miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-5p ACTG1 -1.62016148171663 1.56547487335694e-15 0.210452998709538 0.0807508226224021 miRNAWalker2_validate -0.104633304361218 7.1938332344753e-05 NA NA NA hsa-miR-148a-5p ACTG1 1.45633512586855 1.81792463521257e-08 0.210452998709538 0.0807508226224021 MirTarget;miRNATAP -0.110855417746644 1.05382508287165e-07 NA NA NA hsa-miR-186-5p ACTG1 0.852175445703945 6.88885738584309e-10 0.210452998709538 0.0807508226224021 MirTarget -0.132693808353617 0.000853094147511062 NA NA NA hsa-miR-190a-5p ACTG1 -1.73469282765072 9.35431238569038e-09 0.210452998709538 0.0807508226224021 MirTarget -0.104544287577666 2.58409819150229e-06 NA NA NA hsa-miR-652-3p ACTG1 -0.671627949773221 0.000567715420294627 0.210452998709538 0.0807508226224021 miRNAWalker2_validate -0.119289092238562 2.40518461693115e-05 NA NA NA hsa-miR-21-3p AMOT 2.54206008030157 1.11598785398763e-30 -0.302410252155047 0.45042622184089 mirMAP -0.217597325207037 0.00545793637715579 NA NA NA hsa-miR-212-3p AMOT 0.404496907089793 0.103551762277891 -0.302410252155047 0.45042622184089 MirTarget -0.268541569946238 0.000292461032390067 NA NA NA hsa-miR-2355-3p AMOT 1.10676344164715 6.24068383465151e-06 -0.302410252155047 0.45042622184089 MirTarget;miRNATAP -0.254289183453493 0.0012488959610372 NA NA NA hsa-miR-320b AMOT 0.226640952564488 0.378818692487242 -0.302410252155047 0.45042622184089 miRanda -0.208757449275356 0.00362556093140242 NA NA NA hsa-miR-330-5p AMOT 0.168520831101569 0.336433937906706 -0.302410252155047 0.45042622184089 miRanda -0.49921569241639 2.11652260670485e-06 NA NA NA hsa-miR-335-3p AMOT 1.51116383169018 6.88553098788624e-13 -0.302410252155047 0.45042622184089 mirMAP -0.364830685166053 1.87901138907175e-05 NA NA NA hsa-miR-576-5p AMOT 1.02693643167056 1.14846964470173e-06 -0.302410252155047 0.45042622184089 mirMAP -0.304586629326874 0.000430722743806974 NA NA NA hsa-miR-625-5p AMOT 1.38208523187596 6.28473801440755e-07 -0.302410252155047 0.45042622184089 MirTarget -0.219930357496532 0.00278273846833265 NA NA NA hsa-miR-629-3p AMOT 1.31892116211001 0.000114487182853678 -0.302410252155047 0.45042622184089 MirTarget -0.304912254496927 1.16455542680746e-07 NA NA NA hsa-miR-106b-5p APC 1.47447672652218 1.32004094930462e-13 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate;miRTarBase -0.160151734491997 2.27862007699814e-07 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-142-3p APC 3.98476449801341 1.56256182021111e-35 -0.81362334855622 2.34409310508842e-09 MirTarget;PITA;miRanda;miRNATAP -0.129581416245212 5.1300823863087e-13 NA NA NA hsa-miR-182-5p APC 3.21839823004635 5.13049145201115e-39 -0.81362334855622 2.34409310508842e-09 MirTarget -0.121845418493389 2.17323154862301e-07 NA NA NA hsa-miR-186-5p APC 0.852175445703945 6.88885738584309e-10 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate -0.232136880640038 3.271825543298e-07 NA NA NA hsa-miR-193a-3p APC 0.549173467360291 0.0319030569365466 -0.81362334855622 2.34409310508842e-09 miRanda -0.120903071477339 6.68461456828318e-06 NA NA NA hsa-miR-21-5p APC 4.38165933891779 1.52536633902505e-92 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate -0.144937162471473 1.26897892677296e-09 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-210-3p APC 4.89285936864822 4.81769290932762e-28 -0.81362334855622 2.34409310508842e-09 miRNAWalker2_validate -0.110530227622043 1.49305331878995e-17 NA NA NA hsa-miR-450b-5p APC 1.69248953402469 1.96052058003353e-07 -0.81362334855622 2.34409310508842e-09 miRNATAP -0.131524767664808 6.18647514096151e-10 NA NA NA hsa-miR-589-3p APC 1.34253876396688 1.84935927493927e-05 -0.81362334855622 2.34409310508842e-09 MirTarget -0.107516350519092 1.76806883201475e-07 NA NA NA hsa-miR-590-3p APC 0.83851360565783 0.00129224433453587 -0.81362334855622 2.34409310508842e-09 PITA;miRanda;mirMAP;miRNATAP -0.206678927804611 4.70677024968128e-13 NA NA NA hsa-miR-7-1-3p APC 2.61364240402652 1.98959237815786e-32 -0.81362334855622 2.34409310508842e-09 MirTarget -0.110663740061812 9.37432693363158e-05 NA NA NA hsa-let-7a-5p APC2 -1.37014061604018 3.11451492971224e-14 1.13734300868111 0.000124925970306742 TargetScan -0.464919515060219 2.14185938273543e-10 NA NA NA hsa-miR-2110 APC2 -1.92124860612475 1.1464887721828e-12 1.13734300868111 0.000124925970306742 MirTarget;miRNATAP -0.179829115815386 0.000321446020349742 NA NA NA hsa-miR-221-5p APC2 -2.2173523967387 1.8954728277084e-09 1.13734300868111 0.000124925970306742 mirMAP -0.100180944873868 0.00794329184829682 NA NA NA hsa-miR-664a-5p APC2 -0.0936480603578111 0.662274905077117 1.13734300868111 0.000124925970306742 mirMAP -0.184305709745507 0.00537252679600084 NA NA NA hsa-miR-107 AREG 0.658676029898313 5.11480446318819e-07 -0.86211359649712 0.0952206389154785 miRanda -0.530492988772643 0.00362095452848057 NA NA NA hsa-miR-326 AREG -0.992397386750901 0.00335173765975096 -0.86211359649712 0.0952206389154785 miRanda -0.268748266879567 0.000119314431697342 NA NA NA hsa-miR-330-5p AREG 0.168520831101569 0.336433937906706 -0.86211359649712 0.0952206389154785 miRanda -0.405900222683146 0.00303456583082398 NA NA NA hsa-miR-429 AREG 2.3794516574089 1.72813419703734e-13 -0.86211359649712 0.0952206389154785 miRanda -0.325650117645307 2.592073703752e-05 NA NA NA hsa-miR-335-5p AXIN1 -0.466533891325811 0.0676987038122831 0.529388216277775 2.72687033050374e-05 miRNAWalker2_validate -0.118760864503714 3.03238519983658e-06 NA NA NA hsa-miR-15a-5p AXIN2 1.62575353599172 1.55312121019827e-19 -1.4952232670323 9.5322330602006e-08 MirTarget;miRNATAP -0.217041543063005 0.00198973394153194 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-221-3p AXIN2 -0.0986794612964683 0.654454148658401 -1.4952232670323 9.5322330602006e-08 miRNATAP -0.192459747047839 0.00122885278253862 NA NA NA hsa-miR-222-3p AXIN2 0.0327210697409583 0.881937768109611 -1.4952232670323 9.5322330602006e-08 miRNATAP -0.248218141503819 2.9034801887089e-05 NA NA NA hsa-miR-424-5p AXIN2 1.26485330287919 6.1498991028257e-06 -1.4952232670323 9.5322330602006e-08 MirTarget;miRNATAP -0.197607378372592 1.81497593184144e-05 NA NA NA hsa-miR-590-3p AXIN2 0.83851360565783 0.00129224433453587 -1.4952232670323 9.5322330602006e-08 MirTarget;PITA;miRanda;miRNATAP -0.263625743981492 1.01810938870619e-05 NA NA NA hsa-miR-143-3p BBC3 -1.21021691908494 5.70938667332876e-06 0.729914396380796 0.000240595565409828 miRNATAP -0.259215465787601 6.42589215480081e-15 NA NA NA hsa-miR-423-5p BBC3 -1.80309342242719 1.34791344187441e-19 0.729914396380796 0.000240595565409828 PITA -0.188981076908296 1.9768046193777e-05 NA NA NA hsa-miR-500a-5p BIRC2 0.648155655714409 0.0104657432932038 -0.0566424270372563 0.620255875001944 MirTarget -0.112472951411246 8.53911662639019e-08 NA NA NA hsa-let-7b-5p BIRC5 -1.62016148171663 1.56547487335694e-15 3.51383700584189 3.08956001691714e-21 miRNAWalker2_validate -0.793486427196937 3.51583437685013e-22 NA NA NA hsa-miR-101-3p BIRC5 1.38889039459232 1.96522549511542e-09 3.51383700584189 3.08956001691714e-21 miRNAWalker2_validate -0.312135820064188 3.8814536922077e-05 NA NA NA hsa-miR-218-5p BIRC5 -0.281408491748349 0.259553612322657 3.51383700584189 3.08956001691714e-21 miRTarBase;MirTarget -0.523376863367214 3.89613394859806e-13 25473903;25900794;26442524 Survivin BIRC5 was subsequently identified as an important cervical cancer target of miR-218 using in silico prediction mRNA profiling and quantitative real-time PCR qRT-PCR;miR-218 binds survivin BIRC5 mRNA 3'-UTR and down-regulated reporter luciferase activity;MiR-218 promoted apoptosis inhibited cell proliferation and caused cell cycle arrest in CRC cells by suppressing BIRC5 expression; In conclusion we demonstrated that high miR-218 expression had a positive prognostic value in 5-FU-based treatments for CRC patients and discovered a novel mechanism mediated by miR-218 to promote apoptosis and to function synergistically with 5-FU to promote chemosensitivity by suppressing BIRC5 and TS in CRC ;; cervical and endocervical cancer;breast cancer;colorectal cancer hsa-miR-30c-5p BIRC5 -0.327319105755825 0.123595832152687 3.51383700584189 3.08956001691714e-21 miRNAWalker2_validate -0.650338465663217 2.52955155953809e-15 NA NA NA hsa-miR-338-3p BIRC5 0.726843067232002 0.0506251324215494 3.51383700584189 3.08956001691714e-21 miRanda -0.26084508496133 4.00309123916091e-08 NA NA NA hsa-miR-34c-5p BIRC5 -1.00125440032112 0.0724432896090357 3.51383700584189 3.08956001691714e-21 miRanda -0.209548601239342 2.77202545269952e-10 NA NA NA hsa-miR-375 BIRC5 0.615547997686534 0.149199273675144 3.51383700584189 3.08956001691714e-21 miRanda -0.129502981273597 0.00197812266121585 NA NA NA hsa-miR-106a-5p BMP2 1.3902608059488 6.07931522284525e-05 -2.20218138996674 4.40922299691684e-10 miRNATAP -0.249678598494913 2.10782040436559e-06 NA NA NA hsa-miR-106b-5p BMP2 1.47447672652218 1.32004094930462e-13 -2.20218138996674 4.40922299691684e-10 miRNATAP -0.321171575371965 7.38282859737633e-05 NA NA NA hsa-miR-142-5p BMP2 1.29672439149353 4.0768822158894e-06 -2.20218138996674 4.40922299691684e-10 PITA;miRNATAP -0.185868077906383 0.00332715123738121 NA NA NA hsa-miR-17-5p BMP2 2.07078488653279 2.77403038572568e-19 -2.20218138996674 4.40922299691684e-10 TargetScan -0.279404908743065 4.93554924874424e-05 NA NA NA hsa-miR-20a-5p BMP2 2.64649625616975 5.1469418982085e-27 -2.20218138996674 4.40922299691684e-10 miRNATAP -0.244304289249649 0.000117211326364688 NA NA NA hsa-miR-335-3p BMP2 1.51116383169018 6.88553098788624e-13 -2.20218138996674 4.40922299691684e-10 mirMAP -0.262142813909157 0.000654246945535322 NA NA NA hsa-miR-421 BMP2 0.170525317701774 0.535277026680289 -2.20218138996674 4.40922299691684e-10 PITA;miRanda -0.256560714760867 8.6645740573278e-05 NA NA NA hsa-miR-590-3p BMP2 0.83851360565783 0.00129224433453587 -2.20218138996674 4.40922299691684e-10 PITA;miRanda;mirMAP -0.308279377806258 4.75756433012178e-05 NA NA NA hsa-miR-590-3p BMP4 0.83851360565783 0.00129224433453587 -0.738953241326025 0.0363951146733439 miRanda -0.248039365467682 0.000895117633758315 NA NA NA hsa-miR-576-5p BMP5 1.02693643167056 1.14846964470173e-06 -1.82049308810788 0.000192198267616928 mirMAP -0.40261061210729 0.000147007077753807 NA NA NA hsa-miR-301a-3p BMP6 2.70198002906399 1.56420889710984e-14 -1.88264470042502 1.40105688602636e-05 MirTarget -0.196437013528704 0.00438221631769075 NA NA NA hsa-miR-34c-5p BMP6 -1.00125440032112 0.0724432896090357 -1.88264470042502 1.40105688602636e-05 miRanda -0.134471918829295 0.000385967285533583 NA NA NA hsa-miR-590-5p BMP6 2.07441240363458 4.95240551694843e-14 -1.88264470042502 1.40105688602636e-05 miRanda -0.265137691527235 0.00269283144308233 NA NA NA hsa-miR-106b-5p BMP7 1.47447672652218 1.32004094930462e-13 -1.00047861355404 0.0554601667387613 mirMAP -0.447391020197377 0.000146158130647344 NA NA NA hsa-miR-130b-5p BMP7 1.53645187062942 1.10498816261505e-08 -1.00047861355404 0.0554601667387613 mirMAP -0.431434796104066 8.12236868694198e-07 NA NA NA hsa-miR-17-5p BMP7 2.07078488653279 2.77403038572568e-19 -1.00047861355404 0.0554601667387613 mirMAP -0.322736919312449 0.00129929063725447 NA NA NA hsa-miR-30a-3p BMP8A -2.54042202792785 2.9111625410859e-18 2.2515613801065 1.33854720615621e-13 MirTarget -0.444528509969284 1.21990566015851e-22 NA NA NA hsa-miR-30b-3p BMP8A -1.20976737190106 2.63726511331003e-06 2.2515613801065 1.33854720615621e-13 MirTarget -0.209764776063547 0.000148309472317191 NA NA NA hsa-miR-30e-3p BMP8A -0.104420043859122 0.526240453209293 2.2515613801065 1.33854720615621e-13 MirTarget -0.463195939427945 1.15234967525317e-07 NA NA NA hsa-miR-423-5p BMP8A -1.80309342242719 1.34791344187441e-19 2.2515613801065 1.33854720615621e-13 MirTarget -0.34388591620231 6.4263098553594e-07 NA NA NA hsa-miR-150-5p BMP8B -0.702328520623782 0.0215316651134431 0.985281852560022 3.18387827311083e-05 mirMAP -0.113893357330359 0.00149723556624448 NA NA NA hsa-miR-26b-5p BMP8B 0.72362441215247 4.7794659748036e-05 0.985281852560022 3.18387827311083e-05 miRNAWalker2_validate -0.162467142480102 0.00853999505656764 NA NA NA hsa-miR-423-5p BMP8B -1.80309342242719 1.34791344187441e-19 0.985281852560022 3.18387827311083e-05 MirTarget -0.138907753037157 0.00905638735856723 NA NA NA hsa-miR-452-3p BMP8B 0.477736876273128 0.22218404598603 0.985281852560022 3.18387827311083e-05 mirMAP -0.102334724856014 0.00171594082029197 NA NA NA hsa-miR-140-5p BMPR1A 0.669142684153918 0.000335928403032308 -0.513987967595526 1.4949236428874e-05 miRanda -0.114813825031728 0.000139151173457615 NA NA NA hsa-miR-142-5p BMPR1A 1.29672439149353 4.0768822158894e-06 -0.513987967595526 1.4949236428874e-05 MirTarget -0.111373359604046 8.06941339090764e-08 NA NA NA hsa-miR-186-5p BMPR1A 0.852175445703945 6.88885738584309e-10 -0.513987967595526 1.4949236428874e-05 MirTarget -0.146091696206645 0.00021436571569852 NA NA NA hsa-miR-146b-5p BMPR1B 1.0922867893808 5.63754607494775e-06 -1.00870930794828 0.0221223226813232 miRanda -0.324386131682726 0.000104180169025598 NA NA NA hsa-miR-375 BMPR1B 0.615547997686534 0.149199273675144 -1.00870930794828 0.0221223226813232 miRNATAP -0.197376151838817 3.05523761658226e-05 NA NA NA hsa-miR-106a-5p BMPR2 1.3902608059488 6.07931522284525e-05 -1.24575126318081 8.97625514457859e-23 MirTarget;miRNATAP -0.126621444122879 4.37796334992821e-11 NA NA NA hsa-miR-106b-5p BMPR2 1.47447672652218 1.32004094930462e-13 -1.24575126318081 8.97625514457859e-23 MirTarget;miRNATAP -0.170053448073806 9.50152173122071e-09 NA NA NA hsa-miR-128-3p BMPR2 1.03509868349735 2.11606310588315e-10 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate -0.157508935197664 2.00509727335241e-05 NA NA NA hsa-miR-130b-3p BMPR2 1.83046548750752 5.04753914574694e-13 -1.24575126318081 8.97625514457859e-23 MirTarget;miRNATAP -0.159740346639267 5.6918698753661e-11 NA NA NA hsa-miR-143-5p BMPR2 1.86670676070774 1.06290100545251e-09 -1.24575126318081 8.97625514457859e-23 mirMAP -0.115573038972702 2.26826870212743e-09 NA NA NA hsa-miR-148a-3p BMPR2 2.30885799126944 1.95226081368985e-21 -1.24575126318081 8.97625514457859e-23 mirMAP -0.16342996848784 4.32464015303451e-12 NA NA NA hsa-miR-148b-3p BMPR2 0.483970528590224 0.0026495409465901 -1.24575126318081 8.97625514457859e-23 mirMAP -0.220576088710011 4.90437073945797e-09 NA NA NA hsa-miR-16-2-3p BMPR2 0.503964803530872 0.0263648405197492 -1.24575126318081 8.97625514457859e-23 mirMAP -0.132068148003201 5.77953190882814e-06 NA NA NA hsa-miR-17-5p BMPR2 2.07078488653279 2.77403038572568e-19 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.253922915381524 8.76769072371774e-26 NA NA NA hsa-miR-182-5p BMPR2 3.21839823004635 5.13049145201115e-39 -1.24575126318081 8.97625514457859e-23 mirMAP -0.14867677421271 3.01710867779005e-11 NA NA NA hsa-miR-185-5p BMPR2 1.14291034858482 2.95777119743491e-13 -1.24575126318081 8.97625514457859e-23 MirTarget -0.212000988776395 2.28922577044379e-08 NA NA NA hsa-miR-186-5p