miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-let-7a-5p	AIFM1	-0.210286642041636	0.0072546234707717	0.674161514281666	1.79345695695194e-25	TargetScan;miRNATAP	-0.196627166194514	1.22215321527312e-11		NA	NA	NA
hsa-let-7b-5p	AIFM1	-0.54215483448257	7.21347617597858e-08	0.674161514281666	1.79345695695194e-25	miRNATAP	-0.196110440452601	7.42233386438707e-19		NA	NA	NA
hsa-let-7i-5p	AIFM1	-0.333419326258177	3.56960810786801e-08	0.674161514281666	1.79345695695194e-25	miRNATAP	-0.263687322690925	2.18002823821379e-12		NA	NA	NA
hsa-miR-125b-5p	AIFM1	-1.94393269763542	2.78180543229264e-58	0.674161514281666	1.79345695695194e-25	miRNATAP	-0.202683534719948	3.65034871714343e-33		NA	NA	NA
hsa-miR-145-5p	AIFM1	-2.62703571936687	7.64402900188551e-88	0.674161514281666	1.79345695695194e-25	miRNATAP	-0.134460530608588	6.48751185465965e-19	20332243	Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death		prostate cancer
hsa-miR-199a-5p	AIFM1	-0.314703593105081	0.00909304983051124	0.674161514281666	1.79345695695194e-25	miRanda	-0.139410895318402	7.90792762480272e-14		NA	NA	NA
hsa-miR-125b-5p	AKT1	-1.94393269763542	2.78180543229264e-58	0.675644771423915	4.31393881321574e-23	miRNAWalker2_validate;miRTarBase	-0.198341990959858	1.58124486218174e-28		NA	NA	NA
hsa-miR-143-3p	AKT1	-1.23248181631499	4.74160976678504e-28	0.675644771423915	4.31393881321574e-23	miRNAWalker2_validate	-0.113351907486334	3.74647210660112e-08		NA	NA	NA
hsa-miR-24-3p	AKT2	-0.120123317289941	0.21432376743243	-0.0243409112523851	0.696831042278932	mirMAP	-0.108581040434418	8.76204903485834e-07		NA	NA	NA
hsa-miR-30e-3p	AKT2	-0.708952170420973	1.05866470714978e-22	-0.0243409112523851	0.696831042278932	mirMAP	-0.10769217628588	0.000202699653075448		NA	NA	NA
hsa-miR-106b-5p	AKT3	1.22477789913175	2.31787213143326e-32	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.328917679851073	3.2761525214021e-13		NA	NA	NA
hsa-miR-107	AKT3	0.678998026350662	2.56224148930538e-16	-1.39153139819913	1.56022353185962e-23	PITA;miRanda	-0.322045444014362	3.05085750718847e-08		NA	NA	NA
hsa-miR-15a-5p	AKT3	0.812445324157528	4.50263417099822e-20	-1.39153139819913	1.56022353185962e-23	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.50537113863267	1.94212195956378e-21		NA	NA	NA
hsa-miR-15b-5p	AKT3	0.788659356634696	1.13678211092534e-11	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.193152993862959	3.52162993117826e-06		NA	NA	NA
hsa-miR-16-5p	AKT3	0.46835991343556	1.91125356547776e-06	-1.39153139819913	1.56022353185962e-23	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.137142128931012	0.00593844300257035		NA	NA	NA
hsa-miR-181a-5p	AKT3	0.635863607630183	6.72486918157744e-11	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.151700435123375	0.00241569058552761		NA	NA	NA
hsa-miR-181b-5p	AKT3	1.22749257795094	1.21998198830919e-27	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.228362092376509	5.2632904676588e-08		NA	NA	NA
hsa-miR-20a-5p	AKT3	0.44979911120222	0.000602386964327228	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.142287905559561	0.000137185408492637		NA	NA	NA
hsa-miR-29b-2-5p	AKT3	-0.263499971180298	0.0400001755611965	-1.39153139819913	1.56022353185962e-23	mirMAP	-0.174192327083419	4.9828909918003e-06		NA	NA	NA
hsa-miR-29b-3p	AKT3	0.438847962603729	6.46722433236121e-05	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.240095261108435	6.25012390753699e-08	26512921	MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3		ovarian cancer
hsa-miR-29c-3p	AKT3	-0.0652732378039769	0.563774115756922	-1.39153139819913	1.56022353185962e-23	miRNAWalker2_validate;miRNATAP	-0.188130633733952	1.47230271027192e-05		NA	NA	NA
hsa-miR-340-5p	AKT3	1.0857159627596	4.94471062546756e-24	-1.39153139819913	1.56022353185962e-23	mirMAP	-0.283834227072162	1.26866636163553e-10		NA	NA	NA
hsa-miR-769-5p	AKT3	0.564871766265874	8.16695101656941e-10	-1.39153139819913	1.56022353185962e-23	PITA;miRNATAP	-0.188201328225218	0.000387633821142586		NA	NA	NA
hsa-miR-93-5p	AKT3	1.01788600209314	1.24312921618126e-21	-1.39153139819913	1.56022353185962e-23	miRNATAP	-0.358774978428685	5.45504344144073e-16		NA	NA	NA
hsa-miR-27a-3p	APAF1	0.388496361379095	1.42373532086331e-05	-0.124144138683158	0.0608129314395015	miRNATAP	-0.119009261831353	2.41438306531375e-06		NA	NA	NA
hsa-miR-181a-5p	ATM	0.635863607630183	6.72486918157744e-11	-0.753520785022149	8.14866377341274e-18	miRNAWalker2_validate;miRTarBase;MirTarget	-0.212080382902989	6.50305312230929e-12	21102523;23656790;24531888;27150990;26113450	Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels;Ataxia-telangiectasia mutation ATM was predicted as a target gene of miR-181a with bioinformatics analysis and was verified by lucifersae reporter assay; A luciferase reporter assay demonstrated that ATM was a direct target of miR-181a miR-181a mimics transfection down regulated ATM mRNA and protein expression; There was inverse correlation between miR-181a and ATM protein expression in gastric cancer and normal gastric tissues; Our study demonstrates that over-expression of miR-181a might be involved in development of gastric cancer by promoting proliferation and inhibiting apoptosis probably through directly targeting ATM miR-181a modulation may be a potential strategy for the development of miRNA-based therapy of gastric cancer;MiR 181a Promotes Proliferation of Human Acute Myeloid Leukemia Cells by Targeting ATM; Dual luciferase reporter gene assay showed that miR-181a significantly suppressed the reporter gene activity containing ATM 3'-UTR by about 56.8% P < 0.05 but it didn't suppress the reporter gene activity containing 3'-UTR ATM mutation; Western blot showed that miR-181a significantly downregulated the expression of ATM in human leukemia cells; It is also found that miR-181a was significantly increased in AML which showed a negative correlation with ATM expression; miR-181a promotes cell proliferation in AML by regulating the tumor suppressor ATM thus it plays the role as oncogene in pathogenesis of AML;miR 181a promotes G1/S transition and cell proliferation in pediatric acute myeloid leukemia by targeting ATM; Pediatric AML patients and healthy controls were enrolled and the expression of miR-181a and ataxia telangiectasia mutated ATM in tissues were examined using quantitative PCR; Moreover cell proliferation and cell cycle were evaluated in several cell lines HL60 NB4 and K562 by using flow cytometry after transfected with miR-181a mimics and inhibitors or ATM siRNA and control siRNA; Finally ATM as the potential target protein of miR-181a was examined; We found that miR-181a was significantly increased in pediatric AML which showed an inverse association with ATM expression; Luciferase activity of the reporter construct identified ATM as the direct molecular target of miR-181a; The results revealed novel mechanism through which miR-181a regulates G1/S transition and cell proliferation in pediatric AML by regulating the tumor suppressor ATM providing insights into the molecular mechanism in pediatric AML	;;;;	breast cancer;breast cancer;gastric cancer;acute myeloid leukemia;acute myeloid leukemia
hsa-miR-181b-5p	ATM	1.22749257795094	1.21998198830919e-27	-0.753520785022149	8.14866377341274e-18	MirTarget	-0.217803705013907	3.99505534670018e-17	21102523;23656790	Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels	;	breast cancer;breast cancer
hsa-miR-181d-5p	ATM	0.782618466877349	1.2821116358212e-09	-0.753520785022149	8.14866377341274e-18	MirTarget	-0.119716083515509	3.28179905476897e-07		NA	NA	NA
