e-13 -1.05447921660024 3.75637265616143e-06 mirMAP -0.171810835894074 0.0347063613473354 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548v AKT3 1.38314663277825 1.32637772795382e-09 -1.05447921660024 3.75637265616143e-06 miRNATAP -0.211188007705888 9.85577105543065e-05 NA NA NA hsa-miR-616-5p AKT3 2.3596511369846 3.26881700557061e-22 -1.05447921660024 3.75637265616143e-06 mirMAP -0.177597274512269 0.000156306606044606 NA NA NA hsa-miR-93-5p AKT3 1.27151657903037 1.96654008726155e-14 -1.05447921660024 3.75637265616143e-06 miRNATAP -0.183065732157543 0.0077246673495683 NA NA NA hsa-miR-129-5p ANGPT1 2.0409652261565 1.19491474689015e-07 -3.63862089043794 3.33028350717528e-41 miRanda;mirMAP -0.155897567765712 7.21848187403433e-05 NA NA NA hsa-miR-429 ANGPT1 1.44127712764248 1.7824212712414e-11 -3.63862089043794 3.33028350717528e-41 miRanda -0.360476328372544 2.07695897671328e-07 NA NA NA hsa-miR-590-3p ANGPT1 0.9225805269779 6.0121446263776e-11 -3.63862089043794 3.33028350717528e-41 PITA;miRanda;mirMAP -0.62580250525878 3.37481191864788e-09 NA NA NA hsa-miR-944 ANGPT1 6.31318502943581 6.64615435406088e-56 -3.63862089043794 3.33028350717528e-41 PITA;mirMAP -0.351120684729347 2.38701101639868e-30 NA NA NA hsa-miR-186-5p ANGPT2 0.439819047090102 6.33375570167175e-05 -0.310677426542264 0.102367370075176 MirTarget;mirMAP -0.209420999409693 0.018309482587887 NA NA NA hsa-miR-19a-3p ANGPT2 1.29022522620563 7.13786738838458e-11 -0.310677426542264 0.102367370075176 MirTarget -0.140411839949015 0.00335134056033907 NA NA NA hsa-miR-19b-3p ANGPT2 0.786722036548617 1.29623163115342e-06 -0.310677426542264 0.102367370075176 MirTarget -0.178167244173187 0.00258680231051973 NA NA NA hsa-miR-33a-3p ANGPT2 0.540032749009224 0.00270907254062352 -0.310677426542264 0.102367370075176 mirMAP -0.109295471049885 0.045439496764526 NA NA NA hsa-miR-374a-5p ANGPT2 -0.371522195407694 3.64288279697975e-05 -0.310677426542264 0.102367370075176 mirMAP -0.291150398900691 0.00761755299866554 NA NA NA hsa-miR-374b-5p ANGPT2 -0.490675710652087 1.35508117735881e-06 -0.310677426542264 0.102367370075176 mirMAP -0.333287388278131 0.000480815134359266 NA NA NA hsa-miR-429 ANGPT2 1.44127712764248 1.7824212712414e-11 -0.310677426542264 0.102367370075176 miRanda -0.116680292308271 0.00820350777040053 NA NA NA hsa-miR-576-5p ANGPT2 0.993748428316612 2.24066125794743e-10 -0.310677426542264 0.102367370075176 mirMAP -0.141210426232364 0.0203381857655893 NA NA NA hsa-miR-582-5p ANGPT2 -0.0134667168827214 0.939685711149187 -0.310677426542264 0.102367370075176 mirMAP -0.115698447176493 0.0352314640661385 NA NA NA hsa-miR-590-3p ANGPT2 0.9225805269779 6.0121446263776e-11 -0.310677426542264 0.102367370075176 miRanda -0.146467753127012 0.0306262371325866 NA NA NA hsa-miR-628-3p ANGPT2 0.96307364947779 2.68891601773546e-06 -0.310677426542264 0.102367370075176 mirMAP -0.193772541931844 6.1590758779226e-05 NA NA NA hsa-miR-140-3p ATF2 -1.5688188604984 7.06409475976727e-33 0.0338545233459948 0.683561575278573 MirTarget;PITA;miRNATAP -0.125522898266886 1.85824886625016e-05 NA NA NA hsa-miR-15a-5p ATF2 -0.24629041301676 0.0253630661893983 0.0338545233459948 0.683561575278573 miRNAWalker2_validate -0.154326297105838 5.93336420421395e-05 NA NA NA hsa-miR-26a-5p ATF2 -0.929312251092796 7.48452512025337e-23 0.0338545233459948 0.683561575278573 MirTarget;miRNATAP -0.15085310397303 0.000388015754612032 NA NA NA hsa-miR-26b-5p ATF2 -0.0183893267106221 0.882303333465809 0.0338545233459948 0.683561575278573 MirTarget;miRNATAP -0.123478871174912 0.000300053831873802 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-30b-5p ATF2 -1.50117013761001 1.78247435398346e-20 0.0338545233459948 0.683561575278573 mirMAP -0.128948135630661 1.29964047604206e-07 NA NA NA hsa-miR-30c-5p ATF2 -0.426804145561029 0.00403132854321475 0.0338545233459948 0.683561575278573 mirMAP -0.103453996548012 0.000259284068729914 NA NA NA hsa-miR-374b-5p ATF2 -0.490675710652087 1.35508117735881e-06 0.0338545233459948 0.683561575278573 miRNAWalker2_validate;mirMAP;miRNATAP -0.105401309500362 0.0111953188605059 NA NA NA hsa-miR-21-5p BCL2 1.07034578283768 3.39448630342548e-28 -0.126135647413249 0.581743513504493 miRNAWalker2_validate;miRTarBase -0.47415323206419 2.39929545962589e-05 22964582;21468550;25994220;25381586;26555418;23359184;21376256 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance lung cancer;bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;pancreatic cancer hsa-miR-24-2-5p BCL2 0.712627789969659 1.71500628519945e-07 -0.126135647413249 0.581743513504493 miRNAWalker2_validate;miRTarBase -0.26782431801189 0.00157978694853124 NA NA NA hsa-miR-29a-3p BCL2 -1.03082784302378 5.4721714495133e-16 -0.126135647413249 0.581743513504493 miRNAWalker2_validate;miRTarBase -0.188409566994976 0.0342735918783788 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29a-5p BCL2 0.140889123110504 0.311453338790787 -0.126135647413249 0.581743513504493 mirMAP -0.181503312441318 0.0324492885594003 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 -0.963317497666877 0.000100334146005009 -0.126135647413249 0.581743513504493 mirMAP -0.150874367565253 0.00136328419109288 NA NA NA hsa-miR-365a-3p BCL2 0.7862881358373 2.45551602711245e-07 -0.126135647413249 0.581743513504493 miRNAWalker2_validate;miRTarBase -0.414966433417085 2.77568109663919e-08 NA NA NA hsa-miR-409-3p BCL2 1.50279965466975 5.59874611887893e-12 -0.126135647413249 0.581743513504493 mirMAP -0.189934694018372 0.000250117121717451 NA NA NA hsa-miR-582-5p BCL2 -0.0134667168827214 0.939685711149187 -0.126135647413249 0.581743513504493 PITA -0.189474419247762 0.00404303891921143 NA NA NA hsa-miR-7-5p BCL2 2.15398885914606 3.95055061525106e-16 -0.126135647413249 0.581743513504493 miRNAWalker2_validate;miRTarBase;mirMAP -0.109081309456445 0.0166688626627517 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-let-7i-5p BCL2L1 0.140484500715033 0.0901764941286614 -0.408858127085624 0.000126763112466199 miRNATAP -0.230951626138474 0.000620919440329296 NA NA NA hsa-miR-23b-3p BCL2L1 -0.29894784290965 0.00432754479018749 -0.408858127085624 0.000126763112466199 miRNAWalker2_validate -0.174779852874476 0.0009093797066115 NA NA NA hsa-miR-342-5p BCL2L1 0.0539558901968578 0.673491296758105 -0.408858127085624 0.000126763112466199 miRNATAP -0.118006866736005 0.00630327046006167 NA NA NA hsa-miR-140-5p BCL2L11 -0.615965395622439 1.05820583250804e-08 0.766196605982936 1.12073176758371e-15 miRanda -0.129967671178238 0.00539740577099704 NA NA NA hsa-miR-195-5p BCL2L11 -1.62452829530841 2.94084397454942e-29 0.766196605982936 1.12073176758371e-15 miRNAWalker2_validate -0.112110469691903 0.000546507193796539 NA NA NA hsa-miR-221-3p BCL2L11 -0.38281209626394 0.00382602010056484 0.766196605982936 1.12073176758371e-15 miRNAWalker2_validate -0.140303526957409 0.00024597735822983 26503209 Knockdown of miR 221 promotes the cisplatin inducing apoptosis by targeting the BIM Bax/Bak axis in breast cancer breast cancer hsa-miR-3065-5p BCL2L11 -0.963317497666877 0.000100334146005009 0.766196605982936 1.12073176758371e-15 mirMAP -0.10562637326393 1.70983968790786e-07 NA NA NA hsa-miR-30a-5p BCL2L11 -2.98793938555326 1.93840183838367e-49 0.766196605982936 1.12073176758371e-15 miRNATAP -0.141003372831945 4.5951081285108e-11 NA NA NA hsa-miR-30b-5p BCL2L11 -1.50117013761001 1.78247435398346e-20 0.766196605982936 1.12073176758371e-15 miRNATAP -0.172640875307375 3.55202307475319e-09 NA NA NA hsa-miR-30d-5p BCL2L11 -2.06908130936031 2.23574479943606e-47 0.766196605982936 1.12073176758371e-15 miRNATAP -0.189674783356229 5.90981643617542e-10 NA NA NA hsa-miR-338-5p BCL2L11 -2.99778534642888 2.74111905046628e-39 0.766196605982936 1.12073176758371e-15 PITA -0.115522428836321 4.45404828014841e-09 NA NA NA hsa-miR-136-5p BDNF 1.45407366758626 1.13186286039924e-12 -1.92415278230676 2.64139232765445e-09 mirMAP -0.233737299272482 0.00352822420480549 NA NA NA hsa-miR-155-5p BDNF 0.459859353454849 0.00515473360914761 -1.92415278230676 2.64139232765445e-09 miRNATAP -0.312181479826027 0.00234823953392122 NA NA NA hsa-miR-191-5p BDNF 0.870810143509924 2.16722229174023e-12 -1.92415278230676 2.64139232765445e-09 miRNATAP -0.477657036811315 0.000320326047787342 NA NA NA hsa-miR-210-3p BDNF 4.69000861651894 7.31350086152822e-67 -1.92415278230676 2.64139232765445e-09 miRNAWalker2_validate;miRTarBase -0.175074959755433 0.000711243914295183 NA NA NA hsa-miR-29b-1-5p BDNF 0.589580770665507 0.000377984052129227 -1.92415278230676 2.64139232765445e-09 mirMAP -0.295994334486807 0.00352263811248854 NA NA NA hsa-miR-330-3p BDNF 0.00879260240870505 0.951284239507664 -1.92415278230676 2.64139232765445e-09 MirTarget -0.328801095821487 0.00540298347050054 NA NA NA hsa-miR-382-5p BDNF 0.800598266897576 4.67950381504644e-05 -1.92415278230676 2.64139232765445e-09 MirTarget;miRNATAP -0.216989601224869 0.0110593111205946 NA NA NA hsa-miR-3913-5p BDNF -0.204552406283694 0.152259141583586 -1.92415278230676 2.64139232765445e-09 mirMAP -0.342636744148191 0.00416249372206317 NA NA NA hsa-miR-424-5p BDNF 1.50572404087407 4.24425395615445e-20 -1.92415278230676 2.64139232765445e-09 MirTarget;miRNATAP -0.369440045136945 0.000152924717358563 NA NA NA hsa-miR-589-3p BDNF 1.64129600791754 3.03909323325799e-16 -1.92415278230676 2.64139232765445e-09 MirTarget -0.271075352531463 0.000804794644752011 NA NA NA hsa-miR-7-1-3p BDNF 1.23074353429962 9.62692371802457e-18 -1.92415278230676 2.64139232765445e-09 MirTarget -0.228970454819658 0.0432388932703178 NA NA NA hsa-miR-125a-3p BRCA1 -0.490390905488357 0.00628500185334301 1.94964367230834 4.81768859293294e-35 MirTarget;PITA;miRanda;miRNATAP -0.249049683058088 3.59422009008504e-07 27693788 From a mechanistic standpoint hsa-miR-125a-3p directly targeted 3'-untranslated regions 3'-UTRs of breast cancer early onset gene 1 BRCA1 and inhibits its protein expression via translational repression mechanism; In addition suppression of BRCA1 expression by siRNA treatment effectively improved hsa-miR-125a-3p deficiency-triggered chemoresistance in BCa cells; Collectively these findings suggest that hsa-miR-125a-3p may function as a tumor suppressor by regulating the BRCA1 signaling and reintroduction of hsa-miR-125a-3p analogs could be a potential adjunct therapy for advanced/chemoresistant BCa drug resistance;staging breast cancer hsa-miR-146b-5p BRCA1 -0.432155779449763 0.00591587599739451 1.94964367230834 4.81768859293294e-35 miRanda -0.191131069281997 0.000701251233630424 21472990 We report here the involvement of miR-146a and miR-146b-5p that bind to the same site in the 3'UTR of BRCA1 and down-regulate its expression as demonstrated using reporter assays; Furthermore we showed that the highest levels of miR-146a and/or miR-146b-5p are found in basal-like mammary tumour epithelial cell lines and in triple negative breast tumours which are the closest to tumours arising in carriers of BRCA1 mutations breast cancer hsa-miR-181a-5p BRCA1 -1.31879909071317 2.04570351303734e-24 1.94964367230834 4.81768859293294e-35 miRNAWalker2_validate -0.497541410581112 1.50963555790586e-15 NA NA NA hsa-miR-199a-5p BRCA1 0.125189495212204 0.398433974759894 1.94964367230834 4.81768859293294e-35 miRanda -0.212726069399084 0.000392860664036246 NA NA NA hsa-miR-199b-5p BRCA1 -0.116511382952145 0.446612289886567 1.94964367230834 4.81768859293294e-35 miRanda -0.22836024343949 8.19047423810882e-05 NA NA NA hsa-miR-34c-5p BRCA1 -1.65096032312419 3.10893885639741e-06 1.94964367230834 4.81768859293294e-35 miRanda -0.137092159796449 1.70700144237663e-08 NA NA NA hsa-miR-99b-3p BRCA1 -0.260140699290343 0.124097065961821 1.94964367230834 4.81768859293294e-35 miRNAWalker2_validate -0.178814517830731 0.000653924003926238 NA NA NA hsa-let-7g-5p CCND1 0.0868874053614963 0.322163222422263 -0.638561112180978 0.010312986231343 miRNATAP -0.407906320961959 0.00605555399553983 NA NA NA hsa-miR-106a-5p CCND1 0.887689359198128 2.74215376899957e-05 -0.638561112180978 0.010312986231343 MirTarget;miRNATAP -0.216093566782229 0.000282600262956479 NA NA NA hsa-miR-106b-5p CCND1 0.768146314773296 1.22330832259683e-08 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.318797038473336 0.00062068019641174 NA NA NA hsa-miR-15b-5p CCND1 0.575042920336974 9.75508983626876e-06 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.242971732835124 0.0130310959807143 NA NA NA hsa-miR-17-5p CCND1 1.27106228457264 5.91314767482551e-14 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.232887079198658 0.0013970320785205 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-183-5p CCND1 2.81472476144496 4.67808720273896e-39 -0.638561112180978 0.010312986231343 miRNAWalker2_validate -0.236417503914316 7.78050855842189e-06 NA NA NA hsa-miR-186-5p CCND1 0.439819047090102 6.33375570167175e-05 -0.638561112180978 0.010312986231343 mirMAP -0.348282512039475 0.00274234189754363 NA NA NA hsa-miR-19a-3p CCND1 1.29022522620563 7.13786738838458e-11 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;miRTarBase;miRNATAP -0.179168374072474 0.00436970408778793 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-3p CCND1 0.786722036548617 1.29623163115342e-06 -0.638561112180978 0.010312986231343 miRNATAP -0.204998883044695 0.00836982632210324 NA NA NA hsa-miR-20a-5p CCND1 0.758237786270513 3.11867983980517e-05 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.160622719138833 0.0211248427391844 NA NA NA hsa-miR-20b-5p CCND1 0.396943783991848 0.194012869265072 -0.638561112180978 0.010312986231343 MirTarget;miRNATAP -0.134186819497774 0.00127043424210482 NA NA NA hsa-miR-340-5p CCND1 0.172446891226333 0.176440862972852 -0.638561112180978 0.010312986231343 mirMAP -0.341690667147615 0.000683220659162304 NA NA NA hsa-miR-374b-5p CCND1 -0.490675710652087 1.35508117735881e-06 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;MirTarget -0.252155979490174 0.0453950575452417 NA NA NA hsa-miR-425-5p CCND1 0.85235119766839 8.55415485589217e-07 -0.638561112180978 0.010312986231343 miRNAWalker2_validate -0.329298506417729 5.11883715830385e-06 NA NA NA hsa-miR-503-5p CCND1 2.44514033793504 1.41589743344165e-28 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;miRTarBase;MirTarget -0.108681588673421 0.0433551849249386 26047605;23731275 MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC ;progression;tumorigenesis breast cancer;endometrial cancer hsa-miR-589-3p CCND1 1.64129600791754 3.03909323325799e-16 -0.638561112180978 0.010312986231343 MirTarget -0.216890159065809 0.000381944267637448 NA NA NA hsa-miR-590-3p CCND1 0.9225805269779 6.0121446263776e-11 -0.638561112180978 0.010312986231343 mirMAP -0.290398408271701 0.00104606382537959 NA NA NA hsa-miR-7-1-3p CCND1 1.23074353429962 9.62692371802457e-18 -0.638561112180978 0.010312986231343 mirMAP -0.217917426534086 0.0107573931062147 NA NA NA hsa-miR-769-3p CCND1 1.69905535351918 1.30902489673511e-18 -0.638561112180978 0.010312986231343 mirMAP -0.294734968727479 2.47312660139328e-06 NA NA NA hsa-miR-9-5p CCND1 4.97757576742384 8.49748323724349e-41 -0.638561112180978 0.010312986231343 miRNAWalker2_validate -0.138926681647076 4.73864055233326e-06 NA NA NA hsa-miR-93-5p CCND1 1.27151657903037 1.96654008726155e-14 -0.638561112180978 0.010312986231343 miRNAWalker2_validate;MirTarget;miRNATAP -0.248233938032105 0.000809256740236948 NA NA NA hsa-miR-942-5p CCND1 0.707804935292199 1.66243149466953e-05 -0.638561112180978 0.010312986231343 MirTarget -0.180045881557002 0.019669114007287 NA NA NA hsa-miR-141-3p CCND2 1.96958415696982 1.4648441542521e-24 -0.695647412690433 0.0160934462317537 MirTarget;TargetScan -0.144441702591589 0.0457880023149446 NA NA NA hsa-miR-17-5p CCND2 1.27106228457264 5.91314767482551e-14 -0.695647412690433 0.0160934462317537 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.20413429661905 0.0161295370364412 NA NA NA hsa-miR-19a-3p CCND2 1.29022522620563 7.13786738838458e-11 -0.695647412690433 0.0160934462317537 MirTarget;miRNATAP -0.167804813810776 0.0217053765060143 NA NA NA hsa-miR-20a-5p CCND2 0.758237786270513 3.11867983980517e-05 -0.695647412690433 0.0160934462317537 miRNAWalker2_validate;miRTarBase;miRNATAP -0.226588295204601 0.00499899554716558 NA NA NA hsa-miR-21-3p CCND2 0.924068840797428 6.92652443457631e-12 -0.695647412690433 0.0160934462317537 mirMAP -0.314769632505486 0.0033852342653759 NA NA NA hsa-miR-301a-3p CCND2 1.23940945645189 2.05328421457283e-11 -0.695647412690433 0.0160934462317537 miRNAWalker2_validate -0.199323485566078 0.0107220216198258 NA NA NA hsa-miR-550a-5p CCND2 0.762494609455337 2.22125274981609e-05 -0.695647412690433 0.0160934462317537 MirTarget -0.183042112944571 0.0253879175730306 NA NA NA hsa-miR-589-3p CCND2 1.64129600791754 3.03909323325799e-16 -0.695647412690433 0.0160934462317537 mirMAP -0.217855805603576 0.0021580217660884 NA NA NA hsa-miR-590-5p CCND2 1.22823897140696 7.5538778278798e-17 -0.695647412690433 0.0160934462317537 mirMAP -0.253069737516668 0.00892627347294773 NA NA NA hsa-miR-616-5p CCND2 2.3596511369846 3.26881700557061e-22 -0.695647412690433 0.0160934462317537 mirMAP -0.138307393404591 0.0196846282810926 NA NA NA hsa-miR-7-1-3p CCND2 1.23074353429962 9.62692371802457e-18 -0.695647412690433 0.0160934462317537 mirMAP -0.237974973928116 0.0164657209861754 NA NA NA hsa-miR-877-5p CCND2 2.90093737151303 2.52134268016683e-35 -0.695647412690433 0.0160934462317537 miRNAWalker2_validate -0.141705302537856 0.0158007509602993 NA NA NA hsa-miR-15b-5p CCND3 0.575042920336974 9.75508983626876e-06 -1.55298224027458 4.45184112141735e-29 miRNATAP -0.182015857438503 0.00190764290626009 NA NA NA hsa-miR-27b-3p CCND3 0.0774984459252845 0.455541249499373 -1.55298224027458 4.45184112141735e-29 miRNAWalker2_validate -0.26274944752798 0.000433821214589318 NA NA NA hsa-miR-28-5p CCND3 0.189534080376749 0.0278108067630943 -1.55298224027458 4.45184112141735e-29 miRNATAP -0.246667236685659 0.00657842149257221 NA NA NA hsa-miR-320b CCND3 1.16387990475466 1.33051259463572e-10 -1.55298224027458 4.45184112141735e-29 miRanda -0.147920127729639 0.000328634292183438 NA NA NA hsa-miR-324-5p CCND3 1.21634042749489 1.07503319022833e-13 -1.55298224027458 4.45184112141735e-29 miRNAWalker2_validate -0.224218972584674 5.84663038195843e-07 NA NA NA hsa-miR-409-5p CCND3 1.56313058399388 3.56381656647118e-12 -1.55298224027458 4.45184112141735e-29 miRNATAP -0.169254394107169 2.32367825961937e-07 NA NA NA hsa-miR-421 CCND3 1.16807936195133 1.4164941985739e-11 -1.55298224027458 4.45184112141735e-29 PITA;miRanda -0.133091686851952 0.00216641981417282 NA NA NA hsa-miR-424-5p CCND3 1.50572404087407 4.24425395615445e-20 -1.55298224027458 4.45184112141735e-29 miRNAWalker2_validate;miRTarBase -0.175677272803885 7.12845705853172e-05 NA NA NA hsa-miR-429 CCND3 1.44127712764248 1.7824212712414e-11 -1.55298224027458 4.45184112141735e-29 miRNATAP -0.198720678833265 6.19657876890127e-09 NA NA NA hsa-miR-454-3p CCND3 0.942883363058312 9.73843658862518e-10 -1.55298224027458 4.45184112141735e-29 miRNATAP -0.160800271025144 0.000953287530046259 NA NA NA hsa-miR-940 CCND3 1.91696621517233 1.3556247816872e-17 -1.55298224027458 4.45184112141735e-29 MirTarget;miRNATAP -0.191520279541127 2.47802056006156e-09 NA NA NA hsa-miR-96-5p CCND3 2.81159638603625 3.72452637775194e-34 -1.55298224027458 4.45184112141735e-29 TargetScan -0.225113676285011 1.46714560687876e-14 NA NA NA hsa-miR-125b-5p CCNE1 -0.353325281902983 0.00420243402705856 3.9201860386259 6.26445216089632e-70 miRNAWalker2_validate -0.582686820413106 1.22348799065135e-07 NA NA NA hsa-miR-138-5p CCNE1 -1.36574941930317 5.77867420411166e-08 3.9201860386259 6.26445216089632e-70 MirTarget;miRNATAP -0.312940756306502 3.34731901841127e-09 NA NA NA hsa-miR-195-5p CCNE1 -1.62452829530841 2.94084397454942e-29 3.9201860386259 6.26445216089632e-70 miRNAWalker2_validate;MirTarget;miRNATAP -0.918892771742224 1.69856932097834e-29 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.929312251092796 7.48452512025337e-23 3.9201860386259 6.26445216089632e-70 miRNAWalker2_validate;miRTarBase;miRNATAP -1.32240007379792 3.96909300229671e-24 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -1.37093122385312 2.06413037457593e-23 3.9201860386259 6.26445216089632e-70 MirTarget;miRNATAP -0.873220778540677 9.68603298008075e-23 25909221;24112607;24909281 The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; lung cancer;breast cancer;cervical and endocervical cancer hsa-let-7b-3p CCNE2 -0.39527315467518 0.0023287663817318 2.5333354570074 1.09448516601265e-46 mirMAP -0.298285211385229 0.000155454527049645 NA NA NA hsa-miR-126-3p CCNE2 -1.52720963398862 2.32531989121959e-20 2.5333354570074 1.09448516601265e-46 miRNAWalker2_validate -0.414032287610378 5.0967980955793e-13 NA NA NA hsa-miR-140-5p CCNE2 -0.615965395622439 1.05820583250804e-08 2.5333354570074 1.09448516601265e-46 miRanda -0.49992300429152 8.13204672261463e-08 NA NA NA hsa-miR-26a-5p CCNE2 -0.929312251092796 7.48452512025337e-23 2.5333354570074 1.09448516601265e-46 miRNAWalker2_validate;miRTarBase;miRNATAP -0.94109291089571 1.00129790021921e-21 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-3065-5p CCNE2 -0.963317497666877 0.000100334146005009 2.5333354570074 1.09448516601265e-46 mirMAP -0.118917166741088 0.00405843451283862 NA NA NA hsa-miR-30a-5p CCNE2 -2.98793938555326 1.93840183838367e-49 2.5333354570074 1.09448516601265e-46 miRNATAP -0.529976658131441 2.07095508098977e-40 NA NA NA hsa-miR-30b-5p CCNE2 -1.50117013761001 1.78247435398346e-20 2.5333354570074 1.09448516601265e-46 miRNAWalker2_validate;miRTarBase -0.390071510337319 3.27662905978012e-11 22384020 A luciferase-based reporter assay demonstrated that miR-30b post-transcriptionally reduced 27% p = 0.005 of the gene expression by interacting with two binding sites in the 3'-UTR of CCNE2; The upregulation of miR-30b by trastuzumab may play a biological role in trastuzumab-induced cell growth inhibition by targeting CCNE2 breast cancer hsa-miR-30c-5p CCNE2 -0.426804145561029 0.00403132854321475 2.5333354570074 1.09448516601265e-46 miRNATAP -0.20552146602653 0.00293769343339266 NA NA NA hsa-miR-30d-5p CCNE2 -2.06908130936031 2.23574479943606e-47 2.5333354570074 1.09448516601265e-46 miRNATAP -0.535281435506885 7.51657710990676e-19 25843294 MicroRNA 30d 5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non small cell lung cancer; In addition the re-introduction of CCNE2 expression antagonised the inhibitory effects of miR-30d-5p on the capacity of NSCLC cells for proliferation and motility motility lung squamous cell cancer hsa-miR-34a-5p CCNE2 -0.43794334019748 0.000117590706048968 2.5333354570074 1.09448516601265e-46 miRNAWalker2_validate;miRTarBase;miRNATAP -0.277619988193707 0.00210560899016084 NA NA NA hsa-miR-34b-5p CCNE2 -1.07161917037086 0.00215516116448498 2.5333354570074 1.09448516601265e-46 miRNAWalker2_validate;miRTarBase -0.112501120169484 0.000157945146403846 NA NA NA hsa-miR-34c-5p CCNE2 -1.65096032312419 3.10893885639741e-06 2.5333354570074 1.09448516601265e-46 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.143156059470821 3.87133556637501e-07 NA NA NA hsa-miR-140-5p CDK2 -0.615965395622439 1.05820583250804e-08 0.969954872518406 2.46790727076419e-23 miRanda -0.251056725763398 1.76615538893036e-07 NA NA NA hsa-miR-145-5p CDK4 -1.08109692150888 5.28948625689113e-14 1.33802877407597 3.55646464887129e-39 miRNAWalker2_validate;miRTarBase -0.280429973399427 1.54006195967533e-13 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-195-5p CDK4 -1.62452829530841 2.94084397454942e-29 1.33802877407597 3.55646464887129e-39 miRNAWalker2_validate;miRTarBase -0.314379691905663 8.98750861849959e-19 NA NA NA hsa-miR-34a-5p CDK4 -0.43794334019748 0.000117590706048968 1.33802877407597 3.55646464887129e-39 miRNAWalker2_validate;miRTarBase -0.205261795750941 5.37674234950463e-05 25789847 Real-time PCR and western blot analysis of extracted RNA and total protein revealed artemsinin and artesunate increased miR-34a expression in a dose-dependent manner correlating with down-regulation of the miR-34a target gene CDK4; Phytochemical treatments inhibited the luciferase activity of a construct containing the wild-type 3'UTR of CDK4 but not those with a mutated miR-34a binding site whereas transfection of miR-34a inhibitors ablated the phytochemical mediated down-regulation of CDK4 and induction of cell cycle arrest breast cancer hsa-miR-486-5p CDK4 -3.31030668897609 1.04617579408648e-33 1.33802877407597 3.55646464887129e-39 miRanda;miRNATAP -0.150787228392162 5.35967237657346e-16 27049724 Direct repression of the oncogene CDK4 by the tumor suppressor miR 486 5p in non small cell lung cancer; Additionally we showed that CDK4 an oncogene that plays an important role in cell cycle G1/S phase progression was directly targeted by miR-486-5p; Collectively our results suggest that miR-486-5p could not only inhibit NSCLC by downregulating the expression of CDK4 but also be as a promising and potent therapy in the near future progression lung squamous cell cancer hsa-miR-101-3p CDK6 -2.01992291103908 2.62945171087274e-42 1.05503772402536 2.30120470767778e-10 mirMAP -0.300498934928208 6.12839896150669e-09 NA NA NA hsa-miR-107 CDK6 -0.456345046928702 5.29231946717953e-06 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.184048499088819 0.0351001343677032 19407485;22491216;21264532;19688090 Enforced expression of miR-107 in MiaPACA-2 and PANC-1 cells downregulated in vitro growth and this was associated with repression of the putative miR-107 target cyclin-dependent kinase 6 thereby providing a functional basis for the epigenetic inactivation of this miRNA in pancreatic cancer;Levels of known miR-107 targets protein kinase Cε PKCε cyclin-dependent kinase 6 CDK6 and hypoxia-inducible factor 1-β HIF1-β decreased following NP/pre-miR-107 treatment;We have identified miR-107 as a potential regulator of CDK6 expression; A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3' untranslated region; Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression; miR-107 could significantly suppress CDK6 3' UTR luciferase reporter activity and this effect was not detectable when the putative 3' UTR target site was mutated; Consistent with the results of the reporter assay ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 inhibited proliferation induced G1 cell cycle arrest and blocked invasion of the gastric cancer cells; Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells;Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 ;;; pancreatic cancer;head and neck cancer;gastric cancer;lung squamous cell cancer hsa-miR-140-3p CDK6 -1.5688188604984 7.06409475976727e-33 1.05503772402536 2.30120470767778e-10 miRNATAP -0.321297308453502 9.46985682201605e-08 NA NA NA hsa-miR-142-5p CDK6 -0.0363288420100352 0.821716201807163 1.05503772402536 2.30120470767778e-10 PITA -0.171606927276645 0.00155703026807021 NA NA NA hsa-miR-145-3p CDK6 -1.41475926107847 2.20187227373045e-21 1.05503772402536 2.30120470767778e-10 mirMAP -0.113279193208473 0.0417277343692348 24510775 miR 145 sensitizes ovarian cancer cells to paclitaxel by targeting Sp1 and Cdk6; In our study paclitaxel-resistant ovarian cancer patients and cell lines had decreased miR-145 levels and expressed high levels of Sp1 and Cdk6; Furthermore we confirmed that both Cdk6 and Sp1 are targets of miR-145; Collectively these findings begin to elucidate the role of miR-145 as an important regulator of chemoresistance in ovarian cancer by controlling both Cdk6 and Sp1 drug resistance ovarian cancer hsa-miR-146b-5p CDK6 -0.432155779449763 0.00591587599739451 1.05503772402536 2.30120470767778e-10 mirMAP -0.18443598231752 0.000871028541582737 NA NA NA hsa-miR-148b-3p CDK6 0.0385421182152106 0.68086754032186 1.05503772402536 2.30120470767778e-10 mirMAP -0.388537897357151 3.71098662896839e-05 NA NA NA hsa-miR-15a-5p CDK6 -0.24629041301676 0.0253630661893983 1.05503772402536 2.30120470767778e-10 miRNATAP -0.20321446226762 0.0110358230548831 NA NA NA hsa-miR-16-5p CDK6 0.200674510503047 0.0593717079356147 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase -0.197526955970877 0.0172757316021653 NA NA NA hsa-miR-185-5p CDK6 0.0188696639275925 0.858581663208548 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate -0.195820852822939 0.019171338387025 19688090 Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 lung squamous cell cancer hsa-miR-195-5p CDK6 -1.62452829530841 2.94084397454942e-29 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase -0.211367902838252 0.00014603538603593 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-1976 CDK6 -1.13975694972151 3.52774818586224e-19 1.05503772402536 2.30120470767778e-10 mirMAP -0.248552352081229 0.000139410694736862 NA NA NA hsa-miR-218-5p CDK6 -1.79097768150997 1.46926601815429e-27 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate -0.163592433156048 0.000877211293756804 23996750 Ectopic expression of miR-218 in HepG2 cells resulted in suppressed cell proliferation and enhanced cell apoptosis as well as the down-regulation of Bmi-1 and CDK6 mRNA and protein expressions P<0.05; The low-expression of miR-218 is correlated with malignant clinicopathological characteristics of HCC and miR-218 may inhibit cell proliferation and promote cell apoptosis by down-regulating Bmi-1 and CDK6 in HCC malignant trasformation liver cancer hsa-miR-26a-5p CDK6 -0.929312251092796 7.48452512025337e-23 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.413453886636399 2.19369345327328e-06 26314438 Maxvision immunohistochemistry technique was used to detect the expression level of CDK6 and miR-26a in tissue of 20 ENKTCL cases 10 cases of proliferative lymphadenitis and 10 samples of normal lymph node respectively; The possible role of miR-26a and its target gene CDK6 in genesis and development of ENKTCL were analyzed according to the clinical features of ENKTCL patients; Correlation analysis showed that there was significant negative correlation between miR-26a expression and CDK6 expression r = -0.54 P = 0.04 lymphoma hsa-miR-29a-3p CDK6 -1.03082784302378 5.4721714495133e-16 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.214763235713219 0.00115342234062083 22493297;23245396;20086245 In addition a target of miR-29a cyclin-dependent kinase 6 gene and a target of miR-142-3p TGF-β-activated kinase 1/MAP3K7 binding protein 2 gene are involved in the regulation of both monocytic and granulocytic differentiation;The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL differentiation;; acute myeloid leukemia;melanoma;lymphoma hsa-miR-29b-3p CDK6 -0.0219237619606503 0.883966228726957 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.150283138874268 0.0100794044337402 23591808;23245396;25472644;26180082;27230400;20086245 Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; lung cancer;melanoma;colorectal cancer;glioblastoma;sarcoma;lymphoma hsa-miR-29c-3p CDK6 -1.50225173284958 1.90087771871443e-16 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.213634119645424 2.53173463340725e-06 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-30a-3p CDK6 -2.84775732421554 1.32356843902033e-38 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase;mirMAP -0.11158088483702 0.00179960778684008 NA NA NA hsa-miR-30a-5p CDK6 -2.98793938555326 1.93840183838367e-49 1.05503772402536 2.30120470767778e-10 mirMAP -0.179527757995349 1.48986498192401e-06 NA NA NA hsa-miR-30b-5p CDK6 -1.50117013761001 1.78247435398346e-20 1.05503772402536 2.30120470767778e-10 mirMAP -0.216702958689376 2.0046847477047e-05 NA NA NA hsa-miR-30c-5p CDK6 -0.426804145561029 0.00403132854321475 1.05503772402536 2.30120470767778e-10 mirMAP -0.147338240058866 0.0122464341458536 NA NA NA hsa-miR-30d-3p CDK6 -1.57797039577408 4.48970383848141e-24 1.05503772402536 2.30120470767778e-10 mirMAP -0.175373456919749 0.000831308182911202 NA NA NA hsa-miR-30d-5p CDK6 -2.06908130936031 2.23574479943606e-47 1.05503772402536 2.30120470767778e-10 mirMAP -0.299209236865035 1.51501794698459e-08 NA NA NA hsa-miR-30e-5p CDK6 0.186424244301373 0.077486249643257 1.05503772402536 2.30120470767778e-10 mirMAP -0.183784907966011 0.0281471127712279 NA NA NA hsa-miR-32-5p CDK6 -0.349953074737666 0.00689126382132822 1.05503772402536 2.30120470767778e-10 miRNATAP -0.296143780174886 9.97716766566207e-06 NA NA NA hsa-miR-338-3p CDK6 -2.39495045399875 3.50911311863594e-28 1.05503772402536 2.30120470767778e-10 mirMAP -0.14519368371153 8.48523542184832e-05 NA NA NA hsa-miR-34a-5p CDK6 -0.43794334019748 0.000117590706048968 1.05503772402536 2.30120470767778e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.343446919031941 6.51909785598258e-06 26104764;21702042 The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization ; lung cancer;bladder cancer hsa-miR-362-5p CDK6 0.26329593259106 0.182949931130249 1.05503772402536 2.30120470767778e-10 mirMAP -0.111384150382326 0.0116985018878257 NA NA NA hsa-miR-374a-5p CDK6 -0.371522195407694 3.64288279697975e-05 1.05503772402536 2.30120470767778e-10 mirMAP -0.406717732844883 2.82248747045659e-05 NA NA NA hsa-miR-374b-5p CDK6 -0.490675710652087 1.35508117735881e-06 1.05503772402536 2.30120470767778e-10 mirMAP -0.337655031023325 7.66015770860684e-05 NA NA NA hsa-miR-497-5p CDK6 -1.37093122385312 2.06413037457593e-23 1.05503772402536 2.30120470767778e-10 miRNATAP -0.212710573331444 0.000363959717576931 NA NA NA hsa-miR-502-3p CDK6 -0.516137549858388 4.50135190438313e-05 1.05503772402536 2.30120470767778e-10 PITA;miRNATAP -0.214639300144403 0.0017777854754328 NA NA NA hsa-miR-660-5p CDK6 -0.701465625095864 2.01633605692768e-06 1.05503772402536 2.30120470767778e-10 mirMAP -0.197053115221067 0.00073850639008673 NA NA NA hsa-let-7d-5p CDKN1A 0.0470413504723624 0.6502410569426 -0.662784166922473 1.84456100975042e-05 MirTarget -0.299420811091403 0.00011843084040234 NA NA NA hsa-let-7f-5p CDKN1A -0.247755606925729 0.0395456675844559 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;MirTarget -0.143034194353651 0.0328283601799112 NA NA NA hsa-let-7g-5p CDKN1A 0.0868874053614963 0.322163222422263 -0.662784166922473 1.84456100975042e-05 MirTarget -0.39691889293198 1.71460550414496e-05 NA NA NA hsa-miR-106a-5p CDKN1A 0.887689359198128 2.74215376899957e-05 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.282622750981092 4.86242324526781e-15 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-106b-5p CDKN1A 0.768146314773296 1.22330832259683e-08 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.438616455141055 8.01606277882527e-15 NA NA NA hsa-miR-17-5p CDKN1A 1.27106228457264 5.91314767482551e-14 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.331869698471686 6.45234878062402e-14 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-182-5p CDKN1A 2.16789823981744 5.64205069446407e-26 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate -0.25285622624904 6.96680299195007e-13 NA NA NA hsa-miR-20a-5p CDKN1A 0.758237786270513 3.11867983980517e-05 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.269946616669065 2.36028742600026e-10 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-20b-5p CDKN1A 0.396943783991848 0.194012869265072 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.167052398964733 5.7821726379769e-11 NA NA NA hsa-miR-28-5p CDKN1A 0.189534080376749 0.0278108067630943 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.48831508511848 1.68245586841225e-07 NA NA NA hsa-miR-335-5p CDKN1A -0.324086861750615 0.0899025346373434 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate -0.150004975084674 0.000321072936557771 NA NA NA hsa-miR-345-5p CDKN1A 2.15589176233429 1.27644715671951e-24 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.15396594107271 1.27696417226498e-05 NA NA NA hsa-miR-363-3p CDKN1A -0.318588561792557 0.232403434324873 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase -0.157018442196059 1.14329809867936e-07 NA NA NA hsa-miR-423-3p CDKN1A 1.28110076242996 1.865415526013e-23 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase -0.400332635005199 2.76380002242085e-12 NA NA NA hsa-miR-423-5p CDKN1A 0.427072818804231 0.0012124903743904 -0.662784166922473 1.84456100975042e-05 MirTarget -0.348905615718531 4.68708111350439e-09 NA NA NA hsa-miR-429 CDKN1A 1.44127712764248 1.7824212712414e-11 -0.662784166922473 1.84456100975042e-05 miRNATAP -0.14972333378305 3.2226724335758e-05 NA NA NA hsa-miR-503-5p CDKN1A 2.44514033793504 1.41589743344165e-28 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase -0.135727047369888 4.79779965488404e-05 NA NA NA hsa-miR-505-5p CDKN1A 1.28871267080216 1.00459615050289e-12 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;MirTarget -0.270515294927757 1.13773694637977e-10 NA NA NA hsa-miR-616-5p CDKN1A 2.3596511369846 3.26881700557061e-22 -0.662784166922473 1.84456100975042e-05 mirMAP -0.197541762274758 2.60726953980095e-10 NA NA NA hsa-miR-708-5p CDKN1A 3.70808687333578 5.51249219545358e-54 -0.662784166922473 1.84456100975042e-05 MirTarget -0.104684906077147 0.00025654524301531 NA NA NA hsa-miR-93-5p CDKN1A 1.27151657903037 1.96654008726155e-14 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.363860481468945 4.22160482324208e-16 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-942-5p CDKN1A 0.707804935292199 1.66243149466953e-05 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate -0.26411914860632 2.68621233949313e-08 NA NA NA hsa-miR-96-5p CDKN1A 2.81159638603625 3.72452637775194e-34 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;miRTarBase -0.222038820540623 4.19552443063484e-13 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-98-5p CDKN1A 0.278359437335009 0.00921227131925612 -0.662784166922473 1.84456100975042e-05 miRNAWalker2_validate;MirTarget -0.297601764371323 7.3111175082643e-05 NA NA NA hsa-miR-221-3p CDKN1B -0.38281209626394 0.00382602010056484 -0.166965968056625 0.0918024101927628 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.157034866976748 3.57689870806398e-05 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 0.650386170149202 1.83345699702669e-06 -0.166965968056625 0.0918024101927628 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.151732542960064 3.24603685046846e-05 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-24-3p CDKN1B 0.272730498465254 0.0053154135686548 -0.166965968056625 0.0918024101927628 miRNAWalker2_validate;miRNATAP -0.145157692414379 0.00541284311610032 26847530;26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p ; prostate cancer;breast cancer hsa-miR-221-5p CHAD 0.312129280210106 0.142808962347635 -0.553839948203202 0.0360538473575106 MirTarget -0.177424488481675 0.00544003979763104 NA NA NA hsa-miR-222-5p CHAD 0.0443787380374991 0.777043899241278 -0.553839948203202 0.0360538473575106 MirTarget -0.337282815913511 9.38983541944815e-05 NA NA NA hsa-miR-199a-5p CHRM1 0.125189495212204 0.398433974759894 -4.8921657096327 3.76346047135451e-36 miRanda -0.312031597815814 0.0369988123349489 NA NA NA hsa-miR-27a-3p CHRM1 0.140284703630369 0.213001086994521 -4.8921657096327 3.76346047135451e-36 miRNATAP -0.750152685430691 0.000136639697522884 NA NA NA hsa-miR-760 CHRM1 2.46800133673516 9.92808266371112e-19 -4.8921657096327 3.76346047135451e-36 mirMAP -0.258354977765129 0.000764492608159289 NA NA NA hsa-miR-940 CHRM1 1.91696621517233 1.3556247816872e-17 -4.8921657096327 3.76346047135451e-36 miRNATAP -0.278458086118379 0.00299655284811279 NA NA NA hsa-let-7a-5p COL1A1 -0.644221394537031 9.97672106245846e-14 2.37174825504427 1.4639822617261e-15 TargetScan;miRNATAP -0.410681872494015 0.0227841920691305 NA NA NA hsa-let-7d-5p COL1A1 0.0470413504723624 0.6502410569426 2.37174825504427 1.4639822617261e-15 miRNATAP -1.08235713512547 6.12699196868837e-13 NA NA NA hsa-let-7f-5p COL1A1 -0.247755606925729 0.0395456675844559 2.37174825504427 1.4639822617261e-15 miRNATAP -0.503726559809915 0.000133323884165035 NA NA NA hsa-let-7g-5p COL1A1 0.0868874053614963 0.322163222422263 2.37174825504427 1.4639822617261e-15 miRNATAP -0.802581584095194 1.12494076096547e-05 NA NA NA hsa-miR-106a-5p COL1A1 0.887689359198128 2.74215376899957e-05 2.37174825504427 1.4639822617261e-15 mirMAP -0.432925166881065 2.58710272030007e-09 NA NA NA hsa-miR-106b-5p COL1A1 0.768146314773296 1.22330832259683e-08 2.37174825504427 1.4639822617261e-15 mirMAP -0.70051543773158 6.64853945920362e-10 NA NA NA hsa-miR-107 COL1A1 -0.456345046928702 5.29231946717953e-06 2.37174825504427 1.4639822617261e-15 PITA;miRanda -0.920804313051683 3.09961006930971e-09 NA NA NA hsa-miR-126-5p COL1A1 -1.94634635849451 2.4038399235921e-37 2.37174825504427 1.4639822617261e-15 miRNATAP -0.79425034725465 9.67724796713908e-19 NA NA NA hsa-miR-133a-3p COL1A1 -2.91239323338447 8.28583105925908e-27 2.37174825504427 1.4639822617261e-15 miRNAWalker2_validate -0.235114430824488 1.33341150662358e-05 NA NA NA hsa-miR-17-5p COL1A1 1.27106228457264 5.91314767482551e-14 2.37174825504427 1.4639822617261e-15 mirMAP -0.334543530593208 0.000205195782514988 NA NA NA hsa-miR-20a-5p COL1A1 0.758237786270513 3.11867983980517e-05 2.37174825504427 1.4639822617261e-15 mirMAP -0.396433649350368 3.46057055053385e-06 NA NA NA hsa-miR-20b-5p COL1A1 0.396943783991848 0.194012869265072 2.37174825504427 1.4639822617261e-15 mirMAP -0.332107557143096 4.84066254053822e-11 NA NA NA hsa-miR-218-5p COL1A1 -1.79097768150997 1.46926601815429e-27 2.37174825504427 1.4639822617261e-15 MirTarget;miRNATAP -0.486946105048685 3.27017536492523e-08 NA NA NA hsa-miR-29a-3p COL1A1 -1.03082784302378 5.4721714495133e-16 2.37174825504427 1.4639822617261e-15 miRNATAP -0.288077628879769 0.0166573335351027 NA NA NA hsa-miR-29b-3p COL1A1 -0.0219237619606503 0.883966228726957 2.37174825504427 1.4639822617261e-15 miRNAWalker2_validate;miRTarBase;miRNATAP -0.289704995582377 0.00625258111520622 NA NA NA hsa-miR-29c-3p COL1A1 -1.50225173284958 1.90087771871443e-16 2.37174825504427 1.4639822617261e-15 miRNAWalker2_validate;miRTarBase;miRNATAP -0.259152693339597 0.00181359808910423 NA NA NA hsa-miR-30a-3p COL1A1 -2.84775732421554 1.32356843902033e-38 2.37174825504427 1.4639822617261e-15 mirMAP -0.372436131402082 5.47469021398259e-09 NA NA NA hsa-miR-30b-3p COL1A1 -0.976858856774298 4.89616633369313e-08 2.37174825504427 1.4639822617261e-15 miRNATAP -0.560909731909205 4.54164892374159e-11 NA NA NA hsa-miR-30d-3p COL1A1 -1.57797039577408 4.48970383848141e-24 2.37174825504427 1.4639822617261e-15 mirMAP -0.969133711476058 1.08525285336026e-27 NA NA NA hsa-miR-30e-3p COL1A1 -0.568615785445122 1.6997540158547e-07 2.37174825504427 1.4639822617261e-15 mirMAP -0.478308384537193 0.000931306846062166 NA NA NA hsa-miR-338-3p COL1A1 -2.39495045399875 3.50911311863594e-28 2.37174825504427 1.4639822617261e-15 miRanda;miRNATAP -0.489725124738583 6.37609052646876e-14 NA NA NA hsa-miR-361-3p COL1A1 -0.491157107537441 1.38504517485595e-06 2.37174825504427 1.4639822617261e-15 PITA -0.66987868065902 1.42534630611645e-05 NA NA NA hsa-miR-532-3p COL1A1 0.62928908928122 1.1124581803679e-05 2.37174825504427 1.4639822617261e-15 PITA;miRNATAP -0.326993100027537 0.00287987179195795 NA NA NA hsa-miR-590-3p COL1A1 0.9225805269779 6.0121446263776e-11 2.37174825504427 1.4639822617261e-15 miRanda -0.33755582807949 0.00212747901852646 NA NA NA hsa-miR-93-5p COL1A1 1.27151657903037 1.96654008726155e-14 2.37174825504427 1.4639822617261e-15 mirMAP -0.351242399180995 0.00012646010489933 NA NA NA hsa-let-7d-5p COL1A2 0.0470413504723624 0.6502410569426 0.890733647925744 0.000839239456437956 MirTarget;miRNATAP -1.01917679448094 3.67091882173151e-15 NA NA NA hsa-let-7f-5p COL1A2 -0.247755606925729 0.0395456675844559 0.890733647925744 0.000839239456437956 MirTarget;miRNATAP -0.372797178628032 0.00114860353212314 NA NA NA hsa-let-7g-5p COL1A2 0.0868874053614963 0.322163222422263 0.890733647925744 0.000839239456437956 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.748058997541306 2.25280518421802e-06 NA NA NA hsa-miR-19a-3p COL1A2 1.29022522620563 7.13786738838458e-11 0.890733647925744 0.000839239456437956 MirTarget -0.369080860151401 2.94843979423576e-08 NA NA NA hsa-miR-19b-3p COL1A2 0.786722036548617 1.29623163115342e-06 0.890733647925744 0.000839239456437956 MirTarget -0.524591493617712 1.35721911665991e-10 NA NA NA hsa-miR-25-3p COL1A2 0.324190582599831 0.0073283146172755 0.890733647925744 0.000839239456437956 MirTarget;miRNATAP -0.683702215944855 1.00801582223616e-09 NA NA NA hsa-miR-26a-5p COL1A2 -0.929312251092796 7.48452512025337e-23 0.890733647925744 0.000839239456437956 MirTarget;miRNATAP -0.279408246448872 0.0446341255930897 NA NA NA hsa-miR-26b-5p COL1A2 -0.0183893267106221 0.882303333465809 0.890733647925744 0.000839239456437956 MirTarget;miRNATAP -0.53215118755882 1.436594118251e-06 NA NA NA hsa-miR-29b-3p COL1A2 -0.0219237619606503 0.883966228726957 0.890733647925744 0.000839239456437956 miRNATAP -0.310964898070405 0.000691130787414211 NA NA NA hsa-miR-30a-3p COL1A2 -2.84775732421554 1.32356843902033e-38 0.890733647925744 0.000839239456437956 MirTarget -0.133388082861197 0.0180840865483858 NA NA NA hsa-miR-30d-3p COL1A2 -1.57797039577408 4.48970383848141e-24 0.890733647925744 0.000839239456437956 MirTarget -0.708305601935257 2.99277124995432e-19 NA NA NA hsa-miR-32-5p COL1A2 -0.349953074737666 0.00689126382132822 0.890733647925744 0.000839239456437956 MirTarget;miRNATAP -0.891341251501579 1.84816652978499e-18 NA NA NA hsa-miR-33a-3p COL1A2 0.540032749009224 0.00270907254062352 0.890733647925744 0.000839239456437956 MirTarget -0.378132940882691 6.61624603984982e-07 NA NA NA hsa-miR-342-3p COL1A2 0.34628335679908 0.0121498405984511 0.890733647925744 0.000839239456437956 miRanda;miRNATAP -0.260410167669295 0.00903487777492384 NA NA NA hsa-miR-363-3p COL1A2 -0.318588561792557 0.232403434324873 0.890733647925744 0.000839239456437956 MirTarget -0.350944997148252 2.67575636324669e-12 NA NA NA hsa-miR-3934-5p COL1A2 1.1034968088853 9.61370357711436e-10 0.890733647925744 0.000839239456437956 MirTarget -0.249414475818915 0.000902613258435746 NA NA NA hsa-miR-500a-5p COL1A2 0.202654345352218 0.2571507084955 0.890733647925744 0.000839239456437956 miRNATAP -0.49982935519354 2.828871903413e-11 NA NA NA hsa-miR-590-3p COL1A2 0.9225805269779 6.0121446263776e-11 0.890733647925744 0.000839239456437956 miRanda -0.477356548958952 4.13843718293378e-07 NA NA NA hsa-miR-7-1-3p COL1A2 1.23074353429962 9.62692371802457e-18 0.890733647925744 0.000839239456437956 mirMAP -0.441362857082797 1.16972948473063e-06 NA NA NA hsa-miR-7-5p COL1A2 2.15398885914606 3.95055061525106e-16 0.890733647925744 0.000839239456437956 miRNATAP -0.185073969487755 0.000508993385386806 NA NA NA hsa-miR-92a-3p COL1A2 0.779792182638042 4.45572871602003e-09 0.890733647925744 0.000839239456437956 MirTarget;miRNATAP -0.488606201212702 1.21361002774195e-06 NA NA NA hsa-miR-98-5p COL1A2 0.278359437335009 0.00921227131925612 0.890733647925744 0.000839239456437956 MirTarget -0.787971357604448 5.45622721531167e-10 NA NA NA hsa-miR-29a-3p COL2A1 -1.03082784302378 5.4721714495133e-16 2.54152293868329 5.44014811652614e-07 MirTarget;miRNATAP -0.853027155896171 1.76367337554197e-05 NA NA NA hsa-miR-29b-3p COL2A1 -0.0219237619606503 0.883966228726957 2.54152293868329 5.44014811652614e-07 MirTarget;miRNATAP -0.539482887572209 0.0022038035613214 NA NA NA hsa-miR-29c-3p COL2A1 -1.50225173284958 1.90087771871443e-16 2.54152293868329 5.44014811652614e-07 MirTarget;miRNATAP -0.503265715481489 0.000266447478256648 NA NA NA hsa-miR-326 COL2A1 -2.468565451901 1.23182221778132e-19 2.54152293868329 5.44014811652614e-07 miRanda -0.239683126492007 0.00934736464391215 NA NA NA hsa-miR-514a-3p COL2A1 -0.574850577376421 0.156288003472901 2.54152293868329 5.44014811652614e-07 MirTarget;miRNATAP -0.178954461630574 0.00605916314466198 NA NA NA hsa-let-7g-5p COL4A1 0.0868874053614963 0.322163222422263 -0.140465694713308 0.38806769162527 miRNATAP -0.380928137748672 7.46140395725296e-05 NA NA NA hsa-miR-16-5p COL4A1 0.200674510503047 0.0593717079356147 -0.140465694713308 0.38806769162527 miRNAWalker2_validate -0.420583443123218 6.56618060867043e-08 NA NA NA hsa-miR-17-5p COL4A1 1.27106228457264 5.91314767482551e-14 -0.140465694713308 0.38806769162527 TargetScan -0.199944468193598 2.2534608760784e-05 NA NA NA hsa-miR-29b-3p COL4A1 -0.0219237619606503 0.883966228726957 -0.140465694713308 0.38806769162527 miRNAWalker2_validate;miRTarBase;miRNATAP -0.205287123476959 0.000210662255874545 NA NA NA hsa-miR-3065-5p COL4A1 -0.963317497666877 0.000100334146005009 -0.140465694713308 0.38806769162527 miRNATAP -0.121283327353412 0.00028210295279721 NA NA NA hsa-miR-320a COL4A1 0.25030125889857 0.0695425511666725 -0.140465694713308 0.38806769162527 miRanda -0.154969336433759 0.010531302338224 NA NA NA hsa-miR-362-3p COL4A1 -0.604045380242671 0.000132629619624125 -0.140465694713308 0.38806769162527 miRanda -0.22060286007283 2.36595653186656e-05 NA NA NA hsa-miR-421 COL4A1 1.16807936195133 1.4164941985739e-11 -0.140465694713308 0.38806769162527 miRanda -0.199278543305868 2.01886917324464e-05 NA NA NA hsa-miR-429 COL4A1 1.44127712764248 1.7824212712414e-11 -0.140465694713308 0.38806769162527 miRanda;miRNATAP -0.204885006761557 3.41140509918993e-08 NA NA NA hsa-miR-590-3p COL4A1 0.9225805269779 6.0121446263776e-11 -0.140465694713308 0.38806769162527 miRanda -0.218172880519864 0.000148067942409522 NA NA NA hsa-miR-590-5p COL4A1 1.22823897140696 7.5538778278798e-17 -0.140465694713308 0.38806769162527 miRanda;miRNATAP -0.206076215682359 0.000134400226091139 NA NA NA hsa-miR-769-3p COL4A1 1.69905535351918 1.30902489673511e-18 -0.140465694713308 0.38806769162527 miRNAWalker2_validate -0.105793556626023 0.0101027942583118 NA NA NA hsa-miR-92a-3p COL4A1 0.779792182638042 4.45572871602003e-09 -0.140465694713308 0.38806769162527 miRNAWalker2_validate -0.148259281327764 0.0161905559566667 NA NA NA hsa-let-7g-5p COL4A2 0.0868874053614963 0.322163222422263 -0.374797428465049 0.0273508146338502 miRNATAP -0.322983230402394 0.00138874264147651 NA NA NA hsa-miR-16-5p COL4A2 0.200674510503047 0.0593717079356147 -0.374797428465049 0.0273508146338502 miRNAWalker2_validate -0.419143008447876 2.83430010636868e-07 NA NA NA hsa-miR-26b-5p COL4A2 -0.0183893267106221 0.882303333465809 -0.374797428465049 0.0273508146338502 