BMPR2 0.852175445703945 6.88885738584309e-10 -1.24575126318081 8.97625514457859e-23 mirMAP -0.330092270997084 1.42972564484141e-14 NA NA NA hsa-miR-19a-3p BMPR2 2.11776595911517 7.07663078397156e-10 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;MirTarget;miRNATAP -0.187510998919191 7.8245900156268e-21 NA NA NA hsa-miR-19b-3p BMPR2 2.10868505662119 5.40846613768389e-17 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;MirTarget;miRNATAP -0.187415577703082 7.28129026682454e-15 NA NA NA hsa-miR-20a-5p BMPR2 2.64649625616975 5.1469418982085e-27 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.234440967693608 6.00713765770744e-26 NA NA NA hsa-miR-21-5p BMPR2 4.38165933891779 1.52536633902505e-92 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;miRTarBase;MirTarget -0.196763625666812 1.90921418194688e-18 NA NA NA hsa-miR-25-3p BMPR2 0.361927330834176 0.0163670566170988 -1.24575126318081 8.97625514457859e-23 miRNATAP -0.169823567630548 3.12423193797212e-05 NA NA NA hsa-miR-26a-2-3p BMPR2 0.264287787772609 0.305653616292982 -1.24575126318081 8.97625514457859e-23 mirMAP -0.104500210619639 0.000412369813301713 NA NA NA hsa-miR-26b-5p BMPR2 0.72362441215247 4.7794659748036e-05 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate -0.159119661159762 3.09813821209868e-06 NA NA NA hsa-miR-29a-5p BMPR2 1.89519956688438 1.03453349363915e-11 -1.24575126318081 8.97625514457859e-23 mirMAP -0.214152284625404 6.0094819796293e-18 NA NA NA hsa-miR-301a-3p BMPR2 2.70198002906399 1.56420889710984e-14 -1.24575126318081 8.97625514457859e-23 MirTarget;miRNATAP -0.185569311515388 2.68406406703708e-20 NA NA NA hsa-miR-30c-5p BMPR2 -0.327319105755825 0.123595832152687 -1.24575126318081 8.97625514457859e-23 mirMAP -0.100318637495242 0.000502252948600578 NA NA NA hsa-miR-30e-5p BMPR2 1.60414100786743 3.78951090573667e-19 -1.24575126318081 8.97625514457859e-23 mirMAP -0.188604922673538 6.59949871456668e-09 NA NA NA hsa-miR-32-5p BMPR2 0.876853679269853 6.04859399018691e-05 -1.24575126318081 8.97625514457859e-23 miRNATAP -0.102883622524095 0.000661672771441845 NA NA NA hsa-miR-335-3p BMPR2 1.51116383169018 6.88553098788624e-13 -1.24575126318081 8.97625514457859e-23 mirMAP -0.167416897496565 2.31244339307128e-09 NA NA NA hsa-miR-33a-5p BMPR2 2.80127809675219 5.09053890529424e-12 -1.24575126318081 8.97625514457859e-23 mirMAP -0.154934294519925 1.21633926866421e-18 NA NA NA hsa-miR-342-3p BMPR2 -0.128691966564961 0.561034080130801 -1.24575126318081 8.97625514457859e-23 PITA;miRanda;miRNATAP -0.141535193547544 2.60808530013085e-07 NA NA NA hsa-miR-429 BMPR2 2.3794516574089 1.72813419703734e-13 -1.24575126318081 8.97625514457859e-23 mirMAP;miRNATAP -0.104331521043792 1.33074797165655e-07 NA NA NA hsa-miR-450b-5p BMPR2 1.69248953402469 1.96052058003353e-07 -1.24575126318081 8.97625514457859e-23 MirTarget;mirMAP -0.109641529657781 9.2642119027409e-08 NA NA NA hsa-miR-454-3p BMPR2 1.49453641052169 4.46235742871434e-09 -1.24575126318081 8.97625514457859e-23 MirTarget;miRNATAP -0.262144271848387 3.47155768146394e-22 NA NA NA hsa-miR-532-5p BMPR2 0.576620898517708 0.0023245812680956 -1.24575126318081 8.97625514457859e-23 PITA -0.16851079278378 1.45360324033884e-07 NA NA NA hsa-miR-590-3p BMPR2 0.83851360565783 0.00129224433453587 -1.24575126318081 8.97625514457859e-23 MirTarget;miRanda;mirMAP;miRNATAP -0.182817477339754 3.3124155642635e-11 NA NA NA hsa-miR-590-5p BMPR2 2.07441240363458 4.95240551694843e-14 -1.24575126318081 8.97625514457859e-23 MirTarget;PITA;miRNATAP -0.258029466948522 5.64918998790027e-24 NA NA NA hsa-miR-628-5p BMPR2 1.06173574237323 4.67541261016756e-06 -1.24575126318081 8.97625514457859e-23 MirTarget;PITA;miRNATAP -0.133362112745277 1.93632263712615e-05 NA NA NA hsa-miR-629-5p BMPR2 1.31657090341737 1.45711558652127e-12 -1.24575126318081 8.97625514457859e-23 mirMAP -0.134288381199812 2.8794806425862e-05 NA NA NA hsa-miR-651-5p BMPR2 1.67013048675395 1.61458229225137e-07 -1.24575126318081 8.97625514457859e-23 MirTarget -0.165809959139643 6.72821791434081e-13 NA NA NA hsa-miR-671-5p BMPR2 2.24156654191798 2.10433241567652e-14 -1.24575126318081 8.97625514457859e-23 miRNATAP -0.231427549401149 1.22948149186361e-23 NA NA NA hsa-miR-7-1-3p BMPR2 2.61364240402652 1.98959237815786e-32 -1.24575126318081 8.97625514457859e-23 mirMAP -0.214414256495984 5.91430518323011e-16 NA NA NA hsa-miR-92a-3p BMPR2 -0.136362762339122 0.493412263619364 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;miRNATAP -0.1351544026853 1.09006913258693e-05 NA NA NA hsa-miR-93-3p BMPR2 1.07631808403007 1.63747525692813e-05 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate -0.189023582880744 1.2014304275913e-15 NA NA NA hsa-miR-93-5p BMPR2 1.50844106515467 1.83836866996875e-12 -1.24575126318081 8.97625514457859e-23 miRNAWalker2_validate;MirTarget;miRNATAP -0.304098929242688 3.4258152133419e-31 NA NA NA hsa-miR-96-5p BMPR2 3.0381097138467 4.40362891630201e-24 -1.24575126318081 8.97625514457859e-23 mirMAP -0.216052633600134 2.87978275706375e-24 NA NA NA hsa-miR-103a-3p BTRC 0.538497806383155 1.88134691850591e-05 0.0480417791180399 0.622827696093888 MirTarget;miRNATAP -0.113248753589541 0.00155888979006598 NA NA NA hsa-miR-16-5p BTRC 0.749619098384047 4.11649450706988e-06 0.0480417791180399 0.622827696093888 miRNAWalker2_validate;MirTarget;miRNATAP -0.107405552913543 8.38188422898451e-05 NA NA NA hsa-miR-342-3p BTRC -0.128691966564961 0.561034080130801 0.0480417791180399 0.622827696093888 mirMAP -0.136089179349028 6.98648472032989e-12 NA NA NA hsa-miR-106a-5p CCND1 1.3902608059488 6.07931522284525e-05 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.247441760563832 4.58943715400631e-11 NA NA NA hsa-miR-106b-5p CCND1 1.47447672652218 1.32004094930462e-13 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.261384817974007 7.4979419817232e-06 NA NA NA hsa-miR-142-3p CCND1 3.98476449801341 1.56256182021111e-35 -0.295767629587253 0.255400743295204 miRanda -0.119299030581201 0.000532277158339159 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-15a-5p CCND1 1.62575353599172 1.55312121019827e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.199069637483131 0.0019294787514794 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 -1.25935038177398 1.83460220856901e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.303824360423629 3.25741318048184e-06 NA NA NA hsa-miR-16-1-3p CCND1 1.50034693398929 6.63958242991125e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.249107447749185 3.23141967346606e-05 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.749619098384047 4.11649450706988e-06 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.371885624299403 3.21606546730418e-07 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 2.07078488653279 2.77403038572568e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.313758634258834 1.59321495552009e-10 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 0.852175445703945 6.88885738584309e-10 -0.295767629587253 0.255400743295204 mirMAP -0.377477028673122 1.06268066352005e-05 NA NA NA hsa-miR-193a-3p CCND1 0.549173467360291 0.0319030569365466 -0.295767629587253 0.255400743295204 MirTarget;PITA;miRanda -0.190950932146342 0.000161171890671323 NA NA NA hsa-miR-193b-3p CCND1 1.10444771306846 0.000822888533401377 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget -0.147999411883792 3.70620495015026e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-19a-3p CCND1 2.11776595911517 7.07663078397156e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;miRNATAP -0.21539529985992 9.86203433305448e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 1.71217036351784 3.28561659177495e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.301713494105536 2.89182846291565e-08 NA NA NA hsa-miR-19b-3p CCND1 2.10868505662119 5.40846613768389e-17 -0.295767629587253 0.255400743295204 miRNATAP -0.179773518063806 0.000197856717032667 NA NA NA hsa-miR-20a-5p CCND1 2.64649625616975 5.1469418982085e-27 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.237160136465301 1.84669386058676e-07 NA NA NA hsa-miR-20b-5p CCND1 1.35770573270947 0.00260808530013016 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.179107595068828 5.65966117118738e-11 NA NA NA hsa-miR-365a-3p CCND1 0.0132777124336201 0.953597412537431 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.193166924738263 0.000234492957903034 NA NA NA hsa-miR-374a-5p CCND1 -0.197027254874826 0.298080902192861 -0.295767629587253 0.255400743295204 MirTarget -0.313785702713176 9.54081268797886e-06 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 0.474691035780475 0.0109217471394203 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget -0.26116225100222 0.00011561978488339 NA NA NA hsa-miR-425-5p CCND1 1.21659524959201 8.01126418494715e-09 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.245575402525843 1.03844251357893e-05 NA NA NA hsa-miR-589-3p CCND1 1.34253876396688 1.84935927493927e-05 -0.295767629587253 0.255400743295204 MirTarget -0.130907472589194 0.000793150025378685 NA NA NA hsa-miR-590-3p CCND1 0.83851360565783 0.00129224433453587 -0.295767629587253 0.255400743295204 mirMAP -0.182941292569374 0.000856336828554768 NA NA NA hsa-miR-769-3p CCND1 0.452126659761753 0.0748150639143322 -0.295767629587253 0.255400743295204 mirMAP -0.142316943866129 0.00276805281261241 NA NA NA hsa-miR-92a-3p CCND1 -0.136362762339122 0.493412263619364 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.337251172229938 1.62058605849004e-08 NA NA NA hsa-miR-93-5p CCND1 1.50844106515467 1.83836866996875e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;miRNATAP -0.320397820083252 2.84014735439528e-09 NA NA NA hsa-miR-942-5p CCND1 -0.0372813055050076 0.870631058767894 -0.295767629587253 0.255400743295204 MirTarget -0.177314558661089 0.000979800060419363 NA NA NA hsa-miR-106a-5p CCND2 1.3902608059488 6.07931522284525e-05 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.149132151233025 1.88464236882735e-05 NA NA NA hsa-miR-106b-5p CCND2 1.47447672652218 1.32004094930462e-13 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383655587509124 2.65429916887189e-13 NA NA NA hsa-miR-130b-5p CCND2 1.53645187062942 1.10498816261505e-08 -1.64140990579885 1.49666938681079e-12 mirMAP -0.268032769997331 9.22343432530747e-12 NA NA NA hsa-miR-141-3p CCND2 3.36993755486106 5.42939251147195e-32 -1.64140990579885 1.49666938681079e-12 MirTarget;TargetScan -0.239914655059016 6.4654039095017e-12 NA NA NA hsa-miR-151a-3p CCND2 0.665271883054405 0.000281673348137154 -1.64140990579885 1.49666938681079e-12 mirMAP -0.279142680983949 2.60564778780149e-06 NA NA NA hsa-miR-15a-5p CCND2 1.62575353599172 1.55312121019827e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158338209854594 0.00711668272045409 NA NA NA hsa-miR-17-5p CCND2 2.07078488653279 2.77403038572568e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.365048259055278 1.61934056872758e-16 NA NA NA hsa-miR-182-5p CCND2 3.21839823004635 5.13049145201115e-39 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.373145719566719 1.32597677460149e-21 NA NA NA hsa-miR-183-5p CCND2 2.39247234736657 3.92444525331999e-21 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.410520271082553 1.11291256348519e-25 NA NA NA hsa-miR-185-5p CCND2 1.14291034858482 2.95777119743491e-13 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.23940712387784 0.000484175543966546 NA NA NA hsa-miR-186-5p CCND2 0.852175445703945 6.88885738584309e-10 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.357370184588874 5.14493635358813e-06 NA NA NA hsa-miR-191-5p CCND2 0.343645878547116 0.0668114086143391 -1.64140990579885 1.49666938681079e-12 MirTarget -0.19767765908675 0.000750401585158583 NA NA NA hsa-miR-19a-3p CCND2 2.11776595911517 7.07663078397156e-10 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.167455065978335 6.56621464464812e-06 NA NA NA hsa-miR-19b-3p CCND2 2.10868505662119 5.40846613768389e-17 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.19157786848984 1.39328108679414e-05 NA NA NA hsa-miR-200a-3p CCND2 3.14766878548496 1.32850889777422e-21 -1.64140990579885 1.49666938681079e-12 MirTarget -0.173744823500602 6.53232158053391e-08 NA NA NA hsa-miR-20a-5p CCND2 2.64649625616975 5.1469418982085e-27 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.28367508352758 5.6750334332974e-12 NA NA NA hsa-miR-21-3p CCND2 2.54206008030157 1.11598785398763e-30 -1.64140990579885 1.49666938681079e-12 mirMAP -0.212907340098529 4.00646631535515e-06 NA NA NA hsa-miR-2355-3p CCND2 1.10676344164715 6.24068383465151e-06 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.221166273655799 1.96123873319489e-06 NA NA NA hsa-miR-28-5p CCND2 1.19639196514745 4.59365801666536e-18 -1.64140990579885 1.49666938681079e-12 miRanda -0.289410618824274 0.00017592467355866 NA NA NA hsa-miR-301a-3p CCND2 2.70198002906399 1.56420889710984e-14 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.265639128307335 3.9945374923581e-13 NA NA NA hsa-miR-320b CCND2 0.226640952564488 0.378818692487242 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.123605256651271 0.00373003525561283 NA NA NA hsa-miR-324-3p CCND2 -0.0774700133118458 0.689226297032231 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.276159423764137 9.9462768745637e-07 NA NA NA hsa-miR-331-5p CCND2 0.578237334664505 0.00131211239210882 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.275952758002927 9.36107182529594e-06 NA NA NA hsa-miR-429 CCND2 2.3794516574089 1.72813419703734e-13 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.209322906628109 2.95963655497587e-09 NA NA NA hsa-miR-450b-5p CCND2 1.69248953402469 1.96052058003353e-07 -1.64140990579885 1.49666938681079e-12 MirTarget;PITA;miRNATAP -0.145422700655101 8.53356735526403e-05 NA NA NA hsa-miR-501-5p CCND2 0.411357595674671 0.10435288464149 -1.64140990579885 1.49666938681079e-12 PITA;mirMAP;miRNATAP -0.144149908130612 0.000856140982438327 NA NA NA hsa-miR-503-5p CCND2 1.97129438815516 2.1704434283035e-09 -1.64140990579885 1.49666938681079e-12 MirTarget -0.132569636435255 4.69239346000773e-05 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 0.59977150019756 0.0314775340172755 -1.64140990579885 1.49666938681079e-12 MirTarget -0.220699899618513 1.33146855439522e-08 NA NA NA hsa-miR-589-3p CCND2 1.34253876396688 1.84935927493927e-05 -1.64140990579885 1.49666938681079e-12 mirMAP -0.194613807523332 3.68596504229146e-08 NA NA NA hsa-miR-590-3p CCND2 0.83851360565783 0.00129224433453587 -1.64140990579885 1.49666938681079e-12 miRanda;mirMAP -0.133052154455084 0.00820830741469702 NA NA NA hsa-miR-590-5p CCND2 2.07441240363458 4.95240551694843e-14 -1.64140990579885 1.49666938681079e-12 mirMAP -0.258740782004531 5.16823341358779e-08 NA NA NA hsa-miR-660-5p CCND2 2.04875198906126 1.08269480928897e-17 -1.64140990579885 1.49666938681079e-12 mirMAP -0.145565210932688 0.00131443056428649 NA NA NA hsa-miR-7-1-3p CCND2 2.61364240402652 