hsa-miR-18a-5p	ATM	0.969066793715868	1.69069796425892e-08	-0.753520785022149	8.14866377341274e-18	miRNAWalker2_validate;miRTarBase;MirTarget	-0.116309277677122	3.16867464269194e-11	23857602;23437304;25963391;23229340	Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases	;;;progression	breast cancer;colorectal cancer;cervical and endocervical cancer;colon cancer
hsa-miR-21-5p	ATM	2.32007501846389	3.08394781855554e-137	-0.753520785022149	8.14866377341274e-18	mirMAP	-0.230974664847653	3.0596374789676e-17	26289851	MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy		thyroid cancer
hsa-miR-127-3p	BAD	-1.02337931491694	2.9749745518131e-15	0.671335929306102	6.05368129718844e-13	miRanda;miRNATAP	-0.12231920555334	5.77371456889348e-07		NA	NA	NA
hsa-miR-326	BAD	-1.54449030848141	1.04703417845594e-17	0.671335929306102	6.05368129718844e-13	miRanda	-0.162992963378128	2.73003852781454e-21		NA	NA	NA
hsa-miR-365a-3p	BAX	-1.45032725192851	2.37888098061118e-37	1.31138725140704	3.67717824400239e-48	miRNAWalker2_validate	-0.197311099125654	4.24250463560438e-13	24216611	MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX	drug resistance	pancreatic cancer
hsa-miR-130b-5p	BCL2	1.0573161199584	2.55177349228739e-12	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.298072526149562	1.58526199405774e-15	27364335	The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis		lung cancer
hsa-miR-136-5p	BCL2	0.0557692528524285	0.703264372780941	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.134479560632769	0.000722378019814531		NA	NA	NA
hsa-miR-142-3p	BCL2	1.53951237846104	2.06769936282034e-17	-0.895845361347303	1.04475176246219e-07	miRanda	-0.1459796770776	3.09176521823541e-06		NA	NA	NA
hsa-miR-148a-3p	BCL2	0.706969798912638	5.52538085480485e-09	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.220300574731754	3.43414567895446e-06	21455217;23975374	MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a	;	colorectal cancer;pancreatic cancer
hsa-miR-15a-5p	BCL2	0.812445324157528	4.50263417099822e-20	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.390139881240154	1.08000528360666e-09	25594541;22335947;26915294;18931683;25623762	MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells	;;poor survival;;drug resistance	breast cancer;breast cancer;lung cancer;prostate cancer;colon cancer
hsa-miR-15b-3p	BCL2	1.12898579025388	1.18050912917317e-14	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.310741788828047	6.78718604611496e-16	25594541;26915294;26884837;18449891	MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2	;poor survival;;drug resistance	breast cancer;lung cancer;liver cancer;gastric cancer
hsa-miR-15b-5p	BCL2	0.788659356634696	1.13678211092534e-11	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.282455107593279	9.40085716451768e-09	25594541;26915294;26884837;18449891	MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2	;poor survival;;drug resistance	breast cancer;lung cancer;liver cancer;gastric cancer
hsa-miR-16-1-3p	BCL2	1.30142784811196	2.53343713753744e-29	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.226601532507069	1.00488294259221e-05	18931683	MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2		prostate cancer
hsa-miR-16-2-3p	BCL2	0.286355254959005	0.0256946046884474	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.220617147018903	1.20839624748242e-06		NA	NA	NA
hsa-miR-17-5p	BCL2	0.599531757298529	1.07318660415906e-05	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.416922204785524	7.52642290968327e-24	25435430	Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2		lung cancer
hsa-miR-181a-5p	BCL2	0.635863607630183	6.72486918157744e-11	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.399174853804926	9.83051271483704e-12	24335172;24267199;23740615;25524579;27534652	The function role of miR 181a in chemosensitivity to adriamycin by targeting Bcl 2 in low invasive breast cancer cells; Luciferase reporter vector with the putative BCL-2 3' untranslated region 3'UTR was constructed to explore whether BCL-2 was a direct target gene of miR-181a; Real-time PCR was performed to test the expression of miR-181a and Bcl-2 in the selected breast cancer tissue samples; Transfected with miR-181a mimic in cells resulted in the decreased expression of Bcl-2; At least in part the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of miR-181a enhanced adriamycin-induced apoptosis via targeting Bcl-2;Bufalin was found to induce the expression of miR-181a a small non-coding RNA believed to induce apoptosis by repressing its target gene BCL-2; In prostate cancer PC-3cell line bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation;The results from Western blotting indicated that miR-181a might be associated with the up-regulation of bcl-2 and matrix metalloproteinase 9 and the down-regulation of tissue inhibitor of metalloproteinases-3 and p21 in MG63 cells;Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression;In addition inhibition of miR-181a promoted apoptosis of HeLa and CaSKi cells due to increasing Bax expression and decreasing Bcl-2 expression	;;;;	breast cancer;prostate cancer;sarcoma;lung squamous cell cancer;cervical and endocervical cancer
hsa-miR-181b-5p	BCL2	1.22749257795094	1.21998198830919e-27	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.46875883187563	8.08303248718094e-22	25524579	Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression		lung squamous cell cancer
hsa-miR-186-5p	BCL2	-0.426987301460247	1.04129380549315e-05	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.348265462226792	5.09173882444383e-09		NA	NA	NA
hsa-miR-192-5p	BCL2	1.33366224451777	9.5116159697107e-29	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate	-0.170899649695256	0.000266209546627792	26550150	MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192	drug resistance	lung cancer
hsa-miR-20a-3p	BCL2	-0.218902047543766	0.179868363625547	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.13906123260096	9.78039595655978e-05		NA	NA	NA
hsa-miR-20a-5p	BCL2	0.44979911120222	0.000602386964327228	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.398529315160521	3.65662136244948e-20		NA	NA	NA
hsa-miR-21-5p	BCL2	2.32007501846389	3.08394781855554e-137	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.486116466611641	4.94993012898121e-21	26555418;21468550;25994220;25381586;23359184;22964582;21376256	The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells	;;;;;;drug resistance	breast cancer;bladder cancer;colorectal cancer;sarcoma;pancreatic cancer;lung cancer;pancreatic cancer
hsa-miR-224-5p	BCL2	-2.22249420723892	1.07787949391113e-18	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.241222882395465	2.18051025428057e-28	24796455	In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01		gastric cancer
hsa-miR-24-2-5p	BCL2	-0.222445793556803	0.059573849265115	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.314657429269267	1.22690370959234e-10		NA	NA	NA
hsa-miR-29a-5p	BCL2	0.334183773952055	0.00445137265870197	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.158728142208395	0.00138976145130829	20041405	Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29		liver cancer
hsa-miR-33a-5p	BCL2	1.35185127289399	9.80509199125785e-12	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.201771252418707	4.45169669138265e-12		NA	NA	NA
hsa-miR-34a-5p	BCL2	0.129201805242403	0.133261654068224	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.21690891602483	0.00143015924808101	24565525;22623155;21399894;23155233;24444609;20687223;24988056;18803879;19714243;25053345;20433755;22964582;23862748	In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression	drug resistance;;;;poor survival;drug resistance;;poor survival;differentiation;poor survival;drug resistance;;;	breast cancer;breast cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;lung cancer;liver cancer
