miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7c-5p ACTB -2.07953368242668 3.46048888391218e-23 0.18640824576565 0.030171008208517 miRNAWalker2_validate -0.110330162858087 4.58289213871066e-11 NA NA NA hsa-miR-378a-3p ACTB -1.50453783521372 9.41694954361173e-17 0.18640824576565 0.030171008208517 miRNAWalker2_validate -0.129510273286437 4.84232178165314e-11 NA NA NA hsa-miR-107 ACTG1 -0.0447040564279497 0.671618791096755 -0.140975281588258 0.0941742387812935 miRanda;miRNATAP -0.141107853737113 5.22192194887629e-05 NA NA NA hsa-miR-652-3p ACTG1 0.358960167804889 0.00317496895411853 -0.140975281588258 0.0941742387812935 miRNAWalker2_validate -0.101012561529842 0.000788636404281757 NA NA NA hsa-let-7a-3p AMOT 0.0966652362351867 0.423761916840503 -3.27115544684498 1.6043339007473e-20 mirMAP -0.642540236996422 1.1415304766014e-06 NA NA NA hsa-let-7f-1-3p AMOT 0.700374242293247 8.65000484720084e-08 -3.27115544684498 1.6043339007473e-20 mirMAP -0.481962215736466 6.46239966284493e-05 NA NA NA hsa-miR-16-1-3p AMOT 0.955017760172879 5.95379292601146e-11 -3.27115544684498 1.6043339007473e-20 mirMAP -0.573647506216094 7.92255181822464e-08 NA NA NA hsa-miR-203a-3p AMOT 0.0441399794719697 0.880456392176704 -3.27115544684498 1.6043339007473e-20 MirTarget -0.350788075720036 5.48836267593792e-11 NA NA NA hsa-miR-205-5p AMOT 1.50759485376634 2.0003886738248e-16 -3.27115544684498 1.6043339007473e-20 MirTarget;miRNATAP -0.774216168819107 1.67825992807398e-21 26239614 MicroRNA 205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression; In the present study miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region 3'-UTR of AMOT in breast cancer MCF-7 cells by luciferase assay; miR-205 and small interfering RNA siRNA-mediated AMOT-knockdown experiments revealed that miR-205 significantly inhibited the proliferation and the invasion of MCF-7 cells through a decrease in the expression of AMOT yet had no effect on apoptosis; Furthermore we observed that the overexpression of AMOT partially reversed the inhibitory effect of miR-205 on the growth and the invasion of MCF-7 cells; The data indicated that miR-205 regulated the proliferation and the invasion of breast cancer cells through suppression of AMOT expression at least partly; Therefore the disordered decreased expression of miR-205 and the resulting AMOT upregulation contributes to breast carcinogenesis and miR-205-AMOT represents a new potential therapeutic target for the treatment of breast carcinoma tumorigenesis breast cancer hsa-miR-21-3p AMOT 1.25126438776674 2.4124216716282e-17 -3.27115544684498 1.6043339007473e-20 mirMAP -1.00120188434014 2.30186115098482e-23 NA NA NA hsa-miR-221-3p AMOT 0.410625614724387 0.000741090075261272 -3.27115544684498 1.6043339007473e-20 miRNAWalker2_validate -0.735705711370012 1.4869564768487e-08 NA NA NA hsa-miR-2355-3p AMOT 1.58434563546762 4.06578912176206e-18 -3.27115544684498 1.6043339007473e-20 MirTarget;miRNATAP -0.857674067703419 1.64453895362754e-26 NA NA NA hsa-miR-330-5p AMOT 0.944693925383906 5.04972895657346e-13 -3.27115544684498 1.6043339007473e-20 miRanda -0.553843824327258 3.27211443102715e-06 NA NA NA hsa-miR-342-3p AMOT 0.99756868977753 9.28499866272332e-10 -3.27115544684498 1.6043339007473e-20 miRanda -0.273526049190747 0.00461504168373576 NA NA NA hsa-miR-450b-5p AMOT 1.25529820885833 1.18847120528666e-15 -3.27115544684498 1.6043339007473e-20 mirMAP -0.393998885759583 6.63410826786205e-05 NA NA NA hsa-miR-576-5p AMOT 0.940432050128373 6.90227595663302e-12 -3.27115544684498 1.6043339007473e-20 mirMAP -0.892193470646945 1.21541891214623e-15 NA NA NA hsa-miR-627-5p AMOT 0.352962182324836 0.0471199545348354 -3.27115544684498 1.6043339007473e-20 MirTarget -0.241941788679368 0.00921915720540382 NA NA NA hsa-miR-629-3p AMOT 1.43262037314105 2.37092217984413e-19 -3.27115544684498 1.6043339007473e-20 MirTarget -0.490373350101366 3.33791766252739e-07 NA NA NA hsa-miR-7-1-3p AMOT 1.13646121619622 1.49823237535933e-14 -3.27115544684498 1.6043339007473e-20 MirTarget;mirMAP -0.508385868811851 1.19813023235533e-06 NA NA NA hsa-miR-766-3p AMOT 1.07002176594541 8.2375790648059e-16 -3.27115544684498 1.6043339007473e-20 MirTarget -0.345781120324013 0.00315163504572844 NA NA NA hsa-miR-944 AMOT 1.47323925060177 2.61626403984929e-13 -3.27115544684498 1.6043339007473e-20 mirMAP;miRNATAP -0.567595741562712 6.22112458644627e-14 NA NA NA hsa-let-7a-3p APC 0.0966652362351867 0.423761916840503 -0.546284851471097 3.40552793858261e-06 mirMAP -0.184630001240554 1.60274842027997e-05 NA NA NA hsa-miR-125a-5p APC 0.215366061934933 0.119550904549401 -0.546284851471097 3.40552793858261e-06 miRanda -0.241642305543728 5.41842025946961e-11 NA NA NA hsa-miR-135b-5p APC 1.5570143078477 4.60753610971455e-13 -0.546284851471097 3.40552793858261e-06 miRTarBase;MirTarget -0.101442831003325 1.35019474063077e-05 24735923;18632633;23328512 We show that miR-135b overexpression is triggered in mice and humans by APC loss PTEN/PI3K pathway deregulation and SRC overexpression and promotes tumor transformation and progression;Regulation of the adenomatous polyposis coli gene by the miR 135 family in colorectal cancer;Real-time quantitative PCR and Western blot were used to explore the relationship between miR-135b and adenomatous polyposis coli APC; MiR-135b promoted gastric cancer cell proliferation inhibited its apoptosis and directly regulated the expression of APC in gastric cancer cell progression;; colon cancer;colorectal cancer;gastric cancer hsa-miR-182-5p APC 1.15060905311096 6.25565852529946e-10 -0.546284851471097 3.40552793858261e-06 MirTarget -0.105150505355621 0.000111476597787192 NA NA NA hsa-miR-186-5p APC 0.353452958261612 0.000145058448579496 -0.546284851471097 3.40552793858261e-06 miRNAWalker2_validate -0.292964288394194 1.18140584181448e-07 NA NA NA hsa-miR-193a-3p APC 0.22120710726779 0.111827069464729 -0.546284851471097 3.40552793858261e-06 miRanda -0.160350465730158 1.51155317135791e-05 NA NA NA hsa-miR-21-5p APC 1.62465922021121 3.44191300985109e-58 -0.546284851471097 3.40552793858261e-06 miRNAWalker2_validate -0.278906111202813 6.58270059300518e-10 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-320a APC 0.801356001806321 4.91397101474502e-09 -0.546284851471097 3.40552793858261e-06 miRanda -0.168627634511469 5.31081768756284e-06 NA NA NA hsa-miR-338-3p APC -0.948755228846395 8.99167125682392e-08 -0.546284851471097 3.40552793858261e-06 miRanda -0.157975637349898 2.82707855206972e-08 NA NA NA hsa-miR-374b-5p APC -0.288413933608091 0.0041474558664058 -0.546284851471097 3.40552793858261e-06 mirMAP -0.26053225009571 3.69272696325675e-07 NA NA NA hsa-miR-450b-5p APC 1.25529820885833 1.18847120528666e-15 -0.546284851471097 3.40552793858261e-06 miRNATAP -0.182543010743283 8.21856445012781e-09 NA NA NA hsa-miR-501-3p APC 0.820141346319976 1.74562930463389e-08 -0.546284851471097 3.40552793858261e-06 TargetScan -0.238301982455388 4.74874004351065e-12 NA NA NA hsa-miR-589-3p APC 1.59559692667315 6.2886410639161e-15 -0.546284851471097 3.40552793858261e-06 MirTarget -0.149191828445292 3.49922336833374e-09 NA NA NA hsa-miR-655-3p APC -1.15004187025356 3.60771552708797e-07 -0.546284851471097 3.40552793858261e-06 MirTarget -0.106271133656611 5.01589000788752e-06 NA NA NA hsa-let-7a-5p APC2 -0.439381775414001 3.1119785480023e-05 1.40015307909901 8.15847629068564e-08 TargetScan -0.375729293479308 0.000576259176502018 NA NA NA hsa-miR-107 AREG -0.0447040564279497 0.671618791096755 0.418478955882987 0.221785826717941 miRanda -0.614866971292197 1.52185825241937e-05 NA NA NA hsa-miR-129-5p AREG -0.246329588499478 0.436451191224681 0.418478955882987 0.221785826717941 miRanda -0.134467655864913 0.00495139961450085 NA NA NA hsa-miR-217 AREG -1.35391381055929 2.42394951427902e-09 0.418478955882987 0.221785826717941 miRanda -0.232960701833644 0.000306828711226382 NA NA NA hsa-miR-326 AREG -0.425943992128769 0.0415010315530797 0.418478955882987 0.221785826717941 miRanda -0.259711813737398 0.000278969391218594 NA NA NA hsa-miR-335-5p AREG -1.17227779671552 1.49282618530733e-10 0.418478955882987 0.221785826717941 miRNAWalker2_validate -0.414177610610323 1.82148425773746e-07 NA NA NA hsa-let-7a-3p AXIN2 0.0966652362351867 0.423761916840503 -0.654821030558051 0.00118287348398744 miRNATAP -0.35376916882209 1.26715453790834e-06 NA NA NA hsa-miR-103a-3p AXIN2 0.556219385347418 1.55815736455067e-09 -0.654821030558051 0.00118287348398744 miRNAWalker2_validate;MirTarget;miRNATAP -0.325903741654877 0.000625647322873736 NA NA NA hsa-miR-15a-5p AXIN2 0.783550182002274 2.60699595655907e-11 -0.654821030558051 0.00118287348398744 MirTarget;miRNATAP -0.566286065147261 4.5935887109618e-15 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.85315666454713 3.79816274836297e-12 -0.654821030558051 0.00118287348398744 miRTarBase;MirTarget;miRNATAP -0.35176986456837 5.28324433930037e-07 NA NA NA hsa-miR-16-2-3p AXIN2 1.1567130855258 1.01867256952189e-14 -0.654821030558051 0.00118287348398744 mirMAP -0.49217605818279 1.0755436174937e-18 NA NA NA hsa-miR-16-5p AXIN2 0.521122945828175 1.40561786410572e-06 -0.654821030558051 0.00118287348398744 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.516355909847163 1.27186039574774e-10 NA NA NA hsa-miR-205-5p AXIN2 1.50759485376634 2.0003886738248e-16 -0.654821030558051 0.00118287348398744 miRNATAP -0.402750057470777 4.93978195907313e-19 NA NA NA hsa-miR-221-3p AXIN2 0.410625614724387 0.000741090075261272 -0.654821030558051 0.00118287348398744 miRNATAP -0.378135141136746 1.49289375810213e-07 NA NA NA hsa-miR-222-3p AXIN2 1.08197052578759 2.32604040301699e-14 -0.654821030558051 0.00118287348398744 miRNATAP -0.45306601410317 2.45775781095599e-14 NA NA NA hsa-miR-26b-3p AXIN2 0.421575313079363 0.00223298166810883 -0.654821030558051 0.00118287348398744 MirTarget -0.19562586059829 0.00224752439273587 NA NA NA hsa-miR-29a-5p AXIN2 0.323252792625584 0.0370417231222825 -0.654821030558051 0.00118287348398744 MirTarget -0.257731959114779 5.48140564378954e-06 NA NA NA hsa-miR-34a-5p AXIN2 -0.117372471043915 0.364001947180738 -0.654821030558051 0.00118287348398744 miRNAWalker2_validate;miRTarBase -0.183241700018222 0.00764423689823707 23624843 p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients colorectal cancer hsa-miR-3614-5p AXIN2 0.955957969488529 2.95347675446694e-05 -0.654821030558051 0.00118287348398744 MirTarget;miRNATAP -0.18570721643536 1.0495845040705e-06 NA NA NA hsa-miR-429 AXIN2 0.559451508722375 0.00563641638673083 -0.654821030558051 0.00118287348398744 miRanda -0.164290793062077 0.000156578616889057 NA NA NA hsa-miR-582-5p AXIN2 -0.0366995972742474 0.821827119138923 -0.654821030558051 0.00118287348398744 miRNATAP -0.268939077482895 6.0756995308908e-07 NA NA NA hsa-miR-590-3p AXIN2 0.221436901462551 0.0965904764063157 -0.654821030558051 0.00118287348398744 MirTarget;PITA;miRanda;miRNATAP -0.271329539298903 4.21494610216448e-05 NA NA NA hsa-miR-944 AXIN2 1.47323925060177 2.61626403984929e-13 -0.654821030558051 0.00118287348398744 MirTarget;PITA;miRNATAP -0.182407888375862 1.83781560784638e-05 NA NA NA hsa-miR-139-5p BBC3 -1.46099200329485 7.85040381494472e-22 0.908969832434519 2.81890699384748e-10 miRNATAP -0.219713232841052 3.65461069729995e-08 NA NA NA hsa-miR-144-3p BBC3 -1.64994343636831 1.13169944841075e-08 0.908969832434519 2.81890699384748e-10 miRNATAP -0.105802966202106 9.49962606775774e-07 NA NA NA hsa-miR-24-3p BBC3 0.13115428390042 0.203891651275156 0.908969832434519 2.81890699384748e-10 miRNATAP -0.230932302847746 0.000208687707166106 NA NA NA hsa-let-7b-5p BIRC5 -0.2489842756826 0.0211384499461719 2.16131340080092 1.08988011844515e-40 miRNAWalker2_validate -0.313223606603795 9.94342274798167e-06 NA NA NA hsa-miR-101-3p BIRC5 -1.91263766544878 1.50270129259053e-39 2.16131340080092 1.08988011844515e-40 miRNAWalker2_validate -0.430522524036711 5.40972663502639e-20 NA NA NA hsa-miR-218-5p BIRC5 -1.0725338636959 3.61493686604269e-09 2.16131340080092 1.08988011844515e-40 miRTarBase;MirTarget -0.111470306073746 0.00720468469257464 25473903;25900794;26442524 Survivin BIRC5 was subsequently identified as an important cervical cancer target of miR-218 using in silico prediction mRNA profiling and quantitative real-time PCR qRT-PCR;miR-218 binds survivin BIRC5 mRNA 3'-UTR and down-regulated reporter luciferase activity;MiR-218 promoted apoptosis inhibited cell proliferation and caused cell cycle arrest in CRC cells by suppressing BIRC5 expression; In conclusion we demonstrated that high miR-218 expression had a positive prognostic value in 5-FU-based treatments for CRC patients and discovered a novel mechanism mediated by miR-218 to promote apoptosis and to function synergistically with 5-FU to promote chemosensitivity by suppressing BIRC5 and TS in CRC ;; cervical and endocervical cancer;breast cancer;colorectal cancer hsa-miR-335-5p BIRC5 -1.17227779671552 1.49282618530733e-10 2.16131340080092 1.08988011844515e-40 miRNAWalker2_validate;MirTarget -0.132634350520529 0.00122150706387881 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-375 BIRC5 -4.24070205340868 7.48368361454041e-28 2.16131340080092 1.08988011844515e-40 miRanda -0.129259602498008 1.49050783269355e-12 NA NA NA hsa-miR-106b-5p BMP2 0.50378717276868 1.45412404526866e-05 0.810943012235995 0.000400846574506627 miRNATAP -0.341022043034271 7.17010555502952e-05 NA NA NA hsa-miR-335-3p BMP2 0.336785882180547 0.0542446207938138 0.810943012235995 0.000400846574506627 mirMAP -0.305108734888186 7.77808291656295e-08 NA NA NA hsa-miR-335-5p BMP2 -1.17227779671552 1.49282618530733e-10 0.810943012235995 0.000400846574506627 miRNAWalker2_validate -0.362487274034449 7.09664057344423e-12 NA NA NA hsa-miR-374b-5p BMP2 -0.288413933608091 0.0041474558664058 0.810943012235995 0.000400846574506627 miRNATAP -0.419997341629046 2.6375549374501e-05 NA NA NA hsa-miR-378c BMP2 -1.82618708894602 7.26454201089171e-22 0.810943012235995 0.000400846574506627 miRNATAP -0.213425979987274 2.27749353721347e-05 NA NA NA hsa-miR-429 BMP2 0.559451508722375 0.00563641638673083 0.810943012235995 0.000400846574506627 miRNATAP -0.294389397581455 1.67859900798942e-09 NA NA NA hsa-miR-142-3p BMP4 1.12754191614028 1.68798138028946e-08 -1.05113180727339 1.41857411615692e-07 PITA;miRanda -0.157513477918801 0.000279342092958485 NA NA NA hsa-miR-130a-3p BMP6 0.67051191119964 4.89747518735144e-06 -0.24524233163941 0.21346923941731 MirTarget -0.301856899227049 1.61131708714617e-07 NA NA NA hsa-miR-301a-3p BMP6 2.14132004241926 4.46255413526808e-25 -0.24524233163941 0.21346923941731 MirTarget -0.187959498015097 1.62708723391956e-06 NA NA NA hsa-miR-320a BMP6 0.801356001806321 4.91397101474502e-09 -0.24524233163941 0.21346923941731 PITA;miRanda -0.218981845047652 0.000396781372704361 NA NA NA hsa-miR-320b BMP6 1.23473838180754 3.04337566045537e-14 -0.24524233163941 0.21346923941731 PITA;miRanda -0.191573713836897 0.000193303731173601 NA NA NA hsa-miR-454-3p BMP6 1.54137391927201 4.15861570449376e-20 -0.24524233163941 0.21346923941731 MirTarget -0.242424711959545 7.11130201427462e-07 NA NA NA hsa-miR-590-5p BMP6 0.763025362395968 3.65305892505623e-09 -0.24524233163941 0.21346923941731 miRanda -0.228032052044176 0.000500812752708257 NA NA NA hsa-miR-125a-3p BMP7 0.116035800853173 0.444825559956959 -0.207788367163592 0.492085317732896 miRanda -0.409523894672556 2.14777258614626e-06 NA NA NA hsa-miR-338-3p BMP7 -0.948755228846395 8.99167125682392e-08 -0.207788367163592 0.492085317732896 miRanda -0.211467661617769 0.00394110597349671 NA NA NA hsa-miR-455-5p BMP7 1.408595672323 5.52039116456697e-22 -0.207788367163592 0.492085317732896 miRanda -0.33728890935597 9.29053266616403e-05 NA NA NA hsa-miR-495-3p BMP7 -1.47803501311999 6.88839745293927e-13 -0.207788367163592 0.492085317732896 MirTarget -0.166112298507617 0.00810119906571452 NA NA NA hsa-miR-542-3p BMP7 0.643308814904977 8.81635403230104e-07 -0.207788367163592 0.492085317732896 miRanda;miRNATAP -0.314439291511803 0.00165689155888249 NA NA NA hsa-miR-30a-3p BMP8A -2.26144364746452 8.12421214153823e-31 2.58532886341501 2.91795841745819e-34 MirTarget -0.161756821506433 0.000639573087059676 NA NA NA hsa-miR-30b-3p BMP8A -0.338530747940815 0.0223424741180399 2.58532886341501 2.91795841745819e-34 MirTarget -0.209655001171356 0.0017147689992054 NA NA NA hsa-miR-30d-3p BMP8A -0.577371911152798 2.02950840095287e-06 2.58532886341501 2.91795841745819e-34 MirTarget -0.395949968512556 8.77571589468556e-07 NA NA NA hsa-miR-30e-3p BMP8A -0.890635378639789 1.65740480611339e-16 2.58532886341501 2.91795841745819e-34 MirTarget -0.441696866545303 6.27126875741745e-07 NA NA NA hsa-miR-125a-5p BMP8B 0.215366061934933 0.119550904549401 0.906982081381451 4.4937413556876e-05 miRanda -0.238284406576142 0.000740348362806314 NA NA NA hsa-miR-17-5p BMP8B 1.41924888736771 2.75805544953758e-18 0.906982081381451 4.4937413556876e-05 MirTarget -0.163547037898891 0.00478414162654776 NA NA NA hsa-miR-20a-5p BMP8B 1.1531986665452 1.02385132917958e-11 0.906982081381451 4.4937413556876e-05 MirTarget -0.21831053161733 0.000103268118391715 NA NA NA hsa-miR-2355-5p BMP8B 1.47205546931107 8.65192179636668e-19 0.906982081381451 4.4937413556876e-05 mirMAP -0.202465219348098 0.000340947270609721 NA NA NA hsa-miR-26b-5p BMP8B -0.254478038884324 0.0285227763044636 0.906982081381451 4.4937413556876e-05 miRNAWalker2_validate -0.332576238225389 7.59902203404529e-05 NA NA NA hsa-miR-362-5p BMP8B 0.41089772861323 0.0404254902071382 0.906982081381451 4.4937413556876e-05 mirMAP -0.248843557946637 2.38456971582627e-07 NA NA NA hsa-miR-455-5p BMP8B 1.408595672323 5.52039116456697e-22 0.906982081381451 4.4937413556876e-05 miRanda -0.299983155988423 2.46964367756979e-06 NA NA NA hsa-miR-186-5p BMPR1A 0.353452958261612 0.000145058448579496 -0.413899635623062 3.75393866512538e-05 MirTarget -0.140540541882308 0.00310036497333197 NA NA NA hsa-miR-320a BMPR1A 0.801356001806321 4.91397101474502e-09 -0.413899635623062 3.75393866512538e-05 MirTarget;PITA;miRanda -0.113251503001111 0.000345999319277011 NA NA NA hsa-miR-101-3p BMPR1B -1.91263766544878 1.50270129259053e-39 1.01488295220962 0.00105915156357881 miRNATAP -0.440642769134562 2.70425206598381e-07 NA NA NA hsa-miR-125b-5p BMPR1B -0.993460109818276 5.07736727659894e-12 1.01488295220962 0.00105915156357881 miRNAWalker2_validate;miRTarBase;MirTarget -0.329394047602336 0.000359587882194252 19738052;21556765 A risk variant in an miR 125b binding site in BMPR1B is associated with breast cancer pathogenesis; Furthermore luciferase reporter assays and overexpression of miR-125b-mimics combined with quantitative reverse transcription-PCR showed that BMPR1B transcript is a direct target of miR-125b and that miR-125b differentially regulates the C and T alleles of rs1434536; These results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk;Our findings show that rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged>70 years ; breast cancer;prostate cancer hsa-miR-142-5p BMPR1B 0.288897753038094 0.0900009317815725 1.01488295220962 0.00105915156357881 mirMAP -0.221971170673042 0.00534556939361919 NA NA NA hsa-miR-150-5p BMPR1B -0.243749814009231 0.331546276920338 1.01488295220962 0.00105915156357881 MirTarget -0.207910314280683 0.000112322146332479 NA NA NA hsa-miR-16-2-3p BMPR1B 1.1567130855258 1.01867256952189e-14 1.01488295220962 0.00105915156357881 mirMAP -0.391683818820269 8.57913176574759e-06 NA NA NA hsa-miR-23b-3p BMPR1B -0.497563803223134 3.31483353357535e-05 1.01488295220962 0.00105915156357881 mirMAP -0.375010246157336 0.000888927611112168 NA NA NA hsa-miR-26a-5p BMPR1B -1.09269574587169 1.24020612216319e-22 1.01488295220962 0.00105915156357881 mirMAP -0.337434461387968 0.0039457462212085 NA NA NA hsa-miR-374a-5p BMPR1B -0.621903385111545 6.61791773205282e-12 1.01488295220962 0.00105915156357881 MirTarget -0.517083681999763 0.000480338364597283 NA NA NA hsa-miR-374b-5p BMPR1B -0.288413933608091 0.0041474558664058 1.01488295220962 0.00105915156357881 MirTarget -0.42850687625758 0.00157863631981705 NA NA NA hsa-miR-429 BMPR1B 0.559451508722375 0.00563641638673083 1.01488295220962 0.00105915156357881 miRNATAP -0.27963972407448 2.71218971668372e-05 NA NA NA hsa-miR-629-3p BMPR1B 1.43262037314105 2.37092217984413e-19 1.01488295220962 0.00105915156357881 MirTarget -0.229142102216126 0.00536863957331594 NA NA NA hsa-let-7a-3p BMPR2 0.0966652362351867 0.423761916840503 -0.139496205223087 0.184586690531987 MirTarget;miRNATAP -0.205885268216014 4.6360936731726e-08 NA NA NA hsa-miR-103a-2-5p BMPR2 1.37988337975616 6.74852943995612e-08 -0.139496205223087 0.184586690531987 MirTarget -0.169689177677926 5.98219203837604e-20 NA NA NA hsa-miR-106a-5p BMPR2 0.67978010057847 0.00221925869726092 -0.139496205223087 0.184586690531987 MirTarget;miRNATAP -0.119173699033722 3.84511771824707e-09 NA NA NA hsa-miR-106b-5p BMPR2 0.50378717276868 1.45412404526866e-05 -0.139496205223087 0.184586690531987 MirTarget;miRNATAP -0.160236711128291 4.18638873569064e-05 NA NA NA hsa-miR-125a-5p BMPR2 0.215366061934933 0.119550904549401 -0.139496205223087 0.184586690531987 PITA -0.129845420545286 8.48113449984633e-05 NA NA NA hsa-miR-130a-3p BMPR2 0.67051191119964 4.89747518735144e-06 -0.139496205223087 0.184586690531987 miRNAWalker2_validate;MirTarget;miRNATAP -0.212251262751954 2.74469520988122e-12 NA