1.98959237815786e-32 -1.64140990579885 1.49666938681079e-12 mirMAP -0.259792711431322 7.83559584811719e-08 NA NA NA hsa-miR-877-5p CCND2 -0.370234513208225 0.20670834111988 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.150269749089241 5.7135351515868e-05 NA NA NA hsa-miR-93-5p CCND2 1.50844106515467 1.83836866996875e-12 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.414585687663892 1.04746846150745e-17 NA NA NA hsa-miR-96-5p CCND2 3.0381097138467 4.40362891630201e-24 -1.64140990579885 1.49666938681079e-12 TargetScan;miRNATAP -0.357833634781266 1.13611538125112e-20 NA NA NA hsa-miR-320b CCND3 0.226640952564488 0.378818692487242 -0.858556164090156 9.93688486289821e-06 miRanda -0.106740567141186 0.00235090988932412 NA NA NA hsa-miR-421 CCND3 0.170525317701774 0.535277026680289 -0.858556164090156 9.93688486289821e-06 PITA;miRanda -0.120402813664522 0.000730915299268324 NA NA NA hsa-miR-96-5p CCND3 3.0381097138467 4.40362891630201e-24 -0.858556164090156 9.93688486289821e-06 TargetScan -0.12470872406597 0.000146574618288945 NA NA NA hsa-miR-139-5p CDH1 -2.26625553116965 7.22375119369519e-16 0.870348290057859 2.89775093534096e-05 PITA;miRanda -0.151604982165671 4.47085880511407e-06 NA NA NA hsa-miR-186-5p CDH1 0.852175445703945 6.88885738584309e-10 0.870348290057859 2.89775093534096e-05 mirMAP -0.209494239089859 0.00259152667382002 NA NA NA hsa-miR-342-3p CDH1 -0.128691966564961 0.561034080130801 0.870348290057859 2.89775093534096e-05 miRanda -0.209229145716445 1.47599293163427e-06 NA NA NA hsa-miR-92a-3p CDH1 -0.136362762339122 0.493412263619364 0.870348290057859 2.89775093534096e-05 miRTarBase -0.189280117442659 9.86510829704474e-05 25515201;21148309 The expression of miR-92a PTEN and E-cadherin was analyzed by real-time PCR; No any association of miR-92a and E-cadherin was found p = 0.128;We further demonstrated that miR-92a directly targeted the CDH1 3'-UTR and repressed the expression of CDH1 a tumor metastasis suppressor; In addition restoring of miR-92a-resistant CDH1 expression in miR-92a-overexpression cells recovered the pro-metastasis activity of miR-92a; Taken together we demonstrated that miR-92a promotes ESCC cell migration and invasion at least partially via suppression of CDH1 expression and patients with up-regulated miR-92a are prone to lymph node metastasis and thus have poor prognosis ;metastasis;worse prognosis;cell migration colorectal cancer;esophageal cancer hsa-let-7b-5p CSNK1D -1.62016148171663 1.56547487335694e-15 0.257255116997011 0.00411809722892917 miRNAWalker2_validate -0.108726182496662 2.20489450964981e-08 NA NA NA hsa-miR-140-3p CSNK1D -1.11373309124537 8.35257079443689e-14 0.257255116997011 0.00411809722892917 MirTarget -0.144670939735368 6.72483595183469e-08 NA NA NA hsa-miR-30a-3p CSNK1E -2.54042202792785 2.9111625410859e-18 0.278381360256052 0.0363387376050516 miRNATAP -0.101232623060726 4.11541018280741e-07 NA NA NA hsa-miR-16-2-3p CTGF 0.503964803530872 0.0263648405197492 -1.93919990217197 1.23139457575587e-12 MirTarget -0.19323825832132 0.00175521750530604 NA NA NA hsa-miR-18a-5p CTGF 1.37435209536521 9.2173853686829e-06 -1.93919990217197 1.23139457575587e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.212240225387845 1.7430616244331e-06 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling poor survival glioblastoma hsa-miR-19a-3p CTGF 2.11776595911517 7.07663078397156e-10 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.251352682939966 7.22225795499269e-09 NA NA NA hsa-miR-19b-3p CTGF 2.10868505662119 5.40846613768389e-17 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.330005606313434 1.25796573303135e-10 NA NA NA hsa-miR-26b-3p CTGF 1.37388760789373 8.32526977075803e-09 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.160488447596543 0.00260563510076072 25761878 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1 sarcoma hsa-miR-3065-5p CTGF 0.653308707552535 0.0999497219778851 -1.93919990217197 1.23139457575587e-12 MirTarget;miRNATAP -0.168583438955929 1.46806495242491e-06 NA NA NA hsa-miR-590-3p CTGF 0.83851360565783 0.00129224433453587 -1.93919990217197 1.23139457575587e-12 PITA;miRanda -0.1889416678022 0.00140691509980854 NA NA NA hsa-miR-7-1-3p CTGF 2.61364240402652 1.98959237815786e-32 -1.93919990217197 1.23139457575587e-12 MirTarget -0.334460512582212 3.85772558267046e-09 NA NA NA hsa-miR-155-5p CTNNA1 0.813513839059142 0.000608282725633232 -0.215480492337587 0.0675805120649184 miRNAWalker2_validate -0.129529458727627 7.7441608750107e-09 NA NA NA hsa-miR-421 CTNNA1 0.170525317701774 0.535277026680289 -0.215480492337587 0.0675805120649184 miRanda -0.101221630065624 1.90089973428846e-06 NA NA NA hsa-miR-590-3p CTNNA1 0.83851360565783 0.00129224433453587 -0.215480492337587 0.0675805120649184 miRanda -0.112629202368486 5.02887223510187e-06 NA NA NA hsa-miR-532-3p CTNNB1 -0.677758187385834 0.0147557885796065 -0.0107290862071228 0.94149303042168 miRNAWalker2_validate -0.10624268556781 9.19755717985264e-06 NA NA NA hsa-miR-106a-5p DLG2 1.3902608059488 6.07931522284525e-05 -0.403736778868201 0.152291752542734 mirMAP -0.137439135233611 0.000924636814703932 NA NA NA hsa-miR-1301-3p DLG2 0.845987603184611 0.000579808501723616 -0.403736778868201 0.152291752542734 MirTarget -0.171410052765006 0.00111447767714134 NA NA NA hsa-miR-148b-3p DLG2 0.483970528590224 0.0026495409465901 -0.403736778868201 0.152291752542734 miRNAWalker2_validate;MirTarget -0.486085152385225 1.18328767344282e-09 NA NA NA hsa-miR-148b-5p DLG2 1.39335695292409 2.13220380550073e-07 -0.403736778868201 0.152291752542734 mirMAP -0.201526213361167 0.000431581783151998 NA NA NA hsa-miR-15b-3p DLG2 0.804736041893915 0.000400279611457186 -0.403736778868201 0.152291752542734 mirMAP -0.27420520417484 4.35086785667994e-06 NA NA NA hsa-miR-16-2-3p DLG2 0.503964803530872 0.0263648405197492 -0.403736778868201 0.152291752542734 mirMAP -0.221982866933245 0.000349535903632552 NA NA NA hsa-miR-17-5p DLG2 2.07078488653279 2.77403038572568e-19 -0.403736778868201 0.152291752542734 mirMAP -0.265396197699675 7.71569852763795e-07 NA NA NA hsa-miR-182-5p DLG2 3.21839823004635 5.13049145201115e-39 -0.403736778868201 0.152291752542734 miRNATAP -0.146608390649817 0.00244231793467733 NA NA NA hsa-miR-186-5p DLG2 0.852175445703945 6.88885738584309e-10 -0.403736778868201 0.152291752542734 mirMAP -0.325336759597734 0.00049328743811573 NA NA NA hsa-miR-19a-3p DLG2 2.11776595911517 7.07663078397156e-10 -0.403736778868201 0.152291752542734 mirMAP -0.16659592134801 0.000163314685326988 NA NA NA hsa-miR-19b-3p DLG2 2.10868505662119 5.40846613768389e-17 -0.403736778868201 0.152291752542734 mirMAP -0.187638222402182 0.000346553273981423 NA NA NA hsa-miR-20a-5p DLG2 2.64649625616975 5.1469418982085e-27 -0.403736778868201 0.152291752542734 mirMAP -0.206082283411195 3.2761840949798e-05 NA NA NA hsa-miR-25-3p DLG2 0.361927330834176 0.0163670566170988 -0.403736778868201 0.152291752542734 mirMAP -0.304944969864698 0.000442698565751712 NA NA NA hsa-miR-29a-3p DLG2 0.101650412194573 0.573201097011668 -0.403736778868201 0.152291752542734 MirTarget;miRNATAP -0.197450455155407 0.00651957607402476 NA NA NA hsa-miR-29b-1-5p DLG2 1.71024742617744 3.64915691793611e-09 -0.403736778868201 0.152291752542734 mirMAP -0.195853540050316 7.6299735885302e-06 NA NA NA hsa-miR-29b-3p DLG2 3.10527711861309 3.01242507282711e-32 -0.403736778868201 0.152291752542734 MirTarget;miRNATAP -0.132225766567858 0.0041082709884319 NA NA NA hsa-miR-30d-3p DLG2 0.00396376345349925 0.986457040013182 -0.403736778868201 0.152291752542734 MirTarget;miRNATAP -0.163317762532352 0.00911371386498754 NA NA NA hsa-miR-32-5p DLG2 0.876853679269853 6.04859399018691e-05 -0.403736778868201 0.152291752542734 mirMAP -0.266892155283138 2.99183246824639e-05 NA NA NA hsa-miR-335-3p DLG2 1.51116383169018 6.88553098788624e-13 -0.403736778868201 0.152291752542734 mirMAP -0.212494364358699 0.000418183972016872 NA NA NA hsa-miR-335-5p DLG2 -0.466533891325811 0.0676987038122831 -0.403736778868201 0.152291752542734 miRNAWalker2_validate -0.159763593863391 0.00506092847275518 NA NA NA hsa-miR-33a-5p DLG2 2.80127809675219 5.09053890529424e-12 -0.403736778868201 0.152291752542734 mirMAP -0.102940186836712 0.00786993828455133 NA NA NA hsa-miR-429 DLG2 2.3794516574089 1.72813419703734e-13 -0.403736778868201 0.152291752542734 miRNATAP -0.151618416392217 0.000340541147683756 NA NA NA hsa-miR-576-5p DLG2 1.02693643167056 1.14846964470173e-06 -0.403736778868201 0.152291752542734 PITA;mirMAP -0.219570706665194 0.000311639861314735 NA NA NA hsa-miR-582-5p DLG2 1.08286181406653 0.00149040450161757 -0.403736778868201 0.152291752542734 PITA -0.100476283979112 0.00984102393721724 NA NA NA hsa-miR-590-3p DLG2 0.83851360565783 0.00129224433453587 -0.403736778868201 0.152291752542734 PITA;miRanda;mirMAP -0.235058869744501 7.58420771059921e-05 NA NA NA hsa-miR-590-5p DLG2 2.07441240363458 4.95240551694843e-14 -0.403736778868201 0.152291752542734 PITA;miRanda -0.256310261876651 5.96170546775652e-06 NA NA NA hsa-miR-7-1-3p DLG2 2.61364240402652 1.98959237815786e-32 -0.403736778868201 0.152291752542734 MirTarget -0.18376014458276 0.00151184579253475 NA NA NA hsa-miR-92a-3p DLG2 -0.136362762339122 0.493412263619364 -0.403736778868201 0.152291752542734 mirMAP -0.242234498016648 0.000213367170403481 NA NA NA hsa-miR-93-3p DLG2 1.07631808403007 1.63747525692813e-05 -0.403736778868201 0.152291752542734 MirTarget;miRNATAP -0.143847366305866 0.00534735764158123 NA NA NA hsa-miR-342-3p DLG3 -0.128691966564961 0.561034080130801 0.712459977109487 4.5349528492059e-08 miRanda -0.10308835913002 0.000172932699614609 NA NA NA hsa-miR-107 DLG4 0.658676029898313 5.11480446318819e-07 -0.821273230625516 1.01721040684995e-05 PITA;miRanda;miRNATAP -0.332702970681918 3.8396179236483e-07 NA NA NA hsa-miR-10a-5p DVL1 0.790595816051606 0.000593731378445468 0.537116741650716 0.00278581195143785 miRNAWalker2_validate -0.189413502532476 9.88413912627841e-08 NA NA NA hsa-miR-378a-3p DVL1 -2.0140903990983 1.146745431034e-18 0.537116741650716 0.00278581195143785 miRNAWalker2_validate -0.149505366560106 1.73014077594512e-05 NA NA NA hsa-miR-221-3p DVL2 -0.0986794612964683 0.654454148658401 0.153977175010176 0.173455299106473 miRNAWalker2_validate -0.151498096790727 6.50854487638767e-11 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-27a-3p DVL2 0.433402568013802 0.00737164631768323 0.153977175010176 0.173455299106473 miRNATAP -0.131356980312861 4.36386056136407e-05 NA NA NA hsa-miR-27b-3p DVL2 0.236438984240408 0.12263510345883 0.153977175010176 0.173455299106473 miRNATAP -0.110422616929709 0.00124237687721228 NA NA NA hsa-let-7a-5p DVL3 -1.37014061604018 3.11451492971224e-14 0.469598709675249 5.08889848281915e-05 TargetScan -0.196140360872535 5.12757954456713e-12 NA NA NA hsa-miR-26b-5p DVL3 0.72362441215247 4.7794659748036e-05 0.469598709675249 5.08889848281915e-05 miRNAWalker2_validate -0.105711667021789 0.000428610590238721 NA NA NA hsa-miR-30a-3p DVL3 -2.54042202792785 2.9111625410859e-18 0.469598709675249 5.08889848281915e-05 MirTarget -0.112956661058372 7.70147345102754e-11 NA NA NA hsa-miR-30d-3p DVL3 0.00396376345349925 0.986457040013182 0.469598709675249 5.08889848281915e-05 MirTarget -0.102036980859097 7.20837596129398e-05 NA NA NA hsa-miR-30e-3p DVL3 -0.104420043859122 0.526240453209293 0.469598709675249 5.08889848281915e-05 MirTarget -0.133644394662235 4.34952118264702e-05 NA NA NA hsa-miR-106b-5p FBXW11 1.47447672652218 1.32004094930462e-13 -0.304254731329676 0.0102183490252362 miRNATAP -0.126298023858063 1.9170408960343e-06 NA NA NA hsa-miR-130b-3p FBXW11 1.83046548750752 5.04753914574694e-13 -0.304254731329676 0.0102183490252362 MirTarget -0.122718315806876 1.91282443061689e-08 NA NA NA hsa-miR-148b-3p FBXW11 0.483970528590224 0.0026495409465901 -0.304254731329676 0.0102183490252362 miRNAWalker2_validate -0.103348505983789 0.00237906115080139 NA NA NA hsa-miR-17-5p FBXW11 2.07078488653279 2.77403038572568e-19 -0.304254731329676 0.0102183490252362 TargetScan;miRNATAP -0.167027938373327 4.52313762859858e-14 NA NA NA hsa-miR-186-5p FBXW11 0.852175445703945 6.88885738584309e-10 -0.304254731329676 0.0102183490252362 mirMAP -0.175750885983245 6.55467779816094e-06 NA NA NA hsa-miR-19a-3p FBXW11 2.11776595911517 7.07663078397156e-10 -0.304254731329676 0.0102183490252362 MirTarget -0.143452154166452 1.98044424581938e-15 NA NA NA hsa-miR-19b-3p FBXW11 2.10868505662119 5.40846613768389e-17 -0.304254731329676 0.0102183490252362 MirTarget -0.119924843906287 3.73194704106557e-08 NA NA NA hsa-miR-20a-5p FBXW11 2.64649625616975 5.1469418982085e-27 -0.304254731329676 0.0102183490252362 miRNATAP -0.143416317717865 2.39931189775028e-12 NA NA NA hsa-miR-454-3p FBXW11 1.49453641052169 4.46235742871434e-09 -0.304254731329676 0.0102183490252362 MirTarget -0.169952238371185 5.80951107599515e-12 NA NA NA hsa-miR-590-3p FBXW11 0.83851360565783 0.00129224433453587 -0.304254731329676 0.0102183490252362 mirMAP -0.149942542187609 1.14712601574015e-09 NA NA NA hsa-miR-93-5p FBXW11 1.50844106515467 1.83836866996875e-12 -0.304254731329676 0.0102183490252362 miRNATAP -0.176311222713498 4.21086569405097e-13 NA NA NA hsa-miR-942-5p FBXW11 -0.0372813055050076 0.870631058767894 -0.304254731329676 0.0102183490252362 MirTarget -0.158672486621794 4.2670769473323e-11 NA NA NA hsa-miR-96-5p FBXW11 3.0381097138467 4.40362891630201e-24 -0.304254731329676 0.0102183490252362 MirTarget;TargetScan;miRNATAP -0.106705593230835 5.80920933501703e-08 NA NA NA hsa-miR-16-1-3p FGF1 1.50034693398929 6.63958242991125e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.264990724395016 0.000104336880288483 NA NA NA hsa-miR-186-5p FGF1 0.852175445703945 6.88885738584309e-10 -0.577676136313124 0.0506048044371249 mirMAP -0.468236590634635 1.51395461317672e-06 NA NA NA hsa-miR-18a-5p FGF1 1.37435209536521 9.2173853686829e-06 -0.577676136313124 0.0506048044371249 MirTarget -0.313741396264592 1.24482978490312e-11 NA NA NA hsa-miR-320b FGF1 0.226640952564488 0.378818692487242 -0.577676136313124 0.0506048044371249 miRanda -0.145122007313635 0.00620299731128628 NA NA NA hsa-miR-330-5p FGF1 0.168520831101569 0.336433937906706 -0.577676136313124 0.0506048044371249 miRanda;miRNATAP -0.396337147508732 3.26538084155222e-07 NA NA NA hsa-miR-429 FGF1 2.3794516574089 1.72813419703734e-13 -0.577676136313124 0.0506048044371249 miRNATAP -0.116223459446297 0.00906049231323183 NA NA NA hsa-miR-576-5p FGF1 1.02693643167056 1.14846964470173e-06 -0.577676136313124 0.0506048044371249 PITA;mirMAP -0.353451864713746 2.30476528411685e-08 NA NA NA hsa-miR-590-5p FGF1 2.07441240363458 4.95240551694843e-14 -0.577676136313124 0.0506048044371249 MirTarget;miRanda;miRNATAP -0.188750550916759 0.00157081419432906 NA NA NA hsa-miR-629-5p FGF1 1.31657090341737 1.45711558652127e-12 -0.577676136313124 0.0506048044371249 MirTarget -0.255543406785593 0.000362449168272974 NA NA NA hsa-miR-7-5p FGF1 0.343825848926135 0.435063427976906 -0.577676136313124 0.0506048044371249 miRNAWalker2_validate -0.167943341210869 1.20539892015732e-05 NA NA NA hsa-miR-106a-5p FRMD6 1.3902608059488 6.07931522284525e-05 0.0341499757997852 0.901411488941117 MirTarget;miRNATAP -0.11300085708634 0.00535672472664226 NA NA NA hsa-miR-106b-5p FRMD6 1.47447672652218 1.32004094930462e-13 0.0341499757997852 0.901411488941117 MirTarget;miRNATAP -0.211664359100112 0.000654086430528172 NA NA NA hsa-miR-141-3p FRMD6 3.36993755486106 5.42939251147195e-32 0.0341499757997852 0.901411488941117 MirTarget;TargetScan;miRNATAP -0.290093800846408 6.35989974323033e-13 NA NA NA hsa-miR-16-2-3p FRMD6 0.503964803530872 0.0263648405197492 0.0341499757997852 0.901411488941117 mirMAP -0.206866285334331 0.000647868840322636 NA NA NA hsa-miR-17-5p FRMD6 2.07078488653279 2.77403038572568e-19 0.0341499757997852 0.901411488941117 MirTarget;TargetScan;miRNATAP -0.230916867580441 1.12002339084068e-05 NA NA NA hsa-miR-200a-3p FRMD6 3.14766878548496 1.32850889777422e-21 0.0341499757997852 0.901411488941117 MirTarget;miRNATAP -0.233541327154605 2.78710771803528e-10 NA NA NA hsa-miR-200b-3p FRMD6 1.55157578247391 4.83790020897188e-09 0.0341499757997852 0.901411488941117 TargetScan -0.265326667132803 1.12657440171093e-08 NA NA NA hsa-miR-200c-3p FRMD6 0.380533388300368 0.0842181838538353 0.0341499757997852 0.901411488941117 miRNATAP -0.398215351887021 1.72436657624791e-12 NA NA NA hsa-miR-20a-5p FRMD6 2.64649625616975 5.1469418982085e-27 0.0341499757997852 0.901411488941117 MirTarget;miRNATAP -0.213750625936434 9.97519165852218e-06 NA NA NA hsa-miR-29b-2-5p FRMD6 0.345881055247341 0.194842633194187 0.0341499757997852 0.901411488941117 MirTarget -0.216561523371262 4.59803287031191e-06 NA NA NA hsa-miR-301a-3p FRMD6 2.70198002906399 1.56420889710984e-14 0.0341499757997852 0.901411488941117 MirTarget -0.145160204516957 0.000805230111196637 NA NA NA hsa-miR-30b-5p FRMD6 0.358144314839612 0.138026229059594 0.0341499757997852 0.901411488941117 MirTarget -0.337270552490935 6.67204237950195e-11 NA NA NA hsa-miR-30c-5p FRMD6 -0.327319105755825 0.123595832152687 0.0341499757997852 0.901411488941117 MirTarget;miRNATAP -0.274552004782508 3.88301916214688e-06 NA NA NA hsa-miR-30d-5p FRMD6 -0.920901858717441 3.50898334321668e-05 0.0341499757997852 0.901411488941117 MirTarget;miRNATAP -0.370301059609026 2.77984160337335e-11 NA NA NA hsa-miR-30e-5p FRMD6 1.60414100786743 3.78951090573667e-19 0.0341499757997852 0.901411488941117 MirTarget -0.196277194094339 0.00405602821563492 NA NA NA hsa-miR-335-3p FRMD6 1.51116383169018 6.88553098788624e-13 0.0341499757997852 0.901411488941117 mirMAP -0.23568445363465 5.91521972359346e-05 NA NA NA hsa-miR-3613-5p FRMD6 0.0237159233591191 0.934730899070298 0.0341499757997852 0.901411488941117 miRNATAP -0.162490628070919 0.00195171645271138 NA NA NA hsa-miR-362-3p FRMD6 0.194097672030785 0.52808475179225 0.0341499757997852 0.901411488941117 miRanda;miRNATAP -0.213468065094144 3.23032732447912e-05 NA NA NA hsa-miR-375 FRMD6 0.615547997686534 0.149199273675144 0.0341499757997852 0.901411488941117 miRanda -0.26975230893735 2.12158085876638e-21 NA NA NA hsa-miR-429 FRMD6 2.3794516574089 1.72813419703734e-13 0.0341499757997852 0.901411488941117 miRanda;miRNATAP -0.209184796363946 3.43442659218026e-07 NA NA NA hsa-miR-454-3p FRMD6 1.49453641052169 4.46235742871434e-09 0.0341499757997852 0.901411488941117 MirTarget -0.294464164673675 4.07751760939301e-07 NA NA NA hsa-miR-501-5p FRMD6 0.411357595674671 0.10435288464149 0.0341499757997852 0.901411488941117 MirTarget;PITA;miRNATAP -0.261241416044257 1.39269468913043e-07 NA NA NA hsa-miR-93-5p FRMD6 1.50844106515467 1.83836866996875e-12 0.0341499757997852 0.901411488941117 MirTarget;miRNATAP -0.2016885903088 0.000489225798926272 NA NA NA hsa-miR-148b-5p FZD1 1.39335695292409 2.13220380550073e-07 -0.364780801849827 0.099789866871212 MirTarget -0.238991392112307 8.35167122011463e-08 NA NA NA hsa-miR-186-5p FZD1 0.852175445703945 6.88885738584309e-10 -0.364780801849827 0.099789866871212 mirMAP -0.332559523219329 5.26187654799382e-06 NA NA NA hsa-miR-192-5p FZD1 2.03412119423736 1.6357945826287e-05 -0.364780801849827 0.099789866871212 miRNAWalker2_validate -0.134725053543569 1.43082682392726e-10 NA NA NA hsa-miR-215-5p FZD1 0.116505586532384 0.8384722675454 -0.364780801849827 0.099789866871212 miRNAWalker2_validate -0.126505888779909 4.3842973814988e-10 NA NA NA hsa-miR-29b-3p FZD1 3.10527711861309 3.01242507282711e-32 -0.364780801849827 0.099789866871212 mirMAP -0.125446746266628 0.000515999817396821 NA NA NA hsa-miR-590-3p FZD1 0.83851360565783 0.00129224433453587 -0.364780801849827 0.099789866871212 miRanda -0.281562569488381 1.0442149250625e-09 NA NA NA hsa-let-7b-3p FZD3 -1.81889978084306 6.9913416210266e-19 0.792931453624831 0.000876919876092158 MirTarget;miRNATAP -0.184263488630064 0.000370143171579705 NA NA NA hsa-miR-139-5p FZD3 -2.26625553116965 7.22375119369519e-16 0.792931453624831 0.000876919876092158 PITA;miRanda -0.182797349433905 1.21442125223431e-06 NA NA NA hsa-miR-146a-5p FZD3 0.684701497250824 0.0105316554224149 0.792931453624831 0.000876919876092158 MirTarget -0.252145897493699 1.30661327817041e-09 NA NA NA hsa-miR-146b-5p FZD3 1.0922867893808 5.63754607494775e-06 0.792931453624831 0.000876919876092158 MirTarget;miRanda -0.28376896499448 2.15744686260845e-10 NA NA NA hsa-miR-155-5p FZD3 0.813513839059142 0.000608282725633232 0.792931453624831 0.000876919876092158 mirMAP -0.25323142773147 3.14655446022872e-08 NA NA NA hsa-miR-16-1-3p FZD3 1.50034693398929 6.63958242991125e-10 0.792931453624831 0.000876919876092158 mirMAP -0.150111062531523 0.00682825760263687 NA NA NA hsa-miR-181a-5p FZD3 -0.375429731222937 0.0562142867129802 0.792931453624831 0.000876919876092158 mirMAP -0.283840803685511 3.60722875994079e-07 NA NA NA hsa-miR-181b-5p FZD3 0.668793269169928 0.000239998092406404 0.792931453624831 0.000876919876092158 mirMAP -0.204834760757476 0.000705023554890027 NA NA NA hsa-miR-195-3p FZD3 -1.33068822339418 6.65427393047357e-09 0.792931453624831 0.000876919876092158 mirMAP -0.219580538095868 3.263591395444e-06 NA NA NA hsa-miR-197-3p FZD3 -1.2979654860824 1.79649132641813e-07 0.792931453624831 0.000876919876092158 MirTarget -0.144882143155394 0.000927101347232451 NA NA NA hsa-miR-199a-5p FZD3 1.3057193856884 2.38429382751645e-08 0.792931453624831 0.000876919876092158 miRanda -0.131239488498703 0.00478414336244651 NA NA NA hsa-miR-23a-3p FZD3 0.111958289789488 0.393086414480463 0.792931453624831 0.000876919876092158 MirTarget -0.347104426876378 4.62727121014698e-05 NA NA NA hsa-miR-27a-3p FZD3 0.433402568013802 0.00737164631768323 0.792931453624831 0.000876919876092158 miRNATAP -0.206725703152599 0.00257984967214742 NA NA NA hsa-miR-28-3p FZD3 0.387144500601444 0.00777919765254534 0.792931453624831 0.000876919876092158 mirMAP -0.219519505791961 0.00413988794328123 NA NA NA hsa-miR-29a-5p FZD3 1.89519956688438 1.03453349363915e-11 0.792931453624831 0.000876919876092158 mirMAP -0.142497038330642 0.0020659140986233 NA NA NA hsa-miR-30a-3p FZD3 -2.54042202792785 2.9111625410859e-18 0.792931453624831 0.000876919876092158 mirMAP -0.168028482901559 3.29027671651236e-06 NA NA NA hsa-miR-30a-5p FZD3 -0.924084264430689 0.000762030454634728 0.792931453624831 0.000876919876092158 MirTarget;miRNATAP -0.205215429689742 2.17849168944962e-07 NA NA NA hsa-miR-30c-5p FZD3 -0.327319105755825 0.123595832152687 0.792931453624831 0.000876919876092158 MirTarget;miRNATAP -0.231892280936853 7.34583171020351e-06 NA NA NA hsa-miR-30e-3p FZD3 -0.104420043859122 0.526240453209293 0.792931453624831 0.000876919876092158 mirMAP -0.198022417413322 0.00338144912718026 NA NA NA hsa-miR-342-3p FZD3 -0.128691966564961 0.561034080130801 0.792931453624831 0.000876919876092158 miRanda -0.187582992310138 0.000167550892750097 NA NA NA hsa-miR-361-5p FZD3 0.21454431962475 0.0800957579368424 0.792931453624831 0.000876919876092158 miRanda;miRNATAP -0.342058727896923 0.000182482143740012 NA NA NA hsa-miR-452-3p FZD3 0.477736876273128 0.22218404598603 0.792931453624831 0.000876919876092158 MirTarget -0.176344829529581 5.18462285335831e-08 NA NA NA hsa-miR-452-5p FZD3 0.637123950346362 0.0458173998136196 0.792931453624831 0.000876919876092158 mirMAP -0.178690042878829 1.67111604415628e-07 NA NA NA hsa-miR-106b-5p FZD4 1.47447672652218 1.32004094930462e-13 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.168446192536686 0.000502251662804167 NA NA NA hsa-miR-130b-3p FZD4 1.83046548750752 5.04753914574694e-13 -1.78542446608909 5.91969949280441e-18 mirMAP -0.147162792947595 0.000235559318288284 NA NA NA hsa-miR-141-3p FZD4 3.36993755486106 5.42939251147195e-32 -1.78542446608909 5.91969949280441e-18 TargetScan -0.185058884280311 5.54410805480532e-09 NA NA NA hsa-miR-15a-5p FZD4 1.62575353599172 1.55312121019827e-19 -1.78542446608909 5.91969949280441e-18 MirTarget -0.223007699123252 2.4021699884549e-05 NA NA NA hsa-miR-17-5p FZD4 2.07078488653279 2.77403038572568e-19 -1.78542446608909 5.91969949280441e-18 TargetScan -0.129489421531414 0.00166997430902038 NA NA NA hsa-miR-185-5p FZD4 1.14291034858482 2.95777119743491e-13 -1.78542446608909 5.91969949280441e-18 MirTarget -0.193616027867278 0.00179184266973846 NA NA NA hsa-miR-200c-3p FZD4 0.380533388300368 0.0842181838538353 -1.78542446608909 5.91969949280441e-18 mirMAP -0.124610785675869 0.00562310667443679 NA NA NA hsa-miR-20a-5p FZD4 2.64649625616975 5.1469418982085e-27 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.129564434466346 0.000625869837775908 NA NA NA hsa-miR-21-5p FZD4 4.38165933891779 1.52536633902505e-92 -1.78542446608909 5.91969949280441e-18 mirMAP -0.290057279466341 2.0794512089728e-15 NA NA NA hsa-miR-22-5p FZD4 1.71436244278242 9.85038001236064e-15 -1.78542446608909 5.91969949280441e-18 mirMAP -0.118299378985615 0.00647964972242759 NA NA NA hsa-miR-301a-3p FZD4 2.70198002906399 1.56420889710984e-14 -1.78542446608909 5.91969949280441e-18 mirMAP -0.119699842207105 0.000390249364993268 NA NA NA hsa-miR-3127-5p FZD4 0.382717393698386 0.11535780874721 -1.78542446608909 5.91969949280441e-18 MirTarget -0.136235829435325 0.00081187616650683 NA NA NA hsa-miR-424-5p FZD4 1.26485330287919 6.1498991028257e-06 -1.78542446608909 5.91969949280441e-18 MirTarget -0.108389004937805 0.00194952577602808 NA NA NA hsa-miR-429 FZD4 2.3794516574089 1.72813419703734e-13 -1.78542446608909 5.91969949280441e-18 mirMAP -0.14020480629482 1.26422902483956e-05 NA NA NA hsa-miR-452-5p FZD4 0.637123950346362 0.0458173998136196 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.102142755118398 0.000946827382301665 NA NA NA hsa-miR-542-3p FZD4 1.62226640768239 2.6427102465476e-10 -1.78542446608909 5.91969949280441e-18 mirMAP;miRNATAP -0.173071737031192 3.99942378374425e-06 NA NA NA hsa-miR-590-3p FZD4 0.83851360565783 0.00129224433453587 -1.78542446608909 5.91969949280441e-18 miRanda;mirMAP;miRNATAP -0.125164665887518 0.00584820326674969 NA NA NA hsa-miR-590-5p FZD4 2.07441240363458 4.95240551694843e-14 -1.78542446608909 5.91969949280441e-18 mirMAP -0.184657349030045 1.86727859822008e-05 NA NA NA hsa-miR-7-1-3p FZD4 2.61364240402652 1.98959237815786e-32 -1.78542446608909 5.91969949280441e-18 mirMAP -0.185757427372638 2.33266926699486e-05 NA NA NA hsa-miR-708-5p FZD4 3.04047795672813 3.01085192850869e-20 -1.78542446608909 5.91969949280441e-18 miRNATAP -0.109647717679213 0.000615279688227838 NA NA NA hsa-miR-98-5p FZD4 1.170602085804 1.09900501665229e-08 -1.78542446608909 5.91969949280441e-18 MirTarget -0.19236058291101 7.98426929301211e-05 NA NA NA hsa-let-7a-3p FZD5 0.167285443861993 0.431834813181487 -0.705926982163628 0.000105007898539503 miRNATAP -0.115040442140511 0.00992055050107584 NA NA NA hsa-miR-100-5p FZD5 0.423440403609931 0.104072937074013 -0.705926982163628 0.000105007898539503 MirTarget;miRNATAP -0.103599747968345 0.00136344793062504 NA NA NA hsa-miR-142-5p FZD5 1.29672439149353 4.0768822158894e-06 -0.705926982163628 0.000105007898539503 mirMAP -0.202548530400874 1.53436002794766e-10 NA NA NA hsa-miR-155-5p FZD5 0.813513839059142 0.000608282725633232 -0.705926982163628 0.000105007898539503 miRNATAP -0.268794133777123 5.99765164934705e-15 NA NA NA hsa-miR-191-5p FZD5 0.343645878547116 0.0668114086143391 -0.705926982163628 0.000105007898539503 miRNATAP -0.120521800227365 0.00771147788637244 NA NA NA hsa-miR-22-5p FZD5 1.71436244278242 9.85038001236064e-15 -0.705926982163628 0.000105007898539503 mirMAP -0.188436559704749 2.77750440904441e-07 NA NA NA hsa-miR-23a-3p FZD5 0.111958289789488 0.393086414480463 -0.705926982163628 0.000105007898539503 miRNATAP -0.254562167715161 9.45722420510268e-05 NA NA NA hsa-miR-342-3p FZD5 -0.128691966564961 0.561034080130801 -0.705926982163628 0.000105007898539503 PITA -0.23768020919403 2.58235345026286e-10 NA NA NA hsa-miR-409-3p FZD5 0.476201525793412 0.182989887810807 -0.705926982163628 0.000105007898539503 mirMAP -0.120279985399845 2.48814905463711e-07 NA NA NA hsa-miR-450b-5p FZD5 1.69248953402469 1.96052058003353e-07 -0.705926982163628 0.000105007898539503 mirMAP -0.152206586253227 7.34002441589538e-08 NA NA NA hsa-miR-493-5p FZD5 0.491314139739658 0.134743813669005 -0.705926982163628 0.000105007898539503 mirMAP -0.128674633229396 4.07693171229115e-07 NA NA NA hsa-miR-590-3p FZD5 0.83851360565783 0.00129224433453587 -0.705926982163628 0.000105007898539503 miRanda -0.145384661603229 0.000164475405289106 NA NA NA hsa-miR-19b-3p FZD6 2.10868505662119 5.40846613768389e-17 -0.48976932567242 0.00666897711463193 MirTarget -0.109318379651282 0.001165413337554 NA NA NA hsa-miR-342-3p FZD6 -0.128691966564961 0.561034080130801 -0.48976932567242 0.00666897711463193 miRanda -0.106705130249982 0.00473208370808566 NA NA NA hsa-miR-106b-5p FZD7 1.47447672652218 1.32004094930462e-13 -0.805873120798978 0.000200127022595004 miRNATAP -0.146269360972519 0.00296533184264331 NA NA NA hsa-miR-130b-5p FZD7 1.53645187062942 1.10498816261505e-08 -0.805873120798978 0.000200127022595004 mirMAP -0.16451251495499 6.6387497439697e-06 NA NA NA hsa-miR-142-3p FZD7 3.98476449801341 1.56256182021111e-35 -0.805873120798978 0.000200127022595004 miRanda -0.101123750615978 0.000461409281641207 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-186-5p FZD7 0.852175445703945 6.88885738584309e-10 -0.805873120798978 0.000200127022595004 mirMAP -0.229921225466784 0.00145584804153626 NA NA NA hsa-miR-20a-5p FZD7 2.64649625616975 5.1469418982085e-27 -0.805873120798978 0.000200127022595004 miRNATAP -0.112486804586343 0.00349764834916661 NA NA NA hsa-miR-2355-5p FZD7 1.86174980095465 3.47492783095613e-13 -0.805873120798978 0.000200127022595004 MirTarget -0.130245339966042 0.00167912388768476 NA NA NA hsa-miR-335-3p FZD7 1.51116383169018 6.88553098788624e-13 -0.805873120798978 0.000200127022595004 mirMAP -0.174687541232076 0.000171920205098716 NA NA NA hsa-miR-590-3p FZD7 0.83851360565783 0.00129224433453587 -0.805873120798978 0.000200127022595004 miRanda -0.151266288868364 