hsa-miR-374a-5p	BCL2	-0.239709888246804	0.00309819667153627	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.330216657607334	4.44639283995132e-06		NA	NA	NA
hsa-miR-374b-5p	BCL2	-0.466781429946153	1.17238311619116e-08	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.283877494124907	6.14149967949098e-05		NA	NA	NA
hsa-miR-409-3p	BCL2	-0.484157606580319	4.02222513573154e-05	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.140997687582626	0.00424621383085417		NA	NA	NA
hsa-miR-429	BCL2	2.84108892259147	3.88520896426515e-64	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase;PITA;mirMAP	-0.121974754205047	0.000143492269579093	23999873;26513239;26511969	MiR 429 up regulation induces apoptosis and suppresses invasion by targeting Bcl 2 and SP 1 in esophageal carcinoma; Subsequent Western blotting and luciferase reporter assays showed that miR-429 can bind to putative binding sites within the Bcl-2 and SP1 mRNA 3' untranslated regions UTRs to reduce their expression; Up-regulation of miR-429 inhibits invasion and promotes apoptosis in EC cells by targeting Bcl-2 and SP1; Our findings suggest that Bcl-2 and SP1 may serve as major targets of miR-429;MiR 429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl 2; Here we studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens; We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells; MiR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GC specimens compared to the paired adjacent non-tumor gastric tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated in GC specimens; Bioinformatics analyses showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation which was confirmed by luciferase-reporter assay;MiR 429 induces apoptosis of glioblastoma cell through Bcl 2; Here we analyzed the levels of miR-429 and anti-apoptotic protein Bcl-2 in GBM specimens; We combined bioinformatics analyses and luciferase reporter assay to determine the relationship between miR-429 and Bcl-2 in GBM cells; We found that miR-429 levels were significantly decreased and Bcl-2 levels were significantly increased in GBM specimens compared to the paired adjacent non-tumor brain tissue; Moreover the levels of miR-429 and Bcl-2 inversely correlated; MiR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its translation	;;	esophageal cancer;gastric cancer;glioblastoma
hsa-miR-450b-5p	BCL2	0.781564228875267	3.90462514315383e-11	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.230258059009763	2.05822889351104e-06		NA	NA	NA
hsa-miR-452-5p	BCL2	-2.48486455572568	1.24430987974325e-33	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.281160548783898	1.07099917549241e-26		NA	NA	NA
hsa-miR-455-5p	BCL2	0.284641224662773	0.0357572339594277	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.409582744430861	1.37477678088678e-22		NA	NA	NA
hsa-miR-542-3p	BCL2	0.568822103820889	8.5699075257651e-07	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.198415663601992	7.32195879993002e-05		NA	NA	NA
hsa-miR-582-5p	BCL2	0.201134299470983	0.149482495292227	-0.895845361347303	1.04475176246219e-07	PITA	-0.224134268204108	9.13307546512698e-08		NA	NA	NA
hsa-miR-590-3p	BCL2	1.27438512890514	1.03164723481469e-23	-0.895845361347303	1.04475176246219e-07	miRanda;mirMAP	-0.386064412166968	3.36735476522038e-17		NA	NA	NA
hsa-miR-590-5p	BCL2	0.746515607868274	8.51300479640125e-09	-0.895845361347303	1.04475176246219e-07	miRanda	-0.432407489499855	2.16078449133157e-23		NA	NA	NA
hsa-let-7c-5p	BCL2L1	-1.9415540533505	9.55250745007793e-48	0.522792065960586	7.61639356485872e-19	miRNAWalker2_validate;miRTarBase	-0.128294871675362	1.88688918547409e-19	20347499	Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA		liver cancer
hsa-let-7g-5p	BCL2L1	0.0200025784917734	0.791635298815256	0.522792065960586	7.61639356485872e-19	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.126630887025706	3.82717679314587e-06	20347499	Over-expression of let-7c or let-7g led to a clear decrease of Bcl-xL expression in Huh7 and HepG2 cell lines; Reporter assays revealed direct post-transcriptional regulation involving let-7c or let-7g and the 3'-untranslated region of bcl-xl mRNA		liver cancer
hsa-let-7i-5p	BCL2L1	-0.333419326258177	3.56960810786801e-08	0.522792065960586	7.61639356485872e-19	miRNATAP	-0.321772345664847	8.06744439816135e-22		NA	NA	NA
hsa-miR-140-5p	BCL2L1	-0.755971041589807	9.68060922934542e-14	0.522792065960586	7.61639356485872e-19	PITA;miRanda;miRNATAP	-0.178298678075701	1.10325405117987e-19		NA	NA	NA
hsa-miR-505-5p	BCL2L1	-0.842640534241897	4.43022473091907e-09	0.522792065960586	7.61639356485872e-19	miRNATAP	-0.108734867438394	1.06030624737444e-14		NA	NA	NA
hsa-miR-29c-3p	BIRC2	-0.0652732378039769	0.563774115756922	-0.297575740558402	4.48184300523481e-07	MirTarget	-0.121096414722903	1.04617957302389e-11		NA	NA	NA
hsa-miR-375	BIRC3	2.09893673049766	1.68351780396203e-16	-0.218777544640556	0.161832422376856	miRNAWalker2_validate	-0.126687363073563	5.66067780629141e-10	23726271	Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization		head and neck cancer
hsa-miR-664a-3p	BIRC3	-0.237699857923843	0.0197071390183375	-0.218777544640556	0.161832422376856	mirMAP	-0.161690203472487	0.00216600443131899		NA	NA	NA
hsa-miR-140-5p	CAPN1	-0.755971041589807	9.68060922934542e-14	0.603584891093352	6.70176366731414e-22	miRanda;miRNATAP	-0.124957501799464	4.3750761760043e-09		NA	NA	NA
hsa-miR-101-3p	CAPN2	-0.126035286271986	0.145997832808138	-0.0838811877894408	0.360020200535227	miRNAWalker2_validate;MirTarget	-0.149003956616061	4.12361423682102e-05		NA	NA	NA
hsa-miR-107	CAPN2	0.678998026350662	2.56224148930538e-16	-0.0838811877894408	0.360020200535227	miRanda	-0.176020877270818	2.30390840431672e-06		NA	NA	NA
hsa-miR-125a-5p	CASP10	-0.635694700253268	3.6703235721638e-11	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.177820442824944	1.14974523663095e-05		NA	NA	NA
hsa-miR-181a-5p	CASP10	0.635863607630183	6.72486918157744e-11	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.167506455297156	2.81512484479157e-05		NA	NA	NA
hsa-miR-181b-5p	CASP10	1.22749257795094	1.21998198830919e-27	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.167102695297352	7.08258362002032e-07		NA	NA	NA
hsa-miR-181c-5p	CASP10	0.574847839298605	4.51287502066478e-07	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.286608402089331	2.10718338906629e-17		NA	NA	NA
hsa-miR-19a-3p	CASP10	0.817507952171848	3.76285090469625e-08	-1.06975607492518	1.19238028683847e-21	MirTarget;mirMAP	-0.123492546324159	2.38250886062143e-06		NA	NA	NA
hsa-miR-19b-1-5p	CASP10	0.647704962003062	3.07687667945597e-07	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.145110342832673	2.51939892977316e-06		NA	NA	NA
hsa-miR-19b-3p	CASP10	0.139124391010031	0.255658553872934	-1.06975607492518	1.19238028683847e-21	MirTarget;mirMAP	-0.129061129824549	5.98267977322353e-05		NA	NA	NA
hsa-miR-200b-3p	CASP10	2.11744072703209	1.66710572104191e-43	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.239445518155442	5.07791301456485e-24		NA	NA	NA
hsa-miR-200c-3p	CASP10	2.07038651806183	6.84613386286599e-51	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.273509969637675	6.53447298083599e-26		NA	NA	NA
hsa-miR-21-5p	CASP10	2.32007501846389	3.08394781855554e-137	-1.06975607492518	1.19238028683847e-21	mirMAP	-0.182489722562965	2.9340743714182e-07		NA	NA	NA
hsa-miR-30b-3p	CASP10	-0.536462824497982	2.41814659272548e-05	-1.06975607492518	1.19238028683847e-21	MirTarget	-0.114632426890432	0.000219596665102797		NA	NA	NA
hsa-miR-338-3p	CASP10	0.0799903526884966	0.575137668326679	-1.06975607492518	1.19238028683847e-21	miRanda	-0.135288528791404	8.56458851996976e-07		NA	NA	NA
