miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p BMP2 -0.0173325743795476 0.957121175716163 -0.349131594135307 0.362678267294403 miRNATAP -0.13733219575815 0.0353378641266495 NA NA NA hsa-miR-17-5p BMP2 -0.157610353661662 0.816482306226182 -0.349131594135307 0.362678267294403 TargetScan -0.179082884567471 0.0139285781243937 NA NA NA hsa-miR-20a-5p BMP2 -0.144866934484993 0.821935004046787 -0.349131594135307 0.362678267294403 miRNATAP -0.172086381139174 0.0189386691781264 NA NA NA hsa-miR-3065-5p BMP2 0.0353875622402079 0.87439664677472 -0.349131594135307 0.362678267294403 mirMAP -0.271238334102083 2.81263836360285e-06 NA NA NA hsa-miR-335-3p BMP2 0.248463575981435 0.607467452476391 -0.349131594135307 0.362678267294403 mirMAP -0.11624777686982 0.0240386766712432 NA NA NA hsa-miR-106a-5p BMP7 -0.0173325743795476 0.957121175716163 -0.157866739936391 0.74331649753086 mirMAP -0.213107626919806 0.0497769925486375 NA NA NA hsa-miR-17-5p BMP7 -0.157610353661662 0.816482306226182 -0.157866739936391 0.74331649753086 mirMAP -0.30309517063183 0.0123654622246275 NA NA NA hsa-miR-20b-5p BMP7 0.139675436887229 0.712045551459328 -0.157866739936391 0.74331649753086 mirMAP -0.167918446086084 0.0420527528441079 NA NA NA hsa-miR-338-3p BMP7 -0.207072603155625 0.729900444872807 -0.157866739936391 0.74331649753086 miRanda -0.411479827858547 0.00118108686362591 NA NA NA hsa-miR-342-3p BMP7 -0.148663039748597 0.77456212196831 -0.157866739936391 0.74331649753086 miRNAWalker2_validate;miRTarBase;miRanda -0.564549946965806 3.57247612956533e-05 NA NA NA hsa-miR-362-3p BMP7 -0.242005568209823 0.177516344352304 -0.157866739936391 0.74331649753086 miRanda -0.30784906106111 0.0207029789815096 NA NA NA hsa-miR-450b-5p BMP7 -0.092442822969625 0.746771401439922 -0.157866739936391 0.74331649753086 mirMAP -0.312735833754277 0.0324802930889376 NA NA NA hsa-miR-28-5p CTNNB1 -0.0287489538758985 0.954294248941519 -0.0520575435704078 0.932678873207757 miRanda -0.182072912507331 0.000829385072717343 NA NA NA hsa-miR-15a-5p EPB41L5 -0.149822297617648 0.791626259098658 0.0423460332037195 0.87370172678371 MirTarget -0.109946763271783 0.00452899966676662 NA NA NA hsa-miR-26b-5p EPB41L5 -0.117592484582318 0.865215390375312 0.0423460332037195 0.87370172678371 mirMAP -0.103554029116114 0.0402137076946522 NA NA NA hsa-miR-139-5p FAM83D 0.0211504809184522 0.958560830348124 0.220066859990475 0.553614980390128 miRanda -0.127477591893435 0.0137660511132003 NA NA NA hsa-miR-429 FAM83D 0.415614548843864 0.504839831319045 0.220066859990475 0.553614980390128 miRanda -0.128849987303415 2.89649716657933e-07 NA NA NA hsa-let-7a-3p FGFR2 -0.0650394051297765 0.86393537395343 0.267989898960385 0.506088688212394 miRNATAP -0.403668699840633 0.000151473399712384 NA NA NA hsa-let-7b-3p FGFR2 -0.0700069758343513 0.815134271483468 0.267989898960385 0.506088688212394 mirMAP;miRNATAP -0.309687251123528 0.00423048135274253 NA NA NA hsa-miR-107 FGFR2 -0.00974460013293577 0.983440660767162 0.267989898960385 0.506088688212394 PITA;miRanda -0.398153526215925 0.00027439034373613 NA NA NA hsa-miR-126-5p FGFR2 -0.124081421741405 0.812001894056048 0.267989898960385 0.506088688212394 mirMAP;miRNATAP -0.403452572621652 6.82252178653857e-05 NA NA NA hsa-miR-146b-5p FGFR2 -0.16404741006667 0.793111938333795 0.267989898960385 0.506088688212394 miRanda -0.146244445164253 0.022817620173302 NA NA NA hsa-miR-186-5p FGFR2 -0.0960063082183451 0.868141302182904 0.267989898960385 0.506088688212394 miRNAWalker2_validate -0.471854892718397 2.53033898213571e-05 NA NA NA hsa-miR-193a-3p FGFR2 -0.00832669565946897 0.972913473583695 0.267989898960385 0.506088688212394 miRanda -0.184992348766107 0.00659604280779591 NA NA NA hsa-miR-19b-1-5p FGFR2 -0.0990370702383485 0.702458888091178 0.267989898960385 0.506088688212394 miRNAWalker2_validate;miRTarBase -0.4345309219133 4.77765562006864e-09 NA NA NA hsa-miR-324-5p FGFR2 0.0519393001587378 0.894960490401887 0.267989898960385 0.506088688212394 miRanda -0.24680525694008 0.000127710806173706 NA NA NA hsa-miR-338-3p FGFR2 -0.207072603155625 0.729900444872807 0.267989898960385 0.506088688212394 miRanda;miRNATAP -0.263518769420772 0.000141261313872914 NA NA NA hsa-miR-423-3p FGFR2 -0.0301151989336859 0.953314752994757 0.267989898960385 0.506088688212394 PITA;miRNATAP -0.233949308012158 0.00330874395567353 NA NA NA hsa-miR-590-3p FGFR2 -0.216104759768254 0.330588330096734 0.267989898960385 0.506088688212394 miRanda -0.311141579023723 6.00872154446622e-05 NA NA NA hsa-miR-628-5p FGFR2 -0.123325699413905 0.502680700626442 0.267989898960385 0.506088688212394 PITA;miRNATAP -0.568329203893148 5.54144600332728e-07 NA NA NA hsa-miR-130b-3p FOXF2 -0.0723220500487693 0.847618325912693 -0.464114505588153 0.096003092879201 miRNATAP -0.111927000474606 0.0385945280592391 NA NA NA hsa-miR-139-5p GSK3B 0.0211504809184522 0.958560830348124 0.0717794012366522 0.868558045048874 mirMAP -0.100160771461377 1.20519675407331e-06 NA NA NA hsa-let-7a-3p HGF -0.0650394051297765 0.86393537395343 0.392331839009741 0.210412010515468 mirMAP -0.542810606112975 9.43474905006386e-05 NA NA NA hsa-let-7b-3p HGF -0.0700069758343513 0.815134271483468 0.392331839009741 0.210412010515468 mirMAP -0.566084083307672 5.71312900566914e-05 NA NA NA hsa-let-7f-1-3p HGF 0.0110483999860613 0.939074494255471 0.392331839009741 0.210412010515468 mirMAP -0.343222022733725 0.00407354838842982 NA NA NA hsa-miR-126-5p HGF -0.124081421741405 0.812001894056048 0.392331839009741 0.210412010515468 mirMAP -0.30252476535825 0.0230197315111662 NA NA NA hsa-miR-129-5p HGF 0.0614802474382699 0.797910867354826 0.392331839009741 0.210412010515468 mirMAP -0.176315710478523 0.00827877952568297 NA NA NA hsa-miR-141-3p HGF 0.166559080202077 0.830499516256997 0.392331839009741 0.210412010515468 MirTarget;TargetScan -0.676636907580645 1.12497659260577e-44 NA NA NA hsa-miR-181a-5p HGF -0.0952743147701067 0.89803512431227 0.392331839009741 0.210412010515468 mirMAP -0.725020652043404 2.96259222943239e-11 NA NA NA hsa-miR-181b-5p HGF -0.164743110284032 0.784712839384427 0.392331839009741 0.210412010515468 mirMAP -0.706743272553437 2.55576874895847e-13 NA NA NA hsa-miR-181c-5p HGF 0.181344386779278 0.638470017100076 