miRNAWalker2_validate -0.235567240651206 0.000835737217969797 NA NA NA hsa-miR-29b-3p COL4A2 -0.0219237619606503 0.883966228726957 -0.374797428465049 0.0273508146338502 miRTarBase;MirTarget;miRNATAP -0.191248495856199 0.000994957092931818 NA NA NA hsa-miR-92a-3p COL4A2 0.779792182638042 4.45572871602003e-09 -0.374797428465049 0.0273508146338502 miRNAWalker2_validate -0.152378788256917 0.0182410577062661 NA NA NA hsa-miR-106a-5p COL4A3 0.887689359198128 2.74215376899957e-05 -5.06356426296223 2.15244831863579e-37 MirTarget;miRNATAP -0.572217367585124 3.22360895849213e-08 NA NA NA hsa-miR-106b-5p COL4A3 0.768146314773296 1.22330832259683e-08 -5.06356426296223 2.15244831863579e-37 MirTarget;miRNATAP -1.02457967225704 1.85299440226535e-10 NA NA NA hsa-miR-135b-5p COL4A3 1.57294269928689 3.57109531929976e-09 -5.06356426296223 2.15244831863579e-37 MirTarget -0.181027560693249 0.0283335960884226 NA NA NA hsa-miR-15b-3p COL4A3 0.720785796663996 5.61234325663636e-07 -5.06356426296223 2.15244831863579e-37 mirMAP -0.901042257312568 2.77446158457036e-09 NA NA NA hsa-miR-16-2-3p COL4A3 0.505774348451832 0.00083906759991608 -5.06356426296223 2.15244831863579e-37 mirMAP -0.615889703789823 2.81713404669033e-05 NA NA NA hsa-miR-17-5p COL4A3 1.27106228457264 5.91314767482551e-14 -5.06356426296223 2.15244831863579e-37 MirTarget;TargetScan;miRNATAP -0.933202411700994 6.29946348169926e-14 NA NA NA hsa-miR-200b-3p COL4A3 1.24269422431788 9.2707509169586e-11 -5.06356426296223 2.15244831863579e-37 TargetScan -0.581717726985444 2.50593978720344e-07 NA NA NA hsa-miR-200c-3p COL4A3 1.44830286955223 1.39903737828795e-22 -5.06356426296223 2.15244831863579e-37 miRNATAP -1.11895965762176 5.20632140533185e-16 NA NA NA hsa-miR-20a-5p COL4A3 0.758237786270513 3.11867983980517e-05 -5.06356426296223 2.15244831863579e-37 MirTarget;miRNATAP -0.53954132068111 8.76594979536364e-06 NA NA NA hsa-miR-20b-5p COL4A3 0.396943783991848 0.194012869265072 -5.06356426296223 2.15244831863579e-37 MirTarget;miRNATAP -0.17679966538381 0.0160969947506353 NA NA NA hsa-miR-335-3p COL4A3 0.462639143507351 0.00828753288457869 -5.06356426296223 2.15244831863579e-37 mirMAP -0.260909876457019 0.0420411204130255 NA NA NA hsa-miR-33a-3p COL4A3 0.540032749009224 0.00270907254062352 -5.06356426296223 2.15244831863579e-37 MirTarget -0.504295700485746 5.58657951101064e-05 NA NA NA hsa-miR-3607-3p COL4A3 0.797258097957342 0.000266170796527225 -5.06356426296223 2.15244831863579e-37 miRNATAP -0.359097085389173 0.000410927642418813 NA NA NA hsa-miR-370-3p COL4A3 1.24361113127137 6.04886490884005e-07 -5.06356426296223 2.15244831863579e-37 MirTarget -0.446210406763247 3.85206927020429e-07 NA NA NA hsa-miR-429 COL4A3 1.44127712764248 1.7824212712414e-11 -5.06356426296223 2.15244831863579e-37 miRanda;miRNATAP -0.544513897437455 5.90903458180847e-08 NA NA NA hsa-miR-501-3p COL4A3 0.530715169143691 0.000110157559189539 -5.06356426296223 2.15244831863579e-37 miRNATAP -0.478360097815849 0.00336283896286047 NA NA NA hsa-miR-539-5p COL4A3 1.67998239253065 8.87745362575108e-13 -5.06356426296223 2.15244831863579e-37 MirTarget -0.588200484698252 9.42366096263317e-11 NA NA NA hsa-miR-590-3p COL4A3 0.9225805269779 6.0121446263776e-11 -5.06356426296223 2.15244831863579e-37 miRanda -0.739694992578339 1.70998954256112e-06 NA NA NA hsa-miR-625-5p COL4A3 1.04596928343988 2.07794141514857e-09 -5.06356426296223 2.15244831863579e-37 MirTarget -0.494605962539391 8.66073170504994e-05 NA NA NA hsa-miR-7-1-3p COL4A3 1.23074353429962 9.62692371802457e-18 -5.06356426296223 2.15244831863579e-37 MirTarget -0.884631653269766 1.95350153107591e-09 NA NA NA hsa-miR-93-3p COL4A3 1.87333981556813 3.67417899907584e-29 -5.06356426296223 2.15244831863579e-37 miRNATAP -1.18555822244913 4.20001932684249e-24 NA NA NA hsa-miR-93-5p COL4A3 1.27151657903037 1.96654008726155e-14 -5.06356426296223 2.15244831863579e-37 MirTarget;miRNATAP -1.00183313704644 1.85470746863219e-15 NA NA NA hsa-miR-944 COL4A3 6.31318502943581 6.64615435406088e-56 -5.06356426296223 2.15244831863579e-37 mirMAP -0.589492417514556 5.33354505790559e-43 NA NA NA hsa-miR-130a-3p COL4A4 -0.124312418026753 0.382773698737926 -3.73696298659838 1.52659399460254e-31 mirMAP -0.311844132254056 0.0133787196935183 NA NA NA hsa-miR-130b-3p COL4A4 2.60393336883065 1.5273795648739e-42 -3.73696298659838 1.52659399460254e-31 mirMAP -0.920116355262942 1.96725893043987e-33 NA NA NA hsa-miR-15b-3p COL4A4 0.720785796663996 5.61234325663636e-07 -3.73696298659838 1.52659399460254e-31 MirTarget -0.650305055584483 7.3635645660038e-08 NA NA NA hsa-miR-182-5p COL4A4 2.16789823981744 5.64205069446407e-26 -3.73696298659838 1.52659399460254e-31 MirTarget -0.559983711460465 1.05958675241782e-12 NA NA NA hsa-miR-203a-3p COL4A4 1.5633612920102 3.65621097298307e-07 -3.73696298659838 1.52659399460254e-31 MirTarget -0.465113463877101 1.73169478157368e-17 NA NA NA hsa-miR-224-3p COL4A4 0.735089473712282 0.00175854245266733 -3.73696298659838 1.52659399460254e-31 mirMAP -0.310622561535493 4.25140357316331e-05 NA NA NA hsa-miR-299-5p COL4A4 0.541138282807162 0.0126524869126082 -3.73696298659838 1.52659399460254e-31 miRNATAP -0.438401425376147 7.51081693392901e-08 NA NA NA hsa-miR-301a-3p COL4A4 1.23940945645189 2.05328421457283e-11 -3.73696298659838 1.52659399460254e-31 mirMAP -0.631383232259234 5.11162453237058e-12 NA NA NA hsa-miR-33a-3p COL4A4 0.540032749009224 0.00270907254062352 -3.73696298659838 1.52659399460254e-31 mirMAP -0.379393564677534 0.000136340881828275 NA NA NA hsa-miR-361-5p COL4A4 -0.0236974652105824 0.799888526193556 -3.73696298659838 1.52659399460254e-31 MirTarget;miRanda -0.38754297534244 0.0466651786490239 NA NA NA hsa-miR-429 COL4A4 1.44127712764248 1.7824212712414e-11 -3.73696298659838 1.52659399460254e-31 miRNATAP -0.496244258803822 3.74486878834808e-10 NA NA NA hsa-miR-454-3p COL4A4 0.942883363058312 9.73843658862518e-10 -3.73696298659838 1.52659399460254e-31 mirMAP -0.502978274555991 7.75484646229303e-06 NA NA NA hsa-miR-501-5p COL4A4 0.316742767698094 0.0632047358679198 -3.73696298659838 1.52659399460254e-31 mirMAP -0.209644674702763 0.0461668326349332 NA NA NA hsa-miR-532-3p COL4A4 0.62928908928122 1.1124581803679e-05 -3.73696298659838 1.52659399460254e-31 miRNATAP -0.468365056842712 0.000143061733758533 NA NA NA hsa-miR-539-5p COL4A4 1.67998239253065 8.87745362575108e-13 -3.73696298659838 1.52659399460254e-31 mirMAP -0.457700351110103 2.28613440707779e-10 NA NA NA hsa-miR-576-5p COL4A4 0.993748428316612 2.24066125794743e-10 -3.73696298659838 1.52659399460254e-31 PITA -0.470139164630405 2.14764952599885e-05 NA NA NA hsa-miR-577 COL4A4 3.5197399300515 1.67960995324817e-16 -3.73696298659838 1.52659399460254e-31 mirMAP -0.205733780008014 3.61912897655551e-06 NA NA NA hsa-miR-589-3p COL4A4 1.64129600791754 3.03909323325799e-16 -3.73696298659838 1.52659399460254e-31 mirMAP -0.673327228034701 2.78013087133382e-16 NA NA NA hsa-miR-590-3p COL4A4 0.9225805269779 6.0121446263776e-11 -3.73696298659838 1.52659399460254e-31 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.545101784186245 9.31229085382715e-06 NA NA NA hsa-miR-616-3p COL4A4 1.84210973859322 4.49541996670696e-19 -3.73696298659838 1.52659399460254e-31 MirTarget -0.530806910990377 7.82905801843641e-10 NA NA NA hsa-miR-629-3p COL4A4 2.47046856327102 4.17622167602811e-39 -3.73696298659838 1.52659399460254e-31 MirTarget;miRNATAP -0.606366336494238 1.83727331095673e-13 NA NA NA hsa-miR-944 COL4A4 6.31318502943581 6.64615435406088e-56 -3.73696298659838 1.52659399460254e-31 PITA;mirMAP;miRNATAP -0.475711420813573 8.27872401918842e-45 NA NA NA hsa-miR-146b-5p COL4A5 -0.432155779449763 0.00591587599739451 1.35271829571406 3.24507522153315e-07 miRanda -0.172315631826949 0.0498160999179676 NA NA NA hsa-miR-193a-3p COL4A5 -0.399504718785393 0.0108866663328791 1.35271829571406 3.24507522153315e-07 miRanda -0.18766651941321 0.0330877786584377 NA NA NA hsa-miR-217 COL4A5 -0.501449190998853 0.0366805136279841 1.35271829571406 3.24507522153315e-07 PITA;miRanda -0.124050210492881 0.0304361542050387 NA NA NA hsa-miR-29a-3p COL4A5 -1.03082784302378 5.4721714495133e-16 1.35271829571406 3.24507522153315e-07 miRNATAP -0.47305152959741 4.9429226757901e-06 NA NA NA hsa-miR-29b-3p COL4A5 -0.0219237619606503 0.883966228726957 1.35271829571406 3.24507522153315e-07 miRNATAP -0.234856273082828 0.0108403212426159 NA NA NA hsa-miR-29c-3p COL4A5 -1.50225173284958 1.90087771871443e-16 1.35271829571406 3.24507522153315e-07 miRNATAP -0.311781470327605 1.41066028910744e-05 NA NA NA hsa-miR-330-3p COL4A5 0.00879260240870505 0.951284239507664 1.35271829571406 3.24507522153315e-07 PITA -0.261210013899558 0.00664035907564835 NA NA NA hsa-miR-338-5p COL4A5 -2.99778534642888 2.74111905046628e-39 1.35271829571406 3.24507522153315e-07 PITA;miRNATAP -0.312110828410853 5.17225551522737e-09 NA NA NA hsa-let-7a-5p COL4A6 -0.644221394537031 9.97672106245846e-14 2.56430071258849 2.4965260029878e-09 TargetScan -0.659412701353041 0.010042476381064 NA NA NA hsa-miR-29a-3p COL4A6 -1.03082784302378 5.4721714495133e-16 2.56430071258849 2.4965260029878e-09 miRNATAP -0.743232689113667 1.16543548165098e-05 NA NA NA hsa-miR-29b-3p COL4A6 -0.0219237619606503 0.883966228726957 2.56430071258849 2.4965260029878e-09 miRNATAP -0.313512934275541 0.0377900864662595 NA NA NA hsa-miR-29c-3p COL4A6 -1.50225173284958 1.90087771871443e-16 2.56430071258849 2.4965260029878e-09 miRNATAP -0.529824147451237 6.25632929704371e-06 NA NA NA hsa-miR-326 COL4A6 -2.468565451901 1.23182221778132e-19 2.56430071258849 2.4965260029878e-09 miRanda -0.578165680155414 3.132763570659e-14 NA NA NA hsa-miR-1301-3p COL6A1 1.75268901788708 9.77575865554511e-22 0.0878350707155047 0.676240767227605 miRNAWalker2_validate -0.349857970107493 1.14430431253794e-10 NA NA NA hsa-miR-324-5p COL6A1 1.21634042749489 1.07503319022833e-13 0.0878350707155047 0.676240767227605 miRNAWalker2_validate -0.345521005877991 3.4506830222529e-08 NA NA NA hsa-miR-335-5p COL6A1 -0.324086861750615 0.0899025346373434 0.0878350707155047 0.676240767227605 miRNAWalker2_validate -0.328773411026872 2.6293379579601e-09 NA NA NA hsa-miR-3928-3p COL6A2 1.65357644453037 7.50998419099203e-15 -0.0978548420503547 0.64546427896348 miRNAWalker2_validate -0.112749532092162 0.0265545790246093 NA NA NA hsa-miR-1226-3p COL6A3 1.27791843537411 2.95203258399206e-10 0.376800348705988 0.11166931803122 MirTarget -0.24835332037853 2.83221266525868e-05 NA NA NA hsa-miR-28-5p COL6A3 0.189534080376749 0.0278108067630943 0.376800348705988 0.11166931803122 miRanda -0.649729212192026 4.86490718937036e-06 NA NA NA hsa-miR-29b-3p COL6A3 -0.0219237619606503 0.883966228726957 0.376800348705988 0.11166931803122 MirTarget;miRNATAP -0.182877655914915 0.0244166700226586 NA NA NA hsa-miR-320a COL6A3 0.25030125889857 0.0695425511666725 0.376800348705988 0.11166931803122 miRanda -0.318595717648563 0.000293453060414055 NA NA NA hsa-miR-320b COL6A3 1.16387990475466 1.33051259463572e-10 0.376800348705988 0.11166931803122 miRanda -0.149471651849154 0.0222953893158608 NA NA NA hsa-miR-362-3p COL6A3 -0.604045380242671 0.000132629619624125 0.376800348705988 0.11166931803122 miRanda -0.412547466822545 4.69208558241095e-08 NA NA NA hsa-miR-429 COL6A3 1.44127712764248 1.7824212712414e-11 0.376800348705988 0.11166931803122 miRNATAP -0.317593944088129 4.07524146470983e-09 NA NA NA hsa-miR-590-3p COL6A3 0.9225805269779 6.0121446263776e-11 0.376800348705988 0.11166931803122 miRanda -0.441292977647672 1.09863590534514e-07 NA NA NA hsa-miR-877-5p COL6A3 2.90093737151303 2.52134268016683e-35 0.376800348705988 0.11166931803122 MirTarget;miRNATAP -0.191255008480645 6.0359226611954e-05 NA NA NA hsa-miR-103a-2-5p COL6A6 1.89326161187553 3.13008877983253e-17 -4.74801086229794 1.17069177113383e-32 mirMAP -0.653200253447638 4.5374299027252e-12 NA NA NA hsa-miR-429 COL6A6 1.44127712764248 1.7824212712414e-11 -4.74801086229794 1.17069177113383e-32 miRanda -0.531141886066758 1.04359940832103e-07 NA NA NA hsa-miR-501-5p COL6A6 0.316742767698094 0.0632047358679198 -4.74801086229794 1.17069177113383e-32 mirMAP -0.324328442686965 0.0135868134513811 NA NA NA hsa-miR-532-3p COL6A6 0.62928908928122 1.1124581803679e-05 -4.74801086229794 1.17069177113383e-32 MirTarget -0.514234191505939 0.000872968430673265 NA NA NA hsa-miR-576-5p COL6A6 0.993748428316612 2.24066125794743e-10 -4.74801086229794 1.17069177113383e-32 mirMAP -0.636722159381645 4.0778644621164e-06 NA NA NA hsa-miR-577 COL6A6 3.5197399300515 1.67960995324817e-16 -4.74801086229794 1.17069177113383e-32 MirTarget;mirMAP -0.363179863053605 3.35498237882526e-11 NA NA NA hsa-miR-590-3p COL6A6 0.9225805269779 6.0121446263776e-11 -4.74801086229794 1.17069177113383e-32 MirTarget;miRanda;mirMAP -0.800992756679824 1.69063055886397e-07 NA NA NA hsa-miR-590-5p COL6A6 1.22823897140696 7.5538778278798e-17 -4.74801086229794 1.17069177113383e-32 miRanda -1.19624898874828 1.0016314538774e-17 NA NA NA hsa-miR-616-5p COL6A6 2.3596511369846 3.26881700557061e-22 -4.74801086229794 1.17069177113383e-32 mirMAP -0.637749186968163 1.63785697669766e-13 NA NA NA hsa-miR-944 COL6A6 6.31318502943581 6.64615435406088e-56 -4.74801086229794 1.17069177113383e-32 mirMAP -0.477805264202907 8.96269643316902e-27 NA NA NA hsa-let-7b-3p COL9A1 -0.39527315467518 0.0023287663817318 1.12865224760386 0.00826681181544175 mirMAP -0.469247541733047 0.00559755793605733 NA NA NA hsa-let-7f-1-3p COL9A1 0.0152174523424196 0.909387255829372 1.12865224760386 0.00826681181544175 mirMAP -0.537326464260642 0.00117107511499608 NA NA NA hsa-miR-27a-5p COL9A3 -1.31547462497736 7.27072900749906e-12 2.71553706402451 2.15016694570141e-11 MirTarget -0.390609308204929 0.000286233668533034 NA NA NA hsa-miR-30a-5p COL9A3 -2.98793938555326 1.93840183838367e-49 2.71553706402451 2.15016694570141e-11 MirTarget -0.39638843631865 1.49991731854902e-05 NA NA NA hsa-miR-30b-5p COL9A3 -1.50117013761001 1.78247435398346e-20 2.71553706402451 2.15016694570141e-11 MirTarget -0.375301488263649 0.00270770470092794 NA NA NA hsa-miR-30d-5p COL9A3 -2.06908130936031 2.23574479943606e-47 2.71553706402451 2.15016694570141e-11 MirTarget -0.580694476530012 8.50764153678641e-06 NA NA NA hsa-miR-486-5p COL9A3 -3.31030668897609 1.04617579408648e-33 2.71553706402451 2.15016694570141e-11 miRanda -0.338731507293755 1.47658951594789e-06 NA NA NA hsa-miR-129-5p CREB3L1 2.0409652261565 1.19491474689015e-07 -1.70623417757531 9.57469175697195e-12 miRanda -0.174105066239962 1.50828747148663e-07 NA NA NA hsa-miR-182-5p CREB3L1 2.16789823981744 5.64205069446407e-26 -1.70623417757531 9.57469175697195e-12 MirTarget -0.505022878802749 9.50174068602645e-19 NA NA NA hsa-miR-320b CREB3L1 1.16387990475466 1.33051259463572e-10 -1.70623417757531 9.57469175697195e-12 miRanda -0.203079140341755 0.00424879919073446 NA NA NA hsa-let-7d-5p CREB3L2 0.0470413504723624 0.6502410569426 -0.288564843212093 0.0142513192550709 mirMAP -0.154303276224327 0.00883473066963993 NA NA NA hsa-miR-106a-5p CREB3L2 0.887689359198128 2.74215376899957e-05 -0.288564843212093 0.0142513192550709 mirMAP -0.21060770254607 1.03277575668536e-14 NA NA NA hsa-miR-106b-5p CREB3L2 0.768146314773296 1.22330832259683e-08 -0.288564843212093 0.0142513192550709 mirMAP -0.243882012858079 1.85654865036354e-08 NA NA NA hsa-miR-1271-5p CREB3L2 1.0987045785026 1.5617128114028e-09 -0.288564843212093 0.0142513192550709 MirTarget -0.154425608795367 1.4847563030079e-06 NA NA NA hsa-miR-128-3p CREB3L2 0.940275845868474 5.3111687457665e-10 -0.288564843212093 0.0142513192550709 MirTarget -0.167074666747324 1.58739025868751e-05 NA NA NA hsa-miR-141-3p CREB3L2 1.96958415696982 1.4648441542521e-24 -0.288564843212093 0.0142513192550709 MirTarget -0.182456490078092 2.0167042415263e-10 NA NA NA hsa-miR-16-2-3p CREB3L2 0.505774348451832 0.00083906759991608 -0.288564843212093 0.0142513192550709 mirMAP -0.216533231567372 3.04554723668581e-08 NA NA NA hsa-miR-16-5p CREB3L2 0.200674510503047 0.0593717079356147 -0.288564843212093 0.0142513192550709 miRNAWalker2_validate -0.316092272915201 2.02339704843364e-08 NA NA NA hsa-miR-17-5p CREB3L2 1.27106228457264 5.91314767482551e-14 -0.288564843212093 0.0142513192550709 mirMAP -0.274676091687746 1.01808705229581e-16 NA NA NA hsa-miR-185-5p CREB3L2 0.0188696639275925 0.858581663208548 -0.288564843212093 0.0142513192550709 MirTarget -0.216823745001568 0.000159134272854753 NA NA NA hsa-miR-186-5p CREB3L2 0.439819047090102 6.33375570167175e-05 -0.288564843212093 0.0142513192550709 MirTarget -0.140792366181678 0.0103634027425994 NA NA NA hsa-miR-18a-3p CREB3L2 2.05585109851169 1.40576069637563e-20 -0.288564843212093 0.0142513192550709 MirTarget -0.15457976489959 1.23077001408935e-09 NA NA NA hsa-miR-197-3p CREB3L2 0.72925569501114 3.6335380891617e-08 -0.288564843212093 0.0142513192550709 mirMAP -0.158249186245929 0.000411214387104275 NA NA NA hsa-miR-19b-3p CREB3L2 0.786722036548617 1.29623163115342e-06 -0.288564843212093 0.0142513192550709 miRNAWalker2_validate -0.247338676469242 4.2139130897356e-12 NA NA NA hsa-miR-200a-3p CREB3L2 1.41385743755862 3.01641811769439e-11 -0.288564843212093 0.0142513192550709 MirTarget -0.172473313169551 1.56125531379508e-10 NA NA NA hsa-miR-20a-5p CREB3L2 0.758237786270513 3.11867983980517e-05 -0.288564843212093 0.0142513192550709 mirMAP -0.235798563095491 1.2215799471887e-13 NA NA NA hsa-miR-20b-5p CREB3L2 0.396943783991848 0.194012869265072 -0.288564843212093 0.0142513192550709 mirMAP -0.103412223659934 9.87981235697368e-08 NA NA NA hsa-miR-24-3p CREB3L2 0.272730498465254 0.0053154135686548 -0.288564843212093 0.0142513192550709 miRNATAP -0.1325535367868 0.0336359524942597 NA NA NA hsa-miR-25-3p CREB3L2 0.324190582599831 0.0073283146172755 -0.288564843212093 0.0142513192550709 MirTarget;miRNATAP -0.209245531744503 2.59813103485012e-05 NA NA NA hsa-miR-32-5p CREB3L2 -0.349953074737666 0.00689126382132822 -0.288564843212093 0.0142513192550709 MirTarget;miRNATAP -0.111818460694388 0.0167091229300318 NA NA NA hsa-miR-361-5p CREB3L2 -0.0236974652105824 0.799888526193556 -0.288564843212093 0.0142513192550709 miRanda -0.150242289290326 0.0222966172757969 NA NA NA hsa-miR-362-5p CREB3L2 0.26329593259106 0.182949931130249 -0.288564843212093 0.0142513192550709 mirMAP -0.132734058340746 1.1513169842874e-05 NA NA NA hsa-miR-429 CREB3L2 1.44127712764248 1.7824212712414e-11 -0.288564843212093 0.0142513192550709 miRNATAP -0.150900617259829 2.00714755369223e-08 NA NA NA hsa-miR-501-5p CREB3L2 0.316742767698094 0.0632047358679198 -0.288564843212093 0.0142513192550709 mirMAP -0.107376297456572 0.0024132331729697 NA NA NA hsa-miR-590-3p CREB3L2 0.9225805269779 6.0121446263776e-11 -0.288564843212093 0.0142513192550709 miRanda;miRNATAP -0.108890991525538 0.0093377240681413 NA NA NA hsa-miR-616-5p CREB3L2 2.3596511369846 3.26881700557061e-22 -0.288564843212093 0.0142513192550709 mirMAP -0.107932346748956 6.06097461854754e-06 NA NA NA hsa-miR-7-1-3p CREB3L2 1.23074353429962 9.62692371802457e-18 -0.288564843212093 0.0142513192550709 mirMAP -0.1827812617474 4.65672794581951e-06 NA NA NA hsa-miR-92a-1-5p CREB3L2 1.28603304638839 1.39402689315997e-08 -0.288564843212093 0.0142513192550709 MirTarget -0.155878662036176 1.17234263051388e-09 NA NA NA hsa-miR-92a-3p CREB3L2 0.779792182638042 4.45572871602003e-09 -0.288564843212093 0.0142513192550709 miRNAWalker2_validate;MirTarget;miRNATAP -0.336471849447305 5.97986387131652e-15 NA NA NA hsa-miR-92b-3p CREB3L2 0.660348894715342 5.8183923925395e-06 -0.288564843212093 0.0142513192550709 MirTarget;miRNATAP -0.193367426783525 1.94338411674796e-06 NA NA NA hsa-miR-140-5p CREB3L4 -0.615965395622439 1.05820583250804e-08 0.661545746618656 2.36760133338545e-07 miRanda -0.202585931158153 0.000901156884789642 NA NA NA hsa-miR-106b-5p CREB5 0.768146314773296 1.22330832259683e-08 -0.881371535776069 0.000275559309505198 MirTarget;miRNATAP -0.308865923573396 0.000695892804233061 NA NA NA hsa-miR-107 CREB5 -0.456345046928702 5.29231946717953e-06 -0.881371535776069 0.000275559309505198 miRNATAP -0.27195427310004 0.0296399240858432 NA NA NA hsa-miR-130b-3p CREB5 2.60393336883065 1.5273795648739e-42 -0.881371535776069 0.000275559309505198 miRNATAP -0.210308147785858 0.000300749526140001 NA NA NA hsa-miR-141-3p CREB5 1.96958415696982 1.4648441542521e-24 -0.881371535776069 0.000275559309505198 mirMAP -0.135664929559946 0.0258334175742063 NA NA NA hsa-miR-142-3p CREB5 0.674575513897478 0.000112525767514321 -0.881371535776069 0.000275559309505198 miRNATAP -0.216825336618466 0.0022405653723163 NA NA NA hsa-miR-142-5p CREB5 -0.0363288420100352 0.821716201807163 -0.881371535776069 0.000275559309505198 mirMAP -0.251002633610795 0.00122629974725478 NA NA NA hsa-miR-186-5p CREB5 0.439819047090102 6.33375570167175e-05 -0.881371535776069 0.000275559309505198 mirMAP -0.430421840114929 0.00014469586560045 NA NA NA hsa-miR-188-3p CREB5 0.964670976618067 1.62224093573704e-05 -0.881371535776069 0.000275559309505198 miRNATAP -0.162917377664894 0.00493450536375357 NA NA NA hsa-miR-200a-3p CREB5 1.41385743755862 3.01641811769439e-11 -0.881371535776069 0.000275559309505198 mirMAP -0.13200757540387 0.0209942326210408 NA NA NA hsa-miR-200c-3p CREB5 1.44830286955223 1.39903737828795e-22 -0.881371535776069 0.000275559309505198 miRNATAP -0.246107895445578 0.00198411188253391 NA NA NA hsa-miR-21-3p CREB5 0.924068840797428 6.92652443457631e-12 -0.881371535776069 0.000275559309505198 mirMAP -0.184793624154552 0.0416963721668159 NA NA NA hsa-miR-212-3p CREB5 0.652267799788663 3.93810796447291e-05 -0.881371535776069 0.000275559309505198 miRNATAP -0.238383891175226 0.00233991737909527 NA NA NA hsa-miR-26b-3p CREB5 0.157675322982898 0.216101238239109 -0.881371535776069 0.000275559309505198 MirTarget -0.301330708766003 0.00224209406307941 NA NA NA hsa-miR-301a-3p CREB5 1.23940945645189 2.05328421457283e-11 -0.881371535776069 0.000275559309505198 miRNATAP -0.231585144272142 0.000409824306060742 NA NA NA hsa-miR-320b CREB5 1.16387990475466 1.33051259463572e-10 -0.881371535776069 0.000275559309505198 MirTarget;PITA;miRanda;miRNATAP -0.192241865566548 0.00425663197500743 NA NA NA hsa-miR-330-3p CREB5 0.00879260240870505 0.951284239507664 -0.881371535776069 0.000275559309505198 MirTarget;mirMAP -0.421974449695152 1.0320597563972e-06 NA NA NA hsa-miR-335-3p CREB5 0.462639143507351 0.00828753288457869 -0.881371535776069 0.000275559309505198 mirMAP -0.147326064240803 0.0388651571103709 NA NA NA hsa-miR-340-5p CREB5 0.172446891226333 0.176440862972852 -0.881371535776069 0.000275559309505198 mirMAP -0.302273379342199 0.00214849613046235 NA NA NA hsa-miR-3607-3p CREB5 0.797258097957342 0.000266170796527225 -0.881371535776069 0.000275559309505198 mirMAP -0.139578717098702 0.0138872646149241 NA NA NA hsa-miR-429 CREB5 1.44127712764248 1.7824212712414e-11 -0.881371535776069 0.000275559309505198 PITA;miRanda;miRNATAP -0.15408490072713 0.0065171773933523 NA NA NA hsa-miR-454-3p CREB5 0.942883363058312 9.73843658862518e-10 -0.881371535776069 0.000275559309505198 miRNATAP -0.191859553063271 0.0157988510001626 NA NA NA hsa-miR-532-3p CREB5 0.62928908928122 1.1124581803679e-05 -0.881371535776069 0.000275559309505198 miRNATAP -0.205587668381892 0.0177822952346089 NA NA NA hsa-miR-542-3p CREB5 0.0944680117124008 0.47453779285373 -0.881371535776069 0.000275559309505198 PITA;miRNATAP -0.244662642575006 0.0102527646870828 NA NA NA hsa-miR-576-5p CREB5 0.993748428316612 2.24066125794743e-10 -0.881371535776069 0.000275559309505198 PITA;mirMAP -0.290797565367481 0.000181469120509243 NA NA NA hsa-miR-582-3p CREB5 -0.459710681681138 0.0173047578986498 -0.881371535776069 0.000275559309505198 MirTarget;PITA;miRNATAP -0.239561976708933 0.000194257417919388 NA NA NA hsa-miR-590-3p CREB5 0.9225805269779 6.0121446263776e-11 -0.881371535776069 0.000275559309505198 PITA;mirMAP -0.281088904695609 0.00117495101052841 NA NA NA hsa-miR-590-5p CREB5 1.22823897140696 7.5538778278798e-17 -0.881371535776069 0.000275559309505198 miRNATAP -0.271058442437467 0.000854224022504033 NA NA NA hsa-miR-616-5p CREB5 2.3596511369846 3.26881700557061e-22 -0.881371535776069 0.000275559309505198 MirTarget;mirMAP -0.183242195318866 0.000225583597241771 NA NA NA hsa-miR-671-5p CREB5 2.24826787094975 1.21091062273857e-36 -0.881371535776069 0.000275559309505198 PITA -0.162588120924194 0.0106638153221332 NA NA NA hsa-miR-7-1-3p CREB5 1.23074353429962 9.62692371802457e-18 -0.881371535776069 0.000275559309505198 mirMAP -0.224639620892154 0.00713191005730703 NA NA NA hsa-miR-766-3p CREB5 1.09936908655353 6.44158554385832e-12 -0.881371535776069 0.000275559309505198 MirTarget -0.387294685245621 2.46017247633163e-07 NA NA NA hsa-miR-769-5p CREB5 0.928214895090365 4.19801106060332e-11 -0.881371535776069 0.000275559309505198 miRNATAP -0.188028692576426 0.0306377496120678 NA NA NA hsa-miR-940 CREB5 1.91696621517233 1.3556247816872e-17 -0.881371535776069 0.000275559309505198 MirTarget -0.223906150022274 2.30323866114927e-05 NA NA NA hsa-miR-361-3p CRTC2 -0.491157107537441 1.38504517485595e-06 0.254437417637697 0.000326660187621721 miRNATAP -0.112566563948627 0.00151325867847781 NA NA NA hsa-miR-106a-5p CSF1 0.887689359198128 2.74215376899957e-05 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.367485771180105 1.15786922304189e-17 NA NA NA hsa-miR-106b-5p CSF1 0.768146314773296 1.22330832259683e-08 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.627623230789007 3.63951564016011e-21 NA NA NA hsa-miR-128-3p CSF1 0.940275845868474 5.3111687457665e-10 -1.72156703230295 1.79557278609482e-22 MirTarget -0.52381225712909 9.53386421967791e-19 22909061 By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR we identified a common target for both miR-128 and miR-152; We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro two major aspects of the metastatic potential of cancer cells; Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1 an important regulator of ovarian cancer motility ovarian cancer hsa-miR-130a-3p CSF1 -0.124312418026753 0.382773698737926 -1.72156703230295 1.79557278609482e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.174691863481462 0.00989144176358333 18823650 Finally downstream target validation was proven for the miR-130a whose downregulation was linked to the translational activation of the M-CSF gene a known resistance factor for ovarian cancer drug resistance ovarian cancer hsa-miR-130b-3p CSF1 2.60393336883065 1.5273795648739e-42 -1.72156703230295 1.79557278609482e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.514154636945496 1.20624555473608e-36 22005523 CSF-1 regulated by miR-130b was detected using Dual Luciferase Reporter system; CSF-1 expression was negatively associated with miR-130b level in ovarian tissues and cell lines; Luciferase assay validated CSF-1 is a direct target of miR-130b; Knock-down of CSF-1 sensitized ovarian cancer cells to anticancer drugs and could partially attenuate the resistance inducing effect of miR-130b inhibitors; Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3'-UTR of CSF-1 and the silencing of miR-130b may be mediated by DNA methylation drug resistance ovarian cancer hsa-miR-149-5p CSF1 3.1548412914629 4.44598605668453e-31 -1.72156703230295 1.79557278609482e-22 MirTarget -0.23688121514056 3.71052425951659e-14 NA NA NA hsa-miR-15b-5p CSF1 0.575042920336974 9.75508983626876e-06 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.587826462933807 7.15898155773128e-17 NA NA NA hsa-miR-16-5p CSF1 0.200674510503047 0.0593717079356147 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.440098789446227 1.0329624933945e-06 NA NA NA hsa-miR-17-5p CSF1 1.27106228457264 5.91314767482551e-14 -1.72156703230295 1.79557278609482e-22 TargetScan;miRNATAP -0.520335789753655 5.73146021081775e-24 NA NA NA hsa-miR-197-3p CSF1 0.72925569501114 3.6335380891617e-08 -1.72156703230295 1.79557278609482e-22 MirTarget -0.313460761950859 9.917133338125e-06 NA NA NA hsa-miR-205-5p CSF1 7.4255450988826 2.64056553520099e-76 -1.72156703230295 1.79557278609482e-22 MirTarget -0.180415136020944 5.44441087991181e-23 NA NA NA hsa-miR-20a-5p CSF1 0.758237786270513 3.11867983980517e-05 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.399992033916743 1.90272673486538e-15 NA NA NA hsa-miR-20b-5p CSF1 0.396943783991848 0.194012869265072 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.148428434680266 1.66327003016074e-06 NA NA NA hsa-miR-23a-5p CSF1 0.700108859043245 0.000788132353392114 -1.72156703230295 1.79557278609482e-22 MirTarget -0.139906155184438 0.00219931476887656 NA NA NA hsa-miR-27a-3p CSF1 0.140284703630369 0.213001086994521 -1.72156703230295 1.79557278609482e-22 MirTarget;miRNATAP -0.244934524905016 0.0043842665441386 NA NA NA hsa-miR-27b-3p CSF1 0.0774984459252845 0.455541249499373 -1.72156703230295 1.79557278609482e-22 MirTarget;miRNATAP -0.391096267171966 2.58766776938185e-05 NA NA NA hsa-miR-28-5p CSF1 0.189534080376749 0.0278108067630943 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.489675715730458 1.35416524343344e-05 NA NA NA hsa-miR-301a-3p CSF1 1.23940945645189 2.05328421457283e-11 -1.72156703230295 1.79557278609482e-22 MirTarget;miRNATAP -0.41224530607194 1.5487987381276e-17 NA NA NA hsa-miR-301b-3p CSF1 2.73590939539747 6.81394899610837e-22 -1.72156703230295 1.79557278609482e-22 MirTarget -0.318235170137506 6.99765833201055e-20 NA NA NA hsa-miR-335-5p CSF1 -0.324086861750615 0.0899025346373434 -1.72156703230295 1.79557278609482e-22 miRNAWalker2_validate -0.123975856646093 0.0135593179803286 NA NA NA hsa-miR-423-5p CSF1 0.427072818804231 0.0012124903743904 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.377207326895164 1.44789696452813e-07 NA NA NA hsa-miR-424-5p CSF1 1.50572404087407 4.24425395615445e-20 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.261099041907197 2.07097139415922e-06 NA NA NA hsa-miR-429 CSF1 1.44127712764248 1.7824212712414e-11 -1.72156703230295 1.79557278609482e-22 PITA;miRanda;miRNATAP -0.380028435651025 3.86210935740325e-20 NA NA NA hsa-miR-454-3p CSF1 0.942883363058312 9.73843658862518e-10 -1.72156703230295 1.79557278609482e-22 MirTarget;miRNATAP -0.457874902327798 7.35993400692753e-15 NA NA NA hsa-miR-455-3p CSF1 2.18142848948175 2.92546018153478e-26 -1.72156703230295 1.79557278609482e-22 mirMAP -0.197708778464817 4.30739773336059e-06 NA NA NA hsa-miR-505-3p CSF1 1.02991829785126 3.27959895590399e-13 -1.72156703230295 1.79557278609482e-22 miRNAWalker2_validate -0.458133152852224 8.27241912982375e-13 NA NA NA hsa-miR-532-3p CSF1 0.62928908928122 1.1124581803679e-05 -1.72156703230295 1.79557278609482e-22 MirTarget;PITA -0.317612784324906 1.38525290954234e-06 NA NA NA hsa-miR-629-3p CSF1 2.47046856327102 4.17622167602811e-39 -1.72156703230295 1.79557278609482e-22 mirMAP -0.30024352687357 1.53925094541378e-11 NA NA NA hsa-miR-708-5p CSF1 3.70808687333578 5.51249219545358e-54 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.339809077225742 5.65560551499827e-26 NA NA NA hsa-miR-93-5p CSF1 1.27151657903037 1.96654008726155e-14 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.524360581293607 1.75806357088522e-23 NA NA NA hsa-miR-939-5p CSF1 1.36997300674111 9.97643104288974e-13 -1.72156703230295 1.79557278609482e-22 MirTarget -0.246775823897325 1.18192822144264e-06 NA NA NA hsa-miR-940 CSF1 1.91696621517233 1.3556247816872e-17 -1.72156703230295 1.79557278609482e-22 MirTarget;PITA;miRNATAP -0.257497909940212 1.17690098329397e-10 NA NA NA hsa-miR-96-5p CSF1 2.81159638603625 3.72452637775194e-34 -1.72156703230295 1.79557278609482e-22 miRNATAP -0.423744134457523 1.19116459783448e-34 NA NA NA hsa-miR-339-5p CSF1R 0.695129802377533 1.42149990793285e-05 -1.59817623459597 4.69740740896212e-12 miRanda -0.548689222982084 6.06542479472159e-14 NA NA NA hsa-miR-629-3p CSF1R 2.47046856327102 4.17622167602811e-39 -1.59817623459597 4.69740740896212e-12 MirTarget -0.275325083042581 1.63087749379669e-06 NA NA NA hsa-miR-141-3p CSF3 1.96958415696982 1.4648441542521e-24 -4.82355827038254 2.2645288564133e-21 TargetScan;miRNATAP -0.947822902179565 3.1414717097604e-13 NA NA NA hsa-miR-188-3p CSF3 0.964670976618067 1.62224093573704e-05 -4.82355827038254 2.2645288564133e-21 miRNATAP -0.545586066264643 1.7085906188586e-05 NA NA NA hsa-miR-200a-3p CSF3 1.41385743755862 3.01641811769439e-11 -4.82355827038254 2.2645288564133e-21 miRNATAP -0.587799629061551 2.43474920525957e-06 NA NA NA hsa-miR-28-5p CSF3 0.189534080376749 0.0278108067630943 -4.82355827038254 2.2645288564133e-21 miRanda -1.1858767772052 0.000257795606636914 NA NA NA hsa-miR-339-5p CSF3 0.695129802377533 1.42149990793285e-05 -4.82355827038254 2.2645288564133e-21 miRanda -0.426178033264727 0.0125392479134514 NA NA NA hsa-miR-532-3p CSF3 0.62928908928122 1.1124581803679e-05 -4.82355827038254 2.2645288564133e-21 MirTarget;miRNATAP -0.519694266397638 0.00651616602668826 NA NA NA hsa-miR-577 CSF3 3.5197399300515 1.67960995324817e-16 -4.82355827038254 2.2645288564133e-21 PITA;miRNATAP -0.573236595751429 4.91876932879592e-18 NA NA NA hsa-miR-939-5p CSF3 1.36997300674111 9.97643104288974e-13 -4.82355827038254 2.2645288564133e-21 MirTarget -0.551611868265546 0.000172152643673954 NA NA NA hsa-miR-429 CSF3R 1.44127712764248 1.7824212712414e-11 -3.18196194597289 3.53098563436608e-30 miRanda -0.407284098496714 3.51980927945836e-09 NA NA NA hsa-miR-940 CSF3R 1.91696621517233 1.3556247816872e-17 -3.18196194597289 3.53098563436608e-30 MirTarget -0.410361875356063 2.15691286147512e-10 NA NA NA hsa-miR-101-3p DDIT4 -2.01992291103908 2.62945171087274e-42 1.39333652590185 6.26717509806381e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.522107980713971 3.47931983205541e-14 NA NA NA hsa-miR-139-5p DDIT4 -2.25560964518719 9.95317711940085e-30 1.39333652590185 6.26717509806381e-10 MirTarget;miRanda;miRNATAP -0.250739061614441 3.70966663315125e-06 NA NA NA hsa-miR-144-3p DDIT4 -3.16158517269344 5.21622863105405e-24 1.39333652590185 6.26717509806381e-10 miRNATAP -0.144215641144225 4.34489922781982e-05 NA NA NA hsa-miR-181a-5p DDIT4 -1.31879909071317 2.04570351303734e-24 1.39333652590185 6.26717509806381e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.34014116244012 6.97063224265709e-05 NA NA NA hsa-miR-181c-5p DDIT4 -1.36921360773694 5.61046203952059e-19 1.39333652590185 6.26717509806381e-10 MirTarget -0.369011543776305 3.3752889251955e-07 NA NA NA hsa-miR-30a-5p DDIT4 -2.98793938555326 1.93840183838367e-49 1.39333652590185 6.26717509806381e-10 MirTarget;miRNATAP -0.204730786322047 5.4067726174285e-05 NA NA NA hsa-miR-30b-5p DDIT4 -1.50117013761001 1.78247435398346e-20 1.39333652590185 6.26717509806381e-10 MirTarget -0.206930898522792 0.00278223238816659 NA NA NA hsa-miR-30d-5p DDIT4 -2.06908130936031 2.23574479943606e-47 1.39333652590185 6.26717509806381e-10 MirTarget;miRNATAP -0.428906533766487 1.83961049838381e-09 NA NA NA hsa-miR-32-5p DDIT4 -0.349953074737666 0.00689126382132822 1.39333652590185 6.26717509806381e-10 miRNATAP -0.26337174024372 0.00395337991250764 NA NA NA hsa-miR-324-3p EFNA1 0.800800089592099 8.38346636525273e-07 -0.262558038126319 0.0833075983345853 MirTarget;miRNATAP -0.166197800272772 0.000402966290925243 NA NA NA hsa-miR-326 EFNA1 -2.468565451901 1.23182221778132e-19 -0.262558038126319 0.0833075983345853 miRanda -0.111743398819089 3.33294779869445e-05 NA NA NA hsa-miR-940 EFNA1 1.91696621517233 1.3556247816872e-17 -0.262558038126319 0.0833075983345853 MirTarget -0.140202748301192 1.94312626535691e-05 NA NA NA hsa-miR-145-5p EFNA3 -1.08109692150888 5.28948625689113e-14 3.6716300409287 3.30175017890816e-58 miRNATAP -0.522038706542666 9.3032954304367e-09 NA NA NA hsa-miR-30a-5p EFNA3 -2.98793938555326 1.93840183838367e-49 3.6716300409287 3.30175017890816e-58 MirTarget;mirMAP;miRNATAP -0.701476688700119 1.32950449972463e-39 NA NA NA hsa-miR-30b-5p EFNA3 -1.50117013761001 1.78247435398346e-20 3.6716300409287 3.30175017890816e-58 MirTarget;mirMAP -0.497289735684198 2.61769087124094e-10 NA NA NA hsa-miR-30c-5p EFNA3 -0.426804145561029 0.00403132854321475 3.6716300409287 3.30175017890816e-58 MirTarget;mirMAP;miRNATAP -0.283837758285499 0.00207715598703989 NA NA NA hsa-miR-30d-5p EFNA3 -2.06908130936031 2.23574479943606e-47 3.6716300409287 3.30175017890816e-58 MirTarget;mirMAP;miRNATAP -0.835978060205808 2.96046983643201e-26 NA NA NA hsa-miR-326 EFNA3 -2.468565451901 1.23182221778132e-19 3.6716300409287 3.30175017890816e-58 MirTarget;miRanda;miRNATAP -0.412399262255423 1.63008862426762e-19 NA NA NA hsa-miR-342-5p EFNA3 0.0539558901968578 0.673491296758105 3.6716300409287 3.30175017890816e-58 miRNATAP -0.261686774496603 0.0153825147300479 NA NA NA hsa-miR-34c-5p EFNA3 -1.65096032312419 3.10893885639741e-06 3.6716300409287 3.30175017890816e-58 miRanda -0.115120489368531 0.00248797453178939 NA NA NA hsa-miR-361-3p EFNA3 -0.491157107537441 1.38504517485595e-06 3.6716300409287 3.30175017890816e-58 MirTarget;miRNATAP -1.13082426660617 1.44106171848833e-18 NA NA NA hsa-miR-486-5p EFNA3 -3.31030668897609 1.04617579408648e-33 3.6716300409287 3.30175017890816e-58 miRanda -0.446569450062809 1.39699394450067e-25 NA NA NA hsa-miR-140-5p EFNA4 -0.615965395622439 1.05820583250804e-08 1.95959526098604 4.89041485572508e-54 PITA;miRanda -0.405880300981311 2.14373995918222e-09 NA NA NA hsa-miR-1976 EFNA4 -1.13975694972151 3.52774818586224e-19 1.95959526098604 4.89041485572508e-54 MirTarget -0.483032628094006 2.59484107861889e-19 NA NA NA hsa-miR-361-3p EFNA4 -0.491157107537441 1.38504517485595e-06 1.95959526098604 4.89041485572508e-54 MirTarget;miRNATAP -0.49747467547255 4.12368241000283e-12 NA NA NA hsa-miR-103a-2-5p EFNA5 1.89326161187553 3.13008877983253e-17 -0.258008018953773 0.221179787563317 MirTarget -0.122470339708558 0.00893302726938171 NA NA NA hsa-miR-182-5p EFNA5 2.16789823981744 5.64205069446407e-26 -0.258008018953773 0.221179787563317 mirMAP;miRNATAP -0.104048189247614 0.0336832211443274 NA NA NA hsa-miR-19a-3p EFNA5 1.29022522620563 7.13786738838458e-11 -0.258008018953773 0.221179787563317 miRNATAP -0.170613313187411 0.00128154840765113 NA NA NA hsa-miR-19b-3p EFNA5 0.786722036548617 1.29623163115342e-06 -0.258008018953773 0.221179787563317 miRNATAP -0.162959358050996 0.0130701805422835 NA NA NA hsa-miR-362-3p EFNA5 -0.604045380242671 0.000132629619624125 -0.258008018953773 0.221179787563317 miRanda -0.156567645670327 0.0218348937162319 NA NA NA hsa-miR-501-5p EFNA5 0.316742767698094 0.0632047358679198 -0.258008018953773 0.221179787563317 mirMAP -0.130442547308802 0.0401308577759014 NA NA NA hsa-miR-92a-3p EFNA5 0.779792182638042 4.45572871602003e-09 -0.258008018953773 0.221179787563317 miRNAWalker2_validate -0.174554901576005 0.0292162822069393 NA NA NA hsa-miR-96-5p EFNA5 2.81159638603625 3.72452637775194e-34 -0.258008018953773 0.221179787563317 TargetScan -0.110637415090179 0.0093582930911942 NA NA NA hsa-miR-199a-5p EGF 0.125189495212204 0.398433974759894 0.443220906124235 0.185055411118332 miRanda -0.229244545165367 0.0487008282034277 NA NA NA hsa-miR-126-5p EGFR -1.94634635849451 2.4038399235921e-37 1.06732908733236 2.29736203202037e-05 mirMAP -0.277714466850021 0.000320145614560521 NA NA NA hsa-miR-133a-3p EGFR -2.91239323338447 8.28583105925908e-27 1.06732908733236 2.29736203202037e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.114618854185755 0.0105422271428035 26076812;25903369;26134491;24816813;26138587;22407299;27465833;23786162 Moreover the 3'-untranslated region 3'UTR of Her-2 the epidermal growth factor receptor EGFR that transduces cell growth signals appeared to be targeted by miR-133;MiR-133a expression was negatively correlated to lymphatic metastasis r = -0.182 P = 0.042 tumor size r = -0.253 P = 0.04 clinical TNM stages r = -0.154 P = 0.087 and EGFR protein expression r = -0.612 P < 0.001;miR 133a inhibits cervical cancer growth by targeting EGFR; The epidermal growth factor receptor EGFR was confirmed to be a direct target of miR-133a in cervical cancer cells using luciferase assay and western blotting; Restoration of miR-133a inhibited EGFR expression and activated the AKT and ERK signaling pathways; These results showed that miR-133a suppresses cervical cancer growth in vitro and in vivo through targeting EGFR suggesting that miR-133a can be a potential target for the treatment of cervical cancer;MiR-133a can inhibit cell invasiveness and cell growth through suppressing the expressions of IGF-1R TGFBR1 and EGFR which then influences the downstream signaling in lung cancer cell lines;Growth of glioblastoma is inhibited by miR 133 mediated EGFR suppression; Bioinformatic analysis was performed showing that miR-133 may target the 3'-untranslated region 3'-UTR of the epidermal growth factor receptor EGFR that transduces cell growth signals; Further the protein translation inhibition of EGFR by miR-133 was confirmed by a dual luciferase reporter assay; Together these data suggest that reduced miR-133 levels in GBM tissues promotes cell growth and decreases cell apoptosis possibly through targeting mRNA of EGFR to suppress its translation;We also provide the first evidence that miR-133 may target EGFR;Epidermal growth factor receptor EGFR expression and Akt phosphorylation were significantly suppressed after miR-133a transfection by western blot detection; miR-133a suppressed cell proliferation by suppressing the expression of EGFR and the phosphorylation of Akt;Bioinformatics prediction showed that epidermal growth factor receptor EGFR is a potential target for miR-133a; A dual luciferase reporter gene assay showed that miR-133a bound to the 3' UTR of EGFR but not a mutated 3' UTR thereby down-regulating the protein expression level; Accordingly we found that expression of EGFR protein decreased with increased expression of miR-133a in MCF-7 and MDA-MB-231 cells; These results demonstrate that miR-133a which may act as a tumor suppressor in breast cancer regulates the cell cycle and proliferation in tumorigenesis by targeting EGFR through the downstream signal molecule Akt ;staging;metastasis;tumor size;;;;;;tumorigenesis gastric cancer;lung squamous cell cancer;cervical and endocervical cancer;lung squamous cell cancer;glioblastoma;prostate cancer;breast cancer;breast cancer hsa-miR-140-5p EGFR -0.615965395622439 1.05820583250804e-08 1.06732908733236 2.29736203202037e-05 miRanda -0.503066841994129 2.43829385625658e-05 NA NA NA hsa-miR-142-3p EGFR 0.674575513897478 0.000112525767514321 1.06732908733236 2.29736203202037e-05 miRanda -0.18895987290897 0.0108515971555922 NA NA NA hsa-miR-146a-5p EGFR 0.260809574817216 0.135548468283814 1.06732908733236 2.29736203202037e-05 miRNAWalker2_validate -0.158349750865063 0.0344328866965035 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR -0.432155779449763 0.00591587599739451 1.06732908733236 2.29736203202037e-05 miRNATAP -0.261113501349999 0.0016237537485035 NA NA NA hsa-miR-148b-5p EGFR 1.36450535453179 3.94217334650158e-16 1.06732908733236 2.29736203202037e-05 mirMAP -0.154055283377675 0.040283631456982 NA NA NA hsa-miR-150-3p EGFR -0.939099326120231 0.000129741719282525 1.06732908733236 2.29736203202037e-05 mirMAP -0.18763635826686 0.000495698634937478 NA NA NA hsa-miR-155-5p EGFR 0.459859353454849 0.00515473360914761 1.06732908733236 2.29736203202037e-05 miRNAWalker2_validate;MirTarget -0.221547357705182 0.0051371868731884 NA NA NA hsa-miR-16-5p EGFR 0.200674510503047 0.0593717079356147 1.06732908733236 2.29736203202037e-05 miRNAWalker2_validate -0.243414481042627 0.04988939940484 NA NA NA hsa-miR-186-5p EGFR 0.439819047090102 6.33375570167175e-05 1.06732908733236 2.29736203202037e-05 mirMAP -0.366958436353904 0.00197220072695042 NA NA NA hsa-miR-29b-2-5p EGFR -1.04734214410093 8.2886590108117e-14 1.06732908733236 2.29736203202037e-05 mirMAP -0.396104456983789 9.48593205273928e-06 NA NA NA hsa-miR-30a-5p EGFR -2.98793938555326 1.93840183838367e-49 1.06732908733236 2.29736203202037e-05 miRNAWalker2_validate -0.168424694556858 0.00276058810569934 NA NA NA hsa-miR-30d-3p EGFR -1.57797039577408 4.48970383848141e-24 1.06732908733236 2.29736203202037e-05 mirMAP -0.243949881802102 0.00188401857771657 NA NA NA hsa-miR-335-5p EGFR -0.324086861750615 0.0899025346373434 1.06732908733236 2.29736203202037e-05 miRNAWalker2_validate -0.137909990605526 0.0437230059871367 NA NA NA hsa-miR-340-5p EGFR 0.172446891226333 0.176440862972852 1.06732908733236 2.29736203202037e-05 mirMAP -0.386931168757596 0.000159197792748916 NA NA NA hsa-miR-342-3p EGFR 0.34628335679908 0.0121498405984511 1.06732908733236 2.29736203202037e-05 miRanda -0.260851462680668 0.00584582623936756 NA NA NA hsa-miR-362-5p EGFR 0.26329593259106 0.182949931130249 1.06732908733236 2.29736203202037e-05 mirMAP -0.216740334475821 0.000992779592885406 NA NA NA hsa-miR-374a-3p EGFR -0.104091172625131 0.359725600505889 1.06732908733236 2.29736203202037e-05 mirMAP -0.239753807699984 0.0390786052190513 NA NA NA hsa-miR-374b-3p EGFR 0.166291930194592 0.223712737750778 1.06732908733236 2.29736203202037e-05 mirMAP -0.264388846352656 0.00631506916219635 NA NA NA hsa-miR-375 EGFR -2.57769028725587 1.42344309409034e-12 1.06732908733236 2.29736203202037e-05 miRanda -0.19887149199616 5.01748793869289e-09 NA NA NA hsa-miR-491-5p EGFR -0.0339006601107336 0.849160118543586 1.06732908733236 2.29736203202037e-05 miRanda -0.202291547326381 0.00633921493849003 25299770 This latter effect is due to direct targeting of epidermal growth factor receptor EGFR by miR-491-5p and consequent inhibition of downstream AKT and MAPK signalling pathways; Induction of apoptosis by miR-491-5p in this cell line is mimicked by a combination of EGFR inhibition together with a BH3-mimetic molecule ovarian cancer hsa-miR-501-5p EGFR 0.316742767698094 0.0632047358679198 1.06732908733236 2.29736203202037e-05 mirMAP -0.195703703805919 0.0107280587914611 NA NA NA hsa-miR-7-5p EGFR 2.15398885914606 3.95055061525106e-16 1.06732908733236 2.29736203202037e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.123787714120757 0.0147174008939912 21712475;25334070;20978205;26708917;23115635;25503932;25532106;27203220;25862909;24816687;24603851;24573489;25289099;23227519 To overcome the resistance we focused on EGFR suppression using microRNA-7 miR-7 targeting multiple sites in the 3'-untranslated region of EGFR mRNA;Furthermore inhibition of EGFR showed similar effects to miR-7 enforcement in 3LL cells; Taken together these findings revealed that miR-7 acts as an antitumor miRNA in 3LL by targeting and suppressing the expression of both EGFR and RAF-1 oncogenes;In this study we report the discovery and mechanistic characterization of the miRNA miR-7 as an oncogenic "oncomiR" and its role as a key mediator of EGFR signaling in lung cancer cells;In addition the experimental data also suggest that miR-7 can interfere with EGFR mRNA translation; In addition miR-7 may function by interfering with EGFR mRNA translation but not degradation;Several studies have demonstrated that microRNA-7 miR-7 regulates EGFR expression and Akt activity in a range of cancer cell types via its specific interaction with the EGFR mRNA 3'-untranslated region 3'-UTR; Together these data support the coordinate regulation of Akt signaling by miR-7 in HNC cells and suggest the therapeutic potential of miR-7 alone or in combination with EGFR TKIs in this disease;The potential for miR-7 to act as a tumor suppressor by coordinately regulating the epidermal growth factor receptor EGFR signaling pathway at several levels was examined; We investigated the tumor inhibitory effect of miR-7 in CRC with particular focus on the relationship between miR-7 and the EGFR pathway; The regulation of EGFR by miR-7 was examined with miR-7 precursor-transfected cells; Furthermore we investigated whether miR-7 suppresses proliferation of CRC cells in combination with cetuximab a monoclonal antibody against EGFR; In vitro assays showed that EGFR and RAF-1 are direct targets of miR-7 which potently suppressed the proliferation of CRC cells and interestingly that the growth inhibitory effect of each of these was enhanced by cetuximab;MiR-7 inhibited MCF-7/HER2Δ16 cell migration through a mechanism involving suppression of the miR-7 target gene EGFR; In contrast miR-7 inhibition of MCF-7/HER2Δ16 cell proliferation involved a pathway where miR-7 expression resulted in the inactivation of Src kinase independent of suppressed EGFR expression; Also independent of EGFR suppression reestablished miR-7 expression sensitized refractory MCF-7/HER2Δ16 cells to trastuzumab; We propose that miR-7 regulated pathways including EGFR and Src kinase represent targets for the therapeutic intervention of refractory and metastatic HER2Δ16 driven breast cancer;microRNA-7-5p miR-7-5p is a tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor EGFR signaling pathway;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;In recent years mounting evidence indicates that EGFR is a direct and functional target of miR-7; In this study we found that miR-7 expression was significantly downregulated in highly metastatic epithelial ovarian cancer EOC cell lines and metastatic tissues whereas the expression of EGFR correlated positively with metastasis in both EOC patients and cell lines; Finally the expression of miR-7 and EGFR in primary EOC with matched metastasis tissues was explored; It was showed that miR-7 is inversely correlated with EGFR; Taken together our results suggested that miR-7 inhibited tumor metastasis and reversed EMT through AKT and ERK1/2 pathway inactivation by reducing EGFR expression in EOC cell lines;We show that microRNA-7 miR-7 is a common regulator of the phosphoinositide-3-kinase PI3K/ATK and Raf/mitogen-activated protein kinase kinase MEK/extracellular signal-regulated kinase ERK pathways both of which are launched by EGFR through its two direct targets the transcription factors PI3K and Raf-1 respectively; We conclude that miR-7 is a potential tumor suppressor in glioblastoma that acts by targeting multiple oncogenes related to the downstream pathway of EGFR and may serve as a novel therapeutic target for malignant gliomas;Further study will investigate miR-7 in the regulation of EGFR expression in vitro and in vivo;Pretreatment of miR-7 mimics enhanced the PTX-mediated downregulation of epidermal growth factor receptor EGFR in NSCLC cells;We identified miR-7 as the important miRNA associated with estrogen