hsa-miR-429	CASP10	2.84108892259147	3.88520896426515e-64	-1.06975607492518	1.19238028683847e-21	mirMAP;miRNATAP	-0.212886532614725	8.1773549392356e-24		NA	NA	NA
hsa-let-7a-5p	CASP3	-0.210286642041636	0.0072546234707717	0.666045797044402	6.39452182888629e-31	miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP	-0.195644898270621	4.6747877969906e-14		NA	NA	NA
hsa-let-7b-5p	CASP3	-0.54215483448257	7.21347617597858e-08	0.666045797044402	6.39452182888629e-31	MirTarget;miRNATAP	-0.135377392684109	1.39837315047849e-11		NA	NA	NA
hsa-let-7c-5p	CASP3	-1.9415540533505	9.55250745007793e-48	0.666045797044402	6.39452182888629e-31	MirTarget	-0.131994349405243	7.44021418353714e-21		NA	NA	NA
hsa-miR-101-3p	CASP3	-0.126035286271986	0.145997832808138	0.666045797044402	6.39452182888629e-31	MirTarget	-0.205647208491522	1.01890278591706e-18		NA	NA	NA
hsa-miR-139-5p	CASP3	-3.25846663863766	2.62018989415003e-112	0.666045797044402	6.39452182888629e-31	miRanda	-0.133754697836399	1.82907069570434e-29		NA	NA	NA
hsa-miR-195-3p	CASP3	-1.49582726452416	6.53261924105147e-40	0.666045797044402	6.39452182888629e-31	MirTarget	-0.161373451028419	9.65654022351954e-22		NA	NA	NA
hsa-miR-30a-5p	CASP3	-0.392489994825279	0.00954894667761676	0.666045797044402	6.39452182888629e-31	miRNATAP	-0.146653827176832	2.4661703600601e-29		NA	NA	NA
hsa-miR-30c-5p	CASP3	-0.393222674580066	8.06961465717306e-05	0.666045797044402	6.39452182888629e-31	miRNATAP	-0.111784978428745	4.21945016044375e-08		NA	NA	NA
hsa-miR-106b-5p	CASP7	1.22477789913175	2.31787213143326e-32	0.0960684078333616	0.182578616272612	miRNAWalker2_validate	-0.110927422653021	1.26003328173106e-06	22986525	MicroRNA 106b 25 cluster expression is associated with early disease recurrence and targets caspase 7 and focal adhesion in human prostate cancer; Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3; The approach revealed that CASP7 is a direct target of miR-106b which was confirmed by western blot analysis and a 3'-untranslated region reporter assay; Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited	recurrence	prostate cancer
hsa-miR-132-3p	CASP7	-0.0365213889238607	0.668598301088667	0.0960684078333616	0.182578616272612	miRNAWalker2_validate;MirTarget	-0.107439780267955	0.000220260395052539		NA	NA	NA
hsa-miR-361-5p	CASP7	-0.0996867547900457	0.095428250126326	0.0960684078333616	0.182578616272612	PITA;miRanda	-0.188787955079821	6.30808566269869e-06		NA	NA	NA
hsa-miR-20a-5p	CASP8	0.44979911120222	0.000602386964327228	0.126270388614871	0.0614764679436649	MirTarget	-0.120887766356647	3.653106895295e-12		NA	NA	NA
hsa-miR-17-5p	CASP9	0.599531757298529	1.07318660415906e-05	0.0553003248250161	0.30285132191595	TargetScan	-0.101631873053047	1.40876150138688e-14		NA	NA	NA
hsa-miR-107	CFLAR	0.678998026350662	2.56224148930538e-16	-1.00505728235808	9.64786739519997e-33	miRanda	-0.135455220994877	0.000154859383776607		NA	NA	NA
hsa-miR-338-3p	CFLAR	0.0799903526884966	0.575137668326679	-1.00505728235808	9.64786739519997e-33	miRanda;mirMAP	-0.121412509761298	6.80132044970643e-09		NA	NA	NA
hsa-miR-15a-5p	CHUK	0.812445324157528	4.50263417099822e-20	-0.0655383466936339	0.252025603609673	miRNAWalker2_validate;miRTarBase;MirTarget	-0.135155500445723	3.1799004977298e-10		NA	NA	NA
hsa-miR-125a-5p	CSF2RB	-0.635694700253268	3.6703235721638e-11	-0.429244381931033	0.00155997953965177	miRanda	-0.342738630342494	5.64330349125e-13		NA	NA	NA
hsa-miR-181c-5p	CSF2RB	0.574847839298605	4.51287502066478e-07	-0.429244381931033	0.00155997953965177	MirTarget	-0.117493887020018	0.00393145815724916		NA	NA	NA
hsa-miR-181d-5p	CSF2RB	0.782618466877349	1.2821116358212e-09	-0.429244381931033	0.00155997953965177	MirTarget	-0.175286399953369	8.92491566553761e-07		NA	NA	NA
hsa-miR-30b-3p	CSF2RB	-0.536462824497982	2.41814659272548e-05	-0.429244381931033	0.00155997953965177	MirTarget	-0.171488311438998	2.87804505829104e-06		NA	NA	NA
hsa-miR-139-5p	CYCS	-3.25846663863766	2.62018989415003e-112	0.514544707933127	7.20434543139638e-13	miRanda	-0.138771276194956	1.91475094017139e-21		NA	NA	NA
hsa-miR-34c-5p	CYCS	-0.0896438810345765	0.557016551646841	0.514544707933127	7.20434543139638e-13	miRanda	-0.106641084379626	4.91599767479111e-11		NA	NA	NA
hsa-miR-495-3p	CYCS	-1.67685437612894	1.70634429769052e-34	0.514544707933127	7.20434543139638e-13	mirMAP	-0.103209359396361	2.73071281717473e-09		NA	NA	NA
hsa-miR-365a-3p	DFFB	-1.45032725192851	2.37888098061118e-37	0.188741064916102	0.0019728733557537	MirTarget	-0.123337323732796	1.3394208762177e-12		NA	NA	NA
hsa-miR-181a-5p	ENDOD1	0.635863607630183	6.72486918157744e-11	-0.662086054657753	1.91767717326514e-11	MirTarget	-0.189683107950902	4.37281846681927e-08		NA	NA	NA
hsa-miR-181b-5p	ENDOD1	1.22749257795094	1.21998198830919e-27	-0.662086054657753	1.91767717326514e-11	MirTarget	-0.180407157525064	6.27867737417705e-10		NA	NA	NA
hsa-miR-361-5p	ENDOD1	-0.0996867547900457	0.095428250126326	-0.662086054657753	1.91767717326514e-11	MirTarget;miRanda	-0.328469522766262	1.32367340539702e-08		NA	NA	NA
hsa-miR-589-5p	ENDOD1	0.367182541239722	1.67804815542873e-05	-0.662086054657753	1.91767717326514e-11	MirTarget	-0.177152650581664	9.75777718401495e-06		NA	NA	NA
hsa-let-7a-5p	FAS	-0.210286642041636	0.0072546234707717	-0.759637724162876	2.18688041634812e-12	TargetScan	-0.147010045095826	0.00234531576557678		NA	NA	NA
hsa-miR-338-3p	FAS	0.0799903526884966	0.575137668326679	-0.759637724162876	2.18688041634812e-12	miRanda	-0.16768795837118	1.3473835302647e-10		NA	NA	NA
hsa-miR-98-5p	FAS	0.656336869298973	9.03113188590466e-15	-0.759637724162876	2.18688041634812e-12	miRNAWalker2_validate	-0.147800482737569	0.000760862411963529		NA	NA	NA
hsa-let-7a-5p	FASLG	-0.210286642041636	0.0072546234707717	0.202786291597416	0.303256769370056	TargetScan;miRNATAP	-0.254557236142898	0.0033640838487851		NA	NA	NA
hsa-let-7b-5p	FASLG	-0.54215483448257	7.21347617597858e-08	0.202786291597416	0.303256769370056	miRNATAP	-0.244673453612857	0.000244706869361269		NA	NA	NA
hsa-let-7e-5p	FASLG	0.261471269338985	0.00191077095550257	0.202786291597416	0.303256769370056	miRNATAP	-0.337100053640702	2.69864596660333e-05		NA	NA	NA
hsa-miR-146b-5p	IKBKB	0.631041661167954	6.20366593452965e-08	0.273066826249678	0.00234033685126725	miRanda	-0.152908526927625	4.45729055656516e-09		NA	NA	NA
hsa-miR-151a-3p	IKBKB	0.3530403796941	3.45015092968892e-05	0.273066826249678	0.00234033685126725	miRNAWalker2_validate	-0.109349947297392	0.0025250144404732		NA	NA	NA
hsa-miR-28-5p	IKBKB	-0.14267073663385	0.0497619246260571	0.273066826249678	0.00234033685126725	miRanda	-0.249159305195741	4.36298401628208e-09		NA	NA	NA
hsa-miR-324-5p	IKBKB	0.211552647440779	0.139408130311654	0.273066826249678	0.00234033685126725	miRanda	-0.118429787871439	3.07201825932054e-08		NA	NA	NA
hsa-miR-330-5p	IKBKB	0.626063225953928	3.42215028606779e-09	0.273066826249678	0.00234033685126725	miRanda	-0.115452535316074	6.19261343388698e-05		NA	NA	NA
hsa-miR-590-3p	IKBKB	1.27438512890514	1.03164723481469e-23	0.273066826249678	0.00234033685126725	miRanda;mirMAP	-0.100127823485223	4.7662908944255e-05		NA	NA	NA
hsa-miR-125a-5p	IKBKG	-0.635694700253268	3.6703235721638e-11	0.490716396303581	1.1441359682473e-11	miRanda	-0.228007302003838	2.38576015741085e-19		NA	NA	NA
hsa-miR-140-5p	IKBKG	-0.755971041589807	9.68060922934542e-14	0.490716396303581	1.1441359682473e-11	miRanda	-0.125852887257061	2.14634764656029e-07		NA	NA	NA
hsa-miR-3607-3p	IKBKG	0.00697875745616461	0.972073275173643	0.490716396303581	1.1441359682473e-11	mirMAP	-0.123479124494569	5.75170407705992e-24		NA	NA	NA
hsa-miR-130b-5p	IL1R1	1.0573161199584	2.55177349228739e-12	-1.34299021321699	3.96277058038665e-24	mirMAP	-0.134792075843703	9.62989300771142e-06		NA	NA	NA