0.392331839009741 0.210412010515468 mirMAP -0.655855093153665 2.2633028663108e-09 NA NA NA hsa-miR-200a-3p HGF 0.321954194605755 0.636347043136301 0.392331839009741 0.210412010515468 MirTarget -0.565686401356116 7.92905519776232e-34 NA NA NA hsa-miR-203a-3p HGF 0.553445956735887 0.586179706179699 0.392331839009741 0.210412010515468 MirTarget -0.307285226038045 3.93961477705831e-13 NA NA NA hsa-miR-224-3p HGF 0.145844090429588 0.587621188119518 0.392331839009741 0.210412010515468 mirMAP -0.425091238537773 2.95664734683986e-12 NA NA NA hsa-miR-26b-5p HGF -0.117592484582318 0.865215390375312 0.392331839009741 0.210412010515468 MirTarget;miRNATAP -0.860917332821866 3.45908003051971e-09 NA NA NA hsa-miR-30b-5p HGF 0.0910318704175115 0.887931707578603 0.392331839009741 0.210412010515468 mirMAP -0.745493458613655 1.87319496040024e-08 NA NA NA hsa-miR-30c-5p HGF -0.0620621352101356 0.927045599790469 0.392331839009741 0.210412010515468 mirMAP -0.865812342797699 1.59173376397441e-11 NA NA NA hsa-miR-30d-5p HGF 0.140644455118766 0.878497207134646 0.392331839009741 0.210412010515468 mirMAP -1.14363195060416 9.73383073509946e-22 NA NA NA hsa-miR-30e-5p HGF -0.0527937059666606 0.953772950870221 0.392331839009741 0.210412010515468 mirMAP -1.43246567275328 1.85577963409756e-29 NA NA NA hsa-miR-335-3p HGF 0.248463575981435 0.607467452476391 0.392331839009741 0.210412010515468 mirMAP -0.296203494255056 9.94228604078741e-07 NA NA NA hsa-miR-33a-3p HGF 0.108471046357151 0.54723623490155 0.392331839009741 0.210412010515468 mirMAP -0.709152405531059 2.95855303843078e-15 NA NA NA hsa-miR-34c-5p HGF -0.296356384394638 0.240599245560279 0.392331839009741 0.210412010515468 miRanda -0.179064697968714 0.0198975045718808 NA NA NA hsa-miR-421 HGF -0.304872393419454 0.110219789564227 0.392331839009741 0.210412010515468 miRanda -0.423367559608824 7.10463304822239e-05 NA NA NA hsa-miR-429 HGF 0.415614548843864 0.504839831319045 0.392331839009741 0.210412010515468 miRanda -0.520793016805242 9.95726908305676e-28 NA NA NA hsa-miR-582-5p HGF -0.315319100655602 0.375256468418586 0.392331839009741 0.210412010515468 PITA -0.41813369111985 1.98992264527824e-05 NA NA NA hsa-miR-590-3p HGF -0.216104759768254 0.330588330096734 0.392331839009741 0.210412010515468 miRanda;mirMAP -0.643510815709232 1.09614685120259e-10 NA NA NA hsa-miR-590-5p HGF -0.11748040817411 0.713387911750096 0.392331839009741 0.210412010515468 miRanda -0.712648418249155 4.67151690440208e-16 NA NA NA hsa-miR-651-5p HGF -0.192960569703135 0.356318184760533 0.392331839009741 0.210412010515468 MirTarget -0.876408480048342 2.87757604471444e-25 NA NA NA hsa-miR-7-1-3p HGF -0.132725495142008 0.67412515459916 0.392331839009741 0.210412010515468 mirMAP -0.580271470067749 8.96109537411397e-08 NA NA NA hsa-miR-944 HGF -0.456233617420337 0.371080282344214 0.392331839009741 0.210412010515468 mirMAP -0.408051827291836 3.7779107870685e-19 NA NA NA hsa-miR-106b-3p HIF1A 0.042357307357479 0.945693995148457 -0.243178518306128 0.654740404951459 miRNAWalker2_validate -0.115876573349366 0.01114041942823 NA NA NA hsa-miR-106b-5p HIF1A -0.048037149600324 0.939905851185041 -0.243178518306128 0.654740404951459 MirTarget -0.22506470406352 5.67731754915871e-08 NA NA NA hsa-miR-107 HIF1A -0.00974460013293577 0.983440660767162 -0.243178518306128 0.654740404951459 miRNAWalker2_validate;miRTarBase;miRanda -0.123422589068387 0.0264755744668062 NA NA NA hsa-miR-151a-3p HIF1A -0.0276192565778519 0.974106294416408 -0.243178518306128 0.654740404951459 MirTarget -0.16533909856988 0.000338305910074446 NA NA NA hsa-miR-20a-5p HIF1A -0.144866934484993 0.821935004046787 -0.243178518306128 0.654740404951459 miRNAWalker2_validate;miRTarBase;MirTarget -0.115406855575695 0.000600547799598935 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A -0.0287489538758985 0.954294248941519 -0.243178518306128 0.654740404951459 miRanda -0.410823482574077 2.0450455286232e-06 NA NA NA hsa-miR-330-3p HIF1A 0.00862581859895206 0.968643104627764 -0.243178518306128 0.654740404951459 MirTarget;PITA -0.100136266436928 0.0170482873133228 NA NA NA hsa-miR-361-5p HIF1A -0.0739340134141884 0.90219495022229 -0.243178518306128 0.654740404951459 miRanda -0.240248110278126 0.00022502129165918 NA NA NA hsa-miR-660-5p HIF1A -0.0274189867663566 0.948900193865296 -0.243178518306128 0.654740404951459 MirTarget -0.138381785632354 0.00119715434144136 NA NA NA hsa-miR-93-5p HIF1A 0.0453689434949922 0.962015102362393 -0.243178518306128 0.654740404951459 MirTarget -0.194707893705988 1.28811205175096e-08 NA NA NA hsa-let-7e-5p HMGA2 0.0835602958433785 0.91388417390088 -0.91849533504878 0.0502548627976744 miRNAWalker2_validate;miRTarBase;MirTarget -0.732830631394279 0.000332285018696133 NA NA NA hsa-let-7f-5p HMGA2 -0.0475717241799885 0.960559611665325 -0.91849533504878 0.0502548627976744 miRNAWalker2_validate;MirTarget -1.10241489007747 2.22093006633086e-05 NA NA NA hsa-let-7g-5p HMGA2 -0.0714665618891566 0.915547203795166 -0.91849533504878 0.0502548627976744 miRNAWalker2_validate;miRTarBase;MirTarget -1.43231422943387 1.29959880262988e-08 21472347;18308936 Furthermore K-Ras and HMGA2 are well known as targets of let-7g; In this study we evaluated the potential role of precursor pre-let-7g in lung cancer cell metastasis focusing on the two targets of let-7g HMGA2 and K-Ras;In let-7g expressing tumors reductions in Ras family and HMGA2 protein levels were detected; Ectopic expression of K-RasG12D largely rescued let-7g mediated tumor suppression whereas ectopic expression of HMGA2 was less effective metastasis; lung cancer;lung cancer hsa-miR-106b-5p HMGA2 -0.048037149600324 0.939905851185041 -0.91849533504878 0.0502548627976744 miRNATAP -0.371955259846065 0.0281497529699039 NA NA NA hsa-miR-141-5p HMGA2 0.195353388204161 0.779956890446414 -0.91849533504878 0.0502548627976744 mirMAP -0.386721730062858 5.04546077064663e-05 NA NA NA hsa-miR-195-3p HMGA2 0.077036049196668 0.606036544424135 -0.91849533504878 0.0502548627976744 mirMAP -0.350116270182091 0.035971646350522 NA NA NA hsa-miR-20b-5p HMGA2 0.139675436887229 0.712045551459328 -0.91849533504878 0.0502548627976744 miRNATAP -0.302366166322021 0.000973404425265467 NA NA NA hsa-miR-23b-3p