NA NA hsa-miR-16-2-3p BMPR2 1.1567130855258 1.01867256952189e-14 -0.139496205223087 0.184586690531987 mirMAP -0.271849863711315 2.72342234658819e-21 NA NA NA hsa-miR-17-5p BMPR2 1.41924888736771 2.75805544953758e-18 -0.139496205223087 0.184586690531987 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.253417183596597 2.61439431029715e-22 NA NA NA hsa-miR-182-5p BMPR2 1.15060905311096 6.25565852529946e-10 -0.139496205223087 0.184586690531987 mirMAP -0.129128374264019 6.7376256848186e-08 NA NA NA hsa-miR-186-5p BMPR2 0.353452958261612 0.000145058448579496 -0.139496205223087 0.184586690531987 mirMAP -0.312414382221671 1.34869776086861e-10 NA NA NA hsa-miR-19a-3p BMPR2 1.35800152353624 2.80940447111944e-12 -0.139496205223087 0.184586690531987 miRNAWalker2_validate;MirTarget;miRNATAP -0.24668470648216 7.85910324765296e-30 NA NA NA hsa-miR-19b-3p BMPR2 0.538732279378089 0.000622008277870679 -0.139496205223087 0.184586690531987 miRNAWalker2_validate;MirTarget;miRNATAP -0.322798608519261 1.90675388559983e-32 NA NA NA hsa-miR-200b-3p BMPR2 0.0717138787925347 0.682858087587209 -0.139496205223087 0.184586690531987 mirMAP -0.165336622072794 1.21158060394017e-10 NA NA NA hsa-miR-200c-3p BMPR2 0.630251054099546 0.000131975031451555 -0.139496205223087 0.184586690531987 mirMAP -0.10885676203804 7.56311630398089e-05 NA NA NA hsa-miR-205-3p BMPR2 1.2960640797621 5.80786479909147e-11 -0.139496205223087 0.184586690531987 mirMAP -0.105393014226008 2.83424172417428e-06 NA NA NA hsa-miR-205-5p BMPR2 1.50759485376634 2.0003886738248e-16 -0.139496205223087 0.184586690531987 mirMAP -0.154884666002013 7.56118077061912e-11 NA NA NA hsa-miR-20a-5p BMPR2 1.1531986665452 1.02385132917958e-11 -0.139496205223087 0.184586690531987 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.270008218927596 6.64893492881106e-27 NA NA NA hsa-miR-20b-5p BMPR2 0.345967670847176 0.232014828043601 -0.139496205223087 0.184586690531987 MirTarget;miRNATAP -0.104111647467311 1.92409736196742e-11 NA NA NA hsa-miR-25-3p BMPR2 0.76549796417801 3.32282098247097e-11 -0.139496205223087 0.184586690531987 miRNATAP -0.297218979179475 6.15346387784816e-15 NA NA NA hsa-miR-26a-2-3p BMPR2 -0.444498687388748 0.00325793861409413 -0.139496205223087 0.184586690531987 mirMAP -0.174260487981316 5.5945191400279e-09 NA NA NA hsa-miR-26b-5p BMPR2 -0.254478038884324 0.0285227763044636 -0.139496205223087 0.184586690531987 miRNAWalker2_validate -0.242996724381737 4.47840441038487e-10 NA NA NA hsa-miR-28-3p BMPR2 0.459875450032895 3.47095927872566e-07 -0.139496205223087 0.184586690531987 mirMAP -0.160385671380115 0.00154772002938174 NA NA NA hsa-miR-29a-5p BMPR2 0.323252792625584 0.0370417231222825 -0.139496205223087 0.184586690531987 mirMAP -0.179325660454421 7.20584109281264e-10 NA NA NA hsa-miR-301a-3p BMPR2 2.14132004241926 4.46255413526808e-25 -0.139496205223087 0.184586690531987 MirTarget;miRNATAP -0.166733056981384 3.48736355737059e-16 NA NA NA hsa-miR-30b-5p BMPR2 -0.400238605368173 0.00346540992719245 -0.139496205223087 0.184586690531987 mirMAP -0.284270175988839 1.45724321832615e-18 NA NA NA hsa-miR-30c-5p BMPR2 0.021222006155897 0.886366656528128 -0.139496205223087 0.184586690531987 mirMAP -0.279213889893375 6.24444769032606e-21 NA NA NA hsa-miR-30e-5p BMPR2 -1.02114836019762 6.81961221797866e-17 -0.139496205223087 0.184586690531987 mirMAP -0.102752241281789 0.00475281750134937 NA NA NA hsa-miR-32-5p BMPR2 -0.317310201890053 0.0102525324475293 -0.139496205223087 0.184586690531987 miRNATAP -0.166021827113726 6.75396218626017e-06 NA NA NA hsa-miR-320a BMPR2 0.801356001806321 4.91397101474502e-09 -0.139496205223087 0.184586690531987 mirMAP -0.197868644128669 1.18634274549152e-09 NA NA NA hsa-miR-335-3p BMPR2 0.336785882180547 0.0542446207938138 -0.139496205223087 0.184586690531987 mirMAP -0.114360275773209 1.08386155358689e-05 NA NA NA hsa-miR-33a-5p BMPR2 1.12988965056352 3.35742517382153e-07 -0.139496205223087 0.184586690531987 mirMAP -0.13144127498652 5.68926289818898e-11 NA NA NA hsa-miR-342-3p BMPR2 0.99756868977753 9.28499866272332e-10 -0.139496205223087 0.184586690531987 PITA;miRanda;miRNATAP -0.191047581589733 1.74682992039476e-12 NA NA NA hsa-miR-3607-3p BMPR2 1.01377165357363 9.13355519701165e-05 -0.139496205223087 0.184586690531987 mirMAP;miRNATAP -0.121741691227365 1.3786099161398e-12 NA NA NA hsa-miR-362-3p BMPR2 -0.697212068252854 2.61718493418184e-06 -0.139496205223087 0.184586690531987 MirTarget;PITA;miRanda;miRNATAP -0.122445367990663 6.31669241103178e-05 NA NA NA hsa-miR-374a-3p BMPR2 -0.299190081500425 0.00682975596757891 -0.139496205223087 0.184586690531987 MirTarget;miRNATAP -0.199813505020102 1.25518447008432e-06 NA NA NA hsa-miR-374b-5p BMPR2 -0.288413933608091 0.0041474558664058 -0.139496205223087 0.184586690531987 mirMAP -0.237091125339359 1.68213481694949e-07 NA NA NA hsa-miR-429 BMPR2 0.559451508722375 0.00563641638673083 -0.139496205223087 0.184586690531987 mirMAP;miRNATAP -0.188334135030589 7.04029092745104e-18 NA NA NA hsa-miR-454-3p BMPR2 1.54137391927201 4.15861570449376e-20 -0.139496205223087 0.184586690531987 MirTarget;miRNATAP -0.251518687231701 1.34891920506374e-23 NA NA NA hsa-miR-532-5p BMPR2 -0.021857649390892 0.830992272120134 -0.139496205223087 0.184586690531987 PITA -0.165833264908345 0.000226557295205045 NA NA NA hsa-miR-582-3p BMPR2 -0.248056267546012 0.143798829508405 -0.139496205223087 0.184586690531987 PITA;miRNATAP -0.167776566720856 2.69759253127433e-10 NA NA NA hsa-miR-582-5p BMPR2 -0.0366995972742474 0.821827119138923 -0.139496205223087 0.184586690531987 mirMAP -0.205444812601611 7.87133394706222e-14 NA NA NA hsa-miR-590-3p BMPR2 0.221436901462551 0.0965904764063157 -0.139496205223087 0.184586690531987 MirTarget;miRanda;mirMAP;miRNATAP -0.195460511751591 9.20455649906434e-09 NA NA NA hsa-miR-590-5p BMPR2 0.763025362395968 3.65305892505623e-09 -0.139496205223087 0.184586690531987 MirTarget;PITA;miRNATAP -0.284570062508111 5.04912733257364e-17 NA NA NA hsa-miR-651-5p BMPR2 0.504713329111777 0.00155970216047171 -0.139496205223087 0.184586690531987 MirTarget -0.165290612569946 5.0212515338883e-09 NA NA NA hsa-miR-671-5p BMPR2 1.90920358947989 6.8158317757852e-31 -0.139496205223087 0.184586690531987 miRNATAP -0.183995055864294 5.62633202278756e-13 NA NA NA hsa-miR-7-1-3p BMPR2 1.13646121619622 1.49823237535933e-14 -0.139496205223087 0.184586690531987 mirMAP -0.211179242022324 9.20849384223251e-13 NA NA NA hsa-miR-92a-3p BMPR2 0.994679542307232 1.32587679156217e-16 -0.139496205223087 0.184586690531987 miRNAWalker2_validate;miRNATAP -0.304607041145454 2.3406161066217e-17 NA NA NA hsa-miR-93-3p BMPR2 1.69225547123293 1.50964095575087e-25 -0.139496205223087 0.184586690531987 miRNAWalker2_validate -0.195722631333366 9.59758334028653e-14 NA NA NA hsa-miR-93-5p BMPR2 1.61042951896619 5.1280369606967e-24 -0.139496205223087 0.184586690531987 miRNAWalker2_validate;MirTarget;miRNATAP -0.254658882643992 4.10011571861327e-22 NA NA NA hsa-miR-96-5p BMPR2 1.42326703011157 4.39736150032373e-14 -0.139496205223087 0.184586690531987 mirMAP -0.159564047878213 6.04351072034163e-12 NA NA NA hsa-miR-103a-3p BTRC 0.556219385347418 1.55815736455067e-09 -0.383838847043345 6.07764937720299e-07 MirTarget;miRNATAP -0.195127288018318 6.49428618338955e-08 NA NA NA hsa-miR-130b-3p BTRC 1.44628430084411 9.13980959861273e-24 -0.383838847043345 6.07764937720299e-07 mirMAP -0.135532527047066 9.23862520191604e-10 NA NA NA hsa-miR-130b-5p BTRC 1.77265255049999 1.43627774829684e-29 -0.383838847043345 6.07764937720299e-07 mirMAP -0.133699222917177 2.10371348524703e-11 NA NA NA hsa-miR-15a-5p BTRC 0.783550182002274 2.60699595655907e-11 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.174572467294465 3.90645232778685e-10 NA NA NA hsa-miR-15b-5p BTRC 0.85315666454713 3.79816274836297e-12 -0.383838847043345 6.07764937720299e-07 MirTarget;miRNATAP -0.165125615134741 5.59694781681588e-10 NA NA NA hsa-miR-16-1-3p BTRC 0.955017760172879 5.95379292601146e-11 -0.383838847043345 6.07764937720299e-07 mirMAP -0.120132845462012 1.02981409292927e-07 NA NA NA hsa-miR-16-5p BTRC 0.521122945828175 1.40561786410572e-06 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.140492227484468 5.77704176099401e-06 NA NA NA hsa-miR-28-5p BTRC -0.026996999089909 0.733047113251652 -0.383838847043345 6.07764937720299e-07 miRanda -0.225694488882788 1.57068578694702e-07 NA NA NA hsa-miR-320a BTRC 0.801356001806321 4.91397101474502e-09 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate;PITA -0.143436572641638 2.39851770787459e-09 NA NA NA hsa-miR-342-3p BTRC 0.99756868977753 9.28499866272332e-10 -0.383838847043345 6.07764937720299e-07 mirMAP -0.102049148946382 4.53666000542321e-07 NA NA NA hsa-miR-3913-5p BTRC 0.48532077857571 0.00112373589405304 -0.383838847043345 6.07764937720299e-07 mirMAP -0.136729656162249 1.03435499361847e-09 NA NA NA hsa-miR-505-3p BTRC 0.912823669571645 4.0549774967148e-13 -0.383838847043345 6.07764937720299e-07 MirTarget -0.135458976188229 2.04142565249063e-07 NA NA NA hsa-miR-92a-3p BTRC 0.994679542307232 1.32587679156217e-16 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate -0.128154090085504 2.37848689306587e-06 NA NA NA hsa-miR-93-3p BTRC 1.69225547123293 1.50964095575087e-25 -0.383838847043345 6.07764937720299e-07 mirMAP -0.121809769497493 4.71971183483907e-10 NA NA NA hsa-let-7g-5p CCND1 -0.250780249469264 0.00939610188330072 -0.0109881197784345 0.959465409721582 miRNATAP -0.424829740163156 1.3974509451707e-05 NA NA NA hsa-miR-106a-5p CCND1 0.67978010057847 0.00221925869726092 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.290355514799433 2.22440819238953e-12 NA NA NA hsa-miR-1266-5p CCND1 -0.595481713934774 0.0201336437562675 -0.0109881197784345 0.959465409721582 MirTarget -0.139245086566564 0.000186104290921039 NA NA NA hsa-miR-142-3p CCND1 1.12754191614028 1.68798138028946e-08 -0.0109881197784345 0.959465409721582 miRanda -0.212388247517233 4.15485864028608e-06 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 0.288897753038094 0.0900009317815725 -0.0109881197784345 0.959465409721582 PITA -0.191106128320911 0.000532572974747186 NA NA NA hsa-miR-150-5p CCND1 -0.243749814009231 0.331546276920338 -0.0109881197784345 0.959465409721582 mirMAP -0.180131286994855 1.27780213542857e-06 NA NA NA hsa-miR-155-5p CCND1 0.533437622040649 0.00248671179205372 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.205881873012998 0.000104382699617692 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15a-5p CCND1 0.783550182002274 2.60699595655907e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320464086146859 4.59241835770022e-05 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 0.85315666454713 3.79816274836297e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196519284459032 0.00913339894150689 NA NA NA hsa-miR-16-1-3p CCND1 0.955017760172879 5.95379292601146e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.299307340787817 2.12501301813106e-06 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.521122945828175 1.40561786410572e-06 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36160545188711 2.92815156758109e-05 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-19a-3p CCND1 1.35800152353624 2.80940447111944e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12556465980021 0.0080645437414565 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.757034032029085 2.99828133413343e-07 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.202417906859997 0.00132907107963613 NA NA NA hsa-miR-19b-3p CCND1 0.538732279378089 0.000622008277870679 -0.0109881197784345 0.959465409721582 miRNATAP -0.231848363677157 9.5371115518645e-05 NA NA NA hsa-miR-20a-5p CCND1 1.1531986665452 1.02385132917958e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150528956777027 0.00569825749150082 NA NA NA hsa-miR-20b-5p CCND1 0.345967670847176 0.232014828043601 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.250103392191291 2.8858693936891e-15 NA NA NA hsa-miR-29b-3p CCND1 -0.110721443686039 0.511264554091106 -0.0109881197784345 0.959465409721582 mirMAP -0.182509877041615 0.00109069300418897 NA NA NA hsa-miR-29c-3p CCND1 -2.08166260448948 8.3238369390898e-24 -0.0109881197784345 0.959465409721582 mirMAP -0.163903476961256 0.000152217345834049 NA NA NA hsa-miR-33a-3p CCND1 0.20371038027126 0.212335697664505 -0.0109881197784345 0.959465409721582 MirTarget -0.204409670414224 0.000471939794699908 NA NA NA hsa-miR-34a-5p CCND1 -0.117372471043915 0.364001947180738 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309736660444851 2.09961171943065e-05 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-425-5p CCND1 0.931027421598738 6.46235724408844e-08 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.149225802492201 0.00573052989307961 NA NA NA hsa-miR-497-5p CCND1 -0.966244470847844 5.26505649147857e-12 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.266892367444044 4.86480308910068e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p CCND1 0.221436901462551 0.0965904764063157 -0.0109881197784345 0.959465409721582 mirMAP -0.238086291527056 0.000767975801470639 NA NA NA hsa-miR-7-1-3p CCND1 1.13646121619622 1.49823237535933e-14 -0.0109881197784345 0.959465409721582 mirMAP -0.221180507811752 0.000359772635429063 NA NA NA hsa-miR-9-5p CCND1 1.65694862043766 2.08325802567323e-05 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.135043708232949 1.13694784335034e-08 NA NA NA hsa-miR-92a-3p CCND1 0.994679542307232 1.32587679156217e-16 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.235491439560111 0.00199944237198536 NA NA NA hsa-miR-942-5p CCND1 0.678652135586536 2.58063518495056e-07 -0.0109881197784345 0.959465409721582 MirTarget -0.230928848103094 0.0011113987419772 NA NA NA hsa-miR-224-3p CCND2 0.502645536188015 0.0081142387260641 0.148711904010299 0.532420631377314 mirMAP -0.312870902501466 8.12446049333883e-09 NA NA NA hsa-miR-27b-3p CCND3 -0.732682718863563 2.26896143573324e-09 -0.048043868607146 0.631560985924681 miRNAWalker2_validate -0.132150579088403 0.000160876577060277 NA NA NA hsa-miR-146b-5p CDH1 0.917975986853978 3.33749259316025e-09 -0.12671230350084 0.468601955580465 miRanda -0.207454583541764 1.62811345500202e-05 NA NA NA hsa-miR-186-5p CDH1 0.353452958261612 0.000145058448579496 -0.12671230350084 0.468601955580465 mirMAP -0.384293481534067 2.57482947024608e-06 NA NA NA hsa-miR-199a-5p CDH1 -0.364835768178638 0.0435119211101981 -0.12671230350084 0.468601955580465 MirTarget;miRanda -0.178738126529922 1.98814329773256e-05 25080937 In contrast inhibition of miR-199a-5p impaired the metastatic potential of GC cells in vitro and in vivo and E-cadherin was identified as a direct and functional target of miR-199a-5p in GC cells gastric cancer hsa-miR-25-3p CDH1 0.76549796417801 3.32282098247097e-11 -0.12671230350084 0.468601955580465 miRNAWalker2_validate;miRTarBase -0.20771412089593 0.00138783998011518 22450326 We further identified that miR-25 directly targeted CDH1 3'-untranslated region 3'UTR and repressed the expression of CDH1; These results for the first time demonstrate that miR-25 promotes ESCC cell migration and invasion by suppressing CDH1 expression cell migration esophageal cancer hsa-miR-30c-5p CDH1 0.021222006155897 0.886366656528128 -0.12671230350084 0.468601955580465 miRNAWalker2_validate -0.203652584768453 7.0529872361206e-05 24112779 Repression of miR-30c through its inhibitor resulted in reduction of E-cadherin production and promotion of epithelial-mesenchymal transition EMT while overexpression of miR-30c inhibited EMT in RCC cells; Our findings propose a model that hypoxia induces EMT in RCC cells through downregulation of miR-30c which leads to subsequent increase of Slug expression and repression of E-cadherin production and suggest a potential application of miR-30c in RCC treatment kidney renal cell cancer hsa-miR-338-3p CDH1 -0.948755228846395 8.99167125682392e-08 -0.12671230350084 0.468601955580465 MirTarget;miRanda -0.130945790047589 0.00198841813931765 NA NA NA hsa-miR-342-3p CDH1 0.99756868977753 9.28499866272332e-10 -0.12671230350084 0.468601955580465 miRanda -0.164921490888613 0.00032541986361263 NA NA NA hsa-miR-193a-3p CRB2 0.22120710726779 0.111827069464729 -0.820074296857395 0.0289800764378884 miRanda -0.448572857513079 0.000140872327308934 NA NA NA hsa-miR-452-3p CRB2 1.09618110917892 2.21867884261816e-07 -0.820074296857395 0.0289800764378884 MirTarget -0.299481329054191 8.59426707871e-05 NA NA NA hsa-miR-148a-5p CSNK1E -1.00478606532747 1.38045244999229e-07 0.548936364081841 1.10720819240592e-10 miRNATAP -0.116497957841565 1.41533291460369e-09 NA NA NA hsa-miR-149-5p CTGF 0.443278770827687 0.0642022866136881 -0.699854006306855 0.00293574224012784 miRNATAP -0.206067639335264 1.29166217789756e-06 NA NA NA hsa-miR-16-2-3p CTGF 1.1567130855258 1.01867256952189e-14 -0.699854006306855 0.00293574224012784 MirTarget -0.582055075675304 2.84038268255854e-19 NA NA NA hsa-miR-18a-5p CTGF 1.65455873230328 3.76457892277775e-20 -0.699854006306855 0.00293574224012784 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.362421184621041 2.05011746973646e-11 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 1.35800152353624 2.80940447111944e-12 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.335760671812675 4.25852281864162e-11 NA NA NA hsa-miR-19b-3p CTGF 0.538732279378089 0.000622008277870679 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.381940203186411 2.89765714201214e-09 NA NA NA hsa-miR-205-5p CTGF 1.50759485376634 2.0003886738248e-16 -0.699854006306855 0.00293574224012784 miRNAWalker2_validate;miRTarBase -0.525166028191004 6.48498496273652e-24 NA NA NA hsa-miR-26b-3p CTGF 0.421575313079363 0.00223298166810883 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.369243091033105 6.07071431559366e-07 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-26b-5p CTGF -0.254478038884324 0.0285227763044636 -0.699854006306855 0.00293574224012784 miRNATAP -0.237207034513592 0.00770467360550299 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-361-3p CTGF 0.272298288982435 0.0147874880476998 -0.699854006306855 0.00293574224012784 MirTarget;miRNATAP -0.296605329970702 0.0013393001654514 NA NA NA hsa-miR-590-3p CTGF 0.221436901462551 0.0965904764063157 -0.699854006306855 0.00293574224012784 PITA;miRanda -0.337560595220434 1.18646746550991e-05 NA NA NA hsa-miR-7-1-3p CTGF 1.13646121619622 1.49823237535933e-14 -0.699854006306855 0.00293574224012784 MirTarget -0.527490782721506 1.52723259205055e-15 NA NA NA hsa-miR-181b-5p CTNNA1 0.974255518824355 2.64876280203475e-16 -0.529571982664635 7.46262979775313e-12 MirTarget -0.117998819758674 2.44803276838063e-05 NA NA NA hsa-miR-181d-5p CTNNA1 0.367649966373544 0.00537300571455306 -0.529571982664635 7.46262979775313e-12 MirTarget -0.108213088660294 2.88794444179695e-05 NA NA NA hsa-miR-197-3p CTNNA1 0.878693269130833 3.84847526014135e-15 -0.529571982664635 7.46262979775313e-12 MirTarget -0.141155467679356 2.18013534893797e-06 NA NA NA hsa-miR-542-3p CTNNA1 0.643308814904977 8.81635403230104e-07 -0.529571982664635 7.46262979775313e-12 miRanda -0.121388906155482 2.6760958944602e-06 NA NA NA hsa-let-7a-3p CTNNB1 0.0966652362351867 0.423761916840503 -0.300300567639502 0.00163620046474668 MirTarget;miRNATAP -0.133594372296952 0.000109116957423689 NA NA NA hsa-miR-320a CTNNB1 0.801356001806321 4.91397101474502e-09 -0.300300567639502 0.00163620046474668 PITA;miRanda;miRNATAP -0.127056972080136 2.1032822504976e-05 NA NA NA hsa-miR-532-3p CTNNB1 0.80240056676907 1.08989551712617e-09 -0.300300567639502 0.00163620046474668 miRNAWalker2_validate -0.14291782747995 4.05395930207998e-06 NA NA NA hsa-miR-7-1-3p CTNNB1 1.13646121619622 1.49823237535933e-14 -0.300300567639502 0.00163620046474668 mirMAP -0.127239564192006 3.10292737404531e-06 NA NA NA hsa-miR-146b-5p DLG1 0.917975986853978 3.33749259316025e-09 -0.291621335138092 0.00481463476096704 MirTarget;miRanda -0.238896846024328 8.19864630261325e-18 NA NA NA hsa-miR-148b-5p DLG1 1.1533193737265 7.26420964688337e-13 -0.291621335138092 0.00481463476096704 MirTarget -0.105551479481949 0.000140089180983425 NA NA NA hsa-miR-186-5p DLG1 0.353452958261612 0.000145058448579496 -0.291621335138092 0.00481463476096704 MirTarget;mirMAP;miRNATAP -0.211928407505243 1.24974832883608e-05 NA NA NA hsa-miR-21-5p DLG1 1.62465922021121 3.44191300985109e-58 -0.291621335138092 0.00481463476096704 miRNAWalker2_validate -0.166305962111126 2.97103115608929e-05 NA NA NA hsa-miR-320a DLG1 0.801356001806321 4.91397101474502e-09 -0.291621335138092 0.00481463476096704 miRanda -0.120040692169725 0.000216983870644613 NA NA NA hsa-miR-671-5p DLG1 1.90920358947989 6.8158317757852e-31 -0.291621335138092 0.00481463476096704 MirTarget;PITA -0.119362061941225 2.97219321579132e-06 NA NA NA hsa-miR-1301-3p DLG2 2.13677668481885 6.11093268540831e-44 -4.45681242642708 3.79887988466741e-38 MirTarget -0.731981458147589 9.9055202362383e-15 NA NA NA hsa-miR-130a-3p DLG2 0.67051191119964 4.89747518735144e-06 -4.45681242642708 3.79887988466741e-38 miRNATAP -0.686906646579124 2.27687154046859e-10 NA NA NA hsa-miR-130b-5p DLG2 1.77265255049999 1.43627774829684e-29 -4.45681242642708 3.79887988466741e-38 miRNATAP -0.525366858968005 5.64154747600715e-08 NA NA NA hsa-miR-135b-5p DLG2 1.5570143078477 4.60753610971455e-13 -4.45681242642708 