actions in these cells and further examined the changes of estrogen-dependent EGFR expression by miR-7 in ER-positive or -negative breast carcinoma cell lines including MCF-7; We also evaluated the correlation between miR-7 and EGFR expression in breast carcinoma cells derived from 21 patients using laser capture microdissection combined with quantitative reverse transcriptase-PCR; miR-7 was reported to suppress epidermal growth factor receptor EGFR expression in several human malignancies; Transfection of miR-7 significantly suppressed EGFR mRNA levels in MCF-7 cells; We also evaluated the status of miR-7 in breast carcinoma tissues but the correlation between the status of miR-7 and EGFR in carcinoma cells isolated by laser capture microscopy was not detected; These results suggest that miR-7 may play a role in the development of resistance to endocrine therapy in breast cancer patients through regulating EGFR expression of carcinoma cells drug resistance;;;;;;cell migration;;;metastasis;malignant trasformation;;;drug resistance lung cancer;lung cancer;lung cancer;esophageal cancer;head and neck cancer;colorectal cancer;breast cancer;melanoma;ovarian cancer;ovarian cancer;glioblastoma;gastric cancer;lung squamous cell cancer;breast cancer hsa-miR-26a-5p EIF4E -0.929312251092796 7.48452512025337e-23 0.215561383917537 0.0161880121339536 mirMAP -0.127916150440724 0.00568370932706776 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.463931772449969 8.22426972811352e-05 2.53155404347689 3.55972608626733e-33 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.517618284983896 1.7081164049949e-07 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125b-5p EIF4EBP1 -0.353325281902983 0.00420243402705856 2.53155404347689 3.55972608626733e-33 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.501742159193023 1.20656087119386e-07 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-138-5p EIF4EBP1 -1.36574941930317 5.77867420411166e-08 2.53155404347689 3.55972608626733e-33 MirTarget;miRNATAP -0.166818004915786 0.000305831917547998 NA NA NA hsa-miR-146b-3p EIF4EBP1 -1.37101198101784 3.08716512915079e-22 2.53155404347689 3.55972608626733e-33 miRNATAP -0.601247387853773 3.417128517316e-15 NA NA NA hsa-miR-16-5p EPHA2 0.200674510503047 0.0593717079356147 0.0136421164335712 0.941935653428984 miRNAWalker2_validate -0.308843979978434 0.000654798960582822 NA NA NA hsa-miR-339-5p EPOR 0.695129802377533 1.42149990793285e-05 -1.60496300323115 1.63126028120025e-20 miRanda -0.129717740055682 0.0250777201046529 NA NA NA hsa-miR-429 EPOR 1.44127712764248 1.7824212712414e-11 -1.60496300323115 1.63126028120025e-20 miRanda -0.271050499876685 5.56052937872421e-11 NA NA NA hsa-miR-16-2-3p F2R 0.505774348451832 0.00083906759991608 -0.678959467930725 2.94007562121154e-05 mirMAP -0.462109900840278 2.29866283694741e-18 NA NA NA hsa-miR-20a-3p F2R 1.79890197957803 9.4283425564752e-24 -0.678959467930725 2.94007562121154e-05 MirTarget -0.202677996686127 3.40120904396872e-06 NA NA NA hsa-miR-335-3p F2R 0.462639143507351 0.00828753288457869 -0.678959467930725 2.94007562121154e-05 MirTarget -0.175159302891299 0.000235360026325098 NA NA NA hsa-miR-361-5p F2R -0.0236974652105824 0.799888526193556 -0.678959467930725 2.94007562121154e-05 miRanda -0.306134152929557 0.000789096058759108 NA NA NA hsa-miR-429 F2R 1.44127712764248 1.7824212712414e-11 -0.678959467930725 2.94007562121154e-05 miRanda -0.315844040020316 4.14840098530824e-18 NA NA NA hsa-miR-450b-5p F2R 1.40607004112146 2.03869814951451e-15 -0.678959467930725 2.94007562121154e-05 MirTarget;miRNATAP -0.108089360248443 0.0179435128387185 NA NA NA hsa-miR-582-5p F2R -0.0134667168827214 0.939685711149187 -0.678959467930725 2.94007562121154e-05 MirTarget -0.275403580823098 3.0164630662265e-09 NA NA NA hsa-miR-589-3p F2R 1.64129600791754 3.03909323325799e-16 -0.678959467930725 2.94007562121154e-05 MirTarget -0.219760807896331 2.93449602894464e-08 NA NA NA hsa-miR-590-3p F2R 0.9225805269779 6.0121446263776e-11 -0.678959467930725 2.94007562121154e-05 miRanda;mirMAP;miRNATAP -0.294753813313365 3.10701061701752e-07 NA NA NA hsa-miR-590-5p F2R 1.22823897140696 7.5538778278798e-17 -0.678959467930725 2.94007562121154e-05 miRanda -0.358926829557282 1.81581236304429e-11 NA NA NA hsa-miR-664a-3p F2R 0.131764091487629 0.242680083678861 -0.678959467930725 2.94007562121154e-05 mirMAP -0.196396965863936 0.00905144198293919 NA NA NA hsa-miR-25-3p FASLG 0.324190582599831 0.0073283146172755 -1.12329811940567 0.00013169131121756 miRNATAP -0.478034027306285 0.000138648559247416 NA NA NA hsa-miR-28-5p FASLG 0.189534080376749 0.0278108067630943 -1.12329811940567 0.00013169131121756 miRanda -0.775230655048351 1.32992334397002e-05 NA NA NA hsa-miR-324-5p FASLG 1.21634042749489 1.07503319022833e-13 -1.12329811940567 0.00013169131121756 miRanda -0.490090928003061 2.89691124227555e-08 NA NA NA hsa-miR-452-3p FASLG 1.41409839510389 1.17526115748788e-07 -1.12329811940567 0.00013169131121756 mirMAP -0.245480288318858 9.32211787086812e-06 NA NA NA hsa-miR-590-5p FASLG 1.22823897140696 7.5538778278798e-17 -1.12329811940567 0.00013169131121756 miRanda;miRNATAP -0.564791179261745 6.26595248119424e-09 NA NA NA hsa-miR-92a-3p FASLG 0.779792182638042 4.45572871602003e-09 -1.12329811940567 0.00013169131121756 miRNATAP -0.473703066942632 2.17543183957569e-05 NA NA NA hsa-miR-16-1-3p FGF1 -0.156899711138322 0.214597270113743 -0.803807667918799 0.000959201397574263 mirMAP -0.274871724205448 0.00590478341395721 NA NA NA hsa-miR-186-5p FGF1 0.439819047090102 6.33375570167175e-05 -0.803807667918799 0.000959201397574263 mirMAP -0.566118933887475 5.21196964347859e-07 NA NA NA hsa-miR-18a-5p FGF1 0.941249745535531 1.37246345065862e-06 -0.803807667918799 0.000959201397574263 MirTarget -0.411984359575161 2.84348523853536e-11 NA NA NA hsa-miR-217 FGF1 -0.501449190998853 0.0366805136279841 -0.803807667918799 0.000959201397574263 miRanda -0.110413770906996 0.0343007982127495 NA NA NA hsa-miR-222-5p FGF1 0.0443787380374991 0.777043899241278 -0.803807667918799 0.000959201397574263 MirTarget -0.284500003014338 0.000378115731444018 NA NA NA hsa-miR-26b-3p FGF1 0.157675322982898 0.216101238239109 -0.803807667918799 0.000959201397574263 MirTarget -0.242685102278008 0.0143423406819667 NA NA NA hsa-miR-28-5p FGF1 0.189534080376749 0.0278108067630943 -0.803807667918799 0.000959201397574263 miRanda -0.65194457773717 9.22433873491423e-06 NA NA NA hsa-miR-320a FGF1 0.25030125889857 0.0695425511666725 -0.803807667918799 0.000959201397574263 miRanda -0.184935843869383 0.0431751044971421 NA NA NA hsa-miR-320b FGF1 1.16387990475466 1.33051259463572e-10 -0.803807667918799 0.000959201397574263 miRanda -0.198088401427422 0.00330866365156435 NA NA NA hsa-miR-361-5p FGF1 -0.0236974652105824 0.799888526193556 -0.803807667918799 0.000959201397574263 miRanda -0.944271335501444 1.11120250458146e-12 NA NA NA hsa-miR-429 FGF1 1.44127712764248 1.7824212712414e-11 -0.803807667918799 0.000959201397574263 miRNATAP -0.372630991121943 1.76813146036454e-11 NA NA NA hsa-miR-484 FGF1 0.290563207815661 0.0187067524486015 -0.803807667918799 0.000959201397574263 MirTarget;PITA;miRNATAP -0.504958677865635 5.40672663329221e-07 NA NA NA hsa-miR-532-3p FGF1 0.62928908928122 1.1124581803679e-05 -0.803807667918799 0.000959201397574263 miRNATAP -0.467479365411119 4.77955827841895e-08 NA NA NA hsa-miR-550a-5p FGF1 0.762494609455337 2.22125274981609e-05 -0.803807667918799 0.000959201397574263 MirTarget -0.306977256831598 7.39120153233742e-06 NA NA NA hsa-miR-576-5p FGF1 0.993748428316612 2.24066125794743e-10 -0.803807667918799 0.000959201397574263 PITA;mirMAP -0.377094377026356 1.11098758970499e-06 NA NA NA hsa-miR-590-5p FGF1 1.22823897140696 7.5538778278798e-17 -0.803807667918799 0.000959201397574263 MirTarget;miRanda;miRNATAP -0.59248748591317 7.26260277206647e-14 NA NA NA hsa-miR-625-5p FGF1 1.04596928343988 2.07794141514857e-09 -0.803807667918799 0.000959201397574263 MirTarget -0.335090983897011 1.63465920866233e-06 NA NA NA hsa-miR-629-5p FGF1 0.896078284709513 1.3248439450822e-08 -0.803807667918799 0.000959201397574263 MirTarget -0.427315318242992 2.79746996685239e-08 NA NA NA hsa-miR-7-5p FGF1 2.15398885914606 3.95055061525106e-16 -0.803807667918799 0.000959201397574263 miRNAWalker2_validate -0.270212936692841 1.75157563224303e-08 NA NA NA hsa-miR-760 FGF1 2.46800133673516 9.92808266371112e-19 -0.803807667918799 0.000959201397574263 MirTarget;PITA;miRNATAP -0.182777666836633 2.63702205786189e-05 NA NA NA hsa-miR-944 FGF1 6.31318502943581 6.64615435406088e-56 -0.803807667918799 0.000959201397574263 mirMAP -0.127989929043177 1.42252047628133e-06 NA NA NA hsa-let-7a-5p FGF11 -0.644221394537031 9.97672106245846e-14 4.83588937994833 4.2603337403668e-63 TargetScan;mirMAP;miRNATAP -1.04276146244711 1.17188954054728e-07 NA NA NA hsa-let-7b-5p FGF11 -0.759197439090238 1.31014217546415e-10 4.83588937994833 4.2603337403668e-63 mirMAP;miRNATAP -0.558048231540803 0.000122187585566215 NA NA NA hsa-miR-10a-5p FGF11 -0.646485219146053 7.58185610123523e-08 4.83588937994833 4.2603337403668e-63 mirMAP -0.443066341529456 0.00214455730241402 NA NA NA hsa-miR-125a-5p FGF11 -0.463931772449969 8.22426972811352e-05 4.83588937994833 4.2603337403668e-63 mirMAP -0.429475961195591 0.00390131448828995 NA NA NA hsa-miR-125b-5p FGF11 -0.353325281902983 0.00420243402705856 4.83588937994833 4.2603337403668e-63 mirMAP -0.317865487729956 0.0261085323624779 NA NA NA hsa-miR-181a-5p FGF11 -1.31879909071317 2.04570351303734e-24 4.83588937994833 4.2603337403668e-63 mirMAP -1.0998906031576 1.68970871962393e-19 NA NA NA hsa-miR-181b-5p FGF11 -0.578702702808657 2.41220004393722e-05 4.83588937994833 4.2603337403668e-63 mirMAP -0.539992092841793 1.95858397642101e-05 NA NA NA hsa-miR-181c-5p FGF11 -1.36921360773694 5.61046203952059e-19 4.83588937994833 4.2603337403668e-63 mirMAP -0.887197519163875 1.81720315933016e-17 NA NA NA hsa-miR-195-5p FGF11 -1.62452829530841 2.94084397454942e-29 4.83588937994833 4.2603337403668e-63 mirMAP -0.895523843059036 1.14372505688891e-16 NA NA NA hsa-miR-326 FGF11 -2.468565451901 1.23182221778132e-19 4.83588937994833 4.2603337403668e-63 MirTarget;PITA;miRanda;miRNATAP -0.539355894554767 2.17850009409483e-20 NA NA NA hsa-miR-497-5p FGF11 -1.37093122385312 2.06413037457593e-23 4.83588937994833 4.2603337403668e-63 mirMAP -0.884028323373261 3.29116205909457e-14 NA NA NA hsa-let-7b-3p FGF12 -0.39527315467518 0.0023287663817318 1.23927669642344 0.000652347502720164 MirTarget -0.71481126780112 5.63648800433456e-07 NA NA NA hsa-miR-140-3p FGF12 -1.5688188604984 7.06409475976727e-33 1.23927669642344 0.000652347502720164 miRNATAP -0.360698981643382 0.00591532058462633 NA NA NA hsa-miR-142-5p FGF12 -0.0363288420100352 0.821716201807163 1.23927669642344 0.000652347502720164 miRNATAP -0.259805493986276 0.0261759246116664 NA NA NA hsa-miR-455-5p FGF12 -0.00576316954435274 0.972192681692013 1.23927669642344 0.000652347502720164 miRanda -0.365458626231908 0.00128126567485621 NA NA NA hsa-miR-511-5p FGF12 -1.56675999208301 5.80806146166175e-15 1.23927669642344 0.000652347502720164 MirTarget -0.202898523133242 0.0241656312133254 NA NA NA hsa-let-7a-3p FGF13 0.0442588630386531 0.71354010406076 -0.542765650170237 0.0848656276756844 MirTarget;miRNATAP -0.339063071273416 0.0121621020743755 NA NA NA hsa-miR-142-5p FGF13 -0.0363288420100352 0.821716201807163 -0.542765650170237 0.0848656276756844 PITA -0.202293434793532 0.0445721870450174 NA NA NA hsa-miR-214-5p FGF13 0.600651980931901 0.000147443056147678 -0.542765650170237 0.0848656276756844 miRNATAP -0.259683928207135 0.0105013814655496 NA NA NA hsa-miR-455-5p FGF13 -0.00576316954435274 0.972192681692013 -0.542765650170237 0.0848656276756844 PITA;miRanda -0.337501698038627 0.000548730959099388 NA NA NA hsa-miR-421 FGF14 1.16807936195133 1.4164941985739e-11 -2.44584955324211 1.68513385330936e-21 miRanda -0.605968065113302 1.54027102796857e-15 NA NA NA hsa-miR-590-3p FGF14 0.9225805269779 6.0121446263776e-11 -2.44584955324211 1.68513385330936e-21 miRanda -0.688727913537769 2.13160182268443e-13 NA NA NA hsa-miR-96-5p FGF14 2.81159638603625 3.72452637775194e-34 -2.44584955324211 1.68513385330936e-21 TargetScan -0.508575761832849 1.03766814681354e-22 NA NA NA hsa-miR-103a-3p FGF18 0.227460152182967 0.0312044839849861 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.434831852795922 0.00827296458772374 NA NA NA hsa-miR-129-5p FGF18 2.0409652261565 1.19491474689015e-07 -3.38204125847467 2.19025396618518e-27 miRanda -0.135142636215021 0.00199864115450551 NA NA NA hsa-miR-15b-5p FGF18 0.575042920336974 9.75508983626876e-06 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.72549893490805 2.13785925359558e-08 NA NA NA hsa-miR-16-5p FGF18 0.200674510503047 0.0593717079356147 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.485166244909016 0.00295272407848591 NA NA NA hsa-miR-200b-3p FGF18 1.24269422431788 9.2707509169586e-11 -3.38204125847467 2.19025396618518e-27 TargetScan -0.465620384751611 6.52229603419319e-08 NA NA NA hsa-miR-200c-3p FGF18 1.44830286955223 1.39903737828795e-22 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.955429027362092 5.64994690085404e-20 NA NA NA hsa-miR-21-5p FGF18 1.07034578283768 3.39448630342548e-28 -3.38204125847467 2.19025396618518e-27 miRNATAP -1.12504394791223 3.44112181741906e-12 NA NA NA hsa-miR-362-5p FGF18 0.26329593259106 0.182949931130249 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.195190495286036 0.0251445670689027 NA NA NA hsa-miR-421 FGF18 1.16807936195133 1.4164941985739e-11 -3.38204125847467 2.19025396618518e-27 miRanda -0.51509297804738 8.17021347199018e-08 NA NA NA hsa-miR-424-5p FGF18 1.50572404087407 4.24425395615445e-20 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.590993056124729 1.50424676030924e-09 NA NA NA hsa-miR-429 FGF18 1.44127712764248 1.7824212712414e-11 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.42493056775033 3.13790293030212e-08 NA NA NA hsa-miR-505-3p FGF18 1.02991829785126 3.27959895590399e-13 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.62469359378075 8.28427968906996e-08 NA NA NA hsa-miR-590-5p FGF18 1.22823897140696 7.5538778278798e-17 -3.38204125847467 2.19025396618518e-27 miRanda;miRNATAP -0.802042545552057 1.67770401528765e-13 NA NA NA hsa-miR-9-5p FGF18 4.97757576742384 8.49748323724349e-41 -3.38204125847467 2.19025396618518e-27 miRNATAP -0.34449938466098 2.34048505920633e-18 NA NA NA hsa-miR-193a-3p FGF19 -0.399504718785393 0.0108866663328791 3.65972754927894 3.1585661643951e-09 miRanda -0.443444683895999 0.032001965809606 NA NA NA hsa-let-7a-3p FGF2 0.0442588630386531 0.71354010406076 -1.90359848903339 4.66702234483423e-16 mirMAP -0.3226379044647 0.00203553144905968 NA NA NA hsa-miR-1226-3p FGF2 1.27791843537411 2.95203258399206e-10 -1.90359848903339 4.66702234483423e-16 MirTarget -0.24232446696556 7.62133815851277e-05 NA NA NA hsa-miR-15b-3p FGF2 0.720785796663996 5.61234325663636e-07 -1.90359848903339 4.66702234483423e-16 mirMAP -0.221697705174509 0.00989009214375752 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.575042920336974 9.75508983626876e-06 -1.90359848903339 4.66702234483423e-16 MirTarget;miRNATAP -0.193059602875741 0.0441033518369031 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 0.505774348451832 0.00083906759991608 -1.90359848903339 4.66702234483423e-16 mirMAP -0.199608961207673 0.0154939217193543 NA NA NA hsa-miR-16-5p FGF2 0.200674510503047 0.0593717079356147 -1.90359848903339 4.66702234483423e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.243608100635232 0.0407167939530058 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-186-5p FGF2 0.439819047090102 6.33375570167175e-05 -1.90359848903339 4.66702234483423e-16 miRNAWalker2_validate;mirMAP -0.275143888109429 0.0158281715221859 NA NA NA hsa-miR-19b-1-5p FGF2 0.550369246540305 0.000830309981399621 -1.90359848903339 4.66702234483423e-16 mirMAP -0.265218995085428 0.00043781058968663 NA NA NA hsa-miR-200b-3p FGF2 1.24269422431788 9.2707509169586e-11 -1.90359848903339 4.66702234483423e-16 mirMAP -0.24582470956327 0.000101289672856356 NA NA NA hsa-miR-200c-3p FGF2 1.44830286955223 1.39903737828795e-22 -1.90359848903339 4.66702234483423e-16 mirMAP -0.411661657878751 1.71091372784518e-07 NA NA NA hsa-miR-20a-3p FGF2 1.79890197957803 9.4283425564752e-24 -1.90359848903339 4.66702234483423e-16 mirMAP -0.337724988710269 1.84862518525284e-07 NA NA NA hsa-miR-21-3p FGF2 0.924068840797428 6.92652443457631e-12 -1.90359848903339 4.66702234483423e-16 mirMAP -0.280003222074434 0.00197697811164829 NA NA NA hsa-miR-21-5p FGF2 1.07034578283768 3.39448630342548e-28 -1.90359848903339 4.66702234483423e-16 mirMAP -0.386746026497314 0.00133346271635781 NA NA NA hsa-miR-222-3p FGF2 0.650386170149202 1.83345699702669e-06 -1.90359848903339 4.66702234483423e-16 mirMAP -0.390844439459852 1.50702742678883e-05 NA NA NA hsa-miR-3682-3p FGF2 1.00929490472499 5.45439049842858e-08 -1.90359848903339 4.66702234483423e-16 mirMAP -0.214565817760554 0.00203164488299641 NA NA NA hsa-miR-424-5p FGF2 1.50572404087407 4.24425395615445e-20 -1.90359848903339 4.66702234483423e-16 MirTarget;miRNATAP -0.255525955565581 0.000403619937391597 NA NA NA hsa-miR-429 FGF2 1.44127712764248 1.7824212712414e-11 -1.90359848903339 4.66702234483423e-16 mirMAP -0.243597303424882 1.49956162605943e-05 NA NA NA hsa-miR-450b-5p FGF2 1.40607004112146 2.03869814951451e-15 -1.90359848903339 4.66702234483423e-16 mirMAP -0.146213767426093 0.0317626479616778 NA NA NA hsa-miR-452-5p FGF2 1.08242667876786 2.34127628858457e-06 -1.90359848903339 4.66702234483423e-16 mirMAP -0.170935702718281 0.00145327436497231 NA NA NA hsa-miR-503-5p FGF2 2.44514033793504 1.41589743344165e-28 -1.90359848903339 4.66702234483423e-16 miRNAWalker2_validate -0.235763839189878 5.98529938953194e-06 NA NA NA hsa-miR-539-5p FGF2 1.67998239253065 8.87745362575108e-13 -1.90359848903339 4.66702234483423e-16 mirMAP -0.122795547839805 0.0176610946380671 NA NA NA hsa-miR-589-3p FGF2 1.64129600791754 3.03909323325799e-16 -1.90359848903339 4.66702234483423e-16 mirMAP -0.266875768716176 7.17361178587384e-06 NA NA NA hsa-miR-590-3p FGF2 0.9225805269779 6.0121446263776e-11 -1.90359848903339 4.66702234483423e-16 miRanda;mirMAP -0.246485060166955 0.00454201202526571 NA NA NA hsa-miR-590-5p FGF2 1.22823897140696 7.5538778278798e-17 -1.90359848903339 4.66702234483423e-16 miRanda;mirMAP -0.337815400399506 3.06361662131292e-05 NA NA NA hsa-miR-92a-3p FGF2 0.779792182638042 4.45572871602003e-09 -1.90359848903339 4.66702234483423e-16 miRNAWalker2_validate -0.325652330195421 0.000420833710597673 NA NA NA hsa-miR-93-3p FGF2 1.87333981556813 3.67417899907584e-29 -1.90359848903339 4.66702234483423e-16 mirMAP -0.345426068126246 4.50629174898313e-07 NA NA NA hsa-miR-944 FGF2 6.31318502943581 6.64615435406088e-56 -1.90359848903339 4.66702234483423e-16 MirTarget -0.108232046885179 4.75159118166075e-05 NA NA NA hsa-miR-126-5p FGF5 -1.94634635849451 2.4038399235921e-37 2.24964602256054 3.03524629952303e-08 mirMAP -0.795967186037914 9.97083497691505e-11 NA NA NA hsa-miR-16-1-3p FGF5 -0.156899711138322 0.214597270113743 2.24964602256054 3.03524629952303e-08 mirMAP -0.616813418432371 0.000244783972164218 NA NA NA hsa-miR-3065-5p FGF5 -0.963317497666877 0.000100334146005009 2.24964602256054 3.03524629952303e-08 mirMAP -0.281434997699528 0.000962520653306322 NA NA NA hsa-miR-30a-5p FGF5 -2.98793938555326 1.93840183838367e-49 2.24964602256054 3.03524629952303e-08 mirMAP -0.507224755913236 1.79948656355519e-08 NA NA NA hsa-miR-30b-5p FGF5 -1.50117013761001 1.78247435398346e-20 2.24964602256054 3.03524629952303e-08 mirMAP -0.708865061778368 6.53605002754339e-09 NA NA NA hsa-miR-30c-5p FGF5 -0.426804145561029 0.00403132854321475 2.24964602256054 3.03524629952303e-08 mirMAP -0.478507539400267 0.000776644879440146 NA NA NA hsa-miR-30d-5p FGF5 -2.06908130936031 2.23574479943606e-47 2.24964602256054 3.03524629952303e-08 mirMAP -0.953449245455394 4.4311742045008e-14 NA NA NA hsa-miR-30e-5p FGF5 0.186424244301373 0.077486249643257 2.24964602256054 3.03524629952303e-08 mirMAP -0.676682007365614 0.000831256808730716 NA NA NA hsa-miR-338-3p FGF5 -2.39495045399875 3.50911311863594e-28 2.24964602256054 3.03524629952303e-08 miRanda -0.496491613162528 2.24864386390144e-08 NA NA NA hsa-miR-3607-3p FGF5 0.797258097957342 0.000266170796527225 2.24964602256054 3.03524629952303e-08 miRNATAP -0.196849601197031 0.0410312379131875 NA NA NA hsa-miR-374a-5p FGF5 -0.371522195407694 3.64288279697975e-05 2.24964602256054 3.03524629952303e-08 mirMAP -0.950399770755691 5.68430201643571e-05 NA NA NA hsa-miR-374b-5p FGF5 -0.490675710652087 1.35508117735881e-06 2.24964602256054 3.03524629952303e-08 mirMAP -0.781869954517934 0.000165056361093051 NA NA NA hsa-miR-486-5p FGF5 -3.31030668897609 1.04617579408648e-33 2.24964602256054 3.03524629952303e-08 miRanda -0.306456761093896 1.19556225430399e-05 NA NA NA hsa-miR-582-5p FGF5 -0.0134667168827214 0.939685711149187 2.24964602256054 3.03524629952303e-08 mirMAP -0.255455256264997 0.0326894538871036 NA NA NA hsa-let-7a-3p FGF7 0.0442588630386531 0.71354010406076 -2.21075820985081 1.35518492250444e-20 MirTarget;miRNATAP -0.397147964242244 0.000208971034498052 NA NA NA hsa-miR-15a-5p FGF7 -0.24629041301676 0.0253630661893983 -2.21075820985081 1.35518492250444e-20 miRTarBase;miRNATAP -0.242675389243248 0.0395236088884662 NA NA NA hsa-miR-15b-5p FGF7 0.575042920336974 9.75508983626876e-06 -2.21075820985081 1.35518492250444e-20 miRNATAP -0.841496141426109 2.70846207171414e-19 NA NA NA hsa-miR-16-1-3p FGF7 -0.156899711138322 0.214597270113743 -2.21075820985081 1.35518492250444e-20 mirMAP -0.228849835459519 0.0255915424518464 NA NA NA hsa-miR-16-2-3p FGF7 0.505774348451832 0.00083906759991608 -2.21075820985081 1.35518492250444e-20 mirMAP -0.666595843240901 2.57678215403509e-16 NA NA NA hsa-miR-16-5p FGF7 0.200674510503047 0.0593717079356147 -2.21075820985081 1.35518492250444e-20 miRNATAP -0.614549245033559 3.40773527165863e-07 NA NA NA hsa-miR-18a-3p FGF7 2.05585109851169 1.40576069637563e-20 -2.21075820985081 1.35518492250444e-20 MirTarget -0.449583329047483 2.21810690137786e-17 NA NA NA hsa-miR-20a-5p FGF7 0.758237786270513 3.11867983980517e-05 -2.21075820985081 1.35518492250444e-20 miRNAWalker2_validate -0.426441924895942 4.79165251749319e-10 NA NA NA hsa-miR-27a-3p FGF7 0.140284703630369 0.213001086994521 -2.21075820985081 1.35518492250444e-20 MirTarget -0.728605348349002 9.94278196481313e-11 NA NA NA hsa-miR-27b-3p FGF7 0.0774984459252845 0.455541249499373 -2.21075820985081 1.35518492250444e-20 MirTarget -0.58374984977508 2.58934275027757e-06 NA NA NA hsa-miR-31-5p FGF7 4.55834486468821 4.36738083192596e-25 -2.21075820985081 1.35518492250444e-20 MirTarget -0.156434146149508 2.74449001106312e-08 NA NA NA hsa-miR-320a FGF7 0.25030125889857 0.0695425511666725 -2.21075820985081 1.35518492250444e-20 miRanda -0.316652526259548 0.000687968195254414 NA NA NA hsa-miR-320b FGF7 1.16387990475466 1.33051259463572e-10 -2.21075820985081 1.35518492250444e-20 miRanda -0.346256367994643 4.06442432391084e-07 NA NA NA hsa-miR-33a-3p FGF7 0.540032749009224 0.00270907254062352 -2.21075820985081 1.35518492250444e-20 mirMAP -0.425645266950075 1.62951245044949e-09 NA NA NA hsa-miR-3607-3p FGF7 0.797258097957342 0.000266170796527225 -2.21075820985081 1.35518492250444e-20 mirMAP -0.188697892010947 0.00117582024699887 NA NA NA hsa-miR-361-5p FGF7 -0.0236974652105824 0.799888526193556 -2.21075820985081 1.35518492250444e-20 PITA;miRanda;miRNATAP -0.314386409272139 0.0248661363726735 NA NA NA hsa-miR-421 FGF7 1.16807936195133 1.4164941985739e-11 -2.21075820985081 1.35518492250444e-20 miRanda -0.462895944240958 7.4222262397774e-11 NA NA NA hsa-miR-424-5p FGF7 1.50572404087407 4.24425395615445e-20 -2.21075820985081 1.35518492250444e-20 miRNATAP -0.453615620890103 4.94509100560254e-10 NA NA NA hsa-miR-429 FGF7 1.44127712764248 1.7824212712414e-11 -2.21075820985081 1.35518492250444e-20 miRNATAP -0.452426838648236 7.16022344258991e-16 NA NA NA hsa-miR-452-5p FGF7 1.08242667876786 2.34127628858457e-06 -2.21075820985081 1.35518492250444e-20 mirMAP -0.356614721723903 3.80830434832222e-11 NA NA NA hsa-miR-455-3p FGF7 2.18142848948175 2.92546018153478e-26 -2.21075820985081 1.35518492250444e-20 PITA;miRNATAP -0.393469837858399 3.65632880340095e-12 NA NA NA hsa-miR-501-5p FGF7 0.316742767698094 0.0632047358679198 -2.21075820985081 1.35518492250444e-20 PITA;mirMAP -0.20016628604248 0.00805006395768163 NA NA NA hsa-miR-577 FGF7 3.5197399300515 1.67960995324817e-16 -2.21075820985081 1.35518492250444e-20 PITA;mirMAP -0.204683551151555 8.64022297617875e-11 NA NA NA hsa-miR-590-3p FGF7 0.9225805269779 6.0121446263776e-11 -2.21075820985081 1.35518492250444e-20 PITA;miRanda;mirMAP;miRNATAP -0.566213737265747 8.53743758568638e-11 NA NA NA hsa-miR-590-5p FGF7 1.22823897140696 7.5538778278798e-17 -2.21075820985081 1.35518492250444e-20 PITA;miRanda -0.661971249257963 2.07707001004348e-16 NA NA NA hsa-miR-616-5p FGF7 2.3596511369846 3.26881700557061e-22 -2.21075820985081 1.35518492250444e-20 mirMAP -0.369407207629029 1.07055084744996e-13 NA NA NA hsa-miR-7-1-3p FGF7 1.23074353429962 9.62692371802457e-18 -2.21075820985081 1.35518492250444e-20 mirMAP -0.681730470344241 1.39978786278262e-16 NA NA NA hsa-miR-708-3p FGF7 2.92078833427619 3.23244846700224e-40 -2.21075820985081 1.35518492250444e-20 mirMAP -0.419069614587229 6.77945987483672e-17 NA NA NA hsa-miR-944 FGF7 6.31318502943581 6.64615435406088e-56 -2.21075820985081 1.35518492250444e-20 mirMAP -0.277090976739154 2.89190118747767e-27 NA NA NA hsa-miR-155-5p FGF9 0.459859353454849 0.00515473360914761 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.209064624841525 0.0445169442970683 NA NA NA hsa-miR-15b-5p FGF9 0.575042920336974 9.75508983626876e-06 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.471634394343207 0.000294816671228474 NA NA NA hsa-miR-16-2-3p FGF9 0.505774348451832 0.00083906759991608 -2.85567913969991 2.22155757077547e-19 mirMAP -0.428639464378607 0.000130623843378493 NA NA NA hsa-miR-182-5p FGF9 2.16789823981744 5.64205069446407e-26 -2.85567913969991 2.22155757077547e-19 miRTarBase;miRNATAP -0.448910535883775 3.65999081068968e-09 NA NA NA hsa-miR-183-5p FGF9 2.81472476144496 4.67808720273896e-39 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.454807522410285 6.74331557916684e-11 NA NA NA hsa-miR-205-5p FGF9 7.4255450988826 2.64056553520099e-76 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.344028848578264 1.40573109470382e-26 NA NA NA hsa-miR-212-3p FGF9 0.652267799788663 3.93810796447291e-05 -2.85567913969991 2.22155757077547e-19 mirMAP -0.367721160213997 0.000588194431336497 NA NA NA hsa-miR-221-5p FGF9 0.312129280210106 0.142808962347635 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.230145773232842 0.00426360261523365 NA NA NA hsa-miR-320a FGF9 0.25030125889857 0.0695425511666725 -2.85567913969991 2.22155757077547e-19 mirMAP;miRNATAP -0.354523587642026 0.00438268502454422 NA NA NA hsa-miR-320b FGF9 1.16387990475466 1.33051259463572e-10 -2.85567913969991 2.22155757077547e-19 mirMAP;miRNATAP -0.270304405747163 0.00329729817613778 NA NA NA hsa-miR-3607-3p FGF9 0.797258097957342 0.000266170796527225 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.155618032903247 0.0452769670318511 NA NA NA hsa-miR-424-5p FGF9 1.50572404087407 4.24425395615445e-20 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.579527061964543 2.52825444584062e-09 NA NA NA hsa-miR-429 FGF9 1.44127712764248 1.7824212712414e-11 -2.85567913969991 2.22155757077547e-19 miRanda -0.317320287438301 3.7729669552222e-05 NA NA NA hsa-miR-450b-5p FGF9 1.40607004112146 2.03869814951451e-15 -2.85567913969991 2.22155757077547e-19 mirMAP;miRNATAP -0.271183848024427 0.00348224934567014 NA NA NA hsa-miR-455-5p FGF9 -0.00576316954435274 0.972192681692013 -2.85567913969991 2.22155757077547e-19 miRanda -0.400582251073413 0.000104459782273913 NA NA NA hsa-miR-500a-5p FGF9 0.202654345352218 0.2571507084955 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.234222303739153 0.0145315740496155 NA NA NA hsa-miR-590-3p FGF9 0.9225805269779 6.0121446263776e-11 -2.85567913969991 2.22155757077547e-19 miRanda;mirMAP -0.534599443965214 5.6051123602389e-06 NA NA NA hsa-miR-590-5p FGF9 1.22823897140696 7.5538778278798e-17 -2.85567913969991 2.22155757077547e-19 miRanda -0.533794165269947 1.30716337233392e-06 NA NA NA hsa-miR-744-3p FGF9 2.30146344978714 7.34748315334014e-24 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.279708952243619 6.0167428305214e-05 NA NA NA hsa-miR-9-5p FGF9 4.97757576742384 8.49748323724349e-41 -2.85567913969991 2.22155757077547e-19 miRNATAP -0.232152795760746 8.26054961883623e-09 NA NA NA hsa-miR-944 FGF9 6.31318502943581 6.64615435406088e-56 -2.85567913969991 2.22155757077547e-19 mirMAP -0.343915732646226 1.92132266976351e-23 NA NA NA hsa-miR-96-5p FGF9 2.81159638603625 3.72452637775194e-34 -2.85567913969991 2.22155757077547e-19 TargetScan;miRNATAP -0.454599083489383 4.43715833820147e-12 NA NA NA hsa-miR-135b-5p FGFR1 1.57294269928689 3.57109531929976e-09 -0.606354578302531 0.00407205873065966 mirMAP -0.117741134478023 0.00304209843009325 NA NA NA hsa-miR-16-5p FGFR1 0.200674510503047 0.0593717079356147 -0.606354578302531 0.00407205873065966 miRTarBase;miRNATAP -0.233749094426019 0.0234644892747815 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-200a-5p FGFR1 1.8625149656411 2.00715507468494e-20 -0.606354578302531 0.00407205873065966 mirMAP -0.10611520377654 0.0382250868125703 NA NA NA hsa-miR-200b-5p FGFR1 2.1000866113144 2.48742582531618e-25 -0.606354578302531 0.00407205873065966 mirMAP -0.104473834310471 0.037696867645325 NA NA NA hsa-miR-2355-5p FGFR1 -0.168057176675532 0.244338435341361 -0.606354578302531 0.00407205873065966 mirMAP -0.152372899799417 0.0440247310141018 NA NA NA hsa-miR-455-5p FGFR1 -0.00576316954435274 0.972192681692013 -0.606354578302531 0.00407205873065966 miRanda -0.140726538768423 0.0328833433592377 NA NA NA hsa-miR-146b-5p FGFR2 -0.432155779449763 0.00591587599739451 0.254756283883074 0.321794890555937 miRanda -0.195688410417805 0.0195630552899093 NA NA NA hsa-miR-193a-3p FGFR2 -0.399504718785393 0.0108866663328791 0.254756283883074 0.321794890555937 miRanda -0.315806357094325 0.000157720228672615 NA NA NA hsa-miR-326 FGFR2 -2.468565451901 1.23182221778132e-19 0.254756283883074 0.321794890555937 miRanda -0.159020204225193 0.000520448941441252 NA NA NA hsa-miR-330-5p FGFR2 0.168243129357275 0.239196436552122 0.254756283883074 0.321794890555937 miRanda -0.258947024425215 0.00509226699011335 NA NA NA hsa-miR-100-5p FGFR3 -1.55858901419153 8.83648748818133e-17 1.38216457222483 3.3008404905658e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.325919782254304 3.14530714722707e-05 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-194-5p FGFR3 -0.249320646823728 0.0887475457808623 1.38216457222483 3.3008404905658e-06 miRNATAP -0.341938688256053 0.0011723692624797 NA NA NA hsa-miR-214-3p FGFR4 0.577119051151258 0.00273591975247163 -3.60515999180248 2.90921269595812e-37 mirMAP -0.184578271782485 0.0267866581904434 NA NA NA hsa-miR-106a-5p FLT1 0.887689359198128 2.74215376899957e-05 -1.26159956142028 2.46560967965933e-17 MirTarget;miRNATAP -0.25291935882516 3.03330848196389e-12 NA NA NA hsa-miR-106b-5p FLT1 0.768146314773296 1.22330832259683e-08 -1.26159956142028 2.46560967965933e-17 MirTarget;miRNATAP -0.419855985414766 1.01730392084261e-13 NA NA NA hsa-miR-149-5p FLT1 3.1548412914629 4.44598605668453e-31 -1.26159956142028 2.46560967965933e-17 MirTarget -0.201012376185716 9.58253965440941e-15 NA NA NA hsa-miR-17-5p FLT1 1.27106228457264 5.91314767482551e-14 -1.26159956142028 2.46560967965933e-17 MirTarget;TargetScan;miRNATAP -0.318339044055929 6.06635621680192e-13 NA NA NA hsa-miR-186-5p FLT1 0.439819047090102 6.33375570167175e-05 -1.26159956142028 2.46560967965933e-17 mirMAP -0.243234143377275 0.000778085532741613 NA NA NA hsa-miR-19a-3p FLT1 1.29022522620563 7.13786738838458e-11 -1.26159956142028 2.46560967965933e-17 MirTarget -0.265601195242945 3.44648758783491e-12 NA NA NA hsa-miR-19b-3p FLT1 0.786722036548617 1.29623163115342e-06 -1.26159956142028 2.46560967965933e-17 MirTarget -0.301596868550259 2.00965779285754e-10 NA NA NA hsa-miR-200b-3p FLT1 1.24269422431788 9.2707509169586e-11 -1.26159956142028 2.46560967965933e-17 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.26848644621907 1.03098354083825e-11 21115742 Forced miR-200 expression suppressed Flt1 levels in metastasis-prone lung adenocarcinoma cells derived from K-ras/p53-mutant mice and negatively regulated the Flt1 3'-UTR in reporter assays; We conclude that miR-200 suppresses lung tumorigenesis by targeting Flt1 metastasis;tumorigenesis lung cancer hsa-miR-200c-3p FLT1 1.44830286955223 1.39903737828795e-22 -1.26159956142028 2.46560967965933e-17 miRNAWalker2_validate;miRTarBase;MirTarget -0.369413301659711 6.1400469351085e-14 NA NA NA hsa-miR-20a-5p FLT1 0.758237786270513 3.11867983980517e-05 -1.26159956142028 2.46560967965933e-17 MirTarget;miRNATAP -0.235452691407864 3.5571260184517e-08 NA NA NA hsa-miR-20b-5p FLT1 0.396943783991848 0.194012869265072 -1.26159956142028 2.46560967965933e-17 MirTarget;miRNATAP -0.112223603498437 1.37800727889943e-05 NA NA NA hsa-miR-22-5p FLT1 0.572104677310157 8.96288502279847e-06 -1.26159956142028 2.46560967965933e-17 MirTarget -0.256670841031063 2.67202971917496e-05 NA NA NA hsa-miR-224-5p FLT1 2.66023106212545 6.37784852724057e-19 -1.26159956142028 2.46560967965933e-17 mirMAP -0.12311423230367 8.338113475575e-07 NA NA NA hsa-miR-24-3p FLT1 0.272730498465254 0.0053154135686548 -1.26159956142028 2.46560967965933e-17 miRNATAP -0.255991842344828 0.00184494963129975 NA NA NA hsa-miR-28-5p FLT1 0.189534080376749 0.0278108067630943 -1.26159956142028 2.46560967965933e-17 miRanda -0.27964730133264 0.00297227512470854 NA NA NA hsa-miR-3200-3p FLT1 1.96851854609803 5.39282273222562e-13 -1.26159956142028 2.46560967965933e-17 MirTarget -0.12495878185374 8.46713100167128e-06 NA NA NA hsa-miR-335-3p FLT1 0.462639143507351 0.00828753288457869 -1.26159956142028 2.46560967965933e-17 mirMAP -0.146530156580615 0.00121687144982812 NA NA NA hsa-miR-339-5p FLT1 0.695129802377533 1.42149990793285e-05 -1.26159956142028 2.46560967965933e-17 miRanda -0.284169544921183 4.54911235655155e-09 NA NA NA hsa-miR-378a-3p FLT1 0.590540647783337 0.000399996797136959 -1.26159956142028 2.46560967965933e-17 MirTarget -0.215524341239212 4.76964844240705e-06 NA NA NA hsa-miR-421 FLT1 1.16807936195133 1.4164941985739e-11 -1.26159956142028 2.46560967965933e-17 miRanda -0.251703872570972 1.4237345955956e-08 NA NA NA hsa-miR-429 FLT1 1.44127712764248 1.7824212712414e-11 -1.26159956142028 2.46560967965933e-17 MirTarget;miRanda;miRNATAP -0.263520335453351 4.8704934451731e-14 NA NA NA hsa-miR-501-5p FLT1 0.316742767698094 0.0632047358679198 -1.26159956142028 2.46560967965933e-17 mirMAP -0.159430401358541 0.000642159963245052 NA NA NA hsa-miR-505-5p FLT1 1.28871267080216 1.00459615050289e-12 -1.26159956142028 2.46560967965933e-17 MirTarget -0.216716803519543 2.84984669071323e-07 NA NA NA hsa-miR-576-5p FLT1 0.993748428316612 2.24066125794743e-10 -1.26159956142028 2.46560967965933e-17 mirMAP -0.240895505394456 9.8372507180894e-07 NA NA NA hsa-miR-590-3p FLT1 0.9225805269779 6.0121446263776e-11 -1.26159956142028 2.46560967965933e-17 miRanda -0.324120540358804 2.45215468931744e-09 NA NA NA hsa-miR-616-5p FLT1 2.3596511369846 3.26881700557061e-22 -1.26159956142028 2.46560967965933e-17 mirMAP -0.187167959023165 2.0333922988646e-09 NA NA NA hsa-miR-629-3p FLT1 2.47046856327102 4.17622167602811e-39 -1.26159956142028 2.46560967965933e-17 MirTarget -0.214562431126539 8.7409589492491e-09 NA NA NA hsa-miR-708-5p FLT1 3.70808687333578 5.51249219545358e-54 -1.26159956142028 2.46560967965933e-17 MirTarget -0.231718909373306 3.38803114130074e-17 NA NA NA hsa-miR-744-3p FLT1 2.30146344978714 7.34748315334014e-24 -1.26159956142028 2.46560967965933e-17 MirTarget -0.134810052369626 3.29753607733606e-05 NA NA NA hsa-miR-877-5p FLT1 2.90093737151303 2.52134268016683e-35 -1.26159956142028 2.46560967965933e-17 MirTarget -0.207185356535372 1.55654922303505e-11 NA NA NA hsa-miR-93-5p FLT1 1.27151657903037 1.96654008726155e-14 -1.26159956142028 2.46560967965933e-17 MirTarget;miRNATAP -0.296110839271159 6.02838511665481e-11 NA NA NA hsa-miR-944 FLT1 6.31318502943581 6.64615435406088e-56 -1.26159956142028 2.46560967965933e-17 mirMAP;miRNATAP -0.137490046214215 4.43023634282901e-17 NA NA NA hsa-miR-542-3p FLT3 0.0944680117124008 0.47453779285373 -2.02578693977051 1.49796831226618e-10 miRanda -0.270990321426026 0.0326750372143962 NA NA NA hsa-miR-590-3p FLT3 0.9225805269779 6.0121446263776e-11 -2.02578693977051 1.49796831226618e-10 PITA;miRanda;mirMAP;miRNATAP -0.278910335996488 0.0157574177721635 NA NA NA hsa-miR-331-3p FLT4 0.954925871149262 2.04897100127988e-09 -2.5014752445639 3.02123268434372e-38 miRNAWalker2_validate -0.292965839479284 1.28305071321035e-05 NA NA NA hsa-miR-369-3p FLT4 1.01732933007745 5.62255655622001e-06 -2.5014752445639 3.02123268434372e-38 mirMAP -0.120692163491368 0.0131505670628468 NA NA NA hsa-miR-429 FLT4 1.44127712764248 1.7824212712414e-11 -2.5014752445639 3.02123268434372e-38 miRanda;miRNATAP -0.427595042535147 2.22474726963021e-19 NA NA NA hsa-let-7g-5p FN1 0.0868874053614963 0.322163222422263 -1.19874467984738 6.57552031124879e-06 miRTarBase -0.703342584063067 9.67119063497242e-06 NA NA NA hsa-miR-1271-5p FN1 1.0987045785026 1.5617128114028e-09 -1.19874467984738 6.57552031124879e-06 MirTarget -0.298751732594762 5.01608893857458e-05 NA NA NA hsa-miR-16-1-3p FN1 -0.156899711138322 0.214597270113743 -1.19874467984738 6.57552031124879e-06 mirMAP -0.522608129791845 1.51523251221631e-06 NA NA NA hsa-miR-200b-3p FN1 1.24269422431788 9.2707509169586e-11 -1.19874467984738 6.57552031124879e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.588685636679316 1.38686079988362e-18 24391862 In contrast mesenchymal markers fibronectin and vimentin were significantly downregulated by miR-200 b prostate cancer hsa-miR-200c-3p FN1 1.44830286955223 1.39903737828795e-22 -1.19874467984738 6.57552031124879e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.702919481720314 8.31185535749044e-17 NA NA NA hsa-miR-26b-5p FN1 -0.0183893267106221 0.882303333465809 -1.19874467984738 6.57552031124879e-06 miRNAWalker2_validate -0.381285512382259 0.000634517561708066 NA NA NA hsa-miR-27a-3p FN1 0.140284703630369 0.213001086994521 -1.19874467984738 6.57552031124879e-06 MirTarget -0.476220523859307 0.000107897694878589 NA NA NA hsa-miR-27b-3p FN1 0.0774984459252845 0.455541249499373 -1.19874467984738 6.57552031124879e-06 MirTarget -0.653894160284206 8.86324810183281e-07 NA NA NA hsa-miR-320a FN1 0.25030125889857 0.0695425511666725 -1.19874467984738 6.57552031124879e-06 miRanda -0.397337356782234 6.84272798332859e-05 NA NA NA hsa-miR-320b FN1 1.16387990475466 1.33051259463572e-10 -1.19874467984738 6.57552031124879e-06 miRanda -0.249017302963394 0.000767378808397181 NA NA NA hsa-miR-33a-3p FN1 0.540032749009224 0.00270907254062352 -1.19874467984738 6.57552031124879e-06 mirMAP -0.462132436825698 1.01155393398501e-09 NA NA NA hsa-miR-429 FN1 1.44127712764248 1.7824212712414e-11 -1.19874467984738 6.57552031124879e-06 MirTarget;PITA;miRanda;miRNATAP -0.513527330114861 9.20922473094601e-18 NA NA NA hsa-miR-590-3p FN1 0.9225805269779 6.0121446263776e-11 -1.19874467984738 6.57552031124879e-06 miRanda;mirMAP -0.632962956125778 1.19515732633815e-11 NA NA NA hsa-miR-944 FN1 6.31318502943581 6.64615435406088e-56 -1.19874467984738 6.57552031124879e-06 mirMAP -0.227601408463455 1.16692158891027e-15 NA NA NA hsa-miR-96-5p FN1 2.81159638603625 3.72452637775194e-34 -1.19874467984738 6.57552031124879e-06 MirTarget;TargetScan -0.559647619125647 1.3972017327916e-28 NA NA NA hsa-miR-29b-3p FOXO3 -0.0219237619606503 0.883966228726957 -0.33711505433025 0.00106655246299466 miRNATAP -0.115585182383438 0.00105095969019734 NA NA NA hsa-miR-590-3p GHR 0.9225805269779 6.0121446263776e-11 -0.686756533592704 0.0440721975484417 mirMAP -0.333294580722568 0.00608071034166515 NA NA NA hsa-miR-7-1-3p GHR 1.23074353429962 9.62692371802457e-18 -0.686756533592704 0.0440721975484417 MirTarget;mirMAP -0.314355834677681 0.00714535836435611 NA NA NA hsa-miR-16-5p GNB1 0.200674510503047 0.0593717079356147 -0.0763143135266766 0.38671343198555 miRNAWalker2_validate -0.127806494856928 0.00267217894310398 NA NA NA hsa-miR-30b-3p GNB3 -0.976858856774298 4.89616633369313e-08 1.73536007775473 1.52360671806275e-14 MirTarget -0.173932024221723 0.00845838817657574 NA NA NA hsa-miR-326 GNB3 -2.468565451901 1.23182221778132e-19 1.73536007775473 1.52360671806275e-14 miRanda -0.324789923282435 8.68661592033646e-16 NA NA NA hsa-miR-330-5p GNB3 0.168243129357275 0.239196436552122 1.73536007775473 1.52360671806275e-14 miRanda -0.22315722531978 0.00814399356479579 NA NA NA hsa-let-7f-1-3p GNB4 0.0152174523424196 0.909387255829372 -0.479705245819212 0.00875572294165981 MirTarget -0.139980382154704 0.0490196098983897 NA NA NA hsa-miR-103a-2-5p GNB4 1.89326161187553 3.13008877983253e-17 -0.479705245819212 0.00875572294165981 MirTarget -0.19967758811673 7.24931095288649e-07 NA NA NA hsa-miR-16-2-3p GNB4 0.505774348451832 0.00083906759991608 -0.479705245819212 0.00875572294165981 mirMAP -0.155653570657576 0.0119091800127774 NA NA NA hsa-miR-186-5p GNB4 0.439819047090102 6.33375570167175e-05 -0.479705245819212 0.00875572294165981 MirTarget -0.283343236423977 0.000897567990387685 NA NA NA hsa-miR-27b-3p GNB4 0.0774984459252845 0.455541249499373 -0.479705245819212 0.00875572294165981 miRNAWalker2_validate -0.255710837827021 0.00526497274642109 NA NA NA hsa-miR-33a-3p GNB4 0.540032749009224 0.00270907254062352 -0.479705245819212 0.00875572294165981 MirTarget -0.117436086641488 0.0257720234425025 NA NA NA hsa-miR-361-5p GNB4 -0.0236974652105824 0.799888526193556 -0.479705245819212 0.00875572294165981 miRanda;miRNATAP -0.478528141722597 2.30766803105107e-06 NA NA NA hsa-miR-429 GNB4 1.44127712764248 1.7824212712414e-11 -0.479705245819212 0.00875572294165981 miRanda -0.266942923813112 1.44582061028718e-10 NA NA NA hsa-miR-501-5p GNB4 0.316742767698094 0.0632047358679198 -0.479705245819212 0.00875572294165981 mirMAP -0.245058543657674 7.60906250881742e-06 NA NA NA hsa-miR-582-5p GNB4 -0.0134667168827214 0.939685711149187 -0.479705245819212 0.00875572294165981 MirTarget -0.193867260650251 0.000233739886242971 NA NA NA hsa-miR-590-3p GNB4 0.9225805269779 6.0121446263776e-11 -0.479705245819212 0.00875572294165981 MirTarget;miRanda -0.307140457661033 1.98326772229482e-06 NA NA NA hsa-miR-616-5p GNB4 2.3596511369846 3.26881700557061e-22 -0.479705245819212 0.00875572294165981 MirTarget -0.1092177386897 0.00355424830631546 NA NA NA hsa-miR-7-1-3p GNB4 1.23074353429962 9.62692371802457e-18 -0.479705245819212 0.00875572294165981 MirTarget -0.224310903099567 0.00033327080226094 NA NA NA hsa-miR-877-5p GNB4 2.90093737151303 2.52134268016683e-35 -0.479705245819212 0.00875572294165981 MirTarget -0.195934461202091 8.74170617235857e-08 NA NA NA hsa-miR-93-5p GNB4 1.27151657903037 1.96654008726155e-14 -0.479705245819212 0.00875572294165981 miRNAWalker2_validate -0.232797832245265 1.74237217112885e-05 NA NA NA hsa-miR-96-5p GNB4 2.81159638603625 3.72452637775194e-34 -0.479705245819212 0.00875572294165981 MirTarget -0.215378246540265 3.20942673334239e-09 NA NA NA hsa-miR-338-3p GNB5 -2.39495045399875 3.50911311863594e-28 0.553883959752518 2.3600063028472e-07 miRanda -0.104094144824586 9.14287166335618e-06 NA NA NA hsa-miR-342-3p GNB5 0.34628335679908 0.0121498405984511 0.553883959752518 2.3600063028472e-07 miRanda -0.100357030381319 0.0129259622168617 NA NA NA hsa-miR-320b GNG11 1.16387990475466 1.33051259463572e-10 -3.39284763926963 1.96911672174661e-68 miRanda -0.369697212676088 5.32317302852421e-09 NA NA NA hsa-miR-107 GNG12 -0.456345046928702 5.29231946717953e-06 -0.292954942460235 0.0259717352350613 miRanda -0.202577398515895 0.00257629515411815 NA NA NA hsa-miR-28-5p GNG12 0.189534080376749 0.0278108067630943 -0.292954942460235 0.0259717352350613 PITA;miRanda -0.201655225871001 0.0113988468458268 NA NA NA hsa-miR-374a-5p GNG12 -0.371522195407694 3.64288279697975e-05 -0.292954942460235 0.0259717352350613 mirMAP -0.351608971369976 2.54736777454557e-06 NA NA NA hsa-miR-374b-5p GNG12 -0.490675710652087 1.35508117735881e-06 -0.292954942460235 0.0259717352350613 mirMAP -0.330181493871441 4.58718963806129e-07 NA NA NA hsa-miR-423-5p GNG12 0.427072818804231 0.0012124903743904 -0.292954942460235 0.0259717352350613 miRNAWalker2_validate -0.239090672695268 2.24964591426155e-06 NA NA NA hsa-miR-590-3p GNG12 0.9225805269779 6.0121446263776e-11 -0.292954942460235 0.0259717352350613 miRanda;mirMAP -0.149035715229836 0.0014170715842639 NA NA NA hsa-miR-590-5p GNG12 1.22823897140696 7.5538778278798e-17 -0.292954942460235 0.0259717352350613 PITA -0.140426409367502 0.00135913185020513 NA NA NA hsa-miR-96-5p GNG12 2.81159638603625 3.72452637775194e-34 -0.292954942460235 0.0259717352350613 TargetScan -0.16376524236062 3.05609713711331e-10 NA NA NA hsa-miR-129-5p GNG2 2.0409652261565 1.19491474689015e-07 -1.98467659831585 4.25894834654724e-24 mirMAP -0.146671249704403 4.64390042720151e-08 NA NA NA hsa-miR-21-5p GNG2 1.07034578283768 3.39448630342548e-28 -1.98467659831585 4.25894834654724e-24 miRNATAP -0.329799847518816 0.00138205909690815 NA NA NA hsa-miR-28-5p GNG2 0.189534080376749 0.0278108067630943 -1.98467659831585 4.25894834654724e-24 miRanda;miRNATAP -0.482866485420342 0.000125852884122174 NA NA NA hsa-miR-3065-5p GNG2 -0.963317497666877 0.000100334146005009 -1.98467659831585 4.25894834654724e-24 mirMAP;miRNATAP -0.125372868636258 0.00363866126150709 NA NA NA hsa-miR-324-5p GNG2 1.21634042749489 1.07503319022833e-13 -1.98467659831585 4.25894834654724e-24 miRanda -0.54734915632893 1.08136296484733e-19 NA NA NA hsa-miR-335-3p GNG2 0.462639143507351 0.00828753288457869 -1.98467659831585 4.25894834654724e-24 mirMAP -0.392812269838174 4.13784835904294e-11 NA NA NA hsa-miR-429 GNG2 1.44127712764248 1.7824212712414e-11 -1.98467659831585 4.25894834654724e-24 miRanda;miRNATAP -0.418399773200611 1.37084588810866e-19 NA NA NA hsa-miR-500a-5p GNG2 0.202654345352218 0.2571507084955 -1.98467659831585 4.25894834654724e-24 mirMAP -0.267762071656297 6.61000651935826e-06 NA NA NA hsa-miR-576-5p GNG2 0.993748428316612 2.24066125794743e-10 -1.98467659831585 4.25894834654724e-24 mirMAP -0.401490554834819 8.82819209438605e-10 NA NA NA hsa-miR-577 GNG2 3.5197399300515 1.67960995324817e-16 -1.98467659831585 4.25894834654724e-24 PITA;miRNATAP -0.145264641130523 4.12074327990004e-08 NA NA NA hsa-miR-590-3p GNG2 0.9225805269779 6.0121446263776e-11 -1.98467659831585 4.25894834654724e-24 PITA;miRanda;mirMAP;miRNATAP -0.398346248305847 5.40612904247628e-08 NA NA NA hsa-miR-590-5p GNG2 1.22823897140696 7.5538778278798e-17 -1.98467659831585 4.25894834654724e-24 miRanda;miRNATAP -0.564460087050284 3.415876640414e-17 NA NA NA hsa-miR-944 GNG2 6.31318502943581 6.64615435406088e-56 -1.98467659831585 4.25894834654724e-24 mirMAP -0.276154103138574 2.4520143039971e-41 NA NA NA hsa-miR-126-5p GNG4 -1.94634635849451 2.4038399235921e-37 4.38348901012144 9.17328394702805e-29 mirMAP -0.875923186536989 3.81089529061369e-12 NA NA NA hsa-miR-142-5p GNG4 -0.0363288420100352 0.821716201807163 4.38348901012144 9.17328394702805e-29 mirMAP -0.409512324914838 0.00253675699080035 NA NA NA hsa-miR-223-5p GNG4 -1.01256221926103 1.1031676345056e-05 4.38348901012144 9.17328394702805e-29 mirMAP -0.461241342736772 7.06579118141508e-07 NA NA NA hsa-miR-23a-3p GNG4 -0.0903829051318041 0.377264294498572 4.38348901012144 9.17328394702805e-29 mirMAP -0.566318721646155 0.00878805347354433 NA NA NA hsa-miR-326 GNG4 -2.468565451901 1.23182221778132e-19 4.38348901012144 9.17328394702805e-29 mirMAP -0.357876461597806 2.11403311105827e-06 NA NA NA hsa-miR-338-3p GNG4 -2.39495045399875 3.50911311863594e-28 4.38348901012144 9.17328394702805e-29 miRanda -0.644588060582591 8.99023554872845e-13 NA NA NA hsa-miR-1271-5p GNG7 1.0987045785026 1.5617128114028e-09 -2.41098842784727 1.82778121868548e-27 mirMAP -0.286872042303439 1.12765919495684e-05 NA NA NA hsa-miR-129-5p GNG7 2.0409652261565 1.19491474689015e-07 -2.41098842784727 1.82778121868548e-27 mirMAP -0.147001811062736 1.89240569962486e-06 NA NA NA hsa-miR-141-3p GNG7 1.96958415696982 1.4648441542521e-24 -2.41098842784727 1.82778121868548e-27 MirTarget;TargetScan;miRNATAP -0.615621751911214 7.49888403339795e-29 NA NA NA hsa-miR-17-3p GNG7 -0.0552375132842826 0.669668193529718 -2.41098842784727 1.82778121868548e-27 mirMAP -0.257074484139053 0.00697500207015845 NA NA NA hsa-miR-182-5p GNG7 2.16789823981744 5.64205069446407e-26 -2.41098842784727 1.82778121868548e-27 mirMAP -0.523197488202188 1.33470842989975e-23 NA NA NA hsa-miR-185-3p GNG7 -0.00708838970417514 0.966551345765524 -2.41098842784727 1.82778121868548e-27 mirMAP -0.215621909814449 0.00297329935235291 NA NA NA hsa-miR-18a-3p GNG7 2.05585109851169 1.40576069637563e-20 -2.41098842784727 1.82778121868548e-27 mirMAP -0.41104159527509 5.29811122425285e-16 NA NA NA hsa-miR-18a-5p GNG7 0.941249745535531 1.37246345065862e-06 -2.41098842784727 1.82778121868548e-27 mirMAP -0.423137966128953 2.22679704772982e-12 NA NA NA hsa-miR-193b-5p GNG7 2.23194516649453 9.37859922398903e-29 -2.41098842784727 1.82778121868548e-27 mirMAP -0.413075477870501 4.39326254899698e-14 NA NA NA hsa-miR-200a-3p GNG7 1.41385743755862 3.01641811769439e-11 -2.41098842784727 1.82778121868548e-27 MirTarget;miRNATAP -0.383338378784082 1.89418064552046e-12 NA NA NA hsa-miR-22-5p GNG7 0.572104677310157 8.96288502279847e-06 -2.41098842784727 1.82778121868548e-27 mirMAP -0.216157855697048 0.022413551418189 NA NA NA hsa-miR-224-5p GNG7 2.66023106212545 6.37784852724057e-19 -2.41098842784727 1.82778121868548e-27 mirMAP -0.362994377912706 3.46828897718138e-23 NA NA NA hsa-miR-31-5p GNG7 4.55834486468821 4.36738083192596e-25 -2.41098842784727 1.82778121868548e-27 mirMAP -0.176148666480784 3.55272962556174e-11 NA NA NA hsa-miR-3127-5p GNG7 1.29473183527726 5.09730792828934e-15 -2.41098842784727 1.82778121868548e-27 mirMAP -0.438482035760149 