0.00101249610871224 NA NA NA hsa-miR-100-5p FZD8 0.423440403609931 0.104072937074013 -0.671875080608357 0.00760811728424741 MirTarget -0.15045328970468 0.000737292478688576 NA NA NA hsa-miR-192-5p FZD9 2.03412119423736 1.6357945826287e-05 0.900936731866829 0.109819964845664 miRNATAP -0.257658573611763 1.82050748836927e-06 NA NA NA hsa-miR-141-3p GDF6 3.36993755486106 5.42939251147195e-32 -1.5194862108318 0.00056291628560495 TargetScan -0.427196739671682 5.68956880278445e-11 NA NA NA hsa-miR-141-5p GDF6 3.02575703771074 1.54385222591327e-32 -1.5194862108318 0.00056291628560495 mirMAP -0.370992821731478 5.24279913341381e-07 NA NA NA hsa-miR-200b-3p GDF6 1.55157578247391 4.83790020897188e-09 -1.5194862108318 0.00056291628560495 TargetScan -0.407404371428973 5.32003566043286e-08 NA NA NA hsa-miR-30d-3p GDF6 0.00396376345349925 0.986457040013182 -1.5194862108318 0.00056291628560495 miRNATAP -0.25388033197001 0.009877873449128 NA NA NA hsa-miR-429 GDF6 2.3794516574089 1.72813419703734e-13 -1.5194862108318 0.00056291628560495 PITA;miRanda;miRNATAP -0.321975993833869 1.1141613016749e-06 NA NA NA hsa-miR-141-3p GLI2 3.36993755486106 5.42939251147195e-32 -0.141260959221836 0.587842992247211 MirTarget -0.114053085449078 0.00346673995743498 NA NA NA hsa-miR-15b-3p GLI2 0.804736041893915 0.000400279611457186 -0.141260959221836 0.587842992247211 mirMAP -0.191229154621916 0.000553285783092511 NA NA NA hsa-miR-182-5p GLI2 3.21839823004635 5.13049145201115e-39 -0.141260959221836 0.587842992247211 MirTarget -0.222459694882916 5.06458496813457e-07 NA NA NA hsa-miR-146b-5p GSK3B 1.0922867893808 5.63754607494775e-06 -0.319504109269896 0.00509554373726706 miRanda -0.120312213108812 1.7975506993317e-08 NA NA NA hsa-miR-181a-5p GSK3B -0.375429731222937 0.0562142867129802 -0.319504109269896 0.00509554373726706 mirMAP -0.132846513131072 5.69040547461192e-07 NA NA NA hsa-miR-181b-5p GSK3B 0.668793269169928 0.000239998092406404 -0.319504109269896 0.00509554373726706 mirMAP -0.140685251831582 8.58107584485064e-07 NA NA NA hsa-miR-199a-5p GSK3B 1.3057193856884 2.38429382751645e-08 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.121841478766833 2.53412001096022e-08 NA NA NA hsa-miR-199b-5p GSK3B 2.13822205171062 4.56262988762436e-15 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.100321514688164 5.34622168763933e-08 NA NA NA hsa-miR-26b-5p GSK3B 0.72362441215247 4.7794659748036e-05 -0.319504109269896 0.00509554373726706 miRNATAP -0.157953924331919 5.91797033962096e-08 NA NA NA hsa-miR-29a-3p GSK3B 0.101650412194573 0.573201097011668 -0.319504109269896 0.00509554373726706 miRNATAP -0.116338386401065 6.72434775060363e-05 NA NA NA hsa-miR-29b-3p GSK3B 3.10527711861309 3.01242507282711e-32 -0.319504109269896 0.00509554373726706 miRTarBase;miRNATAP -0.120996712920378 3.47881082150066e-11 NA NA NA hsa-miR-342-3p GSK3B -0.128691966564961 0.561034080130801 -0.319504109269896 0.00509554373726706 miRanda -0.118246314250764 5.34302901573344e-07 NA NA NA hsa-miR-664a-3p GSK3B 0.443077463053857 0.0214248925850984 -0.319504109269896 0.00509554373726706 mirMAP -0.143789851437302 1.0690658876804e-07 NA NA NA hsa-miR-19b-3p ID2 2.10868505662119 5.40846613768389e-17 -1.25480152265325 4.20094211960508e-09 MirTarget;miRNATAP -0.112548618093552 0.00543501898035558 NA NA NA hsa-miR-27a-3p ID2 0.433402568013802 0.00737164631768323 -1.25480152265325 4.20094211960508e-09 MirTarget;miRNATAP -0.281027438531934 5.49573953021193e-06 NA NA NA hsa-miR-335-5p ITGB2 -0.466533891325811 0.0676987038122831 -0.760215144931324 0.00662771263583997 miRNAWalker2_validate -0.187075605999821 0.000959221407098934 NA NA NA hsa-miR-429 ITGB2 2.3794516574089 1.72813419703734e-13 -0.760215144931324 0.00662771263583997 miRanda -0.219817109627773 1.45681341741766e-07 NA NA NA hsa-miR-15a-5p LATS1 1.62575353599172 1.55312121019827e-19 -0.447822414619614 0.00448864298940338 MirTarget;miRNATAP -0.228795231755474 2.67013781402825e-09 NA NA NA hsa-miR-16-5p LATS1 0.749619098384047 4.11649450706988e-06 -0.447822414619614 0.00448864298940338 miRNAWalker2_validate;MirTarget;miRNATAP -0.141327561968826 0.00151761807447412 NA NA NA hsa-miR-181a-5p LATS1 -0.375429731222937 0.0562142867129802 -0.447822414619614 0.00448864298940338 MirTarget;miRNATAP -0.130203681407229 0.0004392343752272 NA NA NA hsa-miR-181b-5p LATS1 0.668793269169928 0.000239998092406404 -0.447822414619614 0.00448864298940338 MirTarget;miRNATAP -0.140687068101602 0.000413678250255137 NA NA NA hsa-miR-19b-1-5p LATS1 1.71217036351784 3.28561659177495e-12 -0.447822414619614 0.00448864298940338 MirTarget -0.117316357063956 0.000434444024177967 NA NA NA hsa-miR-21-5p LATS1 4.38165933891779 1.52536633902505e-92 -0.447822414619614 0.00448864298940338 miRNAWalker2_validate -0.10490693165907 0.000141065138433488 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-29a-5p LATS1 1.89519956688438 1.03453349363915e-11 -0.447822414619614 0.00448864298940338 MirTarget -0.205351073391991 6.41728707326166e-12 NA NA NA hsa-miR-32-5p LATS1 0.876853679269853 6.04859399018691e-05 -0.447822414619614 0.00448864298940338 miRNATAP -0.103266791066715 0.00407476056415288 NA NA NA hsa-miR-450b-5p LATS1 1.69248953402469 1.96052058003353e-07 -0.447822414619614 0.00448864298940338 mirMAP -0.110725246950747 6.14258496985936e-06 NA NA NA hsa-miR-497-5p LATS1 -0.0546347378264729 0.786205564901684 -0.447822414619614 0.00448864298940338 MirTarget;miRNATAP -0.120316944230198 0.000898928060572496 NA NA NA hsa-miR-590-5p LATS1 2.07441240363458 4.95240551694843e-14 -0.447822414619614 0.00448864298940338 miRanda;miRNATAP -0.100822738662549 0.00154907313949462 NA NA NA hsa-miR-103a-3p LATS2 0.538497806383155 1.88134691850591e-05 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.289716154022884 1.88057780089563e-07 27602163 Furthermore miR-103 repressed large tumor suppressor kinase 2 LATS2 expression by directly binding to the LATS2-3'-untranslated region and an inverse correlation was identified between the expression of miR-103 and LATS2 messenger RNA in primary CRC tissues; In summary miR-103 performs a critical role in the promotion of the invasive and metastatic capacities of CRC possibly by directly targeting LATS2 colorectal cancer hsa-miR-107 LATS2 0.658676029898313 5.11480446318819e-07 -1.31460097903989 2.33618473997196e-19 PITA;miRanda;miRNATAP -0.18751001945892 0.000454287513200308 NA NA NA hsa-miR-130b-5p LATS2 1.53645187062942 1.10498816261505e-08 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.167257594932113 2.9173094500087e-11 NA NA NA hsa-miR-15a-5p LATS2 1.62575353599172 1.55312121019827e-19 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.236363714957646 1.5407260091191e-10 NA NA NA hsa-miR-16-5p LATS2 0.749619098384047 4.11649450706988e-06 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.171273988603932 6.25788427868163e-05 NA NA NA hsa-miR-200b-3p LATS2 1.55157578247391 4.83790020897188e-09 -1.31460097903989 2.33618473997196e-19 TargetScan -0.18159196879082 8.69925558109472e-13 NA NA NA hsa-miR-200c-3p LATS2 0.380533388300368 0.0842181838538353 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.117317983960895 0.000220805324852975 NA NA NA hsa-miR-25-3p LATS2 0.361927330834176 0.0163670566170988 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.209763059012061 6.69760903955829e-06 25179841 MiR 25 promotes ovarian cancer proliferation and motility by targeting LATS2; Large tumor suppressor 2 LATS2 a tumor suppressor was confirmed to be a direct target of miR-25 in OC cells; Moreover restoration of LATS2 significantly attenuated the oncogenic effects of miR-25 motility ovarian cancer hsa-miR-32-5p LATS2 0.876853679269853 6.04859399018691e-05 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.105643704115111 0.00226968888093998 NA NA NA hsa-miR-429 LATS2 2.3794516574089 1.72813419703734e-13 -1.31460097903989 2.33618473997196e-19 PITA;miRanda;miRNATAP -0.213464504301666 1.45431578332437e-22 NA NA NA hsa-miR-590-3p LATS2 0.83851360565783 0.00129224433453587 -1.31460097903989 2.33618473997196e-19 PITA;miRanda -0.100993518211086 0.00166070111966853 NA NA NA hsa-miR-93-5p LATS2 1.50844106515467 1.83836866996875e-12 -1.31460097903989 2.33618473997196e-19 miRNAWalker2_validate -0.280090345938624 8.66523713085372e-20 NA NA NA hsa-miR-96-5p LATS2 3.0381097138467 4.40362891630201e-24 -1.31460097903989 2.33618473997196e-19 miRNATAP -0.269617061716727 3.4146065050672e-29 NA NA NA hsa-miR-107 LEF1 0.658676029898313 5.11480446318819e-07 0.588024418569192 0.00773878613348744 miRanda -0.262842866172606 0.000738685814950871 NA NA NA hsa-miR-3065-3p LEF1 0.381740717819351 0.30795546546997 0.588024418569192 0.00773878613348744 miRNATAP -0.11840997118237 1.18212026315203e-05 NA NA NA hsa-miR-3065-5p LEF1 0.653308707552535 0.0999497219778851 0.588024418569192 0.00773878613348744 miRNATAP -0.130781255877128 2.27551750259261e-06 NA NA NA hsa-miR-106b-5p LIMD1 1.47447672652218 1.32004094930462e-13 -1.27386062278821 2.54374777382978e-13 mirMAP -0.171263115153253 2.00256900395898e-05 NA NA NA hsa-miR-130b-5p LIMD1 1.53645187062942 1.10498816261505e-08 -1.27386062278821 2.54374777382978e-13 mirMAP -0.209973094902298 1.02447076683666e-12 NA NA NA hsa-miR-132-3p LIMD1 0.0122601212105202 0.934032846062939 -1.27386062278821 2.54374777382978e-13 mirMAP -0.154321228491178 0.00614759236685728 NA NA NA hsa-miR-155-5p LIMD1 0.813513839059142 0.000608282725633232 -1.27386062278821 2.54374777382978e-13 mirMAP -0.160140117825118 3.07580895886765e-06 NA NA NA hsa-miR-182-5p LIMD1 3.21839823004635 5.13049145201115e-39 -1.27386062278821 2.54374777382978e-13 mirMAP -0.124072144713031 4.82564099940509e-05 NA NA NA hsa-miR-18a-5p LIMD1 1.37435209536521 9.2173853686829e-06 -1.27386062278821 2.54374777382978e-13 mirMAP -0.102967989723455 0.000297386313718654 NA NA NA hsa-miR-199a-3p LIMD1 1.67715607711377 5.96963028176444e-15 -1.27386062278821 2.54374777382978e-13 mirMAP -0.268796682120201 1.40239464134996e-13 NA NA NA hsa-miR-199a-5p LIMD1 1.3057193856884 2.38429382751645e-08 -1.27386062278821 2.54374777382978e-13 miRanda -0.133968381423247 0.000107640160918422 NA NA NA hsa-miR-199b-3p LIMD1 1.67802185853505 6.03525898173555e-15 -1.27386062278821 2.54374777382978e-13 mirMAP -0.268806309089391 1.34337196077225e-13 NA NA NA hsa-miR-199b-5p LIMD1 2.13822205171062 4.56262988762436e-15 -1.27386062278821 2.54374777382978e-13 miRanda -0.107138517405052 0.000240161678474778 NA NA NA hsa-miR-212-3p LIMD1 0.404496907089793 0.103551762277891 -1.27386062278821 2.54374777382978e-13 mirMAP -0.160107079023438 1.12679552356054e-06 NA NA NA hsa-miR-2355-5p LIMD1 1.86174980095465 3.47492783095613e-13 -1.27386062278821 2.54374777382978e-13 mirMAP -0.145338890211946 1.74107403179907e-05 NA NA NA hsa-miR-374b-3p LIMD1 -0.157526212601818 0.538677664999491 -1.27386062278821 2.54374777382978e-13 mirMAP -0.108563672224157 0.00549450132560158 NA NA NA hsa-miR-382-5p LIMD1 0.89147630851775 0.00788998149550552 -1.27386062278821 2.54374777382978e-13 mirMAP -0.153422938491055 5.01504451723585e-10 NA NA NA hsa-miR-421 LIMD1 0.170525317701774 0.535277026680289 -1.27386062278821 2.54374777382978e-13 mirMAP -0.171305418727467 1.05200505522489e-07 NA NA NA hsa-miR-450b-5p LIMD1 1.69248953402469 1.96052058003353e-07 -1.27386062278821 2.54374777382978e-13 MirTarget;mirMAP -0.188423504606558 5.43757849571575e-12 NA NA NA hsa-miR-452-5p LIMD1 0.637123950346362 0.0458173998136196 -1.27386062278821 2.54374777382978e-13 mirMAP -0.11747393589576 4.36438059442501e-06 NA NA NA hsa-miR-542-3p LIMD1 1.62226640768239 2.6427102465476e-10 -1.27386062278821 2.54374777382978e-13 miRanda;mirMAP -0.196287531340419 2.1834275049598e-10 NA NA NA hsa-miR-550a-5p LIMD1 0.59977150019756 0.0314775340172755 -1.27386062278821 2.54374777382978e-13 MirTarget -0.183740600264011 2.55565200316876e-10 NA NA NA hsa-miR-576-5p LIMD1 1.02693643167056 1.14846964470173e-06 -1.27386062278821 2.54374777382978e-13 mirMAP -0.159700769252424 3.34607580476453e-05 NA NA NA hsa-miR-590-3p LIMD1 0.83851360565783 0.00129224433453587 -1.27386062278821 2.54374777382978e-13 PITA;miRanda;mirMAP -0.200650977642106 7.90208322499702e-08 NA NA NA hsa-miR-629-5p LIMD1 1.31657090341737 1.45711558652127e-12 -1.27386062278821 2.54374777382978e-13 mirMAP -0.237931457128509 2.85777786482349e-08 NA NA NA hsa-miR-671-5p LIMD1 2.24156654191798 2.10433241567652e-14 -1.27386062278821 2.54374777382978e-13 mirMAP -0.204720127462734 1.66197144757071e-10 NA NA NA hsa-miR-7-1-3p LIMD1 2.61364240402652 1.98959237815786e-32 -1.27386062278821 2.54374777382978e-13 mirMAP -0.123584199431207 0.000751681400451573 NA NA NA hsa-miR-766-3p LIMD1 0.0784037775118556 0.760091599198293 -1.27386062278821 2.54374777382978e-13 mirMAP -0.157221484810296 7.95795820073996e-07 NA NA NA hsa-miR-93-3p LIMD1 1.07631808403007 1.63747525692813e-05 -1.27386062278821 2.54374777382978e-13 mirMAP -0.113678180150931 0.000496686069860295 NA NA NA hsa-miR-93-5p LIMD1 1.50844106515467 1.83836866996875e-12 -1.27386062278821 2.54374777382978e-13 mirMAP -0.145183872639961 0.000107211470881183 NA NA NA hsa-miR-146b-3p LLGL2 -0.808296168180355 0.000870284326590347 0.286047043494791 0.167912122637304 miRNATAP -0.115730968880156 0.00315079097098934 NA NA NA hsa-miR-140-5p MPP5 0.669142684153918 0.000335928403032308 -0.650214136806933 9.24407787146396e-08 miRanda -0.104138226267325 0.000821484596675732 NA NA NA hsa-miR-142-3p MPP5 3.98476449801341 1.56256182021111e-35 -0.650214136806933 9.24407787146396e-08 miRanda -0.1182556511027 1.15760339114147e-13 NA NA NA hsa-miR-148a-3p MPP5 2.30885799126944 1.95226081368985e-21 -0.650214136806933 9.24407787146396e-08 miRNAWalker2_validate;MirTarget -0.133816028370217 1.1314564418993e-09 NA NA NA hsa-miR-155-5p MPP5 0.813513839059142 0.000608282725633232 -0.650214136806933 9.24407787146396e-08 miRNAWalker2_validate;MirTarget -0.122492085738903 2.01665921577339e-07 NA NA NA hsa-miR-181c-5p MPP5 0.529875814537156 0.0125885822998008 -0.650214136806933 9.24407787146396e-08 MirTarget -0.118696512400846 7.82802035876029e-06 NA NA NA hsa-miR-199a-5p MPP5 1.3057193856884 2.38429382751645e-08 -0.650214136806933 9.24407787146396e-08 MirTarget;PITA;miRanda;miRNATAP -0.158032476012492 1.55075721422876e-11 NA NA NA hsa-miR-199b-5p MPP5 2.13822205171062 4.56262988762436e-15 -0.650214136806933 9.24407787146396e-08 MirTarget;PITA;miRanda -0.149014853895005 3.09438852628901e-14 NA NA NA hsa-miR-21-5p MPP5 4.38165933891779 1.52536633902505e-92 -0.650214136806933 9.24407787146396e-08 miRNAWalker2_validate -0.104386854952987 1.0470645510373e-06 NA NA NA hsa-miR-425-5p MPP5 1.21659524959201 8.01126418494715e-09 -0.650214136806933 9.24407787146396e-08 MirTarget -0.158304522545121 1.36269874457667e-09 NA NA NA hsa-miR-576-5p MPP5 1.02693643167056 1.14846964470173e-06 -0.650214136806933 9.24407787146396e-08 PITA -0.12868468656664 1.104760297639e-06 NA NA NA hsa-miR-590-5p MPP5 2.07441240363458 4.95240551694843e-14 -0.650214136806933 