3.79887988466741e-38 MirTarget -0.457801504415801 2.8289722521578e-10 NA NA NA hsa-miR-146b-5p DLG2 0.917975986853978 3.33749259316025e-09 -4.45681242642708 3.79887988466741e-38 miRanda -0.517176134058095 4.37586433018637e-07 NA NA NA hsa-miR-148b-5p DLG2 1.1533193737265 7.26420964688337e-13 -4.45681242642708 3.79887988466741e-38 mirMAP -0.518054481760222 1.76842220889191e-07 NA NA NA hsa-miR-15b-3p DLG2 1.05020782493504 6.38723677324836e-14 -4.45681242642708 3.79887988466741e-38 mirMAP -0.70571459415258 2.66149651654049e-10 NA NA NA hsa-miR-16-2-3p DLG2 1.1567130855258 1.01867256952189e-14 -4.45681242642708 3.79887988466741e-38 mirMAP -0.773624347773113 8.15141154594614e-14 NA NA NA hsa-miR-17-5p DLG2 1.41924888736771 2.75805544953758e-18 -4.45681242642708 3.79887988466741e-38 mirMAP -0.7930810085393 2.5183841689465e-17 NA NA NA hsa-miR-182-5p DLG2 1.15060905311096 6.25565852529946e-10 -4.45681242642708 3.79887988466741e-38 miRNATAP -0.345565072979625 5.31602669433656e-05 NA NA NA hsa-miR-185-5p DLG2 0.675225177054909 1.84953949190805e-13 -4.45681242642708 3.79887988466741e-38 MirTarget;miRNATAP -1.04254085126055 1.46618482075797e-09 NA NA NA hsa-miR-186-5p DLG2 0.353452958261612 0.000145058448579496 -4.45681242642708 3.79887988466741e-38 mirMAP -0.514277217712597 0.00339569090361808 NA NA NA hsa-miR-19a-3p DLG2 1.35800152353624 2.80940447111944e-12 -4.45681242642708 3.79887988466741e-38 mirMAP -0.600239548787944 5.7854420153695e-14 NA NA NA hsa-miR-19b-3p DLG2 0.538732279378089 0.000622008277870679 -4.45681242642708 3.79887988466741e-38 mirMAP -0.432667212072796 2.39121508771013e-05 NA NA NA hsa-miR-205-5p DLG2 1.50759485376634 2.0003886738248e-16 -4.45681242642708 3.79887988466741e-38 MirTarget;miRNATAP -0.584087003851115 4.28909698461449e-12 NA NA NA hsa-miR-20a-5p DLG2 1.1531986665452 1.02385132917958e-11 -4.45681242642708 3.79887988466741e-38 mirMAP -0.635096102251832 5.65653746395955e-12 NA NA NA hsa-miR-22-5p DLG2 0.706731861922839 3.44318705980007e-07 -4.45681242642708 3.79887988466741e-38 MirTarget;miRNATAP -0.677102218431137 3.61713990297775e-09 NA NA NA hsa-miR-23a-3p DLG2 0.348231698801568 6.4911858506572e-05 -4.45681242642708 3.79887988466741e-38 MirTarget;miRNATAP -0.693699666253612 0.000209440798789965 NA NA NA hsa-miR-25-3p DLG2 0.76549796417801 3.32282098247097e-11 -4.45681242642708 3.79887988466741e-38 mirMAP -0.477060032310825 0.000574699838157217 NA NA NA hsa-miR-27a-5p DLG2 0.480723189397622 0.00422876220095238 -4.45681242642708 3.79887988466741e-38 miRNATAP -0.391347623571175 4.65737233814576e-05 NA NA NA hsa-miR-29b-1-5p DLG2 1.39669186711325 4.36960953138935e-11 -4.45681242642708 3.79887988466741e-38 mirMAP -0.631045573453735 5.0866270292033e-18 NA NA NA hsa-miR-3127-5p DLG2 0.706677736144125 1.91821443636366e-05 -4.45681242642708 3.79887988466741e-38 mirMAP -0.327289692406461 0.000785933617085693 NA NA NA hsa-miR-320a DLG2 0.801356001806321 4.91397101474502e-09 -4.45681242642708 3.79887988466741e-38 PITA;miRanda;mirMAP;miRNATAP -0.409825438239369 0.000457944883872853 NA NA NA hsa-miR-320b DLG2 1.23473838180754 3.04337566045537e-14 -4.45681242642708 3.79887988466741e-38 PITA;miRanda;mirMAP;miRNATAP -0.445824145989665 4.18432625211224e-06 NA NA NA hsa-miR-33a-5p DLG2 1.12988965056352 3.35742517382153e-07 -4.45681242642708 3.79887988466741e-38 mirMAP -0.269974338575987 0.000187083686972456 NA NA NA hsa-miR-33b-5p DLG2 0.681845193600723 0.00407790722487864 -4.45681242642708 3.79887988466741e-38 mirMAP -0.254892185583427 0.000276470444296905 NA NA NA hsa-miR-3613-5p DLG2 0.410363235348614 0.00534956684590092 -4.45681242642708 3.79887988466741e-38 MirTarget;miRNATAP -0.487563483621917 8.6750421680194e-06 NA NA NA hsa-miR-374b-3p DLG2 0.425603499218802 0.00146686864653282 -4.45681242642708 3.79887988466741e-38 mirMAP -0.479390801682854 7.94389471199906e-05 NA NA NA hsa-miR-421 DLG2 0.945488088619653 2.35762398527362e-09 -4.45681242642708 3.79887988466741e-38 miRanda -0.350310818273928 0.000541001706722213 NA NA NA hsa-miR-484 DLG2 0.918280909791707 1.39168306854263e-14 -4.45681242642708 3.79887988466741e-38 MirTarget;PITA -0.624978413527716 2.33255876401819e-06 NA NA NA hsa-miR-505-5p DLG2 1.25888458076414 7.80089782306577e-13 -4.45681242642708 3.79887988466741e-38 MirTarget;miRNATAP -0.451872939647877 4.63702996165128e-07 NA NA NA hsa-miR-511-5p DLG2 0.214339847118675 0.232372953100021 -4.45681242642708 3.79887988466741e-38 MirTarget -0.284538307579798 0.00166918058993373 NA NA NA hsa-miR-576-5p DLG2 0.940432050128373 6.90227595663302e-12 -4.45681242642708 3.79887988466741e-38 PITA;mirMAP -0.803065013291914 1.95480342112721e-12 NA NA NA hsa-miR-590-3p DLG2 0.221436901462551 0.0965904764063157 -4.45681242642708 3.79887988466741e-38 PITA;miRanda;mirMAP -0.321753137010592 0.00856816751558223 NA NA NA hsa-miR-590-5p DLG2 0.763025362395968 3.65305892505623e-09 -4.45681242642708 3.79887988466741e-38 PITA;miRanda -0.729929423432169 2.59422145651238e-09 NA NA NA hsa-miR-7-1-3p DLG2 1.13646121619622 1.49823237535933e-14 -4.45681242642708 3.79887988466741e-38 MirTarget -0.696693062911912 3.87539214817548e-11 NA NA NA hsa-miR-708-3p DLG2 1.32647174389322 4.87465491977979e-16 -4.45681242642708 3.79887988466741e-38 mirMAP -0.535008562079685 2.10963160295997e-08 NA NA NA hsa-miR-769-3p DLG2 0.89886491506181 2.21711828717073e-08 -4.45681242642708 3.79887988466741e-38 PITA;miRNATAP -0.316658488401442 0.00164467050156537 NA NA NA hsa-miR-877-5p DLG2 1.97571572671705 2.0032239372269e-19 -4.45681242642708 3.79887988466741e-38 MirTarget -0.586987260227101 5.71078953507138e-15 NA NA NA hsa-miR-92a-3p DLG2 0.994679542307232 1.32587679156217e-16 -4.45681242642708 3.79887988466741e-38 mirMAP -0.848655021531928 5.50206132237362e-11 NA NA NA hsa-miR-92b-3p DLG2 0.869628761112414 4.71129204795212e-09 -4.45681242642708 3.79887988466741e-38 mirMAP -0.413189085517355 0.000124115949388461 NA NA NA hsa-miR-93-3p DLG2 1.69225547123293 1.50964095575087e-25 -4.45681242642708 3.79887988466741e-38 MirTarget;miRNATAP -0.64121261947609 8.01510018124087e-12 NA NA NA hsa-miR-940 DLG2 1.25303020594374 1.3005368359451e-10 -4.45681242642708 3.79887988466741e-38 MirTarget;PITA;miRNATAP -0.330668757058063 6.123553207984e-05 NA NA NA hsa-miR-944 DLG2 1.47323925060177 2.61626403984929e-13 -4.45681242642708 3.79887988466741e-38 PITA;mirMAP;miRNATAP -0.591533148530629 1.3263072023856e-14 NA NA NA hsa-miR-299-5p DLG3 -1.92445654064493 1.52402531359074e-16 -0.713019134141013 1.84020990167787e-08 miRNATAP -0.136056900508893 3.4894523657015e-09 NA NA NA hsa-miR-369-3p DLG3 -1.2344419076994 2.66882944171146e-10 -0.713019134141013 1.84020990167787e-08 miRNATAP -0.137191046320193 9.5251322803895e-07 NA NA NA hsa-miR-450b-5p DLG3 1.25529820885833 1.18847120528666e-15 -0.713019134141013 1.84020990167787e-08 PITA -0.185192781792956 7.09036267011878e-08 NA NA NA hsa-miR-539-5p DLG3 -0.15206998860136 0.492550733728996 -0.713019134141013 1.84020990167787e-08 mirMAP -0.102916344794589 5.1264397738469e-05 NA NA NA hsa-miR-7-5p DLG3 1.55674721532755 2.41989824363914e-11 -0.713019134141013 1.84020990167787e-08 mirMAP -0.111916307670127 5.13074130847688e-06 NA NA NA hsa-miR-107 DVL1 -0.0447040564279497 0.671618791096755 -0.315083254913112 0.00336463703005417 PITA;miRanda -0.353957434868849 5.20660445094226e-16 NA NA NA hsa-miR-378a-3p DVL1 -1.50453783521372 9.41694954361173e-17 -0.315083254913112 0.00336463703005417 miRNAWalker2_validate -0.10296338019986 3.82097488279943e-05 NA NA NA hsa-miR-744-5p DVL1 0.436098372735845 0.000850400989351181 -0.315083254913112 0.00336463703005417 miRNAWalker2_validate -0.109422905940439 0.00226270986598123 NA NA NA hsa-miR-125a-5p DVL3 0.215366061934933 0.119550904549401 0.761578628594005 2.30416706929068e-12 PITA -0.122644441122875 0.000449656811680475 NA NA NA hsa-miR-146b-3p DVL3 0.186534815310862 0.169137114997759 0.761578628594005 2.30416706929068e-12 MirTarget -0.109853957067874 0.00209625870175301 NA NA NA hsa-miR-26b-5p DVL3 -0.254478038884324 0.0285227763044636 0.761578628594005 2.30416706929068e-12 miRNAWalker2_validate -0.206441831856518 6.28828682878475e-07 NA NA NA hsa-miR-29b-2-5p DVL3 -0.502720326849742 0.000730448246894952 0.761578628594005 2.30416706929068e-12 MirTarget -0.108629722692568 0.000781479246536973 NA NA NA hsa-miR-30d-3p DVL3 -0.577371911152798 2.02950840095287e-06 0.761578628594005 2.30416706929068e-12 MirTarget -0.143044131405002 0.000298094745922076 NA NA NA hsa-miR-338-3p DVL3 -0.948755228846395 8.99167125682392e-08 0.761578628594005 2.30416706929068e-12 miRanda -0.20337710422478 9.09837146114886e-15 NA NA NA hsa-miR-130a-3p FBXW11 0.67051191119964 4.89747518735144e-06 -0.522572976947842 4.41162314947416e-11 MirTarget -0.149633140410536 1.6229332714645e-10 NA NA NA hsa-miR-130b-3p FBXW11 1.44628430084411 9.13980959861273e-24 -0.522572976947842 4.41162314947416e-11 MirTarget -0.129277578106721 2.17081583533824e-08 NA NA NA hsa-miR-17-5p FBXW11 1.41924888736771 2.75805544953758e-18 -0.522572976947842 4.41162314947416e-11 TargetScan;miRNATAP -0.149464465054655 2.47315320459538e-13 NA NA NA hsa-miR-182-5p FBXW11 1.15060905311096 6.25565852529946e-10 -0.522572976947842 4.41162314947416e-11 MirTarget;miRNATAP -0.120747941011624 3.60841314193127e-11 NA NA NA hsa-miR-186-5p FBXW11 0.353452958261612 0.000145058448579496 -0.522572976947842 4.41162314947416e-11 mirMAP -0.13312953977449 0.000439791124138411 NA NA NA hsa-miR-19a-3p FBXW11 1.35800152353624 2.80940447111944e-12 -0.522572976947842 4.41162314947416e-11 MirTarget -0.130912274169801 3.32267780243271e-14 NA NA NA hsa-miR-19b-3p FBXW11 0.538732279378089 0.000622008277870679 -0.522572976947842 4.41162314947416e-11 MirTarget -0.136461162780345 4.76330312426609e-10 NA NA NA hsa-miR-20a-5p FBXW11 1.1531986665452 1.02385132917958e-11 -0.522572976947842 4.41162314947416e-11 miRNATAP -0.142819638281362 6.93694872629742e-13 NA NA NA hsa-miR-301a-3p FBXW11 2.14132004241926 4.46255413526808e-25 -0.522572976947842 4.41162314947416e-11 MirTarget -0.117240857080766 1.10194975126046e-13 NA NA NA hsa-miR-374b-5p FBXW11 -0.288413933608091 0.0041474558664058 -0.522572976947842 4.41162314947416e-11 mirMAP -0.118834281338581 0.000701729269418148 NA NA NA hsa-miR-450a-5p FBXW11 1.74695686398479 4.62583996044297e-22 -0.522572976947842 4.41162314947416e-11 miRNAWalker2_validate -0.140707191685803 8.97461750691927e-15 NA NA NA hsa-miR-450b-5p FBXW11 1.25529820885833 1.18847120528666e-15 -0.522572976947842 4.41162314947416e-11 mirMAP -0.121821112095609 1.54398186365388e-08 NA NA NA hsa-miR-454-3p FBXW11 1.54137391927201 4.15861570449376e-20 -0.522572976947842 4.41162314947416e-11 MirTarget -0.138730446024612 2.18382017884097e-12 NA NA NA hsa-miR-505-3p FBXW11 0.912823669571645 4.0549774967148e-13 -0.522572976947842 4.41162314947416e-11 mirMAP -0.148076424279681 4.55606746874584e-08 NA NA NA hsa-miR-664a-3p FBXW11 -0.256108763664991 0.0513188660751664 -0.522572976947842 4.41162314947416e-11 mirMAP -0.101393949326574 0.000147998855741962 NA NA NA hsa-miR-93-5p FBXW11 1.61042951896619 5.1280369606967e-24 -0.522572976947842 4.41162314947416e-11 miRNATAP -0.148862160221229 5.23860983466119e-13 NA NA NA hsa-miR-96-5p FBXW11 1.42326703011157 4.39736150032373e-14 -0.522572976947842 4.41162314947416e-11 MirTarget;TargetScan;miRNATAP -0.128997421861498 3.86315690804369e-13 NA NA NA hsa-miR-18a-5p FGF1 1.65455873230328 3.76457892277775e-20 -0.258011343667108 0.26760431731263 MirTarget -0.277496437672487 2.43959718026235e-07 NA NA NA hsa-miR-193a-3p FGF1 0.22120710726779 0.111827069464729 -0.258011343667108 0.26760431731263 PITA -0.202240172681954 0.00567870004542482 NA NA NA hsa-miR-205-5p FGF1 1.50759485376634 2.0003886738248e-16 -0.258011343667108 0.26760431731263 mirMAP -0.198163178508369 0.000211883664826537 NA NA NA hsa-miR-2355-5p FGF1 1.47205546931107 8.65192179636668e-19 -0.258011343667108 0.26760431731263 MirTarget -0.185602955162296 0.00160680328845676 NA NA NA hsa-miR-484 FGF1 0.918280909791707 1.39168306854263e-14 -0.258011343667108 0.26760431731263 MirTarget;PITA;miRNATAP -0.389291918702885 2.4520525029842e-06 NA NA NA hsa-miR-532-3p FGF1 0.80240056676907 1.08989551712617e-09 -0.258011343667108 0.26760431731263 miRNATAP -0.216024621372653 0.004507077796501 NA NA NA hsa-miR-576-5p FGF1 0.940432050128373 6.90227595663302e-12 -0.258011343667108 0.26760431731263 PITA;mirMAP -0.292914912309583 5.16069042343911e-05 NA NA NA hsa-miR-590-5p FGF1 0.763025362395968 3.65305892505623e-09 -0.258011343667108 0.26760431731263 MirTarget;miRanda;miRNATAP -0.317241137495249 3.95390401682399e-05 NA NA NA hsa-miR-629-5p FGF1 0.461215538037447 8.95262667860215e-06 -0.258011343667108 0.26760431731263 MirTarget -0.658892526979509 6.2109593316048e-12 NA NA NA hsa-miR-944 FGF1 1.47323925060177 2.61626403984929e-13 -0.258011343667108 0.26760431731263 mirMAP -0.319683604411362 3.57117911228316e-11 NA NA NA hsa-miR-542-3p FRMD1 0.643308814904977 8.81635403230104e-07 -1.0741657793709 0.00203834932373137 miRanda -0.374639888011354 0.00118709052695447 NA NA NA hsa-miR-101-3p FRMD6 -1.91263766544878 1.50270129259053e-39 0.249399576531852 0.0502386171273504 miRNAWalker2_validate -0.122167307932927 0.000535640564542282 NA NA NA hsa-miR-106a-5p FRMD6 0.67978010057847 0.00221925869726092 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.156025777966108 1.86702844729481e-10 NA NA NA hsa-miR-106b-5p FRMD6 0.50378717276868 1.45412404526866e-05 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.186963463671676 8.28432928039642e-05 NA NA NA hsa-miR-130a-3p FRMD6 0.67051191119964 4.89747518735144e-06 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.113738132510135 0.00245765330141413 NA NA NA hsa-miR-140-3p FRMD6 -0.967453553824782 7.6999446305445e-23 0.249399576531852 0.0502386171273504 PITA -0.206848148924162 0.000139704247679512 NA NA NA hsa-miR-140-5p FRMD6 -0.412389003031485 0.000136051708543369 0.249399576531852 0.0502386171273504 miRanda -0.295073969381205 6.31074297501775e-09 NA NA NA hsa-miR-146a-5p FRMD6 -0.0201236699646614 0.905882759106561 0.249399576531852 0.0502386171273504 MirTarget -0.20160726670391 3.78005381357243e-10 NA NA NA hsa-miR-146b-5p FRMD6 0.917975986853978 3.33749259316025e-09 0.249399576531852 0.0502386171273504 MirTarget;miRanda -0.17326290952819 7.35556961507798e-07 NA NA NA hsa-miR-15b-3p FRMD6 1.05020782493504 6.38723677324836e-14 0.249399576531852 0.0502386171273504 mirMAP -0.118501096314006 0.00221117241691608 NA NA NA hsa-miR-16-2-3p FRMD6 1.1567130855258 1.01867256952189e-14 0.249399576531852 0.0502386171273504 mirMAP -0.209733494722364 4.44344986289078e-09 NA NA NA hsa-miR-17-5p FRMD6 1.41924888736771 2.75805544953758e-18 0.249399576531852 0.0502386171273504 MirTarget;TargetScan;miRNATAP -0.124102383528019 0.000160427831416839 NA NA NA hsa-miR-195-3p FRMD6 -0.624259620429699 0.000164279659144497 0.249399576531852 0.0502386171273504 mirMAP -0.141551261650507 2.21075424868298e-05 NA NA NA hsa-miR-200a-3p FRMD6 0.607140814457753 0.00289840524858752 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.111870689011861 3.4445514635138e-05 NA NA NA hsa-miR-20a-5p FRMD6 1.1531986665452 1.02385132917958e-11 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.156672025621092 8.68165292908032e-07 NA NA NA hsa-miR-20b-5p FRMD6 0.345967670847176 0.232014828043601 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.162257582988814 2.20285983968393e-18 NA NA NA hsa-miR-217 FRMD6 -1.35391381055929 2.42394951427902e-09 0.249399576531852 0.0502386171273504 miRanda -0.106096727445002 9.15828514258393e-06 NA NA NA hsa-miR-29b-2-5p FRMD6 -0.502720326849742 0.000730448246894952 0.249399576531852 0.0502386171273504 MirTarget -0.313694090741784 3.20030887668039e-18 NA NA NA hsa-miR-30a-5p FRMD6 -1.79779915425811 1.93360169837799e-26 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.196498693311235 1.60604531490294e-10 NA NA NA hsa-miR-30b-5p FRMD6 -0.400238605368173 0.00346540992719245 0.249399576531852 0.0502386171273504 MirTarget -0.358438781847163 5.0500022593346e-20 NA NA NA hsa-miR-30c-5p FRMD6 0.021222006155897 0.886366656528128 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.302286555189911 1.06887220359093e-16 NA NA NA hsa-miR-30d-5p FRMD6 -0.38399848121878 0.000171129616944749 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.261696315040375 1.31019656418188e-06 NA NA NA hsa-miR-30e-5p FRMD6 -1.02114836019762 6.81961221797866e-17 0.249399576531852 0.0502386171273504 MirTarget -0.257954939984407 3.31414956463243e-09 NA NA NA hsa-miR-320a FRMD6 0.801356001806321 4.91397101474502e-09 0.249399576531852 0.0502386171273504 miRanda -0.232850663241424 3.85069728407895e-09 NA NA NA hsa-miR-340-5p FRMD6 -0.608415693437977 4.44345153563513e-05 0.249399576531852 0.0502386171273504 MirTarget -0.150854725874099 4.39138287069079e-05 NA NA NA hsa-miR-3613-5p FRMD6 0.410363235348614 0.00534956684590092 0.249399576531852 0.0502386171273504 miRNATAP -0.165156063654087 1.0362079919548e-05 NA NA NA hsa-miR-362-3p FRMD6 -0.697212068252854 2.61718493418184e-06 0.249399576531852 0.0502386171273504 miRanda;miRNATAP -0.167934545941062 5.88766379956604e-06 NA NA NA hsa-miR-374a-5p FRMD6 -0.621903385111545 6.61791773205282e-12 0.249399576531852 0.0502386171273504 mirMAP -0.227282408045049 0.00017289982248667 NA NA NA hsa-miR-374b-5p FRMD6 -0.288413933608091 0.0041474558664058 0.249399576531852 0.0502386171273504 mirMAP -0.408587121366218 5.01014325773592e-14 NA NA NA hsa-miR-454-3p FRMD6 1.54137391927201 4.15861570449376e-20 0.249399576531852 0.0502386171273504 MirTarget -0.202980541182922 9.31496934834375e-11 NA NA NA hsa-miR-501-5p FRMD6 1.02806906860218 1.63456814370548e-09 0.249399576531852 0.0502386171273504 MirTarget;PITA;miRNATAP -0.113721899567387 0.00045419946908918 NA NA NA hsa-miR-582-5p FRMD6 -0.0366995972742474 0.821827119138923 0.249399576531852 0.0502386171273504 MirTarget;PITA;miRNATAP -0.242382573675648 4.09707656586511e-13 NA NA NA hsa-miR-590-3p FRMD6 0.221436901462551 0.0965904764063157 0.249399576531852 0.0502386171273504 miRanda -0.19928078599039 1.56419663897085e-06 NA NA NA hsa-miR-671-5p FRMD6 1.90920358947989 6.8158317757852e-31 0.249399576531852 0.0502386171273504 MirTarget -0.106671156831292 0.000730550985153595 NA NA NA hsa-miR-7-1-3p FRMD6 1.13646121619622 1.49823237535933e-14 0.249399576531852 0.0502386171273504 MirTarget -0.211345746979718 5.15977646276882e-09 NA NA NA hsa-miR-93-5p FRMD6 1.61042951896619 5.1280369606967e-24 0.249399576531852 0.0502386171273504 MirTarget;miRNATAP -0.171936887804237 1.85620623129308e-07 NA NA NA hsa-miR-148b-5p FZD1 1.1533193737265 7.26420964688337e-13 0.202370822663888 0.202574353586073 MirTarget -0.22229623865695 1.40805789378432e-07 NA NA NA hsa-miR-186-5p FZD1 0.353452958261612 0.000145058448579496 0.202370822663888 0.202574353586073 mirMAP -0.443819315869232 1.78337309659339e-09 NA NA NA hsa-miR-192-5p FZD1 0.380924502586635 0.00986961967409205 0.202370822663888 0.202574353586073 miRNAWalker2_validate -0.17849780873765 0.000133115118940476 NA NA NA hsa-miR-200a-5p FZD1 0.701063526850019 0.000188402923774663 0.202370822663888 0.202574353586073 MirTarget -0.154567543120868 2.24969270904799e-05 NA NA NA hsa-miR-200b-5p FZD1 0.02621402664548 0.883725338810228 0.202370822663888 0.202574353586073 MirTarget -0.117979067492686 0.002253938989083 NA NA NA hsa-miR-205-3p FZD1 1.2960640797621 5.80786479909147e-11 0.202370822663888 0.202574353586073 mirMAP -0.221578243093832 4.89540221644546e-11 NA NA NA hsa-miR-29b-3p FZD1 -0.110721443686039 0.511264554091106 0.202370822663888 0.202574353586073 mirMAP -0.34391864667725 5.97933489498062e-18 NA NA NA hsa-miR-590-3p FZD1 0.221436901462551 0.0965904764063157 0.202370822663888 0.202574353586073 miRanda -0.24179842471756 2.96465190140345e-06 NA NA NA hsa-miR-944 FZD1 1.47323925060177 2.61626403984929e-13 0.202370822663888 0.202574353586073 mirMAP -0.102262312196088 0.00225405667409644 NA NA NA hsa-miR-15a-5p FZD10 0.783550182002274 2.60699595655907e-11 -0.311388129314746 0.219758577435407 miRNATAP -0.399132547382322 1.52329328716641e-05 NA NA NA hsa-miR-16-5p FZD10 0.521122945828175 1.40561786410572e-06 -0.311388129314746 0.219758577435407 miRNATAP -0.504383659194181 6.37712767675761e-07 NA NA NA hsa-miR-25-3p FZD10 0.76549796417801 3.32282098247097e-11 -0.311388129314746 0.219758577435407 miRNATAP -0.285129466248301 0.00253280592864319 NA NA NA hsa-miR-424-5p FZD10 1.48125289532143 9.10372985713165e-19 -0.311388129314746 0.219758577435407 miRNATAP -0.186474334748627 0.0034494575160454 NA NA NA hsa-miR-92a-3p FZD10 0.994679542307232 1.32587679156217e-16 -0.311388129314746 0.219758577435407 miRNATAP -0.262412611999907 0.00338878419687546 NA NA NA hsa-let-7f-1-3p FZD3 0.700374242293247 8.65000484720084e-08 -0.405919645349345 0.0378194076500925 MirTarget -0.234023009350349 0.000282322991762875 NA NA NA hsa-miR-106a-5p FZD3 0.67978010057847 0.00221925869726092 -0.405919645349345 0.0378194076500925 MirTarget;mirMAP;miRNATAP -0.11153753957119 0.00350111403434414 NA NA NA hsa-miR-142-3p FZD3 1.12754191614028 1.68798138028946e-08 -0.405919645349345 0.0378194076500925 miRanda -0.118512459580298 0.00483181300209284 NA NA NA hsa-miR-16-1-3p FZD3 0.955017760172879 5.95379292601146e-11 -0.405919645349345 0.0378194076500925 mirMAP -0.249215789471788 1.35563257853051e-05 NA NA NA hsa-miR-16-2-3p FZD3 