3.45106952866245e-10 NA NA NA hsa-miR-3615 GNG7 0.574849974972113 0.000529063374731681 -2.41098842784727 1.82778121868548e-27 mirMAP -0.245174169333891 0.000822405366178944 NA NA NA hsa-miR-378a-3p GNG7 0.590540647783337 0.000399996797136959 -2.41098842784727 1.82778121868548e-27 mirMAP -0.437539687257013 9.96656976327186e-10 NA NA NA hsa-miR-532-3p GNG7 0.62928908928122 1.1124581803679e-05 -2.41098842784727 1.82778121868548e-27 mirMAP -0.179640053117825 0.0346715794530451 NA NA NA hsa-miR-590-3p GNG7 0.9225805269779 6.0121446263776e-11 -2.41098842784727 1.82778121868548e-27 PITA;miRanda;mirMAP -0.398949216255457 2.16221671391666e-06 NA NA NA hsa-miR-616-5p GNG7 2.3596511369846 3.26881700557061e-22 -2.41098842784727 1.82778121868548e-27 MirTarget -0.320221088757825 1.86946777112696e-11 NA NA NA hsa-miR-671-5p GNG7 2.24826787094975 1.21091062273857e-36 -2.41098842784727 1.82778121868548e-27 mirMAP -0.595491863509738 2.93836770555148e-24 NA NA NA hsa-miR-9-5p GNG7 4.97757576742384 8.49748323724349e-41 -2.41098842784727 1.82778121868548e-27 mirMAP -0.267338257109037 5.99562235812521e-22 NA NA NA hsa-miR-92a-3p GNG7 0.779792182638042 4.45572871602003e-09 -2.41098842784727 1.82778121868548e-27 miRNAWalker2_validate -0.67180863608471 1.84444508778508e-14 NA NA NA hsa-miR-939-5p GNG7 1.36997300674111 9.97643104288974e-13 -2.41098842784727 1.82778121868548e-27 mirMAP -0.341745849668095 1.2549788732269e-07 NA NA NA hsa-miR-940 GNG7 1.91696621517233 1.3556247816872e-17 -2.41098842784727 1.82778121868548e-27 MirTarget -0.319889942743042 3.86430516062054e-10 NA NA NA hsa-miR-96-5p GNG7 2.81159638603625 3.72452637775194e-34 -2.41098842784727 1.82778121868548e-27 mirMAP -0.50452282442985 1.55430931154604e-29 NA NA NA hsa-miR-126-5p GNGT1 -1.94634635849451 2.4038399235921e-37 4.97522745805058 2.28567337814306e-57 mirMAP -1.01884092209144 2.55334104813364e-22 NA NA NA hsa-miR-146b-5p GNGT1 -0.432155779449763 0.00591587599739451 4.97522745805058 2.28567337814306e-57 miRanda -0.469842211210412 7.03141772018637e-05 NA NA NA hsa-miR-219a-1-3p GNGT2 1.29353619852611 8.17241140944721e-12 -2.03483312326513 7.92149359135085e-25 MirTarget -0.502674368486024 1.70049639971819e-21 NA NA NA hsa-miR-542-3p GNGT2 0.0944680117124008 0.47453779285373 -2.03483312326513 7.92149359135085e-25 miRanda -0.268219921910904 0.00111847112238815 NA NA NA hsa-miR-101-3p GSK3B -2.01992291103908 2.62945171087274e-42 0.499712487818105 9.61183073682402e-08 miRNATAP -0.105379312755965 0.000303724875610772 NA NA NA hsa-miR-126-5p GSK3B -1.94634635849451 2.4038399235921e-37 0.499712487818105 9.61183073682402e-08 mirMAP;miRNATAP -0.155118937533877 4.90775253770866e-08 NA NA NA hsa-miR-139-5p GSK3B -2.25560964518719 9.95317711940085e-30 0.499712487818105 9.61183073682402e-08 mirMAP -0.125561016122415 1.4140259689311e-08 NA NA NA hsa-miR-142-5p GSK3B -0.0363288420100352 0.821716201807163 0.499712487818105 9.61183073682402e-08 mirMAP;miRNATAP -0.171159931551704 8.69354955549066e-09 NA NA NA hsa-miR-146b-3p GSK3B -1.37101198101784 3.08716512915079e-22 0.499712487818105 9.61183073682402e-08 miRNATAP -0.219745127774368 3.92179905335662e-12 NA NA NA hsa-miR-146b-5p GSK3B -0.432155779449763 0.00591587599739451 0.499712487818105 9.61183073682402e-08 miRanda -0.178269196067507 4.3865438579379e-09 NA NA NA hsa-miR-150-5p GSK3B -0.862350644813022 0.000126661451795198 0.499712487818105 9.61183073682402e-08 miRNATAP -0.111716944828564 1.20516721980085e-07 NA NA NA hsa-miR-155-5p GSK3B 0.459859353454849 0.00515473360914761 0.499712487818105 9.61183073682402e-08 miRNAWalker2_validate;miRNATAP -0.145500116799098 6.08907796032861e-07 NA NA NA hsa-miR-181a-5p GSK3B -1.31879909071317 2.04570351303734e-24 0.499712487818105 9.61183073682402e-08 mirMAP -0.14367181696082 4.39408951961526e-05 NA NA NA hsa-miR-26a-5p GSK3B -0.929312251092796 7.48452512025337e-23 0.499712487818105 9.61183073682402e-08 miRNAWalker2_validate;miRNATAP -0.285030474483841 3.40305913240992e-09 NA NA NA hsa-miR-29a-3p GSK3B -1.03082784302378 5.4721714495133e-16 0.499712487818105 9.61183073682402e-08 miRNATAP -0.248363970372269 4.59157485058825e-12 NA NA NA hsa-miR-29b-3p GSK3B -0.0219237619606503 0.883966228726957 0.499712487818105 9.61183073682402e-08 miRTarBase;miRNATAP -0.157160685685258 1.01681209580903e-06 NA NA NA hsa-miR-29c-3p GSK3B -1.50225173284958 1.90087771871443e-16 0.499712487818105 9.61183073682402e-08 miRNATAP -0.121111901595348 1.6343187987793e-06 NA NA NA hsa-miR-340-5p GSK3B 0.172446891226333 0.176440862972852 0.499712487818105 9.61183073682402e-08 mirMAP -0.122880752230023 0.00132484493197563 NA NA NA hsa-miR-342-3p GSK3B 0.34628335679908 0.0121498405984511 0.499712487818105 9.61183073682402e-08 miRanda -0.128561960161591 0.000252023883111578 NA NA NA hsa-miR-374a-5p GSK3B -0.371522195407694 3.64288279697975e-05 0.499712487818105 9.61183073682402e-08 mirMAP -0.186780160215569 0.000579550235025245 NA NA NA hsa-miR-374b-5p GSK3B -0.490675710652087 1.35508117735881e-06 0.499712487818105 9.61183073682402e-08 mirMAP -0.126368319178402 0.00820982070848097 NA NA NA hsa-let-7b-5p GYS1 -0.759197439090238 1.31014217546415e-10 1.05279799387274 2.34597429444759e-21 miRNAWalker2_validate -0.124018084840611 0.012974521260635 NA NA NA hsa-miR-140-5p GYS1 -0.615965395622439 1.05820583250804e-08 1.05279799387274 2.34597429444759e-21 MirTarget;PITA;miRanda;miRNATAP -0.2445138913693 7.91328531100096e-06 NA NA NA hsa-miR-29b-2-5p GYS1 -1.04734214410093 8.2886590108117e-14 1.05279799387274 2.34597429444759e-21 MirTarget -0.193367643369683 2.48146123261374e-06 NA NA NA hsa-let-7a-3p HGF 0.0442588630386531 0.71354010406076 -3.20280139675575 2.6335259230455e-25 mirMAP -0.331440381352565 0.019247593199204 NA NA NA hsa-miR-129-5p HGF 2.0409652261565 1.19491474689015e-07 -3.20280139675575 2.6335259230455e-25 mirMAP -0.189366270641891 8.99826866184366e-06 NA NA NA hsa-miR-141-3p HGF 1.96958415696982 1.4648441542521e-24 -3.20280139675575 2.6335259230455e-25 MirTarget;TargetScan -0.928937856912761 2.03833847534243e-35 NA NA NA hsa-miR-200a-3p HGF 1.41385743755862 3.01641811769439e-11 -3.20280139675575 2.6335259230455e-25 MirTarget -0.652955279683911 8.21242723565594e-19 NA NA NA hsa-miR-203a-3p HGF 1.5633612920102 3.65621097298307e-07 -3.20280139675575 2.6335259230455e-25 MirTarget -0.432787384975738 6.67536692392743e-17 NA NA NA hsa-miR-224-3p HGF 0.735089473712282 0.00175854245266733 -3.20280139675575 2.6335259230455e-25 mirMAP -0.309473481751138 1.60212453067725e-05 NA NA NA hsa-miR-26b-5p HGF -0.0183893267106221 0.882303333465809 -3.20280139675575 2.6335259230455e-25 MirTarget;miRNATAP -0.280208989529121 0.0415139267449846 NA NA NA hsa-miR-335-3p HGF 0.462639143507351 0.00828753288457869 -3.20280139675575 2.6335259230455e-25 mirMAP -0.254786861686945 0.00810807836010113 NA NA NA hsa-miR-33a-3p HGF 0.540032749009224 0.00270907254062352 -3.20280139675575 2.6335259230455e-25 mirMAP -0.446438844474155 1.85788966741103e-06 NA NA NA hsa-miR-3682-3p HGF 1.00929490472499 5.45439049842858e-08 -3.20280139675575 2.6335259230455e-25 mirMAP -0.42568599455483 4.93964801604821e-06 NA NA NA hsa-miR-421 HGF 1.16807936195133 1.4164941985739e-11 -3.20280139675575 2.6335259230455e-25 miRanda -0.54132850072237 8.56309315013643e-09 NA NA NA hsa-miR-429 HGF 1.44127712764248 1.7824212712414e-11 -3.20280139675575 2.6335259230455e-25 miRanda -0.626317695844433 1.37787037549644e-17 NA NA NA hsa-miR-590-3p HGF 0.9225805269779 6.0121446263776e-11 -3.20280139675575 2.6335259230455e-25 miRanda;mirMAP -0.70885581177089 7.10843015751565e-10 NA NA NA hsa-miR-590-5p HGF 1.22823897140696 7.5538778278798e-17 -3.20280139675575 2.6335259230455e-25 miRanda -0.895885278053414 2.20529348289796e-17 NA NA NA hsa-miR-616-5p HGF 2.3596511369846 3.26881700557061e-22 -3.20280139675575 2.6335259230455e-25 mirMAP -0.505267380674254 8.77950261008762e-15 NA NA NA hsa-miR-651-5p HGF 1.13786424698224 4.46093918185845e-07 -3.20280139675575 2.6335259230455e-25 MirTarget -0.3246304033797 9.31038030130863e-06 NA NA NA hsa-miR-7-1-3p HGF 1.23074353429962 9.62692371802457e-18 -3.20280139675575 2.6335259230455e-25 mirMAP -0.736690661943521 2.23106843328226e-11 NA NA NA hsa-miR-944 HGF 6.31318502943581 6.64615435406088e-56 -3.20280139675575 2.6335259230455e-25 mirMAP -0.384572402806975 9.10698679263152e-31 NA NA NA hsa-let-7a-5p HRAS -0.644221394537031 9.97672106245846e-14 1.31862679594751 3.48799847787448e-24 miRNAWalker2_validate;miRTarBase -0.392335402535148 8.54845954821473e-07 18344688;20033209;20607356;23134218;19323605 Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression lung cancer;lung cancer;glioblastoma;lung squamous cell cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.759197439090238 1.31014217546415e-10 1.31862679594751 3.48799847787448e-24 miRTarBase -0.183430879625724 0.00183412460137215 18344688;20033209;20607356;20881268;19323605 Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;drug resistance;progression lung cancer;lung cancer;glioblastoma;colorectal cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.50460346732144 5.17074613336112e-23 1.31862679594751 3.48799847787448e-24 miRNAWalker2_validate;miRTarBase -0.233731686653197 6.5763932300231e-08 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-181a-5p HRAS -1.31879909071317 2.04570351303734e-24 1.31862679594751 3.48799847787448e-24 miRNAWalker2_validate;miRTarBase -0.414716184156695 5.82006120340242e-17 NA NA NA hsa-miR-181d-5p HRAS -0.225424526304381 0.151955641871942 1.31862679594751 3.48799847787448e-24 miRNAWalker2_validate;miRTarBase -0.204155803844354 5.30673999612873e-06 NA NA NA hsa-let-7b-5p HSP90AA1 -0.759197439090238 1.31014217546415e-10 0.539193763219579 2.08628525642442e-07 miRNAWalker2_validate -0.110584307658599 0.0136547715229723 NA NA NA hsa-miR-10a-5p HSP90AA1 -0.646485219146053 7.58185610123523e-08 0.539193763219579 2.08628525642442e-07 miRNAWalker2_validate -0.162047745685506 0.000245024798126896 NA NA NA hsa-miR-30c-5p HSP90AA1 -0.426804145561029 0.00403132854321475 0.539193763219579 2.08628525642442e-07 miRNAWalker2_validate -0.181999609368073 3.81143941561566e-07 NA NA NA hsa-miR-30e-5p HSP90AA1 0.186424244301373 0.077486249643257 0.539193763219579 2.08628525642442e-07 miRNAWalker2_validate -0.160785386076036 0.00179751605852803 NA NA NA hsa-miR-1-3p HSP90B1 -2.66147018870582 3.25607598393088e-22 0.908237527501271 5.76944930727143e-22 MirTarget -0.139400040797395 1.74265018163585e-16 NA NA NA hsa-miR-150-5p HSP90B1 -0.862350644813022 0.000126661451795198 0.908237527501271 5.76944930727143e-22 MirTarget -0.137175947133434 4.41888931093251e-10 NA NA NA hsa-miR-15a-5p HSP90B1 -0.24629041301676 0.0253630661893983 0.908237527501271 5.76944930727143e-22 miRNAWalker2_validate -0.119448932292782 0.0105385447060538 NA NA NA hsa-miR-16-5p HSP90B1 0.200674510503047 0.0593717079356147 0.908237527501271 5.76944930727143e-22 miRNAWalker2_validate -0.111791508733149 0.0211015970405433 NA NA NA hsa-miR-181a-5p HSP90B1 -1.31879909071317 2.04570351303734e-24 0.908237527501271 5.76944930727143e-22 MirTarget -0.172906985794208 2.55928548104582e-06 NA NA NA hsa-miR-181c-5p HSP90B1 -1.36921360773694 5.61046203952059e-19 0.908237527501271 5.76944930727143e-22 MirTarget -0.15751515826294 4.5927013736452e-07 NA NA NA hsa-miR-139-5p IBSP -2.25560964518719 9.95317711940085e-30 4.03175536486539 9.82832170445471e-32 miRanda -0.687098432310136 1.08116038768363e-15 NA NA NA hsa-miR-26b-5p IBSP -0.0183893267106221 0.882303333465809 4.03175536486539 9.82832170445471e-32 miRNAWalker2_validate -0.346496133856662 0.0265497257427932 NA NA NA hsa-miR-141-3p IFNAR1 1.96958415696982 1.4648441542521e-24 -0.659546352301676 5.97567648367518e-16 TargetScan -0.178690877079556 5.47802047682258e-19 NA NA NA hsa-miR-186-5p IFNAR1 0.439819047090102 6.33375570167175e-05 -0.659546352301676 5.97567648367518e-16 mirMAP -0.141524447968169 0.000309744373359609 NA NA NA hsa-miR-200c-3p IFNAR1 1.44830286955223 1.39903737828795e-22 -0.659546352301676 5.97567648367518e-16 mirMAP -0.198499645512804 1.12499457764142e-13 NA NA NA hsa-miR-33a-3p IFNAR1 0.540032749009224 0.00270907254062352 -0.659546352301676 5.97567648367518e-16 mirMAP -0.107737630928502 7.22416189990461e-06 NA NA NA hsa-miR-361-5p IFNAR1 -0.0236974652105824 0.799888526193556 -0.659546352301676 5.97567648367518e-16 miRanda -0.111805145554048 0.0177360174278053 NA NA NA hsa-miR-616-5p IFNAR1 2.3596511369846 3.26881700557061e-22 -0.659546352301676 5.97567648367518e-16 mirMAP -0.119479794155182 1.08039415947564e-12 NA NA NA hsa-miR-106b-5p IFNAR2 0.768146314773296 1.22330832259683e-08 -0.745432198177307 1.31074907206119e-11 miRNAWalker2_validate -0.369313647026375 4.2620162293666e-20 NA NA NA hsa-miR-1271-5p IFNAR2 1.0987045785026 1.5617128114028e-09 -0.745432198177307 1.31074907206119e-11 mirMAP -0.187205788030925 8.40016161983241e-10 NA NA NA hsa-miR-141-3p IFNAR2 1.96958415696982 1.4648441542521e-24 -0.745432198177307 1.31074907206119e-11 mirMAP -0.262141687947413 5.30124115082126e-23 NA NA NA hsa-miR-200a-3p IFNAR2 1.41385743755862 3.01641811769439e-11 -0.745432198177307 1.31074907206119e-11 mirMAP -0.168352200204138 7.30904984357322e-11 NA NA NA hsa-miR-339-5p IFNAR2 0.695129802377533 1.42149990793285e-05 -0.745432198177307 1.31074907206119e-11 miRanda -0.255403584554107 1.967805783824e-13 NA NA NA hsa-miR-484 IFNAR2 0.290563207815661 0.0187067524486015 -0.745432198177307 1.31074907206119e-11 miRNAWalker2_validate -0.139419396447976 0.00302294873890792 NA NA NA hsa-let-7a-3p IGF1 0.0442588630386531 0.71354010406076 -1.37799457072063 5.6005664546468e-06 mirMAP -0.719218912366477 2.92507494354725e-08 NA NA NA hsa-let-7f-1-3p IGF1 0.0152174523424196 0.909387255829372 -1.37799457072063 5.6005664546468e-06 mirMAP -0.39674239000585 0.000815770296327635 NA NA NA hsa-miR-103a-2-5p IGF1 1.89326161187553 3.13008877983253e-17 -1.37799457072063 5.6005664546468e-06 mirMAP -0.439184380584376 4.47890605831597e-11 NA NA NA hsa-miR-129-5p IGF1 2.0409652261565 1.19491474689015e-07 -1.37799457072063 5.6005664546468e-06 MirTarget;PITA;miRanda -0.10321192560123 0.00998249153187407 NA NA NA hsa-miR-130a-3p IGF1 -0.124312418026753 0.382773698737926 -1.37799457072063 5.6005664546468e-06 MirTarget -0.415188875983358 0.000172436137931997 NA NA NA hsa-miR-130b-3p IGF1 2.60393336883065 1.5273795648739e-42 -1.37799457072063 5.6005664546468e-06 MirTarget -0.513176204779105 6.68000839449803e-13 NA NA NA hsa-miR-15b-3p IGF1 0.720785796663996 5.61234325663636e-07 -1.37799457072063 5.6005664546468e-06 mirMAP -0.643322609629894 1.26123722750811e-09 NA NA NA hsa-miR-16-1-3p IGF1 -0.156899711138322 0.214597270113743 -1.37799457072063 5.6005664546468e-06 mirMAP -0.304660951027777 0.0151521595531882 NA NA NA hsa-miR-186-5p IGF1 0.439819047090102 6.33375570167175e-05 -1.37799457072063 5.6005664546468e-06 mirMAP -0.295276895259746 0.0396759027709803 NA NA NA hsa-miR-19a-3p IGF1 1.29022522620563 7.13786738838458e-11 -1.37799457072063 5.6005664546468e-06 MirTarget -0.460504890057067 1.31201324421002e-09 NA NA NA hsa-miR-19b-1-5p IGF1 0.550369246540305 0.000830309981399621 -1.37799457072063 5.6005664546468e-06 mirMAP -0.521437551403417 2.61809634124468e-08 NA NA NA hsa-miR-19b-3p IGF1 0.786722036548617 1.29623163115342e-06 -1.37799457072063 5.6005664546468e-06 MirTarget -0.589435016098139 3.08838568154898e-10 NA NA NA hsa-miR-20a-3p IGF1 1.79890197957803 9.4283425564752e-24 -1.37799457072063 5.6005664546468e-06 mirMAP -0.609651283474211 2.20262275289989e-14 NA NA NA hsa-miR-26b-5p IGF1 -0.0183893267106221 0.882303333465809 -1.37799457072063 5.6005664546468e-06 mirMAP -0.302778973756389 0.0179074173658107 NA NA NA hsa-miR-27a-3p IGF1 0.140284703630369 0.213001086994521 -1.37799457072063 5.6005664546468e-06 miRNAWalker2_validate;miRTarBase -0.910340521189987 3.89445747957779e-11 NA NA NA hsa-miR-28-3p IGF1 0.489939093276698 1.09817766591435e-06 -1.37799457072063 5.6005664546468e-06 MirTarget -0.58657074523771 0.00016358174972328 NA NA NA hsa-miR-301a-3p IGF1 1.23940945645189 2.05328421457283e-11 -1.37799457072063 5.6005664546468e-06 MirTarget -0.485097118273805 2.36771418933099e-09 NA NA NA hsa-miR-301b-3p IGF1 2.73590939539747 6.81394899610837e-22 -1.37799457072063 5.6005664546468e-06 MirTarget -0.34845344169365 3.50649082599005e-09 NA NA NA hsa-miR-3065-5p IGF1 -0.963317497666877 0.000100334146005009 -1.37799457072063 5.6005664546468e-06 mirMAP -0.19636533196353 0.00192929426255964 NA NA NA hsa-miR-320a IGF1 0.25030125889857 0.0695425511666725 -1.37799457072063 5.6005664546468e-06 miRNATAP -0.505752312845182 8.50310254891912e-06 NA NA NA hsa-miR-320b IGF1 1.16387990475466 1.33051259463572e-10 -1.37799457072063 5.6005664546468e-06 miRNATAP -0.434596464203867 2.01696137897456e-07 NA NA NA hsa-miR-33a-3p IGF1 0.540032749009224 0.00270907254062352 -1.37799457072063 5.6005664546468e-06 MirTarget -0.439825382386986 4.32674150821452e-07 NA NA NA hsa-miR-361-5p IGF1 -0.0236974652105824 0.799888526193556 -1.37799457072063 5.6005664546468e-06 PITA;mirMAP -0.356097088913026 0.0380378431371018 NA NA NA hsa-miR-362-5p IGF1 0.26329593259106 0.182949931130249 -1.37799457072063 5.6005664546468e-06 mirMAP -0.313157840343392 7.59806255898351e-05 NA NA NA hsa-miR-421 IGF1 1.16807936195133 1.4164941985739e-11 -1.37799457072063 5.6005664546468e-06 PITA -0.400511766536838 5.7162798974993e-06 NA NA NA hsa-miR-450b-5p IGF1 1.40607004112146 2.03869814951451e-15 -1.37799457072063 5.6005664546468e-06 MirTarget;PITA;mirMAP;miRNATAP -0.350122646863761 3.74159386323848e-05 NA NA NA hsa-miR-452-5p IGF1 1.08242667876786 2.34127628858457e-06 -1.37799457072063 5.6005664546468e-06 MirTarget;mirMAP -0.290062520578002 1.55466108530905e-05 NA NA NA hsa-miR-454-3p IGF1 0.942883363058312 9.73843658862518e-10 -1.37799457072063 5.6005664546468e-06 MirTarget -0.614704058536877 3.38197445544743e-10 NA NA NA hsa-miR-576-5p IGF1 0.993748428316612 2.24066125794743e-10 -1.37799457072063 5.6005664546468e-06 PITA;mirMAP;miRNATAP -0.520815287089503 7.49855498443781e-08 NA NA NA hsa-miR-590-3p IGF1 0.9225805269779 6.0121446263776e-11 -1.37799457072063 5.6005664546468e-06 MirTarget;miRanda;mirMAP;miRNATAP -0.594354890742706 3.33660533257597e-08 NA NA NA hsa-miR-629-5p IGF1 0.896078284709513 1.3248439450822e-08 -1.37799457072063 5.6005664546468e-06 mirMAP -0.27599806927933 0.00486926905966517 NA NA NA hsa-miR-940 IGF1 1.91696621517233 1.3556247816872e-17 -1.37799457072063 5.6005664546468e-06 MirTarget;PITA;miRNATAP -0.234914738266115 0.000438846247747855 NA NA NA hsa-let-7g-5p IGF1R 0.0868874053614963 0.322163222422263 0.982529332050234 4.62728018713948e-10 MirTarget;miRNATAP -0.245478044321601 0.0106352737119964 NA NA NA hsa-let-7i-5p IGF1R 0.140484500715033 0.0901764941286614 0.982529332050234 4.62728018713948e-10 MirTarget;miRNATAP -0.207276619716973 0.0422619328285073 NA NA NA hsa-miR-100-5p IGF1R -1.55858901419153 8.83648748818133e-17 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.187006318749739 8.02240625223969e-06 26306402 MiR 100 Inhibits Osteosarcoma Cell Proliferation Migration and Invasion and Enhances Chemosensitivity by Targeting IGFIR sarcoma hsa-miR-139-5p IGF1R -2.25560964518719 9.95317711940085e-30 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate;miRTarBase;MirTarget;PITA -0.217134613985734 7.74697433141007e-09 26097570 Furthermore we identified insulin-like growth factor 1 receptor IGF1R as a target of miR-139-5p and miR-139-5p function as a tumor suppressor via targeting IGF1R in NSCLC; Our results indicated that miR-139-5p acts as a tumor suppressor in NSCLC partially via down-regulating IGF1R expression lung squamous cell cancer hsa-miR-140-3p IGF1R -1.5688188604984 7.06409475976727e-33 0.982529332050234 4.62728018713948e-10 mirMAP -0.341867133561433 1.63654849432362e-09 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-140-5p IGF1R -0.615965395622439 1.05820583250804e-08 0.982529332050234 4.62728018713948e-10 PITA;miRNATAP -0.392259812365533 1.71034387290121e-07 24039995 Integrated analysis identified IGF1R as a direct and functional target of miR-140; Knockdown of IGF1R inhibited cell proliferation and invasion resembling that of miR-140 overexpression while overexpression of IGF1R attenuated the function of miR-140 in NSCLC cells; Together our results highlight the significance of miR-140 and IGF1R in the development and progression of NSCLC progression lung squamous cell cancer hsa-miR-145-3p IGF1R -1.41475926107847 2.20187227373045e-21 0.982529332050234 4.62728018713948e-10 mirMAP -0.126675769973236 0.0160219897254341 25474488 MiR 143 and MiR 145 regulate IGF1R to suppress cell proliferation in colorectal cancer; We identified specific target sites for miR-143 and miR-145 miR-143/145 in the 3'-untranslated region 3'-UTR of the IGF1R gene colorectal cancer hsa-miR-145-5p IGF1R -1.08109692150888 5.28948625689113e-14 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate;miRNATAP -0.131174950963583 0.0186799825584431 25474488 MiR 143 and MiR 145 regulate IGF1R to suppress cell proliferation in colorectal cancer; We identified specific target sites for miR-143 and miR-145 miR-143/145 in the 3'-untranslated region 3'-UTR of the IGF1R gene colorectal cancer hsa-miR-146b-5p IGF1R -0.432155779449763 0.00591587599739451 0.982529332050234 4.62728018713948e-10 miRanda -0.283110244071053 4.59559416992279e-08 NA NA NA hsa-miR-150-5p IGF1R -0.862350644813022 0.000126661451795198 0.982529332050234 4.62728018713948e-10 mirMAP -0.212618974241981 2.61405817985863e-09 NA NA NA hsa-miR-155-5p IGF1R 0.459859353454849 0.00515473360914761 0.982529332050234 4.62728018713948e-10 mirMAP -0.247262233492408 6.14770516840245e-07 NA NA NA hsa-miR-15a-5p IGF1R -0.24629041301676 0.0253630661893983 0.982529332050234 4.62728018713948e-10 miRNATAP -0.321263926105465 1.88217856104771e-05 NA NA NA hsa-miR-16-1-3p IGF1R -0.156899711138322 0.214597270113743 0.982529332050234 4.62728018713948e-10 mirMAP -0.159986849314756 0.0151494323232152 NA NA NA hsa-miR-16-5p IGF1R 0.200674510503047 0.0593717079356147 0.982529332050234 4.62728018713948e-10 miRNATAP -0.199131803259829 0.0111766097246827 23507142 Furthermore we confirmed that IGF1R is a direct target of miR-16; In clinical specimens IGF1R levels inversely correlate with miR-16 expression; Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS sarcoma hsa-miR-195-5p IGF1R -1.62452829530841 2.94084397454942e-29 0.982529332050234 4.62728018713948e-10 miRNATAP -0.255063898486277 1.10674891354809e-06 NA NA NA hsa-miR-223-3p IGF1R -1.24508255130122 3.45747878041931e-08 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.141281724319287 7.548833640901e-05 NA NA NA hsa-miR-29a-3p IGF1R -1.03082784302378 5.4721714495133e-16 0.982529332050234 4.62728018713948e-10 mirMAP -0.277242078341875 8.18754234050117e-06 NA NA NA hsa-miR-29b-2-5p IGF1R -1.04734214410093 8.2886590108117e-14 0.982529332050234 4.62728018713948e-10 mirMAP -0.312348889442624 2.78561794665151e-08 NA NA NA hsa-miR-29b-3p IGF1R -0.0219237619606503 0.883966228726957 0.982529332050234 4.62728018713948e-10 mirMAP -0.232999850470129 2.16922979060122e-05 NA NA NA hsa-miR-29c-3p IGF1R -1.50225173284958 1.90087771871443e-16 0.982529332050234 4.62728018713948e-10 mirMAP -0.192164433456799 7.98700810271213e-06 NA NA NA hsa-miR-30a-5p IGF1R -2.98793938555326 1.93840183838367e-49 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.148177644323036 2.90009612883459e-05 26025408 MiR 30a suppresses non small cell lung cancer progression through AKT signaling pathway by targeting IGF1R progression lung squamous cell cancer hsa-miR-30b-5p IGF1R -1.50117013761001 1.78247435398346e-20 0.982529332050234 4.62728018713948e-10 mirMAP -0.214074505550518 8.36120182810325e-06 NA NA NA hsa-miR-30c-5p IGF1R -0.426804145561029 0.00403132854321475 0.982529332050234 4.62728018713948e-10 mirMAP;miRNATAP -0.19669362552796 0.000388312599430804 NA NA NA hsa-miR-30d-5p IGF1R -2.06908130936031 2.23574479943606e-47 0.982529332050234 4.62728018713948e-10 mirMAP;miRNATAP -0.233901945943772 3.43855803813755e-06 NA NA NA hsa-miR-30e-5p IGF1R 0.186424244301373 0.077486249643257 0.982529332050234 4.62728018713948e-10 mirMAP -0.293195576840101 0.000197469842308509 NA NA NA hsa-miR-342-3p IGF1R 0.34628335679908 0.0121498405984511 0.982529332050234 4.62728018713948e-10 mirMAP -0.280297159346764 2.33869618325908e-06 NA NA NA hsa-miR-342-5p IGF1R 0.0539558901968578 0.673491296758105 0.982529332050234 4.62728018713948e-10 mirMAP -0.29545841818406 4.5254542871668e-06 NA NA NA hsa-miR-34a-5p IGF1R -0.43794334019748 0.000117590706048968 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate -0.294421780652786 4.62621883688401e-05 NA NA NA hsa-miR-362-3p IGF1R -0.604045380242671 0.000132629619624125 0.982529332050234 4.62728018713948e-10 PITA -0.137605501415943 0.00839654812994784 NA NA NA hsa-miR-374a-5p IGF1R -0.371522195407694 3.64288279697975e-05 0.982529332050234 4.62728018713948e-10 mirMAP -0.225267618553838 0.0150293514042127 NA NA NA hsa-miR-375 IGF1R -2.57769028725587 1.42344309409034e-12 0.982529332050234 4.62728018713948e-10 miRNATAP -0.100892074321695 3.4069456185114e-06 27129171;24571711;21813472 Together these results show that AE modulates cancer cells and the tumor microenvironment via activation of miR-375 and by targeting IGF1R and SNAIL1 in OC cells;Epigenetic silencing of miR 375 induces trastuzumab resistance in HER2 positive breast cancer by targeting IGF1R; miR-375 which was downregulated and predicted to target IGF1R in trastuzumab-resistant HER2-positive breast cancer cells could indeed inhibit the cellular luciferase activity in a reporter construct containing the 3'-UTR of IGF1R; A reverse correlation between the levels of miR-375 and IGF1R was validated in clinical breast cancers; Epigenetic silencing of miR-375 causes the upregulation of IGF1R which at least partially underlies trastuzumab resistance of breast cancer cells;Real-time quantitative PCR was applied to detectthe expression of miR-375 in ESCC samples and its correlation with insulin-like growth factor 1 receptor IGF1R; Further study showed that miR-375 could interact with the 3'-untranslated region of IGF1R and downregulate its expression; In clinical specimens the expression of IGF1R was also negatively correlated with miR-375 expression p=0.008; This study demonstrates that miR-375 has a strong tumour-suppressive effect through inhibiting the expression of IGF1R ;drug resistance; ovarian cancer;breast cancer;esophageal cancer hsa-miR-484 IGF1R 0.290563207815661 0.0187067524486015 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate -0.192145777387423 0.00421598851193384 NA NA NA hsa-miR-497-5p IGF1R -1.37093122385312 2.06413037457593e-23 0.982529332050234 4.62728018713948e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.160724961526762 0.00455038232480153 NA NA NA hsa-miR-500a-3p IGF1R 0.0997410457813883 0.420760746886716 0.982529332050234 4.62728018713948e-10 mirMAP -0.232636866319139 0.000518474755653464 NA NA NA hsa-miR-532-5p IGF1R -0.485749465832866 0.000138169498131266 0.982529332050234 4.62728018713948e-10 miRNATAP -0.15645209588549 0.0157194009855792 NA NA NA hsa-miR-141-3p IGF2 1.96958415696982 1.4648441542521e-24 -0.689838872603404 0.0793719101222569 MirTarget;TargetScan -0.428729398950731 1.03803932061265e-05 NA NA NA hsa-miR-193b-5p IGF2 2.23194516649453 9.37859922398903e-29 -0.689838872603404 0.0793719101222569 mirMAP -0.218594400313606 0.0189460889917031 NA NA NA hsa-miR-19a-3p IGF2 1.29022522620563 7.13786738838458e-11 -0.689838872603404 0.0793719101222569 mirMAP -0.29717428565897 0.00269891806844401 NA NA NA hsa-miR-19b-3p IGF2 0.786722036548617 1.29623163115342e-06 -0.689838872603404 0.0793719101222569 mirMAP -0.380825278404665 0.00185570154179484 NA NA NA hsa-miR-210-3p IGF2 4.69000861651894 7.31350086152822e-67 -0.689838872603404 0.0793719101222569 MirTarget -0.19261569019699 0.00178921899174357 NA NA NA hsa-miR-224-3p IGF2 0.735089473712282 0.00175854245266733 -0.689838872603404 0.0793719101222569 mirMAP -0.291170584834158 0.000708747648991385 NA NA NA hsa-miR-23a-5p IGF2 0.700108859043245 0.000788132353392114 -0.689838872603404 0.0793719101222569 MirTarget -0.341029721505097 0.000371801405777323 NA NA NA hsa-miR-301a-3p IGF2 1.23940945645189 2.05328421457283e-11 -0.689838872603404 0.0793719101222569 mirMAP -0.367444778560609 0.000509689551125869 NA NA NA hsa-miR-339-5p IGF2 0.695129802377533 1.42149990793285e-05 -0.689838872603404 0.0793719101222569 mirMAP -0.408659382394333 0.00102830100648851 NA NA NA hsa-miR-34a-5p IGF2 -0.43794334019748 0.000117590706048968 -0.689838872603404 0.0793719101222569 mirMAP -0.563164101257669 0.00147233034529543 NA NA NA hsa-miR-454-3p IGF2 0.942883363058312 9.73843658862518e-10 -0.689838872603404 0.0793719101222569 mirMAP -0.549981996824432 1.51429613366347e-05 NA NA NA hsa-miR-491-5p IGF2 -0.0339006601107336 0.849160118543586 -0.689838872603404 0.0793719101222569 MirTarget;miRanda -0.23363641435904 0.041783294320094 NA NA NA hsa-miR-877-5p IGF2 2.90093737151303 2.52134268016683e-35 -0.689838872603404 0.0793719101222569 miRNAWalker2_validate -0.197729933932355 0.0131473325758795 NA NA NA hsa-miR-93-5p IGF2 1.27151657903037 1.96654008726155e-14 -0.689838872603404 0.0793719101222569 miRNAWalker2_validate -0.44759191468925 0.000123227417807764 NA NA NA hsa-miR-125a-5p IKBKG -0.463931772449969 8.22426972811352e-05 0.308838265074477 0.00157617026300012 miRanda -0.120030230542781 0.00472383389586032 NA NA NA hsa-miR-140-5p IKBKG -0.615965395622439 1.05820583250804e-08 0.308838265074477 0.00157617026300012 miRanda -0.121048231942292 0.00866367766379721 NA NA NA hsa-miR-143-3p IKBKG -1.50460346732144 5.17074613336112e-23 0.308838265074477 0.00157617026300012 mirMAP -0.160528736055268 1.5618831428753e-07 NA NA NA hsa-miR-193a-3p IKBKG -0.399504718785393 0.0108866663328791 0.308838265074477 0.00157617026300012 miRanda -0.133193447334514 2.73523367931778e-05 NA NA NA hsa-miR-1976 IKBKG -1.13975694972151 3.52774818586224e-19 0.308838265074477 0.00157617026300012 mirMAP -0.122380507843302 0.00111670805456295 NA NA NA hsa-miR-29c-3p IKBKG -1.50225173284958 1.90087771871443e-16 0.308838265074477 0.00157617026300012 mirMAP -0.118747148467259 5.29514790574103e-06 NA NA NA hsa-miR-330-3p IKBKG 0.00879260240870505 0.951284239507664 0.308838265074477 0.00157617026300012 mirMAP -0.115758205335069 0.000915405961333507 NA NA NA hsa-miR-361-3p IKBKG -0.491157107537441 1.38504517485595e-06 0.308838265074477 0.00157617026300012 mirMAP -0.134790010088835 0.00612291550261469 NA NA NA hsa-miR-224-3p IL2RA 0.735089473712282 0.00175854245266733 0.509602425616155 0.0650032105696919 MirTarget -0.139522741617268 0.0213877109588269 NA NA NA hsa-miR-3065-3p IL2RA -2.06226461576987 1.18100208176622e-17 0.509602425616155 0.0650032105696919 MirTarget -0.266179128378768 1.56095327008308e-06 NA NA NA hsa-miR-500a-3p IL2RA 0.0997410457813883 0.420760746886716 0.509602425616155 0.0650032105696919 MirTarget -0.391236976432539 0.00065977437942045 NA NA NA hsa-let-7d-3p IL2RB 0.230054708420569 0.0554512005712208 -0.767812096411181 0.00057652973530576 mirMAP -0.217408274738996 0.0242448801308382 NA NA NA hsa-miR-30b-3p IL2RB -0.976858856774298 4.89616633369313e-08 -0.767812096411181 0.00057652973530576 mirMAP -0.199182739957257 0.00161020765525001 NA NA NA hsa-miR-421 IL2RB 1.16807936195133 1.4164941985739e-11 -0.767812096411181 0.00057652973530576 mirMAP -0.33436413491454 1.92003837937591e-07 NA NA NA hsa-miR-629-5p IL2RB 0.896078284709513 1.3248439450822e-08 -0.767812096411181 0.00057652973530576 mirMAP -0.268759689638739 0.000164028929695426 NA NA NA hsa-miR-421 IL2RG 1.16807936195133 1.4164941985739e-11 -1.25847076408619 9.19314571755942e-08 miRanda;miRNATAP -0.383449399074927 2.05220366516694e-08 NA NA NA hsa-miR-331-3p IL4R 0.954925871149262 2.04897100127988e-09 -0.740333610915455 3.7022115402774e-05 miRNAWalker2_validate -0.298186501792356 1.17872955265021e-07 NA NA NA hsa-miR-339-5p IL4R 0.695129802377533 1.42149990793285e-05 -0.740333610915455 3.7022115402774e-05 miRanda -0.242649613236179 2.0707762562906e-05 NA NA NA hsa-miR-429 IL4R 1.44127712764248 1.7824212712414e-11 -0.740333610915455 3.7022115402774e-05 miRNATAP -0.165272812645417 7.67673699343325e-05 NA NA NA hsa-miR-429 IL6 1.44127712764248 1.7824212712414e-11 -2.58317632955695 1.68202428065062e-13 miRanda -0.537613132392372 6.21827194193977e-11 NA NA NA hsa-miR-760 IL6 2.46800133673516 9.92808266371112e-19 -2.58317632955695 1.68202428065062e-13 MirTarget;miRNATAP -0.272178336475559 2.38546650382584e-05 NA NA NA hsa-miR-98-5p IL6 0.278359437335009 0.00921227131925612 -2.58317632955695 1.68202428065062e-13 miRNAWalker2_validate -0.465936966704082 0.00782190398022094 25277211 miR 98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL 6; We also found that IL-6 is a target gene of miR-98 and IL-6 represses miR-98 levels via the Stat3-NF-κB-lin28B pathway metastasis melanoma hsa-let-7i-5p IL6R 0.140484500715033 0.0901764941286614 -1.86087439870801 1.97983481529131e-21 miRNATAP -0.276566854266225 0.0347769629057844 NA NA NA hsa-miR-103a-2-5p IL6R 1.89326161187553 3.13008877983253e-17 -1.86087439870801 1.97983481529131e-21 mirMAP -0.269159589841525 2.57160192287338e-09 NA NA NA hsa-miR-106a-5p IL6R 0.887689359198128 2.74215376899957e-05 -1.86087439870801 1.97983481529131e-21 mirMAP -0.285344756396977 4.6610811194158e-09 NA NA NA hsa-miR-106b-5p IL6R 0.768146314773296 1.22330832259683e-08 -1.86087439870801 1.97983481529131e-21 mirMAP -0.709376213444669 3.73547910808965e-22 NA NA NA hsa-miR-129-5p IL6R 2.0409652261565 1.19491474689015e-07 -1.86087439870801 1.97983481529131e-21 mirMAP -0.115779278627795 1.55617747291832e-05 NA NA NA hsa-miR-130a-3p IL6R -0.124312418026753 0.382773698737926 -1.86087439870801 1.97983481529131e-21 mirMAP -0.160788781486239 0.0320319417855808 NA NA NA hsa-miR-130b-3p IL6R 2.60393336883065 1.5273795648739e-42 -1.86087439870801 1.97983481529131e-21 mirMAP -0.484514811430314 1.67019319376646e-25 NA NA NA hsa-miR-135b-5p IL6R 1.57294269928689 3.57109531929976e-09 -1.86087439870801 1.97983481529131e-21 mirMAP -0.177661487236154 4.00113170196193e-06 NA NA NA hsa-miR-141-3p IL6R 1.96958415696982 1.4648441542521e-24 -1.86087439870801 1.97983481529131e-21 MirTarget -0.406541847641043 2.50981001714486e-16 NA NA NA hsa-miR-141-5p IL6R 1.56175040137525 3.90005840349024e-20 -1.86087439870801 1.97983481529131e-21 MirTarget -0.35090445415661 1.59535845108359e-09 NA NA NA hsa-miR-17-5p IL6R 1.27106228457264 5.91314767482551e-14 -1.86087439870801 1.97983481529131e-21 mirMAP -0.463134642022476 2.27252145387633e-15 NA NA NA hsa-miR-182-5p IL6R 2.16789823981744 5.64205069446407e-26 -1.86087439870801 1.97983481529131e-21 mirMAP -0.408477018205127 5.33347103189087e-19 NA NA NA hsa-miR-186-5p IL6R 0.439819047090102 6.33375570167175e-05 -1.86087439870801 1.97983481529131e-21 mirMAP -0.341110639752077 0.000394143691413911 NA NA NA hsa-miR-192-5p IL6R 0.755837132896928 2.446089221206e-05 -1.86087439870801 1.97983481529131e-21 mirMAP -0.273756622633676 2.44904860126318e-06 NA NA NA hsa-miR-193b-3p IL6R 1.98352147870322 4.50184724470473e-22 -1.86087439870801 1.97983481529131e-21 mirMAP -0.145365839606005 0.00279840936324478 NA NA NA hsa-miR-197-3p IL6R 0.72925569501114 3.6335380891617e-08 -1.86087439870801 1.97983481529131e-21 MirTarget -0.371402217136723 2.09904318199911e-06 NA NA NA hsa-miR-200a-3p IL6R 1.41385743755862 3.01641811769439e-11 -1.86087439870801 1.97983481529131e-21 MirTarget -0.312681055775803 3.96465042284774e-11 NA NA NA hsa-miR-205-5p IL6R 7.4255450988826 2.64056553520099e-76 -1.86087439870801 1.97983481529131e-21 mirMAP -0.16619925229281 7.96610051574615e-16 NA NA NA hsa-miR-20a-5p IL6R 0.758237786270513 3.11867983980517e-05 -1.86087439870801 1.97983481529131e-21 mirMAP -0.341650858560602 1.612172409192e-09 NA NA NA hsa-miR-21-5p IL6R 1.07034578283768 3.39448630342548e-28 -1.86087439870801 1.97983481529131e-21 MirTarget;miRNATAP -0.342954259968578 0.000784409140914696 NA NA NA hsa-miR-28-5p IL6R 0.189534080376749 0.0278108067630943 -1.86087439870801 1.97983481529131e-21 mirMAP -0.52255078422717 2.72936353276005e-05 NA NA NA hsa-miR-301a-3p IL6R 1.23940945645189 2.05328421457283e-11 -1.86087439870801 1.97983481529131e-21 mirMAP -0.313513403521048 1.11985345403576e-08 NA NA NA hsa-miR-320a IL6R 0.25030125889857 0.0695425511666725 -1.86087439870801 1.97983481529131e-21 miRanda;miRNATAP -0.232423942535113 0.00258560658684298 NA NA NA hsa-miR-320b IL6R 1.16387990475466 1.33051259463572e-10 -1.86087439870801 1.97983481529131e-21 miRanda;miRNATAP -0.300176083140116 9.85162727795806e-08 NA NA NA hsa-miR-331-3p IL6R 0.954925871149262 2.04897100127988e-09 -1.86087439870801 1.97983481529131e-21 MirTarget -0.202397522270561 0.0019006465738636 NA NA NA hsa-miR-335-5p IL6R -0.324086861750615 0.0899025346373434 -1.86087439870801 1.97983481529131e-21 mirMAP -0.109739965780883 0.0484829435403561 NA NA NA hsa-miR-33a-5p IL6R 2.10005064969044 4.16515177092697e-18 -1.86087439870801 1.97983481529131e-21 mirMAP -0.251722733518553 7.49599544286242e-10 NA NA NA hsa-miR-33b-5p IL6R 2.17368974303808 7.43919661483659e-16 -1.86087439870801 1.97983481529131e-21 mirMAP -0.146955734421467 9.49563039915863e-05 NA NA NA hsa-miR-340-5p IL6R 0.172446891226333 0.176440862972852 -1.86087439870801 1.97983481529131e-21 mirMAP -0.322223024811495 0.000109395209827277 NA NA NA hsa-miR-3928-3p IL6R 1.65357644453037 7.50998419099203e-15 -1.86087439870801 1.97983481529131e-21 MirTarget -0.145387916497171 0.00328989261035532 NA NA NA hsa-miR-421 IL6R 1.16807936195133 1.4164941985739e-11 -1.86087439870801 1.97983481529131e-21 mirMAP -0.35156057938451 2.45726219790305e-09 NA NA NA hsa-miR-454-3p IL6R 0.942883363058312 9.73843658862518e-10 -1.86087439870801 1.97983481529131e-21 mirMAP -0.443853864842971 1.45329000279893e-11 NA NA NA hsa-miR-484 IL6R 0.290563207815661 0.0187067524486015 -1.86087439870801 1.97983481529131e-21 MirTarget -0.264954567645808 0.00210027139598756 NA NA NA hsa-miR-576-5p IL6R 0.993748428316612 2.24066125794743e-10 -1.86087439870801 1.97983481529131e-21 mirMAP -0.244595655237241 0.000207722633722093 NA NA NA hsa-miR-590-3p IL6R 0.9225805269779 6.0121446263776e-11 -1.86087439870801 1.97983481529131e-21 mirMAP -0.395451517196823 5.1251248018497e-08 NA NA NA hsa-miR-590-5p IL6R 1.22823897140696 7.5538778278798e-17 -1.86087439870801 1.97983481529131e-21 MirTarget;miRNATAP -0.427213926173579 2.78959130057822e-10 NA NA NA hsa-miR-708-3p IL6R 2.92078833427619 3.23244846700224e-40 -1.86087439870801 1.97983481529131e-21 mirMAP -0.243297864084708 9.78720331924583e-09 NA NA NA hsa-miR-93-5p IL6R 1.27151657903037 1.96654008726155e-14 -1.86087439870801 1.97983481529131e-21 mirMAP -0.517210698604798 1.64984936965786e-18 NA NA NA hsa-miR-942-5p IL6R 0.707804935292199 1.66243149466953e-05 -1.86087439870801 1.97983481529131e-21 MirTarget -0.314725927518076 6.45204616037772e-07 NA NA NA hsa-miR-98-5p IL6R 0.278359437335009 0.00921227131925612 -1.86087439870801 1.97983481529131e-21 miRNAWalker2_validate -0.21320551979373 0.0334219617376707 NA NA NA hsa-miR-129-5p IL7 2.0409652261565 1.19491474689015e-07 -1.52688917446842 6.95613929244778e-14 miRanda -0.137693723764237 4.07828727935795e-07 NA NA NA hsa-miR-192-5p IL7 0.755837132896928 2.446089221206e-05 -1.52688917446842 6.95613929244778e-14 miRNAWalker2_validate -0.157682411315908 0.00836880119051344 NA NA NA hsa-miR-335-3p IL7 0.462639143507351 0.00828753288457869 -1.52688917446842 6.95613929244778e-14 mirMAP -0.270965723141411 9.10619850456712e-06 NA NA NA hsa-miR-429 IL7 1.44127712764248 1.7824212712414e-11 -1.52688917446842 6.95613929244778e-14 miRanda -0.243121340758392 5.12547750128579e-07 NA NA NA hsa-miR-590-3p IL7 0.9225805269779 6.0121446263776e-11 -1.52688917446842 6.95613929244778e-14 miRanda -0.192687228951531 0.0103141440424187 NA NA NA hsa-miR-944 IL7 6.31318502943581 6.64615435406088e-56 -1.52688917446842 6.95613929244778e-14 mirMAP -0.174633511514306 5.29346846889061e-15 NA NA NA hsa-miR-129-5p IL7R 2.0409652261565 1.19491474689015e-07 -2.89903964493271 6.15878974297067e-20 miRanda;mirMAP -0.195269450137974 6.19185718482016e-06 NA NA NA hsa-miR-26b-5p IL7R -0.0183893267106221 0.882303333465809 -2.89903964493271 6.15878974297067e-20 miRNAWalker2_validate -0.28987139462502 0.0374417773350421 NA NA NA hsa-miR-335-3p IL7R 0.462639143507351 0.00828753288457869 -2.89903964493271 6.15878974297067e-20 mirMAP -0.716839430713689 3.02096856675689e-14 NA NA NA hsa-miR-450b-5p IL7R 1.40607004112146 2.03869814951451e-15 -2.89903964493271 6.15878974297067e-20 mirMAP -0.386740954170479 2.83950044877887e-05 NA NA NA hsa-miR-452-5p IL7R 1.08242667876786 2.34127628858457e-06 -2.89903964493271 6.15878974297067e-20 mirMAP -0.353584634884242 1.20253963949972e-06 NA NA NA hsa-miR-501-5p IL7R 0.316742767698094 0.0632047358679198 -2.89903964493271 6.15878974297067e-20 mirMAP -0.477410700842339 1.64091411554642e-06 NA NA NA hsa-miR-576-5p IL7R 0.993748428316612 2.24066125794743e-10 -2.89903964493271 6.15878974297067e-20 mirMAP -0.753809620309011 3.72552669466834e-13 NA NA NA hsa-miR-590-3p IL7R 0.9225805269779 6.0121446263776e-11 -2.89903964493271 6.15878974297067e-20 miRanda;mirMAP -0.727757617311783 4.1486195195619e-10 NA NA NA hsa-miR-7-1-3p IL7R 1.23074353429962 9.62692371802457e-18 -2.89903964493271 6.15878974297067e-20 mirMAP -0.957002919312741 2.0698444054047e-18 NA NA NA hsa-miR-15a-5p INSR -0.24629041301676 0.0253630661893983 -0.27382542985698 0.0324860286409356 miRNATAP -0.231834023278818 0.000103019582915445 NA NA NA hsa-miR-26b-5p INSR -0.0183893267106221 0.882303333465809 -0.27382542985698 0.0324860286409356 miRNAWalker2_validate -0.149304485008392 0.0050080511881119 21901137 IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-342-3p INSR 0.34628335679908 0.0121498405984511 -0.27382542985698 0.0324860286409356 miRanda -0.163870297175994 0.00054855335630371 NA NA NA hsa-miR-424-5p INSR 1.50572404087407 4.24425395615445e-20 -0.27382542985698 0.0324860286409356 miRNATAP -0.12182451785376 0.00130433017012809 NA NA NA hsa-miR-590-3p INSR 0.9225805269779 6.0121446263776e-11 -0.27382542985698 0.0324860286409356 PITA;miRanda;mirMAP;miRNATAP -0.121712528463863 0.00750931524037534 NA NA NA hsa-miR-590-5p INSR 1.22823897140696 7.5538778278798e-17 -0.27382542985698 0.0324860286409356 mirMAP -0.108779255495203 0.0109564215617161 NA NA NA hsa-miR-7-1-3p INSR 1.23074353429962 9.62692371802457e-18 -0.27382542985698 0.0324860286409356 mirMAP -0.107259975664027 0.0143716207293825 NA NA NA hsa-miR-128-3p IRS1 0.940275845868474 5.3111687457665e-10 0.493623374270242 0.0143932106536707 MirTarget -0.202361789204963 0.00247693089892008 26352220 In addition insulin receptor substrate 1 IRS1 a key mediator in oncogenic insulin-like growth factor IGF signaling was confirmed as a direct target of miR-128 by a luciferase reporter assay; Western blot analysis indicated that the overexpression of miR-128 significantly downregulated IRS1 expression and its downstream Akt signaling in CRC cells; Moreover miR-128 was negatively associated with IRS1 in CRC tissues compared to adjacent non-tumor tissues; Taken together these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1 metastasis colorectal cancer hsa-miR-142-5p IRS1 -0.0363288420100352 0.821716201807163 0.493623374270242 0.0143932106536707 MirTarget;PITA -0.225222245096441 0.000453457657917083 NA NA NA hsa-miR-16-1-3p IRS1 -0.156899711138322 0.214597270113743 0.493623374270242 0.0143932106536707 MirTarget -0.241247345314509 0.00340800108741529 NA NA NA hsa-miR-17-3p IRS1 -0.0552375132842826 0.669668193529718 0.493623374270242 0.0143932106536707 MirTarget -0.375360534684962 2.52076904308189e-06 NA NA NA hsa-miR-30b-5p IRS1 -1.50117013761001 1.78247435398346e-20 0.493623374270242 0.0143932106536707 MirTarget -0.135769905447199 0.0255156236116299 NA NA NA hsa-miR-30d-5p IRS1 -2.06908130936031 2.23574479943606e-47 0.493623374270242 0.0143932106536707 MirTarget;miRNATAP -0.184265973203533 0.00380351385522019 NA NA NA hsa-miR-30e-5p IRS1 0.186424244301373 0.077486249643257 0.493623374270242 0.0143932106536707 MirTarget -0.246164461431835 0.0130754807721929 NA NA NA hsa-miR-421 IRS1 1.16807936195133 1.4164941985739e-11 0.493623374270242 0.0143932106536707 PITA;miRanda;miRNATAP -0.174849598759603 0.00281460656574345 NA NA NA hsa-miR-660-5p IRS1 -0.701465625095864 2.01633605692768e-06 0.493623374270242 0.0143932106536707 MirTarget;miRNATAP -0.333656953232154 1.18768886289041e-06 NA NA NA hsa-miR-129-5p ITGA1 2.0409652261565 1.19491474689015e-07 -1.97704437509398 1.35854757319024e-26 miRanda -0.109419998457604 2.13321657547574e-05 NA NA NA hsa-miR-141-5p ITGA1 1.56175040137525 3.90005840349024e-20 -1.97704437509398 1.35854757319024e-26 MirTarget -0.528524398714528 7.60160250144926e-23 NA NA NA hsa-miR-186-5p ITGA1 0.439819047090102 6.33375570167175e-05 -1.97704437509398 1.35854757319024e-26 mirMAP -0.568757862093914 3.80455034990813e-10 NA NA NA hsa-miR-200a-5p ITGA1 1.8625149656411 2.00715507468494e-20 -1.97704437509398 1.35854757319024e-26 mirMAP -0.414434303250497 1.20338629229488e-19 NA NA NA hsa-miR-200b-3p ITGA1 1.24269422431788 9.2707509169586e-11 -1.97704437509398 1.35854757319024e-26 MirTarget -0.475218239905756 2.57706589531137e-22 NA NA NA hsa-miR-200b-5p ITGA1 2.1000866113144 2.48742582531618e-25 -1.97704437509398 1.35854757319024e-26 mirMAP -0.476157213940513 1.91437600752224e-27 NA NA NA hsa-miR-200c-3p ITGA1 1.44830286955223 1.39903737828795e-22 -1.97704437509398 1.35854757319024e-26 MirTarget -0.656409957538166 1.97664685978181e-27 NA NA NA hsa-miR-21-5p ITGA1 1.07034578283768 3.39448630342548e-28 -1.97704437509398 1.35854757319024e-26 mirMAP -0.308520926174083 0.00167162052455836 NA NA NA hsa-miR-320a ITGA1 0.25030125889857 0.0695425511666725 -1.97704437509398 1.35854757319024e-26 miRanda -0.279895677328317 0.000149528370848584 NA NA NA hsa-miR-320b ITGA1 1.16387990475466 1.33051259463572e-10 -1.97704437509398 1.35854757319024e-26 miRanda -0.287935668775925 1.01889154818213e-07 NA NA NA hsa-miR-335-3p ITGA1 0.462639143507351 0.00828753288457869 -1.97704437509398 1.35854757319024e-26 mirMAP -0.260681995845706 5.81623650890074e-06 NA NA NA hsa-miR-335-5p ITGA1 -0.324086861750615 0.0899025346373434 -1.97704437509398 1.35854757319024e-26 miRNAWalker2_validate -0.138748400513132 0.00924640654296082 NA NA NA hsa-miR-3607-3p ITGA1 0.797258097957342 0.000266170796527225 -1.97704437509398 1.35854757319024e-26 MirTarget -0.229428651936519 5.03889351062522e-07 NA NA NA hsa-miR-361-5p ITGA1 -0.0236974652105824 0.799888526193556 -1.97704437509398 1.35854757319024e-26 miRanda -0.320722968293906 0.00381064573015249 NA NA NA hsa-miR-362-3p ITGA1 -0.604045380242671 0.000132629619624125 -1.97704437509398 1.35854757319024e-26 miRanda -0.128400485320238 0.0465134747709294 NA NA NA hsa-miR-374a-5p ITGA1 -0.371522195407694 3.64288279697975e-05 -1.97704437509398 1.35854757319024e-26 mirMAP -0.264144827171497 0.0207970170900797 NA NA NA hsa-miR-374b-5p ITGA1 -0.490675710652087 1.35508117735881e-06 -1.97704437509398 1.35854757319024e-26 mirMAP -0.224195343777341 0.025459798814057 NA NA NA hsa-miR-421 ITGA1 1.16807936195133 1.4164941985739e-11 -1.97704437509398 1.35854757319024e-26 miRanda -0.473986829430983 9.27917253774636e-18 NA NA NA hsa-miR-429 ITGA1 1.44127712764248 1.7824212712414e-11 -1.97704437509398 1.35854757319024e-26 MirTarget;miRanda -0.461296400069381 9.22599153820155e-27 NA NA NA hsa-miR-452-5p ITGA1 1.08242667876786 2.34127628858457e-06 -1.97704437509398 1.35854757319024e-26 mirMAP -0.281281844249171 4.82948177221769e-11 NA NA NA hsa-miR-576-5p ITGA1 0.993748428316612 2.24066125794743e-10 -1.97704437509398 1.35854757319024e-26 mirMAP -0.490345253328185 1.22890062728045e-15 NA NA NA hsa-miR-590-3p ITGA1 0.9225805269779 6.0121446263776e-11 -1.97704437509398 1.35854757319024e-26 miRanda;mirMAP -0.549817932234715 7.04246031751433e-16 NA NA NA hsa-miR-590-5p ITGA1 1.22823897140696 7.5538778278798e-17 -1.97704437509398 1.35854757319024e-26 miRanda;mirMAP -0.615470121987391 9.52283907947822e-23 NA NA NA hsa-miR-664a-3p ITGA1 0.131764091487629 0.242680083678861 -1.97704437509398 1.35854757319024e-26 mirMAP -0.358250276970408 7.89018862620217e-05 NA NA NA hsa-miR-7-1-3p ITGA1 1.23074353429962 9.62692371802457e-18 -1.97704437509398 1.35854757319024e-26 mirMAP -0.617854344288524 8.56023789793692e-22 NA NA NA hsa-miR-944 ITGA1 6.31318502943581 6.64615435406088e-56 -1.97704437509398 1.35854757319024e-26 mirMAP -0.225867280742965 5.28335395974721e-29 NA NA NA hsa-let-7g-3p ITGA10 0.994803580752051 2.60686235393095e-10 -2.94021259102184 4.64891122562444e-40 MirTarget;miRNATAP -0.398481822965795 3.06108084241413e-07 NA NA NA hsa-miR-15b-5p ITGA10 0.575042920336974 9.75508983626876e-06 -2.94021259102184 4.64891122562444e-40 MirTarget -0.367964051212128 0.000138156400415729 NA NA NA hsa-miR-16-5p ITGA10 0.200674510503047 0.0593717079356147 -2.94021259102184 4.64891122562444e-40 MirTarget -0.27118340127043 0.0245354697733047 NA NA NA hsa-miR-28-5p ITGA10 0.189534080376749 0.0278108067630943 -2.94021259102184 4.64891122562444e-40 MirTarget;miRanda -0.326062718823586 0.0299443993811184 NA NA NA hsa-miR-320b ITGA10 1.16387990475466 1.33051259463572e-10 -2.94021259102184 4.64891122562444e-40 miRanda -0.278905736775346 3.94713484551409e-05 NA NA NA hsa-miR-324-5p ITGA10 1.21634042749489 1.07503319022833e-13 -2.94021259102184 4.64891122562444e-40 miRanda;miRNATAP -0.565667092233111 5.6432719303106e-15 NA NA NA hsa-miR-424-5p ITGA10 1.50572404087407 4.24425395615445e-20 -2.94021259102184 4.64891122562444e-40 MirTarget -0.42922128491022 2.66423876537122e-09 NA NA NA hsa-miR-429 ITGA10 1.44127712764248 1.7824212712414e-11 -2.94021259102184 4.64891122562444e-40 miRanda;miRNATAP -0.322475895836509 1.16649463825957e-08 NA NA NA hsa-miR-484 ITGA10 0.290563207815661 0.0187067524486015 -2.94021259102184 4.64891122562444e-40 miRNATAP -0.228318963544789 0.0270977897677732 NA NA NA hsa-miR-616-5p ITGA10 2.3596511369846 3.26881700557061e-22 -2.94021259102184 4.64891122562444e-40 mirMAP;miRNATAP -0.360160838897034 2.2263700726198e-13 NA NA NA hsa-miR-708-5p ITGA10 3.70808687333578 5.51249219545358e-54 -2.94021259102184 4.64891122562444e-40 MirTarget -0.476260040727908 1.51726191799565e-29 NA NA NA hsa-miR-940 ITGA10 1.91696621517233 1.3556247816872e-17 -2.94021259102184 4.64891122562444e-40 MirTarget;miRNATAP -0.390655238479956 8.65238402721122e-14 NA NA NA hsa-miR-29a-3p ITGA11 -1.03082784302378 5.4721714495133e-16 1.95507709555059 4.39282486679225e-10 miRNAWalker2_validate;miRTarBase -0.285638862324729 0.0221942517458839 NA NA NA hsa-miR-34c-5p ITGA11 -1.65096032312419 3.10893885639741e-06 1.95507709555059 4.39282486679225e-10 miRanda -0.181684264502527 6.36735996201395e-05 NA NA NA hsa-miR-421 ITGA11 1.16807936195133 1.4164941985739e-11 1.95507709555059 4.39282486679225e-10 mirMAP -0.346747286712035 0.000182279853672521 NA NA NA hsa-miR-429 ITGA11 1.44127712764248 1.7824212712414e-11 1.95507709555059 4.39282486679225e-10 miRNATAP -0.235712555174489 0.00152677837387029 NA NA NA hsa-miR-532-5p ITGA11 -0.485749465832866 0.000138169498131266 1.95507709555059 4.39282486679225e-10 miRNATAP -0.926520833632365 1.14322128704772e-13 NA NA NA hsa-miR-107 ITGA2 -0.456345046928702 5.29231946717953e-06 1.32693491740026 2.37837031524142e-11 MirTarget;miRanda;miRNATAP -0.422023003873719 4.75933358366941e-05 NA NA NA hsa-miR-126-5p ITGA2 -1.94634635849451 2.4038399235921e-37 1.32693491740026 2.37837031524142e-11 mirMAP -0.42005123744759 3.63602427390819e-12 NA NA NA hsa-miR-130a-3p ITGA2 -0.124312418026753 0.382773698737926 1.32693491740026 2.37837031524142e-11 mirMAP -0.239951144255873 0.00111423904797977 NA NA NA hsa-miR-139-5p ITGA2 -2.25560964518719 9.95317711940085e-30 1.32693491740026 2.37837031524142e-11 PITA;miRanda -0.284123808017872 2.21989921485136e-09 NA NA NA hsa-miR-142-3p ITGA2 0.674575513897478 0.000112525767514321 1.32693491740026 2.37837031524142e-11 miRanda -0.174136692342648 0.0033502289081075 NA NA NA hsa-miR-15a-5p ITGA2 -0.24629041301676 0.0253630661893983 1.32693491740026 2.37837031524142e-11 MirTarget;miRNATAP -0.258246444406165 0.00696418991663855 NA NA NA hsa-miR-16-5p ITGA2 0.200674510503047 0.0593717079356147 1.32693491740026 2.37837031524142e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.404826664975002 4.04901551173783e-05 NA NA NA hsa-miR-181a-5p ITGA2 -1.31879909071317 2.04570351303734e-24 1.32693491740026 2.37837031524142e-11 MirTarget -0.311555194166369 3.79007117330704e-05 NA NA NA hsa-miR-181b-5p ITGA2 -0.578702702808657 2.41220004393722e-05 1.32693491740026 2.37837031524142e-11 MirTarget -0.189976254840988 0.0123303626595799 NA NA NA hsa-miR-181c-5p ITGA2 -1.36921360773694 5.61046203952059e-19 1.32693491740026 2.37837031524142e-11 MirTarget -0.405388835466457 1.60967991280788e-10 NA NA NA hsa-miR-181d-5p ITGA2 -0.225424526304381 0.151955641871942 1.32693491740026 2.37837031524142e-11 MirTarget -0.209181799479563 0.00168232225352343 NA NA NA hsa-miR-186-5p ITGA2 0.439819047090102 6.33375570167175e-05 1.32693491740026 2.37837031524142e-11 mirMAP -0.457168098320381 1.20283630815471e-06 NA NA NA hsa-miR-18a-5p ITGA2 0.941249745535531 1.37246345065862e-06 1.32693491740026 2.37837031524142e-11 MirTarget -0.133842789904396 0.0114319660294355 NA NA NA hsa-miR-195-5p ITGA2 -1.62452829530841 2.94084397454942e-29 1.32693491740026 2.37837031524142e-11 MirTarget;miRNATAP -0.301461500494428 5.58530625741133e-06 NA NA NA hsa-miR-26a-5p ITGA2 -0.929312251092796 7.48452512025337e-23 1.32693491740026 2.37837031524142e-11 mirMAP -0.573660906100905 3.49720797071862e-08 NA NA NA hsa-miR-26b-5p ITGA2 -0.0183893267106221 0.882303333465809 1.32693491740026 2.37837031524142e-11 mirMAP -0.302493367099175 0.000347590109773036 NA NA NA hsa-miR-3065-5p ITGA2 -0.963317497666877 0.000100334146005009 1.32693491740026 2.37837031524142e-11 mirMAP -0.1131768397208 0.00723691970890973 NA NA NA hsa-miR-30a-5p ITGA2 -2.98793938555326 1.93840183838367e-49 1.32693491740026 2.37837031524142e-11 miRNAWalker2_validate;mirMAP -0.240296858094166 6.65366513482339e-08 NA NA NA hsa-miR-30b-5p ITGA2 -1.50117013761001 1.78247435398346e-20 1.32693491740026 2.37837031524142e-11 mirMAP -0.340424251530923 1.65795218401702e-08 NA NA NA hsa-miR-30c-5p ITGA2 -0.426804145561029 0.00403132854321475 1.32693491740026 2.37837031524142e-11 mirMAP -0.290396845296209 3.28563773748363e-05 NA NA NA hsa-miR-30d-5p ITGA2 -2.06908130936031 2.23574479943606e-47 1.32693491740026 2.37837031524142e-11 mirMAP -0.410402585578288 6.68797529819738e-11 NA NA NA hsa-miR-30e-5p ITGA2 0.186424244301373 0.077486249643257 1.32693491740026 2.37837031524142e-11 mirMAP -0.550898997968917 2.25547188913654e-08 NA NA NA hsa-miR-326 ITGA2 -2.468565451901 1.23182221778132e-19 1.32693491740026 2.37837031524142e-11 PITA -0.248500026632654 2.71018969346856e-12 NA NA NA hsa-miR-330-5p ITGA2 0.168243129357275 0.239196436552122 1.32693491740026 2.37837031524142e-11 PITA -0.145182434685034 0.0486437791192454 NA NA NA hsa-miR-335-5p ITGA2 -0.324086861750615 0.0899025346373434 1.32693491740026 2.37837031524142e-11 miRNAWalker2_validate -0.2289709417634 2.48334181005006e-05 NA NA NA hsa-miR-340-5p ITGA2 0.172446891226333 0.176440862972852 1.32693491740026 2.37837031524142e-11 mirMAP -0.311032825749567 0.00015173515293991 NA NA NA hsa-miR-3607-3p ITGA2 0.797258097957342 0.000266170796527225 1.32693491740026 2.37837031524142e-11 mirMAP -0.116776489035995 0.0138496921305348 NA NA NA hsa-miR-362-3p ITGA2 -0.604045380242671 0.000132629619624125 1.32693491740026 2.37837031524142e-11 miRanda -0.295376662161028 6.44515637560096e-06 NA NA NA hsa-miR-374a-5p ITGA2 -0.371522195407694 3.64288279697975e-05 1.32693491740026 2.37837031524142e-11 MirTarget -0.711608969934275 5.56680203775662e-10 NA NA NA hsa-miR-374b-5p ITGA2 -0.490675710652087 1.35508117735881e-06 1.32693491740026 2.37837031524142e-11 MirTarget -0.610881600162256 1.38069548344427e-09 NA NA NA hsa-miR-497-5p ITGA2 -1.37093122385312 2.06413037457593e-23 1.32693491740026 2.37837031524142e-11 MirTarget;miRNATAP -0.234038930067984 0.00107144163321997 NA NA NA hsa-miR-532-5p ITGA2 -0.485749465832866 0.000138169498131266 1.32693491740026 2.37837031524142e-11 MirTarget -0.41150051395458 3.6230875801549e-07 NA NA NA hsa-miR-582-5p ITGA2 -0.0134667168827214 0.939685711149187 1.32693491740026 2.37837031524142e-11 MirTarget;PITA -0.171115635164914 0.00362688394490387 NA NA NA hsa-miR-129-5p ITGA3 2.0409652261565 1.19491474689015e-07 -0.897596592097007 6.01725634465749e-05 MirTarget -0.149422487938229 2.70299358791647e-07 NA NA NA hsa-miR-181c-5p ITGA3 -1.36921360773694 5.61046203952059e-19 -0.897596592097007 6.01725634465749e-05 miRNATAP -0.148904485172959 0.0381208912206704 NA NA NA hsa-miR-186-5p ITGA3 0.439819047090102 6.33375570167175e-05 -0.897596592097007 6.01725634465749e-05 miRNATAP -0.411095210216155 8.61036355852419e-05 NA NA NA hsa-miR-28-5p ITGA3 0.189534080376749 0.0278108067630943 -0.897596592097007 6.01725634465749e-05 miRanda -0.75781624823273 1.75429737286039e-08 NA NA NA hsa-miR-548v ITGA3 1.38314663277825 1.32637772795382e-09 -0.897596592097007 6.01725634465749e-05 miRNATAP -0.213585599156663 5.55405411476986e-05 NA NA NA hsa-miR-616-3p ITGA3 1.84210973859322 4.49541996670696e-19 -0.897596592097007 6.01725634465749e-05 mirMAP -0.170978768110179 0.00269052347757942 NA NA NA hsa-miR-760 ITGA3 2.46800133673516 9.92808266371112e-19 -0.897596592097007 6.01725634465749e-05 miRNATAP -0.193027071291288 1.35613737596975e-06 NA NA NA hsa-miR-940 ITGA3 1.91696621517233 1.3556247816872e-17 -0.897596592097007 6.01725634465749e-05 miRNATAP -0.230025884010869 2.4099011066315e-06 NA NA NA hsa-miR-17-5p ITGA4 1.27106228457264 5.91314767482551e-14 -1.24503400936581 3.45733284611378e-09 TargetScan -0.438573635352137 7.47437165608281e-13 NA NA NA hsa-miR-320b ITGA4 1.16387990475466 1.33051259463572e-10 -1.24503400936581 3.45733284611378e-09 miRanda -0.16272709239972 0.00609244390899041 NA NA NA hsa-miR-339-5p ITGA4 0.695129802377533 1.42149990793285e-05 -1.24503400936581 3.45733284611378e-09 miRanda -0.367788236115039 4.46059217761978e-08 NA NA NA hsa-miR-362-3p ITGA4 -0.604045380242671 0.000132629619624125 -1.24503400936581 3.45733284611378e-09 miRanda -0.204397673926456 0.00330443878280169 NA NA NA hsa-miR-590-3p ITGA4 0.9225805269779 6.0121446263776e-11 -1.24503400936581 3.45733284611378e-09 miRanda -0.400023197709408 1.17417601458657e-07 NA NA NA hsa-miR-107 ITGA5 -0.456345046928702 5.29231946717953e-06 -0.575415118426246 0.0010373698070477 PITA;miRanda -0.442891092258367 6.73793703455646e-07 NA NA NA hsa-miR-148a-3p ITGA5 0.601028293839963 9.92248185893877e-05 -0.575415118426246 0.0010373698070477 miRNATAP -0.160802408584849 0.00565920834504224 NA NA NA hsa-miR-148b-3p ITGA5 0.0385421182152106 0.68086754032186 -0.575415118426246 0.0010373698070477 miRNAWalker2_validate -0.588358803617165 9.30741771699334e-10 27328731 Notably transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR-214 or miR-148b could be overridden by overexpression of ITGA5 or ALCAM in the same tumor cells melanoma hsa-miR-183-5p ITGA5 2.81472476144496 4.67808720273896e-39 -0.575415118426246 0.0010373698070477 miRNAWalker2_validate -0.265053039768276 4.11928225072937e-13 NA NA NA hsa-miR-25-3p ITGA5 0.324190582599831 0.0073283146172755 -0.575415118426246 0.0010373698070477 miRNATAP -0.564155516718839 6.76566257473046e-15 NA NA NA hsa-miR-26b-5p ITGA5 -0.0183893267106221 0.882303333465809 -0.575415118426246 0.0010373698070477 miRNATAP -0.17333872242746 0.01816992182399 NA NA NA hsa-miR-27b-3p ITGA5 0.0774984459252845 0.455541249499373 -0.575415118426246 0.0010373698070477 miRNATAP -0.281959757956335 0.00134101018355675 NA NA NA hsa-miR-28-5p ITGA5 0.189534080376749 0.0278108067630943 -0.575415118426246 0.0010373698070477 PITA;miRanda -0.60618498358142 7.57014179833534e-09 NA NA NA hsa-miR-30c-5p ITGA5 -0.426804145561029 0.00403132854321475 -0.575415118426246 0.0010373698070477 miRNATAP -0.244633790348111 5.15592934136775e-05 NA NA NA hsa-miR-32-5p ITGA5 -0.349953074737666 0.00689126382132822 -0.575415118426246 0.0010373698070477 miRNATAP -0.396726380019573 7.72484660044353e-09 NA NA NA hsa-miR-429 ITGA5 1.44127712764248 1.7824212712414e-11 -0.575415118426246 0.0010373698070477 miRNATAP -0.279422834466973 2.2105469567934e-12 NA NA NA hsa-miR-484 ITGA5 0.290563207815661 0.0187067524486015 -0.575415118426246 0.0010373698070477 miRNAWalker2_validate -0.318796734613298 1.20636562741525e-05 NA NA NA hsa-miR-629-3p ITGA5 2.47046856327102 4.17622167602811e-39 -0.575415118426246 0.0010373698070477 miRNATAP -0.222242216466228 1.58461293123642e-07 NA NA NA hsa-miR-760 ITGA5 2.46800133673516 9.92808266371112e-19 -0.575415118426246 0.0010373698070477 miRNATAP -0.164246561679693 1.29256396237789e-07 NA NA NA hsa-miR-92a-3p ITGA5 0.779792182638042 4.45572871602003e-09 -0.575415118426246 0.0010373698070477 miRNAWalker2_validate;miRTarBase;miRNATAP -0.398640874125252 1.19877796469517e-09 23499550 The level of miR-92a expression was significantly inversely correlated with ITGA5 expression in various cancer cells; miR-92a overexpression reduced the luciferase activity of the ITGA5 3'-untranslated region suggesting that ITGA5 mRNA is a direct target of miR-92a ovarian cancer hsa-miR-92b-3p ITGA5 0.660348894715342 5.8183923925395e-06 -0.575415118426246 0.0010373698070477 miRNATAP -0.1633386895517 0.00787044264232348 NA NA NA hsa-miR-98-5p ITGA5 0.278359437335009 0.00921227131925612 -0.575415118426246 0.0010373698070477 miRNAWalker2_validate -0.401000287970206 1.96274149614032e-06 NA NA NA hsa-miR-186-5p ITGA6 0.439819047090102 6.33375570167175e-05 1.52599149510033 6.49067211736548e-14 mirMAP -0.297179276670999 0.00246072316822203 NA NA NA hsa-miR-217 ITGA6 -0.501449190998853 0.0366805136279841 1.52599149510033 6.49067211736548e-14 miRanda -0.25463675209403 7.51979445376e-09 NA NA NA hsa-miR-30a-5p ITGA6 -2.98793938555326 1.93840183838367e-49 1.52599149510033 6.49067211736548e-14 miRNAWalker2_validate -0.323181231786508 9.67103630079854e-13 NA NA NA hsa-miR-32-5p ITGA6 -0.349953074737666 0.00689126382132822 1.52599149510033 6.49067211736548e-14 miRNAWalker2_validate -0.283939734583351 0.000654125389601779 NA NA NA hsa-miR-335-3p ITGA6 0.462639143507351 0.00828753288457869 1.52599149510033 6.49067211736548e-14 mirMAP -0.150277871567828 0.0145648356444687 NA NA NA hsa-miR-338-5p ITGA6 -2.99778534642888 2.74111905046628e-39 1.52599149510033 6.49067211736548e-14 PITA;mirMAP -0.315957604656812 1.71687740246086e-14 NA NA NA hsa-miR-342-3p ITGA6 0.34628335679908 0.0121498405984511 1.52599149510033 6.49067211736548e-14 miRanda -0.3021360145912 0.000105423721254651 NA NA NA hsa-miR-34a-5p ITGA6 -0.43794334019748 0.000117590706048968 1.52599149510033 6.49067211736548e-14 miRNAWalker2_validate -0.44175553165144 2.65264280144954e-06 NA NA NA hsa-miR-339-5p ITGA7 0.695129802377533 1.42149990793285e-05 -1.33940687582804 1.20619809973282e-12 miRanda -0.258593057287303 2.39534523870601e-05 NA NA NA hsa-miR-130b-3p ITGA8 2.60393336883065 1.5273795648739e-42 -5.02682525193694 2.07273692235378e-34 mirMAP -1.21206560995544 9.34935415453378e-35 NA NA NA hsa-miR-183-5p ITGA8 2.81472476144496 4.67808720273896e-39 -5.02682525193694 2.07273692235378e-34 miRNAWalker2_validate -0.970988751951079 3.34297919183179e-27 NA NA NA hsa-miR-19b-1-5p ITGA8 0.550369246540305 0.000830309981399621 -5.02682525193694 2.07273692235378e-34 mirMAP -0.846961972367061 6.46377155577286e-10 NA NA NA hsa-miR-21-5p ITGA8 1.07034578283768 3.39448630342548e-28 -5.02682525193694 2.07273692235378e-34 mirMAP -1.69040439900777 4.30899984486265e-15 NA NA NA hsa-miR-301a-3p ITGA8 1.23940945645189 2.05328421457283e-11 -5.02682525193694 2.07273692235378e-34 mirMAP -0.999246040489998 9.99411955447038e-18 NA NA NA hsa-miR-335-3p ITGA8 0.462639143507351 0.00828753288457869 -5.02682525193694 2.07273692235378e-34 mirMAP -0.448360469170061 0.000639710500288865 NA NA NA hsa-miR-33a-5p ITGA8 2.10005064969044 4.16515177092697e-18 -5.02682525193694 2.07273692235378e-34 mirMAP -0.772792571879704 5.46446296097249e-19 NA NA NA hsa-miR-409-3p ITGA8 1.50279965466975 5.59874611887893e-12 -5.02682525193694 2.07273692235378e-34 mirMAP -0.296299213604289 0.00393692718090849 NA NA NA hsa-miR-454-3p ITGA8 0.942883363058312 9.73843658862518e-10 -5.02682525193694 2.07273692235378e-34 mirMAP -1.08920623819272 1.77530682368071e-14 NA NA NA hsa-miR-577 ITGA8 3.5197399300515 1.67960995324817e-16 -5.02682525193694 2.07273692235378e-34 mirMAP -0.297617370303829 2.09108480425764e-07 NA NA NA hsa-miR-590-5p ITGA8 1.22823897140696 7.5538778278798e-17 -5.02682525193694 2.07273692235378e-34 mirMAP -1.27613780877256 7.65456816124522e-19 NA NA NA hsa-miR-7-1-3p ITGA8 1.23074353429962 9.62692371802457e-18 -5.02682525193694 2.07273692235378e-34 mirMAP -1.15581936112042 9.62188470946233e-15 NA NA NA hsa-miR-944 ITGA8 6.31318502943581 6.64615435406088e-56 -5.02682525193694 2.07273692235378e-34 mirMAP -0.565138169886278 2.89148737942306e-36 NA NA NA hsa-miR-103a-2-5p ITGA9 1.89326161187553 3.13008877983253e-17 -2.84616938359804 1.40551128319437e-22 mirMAP -0.477245609836299 8.84649560139396e-13 NA NA NA hsa-miR-141-5p ITGA9 1.56175040137525 3.90005840349024e-20 -2.84616938359804 1.40551128319437e-22 MirTarget -0.722919315277762 1.52313883884996e-17 NA NA NA hsa-miR-200b-3p ITGA9 1.24269422431788 9.2707509169586e-11 -2.84616938359804 1.40551128319437e-22 mirMAP -0.49180106624106 4.32992470834121e-10 24518294;26334393 β1 integrin inhibition elicits a prometastatic switch through the TGFβ miR 200 ZEB network in E cadherin positive triple negative breast cancer;We revealed that miR-200b suppresses the integrin β1-AKT pathway via targeting Kindlin-2 to mitigate ESCC cell invasiveness ; breast cancer;esophageal cancer hsa-miR-20a-3p ITGA9 1.79890197957803 9.4283425564752e-24 -2.84616938359804 1.40551128319437e-22 mirMAP -0.620286454842143 1.09282328476186e-14 NA NA NA hsa-miR-324-5p ITGA9 1.21634042749489 1.07503319022833e-13 -2.84616938359804 1.40551128319437e-22 miRanda -0.639488404762293 2.22849400340716e-12 NA NA NA hsa-miR-33a-3p ITGA9 0.540032749009224 0.00270907254062352 -2.84616938359804 1.40551128319437e-22 mirMAP -0.35317199324543 6.15116993057976e-05 NA NA NA hsa-miR-33a-5p ITGA9 2.10005064969044 4.16515177092697e-18 -2.84616938359804 1.40551128319437e-22 mirMAP -0.495283478363835 1.28522590365357e-16 NA NA NA hsa-miR-33b-5p ITGA9 2.17368974303808 7.43919661483659e-16 -2.84616938359804 1.40551128319437e-22 mirMAP -0.41127498158773 5.60955757450949e-14 NA NA NA hsa-miR-421 ITGA9 1.16807936195133 1.4164941985739e-11 -2.84616938359804 1.40551128319437e-22 mirMAP -0.522444174350234 2.91976419204455e-09 NA NA NA hsa-miR-429 ITGA9 1.44127712764248 1.7824212712414e-11 -2.84616938359804 1.40551128319437e-22 miRanda -0.485701837010484 3.59009464298425e-12 NA NA NA hsa-miR-452-3p ITGA9 1.41409839510389 1.17526115748788e-07 -2.84616938359804 1.40551128319437e-22 MirTarget -0.369254631682099 9.05671294268895e-11 NA NA NA hsa-miR-452-5p ITGA9 1.08242667876786 2.34127628858457e-06 -2.84616938359804 1.40551128319437e-22 mirMAP -0.391822707536827 4.66994247551794e-09 NA NA NA hsa-miR-501-5p ITGA9 0.316742767698094 0.0632047358679198 -2.84616938359804 1.40551128319437e-22 MirTarget -0.303257935925562 0.00109222191548479 NA NA NA hsa-miR-576-5p ITGA9 0.993748428316612 2.24066125794743e-10 -2.84616938359804 1.40551128319437e-22 mirMAP -0.492654792664513 4.5723686810363e-07 NA NA NA hsa-miR-589-3p ITGA9 1.64129600791754 3.03909323325799e-16 -2.84616938359804 1.40551128319437e-22 mirMAP -0.526625051935891 9.31860595101213e-13 NA NA NA hsa-miR-590-3p ITGA9 0.9225805269779 6.0121446263776e-11 -2.84616938359804 1.40551128319437e-22 miRanda -0.602365482875842 2.65861210330055e-08 NA NA NA hsa-miR-590-5p ITGA9 1.22823897140696 7.5538778278798e-17 -2.84616938359804 1.40551128319437e-22 miRanda -0.730921160407647 2.98536128986291e-13 NA NA NA hsa-miR-616-5p ITGA9 2.3596511369846 3.26881700557061e-22 -2.84616938359804 1.40551128319437e-22 mirMAP -0.437143055135933 1.11778115106114e-12 NA NA NA hsa-miR-664a-3p ITGA9 0.131764091487629 0.242680083678861 -2.84616938359804 1.40551128319437e-22 MirTarget -0.431221545603535 0.00233444865565707 NA NA NA hsa-miR-877-5p ITGA9 2.90093737151303 2.52134268016683e-35 -2.84616938359804 1.40551128319437e-22 mirMAP -0.483584676188781 1.07364063555917e-15 NA NA NA hsa-miR-142-5p ITGAV -0.0363288420100352 0.821716201807163 0.741351068966704 4.5782925621469e-08 MirTarget;PITA -0.116169156243472 0.00821988054380612 NA NA NA hsa-miR-16-2-3p ITGAV 0.505774348451832 0.00083906759991608 0.741351068966704 4.5782925621469e-08 mirMAP -0.238523038337403 2.010198657455e-07 NA NA NA hsa-miR-186-5p ITGAV 0.439819047090102 6.33375570167175e-05 0.741351068966704 4.5782925621469e-08 mirMAP -0.268979615345803 2.51338550173539e-05 NA NA NA hsa-miR-192-5p ITGAV 0.755837132896928 2.446089221206e-05 0.741351068966704 4.5782925621469e-08 miRNAWalker2_validate;MirTarget -0.141090798139638 0.000285864806363119 NA NA NA hsa-miR-215-5p ITGAV 0.0254649649861296 0.894392504053362 0.741351068966704 4.5782925621469e-08 miRNAWalker2_validate;MirTarget -0.11919644323895 0.00127526063417641 NA NA NA hsa-miR-25-3p ITGAV 0.324190582599831 0.0073283146172755 0.741351068966704 4.5782925621469e-08 MirTarget;miRNATAP -0.267821138119446 4.05451689505582e-06 NA NA NA hsa-miR-30e-3p ITGAV -0.568615785445122 1.6997540158547e-07 0.741351068966704 4.5782925621469e-08 mirMAP -0.247210881335951 0.000118180554847817 NA NA NA hsa-miR-32-5p ITGAV -0.349953074737666 0.00689126382132822 0.741351068966704 4.5782925621469e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.423509656336577 8.6701445268794e-16 NA NA NA hsa-miR-331-5p ITGAV 0.782866941570431 7.91287242315309e-09 0.741351068966704 4.5782925621469e-08 PITA -0.124915740229584 0.0148584362496864 NA NA NA hsa-miR-335-3p ITGAV 0.462639143507351 0.00828753288457869 0.741351068966704 4.5782925621469e-08 MirTarget -0.197634971005205 6.60817301890661e-07 NA NA NA hsa-miR-33a-3p ITGAV 0.540032749009224 0.00270907254062352 0.741351068966704 4.5782925621469e-08 MirTarget -0.105388393318611 0.00766801410719911 NA NA NA hsa-miR-340-5p ITGAV 0.172446891226333 0.176440862972852 0.741351068966704 4.5782925621469e-08 MirTarget -0.233107009666104 2.51711612788979e-05 NA NA NA hsa-miR-361-5p ITGAV -0.0236974652105824 0.799888526193556 0.741351068966704 4.5782925621469e-08 MirTarget;miRanda -0.260527085724881 0.000677339923759451 NA NA NA hsa-miR-363-3p ITGAV -0.318588561792557 0.232403434324873 0.741351068966704 4.5782925621469e-08 MirTarget -0.18186966695707 1.67900853165892e-12 NA NA NA hsa-miR-374a-5p ITGAV -0.371522195407694 3.64288279697975e-05 0.741351068966704 4.5782925621469e-08 mirMAP -0.453638655992871 5.29448896826776e-09 NA NA NA hsa-miR-374b-5p ITGAV -0.490675710652087 1.35508117735881e-06 0.741351068966704 4.5782925621469e-08 mirMAP -0.479365396915758 1.23301713957686e-12 NA NA NA hsa-miR-550a-3p ITGAV 0.725364459738765 3.06985443364331e-05 0.741351068966704 4.5782925621469e-08 miRNATAP -0.155456066887254 0.000117356234871766 NA NA NA hsa-miR-582-3p ITGAV -0.459710681681138 0.0173047578986498 0.741351068966704 4.5782925621469e-08 MirTarget -0.161714890928872 7.764880169006e-06 NA NA NA hsa-miR-590-3p ITGAV 0.9225805269779 6.0121446263776e-11 0.741351068966704 4.5782925621469e-08 MirTarget;PITA;miRanda -0.122178627919886 0.0127724421321026 NA NA NA hsa-miR-7-1-3p ITGAV 1.23074353429962 9.62692371802457e-18 0.741351068966704 4.5782925621469e-08 mirMAP -0.184173184371914 8.61077473563065e-05 NA NA NA hsa-miR-92a-3p ITGAV 0.779792182638042 4.45572871602003e-09 0.741351068966704 4.5782925621469e-08 MirTarget;miRNATAP -0.241061521952064 3.23963569880451e-06 NA NA NA hsa-miR-16-2-3p ITGB1 0.505774348451832 0.00083906759991608 -0.32912884903585 0.00358090194706874 mirMAP -0.26847851191467 4.20250143786367e-13 NA NA NA hsa-miR-183-5p ITGB1 2.81472476144496 4.67808720273896e-39 -0.32912884903585 0.00358090194706874 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.12911001315344 5.91634375311644e-08 NA NA NA hsa-miR-186-5p ITGB1 0.439819047090102 6.33375570167175e-05 -0.32912884903585 0.00358090194706874 miRNAWalker2_validate -0.247617888503349 2.12653611223917e-06 NA NA NA hsa-miR-192-5p ITGB1 0.755837132896928 2.446089221206e-05 -0.32912884903585 0.00358090194706874 miRNAWalker2_validate -0.198973087415268 2.22025727020971e-10 NA NA NA hsa-miR-25-3p ITGB1 0.324190582599831 0.0073283146172755 -0.32912884903585 0.00358090194706874 miRNAWalker2_validate -0.296650532918728 3.07450631745107e-10 NA NA NA hsa-miR-3607-3p ITGB1 0.797258097957342 0.000266170796527225 -0.32912884903585 0.00358090194706874 MirTarget -0.11389010913586 1.25497213463781e-05 NA NA NA hsa-miR-374b-3p ITGB1 0.166291930194592 0.223712737750778 -0.32912884903585 0.00358090194706874 MirTarget -0.136714558213984 0.00144780878913693 NA NA NA hsa-miR-429 ITGB1 1.44127712764248 1.7824212712414e-11 -0.32912884903585 0.00358090194706874 miRanda -0.156065565557312 1.36222308388186e-09 NA NA NA hsa-miR-590-3p ITGB1 0.9225805269779 6.0121446263776e-11 -0.32912884903585 0.00358090194706874 miRanda;mirMAP -0.203055086076647 3.24191022832598e-07 NA NA NA hsa-miR-590-5p ITGB1 1.22823897140696 7.5538778278798e-17 -0.32912884903585 0.00358090194706874 miRanda -0.216094998651334 5.8408649771119e-09 NA NA NA hsa-miR-616-5p ITGB1 2.3596511369846 3.26881700557061e-22 -0.32912884903585 0.00358090194706874 mirMAP -0.114282921052809 5.7359746858762e-07 NA NA NA hsa-miR-7-1-3p ITGB1 1.23074353429962 9.62692371802457e-18 -0.32912884903585 0.00358090194706874 MirTarget;mirMAP -0.227464753706686 2.11327343485183e-09 NA NA NA hsa-miR-769-5p ITGB1 0.928214895090365 4.19801106060332e-11 -0.32912884903585 0.00358090194706874 miRNAWalker2_validate -0.239725267502206 1.25795972726759e-09 NA NA NA hsa-let-7d-5p ITGB3 0.0470413504723624 0.6502410569426 -1.50192563519069 9.02022897096921e-09 MirTarget -0.946534862296191 2.63782692818951e-13 NA NA NA hsa-let-7g-5p ITGB3 0.0868874053614963 0.322163222422263 -1.50192563519069 9.02022897096921e-09 MirTarget;miRNATAP -0.68576960319706 1.34100661863927e-05 NA NA NA hsa-miR-185-5p ITGB3 0.0188696639275925 0.858581663208548 -1.50192563519069 9.02022897096921e-09 MirTarget -0.653595623259073 4.09942364683941e-07 NA NA NA hsa-miR-186-5p ITGB3 0.439819047090102 6.33375570167175e-05 -1.50192563519069 9.02022897096921e-09 mirMAP -0.47776256635257 0.000112330470824479 NA NA NA hsa-miR-18a-3p ITGB3 2.05585109851169 1.40576069637563e-20 -1.50192563519069 9.02022897096921e-09 miRNATAP -0.373067681295585 8.15628424351029e-11 NA NA NA hsa-miR-204-5p ITGB3 -0.0810285934586013 0.843532626523268 -1.50192563519069 9.02022897096921e-09 miRNAWalker2_validate -0.145743289082189 1.46005801476638e-05 NA NA NA hsa-miR-221-3p ITGB3 -0.38281209626394 0.00382602010056484 -1.50192563519069 9.02022897096921e-09 MirTarget -0.248645825164852 0.0162039712599635 NA NA NA hsa-miR-222-3p ITGB3 0.650386170149202 1.83345699702669e-06 -1.50192563519069 9.02022897096921e-09 MirTarget -0.582730024026021 2.24871423856147e-09 NA NA NA hsa-miR-28-5p ITGB3 0.189534080376749 0.0278108067630943 -1.50192563519069 9.02022897096921e-09 miRanda -0.797443393363866 5.80412838467706e-07 NA NA NA hsa-miR-30b-5p ITGB3 -1.50117013761001 1.78247435398346e-20 -1.50192563519069 9.02022897096921e-09 mirMAP -0.19005379393151 0.0177329708163569 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30c-5p ITGB3 -0.426804145561029 0.00403132854321475 -1.50192563519069 9.02022897096921e-09 miRNAWalker2_validate;mirMAP;miRNATAP -0.304596940214011 0.000897158349710475 NA NA NA hsa-miR-320a ITGB3 0.25030125889857 0.0695425511666725 -1.50192563519069 9.02022897096921e-09 miRanda -0.295867923527738 0.00288731946826635 NA NA NA hsa-miR-320b ITGB3 1.16387990475466 1.33051259463572e-10 -1.50192563519069 9.02022897096921e-09 miRanda -0.199114146793218 0.00675506570108347 NA NA NA hsa-miR-3607-3p ITGB3 0.797258097957342 0.000266170796527225 -1.50192563519069 9.02022897096921e-09 MirTarget;mirMAP;miRNATAP -0.259915036084798 2.37541120475453e-05 NA NA NA hsa-miR-425-5p ITGB3 0.85235119766839 8.55415485589217e-07 -1.50192563519069 9.02022897096921e-09 MirTarget -0.481672309040411 2.5481276599012e-10 NA NA NA hsa-miR-429 ITGB3 1.44127712764248 1.7824212712414e-11 -1.50192563519069 9.02022897096921e-09 miRanda -0.502839274943724 2.34949247456985e-17 NA NA NA hsa-miR-589-5p ITGB3 0.339024922203657 0.00325638073358222 -1.50192563519069 9.02022897096921e-09 MirTarget -0.493927393370416 2.96314415480594e-05 NA NA NA hsa-miR-590-3p ITGB3 0.9225805269779 6.0121446263776e-11 -1.50192563519069 9.02022897096921e-09 PITA;miRanda -0.645409882768946 2.68105824527533e-12 NA NA NA hsa-miR-590-5p ITGB3 1.22823897140696 7.5538778278798e-17 -1.50192563519069 9.02022897096921e-09 miRanda -0.635916564277881 1.76150645224801e-13 NA NA NA hsa-miR-616-3p ITGB3 1.84210973859322 4.49541996670696e-19 -1.50192563519069 9.02022897096921e-09 mirMAP -0.277972929651619 3.27947449426572e-05 NA NA NA hsa-miR-98-5p ITGB3 0.278359437335009 0.00921227131925612 -1.50192563519069 9.02022897096921e-09 miRNAWalker2_validate;MirTarget -0.563964626024567 1.0134287816984e-05 26445551 miR 98 targets ITGB3 to inhibit proliferation migration and invasion of non small cell lung cancer; Furthermore we identified that miR-98 exerted inhibitory roles by directly binding to 3'-UTR of ITGB3 mRNA thus negatively regulated the expression of ITGB3; Interestingly upon restoring the expression of ITGB3 the effect of miR-98 on cell proliferation was partially reversed; Our findings suggest that miR-98 prevents proliferation migration and invasion of lung cancer cells by directly binding to the 3'-UTR of ITGB3 mRNA and could be a promising treatment option in anticancer therapy lung squamous cell cancer hsa-miR-16-5p ITGB4 0.200674510503047 0.0593717079356147 2.85437797701122 1.73392286179354e-39 miRNAWalker2_validate -0.345934028701444 0.00323578480840592 NA NA NA hsa-miR-30a-5p ITGB4 -2.98793938555326 1.93840183838367e-49 2.85437797701122 1.73392286179354e-39 miRNAWalker2_validate -0.459409345063828 2.02711726448699e-19 NA NA NA hsa-miR-335-5p ITGB4 -0.324086861750615 0.0899025346373434 2.85437797701122 1.73392286179354e-39 miRNAWalker2_validate -0.271452201824164 2.45634759385853e-05 NA NA NA hsa-miR-532-5p ITGB4 -0.485749465832866 0.000138169498131266 2.85437797701122 1.73392286179354e-39 miRNATAP -0.522321424875973 4.63922189037185e-08 NA NA NA hsa-miR-139-5p ITGB5 -2.25560964518719 9.95317711940085e-30 0.636072142975517 2.62052633429822e-06 miRanda -0.14889507084638 3.67579272615667e-06 NA NA NA hsa-miR-155-5p ITGB5 0.459859353454849 0.00515473360914761 0.636072142975517 2.62052633429822e-06 miRNAWalker2_validate -0.12349893995108 0.00369543817273959 NA NA NA hsa-miR-361-5p ITGB5 -0.0236974652105824 0.799888526193556 0.636072142975517 2.62052633429822e-06 miRanda -0.161491752224948 0.0347596899149012 NA NA NA hsa-miR-374a-3p ITGB5 -0.104091172625131 0.359725600505889 0.636072142975517 2.62052633429822e-06 MirTarget -0.129673101594729 0.037876573262158 NA NA NA hsa-miR-378a-5p ITGB5 0.258484592107758 0.0990592322994553 0.636072142975517 2.62052633429822e-06 MirTarget -0.13029040910725 0.00364088463655514 NA NA NA hsa-miR-484 ITGB5 0.290563207815661 0.0187067524486015 0.636072142975517 2.62052633429822e-06 miRNATAP -0.148751688793006 0.00911204579477036 NA NA NA hsa-miR-486-5p ITGB5 -3.31030668897609 1.04617579408648e-33 0.636072142975517 2.62052633429822e-06 miRanda -0.108890162354662 2.44311849017588e-06 NA NA NA hsa-miR-16-1-3p ITGB6 -0.156899711138322 0.214597270113743 -1.62193335101969 4.04956935293058e-08 mirMAP -0.248484652584594 0.0434585327848253 NA NA NA hsa-miR-17-5p ITGB6 1.27106228457264 5.91314767482551e-14 -1.62193335101969 4.04956935293058e-08 TargetScan -0.578583630704279 1.61651763405835e-11 NA NA NA hsa-miR-197-3p ITGB6 0.72925569501114 3.6335380891617e-08 -1.62193335101969 4.04956935293058e-08 MirTarget -0.516250633263388 5.8557877673463e-06 NA NA NA hsa-miR-203a-3p ITGB6 1.5633612920102 3.65621097298307e-07 -1.62193335101969 4.04956935293058e-08 MirTarget -0.21495185481429 1.08072274622348e-05 NA NA NA hsa-miR-205-5p ITGB6 7.4255450988826 2.64056553520099e-76 -1.62193335101969 4.04956935293058e-08 MirTarget -0.1544941560998 5.12886458733919e-07 NA NA NA hsa-miR-3065-5p ITGB6 -0.963317497666877 0.000100334146005009 -1.62193335101969 4.04956935293058e-08 mirMAP -0.125190938249668 0.0444019008943131 NA NA NA hsa-miR-33a-3p ITGB6 0.540032749009224 0.00270907254062352 -1.62193335101969 4.04956935293058e-08 mirMAP -0.372109655455484 1.39308206242649e-05 NA NA NA hsa-miR-3607-3p ITGB6 0.797258097957342 0.000266170796527225 -1.62193335101969 4.04956935293058e-08 mirMAP -0.255840625357187 0.000238549237379903 NA NA NA hsa-miR-450b-5p ITGB6 1.40607004112146 2.03869814951451e-15 -1.62193335101969 4.04956935293058e-08 MirTarget;mirMAP -0.227550103111027 0.00657826444968471 NA NA NA hsa-miR-590-3p ITGB6 0.9225805269779 6.0121446263776e-11 -1.62193335101969 4.04956935293058e-08 mirMAP -0.412388870359914 0.000108246572449672 NA NA NA hsa-miR-629-5p ITGB6 0.896078284709513 1.3248439450822e-08 -1.62193335101969 4.04956935293058e-08 MirTarget -0.414665895750018 1.36971283762677e-05 NA NA NA hsa-miR-7-1-3p ITGB6 1.23074353429962 9.62692371802457e-18 -1.62193335101969 4.04956935293058e-08 MirTarget -0.676059293770684 1.68199152942095e-11 NA NA NA hsa-miR-944 ITGB6 6.31318502943581 6.64615435406088e-56 -1.62193335101969 4.04956935293058e-08 mirMAP -0.224408014714557 2.72610425981466e-12 NA NA NA hsa-miR-107 ITGB7 -0.456345046928702 5.29231946717953e-06 -0.55443143305129 0.00186310043702809 miRanda -0.187743886287812 0.040660206295602 NA NA NA hsa-miR-125a-3p ITGB7 -0.490390905488357 0.00628500185334301 -0.55443143305129 0.00186310043702809 miRanda -0.105750775784109 0.0388093110967047 NA NA NA hsa-miR-320b ITGB7 1.16387990475466 1.33051259463572e-10 -0.55443143305129 0.00186310043702809 miRanda -0.122263812856809 0.0132829271786899 NA NA NA hsa-miR-339-5p ITGB7 0.695129802377533 1.42149990793285e-05 -0.55443143305129 0.00186310043702809 miRanda -0.348192937680254 3.65954178652683e-10 NA NA NA hsa-let-7a-5p ITGB8 -0.644221394537031 9.97672106245846e-14 2.26966747709261 5.64511394214336e-22 TargetScan -0.293646569223528 0.0438354535696773 NA NA NA hsa-miR-139-5p ITGB8 -2.25560964518719 9.95317711940085e-30 2.26966747709261 5.64511394214336e-22 PITA;miRanda;miRNATAP -0.404069392502913 2.32749805907714e-12 NA NA NA hsa-miR-142-5p ITGB8 -0.0363288420100352 0.821716201807163 2.26966747709261 5.64511394214336e-22 PITA -0.324539479971281 4.08904617064565e-05 NA NA NA hsa-miR-143-3p ITGB8 -1.50460346732144 5.17074613336112e-23 2.26966747709261 5.64511394214336e-22 MirTarget -0.352397602749631 7.14962787860761e-06 NA NA NA hsa-miR-145-5p ITGB8 -1.08109692150888 5.28948625689113e-14 2.26966747709261 5.64511394214336e-22 miRNAWalker2_validate;miRTarBase;MirTarget -0.247637018885204 0.00405963683612179 NA NA NA hsa-miR-181a-5p ITGB8 -1.31879909071317 2.04570351303734e-24 2.26966747709261 5.64511394214336e-22 miRNATAP -0.604897039214001 2.81306040729823e-11 NA NA NA hsa-miR-181b-5p ITGB8 -0.578702702808657 2.41220004393722e-05 2.26966747709261 5.64511394214336e-22 miRNATAP -0.471354605586363 2.70300494894008e-07 NA NA NA hsa-miR-181c-5p ITGB8 -1.36921360773694 5.61046203952059e-19 2.26966747709261 5.64511394214336e-22 miRNATAP -0.360541208529689 4.45914649647158e-06 NA NA NA hsa-miR-1976 ITGB8 -1.13975694972151 3.52774818586224e-19 2.26966747709261 5.64511394214336e-22 MirTarget -0.704360189250433 3.53649392337627e-14 NA NA NA hsa-miR-26a-5p ITGB8 -0.929312251092796 7.48452512025337e-23 2.26966747709261 5.64511394214336e-22 MirTarget -0.819617632351706 8.62010311216235e-11 NA NA NA hsa-miR-26b-5p ITGB8 -0.0183893267106221 0.882303333465809 2.26966747709261 5.64511394214336e-22 MirTarget -0.305178272842908 0.00326450347796215 NA NA NA hsa-miR-326 ITGB8 -2.468565451901 1.23182221778132e-19 2.26966747709261 5.64511394214336e-22 MirTarget;miRanda;miRNATAP -0.375279005884387 1.49541677876034e-18 NA NA NA hsa-miR-330-5p ITGB8 0.168243129357275 0.239196436552122 2.26966747709261 5.64511394214336e-22 MirTarget;miRanda;miRNATAP -0.331154379790113 0.000215673283357024 NA NA NA hsa-miR-335-5p ITGB8 -0.324086861750615 0.0899025346373434 2.26966747709261 5.64511394214336e-22 miRNAWalker2_validate -0.248564084273173 0.000190134396124911 NA NA NA hsa-miR-338-3p ITGB8 -2.39495045399875 3.50911311863594e-28 2.26966747709261 5.64511394214336e-22 miRanda -0.398070703211627 4.11442244918721e-14 NA NA NA hsa-miR-532-5p ITGB8 -0.485749465832866 0.000138169498131266 2.26966747709261 5.64511394214336e-22 PITA -0.264676046597037 0.00824707836593387 NA NA NA hsa-miR-106a-5p JAK1 0.887689359198128 2.74215376899957e-05 -0.807152255933132 2.71089849504403e-16 MirTarget -0.199341566112122 2.30311722667941e-17 NA NA NA hsa-miR-106b-5p JAK1 0.768146314773296 1.22330832259683e-08 -0.807152255933132 2.71089849504403e-16 miRNAWalker2_validate;MirTarget -0.304122409174969 1.56139782105702e-16 NA NA NA hsa-miR-128-3p JAK1 0.940275845868474 5.3111687457665e-10 -0.807152255933132 2.71089849504403e-16 miRNAWalker2_validate -0.208704390593071 3.39223280221099e-10 NA NA NA hsa-miR-15b-5p JAK1 0.575042920336974 9.75508983626876e-06 -0.807152255933132 2.71089849504403e-16 miRNAWalker2_validate -0.322608735788191 5.58533361995145e-17 NA NA NA hsa-miR-17-5p JAK1 1.27106228457264 5.91314767482551e-14 -0.807152255933132 2.71089849504403e-16 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.243560505587208 2.3605322666205e-17 NA NA NA hsa-miR-20a-5p JAK1 0.758237786270513 3.11867983980517e-05 -0.807152255933132 2.71089849504403e-16 MirTarget -0.178254257447236 1.76275282671841e-10 NA NA NA hsa-miR-20b-5p JAK1 0.396943783991848 0.194012869265072 -0.807152255933132 2.71089849504403e-16 MirTarget;miRNATAP -0.101903449128366 1.30615358580962e-09 NA NA NA hsa-miR-28-5p JAK1 0.189534080376749 0.0278108067630943 -0.807152255933132 2.71089849504403e-16 miRanda;miRNATAP -0.286176204746626 3.21405044817215e-06 NA NA NA hsa-miR-340-5p JAK1 0.172446891226333 0.176440862972852 -0.807152255933132 2.71089849504403e-16 MirTarget -0.126970326884072 0.00213708910630984 NA NA NA hsa-miR-421 JAK1 1.16807936195133 1.4164941985739e-11 -0.807152255933132 2.71089849504403e-16 miRanda -0.180069954950242 6.15505682452174e-10 NA NA NA hsa-miR-616-5p JAK1 2.3596511369846 3.26881700557061e-22 -0.807152255933132 2.71089849504403e-16 MirTarget -0.141265148997496 4.30441907965339e-12 NA NA NA hsa-miR-93-5p JAK1 1.27151657903037 1.96654008726155e-14 -0.807152255933132 2.71089849504403e-16 MirTarget;miRNATAP -0.261591906634668 2.2931545158768e-19 NA NA NA hsa-let-7a-3p JAK2 0.0442588630386531 0.71354010406076 -1.16714531138838 2.00040277205613e-15 mirMAP;miRNATAP -0.223239074619807 0.000625923329771147 NA NA NA hsa-miR-16-2-3p JAK2 0.505774348451832 0.00083906759991608 -1.16714531138838 2.00040277205613e-15 mirMAP -0.180402058952654 0.00043931124419102 NA NA NA hsa-miR-320b JAK2 1.16387990475466 1.33051259463572e-10 -1.16714531138838 2.00040277205613e-15 miRanda -0.162238685735723 0.000107471773788012 NA NA NA hsa-miR-337-3p JAK2 0.770753623579683 0.000321078619593811 -1.16714531138838 2.00040277205613e-15 PITA -0.177980449794084 6.64965624419638e-07 NA NA NA hsa-miR-590-3p JAK2 0.9225805269779 6.0121446263776e-11 -1.16714531138838 2.00040277205613e-15 PITA;miRanda;mirMAP -0.185902892607937 0.00059718242972399 NA NA NA hsa-miR-616-5p JAK2 2.3596511369846 3.26881700557061e-22 -1.16714531138838 2.00040277205613e-15 miRNATAP -0.179147297339293 5.16982375037503e-09 NA NA NA hsa-miR-7-1-3p JAK2 1.23074353429962 9.62692371802457e-18 -1.16714531138838 2.00040277205613e-15 mirMAP -0.258662224697041 5.43600179269484e-07 NA NA NA hsa-miR-185-3p JAK3 -0.00708838970417514 0.966551345765524 0.266728121619709 0.17683140730811 MirTarget -0.178493302558321 0.00288683891933808 NA NA NA hsa-miR-3065-5p JAK3 -0.963317497666877 0.000100334146005009 0.266728121619709 0.17683140730811 MirTarget;mirMAP -0.19751942635414 9.50051489395099e-07 NA NA NA hsa-miR-30b-3p JAK3 -0.976858856774298 4.89616633369313e-08 0.266728121619709 0.17683140730811 MirTarget -0.233355842236623 2.40181404138184e-05 NA NA NA hsa-miR-335-5p JAK3 -0.324086861750615 0.0899025346373434 0.266728121619709 0.17683140730811 miRNAWalker2_validate -0.113735160584068 0.0317642344286768 NA NA NA hsa-miR-339-5p JAK3 0.695129802377533 1.42149990793285e-05 0.266728121619709 0.17683140730811 miRanda -0.30182192252914 1.07714753179285e-06 NA NA NA hsa-miR-421 JAK3 1.16807936195133 1.4164941985739e-11 0.266728121619709 0.17683140730811 miRanda -0.13277732673176 0.020456015923989 NA NA NA hsa-miR-129-5p KDR 2.0409652261565 1.19491474689015e-07 -2.7485907999885 5.09945563755753e-41 miRanda -0.124972306425247 2.53990362099296e-05 NA NA NA hsa-miR-149-5p KDR 3.1548412914629 4.44598605668453e-31 -2.7485907999885 5.09945563755753e-41 miRNATAP -0.415007946317017 8.47177490337482e-30 NA NA NA hsa-miR-15a-5p KDR -0.24629041301676 0.0253630661893983 -2.7485907999885 5.09945563755753e-41 miRNATAP -0.263891035786404 0.0141626241611665 NA NA NA hsa-miR-15b-5p KDR 0.575042920336974 9.75508983626876e-06 -2.7485907999885 5.09945563755753e-41 miRNATAP -0.686184904729234 2.31353379128988e-15 NA NA NA hsa-miR-16-5p KDR 0.200674510503047 0.0593717079356147 -2.7485907999885 5.09945563755753e-41 miRTarBase;miRNATAP -0.391529811659413 0.000424681422253686 26934556 The expression levels of two target genes Myb and VEGFR2 were affected significantly by miR-16 while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration; Hyperglycemia can impact the clinical outcomes of CRC patients likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2 colorectal cancer hsa-miR-19b-1-5p KDR 0.550369246540305 0.000830309981399621 -2.7485907999885 5.09945563755753e-41 miRNAWalker2_validate -0.35159414010691 5.46102962185471e-07 NA NA NA hsa-miR-200b-3p KDR 1.24269422431788 9.2707509169586e-11 -2.7485907999885 5.09945563755753e-41 miRNAWalker2_validate;miRTarBase;TargetScan -0.44897753009313 6.43440853893062e-15 NA NA NA hsa-miR-200c-3p KDR 1.44830286955223 1.39903737828795e-22 -2.7485907999885 5.09945563755753e-41 miRNATAP -0.728123426279422 3.13737200320213e-25 24205206 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway; MiR-200c at the nexus of epithelial-mesenchymal transition EMT is predicted to target VEGFR2; The purpose of this study is to test the hypothesis that regulation of VEGFR2 pathway by miR-200c could modulate the radiosensitivity of cancer cells; Bioinformatic analysis luciferase reporter assays and biochemical assays were carried out to validate VEGFR2 as a direct target of miR-200c; We identified VEGFR2 as a novel target of miR-200c lung squamous cell cancer hsa-miR-369-3p KDR 1.01732933007745 5.62255655622001e-06 -2.7485907999885 5.09945563755753e-41 PITA;miRNATAP -0.164274598255129 0.00152770732685063 NA NA NA hsa-miR-424-5p KDR 1.50572404087407 4.24425395615445e-20 -2.7485907999885 5.09945563755753e-41 miRNATAP -0.485706912894135 1.78159573995122e-13 NA NA NA hsa-miR-429 KDR 1.44127712764248 1.7824212712414e-11 -2.7485907999885 5.09945563755753e-41 PITA;miRanda;miRNATAP -0.442011917223875 3.81188611273256e-18 NA NA NA hsa-miR-455-5p KDR -0.00576316954435274 0.972192681692013 -2.7485907999885 5.09945563755753e-41 PITA;miRanda;miRNATAP -0.152516035816045 0.0326068850509579 NA NA NA hsa-miR-590-3p KDR 0.9225805269779 6.0121446263776e-11 -2.7485907999885 5.09945563755753e-41 miRanda -0.516191680940788 9.43373332959351e-11 NA NA NA hsa-miR-590-5p KDR 1.22823897140696 7.5538778278798e-17 -2.7485907999885 5.09945563755753e-41 miRanda -0.610035094191553 1.08310481351105e-16 NA NA NA hsa-miR-664a-3p KDR 0.131764091487629 0.242680083678861 -2.7485907999885 5.09945563755753e-41 mirMAP -0.318524858514279 0.00242408223861233 NA NA NA hsa-let-7f-1-3p KIT 0.0152174523424196 0.909387255829372 -2.51387746349587 3.68074786009764e-13 mirMAP -0.387353400664586 0.00509227481326557 NA NA NA hsa-miR-128-3p KIT 0.940275845868474 5.3111687457665e-10 -2.51387746349587 3.68074786009764e-13 MirTarget -0.254170152069051 0.0322253314288934 NA NA NA hsa-miR-130b-3p KIT 2.60393336883065 1.5273795648739e-42 -2.51387746349587 3.68074786009764e-13 miRNATAP -0.546085025786267 6.5661145887546e-11 NA NA NA hsa-miR-193b-3p KIT 1.98352147870322 4.50184724470473e-22 -2.51387746349587 3.68074786009764e-13 MirTarget;miRNATAP -0.548049658989819 2.37056791466366e-11 NA NA NA hsa-miR-19a-3p KIT 1.29022522620563 7.13786738838458e-11 -2.51387746349587 3.68074786009764e-13 miRTarBase;miRNATAP -0.283680256015659 0.00161138553708049 NA NA NA hsa-miR-19b-3p KIT 0.786722036548617 1.29623163115342e-06 -2.51387746349587 3.68074786009764e-13 miRNATAP -0.311410727281418 0.00514839258454917 NA NA NA hsa-miR-205-5p KIT 7.4255450988826 2.64056553520099e-76 -2.51387746349587 3.68074786009764e-13 miRNATAP -0.316483054140207 2.8861775454373e-19 NA NA NA hsa-miR-20a-5p KIT 0.758237786270513 3.11867983980517e-05 -2.51387746349587 3.68074786009764e-13 miRTarBase -0.355264642856243 0.000346892817462999 NA NA NA hsa-miR-221-3p KIT -0.38281209626394 0.00382602010056484 -2.51387746349587 3.68074786009764e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.373703838886823 0.00700618651553541 NA NA NA hsa-miR-222-3p KIT 0.650386170149202 1.83345699702669e-06 -2.51387746349587 3.68074786009764e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.818181529823622 3.54698650345298e-10 NA NA NA hsa-miR-301a-3p KIT 1.23940945645189 2.05328421457283e-11 -2.51387746349587 3.68074786009764e-13 miRNATAP -0.273283828161625 0.004548869863739 NA NA NA hsa-miR-335-3p KIT 0.462639143507351 0.00828753288457869 -2.51387746349587 3.68074786009764e-13 mirMAP -0.219261998619427 0.0358964528462746 NA NA NA hsa-miR-421 KIT 1.16807936195133 1.4164941985739e-11 -2.51387746349587 3.68074786009764e-13 miRanda -0.378329731866585 0.000248466074079577 NA NA NA hsa-miR-429 KIT 1.44127712764248 1.7824212712414e-11 -2.51387746349587 3.68074786009764e-13 miRNATAP -0.18818585872146 0.023570820630888 NA NA NA hsa-miR-450b-5p KIT 1.40607004112146 2.03869814951451e-15 -2.51387746349587 3.68074786009764e-13 MirTarget -0.356256634536069 0.000325732266152257 NA NA NA hsa-miR-454-3p KIT 0.942883363058312 9.73843658862518e-10 -2.51387746349587 3.68074786009764e-13 miRNATAP -0.421389009208453 0.000277806691346456 NA NA NA hsa-miR-590-3p KIT 0.9225805269779 6.0121446263776e-11 -2.51387746349587 3.68074786009764e-13 miRanda;mirMAP -0.39573309183852 0.00183407083797573 NA NA NA hsa-miR-671-5p KIT 2.24826787094975 1.21091062273857e-36 -2.51387746349587 3.68074786009764e-13 MirTarget -0.750174617076603 5.25494984120231e-17 NA NA NA hsa-miR-17-3p KITLG -0.0552375132842826 0.669668193529718 -0.818823770310189 1.45744592001828e-06 MirTarget -0.224425380701549 0.00104443609076383 NA NA NA hsa-miR-186-5p KITLG 0.439819047090102 6.33375570167175e-05 -0.818823770310189 1.45744592001828e-06 mirMAP -0.174644166647129 0.0299032898651586 NA NA NA hsa-miR-188-5p KITLG 1.06898382373709 3.5483498326687e-08 -0.818823770310189 1.45744592001828e-06 MirTarget -0.182857527711295 3.94577372075851e-05 NA NA NA hsa-miR-19a-3p KITLG 1.29022522620563 7.13786738838458e-11 -0.818823770310189 1.45744592001828e-06 mirMAP -0.18178881103948 2.45012530108166e-05 NA NA NA hsa-miR-19b-3p KITLG 0.786722036548617 1.29623163115342e-06 -0.818823770310189 1.45744592001828e-06 mirMAP -0.239831524964712 6.42411167974338e-06 NA NA NA hsa-miR-30e-5p KITLG 0.186424244301373 0.077486249643257 -0.818823770310189 1.45744592001828e-06 mirMAP -0.227313411283644 0.00710608119878148 NA NA NA hsa-miR-320b KITLG 1.16387990475466 1.33051259463572e-10 -0.818823770310189 1.45744592001828e-06 MirTarget;PITA;miRanda -0.104258960498763 0.0283531219707218 NA NA NA hsa-miR-335-3p KITLG 0.462639143507351 0.00828753288457869 -0.818823770310189 1.45744592001828e-06 MirTarget -0.149635093789007 0.00285737136443915 NA NA NA hsa-miR-345-5p KITLG 2.15589176233429 1.27644715671951e-24 -0.818823770310189 1.45744592001828e-06 MirTarget -0.117538141405992 0.00267854925888661 NA NA NA hsa-miR-589-3p KITLG 1.64129600791754 3.03909323325799e-16 -0.818823770310189 1.45744592001828e-06 mirMAP -0.160986480972701 0.000129354201276467 NA NA NA hsa-miR-590-3p KITLG 0.9225805269779 6.0121446263776e-11 -0.818823770310189 1.45744592001828e-06 MirTarget;PITA;miRanda -0.159261561782332 0.0093404324270195 NA NA NA hsa-miR-7-1-3p KITLG 1.23074353429962 9.62692371802457e-18 -0.818823770310189 1.45744592001828e-06 mirMAP -0.20671328534791 0.000429628294232438 NA NA NA hsa-miR-9-5p KITLG 4.97757576742384 8.49748323724349e-41 -0.818823770310189 1.45744592001828e-06 MirTarget -0.116566469554729 2.08545746092646e-08 NA NA NA hsa-let-7a-5p KRAS -0.644221394537031 9.97672106245846e-14 0.551715093052378 4.58521279769817e-07 miRNAWalker2_validate;miRTarBase -0.192297707013347 0.00282781887378592 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-let-7b-3p KRAS -0.39527315467518 0.0023287663817318 0.551715093052378 4.58521279769817e-07 mirMAP;miRNATAP -0.148141246460172 0.000683984372258331 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;26581910;22584434;26516699;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS;Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA;Interestingly the differential expression of miRNA in mice also corroborated with the miRNA expression in human PC cell lines and tissue samples; ectopic expression of Let-7b in CD18/HPAF and Capan1 cells resulted in the downregulation of KRAS and MSST1 expression;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;;;; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;pancreatic cancer;lung squamous cell cancer hsa-miR-126-3p KRAS -1.52720963398862 2.32531989121959e-20 0.551715093052378 4.58521279769817e-07 miRNAWalker2_validate;miRTarBase -0.113455155913473 0.000478802374808575 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-126-5p KRAS -1.94634635849451 2.4038399235921e-37 0.551715093052378 4.58521279769817e-07 MirTarget -0.110497696998529 0.00100808744492767 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-140-3p KRAS -1.5688188604984 7.06409475976727e-33 0.551715093052378 4.58521279769817e-07 MirTarget -0.158578417051785 5.79223458862785e-05 NA NA NA hsa-miR-143-3p KRAS -1.50460346732144 5.17074613336112e-23 0.551715093052378 4.58521279769817e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.102321953686407 0.0035380552968487 22804917;27725862;19137007;26581910;23173124;26824186;21197560 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good PFS;The expression of miR-143 is often down-regulated and it might play an important role by targeting KRAS in colorectal cancer CRC; Dual-luciferase reporter assays were performed to validate whether KRAS was regulated by miR-143; Dual-luciferase assays indicated that KRAS was a direct target of miR-143 as subsequently demonstrated by qPCR and western blot analysis showing that infection of SW480 cells with Ad-ZD55-miR-143 resulted in the down-regulation of KRAS at both mRNA and protein levels;Role of miR 143 targeting KRAS in colorectal tumorigenesis; In particular among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs KRAS oncogene has been further experimentally validated as the target of miR-143; First an inverse correlation between KRAS protein and miR-143 in vivo was found; Second KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic whereas miR-143 inhibitor increased KRAS protein level; Third luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts; Finally inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2; Taken together the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation;MicroRNA 143 replenishment re sensitizes colorectal cancer cells harboring mutant but not wild type KRAS to paclitaxel treatment; Our results showed that miR-143 but not let-7b increased sensitization of KRAS mutant tumor cells to paclitaxel; Furthermore transfection of miR-143 but not let-7b mimic negatively regulated the expression of mutant but not wild-type KRAS; Combination of miR-143 mimic and paclitaxel induced the onset of apoptosis and reverted in vitro metastatic