9.24407787146396e-08 miRanda -0.136770474772048 2.54835942519786e-08 NA NA NA hsa-miR-93-3p MPP5 1.07631808403007 1.63747525692813e-05 -0.650214136806933 9.24407787146396e-08 miRNAWalker2_validate -0.115139130524447 2.43306049962048e-07 NA NA NA hsa-miR-34a-5p MYC 1.40588612517769 8.60097477768592e-12 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate;miRTarBase -0.160523406918217 0.0041257772904121 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.3794516574089 1.72813419703734e-13 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate -0.178099724014789 2.94573429210347e-06 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-21-5p NKD1 4.38165933891779 1.52536633902505e-92 -1.734580414771 4.24665289948679e-06 mirMAP -0.393412938012472 2.27374130691586e-09 NA NA NA hsa-miR-455-5p PARD3 1.36946341828134 5.05118627562807e-08 0.167360745072316 0.297390316644785 MirTarget;miRanda;miRNATAP -0.122910384478609 0.000235867518561357 NA NA NA hsa-miR-532-5p PARD3 0.576620898517708 0.0023245812680956 0.167360745072316 0.297390316644785 MirTarget -0.106995450405475 0.00616647182974122 NA NA NA hsa-miR-146b-3p PARD6A -0.808296168180355 0.000870284326590347 -0.0255839773971251 0.909110177786028 miRNATAP -0.16544162041772 8.70698991774286e-05 NA NA NA hsa-let-7i-5p PARD6B 0.605080599172936 1.48406814653206e-06 -1.08297131628334 8.07442791379107e-09 MirTarget;miRNATAP -0.228038024947558 0.00117723784430031 NA NA NA hsa-miR-106a-5p PARD6B 1.3902608059488 6.07931522284525e-05 -1.08297131628334 8.07442791379107e-09 MirTarget;miRNATAP -0.133112424520277 1.80596588579341e-06 NA NA NA hsa-miR-140-5p PARD6B 0.669142684153918 0.000335928403032308 -1.08297131628334 8.07442791379107e-09 miRanda -0.169363720695847 0.000445516655042414 NA NA NA hsa-miR-142-3p PARD6B 3.98476449801341 1.56256182021111e-35 -1.08297131628334 8.07442791379107e-09 PITA;miRanda;miRNATAP -0.192231369995219 5.92887794966648e-15 NA NA NA hsa-miR-143-5p PARD6B 1.86670676070774 1.06290100545251e-09 -1.08297131628334 8.07442791379107e-09 MirTarget -0.170199708756233 8.34137005925598e-10 NA NA NA hsa-miR-17-5p PARD6B 2.07078488653279 2.77403038572568e-19 -1.08297131628334 8.07442791379107e-09 MirTarget;TargetScan;miRNATAP -0.220457505564479 9.79687165955118e-10 NA NA NA hsa-miR-18a-5p PARD6B 1.37435209536521 9.2173853686829e-06 -1.08297131628334 8.07442791379107e-09 miRNAWalker2_validate;MirTarget -0.165978044737609 3.52056307457348e-08 NA NA NA hsa-miR-20a-3p PARD6B 2.51803599558247 4.92479325298629e-13 -1.08297131628334 8.07442791379107e-09 mirMAP -0.160990414837882 3.03191784417296e-07 NA NA NA hsa-miR-20a-5p PARD6B 2.64649625616975 5.1469418982085e-27 -1.08297131628334 8.07442791379107e-09 MirTarget;miRNATAP -0.176858356617212 1.15042016775372e-07 NA NA NA hsa-miR-20b-5p PARD6B 1.35770573270947 0.00260808530013016 -1.08297131628334 8.07442791379107e-09 MirTarget;miRNATAP -0.133556746626992 2.67769884280046e-11 NA NA NA hsa-miR-223-3p PARD6B -0.51475567451355 0.0609181549839239 -1.08297131628334 8.07442791379107e-09 MirTarget -0.108874376845884 0.000646766610147017 NA NA NA hsa-miR-2355-3p PARD6B 1.10676344164715 6.24068383465151e-06 -1.08297131628334 8.07442791379107e-09 MirTarget;miRNATAP -0.104955313366476 0.00521251654927314 NA NA NA hsa-miR-3607-3p PARD6B 2.4103172144469 2.69039449048047e-08 -1.08297131628334 8.07442791379107e-09 mirMAP -0.1080834384894 3.99072424064767e-08 NA NA NA hsa-miR-409-3p PARD6B 0.476201525793412 0.182989887810807 -1.08297131628334 8.07442791379107e-09 PITA -0.105600333822255 1.50171780742501e-05 NA NA NA hsa-miR-576-5p PARD6B 1.02693643167056 1.14846964470173e-06 -1.08297131628334 8.07442791379107e-09 mirMAP -0.156088238538606 0.000148973416879079 NA NA NA hsa-miR-582-5p PARD6B 1.08286181406653 0.00149040450161757 -1.08297131628334 8.07442791379107e-09 MirTarget;PITA;miRNATAP -0.14850283291772 1.06262787399207e-08 NA NA NA hsa-miR-92a-3p PARD6B -0.136362762339122 0.493412263619364 -1.08297131628334 8.07442791379107e-09 mirMAP -0.138458603235329 0.00179062659318123 NA NA NA hsa-miR-93-5p PARD6B 1.50844106515467 1.83836866996875e-12 -1.08297131628334 8.07442791379107e-09 MirTarget;miRNATAP -0.216688338970167 4.78986263504518e-08 NA NA NA hsa-miR-146b-5p PARD6G 1.0922867893808 5.63754607494775e-06 -0.151320743861273 0.441231216831858 miRanda -0.14368330127219 0.000108385302121008 NA NA NA hsa-miR-140-3p PPP1CB -1.11373309124537 8.35257079443689e-14 0.0873631569033222 0.430871470652716 miRNATAP -0.243328456589781 9.12886409642435e-14 NA NA NA hsa-miR-140-5p PPP1CB 0.669142684153918 0.000335928403032308 0.0873631569033222 0.430871470652716 miRanda -0.11436394715603 3.96136152701038e-05 NA NA NA hsa-miR-181a-5p PPP1CB -0.375429731222937 0.0562142867129802 0.0873631569033222 0.430871470652716 mirMAP;miRNATAP -0.169027436957437 3.15579069497028e-11 NA NA NA hsa-miR-195-3p PPP1CB -1.33068822339418 6.65427393047357e-09 0.0873631569033222 0.430871470652716 miRNATAP -0.133921277548825 5.15627625994304e-10 NA NA NA hsa-miR-320a PPP1CB -0.961144925954715 1.62478794429204e-08 0.0873631569033222 0.430871470652716 miRNATAP -0.134734317761562 4.65618543204679e-06 NA NA NA hsa-miR-455-5p PPP1CB 1.36946341828134 5.05118627562807e-08 0.0873631569033222 0.430871470652716 PITA;miRanda -0.149598759997383 3.95011933061361e-11 NA NA NA hsa-miR-484 PPP1CB -0.228576985124486 0.244112867390855 0.0873631569033222 0.430871470652716 miRNATAP -0.14428545055475 2.00437236288116e-08 NA NA NA hsa-miR-664a-3p PPP1CB 0.443077463053857 0.0214248925850984 0.0873631569033222 0.430871470652716 mirMAP -0.204768022110605 1.67851221689476e-15 NA NA NA hsa-let-7a-3p PPP1CC 0.167285443861993 0.431834813181487 0.14862984928136 0.172735526583351 mirMAP -0.130460425813307 6.27478070572965e-07 NA NA NA hsa-let-7b-3p PPP1CC -1.81889978084306 6.9913416210266e-19 0.14862984928136 0.172735526583351 mirMAP -0.143880272529065 4.95702324511746e-10 NA NA NA hsa-let-7f-1-3p PPP1CC -0.0921261289038979 0.693970843315065 0.14862984928136 0.172735526583351 mirMAP -0.10590111831766 6.72304365739423e-05 NA NA NA hsa-miR-140-5p PPP1CC 0.669142684153918 0.000335928403032308 0.14862984928136 0.172735526583351 PITA;miRanda;miRNATAP -0.102638826106116 0.000180276571116407 NA NA NA hsa-miR-218-5p PPP1CC -0.281408491748349 0.259553612322657 0.14862984928136 0.172735526583351 miRNATAP -0.131094155020589 8.90040263146338e-11 NA NA NA hsa-miR-26a-5p PPP1CC -0.126411409001078 0.440028840408711 0.14862984928136 0.172735526583351 miRNAWalker2_validate -0.103235841569694 0.000794412329745643 NA NA NA hsa-miR-26b-5p PPP1CC 0.72362441215247 4.7794659748036e-05 0.14862984928136 0.172735526583351 miRNAWalker2_validate -0.118130186764764 2.31016601251941e-05 NA NA NA hsa-miR-27b-3p PPP1CC 0.236438984240408 0.12263510345883 0.14862984928136 0.172735526583351 miRNATAP -0.148163206608748 6.12980795229894e-06 NA NA NA hsa-miR-30a-5p PPP1CC -0.924084264430689 0.000762030454634728 0.14862984928136 0.172735526583351 miRNAWalker2_validate -0.141514259097762 8.49028081759173e-16 NA NA NA hsa-miR-125a-5p PPP2CA -1.04824536696301 3.97386082850476e-07 0.00351977565606187 0.97004225712613 miRanda -0.108592476267422 9.06041337720993e-08 NA NA NA hsa-miR-30c-5p PPP2CA -0.327319105755825 0.123595832152687 0.00351977565606187 0.97004225712613 mirMAP -0.131381693408342 3.54219270743565e-11 NA NA NA hsa-miR-664a-3p PPP2CA 0.443077463053857 0.0214248925850984 0.00351977565606187 0.97004225712613 mirMAP -0.129991418169681 3.46486829402912e-09 NA NA NA hsa-miR-183-5p PPP2CB 2.39247234736657 3.92444525331999e-21 -0.810479191024634 2.22590279447859e-10 MirTarget;miRNATAP -0.107046241719826 1.76590312582065e-06 NA NA NA hsa-miR-421 PPP2CB 0.170525317701774 0.535277026680289 -0.810479191024634 2.22590279447859e-10 miRNAWalker2_validate;miRanda -0.101748717017346 1.55432203300377e-05 NA NA NA hsa-miR-425-5p PPP2CB 1.21659524959201 8.01126418494715e-09 -0.810479191024634 2.22590279447859e-10 miRNAWalker2_validate -0.230017713976039 2.01900497107045e-17 NA NA NA hsa-miR-590-3p PPP2CB 0.83851360565783 0.00129224433453587 -0.810479191024634 2.22590279447859e-10 miRanda -0.115437970142581 2.41175906636951e-05 NA NA NA hsa-let-7b-3p PPP2R1B -1.81889978084306 6.9913416210266e-19 0.389306891256743 0.0156214207023678 mirMAP -0.12563396102696 0.000308074800959593 NA NA NA hsa-miR-125a-5p PPP2R1B -1.04824536696301 3.97386082850476e-07 0.389306891256743 0.0156214207023678 PITA;miRanda -0.195127723279487 2.8467995200931e-08 NA NA NA hsa-miR-139-5p PPP2R1B -2.26625553116965 7.22375119369519e-16 0.389306891256743 0.0156214207023678 MirTarget;miRanda -0.141997973480572 1.83424283877756e-08 NA NA NA hsa-miR-146b-5p PPP2R1B 1.0922867893808 5.63754607494775e-06 0.389306891256743 0.0156214207023678 miRanda -0.153736063085509 3.91553637047229e-07 NA NA NA hsa-miR-195-5p PPP2R1B -1.01577502605386 4.80814718341729e-05 0.389306891256743 0.0156214207023678 MirTarget -0.160400894716198 1.92075736299728e-07 NA NA NA hsa-miR-30a-3p PPP2R1B -2.54042202792785 2.9111625410859e-18 0.389306891256743 0.0156214207023678 mirMAP -0.105044026185593 1.59679854839767e-05 NA NA NA hsa-miR-30a-5p PPP2R1B -0.924084264430689 0.000762030454634728 0.389306891256743 0.0156214207023678 miRNATAP -0.144523567937466 5.55199488995584e-08 NA NA NA hsa-miR-30b-5p PPP2R1B 0.358144314839612 0.138026229059594 0.389306891256743 0.0156214207023678 miRNATAP -0.176137121142005 6.61523702854927e-09 NA NA NA hsa-miR-30c-2-3p PPP2R1B -3.10905250533941 6.84550165664783e-27 0.389306891256743 0.0156214207023678 MirTarget -0.104611308214946 1.32100635149458e-05 NA NA NA hsa-miR-30c-5p PPP2R1B -0.327319105755825 0.123595832152687 0.389306891256743 0.0156214207023678 miRNATAP -0.186116442727994 7.75959880994156e-08 NA NA NA hsa-miR-30d-3p PPP2R1B 0.00396376345349925 0.986457040013182 0.389306891256743 0.0156214207023678 mirMAP -0.162627010104191 4.61956599491588e-06 NA NA NA hsa-miR-30d-5p PPP2R1B -0.920901858717441 3.50898334321668e-05 0.389306891256743 0.0156214207023678 miRNATAP -0.166997113759972 3.71778141719134e-07 NA NA NA hsa-miR-497-5p PPP2R1B -0.0546347378264729 0.786205564901684 0.389306891256743 0.0156214207023678 MirTarget -0.240684090468845 3.54495469439715e-11 NA NA NA hsa-miR-500a-5p PPP2R2A 0.648155655714409 0.0104657432932038 0.0610689916481766 0.662377371351536 MirTarget -0.13814413769406 7.97915323474903e-08 NA NA NA hsa-miR-107 PPP2R2B 0.658676029898313 5.11480446318819e-07 -0.27163412728623 0.372359484020823 miRanda -0.337356946296675 0.00165068158338141 NA NA NA hsa-miR-141-3p PPP2R2B 3.36993755486106 5.42939251147195e-32 -0.27163412728623 0.372359484020823 TargetScan -0.26084558997887 6.79355201656557e-09 NA NA NA hsa-miR-181a-2-3p PPP2R2C -0.0760679893470186 0.687414621472156 2.23743913738767 0.00280304997022731 MirTarget -0.629334737531362 0.000630122490278799 NA NA NA hsa-miR-181b-5p PPP2R2C 0.668793269169928 0.000239998092406404 2.23743913738767 0.00280304997022731 mirMAP -0.947207807885688 5.07193085421739e-07 NA NA NA hsa-miR-500a-3p PPP2R2C -0.137335632790721 0.545751862031252 2.23743913738767 0.00280304997022731 MirTarget -0.440317085037529 0.00397879069860919 NA NA NA hsa-miR-140-3p PPP2R2D -1.11373309124537 8.35257079443689e-14 0.163212402060736 0.113986847000437 mirMAP -0.167155460525702 5.876516980066e-08 NA NA NA hsa-miR-199a-3p PRKCI 1.67715607711377 5.96963028176444e-15 0.00170266623858062 0.990893202108316 PITA -0.11741856860063 0.000144297735694237 NA NA NA hsa-miR-199a-5p PRKCI 1.3057193856884 2.38429382751645e-08 0.00170266623858062 0.990893202108316 miRanda -0.144964522859987 4.09517007641776e-07 NA NA NA hsa-miR-199b-3p PRKCI 1.67802185853505 6.03525898173555e-15 0.00170266623858062 0.990893202108316 PITA -0.117319125080297 0.000144648097922376 NA NA NA hsa-miR-199b-5p PRKCI 2.13822205171062 4.56262988762436e-15 0.00170266623858062 0.990893202108316 miRanda -0.111817408314125 3.7367946504443e-06 NA NA NA hsa-miR-29a-5p PRKCI 1.89519956688438 1.03453349363915e-11 0.00170266623858062 0.990893202108316 mirMAP -0.131778072580473 3.92259400309867e-06 NA NA NA hsa-miR-664a-3p PRKCI 0.443077463053857 0.0214248925850984 0.00170266623858062 0.990893202108316 mirMAP -0.120274505958682 0.000735464913177624 NA NA NA hsa-miR-152-3p PRKCZ 0.65734581993875 0.00129552561132481 -1.05095983673329 4.5196225801464e-06 MirTarget -0.167933746083516 0.00126489170561634 NA NA NA hsa-miR-193a-3p PRKCZ 0.549173467360291 0.0319030569365466 -1.05095983673329 4.5196225801464e-06 miRanda -0.159832457628994 0.000393685896826662 NA NA NA hsa-miR-744-5p RASSF1 -0.490424133130113 0.00934825173175428 -0.492735624139588 2.32227085230114e-05 miRNAWalker2_validate -0.103347494370685 0.000297535888238654 NA NA NA hsa-miR-130a-3p RASSF6 0.881660100597014 0.000158893668519248 0.78313493413318 0.0122299622370888 mirMAP -0.183437838020274 0.00287440939687949 NA NA NA hsa-miR-16-1-3p RASSF6 1.50034693398929 6.63958242991125e-10 0.78313493413318 0.0122299622370888 mirMAP -0.269228204758843 0.000199567196669419 NA NA NA hsa-miR-181a-5p RASSF6 -0.375429731222937 0.0562142867129802 0.78313493413318 0.0122299622370888 miRNAWalker2_validate -0.333051939727552 5.38818062905295e-06 NA NA NA hsa-miR-195-3p RASSF6 -1.33068822339418 6.65427393047357e-09 0.78313493413318 0.0122299622370888 mirMAP -0.19087428358778 0.00213795240151517 NA NA NA hsa-miR-30d-3p RASSF6 0.00396376345349925 0.986457040013182 0.78313493413318 0.0122299622370888 MirTarget -0.276294537748321 6.59168032436731e-05 NA NA NA hsa-miR-30e-3p RASSF6 -0.104420043859122 0.526240453209293 0.78313493413318 0.0122299622370888 MirTarget -0.27218829620366 0.00207600368517257 NA NA NA hsa-miR-339-5p RASSF6 0.536997313601114 0.0488090394176611 0.78313493413318 0.0122299622370888 miRanda -0.152187194594071 0.00403500296896629 NA NA NA hsa-miR-454-3p RASSF6 1.49453641052169 4.46235742871434e-09 0.78313493413318 0.0122299622370888 mirMAP -0.206047221856018 0.00201316236157006 NA NA NA hsa-miR-532-5p RASSF6 0.576620898517708 0.0023245812680956 0.78313493413318 0.0122299622370888 MirTarget -0.266854094377782 0.000461186789709933 NA NA NA hsa-miR-664a-3p RASSF6 0.443077463053857 0.0214248925850984 0.78313493413318 0.0122299622370888 mirMAP -0.228330986214508 0.00238240014326417 NA NA NA hsa-miR-92a-3p RASSF6 -0.136362762339122 0.493412263619364 0.78313493413318 0.0122299622370888 mirMAP -0.303115809305391 2.92877532602638e-05 NA NA NA hsa-miR-186-5p SAV1 0.852175445703945 6.88885738584309e-10 -0.411641497620271 0.0003630536781512 mirMAP -0.145359449351015 0.000143506474283772 NA NA NA hsa-miR-664a-3p SAV1 0.443077463053857 0.0214248925850984 -0.411641497620271 0.0003630536781512 mirMAP -0.103823688307509 0.000174825853863585 NA NA NA hsa-miR-30b-5p SERPINE1 0.358144314839612 0.138026229059594 -0.114178653022812 0.73682517077286 MirTarget -0.358064427205798 2.30487975154751e-08 25170877 miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells gastric cancer hsa-miR-30c-5p SERPINE1 -0.327319105755825 