HMGA2 -0.0443331968000038 0.952861988607198 -0.91849533504878 0.0502548627976744 mirMAP -0.866480952730137 0.000675818768235312 NA NA NA hsa-miR-29b-2-5p HMGA2 0.037221791025476 0.928740538097238 -0.91849533504878 0.0502548627976744 mirMAP -1.28292888520437 2.32883058282611e-25 NA NA NA hsa-miR-30b-5p HMGA2 0.0910318704175115 0.887931707578603 -0.91849533504878 0.0502548627976744 mirMAP -0.727949169792506 0.00050423325666359 NA NA NA hsa-miR-30c-5p HMGA2 -0.0620621352101356 0.927045599790469 -0.91849533504878 0.0502548627976744 mirMAP -1.06860209233637 1.32355981439901e-07 NA NA NA hsa-miR-30d-3p HMGA2 0.0968515976784659 0.628626194035546 -0.91849533504878 0.0502548627976744 MirTarget -0.82018709894483 6.65963368294546e-06 NA NA NA hsa-miR-30d-5p HMGA2 0.140644455118766 0.878497207134646 -0.91849533504878 0.0502548627976744 mirMAP -1.48013543504836 5.93879658627237e-15 NA NA NA hsa-miR-30e-3p HMGA2 -0.0508637443239834 0.955400191242043 -0.91849533504878 0.0502548627976744 MirTarget -1.74148468984049 2.91502040569628e-13 NA NA NA hsa-miR-30e-5p HMGA2 -0.0527937059666606 0.953772950870221 -0.91849533504878 0.0502548627976744 mirMAP -1.45238572738576 2.51760507887125e-12 NA NA NA hsa-miR-320a HMGA2 -0.173747231083235 0.798491205195337 -0.91849533504878 0.0502548627976744 mirMAP -0.59904315494574 0.00403891079569854 NA NA NA hsa-miR-326 HMGA2 0.205057351537636 0.369519648083496 -0.91849533504878 0.0502548627976744 miRNATAP -0.229170838040218 0.047601931563562 NA NA NA hsa-miR-330-3p HMGA2 0.00862581859895206 0.968643104627764 -0.91849533504878 0.0502548627976744 mirMAP -0.728029469344746 1.4280925148101e-05 NA NA NA hsa-miR-34a-5p HMGA2 -0.000521071722690003 0.999263299468147 -0.91849533504878 0.0502548627976744 miRNAWalker2_validate -0.570917515229347 0.000926842607230156 18803879 miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making poor survival;differentiation gastric cancer hsa-miR-361-5p HMGA2 -0.0739340134141884 0.90219495022229 -0.91849533504878 0.0502548627976744 PITA;miRanda -0.596503583657962 0.0236624437529962 NA NA NA hsa-miR-497-5p HMGA2 0.0791284408654014 0.774580571816321 -0.91849533504878 0.0502548627976744 MirTarget -0.499552665018573 0.00467938635674173 NA NA NA hsa-miR-508-3p HMGA2 -0.118311431713694 0.69347905773631 -0.91849533504878 0.0502548627976744 PITA;miRNATAP -0.245514965186331 0.00496568976326385 NA NA NA hsa-miR-532-5p HMGA2 0.034875850977711 0.959938937610425 -0.91849533504878 0.0502548627976744 mirMAP -0.410653335437519 0.0279884123983018 NA NA NA hsa-miR-664a-3p HMGA2 0.0401159915820761 0.916604143060055 -0.91849533504878 0.0502548627976744 mirMAP -1.44373608964992 1.77731563841952e-14 NA NA NA hsa-miR-664a-5p HMGA2 0.141568051467161 0.360811609440921 -0.91849533504878 0.0502548627976744 MirTarget -1.30634405967042 7.76894197459835e-13 NA NA NA hsa-miR-93-3p HMGA2 0.0563439048260124 0.864013764501036 -0.91849533504878 0.0502548627976744 mirMAP -0.283827579027649 0.0493695679424236 NA NA NA hsa-miR-93-5p HMGA2 0.0453689434949922 0.962015102362393 -0.91849533504878 0.0502548627976744 miRNATAP -0.336142311841825 0.0164038445316638 NA NA NA hsa-miR-98-5p HMGA2 -0.0187922337001103 0.967726266866676 -0.91849533504878 0.0502548627976744 miRNAWalker2_validate;miRTarBase;MirTarget -1.24726972778969 1.48507668416586e-08 17222355;23700794 Here we report that HMGA2 expression in head and neck squamous cell carcinoma HNSCC cells is regulated in part by miRNA-98 miR-98;MicroRNA 98 sensitizes cisplatin resistant human lung adenocarcinoma cells by up regulation of HMGA2; MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells; We found that elevated expression of miR-98 led to a higher sensitivity of A549/DDP cells to cisplatin and the protein level of HMGA2 was clearly up-regulated in both A549/DDP and A549 cells by miR-98; We for the first time demonstrated that the expression of miR-98 increases cells spontaneous apoptosis and sensitizes cells to cisplatin at least in part via HMGA2 up-regulation ; head and neck cancer;lung cancer hsa-miR-26b-5p LEF1 -0.117592484582318 0.865215390375312 -0.0586307723523225 0.797934141807334 miRNATAP -0.274638576592703 0.000542709321878361 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-320a LEF1 -0.173747231083235 0.798491205195337 -0.0586307723523225 0.797934141807334 miRanda;mirMAP -0.14857681648965 0.0389269839680858 NA NA NA hsa-miR-320b LEF1 -0.0988100064360236 0.653009378717132 -0.0586307723523225 0.797934141807334 miRanda;mirMAP -0.1663193228511 0.00218419474879364 NA NA NA hsa-miR-33a-3p LEF1 0.108471046357151 0.54723623490155 -0.0586307723523225 0.797934141807334 miRNATAP -0.161646083992726 0.00116798280053409 NA NA NA hsa-miR-1226-3p LIMS1 -0.102091769985498 0.583173860889186 -0.0274747052976743 0.920959391789894 miRNAWalker2_validate -0.112870049936271 0.00443894432422433 NA NA NA hsa-miR-148b-5p LIMS1 -0.13476724326076 0.433079188046196 -0.0274747052976743 0.920959391789894 MirTarget -0.209076171145331 5.92666851858633e-06 NA NA NA hsa-miR-182-5p LIMS1 0.228221093811289 0.825826914145896 -0.0274747052976743 0.920959391789894 MirTarget;miRNATAP -0.116923567741085 0.000354221880553294 NA NA NA hsa-miR-186-5p LIMS1 -0.0960063082183451 0.868141302182904 -0.0274747052976743 0.920959391789894 mirMAP -0.310036272441736 4.16244978896495e-06 NA NA NA hsa-miR-192-5p LIMS1 -0.110061132233261 0.860218873021243 -0.0274747052976743 0.920959391789894 miRNAWalker2_validate;MirTarget -0.110962262001487 0.00394127356028047 NA NA NA hsa-miR-29b-3p LIMS1 -0.0116608366459126 0.986707629219868 -0.0274747052976743 0.920959391789894 MirTarget;miRNATAP -0.236480586384024 3.67289747531903e-07 NA NA NA hsa-miR-29c-3p LIMS1 -0.0398599630396124 0.961734653751747 -0.0274747052976743 0.920959391789894 MirTarget;miRNATAP -0.205163336874868 2.51753331864112e-05 NA NA NA hsa-miR-30b-5p LIMS1 0.0910318704175115 0.887931707578603 -0.0274747052976743 0.920959391789894 MirTarget -0.30632928037458 6.1337197028823e-07 NA NA NA hsa-miR-30c-5p LIMS1 -0.0620621352101356 0.927045599790469 -0.0274747052976743 0.920959391789894 MirTarget -0.384678814052223 9.49865089811851e-11 NA NA NA hsa-miR-30d-3p LIMS1 0.0968515976784659 0.628626194035546 -0.0274747052976743 