hsa-miR-17-3p	IL1R1	0.721439431208839	7.95900548819742e-10	-1.34299021321699	3.96277058038665e-24	mirMAP	-0.264058620225795	1.43612311566876e-11		NA	NA	NA
hsa-miR-192-5p	IL1R1	1.33366224451777	9.5116159697107e-29	-1.34299021321699	3.96277058038665e-24	miRNAWalker2_validate	-0.29199087319334	3.85990473776844e-15		NA	NA	NA
hsa-miR-30d-3p	IL1R1	0.264544633563642	0.00755023189129747	-1.34299021321699	3.96277058038665e-24	mirMAP	-0.226015646684785	1.68705773637213e-06		NA	NA	NA
hsa-miR-590-3p	IL1R1	1.27438512890514	1.03164723481469e-23	-1.34299021321699	3.96277058038665e-24	miRanda;miRNATAP	-0.200131921987377	7.85936325921516e-08		NA	NA	NA
hsa-miR-106b-5p	IL1RAP	1.22477789913175	2.31787213143326e-32	-0.759572369248282	5.03872337590099e-11	MirTarget	-0.21747394048456	4.55727177522678e-09		NA	NA	NA
hsa-miR-107	IL1RAP	0.678998026350662	2.56224148930538e-16	-0.759572369248282	5.03872337590099e-11	miRanda	-0.354516667427086	5.43471185449583e-14		NA	NA	NA
hsa-miR-16-1-3p	IL1RAP	1.30142784811196	2.53343713753744e-29	-0.759572369248282	5.03872337590099e-11	mirMAP	-0.1127844883818	0.00146965071147975		NA	NA	NA
hsa-miR-29b-3p	IL1RAP	0.438847962603729	6.46722433236121e-05	-0.759572369248282	5.03872337590099e-11	MirTarget;miRNATAP	-0.163903329531063	6.4615367353943e-06		NA	NA	NA
hsa-miR-29c-3p	IL1RAP	-0.0652732378039769	0.563774115756922	-0.759572369248282	5.03872337590099e-11	MirTarget;miRNATAP	-0.286804830052282	2.35500785921953e-16		NA	NA	NA
hsa-miR-375	IL1RAP	2.09893673049766	1.68351780396203e-16	-0.759572369248282	5.03872337590099e-11	miRNAWalker2_validate;miRanda	-0.111918762451102	1.90407427894537e-13		NA	NA	NA
hsa-miR-454-3p	IL1RAP	1.28177672191095	6.84024979484587e-21	-0.759572369248282	5.03872337590099e-11	MirTarget	-0.105478734601112	0.000246650313553492		NA	NA	NA
hsa-miR-93-5p	IL1RAP	1.01788600209314	1.24312921618126e-21	-0.759572369248282	5.03872337590099e-11	MirTarget	-0.2257972040621	5.94448947863886e-10		NA	NA	NA
hsa-miR-149-5p	IRAK1	0.218233101703391	0.261629158371175	0.814735838416841	1.12311003202643e-20	mirMAP	-0.101659491414051	7.46121484589551e-11		NA	NA	NA
hsa-miR-141-3p	IRAK3	2.99777540204168	1.26370498493024e-78	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.395371091533372	5.07583894364656e-39		NA	NA	NA
hsa-miR-16-1-3p	IRAK3	1.30142784811196	2.53343713753744e-29	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.317549883095679	9.31936816646031e-11		NA	NA	NA
hsa-miR-16-2-3p	IRAK3	0.286355254959005	0.0256946046884474	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.204410225746941	2.94894686008826e-06		NA	NA	NA
hsa-miR-16-5p	IRAK3	0.46835991343556	1.91125356547776e-06	-1.84214553446996	7.98016779710475e-32	miRNAWalker2_validate	-0.224494266578747	7.48648305027479e-05		NA	NA	NA
hsa-miR-200a-3p	IRAK3	2.55218480823434	2.96135446816238e-51	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.318261128528154	5.73130945956319e-26		NA	NA	NA
hsa-miR-21-5p	IRAK3	2.32007501846389	3.08394781855554e-137	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.432949994242884	3.91318586050703e-18		NA	NA	NA
hsa-miR-32-5p	IRAK3	1.38676603945192	2.29428299685976e-34	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.340329221828206	3.39112214525709e-13		NA	NA	NA
hsa-miR-320b	IRAK3	0.412787504747938	0.00113457276903985	-1.84214553446996	7.98016779710475e-32	miRanda	-0.170503311378059	0.000115799815404031		NA	NA	NA
hsa-miR-324-5p	IRAK3	0.211552647440779	0.139408130311654	-1.84214553446996	7.98016779710475e-32	miRanda	-0.179294712941118	4.21304683087341e-06		NA	NA	NA
hsa-miR-330-3p	IRAK3	0.432728362037032	0.00041335506960812	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.131278534076491	0.00452992739410884		NA	NA	NA
hsa-miR-330-5p	IRAK3	0.626063225953928	3.42215028606779e-09	-1.84214553446996	7.98016779710475e-32	miRanda	-0.20802901259839	7.14318546182645e-05		NA	NA	NA
hsa-miR-33a-5p	IRAK3	1.35185127289399	9.80509199125785e-12	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.156967006595365	2.52311898361291e-08		NA	NA	NA
hsa-miR-340-5p	IRAK3	1.0857159627596	4.94471062546756e-24	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.221921373949816	1.17405342424141e-05		NA	NA	NA
hsa-miR-429	IRAK3	2.84108892259147	3.88520896426515e-64	-1.84214553446996	7.98016779710475e-32	miRanda	-0.334670000939921	3.85801572773716e-29		NA	NA	NA
hsa-miR-590-3p	IRAK3	1.27438512890514	1.03164723481469e-23	-1.84214553446996	7.98016779710475e-32	miRanda;mirMAP	-0.296371249555745	2.39675147488628e-11		NA	NA	NA
hsa-miR-590-5p	IRAK3	0.746515607868274	8.51300479640125e-09	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.272908984767146	1.27456596403924e-10		NA	NA	NA
hsa-miR-660-5p	IRAK3	0.406910761707485	0.000156175371762464	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.190008554834879	0.000251329156707178		NA	NA	NA
hsa-miR-7-1-3p	IRAK3	0.686579567507582	1.20731554448806e-07	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.242971494797642	1.1381655944653e-08		NA	NA	NA
hsa-miR-92b-3p	IRAK3	1.30248132773644	9.42428674470985e-25	-1.84214553446996	7.98016779710475e-32	mirMAP	-0.192303735024889	6.79786003585688e-06		NA	NA	NA
hsa-miR-331-3p	MAP3K14	0.74441480542886	1.17071235477799e-07	-0.382347455234441	4.23425075991379e-06	MirTarget	-0.148338380185048	1.0581376256797e-13		NA	NA	NA
hsa-miR-345-5p	MAP3K14	0.639728356429512	0.00013070715719672	-0.382347455234441	4.23425075991379e-06	MirTarget	-0.119214954004009	1.4484437317052e-12		NA	NA	NA
hsa-miR-874-3p	MAP3K14	-0.513415443180424	1.49285755109414e-06	-0.382347455234441	4.23425075991379e-06	MirTarget	-0.132080548476967	7.02111806746594e-07		NA	NA	NA
hsa-let-7d-5p	NGF	0.410958462607207	6.07808182756787e-06	-0.787725123054401	9.35669050853888e-08	MirTarget	-0.171326999284145	0.00225973911147285		NA	NA	NA
hsa-miR-429	NGF	2.84108892259147	3.88520896426515e-64	-0.787725123054401	9.35669050853888e-08	miRanda	-0.12206490353919	1.36541405382157e-05		NA	NA	NA
hsa-miR-146b-5p	PIK3CA	0.631041661167954	6.20366593452965e-08	-0.881957552231161	1.15529457057533e-22	mirMAP	-0.10172531442561	0.000163300940659646		NA	NA	NA
hsa-miR-148a-5p	PIK3CA	0.572692271754695	2.14306251522796e-06	-0.881957552231161	1.15529457057533e-22	mirMAP	-0.111623090383025	1.82115916734019e-05		NA	NA	NA
hsa-miR-200b-3p	PIK3CA	2.11744072703209	1.66710572104191e-43	-0.881957552231161	1.15529457057533e-22	TargetScan	-0.164394431071602	1.25931440199374e-17		NA	NA	NA
hsa-miR-361-5p	PIK3CA	-0.0996867547900457	0.095428250126326	-0.881957552231161	1.15529457057533e-22	mirMAP	-0.28523073173792	1.02307804662151e-07		NA	NA	NA
hsa-miR-96-5p	PIK3CA	3.24596558166606	1.92296159041707e-98	-0.881957552231161	1.15529457057533e-22	TargetScan	-0.158039482109614	1.06514304964241e-18		NA	NA	NA
hsa-miR-30b-3p	PIK3CD	-0.536462824497982	2.41814659272548e-05	-0.316904328019809	0.0048026997053421	MirTarget	-0.12656414985523	3.07110294580941e-05		NA	NA	NA
hsa-miR-484	PIK3CD	0.349444060004737	0.00154491249625173	-0.316904328019809	0.0048026997053421	MirTarget;miRNATAP	-0.141552727299567	4.96089022907138e-05		NA	NA	NA
hsa-miR-103a-3p	PIK3R1	0.610673390034345	1.63113920514646e-12	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.516011898515825	9.39970675304441e-26		NA	NA	NA
hsa-miR-106b-5p	PIK3R1	1.22477789913175	2.31787213143326e-32	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.458684807618424	6.41212047089543e-31		NA	NA	NA
hsa-miR-107	PIK3R1	0.678998026350662	2.56224148930538e-16	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRanda;miRNATAP	-0.564782368968385	1.29413413077175e-28		NA	NA	NA
hsa-miR-128-3p	PIK3R1	0.90296715955238	9.925204823863e-23	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.464882086210543	2.18929508374026e-24	25962360	miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients	worse prognosis;progression	liver cancer