properties migration and invasion in KRAS mutant tumor cells; MiR-143 thus can be used as a chemosensitizer for the treatment of KRAS mutant tumors and warrants further investigations in in vitro and pre-clinical in vivo models;In turn the level of miR-143 in CRC cells decreasing the amount of MACC1 metastasis-associated in colon cancer-1 and oncogenic KRAS protein may be utilized as a prognostic marker;Stable miR-143 or miR-145 overexpression increased cell sensitivity to cetuximab resulting in a significant increase of cetuximab-mediated ADCC independently of KRAS status;miR 143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS; The expression level of miR-143 and its target gene KRAS were measured by realtime PCR and western blotting respectively; Our results revealed an inverse correlation of expression between miR-143 and KRAS protein in prostate cancer samples Pearson's correlation scatter plots: R = -0.707 P < 0.05; These findings suggest that miR-143 plays an important role in prostate cancer proliferation migration and chemosensitivity by suppressing KRAS and subsequent inactivation of MAPK pathway which provides a potential development of a new approach for the treatment of prostate cancer ;;tumorigenesis;;metastasis;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colon cancer;prostate cancer hsa-miR-181a-5p KRAS -1.31879909071317 2.04570351303734e-24 0.551715093052378 4.58521279769817e-07 miRNAWalker2_validate -0.15903410287655 0.000108435330848038 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-193a-5p KRAS -0.00304227718866112 0.979579483135477 0.551715093052378 4.58521279769817e-07 miRNATAP -0.167794120257635 0.00047584814897087 NA NA NA hsa-miR-195-3p KRAS -1.41416709285168 7.64629179830096e-19 0.551715093052378 4.58521279769817e-07 mirMAP -0.147095161665511 1.23280338746186e-05 NA NA NA hsa-miR-30a-3p KRAS -2.84775732421554 1.32356843902033e-38 0.551715093052378 4.58521279769817e-07 MirTarget;miRNATAP -0.117272847276918 3.33437287892724e-07 NA NA NA hsa-miR-30a-5p KRAS -2.98793938555326 1.93840183838367e-49 0.551715093052378 4.58521279769817e-07 mirMAP;miRNATAP -0.126638360891879 1.61078207571239e-07 NA NA NA hsa-miR-30d-5p KRAS -2.06908130936031 2.23574479943606e-47 0.551715093052378 4.58521279769817e-07 mirMAP;miRNATAP -0.109993868804609 0.00159863513641833 NA NA NA hsa-miR-30e-3p KRAS -0.568615785445122 1.6997540158547e-07 0.551715093052378 4.58521279769817e-07 MirTarget -0.197389466642083 0.000130346781129077 NA NA NA hsa-miR-181a-5p LAMA1 -1.31879909071317 2.04570351303734e-24 2.86264272756221 3.56664630282198e-10 MirTarget -0.618807966600678 0.000370939959421427 NA NA NA hsa-miR-181c-5p LAMA1 -1.36921360773694 5.61046203952059e-19 2.86264272756221 3.56664630282198e-10 MirTarget -0.630541815602802 1.9061189919872e-05 NA NA NA hsa-miR-342-3p LAMA1 0.34628335679908 0.0121498405984511 2.86264272756221 3.56664630282198e-10 miRanda -0.422128225536112 0.0152822480769959 NA NA NA hsa-miR-590-3p LAMA2 0.9225805269779 6.0121446263776e-11 -2.06012033400699 1.86325562450117e-16 miRanda -0.651713699641459 5.03269798131624e-13 NA NA NA hsa-miR-17-5p LAMA3 1.27106228457264 5.91314767482551e-14 -0.1535854238476 0.58373309961689 TargetScan -0.257099041970063 0.00166296870039659 NA NA NA hsa-miR-217 LAMA3 -0.501449190998853 0.0366805136279841 -0.1535854238476 0.58373309961689 PITA;miRanda -0.174357430606876 0.00338781911891141 NA NA NA hsa-miR-26b-5p LAMA3 -0.0183893267106221 0.882303333465809 -0.1535854238476 0.58373309961689 miRNAWalker2_validate -0.270111536218994 0.020494874581939 NA NA NA hsa-miR-590-3p LAMA3 0.9225805269779 6.0121446263776e-11 -0.1535854238476 0.58373309961689 miRanda -0.43030182040958 1.33521203464543e-05 NA NA NA hsa-miR-129-5p LAMA4 2.0409652261565 1.19491474689015e-07 -1.76922722939192 7.59584179131262e-21 MirTarget;miRanda -0.12415417791429 1.407890896753e-06 NA NA NA hsa-miR-188-5p LAMA4 1.06898382373709 3.5483498326687e-08 -1.76922722939192 7.59584179131262e-21 miRNATAP -0.414476703116778 8.92402936709583e-17 NA NA NA hsa-miR-429 LAMA4 1.44127712764248 1.7824212712414e-11 -1.76922722939192 7.59584179131262e-21 miRanda -0.401090507644247 9.39912901396955e-20 NA NA NA hsa-miR-590-3p LAMA4 0.9225805269779 6.0121446263776e-11 -1.76922722939192 7.59584179131262e-21 miRanda -0.57903021992745 1.71922946321807e-17 NA NA NA hsa-miR-590-5p LAMA4 1.22823897140696 7.5538778278798e-17 -1.76922722939192 7.59584179131262e-21 MirTarget;miRanda -0.636655936608442 2.77178182973085e-24 NA NA NA hsa-miR-93-3p LAMA4 1.87333981556813 3.67417899907584e-29 -1.76922722939192 7.59584179131262e-21 miRNAWalker2_validate -0.591313405895526 1.47380192561387e-29 NA NA NA hsa-miR-142-3p LAMB1 0.674575513897478 0.000112525767514321 0.0164950028453514 0.915130953289271 miRanda -0.138163058990181 0.00207476081495916 NA NA NA hsa-miR-16-5p LAMB1 0.200674510503047 0.0593717079356147 0.0164950028453514 0.915130953289271 miRNAWalker2_validate -0.442270262216056 1.92331077939189e-09 NA NA NA hsa-miR-339-5p LAMB1 0.695129802377533 1.42149990793285e-05 0.0164950028453514 0.915130953289271 miRanda -0.211995153158487 1.26744919213045e-05 NA NA NA hsa-miR-500a-3p LAMB1 0.0997410457813883 0.420760746886716 0.0164950028453514 0.915130953289271 miRNAWalker2_validate -0.141697454902176 0.0278878951549902 NA NA NA hsa-miR-196b-5p LAMB2 4.89546317785728 5.52340923778503e-45 -1.63555896215669 1.66094746365896e-32 miRNAWalker2_validate -0.186845001834421 2.12866908711375e-24 NA NA NA hsa-miR-29b-1-5p LAMB2 0.589580770665507 0.000377984052129227 -1.63555896215669 1.66094746365896e-32 MirTarget -0.121117417488438 0.00874306687071469 NA NA NA hsa-miR-484 LAMB2 0.290563207815661 0.0187067524486015 -1.63555896215669 1.66094746365896e-32 miRNAWalker2_validate -0.301585948858102 1.1178721292292e-06 NA NA NA hsa-miR-16-5p LAMB3 0.200674510503047 0.0593717079356147 1.3858813894068 6.75213749181517e-09 miRNAWalker2_validate -0.451897321352784 0.000129613714768259 NA NA NA hsa-miR-218-5p LAMB3 -1.79097768150997 1.46926601815429e-27 1.3858813894068 6.75213749181517e-09 miRNAWalker2_validate;miRTarBase -0.43570694772808 2.83682852199044e-10 25337271;20163849;23320911;23159910;17998940 The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma ESCC;Polymorphisms involved in the miR 218 LAMB3 pathway and susceptibility of cervical cancer a case control study in Chinese women; MicroRNA-218 miR-218 can target laminin-5 beta3 LAMB3 but suppressed by HPV-16 E6 protein;However this association was not observed for the miR-218 binding site SNP rs2566 on LAMB3;Furthermore we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that LAMB3 was directly regulated by miR-218;We also demonstrate that the epithelial cell-specific marker LAMB3 is a target of miR-218; We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218 worse prognosis;;;; esophageal cancer;cervical and endocervical cancer;cervical and endocervical cancer;head and neck cancer;cervical and endocervical cancer hsa-miR-362-3p LAMB3 -0.604045380242671 0.000132629619624125 1.3858813894068 6.75213749181517e-09 MirTarget;miRanda -0.392996076730906 4.72127315307894e-07 NA NA NA hsa-miR-484 LAMB3 0.290563207815661 0.0187067524486015 1.3858813894068 6.75213749181517e-09 MirTarget;miRNATAP -0.249724275035402 0.0140784160844452 NA NA NA hsa-miR-126-5p LAMC1 -1.94634635849451 2.4038399235921e-37 0.23945222245174 0.0543187878210666 mirMAP -0.186540370047427 5.9519231830151e-07 NA NA NA hsa-miR-139-5p LAMC1 -2.25560964518719 9.95317711940085e-30 0.23945222245174 0.0543187878210666 miRanda -0.127504708133998 1.30095655797347e-05 NA NA NA hsa-miR-140-5p LAMC1 -0.615965395622439 1.05820583250804e-08 0.23945222245174 0.0543187878210666 MirTarget;PITA;miRanda;miRNATAP -0.326202576574942 1.50338606367596e-08 NA NA NA hsa-miR-146b-5p LAMC1 -0.432155779449763 0.00591587599739451 0.23945222245174 0.0543187878210666 miRanda -0.186715368807118 3.24800918406674e-06 NA NA NA hsa-miR-15a-5p LAMC1 -0.24629041301676 0.0253630661893983 0.23945222245174 0.0543187878210666 MirTarget -0.28045406435318 1.14319523119039e-06 NA NA NA hsa-miR-16-5p LAMC1 0.200674510503047 0.0593717079356147 0.23945222245174 0.0543187878210666 miRNAWalker2_validate;MirTarget -0.259058141862766 1.5672652083311e-05 NA NA NA hsa-miR-186-5p LAMC1 0.439819047090102 6.33375570167175e-05 0.23945222245174 0.0543187878210666 mirMAP -0.188835470868532 0.00109152063032422 NA NA NA hsa-miR-195-5p LAMC1 -1.62452829530841 2.94084397454942e-29 0.23945222245174 0.0543187878210666 MirTarget -0.161689008020963 6.66061806428029e-05 NA NA NA hsa-miR-29a-3p LAMC1 -1.03082784302378 5.4721714495133e-16 0.23945222245174 0.0543187878210666 MirTarget;miRNATAP -0.207030014392173 1.5612744639286e-05 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29b-3p LAMC1 -0.0219237619606503 0.883966228726957 0.23945222245174 0.0543187878210666 MirTarget;miRNATAP -0.227122101326487 6.19004867312146e-08 NA NA NA hsa-miR-29c-3p LAMC1 -1.50225173284958 1.90087771871443e-16 0.23945222245174 0.0543187878210666 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.161438100352339 1.04963842570613e-06 NA NA NA hsa-miR-320a LAMC1 0.25030125889857 0.0695425511666725 0.23945222245174 0.0543187878210666 miRanda -0.15502033045492 0.000795635473780191 NA NA NA hsa-miR-338-3p LAMC1 -2.39495045399875 3.50911311863594e-28 0.23945222245174 0.0543187878210666 MirTarget;miRanda -0.120298735413415 7.48112334678927e-06 NA NA NA hsa-miR-362-3p LAMC1 -0.604045380242671 0.000132629619624125 0.23945222245174 0.0543187878210666 miRanda -0.191969194813767 1.40393371807132e-06 NA NA NA hsa-miR-374a-5p LAMC1 -0.371522195407694 3.64288279697975e-05 0.23945222245174 0.0543187878210666 mirMAP -0.244879432355555 0.000571633198110612 NA NA NA hsa-miR-374b-5p LAMC1 -0.490675710652087 1.35508117735881e-06 0.23945222245174 0.0543187878210666 mirMAP -0.197672516562018 0.00155902192546434 NA NA NA hsa-miR-497-5p LAMC1 -1.37093122385312 2.06413037457593e-23 0.23945222245174 0.0543187878210666 MirTarget;miRNATAP -0.125947452889437 0.00389520682435921 NA NA NA hsa-miR-590-3p LAMC1 0.9225805269779 6.0121446263776e-11 0.23945222245174 0.0543187878210666 PITA;miRanda;mirMAP -0.104722304763526 0.0179641130307782 NA NA NA hsa-miR-942-5p LAMC1 0.707804935292199 1.66243149466953e-05 0.23945222245174 0.0543187878210666 MirTarget -0.131215861753405 0.000605645183045403 NA NA NA hsa-miR-148b-3p LAMC2 0.0385421182152106 0.68086754032186 1.3458055090412 2.87161712145624e-06 miRNAWalker2_validate -1.00803798517531 2.05986935496492e-10 NA NA NA hsa-miR-3065-3p LAMC2 -2.06226461576987 1.18100208176622e-17 1.3458055090412 2.87161712145624e-06 miRNATAP -0.256587453986869 1.17806758887535e-05 NA NA NA hsa-miR-338-3p LAMC2 -2.39495045399875 3.50911311863594e-28 1.3458055090412 2.87161712145624e-06 miRanda -0.280871078760066 8.16957184667657e-06 NA NA NA hsa-miR-338-5p LAMC2 -2.99778534642888 2.74111905046628e-39 1.3458055090412 2.87161712145624e-06 mirMAP -0.26113583352722 7.80188794100431e-06 NA NA NA hsa-miR-342-3p LAMC2 0.34628335679908 0.0121498405984511 1.3458055090412 2.87161712145624e-06 miRanda -0.453104046938421 2.51395083510627e-05 NA NA NA hsa-miR-375 LAMC2 -2.57769028725587 1.42344309409034e-12 1.3458055090412 2.87161712145624e-06 miRanda -0.187117170679716 1.81259161596701e-06 NA NA NA hsa-miR-421 LAMC2 1.16807936195133 1.4164941985739e-11 1.3458055090412 2.87161712145624e-06 miRanda -0.341049181480058 4.85793496453068e-05 NA NA NA hsa-miR-590-3p LAMC2 0.9225805269779 6.0121446263776e-11 1.3458055090412 2.87161712145624e-06 miRanda;mirMAP -0.321497910501562 0.00188936253228268 NA NA NA hsa-miR-590-5p LAMC2 1.22823897140696 7.5538778278798e-17 1.3458055090412 2.87161712145624e-06 miRanda -0.202988854316008 0.0372995998864718 NA NA NA hsa-miR-660-5p LAMC2 -0.701465625095864 2.01633605692768e-06 1.3458055090412 2.87161712145624e-06 MirTarget -0.554870830106617 1.76098309081793e-08 NA NA NA hsa-miR-7-5p LAMC2 2.15398885914606 3.95055061525106e-16 1.3458055090412 2.87161712145624e-06 miRNAWalker2_validate -0.165091549805428 0.00439995328657211 NA NA NA hsa-miR-130b-3p LAMC3 2.60393336883065 1.5273795648739e-42 -2.27664854906883 8.3177022803932e-20 mirMAP -0.424673414283536 4.49960516520849e-12 NA NA NA hsa-miR-192-5p LAMC3 0.755837132896928 2.446089221206e-05 -2.27664854906883 8.3177022803932e-20 mirMAP -0.288667589988289 0.000100067927083464 NA NA NA hsa-miR-301a-3p LAMC3 1.23940945645189 2.05328421457283e-11 -2.27664854906883 8.3177022803932e-20 mirMAP -0.344182355109896 9.3665789121992e-07 NA NA NA hsa-miR-324-3p LAMC3 0.800800089592099 8.38346636525273e-07 -2.27664854906883 8.3177022803932e-20 mirMAP -0.208037066705256 0.0111597018075338 NA NA NA hsa-miR-425-5p LAMC3 0.85235119766839 8.55415485589217e-07 -2.27664854906883 8.3177022803932e-20 mirMAP -0.346962383316558 5.24998874439611e-06 NA NA NA hsa-miR-452-5p LAMC3 1.08242667876786 2.34127628858457e-06 -2.27664854906883 8.3177022803932e-20 mirMAP -0.164209254760107 0.00460123625827741 NA NA NA hsa-miR-505-5p LAMC3 1.28871267080216 1.00459615050289e-12 -2.27664854906883 8.3177022803932e-20 mirMAP -0.291618934010598 4.99442763085886e-05 NA NA NA hsa-miR-939-5p LAMC3 1.36997300674111 9.97643104288974e-13 -2.27664854906883 8.3177022803932e-20 mirMAP -0.28781911001571 6.05509815074366e-05 NA NA NA hsa-miR-188-5p LPAR1 1.06898382373709 3.5483498326687e-08 -0.256594878783294 0.196381299490471 MirTarget -0.113172847190422 0.0285261209773068 NA NA NA hsa-miR-200c-3p LPAR1 1.44830286955223 1.39903737828795e-22 -0.256594878783294 0.196381299490471 miRNAWalker2_validate;MirTarget;miRNATAP -0.128391325921564 0.0480692142644241 NA NA NA hsa-miR-20a-3p LPAR1 1.79890197957803 9.4283425564752e-24 -0.256594878783294 0.196381299490471 MirTarget -0.105851470145598 0.0475593696237267 NA NA NA hsa-miR-26b-5p LPAR1 -0.0183893267106221 0.882303333465809 -0.256594878783294 0.196381299490471 miRNATAP -0.280979086107609 0.000638434260742297 NA NA NA hsa-miR-361-5p LPAR1 -0.0236974652105824 0.799888526193556 -0.256594878783294 0.196381299490471 miRanda -0.280858075613013 0.0112011568806492 NA NA NA hsa-miR-421 LPAR1 1.16807936195133 1.4164941985739e-11 -0.256594878783294 0.196381299490471 miRanda -0.132455663254996 0.0214890187261583 NA NA NA hsa-miR-429 LPAR1 1.44127712764248 1.7824212712414e-11 -0.256594878783294 0.196381299490471 MirTarget;miRanda;miRNATAP -0.134905811486525 0.00337165853004949 NA NA NA hsa-miR-501-5p LPAR1 0.316742767698094 0.0632047358679198 -0.256594878783294 0.196381299490471 MirTarget;miRNATAP -0.298008392479702 4.43799871313795e-07 NA NA NA hsa-miR-576-5p LPAR1 0.993748428316612 2.24066125794743e-10 -0.256594878783294 0.196381299490471 mirMAP -0.219690495913242 0.000513466330924115 NA NA NA hsa-miR-582-5p LPAR1 -0.0134667168827214 0.939685711149187 -0.256594878783294 0.196381299490471 miRNATAP -0.178518142922962 0.00178447313595461 NA NA NA hsa-miR-143-3p LPAR2 -1.50460346732144 5.17074613336112e-23 1.3124752618329 5.06565803174985e-32 miRNATAP -0.262250989767168 2.39012768179892e-12 NA NA NA hsa-miR-125b-2-3p LPAR5 -0.634675298870971 0.00860460224977146 1.41645287180035 1.20590663454292e-12 MirTarget -0.182376225138618 2.30882335800242e-05 NA NA NA hsa-miR-186-5p LPAR5 0.439819047090102 6.33375570167175e-05 1.41645287180035 1.20590663454292e-12 MirTarget -0.20451009398991 0.0332735196572908 NA NA NA hsa-miR-30c-5p MAP2K1 -0.426804145561029 0.00403132854321475 0.218212778063048 0.00249885233729039 miRNAWalker2_validate -0.107701305116258 1.20668799244819e-05 NA NA NA hsa-let-7b-5p MAP2K2 -0.759197439090238 1.31014217546415e-10 0.450615438730653 1.89744742070638e-08 miRNAWalker2_validate -0.121730780109889 0.000413611194349426 NA NA NA hsa-miR-142-5p MAPK1 -0.0363288420100352 0.821716201807163 0.057080375954361 0.543843800500236 mirMAP -0.137307855103678 3.31841475893731e-06 NA NA NA hsa-miR-29b-2-5p MAPK1 -1.04734214410093 8.2886590108117e-14 0.057080375954361 0.543843800500236 mirMAP -0.105990536872225 0.00133493867028401 NA NA NA hsa-miR-29b-3p MAPK1 -0.0219237619606503 0.883966228726957 0.057080375954361 0.543843800500236 mirMAP -0.11012196793726 0.000562611896988883 NA NA NA hsa-miR-30c-5p MAPK1 -0.426804145561029 0.00403132854321475 0.057080375954361 0.543843800500236 mirMAP -0.106167711172168 0.000965443670732469 NA NA NA hsa-miR-30e-5p MAPK1 0.186424244301373 0.077486249643257 0.057080375954361 0.543843800500236 mirMAP -0.120439846563651 0.00863831375599483 NA NA NA hsa-miR-330-3p MAPK1 0.00879260240870505 0.951284239507664 0.057080375954361 0.543843800500236 PITA;miRNATAP -0.124115356120451 0.000194297985461638 NA NA NA hsa-miR-342-3p MAPK1 0.34628335679908 0.0121498405984511 0.057080375954361 0.543843800500236 miRanda;mirMAP -0.11741005905257 0.000703368603991302 NA NA NA hsa-miR-423-3p MAPK3 1.28110076242996 1.865415526013e-23 -0.829031123183506 1.42641761284924e-21 miRNAWalker2_validate -0.171062177158021 5.28329210130324e-07 NA NA NA hsa-let-7g-3p MCL1 0.994803580752051 2.60686235393095e-10 -0.942838769978465 9.55513836111378e-22 MirTarget;miRNATAP -0.115236350561037 0.000470350920957398 NA NA NA hsa-miR-103a-2-5p MCL1 1.89326161187553 3.13008877983253e-17 -0.942838769978465 9.55513836111378e-22 MirTarget -0.152459324117694 1.26096617584158e-11 NA NA NA hsa-miR-106a-5p MCL1 0.887689359198128 2.74215376899957e-05 -0.942838769978465 9.55513836111378e-22 MirTarget;miRNATAP -0.12925994094589 1.37130889742941e-07 23904379 MiR 106a targets Mcl 1 to suppress cisplatin resistance of ovarian cancer A2780 cells; Real-time PCR Western blotting and luciferase reporter assay were applied to explore whether Mcl-1 was a target of miR-106a; Furthermore miR-106a inhibited cell survival and cisplatin resistance through downregulating the expression of Mcl-1; Mcl-1 was a direct target of miR-106a; These results suggest that miR-106a may provide a novel mechanism for understanding cisplatin resistance in ovarian cancer by modulating Mcl-1 drug resistance;poor survival ovarian cancer hsa-miR-106b-5p MCL1 0.768146314773296 1.22330832259683e-08 -0.942838769978465 9.55513836111378e-22 MirTarget;miRNATAP -0.283410145331744 5.11606439124243e-14 NA NA NA hsa-miR-127-5p MCL1 1.27457784705143 1.05732927040709e-10 -0.942838769978465 9.55513836111378e-22 miRNATAP -0.129911900493514 5.62746987689061e-07 NA NA NA hsa-miR-148b-5p MCL1 1.36450535453179 3.94217334650158e-16 -0.942838769978465 9.55513836111378e-22 miRNAWalker2_validate -0.175175768316067 5.53074529809552e-09 NA NA NA hsa-miR-151a-3p MCL1 0.292162840926293 0.0110038890457677 -0.942838769978465 9.55513836111378e-22 miRNAWalker2_validate -0.261301136184613 1.18302446819175e-08 NA NA NA hsa-miR-16-5p MCL1 0.200674510503047 0.0593717079356147 -0.942838769978465 9.55513836111378e-22 miRNAWalker2_validate -0.17262127202841 0.000609781384189133 NA NA NA hsa-miR-17-5p MCL1 1.27106228457264 5.91314767482551e-14 -0.942838769978465 9.55513836111378e-22 MirTarget;TargetScan;miRNATAP -0.183197984261045 7.73110026018839e-10 NA NA NA hsa-miR-186-5p MCL1 0.439819047090102 6.33375570167175e-05 -0.942838769978465 9.55513836111378e-22 miRNAWalker2_validate;mirMAP -0.273195152230228 9.7405530786595e-09 NA NA NA hsa-miR-193b-3p MCL1 1.98352147870322 4.50184724470473e-22 -0.942838769978465 9.55513836111378e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109934123909309 5.57563054811505e-06 26526790;25034398;21893020 miR 193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL 1; The aim of this study was to investigate whether miR-193b mediated the resistance of breast cancer cells to doxorubicin by targeting myeloid cell leukemia-1 MCL-1; It demonstrated that miR-193b directly targeted MCL-1 3'-UTR 3'-Untranslated Regions; Further studies indicated that miR-193b sensitized MCF-7/DOXR cells to doxorubicin through a mechanism involving the downregulation of MCL-1;Expression of miR-193b and myeloid cell leukemia-1 Mcl-1 protein were assessed by Q-PCR in situ hybridization and western blot immunohistochemistry respectively; A luciferase reporter of Mcl-1 3'-UTR was used for validation as a target of miR-193b; Significant downregulation of miR-193b and a higher level of Mcl-1 were observed in HBV-positive HCC cells and tissues; The activity of Mcl-1 3'-UTR reporter was inhibited by co-transfection with miR-193b mimic;miR 193b Regulates Mcl 1 in Melanoma; Herein we demonstrate that miR-193b also down-regulates myeloid cell leukemia sequence 1 Mcl-1 in melanoma cells; In a survey of melanoma samples the level of Mcl-1 is inversely correlated with the level of miR-193b; Overexpression of miR-193b in melanoma cells represses Mcl-1 expression; Furthermore the effect of miR-193b on the expression of Mcl-1 seems to be mediated by direct interaction between miR-193b and seed and seedless pairing sequences in the 3' untranslated region of Mcl-1 mRNA; Thus this study provides evidence that miR-193b directly regulates Mcl-1 and that down-regulation of miR-193b in vivo could be an early event in melanoma progression drug resistance;;progression breast cancer;liver cancer;melanoma hsa-miR-320b MCL1 1.16387990475466 1.33051259463572e-10 -0.942838769978465 9.55513836111378e-22 MirTarget;miRanda;miRNATAP -0.110202216233873 0.000110270946290355 26753959 Down regulation of miR 320 associated with cancer progression and cell apoptosis via targeting Mcl 1 in cervical cancer; MiR-320 has been reported to be down-regulated in various types of cancer and bioinformatics prediction indicated that it may regulate the expression of Mcl-1; The aim of this study is to investigate the role of miR-320 and its target gene Mcl-1 in cervical cancer progression and to assess their clinical significance; miR-320 and Mcl-1 expressions in human cervical cancer tissues were investigated by qRT-PCR in situ hybridization and immunohistochemical staining respectively; MiR-320 expression is significantly down-regulated versus Mcl-1 expression is up-regulated in cervical cancer tissues compared with normal controls with a negative correlation between them; Luciferase assay showed that miR-320 negatively regulates Mcl-1 expression; In addition miR-320 induces apoptosis via down-regulation of Mcl-1 and activation of caspase-3 but inhibits cell proliferation migration invasion and tumorigenesis in cervical cancer cells; Our studies show that miR-320 expression is decreased in cervical cancer and its expression is negatively correlated with Mcl-1 expression in cervical cancer; In addition miR-320 inhibits cervical cancer progression by down-regulation of Mcl-1 progression;tumorigenesis cervical and endocervical cancer hsa-miR-335-3p MCL1 0.462639143507351 0.00828753288457869 -0.942838769978465 9.55513836111378e-22 mirMAP -0.175649326240405 3.57076686190508e-09 NA NA NA hsa-miR-361-5p MCL1 -0.0236974652105824 0.799888526193556 -0.942838769978465 9.55513836111378e-22 miRanda -0.214315488563176 0.000203066079242543 NA NA NA hsa-miR-455-3p MCL1 2.18142848948175 2.92546018153478e-26 -0.942838769978465 9.55513836111378e-22 MirTarget -0.137813357056201 5.73193706796262e-09 NA NA NA hsa-miR-589-3p MCL1 1.64129600791754 3.03909323325799e-16 -0.942838769978465 9.55513836111378e-22 MirTarget -0.167191110343749 1.79539343424518e-11 NA NA NA hsa-miR-760 MCL1 2.46800133673516 9.92808266371112e-19 -0.942838769978465 9.55513836111378e-22 MirTarget -0.131962559923616 2.49564224594172e-13 NA NA NA hsa-miR-93-5p MCL1 1.27151657903037 1.96654008726155e-14 -0.942838769978465 9.55513836111378e-22 MirTarget;miRNATAP -0.216959415264611 4.97485804679066e-13 NA NA NA hsa-miR-940 MCL1 1.91696621517233 1.3556247816872e-17 -0.942838769978465 9.55513836111378e-22 PITA;miRNATAP -0.187216610031881 6.35931726352553e-18 NA NA NA hsa-miR-942-5p MCL1 0.707804935292199 1.66243149466953e-05 -0.942838769978465 9.55513836111378e-22 MirTarget -0.17686118260454 2.13440954862305e-08 NA NA NA hsa-miR-944 MCL1 6.31318502943581 6.64615435406088e-56 -0.942838769978465 9.55513836111378e-22 PITA;mirMAP -0.101347388066439 6.53201133709939e-21 NA NA NA hsa-miR-130a-3p MET -0.124312418026753 0.382773698737926 0.123885202591137 0.460385145754766 miRNAWalker2_validate -0.119144795888605 0.0495375303064287 NA NA NA hsa-miR-340-5p MET 0.172446891226333 0.176440862972852 0.123885202591137 0.460385145754766 miRNAWalker2_validate;miRTarBase -0.284864221588305 2.25128592917366e-05 24448820;21692045 It was of note that the colorectal cancer group with low miR-340 and high c-Met expression had the worst prognosis;miR 340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c Met; Ex vivo loss of miR-340 expression was associated with lymph node metastasis high tumor histological grade clinical stage and shorter overall survival of breast cancer as well as increased c-Met expression in breast cancer tissue specimens worse prognosis;cell migration;staging;metastasis;poor survival colorectal cancer;breast cancer hsa-miR-374a-5p MET -0.371522195407694 3.64288279697975e-05 0.123885202591137 0.460385145754766 mirMAP -0.265343427631811 0.00574339949880436 NA NA NA hsa-miR-127-3p MTCP1 0.195365550584373 0.313341095819209 0.404376150781539 0.00103086736363845 PITA;miRanda -0.102802742463658 0.00163616587769225 NA NA NA hsa-miR-140-5p MTOR -0.615965395622439 1.05820583250804e-08 0.340579552723318 0.000260427631888754 miRanda -0.140296492677295 0.00142607919408981 NA NA NA hsa-miR-16-5p MTOR 0.200674510503047 0.0593717079356147 0.340579552723318 0.000260427631888754 miRNAWalker2_validate -0.106935637424358 0.0188418110087993 NA NA NA hsa-miR-127-3p MYB 0.195365550584373 0.313341095819209 0.486976489878696 0.116343050006339 miRanda -0.228349161241603 0.00537588695501896 NA NA NA hsa-miR-139-5p MYB -2.25560964518719 9.95317711940085e-30 0.486976489878696 0.116343050006339 miRanda -0.179717006122326 0.0146586015749667 NA NA NA hsa-miR-193b-3p MYB 1.98352147870322 4.50184724470473e-22 0.486976489878696 0.116343050006339 miRNAWalker2_validate -0.234958377180437 0.00124284630458897 NA NA NA hsa-miR-338-3p MYB -2.39495045399875 3.50911311863594e-28 0.486976489878696 0.116343050006339 miRanda -0.182404041246366 0.00697414139509232 NA NA NA hsa-miR-455-5p MYB -0.00576316954435274 0.972192681692013 0.486976489878696 0.116343050006339 miRanda -0.225387422635984 0.0195507660240422 NA NA NA hsa-let-7a-5p MYC -0.644221394537031 9.97672106245846e-14 0.695061399462387 8.89619221714172e-05 miRNAWalker2_validate;miRTarBase -0.296716929620263 0.00433542118144502 23365639;20033209;17942906 We elected to validate our model in vitro by testing the effects of EGFR inhibition on downstream MYC miR-9 and let-7a expression; Our mathematical model explains the signaling link among EGFR MYC and miR-9 but not let-7;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;MicroRNA let 7a down regulates MYC and reverts MYC induced growth in Burkitt lymphoma cells; Regulation of MYC mRNA by let-7a was confirmed by transfections with pre-let-7a; Overexpression of let-7a 190% decreased Myc mRNA 70% and protein 75%; Inverse coordinate regulation of let-7a and mir-17-5p versus Myc mRNA by 10058-F4 pre-let-7a or siRNA MYC suggested that both miRNAs are Myc-regulated; These findings with let-7a add to the complexity of MYC regulation and suggest that dysregulation of these miRNAs participates in the genesis and maintenance of the lymphoma phenotype in Burkitt lymphoma cells and other MYC-dysregulated cancers ;; lung cancer;lung cancer;lymphoma hsa-let-7b-5p MYC -0.759197439090238 1.31014217546415e-10 0.695061399462387 8.89619221714172e-05 miRNAWalker2_validate -0.16309888881216 0.0324929119781912 23365639;20033209 Our mathematical model explains the signaling link among EGFR MYC and miR-9 but not let-7;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer ; lung cancer;lung cancer hsa-let-7c-5p MYC -1.09524404011671 7.33221488714214e-09 0.695061399462387 8.89619221714172e-05 miRNAWalker2_validate;miRTarBase -0.204742064483656 1.32970617473054e-05 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-26a-5p MYC -0.929312251092796 7.48452512025337e-23 0.695061399462387 8.89619221714172e-05 miRNAWalker2_validate -0.458257797642868 5.37972583944899e-07 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-374a-5p MYC -0.371522195407694 3.64288279697975e-05 0.695061399462387 8.89619221714172e-05 mirMAP -0.286555741887203 0.00519232423753003 NA NA NA hsa-miR-340-5p NFKB1 0.172446891226333 0.176440862972852 -0.494036648432299 6.49470002674157e-06 miRNATAP -0.164666176316527 0.000213832273182524 NA NA NA hsa-miR-590-3p NFKB1 0.9225805269779 6.0121446263776e-11 -0.494036648432299 6.49470002674157e-06 miRanda;mirMAP -0.112409991132448 0.00422264583893226 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung squamous cell cancer hsa-miR-92a-3p NFKB1 0.779792182638042 4.45572871602003e-09 -0.494036648432299 6.49470002674157e-06 miRNAWalker2_validate -0.163482767074276 8.81578439565361e-05 NA NA NA hsa-miR-320a NGF 0.25030125889857 0.0695425511666725 -0.179270319620975 0.594607149719592 miRanda -0.247789836536527 0.0487951439900347 NA NA NA hsa-miR-139-5p NGFR -2.25560964518719 9.95317711940085e-30 1.61385344011959 8.16135390581058e-06 miRanda -0.430988058586386 5.08782645884954e-07 NA NA NA hsa-miR-30b-3p NGFR -0.976858856774298 4.89616633369313e-08 1.61385344011959 8.16135390581058e-06 mirMAP -0.365965298019624 0.000373147244212133 NA NA NA hsa-miR-326 NGFR -2.468565451901 1.23182221778132e-19 1.61385344011959 8.16135390581058e-06 miRanda;mirMAP -0.156324133793044 0.0171392082765345 NA NA NA hsa-miR-34a-5p NGFR -0.43794334019748 0.000117590706048968 1.61385344011959 8.16135390581058e-06 mirMAP -0.360775130402792 0.029080721758731 NA NA NA hsa-miR-361-3p NGFR -0.491157107537441 1.38504517485595e-06 1.61385344011959 8.16135390581058e-06 mirMAP -0.375181082681638 0.0419391074191747 NA NA NA hsa-miR-429 NOS3 1.44127712764248 1.7824212712414e-11 -1.31311623078421 7.00277787734936e-12 miRanda -0.255252669232496 1.40123135467361e-08 NA NA NA hsa-miR-196a-5p NR4A1 4.72181712428645 1.62950855247633e-24 -2.81673149588708 6.28544914064385e-29 miRNAWalker2_validate -0.161157270944 6.56818285173846e-09 NA NA NA hsa-miR-324-5p NR4A1 1.21634042749489 1.07503319022833e-13 -2.81673149588708 6.28544914064385e-29 miRanda -0.357474918618436 1.31082487230672e-05 NA NA NA hsa-miR-93-5p NR4A1 1.27151657903037 1.96654008726155e-14 -2.81673149588708 6.28544914064385e-29 miRNAWalker2_validate -0.426955368261844 9.86499311837727e-08 NA NA NA hsa-let-7d-5p NRAS 0.0470413504723624 0.6502410569426 0.293105239103459 0.0032422748144533 MirTarget;miRNATAP -0.105292645402619 0.0349864978776135 NA NA NA hsa-let-7g-5p NRAS 0.0868874053614963 0.322163222422263 0.293105239103459 0.0032422748144533 MirTarget;miRNATAP -0.121969670671835 0.040117334068394 NA NA NA hsa-miR-26a-5p NRAS -0.929312251092796 7.48452512025337e-23 0.293105239103459 0.0032422748144533 mirMAP;miRNATAP -0.150072792062107 0.00356801448876457 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-27b-3p NRAS 0.0774984459252845 0.455541249499373 0.293105239103459 0.0032422748144533 miRNATAP -0.109977499392172 0.0273921275937727 NA NA NA hsa-miR-29c-3p NRAS -1.50225173284958 1.90087771871443e-16 0.293105239103459 0.0032422748144533 miRNATAP -0.103903695456019 9.68027766167335e-05 NA NA NA hsa-miR-374a-5p NRAS -0.371522195407694 3.64288279697975e-05 0.293105239103459 0.0032422748144533 mirMAP -0.116701988657932 0.0415538014500381 NA NA NA hsa-miR-374b-5p NRAS -0.490675710652087 1.35508117735881e-06 0.293105239103459 0.0032422748144533 mirMAP -0.162890888080673 0.0011382719437066 NA NA NA hsa-miR-664a-3p NRAS 0.131764091487629 0.242680083678861 0.293105239103459 0.0032422748144533 MirTarget -0.113353752585507 0.013176092167641 NA NA NA hsa-miR-221-3p NTF3 -0.38281209626394 0.00382602010056484 0.187799985598923 0.566791217830959 miRNATAP -0.307240808544693 0.0155938355920352 NA NA NA hsa-miR-222-3p NTF3 0.650386170149202 1.83345699702669e-06 0.187799985598923 0.566791217830959 miRNATAP -0.298037165339369 0.0146561376574871 NA NA NA hsa-miR-338-5p NTF3 -2.99778534642888 2.74111905046628e-39 0.187799985598923 0.566791217830959 PITA;miRNATAP -0.144444858370836 0.029436850904908 NA NA NA hsa-miR-374b-5p NTF3 -0.490675710652087 1.35508117735881e-06 0.187799985598923 0.566791217830959 mirMAP;miRNATAP -0.350412027109119 0.0340092910692707 NA NA NA hsa-miR-185-3p NTRK1 -0.00708838970417514 0.966551345765524 -1.30769767025382 8.63675240253747e-09 MirTarget -0.160215094544843 0.0231301796994372 NA NA NA hsa-miR-188-3p NTRK1 0.964670976618067 1.62224093573704e-05 -1.30769767025382 8.63675240253747e-09 PITA -0.178326654767539 0.00117266616772576 NA NA NA hsa-miR-125a-3p NTRK2 -0.490390905488357 0.00628500185334301 2.2569513655649 1.85621887091362e-05 miRanda -0.612554420240295 5.11390622166421e-05 NA NA NA hsa-miR-126-5p NTRK2 -1.94634635849451 2.4038399235921e-37 2.2569513655649 1.85621887091362e-05 mirMAP -0.415989083078365 0.010322294624314 NA NA NA hsa-miR-146b-5p NTRK2 -0.432155779449763 0.00591587599739451 2.2569513655649 1.85621887091362e-05 PITA;miRanda -0.535905832065384 0.00200101722216275 NA NA NA hsa-miR-181a-5p NTRK2 -1.31879909071317 2.04570351303734e-24 2.2569513655649 1.85621887091362e-05 mirMAP -1.24838474008496 1.33962385373511e-10 NA NA NA hsa-miR-181b-5p NTRK2 -0.578702702808657 2.41220004393722e-05 2.2569513655649 1.85621887091362e-05 mirMAP -1.45248519190134 3.57789534062107e-14 NA NA NA hsa-miR-181c-5p NTRK2 -1.36921360773694 5.61046203952059e-19 2.2569513655649 1.85621887091362e-05 mirMAP -0.471361620964339 0.00533606588143548 NA NA NA hsa-miR-30a-3p NTRK2 -2.84775732421554 1.32356843902033e-38 2.2569513655649 1.85621887091362e-05 mirMAP -0.369662858639692 0.000934978596621268 NA NA NA hsa-miR-30a-5p NTRK2 -2.98793938555326 1.93840183838367e-49 2.2569513655649 1.85621887091362e-05 mirMAP -0.429069757915824 0.000257866311633616 NA NA NA hsa-miR-30d-5p NTRK2 -2.06908130936031 2.23574479943606e-47 2.2569513655649 1.85621887091362e-05 mirMAP -0.401613205748448 0.0169603217672475 NA NA NA hsa-miR-30e-3p NTRK2 -0.568615785445122 1.6997540158547e-07 2.2569513655649 1.85621887091362e-05 mirMAP -0.51920355692727 0.0378363556891448 NA NA NA hsa-miR-326 NTRK2 -2.468565451901 1.23182221778132e-19 2.2569513655649 1.85621887091362e-05 miRanda -0.463437623532786 8.95389794608009e-07 NA NA NA hsa-miR-330-5p NTRK2 0.168243129357275 0.239196436552122 2.2569513655649 1.85621887091362e-05 miRanda -0.789106139641496 3.47720985075082e-05 NA NA NA hsa-miR-338-3p NTRK2 -2.39495045399875 3.50911311863594e-28 2.2569513655649 1.85621887091362e-05 miRanda -0.498445836805468 1.53481561347997e-05 NA NA NA hsa-miR-17-5p OSM 1.27106228457264 5.91314767482551e-14 -0.830513692932814 0.00065198335433284 TargetScan -0.336932842856567 2.07008119277031e-06 NA NA NA hsa-miR-185-3p OSM -0.00708838970417514 0.966551345765524 -0.830513692932814 0.00065198335433284 MirTarget -0.165982633023769 0.0260836466165661 NA NA NA hsa-miR-320b OSM 1.16387990475466 1.33051259463572e-10 -0.830513692932814 0.00065198335433284 miRanda -0.1743889664544 0.00990142666872507 NA NA NA hsa-miR-590-5p OSM 1.22823897140696 7.5538778278798e-17 -0.830513692932814 0.00065198335433284 miRanda -0.377166121733135 3.28726877816313e-06 NA NA NA hsa-let-7d-5p OSMR 0.0470413504723624 0.6502410569426 -0.0011134756042388 0.995237608252662 miRNATAP -0.229109787577975 0.0139984446890287 NA NA NA hsa-let-7g-5p OSMR 0.0868874053614963 0.322163222422263 -0.0011134756042388 0.995237608252662 miRNATAP -0.501005863653305 5.10473598900032e-06 NA NA NA hsa-miR-140-5p OSMR -0.615965395622439 1.05820583250804e-08 -0.0011134756042388 0.995237608252662 miRanda -0.211415394492361 0.0160607141706625 NA NA NA hsa-miR-200b-3p OSMR 1.24269422431788 9.2707509169586e-11 -0.0011134756042388 0.995237608252662 TargetScan -0.134517070145501 0.00546681065944703 NA NA NA hsa-miR-335-5p OSMR -0.324086861750615 0.0899025346373434 -0.0011134756042388 0.995237608252662 miRNAWalker2_validate -0.170303546581876 0.000615597392783106 NA NA NA hsa-miR-362-3p OSMR -0.604045380242671 0.000132629619624125 -0.0011134756042388 0.995237608252662 miRanda -0.163758507376075 0.00655072235817116 NA NA NA hsa-miR-374a-5p OSMR -0.371522195407694 3.64288279697975e-05 -0.0011134756042388 0.995237608252662 mirMAP -0.514668220129182 1.11018838206114e-06 NA NA NA hsa-miR-374b-5p OSMR -0.490675710652087 1.35508117735881e-06 -0.0011134756042388 0.995237608252662 mirMAP -0.311704572870686 0.000860458561049543 NA NA NA hsa-miR-590-3p OSMR 0.9225805269779 6.0121446263776e-11 -0.0011134756042388 0.995237608252662 miRanda;mirMAP;miRNATAP -0.196337760689925 0.00299698893042314 NA NA NA hsa-miR-199a-5p PCK1 0.125189495212204 0.398433974759894 -0.583496464364909 0.154014099577943 miRanda -0.29711374123497 0.0368675861577374 NA NA NA hsa-let-7d-5p PDGFA 0.0470413504723624 0.6502410569426 -0.566493290685757 0.00617719364060251 miRNAWalker2_validate -0.305328877954314 0.00325335021296586 NA NA NA hsa-miR-331-5p PDGFA 0.782866941570431 7.91287242315309e-09 -0.566493290685757 0.00617719364060251 PITA;miRNATAP -0.208421493074205 0.00689277513864611 NA NA NA hsa-miR-335-3p PDGFA 0.462639143507351 0.00828753288457869 -0.566493290685757 0.00617719364060251 mirMAP -0.211039341418645 0.000468541288104197 NA NA NA hsa-miR-421 PDGFA 1.16807936195133 1.4164941985739e-11 -0.566493290685757 0.00617719364060251 miRanda -0.379886490927969 1.05852380721189e-10 NA NA NA hsa-miR-484 PDGFA 0.290563207815661 0.0187067524486015 -0.566493290685757 0.00617719364060251 PITA;miRNATAP -0.413251384238311 1.35188065973319e-06 NA NA NA hsa-miR-548v PDGFA 1.38314663277825 1.32637772795382e-09 -0.566493290685757 0.00617719364060251 miRNATAP -0.213655175810651 1.10942514513366e-05 NA NA NA hsa-miR-576-5p PDGFA 0.993748428316612 2.24066125794743e-10 -0.566493290685757 0.00617719364060251 mirMAP -0.225030942072413 0.000670579419752717 NA NA NA hsa-miR-590-3p PDGFA 0.9225805269779 6.0121446263776e-11 -0.566493290685757 0.00617719364060251 miRanda -0.265656302022276 0.000303173940249158 NA NA NA hsa-miR-590-5p PDGFA 1.22823897140696 7.5538778278798e-17 -0.566493290685757 0.00617719364060251 miRanda -0.229549365652436 0.000897444540903574 NA NA NA hsa-let-7d-5p PDGFB 0.0470413504723624 0.6502410569426 -1.46363751201511 6.50553717124205e-17 miRNATAP -0.331404221580495 0.000277722601729492 NA NA NA hsa-let-7g-5p PDGFB 0.0868874053614963 0.322163222422263 -1.46363751201511 6.50553717124205e-17 miRNATAP -0.391307200020003 0.0003095964568377 NA NA NA hsa-miR-17-5p PDGFB 1.27106228457264 5.91314767482551e-14 -1.46363751201511 6.50553717124205e-17 TargetScan -0.37885710423999 2.93009118217232e-13 NA NA NA hsa-miR-18a-3p PDGFB 2.05585109851169 1.40576069637563e-20 -1.46363751201511 6.50553717124205e-17 MirTarget -0.271649583792517 4.42399998015487e-12 NA NA NA hsa-miR-342-3p PDGFB 0.34628335679908 0.0121498405984511 -1.46363751201511 6.50553717124205e-17 miRanda -0.258463441448513 0.000132875054600961 NA NA NA hsa-miR-421 PDGFB 1.16807936195133 1.4164941985739e-11 -1.46363751201511 6.50553717124205e-17 mirMAP -0.347757280713246 1.76944039831887e-11 NA NA NA hsa-miR-590-3p PDGFB 0.9225805269779 6.0121446263776e-11 -1.46363751201511 6.50553717124205e-17 PITA;miRanda;miRNATAP -0.401268008589259 2.96081297775767e-10 NA NA NA hsa-miR-940 PDGFB 1.91696621517233 1.3556247816872e-17 -1.46363751201511 6.50553717124205e-17 miRNATAP -0.249976481915505 1.52592742088161e-10 NA NA NA hsa-miR-16-2-3p PDGFC 0.505774348451832 0.00083906759991608 -0.38128598344344 0.0526343263122335 mirMAP -0.462283210621856 7.62753457504311e-13 NA NA NA hsa-miR-335-3p PDGFC 0.462639143507351 0.00828753288457869 -0.38128598344344 0.0526343263122335 mirMAP -0.171649037921055 0.00276283273483316 NA NA NA hsa-miR-340-5p PDGFC 0.172446891226333 0.176440862972852 -0.38128598344344 0.0526343263122335 mirMAP -0.22648074603748 0.00439539993086204 NA NA NA hsa-miR-421 PDGFC 1.16807936195133 1.4164941985739e-11 -0.38128598344344 0.0526343263122335 miRanda -0.245170954375363 1.50091981053954e-05 NA NA NA hsa-miR-590-3p PDGFC 0.9225805269779 6.0121446263776e-11 -0.38128598344344 0.0526343263122335 PITA;miRanda;mirMAP -0.255525985206839 0.000248223040803948 NA NA NA hsa-miR-616-5p PDGFC 2.3596511369846 3.26881700557061e-22 -0.38128598344344 0.0526343263122335 mirMAP -0.140598218818577 0.000455435537176213 NA NA NA hsa-miR-7-1-3p PDGFC 1.23074353429962 9.62692371802457e-18 -0.38128598344344 0.0526343263122335 mirMAP -0.287240979204853 1.73098936838752e-05 NA NA NA hsa-miR-7-5p PDGFC 2.15398885914606 3.95055061525106e-16 -0.38128598344344 0.0526343263122335 miRNAWalker2_validate -0.17701747685584 5.17842548205332e-06 NA NA NA hsa-miR-129-5p PDGFD 2.0409652261565 1.19491474689015e-07 -1.38718176022861 3.70230945803189e-08 miRanda -0.104114961906935 0.00182754957658368 NA NA NA hsa-miR-19b-1-5p PDGFD 0.550369246540305 0.000830309981399621 -1.38718176022861 3.70230945803189e-08 MirTarget -0.357091161041184 5.88951144624471e-06 NA NA NA hsa-miR-203a-3p PDGFD 1.5633612920102 3.65621097298307e-07 -1.38718176022861 3.70230945803189e-08 MirTarget -0.204014531756005 8.96728552438427e-07 NA NA NA hsa-miR-21-5p PDGFD 1.07034578283768 3.39448630342548e-28 -1.38718176022861 3.70230945803189e-08 miRNAWalker2_validate -0.461579913163011 0.000259858772555163 NA NA NA hsa-miR-320a PDGFD 0.25030125889857 0.0695425511666725 -1.38718176022861 3.70230945803189e-08 miRanda -0.2821087339736 0.00317178748117742 NA NA NA hsa-miR-320b PDGFD 1.16387990475466 1.33051259463572e-10 -1.38718176022861 3.70230945803189e-08 miRanda -0.230611369855465 0.00109163011354404 NA NA NA hsa-miR-331-5p PDGFD 0.782866941570431 7.91287242315309e-09 -1.38718176022861 3.70230945803189e-08 MirTarget -0.435534623100224 4.08324281015208e-06 NA NA NA hsa-miR-335-3p PDGFD 0.462639143507351 0.00828753288457869 -1.38718176022861 3.70230945803189e-08 mirMAP -0.222262904228395 0.00295866545460786 NA NA NA hsa-miR-450b-5p PDGFD 1.40607004112146 2.03869814951451e-15 -1.38718176022861 3.70230945803189e-08 mirMAP -0.21238302556402 0.00290853271362962 NA NA NA hsa-miR-590-3p PDGFD 0.9225805269779 6.0121446263776e-11 -1.38718176022861 3.70230945803189e-08 miRanda;mirMAP;miRNATAP -0.441771185778419 9.98360593814931e-07 NA NA NA hsa-miR-590-5p PDGFD 1.22823897140696 7.5538778278798e-17 -1.38718176022861 3.70230945803189e-08 miRanda -0.560884029209661 1.97561052972105e-11 NA NA NA hsa-miR-7-1-3p PDGFD 1.23074353429962 9.62692371802457e-18 -1.38718176022861 3.70230945803189e-08 mirMAP -0.42487605428208 9.97344857381224e-07 NA NA NA hsa-miR-9-5p PDGFD 4.97757576742384 8.49748323724349e-41 -1.38718176022861 3.70230945803189e-08 MirTarget -0.189878339728914 7.72935013224513e-10 NA NA NA hsa-miR-944 PDGFD 6.31318502943581 6.64615435406088e-56 -1.38718176022861 3.70230945803189e-08 MirTarget;mirMAP -0.229787029249252 1.53170887510002e-17 NA NA NA hsa-let-7a-3p PDGFRA 0.0442588630386531 0.71354010406076 -1.13905914639037 6.2506397545121e-07 mirMAP -0.243120806258243 0.0145719364920445 NA NA NA hsa-miR-106a-5p PDGFRA 0.887689359198128 2.74215376899957e-05 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.319179691594474 4.85347468666347e-09 NA NA NA hsa-miR-106b-5p PDGFRA 0.768146314773296 1.22330832259683e-08 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.774731000430855 5.05355364299936e-21 NA NA NA hsa-miR-129-5p PDGFRA 2.0409652261565 1.19491474689015e-07 -1.13905914639037 6.2506397545121e-07 miRanda;mirMAP;miRNATAP -0.105747269383571 0.000449236742068203 NA NA NA hsa-miR-130a-3p PDGFRA -0.124312418026753 0.382773698737926 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.288262575898934 0.000562381918419109 NA NA NA hsa-miR-130b-3p PDGFRA 2.60393336883065 1.5273795648739e-42 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.394708064508651 2.29847425676849e-13 NA NA NA hsa-miR-141-3p PDGFRA 1.96958415696982 1.4648441542521e-24 -1.13905914639037 6.2506397545121e-07 MirTarget -0.553858892202551 1.82315033396721e-24 NA NA NA hsa-miR-149-5p PDGFRA 3.1548412914629 4.44598605668453e-31 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.289388502655858 8.62242576878279e-14 NA NA NA hsa-miR-16-1-3p PDGFRA -0.156899711138322 0.214597270113743 -1.13905914639037 6.2506397545121e-07 MirTarget -0.257064137325554 0.00659047485337884 NA NA NA hsa-miR-17-5p PDGFRA 1.27106228457264 5.91314767482551e-14 -1.13905914639037 6.2506397545121e-07 MirTarget;TargetScan;miRNATAP -0.48679251897162 1.35570023582292e-13 NA NA NA hsa-miR-182-5p PDGFRA 2.16789823981744 5.64205069446407e-26 -1.13905914639037 6.2506397545121e-07 miRNATAP -0.395207172935924 3.26441079449631e-14 NA NA NA hsa-miR-186-5p PDGFRA 0.439819047090102 6.33375570167175e-05 -1.13905914639037 6.2506397545121e-07 MirTarget -0.453701566989445 2.39903353936678e-05 NA NA NA hsa-miR-196b-5p PDGFRA 4.89546317785728 5.52340923778503e-45 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.164762000404859 2.72975221369887e-08 NA NA NA hsa-miR-200a-3p PDGFRA 1.41385743755862 3.01641811769439e-11 -1.13905914639037 6.2506397545121e-07 MirTarget -0.388720960423401 1.52190072935709e-13 NA NA NA hsa-miR-20a-5p PDGFRA 0.758237786270513 3.11867983980517e-05 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.403183639627489 1.82721021122139e-10 NA NA NA hsa-miR-20b-5p PDGFRA 0.396943783991848 0.194012869265072 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.165012853141678 1.80528396991047e-05 NA NA NA hsa-miR-224-5p PDGFRA 2.66023106212545 6.37784852724057e-19 -1.13905914639037 6.2506397545121e-07 MirTarget -0.250868859158848 8.1276147334783e-12 NA NA NA hsa-miR-24-3p PDGFRA 0.272730498465254 0.0053154135686548 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.644890617924934 9.87630242871072e-08 NA NA NA hsa-miR-26b-5p PDGFRA -0.0183893267106221 0.882303333465809 -1.13905914639037 6.2506397545121e-07 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.402975025930207 2.59063708429956e-05 NA NA NA hsa-miR-27a-3p PDGFRA 0.140284703630369 0.213001086994521 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.594352660557639 1.41537090669377e-08 NA NA NA hsa-miR-27b-3p PDGFRA 0.0774984459252845 0.455541249499373 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.585254985067681 3.19021481160622e-07 NA NA NA hsa-miR-28-5p PDGFRA 0.189534080376749 0.0278108067630943 -1.13905914639037 6.2506397545121e-07 miRanda -0.406938460756713 0.00373490805221991 NA NA NA hsa-miR-301a-3p PDGFRA 1.23940945645189 2.05328421457283e-11 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.388942162295141 2.01835257824418e-10 NA NA NA hsa-miR-301b-3p PDGFRA 2.73590939539747 6.81394899610837e-22 -1.13905914639037 6.2506397545121e-07 MirTarget -0.223944729572515 5.89452302044413e-07 NA NA NA hsa-miR-3065-5p PDGFRA -0.963317497666877 0.000100334146005009 -1.13905914639037 6.2506397545121e-07 mirMAP -0.186804885838788 8.78388825223814e-05 NA NA NA hsa-miR-320a PDGFRA 0.25030125889857 0.0695425511666725 -1.13905914639037 6.2506397545121e-07 miRanda -0.244634331866273 0.00465279145541951 NA NA NA hsa-miR-320b PDGFRA 1.16387990475466 1.33051259463572e-10 -1.13905914639037 6.2506397545121e-07 miRanda -0.224126299935405 0.000437627446832636 NA NA NA hsa-miR-335-3p PDGFRA 0.462639143507351 0.00828753288457869 -1.13905914639037 6.2506397545121e-07 mirMAP -0.339587314302907 3.74698771774913e-07 NA NA NA hsa-miR-339-5p PDGFRA 0.695129802377533 1.42149990793285e-05 -1.13905914639037 6.2506397545121e-07 miRanda -0.591798803114689 5.05620240191466e-17 NA NA NA hsa-miR-33a-5p PDGFRA 2.10005064969044 4.16515177092697e-18 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.333686106262346 1.78205539059788e-13 NA NA NA hsa-miR-33b-5p PDGFRA 2.17368974303808 7.43919661483659e-16 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.258653316926904 4.65673794262786e-10 NA NA NA hsa-miR-362-3p PDGFRA -0.604045380242671 0.000132629619624125 -1.13905914639037 6.2506397545121e-07 miRanda -0.230067746167424 0.00214150938370685 NA NA NA hsa-miR-374a-5p PDGFRA -0.371522195407694 3.64288279697975e-05 -1.13905914639037 6.2506397545121e-07 mirMAP -0.496861578335412 0.0001765896838162 NA NA NA hsa-miR-374b-5p PDGFRA -0.490675710652087 1.35508117735881e-06 -1.13905914639037 6.2506397545121e-07 mirMAP -0.410415867238171 0.000423764904465086 NA NA NA hsa-miR-421 PDGFRA 1.16807936195133 1.4164941985739e-11 -1.13905914639037 6.2506397545121e-07 PITA;miRanda;miRNATAP -0.439041559751912 2.20930847100107e-11 NA NA NA hsa-miR-429 PDGFRA 1.44127712764248 1.7824212712414e-11 -1.13905914639037 6.2506397545121e-07 miRanda;miRNATAP -0.368496580385112 1.96183429693012e-12 NA NA NA hsa-miR-450b-5p PDGFRA 1.40607004112146 2.03869814951451e-15 -1.13905914639037 6.2506397545121e-07 mirMAP -0.230427791321645 0.000338370440146601 NA NA NA hsa-miR-454-3p PDGFRA 0.942883363058312 9.73843658862518e-10 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.491642565535569 2.47584354194241e-11 NA NA NA hsa-miR-550a-5p PDGFRA 0.762494609455337 2.22125274981609e-05 -1.13905914639037 6.2506397545121e-07 MirTarget -0.344326887538231 9.55626238079894e-08 NA NA NA hsa-miR-576-5p PDGFRA 0.993748428316612 2.24066125794743e-10 -1.13905914639037 6.2506397545121e-07 mirMAP -0.492769592943425 9.23894876040636e-12 NA NA NA hsa-miR-589-3p PDGFRA 1.64129600791754 3.03909323325799e-16 -1.13905914639037 6.2506397545121e-07 mirMAP -0.352148273808393 2.62366294332619e-10 NA NA NA hsa-miR-590-3p PDGFRA 0.9225805269779 6.0121446263776e-11 -1.13905914639037 6.2506397545121e-07 miRanda;mirMAP -0.578100854833993 5.38848727567727e-13 NA NA NA hsa-miR-590-5p PDGFRA 1.22823897140696 7.5538778278798e-17 -1.13905914639037 6.2506397545121e-07 miRanda -0.593702388548916 1.85871025512022e-15 NA NA NA hsa-miR-616-5p PDGFRA 2.3596511369846 3.26881700557061e-22 -1.13905914639037 6.2506397545121e-07 mirMAP -0.282049089334901 1.31789813322902e-09 NA NA NA hsa-miR-664a-3p PDGFRA 0.131764091487629 0.242680083678861 -1.13905914639037 6.2506397545121e-07 mirMAP -0.379736315436856 0.000341124028298507 NA NA NA hsa-miR-7-1-3p PDGFRA 1.23074353429962 9.62692371802457e-18 -1.13905914639037 6.2506397545121e-07 mirMAP -0.553066095494155 7.24442002323097e-13 NA NA NA hsa-miR-93-5p PDGFRA 1.27151657903037 1.96654008726155e-14 -1.13905914639037 