0.920959391789894 mirMAP -0.187840523219565 0.000518072218915655 NA NA NA hsa-miR-30d-5p LIMS1 0.140644455118766 0.878497207134646 -0.0274747052976743 0.920959391789894 MirTarget -0.204598537740273 0.00039033700976664 NA NA NA hsa-miR-30e-5p LIMS1 -0.0527937059666606 0.953772950870221 -0.0274747052976743 0.920959391789894 MirTarget -0.339276713116783 4.51019594509668e-08 NA NA NA hsa-miR-32-3p LIMS1 0.109275300940862 0.518933706765513 -0.0274747052976743 0.920959391789894 mirMAP -0.111691588874867 0.00763095315449379 NA NA NA hsa-miR-374a-3p LIMS1 -0.135132082276666 0.849137138527211 -0.0274747052976743 0.920959391789894 mirMAP -0.159039062439653 0.0376980046123985 NA NA NA hsa-miR-429 LIMS1 0.415614548843864 0.504839831319045 -0.0274747052976743 0.920959391789894 miRanda;miRNATAP -0.117618757940531 4.18299972573954e-07 NA NA NA hsa-miR-505-3p LIMS1 -0.161991723870133 0.697860937308622 -0.0274747052976743 0.920959391789894 miRNAWalker2_validate;MirTarget -0.108559554906473 0.0447183749413443 NA NA NA hsa-miR-576-5p LIMS1 -0.154721087610302 0.57104937618374 -0.0274747052976743 0.920959391789894 mirMAP -0.206553317110472 4.15525272925661e-05 NA NA NA hsa-miR-590-3p LIMS1 -0.216104759768254 0.330588330096734 -0.0274747052976743 0.920959391789894 miRNAWalker2_validate;miRanda -0.128623419553762 0.00615717388551463 NA NA NA hsa-miR-96-5p LIMS1 0.253659022880497 0.519928436451318 -0.0274747052976743 0.920959391789894 TargetScan;miRNATAP -0.130763226603743 7.5931476060149e-06 NA NA NA hsa-miR-192-5p LOXL2 -0.110061132233261 0.860218873021243 0.0426045681259328 0.910377150227081 miRNAWalker2_validate -0.180348106199117 6.27015330629637e-05 NA NA NA hsa-miR-28-5p LOXL2 -0.0287489538758985 0.954294248941519 0.0426045681259328 0.910377150227081 miRanda -0.455973906650758 0.000181459548210797 NA NA NA hsa-miR-361-5p LOXL2 -0.0739340134141884 0.90219495022229 0.0426045681259328 0.910377150227081 miRanda -0.53628682071833 2.61457157430625e-09 NA NA NA hsa-let-7a-5p LOXL3 -0.0853495373838147 0.935969055203681 0.0879409408204253 0.626496844021367 miRNATAP -0.677142851623546 6.3482597980584e-13 NA NA NA hsa-let-7b-5p LOXL3 -0.0551576054511145 0.954518641843015 0.0879409408204253 0.626496844021367 miRNATAP -0.357945759871693 1.40449840241339e-06 NA NA NA hsa-let-7d-5p LOXL3 0.0329922020858602 0.954344308800577 0.0879409408204253 0.626496844021367 miRNATAP -0.296174723599798 0.000110641100889766 NA NA NA hsa-let-7e-5p LOXL3 0.0835602958433785 0.91388417390088 0.0879409408204253 0.626496844021367 miRNATAP -0.355025136807635 4.11980245334075e-08 NA NA NA hsa-let-7f-5p LOXL3 -0.0475717241799885 0.960559611665325 0.0879409408204253 0.626496844021367 miRNATAP -0.479446558602111 6.04991150307244e-09 NA NA NA hsa-let-7g-5p LOXL3 -0.0714665618891566 0.915547203795166 0.0879409408204253 0.626496844021367 miRNATAP -0.587743182295897 1.55169135865329e-13 NA NA NA hsa-miR-125a-5p LOXL3 0.152419702400914 0.82034906564275 0.0879409408204253 0.626496844021367 PITA;miRanda -0.24189516780015 5.781791505839e-05 NA NA NA hsa-miR-2110 LOXL3 -0.287047175354765 0.0530318197575401 0.0879409408204253 0.626496844021367 miRNATAP -0.363426012396243 4.26225317316907e-13 NA NA NA hsa-miR-320a LOXL3 -0.173747231083235 0.798491205195337 0.0879409408204253 0.626496844021367 miRanda -0.376931169233166 9.87048192306687e-09 NA NA NA hsa-miR-320b LOXL3 -0.0988100064360236 0.653009378717132 0.0879409408204253 0.626496844021367 miRanda -0.242913332761397 1.19866473924613e-06 NA NA NA hsa-miR-34a-5p LOXL3 -0.000521071722690003 0.999263299468147 0.0879409408204253 0.626496844021367 MirTarget;miRNATAP -0.400597917013039 9.32832039663351e-14 NA NA NA hsa-miR-942-5p LOXL3 -0.199586927483347 0.42605395434481 0.0879409408204253 0.626496844021367 MirTarget -0.178341718390901 0.000129387753117133 NA NA NA hsa-miR-101-3p NOG -0.056091234765713 0.952965033672988 0.699382095155775 0.065682628172235 miRNATAP -0.349607670488129 0.0334871174365726 NA NA NA hsa-miR-148b-3p NOG 0.00958177046906972 0.985161914782641 0.699382095155775 0.065682628172235 MirTarget -0.708032615499654 1.42843964112713e-06 NA NA NA hsa-miR-186-5p NOG -0.0960063082183451 0.868141302182904 0.699382095155775 0.065682628172235 MirTarget;miRNATAP -0.574515041812962 0.000167076298016788 NA NA NA hsa-miR-200b-3p NOG 0.338618480110268 0.658564567688223 0.699382095155775 0.065682628172235 MirTarget;TargetScan -0.308168227388684 3.9233328304032e-08 NA NA NA hsa-miR-200c-3p NOG 0.142496959369563 0.888101765131391 0.699382095155775 0.065682628172235 MirTarget;miRNATAP -0.376049889176797 2.18212060301929e-09 NA NA NA hsa-miR-26b-3p NOG -0.048011917257385 0.881505919985841 0.699382095155775 0.065682628172235 MirTarget -0.371766556975879 0.000976875158835306 NA NA NA hsa-miR-3607-3p NOG 0.00708543650532656 0.982275296685967 0.699382095155775 0.065682628172235 MirTarget;miRNATAP -0.237259666257936 0.00365848495964816 NA NA NA hsa-miR-429 NOG 0.415614548843864 0.504839831319045 0.699382095155775 0.065682628172235 MirTarget;PITA;miRanda;miRNATAP -0.255898504627446 1.09673461633081e-06 NA NA NA hsa-miR-582-3p NOG -0.339268932569532 0.602021103422666 0.699382095155775 0.065682628172235 PITA;miRNATAP -0.486313947844228 3.15417877831524e-07 NA NA NA hsa-miR-101-3p NOTCH1 -0.056091234765713 0.952965033672988 -0.152124642572002 0.746458012909484 MirTarget -0.144777408795411 0.0294490692942618 NA NA NA hsa-miR-18a-3p NOTCH1 -0.316631209375323 0.123775439738554 -0.152124642572002 0.746458012909484 MirTarget -0.107047863569522 0.00100601356781471 NA NA NA hsa-miR-28-5p NOTCH1 -0.0287489538758985 0.954294248941519 -0.152124642572002 0.746458012909484 miRanda -0.369077331402684 9.33153738807782e-05 NA NA NA hsa-miR-30b-5p NOTCH1 0.0910318704175115 0.887931707578603 -0.152124642572002 0.746458012909484 miRNATAP -0.117140312197032 0.0389913891192242 NA NA NA hsa-miR-32-5p NOTCH1 -0.0537991724998346 0.890779632696834 -0.152124642572002 0.746458012909484 miRNATAP -0.156587251260072 0.000397879604577739 NA NA NA hsa-miR-326 NOTCH1 0.205057351537636 0.369519648083496 -0.152124642572002 0.746458012909484 miRNAWalker2_validate;miRTarBase -0.137378974908137 8.96324701817683e-06 NA NA NA hsa-miR-92b-3p NOTCH1 