1.1567130855258 1.01867256952189e-14 -0.405919645349345 0.0378194076500925 mirMAP -0.252327663922905 5.00557133337908e-06 NA NA NA hsa-miR-205-3p FZD3 1.2960640797621 5.80786479909147e-11 -0.405919645349345 0.0378194076500925 mirMAP -0.234932332851844 1.87444284032962e-08 25521201 Our data analysis also showed that miR-98 and miR-205 have two common predicted target genes FZD3 and RPS6KA3 which are actually genes associated with carcinoma according to the Online Mendelian Inheritance in Man OMIM database lung squamous cell cancer hsa-miR-205-5p FZD3 1.50759485376634 2.0003886738248e-16 -0.405919645349345 0.0378194076500925 MirTarget -0.250329887012726 1.99316269276153e-08 25521201 Our data analysis also showed that miR-98 and miR-205 have two common predicted target genes FZD3 and RPS6KA3 which are actually genes associated with carcinoma according to the Online Mendelian Inheritance in Man OMIM database lung squamous cell cancer hsa-miR-23a-3p FZD3 0.348231698801568 6.4911858506572e-05 -0.405919645349345 0.0378194076500925 MirTarget -0.371620292894839 0.000153714061322858 NA NA NA hsa-miR-23b-3p FZD3 -0.497563803223134 3.31483353357535e-05 -0.405919645349345 0.0378194076500925 MirTarget -0.269703040063802 0.000138913067017737 NA NA NA hsa-miR-27a-3p FZD3 0.348456440505425 0.00126682892514312 -0.405919645349345 0.0378194076500925 miRNATAP -0.34637741158127 1.08606674868051e-05 NA NA NA hsa-miR-27b-3p FZD3 -0.732682718863563 2.26896143573324e-09 -0.405919645349345 0.0378194076500925 miRNATAP -0.296138023529959 1.51707341048525e-05 NA NA NA hsa-miR-30e-3p FZD3 -0.890635378639789 1.65740480611339e-16 -0.405919645349345 0.0378194076500925 mirMAP -0.22355013875565 0.00371657463692107 NA NA NA hsa-let-7a-3p FZD4 0.0966652362351867 0.423761916840503 -0.815650187199159 4.38782163259962e-08 mirMAP -0.178911836594448 0.0010678781194651 NA NA NA hsa-let-7f-1-3p FZD4 0.700374242293247 8.65000484720084e-08 -0.815650187199159 4.38782163259962e-08 mirMAP -0.155969808971455 0.00173166560767719 NA NA NA hsa-let-7g-3p FZD4 0.637019243992294 0.000204623048574065 -0.815650187199159 4.38782163259962e-08 MirTarget;miRNATAP -0.130030558138227 0.00064027163524621 NA NA NA hsa-miR-106b-5p FZD4 0.50378717276868 1.45412404526866e-05 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.233594020061164 3.26917089168384e-05 NA NA NA hsa-miR-130b-3p FZD4 1.44628430084411 9.13980959861273e-24 -0.815650187199159 4.38782163259962e-08 mirMAP -0.166771411710335 0.000130645962717094 NA NA NA hsa-miR-141-3p FZD4 0.730011517758706 0.000120338355004032 -0.815650187199159 4.38782163259962e-08 TargetScan -0.384621226441373 1.35952134171499e-32 NA NA NA hsa-miR-15a-5p FZD4 0.783550182002274 2.60699595655907e-11 -0.815650187199159 4.38782163259962e-08 MirTarget -0.316046540857295 6.61530653664161e-09 NA NA NA hsa-miR-15b-5p FZD4 0.85315666454713 3.79816274836297e-12 -0.815650187199159 4.38782163259962e-08 MirTarget -0.292039381468361 2.00521102059024e-08 NA NA NA hsa-miR-16-5p FZD4 0.521122945828175 1.40561786410572e-06 -0.815650187199159 4.38782163259962e-08 MirTarget -0.275961233079746 4.81081238426063e-06 NA NA NA hsa-miR-17-3p FZD4 -0.0127974722290336 0.909559935689875 -0.815650187199159 4.38782163259962e-08 MirTarget -0.269009081400882 4.18669539260405e-06 NA NA NA hsa-miR-17-5p FZD4 1.41924888736771 2.75805544953758e-18 -0.815650187199159 4.38782163259962e-08 TargetScan -0.369785561579625 5.57763418816234e-23 NA NA NA hsa-miR-185-5p FZD4 0.675225177054909 1.84953949190805e-13 -0.815650187199159 4.38782163259962e-08 MirTarget -0.213487766584419 0.00252870771975344 NA NA NA hsa-miR-200b-3p FZD4 0.0717138787925347 0.682858087587209 -0.815650187199159 4.38782163259962e-08 mirMAP -0.359330121493523 1.53241321540023e-23 NA NA NA hsa-miR-200c-3p FZD4 0.630251054099546 0.000131975031451555 -0.815650187199159 4.38782163259962e-08 mirMAP -0.391980669668059 4.43258549593976e-25 NA NA NA hsa-miR-20a-5p FZD4 1.1531986665452 1.02385132917958e-11 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.333852681330871 9.51317386353706e-20 NA NA NA hsa-miR-21-5p FZD4 1.62465922021121 3.44191300985109e-58 -0.815650187199159 4.38782163259962e-08 mirMAP -0.287661271779748 6.60748558454114e-07 NA NA NA hsa-miR-224-3p FZD4 0.502645536188015 0.0081142387260641 -0.815650187199159 4.38782163259962e-08 MirTarget -0.24610422416118 5.21862603114631e-13 NA NA NA hsa-miR-25-3p FZD4 0.76549796417801 3.32282098247097e-11 -0.815650187199159 4.38782163259962e-08 mirMAP -0.22599947502801 5.38335232176849e-05 NA NA NA hsa-miR-27a-3p FZD4 0.348456440505425 0.00126682892514312 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.25207980206607 3.36726990710064e-05 NA NA NA hsa-miR-301a-3p FZD4 2.14132004241926 4.46255413526808e-25 -0.815650187199159 4.38782163259962e-08 mirMAP -0.20080802333307 1.3516795151641e-11 NA NA NA hsa-miR-3065-3p FZD4 -0.543069092777161 0.0213164885178151 -0.815650187199159 4.38782163259962e-08 mirMAP -0.128490062173461 3.29880151819197e-06 NA NA NA hsa-miR-324-3p FZD4 0.867391246413545 3.63808540490361e-10 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.219209977745863 2.46064329404204e-06 NA NA NA hsa-miR-33a-3p FZD4 0.20371038027126 0.212335697664505 -0.815650187199159 4.38782163259962e-08 mirMAP -0.186409384691855 4.5780850129921e-06 NA NA NA hsa-miR-3934-5p FZD4 1.48601805685912 2.33872147099905e-17 -0.815650187199159 4.38782163259962e-08 mirMAP -0.210225659786697 1.94482095129054e-08 NA NA NA hsa-miR-429 FZD4 0.559451508722375 0.00563641638673083 -0.815650187199159 4.38782163259962e-08 mirMAP -0.31150784766142 1.12702682090752e-23 NA NA NA hsa-miR-452-5p FZD4 0.373288744398455 0.0348485937209964 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.213842960151609 5.64707690350463e-09 NA NA NA hsa-miR-454-3p FZD4 1.54137391927201 4.15861570449376e-20 -0.815650187199159 4.38782163259962e-08 mirMAP -0.232233065555925 4.20909041882496e-10 NA NA NA hsa-miR-455-3p FZD4 2.68574446868387 4.28975903022818e-42 -0.815650187199159 4.38782163259962e-08 mirMAP -0.192283917018249 1.70384213598465e-10 NA NA NA hsa-miR-484 FZD4 0.918280909791707 1.39168306854263e-14 -0.815650187199159 4.38782163259962e-08 PITA -0.264573659753093 7.66896801931238e-07 NA NA NA hsa-miR-505-5p FZD4 1.25888458076414 7.80089782306577e-13 -0.815650187199159 4.38782163259962e-08 MirTarget -0.108971904868985 0.00288728768052822 NA NA NA hsa-miR-576-5p FZD4 0.940432050128373 6.90227595663302e-12 -0.815650187199159 4.38782163259962e-08 mirMAP -0.286203264705305 7.16334363231192e-10 NA NA NA hsa-miR-589-3p FZD4 1.59559692667315 6.2886410639161e-15 -0.815650187199159 4.38782163259962e-08 mirMAP -0.226897440559596 1.16405890096401e-12 NA NA NA hsa-miR-590-3p FZD4 0.221436901462551 0.0965904764063157 -0.815650187199159 4.38782163259962e-08 miRanda;mirMAP;miRNATAP -0.128296051181024 0.00961747396970288 NA NA NA hsa-miR-590-5p FZD4 0.763025362395968 3.65305892505623e-09 -0.815650187199159 4.38782163259962e-08 mirMAP -0.33154840046641 1.90546523558682e-11 NA NA NA hsa-miR-629-3p FZD4 1.43262037314105 2.37092217984413e-19 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.287336138379953 1.7789542370721e-13 NA NA NA hsa-miR-7-1-3p FZD4 1.13646121619622 1.49823237535933e-14 -0.815650187199159 4.38782163259962e-08 mirMAP -0.261549659988853 9.9088642742581e-10 NA NA NA hsa-miR-708-5p FZD4 1.54207894190626 2.2887257992285e-19 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.204286200127646 2.38415454136822e-08 NA NA NA hsa-miR-92a-3p FZD4 0.994679542307232 1.32587679156217e-16 -0.815650187199159 4.38782163259962e-08 mirMAP -0.483540442305307 4.09293149289207e-21 NA NA NA hsa-miR-92b-3p FZD4 0.869628761112414 4.71129204795212e-09 -0.815650187199159 4.38782163259962e-08 mirMAP -0.141432953081511 0.00120039067478519 NA NA NA hsa-miR-940 FZD4 1.25303020594374 1.3005368359451e-10 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.133815372372196 6.15164071025313e-05 NA NA NA hsa-miR-181a-2-3p FZD5 0.562132917934234 4.79313448225408e-05 -0.113485274622058 0.38590839547131 MirTarget -0.137692651649623 0.000777895527397809 NA NA NA hsa-miR-342-3p FZD5 0.99756868977753 9.28499866272332e-10 -0.113485274622058 0.38590839547131 PITA -0.114901171450085 0.000824922073740606 NA NA NA hsa-miR-369-3p FZD5 -1.2344419076994 2.66882944171146e-10 -0.113485274622058 0.38590839547131 MirTarget;PITA;miRNATAP -0.105032298373984 0.000244351098480649 NA NA NA hsa-miR-450b-5p FZD5 1.25529820885833 1.18847120528666e-15 -0.113485274622058 0.38590839547131 mirMAP -0.13961282239578 7.30218163652166e-05 NA NA NA hsa-miR-493-5p FZD5 -0.471586962917071 0.0221327433064002 -0.113485274622058 0.38590839547131 mirMAP -0.111501993784366 5.09909078182716e-05 NA NA NA hsa-miR-101-3p FZD6 -1.91263766544878 1.50270129259053e-39 0.959175728902371 7.16805044883792e-13 miRNAWalker2_validate;MirTarget -0.15236794370636 5.56147635006984e-05 NA NA NA hsa-miR-126-5p FZD6 -0.953529188793816 7.91719143295591e-16 0.959175728902371 7.16805044883792e-13 mirMAP;miRNATAP -0.18749347678421 0.000128934224548739 NA NA NA hsa-miR-139-5p FZD6 -1.46099200329485 7.85040381494472e-22 0.959175728902371 7.16805044883792e-13 miRanda -0.19666705958835 1.2956861634286e-07 NA NA NA hsa-miR-140-5p FZD6 -0.412389003031485 0.000136051708543369 0.959175728902371 7.16805044883792e-13 MirTarget;miRanda -0.299365048378534 4.2620559545244e-08 NA NA NA hsa-miR-19b-3p FZD6 0.538732279378089 0.000622008277870679 0.959175728902371 7.16805044883792e-13 MirTarget -0.119824221585792 0.00147978769330953 NA NA NA hsa-miR-142-3p FZD7 1.12754191614028 1.68798138028946e-08 -0.39549792326766 0.0891510942286115 miRanda -0.293214473864062 2.91121980676646e-09 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 0.288897753038094 0.0900009317815725 -0.39549792326766 0.0891510942286115 MirTarget;PITA;miRNATAP -0.365085958937664 5.02394453662511e-10 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-186-5p FZD7 0.353452958261612 0.000145058448579496 -0.39549792326766 0.0891510942286115 mirMAP -0.493097846846011 6.08851454307689e-06 NA NA NA hsa-miR-2355-5p FZD7 1.47205546931107 8.65192179636668e-19 -0.39549792326766 0.0891510942286115 MirTarget -0.420687622019341 2.978876488152e-13 NA NA NA hsa-miR-27a-3p FZD7 0.348456440505425 0.00126682892514312 -0.39549792326766 0.0891510942286115 MirTarget;miRNATAP -0.276163308720676 0.00335875166347624 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-338-3p FZD7 -0.948755228846395 8.99167125682392e-08 -0.39549792326766 0.0891510942286115 miRanda -0.294907171125007 1.36247903183051e-07 NA NA NA hsa-miR-486-5p FZD7 -1.70341092285685 6.64232609099498e-14 -0.39549792326766 0.0891510942286115 miRanda -0.122880076472061 0.00470368943387573 NA NA NA hsa-miR-590-3p FZD7 0.221436901462551 0.0965904764063157 -0.39549792326766 0.0891510942286115 miRanda -0.211484945411416 0.00564246232477888 NA NA NA hsa-miR-324-5p FZD8 1.66709479707179 1.45961450445769e-23 -0.204293317181818 0.303884935891493 miRanda -0.162530099857064 0.00104845391384164 NA NA NA hsa-miR-455-5p GDF5 1.408595672323 5.52039116456697e-22 -1.68166168499307 5.67237309755832e-07 miRanda;miRNATAP -0.503778917671206 1.7866026979293e-07 NA NA NA hsa-miR-590-5p GDF5 0.763025362395968 3.65305892505623e-09 -1.68166168499307 5.67237309755832e-07 miRanda -0.371936374707969 0.00100949445651432 NA NA NA hsa-miR-141-3p GDF6 0.730011517758706 0.000120338355004032 1.88833328676442 3.03419672063328e-08 TargetScan -0.281033139826599 0.000356822601212074 NA NA NA hsa-miR-141-5p GDF6 0.623874471326586 0.0018690552472983 1.88833328676442 3.03419672063328e-08 mirMAP -0.311373831850503 2.91162061460464e-05 NA NA NA hsa-miR-155-5p GDF6 0.533437622040649 0.00248671179205372 1.88833328676442 3.03419672063328e-08 miRNATAP -0.272371911410391 0.00137467212123933 NA NA NA hsa-miR-200b-3p GDF6 0.0717138787925347 0.682858087587209 1.88833328676442 3.03419672063328e-08 TargetScan -0.404991460069088 2.10512871731099e-06 NA NA NA hsa-miR-205-5p GDF6 1.50759485376634 2.0003886738248e-16 1.88833328676442 3.03419672063328e-08 miRNATAP -0.296165029968967 0.00019407979165439 NA NA NA hsa-miR-23b-5p GDF6 0.141208007066527 0.420202986869364 1.88833328676442 3.03419672063328e-08 miRNATAP -0.370338972992978 2.80532596265707e-05 NA NA NA hsa-miR-30d-3p GDF6 -0.577371911152798 2.02950840095287e-06 1.88833328676442 3.03419672063328e-08 miRNATAP -0.539386914122166 1.1579973321239e-05 NA NA NA hsa-miR-429 GDF6 0.559451508722375 0.00563641638673083 1.88833328676442 3.03419672063328e-08 PITA;miRanda;miRNATAP -0.235801484564826 0.00149595150430806 NA NA NA hsa-miR-590-3p GDF6 0.221436901462551 0.0965904764063157 1.88833328676442 3.03419672063328e-08 miRanda;mirMAP -0.354633670931517 0.00175694671792795 NA NA NA hsa-miR-142-3p GLI2 1.12754191614028 1.68798138028946e-08 0.414138373264684 0.191243526830277 miRanda -0.416858285404442 5.35534367625177e-10 NA NA NA hsa-miR-30c-5p GLI2 0.021222006155897 0.886366656528128 0.414138373264684 0.191243526830277 MirTarget -0.25831502202875 0.0056535170479409 NA NA NA hsa-miR-30e-5p GLI2 -1.02114836019762 6.81961221797866e-17 0.414138373264684 0.191243526830277 MirTarget -0.363652190664194 0.000925246004446185 NA NA NA hsa-miR-31-5p GLI2 2.79079137807505 1.72181058015659e-13 0.414138373264684 0.191243526830277 miRNAWalker2_validate -0.149778973208704 2.83682850457742e-05 NA NA NA hsa-miR-330-5p GLI2 0.944693925383906 5.04972895657346e-13 0.414138373264684 0.191243526830277 MirTarget -0.417151356839016 5.25086551433722e-05 NA NA NA hsa-miR-3607-3p GLI2 1.01377165357363 9.13355519701165e-05 0.414138373264684 0.191243526830277 miRNATAP -0.138273050538271 0.00905920415282999 NA NA NA hsa-miR-146b-5p GSK3B 0.917975986853978 3.33749259316025e-09 0.343238217842623 0.000162620715851218 miRanda -0.132473733778903 1.22425435698654e-07 NA NA NA hsa-miR-155-5p GSK3B 0.533437622040649 0.00248671179205372 0.343238217842623 0.000162620715851218 miRNAWalker2_validate;miRNATAP -0.129703405382586 5.34297193283262e-09 NA NA NA hsa-miR-181a-5p GSK3B 0.819060835827404 1.38616688310277e-13 0.343238217842623 0.000162620715851218 mirMAP -0.129983989338606 0.00022139654686707 NA NA NA hsa-miR-181c-5p GSK3B -0.168991199007857 0.196949106150297 0.343238217842623 0.000162620715851218 mirMAP -0.100996413243857 0.000916035275097975 NA NA NA hsa-miR-19b-3p GSK3B 0.538732279378089 0.000622008277870679 0.343238217842623 0.000162620715851218 mirMAP -0.150537422390616 1.39629849063498e-09 NA NA NA hsa-miR-26b-5p GSK3B -0.254478038884324 0.0285227763044636 0.343238217842623 0.000162620715851218 miRNATAP -0.183171373213342 7.56842885965509e-08 NA NA NA hsa-miR-29b-3p GSK3B -0.110721443686039 0.511264554091106 0.343238217842623 0.000162620715851218 miRTarBase;miRNATAP -0.15553953034104 2.18389788804596e-11 NA NA NA hsa-miR-30d-3p GSK3B -0.577371911152798 2.02950840095287e-06 0.343238217842623 0.000162620715851218 miRNATAP -0.131426620771029 5.32900605744827e-05 NA NA NA hsa-miR-320a GSK3B 0.801356001806321 4.91397101474502e-09 0.343238217842623 0.000162620715851218 miRanda;mirMAP -0.118878412659656 3.17737768709188e-05 NA NA NA hsa-miR-342-3p GSK3B 0.99756868977753 9.28499866272332e-10 0.343238217842623 0.000162620715851218 miRanda -0.148362741070108 3.75779017463144e-10 NA NA NA hsa-miR-362-5p GSK3B 0.41089772861323 0.0404254902071382 0.343238217842623 0.000162620715851218 miRNATAP -0.127816847863223 5.47709912360141e-11 NA NA NA hsa-miR-374a-5p GSK3B -0.621903385111545 6.61791773205282e-12 0.343238217842623 0.000162620715851218 mirMAP -0.147719372342419 0.000672011632138884 NA NA NA hsa-miR-374b-5p GSK3B -0.288413933608091 0.0041474558664058 0.343238217842623 0.000162620715851218 mirMAP -0.228003781574329 6.67084161350237e-09 NA NA NA hsa-miR-664a-3p GSK3B -0.256108763664991 0.0513188660751664 0.343238217842623 0.000162620715851218 mirMAP -0.163651290979419 5.20958641528547e-08 NA NA NA hsa-miR-100-5p ID1 -1.85857794619369 1.248973638996e-25 -0.0118696667498677 0.948751451722524 miRNAWalker2_validate -0.143877280213419 0.000820425868538338 NA NA NA hsa-miR-195-3p ID1 -0.624259620429699 0.000164279659144497 -0.0118696667498677 0.948751451722524 MirTarget;miRNATAP -0.125736398296229 0.00966307210383939 NA NA NA hsa-miR-215-5p ID1 -0.757663683237828 5.72998183244808e-05 -0.0118696667498677 0.948751451722524 miRNAWalker2_validate -0.1136940938684 0.0077492343359024 NA NA NA hsa-miR-29c-3p ID1 -2.08166260448948 8.3238369390898e-24 -0.0118696667498677 0.948751451722524 MirTarget -0.114315390258174 0.00202781763366418 NA NA NA hsa-miR-326 ID1 -0.425943992128769 0.0415010315530797 -0.0118696667498677 0.948751451722524 miRNATAP -0.236088132455653 5.31158656341608e-10 NA NA NA hsa-miR-330-3p ID1 -0.0524949332825773 0.719856123539461 -0.0118696667498677 0.948751451722524 PITA -0.192157137758586 0.000483613154635742 NA NA NA hsa-miR-331-3p ID1 0.906385914819361 4.27653809739414e-11 -0.0118696667498677 0.948751451722524 MirTarget -0.149149981793759 0.00957954979542548 NA NA NA hsa-miR-654-3p ID1 -1.77960431554497 1.76486415439529e-14 -0.0118696667498677 0.948751451722524 MirTarget;PITA;miRNATAP -0.171505005014403 2.79970458704026e-07 NA NA NA hsa-let-7a-3p ID2 0.0966652362351867 0.423761916840503 -0.66708976692791 0.000132355964462565 miRNATAP -0.219269752172642 0.000562753226413693 NA NA NA hsa-miR-19a-3p ID2 1.35800152353624 2.80940447111944e-12 -0.66708976692791 0.000132355964462565 MirTarget;miRNATAP -0.122329975433934 0.00146897453213979 NA NA NA hsa-miR-200c-3p ID2 0.630251054099546 0.000131975031451555 -0.66708976692791 0.000132355964462565 miRNATAP -0.13103869629721 0.00454971926162713 NA NA NA hsa-miR-27a-3p ID2 0.348456440505425 0.00126682892514312 -0.66708976692791 0.000132355964462565 MirTarget;miRNATAP -0.391039644371745 2.60290498448746e-08 NA NA NA hsa-miR-429 ID2 0.559451508722375 0.00563641638673083 -0.66708976692791 0.000132355964462565 PITA;miRanda;miRNATAP -0.123196121489444 0.00108202211097853 NA NA NA hsa-miR-455-3p ID2 2.68574446868387 4.28975903022818e-42 -0.66708976692791 0.000132355964462565 MirTarget;PITA;miRNATAP -0.162870476234884 4.09374487822784e-06 NA NA NA hsa-miR-429 ITGB2 0.559451508722375 0.00563641638673083 0.495688499293186 0.0192654248253241 miRanda -0.295915217409954 4.17687966019373e-11 NA NA NA hsa-let-7a-3p LATS1 0.0966652362351867 0.423761916840503 -0.187593699966823 0.292868004140907 MirTarget;mirMAP -0.356159017661076 2.57463684177605e-08 NA NA NA hsa-miR-103a-2-5p LATS1 1.37988337975616 6.74852943995612e-08 -0.187593699966823 0.292868004140907 MirTarget -0.296156326226757 4.60719940695564e-21 NA NA NA hsa-miR-103a-3p LATS1 0.556219385347418 1.55815736455067e-09 -0.187593699966823 0.292868004140907 miRNAWalker2_validate;MirTarget -0.249263709890109 0.00296290847726092 NA NA NA hsa-miR-10b-5p LATS1 -0.582989331935508 4.56688330655626e-06 -0.187593699966823 0.292868004140907 MirTarget -0.228249228056271 0.000166172343261332 NA NA NA hsa-miR-142-3p LATS1 1.12754191614028 1.68798138028946e-08 -0.187593699966823 0.292868004140907 MirTarget -0.113387124161094 0.00306697325631031 NA NA NA hsa-miR-15a-5p LATS1 0.783550182002274 2.60699595655907e-11 -0.187593699966823 0.292868004140907 MirTarget;miRNATAP -0.598493595957345 1.23725863655853e-21 NA NA NA hsa-miR-16-2-3p LATS1 1.1567130855258 1.01867256952189e-14 -0.187593699966823 0.292868004140907 mirMAP -0.29556914770567 3.4428617410706e-09 NA NA NA hsa-miR-181a-5p LATS1 0.819060835827404 1.38616688310277e-13 -0.187593699966823 0.292868004140907 MirTarget;miRNATAP -0.22979467011904 0.000836149376335107 NA NA NA hsa-miR-181b-5p LATS1 0.974255518824355 2.64876280203475e-16 -0.187593699966823 0.292868004140907 MirTarget;miRNATAP -0.183362543886711 0.00396194251216591 NA NA NA hsa-miR-188-5p LATS1 0.559328953885106 0.000430338888594543 -0.187593699966823 0.292868004140907 MirTarget -0.152266884889552 0.00184507714087844 NA NA NA hsa-miR-193a-3p LATS1 0.22120710726779 0.111827069464729 -0.187593699966823 0.292868004140907 miRanda -0.224772647645096 5.58609133591192e-05 NA NA NA hsa-miR-19b-1-5p LATS1 0.757034032029085 2.99828133413343e-07 -0.187593699966823 0.292868004140907 MirTarget -0.252818872755048 1.00775382895337e-06 NA NA NA hsa-miR-21-5p LATS1 1.62465922021121 3.44191300985109e-58 -0.187593699966823 0.292868004140907 miRNAWalker2_validate -0.219060981544406 0.00145392142629292 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-25-3p LATS1 0.76549796417801 3.32282098247097e-11 -0.187593699966823 0.292868004140907 miRNATAP -0.241010362824145 0.000271847825035702 NA NA NA hsa-miR-29a-5p LATS1 0.323252792625584 0.0370417231222825 -0.187593699966823 0.292868004140907 MirTarget -0.334802330606755 1.05674638523954e-11 NA NA NA hsa-miR-30d-3p LATS1 -0.577371911152798 2.02950840095287e-06 -0.187593699966823 0.292868004140907 mirMAP -0.253705010705251 6.47408280537114e-05 NA NA NA hsa-miR-320a LATS1 0.801356001806321 4.91397101474502e-09 -0.187593699966823 0.292868004140907 miRanda;miRNATAP -0.308372978710868 2.63471421681268e-08 NA NA NA hsa-miR-3607-3p LATS1 1.01377165357363 9.13355519701165e-05 -0.187593699966823 0.292868004140907 MirTarget -0.190297463179609 8.24540842082225e-11 NA NA NA hsa-miR-374b-5p LATS1 -0.288413933608091 0.0041474558664058 -0.187593699966823 0.292868004140907 mirMAP -0.417308157318981 5.76429583631734e-08 NA NA NA hsa-miR-429 LATS1 