hsa-miR-1301-3p	PIK3R1	1.80754972811286	2.96809840886499e-36	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.312737279865189	3.51588268231222e-28		NA	NA	NA
hsa-miR-15a-5p	PIK3R1	0.812445324157528	4.50263417099822e-20	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.467053807879393	1.27196995879228e-22		NA	NA	NA
hsa-miR-15b-5p	PIK3R1	0.788659356634696	1.13678211092534e-11	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.304923263873542	1.52536411684308e-16		NA	NA	NA
hsa-miR-16-2-3p	PIK3R1	0.286355254959005	0.0256946046884474	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.187390623272605	5.18756959426033e-08		NA	NA	NA
hsa-miR-16-5p	PIK3R1	0.46835991343556	1.91125356547776e-06	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.185144677288316	3.4393027748885e-05		NA	NA	NA
hsa-miR-17-5p	PIK3R1	0.599531757298529	1.07318660415906e-05	-1.70627489565512	1.28475917565256e-44	MirTarget;TargetScan;miRNATAP	-0.305623214527227	2.73465966965389e-22		NA	NA	NA
hsa-miR-182-5p	PIK3R1	2.36408084103818	2.60011457600281e-72	-1.70627489565512	1.28475917565256e-44	miRNATAP	-0.209986504782115	4.31661758321545e-12		NA	NA	NA
hsa-miR-185-5p	PIK3R1	0.482334746589337	3.68475879959415e-09	-1.70627489565512	1.28475917565256e-44	miRNATAP	-0.576307293918371	1.92791131730155e-28		NA	NA	NA
hsa-miR-200b-3p	PIK3R1	2.11744072703209	1.66710572104191e-43	-1.70627489565512	1.28475917565256e-44	mirMAP	-0.193888157381114	6.36921236487692e-13		NA	NA	NA
hsa-miR-200c-3p	PIK3R1	2.07038651806183	6.84613386286599e-51	-1.70627489565512	1.28475917565256e-44	mirMAP	-0.257145031020416	2.3912254219973e-18		NA	NA	NA
hsa-miR-20a-5p	PIK3R1	0.44979911120222	0.000602386964327228	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.329404805146422	7.47770247059783e-24		NA	NA	NA
hsa-miR-21-5p	PIK3R1	2.32007501846389	3.08394781855554e-137	-1.70627489565512	1.28475917565256e-44	miRNAWalker2_validate;MirTarget;miRNATAP	-0.442813578327247	2.68375696066295e-30	26676464	PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer	cell migration	breast cancer
hsa-miR-29b-3p	PIK3R1	0.438847962603729	6.46722433236121e-05	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.212535407562809	1.00431864575306e-07		NA	NA	NA
hsa-miR-320b	PIK3R1	0.412787504747938	0.00113457276903985	-1.70627489565512	1.28475917565256e-44	miRNATAP	-0.140552558146201	5.57745902628767e-05		NA	NA	NA
hsa-miR-324-3p	PIK3R1	0.404877731996915	0.000340036423920834	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRNATAP	-0.224592588456891	6.81384539720142e-09		NA	NA	NA
hsa-miR-330-3p	PIK3R1	0.432728362037032	0.00041335506960812	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRNATAP	-0.144041669892523	7.57903802651215e-05		NA	NA	NA
hsa-miR-361-5p	PIK3R1	-0.0996867547900457	0.095428250126326	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRanda;mirMAP;miRNATAP	-0.278078422988115	0.000207710985727821		NA	NA	NA
hsa-miR-429	PIK3R1	2.84108892259147	3.88520896426515e-64	-1.70627489565512	1.28475917565256e-44	mirMAP;miRNATAP	-0.22503499935046	3.34180951947627e-21		NA	NA	NA
hsa-miR-590-3p	PIK3R1	1.27438512890514	1.03164723481469e-23	-1.70627489565512	1.28475917565256e-44	miRanda;mirMAP	-0.239713681587516	7.2007499793076e-12		NA	NA	NA
hsa-miR-590-5p	PIK3R1	0.746515607868274	8.51300479640125e-09	-1.70627489565512	1.28475917565256e-44	MirTarget;PITA;miRanda;miRNATAP	-0.209937562895491	3.68537681569131e-10		NA	NA	NA
hsa-miR-629-3p	PIK3R1	1.25035919247365	3.91361135469024e-14	-1.70627489565512	1.28475917565256e-44	MirTarget	-0.122961236064884	5.54567297669118e-06		NA	NA	NA
hsa-miR-93-5p	PIK3R1	1.01788600209314	1.24312921618126e-21	-1.70627489565512	1.28475917565256e-44	MirTarget;miRNATAP	-0.499295395694502	3.97678732290002e-38		NA	NA	NA
hsa-miR-96-5p	PIK3R1	3.24596558166606	1.92296159041707e-98	-1.70627489565512	1.28475917565256e-44	TargetScan;miRNATAP	-0.245653154038236	3.77424010710224e-23		NA	NA	NA
hsa-miR-126-3p	PIK3R2	-1.17432628002954	1.02041618253013e-20	1.28293433832686	8.5972816204378e-73	miRNAWalker2_validate;miRTarBase	-0.169496363080053	8.52458360518473e-17	21249429;26384552;27578985;26191164;25240815	Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC;MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2	;poor survival;;progression;metastasis	breast cancer;thyroid cancer;bladder cancer;esophageal cancer;liver cancer
hsa-miR-28-5p	PIK3R2	-0.14267073663385	0.0497619246260571	1.28293433832686	8.5972816204378e-73	miRanda	-0.170225138245223	4.06181677270291e-06		NA	NA	NA
hsa-miR-30b-5p	PIK3R2	-0.46540603860146	2.4709940429591e-05	1.28293433832686	8.5972816204378e-73	miRNATAP	-0.111541133552651	3.5447180691879e-06		NA	NA	NA
hsa-miR-30c-5p	PIK3R2	-0.393222674580066	8.06961465717306e-05	1.28293433832686	8.5972816204378e-73	miRNAWalker2_validate;miRNATAP	-0.102854891876324	0.000118472431445014		NA	NA	NA
hsa-miR-30d-5p	PIK3R2	-0.247082219011045	0.00406717930063148	1.28293433832686	8.5972816204378e-73	miRNATAP	-0.135541098242265	1.30568664423737e-05		NA	NA	NA
hsa-miR-320a	PIK3R2	-0.287921276129346	0.00141693637596294	1.28293433832686	8.5972816204378e-73	miRanda	-0.151022063052727	3.16338469232646e-07		NA	NA	NA
hsa-miR-491-5p	PIK3R2	-1.04307210952796	1.14586501470398e-15	1.28293433832686	8.5972816204378e-73	miRanda	-0.116485616092769	7.44579853361516e-09		NA	NA	NA
hsa-miR-181a-5p	PIK3R3	0.635863607630183	6.72486918157744e-11	0.559172960265555	3.98014986716526e-09	MirTarget;miRNATAP	-0.146056981056209	1.20649375988888e-05		NA	NA	NA
hsa-miR-19b-3p	PIK3R3	0.139124391010031	0.255658553872934	0.559172960265555	3.98014986716526e-09	MirTarget;miRNATAP	-0.109224067759979	4.71454242795867e-05		NA	NA	NA
hsa-miR-217	PIK3R3	-0.616728851115349	8.64977119332241e-05	0.559172960265555	3.98014986716526e-09	PITA;miRanda	-0.118432783728797	1.05730160913028e-08		NA	NA	NA
hsa-miR-25-3p	PIK3R3	-0.00546790775985073	0.944061771389468	0.559172960265555	3.98014986716526e-09	MirTarget	-0.129911102729152	0.00226643466666436		NA	NA	NA
hsa-miR-26a-5p	PIK3R3	-0.481180084102235	1.82368246174758e-10	0.559172960265555	3.98014986716526e-09	miRNATAP	-0.28216506702381	5.37056936747542e-11		NA	NA	NA
hsa-miR-374a-5p	PIK3R3	-0.239709888246804	0.00309819667153627	0.559172960265555	3.98014986716526e-09	mirMAP	-0.121442827230575	0.0029020400924295		NA	NA	NA
hsa-miR-374b-5p	PIK3R3	-0.466781429946153	1.17238311619116e-08	0.559172960265555	3.98014986716526e-09	mirMAP	-0.120196538768652	0.00271578207935794		NA	NA	NA
hsa-miR-381-3p	PIK3R3	-1.28028930293369	1.61402949866141e-23	0.559172960265555	3.98014986716526e-09	mirMAP	-0.140767078074606	1.38941193259491e-08		NA	NA	NA
hsa-miR-532-5p	PIK3R3	0.0386976222860582	0.682018574136515	0.559172960265555	3.98014986716526e-09	mirMAP	-0.140279487612118	5.85354025061255e-05		NA	NA	NA
hsa-miR-92a-3p	PIK3R3	-0.342420481092807	0.000732275969501111	0.559172960265555	3.98014986716526e-09	MirTarget;miRNATAP	-0.227757876133252	1.19233380886192e-12		NA	NA	NA
hsa-miR-125a-5p	PIK3R5	-0.635694700253268	3.6703235721638e-11	0.311128035887536	0.0038375952038782	MirTarget;miRanda	-0.280593880513026	8.91996620676494e-14		NA	NA	NA
hsa-miR-182-5p	PIK3R5	2.36408084103818	2.60011457600281e-72	0.311128035887536	0.0038375952038782	MirTarget	-0.108305079676846	2.32094065834864e-05		NA	NA	NA
hsa-let-7f-5p	PPP3CA	0.12216148416417	0.221351291433294	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.102194254433793	0.00165189815382032		NA	NA	NA
hsa-miR-106b-5p	PPP3CA	1.22477789913175	2.31787213143326e-32	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.163746270795427	4.48730421523751e-08		NA	NA	NA