0.0611040641305207 0.891034855542414 -0.152124642572002 0.746458012909484 miRNATAP -0.134581909960881 0.00301080085178634 NA NA NA hsa-let-7a-3p RBPJ -0.0650394051297765 0.86393537395343 -0.108337591280336 0.766144741122624 MirTarget -0.127309740086128 0.000376213110569551 NA NA NA hsa-miR-15a-5p RBPJ -0.149822297617648 0.791626259098658 -0.108337591280336 0.766144741122624 MirTarget -0.103022608393756 0.000417904387886218 NA NA NA hsa-miR-15b-5p RBPJ -0.0634307049035439 0.913894456387502 -0.108337591280336 0.766144741122624 MirTarget -0.105646020528212 0.00101677688923709 NA NA NA hsa-miR-16-5p RBPJ -0.14946137381698 0.821005492953259 -0.108337591280336 0.766144741122624 MirTarget -0.100348218423993 0.00227408077704841 NA NA NA hsa-miR-21-5p RBPJ -0.0664480432382106 0.95890230763113 -0.108337591280336 0.766144741122624 MirTarget;miRNATAP -0.114349973224149 0.00054498920378864 NA NA NA hsa-miR-92a-3p RBPJ -0.108968141355327 0.912664639509426 -0.108337591280336 0.766144741122624 miRNATAP -0.105250740535353 0.000535337407907056 NA NA NA hsa-let-7a-3p SNAI1 -0.0650394051297765 0.86393537395343 -0.136821049474771 0.503107540515059 miRNATAP -0.165035217982428 0.0455822172080522 NA NA NA hsa-miR-26b-5p SNAI1 -0.117592484582318 0.865215390375312 -0.136821049474771 0.503107540515059 miRNAWalker2_validate -0.270683501838153 0.00191779575288777 NA NA NA hsa-miR-30b-5p SNAI1 0.0910318704175115 0.887931707578603 -0.136821049474771 0.503107540515059 miRTarBase;miRNATAP -0.386788682351388 8.44716320812545e-07 NA NA NA hsa-miR-30c-5p SNAI1 -0.0620621352101356 0.927045599790469 -0.136821049474771 0.503107540515059 miRTarBase;miRNATAP -0.417101890652328 4.933141879555e-08 NA NA NA hsa-miR-30d-5p SNAI1 0.140644455118766 0.878497207134646 -0.136821049474771 0.503107540515059 miRTarBase;miRNATAP -0.629945763211041 6.71587006206153e-19 26501435 miR 30d Blocked Transforming Growth Factor β1 Induced Epithelial Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells; Luciferase activity assay was performed to verify the direct inhibition of Snail by miR-30d; Furthermore Snail was identified as the direct target of miR-30d; Our results revealed that miR-30d functioned as a suppressor of ovarian cancer progression by decreasing Snail expression and thus blocking TGF-β1-induced EMT process suggesting the potentiality of miR-30d analogs to be used as therapeutics for ovarian cancer progression ovarian cancer hsa-miR-30e-5p SNAI1 -0.0527937059666606 0.953772950870221 -0.136821049474771 0.503107540515059 miRTarBase -0.647252090970601 6.51585963855331e-17 NA NA NA hsa-miR-335-5p SNAI1 0.228179825634298 0.407604021226595 -0.136821049474771 0.503107540515059 miRNAWalker2_validate -0.111561584810692 0.0108854006923972 NA NA NA hsa-miR-590-5p SNAI1 -0.11748040817411 0.713387911750096 -0.136821049474771 0.503107540515059 miRanda -0.15154249631799 0.00465970370203214 NA NA NA hsa-miR-107 SNAI2 -0.00974460013293577 0.983440660767162 -0.345874011776945 0.372237274484946 miRanda -0.587951478655937 2.23241515205897e-09 NA NA NA hsa-miR-126-5p SNAI2 -0.124081421741405 0.812001894056048 -0.345874011776945 0.372237274484946 MirTarget -0.200095252463554 0.0311551209498949 NA NA NA hsa-miR-148b-3p SNAI2 0.00958177046906972 0.985161914782641 -0.345874011776945 0.372237274484946 miRNAWalker2_validate -0.5115588617257 1.85198661011602e-07 NA NA NA hsa-miR-182-5p SNAI2 0.228221093811289 0.825826914145896 -0.345874011776945 0.372237274484946 miRNAWalker2_validate;miRNATAP -0.226684880391696 4.11330558077327e-06 NA NA NA hsa-miR-200b-3p SNAI2 0.338618480110268 0.658564567688223 -0.345874011776945 0.372237274484946 TargetScan -0.267184160966678 5.83468454644939e-13 NA NA NA hsa-miR-200c-3p SNAI2 0.142496959369563 0.888101765131391 -0.345874011776945 0.372237274484946 miRNATAP -0.183480437180395 1.58844201912264e-05 NA NA NA hsa-miR-330-3p SNAI2 0.00862581859895206 0.968643104627764 -0.345874011776945 0.372237274484946 PITA -0.244344141932354 0.00118305093009477 NA NA NA hsa-miR-335-3p SNAI2 0.248463575981435 0.607467452476391 -0.345874011776945 0.372237274484946 mirMAP -0.125422480922013 0.00324023238716861 NA NA NA hsa-miR-33a-3p SNAI2 0.108471046357151 0.54723623490155 -0.345874011776945 0.372237274484946 MirTarget -0.326770909713066 3.29484348166007e-07 NA NA NA hsa-miR-375 SNAI2 0.288459374840373 0.617541698938595 -0.345874011776945 0.372237274484946 miRanda -0.160294717693396 1.3349557949902e-06 NA NA NA hsa-miR-421 SNAI2 -0.304872393419454 0.110219789564227 -0.345874011776945 0.372237274484946 miRanda -0.277190656175256 0.000195037380670986 NA NA NA hsa-miR-429 SNAI2 0.415614548843864 0.504839831319045 -0.345874011776945 0.372237274484946 PITA;miRanda;miRNATAP -0.243690996915046 1.98440445952138e-12 NA NA NA hsa-miR-532-5p SNAI2 0.034875850977711 0.959938937610425 -0.345874011776945 0.372237274484946 PITA -0.570320787851888 2.40819282921953e-12 NA NA NA hsa-miR-96-5p SNAI2 0.253659022880497 0.519928436451318 -0.345874011776945 0.372237274484946 miRNATAP -0.21174388168592 1.54578985770895e-06 NA NA NA hsa-miR-1-3p SOX9 0.314931517705573 0.438014941415609 -0.128624677474662 0.745825472812867 MirTarget -0.105386330393545 0.0482633528242291 NA NA NA hsa-miR-101-3p SOX9 -0.056091234765713 0.952965033672988 -0.128624677474662 0.745825472812867 miRNAWalker2_validate;miRNATAP -0.539844940330791 0.000204431201243516 23178713 Ectopic expression of miR-101 significantly inhibited HCC cell proliferation and tumorigenicity by targeting SOX9; Therefore miR-101 may suppress HCC tumor progression by down-regulating SOX9 progression liver cancer hsa-miR-30b-5p SOX9 0.0910318704175115 0.887931707578603 -0.128624677474662 0.745825472812867 MirTarget -0.318002910195815 0.010685542852497 NA NA NA hsa-miR-30c-5p SOX9 -0.0620621352101356 0.927045599790469 -0.128624677474662 0.745825472812867 MirTarget;miRNATAP -0.365035942002407 0.00266402091223478 NA NA NA hsa-miR-30d-5p SOX9 0.140644455118766 0.878497207134646 -0.128624677474662 0.745825472812867 MirTarget;miRNATAP -0.434664007643438 0.000170467688323101 NA NA NA hsa-miR-30e-5p SOX9 -0.0527937059666606 0.953772950870221 -0.128624677474662 0.745825472812867 MirTarget -0.485497322443767 0.000110039719791244 