0.559451508722375 0.00563641638673083 -0.187593699966823 0.292868004140907 PITA;miRanda;miRNATAP -0.127967093903208 0.000824310196010881 NA NA NA hsa-miR-532-3p LATS1 0.80240056676907 1.08989551712617e-09 -0.187593699966823 0.292868004140907 MirTarget;miRNATAP -0.169454434572152 0.00362239066897663 NA NA NA hsa-miR-590-3p LATS1 0.221436901462551 0.0965904764063157 -0.187593699966823 0.292868004140907 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.159884919576599 0.00627758460819518 NA NA NA hsa-miR-590-5p LATS1 0.763025362395968 3.65305892505623e-09 -0.187593699966823 0.292868004140907 miRanda;miRNATAP -0.318453708612007 6.00808489219826e-08 NA NA NA hsa-miR-655-3p LATS1 -1.15004187025356 3.60771552708797e-07 -0.187593699966823 0.292868004140907 MirTarget -0.125556732718176 0.0003529136395105 NA NA NA hsa-miR-92a-3p LATS1 0.994679542307232 1.32587679156217e-16 -0.187593699966823 0.292868004140907 miRNATAP -0.274952566640417 1.11637529416316e-05 NA NA NA hsa-miR-103a-3p LATS2 0.556219385347418 1.55815736455067e-09 -0.376953577957516 0.00274675946799414 miRNATAP -0.36945008547401 2.69399259612685e-10 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-125a-5p LATS2 0.215366061934933 0.119550904549401 -0.376953577957516 0.00274675946799414 miRanda -0.11295149216472 0.00460112867374832 NA NA NA hsa-miR-130b-5p LATS2 1.77265255049999 1.43627774829684e-29 -0.376953577957516 0.00274675946799414 miRNATAP -0.224161838186385 5.00089965978922e-12 NA NA NA hsa-miR-15a-5p LATS2 0.783550182002274 2.60699595655907e-11 -0.376953577957516 0.00274675946799414 miRNATAP -0.388056056011073 3.65999286937939e-18 NA NA NA hsa-miR-15b-5p LATS2 0.85315666454713 3.79816274836297e-12 -0.376953577957516 0.00274675946799414 miRNATAP -0.306080400665483 1.26216324004128e-12 NA NA NA hsa-miR-16-5p LATS2 0.521122945828175 1.40561786410572e-06 -0.376953577957516 0.00274675946799414 miRNATAP -0.2490571434301 7.61190947194203e-07 NA NA NA hsa-miR-188-5p LATS2 0.559328953885106 0.000430338888594543 -0.376953577957516 0.00274675946799414 PITA -0.190227357062319 2.81839479038693e-08 NA NA NA hsa-miR-200b-3p LATS2 0.0717138787925347 0.682858087587209 -0.376953577957516 0.00274675946799414 TargetScan -0.310876096137294 2.86550958410531e-25 NA NA NA hsa-miR-200c-3p LATS2 0.630251054099546 0.000131975031451555 -0.376953577957516 0.00274675946799414 miRNATAP -0.24035014217479 1.31502672845278e-13 NA NA NA hsa-miR-25-3p LATS2 0.76549796417801 3.32282098247097e-11 -0.376953577957516 0.00274675946799414 miRNATAP -0.417642932798746 2.94462256834555e-20 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-27b-3p LATS2 -0.732682718863563 2.26896143573324e-09 -0.376953577957516 0.00274675946799414 miRNATAP -0.1151128860867 0.00950353441742885 NA NA NA hsa-miR-30c-5p LATS2 0.021222006155897 0.886366656528128 -0.376953577957516 0.00274675946799414 miRNATAP -0.328024382645738 5.5412859306841e-20 NA NA NA hsa-miR-30d-5p LATS2 -0.38399848121878 0.000171129616944749 -0.376953577957516 0.00274675946799414 miRNATAP -0.213512122257836 7.1706445787207e-05 NA NA NA hsa-miR-32-5p LATS2 -0.317310201890053 0.0102525324475293 -0.376953577957516 0.00274675946799414 miRNATAP -0.187032752201831 2.52300017875974e-05 NA NA NA hsa-miR-33a-3p LATS2 0.20371038027126 0.212335697664505 -0.376953577957516 0.00274675946799414 mirMAP -0.179375360696587 1.2020950082562e-07 NA NA NA hsa-miR-342-3p LATS2 0.99756868977753 9.28499866272332e-10 -0.376953577957516 0.00274675946799414 PITA;miRanda -0.202506496132895 6.21833144202412e-10 NA NA NA hsa-miR-361-5p LATS2 0.0803683277369505 0.314043140368058 -0.376953577957516 0.00274675946799414 miRanda -0.276365754087753 7.5737777288003e-05 NA NA NA hsa-miR-362-3p LATS2 -0.697212068252854 2.61718493418184e-06 -0.376953577957516 0.00274675946799414 PITA;miRanda -0.140554547476304 0.00013504428258678 NA NA NA hsa-miR-374b-5p LATS2 -0.288413933608091 0.0041474558664058 -0.376953577957516 0.00274675946799414 mirMAP -0.312661769779981 8.72479779224489e-09 NA NA NA hsa-miR-429 LATS2 0.559451508722375 0.00563641638673083 -0.376953577957516 0.00274675946799414 PITA;miRanda;miRNATAP -0.294322466236667 1.27581700006894e-30 NA NA NA hsa-miR-590-3p LATS2 0.221436901462551 0.0965904764063157 -0.376953577957516 0.00274675946799414 PITA;miRanda -0.195239729823722 2.0423088882998e-06 NA NA NA hsa-miR-92a-3p LATS2 0.994679542307232 1.32587679156217e-16 -0.376953577957516 0.00274675946799414 miRNATAP -0.411363789308702 7.11531726143982e-22 NA NA NA hsa-miR-93-5p LATS2 1.61042951896619 5.1280369606967e-24 -0.376953577957516 0.00274675946799414 miRNAWalker2_validate -0.357310369053873 1.55552278390747e-30 NA NA NA hsa-miR-96-5p LATS2 1.42326703011157 4.39736150032373e-14 -0.376953577957516 0.00274675946799414 miRNATAP -0.289191319281178 1.02153364425902e-26 NA NA NA hsa-let-7a-3p LEF1 0.0966652362351867 0.423761916840503 0.488266783568626 0.0110933059149055 miRNATAP -0.275840196352323 7.4673475039569e-05 NA NA NA hsa-miR-193b-3p LEF1 1.72788400801602 3.0722151264559e-21 0.488266783568626 0.0110933059149055 miRNAWalker2_validate -0.311745236740014 5.46005978515826e-13 NA NA NA hsa-miR-455-5p LEF1 1.408595672323 5.52039116456697e-22 0.488266783568626 0.0110933059149055 miRanda -0.211162394314959 0.000123308773316749 NA NA NA hsa-let-7a-3p LIMD1 0.0966652362351867 0.423761916840503 -0.452639000717659 3.57997315807277e-07 mirMAP -0.105458069418619 0.00117496979787369 NA NA NA hsa-miR-18a-5p LIMD1 1.65455873230328 3.76457892277775e-20 -0.452639000717659 3.57997315807277e-07 mirMAP -0.100844344477065 1.17020941995982e-06 NA NA NA hsa-miR-2355-5p LIMD1 1.47205546931107 8.65192179636668e-19 -0.452639000717659 3.57997315807277e-07 mirMAP -0.131981489004521 3.87456316949408e-09 NA NA NA hsa-miR-455-3p LIMD1 2.68574446868387 4.28975903022818e-42 -0.452639000717659 3.57997315807277e-07 miRNAWalker2_validate;mirMAP -0.108857084067595 1.26531511760145e-09 NA NA NA hsa-miR-146b-3p LLGL2 0.186534815310862 0.169137114997759 -1.02451772781869 2.41897640415207e-11 miRNATAP -0.239729448633178 1.700409850711e-06 NA NA NA hsa-miR-199a-3p LLGL2 -0.444218713278859 0.00182242576392808 -1.02451772781869 2.41897640415207e-11 PITA;miRNATAP -0.287061355469376 1.15475406163445e-09 NA NA NA hsa-miR-199b-3p LLGL2 -0.445649335808506 0.00178451574983478 -1.02451772781869 2.41897640415207e-11 PITA;miRNATAP -0.286467597808564 1.19190321887818e-09 NA NA NA hsa-miR-130b-3p MPP5 1.44628430084411 9.13980959861273e-24 -0.66105069147757 1.48685734474872e-12 miRNAWalker2_validate -0.182367448751588 1.85187368309232e-11 NA NA NA hsa-miR-140-5p MPP5 -0.412389003031485 0.000136051708543369 -0.66105069147757 1.48685734474872e-12 miRanda -0.130140245782959 0.000709546402759054 NA NA NA hsa-miR-155-5p MPP5 0.533437622040649 0.00248671179205372 -0.66105069147757 1.48685734474872e-12 miRNAWalker2_validate;MirTarget -0.120133199126731 2.49362867717843e-07 NA NA NA hsa-miR-16-2-3p MPP5 1.1567130855258 1.01867256952189e-14 -0.66105069147757 1.48685734474872e-12 MirTarget -0.143545943980367 8.84634366435666e-08 NA NA NA hsa-miR-181a-5p MPP5 0.819060835827404 1.38616688310277e-13 -0.66105069147757 1.48685734474872e-12 MirTarget -0.267200136707532 1.2233509784618e-13 NA NA NA hsa-miR-181b-5p MPP5 0.974255518824355 2.64876280203475e-16 -0.66105069147757 1.48685734474872e-12 MirTarget -0.199132208878321 3.12808762064854e-09 NA NA NA hsa-miR-181c-5p MPP5 -0.168991199007857 0.196949106150297 -0.66105069147757 1.48685734474872e-12 MirTarget -0.149958349454584 2.14186359299786e-06 NA NA NA hsa-miR-181d-5p MPP5 0.367649966373544 0.00537300571455306 -0.66105069147757 1.48685734474872e-12 MirTarget -0.207715451233482 1.92309441206999e-11 NA NA NA hsa-miR-199a-5p MPP5 -0.364835768178638 0.0435119211101981 -0.66105069147757 1.48685734474872e-12 MirTarget;PITA;miRanda;miRNATAP -0.124209057479831 4.713778962537e-08 NA NA NA hsa-miR-21-5p MPP5 1.62465922021121 3.44191300985109e-58 -0.66105069147757 1.48685734474872e-12 miRNAWalker2_validate -0.30361622753906 1.97772894575975e-17 NA NA NA hsa-miR-320a MPP5 0.801356001806321 4.91397101474502e-09 -0.66105069147757 1.48685734474872e-12 miRanda -0.129864325222402 1.32628763190705e-05 NA NA NA hsa-miR-576-5p MPP5 0.940432050128373 6.90227595663302e-12 -0.66105069147757 1.48685734474872e-12 PITA -0.112904424710319 0.000141795270115344 NA NA NA hsa-miR-590-5p MPP5 0.763025362395968 3.65305892505623e-09 -0.66105069147757 1.48685734474872e-12 miRanda -0.137320614749781 1.38349402115501e-05 NA NA NA hsa-miR-93-3p MPP5 1.69225547123293 1.50964095575087e-25 -0.66105069147757 1.48685734474872e-12 miRNAWalker2_validate -0.132724963472407 3.99058249010769e-08 NA NA NA hsa-let-7c-5p MYC -2.07953368242668 3.46048888391218e-23 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.107421906050131 0.000103545158346461 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-34a-5p MYC -0.117372471043915 0.364001947180738 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.157674637324898 0.000854501792660625 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-200b-3p NKD1 0.0717138787925347 0.682858087587209 0.725365278125643 0.00125463712045226 TargetScan -0.232568993512636 3.17464537813451e-05 NA NA NA hsa-miR-340-5p NKD1 -0.608415693437977 4.44345153563513e-05 0.725365278125643 0.00125463712045226 mirMAP -0.205337742152414 0.0017674712074584 NA NA NA hsa-miR-429 NKD1 0.559451508722375 0.00563641638673083 0.725365278125643 0.00125463712045226 miRanda;miRNATAP -0.131962362051135 0.00657248359023832 NA NA NA hsa-miR-455-5p PARD3 1.408595672323 5.52039116456697e-22 -0.660681569774532 6.66840976059654e-08 MirTarget;miRanda;miRNATAP -0.226138898565206 9.0417713284014e-11 NA NA NA hsa-miR-766-3p PARD3 1.07002176594541 8.2375790648059e-16 -0.660681569774532 6.66840976059654e-08 miRNAWalker2_validate -0.135129058920802 0.000619692997430813 NA NA NA hsa-miR-125a-3p PARD6A 0.116035800853173 0.444825559956959 -0.845901899170824 1.50727596531341e-05 miRanda -0.181711858176531 0.00133497913169926 NA NA NA hsa-miR-409-3p PARD6A -0.342347118512604 0.0538776384301546 -0.845901899170824 1.50727596531341e-05 miRNATAP -0.162892523351113 0.000738164932847718 NA NA NA hsa-let-7a-3p PARD6B 0.0966652362351867 0.423761916840503 -0.445418599908852 0.00406784698470121 MirTarget;miRNATAP -0.164444703965004 0.0035379322556658 NA NA NA hsa-let-7e-5p PARD6B 0.0857356192778891 0.512869729833211 -0.445418599908852 0.00406784698470121 MirTarget;miRNATAP -0.160847870330833 0.0019451322227473 NA NA NA hsa-let-7i-5p PARD6B 0.249440992451337 0.00426823922424972 -0.445418599908852 0.00406784698470121 MirTarget;miRNATAP -0.284663007246894 0.000274167906101794 NA NA NA hsa-miR-125a-3p PARD6B 0.116035800853173 0.444825559956959 -0.445418599908852 0.00406784698470121 MirTarget;miRanda -0.184949980615698 3.28016825438321e-05 NA NA NA hsa-miR-2355-3p PARD6B 1.58434563546762 4.06578912176206e-18 -0.445418599908852 0.00406784698470121 MirTarget;miRNATAP -0.136274410561769 0.000137370330402909 NA NA NA hsa-miR-369-3p PARD6B -1.2344419076994 2.66882944171146e-10 -0.445418599908852 0.00406784698470121 miRNATAP -0.211848293374324 3.01020353118723e-10 NA NA NA hsa-miR-381-3p PARD6B -2.21357103508055 2.33039447871705e-24 -0.445418599908852 0.00406784698470121 MirTarget -0.165355957263354 1.7814909743738e-08 NA NA NA hsa-miR-409-3p PARD6B -0.342347118512604 0.0538776384301546 -0.445418599908852 0.00406784698470121 PITA -0.245558437487011 5.89653509645463e-11 NA NA NA hsa-miR-411-5p PARD6B -2.13692124260403 3.56150106692251e-21 -0.445418599908852 0.00406784698470121 MirTarget -0.127636283316589 7.78697263767725e-06 NA NA NA hsa-miR-455-5p PARD6B 1.408595672323 5.52039116456697e-22 -0.445418599908852 0.00406784698470121 miRanda -0.221713735309056 5.12656544814491e-07 NA NA NA hsa-miR-493-5p PARD6B -0.471586962917071 0.0221327433064002 -0.445418599908852 0.00406784698470121 miRNATAP -0.206163877600049 1.88899712173421e-10 NA NA NA hsa-miR-146b-5p PARD6G 0.917975986853978 3.33749259316025e-09 0.0128286742879506 0.928718111108818 miRanda -0.14224349893926 0.000322826919439392 NA NA NA hsa-miR-655-3p PARD6G -1.15004187025356 3.60771552708797e-07 0.0128286742879506 0.928718111108818 MirTarget -0.142857683001639 3.52517228625602e-07 NA NA NA hsa-miR-107 PPP1CA -0.0447040564279497 0.671618791096755 0.244981142027021 0.00648644203224158 miRanda -0.140876259110232 0.000166130686988915 NA NA NA hsa-miR-125b-5p PPP1CA -0.993460109818276 5.07736727659894e-12 0.244981142027021 0.00648644203224158 miRTarBase -0.171774442632066 6.49031464075724e-11 25240408 MiR 125b promotes cell migration and invasion by targeting PPP1CA Rb signal pathways in gastric cancer resulting in a poor prognosis; MiR-125b was upregulated in gastric cancer tissues and cell lines and significantly promoted cellular proliferation migration and invasion by downregulating the expression of PPP1CA and upregulating Rb phosphorylation; MiR-125b functions as an oncogene by targeting downregulated PPP1CA and upregulated Rb phosphorylation in gastric cancer worse prognosis;cell migration gastric cancer hsa-miR-769-5p PPP1CA 0.0865819375213306 0.445395188017017 0.244981142027021 0.00648644203224158 miRNAWalker2_validate -0.131466977443034 0.00015183853828259 NA NA NA hsa-let-7a-3p PPP1CB 0.0966652362351867 0.423761916840503 -0.544364814530972 4.21333074611805e-12 mirMAP -0.128494111483556 8.46203452632047e-06 NA NA NA hsa-miR-140-5p PPP1CB -0.412389003031485 0.000136051708543369 -0.544364814530972 4.21333074611805e-12 miRanda -0.124134860307201 0.000115174321208332 NA NA NA hsa-miR-15b-5p PPP1CB 0.85315666454713 3.79816274836297e-12 -0.544364814530972 4.21333074611805e-12 miRNAWalker2_validate -0.124222274625243 7.4926124946533e-06 NA NA NA hsa-miR-16-2-3p PPP1CB 1.1567130855258 1.01867256952189e-14 -0.544364814530972 4.21333074611805e-12 mirMAP -0.138717504961623 6.00688691380838e-10 NA NA NA hsa-miR-181a-5p PPP1CB 0.819060835827404 1.38616688310277e-13 -0.544364814530972 4.21333074611805e-12 mirMAP;miRNATAP -0.219265453315969 4.35108251907339e-13 NA NA NA hsa-miR-181b-5p PPP1CB 0.974255518824355 2.64876280203475e-16 -0.544364814530972 4.21333074611805e-12 mirMAP;miRNATAP -0.201688391747777 5.5679021187782e-13 NA NA NA hsa-miR-181c-5p PPP1CB -0.168991199007857 0.196949106150297 -0.544364814530972 4.21333074611805e-12 mirMAP;miRNATAP -0.119449666946391 6.93827033860839e-06 NA NA NA hsa-miR-186-5p PPP1CB 0.353452958261612 0.000145058448579496 -0.544364814530972 4.21333074611805e-12 miRNATAP -0.201285094569138 6.78141065997042e-08 NA NA NA hsa-miR-320a PPP1CB 0.801356001806321 4.91397101474502e-09 -0.544364814530972 4.21333074611805e-12 miRNATAP -0.157181716078229 2.17425703120908e-10 NA NA NA hsa-miR-374b-5p PPP1CB -0.288413933608091 0.0041474558664058 -0.544364814530972 4.21333074611805e-12 mirMAP -0.169565589052004 9.54692958656028e-07 NA NA NA hsa-miR-450b-5p PPP1CB 1.25529820885833 1.18847120528666e-15 -0.544364814530972 4.21333074611805e-12 miRNATAP -0.113896037865295 1.04623271342832e-07 NA NA NA hsa-miR-455-5p PPP1CB 1.408595672323 5.52039116456697e-22 -0.544364814530972 4.21333074611805e-12 PITA;miRanda -0.10970538607125 1.4046124026361e-06 NA NA NA hsa-miR-505-3p PPP1CB 0.912823669571645 4.0549774967148e-13 -0.544364814530972 4.21333074611805e-12 miRNAWalker2_validate -0.180503308042427 1.32967401642187e-11 NA NA NA hsa-miR-542-3p PPP1CB 0.643308814904977 8.81635403230104e-07 -0.544364814530972 4.21333074611805e-12 miRNATAP -0.134001054563535 3.26658937208594e-07 NA NA NA hsa-miR-590-3p PPP1CB 0.221436901462551 0.0965904764063157 -0.544364814530972 4.21333074611805e-12 PITA;miRanda;mirMAP -0.11361315424731 1.35137453035304e-05 NA NA NA hsa-miR-7-1-3p PPP1CB 1.13646121619622 1.49823237535933e-14 -0.544364814530972 4.21333074611805e-12 mirMAP -0.123117230297691 6.42741480950657e-08 NA NA NA hsa-miR-664a-3p PPP2CA -0.256108763664991 0.0513188660751664 -0.157094072613604 0.0267322811415248 mirMAP -0.106852242976453 4.77000247252727e-06 NA NA NA hsa-miR-421 PPP2CB 0.945488088619653 2.35762398527362e-09 -0.476022792153769 4.06003367022085e-09 miRNAWalker2_validate;miRanda -0.112192501866666 3.84022796644551e-07 NA NA NA hsa-miR-15b-5p PPP2R1B 0.85315666454713 3.79816274836297e-12 -0.214632147370702 0.032287082704768 MirTarget -0.131544236138784 0.000158748224069463 NA NA NA hsa-miR-30b-5p PPP2R1B -0.400238605368173 0.00346540992719245 -0.214632147370702 0.032287082704768 miRNATAP -0.135040929585792 2.08942951526129e-05 NA NA NA hsa-miR-409-3p PPP2R2A -0.342347118512604 0.0538776384301546 -0.701426942627148 1.05994742317374e-13 PITA -0.103751074240992 1.06323112728475e-05 NA NA NA hsa-miR-450b-5p PPP2R2A 1.25529820885833 1.18847120528666e-15 -0.701426942627148 1.05994742317374e-13 PITA;mirMAP -0.15863049314045 7.04501375156165e-10 NA NA NA hsa-miR-192-5p PPP2R2C 0.380924502586635 0.00986961967409205 0.627078703832598 0.0593896690297092 mirMAP -0.648126510682995 1.97333354822272e-11 NA NA NA hsa-miR-194-5p PPP2R2C -0.0214221838459805 0.872940154118701 0.627078703832598 0.0593896690297092 miRNATAP -0.907089755050328 8.18992632359146e-18 NA NA NA hsa-miR-218-5p PPP2R2C -1.0725338636959 3.61493686604269e-09 0.627078703832598 0.0593896690297092 miRNATAP -0.43028514665884 3.20067951268789e-08 NA NA NA hsa-miR-320a PPP2R2C 0.801356001806321 4.91397101474502e-09 0.627078703832598 0.0593896690297092 MirTarget;PITA;miRanda;miRNATAP -0.550044064334242 1.12818840549332e-07 NA NA NA hsa-miR-320b PPP2R2C 1.23473838180754 3.04337566045537e-14 0.627078703832598 0.0593896690297092 MirTarget;PITA;miRanda;miRNATAP -0.417995504247863 1.33082038645399e-06 NA NA NA hsa-miR-374b-5p PPP2R2C -0.288413933608091 0.0041474558664058 0.627078703832598 0.0593896690297092 miRNATAP -0.817690113646295 1.20840421733783e-08 NA NA NA hsa-miR-502-3p PPP2R2C -0.165138869760313 0.106881047403914 0.627078703832598 0.0593896690297092 MirTarget;PITA;miRNATAP -0.476590393248363 0.000839374168886682 NA NA NA hsa-miR-590-3p PPP2R2C 0.221436901462551 0.0965904764063157 0.627078703832598 0.0593896690297092 miRanda -0.383550194744054 0.000436242415531753 NA NA NA hsa-miR-625-5p PPP2R2C 0.346770617079364 0.02860843739549 0.627078703832598 0.0593896690297092 MirTarget -0.767831126020108 8.73562906211157e-18 NA NA NA hsa-miR-140-3p PPP2R2D -0.967453553824782 7.6999446305445e-23 0.229961518994137 0.000399861225691009 mirMAP -0.144936617380545 1.35289109138347e-07 NA NA NA hsa-miR-140-3p PRKCI -0.967453553824782 7.6999446305445e-23 0.292711236284172 0.00258969610346621 PITA -0.206525580534023 5.6004889318062e-07 NA NA NA hsa-miR-146b-5p PRKCI 0.917975986853978 3.33749259316025e-09 0.292711236284172 0.00258969610346621 MirTarget;miRanda -0.107147902472116 6.51281052770767e-05 NA NA NA hsa-miR-155-5p PRKCI 0.533437622040649 0.00248671179205372 0.292711236284172 0.00258969610346621 miRNAWalker2_validate -0.105374421006605 9.85855202028185e-06 NA NA NA hsa-miR-186-5p PRKCI 0.353452958261612 0.000145058448579496 0.292711236284172 0.00258969610346621 MirTarget;mirMAP;miRNATAP -0.172393443484473 0.000160583511087528 NA NA NA hsa-miR-365a-3p PRKCI 0.446833934952926 0.00233857759218299 0.292711236284172 0.00258969610346621 MirTarget -0.207646819311477 1.85752187544661e-13 NA NA NA hsa-miR-664a-3p PRKCI -0.256108763664991 0.0513188660751664 0.292711236284172 0.00258969610346621 mirMAP -0.156464310546975 1.10309645495777e-06 NA NA NA hsa-miR-148a-3p PRKCZ -0.428944290834563 0.00954246923521465 0.0108886897944149 0.919407727590057 MirTarget -0.113754550356634 5.23075400512978e-05 NA NA NA hsa-miR-148b-3p PRKCZ 0.386859166050437 4.6728211830726e-06 0.0108886897944149 0.919407727590057 MirTarget -0.188548425016115 0.000691912593616517 NA NA NA hsa-miR-152-3p PRKCZ -0.382486223604156 0.00710736505198702 0.0108886897944149 0.919407727590057 MirTarget -0.147731321952872 6.39689169129248e-06 NA NA NA hsa-miR-744-5p RASSF1 0.436098372735845 0.000850400989351181 0.00285478368132441 0.978255545134834 miRNAWalker2_validate -0.26433223459779 6.88963464002493e-15 NA NA NA hsa-miR-130a-3p RASSF6 0.67051191119964 4.89747518735144e-06 -0.678883652358939 0.00369056819933583 mirMAP -0.371170506596265 6.04794749119583e-08 NA NA NA hsa-miR-17-5p RASSF6 1.41924888736771 2.75805544953758e-18 -0.678883652358939 0.00369056819933583 mirMAP -0.322546860018309 8.20451312582504e-08 NA NA NA hsa-miR-182-5p RASSF6 1.15060905311096 6.25565852529946e-10 -0.678883652358939 0.00369056819933583 mirMAP -0.139618191840114 0.00979994358656273 NA NA NA hsa-miR-20a-5p RASSF6 1.1531986665452 1.02385132917958e-11 -0.678883652358939 0.00369056819933583 mirMAP -0.310802198651371 1.1075063283184e-07 NA NA NA hsa-miR-29b-1-5p RASSF6 1.39669186711325 4.36960953138935e-11 -0.678883652358939 0.00369056819933583 mirMAP -0.142536159893335 0.00261034293886983 NA NA NA hsa-miR-301a-3p RASSF6 2.14132004241926 4.46255413526808e-25 -0.678883652358939 0.00369056819933583 mirMAP -0.203901840378545 1.28982076855254e-05 NA NA NA hsa-miR-339-5p RASSF6 1.07771430326938 2.45772601859307e-09 -0.678883652358939 0.00369056819933583 miRanda -0.246642544368353 8.49577255766092e-06 NA NA NA hsa-miR-454-3p RASSF6 1.54137391927201 4.15861570449376e-20 -0.678883652358939 0.00369056819933583 mirMAP -0.267254143602326 4.55125979344119e-06 NA NA NA hsa-miR-655-3p RASSF6 -1.15004187025356 3.60771552708797e-07 -0.678883652358939 0.00369056819933583 