6.2506397545121e-07 MirTarget;miRNATAP -0.532453222296405 1.20762357709465e-15 NA NA NA hsa-miR-944 PDGFRA 6.31318502943581 6.64615435406088e-56 -1.13905914639037 6.2506397545121e-07 mirMAP -0.173376611830046 2.37164787409335e-12 NA NA NA hsa-miR-96-5p PDGFRA 2.81159638603625 3.72452637775194e-34 -1.13905914639037 6.2506397545121e-07 TargetScan;miRNATAP -0.460136683906265 8.95833241530162e-26 NA NA NA hsa-miR-224-5p PDGFRB 2.66023106212545 6.37784852724057e-19 -0.916531706192031 1.55175948387569e-06 miRNAWalker2_validate -0.215521992769254 1.64076310908727e-12 NA NA NA hsa-miR-24-3p PDGFRB 0.272730498465254 0.0053154135686548 -0.916531706192031 1.55175948387569e-06 MirTarget -0.391676978607861 0.00011838048272515 NA NA NA hsa-miR-28-5p PDGFRB 0.189534080376749 0.0278108067630943 -0.916531706192031 1.55175948387569e-06 miRanda -0.595390115937786 2.57512183031028e-07 NA NA NA hsa-miR-29b-3p PDGFRB -0.0219237619606503 0.883966228726957 -0.916531706192031 1.55175948387569e-06 miRNATAP -0.139199599874352 0.0358599325243815 NA NA NA hsa-miR-3127-5p PDGFRB 1.29473183527726 5.09730792828934e-15 -0.916531706192031 1.55175948387569e-06 mirMAP -0.385906528439123 6.47608155143676e-12 NA NA NA hsa-miR-342-3p PDGFRB 0.34628335679908 0.0121498405984511 -0.916531706192031 1.55175948387569e-06 miRanda -0.203321655056956 0.00462869198766047 NA NA NA hsa-miR-421 PDGFRB 1.16807936195133 1.4164941985739e-11 -0.916531706192031 1.55175948387569e-06 miRanda -0.462845387105724 6.20303473239385e-18 NA NA NA hsa-miR-484 PDGFRB 0.290563207815661 0.0187067524486015 -0.916531706192031 1.55175948387569e-06 mirMAP -0.291937316299341 0.000271894254645085 NA NA NA hsa-miR-664a-3p PDGFRB 0.131764091487629 0.242680083678861 -0.916531706192031 1.55175948387569e-06 MirTarget -0.358384895810369 4.77247115066069e-05 NA NA NA hsa-miR-9-5p PDGFRB 4.97757576742384 8.49748323724349e-41 -0.916531706192031 1.55175948387569e-06 MirTarget;miRNATAP -0.171786665752665 7.64333776557556e-14 NA NA NA hsa-miR-106b-5p PDPK1 0.768146314773296 1.22330832259683e-08 -0.44847806626587 2.62559933808617e-08 mirMAP -0.148737487413825 8.47309121492914e-07 NA NA NA hsa-miR-148b-5p PDPK1 1.36450535453179 3.94217334650158e-16 -0.44847806626587 2.62559933808617e-08 mirMAP -0.123632568569266 1.84701543629285e-07 NA NA NA hsa-miR-15b-5p PDPK1 0.575042920336974 9.75508983626876e-06 -0.44847806626587 2.62559933808617e-08 mirMAP -0.132438253535901 3.04453976577002e-05 NA NA NA hsa-miR-16-5p PDPK1 0.200674510503047 0.0593717079356147 -0.44847806626587 2.62559933808617e-08 mirMAP -0.104630919996912 0.00839714612717435 NA NA NA hsa-miR-22-5p PDPK1 0.572104677310157 8.96288502279847e-06 -0.44847806626587 2.62559933808617e-08 miRNATAP -0.166253108024449 1.7908231606368e-07 NA NA NA hsa-miR-424-5p PDPK1 1.50572404087407 4.24425395615445e-20 -0.44847806626587 2.62559933808617e-08 mirMAP -0.110834950073559 3.84101207120776e-06 NA NA NA hsa-miR-505-3p PDPK1 1.02991829785126 3.27959895590399e-13 -0.44847806626587 2.62559933808617e-08 mirMAP -0.107628668698265 0.000165949254801336 NA NA NA hsa-miR-590-3p PDPK1 0.9225805269779 6.0121446263776e-11 -0.44847806626587 2.62559933808617e-08 miRanda;miRNATAP -0.155947413156548 5.00210628754515e-08 NA NA NA hsa-miR-590-5p PDPK1 1.22823897140696 7.5538778278798e-17 -0.44847806626587 2.62559933808617e-08 miRanda -0.100338085117341 0.000218044027824462 NA NA NA hsa-miR-7-1-3p PDPK1 1.23074353429962 9.62692371802457e-18 -0.44847806626587 2.62559933808617e-08 mirMAP -0.104932385836481 0.000159689841037046 NA NA NA hsa-miR-146b-5p PGF -0.432155779449763 0.00591587599739451 2.28480696828392 3.71048805624641e-21 miRanda -0.214951987677443 0.00999870517316937 NA NA NA hsa-miR-326 PGF -2.468565451901 1.23182221778132e-19 2.28480696828392 3.71048805624641e-21 mirMAP -0.38465456802148 1.51239845540085e-18 NA NA NA hsa-miR-34a-5p PGF -0.43794334019748 0.000117590706048968 2.28480696828392 3.71048805624641e-21 miRNATAP -0.335807341657723 0.0035849248246683 NA NA NA hsa-miR-126-5p PHLPP1 -1.94634635849451 2.4038399235921e-37 0.706954039810421 2.22724719517688e-06 MirTarget;miRNATAP -0.111587313207929 0.0153388555081605 NA NA NA hsa-miR-195-3p PHLPP1 -1.41416709285168 7.64629179830096e-19 0.706954039810421 2.22724719517688e-06 MirTarget -0.141690841271576 0.00217903573879293 NA NA NA hsa-miR-299-5p PHLPP1 0.541138282807162 0.0126524869126082 0.706954039810421 2.22724719517688e-06 miRNATAP -0.102804136528929 0.00412734320255127 NA NA NA hsa-miR-338-5p PHLPP1 -2.99778534642888 2.74111905046628e-39 0.706954039810421 2.22724719517688e-06 MirTarget;miRNATAP -0.142010276823533 2.71968172136598e-06 NA NA NA hsa-miR-511-5p PHLPP1 -1.56675999208301 5.80806146166175e-15 0.706954039810421 2.22724719517688e-06 MirTarget -0.155863407954033 2.37037780596886e-05 NA NA NA hsa-miR-141-5p PHLPP2 1.56175040137525 3.90005840349024e-20 -0.654077267755058 2.61583329735489e-09 MirTarget -0.140240672321443 1.01666892480199e-05 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-149-5p PHLPP2 3.1548412914629 4.44598605668453e-31 -0.654077267755058 2.61583329735489e-09 MirTarget;miRNATAP -0.109625861492155 7.83689714434812e-09 NA NA NA hsa-miR-16-5p PHLPP2 0.200674510503047 0.0593717079356147 -0.654077267755058 2.61583329735489e-09 MirTarget;miRNATAP -0.16515250290424 0.00238041446213917 NA NA NA hsa-miR-200a-3p PHLPP2 1.41385743755862 3.01641811769439e-11 -0.654077267755058 2.61583329735489e-09 MirTarget;miRNATAP -0.136210632505946 1.36507986637698e-07 NA NA NA hsa-miR-21-3p PHLPP2 0.924068840797428 6.92652443457631e-12 -0.654077267755058 2.61583329735489e-09 mirMAP -0.107511511932295 0.00966102563844732 NA NA NA hsa-miR-27a-3p PHLPP2 0.140284703630369 0.213001086994521 -0.654077267755058 2.61583329735489e-09 MirTarget;miRNATAP -0.195317966351934 0.00013464072355596 NA NA NA hsa-miR-27b-3p PHLPP2 0.0774984459252845 0.455541249499373 -0.654077267755058 2.61583329735489e-09 MirTarget;miRNATAP -0.14445368756418 0.00984489046649873 NA NA NA hsa-miR-424-5p PHLPP2 1.50572404087407 4.24425395615445e-20 -0.654077267755058 2.61583329735489e-09 MirTarget;miRNATAP -0.103568795679191 0.00178441536812175 NA NA NA hsa-miR-429 PHLPP2 1.44127712764248 1.7824212712414e-11 -0.654077267755058 2.61583329735489e-09 miRanda;miRNATAP -0.151790540309693 2.65054041451038e-09 NA NA NA hsa-miR-93-3p PHLPP2 1.87333981556813 3.67417899907584e-29 -0.654077267755058 2.61583329735489e-09 MirTarget -0.107780939267391 0.000660560253647741 NA NA NA hsa-miR-106b-5p PIK3AP1 0.768146314773296 1.22330832259683e-08 -1.58494748067469 7.24410558151522e-12 miRNAWalker2_validate -0.600468335849782 4.49950987660999e-12 NA NA NA hsa-miR-182-5p PIK3AP1 2.16789823981744 5.64205069446407e-26 -1.58494748067469 7.24410558151522e-12 MirTarget -0.407690215310004 2.38683740732893e-14 NA NA NA hsa-miR-25-3p PIK3AP1 0.324190582599831 0.0073283146172755 -1.58494748067469 7.24410558151522e-12 MirTarget -0.372923720309222 0.000218400934398943 NA NA NA hsa-miR-421 PIK3AP1 1.16807936195133 1.4164941985739e-11 -1.58494748067469 7.24410558151522e-12 miRanda -0.403602382694645 2.58041042100751e-09 NA NA NA hsa-miR-455-5p PIK3AP1 -0.00576316954435274 0.972192681692013 -1.58494748067469 7.24410558151522e-12 miRanda;miRNATAP -0.201476087446363 0.00646899061432335 NA NA NA hsa-miR-493-3p PIK3AP1 0.721339628585364 0.00182774837758595 -1.58494748067469 7.24410558151522e-12 miRNATAP -0.113239268020978 0.0310779463592998 NA NA NA hsa-miR-501-5p PIK3AP1 0.316742767698094 0.0632047358679198 -1.58494748067469 7.24410558151522e-12 miRNATAP -0.248423573403117 0.000506345189666638 NA NA NA hsa-miR-582-5p PIK3AP1 -0.0134667168827214 0.939685711149187 -1.58494748067469 7.24410558151522e-12 MirTarget -0.338894617983062 5.96411641170301e-07 NA NA NA hsa-miR-590-3p PIK3AP1 0.9225805269779 6.0121446263776e-11 -1.58494748067469 7.24410558151522e-12 miRanda -0.318408684549613 0.000158738430519456 NA NA NA hsa-miR-629-3p PIK3AP1 2.47046856327102 4.17622167602811e-39 -1.58494748067469 7.24410558151522e-12 MirTarget -0.191026035185245 0.000967444016681416 NA NA NA hsa-miR-92a-3p PIK3AP1 0.779792182638042 4.45572871602003e-09 -1.58494748067469 7.24410558151522e-12 MirTarget -0.324284510349949 0.000312403749724554 NA NA NA hsa-miR-92b-3p PIK3AP1 0.660348894715342 5.8183923925395e-06 -1.58494748067469 7.24410558151522e-12 MirTarget -0.227044424589254 0.00622662805108328 NA NA NA hsa-miR-940 PIK3AP1 1.91696621517233 1.3556247816872e-17 -1.58494748067469 7.24410558151522e-12 MirTarget -0.202903183989371 8.6480133514844e-05 NA NA NA hsa-let-7a-5p PIK3CA -0.644221394537031 9.97672106245846e-14 0.77157146359582 3.69782669315336e-09 TargetScan -0.25216251811361 0.00113783258789011 NA NA NA hsa-miR-126-5p PIK3CA -1.94634635849451 2.4038399235921e-37 0.77157146359582 3.69782669315336e-09 mirMAP -0.207094879440029 2.34127746834594e-07 NA NA NA hsa-miR-142-5p PIK3CA -0.0363288420100352 0.821716201807163 0.77157146359582 3.69782669315336e-09 mirMAP -0.188745469001615 7.62559821076363e-06 NA NA NA hsa-miR-146a-5p PIK3CA 0.260809574817216 0.135548468283814 0.77157146359582 3.69782669315336e-09 mirMAP -0.141726940379725 0.000277856368589587 NA NA NA hsa-miR-146b-5p PIK3CA -0.432155779449763 0.00591587599739451 0.77157146359582 3.69782669315336e-09 mirMAP -0.252150585099032 3.48998016089442e-09 NA NA NA hsa-miR-195-3p PIK3CA -1.41416709285168 7.64629179830096e-19 0.77157146359582 3.69782669315336e-09 mirMAP -0.136820386088504 0.000783996550406987 NA NA NA hsa-miR-338-5p PIK3CA -2.99778534642888 2.74111905046628e-39 0.77157146359582 3.69782669315336e-09 mirMAP -0.168055182926544 1.90629625599108e-10 NA NA NA hsa-miR-374b-5p PIK3CA -0.490675710652087 1.35508117735881e-06 0.77157146359582 3.69782669315336e-09 mirMAP -0.162816573843022 0.0154850104554413 NA NA NA hsa-miR-126-5p PIK3CB -1.94634635849451 2.4038399235921e-37 0.396514343076048 0.000229001542282183 mirMAP -0.121633109911592 0.000201977648367002 NA NA NA hsa-miR-29a-3p PIK3CB -1.03082784302378 5.4721714495133e-16 0.396514343076048 0.000229001542282183 miRNATAP -0.149576230880013 0.000349888356811224 NA NA NA hsa-miR-32-5p PIK3CB -0.349953074737666 0.00689126382132822 0.396514343076048 0.000229001542282183 miRNATAP -0.134863137585523 0.00161648737633337 NA NA NA hsa-miR-320b PIK3CD 1.16387990475466 1.33051259463572e-10 -0.554932415792291 0.000117207751623729 miRanda -0.112926658582406 0.00472973976851399 NA NA NA hsa-miR-324-5p PIK3CD 1.21634042749489 1.07503319022833e-13 -0.554932415792291 0.000117207751623729 miRanda -0.209872422548733 1.37615629200755e-06 NA NA NA hsa-miR-421 PIK3CD 1.16807936195133 1.4164941985739e-11 -0.554932415792291 0.000117207751623729 miRanda -0.183846708427985 1.04775206797681e-05 NA NA NA hsa-miR-484 PIK3CD 0.290563207815661 0.0187067524486015 -0.554932415792291 0.000117207751623729 MirTarget;miRNATAP -0.158343274600412 0.0087850821792869 NA NA NA hsa-miR-616-5p PIK3CD 2.3596511369846 3.26881700557061e-22 -0.554932415792291 0.000117207751623729 MirTarget -0.100397479569365 0.000684641792066849 NA NA NA hsa-miR-7-5p PIK3CD 2.15398885914606 3.95055061525106e-16 -0.554932415792291 0.000117207751623729 miRTarBase;MirTarget;miRNATAP -0.118598280971528 3.56701605381939e-05 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-942-5p PIK3CD 0.707804935292199 1.66243149466953e-05 -0.554932415792291 0.000117207751623729 MirTarget -0.174950697964601 8.61254500228352e-05 NA NA NA hsa-miR-26b-5p PIK3CG -0.0183893267106221 0.882303333465809 -2.3258158174128 2.87957414553851e-16 miRNAWalker2_validate -0.298612564603516 0.0155774613080091 NA NA NA hsa-miR-335-3p PIK3CG 0.462639143507351 0.00828753288457869 -2.3258158174128 2.87957414553851e-16 mirMAP -0.540335172961129 1.72113230573914e-10 NA NA NA hsa-miR-421 PIK3CG 1.16807936195133 1.4164941985739e-11 -2.3258158174128 2.87957414553851e-16 miRanda -0.601246768037332 6.08854911715e-13 NA NA NA hsa-miR-502-5p PIK3CG 0.377628422695461 0.0852209444874845 -2.3258158174128 2.87957414553851e-16 miRNATAP -0.422693803628237 1.29118523445362e-09 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-542-3p PIK3CG 0.0944680117124008 0.47453779285373 -2.3258158174128 2.87957414553851e-16 miRanda -0.337354615774108 0.00354330192240615 NA NA NA hsa-miR-590-3p PIK3CG 0.9225805269779 6.0121446263776e-11 -2.3258158174128 2.87957414553851e-16 miRanda -0.501615261832408 1.55536031067074e-06 NA NA NA hsa-miR-106a-5p PIK3R1 0.887689359198128 2.74215376899957e-05 -0.906081370295813 7.839065322615e-09 MirTarget;miRNATAP -0.102992160677118 0.00716933842835928 NA NA NA hsa-miR-106b-5p PIK3R1 0.768146314773296 1.22330832259683e-08 -0.906081370295813 7.839065322615e-09 MirTarget;miRNATAP -0.207423393912193 0.000511760936102047 NA NA NA hsa-miR-128-3p PIK3R1 0.940275845868474 5.3111687457665e-10 -0.906081370295813 7.839065322615e-09 MirTarget -0.142678081879032 0.00711621910364534 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 1.75268901788708 9.77575865554511e-22 -0.906081370295813 7.839065322615e-09 MirTarget -0.161339121489954 0.000126683461007503 NA NA NA hsa-miR-15b-5p PIK3R1 0.575042920336974 9.75508983626876e-06 -0.906081370295813 7.839065322615e-09 MirTarget -0.140795127070487 0.0249114796701509 NA NA NA hsa-miR-16-2-3p PIK3R1 0.505774348451832 0.00083906759991608 -0.906081370295813 7.839065322615e-09 MirTarget -0.134504354105155 0.0127486816444909 NA NA NA hsa-miR-17-5p PIK3R1 1.27106228457264 5.91314767482551e-14 -0.906081370295813 7.839065322615e-09 MirTarget;TargetScan;miRNATAP -0.21276916899942 4.50781957533375e-06 NA NA NA hsa-miR-182-5p PIK3R1 2.16789823981744 5.64205069446407e-26 -0.906081370295813 7.839065322615e-09 miRNATAP -0.143080590597343 0.000107744594885897 NA NA NA hsa-miR-185-5p PIK3R1 0.0188696639275925 0.858581663208548 -0.906081370295813 7.839065322615e-09 miRNATAP -0.289201230526188 0.000212071532148816 NA NA NA hsa-miR-188-5p PIK3R1 1.06898382373709 3.5483498326687e-08 -0.906081370295813 7.839065322615e-09 MirTarget -0.109124084065078 0.00873669966161324 NA NA NA hsa-miR-200c-3p PIK3R1 1.44830286955223 1.39903737828795e-22 -0.906081370295813 7.839065322615e-09 mirMAP -0.164960093196838 0.00156566456498898 NA NA NA hsa-miR-20a-5p PIK3R1 0.758237786270513 3.11867983980517e-05 -0.906081370295813 7.839065322615e-09 MirTarget;miRNATAP -0.161555762312386 0.000276135323122496 NA NA NA hsa-miR-21-5p PIK3R1 1.07034578283768 3.39448630342548e-28 -0.906081370295813 7.839065322615e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.364918568474881 3.21096522908236e-06 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.572104677310157 8.96288502279847e-06 -0.906081370295813 7.839065322615e-09 mirMAP -0.170867769247346 0.00692246361493034 NA NA NA hsa-miR-335-3p PIK3R1 0.462639143507351 0.00828753288457869 -0.906081370295813 7.839065322615e-09 mirMAP -0.15541768005011 0.000842753473214339 NA NA NA hsa-miR-532-3p PIK3R1 0.62928908928122 1.1124581803679e-05 -0.906081370295813 7.839065322615e-09 MirTarget -0.114242597220277 0.044804501803953 NA NA NA hsa-miR-589-3p PIK3R1 1.64129600791754 3.03909323325799e-16 -0.906081370295813 7.839065322615e-09 mirMAP -0.151191904999084 0.000109352625775656 NA NA NA hsa-miR-590-3p PIK3R1 0.9225805269779 6.0121446263776e-11 -0.906081370295813 7.839065322615e-09 miRanda;mirMAP -0.217165116306261 0.00012617346331394 NA NA NA hsa-miR-590-5p PIK3R1 1.22823897140696 7.5538778278798e-17 -0.906081370295813 7.839065322615e-09 MirTarget;PITA;miRanda;miRNATAP -0.24260092667293 4.62221232897345e-06 NA NA NA hsa-miR-629-3p PIK3R1 2.47046856327102 4.17622167602811e-39 -0.906081370295813 7.839065322615e-09 MirTarget -0.150695863506006 0.000102838090091983 NA NA NA hsa-miR-93-5p PIK3R1 1.27151657903037 1.96654008726155e-14 -0.906081370295813 7.839065322615e-09 MirTarget;miRNATAP -0.151013244461306 0.00149093163172084 NA NA NA hsa-miR-96-5p PIK3R1 2.81159638603625 3.72452637775194e-34 -0.906081370295813 7.839065322615e-09 TargetScan;miRNATAP -0.18675319095088 4.03771010202003e-09 NA NA NA hsa-miR-126-3p PIK3R2 -1.52720963398862 2.32531989121959e-20 1.2601941072408 6.07480856452617e-27 miRNAWalker2_validate;miRTarBase -0.214148738597536 3.89983786973586e-09 26384552;27578985;21249429;26191164;25240815 MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC;MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2 poor survival;;;progression;metastasis thyroid cancer;bladder cancer;breast cancer;esophageal cancer;liver cancer hsa-miR-133a-3p PIK3R2 -2.91239323338447 8.28583105925908e-27 1.2601941072408 6.07480856452617e-27 miRNAWalker2_validate -0.141874488494001 5.2411269208708e-11 NA NA NA hsa-miR-30a-5p PIK3R2 -2.98793938555326 1.93840183838367e-49 1.2601941072408 6.07480856452617e-27 miRNATAP -0.257310812662607 1.20509619987058e-22 NA NA NA hsa-miR-30b-5p PIK3R2 -1.50117013761001 1.78247435398346e-20 1.2601941072408 6.07480856452617e-27 miRNATAP -0.182301723849441 1.07309445763083e-06 NA NA NA hsa-miR-30c-5p PIK3R2 -0.426804145561029 0.00403132854321475 1.2601941072408 6.07480856452617e-27 miRNAWalker2_validate;miRNATAP -0.144815901315281 0.000819266159465651 NA NA NA hsa-miR-30d-5p PIK3R2 -2.06908130936031 2.23574479943606e-47 1.2601941072408 6.07480856452617e-27 miRNATAP -0.305303332868697 1.39154928159865e-15 NA NA NA hsa-miR-34a-5p PIK3R2 -0.43794334019748 0.000117590706048968 1.2601941072408 6.07480856452617e-27 MirTarget -0.171210388094664 0.00250655828285607 NA NA NA hsa-miR-339-5p PIK3R3 0.695129802377533 1.42149990793285e-05 -0.816244573263925 2.35715021487993e-06 MirTarget;miRanda -0.111749227899413 0.0445268908293003 NA NA NA hsa-miR-365a-3p PIK3R3 0.7862881358373 2.45551602711245e-07 -0.816244573263925 2.35715021487993e-06 MirTarget -0.274804124099582 1.75785681877552e-06 NA NA NA hsa-miR-708-3p PIK3R3 2.92078833427619 3.23244846700224e-40 -0.816244573263925 2.35715021487993e-06 mirMAP -0.102219541750713 0.00504829240288073 NA NA NA hsa-miR-92a-3p PIK3R3 0.779792182638042 4.45572871602003e-09 -0.816244573263925 2.35715021487993e-06 MirTarget;miRNATAP -0.140362863596035 0.0348566843014413 NA NA NA hsa-miR-182-5p PIK3R5 2.16789823981744 5.64205069446407e-26 -2.3436414965434 2.53372060701775e-25 MirTarget -0.574189165132763 2.40318975729578e-28 NA NA NA hsa-miR-185-5p PIK3R5 0.0188696639275925 0.858581663208548 -2.3436414965434 2.53372060701775e-25 MirTarget -0.377364831461776 0.00137943692924729 NA NA NA hsa-miR-18a-3p PIK3R5 2.05585109851169 1.40576069637563e-20 -2.3436414965434 2.53372060701775e-25 MirTarget -0.39486464722711 1.54290112654849e-14 NA NA NA hsa-miR-944 PIK3R5 6.31318502943581 6.64615435406088e-56 -2.3436414965434 2.53372060701775e-25 mirMAP -0.308952266789118 2.58901448196934e-38 NA NA NA hsa-miR-149-5p PIK3R6 3.1548412914629 4.44598605668453e-31 -1.15372799035327 7.19673848936986e-08 MirTarget -0.311167467240364 5.46578652789517e-18 NA NA NA hsa-miR-939-5p PIK3R6 1.36997300674111 9.97643104288974e-13 -1.15372799035327 7.19673848936986e-08 MirTarget -0.315172556639997 8.76510276016545e-08 NA NA NA hsa-let-7g-5p PKN2 0.0868874053614963 0.322163222422263 0.0739270129462328 0.339664183769333 miRNATAP -0.10639820677737 0.0201611331103545 NA NA NA hsa-miR-142-5p PKN2 -0.0363288420100352 0.821716201807163 0.0739270129462328 0.339664183769333 MirTarget;PITA -0.12982134972216 7.5854360066467e-08 NA NA NA hsa-miR-155-5p PKN2 0.459859353454849 0.00515473360914761 0.0739270129462328 0.339664183769333 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.123484551845078 1.61967692333967e-07 NA NA NA hsa-miR-125a-5p PPP2CA -0.463931772449969 8.22426972811352e-05 0.0530184621378922 0.415723806002177 miRanda -0.102766761976111 0.000226816139562451 NA NA NA hsa-miR-183-5p PPP2CB 2.81472476144496 4.67808720273896e-39 -0.877735637261246 1.09536229864157e-21 MirTarget;miRNATAP -0.134357665811325 2.74479967117103e-11 NA NA NA hsa-miR-421 PPP2CB 1.16807936195133 1.4164941985739e-11 -0.877735637261246 1.09536229864157e-21 miRNAWalker2_validate;miRanda -0.133985126147744 1.39198422708445e-06 NA NA NA hsa-miR-425-5p PPP2CB 0.85235119766839 8.55415485589217e-07 -0.877735637261246 1.09536229864157e-21 miRNAWalker2_validate -0.11760457780652 2.76641800305642e-05 NA NA NA hsa-miR-455-3p PPP2CB 2.18142848948175 2.92546018153478e-26 -0.877735637261246 1.09536229864157e-21 MirTarget;PITA;miRNATAP -0.110860448193174 5.72681784861239e-07 NA NA NA hsa-miR-590-3p PPP2CB 0.9225805269779 6.0121446263776e-11 -0.877735637261246 1.09536229864157e-21 miRanda -0.122910644777589 0.000338827255171532 NA NA NA hsa-miR-940 PPP2CB 1.91696621517233 1.3556247816872e-17 -0.877735637261246 1.09536229864157e-21 MirTarget;PITA -0.111283865354737 9.14238564429431e-08 NA NA NA hsa-miR-125a-5p PPP2R1B -0.463931772449969 8.22426972811352e-05 0.400007269945022 1.48419450427875e-05 PITA;miRanda -0.223763692528754 1.79185765241155e-08 NA NA NA hsa-miR-195-5p PPP2R1B -1.62452829530841 2.94084397454942e-29 0.400007269945022 1.48419450427875e-05 MirTarget -0.114405054376553 0.000163844069207574 NA NA NA hsa-miR-30a-5p PPP2R1B -2.98793938555326 1.93840183838367e-49 0.400007269945022 1.48419450427875e-05 miRNATAP -0.107745585011932 1.06953037522147e-07 NA NA NA hsa-miR-30d-5p PPP2R1B -2.06908130936031 2.23574479943606e-47 0.400007269945022 1.48419450427875e-05 miRNATAP -0.116838854187594 6.04714907990071e-05 NA NA NA hsa-miR-30e-3p PPP2R1B -0.568615785445122 1.6997540158547e-07 0.400007269945022 1.48419450427875e-05 mirMAP -0.117259157302635 0.00703955685461425 NA NA NA hsa-miR-140-3p PPP2R2A -1.5688188604984 7.06409475976727e-33 0.104035433483455 0.240232014063553 PITA -0.100235594107541 0.00145756789005806 NA NA NA hsa-miR-374a-5p PPP2R2A -0.371522195407694 3.64288279697975e-05 0.104035433483455 0.240232014063553 mirMAP -0.118891133846454 0.0187794785875583 NA NA NA hsa-miR-107 PPP2R2B -0.456345046928702 5.29231946717953e-06 0.587156911406894 0.114344242969938 miRanda -0.601182986950876 0.00155241873941449 NA NA NA hsa-miR-30e-3p PPP2R2B -0.568615785445122 1.6997540158547e-07 0.587156911406894 0.114344242969938 miRNAWalker2_validate -0.533807043820019 0.00214796919703807 NA NA NA hsa-miR-361-5p PPP2R2B -0.0236974652105824 0.799888526193556 0.587156911406894 0.114344242969938 miRanda -0.504506802706031 0.0151305629055911 NA NA NA hsa-miR-939-5p PPP2R2B 1.36997300674111 9.97643104288974e-13 0.587156911406894 0.114344242969938 MirTarget -0.215271778269162 0.0351315457289544 NA NA NA hsa-miR-181a-2-3p PPP2R2C -0.457445789885575 0.00139293397622913 5.94279963065035 4.17265370356643e-37 MirTarget -0.818182959436245 8.01032508820719e-06 NA NA NA hsa-miR-181b-5p PPP2R2C -0.578702702808657 2.41220004393722e-05 5.94279963065035 4.17265370356643e-37 mirMAP -1.18402472043482 3.10938413965721e-10 NA NA NA hsa-miR-194-5p PPP2R2C -0.249320646823728 0.0887475457808623 5.94279963065035 4.17265370356643e-37 miRNATAP -0.382453614415745 0.0352936648392365 NA NA NA hsa-miR-218-5p PPP2R2C -1.79097768150997 1.46926601815429e-27 5.94279963065035 4.17265370356643e-37 miRNATAP -0.893419444454785 1.10754910429007e-09 NA NA NA hsa-miR-34c-5p PPP2R2C -1.65096032312419 3.10893885639741e-06 5.94279963065035 4.17265370356643e-37 miRanda -0.243583624453123 0.000907478689703503 NA NA NA hsa-miR-374b-5p PPP2R2C -0.490675710652087 1.35508117735881e-06 5.94279963065035 4.17265370356643e-37 miRNATAP -1.10761155697859 1.83460349064131e-05 NA NA NA hsa-miR-500a-3p PPP2R2C 0.0997410457813883 0.420760746886716 5.94279963065035 4.17265370356643e-37 MirTarget -0.455161463747988 0.0350069261271324 NA NA NA hsa-miR-502-3p PPP2R2C -0.516137549858388 4.50135190438313e-05 5.94279963065035 4.17265370356643e-37 MirTarget;PITA;miRNATAP -0.933773514949118 6.39103375510325e-06 NA NA NA hsa-miR-542-3p PPP2R2C 0.0944680117124008 0.47453779285373 5.94279963065035 4.17265370356643e-37 miRanda -0.5241167908989 0.00942747495994353 NA NA NA hsa-miR-125a-5p PPP2R3A -0.463931772449969 8.22426972811352e-05 0.728789142146923 1.62606054840702e-06 miRanda -0.23262488010632 0.000481750695005989 NA NA NA hsa-miR-139-5p PPP2R3A -2.25560964518719 9.95317711940085e-30 0.728789142146923 1.62606054840702e-06 miRanda -0.110435698201237 0.00244395667462713 NA NA NA hsa-miR-140-5p PPP2R3A -0.615965395622439 1.05820583250804e-08 0.728789142146923 1.62606054840702e-06 PITA;miRanda;miRNATAP -0.231620773052541 0.00137258869402834 NA NA NA hsa-miR-143-3p PPP2R3A -1.50460346732144 5.17074613336112e-23 0.728789142146923 1.62606054840702e-06 miRNATAP -0.205393713455042 2.23624908220095e-05 NA NA NA hsa-miR-145-5p PPP2R3A -1.08109692150888 5.28948625689113e-14 0.728789142146923 1.62606054840702e-06 MirTarget -0.107561819268134 0.0434043441404349 NA NA NA hsa-miR-181a-5p PPP2R3A -1.31879909071317 2.04570351303734e-24 0.728789142146923 1.62606054840702e-06 MirTarget -0.243308739705734 1.94396259071192e-05 NA NA NA hsa-miR-181b-5p PPP2R3A -0.578702702808657 2.41220004393722e-05 0.728789142146923 1.62606054840702e-06 MirTarget -0.192382884734108 0.000744012335538588 NA NA NA hsa-miR-181c-5p PPP2R3A -1.36921360773694 5.61046203952059e-19 0.728789142146923 1.62606054840702e-06 MirTarget -0.177225326457358 0.000270937045707137 NA NA NA hsa-miR-181d-5p PPP2R3A -0.225424526304381 0.151955641871942 0.728789142146923 1.62606054840702e-06 MirTarget -0.124696962132708 0.0132241919194901 NA NA NA hsa-miR-26b-5p PPP2R3A -0.0183893267106221 0.882303333465809 0.728789142146923 1.62606054840702e-06 miRNATAP -0.142777169614189 0.0258875847024338 NA NA NA hsa-miR-34a-5p PPP2R3A -0.43794334019748 0.000117590706048968 0.728789142146923 1.62606054840702e-06 MirTarget;miRNATAP -0.149511157902314 0.0314222300966488 NA NA NA hsa-miR-3614-5p PPP2R3A -0.855030166480132 9.48217512568328e-06 0.728789142146923 1.62606054840702e-06 MirTarget -0.178869646681399 1.03378739066433e-05 NA NA NA hsa-miR-103a-3p PPP2R3C 0.227460152182967 0.0312044839849861 -0.72764588690697 1.85070582313e-15 MirTarget -0.149197942369312 0.00128832011582053 NA NA NA hsa-miR-361-5p PPP2R3C -0.0236974652105824 0.799888526193556 -0.72764588690697 1.85070582313e-15 miRanda -0.164695206391684 0.00180632141739446 NA NA NA hsa-miR-197-3p PPP2R5A 0.72925569501114 3.6335380891617e-08 -0.842666781412118 2.28771083589592e-11 MirTarget -0.140624003764789 0.00437065135806525 NA NA NA hsa-miR-331-3p PPP2R5B 0.954925871149262 2.04897100127988e-09 -0.411103574517115 3.62866325052953e-05 MirTarget;miRNATAP -0.10363591513681 0.000995358077426046 NA NA NA hsa-miR-744-5p PPP2R5B 0.678478047639552 1.65083384792184e-06 -0.411103574517115 3.62866325052953e-05 MirTarget -0.147958484040352 3.31035211717327e-05 NA NA NA hsa-miR-186-5p PPP2R5C 0.439819047090102 6.33375570167175e-05 -0.0914319560381269 0.245155317553426 mirMAP;miRNATAP -0.103025912046971 0.00464940379036831 NA NA NA hsa-miR-26a-5p PPP2R5C -0.929312251092796 7.48452512025337e-23 -0.0914319560381269 0.245155317553426 mirMAP -0.117217430092605 0.00370066305947559 NA NA NA hsa-miR-1976 PPP2R5D -1.13975694972151 3.52774818586224e-19 0.571046167767155 3.04404596547017e-12 MirTarget;miRNATAP -0.131201257772771 4.29229361261732e-05 NA NA NA hsa-miR-218-5p PPP2R5D -1.79097768150997 1.46926601815429e-27 0.571046167767155 3.04404596547017e-12 miRNATAP -0.125436484151579 1.61256205220867e-07 NA NA NA hsa-miR-338-3p PPP2R5D -2.39495045399875 3.50911311863594e-28 0.571046167767155 3.04404596547017e-12 miRanda -0.115771662089682 9.2737772803097e-11 NA NA NA hsa-miR-101-5p PPP2R5E -1.43344889913165 4.24447181596161e-20 0.358863843599019 0.00019699923972451 MirTarget -0.180903586656734 1.00446469281201e-09 NA NA NA hsa-miR-125a-5p PPP2R5E -0.463931772449969 8.22426972811352e-05 0.358863843599019 0.00019699923972451 miRNAWalker2_validate -0.173825154826856 3.13458988055206e-05 NA NA NA hsa-miR-126-5p PPP2R5E -1.94634635849451 2.4038399235921e-37 0.358863843599019 0.00019699923972451 MirTarget;mirMAP -0.130918505157333 7.19550055670033e-06 NA NA NA hsa-miR-139-5p PPP2R5E -2.25560964518719 9.95317711940085e-30 0.358863843599019 0.00019699923972451 miRanda -0.122475679226218 6.05358573000251e-08 NA NA NA hsa-miR-146b-5p PPP2R5E -0.432155779449763 0.00591587599739451 0.358863843599019 0.00019699923972451 miRanda -0.148774749187931 1.85876456443302e-06 NA NA NA hsa-miR-181a-5p PPP2R5E -1.31879909071317 2.04570351303734e-24 0.358863843599019 0.00019699923972451 MirTarget;mirMAP -0.173319501612439 1.19093034347723e-06 NA NA NA hsa-miR-181b-5p PPP2R5E -0.578702702808657 2.41220004393722e-05 0.358863843599019 0.00019699923972451 MirTarget;mirMAP -0.143687534419919 5.81938366789086e-05 NA NA NA hsa-miR-181c-5p PPP2R5E -1.36921360773694 5.61046203952059e-19 0.358863843599019 0.00019699923972451 MirTarget;mirMAP -0.168763940829442 2.38334074914289e-08 NA NA NA hsa-miR-181d-5p PPP2R5E -0.225424526304381 0.151955641871942 0.358863843599019 0.00019699923972451 MirTarget -0.103203739836609 0.00106810299702586 NA NA NA hsa-miR-29b-2-5p PPP2R5E -1.04734214410093 8.2886590108117e-14 0.358863843599019 0.00019699923972451 mirMAP -0.163803728357795 1.33758632153096e-06 NA NA NA hsa-miR-30a-5p PPP2R5E -2.98793938555326 1.93840183838367e-49 0.358863843599019 0.00019699923972451 mirMAP -0.137461889900458 4.74617819099405e-11 NA NA NA hsa-miR-30b-5p PPP2R5E -1.50117013761001 1.78247435398346e-20 0.358863843599019 0.00019699923972451 mirMAP -0.125327940836209 1.37636144305905e-05 NA NA NA hsa-miR-30c-5p PPP2R5E -0.426804145561029 0.00403132854321475 0.358863843599019 0.00019699923972451 mirMAP -0.186124464420017 1.41739567090067e-08 NA NA NA hsa-miR-30d-3p PPP2R5E -1.57797039577408 4.48970383848141e-24 0.358863843599019 0.00019699923972451 MirTarget -0.118143016564612 6.91045325725225e-05 NA NA NA hsa-miR-30d-5p PPP2R5E -2.06908130936031 2.23574479943606e-47 0.358863843599019 0.00019699923972451 mirMAP -0.139866565983014 3.6648351253634e-06 NA NA NA hsa-miR-30e-5p PPP2R5E 0.186424244301373 0.077486249643257 0.358863843599019 0.00019699923972451 mirMAP -0.172363598340815 0.000264286999703103 NA NA NA hsa-miR-342-3p PPP2R5E 0.34628335679908 0.0121498405984511 0.358863843599019 0.00019699923972451 miRanda -0.102014110938352 0.00452288598222227 NA NA NA hsa-miR-374a-5p PPP2R5E -0.371522195407694 3.64288279697975e-05 0.358863843599019 0.00019699923972451 mirMAP -0.328240807400829 1.65763434305996e-09 NA NA NA hsa-miR-374b-5p PPP2R5E -0.490675710652087 1.35508117735881e-06 0.358863843599019 0.00019699923972451 mirMAP -0.192402202000361 7.15594341614117e-05 NA NA NA hsa-miR-16-5p PRKAA1 0.200674510503047 0.0593717079356147 -0.106649346138357 0.257341821343416 MirTarget -0.151804047802161 0.000834364052696386 NA NA NA hsa-let-7b-3p PRKAA2 -0.39527315467518 0.0023287663817318 -0.037763934816712 0.889646219645976 mirMAP -0.354083308679286 0.000946634192058616 NA NA NA hsa-let-7b-5p PRKAA2 -0.759197439090238 1.31014217546415e-10 -0.037763934816712 0.889646219645976 miRNAWalker2_validate;MirTarget -0.280301759709847 0.0155593487118916 NA NA NA hsa-let-7c-5p PRKAA2 -1.09524404011671 7.33221488714214e-09 -0.037763934816712 0.889646219645976 MirTarget -0.202415585795709 0.00493292785933284 NA NA NA hsa-let-7i-5p PRKAA2 0.140484500715033 0.0901764941286614 -0.037763934816712 0.889646219645976 MirTarget -0.524282505334712 0.00221686566482987 NA NA NA hsa-miR-142-5p PRKAA2 -0.0363288420100352 0.821716201807163 -0.037763934816712 0.889646219645976 mirMAP -0.32049859941925 0.000203476242290711 NA NA NA hsa-miR-146a-5p PRKAA2 0.260809574817216 0.135548468283814 -0.037763934816712 0.889646219645976 MirTarget -0.381176869413569 1.36180341122485e-06 NA NA NA hsa-miR-195-3p PRKAA2 -1.41416709285168 7.64629179830096e-19 -0.037763934816712 0.889646219645976 mirMAP -0.198724386183554 0.0170653837424653 NA NA NA hsa-miR-22-5p PRKAA2 0.572104677310157 8.96288502279847e-06 -0.037763934816712 0.889646219645976 mirMAP -0.336628567160884 0.0017019041476728 NA NA NA hsa-miR-23a-3p PRKAA2 -0.0903829051318041 0.377264294498572 -0.037763934816712 0.889646219645976 mirMAP -0.363189369535394 0.00844198261766449 NA NA NA hsa-miR-27b-5p PRKAA2 0.820842093948362 1.02062095078579e-08 -0.037763934816712 0.889646219645976 MirTarget;miRNATAP -0.188856158421933 0.0486443967042569 NA NA NA hsa-miR-342-3p PRKAA2 0.34628335679908 0.0121498405984511 -0.037763934816712 0.889646219645976 PITA -0.207140627237488 0.0407080862525526 NA NA NA hsa-miR-103a-2-5p PRKCA 1.89326161187553 3.13008877983253e-17 -0.974587037180898 1.59667717677333e-07 mirMAP -0.255032219136495 5.66138192625884e-10 NA NA NA hsa-miR-130b-5p PRKCA 2.72304481328307 1.8934343274629e-43 -0.974587037180898 1.59667717677333e-07 mirMAP -0.199037664820712 4.06802135705539e-06 NA NA NA hsa-miR-183-5p PRKCA 2.81472476144496 4.67808720273896e-39 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.240368910307629 1.25472912124441e-09 NA NA NA hsa-miR-186-5p PRKCA 0.439819047090102 6.33375570167175e-05 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.444964803892211 3.16155563438696e-07 NA NA NA hsa-miR-200b-3p PRKCA 1.24269422431788 9.2707509169586e-11 -0.974587037180898 1.59667717677333e-07 TargetScan -0.313065635516529 7.15711567733287e-11 NA NA NA hsa-miR-200c-3p PRKCA 1.44830286955223 1.39903737828795e-22 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.383905416235595 2.03345956113349e-10 NA NA NA hsa-miR-22-5p PRKCA 0.572104677310157 8.96288502279847e-06 -0.974587037180898 1.59667717677333e-07 mirMAP -0.157092998678219 0.0358226565459193 NA NA NA hsa-miR-224-5p PRKCA 2.66023106212545 6.37784852724057e-19 -0.974587037180898 1.59667717677333e-07 mirMAP -0.123745547319231 4.93478296821349e-05 NA NA NA hsa-miR-24-2-5p PRKCA 0.712627789969659 1.71500628519945e-07 -0.974587037180898 1.59667717677333e-07 miRNAWalker2_validate -0.291904426050533 2.80886742073414e-05 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.820842093948362 1.02062095078579e-08 -0.974587037180898 1.59667717677333e-07 mirMAP -0.218882892673469 0.000957982501639593 NA NA NA hsa-miR-3200-3p PRKCA 1.96851854609803 5.39282273222562e-13 -0.974587037180898 1.59667717677333e-07 mirMAP -0.144473582704466 2.27891123348531e-05 NA NA NA hsa-miR-330-3p PRKCA 0.00879260240870505 0.951284239507664 -0.974587037180898 1.59667717677333e-07 mirMAP -0.173921930769027 0.0101218155060833 NA NA NA hsa-miR-339-5p PRKCA 0.695129802377533 1.42149990793285e-05 -0.974587037180898 1.59667717677333e-07 mirMAP -0.172694365689272 0.0039120388533714 NA NA NA hsa-miR-340-5p PRKCA 0.172446891226333 0.176440862972852 -0.974587037180898 1.59667717677333e-07 mirMAP -0.263808839161941 0.000528963031822328 NA NA NA hsa-miR-362-5p PRKCA 0.26329593259106 0.182949931130249 -0.974587037180898 1.59667717677333e-07 TargetScan;miRNATAP -0.233671646700469 1.40291932449976e-06 NA NA NA hsa-miR-3651 PRKCA 2.10082404452515 2.98369800438194e-16 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.159096760500619 2.77083109550502e-05 NA NA NA hsa-miR-374a-5p PRKCA -0.371522195407694 3.64288279697975e-05 -0.974587037180898 1.59667717677333e-07 mirMAP -0.457049988104694 2.17430433002093e-05 NA NA NA hsa-miR-374b-5p PRKCA -0.490675710652087 1.35508117735881e-06 -0.974587037180898 1.59667717677333e-07 mirMAP -0.227098219306743 0.0171366832485277 NA NA NA hsa-miR-429 PRKCA 1.44127712764248 1.7824212712414e-11 -0.974587037180898 1.59667717677333e-07 miRanda;miRNATAP -0.297274954617902 3.2900114769435e-12 NA NA NA hsa-miR-450b-5p PRKCA 1.40607004112146 2.03869814951451e-15 -0.974587037180898 1.59667717677333e-07 PITA;mirMAP;miRNATAP -0.138949561878445 0.00822008096081412 NA NA NA hsa-miR-452-5p PRKCA 1.08242667876786 2.34127628858457e-06 -0.974587037180898 1.59667717677333e-07 mirMAP -0.151885839949413 0.000246288161636881 NA NA NA hsa-miR-500a-5p PRKCA 0.202654345352218 0.2571507084955 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.20050668312658 0.000202040081839628 NA NA NA hsa-miR-501-5p PRKCA 0.316742767698094 0.0632047358679198 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.284119476152452 4.27308273993988e-07 NA NA NA hsa-miR-505-3p PRKCA 1.02991829785126 3.27959895590399e-13 -0.974587037180898 1.59667717677333e-07 miRNAWalker2_validate -0.263404546436633 6.72111840547781e-05 NA NA NA hsa-miR-505-5p PRKCA 1.28871267080216 1.00459615050289e-12 -0.974587037180898 1.59667717677333e-07 mirMAP -0.212525280280474 3.77064550378066e-05 NA NA NA hsa-miR-532-3p PRKCA 0.62928908928122 1.1124581803679e-05 -0.974587037180898 1.59667717677333e-07 mirMAP;miRNATAP -0.262642335929359 8.25955081866384e-05 NA NA NA hsa-miR-550a-3p PRKCA 0.725364459738765 3.06985443364331e-05 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.116847969995496 0.0359346885491844 NA NA NA hsa-miR-590-3p PRKCA 0.9225805269779 6.0121446263776e-11 -0.974587037180898 1.59667717677333e-07 PITA;miRanda;mirMAP;miRNATAP -0.369292193663921 2.38016145358297e-08 NA NA NA hsa-miR-616-5p PRKCA 2.3596511369846 3.26881700557061e-22 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.162909099430841 2.1546696298556e-05 NA NA NA hsa-miR-760 PRKCA 2.46800133673516 9.92808266371112e-19 -0.974587037180898 1.59667717677333e-07 mirMAP -0.148177491878182 9.88240047234202e-06 NA NA NA hsa-miR-9-5p PRKCA 4.97757576742384 8.49748323724349e-41 -0.974587037180898 1.59667717677333e-07 miRNATAP -0.100596860659178 1.22633371086721e-05 NA NA NA hsa-miR-92a-3p PRKCA 0.779792182638042 4.45572871602003e-09 -0.974587037180898 1.59667717677333e-07 miRNAWalker2_validate -0.190615711505641 0.00781826586492611 NA NA NA hsa-miR-93-3p PRKCA 1.87333981556813 3.67417899907584e-29 -0.974587037180898 1.59667717677333e-07 mirMAP -0.332588260358556 2.24648012233656e-10 NA NA NA hsa-miR-944 PRKCA 6.31318502943581 6.64615435406088e-56 -0.974587037180898 1.59667717677333e-07 PITA;miRNATAP -0.120292401892904 3.28375624432008e-09 NA NA NA hsa-let-7d-5p PRLR 0.0470413504723624 0.6502410569426 0.0561360911187287 0.89182338816415 miRNATAP -0.609169244542006 0.00312745255260129 NA NA NA hsa-let-7f-1-3p PRLR 0.0152174523424196 0.909387255829372 0.0561360911187287 0.89182338816415 mirMAP -0.364086179057515 0.0226370276763687 NA NA NA hsa-let-7f-5p PRLR -0.247755606925729 0.0395456675844559 0.0561360911187287 0.89182338816415 miRNATAP -0.421642849353564 0.0170748538098831 NA NA NA hsa-let-7g-5p PRLR 0.0868874053614963 0.322163222422263 0.0561360911187287 0.89182338816415 miRNATAP -0.483864287564357 0.0492564297309141 NA NA NA hsa-miR-126-5p PRLR -1.94634635849451 2.4038399235921e-37 0.0561360911187287 0.89182338816415 mirMAP -0.296824199750702 0.0180731386730181 NA NA NA hsa-miR-29a-5p PRLR 0.140889123110504 0.311453338790787 0.0561360911187287 0.89182338816415 mirMAP -0.301301251081668 0.0490752004426021 NA NA NA hsa-miR-3614-5p PRLR -0.855030166480132 9.48217512568328e-06 0.0561360911187287 0.89182338816415 mirMAP -0.231815893518829 0.0346984006978211 NA NA NA hsa-miR-362-5p PRLR 0.26329593259106 0.182949931130249 0.0561360911187287 0.89182338816415 mirMAP -0.300668297219081 0.00486462359961088 NA NA NA hsa-miR-374a-5p PRLR -0.371522195407694 3.64288279697975e-05 0.0561360911187287 0.89182338816415 mirMAP -0.713968247609803 0.00251514698930534 NA NA NA hsa-miR-576-5p PRLR 0.993748428316612 2.24066125794743e-10 0.0561360911187287 0.89182338816415 mirMAP -0.327929451405982 0.0129297239321143 NA NA NA hsa-miR-582-5p PRLR -0.0134667168827214 0.939685711149187 0.0561360911187287 0.89182338816415 PITA -0.490316473706067 3.3296692236961e-05 NA NA NA hsa-miR-589-3p PRLR 1.64129600791754 3.03909323325799e-16 0.0561360911187287 0.89182338816415 mirMAP -0.221066416474671 0.0292104305832028 NA NA NA hsa-miR-616-5p PRLR 2.3596511369846 3.26881700557061e-22 0.0561360911187287 0.89182338816415 mirMAP -0.223111967380513 0.00813168029807366 NA NA NA hsa-miR-7-1-3p PRLR 1.23074353429962 9.62692371802457e-18 0.0561360911187287 0.89182338816415 mirMAP -0.368877887844308 0.00894082473247572 NA NA NA hsa-miR-944 PRLR 6.31318502943581 6.64615435406088e-56 0.0561360911187287 0.89182338816415 mirMAP -0.133299535926649 0.00314877505582008 NA NA NA hsa-miR-103a-3p PTEN 0.227460152182967 0.0312044839849861 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase -0.454321278471926 6.17119533898015e-10 26511107;24828205 LncRNA GAS5 induces PTEN expression through inhibiting miR 103 in endometrial cancer cells; To investigate the expression of GAS5 PTEN and miR-103 RT-PCR was performed; Finally we found that miR-103 mimic could decrease the mRNA and protein levels of PTEN through luciferase reporter assay and western blotting and GAS5 plasmid may reverse this regulation effect in endometrial cancer cells; Through inhibiting the expression of miR-103 GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis and thus could be an important mediator in the pathogenesis of endometrial cancer;Our data collectively demonstrate that miR-103 is an oncogene miRNA that promotes colorectal cancer proliferation and migration through down-regulation of the tumor suppressor genes DICER and PTEN ; endometrial cancer;colorectal cancer hsa-miR-106a-5p PTEN 0.887689359198128 2.74215376899957e-05 -0.688909080717938 5.29057005002921e-06 miRNATAP -0.159193889422333 1.17308296468727e-05 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-106b-5p PTEN 0.768146314773296 1.22330832259683e-08 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.327853127291429 5.59142491594729e-09 24842611;26238857;26722252 MicroRNA 106b in cancer associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;We further identified PTEN and p21 as novel direct targets of miR-106b by using target prediction algorithms and a luciferase assay; Overexpression of miR-106b reduced the expression of PTEN and p21 and increased the expression of p-AKT which is a downstream of PTEN; Restoring the expression of PTEN or p21 in stably miR-106b-overexpressed cells could rescue the effect of miR-106b on cell radioresistance; These observations illustrated that miR-106b could induce cell radioresistance by directly targeting PTEN and p21 this process was accompanied by tumour-initiating cell capacity enhancement which is universally confirmed to be associated with radioresistance;Cantharidin modulates the E2F1/MCM7 miR 106b 93/p21 PTEN signaling axis in MCF 7 breast cancer cells cell migration;drug resistance; gastric cancer;colorectal cancer;breast cancer hsa-miR-130b-3p PTEN 2.60393336883065 1.5273795648739e-42 -0.688909080717938 5.29057005002921e-06 MirTarget;miRNATAP -0.211237799199477 4.23619588270054e-09 26837847;25637514 The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC cell migration; bladder cancer;esophageal cancer hsa-miR-141-3p PTEN 1.96958415696982 1.4648441542521e-24 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.239638911570474 1.25155958993282e-10 27644195;24742567 Involvement of microRNA 141 3p in 5 fluorouracil and oxaliplatin chemo resistance in esophageal cancer cells via regulation of PTEN; Western blot exhibited altered protein levels of PTEN Akt and PI3k with miR-141-3p inhibitor; An inverse correlation between PTEN expression and miR-141-3p expression was also observed in tissue samples; Our study demonstrated that miR-141-3p contributed to an acquired chemo-resistance through PTEN modulation both in vitro and in vivo;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis drug resistance;tumorigenesis esophageal cancer;endometrial cancer hsa-miR-15b-3p PTEN 0.720785796663996 5.61234325663636e-07 -0.688909080717938 5.29057005002921e-06 mirMAP -0.253423330189972 1.94011581697214e-06 NA NA NA hsa-miR-16-2-3p PTEN 0.505774348451832 0.00083906759991608 -0.688909080717938 5.29057005002921e-06 mirMAP -0.215359566477413 2.62489555913938e-05 NA NA NA hsa-miR-17-5p PTEN 1.27106228457264 5.91314767482551e-14 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.281129348398515 1.32485513031545e-10 27400681;23391506;23133552;26629823;24462867;26318586;26215320;25634356;26500892;24912422;23418359 GFRα2 prompts cell growth and chemoresistance through down regulating tumor suppressor gene PTEN via Mir 17 5p in pancreatic cancer; Mechanically we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level;We found that these phenotypes were the results of miR-17 targeting PTEN;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;We hypothesized that knocking down the oncogenic microRNA oncomiR miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor proteins illustrating a route to oligonucleotide therapy of TNBC; Contrary to conventional wisdom antisense knockdown of oncomiR miR-17-5p guide strand reduced PDCD4 and PTEN proteins by 1.8±0.3 fold in human TNBC cells instead of raising them; Bioinformatics analysis and folding energy calculations revealed that mRNA targets of miR-17-5p guide strand such as PDCD4 and PTEN could also be regulated by miR-17-3p passenger strand;miR 17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression; Expression of miR-17 was negatively correlated with PTEN in OS tissues;Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR 17 family in prostate cancer; Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo;In addition ERβ expression significantly increased in calycosin-treated HCT-116 cells followed by a decrease of miR-17 and up-regulation of PTEN; Our results indicate that calycosin has an inhibitory effect on CRC which might be obtained by ERβ-mediated regulation of miR-17 and PTEN expression;The High Expression of the microRNA 17 92 Cluster and its Paralogs and the Downregulation of the Target Gene PTEN Is Associated with Primary Cutaneous B Cell Lymphoma Progression;MicroRNA 17 5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling; miR-17-5p activates AKT by downregulation of PTEN in ovarian cancer cells;MicroRNA 17 5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression; We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance; Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance; MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;The mature miR-17-5p exerted this function by repressing the expression of PTEN drug resistance;;;;metastasis;;;progression;drug resistance;metastasis;drug resistance;poor survival; pancreatic cancer;glioblastoma;sarcoma;breast cancer;sarcoma;prostate cancer;colorectal cancer;B cell lymphoma;ovarian cancer;colorectal cancer;liver cancer hsa-miR-181d-5p PTEN -0.225424526304381 0.151955641871942 -0.688909080717938 5.29057005002921e-06 MirTarget -0.119415660363902 0.0170234560903413 27006767 Moreover hsa-miR-181d was upregulated to control expression a tumor suppressor gene PTEN to protect the cancer cell from apoptosis endometrial cancer hsa-miR-182-5p PTEN 2.16789823981744 5.64205069446407e-26 -0.688909080717938 5.29057005002921e-06 mirMAP -0.242009457277314 2.43951932532396e-12 NA NA NA hsa-miR-186-5p PTEN 0.439819047090102 6.33375570167175e-05 -0.688909080717938 5.29057005002921e-06 mirMAP;miRNATAP -0.30089841400017 2.15177087545997e-05 NA NA NA hsa-miR-188-5p PTEN 1.06898382373709 3.5483498326687e-08 -0.688909080717938 5.29057005002921e-06 MirTarget;PITA;miRNATAP -0.168157264558752 2.05522117017233e-05 NA NA NA hsa-miR-18a-5p PTEN 0.941249745535531 1.37246345065862e-06 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase -0.252712760340658 6.8029481622476e-11 24681249;27291152 However higher levels of the miR-17~92 cluster switched from PTEN to oncogenes including Ctnnb1 β-catenin via miR-18a which resulted in inhibition of tumor growth and metastasis;miR 18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN PI3K AKT mTOR signaling axis metastasis; colon cancer;esophageal cancer hsa-miR-19a-3p PTEN 1.29022522620563 7.13786738838458e-11 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.193428644413625 3.76529920698819e-07 26098000;27289489;27445062;24831732;21853360;24681249;25107371 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Transfection of miR-19a and -19b mimics reversed the up-regulations of IGF2R and PTEN gene expression and abrogated the GSE induced anti-proliferative response;The target genes of miR-19a such as ABCA1 and PTEN that had been suppressed by miR recovered their expression through CAP treatment;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN;The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid; Meanwhile gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN; The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN ;drug resistance;;;drug resistance;metastasis; lung cancer;lung cancer;breast cancer;breast cancer;breast cancer;colon cancer;bladder cancer hsa-miR-19b-3p PTEN 0.786722036548617 1.29623163115342e-06 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.224665161987238 1.88641309143493e-06 26098000;24831732;21853360;24681249 Moreover siRNA-mediated knockdown of PTEN a target of miR-19 also resulted in EMT migration and invasion of A549 and HCC827 cells suggesting that PTEN is involved in miR-19-induced EMT migration and invasion of lung cancer cells;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin;Regulation of miR 19 to breast cancer chemoresistance through targeting PTEN; Expression levels of miR-19 in MDR cells were inversely consistent with those of PTEN; Our findings demonstrate for the first time involvement of miR-19 in multidrug resistance through modulation of PTEN and suggest that miR-19 may be a potential target for preventing and reversing MDR in tumor cells;miR-19 in the context of the miR-17~92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin-mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene PTEN ;;drug resistance;metastasis lung cancer;breast cancer;breast cancer;colon cancer hsa-miR-200a-3p PTEN 1.41385743755862 3.01641811769439e-11 -0.688909080717938 5.29057005002921e-06 miRNATAP -0.204383601148329 6.2841627535852e-09 22637745;24742567;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; We found loss of expression of miR-200a b and c in chemo-resistant PC cell lines which was correlated with loss of PTEN and over-expression of MT1-MMP; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ;tumorigenesis; pancreatic cancer;endometrial cancer;pancreatic cancer hsa-miR-200b-3p PTEN 1.24269422431788 9.2707509169586e-11 -0.688909080717938 5.29057005002921e-06 TargetScan;mirMAP -0.201557062543955 2.92280370691908e-07 22637745;21408027 Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants ; pancreatic cancer;pancreatic cancer hsa-miR-200c-3p PTEN 1.44830286955223 