NA NA NA hsa-miR-320a SOX9 -0.173747231083235 0.798491205195337 -0.128624677474662 0.745825472812867 miRanda;miRNATAP -0.277550082459125 0.0250284600790132 NA NA NA hsa-miR-33a-3p SOX9 0.108471046357151 0.54723623490155 -0.128624677474662 0.745825472812867 mirMAP -0.175796869781922 0.0410958416143202 NA NA NA hsa-miR-582-3p SOX9 -0.339268932569532 0.602021103422666 -0.128624677474662 0.745825472812867 PITA;miRNATAP -0.384458473099014 5.81907031889053e-06 NA NA NA hsa-miR-582-5p SOX9 -0.315319100655602 0.375256468418586 -0.128624677474662 0.745825472812867 PITA;miRNATAP -0.335428447645588 0.000227574582108014 NA NA NA hsa-miR-744-5p TGFB1 -0.14726518053716 0.67868601566573 -0.399331426119456 0.404726569206914 miRNAWalker2_validate;miRNATAP -0.229419410482444 6.9384219754003e-06 NA NA NA hsa-miR-107 TGFB2 -0.00974460013293577 0.983440660767162 -0.3344966009348 0.191883995261116 miRanda -0.51939474457829 1.98547903259176e-07 NA NA NA hsa-miR-126-5p TGFB2 -0.124081421741405 0.812001894056048 -0.3344966009348 0.191883995261116 mirMAP -0.25743093726133 0.00599073764101041 NA NA NA hsa-miR-130b-3p TGFB2 -0.0723220500487693 0.847618325912693 -0.3344966009348 0.191883995261116 MirTarget;miRNATAP -0.344962470893237 7.65363506175553e-10 NA NA NA hsa-miR-141-3p TGFB2 0.166559080202077 0.830499516256997 -0.3344966009348 0.191883995261116 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-148a-3p TGFB2 0.0215675426957205 0.982874395895126 -0.3344966009348 0.191883995261116 MirTarget;miRNATAP -0.286009485859132 8.40361643900754e-05 NA NA NA hsa-miR-148b-3p TGFB2 0.00958177046906972 0.985161914782641 -0.3344966009348 0.191883995261116 MirTarget -0.76533615341931 3.3613707731401e-15 NA NA NA hsa-miR-149-5p TGFB2 0.498268187315058 0.352678655418625 -0.3344966009348 0.191883995261116 MirTarget;miRNATAP -0.268302009449797 3.19540597089803e-08 NA NA NA hsa-miR-186-5p TGFB2 -0.0960063082183451 0.868141302182904 -0.3344966009348 0.191883995261116 mirMAP -0.621355169758057 1.07645506474653e-09 NA NA NA hsa-miR-200a-3p TGFB2 0.321954194605755 0.636347043136301 -0.3344966009348 0.191883995261116 MirTarget;miRNATAP -0.349625252947739 2.44117272738656e-25 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 0.553445956735887 0.586179706179699 -0.3344966009348 0.191883995261116 MirTarget -0.137892151335788 5.76268091391752e-06 NA NA NA hsa-miR-29b-3p TGFB2 -0.0116608366459126 0.986707629219868 -0.3344966009348 0.191883995261116 miRTarBase;MirTarget;miRNATAP -0.231729413265765 0.0012231669483933 NA NA NA hsa-miR-29c-3p TGFB2 -0.0398599630396124 0.961734653751747 -0.3344966009348 0.191883995261116 MirTarget;miRNATAP -0.531424404132598 2.96641887384219e-13 NA NA NA hsa-miR-301a-3p TGFB2 0.0543935929126307 0.86100497502589 -0.3344966009348 0.191883995261116 MirTarget;miRNATAP -0.322704555190408 7.77034372961379e-08 NA NA NA hsa-miR-32-3p TGFB2 0.109275300940862 0.518933706765513 -0.3344966009348 0.191883995261116 mirMAP -0.27315114570865 1.69846948907938e-05 NA NA NA hsa-miR-320a TGFB2 -0.173747231083235 0.798491205195337 -0.3344966009348 0.191883995261116 miRanda -0.39585907442477 2.33018021074793e-05 NA NA NA hsa-miR-320b TGFB2 -0.0988100064360236 0.653009378717132 -0.3344966009348 0.191883995261116 miRanda -0.298228917269413 2.53643349382992e-05 NA NA NA hsa-miR-324-5p TGFB2 0.0519393001587378 0.894960490401887 -0.3344966009348 0.191883995261116 miRanda -0.302705023736643 2.71602770897574e-07 NA NA NA hsa-miR-330-3p TGFB2 0.00862581859895206 0.968643104627764 -0.3344966009348 0.191883995261116 miRNATAP -0.457254743325048 1.06037579343258e-09 NA NA NA hsa-miR-330-5p TGFB2 0.0149209812014917 0.969806885007443 -0.3344966009348 0.191883995261116 miRanda -0.360450971736555 2.54978879561545e-05 NA NA NA hsa-miR-331-5p TGFB2 -0.0485134632079254 0.787272827885559 -0.3344966009348 0.191883995261116 miRNATAP -0.239937976385475 0.00244538329219784 NA NA NA hsa-miR-335-3p TGFB2 0.248463575981435 0.607467452476391 -0.3344966009348 0.191883995261116 mirMAP -0.22185528629857 1.89547879442152e-07 NA NA NA hsa-miR-335-5p TGFB2 0.228179825634298 0.407604021226595 -0.3344966009348 0.191883995261116 miRNAWalker2_validate -0.252111592909568 1.14412319370904e-06 NA NA NA hsa-miR-33a-3p TGFB2 0.108471046357151 0.54723623490155 -0.3344966009348 0.191883995261116 MirTarget;mirMAP -0.371056624502634 8.36332661191753e-09 NA NA NA hsa-miR-361-5p TGFB2 -0.0739340134141884 0.90219495022229 -0.3344966009348 0.191883995261116 miRNATAP -0.810004741713957 2.97484706931026e-12 NA NA NA hsa-miR-362-3p TGFB2 -0.242005568209823 0.177516344352304 -0.3344966009348 0.191883995261116 miRanda -0.218398256631292 0.00107142313440827 NA NA NA hsa-miR-362-5p TGFB2 -0.0216298550571863 0.935793260481247 -0.3344966009348 0.191883995261116 MirTarget -0.222085312260446 0.000683040393757458 NA NA NA hsa-miR-374a-5p TGFB2 -0.100643000793718 0.795400800247954 -0.3344966009348 0.191883995261116 mirMAP -0.292264596541037 0.0136347038708632 NA NA NA hsa-miR-429 TGFB2 0.415614548843864 0.504839831319045 -0.3344966009348 0.191883995261116 miRNATAP -0.354478665199625 1.01610694076904e-25 NA NA NA hsa-miR-454-3p TGFB2 0.000234581340140316 0.999269071367307 -0.3344966009348 0.191883995261116 MirTarget;miRNATAP -0.36249217687122 1.13442108861214e-06 NA NA NA hsa-miR-500a-5p TGFB2 -0.0464080385816543 0.826291260520874 -0.3344966009348 0.191883995261116 mirMAP -0.230492171637341 0.0012015489418391 NA NA NA hsa-miR-500b-5p TGFB2 -0.0460400797115601 0.827713264074563 -0.3344966009348 0.191883995261116 MirTarget -0.231076703558946 0.00116359223151538 NA NA NA hsa-miR-589-3p TGFB2 -0.201968894307347 0.291443294237989 -0.3344966009348 0.191883995261116 MirTarget -0.125134916260589 0.0325888808995323 NA NA NA hsa-miR-590-3p TGFB2 -0.216104759768254 0.330588330096734 -0.3344966009348 0.191883995261116 mirMAP -0.266142801996328 0.000194961333085026 NA NA NA hsa-miR-590-5p TGFB2 -0.11748040817411 0.713387911750096 -0.3344966009348 0.191883995261116 miRanda;miRNATAP -0.324271064441974 3.01832441227307e-07 NA NA NA hsa-miR-944 TGFB2 -0.456233617420337 0.371080282344214 -0.3344966009348 0.191883995261116 mirMAP -0.180206577855112 5.25792273122866e-08 NA NA NA hsa-let-7a-5p TGFBR1 -0.0853495373838147 0.935969055203681 0.0777525056076227 0.847704270497333 TargetScan;miRNATAP -0.244428925468535 0.000440383623292106 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC colorectal cancer hsa-let-7b-5p TGFBR1 -0.0551576054511145 0.954518641843015 0.0777525056076227 0.847704270497333 miRNATAP -0.164395211205111 0.002334077702266 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7d-5p TGFBR1 0.0329922020858602 0.954344308800577 0.0777525056076227 0.847704270497333 miRNAWalker2_validate;miRNATAP -0.249677273322744 5.91436156062502e-06 NA NA NA hsa-let-7e-5p TGFBR1 0.0835602958433785 0.91388417390088 0.0777525056076227 0.847704270497333 miRNATAP -0.165779353656999 0.000445651685953496 NA NA NA hsa-let-7f-5p TGFBR1 -0.0475717241799885 0.960559611665325 0.0777525056076227 0.847704270497333 miRNATAP -0.212539435969951 0.000421071580866339 NA NA NA hsa-let-7g-5p TGFBR1 -0.0714665618891566 0.915547203795166 0.0777525056076227 0.847704270497333 miRNATAP -0.498242721643013 1.58222259474873e-18 NA NA NA hsa-miR-101-3p TGFBR1 -0.056091234765713 0.952965033672988 0.0777525056076227 0.847704270497333 miRNAWalker2_validate;miRNATAP -0.356084641759078 1.678272043475e-10 NA NA NA hsa-miR-126-5p TGFBR1 -0.124081421741405 0.812001894056048 0.0777525056076227 0.847704270497333 mirMAP;miRNATAP -0.153123735128566 0.00137633400200009 NA NA NA hsa-miR-128-3p TGFBR1 -0.122076540461818 0.814951824329629 0.0777525056076227 0.847704270497333 miRNAWalker2_validate;miRTarBase -0.248098643403413 2.90608464652714e-08 NA NA NA hsa-miR-130b-3p TGFBR1 -0.0723220500487693 0.847618325912693 0.0777525056076227 0.847704270497333 miRNATAP -0.134668437053487 3.34039315804437e-06 NA NA NA hsa-miR-16-2-3p TGFBR1 -0.116881861084735 0.660768767649374 0.0777525056076227 0.847704270497333 mirMAP -0.118014665876922 0.00216991899384218 NA NA NA hsa-miR-181c-5p TGFBR1 0.181344386779278 0.638470017100076 0.0777525056076227 0.847704270497333 mirMAP;miRNATAP -0.16918051477343 2.32913877572708e-05 NA NA NA hsa-miR-186-5p TGFBR1 -0.0960063082183451 0.868141302182904 0.0777525056076227 0.847704270497333 mirMAP -0.261901522962087 6.15270096138054e-07 NA NA NA hsa-miR-200b-3p TGFBR1 0.338618480110268 0.658564567688223 0.0777525056076227 0.847704270497333 mirMAP -0.185163040320424 3.55754064059769e-23 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-2110 TGFBR1 -0.287047175354765 0.0530318197575401 0.0777525056076227 0.847704270497333 miRNATAP -0.203122265430452 3.02839928126399e-08 NA NA NA hsa-miR-301a-3p TGFBR1 0.0543935929126307 0.86100497502589 0.0777525056076227 0.847704270497333 miRNATAP -0.188558650494062 6.94428278524489e-10 NA NA NA hsa-miR-32-3p TGFBR1 0.109275300940862 0.518933706765513 0.0777525056076227 0.847704270497333 mirMAP;miRNATAP -0.116207615183923 0.000365699800115398 NA NA NA hsa-miR-3200-3p TGFBR1 0.0357661258344302 0.895977160131688 0.0777525056076227 0.847704270497333 miRNATAP -0.120700105473579 2.69621919466987e-08 NA NA NA hsa-miR-320a TGFBR1 -0.173747231083235 0.798491205195337 0.0777525056076227 0.847704270497333 PITA;miRanda;miRNATAP -0.326176915517583 4.1064210958607e-12 NA NA NA hsa-miR-320b TGFBR1 -0.0988100064360236 0.653009378717132 0.0777525056076227 0.847704270497333 PITA;miRanda;miRNATAP -0.191128801910238 1.11537638054288e-07 NA NA NA hsa-miR-330-3p TGFBR1 0.00862581859895206 0.968643104627764 0.0777525056076227 0.847704270497333 mirMAP;miRNATAP -0.231238826647919 1.69019842696319e-09 NA NA NA hsa-miR-331-3p TGFBR1 -0.0536903745546304 0.876535860398392 0.0777525056076227 0.847704270497333 PITA;miRNATAP -0.227588969955072 5.92157067223612e-10 NA NA NA hsa-miR-361-5p TGFBR1 -0.0739340134141884 0.90219495022229 0.0777525056076227 0.847704270497333 miRanda;mirMAP;miRNATAP -0.327512599032841 4.9385335452745e-08 NA NA NA hsa-miR-374a-5p TGFBR1 -0.100643000793718 0.795400800247954 0.0777525056076227 0.847704270497333 mirMAP -0.1725550403971 0.00437986725180039 NA NA NA hsa-miR-429 TGFBR1 0.415614548843864 0.504839831319045 0.0777525056076227 0.847704270497333 miRanda;miRNATAP -0.169764852224625 2.30995613689702e-22 NA NA NA hsa-miR-454-3p TGFBR1 0.000234581340140316 0.999269071367307 0.0777525056076227 0.847704270497333 mirMAP;miRNATAP -0.205677505304361 6.16209314820036e-08 NA NA NA hsa-miR-500a-5p TGFBR1 -0.0464080385816543 0.826291260520874 0.0777525056076227 0.847704270497333 mirMAP -0.111391945877042 0.0022402772038843 NA NA NA hsa-miR-576-5p TGFBR1 -0.154721087610302 0.57104937618374 0.0777525056076227 0.847704270497333 mirMAP -0.201284779052 2.74992936654638e-07 NA NA NA hsa-miR-589-3p TGFBR1 -0.201968894307347 0.291443294237989 0.0777525056076227 0.847704270497333 mirMAP -0.104859492543737 0.000438540974273448 NA NA NA hsa-miR-590-3p TGFBR1 -0.216104759768254 0.330588330096734 0.0777525056076227 0.847704270497333 PITA;miRanda;mirMAP;miRNATAP -0.139228339501584 0.000139021577037225 NA NA NA hsa-miR-590-5p TGFBR1 -0.11748040817411 0.713387911750096 0.0777525056076227 0.847704270497333 PITA;miRanda -0.158386241001983 1.04882834086946e-06 NA NA NA hsa-miR-664a-3p TGFBR1 0.0401159915820761 0.916604143060055 0.0777525056076227 0.847704270497333 mirMAP -0.321621318973717 1.70943055444078e-13 NA NA NA hsa-miR-769-5p TGFBR1 0.0112760703556383 0.973990378702921 0.0777525056076227 0.847704270497333 PITA;miRNATAP -0.228524293799953 9.85398652877069e-09 NA NA NA hsa-miR-944 TGFBR1 -0.456233617420337 0.371080282344214 0.0777525056076227 0.847704270497333 PITA;mirMAP -0.104949150832685 4.75355134217921e-10 NA NA NA hsa-miR-96-5p TGFBR1 0.253659022880497 0.519928436451318 0.0777525056076227 0.847704270497333 TargetScan;miRNATAP -0.138876787398621 7.90055950171446e-10 NA NA NA hsa-miR-98-5p TGFBR1 -0.0187922337001103 0.967726266866676 0.0777525056076227 0.847704270497333 miRNAWalker2_validate -0.401926180925558 8.43130029155261e-16 NA NA NA hsa-let-7b-5p TGFBR3 -0.0551576054511145 0.954518641843015 0.347224164589446 0.428255225726825 MirTarget -0.353571778463802 0.000737905769843802 NA NA NA hsa-let-7i-5p TGFBR3 -0.0169192323549616 0.97808096325159 0.347224164589446 0.428255225726825 MirTarget -0.694609854826207 1.28284665233358e-07 NA NA NA hsa-miR-15a-5p TGFBR3 -0.149822297617648 0.791626259098658 