MirTarget -0.148593997291825 0.00133152835836027 NA NA NA hsa-miR-92a-3p RASSF6 0.994679542307232 1.32587679156217e-16 -0.678883652358939 0.00369056819933583 mirMAP -0.359356116635277 1.28775425342851e-05 NA NA NA hsa-miR-93-5p RASSF6 1.61042951896619 5.1280369606967e-24 -0.678883652358939 0.00369056819933583 mirMAP -0.189523106335282 0.00197717164545495 NA NA NA hsa-miR-103a-3p SAV1 0.556219385347418 1.55815736455067e-09 0.0658782567865561 0.458921016968059 miRNAWalker2_validate -0.186559571111276 6.88145428852159e-06 NA NA NA hsa-miR-186-5p SAV1 0.353452958261612 0.000145058448579496 0.0658782567865561 0.458921016968059 mirMAP -0.143721905064717 0.00056233565846526 NA NA NA hsa-miR-664a-3p SAV1 -0.256108763664991 0.0513188660751664 0.0658782567865561 0.458921016968059 mirMAP -0.111810366921781 0.000142248843527074 NA NA NA hsa-miR-148a-3p SERPINE1 -0.428944290834563 0.00954246923521465 2.9800460155055 1.19587534601183e-23 miRNATAP -0.588614974561901 2.12257805079507e-13 NA NA NA hsa-miR-148a-5p SERPINE1 -1.00478606532747 1.38045244999229e-07 2.9800460155055 1.19587534601183e-23 miRNATAP -0.483536967493396 2.33591419513461e-12 NA NA NA hsa-miR-30a-5p SERPINE1 -1.79779915425811 1.93360169837799e-26 2.9800460155055 1.19587534601183e-23 miRNATAP -0.538352757158472 6.00868327349311e-13 NA NA NA hsa-miR-30b-5p SERPINE1 -0.400238605368173 0.00346540992719245 2.9800460155055 1.19587534601183e-23 MirTarget -0.571395507493692 5.43373687267357e-09 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 0.021222006155897 0.886366656528128 2.9800460155055 1.19587534601183e-23 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.436659380942926 1.62646729429929e-06 NA NA NA hsa-miR-30d-5p SERPINE1 -0.38399848121878 0.000171129616944749 2.9800460155055 1.19587534601183e-23 miRNATAP -0.990118259600798 2.80475112753928e-14 NA NA NA hsa-miR-34a-5p SERPINE1 -0.117372471043915 0.364001947180738 2.9800460155055 1.19587534601183e-23 miRNATAP -0.695579360286566 1.94417698929934e-11 NA NA NA hsa-miR-378a-5p SERPINE1 -1.31095692407946 2.375328908085e-15 2.9800460155055 1.19587534601183e-23 MirTarget -0.818100657001554 3.87528348811537e-27 NA NA NA hsa-miR-769-5p SERPINE1 0.0865819375213306 0.445395188017017 2.9800460155055 1.19587534601183e-23 MirTarget;miRNATAP -0.464940639629924 0.000108602547545672 NA NA NA hsa-miR-942-5p SERPINE1 0.678652135586536 2.58063518495056e-07 2.9800460155055 1.19587534601183e-23 MirTarget -0.302350801947272 0.00309769215152792 NA NA NA hsa-miR-99a-5p SERPINE1 -2.344442285007 7.11841214134739e-24 2.9800460155055 1.19587534601183e-23 miRNAWalker2_validate -0.641238698328427 6.18498189813307e-35 NA NA NA hsa-miR-26b-5p SMAD1 -0.254478038884324 0.0285227763044636 -0.0539132448202961 0.553158711912491 MirTarget -0.110304184591212 0.00121600102844096 25761878;27027434 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1;Twist1 related miR 26b 5p suppresses epithelial mesenchymal transition migration and invasion by targeting SMAD1 in hepatocellular carcinoma; Subsequent investigation revealed that miR-26b-5p directly inhibited SMAD family member 1 SMAD1 expression; miR-26b-5p repressed BMP4/Smad1 signaling following SMAD1 inhibition; Overexpression of SMAD1 reversed the function of miR-26b-5p; In human HCC tissues and mouse xenograft tumors miR-26b-5p levels were inversely correlated with SMAD1 expression as well as metastasis; miR-26b-5p suppresses Twist1-induced EMT invasion and metastasis of HCC cells by targeting SMAD1 and BMP4/Smad1 signaling ;metastasis sarcoma;liver cancer hsa-let-7a-3p SMAD2 0.0966652362351867 0.423761916840503 0.0243635060778491 0.76464000338556 mirMAP -0.120201003720566 4.00233873380995e-05 NA NA NA hsa-miR-181a-5p SMAD2 0.819060835827404 1.38616688310277e-13 0.0243635060778491 0.76464000338556 mirMAP -0.123663686344939 7.35992784180675e-05 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 0.974255518824355 2.64876280203475e-16 0.0243635060778491 0.76464000338556 mirMAP -0.187179272190298 4.69209630284474e-11 NA NA NA hsa-miR-455-5p SMAD2 1.408595672323 5.52039116456697e-22 0.0243635060778491 0.76464000338556 miRanda -0.146407779382659 1.44497506412449e-10 NA NA NA hsa-miR-145-5p SMAD3 -0.46917511594055 0.000685297625493134 -0.143490080047147 0.241618109620266 MirTarget;miRNATAP -0.115484614688291 0.00271929213208624 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 0.533437622040649 0.00248671179205372 -0.143490080047147 0.241618109620266 miRNAWalker2_validate -0.125492484204873 2.91075561128582e-05 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-186-5p SMAD3 0.353452958261612 0.000145058448579496 -0.143490080047147 0.241618109620266 mirMAP -0.183402338959526 0.00144579229064042 NA NA NA hsa-miR-424-5p SMAD3 1.48125289532143 9.10372985713165e-19 -0.143490080047147 0.241618109620266 MirTarget -0.158147445199969 2.11197443864582e-07 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-let-7a-3p SMAD4 0.0966652362351867 0.423761916840503 -0.429721565372713 9.05223747485839e-07 mirMAP -0.127673799060679 6.14893432718486e-05 NA NA NA hsa-miR-130a-3p SMAD4 0.67051191119964 4.89747518735144e-06 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRNATAP -0.144664759620316 1.85930895184609e-08 NA NA NA hsa-miR-18a-5p SMAD4 1.65455873230328 3.76457892277775e-20 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate -0.132804055287407 4.94433335605224e-11 NA NA NA hsa-miR-19a-3p SMAD4 1.35800152353624 2.80940447111944e-12 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.111631809114141 5.01550217662971e-09 NA NA NA hsa-miR-21-3p SMAD4 1.25126438776674 2.4124216716282e-17 -0.429721565372713 9.05223747485839e-07 mirMAP -0.132998757674157 1.0204793984454e-07 NA NA NA hsa-miR-224-5p SMAD4 1.94534596857416 1.88348779207332e-19 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.104382574165612 6.63646727576293e-10 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-2355-5p SMAD4 1.47205546931107 8.65192179636668e-19 -0.429721565372713 9.05223747485839e-07 MirTarget -0.198974232428425 2.21498106355127e-20 NA NA NA hsa-miR-27a-3p SMAD4 0.348456440505425 0.00126682892514312 -0.429721565372713 9.05223747485839e-07 MirTarget -0.157382002902766 9.11244451316926e-06 NA NA NA hsa-miR-450b-5p SMAD4 1.25529820885833 1.18847120528666e-15 -0.429721565372713 9.05223747485839e-07 mirMAP -0.113363230314613 1.66484502341078e-06 NA NA NA hsa-miR-454-3p SMAD4 1.54137391927201 4.15861570449376e-20 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRNATAP -0.107809125022266 8.27427228720796e-07 NA NA NA hsa-miR-576-5p SMAD4 0.940432050128373 6.90227595663302e-12 -0.429721565372713 9.05223747485839e-07 mirMAP -0.137995054888109 4.27825973334458e-07 NA NA NA hsa-miR-590-5p SMAD4 0.763025362395968 3.65305892505623e-09 -0.429721565372713 9.05223747485839e-07 miRanda -0.107285938961663 0.000249372347039553 NA NA NA hsa-miR-106b-5p SMAD7 0.50378717276868 1.45412404526866e-05 0.469997710527323 8.21513951765723e-05 miRNATAP -0.163422646030292 0.000263635907927213 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-15b-5p SMAD7 0.85315666454713 3.79816274836297e-12 0.469997710527323 8.21513951765723e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.136898986568294 0.00105146347402388 NA NA NA hsa-miR-200b-3p SMAD7 0.0717138787925347 0.682858087587209 0.469997710527323 8.21513951765723e-05 TargetScan;mirMAP -0.190829778453809 7.93994002729443e-11 NA NA NA hsa-miR-20a-5p SMAD7 1.1531986665452 1.02385132917958e-11 0.469997710527323 8.21513951765723e-05 miRNATAP -0.100089615235679 0.000914946768445574 NA NA NA hsa-miR-25-3p SMAD7 0.76549796417801 3.32282098247097e-11 0.469997710527323 8.21513951765723e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.166835984507603 0.000179739799814254 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer colon cancer hsa-miR-32-5p SMAD7 -0.317310201890053 0.0102525324475293 0.469997710527323 8.21513951765723e-05 MirTarget;miRNATAP -0.121074613232041 0.00430825372322111 NA NA NA hsa-miR-324-3p SMAD7 0.867391246413545 3.63808540490361e-10 0.469997710527323 8.21513951765723e-05 MirTarget -0.116948967805168 0.00167093296013716 NA NA NA hsa-miR-34a-5p SMAD7 -0.117372471043915 0.364001947180738 0.469997710527323 8.21513951765723e-05 MirTarget -0.150176449131751 0.000210288978076299 NA NA NA hsa-miR-590-5p SMAD7 0.763025362395968 3.65305892505623e-09 0.469997710527323 8.21513951765723e-05 MirTarget;PITA;miRanda;miRNATAP -0.125559244828915 0.00166132967657345 NA NA NA hsa-miR-92a-3p SMAD7 0.994679542307232 1.32587679156217e-16 0.469997710527323 8.21513951765723e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.154291690631016 0.000259667555596049 NA NA NA hsa-miR-93-5p SMAD7 1.61042951896619 5.1280369606967e-24 0.469997710527323 8.21513951765723e-05 miRNATAP -0.104542339030373 0.000839336392470791 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-107 SNAI2 -0.0447040564279497 0.671618791096755 1.57363779849313 5.91219248669788e-24 miRanda -0.284005615551857 2.80975142738815e-05 NA NA NA hsa-miR-126-5p SNAI2 -0.953529188793816 7.91719143295591e-16 1.57363779849313 5.91219248669788e-24 MirTarget -0.28956153342037 6.59691839147703e-07 NA NA NA hsa-miR-140-5p SNAI2 -0.412389003031485 0.000136051708543369 1.57363779849313 5.91219248669788e-24 miRanda -0.309663243070182 2.27741612376817e-06 25322669;27597739 Down regulation of miR 140 induces EMT and promotes invasion by targeting Slug in esophageal cancer; Slug a target gene of miR-140 was examined by luciferase assay and Western blot; miR-140 may regulate the cell invasion of EC via controlling Slug expression;Mechanistically Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA ceRNA for miR-140-5p to de-repress the expression of the target gene Slug ; esophageal cancer;liver cancer hsa-miR-148b-3p SNAI2 0.386859166050437 4.6728211830726e-06 1.57363779849313 5.91219248669788e-24 miRNAWalker2_validate -0.281196118743247 0.000887546987344902 NA NA NA hsa-miR-200b-3p SNAI2 0.0717138787925347 0.682858087587209 1.57363779849313 5.91219248669788e-24 TargetScan -0.308386885932541 7.03084214359139e-15 NA NA NA hsa-miR-200c-3p SNAI2 0.630251054099546 0.000131975031451555 1.57363779849313 5.91219248669788e-24 miRNATAP -0.134398114048252 0.00174621077363836 NA NA NA hsa-miR-330-3p SNAI2 -0.0524949332825773 0.719856123539461 1.57363779849313 5.91219248669788e-24 PITA -0.130033682964608 0.00780041280539171 NA NA NA hsa-miR-335-3p SNAI2 0.336785882180547 0.0542446207938138 1.57363779849313 5.91219248669788e-24 mirMAP -0.144963210468707 0.000354960857720622 NA NA NA hsa-miR-33a-3p SNAI2 0.20371038027126 0.212335697664505 1.57363779849313 5.91219248669788e-24 MirTarget -0.157829857169527 0.000355518332647255 NA NA NA hsa-miR-375 SNAI2 -4.24070205340868 7.48368361454041e-28 1.57363779849313 5.91219248669788e-24 miRanda -0.176728059166066 8.36927466430417e-27 NA NA NA hsa-miR-429 SNAI2 0.559451508722375 0.00563641638673083 1.57363779849313 5.91219248669788e-24 PITA;miRanda;miRNATAP -0.175312757486467 4.8083188190211e-07 NA NA NA hsa-miR-532-5p SNAI2 -0.021857649390892 0.830992272120134 1.57363779849313 5.91219248669788e-24 PITA -0.470416294863014 8.75387306864013e-12 NA NA NA hsa-miR-9-5p SNAI2 1.65694862043766 2.08325802567323e-05 1.57363779849313 5.91219248669788e-24 miRNAWalker2_validate -0.155442431965235 6.55014524540304e-19 NA NA NA hsa-miR-139-5p SOX2 -1.46099200329485 7.85040381494472e-22 -0.117268050444232 0.761680418807291 miRanda -0.331600378877449 0.00179958409063984 NA NA NA hsa-miR-369-3p SOX2 -1.2344419076994 2.66882944171146e-10 -0.117268050444232 0.761680418807291 PITA;miRNATAP -0.305245854514815 0.000314245444199847 NA NA NA hsa-miR-450a-5p SOX2 1.74695686398479 4.62583996044297e-22 -0.117268050444232 0.761680418807291 miRNATAP -0.510701876741138 6.92764091663196e-09 NA NA NA hsa-miR-450b-5p SOX2 1.25529820885833 1.18847120528666e-15 -0.117268050444232 0.761680418807291 PITA;miRNATAP -0.460102572486722 9.54513588263103e-06 26845645 miR 450b 5p Suppresses Stemness and the Development of Chemoresistance by Targeting SOX2 in Colorectal Cancer; Mechanistically we found that miR-450b-5p directly targeted SOX2 an essential factor in stem cells; Expression of miR-450b-5p was negatively correlated to the expression of SOX2 the percentages of CD133+ cells present and sphere-forming capacity in CRC cells; Finally depletion of SOX2 abolished the effects of suppression of miR-450b-5p on stemness and chemoresistance in HT29 cells drug resistance colorectal cancer hsa-miR-455-5p SOX2 1.408595672323 5.52039116456697e-22 -0.117268050444232 0.761680418807291 miRanda -0.705258622533785 9.5262918469778e-11 NA NA NA hsa-miR-493-5p SOX2 -0.471586962917071 0.0221327433064002 -0.117268050444232 0.761680418807291 miRNATAP -0.223712917007172 0.00621525820569428 NA NA NA hsa-miR-140-5p STK3 -0.412389003031485 0.000136051708543369 0.798407094188578 1.68871676946511e-21 PITA;miRanda -0.176514898218827 4.23113809950716e-07 NA NA NA hsa-miR-29b-2-5p STK3 -0.502720326849742 0.000730448246894952 0.798407094188578 1.68871676946511e-21 MirTarget -0.129610585580681 2.82448960909338e-07 NA NA NA hsa-miR-24-2-5p TCF7L2 1.27293931700635 4.48240091510596e-15 -0.121670934720171 0.187175353769128 MirTarget -0.109017447605775 5.05328253504215e-06 NA NA NA hsa-miR-576-5p TCF7L2 0.940432050128373 6.90227595663302e-12 -0.121670934720171 0.187175353769128 mirMAP -0.109067218424977 0.000139070321050089 NA NA NA hsa-let-7a-3p TEAD1 0.0966652362351867 0.423761916840503 -0.5818299762395 5.12187205160228e-06 MirTarget -0.145224044293324 0.00184177825279049 NA NA NA hsa-miR-103a-3p TEAD1 0.556219385347418 1.55815736455067e-09 -0.5818299762395 5.12187205160228e-06 mirMAP -0.241130773892409 6.40645524499648e-05 NA NA NA hsa-miR-130a-3p TEAD1 0.67051191119964 4.89747518735144e-06 -0.5818299762395 5.12187205160228e-06 mirMAP -0.111205885947518 0.00337583747272739 NA NA NA hsa-miR-141-3p TEAD1 0.730011517758706 0.000120338355004032 -0.5818299762395 5.12187205160228e-06 mirMAP -0.234723627009324 1.92495315215995e-16 NA NA NA hsa-miR-146b-5p TEAD1 0.917975986853978 3.33749259316025e-09 -0.5818299762395 5.12187205160228e-06 PITA;miRanda -0.118491287941844 0.00086271614681384 NA NA NA hsa-miR-16-1-3p TEAD1 0.955017760172879 5.95379292601146e-11 -0.5818299762395 5.12187205160228e-06 MirTarget;mirMAP -0.134968622524909 0.000351244525833208 NA NA NA hsa-miR-16-2-3p TEAD1 1.1567130855258 1.01867256952189e-14 -0.5818299762395 5.12187205160228e-06 mirMAP -0.171751978715288 2.24370164308249e-06 NA NA NA hsa-miR-17-5p TEAD1 1.41924888736771 2.75805544953758e-18 -0.5818299762395 5.12187205160228e-06 mirMAP -0.191755134385167 5.56826845342999e-09 NA NA NA hsa-miR-182-5p TEAD1 1.15060905311096 6.25565852529946e-10 -0.5818299762395 5.12187205160228e-06 mirMAP;miRNATAP -0.191772252568095 4.56493180146358e-11 NA NA NA hsa-miR-186-5p TEAD1 0.353452958261612 0.000145058448579496 -0.5818299762395 5.12187205160228e-06 MirTarget -0.195126177087322 0.00126222506586851 NA NA NA hsa-miR-19a-3p TEAD1 1.35800152353624 2.80940447111944e-12 -0.5818299762395 5.12187205160228e-06 mirMAP -0.216115159560291 3.83780505315035e-15 NA NA NA hsa-miR-19b-3p TEAD1 0.538732279378089 0.000622008277870679 -0.5818299762395 5.12187205160228e-06 mirMAP -0.258941004840655 8.57017502903317e-14 NA NA NA hsa-miR-200a-3p TEAD1 0.607140814457753 0.00289840524858752 -0.5818299762395 5.12187205160228e-06 mirMAP -0.214299540327419 9.38020223459079e-16 NA NA NA hsa-miR-200a-5p TEAD1 0.701063526850019 0.000188402923774663 -0.5818299762395 5.12187205160228e-06 miRNATAP -0.130123139540135 1.05056063675525e-05 NA NA NA hsa-miR-200b-3p TEAD1 0.0717138787925347 0.682858087587209 -0.5818299762395 5.12187205160228e-06 TargetScan -0.182103566313072 8.3001918285966e-09 NA NA NA hsa-miR-200c-3p TEAD1 0.630251054099546 0.000131975031451555 -0.5818299762395 5.12187205160228e-06 miRNATAP -0.169022820959683 4.73478778992858e-07 NA NA NA hsa-miR-205-5p TEAD1 1.50759485376634 2.0003886738248e-16 -0.5818299762395 5.12187205160228e-06 miRNATAP -0.205823200389355 1.41338363401611e-12 NA NA NA hsa-miR-20a-5p TEAD1 1.1531986665452 1.02385132917958e-11 -0.5818299762395 5.12187205160228e-06 mirMAP -0.209848102182837 4.57758387283039e-11 NA NA NA hsa-miR-224-3p TEAD1 0.502645536188015 0.0081142387260641 -0.5818299762395 5.12187205160228e-06 mirMAP -0.167326392837384 1.15638480120168e-08 NA NA NA hsa-miR-224-5p TEAD1 1.94534596857416 1.88348779207332e-19 -0.5818299762395 5.12187205160228e-06 mirMAP -0.150049171612356 1.19829975222817e-09 NA NA NA hsa-miR-25-3p TEAD1 0.76549796417801 3.32282098247097e-11 -0.5818299762395 5.12187205160228e-06 miRNATAP -0.218520651623415 4.39584823933827e-06 NA NA NA hsa-miR-29b-2-5p TEAD1 -0.502720326849742 0.000730448246894952 -0.5818299762395 5.12187205160228e-06 MirTarget -0.106627259457861 0.00455000303896864 NA NA NA hsa-miR-29b-3p TEAD1 -0.110721443686039 0.511264554091106 -0.5818299762395 5.12187205160228e-06 mirMAP -0.160590074950113 1.19501182356776e-06 NA NA NA hsa-miR-301a-3p TEAD1 2.14132004241926 4.46255413526808e-25 -0.5818299762395 5.12187205160228e-06 mirMAP -0.151288123801546 2.6993916467702e-09 NA NA NA hsa-miR-320a TEAD1 0.801356001806321 4.91397101474502e-09 -0.5818299762395 5.12187205160228e-06 miRNAWalker2_validate;mirMAP -0.147444095366319 0.00025607754873891 NA NA NA hsa-miR-3607-3p TEAD1 1.01377165357363 9.13355519701165e-05 -0.5818299762395 5.12187205160228e-06 miRNATAP -0.104666922362407 9.14779837251488e-07 NA NA NA hsa-miR-425-5p TEAD1 0.931027421598738 6.46235724408844e-08 -0.5818299762395 5.12187205160228e-06 mirMAP -0.141694882714459 9.36097203461641e-06 NA NA NA hsa-miR-429 TEAD1 0.559451508722375 0.00563641638673083 -0.5818299762395 5.12187205160228e-06 PITA;miRNATAP -0.199065832932605 1.85973376540592e-13 NA NA NA hsa-miR-454-3p TEAD1 1.54137391927201 4.15861570449376e-20 -0.5818299762395 5.12187205160228e-06 mirMAP -0.21857859258558 4.30453922806901e-12 NA NA NA hsa-miR-505-3p TEAD1 0.912823669571645 4.0549774967148e-13 -0.5818299762395 5.12187205160228e-06 mirMAP -0.131602712769628 0.00257596407111146 NA NA NA hsa-miR-576-5p TEAD1 0.940432050128373 6.90227595663302e-12 -0.5818299762395 5.12187205160228e-06 mirMAP -0.250545568472576 2.35880283024048e-10 NA NA NA hsa-miR-590-3p TEAD1 0.221436901462551 0.0965904764063157 -0.5818299762395 5.12187205160228e-06 MirTarget;PITA;miRanda;miRNATAP -0.123933597222637 0.00331021742679258 NA NA NA hsa-miR-664a-3p TEAD1 -0.256108763664991 0.0513188660751664 -0.5818299762395 5.12187205160228e-06 mirMAP -0.211982908477803 5.8921189484168e-07 NA NA NA hsa-miR-7-1-3p TEAD1 1.13646121619622 1.49823237535933e-14 -0.5818299762395 5.12187205160228e-06 mirMAP -0.118364217935579 0.00135943852486692 NA NA NA hsa-miR-708-3p TEAD1 1.32647174389322 4.87465491977979e-16 -0.5818299762395 5.12187205160228e-06 mirMAP -0.111747466424083 0.000780401314767773 NA NA NA hsa-miR-92a-3p TEAD1 0.994679542307232 1.32587679156217e-16 -0.5818299762395 5.12187205160228e-06 miRNATAP -0.226669552178887 4.81223706175391e-07 NA NA NA hsa-miR-93-5p TEAD1 1.61042951896619 5.1280369606967e-24 -0.5818299762395 5.12187205160228e-06 mirMAP -0.235863121151443 7.90644006234113e-13 NA NA NA hsa-miR-96-5p TEAD1 1.42326703011157 4.39736150032373e-14 -0.5818299762395 5.12187205160228e-06 TargetScan;miRNATAP -0.21652597750963 1.92286730726871e-14 NA NA NA hsa-let-7d-5p TEAD3 0.481757661442508 3.66030810124939e-07 -0.134718661848333 0.0961692225683811 miRNATAP -0.175164416823643 2.00039468218688e-06 NA NA NA hsa-let-7g-5p TEAD3 -0.250780249469264 0.00939610188330072 -0.134718661848333 0.0961692225683811 miRNATAP -0.157462481909596 1.63701284247373e-05 NA NA NA hsa-let-7i-5p TEAD3 0.249440992451337 0.00426823922424972 -0.134718661848333 0.0961692225683811 miRNATAP -0.159691153460762 8.30060041539863e-05 NA NA NA hsa-miR-139-5p TGFB1 -1.46099200329485 7.85040381494472e-22 1.63261254184582 2.57292771878501e-37 miRanda -0.211396728970549 1.66114173348681e-08 NA NA NA hsa-miR-29b-3p TGFB1 -0.110721443686039 0.511264554091106 1.63261254184582 2.57292771878501e-37 miRTarBase -0.115557141630177 0.00118189427407973 NA NA NA hsa-miR-141-3p TGFB2 0.730011517758706 0.000120338355004032 0.0777328362726655 0.723018455166753 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.265467824704804 8.27771461885267e-08 NA NA NA hsa-miR-142-3p TGFB2 1.12754191614028 1.68798138028946e-08 0.0777328362726655 0.723018455166753 miRNATAP -0.16064296699396 0.000634225971259789 NA NA NA hsa-miR-149-5p TGFB2 0.443278770827687 0.0642022866136881 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.224915548613611 1.07874560543081e-08 NA NA NA hsa-miR-200a-3p TGFB2 0.607140814457753 0.00289840524858752 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.245845232906061 1.05145500844554e-07 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 0.0441399794719697 0.880456392176704 0.0777328362726655 0.723018455166753 MirTarget -0.213491686707761 2.34238525013733e-11 NA NA NA hsa-miR-29b-3p TGFB2 -0.110721443686039 0.511264554091106 0.0777328362726655 0.723018455166753 miRTarBase;MirTarget;miRNATAP -0.160451483561471 0.00470479835294533 NA NA NA hsa-miR-33a-3p TGFB2 0.20371038027126 0.212335697664505 0.0777328362726655 0.723018455166753 MirTarget;mirMAP -0.284781670411935 1.38897599512622e-06 NA NA NA