hsa-miR-17-3p	PPP3CA	0.721439431208839	7.95900548819742e-10	-0.544246415257643	5.77237427579346e-09	MirTarget	-0.124078923715287	5.08318296663462e-06		NA	NA	NA
hsa-miR-194-5p	PPP3CA	0.467781870340114	1.0386810618625e-07	-0.544246415257643	5.77237427579346e-09	MirTarget	-0.132376274530416	0.000303144003211118		NA	NA	NA
hsa-miR-20a-5p	PPP3CA	0.44979911120222	0.000602386964327228	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.110326267376209	6.81988772591416e-06		NA	NA	NA
hsa-miR-21-5p	PPP3CA	2.32007501846389	3.08394781855554e-137	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.171857455775929	3.70280677648987e-09		NA	NA	NA
hsa-miR-340-5p	PPP3CA	1.0857159627596	4.94471062546756e-24	-0.544246415257643	5.77237427579346e-09	mirMAP	-0.176067551771713	1.43168876315375e-09		NA	NA	NA
hsa-miR-361-5p	PPP3CA	-0.0996867547900457	0.095428250126326	-0.544246415257643	5.77237427579346e-09	miRanda	-0.244052441662145	8.38230854446672e-06		NA	NA	NA
hsa-miR-93-5p	PPP3CA	1.01788600209314	1.24312921618126e-21	-0.544246415257643	5.77237427579346e-09	miRNATAP	-0.162948227314112	3.15959129159339e-08		NA	NA	NA
hsa-miR-107	PPP3CB	0.678998026350662	2.56224148930538e-16	-0.507852474824067	3.82558012937129e-19	miRanda	-0.128823034238509	4.39638835494672e-08		NA	NA	NA
hsa-miR-146b-5p	PPP3CB	0.631041661167954	6.20366593452965e-08	-0.507852474824067	3.82558012937129e-19	miRanda	-0.171198371090796	2.36585494803099e-25		NA	NA	NA
hsa-miR-15a-5p	PPP3CB	0.812445324157528	4.50263417099822e-20	-0.507852474824067	3.82558012937129e-19	miRNATAP	-0.126089090631579	8.14069089424982e-09		NA	NA	NA
hsa-miR-340-5p	PPP3CB	1.0857159627596	4.94471062546756e-24	-0.507852474824067	3.82558012937129e-19	MirTarget	-0.156446625862705	8.32036945224755e-19		NA	NA	NA
hsa-miR-361-5p	PPP3CB	-0.0996867547900457	0.095428250126326	-0.507852474824067	3.82558012937129e-19	miRanda	-0.218861370922051	6.00579314883281e-11		NA	NA	NA
hsa-miR-101-3p	PPP3R1	-0.126035286271986	0.145997832808138	-0.297052041419911	9.95522907099635e-08	miRNATAP	-0.187171459954337	1.17776284425277e-17		NA	NA	NA
hsa-miR-181c-5p	PPP3R1	0.574847839298605	4.51287502066478e-07	-0.297052041419911	9.95522907099635e-08	MirTarget;miRNATAP	-0.125950184238424	2.66954355100233e-14		NA	NA	NA
hsa-miR-26a-5p	PPP3R1	-0.481180084102235	1.82368246174758e-10	-0.297052041419911	9.95522907099635e-08	MirTarget;miRNATAP	-0.15120972679612	1.94023722332139e-09		NA	NA	NA
hsa-miR-30a-5p	PPP3R1	-0.392489994825279	0.00954894667761676	-0.297052041419911	9.95522907099635e-08	miRNAWalker2_validate;MirTarget;miRNATAP	-0.13382780475557	1.01801426792285e-27		NA	NA	NA
hsa-miR-141-3p	PRKACB	2.99777540204168	1.26370498493024e-78	-0.383846400368397	0.0117591306589187	MirTarget;TargetScan;miRNATAP	-0.14986275424127	3.7367241254854e-07		NA	NA	NA
hsa-miR-17-5p	PRKACB	0.599531757298529	1.07318660415906e-05	-0.383846400368397	0.0117591306589187	TargetScan	-0.167470485926017	1.11326049159611e-05		NA	NA	NA
hsa-miR-18a-5p	PRKACB	0.969066793715868	1.69069796425892e-08	-0.383846400368397	0.0117591306589187	miRNATAP	-0.109828861303179	0.000270889162356874		NA	NA	NA
hsa-miR-19a-3p	PRKACB	0.817507952171848	3.76285090469625e-08	-0.383846400368397	0.0117591306589187	MirTarget;miRNATAP	-0.144307019920445	3.41593280940585e-05		NA	NA	NA
hsa-miR-19b-3p	PRKACB	0.139124391010031	0.255658553872934	-0.383846400368397	0.0117591306589187	miRNAWalker2_validate;MirTarget;miRNATAP	-0.13474256019019	0.00164169207970928		NA	NA	NA
hsa-miR-200b-3p	PRKACB	2.11744072703209	1.66710572104191e-43	-0.383846400368397	0.0117591306589187	MirTarget;TargetScan	-0.128358992363134	6.97422500356901e-05		NA	NA	NA
hsa-miR-200c-3p	PRKACB	2.07038651806183	6.84613386286599e-51	-0.383846400368397	0.0117591306589187	MirTarget;miRNATAP	-0.165596646495394	2.94921644943646e-06		NA	NA	NA
hsa-miR-30d-3p	PRKACB	0.264544633563642	0.00755023189129747	-0.383846400368397	0.0117591306589187	mirMAP	-0.251818481172515	1.82407867076559e-06		NA	NA	NA
hsa-miR-340-5p	PRKACB	1.0857159627596	4.94471062546756e-24	-0.383846400368397	0.0117591306589187	mirMAP	-0.151842813986032	0.001373090709035		NA	NA	NA
hsa-miR-361-5p	PRKACB	-0.0996867547900457	0.095428250126326	-0.383846400368397	0.0117591306589187	miRanda	-0.31917046064862	0.000326749716630808		NA	NA	NA
hsa-miR-362-5p	PRKACB	-0.248676340901797	0.0726089851456282	-0.383846400368397	0.0117591306589187	PITA	-0.175108655019306	3.25359783331258e-06		NA	NA	NA
hsa-miR-532-5p	PRKACB	0.0386976222860582	0.682018574136515	-0.383846400368397	0.0117591306589187	PITA	-0.167904290632964	0.00255889279358267		NA	NA	NA
hsa-miR-93-5p	PRKACB	1.01788600209314	1.24312921618126e-21	-0.383846400368397	0.0117591306589187	miRNAWalker2_validate	-0.337877597223658	9.95580809015501e-13		NA	NA	NA
hsa-miR-107	PRKAR1A	0.678998026350662	2.56224148930538e-16	-0.390912835051463	6.41647291375684e-08	miRanda	-0.119959831304595	5.27363924798668e-05		NA	NA	NA
hsa-miR-155-5p	PRKAR1A	1.09766314984151	4.55650930885814e-15	-0.390912835051463	6.41647291375684e-08	miRNAWalker2_validate	-0.138059655346011	1.13999315375584e-15		NA	NA	NA
hsa-miR-25-3p	PRKAR1A	-0.00546790775985073	0.944061771389468	-0.390912835051463	6.41647291375684e-08	miRNAWalker2_validate	-0.164526077689284	3.07364432032994e-07		NA	NA	NA
hsa-miR-30e-5p	PRKAR1A	0.293491764699475	0.000372291967271834	-0.390912835051463	6.41647291375684e-08	mirMAP	-0.135180536556767	8.0116702940993e-06		NA	NA	NA
hsa-miR-342-3p	PRKAR1B	1.21944481975657	6.81914373001202e-19	-0.14732140348009	0.152647791831157	mirMAP	-0.112544514120357	7.06519559214984e-06		NA	NA	NA
hsa-miR-491-5p	PRKAR1B	-1.04307210952796	1.14586501470398e-15	-0.14732140348009	0.152647791831157	miRanda	-0.157141338101157	3.59668087391003e-09		NA	NA	NA
hsa-miR-625-5p	PRKAR1B	0.728939236913178	5.97591217674307e-08	-0.14732140348009	0.152647791831157	mirMAP	-0.108203525336462	5.55805043371063e-05		NA	NA	NA
hsa-miR-92b-3p	PRKAR1B	1.30248132773644	9.42428674470985e-25	-0.14732140348009	0.152647791831157	miRNATAP	-0.152761919500563	1.27937973337764e-08		NA	NA	NA
hsa-miR-103a-3p	PRKAR2A	0.610673390034345	1.63113920514646e-12	-0.849497621481062	3.89379966434713e-09	miRNAWalker2_validate	-0.598146567510241	4.65664063552882e-27		NA	NA	NA
hsa-miR-106b-5p	PRKAR2A	1.22477789913175	2.31787213143326e-32	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.406481597420149	4.72151259322544e-19		NA	NA	NA
hsa-miR-146b-5p	PRKAR2A	0.631041661167954	6.20366593452965e-08	-0.849497621481062	3.89379966434713e-09	miRanda	-0.273919400111088	8.1738277985017e-11		NA	NA	NA
hsa-miR-148a-5p	PRKAR2A	0.572692271754695	2.14306251522796e-06	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.172687337443351	2.57585400519544e-05		NA	NA	NA
hsa-miR-155-5p	PRKAR2A	1.09766314984151	4.55650930885814e-15	-0.849497621481062	3.89379966434713e-09	miRNAWalker2_validate	-0.172204491888852	8.04193305743878e-07		NA	NA	NA
hsa-miR-17-5p	PRKAR2A	0.599531757298529	1.07318660415906e-05	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.142029585393759	9.67819842669458e-05		NA	NA	NA
hsa-miR-20a-5p	PRKAR2A	0.44979911120222	0.000602386964327228	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.317770709661877	1.62622898454047e-17		NA	NA	NA
hsa-miR-21-5p	PRKAR2A	2.32007501846389	3.08394781855554e-137	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.342627756886755	1.81049457969324e-14		NA	NA	NA
hsa-miR-25-3p	PRKAR2A	-0.00546790775985073	0.944061771389468	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.285901092503133	9.17213733067375e-06		NA	NA	NA
hsa-miR-26a-5p	PRKAR2A	-0.481180084102235	1.82368246174758e-10	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.267807878494749	4.77261329832618e-05		NA	NA	NA
hsa-miR-32-5p	PRKAR2A	1.38676603945192	2.29428299685976e-34	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.21153205232007	4.9203673053638e-07		NA	NA	NA