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.334666618812116 2.4364757552723e-05 NA NA NA hsa-miR-15b-5p TGFBR3 -0.0634307049035439 0.913894456387502 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.358067034321255 4.08959861418962e-05 NA NA NA hsa-miR-16-2-3p TGFBR3 -0.116881861084735 0.660768767649374 0.347224164589446 0.428255225726825 mirMAP -0.544752570527393 6.96637221131045e-14 NA NA NA hsa-miR-16-5p TGFBR3 -0.14946137381698 0.821005492953259 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.535995055796637 1.19037291949918e-09 NA NA NA hsa-miR-181a-5p TGFBR3 -0.0952743147701067 0.89803512431227 0.347224164589446 0.428255225726825 miRNAWalker2_validate;mirMAP;miRNATAP -0.533327553140963 2.53974355292015e-12 NA NA NA hsa-miR-181b-5p TGFBR3 -0.164743110284032 0.784712839384427 0.347224164589446 0.428255225726825 mirMAP -0.432103104420789 2.3616864237891e-10 NA NA NA hsa-miR-181c-5p TGFBR3 0.181344386779278 0.638470017100076 0.347224164589446 0.428255225726825 mirMAP;miRNATAP -0.172396736027208 0.0276183859643452 NA NA NA hsa-miR-185-3p TGFBR3 -0.0826066698146857 0.717992081600081 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.178532534746358 0.0036751676836322 NA NA NA hsa-miR-186-5p TGFBR3 -0.0960063082183451 0.868141302182904 0.347224164589446 0.428255225726825 MirTarget -0.432866677091555 2.38094635988513e-05 NA NA NA hsa-miR-18a-3p TGFBR3 -0.316631209375323 0.123775439738554 0.347224164589446 0.428255225726825 MirTarget -0.384745830428724 3.20279500560706e-13 NA NA NA hsa-miR-18a-5p TGFBR3 -0.12244806406876 0.740985232636778 0.347224164589446 0.428255225726825 MirTarget -0.408782150301723 1.32531260268041e-14 NA NA NA hsa-miR-193a-3p TGFBR3 -0.00832669565946897 0.972913473583695 0.347224164589446 0.428255225726825 MirTarget;miRanda;miRNATAP -0.404117628316179 3.34660410567723e-11 NA NA NA hsa-miR-193b-3p TGFBR3 0.108723972555656 0.824741667706356 0.347224164589446 0.428255225726825 miRNAWalker2_validate;MirTarget;miRNATAP -0.54263409776695 1.06348017136205e-18 NA NA NA hsa-miR-21-5p TGFBR3 -0.0664480432382106 0.95890230763113 0.347224164589446 0.428255225726825 miRNAWalker2_validate -0.873696976080408 1.42070935389156e-24 NA NA NA hsa-miR-222-5p TGFBR3 -0.0651347043606711 0.777571027302083 0.347224164589446 0.428255225726825 MirTarget -0.637586491113155 8.70674708946357e-31 NA NA NA hsa-miR-223-3p TGFBR3 -0.258937896799599 0.653796021408309 0.347224164589446 0.428255225726825 MirTarget -0.357942230234306 8.65290396410165e-15 NA NA NA hsa-miR-23a-3p TGFBR3 -0.0581091921468975 0.944784720219057 0.347224164589446 0.428255225726825 MirTarget;mirMAP -0.922565153945025 1.07662734633214e-18 NA NA NA hsa-miR-27a-3p TGFBR3 -0.104977891356196 0.893055025744808 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.856547795782396 8.50152722903816e-28 NA NA NA hsa-miR-29a-5p TGFBR3 0.00398947876802147 0.984362270755887 0.347224164589446 0.428255225726825 mirMAP -0.680050674340825 1.4093844780056e-23 NA NA NA hsa-miR-32-3p TGFBR3 0.109275300940862 0.518933706765513 0.347224164589446 0.428255225726825 mirMAP -0.147442607471617 0.0204519778455496 NA NA NA hsa-miR-338-3p TGFBR3 -0.207072603155625 0.729900444872807 0.347224164589446 0.428255225726825 miRanda -0.32591907256696 2.15757294303162e-07 NA NA NA hsa-miR-339-5p TGFBR3 -0.11823888001895 0.781648678404656 0.347224164589446 0.428255225726825 miRanda -0.261061195001236 5.31993152374657e-06 NA NA NA hsa-miR-340-5p TGFBR3 -0.17403079020184 0.522128842082138 0.347224164589446 0.428255225726825 mirMAP -0.300070644061892 0.00119354677245125 NA NA NA hsa-miR-34c-5p TGFBR3 -0.296356384394638 0.240599245560279 0.347224164589446 0.428255225726825 miRanda;miRNATAP -0.277892023741616 1.74141696542429e-07 NA NA NA hsa-miR-3607-3p TGFBR3 0.00708543650532656 0.982275296685967 0.347224164589446 0.428255225726825 mirMAP -0.209035995525523 0.000133096015392737 NA NA NA hsa-miR-361-3p TGFBR3 -0.093032114291506 0.857238519672262 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.605594317686423 2.29492169573009e-08 NA NA NA hsa-miR-409-3p TGFBR3 -0.0411546919308972 0.891689517093319 0.347224164589446 0.428255225726825 mirMAP -0.19586487016773 0.00536284050179962 NA NA NA hsa-miR-424-5p TGFBR3 -0.122430180216639 0.798152477902775 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.453498113768427 1.3903796591463e-09 NA NA NA hsa-miR-450b-5p TGFBR3 -0.092442822969625 0.746771401439922 0.347224164589446 0.428255225726825 mirMAP -0.164643823275733 0.024373231426323 NA NA NA hsa-miR-455-5p TGFBR3 -0.369377335730383 0.320032016262245 0.347224164589446 0.428255225726825 miRanda -0.595169359534449 1.29501226263914e-23 NA NA NA hsa-miR-484 TGFBR3 -0.00958284493971551 0.983372195324836 0.347224164589446 0.428255225726825 MirTarget;miRNATAP -0.285353013064365 0.000636411287742009 NA NA NA hsa-miR-589-3p TGFBR3 -0.201968894307347 0.291443294237989 0.347224164589446 0.428255225726825 MirTarget -0.350435514214757 8.24412223410027e-10 NA NA NA hsa-miR-590-3p TGFBR3 -0.216104759768254 0.330588330096734 0.347224164589446 0.428255225726825 MirTarget;miRanda;mirMAP -0.471663498128764 1.30242745091055e-11 NA NA NA hsa-miR-590-5p TGFBR3 -0.11748040817411 0.713387911750096 0.347224164589446 0.428255225726825 miRanda -0.399800495757582 1.45902129417123e-10 NA NA NA hsa-miR-625-5p TGFBR3 -0.194644245145882 0.222860323509099 0.347224164589446 0.428255225726825 MirTarget -0.303726876266838 1.96419820901604e-05 NA NA NA hsa-miR-627-5p TGFBR3 -0.0450638227185949 0.77357863045219 0.347224164589446 0.428255225726825 MirTarget -0.302068567741635 1.24234557528916e-05 NA NA NA hsa-miR-7-1-3p TGFBR3 -0.132725495142008 0.67412515459916 0.347224164589446 0.428255225726825 mirMAP -0.481191222243271 1.84156222707957e-10 NA NA NA hsa-miR-320a WNT11 -0.173747231083235 0.798491205195337 -0.122847988116888 0.692528485803131 miRanda -0.419932472809252 0.00246805866460523 NA NA NA hsa-miR-330-3p WNT11 0.00862581859895206 0.968643104627764 -0.122847988116888 0.692528485803131 miRNATAP -0.630031523186883 1.32892882444745e-08 NA NA NA hsa-miR-429 WNT11 0.415614548843864 0.504839831319045 -0.122847988116888 0.692528485803131 miRNATAP -0.323236245003944 4.91620754160683e-10 NA NA NA