hsa-miR-362-5p TGFB2 0.41089772861323 0.0404254902071382 0.0777328362726655 0.723018455166753 MirTarget -0.221176820672115 2.86666724884053e-06 NA NA NA hsa-miR-429 TGFB2 0.559451508722375 0.00563641638673083 0.0777328362726655 0.723018455166753 miRNATAP -0.213199102441814 5.30129859548984e-06 NA NA NA hsa-miR-454-3p TGFB2 1.54137391927201 4.15861570449376e-20 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.160741300174909 0.00334509150397591 NA NA NA hsa-miR-500a-5p TGFB2 0.675401699376111 8.24389004707854e-05 0.0777328362726655 0.723018455166753 mirMAP -0.159447320526312 0.00397529568273535 NA NA NA hsa-miR-500b-5p TGFB2 0.674875511637057 8.39602242688137e-05 0.0777328362726655 0.723018455166753 MirTarget -0.160233047874767 0.00378717200794635 NA NA NA hsa-miR-589-3p TGFB2 1.59559692667315 6.2886410639161e-15 0.0777328362726655 0.723018455166753 MirTarget -0.123357495887196 0.00914033095581057 NA NA NA hsa-miR-590-5p TGFB2 0.763025362395968 3.65305892505623e-09 0.0777328362726655 0.723018455166753 miRanda;miRNATAP -0.342026904103455 2.39104051032236e-06 NA NA NA hsa-miR-944 TGFB2 1.47323925060177 2.61626403984929e-13 0.0777328362726655 0.723018455166753 mirMAP -0.166241708180204 0.000315071117627543 NA NA NA hsa-let-7a-3p TGFB3 0.0966652362351867 0.423761916840503 1.00893266823856 2.40088713170131e-07 MirTarget -0.216799599468632 0.00248516203461445 NA NA NA hsa-miR-26b-3p TGFB3 0.421575313079363 0.00223298166810883 1.00893266823856 2.40088713170131e-07 MirTarget -0.227871116558054 0.000253998125314173 NA NA NA hsa-miR-29b-3p TGFB3 -0.110721443686039 0.511264554091106 1.00893266823856 2.40088713170131e-07 miRTarBase -0.233447034464102 4.45758973897005e-06 NA NA NA hsa-miR-590-3p TGFB3 0.221436901462551 0.0965904764063157 1.00893266823856 2.40088713170131e-07 miRanda -0.212001265861609 0.00106335445516084 NA NA NA hsa-miR-629-3p TGFB3 1.43262037314105 2.37092217984413e-19 1.00893266823856 2.40088713170131e-07 MirTarget -0.176865315949139 0.000694496344538885 NA NA NA hsa-miR-101-3p TGFBR1 -1.91263766544878 1.50270129259053e-39 0.615617809402788 1.98384557846381e-08 miRNAWalker2_validate;miRNATAP -0.137242751276775 7.52092687571314e-06 NA NA NA hsa-miR-101-5p TGFBR1 -1.429324744941 4.00032662184937e-18 0.615617809402788 1.98384557846381e-08 mirMAP -0.133177319619643 2.37858441571769e-06 NA NA NA hsa-miR-125b-5p TGFBR1 -0.993460109818276 5.07736727659894e-12 0.615617809402788 1.98384557846381e-08 miRNATAP -0.15777834540882 1.45852749097952e-06 NA NA NA hsa-miR-181c-5p TGFBR1 -0.168991199007857 0.196949106150297 0.615617809402788 1.98384557846381e-08 mirMAP;miRNATAP -0.10421464495814 0.0049760261835319 NA NA NA hsa-miR-200b-3p TGFBR1 0.0717138787925347 0.682858087587209 0.615617809402788 1.98384557846381e-08 mirMAP -0.197410832791802 2.77510960964195e-13 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-361-5p TGFBR1 0.0803683277369505 0.314043140368058 0.615617809402788 1.98384557846381e-08 miRanda;mirMAP;miRNATAP -0.161140636642561 0.00903876484470876 NA NA NA hsa-miR-374a-5p TGFBR1 -0.621903385111545 6.61791773205282e-12 0.615617809402788 1.98384557846381e-08 mirMAP -0.162078010547043 0.00217725764527797 NA NA NA hsa-miR-374b-5p TGFBR1 -0.288413933608091 0.0041474558664058 0.615617809402788 1.98384557846381e-08 mirMAP -0.207273863828956 1.67941177062955e-05 NA NA NA hsa-miR-429 TGFBR1 0.559451508722375 0.00563641638673083 0.615617809402788 1.98384557846381e-08 miRanda;miRNATAP -0.155570000352315 3.37635898013511e-11 NA NA NA hsa-miR-664a-3p TGFBR1 -0.256108763664991 0.0513188660751664 0.615617809402788 1.98384557846381e-08 mirMAP -0.200405898397308 4.18541096888924e-08 NA NA NA hsa-miR-106a-5p TGFBR2 0.67978010057847 0.00221925869726092 -0.433829718000188 0.0135145061644855 miRTarBase;miRNATAP -0.255393044945105 2.71545223274384e-14 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 0.50378717276868 1.45412404526866e-05 -0.433829718000188 0.0135145061644855 miRNATAP -0.545456782286389 1.33851981046724e-17 NA NA NA hsa-miR-130a-3p TGFBR2 0.67051191119964 4.89747518735144e-06 -0.433829718000188 0.0135145061644855 miRNATAP -0.233720846507776 5.92987815592498e-06 NA NA NA hsa-miR-130b-3p TGFBR2 1.44628430084411 9.13980959861273e-24 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.390455313786453 4.03477020820313e-15 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 1.41924888736771 2.75805544953758e-18 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.420579241358807 7.61600448040271e-22 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 1.65455873230328 3.76457892277775e-20 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate -0.322639732975004 6.25654643349646e-16 NA NA NA hsa-miR-19a-3p TGFBR2 1.35800152353624 2.80940447111944e-12 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.341667968021617 4.33453479376719e-20 NA NA NA hsa-miR-19b-3p TGFBR2 0.538732279378089 0.000622008277870679 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.466136413197791 1.17242031237057e-23 NA NA NA hsa-miR-20a-5p TGFBR2 1.1531986665452 1.02385132917958e-11 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRTarBase;miRNATAP -0.433886761312993 1.28958621534827e-24 NA NA NA hsa-miR-20b-5p TGFBR2 0.345967670847176 0.232014828043601 -0.433829718000188 0.0135145061644855 miRNATAP -0.203374864266804 3.23250679695954e-15 NA NA NA hsa-miR-23b-3p TGFBR2 -0.497563803223134 3.31483353357535e-05 -0.433829718000188 0.0135145061644855 miRNATAP -0.203411673528942 0.00142820710804535 NA NA NA hsa-miR-29b-2-5p TGFBR2 -0.502720326849742 0.000730448246894952 -0.433829718000188 0.0135145061644855 mirMAP -0.208499831431345 4.6618592916398e-05 NA NA NA hsa-miR-301a-3p TGFBR2 2.14132004241926 4.46255413526808e-25 -0.433829718000188 0.0135145061644855 miRNATAP -0.231775665365658 2.20860839363543e-11 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320a TGFBR2 0.801356001806321 4.91397101474502e-09 -0.433829718000188 0.0135145061644855 miRanda;miRNATAP -0.347747831358455 1.70608718391257e-10 NA NA NA hsa-miR-320b TGFBR2 1.23473838180754 3.04337566045537e-14 -0.433829718000188 0.0135145061644855 miRanda;miRNATAP -0.303558439833062 1.8858687275721e-11 NA NA NA hsa-miR-335-3p TGFBR2 0.336785882180547 0.0542446207938138 -0.433829718000188 0.0135145061644855 mirMAP -0.291745913178869 1.21540724972883e-11 NA NA NA hsa-miR-335-5p TGFBR2 -1.17227779671552 1.49282618530733e-10 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate -0.121435164126501 0.00315771117150945 NA NA NA hsa-miR-33a-3p TGFBR2 0.20371038027126 0.212335697664505 -0.433829718000188 0.0135145061644855 mirMAP -0.268664607255719 1.22612921559662e-08 NA NA NA hsa-miR-429 TGFBR2 0.559451508722375 0.00563641638673083 -0.433829718000188 0.0135145061644855 miRNATAP -0.414910311589602 2.47671709912537e-31 NA NA NA hsa-miR-454-3p TGFBR2 1.54137391927201 4.15861570449376e-20 -0.433829718000188 0.0135145061644855 miRNATAP -0.288586727900927 2.48780685732294e-11 NA NA NA hsa-miR-501-3p TGFBR2 0.820141346319976 1.74562930463389e-08 -0.433829718000188 0.0135145061644855 TargetScan -0.265130761383748 2.90088382530096e-07 NA NA NA hsa-miR-590-3p TGFBR2 0.221436901462551 0.0965904764063157 -0.433829718000188 0.0135145061644855 miRanda -0.150913065440851 0.00899478950557185 NA NA NA hsa-miR-590-5p TGFBR2 0.763025362395968 3.65305892505623e-09 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.455277845669355 1.52135226951358e-15 NA NA NA hsa-miR-9-5p TGFBR2 1.65694862043766 2.08325802567323e-05 -0.433829718000188 0.0135145061644855 miRNATAP -0.233380460659898 5.34358412799493e-38 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 0.994679542307232 1.32587679156217e-16 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate -0.667598178448999 5.42081269693353e-30 NA NA NA hsa-miR-93-5p TGFBR2 1.61042951896619 5.1280369606967e-24 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.511432433288783 2.71776456002482e-32 NA NA NA hsa-let-7a-3p TP53BP2 0.0966652362351867 0.423761916840503 0.00876907903187885 0.919812093138469 mirMAP -0.114978441781946 0.000249837693775027 NA NA NA hsa-miR-22-5p TP53BP2 0.706731861922839 3.44318705980007e-07 0.00876907903187885 0.919812093138469 miRNATAP -0.134160071701189 5.7072761657574e-07 NA NA NA hsa-miR-127-5p TP73 -0.605739525751187 0.000636065602565634 0.727032903213249 2.81060475543339e-05 mirMAP -0.19376328921949 5.23307827135341e-06 NA NA NA hsa-miR-22-3p TP73 0.00776313533473072 0.926356548861307 0.727032903213249 2.81060475543339e-05 mirMAP -0.373630323632164 4.70784221173934e-05 NA NA NA hsa-miR-378a-3p WNT10A -1.50453783521372 9.41694954361173e-17 0.912234934100313 0.00299229216637372 MirTarget;miRNATAP -0.196810924541095 0.00626452857856093 NA NA NA hsa-miR-378c WNT10A -1.82618708894602 7.26454201089171e-22 0.912234934100313 0.00299229216637372 MirTarget;miRNATAP -0.214084791496156 0.00157458296095885 NA NA NA hsa-miR-320b WNT11 1.23473838180754 3.04337566045537e-14 -0.224750666322645 0.510626012221646 miRanda -0.270316259616059 0.0024603931714496 NA NA NA hsa-miR-429 WNT11 0.559451508722375 0.00563641638673083 -0.224750666322645 0.510626012221646 miRNATAP -0.209942515620557 0.00424611523018706 NA NA NA hsa-miR-590-3p WNT11 0.221436901462551 0.0965904764063157 -0.224750666322645 0.510626012221646 miRanda -0.501468167000306 6.77947598913954e-06 NA NA NA hsa-miR-146b-3p WNT16 0.186534815310862 0.169137114997759 -0.572594284105154 0.0847579131877057 MirTarget -0.378579455076714 0.000401262636265055 NA NA NA hsa-miR-181a-5p WNT16 0.819060835827404 1.38616688310277e-13 -0.572594284105154 0.0847579131877057 miRNAWalker2_validate;MirTarget -0.403564170104319 0.00167256717496098 NA NA NA hsa-miR-181b-5p WNT16 0.974255518824355 2.64876280203475e-16 -0.572594284105154 0.0847579131877057 MirTarget -0.455875596880539 0.000117206606772003 NA NA NA hsa-miR-139-5p WNT2 -1.46099200329485 7.85040381494472e-22 3.55309052838923 1.0938033286164e-22 miRanda -0.690199764489526 1.59848261634154e-11 NA NA NA hsa-miR-361-3p WNT2 0.272298288982435 0.0147874880476998 3.55309052838923 1.0938033286164e-22 MirTarget -0.431764780233256 0.00366253988360293 NA NA NA hsa-miR-362-3p WNT2 -0.697212068252854 2.61718493418184e-06 3.55309052838923 1.0938033286164e-22 miRanda -0.527767916132786 1.67420691006025e-06 NA NA NA hsa-miR-532-5p WNT2 -0.021857649390892 0.830992272120134 3.55309052838923 1.0938033286164e-22 miRNATAP -0.480782556995644 0.00315250264690939 NA NA NA hsa-miR-590-3p WNT2 0.221436901462551 0.0965904764063157 3.55309052838923 1.0938033286164e-22 miRanda;mirMAP -0.366105059605095 0.00323658686598995 NA NA NA hsa-miR-624-5p WNT2 -0.229389464626096 0.110488966509615 3.55309052838923 1.0938033286164e-22 MirTarget -0.448629777504243 9.83335360340784e-05 NA NA NA hsa-miR-125a-3p WNT2B 0.116035800853173 0.444825559956959 0.857364992918016 0.00177791017742915 miRanda -0.306887893905702 0.000102594071214014 NA NA NA hsa-miR-130a-3p WNT2B 0.67051191119964 4.89747518735144e-06 0.857364992918016 0.00177791017742915 MirTarget -0.231837953960532 0.00433670996478201 NA NA NA hsa-miR-186-5p WNT2B 0.353452958261612 0.000145058448579496 0.857364992918016 0.00177791017742915 mirMAP -0.502293042756746 0.000102724799757724 NA NA NA hsa-miR-576-5p WNT2B 0.940432050128373 6.90227595663302e-12 0.857364992918016 0.00177791017742915 mirMAP -0.256334036782699 0.00286460593846409 NA NA NA hsa-miR-135b-5p WNT3 1.5570143078477 4.60753610971455e-13 0.498299440798017 0.0228069128506682 MirTarget -0.143238430697911 0.000931984076340095 NA NA NA hsa-miR-146a-5p WNT3 -0.0201236699646614 0.905882759106561 0.498299440798017 0.0228069128506682 MirTarget -0.243184121621581 1.38485802464774e-05 NA NA NA hsa-miR-146b-5p WNT3 0.917975986853978 3.33749259316025e-09 0.498299440798017 0.0228069128506682 MirTarget;PITA;miRanda;miRNATAP -0.170568796363283 0.00496324388141207 NA NA NA hsa-miR-192-5p WNT3 0.380924502586635 0.00986961967409205 0.498299440798017 0.0228069128506682 miRNAWalker2_validate -0.222711795902267 0.000567479502332092 NA NA NA hsa-miR-215-5p WNT3 -0.757663683237828 5.72998183244808e-05 0.498299440798017 0.0228069128506682 miRNAWalker2_validate -0.165315446096867 0.0011006520087949 NA NA NA hsa-miR-107 WNT4 -0.0447040564279497 0.671618791096755 0.155343533272991 0.546942165628682 PITA;miRNATAP -0.442918090382549 3.50237250623185e-05 NA NA NA hsa-let-7a-3p WNT5A 0.0966652362351867 0.423761916840503 0.230244489186426 0.276036125068596 miRNATAP -0.236393902681147 0.00203160512009966 NA NA NA hsa-miR-142-3p WNT5A 1.12754191614028 1.68798138028946e-08 0.230244489186426 0.276036125068596 miRanda -0.170207296882227 0.000170819602841971 NA NA NA hsa-miR-155-5p WNT5A 0.533437622040649 0.00248671179205372 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.292461135450501 1.33940668925285e-08 NA NA NA hsa-miR-15b-3p WNT5A 1.05020782493504 6.38723677324836e-14 0.230244489186426 0.276036125068596 mirMAP -0.175165295991482 0.00645298447676834 NA NA NA hsa-miR-16-2-3p WNT5A 1.1567130855258 1.01867256952189e-14 0.230244489186426 0.276036125068596 MirTarget;mirMAP -0.335972431523505 1.53488293667871e-08 NA NA NA hsa-miR-16-5p WNT5A 0.521122945828175 1.40561786410572e-06 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.370382454158463 1.19067012660461e-05 NA NA NA hsa-miR-186-5p WNT5A 0.353452958261612 0.000145058448579496 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP;miRNATAP -0.450879801993129 5.17906690047651e-06 NA NA NA hsa-miR-205-3p WNT5A 1.2960640797621 5.80786479909147e-11 0.230244489186426 0.276036125068596 mirMAP -0.146584017158563 0.00129989170721468 NA NA NA hsa-miR-26b-5p WNT5A -0.254478038884324 0.0285227763044636 0.230244489186426 0.276036125068596 mirMAP;miRNATAP -0.280915259189257 0.00040737667148347 NA NA NA hsa-miR-29a-5p WNT5A 0.323252792625584 0.0370417231222825 0.230244489186426 0.276036125068596 mirMAP -0.260976602260308 1.01644561078111e-05 NA NA NA hsa-miR-30a-3p WNT5A -2.26144364746452 8.12421214153823e-31 0.230244489186426 0.276036125068596 mirMAP -0.118105642486288 0.00756898976025631 NA NA NA hsa-miR-30a-5p WNT5A -1.79779915425811 1.93360169837799e-26 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.17873480778717 0.000544504752065439 NA NA NA hsa-miR-30b-5p WNT5A -0.400238605368173 0.00346540992719245 0.230244489186426 0.276036125068596 mirMAP -0.382501092288541 8.72466565087115e-09 NA NA NA hsa-miR-30c-5p WNT5A 0.021222006155897 0.886366656528128 0.230244489186426 0.276036125068596 mirMAP -0.315278604382802 3.20061386526904e-07 NA NA NA hsa-miR-30d-3p WNT5A -0.577371911152798 2.02950840095287e-06 0.230244489186426 0.276036125068596 mirMAP -0.330966437618027 1.06807407622655e-05 NA NA NA hsa-miR-30e-3p WNT5A -0.890635378639789 1.65740480611339e-16 0.230244489186426 0.276036125068596 mirMAP -0.32558124534923 8.6493574536442e-05 NA NA NA hsa-miR-30e-5p WNT5A -1.02114836019762 6.81961221797866e-17 0.230244489186426 0.276036125068596 mirMAP -0.302477702909968 3.39614513198558e-05 NA NA NA hsa-miR-330-5p WNT5A 0.944693925383906 5.04972895657346e-13 0.230244489186426 0.276036125068596 miRanda -0.29230342849594 2.09572746719721e-05 NA NA NA hsa-miR-374b-5p WNT5A -0.288413933608091 0.0041474558664058 0.230244489186426 0.276036125068596 MirTarget;miRNATAP -0.304076813996518 0.000947733080358778 NA NA NA hsa-miR-576-5p WNT5A 0.940432050128373 6.90227595663302e-12 0.230244489186426 0.276036125068596 mirMAP -0.285474332440034 1.36168151290682e-05 NA NA NA hsa-miR-582-5p WNT5A -0.0366995972742474 0.821827119138923 0.230244489186426 0.276036125068596 miRNATAP -0.165827000654824 0.00340576037437022 NA NA NA hsa-miR-590-3p WNT5A 0.221436901462551 0.0965904764063157 0.230244489186426 0.276036125068596 miRanda;mirMAP;miRNATAP -0.250968399301464 0.000285345561598827 NA NA NA hsa-miR-7-1-3p WNT5A 1.13646121619622 1.49823237535933e-14 0.230244489186426 0.276036125068596 mirMAP -0.288658318926048 1.72502648080357e-06 NA NA NA hsa-miR-92a-3p WNT5A 0.994679542307232 1.32587679156217e-16 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.244964920046973 0.00100835732123874 NA NA NA hsa-miR-185-5p WNT5B 0.675225177054909 1.84953949190805e-13 -0.860090527376287 0.000559437189686941 miRNAWalker2_validate -0.304303496296371 0.00959861548970579 NA NA NA hsa-miR-339-5p WNT5B 1.07771430326938 2.45772601859307e-09 -0.860090527376287 0.000559437189686941 miRanda -0.15836635732466 0.00779539351118663 NA NA NA hsa-miR-107 WNT7A -0.0447040564279497 0.671618791096755 2.17548841896822 1.27532651052268e-07 MirTarget;miRanda -0.704639231015142 4.76998312512393e-05 NA NA NA hsa-miR-15b-5p WNT7A 0.85315666454713 3.79816274836297e-12 2.17548841896822 1.27532651052268e-07 MirTarget -0.690990899099695 1.72630444936178e-06 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-16-5p WNT7A 0.521122945828175 1.40561786410572e-06 2.17548841896822 1.27532651052268e-07 MirTarget -0.727661930163233 1.31515331894387e-05 NA NA NA hsa-miR-195-5p WNT7A -1.8367376818177 6.9944883988895e-31 2.17548841896822 1.27532651052268e-07 MirTarget -0.420405764359272 8.98560350756301e-05 NA NA NA hsa-miR-361-5p WNT7A 0.0803683277369505 0.314043140368058 2.17548841896822 1.27532651052268e-07 MirTarget;PITA;miRanda -0.891722288618307 0.000113416001776986 NA NA NA hsa-miR-374a-3p WNT7A -0.299190081500425 0.00682975596757891 2.17548841896822 1.27532651052268e-07 MirTarget -0.782011644121057 1.84931464169463e-06 NA NA NA hsa-miR-3913-5p WNT7A 0.48532077857571 0.00112373589405304 2.17548841896822 1.27532651052268e-07 mirMAP -0.520316506606756 1.91652734520631e-05 NA NA NA hsa-miR-497-5p WNT7A -0.966244470847844 5.26505649147857e-12 2.17548841896822 1.27532651052268e-07 MirTarget -0.720047679687649 1.07500330892353e-08 NA NA NA hsa-miR-10b-5p WNT7B -0.582989331935508 4.56688330655626e-06 1.7004681714238 2.27477787935058e-17 mirMAP -0.254700491744119 0.000304932969815983 NA NA NA hsa-miR-30a-5p WNT7B -1.79779915425811 1.93360169837799e-26 1.7004681714238 2.27477787935058e-17 miRNATAP -0.466902672834237 1.18370343078737e-21 NA NA NA hsa-miR-30b-3p WNT7B -0.338530747940815 0.0223424741180399 1.7004681714238 2.27477787935058e-17 MirTarget;mirMAP -0.283717947694266 2.99907138520331e-06 NA NA NA hsa-miR-30c-5p WNT7B 0.021222006155897 0.886366656528128 1.7004681714238 2.27477787935058e-17 miRNATAP -0.248026630736634 4.49363608133385e-05 NA NA NA hsa-miR-30d-5p WNT7B -0.38399848121878 0.000171129616944749 1.7004681714238 2.27477787935058e-17 miRNATAP -0.387355730204942 1.12731679219259e-05 NA NA NA hsa-miR-326 WNT7B -0.425943992128769 0.0415010315530797 1.7004681714238 2.27477787935058e-17 MirTarget;miRanda -0.119317715803056 0.00592370357797529 NA NA NA hsa-miR-335-5p WNT7B -1.17227779671552 1.49282618530733e-10 1.7004681714238 2.27477787935058e-17 miRNAWalker2_validate -0.141127235729782 0.00359476145185812 NA NA NA hsa-miR-34a-5p WNT7B -0.117372471043915 0.364001947180738 1.7004681714238 2.27477787935058e-17 mirMAP -0.269459787758944 0.000117815770614211 NA NA NA hsa-miR-491-5p WNT7B -0.541680329196715 0.00135829217561865 1.7004681714238 2.27477787935058e-17 mirMAP -0.348417330977353 2.25675990553943e-10 NA NA NA hsa-miR-625-5p WNT7B 0.346770617079364 0.02860843739549 1.7004681714238 2.27477787935058e-17 mirMAP -0.311725290258202 4.06166953104253e-08 NA NA NA hsa-miR-664a-5p WNT7B -0.871809752100072 1.86842520324979e-08 1.7004681714238 2.27477787935058e-17 MirTarget -0.253065515953095 1.05052879457149e-05 NA NA NA hsa-miR-15a-5p WNT9A 0.783550182002274 2.60699595655907e-11 0.0990422421950703 0.673719860085433 mirMAP -0.493676321995247 6.0001956226427e-09 NA NA NA hsa-miR-193a-3p WNT9A 0.22120710726779 0.111827069464729 0.0990422421950703 0.673719860085433 mirMAP -0.283682307500411 0.000116395150642507 NA NA NA hsa-miR-363-3p WNT9A -0.608157508016978 0.0186109501272176 0.0990422421950703 0.673719860085433 mirMAP -0.150225234310504 0.000136888013162778 NA NA NA hsa-miR-589-3p WNT9A 1.59559692667315 6.2886410639161e-15 0.0990422421950703 0.673719860085433 mirMAP -0.208956780331595 3.5202221831103e-05 NA NA NA hsa-miR-106a-5p WTIP 0.67978010057847 0.00221925869726092 0.0952907228370439 0.553670626142713 mirMAP -0.154789781217852 6.6226647678162e-07 NA NA NA hsa-miR-106b-5p WTIP 0.50378717276868 1.45412404526866e-05 0.0952907228370439 0.553670626142713 mirMAP -0.282628344362074 2.23565048233843e-06 NA NA NA hsa-miR-107 WTIP -0.0447040564279497 0.671618791096755 0.0952907228370439 0.553670626142713 mirMAP -0.175320606495662 0.00893558228625908 NA NA NA hsa-miR-1262 WTIP -0.573333840008993 0.000460467165110432 0.0952907228370439 0.553670626142713 mirMAP -0.115529720363495 0.00854867651173429 NA NA NA hsa-miR-141-3p WTIP 0.730011517758706 0.000120338355004032 0.0952907228370439 0.553670626142713 mirMAP -0.161796834495506 9.1366001375338e-06 NA NA NA hsa-miR-15b-5p WTIP 0.85315666454713 3.79816274836297e-12 0.0952907228370439 0.553670626142713 mirMAP -0.304968592998329 3.81123364201048e-08 NA NA NA hsa-miR-16-5p WTIP 0.521122945828175 1.40561786410572e-06 0.0952907228370439 0.553670626142713 mirMAP -0.250668184204902 0.000100362384625549 NA NA NA hsa-miR-183-5p WTIP 1.4313129319945 6.25230916431996e-14 0.0952907228370439 0.553670626142713 mirMAP -0.11577338836937 0.00119849908929405 NA NA NA hsa-miR-200a-3p WTIP 0.607140814457753 0.00289840524858752 0.0952907228370439 0.553670626142713 mirMAP -0.136274501654427 