0.123595832152687 -0.114178653022812 0.73682517077286 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.284046002981584 0.00011264609085013 NA NA NA hsa-miR-30d-5p SERPINE1 -0.920901858717441 3.50898334321668e-05 -0.114178653022812 0.73682517077286 miRNATAP -0.387251756384648 2.03451245658885e-08 NA NA NA hsa-miR-17-5p SMAD1 2.07078488653279 2.77403038572568e-19 0.223691842310708 0.167157567472858 TargetScan -0.122530442476086 7.40091122482689e-05 NA NA NA hsa-miR-26b-5p SMAD1 0.72362441215247 4.7794659748036e-05 0.223691842310708 0.167157567472858 MirTarget -0.131433099696036 0.00165048418282586 25761878;27027434 Luciferase reporter assay confirmed the interaction of miR-26b with the 3' untranslated regions UTRs of CTGF and Smad1;Twist1 related miR 26b 5p suppresses epithelial mesenchymal transition migration and invasion by targeting SMAD1 in hepatocellular carcinoma; Subsequent investigation revealed that miR-26b-5p directly inhibited SMAD family member 1 SMAD1 expression; miR-26b-5p repressed BMP4/Smad1 signaling following SMAD1 inhibition; Overexpression of SMAD1 reversed the function of miR-26b-5p; In human HCC tissues and mouse xenograft tumors miR-26b-5p levels were inversely correlated with SMAD1 expression as well as metastasis; miR-26b-5p suppresses Twist1-induced EMT invasion and metastasis of HCC cells by targeting SMAD1 and BMP4/Smad1 signaling ;metastasis sarcoma;liver cancer hsa-miR-30a-5p SMAD1 -0.924084264430689 0.000762030454634728 0.223691842310708 0.167157567472858 miRNAWalker2_validate;miRTarBase -0.105207381450057 9.18460144313314e-05 NA NA NA hsa-miR-30b-5p SMAD1 0.358144314839612 0.138026229059594 0.223691842310708 0.167157567472858 miRNAWalker2_validate;miRTarBase -0.131045165532035 1.9975630362596e-05 NA NA NA hsa-miR-30c-5p SMAD1 -0.327319105755825 0.123595832152687 0.223691842310708 0.167157567472858 miRNAWalker2_validate;miRTarBase -0.156383914403825 7.55414770850354e-06 NA NA NA hsa-miR-30d-5p SMAD1 -0.920901858717441 3.50898334321668e-05 0.223691842310708 0.167157567472858 miRNAWalker2_validate;miRTarBase -0.124634234140244 0.000172217361165265 NA NA NA hsa-miR-146b-5p SMAD2 1.0922867893808 5.63754607494775e-06 -0.303598966729702 0.0159514222596008 mirMAP -0.124747200476988 1.31693635704313e-07 NA NA NA hsa-miR-181a-5p SMAD2 -0.375429731222937 0.0562142867129802 -0.303598966729702 0.0159514222596008 mirMAP -0.100760447867236 0.000646706434692283 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 0.668793269169928 0.000239998092406404 -0.303598966729702 0.0159514222596008 mirMAP -0.12955227917762 4.345362949562e-05 NA NA NA hsa-miR-361-5p SMAD2 0.21454431962475 0.0800957579368424 -0.303598966729702 0.0159514222596008 MirTarget -0.182189359256109 0.000148630910578159 NA NA NA hsa-miR-362-5p SMAD2 0.658947634569393 0.0243306847205756 -0.303598966729702 0.0159514222596008 mirMAP -0.106469252000328 1.13100823986564e-07 NA NA NA hsa-miR-450b-5p SMAD2 1.69248953402469 1.96052058003353e-07 -0.303598966729702 0.0159514222596008 mirMAP -0.113530038108809 4.67112154448759e-09 NA NA NA hsa-miR-501-5p SMAD2 0.411357595674671 0.10435288464149 -0.303598966729702 0.0159514222596008 mirMAP -0.107502701254072 2.2464520729965e-06 NA NA NA hsa-miR-532-5p SMAD2 0.576620898517708 0.0023245812680956 -0.303598966729702 0.0159514222596008 MirTarget -0.12142437459949 6.98911386285879e-05 NA NA NA hsa-miR-542-3p SMAD2 1.62226640768239 2.6427102465476e-10 -0.303598966729702 0.0159514222596008 PITA -0.122748876655511 2.00012298893724e-08 NA NA NA hsa-miR-16-5p SMAD3 0.749619098384047 4.11649450706988e-06 -0.104935015261858 0.513761397736816 MirTarget -0.134568029960143 0.00296658337663515 NA NA NA hsa-miR-17-5p SMAD3 2.07078488653279 2.77403038572568e-19 -0.104935015261858 0.513761397736816 miRNAWalker2_validate -0.114025973647647 0.000202733731547773 NA NA NA hsa-miR-30d-3p SMAD3 0.00396376345349925 0.986457040013182 -0.104935015261858 0.513761397736816 mirMAP -0.133925007589118 0.000158089768147608 NA NA NA hsa-miR-335-3p SMAD3 1.51116383169018 6.88553098788624e-13 -0.104935015261858 0.513761397736816 mirMAP -0.132872113827048 0.000101143487310671 NA NA NA hsa-miR-335-5p SMAD3 -0.466533891325811 0.0676987038122831 -0.104935015261858 0.513761397736816 miRNAWalker2_validate -0.113837951066797 0.000426295808318841 NA NA NA hsa-miR-146b-5p SMAD4 1.0922867893808 5.63754607494775e-06 -0.515653744933977 9.47137433628545e-06 PITA;miRanda;miRNATAP -0.109392210828109 6.88759131517055e-07 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 0.813513839059142 0.000608282725633232 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate -0.11758126013491 1.55919717084934e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-199a-5p SMAD4 1.3057193856884 2.38429382751645e-08 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.118493107916432 1.4071018929418e-07 NA NA NA hsa-miR-214-5p SMAD4 0.722336234279023 0.00539148054719041 -0.515653744933977 9.47137433628545e-06 MirTarget -0.114669708727048 2.13522290338095e-08 NA NA NA hsa-miR-27a-3p SMAD4 0.433402568013802 0.00737164631768323 -0.515653744933977 9.47137433628545e-06 MirTarget -0.144020279947672 1.5900674575152e-05 NA NA NA hsa-miR-28-5p SMAD4 1.19639196514745 4.59365801666536e-18 -0.515653744933977 9.47137433628545e-06 miRanda;miRNATAP -0.110138329815836 0.00382181011203322 NA NA NA hsa-miR-34a-5p SMAD4 1.40588612517769 8.60097477768592e-12 -0.515653744933977 9.47137433628545e-06 miRNATAP -0.1876322269981 6.61051288734246e-14 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-361-5p SMAD4 0.21454431962475 0.0800957579368424 -0.515653744933977 9.47137433628545e-06 mirMAP -0.157388316044875 0.000434500601175461 NA NA NA hsa-miR-450b-5p SMAD4 1.69248953402469 1.96052058003353e-07 -0.515653744933977 9.47137433628545e-06 mirMAP -0.125104732481319 2.70976048720848e-12 NA NA NA hsa-miR-454-3p SMAD4 1.49453641052169 4.46235742871434e-09 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate;miRNATAP -0.103755273712557 2.90984012875118e-05 NA NA NA hsa-miR-590-5p SMAD4 2.07441240363458 4.95240551694843e-14 -0.515653744933977 9.47137433628545e-06 miRanda -0.127332971579553 5.14267821558811e-08 NA NA NA hsa-miR-103a-3p SMAD7 0.538497806383155 1.88134691850591e-05 -1.03334261220629 1.40098151909512e-11 miRNAWalker2_validate -0.175550659410964 0.00233649911608848 NA NA NA hsa-miR-106a-5p SMAD7 1.3902608059488 6.07931522284525e-05 -1.03334261220629 1.40098151909512e-11 miRNATAP -0.126098371918768 2.91821282197453e-08 NA NA NA hsa-miR-106b-5p SMAD7 1.47447672652218 1.32004094930462e-13 -1.03334261220629 1.40098151909512e-11 miRNATAP -0.20184823937347 6.73156217337974e-09 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-16-5p SMAD7 0.749619098384047 4.11649450706988e-06 -1.03334261220629 1.40098151909512e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.146063396266522 0.000921870129280765 NA NA NA hsa-miR-17-5p SMAD7 2.07078488653279 2.77403038572568e-19 -1.03334261220629 1.40098151909512e-11 TargetScan;miRNATAP -0.165693236232262 2.23894587820285e-08 NA NA NA hsa-miR-182-5p SMAD7 3.21839823004635 5.13049145201115e-39 -1.03334261220629 1.40098151909512e-11 miRNATAP -0.134776563775354 3.86855719428812e-07 NA NA NA hsa-miR-20a-5p SMAD7 2.64649625616975 5.1469418982085e-27 -1.03334261220629 1.40098151909512e-11 miRNATAP -0.134878840462214 8.34150952262662e-07 NA NA NA hsa-miR-21-3p SMAD7 2.54206008030157 1.11598785398763e-30 -1.03334261220629 1.40098151909512e-11 MirTarget -0.116080725615902 0.000135903689078748 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-21-5p SMAD7 4.38165933891779 1.52536633902505e-92 -1.03334261220629 1.40098151909512e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.148016758566167 4.47144478410339e-08 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-25-3p SMAD7 0.361927330834176 0.0163670566170988 -1.03334261220629 1.40098151909512e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.174094723275729 0.000290663619179388 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer colon cancer hsa-miR-590-3p SMAD7 0.83851360565783 0.00129224433453587 -1.03334261220629 1.40098151909512e-11 miRanda -0.165962125119586 3.92730078053594e-07 NA NA NA hsa-miR-590-5p SMAD7 2.07441240363458 4.95240551694843e-14 -1.03334261220629 1.40098151909512e-11 MirTarget;PITA;miRanda;miRNATAP -0.147867429388902 2.34167471315949e-06 NA NA NA hsa-miR-671-5p SMAD7 2.24156654191798 2.10433241567652e-14 -1.03334261220629 1.40098151909512e-11 PITA -0.121342374981944 1.85649329352746e-05 NA NA NA hsa-miR-93-5p SMAD7 1.50844106515467 1.83836866996875e-12 -1.03334261220629 1.40098151909512e-11 miRNATAP -0.18049649492187 2.75705350284284e-08 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-98-5p SMAD7 1.170602085804 1.09900501665229e-08 -1.03334261220629 1.40098151909512e-11 miRNAWalker2_validate -0.152449463959285 1.67406719207547e-05 NA NA NA hsa-miR-107 SNAI2 0.658676029898313 5.11480446318819e-07 -0.554815854836026 0.0572510642413704 miRanda -0.453280671767904 9.47828797287328e-06 NA NA NA hsa-miR-148b-3p SNAI2 0.483970528590224 0.0026495409465901 -0.554815854836026 0.0572510642413704 miRNAWalker2_validate -0.556715968710761 1.39573841121991e-11 NA NA NA hsa-miR-182-5p SNAI2 3.21839823004635 5.13049145201115e-39 -0.554815854836026 0.0572510642413704 miRNAWalker2_validate;miRNATAP -0.27996146293031 1.54370882600273e-08 NA NA NA hsa-miR-200b-3p SNAI2 1.55157578247391 4.83790020897188e-09 -0.554815854836026 0.0572510642413704 TargetScan -0.443484841265163 2.179079103861e-20 NA NA NA hsa-miR-200c-3p SNAI2 0.380533388300368 0.0842181838538353 -0.554815854836026 0.0572510642413704 miRNATAP -0.454021736927152 2.59527605282676e-14 NA NA NA hsa-miR-335-3p SNAI2 1.51116383169018 6.88553098788624e-13 -0.554815854836026 0.0572510642413704 mirMAP -0.277154551162383 8.12434222553235e-06 NA NA NA hsa-miR-375 SNAI2 0.615547997686534 0.149199273675144 -0.554815854836026 0.0572510642413704 miRanda -0.275636396308253 7.67532856156687e-20 NA NA NA hsa-miR-429 SNAI2 2.3794516574089 1.72813419703734e-13 -0.554815854836026 0.0572510642413704 PITA;miRanda;miRNATAP -0.340017457669358 1.60139306581284e-15 NA NA NA hsa-miR-532-5p SNAI2 0.576620898517708 0.0023245812680956 -0.554815854836026 0.0572510642413704 PITA -0.391801913447513 2.51582546466248e-08 NA NA NA hsa-miR-96-5p SNAI2 3.0381097138467 4.40362891630201e-24 -0.554815854836026 0.0572510642413704 miRNATAP -0.265643619461592 4.47304111611125e-08 NA NA NA hsa-miR-139-5p SOX2 -2.26625553116965 7.22375119369519e-16 1.29855541189874 0.0358562574934441 miRanda -0.292392123024581 0.0029394465339055 NA NA NA hsa-miR-140-5p STK3 0.669142684153918 0.000335928403032308 0.196207476667763 0.130742624824556 PITA;miRanda -0.128810906746511 8.08502761316053e-05 NA NA NA hsa-miR-342-3p STK3 -0.128691966564961 0.561034080130801 0.196207476667763 0.130742624824556 miRanda -0.136758532944532 3.28789203417708e-07 NA NA NA hsa-miR-130b-5p TCF7L1 1.53645187062942 1.10498816261505e-08 -0.891121154525344 0.00171182601810095 MirTarget -0.13195811384953 0.0061200745074429 NA NA NA hsa-miR-142-5p TCF7L1 1.29672439149353 4.0768822158894e-06 -0.891121154525344 0.00171182601810095 PITA -0.131361541543027 0.00890316043023296 NA NA NA hsa-miR-590-3p TCF7L1 0.83851360565783 0.00129224433453587 -0.891121154525344 0.00171182601810095 PITA;miRanda;miRNATAP -0.2260698525085 0.000170663252280023 NA NA NA hsa-let-7g-3p TCF7L2 2.38336858943031 4.8771148585792e-17 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.126291442849105 5.3667323482943e-09 NA NA NA hsa-miR-132-3p TCF7L2 0.0122601212105202 0.934032846062939 -0.440319687404722 0.00166470235681049 miRNATAP -0.154343299195605 0.000466067222071514 NA NA NA hsa-miR-155-5p TCF7L2 0.813513839059142 0.000608282725633232 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.174255291736268 6.16077982708104e-11 NA NA NA hsa-miR-183-5p TCF7L2 2.39247234736657 3.92444525331999e-21 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.12984284690733 7.14979721612215e-08 NA NA NA hsa-miR-186-5p TCF7L2 0.852175445703945 6.88885738584309e-10 -0.440319687404722 0.00166470235681049 mirMAP -0.15438674683179 0.000891121529737024 NA NA NA hsa-miR-20a-3p TCF7L2 2.51803599558247 4.92479325298629e-13 -0.440319687404722 0.00166470235681049 MirTarget;miRNATAP -0.125307698569328 5.63624873975403e-08 NA NA NA hsa-miR-24-2-5p TCF7L2 1.43704663046967 4.34375016509278e-11 -0.440319687404722 0.00166470235681049 MirTarget -0.159160974541593 3.05492350459177e-08 NA NA NA hsa-miR-342-3p TCF7L2 -0.128691966564961 0.561034080130801 -0.440319687404722 0.00166470235681049 miRanda -0.183821210156152 1.73100538878158e-10 NA NA NA hsa-miR-542-3p TCF7L2 1.62226640768239 2.6427102465476e-10 -0.440319687404722 0.00166470235681049 miRanda -0.11950359213415 1.05886309370529e-06 NA NA NA hsa-miR-590-3p TCF7L2 0.83851360565783 0.00129224433453587 -0.440319687404722 0.00166470235681049 miRanda -0.119192382595226 5.43448019342063e-05 NA NA NA hsa-miR-942-5p TCF7L2 -0.0372813055050076 0.870631058767894 -0.440319687404722 0.00166470235681049 MirTarget -0.117378020078121 5.00553323457891e-05 NA NA NA hsa-miR-96-5p TCF7L2 3.0381097138467 4.40362891630201e-24 -0.440319687404722 0.00166470235681049 MirTarget;TargetScan;miRNATAP -0.14787544239925 1.79995050445034e-10 NA NA NA hsa-miR-101-5p TEAD1 -0.0265235292039296 0.917878791358577 -0.543294467598958 0.000212724858270988 MirTarget;mirMAP -0.104235472638658 0.00152436692791687 NA NA NA hsa-miR-103a-3p TEAD1 0.538497806383155 1.88134691850591e-05 -0.543294467598958 0.000212724858270988 mirMAP -0.195148486774194 0.000324437596926933 NA NA NA hsa-miR-107 TEAD1 0.658676029898313 5.11480446318819e-07 -0.543294467598958 0.000212724858270988 mirMAP -0.141736673573644 0.00636802941356687 NA NA NA hsa-miR-141-3p TEAD1 3.36993755486106 5.42939251147195e-32 -0.543294467598958 0.000212724858270988 mirMAP -0.1296336000835 2.55745690249664e-09 NA NA NA hsa-miR-148a-3p TEAD1 2.30885799126944 1.95226081368985e-21 -0.543294467598958 0.000212724858270988 MirTarget;miRNATAP -0.140580346298953 1.04409426465317e-07 NA NA NA hsa-miR-148b-3p TEAD1 0.483970528590224 0.0026495409465901 -0.543294467598958 0.000212724858270988 MirTarget -0.248588507174194 2.65479150935503e-09 NA NA NA hsa-miR-17-5p TEAD1 2.07078488653279 2.77403038572568e-19 -0.543294467598958 0.000212724858270988 mirMAP -0.106195536627679 0.000165587425638754 NA NA NA hsa-miR-185-5p TEAD1 1.14291034858482 2.95777119743491e-13 -0.543294467598958 0.000212724858270988 MirTarget;miRNATAP -0.115208404854047 0.00682954803179125 NA NA NA hsa-miR-186-5p TEAD1 0.852175445703945 6.88885738584309e-10 -0.543294467598958 0.000212724858270988 MirTarget -0.237632253016101 9.36354752011349e-07 NA NA NA hsa-miR-200a-3p TEAD1 3.14766878548496 1.32850889777422e-21 -0.543294467598958 0.000212724858270988 mirMAP -0.101872327147822 3.24188747022289e-07 NA NA NA hsa-miR-200c-3p TEAD1 0.380533388300368 