hsa-miR-320a	PRKAR2A	-0.287921276129346	0.00141693637596294	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.18245994665913	0.00100676430812175		NA	NA	NA
hsa-miR-361-5p	PRKAR2A	-0.0996867547900457	0.095428250126326	-0.849497621481062	3.89379966434713e-09	miRanda	-0.7784380971036	6.37302709255488e-21		NA	NA	NA
hsa-miR-3913-5p	PRKAR2A	0.71890413546147	2.61153227160465e-13	-0.849497621481062	3.89379966434713e-09	mirMAP	-0.287042647112917	9.2693710730762e-09		NA	NA	NA
hsa-let-7f-1-3p	PRKAR2B	0.37532726250321	0.00156021688753682	-2.21081590198765	1.60222507436243e-42	mirMAP	-0.146699506826546	0.0033120259534399		NA	NA	NA
hsa-miR-107	PRKAR2B	0.678998026350662	2.56224148930538e-16	-2.21081590198765	1.60222507436243e-42	miRanda	-0.229588564142726	0.000988045506014625		NA	NA	NA
hsa-miR-200b-3p	PRKAR2B	2.11744072703209	1.66710572104191e-43	-2.21081590198765	1.60222507436243e-42	TargetScan	-0.280997010338504	3.04124526480141e-15		NA	NA	NA
hsa-miR-200c-3p	PRKAR2B	2.07038651806183	6.84613386286599e-51	-2.21081590198765	1.60222507436243e-42	miRNATAP	-0.292941274401131	8.32765818000856e-14		NA	NA	NA
hsa-miR-32-5p	PRKAR2B	1.38676603945192	2.29428299685976e-34	-2.21081590198765	1.60222507436243e-42	miRNATAP	-0.298798035399556	1.17712386857873e-09		NA	NA	NA
hsa-miR-429	PRKAR2B	2.84108892259147	3.88520896426515e-64	-2.21081590198765	1.60222507436243e-42	PITA;miRanda;miRNATAP	-0.297037447890531	4.91028637474137e-21		NA	NA	NA
hsa-miR-450b-5p	PRKAR2B	0.781564228875267	3.90462514315383e-11	-2.21081590198765	1.60222507436243e-42	mirMAP;miRNATAP	-0.15718172389387	0.00131925936989063		NA	NA	NA
hsa-miR-590-3p	PRKAR2B	1.27438512890514	1.03164723481469e-23	-2.21081590198765	1.60222507436243e-42	miRNAWalker2_validate;miRanda	-0.304016287373841	5.72972948135857e-11		NA	NA	NA
hsa-miR-9-5p	PRKAR2B	0.734772328078424	0.00261982843636383	-2.21081590198765	1.60222507436243e-42	miRNATAP	-0.123752557077492	1.86061068432454e-07		NA	NA	NA
hsa-miR-92b-3p	PRKAR2B	1.30248132773644	9.42428674470985e-25	-2.21081590198765	1.60222507436243e-42	miRNATAP	-0.28511576575796	1.35261141577019e-10		NA	NA	NA
hsa-miR-182-5p	PRKX	2.36408084103818	2.60011457600281e-72	-0.32229806441307	0.0153896096972611	mirMAP	-0.175194994974604	2.67502751484288e-08		NA	NA	NA
hsa-miR-29b-3p	PRKX	0.438847962603729	6.46722433236121e-05	-0.32229806441307	0.0153896096972611	mirMAP	-0.120330213613139	0.0037387071410825		NA	NA	NA
hsa-miR-29c-3p	PRKX	-0.0652732378039769	0.563774115756922	-0.32229806441307	0.0153896096972611	mirMAP	-0.38827959473025	7.47361121556913e-23		NA	NA	NA
hsa-miR-375	PRKX	2.09893673049766	1.68351780396203e-16	-0.32229806441307	0.0153896096972611	miRNAWalker2_validate;miRanda	-0.207392873270567	7.07421795114455e-35		NA	NA	NA
hsa-miR-625-3p	PRKX	0.0779480073849017	0.444334811113011	-0.32229806441307	0.0153896096972611	mirMAP	-0.146145038207053	0.00114969241015916		NA	NA	NA
hsa-miR-193a-3p	TNFRSF10C	0.310617999804917	0.00477640270974957	-0.0741066334246631	0.62821098912956	miRanda	-0.195687289553461	3.89035100008298e-05		NA	NA	NA
hsa-miR-340-5p	TNFRSF10D	1.0857159627596	4.94471062546756e-24	-2.21925405536116	3.81400561428284e-48	mirMAP	-0.149104609865255	0.00305502578450019		NA	NA	NA
hsa-miR-590-3p	TNFRSF10D	1.27438512890514	1.03164723481469e-23	-2.21925405536116	3.81400561428284e-48	miRanda	-0.26076122341674	3.34240440642948e-09		NA	NA	NA
hsa-miR-590-5p	TNFRSF10D	0.746515607868274	8.51300479640125e-09	-2.21925405536116	3.81400561428284e-48	miRanda	-0.146941086633069	0.000532817357731842		NA	NA	NA
hsa-miR-7-1-3p	TNFRSF10D	0.686579567507582	1.20731554448806e-07	-2.21925405536116	3.81400561428284e-48	mirMAP	-0.366697147958665	1.25437324946942e-18		NA	NA	NA
hsa-miR-361-5p	TNFSF10	-0.0996867547900457	0.095428250126326	-0.371440534710903	0.00739854033800971	miRanda	-0.460395837819847	1.02300973229871e-08		NA	NA	NA
hsa-miR-455-5p	TNFSF10	0.284641224662773	0.0357572339594277	-0.371440534710903	0.00739854033800971	miRanda	-0.163295270434549	3.10292271839683e-06		NA	NA	NA
hsa-miR-98-5p	TNFSF10	0.656336869298973	9.03113188590466e-15	-0.371440534710903	0.00739854033800971	miRNAWalker2_validate	-0.371869472099461	1.42448937706376e-11		NA	NA	NA
hsa-miR-324-3p	TRADD	0.404877731996915	0.000340036423920834	0.449149397263207	2.76533696120627e-06	miRNATAP	-0.176248272366902	1.15041896326237e-09		NA	NA	NA
hsa-miR-106b-5p	XIAP	1.22477789913175	2.31787213143326e-32	-0.0572632117960499	0.337308374738279	miRNATAP	-0.164399803151626	1.10885313299606e-18		NA	NA	NA
hsa-miR-140-3p	XIAP	-1.25844395244141	5.29222651039892e-33	-0.0572632117960499	0.337308374738279	mirMAP	-0.175849683596678	4.89061522526325e-22		NA	NA	NA
hsa-miR-146b-5p	XIAP	0.631041661167954	6.20366593452965e-08	-0.0572632117960499	0.337308374738279	mirMAP;miRNATAP	-0.159991507133537	4.74881632481789e-21		NA	NA	NA
hsa-miR-17-5p	XIAP	0.599531757298529	1.07318660415906e-05	-0.0572632117960499	0.337308374738279	miRNAWalker2_validate;TargetScan	-0.133341945269304	6.31942971165112e-20		NA	NA	NA
hsa-miR-181a-5p	XIAP	0.635863607630183	6.72486918157744e-11	-0.0572632117960499	0.337308374738279	miRNAWalker2_validate;miRTarBase;mirMAP	-0.158928439124698	8.20262640164062e-15		NA	NA	NA
hsa-miR-181b-5p	XIAP	1.22749257795094	1.21998198830919e-27	-0.0572632117960499	0.337308374738279	miRNAWalker2_validate;miRTarBase;mirMAP	-0.143863195368819	6.92537429724419e-17		NA	NA	NA
hsa-miR-19a-3p	XIAP	0.817507952171848	3.76285090469625e-08	-0.0572632117960499	0.337308374738279	mirMAP	-0.103112921623755	1.53894494824873e-14		NA	NA	NA
hsa-miR-19b-1-5p	XIAP	0.647704962003062	3.07687667945597e-07	-0.0572632117960499	0.337308374738279	MirTarget	-0.13308977349311	2.8869452185803e-17		NA	NA	NA
hsa-miR-20a-5p	XIAP	0.44979911120222	0.000602386964327228	-0.0572632117960499	0.337308374738279	miRNATAP	-0.200905990933434	3.22421053196709e-42		NA	NA	NA
hsa-miR-25-3p	XIAP	-0.00546790775985073	0.944061771389468	-0.0572632117960499	0.337308374738279	mirMAP	-0.178365306123466	8.69234553825738e-12		NA	NA	NA
hsa-miR-27a-3p	XIAP	0.388496361379095	1.42373532086331e-05	-0.0572632117960499	0.337308374738279	miRNATAP	-0.146521380961922	8.74015744954972e-11	26662313	miR 27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK SMAC/DIABLO XIAP axis; After further investigation we indicated that the knockdown of miR-27a promoted the apoptosis via mitochondrial pathway in T-47D cells treated with CDDP depending on the BAK-second mitochondria-derived activator of caspase/direct IAP binding protein with low pI SMAC/DIABLO-X-linked inhibitor of apoptosis XIAP axis		breast cancer
hsa-miR-27b-3p	XIAP	-0.0796803270437447	0.410503155574393	-0.0572632117960499	0.337308374738279	miRNATAP	-0.137918346860995	4.71201482825092e-11		NA	NA	NA
hsa-miR-340-5p	XIAP	1.0857159627596	4.94471062546756e-24	-0.0572632117960499	0.337308374738279	mirMAP;miRNATAP	-0.127382401281156	3.40040901491278e-12		NA	NA	NA
hsa-miR-361-3p	XIAP	-0.0370446538644886	0.624902392829872	-0.0572632117960499	0.337308374738279	mirMAP	-0.168890865663792	3.66560347189809e-10		NA	NA	NA
hsa-miR-361-5p	XIAP	-0.0996867547900457	0.095428250126326	-0.0572632117960499	0.337308374738279	miRanda	-0.23192032963789	1.40068436460593e-11		NA	NA	NA
hsa-miR-500a-5p	XIAP	0.209805801129289	0.119177819862398	-0.0572632117960499	0.337308374738279	mirMAP;miRNATAP	-0.129892682453372	7.13179467986375e-18		NA	NA	NA
hsa-miR-532-5p	XIAP	0.0386976222860582	0.682018574136515	-0.0572632117960499	0.337308374738279	mirMAP	-0.163157908700779	2.48323565162108e-14		NA	NA	NA
hsa-miR-92a-3p	XIAP	-0.342420481092807	0.000732275969501111	-0.0572632117960499	0.337308374738279	mirMAP	-0.147544420242899	1.12077603559433e-13		NA	NA	NA