6.43613149813376e-05 NA NA NA hsa-miR-205-3p WTIP 1.2960640797621 5.80786479909147e-11 0.0952907228370439 0.553670626142713 mirMAP -0.143210305729871 3.39800651834907e-05 NA NA NA hsa-miR-20b-5p WTIP 0.345967670847176 0.232014828043601 0.0952907228370439 0.553670626142713 mirMAP -0.114405776776031 1.89027769193959e-06 NA NA NA hsa-miR-224-3p WTIP 0.502645536188015 0.0081142387260641 0.0952907228370439 0.553670626142713 mirMAP -0.136606000755863 0.000219956272589978 NA NA NA hsa-miR-25-3p WTIP 0.76549796417801 3.32282098247097e-11 0.0952907228370439 0.553670626142713 mirMAP -0.160666326682384 0.00727170972491426 NA NA NA hsa-miR-27a-3p WTIP 0.348456440505425 0.00126682892514312 0.0952907228370439 0.553670626142713 mirMAP -0.171172333736633 0.00850410073044044 NA NA NA hsa-miR-27b-3p WTIP -0.732682718863563 2.26896143573324e-09 0.0952907228370439 0.553670626142713 mirMAP -0.328640792463822 3.85886658677833e-09 NA NA NA hsa-miR-29c-3p WTIP -2.08166260448948 8.3238369390898e-24 0.0952907228370439 0.553670626142713 mirMAP -0.150972296972336 2.51496631743463e-06 NA NA NA hsa-miR-32-5p WTIP -0.317310201890053 0.0102525324475293 0.0952907228370439 0.553670626142713 mirMAP -0.203090760773205 0.00034024572210566 NA NA NA hsa-miR-324-3p WTIP 0.867391246413545 3.63808540490361e-10 0.0952907228370439 0.553670626142713 mirMAP -0.235753869824221 1.94586826424337e-06 NA NA NA hsa-miR-331-3p WTIP 0.906385914819361 4.27653809739414e-11 0.0952907228370439 0.553670626142713 mirMAP -0.220549467806319 9.66313530531067e-06 NA NA NA hsa-miR-33b-5p WTIP 0.681845193600723 0.00407790722487864 0.0952907228370439 0.553670626142713 mirMAP -0.173496371087033 6.71737835990959e-09 NA NA NA hsa-miR-3615 WTIP 0.761416334979744 9.83072409815373e-09 0.0952907228370439 0.553670626142713 mirMAP -0.140470991672049 0.00710671137761183 NA NA NA hsa-miR-363-3p WTIP -0.608157508016978 0.0186109501272176 0.0952907228370439 0.553670626142713 mirMAP -0.140963038769621 1.38103524438034e-07 NA NA NA hsa-miR-92b-3p WTIP 0.869628761112414 4.71129204795212e-09 0.0952907228370439 0.553670626142713 mirMAP -0.124149044724333 0.00769192317744678 NA NA NA hsa-miR-106b-5p WWC1 0.50378717276868 1.45412404526866e-05 -1.127808904 4.77753162776302e-18 mirMAP -0.264640538862585 1.16210060707828e-07 NA NA NA hsa-miR-130b-3p WWC1 1.44628430084411 9.13980959861273e-24 -1.127808904 4.77753162776302e-18 mirMAP -0.279387080885881 2.61683911816673e-13 NA NA NA hsa-miR-155-5p WWC1 0.533437622040649 0.00248671179205372 -1.127808904 4.77753162776302e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.125453829862481 0.000150299688237702 NA NA NA hsa-miR-15a-5p WWC1 0.783550182002274 2.60699595655907e-11 -1.127808904 4.77753162776302e-18 MirTarget;miRNATAP -0.224110134861601 4.64320779371502e-06 NA NA NA hsa-miR-15b-5p WWC1 0.85315666454713 3.79816274836297e-12 -1.127808904 4.77753162776302e-18 MirTarget;miRNATAP -0.261405400371334 1.82612176270304e-08 NA NA NA hsa-miR-16-5p WWC1 0.521122945828175 1.40561786410572e-06 -1.127808904 4.77753162776302e-18 MirTarget;miRNATAP -0.224299700689873 3.22769792656055e-05 NA NA NA hsa-miR-17-5p WWC1 1.41924888736771 2.75805544953758e-18 -1.127808904 4.77753162776302e-18 mirMAP -0.104093999348605 0.00282944389994826 NA NA NA hsa-miR-20a-5p WWC1 1.1531986665452 1.02385132917958e-11 -1.127808904 4.77753162776302e-18 mirMAP -0.105336744851395 0.00189884623765064 NA NA NA hsa-miR-28-5p WWC1 -0.026996999089909 0.733047113251652 -1.127808904 4.77753162776302e-18 mirMAP -0.321159503944593 1.93153602510087e-05 NA NA NA hsa-miR-3913-5p WWC1 0.48532077857571 0.00112373589405304 -1.127808904 4.77753162776302e-18 mirMAP -0.230643438839953 3.31521683062561e-09 NA NA NA hsa-miR-421 WWC1 0.945488088619653 2.35762398527362e-09 -1.127808904 4.77753162776302e-18 mirMAP -0.137754852760651 0.000163753782412275 NA NA NA hsa-miR-423-5p WWC1 0.60141781325829 1.62940950644999e-07 -1.127808904 4.77753162776302e-18 miRNATAP -0.235430353863458 3.11353733194858e-06 NA NA NA hsa-miR-450b-5p WWC1 1.25529820885833 1.18847120528666e-15 -1.127808904 4.77753162776302e-18 mirMAP -0.155276181267847 1.82706800522605e-05 NA NA NA hsa-miR-454-3p WWC1 1.54137391927201 4.15861570449376e-20 -1.127808904 4.77753162776302e-18 mirMAP -0.154000118313965 4.20242288752964e-06 NA NA NA hsa-miR-92a-3p WWC1 0.994679542307232 1.32587679156217e-16 -1.127808904 4.77753162776302e-18 miRNATAP -0.209238841578101 9.65991237684909e-06 NA NA NA hsa-miR-92b-3p WWC1 0.869628761112414 4.71129204795212e-09 -1.127808904 4.77753162776302e-18 miRNATAP -0.113725572098178 0.00355870875760744 NA NA NA hsa-miR-93-5p WWC1 1.61042951896619 5.1280369606967e-24 -1.127808904 4.77753162776302e-18 mirMAP -0.212384430194922 9.45562850937903e-10 NA NA NA hsa-miR-130b-5p WWTR1 1.77265255049999 1.43627774829684e-29 -0.274990048461166 0.0613972004668567 MirTarget;miRNATAP -0.190476416971289 6.33622269021245e-07 NA NA NA hsa-miR-141-3p WWTR1 0.730011517758706 0.000120338355004032 -0.274990048461166 0.0613972004668567 MirTarget;TargetScan;miRNATAP -0.225893819087245 6.9256708263245e-12 NA NA NA hsa-miR-149-5p WWTR1 0.443278770827687 0.0642022866136881 -0.274990048461166 0.0613972004668567 miRNATAP -0.117409425462719 9.800112403443e-06 NA NA NA hsa-miR-155-5p WWTR1 0.533437622040649 0.00248671179205372 -0.274990048461166 0.0613972004668567 mirMAP -0.160385032075728 8.53269337857818e-06 NA NA NA hsa-miR-17-3p WWTR1 -0.0127974722290336 0.909559935689875 -0.274990048461166 0.0613972004668567 MirTarget -0.148126517107576 0.00979625915891333 NA NA NA hsa-miR-18a-5p WWTR1 1.65455873230328 3.76457892277775e-20 -0.274990048461166 0.0613972004668567 miRNAWalker2_validate -0.227561818643277 1.36837591198926e-11 NA NA NA hsa-miR-193a-3p WWTR1 0.22120710726779 0.111827069464729 -0.274990048461166 0.0613972004668567 miRanda -0.197889324829882 1.6642781046922e-05 NA NA NA hsa-miR-1976 WWTR1 0.638808083289405 2.94840228896364e-07 -0.274990048461166 0.0613972004668567 MirTarget -0.248472226712317 9.46814105445921e-07 NA NA NA hsa-miR-200a-3p WWTR1 0.607140814457753 0.00289840524858752 -0.274990048461166 0.0613972004668567 MirTarget;miRNATAP -0.249014856675143 2.92551849008361e-16 NA NA NA hsa-miR-205-5p WWTR1 1.50759485376634 2.0003886738248e-16 -0.274990048461166 0.0613972004668567 miRNATAP -0.219872595898169 4.15724478139091e-11 NA NA NA hsa-miR-29a-5p WWTR1 0.323252792625584 0.0370417231222825 -0.274990048461166 0.0613972004668567 mirMAP -0.262837383995141 1.0701250480804e-10 NA NA NA hsa-miR-29b-3p WWTR1 -0.110721443686039 0.511264554091106 -0.274990048461166 0.0613972004668567 miRNATAP -0.315973493872061 1.15333649575097e-17 NA NA NA hsa-miR-30a-5p WWTR1 -1.79779915425811 1.93360169837799e-26 -0.274990048461166 0.0613972004668567 MirTarget -0.100180713092877 0.00543514830586714 NA NA NA hsa-miR-30b-5p WWTR1 -0.400238605368173 0.00346540992719245 -0.274990048461166 0.0613972004668567 MirTarget;mirMAP -0.367987010230575 6.59492506117653e-16 NA NA NA hsa-miR-30c-5p WWTR1 0.021222006155897 0.886366656528128 -0.274990048461166 0.0613972004668567 MirTarget;mirMAP -0.405985803244308 1.45969326352961e-22 NA NA NA hsa-miR-30d-5p WWTR1 -0.38399848121878 0.000171129616944749 -0.274990048461166 0.0613972004668567 MirTarget;mirMAP -0.177621686211568 0.00474642383725059 NA NA NA hsa-miR-30e-5p WWTR1 -1.02114836019762 6.81961221797866e-17 -0.274990048461166 0.0613972004668567 MirTarget -0.284110345607161 1.75099429255497e-08 NA NA NA hsa-miR-320a WWTR1 0.801356001806321 4.91397101474502e-09 -0.274990048461166 0.0613972004668567 miRanda;miRNATAP -0.294166587812144 9.92305907340863e-11 NA NA NA hsa-miR-320b WWTR1 1.23473838180754 3.04337566045537e-14 -0.274990048461166 0.0613972004668567 miRanda;miRNATAP -0.16935491423747 9.44723534324068e-06 NA NA NA hsa-miR-3607-3p WWTR1 1.01377165357363 9.13355519701165e-05 -0.274990048461166 0.0613972004668567 mirMAP -0.165147194143618 7.39147300844843e-12 NA NA NA hsa-miR-374b-5p WWTR1 -0.288413933608091 0.0041474558664058 -0.274990048461166 0.0613972004668567 MirTarget;mirMAP -0.327631306421242 2.50182408613972e-07 NA NA NA hsa-miR-501-5p WWTR1 1.02806906860218 1.63456814370548e-09 -0.274990048461166 0.0613972004668567 mirMAP -0.233607774920109 2.57994497035101e-10 NA NA NA hsa-miR-576-5p WWTR1 0.940432050128373 6.90227595663302e-12 -0.274990048461166 0.0613972004668567 MirTarget;mirMAP -0.304550238535079 1.42786692355048e-11 NA NA NA hsa-miR-582-3p WWTR1 -0.248056267546012 0.143798829508405 -0.274990048461166 0.0613972004668567 miRNATAP -0.150039344100375 6.74936984803476e-05 NA NA NA hsa-miR-582-5p WWTR1 -0.0366995972742474 0.821827119138923 -0.274990048461166 0.0613972004668567 MirTarget;PITA -0.216546768876009 2.77197659135274e-08 NA NA NA hsa-miR-590-3p WWTR1 0.221436901462551 0.0965904764063157 -0.274990048461166 0.0613972004668567 MirTarget;miRanda;mirMAP -0.156390685442419 0.00117212648876997 NA NA NA hsa-miR-627-5p WWTR1 0.352962182324836 0.0471199545348354 -0.274990048461166 0.0613972004668567 MirTarget -0.114572616656327 0.00207290810134008 NA NA NA hsa-miR-651-5p WWTR1 0.504713329111777 0.00155970216047171 -0.274990048461166 0.0613972004668567 MirTarget -0.178341581765424 7.75601354056233e-06 NA NA NA hsa-miR-664a-3p WWTR1 -0.256108763664991 0.0513188660751664 -0.274990048461166 0.0613972004668567 MirTarget;mirMAP -0.270206650347103 2.32109610687192e-08 NA NA NA hsa-miR-7-1-3p WWTR1 1.13646121619622 1.49823237535933e-14 -0.274990048461166 0.0613972004668567 mirMAP -0.181949051922131 1.52632941493268e-05 NA NA NA hsa-miR-93-3p WWTR1 1.69225547123293 1.50964095575087e-25 -0.274990048461166 0.0613972004668567 MirTarget -0.273792955576156 1.05698961170927e-13 NA NA NA hsa-miR-141-3p YAP1 0.730011517758706 0.000120338355004032 -0.448449400215207 0.00483064916272573 MirTarget;TargetScan -0.12524007146805 0.000567114698846405 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-142-5p YAP1 0.288897753038094 0.0900009317815725 -0.448449400215207 0.00483064916272573 mirMAP -0.13997890045493 0.000591618003889418 NA NA NA hsa-miR-146b-5p YAP1 0.917975986853978 3.33749259316025e-09 -0.448449400215207 0.00483064916272573 miRanda -0.155945988294642 0.000403239925112207 NA NA NA hsa-miR-16-2-3p YAP1 1.1567130855258 1.01867256952189e-14 -0.448449400215207 0.00483064916272573 mirMAP -0.270290760242656 1.51905474941678e-09 NA NA NA hsa-miR-186-5p YAP1 0.353452958261612 0.000145058448579496 -0.448449400215207 0.00483064916272573 MirTarget -0.269061979465641 0.000331761459378352 27073580 We observed that miR-186 was downregulated in several HCC cell lines and that it directly targets YAP1 mRNA; Overexpression of miR-186 in HCC cells significantly downregulates YAP1 mRNA and protein levels leading to downregulation of the Hippo signaling pathway which in turn severely inhibits HCC cell migration invasion and proliferation; Our study is the first to report the direct involvement of miR-186 in downregulating YAP1 and more significantly inhibiting HCC tumorigenesis and supports the role miR-186 as a potential therapeutic target in treating liver cancer cell migration;tumorigenesis liver cancer hsa-miR-200a-3p YAP1 0.607140814457753 0.00289840524858752 -0.448449400215207 0.00483064916272573 miRNAWalker2_validate;MirTarget -0.128064291829832 0.000156631317777536 23340296 MicroRNA 200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer; We identified Yes-associated protein 1 YAP1 as a novel target of miR-200a; Our data showed that targeting of YAP1 by miR-200a resulted in decreased expression of proapoptotic proteins which leads to anoikis resistance; Remarkably we found that YAP1 expression was inversely correlated with miR-200a expression in breast cancer clinical specimens and miR-200a expression was associated with distant metastasis in patients with breast cancer metastasis;drug resistance breast cancer hsa-miR-200b-3p YAP1 0.0717138787925347 0.682858087587209 -0.448449400215207 0.00483064916272573 MirTarget -0.121781108960566 0.00212616391679142 NA NA NA hsa-miR-21-5p YAP1 1.62465922021121 3.44191300985109e-58 -0.448449400215207 0.00483064916272573 MirTarget;miRNATAP -0.203945163383554 0.000922233201659853 NA NA NA hsa-miR-3607-3p YAP1 1.01377165357363 9.13355519701165e-05 -0.448449400215207 0.00483064916272573 mirMAP -0.133075131894339 4.76743723799831e-07 NA NA NA hsa-miR-361-3p YAP1 0.272298288982435 0.0147874880476998 -0.448449400215207 0.00483064916272573 MirTarget;PITA -0.344346481188928 2.60185721046415e-08 NA NA NA hsa-miR-429 YAP1 0.559451508722375 0.00563641638673083 -0.448449400215207 0.00483064916272573 MirTarget;miRanda -0.111094579198098 0.00118173120800178 NA NA NA hsa-miR-532-5p YAP1 -0.021857649390892 0.830992272120134 -0.448449400215207 0.00483064916272573 PITA -0.258573696263795 0.000154806326936378 NA NA NA hsa-miR-590-3p YAP1 0.221436901462551 0.0965904764063157 -0.448449400215207 0.00483064916272573 miRanda;mirMAP -0.170516590575783 0.00110765670262921 NA NA NA hsa-miR-590-5p YAP1 0.763025362395968 3.65305892505623e-09 -0.448449400215207 0.00483064916272573 MirTarget;PITA;miRanda;miRNATAP -0.164768702402436 0.00191378909561026 NA NA NA hsa-miR-625-5p YAP1 0.346770617079364 0.02860843739549 -0.448449400215207 0.00483064916272573 MirTarget -0.220113724657545 5.05560886137403e-07 NA NA NA hsa-miR-7-1-3p YAP1 1.13646121619622 1.49823237535933e-14 -0.448449400215207 0.00483064916272573 mirMAP -0.143313068373772 0.00177048793724078 NA NA NA hsa-miR-9-5p YAP1 1.65694862043766 2.08325802567323e-05 -0.448449400215207 0.00483064916272573 miRNATAP -0.121789698045801 2.09771808640533e-12 NA NA NA hsa-miR-181c-5p YWHAB -0.168991199007857 0.196949106150297 0.00881901233011639 0.898873897369249 mirMAP -0.162599760897484 5.80022917244678e-13 NA NA NA hsa-miR-218-5p YWHAB -1.0725338636959 3.61493686604269e-09 0.00881901233011639 0.898873897369249 MirTarget;miRNATAP -0.129695867674064 2.61732110074287e-16 NA NA NA hsa-miR-28-3p YWHAB 0.459875450032895 3.47095927872566e-07 0.00881901233011639 0.898873897369249 mirMAP -0.121898698299706 0.000245458193878681 NA NA NA hsa-miR-26a-5p YWHAE -1.09269574587169 1.24020612216319e-22 -0.011693142597748 0.858085854108992 miRNAWalker2_validate;miRNATAP -0.134851355513539 2.34107313476958e-08 NA NA NA hsa-miR-30e-3p YWHAE -0.890635378639789 1.65740480611339e-16 -0.011693142597748 0.858085854108992 miRNAWalker2_validate;MirTarget -0.122782409777311 1.32307601654417e-06 NA NA NA hsa-miR-140-3p YWHAG -0.967453553824782 7.6999446305445e-23 0.330299865053775 0.000136511662733804 MirTarget;PITA;miRNATAP -0.103358457091299 0.00540157523681645 NA NA NA hsa-miR-148a-3p YWHAG -0.428944290834563 0.00954246923521465 0.330299865053775 0.000136511662733804 mirMAP -0.172562576929802 9.80841062387561e-15 NA NA NA hsa-miR-148b-3p YWHAG 0.386859166050437 4.6728211830726e-06 0.330299865053775 0.000136511662733804 mirMAP -0.127068459520355 0.00478750444470103 NA NA NA hsa-miR-181c-5p YWHAG -0.168991199007857 0.196949106150297 0.330299865053775 0.000136511662733804 MirTarget;miRNATAP -0.179801848435716 3.17700531037192e-10 NA NA NA hsa-miR-186-5p YWHAG 0.353452958261612 0.000145058448579496 0.330299865053775 0.000136511662733804 mirMAP -0.148835514391217 0.000264572338061396 NA NA NA hsa-miR-200a-3p YWHAG 0.607140814457753 0.00289840524858752 0.330299865053775 0.000136511662733804 MirTarget;miRNATAP -0.109714904319702 1.84079025598854e-09 NA NA NA hsa-miR-200b-3p YWHAG 0.0717138787925347 0.682858087587209 0.330299865053775 0.000136511662733804 MirTarget;TargetScan -0.119044631431967 2.4988893127847e-08 NA NA NA hsa-miR-30a-5p YWHAG -1.79779915425811 1.93360169837799e-26 0.330299865053775 0.000136511662733804 miRNATAP -0.146711637270905 2.05639265713117e-12 NA NA NA hsa-miR-30b-5p YWHAG -0.400238605368173 0.00346540992719245 0.330299865053775 0.000136511662733804 miRNATAP -0.157165643805315 8.77435645310602e-09 NA NA NA hsa-miR-30c-5p YWHAG 0.021222006155897 0.886366656528128 0.330299865053775 0.000136511662733804 miRNATAP -0.175640843750997 2.47764574936125e-12 NA NA NA hsa-miR-30d-5p YWHAG -0.38399848121878 0.000171129616944749 0.330299865053775 0.000136511662733804 miRNATAP -0.150426546243279 4.79824419705503e-05 NA NA NA hsa-miR-30e-5p YWHAG -1.02114836019762 6.81961221797866e-17 0.330299865053775 0.000136511662733804 miRNATAP -0.238931774160398 3.47283564025138e-16 NA NA NA hsa-miR-320a YWHAG 0.801356001806321 4.91397101474502e-09 0.330299865053775 0.000136511662733804 PITA;miRanda;miRNATAP -0.109092478160448 6.02904259165254e-05 NA NA NA hsa-miR-342-3p YWHAG 0.99756868977753 9.28499866272332e-10 0.330299865053775 0.000136511662733804 miRanda -0.129680704448062 9.51810845665504e-09 NA NA NA hsa-miR-361-3p YWHAG 0.272298288982435 0.0147874880476998 0.330299865053775 0.000136511662733804 miRNATAP -0.215264671621153 1.33485624045165e-10 NA NA NA hsa-miR-625-3p YWHAG 0.0858338965684338 0.484971431380441 0.330299865053775 0.000136511662733804 MirTarget -0.17427169354784 1.24901421052461e-08 NA NA NA hsa-miR-361-5p YWHAH 0.0803683277369505 0.314043140368058 0.606590747915194 2.2258270392452e-20 miRanda -0.143754438817592 0.000129662085983515 NA NA NA hsa-miR-140-5p YWHAQ -0.412389003031485 0.000136051708543369 0.297188016762384 0.000301717728960227 miRanda -0.144369110796683 1.28394289726585e-05 NA NA NA hsa-miR-320a YWHAQ 0.801356001806321 4.91397101474502e-09 0.297188016762384 0.000301717728960227 MirTarget;PITA;miRanda;miRNATAP -0.122791197390879 1.79476954628365e-06 NA NA NA hsa-miR-328-3p YWHAQ 0.153404163477345 0.292356842798574 0.297188016762384 0.000301717728960227 miRNAWalker2_validate -0.14067106382548 8.41883816895344e-09 NA NA NA hsa-miR-497-5p YWHAQ -0.966244470847844 5.26505649147857e-12 0.297188016762384 0.000301717728960227 MirTarget;miRNATAP -0.160727522583736 8.39459490325181e-11 NA NA NA hsa-miR-125a-5p YWHAZ 0.215366061934933 0.119550904549401 0.344806894705046 0.00159832448868044 miRanda -0.131737820968702 0.000133229843462919 NA NA NA hsa-miR-140-3p YWHAZ -0.967453553824782 7.6999446305445e-23 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRNATAP -0.332612441544844 4.02857377845901e-13 NA NA NA hsa-miR-195-3p YWHAZ -0.624259620429699 0.000164279659144497 0.344806894705046 0.00159832448868044 MirTarget -0.179161299851689 2.75832505706067e-10 NA NA NA hsa-miR-217 YWHAZ -1.35391381055929 2.42394951427902e-09 0.344806894705046 0.00159832448868044 miRanda -0.115379904046822 1.65379610658317e-08 NA NA NA hsa-miR-28-5p YWHAZ -0.026996999089909 0.733047113251652 0.344806894705046 0.00159832448868044 PITA;miRanda;miRNATAP -0.460593947828525 1.51249556078375e-14 NA NA NA hsa-miR-30a-5p YWHAZ -1.79779915425811 1.93360169837799e-26 0.344806894705046 0.00159832448868044 miRNAWalker2_validate;MirTarget;miRNATAP -0.257456100150205 1.20682025865332e-23 NA NA NA hsa-miR-30b-5p YWHAZ -0.400238605368173 0.00346540992719245 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.134959972136251 0.000102257748497268 NA NA NA hsa-miR-30c-5p YWHAZ 0.021222006155897 0.886366656528128 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.158375500764273 7.34079247818284e-07 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30d-5p YWHAZ -0.38399848121878 0.000171129616944749 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.182363700762594 9.34714131398731e-05 NA NA NA hsa-miR-30e-5p YWHAZ -1.02114836019762 6.81961221797866e-17 0.344806894705046 0.00159832448868044 MirTarget;miRNATAP -0.287219608655415 8.9471584773708e-15 NA NA NA hsa-miR-320a YWHAZ 0.801356001806321 4.91397101474502e-09 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRanda;miRNATAP -0.174562705304479 3.1139990151526e-07 NA NA NA hsa-miR-320b YWHAZ 1.23473838180754 3.04337566045537e-14 0.344806894705046 0.00159832448868044 MirTarget;PITA;miRanda;miRNATAP -0.1345921734285 2.20431003170386e-06 NA NA NA hsa-miR-328-3p YWHAZ 0.153404163477345 0.292356842798574 0.344806894705046 0.00159832448868044 MirTarget -0.158722107237606 1.12570217375833e-06 NA NA NA hsa-miR-335-3p YWHAZ 0.336785882180547 0.0542446207938138 0.344806894705046 0.00159832448868044 mirMAP -0.137412436277824 3.72360558086778e-07 NA NA NA hsa-miR-340-3p YWHAZ 0.289340144425255 0.0371281333347226 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.13819894036917 5.61930086606928e-05 NA NA NA hsa-miR-374a-3p YWHAZ -0.299190081500425 0.00682975596757891 0.344806894705046 0.00159832448868044 mirMAP -0.235356330221876 4.04380116686581e-08 NA NA NA hsa-miR-378a-3p YWHAZ -1.50453783521372 9.41694954361173e-17 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.138587190642273 4.20943927356468e-08 NA NA NA hsa-miR-3913-5p YWHAZ 0.48532077857571 0.00112373589405304 0.344806894705046 0.00159832448868044 MirTarget -0.119371212598511 0.000192155941997275 NA NA NA hsa-miR-423-5p YWHAZ 0.60141781325829 1.62940950644999e-07 0.344806894705046 0.00159832448868044 miRNAWalker2_validate -0.144999889763823 0.000434990684154854 NA NA NA hsa-miR-582-3p YWHAZ -0.248056267546012 0.143798829508405 0.344806894705046 0.00159832448868044 miRNATAP -0.14176604788771 3.76616387478394e-07 NA NA NA hsa-miR-582-5p YWHAZ -0.0366995972742474 0.821827119138923 0.344806894705046 0.00159832448868044 PITA -0.134128132346311 4.23230737234185e-06 NA NA NA hsa-miR-664a-3p YWHAZ -0.256108763664991 0.0513188660751664 0.344806894705046 0.00159832448868044 mirMAP -0.166079540885946 4.4590256821311e-06 NA NA NA