1.39903737828795e-22 -0.688909080717938 5.29057005002921e-06 mirMAP;miRNATAP -0.283222621742824 8.05196886183932e-09 24682933;22637745 In conclusion miR-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis survival invasion and metastasis as well as xenograft tumor growth through inhibition of PTEN expression and p53 phosphorylation;Forced over-expression or silencing of miR-200c followed by either CDF or BR-DIM treatment of MIAPaCa-2 cells altered the morphology of cells wound-healing capacity colony formation and the expression of MT1-MMP and PTEN; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment metastasis;poor survival; colon cancer;pancreatic cancer hsa-miR-20a-5p PTEN 0.758237786270513 3.11867983980517e-05 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.227978389591612 5.75100360459444e-08 26031366 The expression of miR-20a and PTEN were detected in HCC cell lines and paired primary tissues by quantitative real-time polymerase chain reaction; MiR-20a levels were increased in HCC cell lines and tissues whereas PTEN was inversely correlated with it; PTEN was identified as a direct functional target of miR-20a for the induction of radioresistance drug resistance liver cancer hsa-miR-25-3p PTEN 0.324190582599831 0.0073283146172755 -0.688909080717938 5.29057005002921e-06 miRTarBase;MirTarget;miRNATAP -0.227689477715449 0.000447948220864927 NA NA NA hsa-miR-26b-5p PTEN -0.0183893267106221 0.882303333465809 -0.688909080717938 5.29057005002921e-06 MirTarget;miRNATAP -0.168990087148694 0.00789956865785443 26068649 Down regulation of microRNA 26b modulates non small cell lung cancer cells chemoresistance and migration through the association of PTEN; It indicates that miR-26b may regulate NSCLC migration and chemosensitivity through the regulation of PTEN drug resistance lung squamous cell cancer hsa-miR-28-5p PTEN 0.189534080376749 0.0278108067630943 -0.688909080717938 5.29057005002921e-06 miRanda -0.208073983021413 0.0248819844969875 NA NA NA hsa-miR-301a-3p PTEN 1.23940945645189 2.05328421457283e-11 -0.688909080717938 5.29057005002921e-06 MirTarget;miRNATAP -0.242502274581067 2.03200146299192e-09 24315818;26846737 Upregulated microRNA 301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β catenin signaling; Furthermore miR-301a directly targeted and suppressed PTEN one negative regulator of the Wnt/β-catenin signaling cascade; These results demonstrate that miR-301a maintains constitutively activated Wnt/β-catenin signaling by directly targeting PTEN which promotes breast cancer invasion and metastasis;MicroRNA 301a promotes cell proliferation via PTEN targeting in Ewing's sarcoma cells; Our results demonstrated the novel mechanism controlling PTEN expression via miR-301a in ES cells metastasis; breast cancer;sarcoma hsa-miR-301b-3p PTEN 2.73590939539747 6.81394899610837e-22 -0.688909080717938 5.29057005002921e-06 MirTarget -0.185254001156165 2.49804525512304e-10 NA NA NA hsa-miR-30c-5p PTEN -0.426804145561029 0.00403132854321475 -0.688909080717938 5.29057005002921e-06 mirMAP -0.114146890350332 0.030767606849104 NA NA NA hsa-miR-32-5p PTEN -0.349953074737666 0.00689126382132822 -0.688909080717938 5.29057005002921e-06 MirTarget;miRNATAP -0.238781040532095 7.53027727010743e-05 24123284;25647261;23617834 In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC; The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction; The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed; Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues; An inverse relationship between miR-32 and PTEN protein expression was identified; MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR 32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN; Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway; Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment;MicroRNA 32 miR 32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells; In this study we identified the potential effects of miR-32 on some important biological properties of CRC cells and clarified the regulation of PTEN by miR-32; The 3'-untranslated region 3'-UTR of PTEN combined with miR-32 was verified by dual-luciferase reporter assay; Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level; However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein; In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN; Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN ;;tumorigenesis colorectal cancer;liver cancer;colorectal cancer hsa-miR-320a PTEN 0.25030125889857 0.0695425511666725 -0.688909080717938 5.29057005002921e-06 MirTarget;PITA;miRanda;miRNATAP -0.167847349158718 0.00322196630123518 NA NA NA hsa-miR-320b PTEN 1.16387990475466 1.33051259463572e-10 -0.688909080717938 5.29057005002921e-06 MirTarget;PITA;miRanda;miRNATAP -0.136597010239809 0.00117171396311702 NA NA NA hsa-miR-335-3p PTEN 0.462639143507351 0.00828753288457869 -0.688909080717938 5.29057005002921e-06 MirTarget -0.151268844264663 0.000673292553931903 NA NA NA hsa-miR-340-5p PTEN 0.172446891226333 0.176440862972852 -0.688909080717938 5.29057005002921e-06 miRNATAP -0.275643007033422 6.89427109517262e-06 NA NA NA hsa-miR-342-3p PTEN 0.34628335679908 0.0121498405984511 -0.688909080717938 5.29057005002921e-06 miRanda -0.136598051022139 0.0163755047889355 NA NA NA hsa-miR-3613-5p PTEN 0.3786284075683 0.0120072636174458 -0.688909080717938 5.29057005002921e-06 miRNATAP -0.1410289216671 0.00668015871440489 NA NA NA hsa-miR-374a-5p PTEN -0.371522195407694 3.64288279697975e-05 -0.688909080717938 5.29057005002921e-06 MirTarget;mirMAP -0.252750282337674 0.00395314445192739 NA NA NA hsa-miR-374b-5p PTEN -0.490675710652087 1.35508117735881e-06 -0.688909080717938 5.29057005002921e-06 MirTarget;mirMAP;miRNATAP -0.296537313023265 0.000109617322178734 NA NA NA hsa-miR-421 PTEN 1.16807936195133 1.4164941985739e-11 -0.688909080717938 5.29057005002921e-06 miRanda -0.330573204294515 1.23032371957368e-14 NA NA NA hsa-miR-425-5p PTEN 0.85235119766839 8.55415485589217e-07 -0.688909080717938 5.29057005002921e-06 miRNATAP -0.240262509414892 4.71102473740042e-08 25154996 An increase in miR-425 depended upon IL-1β-induced NF-kappaB activation.Repression of PTEN by miR-425 promoted gastric cancer cell proliferation gastric cancer hsa-miR-429 PTEN 1.44127712764248 1.7824212712414e-11 -0.688909080717938 5.29057005002921e-06 PITA;miRanda;mirMAP;miRNATAP -0.222492255980761 1.47915110524957e-10 NA NA NA hsa-miR-452-5p PTEN 1.08242667876786 2.34127628858457e-06 -0.688909080717938 5.29057005002921e-06 mirMAP -0.123816427592097 0.000222606728149269 NA NA NA hsa-miR-454-3p PTEN 0.942883363058312 9.73843658862518e-10 -0.688909080717938 5.29057005002921e-06 MirTarget;miRNATAP -0.293573163915826 1.84795557347818e-09 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-590-3p PTEN 0.9225805269779 6.0121446263776e-11 -0.688909080717938 5.29057005002921e-06 MirTarget;PITA;miRanda;mirMAP -0.198858675587987 0.000242757239061311 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting; miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation liver cancer hsa-miR-590-5p PTEN 1.22823897140696 7.5538778278798e-17 -0.688909080717938 5.29057005002921e-06 mirMAP -0.189236546421301 0.000198404642627814 23803188 Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting liver cancer hsa-miR-628-3p PTEN 0.96307364947779 2.68891601773546e-06 -0.688909080717938 5.29057005002921e-06 MirTarget;PITA -0.146434683046845 0.000170636812544959 NA NA NA hsa-miR-7-1-3p PTEN 1.23074353429962 9.62692371802457e-18 -0.688909080717938 5.29057005002921e-06 mirMAP -0.225507775887291 1.40809411916725e-05 NA NA NA hsa-miR-708-3p PTEN 2.92078833427619 3.23244846700224e-40 -0.688909080717938 5.29057005002921e-06 mirMAP -0.105416684499158 0.0009115853468056 NA NA NA hsa-miR-92a-3p PTEN 0.779792182638042 4.45572871602003e-09 -0.688909080717938 5.29057005002921e-06 MirTarget;miRNATAP -0.238902729991438 3.39661741481605e-05 26432332;25515201;24137349;23546593;23133552;24026406 Downregulation of PTEN could mimic the same effects of miR-92a mimic in NSCLC cells and rescue the effects on NSCLC cells induced by miR-92a inhibitor; Taken together these findings suggested that miR-92a could promote growth metastasis and chemoresistance in NSCLC cells at least partially by targeting PTEN;MiR 92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN Mediated PI3K/AKT Pathway; The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; In addition there was a negative correlation between levels of miR-92a and the PTEN gene p < 0.0001; The association of levels of miR-92a and PTEN with tumor cell migration in CRC was also confirmed in CRC cell models;MicroRNA miR-92 is overexpressed in a number of tumors and has been proven to negatively regulate a number of tumor suppressor genes including phosphatase and tensin homologue PTEN; PTEN protein expression was decreased in the SiHa cells that were transfected with the miR-92 mimic; The data indicated that miR-92 may increase the migration and invasion of SiHa cells partially through the downregulation of PTEN protein expression;Expression and significance of PTEN and miR 92 in hepatocellular carcinoma; Immunohistochemistry streptavidin-peroxidase SP and quantitative reverse transcriptase-polymerase chain reaction qRT‑PCR were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues; The correlation between PTEN and miR-92 was analyzed; Additionally the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other r=-0.858 P<0.05; In conclusion PTEN and miR-92 have different roles in the development of HCC; The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC;PTEN mRNA correlated inversely with miR-92a and members of the miR-17 and miR-130/301 families;The expression levels of miR-92a and phosphatase and tensin homologue PTEN were detected by qRT-PCR and western blot; In addition the regulation of PTEN by miR-92a was evaluated by qRT-PCR western blot and luciferase reporter assays; There was an inverse correlation between the levels of miR-92a and PTEN in CRC tissues; The overexpression of miR-92a in CRC cells decreased PTEN expression at the translational level and decreased PTEN-driven luciferase-reporter activity; Our results demonstrated that miR-92a induced EMT and regulated cell growth migration and invasion in the SW480 cells at least partially via suppression of PTEN expression metastasis;drug resistance;metastasis;cell migration;;worse prognosis;; lung squamous cell cancer;colorectal cancer;cervical and endocervical cancer;liver cancer;sarcoma;colorectal cancer hsa-miR-93-5p PTEN 1.27151657903037 1.96654008726155e-14 -0.688909080717938 5.29057005002921e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.268012172782447 1.98835206373031e-09 25633810;26243299;22465665;26087719 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression ;tumorigenesis;;poor survival liver cancer;sarcoma;ovarian cancer;ovarian cancer hsa-miR-139-5p PTK2 -2.25560964518719 9.95317711940085e-30 0.306353980411506 0.000180373687709759 miRanda -0.118848414872386 4.24326496232157e-10 NA NA NA hsa-miR-140-5p PTK2 -0.615965395622439 1.05820583250804e-08 0.306353980411506 0.000180373687709759 miRanda -0.218395736533801 8.79567419114695e-09 NA NA NA hsa-miR-101-3p RAC1 -2.01992291103908 2.62945171087274e-42 0.250880057409908 0.00539650431157478 miRNAWalker2_validate;MirTarget -0.120348031111413 1.27653744639191e-05 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-194-5p RAC1 -0.249320646823728 0.0887475457808623 0.250880057409908 0.00539650431157478 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128224530115258 4.41117704741103e-05 NA NA NA hsa-miR-374a-3p RAC1 -0.104091172625131 0.359725600505889 0.250880057409908 0.00539650431157478 MirTarget;miRNATAP -0.108997799965721 0.00785900648079917 NA NA NA hsa-miR-374a-5p RAC1 -0.371522195407694 3.64288279697975e-05 0.250880057409908 0.00539650431157478 mirMAP -0.202290701712647 8.26703308150516e-05 NA NA NA hsa-miR-374b-5p RAC1 -0.490675710652087 1.35508117735881e-06 0.250880057409908 0.00539650431157478 mirMAP -0.187833285476651 3.06438120555453e-05 NA NA NA hsa-miR-652-3p RAC1 -0.94860016726992 1.06677320772785e-10 0.250880057409908 0.00539650431157478 miRNAWalker2_validate -0.103385417493413 0.000733505728442039 NA NA NA hsa-miR-106b-5p RBL2 0.768146314773296 1.22330832259683e-08 -0.705344184840391 5.85159672680451e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.147006588571741 3.17857341441988e-06 NA NA NA hsa-miR-17-5p RBL2 1.27106228457264 5.91314767482551e-14 -0.705344184840391 5.85159672680451e-18 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.114459835632353 3.48262997029453e-06 NA NA NA hsa-miR-590-3p RBL2 0.9225805269779 6.0121446263776e-11 -0.705344184840391 5.85159672680451e-18 miRanda -0.145978167607191 1.09439694653653e-06 NA NA NA hsa-miR-629-3p RBL2 2.47046856327102 4.17622167602811e-39 -0.705344184840391 5.85159672680451e-18 MirTarget -0.105877109867983 2.34915559839788e-07 NA NA NA hsa-miR-128-3p RELN 0.940275845868474 5.3111687457665e-10 -2.87177416670412 2.00738250672402e-14 miRNAWalker2_validate;miRTarBase;MirTarget -0.494428950561561 0.000117723511666561 NA NA NA hsa-miR-129-5p RELN 2.0409652261565 1.19491474689015e-07 -2.87177416670412 2.00738250672402e-14 miRanda -0.136270031520828 0.00727987279327891 NA NA NA hsa-miR-15a-5p RELN -0.24629041301676 0.0253630661893983 -2.87177416670412 2.00738250672402e-14 MirTarget;miRNATAP -0.469643022786395 0.0101596626770697 NA NA NA hsa-miR-15b-5p RELN 0.575042920336974 9.75508983626876e-06 -2.87177416670412 2.00738250672402e-14 MirTarget;miRNATAP -0.966980039945736 8.95779421431023e-11 NA NA NA hsa-miR-16-5p RELN 0.200674510503047 0.0593717079356147 -2.87177416670412 2.00738250672402e-14 MirTarget;miRNATAP -0.661733157855894 0.000456320095047436 NA NA NA hsa-miR-200b-3p RELN 1.24269422431788 9.2707509169586e-11 -2.87177416670412 2.00738250672402e-14 MirTarget;TargetScan -0.556477316285519 2.43799474683357e-08 NA NA NA hsa-miR-200c-3p RELN 1.44830286955223 1.39903737828795e-22 -2.87177416670412 2.00738250672402e-14 MirTarget -0.972611238472132 2.22212932119096e-15 NA NA NA hsa-miR-205-5p RELN 7.4255450988826 2.64056553520099e-76 -2.87177416670412 2.00738250672402e-14 miRNATAP -0.393925061787415 1.60448683573846e-25 NA NA NA hsa-miR-224-5p RELN 2.66023106212545 6.37784852724057e-19 -2.87177416670412 2.00738250672402e-14 MirTarget -0.476965871533853 5.65928221187048e-15 NA NA NA hsa-miR-27a-3p RELN 0.140284703630369 0.213001086994521 -2.87177416670412 2.00738250672402e-14 MirTarget;miRNATAP -1.15561781730938 3.68660136677986e-11 NA NA NA hsa-miR-27b-3p RELN 0.0774984459252845 0.455541249499373 -2.87177416670412 2.00738250672402e-14 MirTarget;miRNATAP -1.00314027139692 1.7778412569283e-07 NA NA NA hsa-miR-331-5p RELN 0.782866941570431 7.91287242315309e-09 -2.87177416670412 2.00738250672402e-14 MirTarget;miRNATAP -0.767421824558056 7.60730511066111e-08 NA NA NA hsa-miR-421 RELN 1.16807936195133 1.4164941985739e-11 -2.87177416670412 2.00738250672402e-14 miRanda -0.54843517551684 9.07614602930747e-07 NA NA NA hsa-miR-424-5p RELN 1.50572404087407 4.24425395615445e-20 -2.87177416670412 2.00738250672402e-14 MirTarget;miRNATAP -0.643851677451416 1.48736209320671e-08 NA NA NA hsa-miR-429 RELN 1.44127712764248 1.7824212712414e-11 -2.87177416670412 2.00738250672402e-14 MirTarget;PITA;miRanda;miRNATAP -0.480519780048743 6.96833249539036e-08 NA NA NA hsa-miR-452-5p RELN 1.08242667876786 2.34127628858457e-06 -2.87177416670412 2.00738250672402e-14 MirTarget -0.514447174857249 9.45264075559436e-10 NA NA NA hsa-miR-455-3p RELN 2.18142848948175 2.92546018153478e-26 -2.87177416670412 2.00738250672402e-14 PITA -0.409468475550537 4.73287008239593e-06 NA NA NA hsa-miR-589-3p RELN 1.64129600791754 3.03909323325799e-16 -2.87177416670412 2.00738250672402e-14 MirTarget -0.596314562011401 1.82845407860652e-10 NA NA NA hsa-miR-590-3p RELN 0.9225805269779 6.0121446263776e-11 -2.87177416670412 2.00738250672402e-14 miRanda;miRNATAP -0.644318147278603 2.65665453010956e-06 NA NA NA hsa-miR-155-5p RHEB 0.459859353454849 0.00515473360914761 0.374029822971655 3.74364823625376e-05 miRNAWalker2_validate;miRNATAP -0.120892447838691 1.74079011679679e-05 NA NA NA hsa-miR-126-5p RPS6KB1 -1.94634635849451 2.4038399235921e-37 0.373261361525414 4.4997339777717e-06 mirMAP -0.133213438575785 5.72200431325474e-08 NA NA NA hsa-miR-139-5p RPS6KB1 -2.25560964518719 9.95317711940085e-30 0.373261361525414 4.4997339777717e-06 PITA;miRanda -0.10426246681745 5.07121420215761e-08 NA NA NA hsa-miR-145-5p RPS6KB1 -1.08109692150888 5.28948625689113e-14 0.373261361525414 4.4997339777717e-06 MirTarget;miRNATAP -0.191222850498509 3.76864298596675e-12 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-181a-5p RPS6KB1 -1.31879909071317 2.04570351303734e-24 0.373261361525414 4.4997339777717e-06 MirTarget;miRNATAP -0.13355178414748 1.03805232576368e-05 NA NA NA hsa-miR-199a-5p RPS6KB1 0.125189495212204 0.398433974759894 0.373261361525414 4.4997339777717e-06 miRanda -0.133179204950499 2.20080833968928e-06 NA NA NA hsa-miR-199b-5p RPS6KB1 -0.116511382952145 0.446612289886567 0.373261361525414 4.4997339777717e-06 miRanda -0.115485576915784 2.35599211189032e-05 NA NA NA hsa-miR-218-5p RPS6KB1 -1.79097768150997 1.46926601815429e-27 0.373261361525414 4.4997339777717e-06 miRNATAP -0.112713658426396 1.51368900749022e-06 25943352 We found that decreased miR-218 expression in GBM cells also increased the expression of genes encoding additional upstream and downstream components of RTK signaling pathways including the RTK platelet-derived growth factor receptor α PDGFRα and the kinases ribosomal S6 kinase 2 RSK2 and S6 kinase 1 S6K1 that collectively overrode the negative feedback mechanism glioblastoma hsa-miR-30a-5p RPS6KB1 -2.98793938555326 1.93840183838367e-49 0.373261361525414 4.4997339777717e-06 mirMAP;miRNATAP -0.1030363539201 7.12125142300186e-09 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.463931772449969 8.22426972811352e-05 0.739582850005122 6.31985502410921e-12 miRanda -0.127419036560908 0.00795515885009352 NA NA NA hsa-miR-361-3p RPS6KB2 -0.491157107537441 1.38504517485595e-06 0.739582850005122 6.31985502410921e-12 miRNATAP -0.14992254843897 0.00695114289410687 NA NA NA hsa-miR-361-3p RPTOR -0.491157107537441 1.38504517485595e-06 0.21628120121028 0.014877422041505 MirTarget -0.173477305729664 8.98092608731486e-05 NA NA NA hsa-miR-342-3p RXRA 0.34628335679908 0.0121498405984511 -0.106083746100486 0.412360614501953 miRanda -0.111665496885847 0.0200164921251505 NA NA NA hsa-miR-125a-3p SGK1 -0.490390905488357 0.00628500185334301 0.0435278752681096 0.824897382708049 miRanda -0.243077822640078 1.23819699319647e-05 NA NA NA hsa-miR-455-5p SGK2 -0.00576316954435274 0.972192681692013 -0.00853199060294374 0.976807071094388 miRanda -0.184050328856179 0.0437721039249703 NA NA NA hsa-miR-21-5p SGK3 1.07034578283768 3.39448630342548e-28 -0.581773136621998 4.19668056634005e-07 miRNAWalker2_validate -0.284338106329781 5.80553649240471e-07 NA NA NA hsa-miR-1976 SOS1 -1.13975694972151 3.52774818586224e-19 0.320158062782566 2.15118385690153e-05 MirTarget -0.108036316990894 0.000190186014522611 NA NA NA hsa-miR-22-5p SOS1 0.572104677310157 8.96288502279847e-06 0.320158062782566 2.15118385690153e-05 miRNATAP -0.122192459952918 3.881354969978e-05 NA NA NA hsa-miR-130b-3p SOS2 2.60393336883065 1.5273795648739e-42 -0.528468936106962 6.84651998177735e-10 miRNATAP -0.134406479674269 4.28964002826023e-11 NA NA NA hsa-miR-148a-3p SOS2 0.601028293839963 9.92248185893877e-05 -0.528468936106962 6.84651998177735e-10 miRNATAP -0.131558475995767 3.91090114351045e-06 NA NA NA hsa-miR-15b-5p SOS2 0.575042920336974 9.75508983626876e-06 -0.528468936106962 6.84651998177735e-10 miRNATAP -0.159914101892138 2.27633913494599e-06 NA NA NA hsa-miR-16-5p SOS2 0.200674510503047 0.0593717079356147 -0.528468936106962 6.84651998177735e-10 miRNATAP -0.172631218755255 4.20812452609115e-05 NA NA NA hsa-miR-21-5p SOS2 1.07034578283768 3.39448630342548e-28 -0.528468936106962 6.84651998177735e-10 miRNATAP -0.139839842903208 0.00115299157136772 NA NA NA hsa-miR-424-5p SOS2 1.50572404087407 4.24425395615445e-20 -0.528468936106962 6.84651998177735e-10 miRNATAP -0.104615051862577 4.74911115067869e-05 NA NA NA hsa-miR-454-3p SOS2 0.942883363058312 9.73843658862518e-10 -0.528468936106962 6.84651998177735e-10 miRNATAP -0.104067438972835 0.00023160799836153 NA NA NA hsa-miR-590-3p SOS2 0.9225805269779 6.0121446263776e-11 -0.528468936106962 6.84651998177735e-10 miRanda;mirMAP -0.165405356171743 6.34269022129331e-08 NA NA NA hsa-miR-590-5p SOS2 1.22823897140696 7.5538778278798e-17 -0.528468936106962 6.84651998177735e-10 PITA;miRanda;miRNATAP -0.135330482467521 2.70700308274873e-06 NA NA NA hsa-miR-139-5p SPP1 -2.25560964518719 9.95317711940085e-30 4.27506077822025 3.72185087642959e-30 miRanda -0.533206839384894 1.95146476248462e-08 NA NA NA hsa-miR-3065-5p SPP1 -0.963317497666877 0.000100334146005009 4.27506077822025 3.72185087642959e-30 miRNATAP -0.238674016885349 0.00446182817228887 NA NA NA hsa-miR-335-5p SPP1 -0.324086861750615 0.0899025346373434 4.27506077822025 3.72185087642959e-30 miRNAWalker2_validate -0.308886697793463 0.00457249282843842 NA NA NA hsa-miR-34c-5p SPP1 -1.65096032312419 3.10893885639741e-06 4.27506077822025 3.72185087642959e-30 miRanda -0.156304199875796 0.00694761464372098 NA NA NA hsa-miR-362-3p SPP1 -0.604045380242671 0.000132629619624125 4.27506077822025 3.72185087642959e-30 miRanda -0.681269288731727 1.56022016474701e-07 NA NA NA hsa-miR-330-3p STK11 0.00879260240870505 0.951284239507664 0.44270575232633 7.66870810439385e-06 mirMAP -0.129879251022179 0.000257315355383152 NA NA NA hsa-miR-330-5p STK11 0.168243129357275 0.239196436552122 0.44270575232633 7.66870810439385e-06 miRanda -0.101369585481185 0.004721223068329 NA NA NA hsa-miR-130b-5p SYK 2.72304481328307 1.8934343274629e-43 -0.472776602319313 0.000987290325446997 mirMAP -0.103928533154914 0.00174437806361707 NA NA NA hsa-miR-25-3p SYK 0.324190582599831 0.0073283146172755 -0.472776602319313 0.000987290325446997 mirMAP -0.18490522200579 0.00253545049905755 NA NA NA hsa-miR-421 SYK 1.16807936195133 1.4164941985739e-11 -0.472776602319313 0.000987290325446997 miRanda -0.143871990891302 0.000552280812385826 NA NA NA hsa-miR-877-5p SYK 2.90093737151303 2.52134268016683e-35 -0.472776602319313 0.000987290325446997 mirMAP -0.157403429821431 4.34546119048505e-08 NA NA NA hsa-miR-99b-3p SYK -0.260140699290343 0.124097065961821 -0.472776602319313 0.000987290325446997 miRNAWalker2_validate -0.166108664890059 0.000133433775712863 NA NA NA hsa-miR-421 TEK 1.16807936195133 1.4164941985739e-11 -4.43796639332711 2.27633199223746e-63 miRanda -0.682177612567391 8.77455598522064e-15 NA NA NA hsa-miR-455-5p TEK -0.00576316954435274 0.972192681692013 -4.43796639332711 2.27633199223746e-63 miRanda -0.244805634172298 0.0121898554269313 NA NA NA hsa-miR-140-3p TGFA -1.5688188604984 7.06409475976727e-33 1.47515566454995 9.99649942678786e-12 miRNATAP -0.31437947412985 7.56781030228815e-05 NA NA NA hsa-miR-181a-5p TGFA -1.31879909071317 2.04570351303734e-24 1.47515566454995 9.99649942678786e-12 mirMAP -0.331215805076677 6.16206531341593e-05 NA NA NA hsa-miR-181b-5p TGFA -0.578702702808657 2.41220004393722e-05 1.47515566454995 9.99649942678786e-12 mirMAP -0.28747649674932 0.000502225513005045 NA NA NA hsa-miR-181c-5p TGFA -1.36921360773694 5.61046203952059e-19 1.47515566454995 9.99649942678786e-12 mirMAP -0.371090985996639 1.07380555332659e-07 NA NA NA hsa-miR-29b-2-5p TGFA -1.04734214410093 8.2886590108117e-14 1.47515566454995 9.99649942678786e-12 mirMAP -0.407634417507443 1.6762069737499e-07 NA NA NA hsa-miR-326 TGFA -2.468565451901 1.23182221778132e-19 1.47515566454995 9.99649942678786e-12 miRanda -0.186614024383046 2.31884002383191e-06 NA NA NA hsa-miR-335-3p TGFA 0.462639143507351 0.00828753288457869 1.47515566454995 9.99649942678786e-12 mirMAP -0.181130145522828 0.00533831260237713 NA NA NA hsa-miR-338-5p TGFA -2.99778534642888 2.74111905046628e-39 1.47515566454995 9.99649942678786e-12 mirMAP -0.245269595356358 3.31149539355127e-08 NA NA NA hsa-miR-342-3p TGFA 0.34628335679908 0.0121498405984511 1.47515566454995 9.99649942678786e-12 miRanda -0.198292382057849 0.0168380311408429 NA NA NA hsa-let-7a-3p THBS1 0.0442588630386531 0.71354010406076 -1.79184272768187 5.09934430999088e-14 mirMAP -0.22241718834789 0.0356974393345043 NA NA NA hsa-let-7d-5p THBS1 0.0470413504723624 0.6502410569426 -1.79184272768187 5.09934430999088e-14 miRNAWalker2_validate -0.487831455104317 6.999600384963e-05 NA NA NA hsa-miR-151a-3p THBS1 0.292162840926293 0.0110038890457677 -1.79184272768187 5.09934430999088e-14 MirTarget -0.287929758420504 0.00923518215690513 NA NA NA hsa-miR-16-1-3p THBS1 -0.156899711138322 0.214597270113743 -1.79184272768187 5.09934430999088e-14 MirTarget -0.466010805494786 2.89629156833668e-06 NA NA NA hsa-miR-17-5p THBS1 1.27106228457264 5.91314767482551e-14 -1.79184272768187 5.09934430999088e-14 miRNAWalker2_validate -0.706425391648194 1.27849872045645e-25 NA NA NA hsa-miR-182-5p THBS1 2.16789823981744 5.64205069446407e-26 -1.79184272768187 5.09934430999088e-14 MirTarget -0.512842987381738 3.27114820303694e-21 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 0.439819047090102 6.33375570167175e-05 -1.79184272768187 5.09934430999088e-14 mirMAP -0.423113462559832 0.000219092187701942 NA NA NA hsa-miR-18a-5p THBS1 0.941249745535531 1.37246345065862e-06 -1.79184272768187 5.09934430999088e-14 MirTarget -0.528911151806884 5.09743677075343e-18 NA NA NA hsa-miR-19a-3p THBS1 1.29022522620563 7.13786738838458e-11 -1.79184272768187 5.09934430999088e-14 MirTarget;mirMAP -0.52284612594096 1.24059975709993e-18 NA NA NA hsa-miR-19b-3p THBS1 0.786722036548617 1.29623163115342e-06 -1.79184272768187 5.09934430999088e-14 MirTarget;mirMAP -0.632044912342877 8.08248712811953e-18 NA NA NA hsa-miR-200a-5p THBS1 1.8625149656411 2.00715507468494e-20 -1.79184272768187 5.09934430999088e-14 MirTarget -0.436204808345014 3.47562452331023e-14 NA NA NA hsa-miR-200b-5p THBS1 2.1000866113144 2.48742582531618e-25 -1.79184272768187 5.09934430999088e-14 MirTarget -0.492992091255305 9.46243733960325e-19 NA NA NA hsa-miR-20a-5p THBS1 0.758237786270513 3.11867983980517e-05 -1.79184272768187 5.09934430999088e-14 miRNAWalker2_validate -0.588439867288163 2.64475138189785e-19 NA NA NA hsa-miR-32-5p THBS1 -0.349953074737666 0.00689126382132822 -1.79184272768187 5.09934430999088e-14 mirMAP -0.43523726646909 7.11039949179328e-06 NA NA NA hsa-miR-335-3p THBS1 0.462639143507351 0.00828753288457869 -1.79184272768187 5.09934430999088e-14 mirMAP -0.309575526421018 1.43716053176287e-05 NA NA NA hsa-miR-33a-3p THBS1 0.540032749009224 0.00270907254062352 -1.79184272768187 5.09934430999088e-14 MirTarget;mirMAP -0.356940595717409 3.1746021722412e-07 NA NA NA hsa-miR-421 THBS1 1.16807936195133 1.4164941985739e-11 -1.79184272768187 5.09934430999088e-14 miRanda -0.471394106268219 1.34705097358786e-11 NA NA NA hsa-miR-450b-5p THBS1 1.40607004112146 2.03869814951451e-15 -1.79184272768187 5.09934430999088e-14 MirTarget -0.328191813890638 1.32627622818769e-06 NA NA NA hsa-miR-500a-5p THBS1 0.202654345352218 0.2571507084955 -1.79184272768187 5.09934430999088e-14 mirMAP -0.359216368128065 2.67357412018151e-07 NA NA NA hsa-miR-576-5p THBS1 0.993748428316612 2.24066125794743e-10 -1.79184272768187 5.09934430999088e-14 mirMAP -0.455688921622033 3.95422894660273e-09 NA NA NA hsa-miR-577 THBS1 3.5197399300515 1.67960995324817e-16 -1.79184272768187 5.09934430999088e-14 mirMAP -0.184588099920632 3.05482837266416e-09 NA NA NA hsa-miR-589-3p THBS1 1.64129600791754 3.03909323325799e-16 -1.79184272768187 5.09934430999088e-14 mirMAP -0.368529732418857 5.07497645239904e-10 NA NA NA hsa-miR-590-3p THBS1 0.9225805269779 6.0121446263776e-11 -1.79184272768187 5.09934430999088e-14 miRanda -0.572655629351906 2.19476347944769e-11 NA NA NA hsa-miR-590-5p THBS1 1.22823897140696 7.5538778278798e-17 -1.79184272768187 5.09934430999088e-14 miRanda;mirMAP -0.605998948857402 2.77202181681738e-14 NA NA NA hsa-miR-616-5p THBS1 2.3596511369846 3.26881700557061e-22 -1.79184272768187 5.09934430999088e-14 mirMAP -0.327373847314942 2.82260109347059e-11 NA NA NA hsa-miR-629-3p THBS1 2.47046856327102 4.17622167602811e-39 -1.79184272768187 5.09934430999088e-14 MirTarget -0.302731296750001 3.38241142667462e-07 NA NA NA hsa-miR-664a-3p THBS1 0.131764091487629 0.242680083678861 -1.79184272768187 5.09934430999088e-14 mirMAP -0.497810491486853 9.09555091884762e-06 NA NA NA hsa-miR-671-5p THBS1 2.24826787094975 1.21091062273857e-36 -1.79184272768187 5.09934430999088e-14 MirTarget -0.511040703287318 1.31505624704583e-16 NA NA NA hsa-miR-7-1-3p THBS1 1.23074353429962 9.62692371802457e-18 -1.79184272768187 5.09934430999088e-14 MirTarget;mirMAP -0.593089207921523 4.38595204638208e-13 NA NA NA hsa-miR-92a-3p THBS1 0.779792182638042 4.45572871602003e-09 -1.79184272768187 5.09934430999088e-14 miRNAWalker2_validate -0.686675427931655 3.21668739892092e-14 NA NA NA hsa-miR-940 THBS1 1.91696621517233 1.3556247816872e-17 -1.79184272768187 5.09934430999088e-14 MirTarget -0.219299733010864 4.10641546732214e-05 NA NA NA hsa-miR-944 THBS1 6.31318502943581 6.64615435406088e-56 -1.79184272768187 5.09934430999088e-14 MirTarget;PITA -0.221855612114165 1.00466951388694e-17 NA NA NA hsa-miR-98-5p THBS1 0.278359437335009 0.00921227131925612 -1.79184272768187 5.09934430999088e-14 miRNAWalker2_validate -0.611286252500222 1.99373867008563e-07 NA NA NA hsa-miR-106a-5p THBS2 0.887689359198128 2.74215376899957e-05 2.00924880869339 1.88816295069645e-13 MirTarget -0.385347825043396 6.71634226382598e-09 NA NA NA hsa-miR-106b-5p THBS2 0.768146314773296 1.22330832259683e-08 2.00924880869339 1.88816295069645e-13 MirTarget -0.684119857219048 3.41543706226479e-11 NA NA NA hsa-miR-139-5p THBS2 -2.25560964518719 9.95317711940085e-30 2.00924880869339 1.88816295069645e-13 miRanda -0.411140073898527 3.69481345112788e-10 NA NA NA hsa-miR-16-2-3p THBS2 0.505774348451832 0.00083906759991608 2.00924880869339 1.88816295069645e-13 mirMAP -0.561605642701606 1.88920113864146e-09 NA NA NA hsa-miR-17-5p THBS2 1.27106228457264 5.91314767482551e-14 2.00924880869339 1.88816295069645e-13 MirTarget;TargetScan -0.304248480561088 0.000218359128715082 NA NA NA hsa-miR-20a-5p THBS2 0.758237786270513 3.11867983980517e-05 2.00924880869339 1.88816295069645e-13 MirTarget -0.33755497921612 1.56549556664091e-05 NA NA NA hsa-miR-20b-5p THBS2 0.396943783991848 0.194012869265072 2.00924880869339 1.88816295069645e-13 MirTarget -0.285849217020535 6.53332610997545e-10 NA NA NA hsa-miR-29a-3p THBS2 -1.03082784302378 5.4721714495133e-16 2.00924880869339 1.88816295069645e-13 MirTarget -0.252966943315755 0.0213675978709667 NA NA NA hsa-miR-29b-3p THBS2 -0.0219237619606503 0.883966228726957 2.00924880869339 1.88816295069645e-13 MirTarget -0.229681410392753 0.0177527606820847 NA NA NA hsa-miR-29c-3p THBS2 -1.50225173284958 1.90087771871443e-16 2.00924880869339 1.88816295069645e-13 MirTarget -0.178149716066163 0.0192156506108541 NA NA NA hsa-miR-320a THBS2 0.25030125889857 0.0695425511666725 2.00924880869339 1.88816295069645e-13 mirMAP -0.290846105503503 0.0057519609961794 NA NA NA hsa-miR-335-3p THBS2 0.462639143507351 0.00828753288457869 2.00924880869339 1.88816295069645e-13 MirTarget;mirMAP -0.292904128356272 0.000360703599418567 NA NA NA hsa-miR-3614-5p THBS2 -0.855030166480132 9.48217512568328e-06 2.00924880869339 1.88816295069645e-13 miRNATAP -0.25514410768299 0.000653389891858857 NA NA NA hsa-miR-582-3p THBS2 -0.459710681681138 0.0173047578986498 2.00924880869339 1.88816295069645e-13 miRNATAP -0.458018627542308 3.92975370058034e-10 NA NA NA hsa-miR-590-3p THBS2 0.9225805269779 6.0121446263776e-11 2.00924880869339 1.88816295069645e-13 miRanda;mirMAP -0.26491665497569 0.00840217714097313 NA NA NA hsa-miR-590-5p THBS2 1.22823897140696 7.5538778278798e-17 2.00924880869339 1.88816295069645e-13 miRanda -0.284205250545748 0.00256010970440904 NA NA NA hsa-miR-598-3p THBS2 -1.00056215486139 1.71007056062481e-07 2.00924880869339 1.88816295069645e-13 MirTarget -0.326717778774596 9.50866003680958e-06 NA NA NA hsa-miR-7-1-3p THBS2 1.23074353429962 9.62692371802457e-18 2.00924880869339 1.88816295069645e-13 MirTarget;mirMAP -0.233573912310113 0.0157622569625163 NA NA NA hsa-miR-93-5p THBS2 1.27151657903037 1.96654008726155e-14 2.00924880869339 1.88816295069645e-13 MirTarget -0.313919434736901 0.000176978197565225 NA NA NA hsa-miR-96-5p THBS2 2.81159638603625 3.72452637775194e-34 2.00924880869339 1.88816295069645e-13 TargetScan;miRNATAP -0.147145274261463 0.00995032712765577 NA NA NA hsa-miR-106b-5p TLR2 0.768146314773296 1.22330832259683e-08 -1.56915991771034 1.04252300944762e-22 miRNAWalker2_validate -0.628745440579717 3.50863347769161e-26 NA NA NA hsa-miR-19a-3p TLR2 1.29022522620563 7.13786738838458e-11 -1.56915991771034 1.04252300944762e-22 miRNAWalker2_validate;miRTarBase -0.284422280854437 9.09161377287012e-12 NA NA NA hsa-miR-19b-3p TLR2 0.786722036548617 1.29623163115342e-06 -1.56915991771034 1.04252300944762e-22 miRNAWalker2_validate;miRTarBase -0.330267082461721 1.71998131601934e-10 NA NA NA hsa-miR-320a TLR2 0.25030125889857 0.0695425511666725 -1.56915991771034 1.04252300944762e-22 miRanda -0.148834585322493 0.018883668197248 NA NA NA hsa-miR-320b TLR2 1.16387990475466 1.33051259463572e-10 -1.56915991771034 1.04252300944762e-22 miRanda -0.290335996598134 2.36674153880936e-10 NA NA NA hsa-miR-335-5p TLR2 -0.324086861750615 0.0899025346373434 -1.56915991771034 1.04252300944762e-22 miRNAWalker2_validate -0.174661461559465 0.00011425268879002 NA NA NA hsa-miR-542-3p TLR2 0.0944680117124008 0.47453779285373 -1.56915991771034 1.04252300944762e-22 miRanda -0.259751537530039 8.1488495518156e-05 NA NA NA hsa-miR-590-3p TLR2 0.9225805269779 6.0121446263776e-11 -1.56915991771034 1.04252300944762e-22 miRanda -0.420268885373357 8.04842675605916e-13 NA NA NA hsa-miR-17-5p TLR4 1.27106228457264 5.91314767482551e-14 -2.83336077512844 7.97593513687583e-31 TargetScan -0.738249574703289 9.57651742170169e-24 NA NA NA hsa-miR-21-5p TLR4 1.07034578283768 3.39448630342548e-28 -2.83336077512844 7.97593513687583e-31 miRNAWalker2_validate -0.542437972957118 3.50243474209588e-05 27286259 For in vivo relevance expression of TLR4 was correlated with miR-21 expression and ROS production in freshly isolated untreated primary human lung cancer cells lung cancer hsa-miR-331-5p TLR4 0.782866941570431 7.91287242315309e-09 -2.83336077512844 7.97593513687583e-31 MirTarget -0.727268974289694 3.60207013071567e-14 NA NA NA hsa-miR-369-3p TLR4 1.01732933007745 5.62255655622001e-06 -2.83336077512844 7.97593513687583e-31 miRNATAP -0.181898894831283 0.00259230527678257 NA NA NA hsa-miR-421 TLR4 1.16807936195133 1.4164941985739e-11 -2.83336077512844 7.97593513687583e-31 miRanda -0.550831048870796 2.1528320840342e-13 NA NA NA hsa-miR-542-3p TLR4 0.0944680117124008 0.47453779285373 -2.83336077512844 7.97593513687583e-31 miRanda -0.273270828586408 0.00872960283518243 NA NA NA hsa-miR-590-3p TLR4 0.9225805269779 6.0121446263776e-11 -2.83336077512844 7.97593513687583e-31 miRanda;mirMAP -0.540344385264596 7.01302942638575e-09 NA NA NA hsa-miR-590-5p TLR4 1.22823897140696 7.5538778278798e-17 -2.83336077512844 7.97593513687583e-31 miRanda -0.792010647587595 7.78374810828036e-21 NA NA NA hsa-miR-7-1-3p TLR4 1.23074353429962 9.62692371802457e-18 -2.83336077512844 7.97593513687583e-31 mirMAP -0.655552606746768 1.29396341765391e-13 NA NA NA hsa-miR-7-5p TLR4 2.15398885914606 3.95055061525106e-16 -2.83336077512844 7.97593513687583e-31 MirTarget -0.358011703347713 4.52928463283507e-12 24004462 Our recent evidence showed that Toll like receptor 9 TLR9 signaling could enhance the growth and metastatic potential of human lung cancer cells through repressing microRNA-7 miR-7 expression lung cancer hsa-miR-944 TLR4 6.31318502943581 6.64615435406088e-56 -2.83336077512844 7.97593513687583e-31 miRNATAP -0.318529138393031 1.83640048608235e-32 NA NA NA hsa-miR-126-5p TNC -1.94634635849451 2.4038399235921e-37 1.46586319167032 4.78288244358886e-06 miRNATAP -0.444585481701892 5.50883172998439e-06 NA NA NA hsa-miR-218-5p TNC -1.79097768150997 1.46926601815429e-27 1.46586319167032 4.78288244358886e-06 MirTarget;miRNATAP -0.224258261990387 0.0169807846329467 NA NA NA hsa-miR-326 TNC -2.468565451901 1.23182221778132e-19 1.46586319167032 4.78288244358886e-06 MirTarget;miRanda;miRNATAP -0.207032627562303 0.000345475920959793 NA NA NA hsa-miR-335-5p TNC -0.324086861750615 0.0899025346373434 1.46586319167032 4.78288244358886e-06 miRNAWalker2_validate;miRTarBase -0.357364309244245 3.51522313149958e-05 NA NA NA hsa-miR-425-5p TNC 0.85235119766839 8.55415485589217e-07 1.46586319167032 4.78288244358886e-06 MirTarget -0.332023437625411 0.000435819705330582 NA NA NA hsa-miR-486-5p TNC -3.31030668897609 1.04617579408648e-33 1.46586319167032 4.78288244358886e-06 PITA;miRanda -0.197955126672279 0.000327282047200235 NA NA NA hsa-miR-501-5p TNC 0.316742767698094 0.0632047358679198 1.46586319167032 4.78288244358886e-06 miRNATAP -0.353852733563241 0.000275855356730739 NA NA NA hsa-miR-590-3p TNC 0.9225805269779 6.0121446263776e-11 1.46586319167032 4.78288244358886e-06 miRanda -0.240063888308625 0.0379198084214256 NA NA NA hsa-miR-338-3p TNN -2.39495045399875 3.50911311863594e-28 -1.07826647434668 0.000305032327839066 miRanda -0.191485189974355 0.00345834112164486 NA NA NA hsa-miR-342-3p TNN 0.34628335679908 0.0121498405984511 -1.07826647434668 0.000305032327839066 miRanda -0.290720387108436 0.00932868534291326 NA NA NA hsa-miR-944 TNN 6.31318502943581 6.64615435406088e-56 -1.07826647434668 0.000305032327839066 miRNATAP -0.170383928557509 1.62151860496987e-07 NA NA NA hsa-miR-1301-3p TNXB 1.75268901788708 9.77575865554511e-22 -5.07951890932335 8.17535475669788e-53 miRNAWalker2_validate -0.814646498648356 6.19960796786608e-17 NA NA NA hsa-miR-3607-3p TNXB 0.797258097957342 0.000266170796527225 -5.07951890932335 8.17535475669788e-53 miRNATAP -0.198674802120141 0.0261249963226519 NA NA NA hsa-let-7a-5p TP53 -0.644221394537031 9.97672106245846e-14 0.426399740413351 0.03608790359392 TargetScan -0.442727786863099 0.000176139953176021 NA NA NA hsa-miR-221-3p TP53 -0.38281209626394 0.00382602010056484 0.426399740413351 0.03608790359392 miRNAWalker2_validate -0.233781376434455 0.00302305411505104 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-30d-5p TP53 -2.06908130936031 2.23574479943606e-47 0.426399740413351 0.03608790359392 miRNAWalker2_validate -0.245997943375811 0.000117727889022278 NA NA NA hsa-miR-338-3p TP53 -2.39495045399875 3.50911311863594e-28 0.426399740413351 0.03608790359392 miRanda -0.120118668335106 0.00679444118382355 NA NA NA hsa-miR-381-3p TP53 -0.169830967672372 0.407011050702885 0.426399740413351 0.03608790359392 MirTarget -0.109867442232664 0.0313328201012888 NA NA NA hsa-miR-1-3p VEGFA -2.66147018870582 3.25607598393088e-22 0.0913534585745772 0.564283046512495 MirTarget -0.103665039169292 0.000195148819864229 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-101-3p VEGFA -2.01992291103908 2.62945171087274e-42 0.0913534585745772 0.564283046512495 miRNAWalker2_validate -0.201641389242731 3.17700314330176e-05 NA NA NA hsa-miR-140-5p VEGFA -0.615965395622439 1.05820583250804e-08 0.0913534585745772 0.564283046512495 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.362898663148948 8.39754073046914e-07 26402430 MicroRNA 140 5p inhibits the progression of colorectal cancer by targeting VEGFA; The direct regulation of VEGFA by miR-140-5p was identified using luciferase reporter assay; Integrated analysis identified VEGFA as a direct and functional target gene of miR-140-5p; Silencing VEGFA by small interfering RNA siRNA resembled the phenotype resulting from ectopic miR-140-5p expression while overexpression of VEGFA attenuated the effect of miR-140-5p on CRC cells; Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA progression;tumorigenesis colorectal cancer hsa-miR-150-5p VEGFA -0.862350644813022 0.000126661451795198 0.0913534585745772 0.564283046512495 miRNAWalker2_validate;miRTarBase -0.216811219763087 5.36369817759154e-10 NA NA NA hsa-miR-29b-2-5p VEGFA -1.04734214410093 8.2886590108117e-14 0.0913534585745772 0.564283046512495 MirTarget -0.147999098529345 0.00819756957722119 NA NA NA hsa-miR-29c-3p VEGFA -1.50225173284958 1.90087771871443e-16 0.0913534585745772 0.564283046512495 miRNAWalker2_validate;MirTarget -0.159538795805995 0.000163986812603113 NA NA NA hsa-miR-497-5p VEGFA -1.37093122385312 2.06413037457593e-23 0.0913534585745772 0.564283046512495 MirTarget -0.11202010413458 0.0441625113185609 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-128-3p VEGFC 0.940275845868474 5.3111687457665e-10 -1.1733328546142 1.49901555881038e-07 miRNAWalker2_validate;MirTarget -0.588630285665444 4.25116667757601e-16 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-129-5p VEGFC 2.0409652261565 1.19491474689015e-07 -1.1733328546142 1.49901555881038e-07 miRanda -0.143987892921731 8.68862415501383e-07 NA NA NA hsa-miR-16-2-3p VEGFC 0.505774348451832 0.00083906759991608 -1.1733328546142 1.49901555881038e-07 MirTarget -0.538423475577415 4.41007501104168e-13 NA NA NA hsa-miR-27b-3p VEGFC 0.0774984459252845 0.455541249499373 -1.1733328546142 1.49901555881038e-07 MirTarget -0.622707556552546 2.4938323020219e-08 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-374a-5p VEGFC -0.371522195407694 3.64288279697975e-05 -1.1733328546142 1.49901555881038e-07 MirTarget -0.365176729055263 0.00504623064320774 NA NA NA hsa-miR-590-3p VEGFC 0.9225805269779 6.0121446263776e-11 -1.1733328546142 1.49901555881038e-07 miRanda -0.316528552702575 8.13915266905417e-05 NA NA NA hsa-miR-129-5p VWF 2.0409652261565 1.19491474689015e-07 -3.19786087054897 1.29873833870803e-49 miRanda -0.142148555099601 8.81208671982342e-06 NA NA NA hsa-miR-15b-5p VWF 0.575042920336974 9.75508983626876e-06 -3.19786087054897 1.29873833870803e-49 mirMAP -0.760523752969573 3.43456447700553e-16 NA NA NA hsa-miR-16-5p VWF 0.200674510503047 0.0593717079356147 -3.19786087054897 1.29873833870803e-49 mirMAP -0.428603338673368 0.00034923441487984 NA NA NA hsa-miR-424-5p VWF 1.50572404087407 4.24425395615445e-20 -3.19786087054897 1.29873833870803e-49 mirMAP -0.585001401271645 1.07117182266239e-16 NA NA NA hsa-miR-429 VWF 1.44127712764248 1.7824212712414e-11 -3.19786087054897 1.29873833870803e-49 miRNATAP -0.468696874433999 1.63490574874626e-17 NA NA NA hsa-miR-100-5p YWHAE -1.55858901419153 8.83648748818133e-17 0.203042603051275 0.0166251918717912 miRNAWalker2_validate -0.102375887861451 2.98300205516031e-06 NA NA NA hsa-miR-140-5p YWHAE -0.615965395622439 1.05820583250804e-08 0.203042603051275 0.0166251918717912 miRanda -0.171016618367424 1.50955190430988e-05 NA NA NA hsa-miR-146b-5p YWHAE -0.432155779449763 0.00591587599739451 0.203042603051275 0.0166251918717912 miRanda -0.111392910066599 4.69207946374759e-05 NA NA NA hsa-miR-199a-5p YWHAE 0.125189495212204 0.398433974759894 0.203042603051275 0.0166251918717912 miRanda -0.12014743712606 3.72014831205565e-05 NA NA NA hsa-miR-26a-5p YWHAE -0.929312251092796 7.48452512025337e-23 0.203042603051275 0.0166251918717912 miRNAWalker2_validate;miRNATAP -0.178807779458505 3.86448824279165e-05 NA NA NA hsa-miR-29b-2-5p YWHAE -1.04734214410093 8.2886590108117e-14 0.203042603051275 0.0166251918717912 MirTarget -0.149087541552757 4.56876887825692e-07 NA NA NA hsa-miR-139-5p YWHAG -2.25560964518719 9.95317711940085e-30 0.991040830472683 7.4365456540348e-22 MirTarget;PITA;miRanda;miRNATAP -0.194980667816077 5.53685952927741e-15 NA NA NA hsa-miR-140-3p YWHAG -1.5688188604984 7.06409475976727e-33 0.991040830472683 7.4365456540348e-22 MirTarget;PITA;miRNATAP -0.301567187617845 1.07601619800412e-15 NA NA NA hsa-miR-181a-5p YWHAG -1.31879909071317 2.04570351303734e-24 0.991040830472683 7.4365456540348e-22 MirTarget;miRNATAP -0.314225339521941 1.0053180668449e-15 NA NA NA hsa-miR-181b-5p YWHAG -0.578702702808657 2.41220004393722e-05 0.991040830472683 7.4365456540348e-22 MirTarget;miRNATAP -0.228892987445348 9.07011367799824e-09 27102539 miR 181b 3p promotes epithelial mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG breast cancer hsa-miR-181c-5p YWHAG -1.36921360773694 5.61046203952059e-19 0.991040830472683 7.4365456540348e-22 MirTarget;miRNATAP -0.22905644914337 1.12170184024473e-11 NA NA NA hsa-miR-217 YWHAG -0.501449190998853 0.0366805136279841 0.991040830472683 7.4365456540348e-22 MirTarget;PITA;miRanda;miRNATAP -0.119942832592694 1.57857495100735e-07 NA NA NA hsa-miR-30a-5p YWHAG -2.98793938555326 1.93840183838367e-49 0.991040830472683 7.4365456540348e-22 miRNATAP -0.227094539731202 1.45121165271543e-23 NA NA NA hsa-miR-30b-5p YWHAG -1.50117013761001 1.78247435398346e-20 0.991040830472683 7.4365456540348e-22 miRNATAP -0.16848409022323 1.82745456292842e-07 NA NA NA hsa-miR-30c-5p YWHAG -0.426804145561029 0.00403132854321475 0.991040830472683 7.4365456540348e-22 miRNATAP -0.183908565586177 7.45882294531463e-07 NA NA NA hsa-miR-30d-5p YWHAG -2.06908130936031 2.23574479943606e-47 0.991040830472683 7.4365456540348e-22 miRNATAP -0.253839886387983 2.18904430520727e-14 NA NA NA hsa-miR-30e-5p YWHAG 0.186424244301373 0.077486249643257 0.991040830472683 7.4365456540348e-22 miRNATAP -0.213367227578757 5.92684901167063e-05 NA NA NA hsa-miR-338-5p YWHAG -2.99778534642888 2.74111905046628e-39 0.991040830472683 7.4365456540348e-22 PITA;miRNATAP -0.168782716969438 1.94636488452499e-15 NA NA NA hsa-miR-342-3p YWHAG 0.34628335679908 0.0121498405984511 0.991040830472683 7.4365456540348e-22 miRanda -0.130792992379678 0.00121155781811771 NA NA NA hsa-miR-361-3p YWHAG -0.491157107537441 1.38504517485595e-06 0.991040830472683 7.4365456540348e-22 miRNATAP -0.39507282701589 9.98398887494058e-14 NA NA NA hsa-miR-103a-3p YWHAH 0.227460152182967 0.0312044839849861 -0.252634869802371 0.000760648963297126 miRNAWalker2_validate;MirTarget;miRNATAP -0.133981746212253 0.00024844262206068 NA NA NA hsa-miR-186-5p YWHAH 0.439819047090102 6.33375570167175e-05 -0.252634869802371 0.000760648963297126 miRNAWalker2_validate -0.143869180396051 3.4088957276727e-05 NA NA NA hsa-miR-1-3p YWHAQ -2.66147018870582 3.25607598393088e-22 0.758136538598598 1.50949450950029e-15 MirTarget -0.105822771784681 5.60928859053694e-10 NA NA NA hsa-miR-139-5p YWHAQ -2.25560964518719 9.95317711940085e-30 0.758136538598598 1.50949450950029e-15 MirTarget;PITA;miRanda;miRNATAP -0.159648129026272 2.15693088716811e-12 NA NA NA hsa-miR-140-5p YWHAQ -0.615965395622439 1.05820583250804e-08 0.758136538598598 1.50949450950029e-15 miRanda -0.192120061435239 3.10498932840056e-05 NA NA NA hsa-miR-145-3p YWHAQ -1.41475926107847 2.20187227373045e-21 0.758136538598598 1.50949450950029e-15 MirTarget;miRNATAP -0.166975335943194 1.33513123820668e-07 NA NA NA hsa-miR-15a-5p YWHAQ -0.24629041301676 0.0253630661893983 0.758136538598598 1.50949450950029e-15 MirTarget;miRNATAP -0.151622034984301 0.00100156671385193 NA NA NA hsa-miR-195-5p YWHAQ -1.62452829530841 2.94084397454942e-29 0.758136538598598 1.50949450950029e-15 MirTarget;miRNATAP -0.178581848866332 1.9825890568546e-08 NA NA NA hsa-miR-497-5p YWHAQ -1.37093122385312 2.06413037457593e-23 0.758136538598598 1.50949450950029e-15 MirTarget;miRNATAP -0.15624886516024 5.25650115984208e-06 NA NA NA hsa-let-7b-5p YWHAZ -0.759197439090238 1.31014217546415e-10 1.17463375159892 1.02187598388775e-30 miRNAWalker2_validate -0.16953431209772 0.000298312090690078 NA NA NA hsa-miR-1-3p YWHAZ -2.66147018870582 3.25607598393088e-22 1.17463375159892 1.02187598388775e-30 MirTarget -0.129382289224496 1.08362692441971e-11 NA NA NA hsa-miR-125a-5p YWHAZ -0.463931772449969 8.22426972811352e-05 1.17463375159892 1.02187598388775e-30 miRanda -0.264188064064187 2.25493898945633e-08 NA NA NA hsa-miR-140-3p YWHAZ -1.5688188604984 7.06409475976727e-33 1.17463375159892 1.02187598388775e-30 MirTarget;PITA;miRNATAP -0.320089357215389 3.40777505730482e-17 NA NA NA hsa-miR-195-3p YWHAZ -1.41416709285168 7.64629179830096e-19 1.17463375159892 1.02187598388775e-30 MirTarget -0.251167746397152 1.59786447478398e-14 NA NA NA hsa-miR-30a-5p YWHAZ -2.98793938555326 1.93840183838367e-49 1.17463375159892 1.02187598388775e-30 miRNAWalker2_validate;MirTarget;miRNATAP -0.259196367585634 1.43103925181126e-30 NA NA NA hsa-miR-30b-5p YWHAZ -1.50117013761001 1.78247435398346e-20 1.17463375159892 1.02187598388775e-30 MirTarget;miRNATAP -0.149634843805737 5.35813092161747e-06 NA NA NA hsa-miR-30c-5p YWHAZ -0.426804145561029 0.00403132854321475 1.17463375159892 1.02187598388775e-30 MirTarget;miRNATAP -0.178743732372389 2.15370337636889e-06 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30d-5p YWHAZ -2.06908130936031 2.23574479943606e-47 1.17463375159892 1.02187598388775e-30 MirTarget;miRNATAP -0.292555182303525 1.48341760672661e-18 NA NA NA hsa-miR-30e-5p YWHAZ 0.186424244301373 0.077486249643257 1.17463375159892 1.02187598388775e-30 MirTarget;miRNATAP -0.146381808100747 0.00689521054840556 NA NA NA hsa-miR-338-5p YWHAZ -2.99778534642888 2.74111905046628e-39 1.17463375159892 1.02187598388775e-30 mirMAP -0.177431358614088 1.38329523339697e-16 NA NA NA hsa-miR-374a-3p YWHAZ -0.104091172625131 0.359725600505889 1.17463375159892 1.02187598388775e-30 mirMAP -0.131456990352814 0.00898397838864041 NA NA NA hsa-miR-3913-5p YWHAZ -0.204552406283694 0.152259141583586 1.17463375159892 1.02187598388775e-30 MirTarget -0.107390909288523 0.00726413953939948 NA NA NA hsa-miR-451a YWHAZ -3.19333121412162 5.29546274008147e-27 1.17463375159892 1.02187598388775e-30 MirTarget;miRNATAP -0.101302210027792 5.53172435922016e-09 26885274 miR 451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer; In this study expressions of miR-451 and Ywhaz in CRC tissues and adjacent normal tissues were detected by quantitative real-time PCR qRT-PCR and immunohistochemistry respectively; Ywhaz-3'UTR luciferase reporter assay confirmed Ywhaz as a direct target gene of miR-451; miR-451 may inhibit the colon cancer growth in vitro and in vivo likely through directly targeting Ywhaz and indirectly regulating the nuclear accumulation of FoxO3 colorectal cancer