0.0842181838538353 -0.543294467598958 0.000212724858270988 miRNATAP -0.190173114121892 3.7478266073536e-10 NA NA NA hsa-miR-20a-5p TEAD1 2.64649625616975 5.1469418982085e-27 -0.543294467598958 0.000212724858270988 mirMAP -0.109892781299034 2.20770241585159e-05 NA NA NA hsa-miR-29b-2-5p TEAD1 0.345881055247341 0.194842633194187 -0.543294467598958 0.000212724858270988 MirTarget -0.13776495334611 4.35171355201177e-08 NA NA NA hsa-miR-29b-3p TEAD1 3.10527711861309 3.01242507282711e-32 -0.543294467598958 0.000212724858270988 mirMAP -0.129959756941325 4.66586523461158e-08 NA NA NA hsa-miR-29c-3p TEAD1 1.32354490728858 1.84279305179762e-07 -0.543294467598958 0.000212724858270988 mirMAP -0.102841695711664 9.25909487817366e-05 NA NA NA hsa-miR-30d-3p TEAD1 0.00396376345349925 0.986457040013182 -0.543294467598958 0.000212724858270988 MirTarget -0.127975228163135 8.45584507547056e-05 NA NA NA hsa-miR-425-5p TEAD1 1.21659524959201 8.01126418494715e-09 -0.543294467598958 0.000212724858270988 mirMAP -0.131491756042077 3.16498530103113e-05 NA NA NA hsa-miR-454-3p TEAD1 1.49453641052169 4.46235742871434e-09 -0.543294467598958 0.000212724858270988 mirMAP -0.116603574849777 0.000194125880520026 NA NA NA hsa-miR-532-5p TEAD1 0.576620898517708 0.0023245812680956 -0.543294467598958 0.000212724858270988 PITA;miRNATAP -0.186804954275461 1.45211414989611e-07 NA NA NA hsa-miR-590-3p TEAD1 0.83851360565783 0.00129224433453587 -0.543294467598958 0.000212724858270988 MirTarget;PITA;miRanda;miRNATAP -0.114483866973965 0.000227304777396013 NA NA NA hsa-miR-664a-3p TEAD1 0.443077463053857 0.0214248925850984 -0.543294467598958 0.000212724858270988 mirMAP -0.173117800838756 7.82695433215649e-07 NA NA NA hsa-miR-93-5p TEAD1 1.50844106515467 1.83836866996875e-12 -0.543294467598958 0.000212724858270988 mirMAP -0.116061727394212 0.000173401145088579 NA NA NA hsa-miR-96-5p TEAD1 3.0381097138467 4.40362891630201e-24 -0.543294467598958 0.000212724858270988 TargetScan;miRNATAP -0.10223692572007 3.36741904785131e-05 NA NA NA hsa-miR-98-5p TEAD1 1.170602085804 1.09900501665229e-08 -0.543294467598958 0.000212724858270988 miRNAWalker2_validate -0.108781179931244 0.00118224729190014 NA NA NA hsa-let-7i-5p TEAD3 0.605080599172936 1.48406814653206e-06 0.339794473170248 0.020009420126378 miRNATAP -0.204534072100885 0.000139225346740193 NA NA NA hsa-miR-181a-5p TEAD4 -0.375429731222937 0.0562142867129802 -0.559351184913488 0.00354279311473138 miRNAWalker2_validate -0.156963133238393 0.000505899444603861 NA NA NA hsa-miR-107 TGFB2 0.658676029898313 5.11480446318819e-07 -1.54728695593794 7.69099073313309e-06 miRanda -0.355503342954706 0.0038910869011085 NA NA NA hsa-miR-141-3p TGFB2 3.36993755486106 5.42939251147195e-32 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.398731446418857 4.7542493450425e-15 NA NA NA hsa-miR-142-3p TGFB2 3.98476449801341 1.56256182021111e-35 -1.54728695593794 7.69099073313309e-06 miRNATAP -0.187445508387807 4.91415161970629e-05 NA NA NA hsa-miR-148a-3p TGFB2 2.30885799126944 1.95226081368985e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.318993015839907 3.72194712163796e-07 NA NA NA hsa-miR-148b-3p TGFB2 0.483970528590224 0.0026495409465901 -1.54728695593794 7.69099073313309e-06 MirTarget -0.597854798049066 1.54973691719479e-09 NA NA NA hsa-miR-186-5p TGFB2 0.852175445703945 6.88885738584309e-10 -1.54728695593794 7.69099073313309e-06 mirMAP -0.409008453141581 0.000403399259315524 NA NA NA hsa-miR-193b-3p TGFB2 1.10444771306846 0.000822888533401377 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.171701127106121 0.000381178774316089 NA NA NA hsa-miR-200a-3p TGFB2 3.14766878548496 1.32850889777422e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.154438122204007 0.00120018739162872 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.06866854356847 0.00389979689199624 -1.54728695593794 7.69099073313309e-06 MirTarget -0.12742735196134 0.0031970050420777 NA NA NA hsa-miR-21-5p TGFB2 4.38165933891779 1.52536633902505e-92 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.232847735640903 0.000134967329541337 NA NA NA hsa-miR-29b-3p TGFB2 3.10527711861309 3.01242507282711e-32 -1.54728695593794 7.69099073313309e-06 miRTarBase;MirTarget;miRNATAP -0.323475743722128 9.24598069519868e-09 NA NA NA hsa-miR-301a-3p TGFB2 2.70198002906399 1.56420889710984e-14 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.16074364225942 0.003487243350105 NA NA NA hsa-miR-324-5p TGFB2 1.06955541886548 5.39722006604758e-05 -1.54728695593794 7.69099073313309e-06 miRanda -0.277999824516596 3.4653275853172e-06 NA NA NA hsa-miR-330-5p TGFB2 0.168520831101569 0.336433937906706 -1.54728695593794 7.69099073313309e-06 miRanda -0.295257890261626 0.00139702498209663 NA NA NA hsa-miR-335-3p TGFB2 1.51116383169018 6.88553098788624e-13 -1.54728695593794 7.69099073313309e-06 mirMAP -0.356021240436402 1.58351764723679e-06 NA NA NA hsa-miR-375 TGFB2 0.615547997686534 0.149199273675144 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.199582093308253 8.10520720431323e-08 NA NA NA hsa-miR-454-3p TGFB2 1.49453641052169 4.46235742871434e-09 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.278722444132023 0.000172215670429774 NA NA NA hsa-miR-589-3p TGFB2 1.34253876396688 1.84935927493927e-05 -1.54728695593794 7.69099073313309e-06 MirTarget -0.136277206270106 0.00952077915925194 NA NA NA hsa-miR-590-3p TGFB2 0.83851360565783 0.00129224433453587 -1.54728695593794 7.69099073313309e-06 mirMAP -0.246860466689251 0.000814615379526392 NA NA NA hsa-miR-590-5p TGFB2 2.07441240363458 4.95240551694843e-14 -1.54728695593794 7.69099073313309e-06 miRanda;miRNATAP -0.326100319483825 3.24920581765168e-06 NA NA NA hsa-miR-151a-5p TGFB3 1.23124135275661 2.93488020257558e-12 -0.422252931437748 0.0394980941232173 MirTarget -0.160744804451189 0.00224479945628548 NA NA NA hsa-miR-181a-5p TGFBR1 -0.375429731222937 0.0562142867129802 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.111893127985776 0.00187864554318442 NA NA NA hsa-miR-181b-5p TGFBR1 0.668793269169928 0.000239998092406404 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.106118594458465 0.00618830848725763 NA NA NA hsa-miR-186-5p TGFBR1 0.852175445703945 6.88885738584309e-10 -0.167191366180853 0.27609922306653 mirMAP -0.186046735019657 0.000240151436081305 NA NA NA hsa-miR-301a-3p TGFBR1 2.70198002906399 1.56420889710984e-14 -0.167191366180853 0.27609922306653 miRNATAP -0.127251998150772 9.77464856526446e-08 NA NA NA hsa-miR-339-5p TGFBR1 0.536997313601114 0.0488090394176611 -0.167191366180853 0.27609922306653 miRanda -0.10996653528395 1.92059453349486e-05 NA NA NA hsa-miR-454-3p TGFBR1 1.49453641052169 4.46235742871434e-09 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.189224937093636 4.08118068619792e-09 NA NA NA hsa-miR-500a-5p TGFBR1 0.648155655714409 0.0104657432932038 -0.167191366180853 0.27609922306653 mirMAP -0.114024018807088 6.20777757370005e-05 NA NA NA hsa-miR-590-5p TGFBR1 2.07441240363458 4.95240551694843e-14 -0.167191366180853 0.27609922306653 PITA;miRanda -0.10044599216345 0.00115082407675084 NA NA NA hsa-miR-664a-3p TGFBR1 0.443077463053857 0.0214248925850984 -0.167191366180853 0.27609922306653 mirMAP -0.121722345860296 0.000910606813958885 NA NA NA hsa-miR-96-5p TGFBR1 3.0381097138467 4.40362891630201e-24 -0.167191366180853 0.27609922306653 TargetScan;miRNATAP -0.122213570914045 1.7309565646113e-06 NA NA NA hsa-miR-106a-5p TGFBR2 1.3902608059488 6.07931522284525e-05 -1.91514811101753 8.06244385153145e-21 miRTarBase;miRNATAP -0.307299619778838 1.05077186229689e-24 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 1.47447672652218 1.32004094930462e-13 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.489829180282667 8.40946965796872e-27 NA NA NA hsa-miR-107 TGFBR2 0.658676029898313 5.11480446318819e-07 -1.91514811101753 8.06244385153145e-21 miRanda;miRNATAP -0.249662024836709 0.000915438458167535 NA NA NA hsa-miR-130a-3p TGFBR2 0.881660100597014 0.000158893668519248 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.133524786080657 0.00147048710917249 NA NA NA hsa-miR-130b-3p TGFBR2 1.83046548750752 5.04753914574694e-13 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.421734905263531 3.34337229820852e-29 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-142-3p TGFBR2 3.98476449801341 1.56256182021111e-35 -1.91514811101753 8.06244385153145e-21 miRanda -0.187481539830466 1.6656456255275e-11 NA NA NA hsa-miR-17-5p TGFBR2 2.07078488653279 2.77403038572568e-19 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.459908602342412 2.77212111529676e-33 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-186-5p TGFBR2 0.852175445703945 6.88885738584309e-10 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.37798394554975 7.20570520945192e-08 NA NA NA hsa-miR-18a-5p TGFBR2 1.37435209536521 9.2173853686829e-06 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate -0.38653356233861 4.47853283994857e-34 NA NA NA hsa-miR-19a-3p TGFBR2 2.11776595911517 7.07663078397156e-10 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.323482765468371 5.08943605092696e-24 NA NA NA hsa-miR-19b-3p TGFBR2 2.10868505662119 5.40846613768389e-17 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.328250904264368 1.63625661417425e-17 NA NA NA hsa-miR-20a-5p TGFBR2 2.64649625616975 5.1469418982085e-27 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.375686915628948 1.07150885156846e-25 NA NA NA hsa-miR-20b-5p TGFBR2 1.35770573270947 0.00260808530013016 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.192278018490753 3.46305290056928e-18 NA NA NA hsa-miR-21-5p TGFBR2 4.38165933891779 1.52536633902505e-92 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.29338269527103 7.25339608661878e-16 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-28-5p TGFBR2 1.19639196514745 4.59365801666536e-18 -1.91514811101753 8.06244385153145e-21 miRanda -0.254315455087218 0.000247518782921618 NA NA NA hsa-miR-301a-3p TGFBR2 2.70198002906399 1.56420889710984e-14 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.306940704751146 1.9075182777364e-21 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320b TGFBR2 0.226640952564488 0.378818692487242 -1.91514811101753 8.06244385153145e-21 miRanda;miRNATAP -0.165151125825337 1.46846956764834e-05 NA NA NA hsa-miR-335-3p TGFBR2 1.51116383169018 6.88553098788624e-13 -1.91514811101753 8.06244385153145e-21 mirMAP -0.311492404920043 3.63496852087191e-12 NA NA NA hsa-miR-429 TGFBR2 2.3794516574089 1.72813419703734e-13 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.181653865770588 1.06914381055553e-08 NA NA NA hsa-miR-454-3p TGFBR2 1.49453641052169 4.46235742871434e-09 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.388080867072043 1.00998271677092e-18 NA NA NA hsa-miR-590-3p TGFBR2 0.83851360565783 0.00129224433453587 -1.91514811101753 8.06244385153145e-21 miRanda -0.298621103008163 1.65211510727765e-11 NA NA NA hsa-miR-590-5p TGFBR2 2.07441240363458 4.95240551694843e-14 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.431767389541112 5.30215312039448e-26 NA NA NA hsa-miR-9-5p TGFBR2 4.99250901331516 2.59132733422801e-19 -1.91514811101753 8.06244385153145e-21 miRNATAP -0.172577947355941 5.13696472146911e-27 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 -0.136362762339122 0.493412263619364 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate -0.23924023089002 1.25343457467846e-06 NA NA NA hsa-miR-93-5p TGFBR2 1.50844106515467 1.83836866996875e-12 -1.91514811101753 8.06244385153145e-21 miRNAWalker2_validate;miRNATAP -0.466353393701927 4.52770573714137e-28 NA NA NA hsa-miR-335-5p TP73 -0.466533891325811 0.0676987038122831 0.747565174453192 0.029826592573533 mirMAP -0.236913481774427 0.000654611579572471 NA NA NA hsa-miR-19a-3p WNT10A 2.11776595911517 7.07663078397156e-10 0.980923245916377 0.0256012470255502 MirTarget -0.208517193720384 0.00257863029042926 NA NA NA hsa-miR-19b-3p WNT10A 2.10868505662119 5.40846613768389e-17 0.980923245916377 0.0256012470255502 MirTarget -0.256769302462553 0.00174324980173983 NA NA NA hsa-miR-335-5p WNT10B -0.466533891325811 0.0676987038122831 1.15088038731375 0.000605834407682622 miRNAWalker2_validate -0.196457776774209 0.00395664338130929 NA NA NA hsa-miR-590-3p WNT11 0.83851360565783 0.00129224433453587 -2.02143786067022 1.52557188447296e-07 miRanda -0.373242513422953 5.34584852988355e-06 NA NA NA hsa-miR-146b-3p WNT16 -0.808296168180355 0.000870284326590347 0.421312581058213 0.381219057601469 MirTarget -0.236129763131591 0.00951773685461053 NA NA NA hsa-miR-181a-5p WNT16 -0.375429731222937 0.0562142867129802 0.421312581058213 0.381219057601469 miRNAWalker2_validate;MirTarget -0.418738717276526 0.000206105344005426 NA NA NA hsa-miR-181b-5p WNT16 0.668793269169928 0.000239998092406404 0.421312581058213 0.381219057601469 MirTarget -0.40294447968335 0.000916083429841582 NA NA NA hsa-miR-338-3p WNT16 0.726843067232002 0.0506251324215494 0.421312581058213 0.381219057601469 miRanda -0.2029582323772 0.00062342767632246 NA NA NA hsa-miR-324-5p WNT2 1.06955541886548 5.39722006604758e-05 -1.62099341554492 1.02036799041017e-06 miRanda -0.225117495213621 9.68444141615679e-05 NA NA NA hsa-miR-335-3p WNT2 1.51116383169018 6.88553098788624e-13 -1.62099341554492 1.02036799041017e-06 mirMAP -0.424763785809356 1.9482456471186e-09 NA NA NA hsa-miR-450b-5p WNT2 1.69248953402469 1.96052058003353e-07 -1.62099341554492 1.02036799041017e-06 miRNATAP -0.136352096158509 0.00934430218904433 NA NA NA hsa-miR-590-3p WNT2 0.83851360565783 0.00129224433453587 -1.62099341554492 1.02036799041017e-06 miRanda;mirMAP -0.196505859855445 0.00563410484574588 NA NA NA hsa-miR-130b-3p WNT2B 1.83046548750752 5.04753914574694e-13 -1.78890659702403 3.23609097451353e-13 MirTarget -0.340760827768826 1.27877889985709e-13 NA NA NA hsa-miR-301a-3p WNT2B 2.70198002906399 1.56420889710984e-14 -1.78890659702403 3.23609097451353e-13 MirTarget -0.180115992461543 5.05894310905406e-06 NA NA NA hsa-miR-454-3p WNT2B 1.49453641052169 4.46235742871434e-09 -1.78890659702403 3.23609097451353e-13 MirTarget -0.194270451419003 0.000290210653240505 NA NA NA hsa-miR-576-5p WNT2B 1.02693643167056 1.14846964470173e-06 -1.78890659702403 3.23609097451353e-13 mirMAP -0.165797705305477 0.00238180132947588 NA NA NA hsa-miR-1-3p WNT3 -1.48412019995919 0.000242034342580425 1.72385836258332 7.02627659505305e-11 MirTarget -0.115978938696651 0.000481856119405777 NA NA NA hsa-miR-146a-5p WNT3 0.684701497250824 0.0105316554224149 1.72385836258332 7.02627659505305e-11 MirTarget -0.180302613220747 0.000145074184388495 NA NA NA hsa-miR-214-3p WNT3 -1.1136198715556 3.52054933799089e-05 1.72385836258332 7.02627659505305e-11 MirTarget -0.180986641633061 7.6059663873487e-05 NA NA NA hsa-miR-215-5p WNT3 0.116505586532384 0.8384722675454 1.72385836258332 7.02627659505305e-11 miRNAWalker2_validate -0.102190911979834 4.37215917167493e-05 NA NA NA hsa-miR-374a-5p WNT3 -0.197027254874826 0.298080902192861 1.72385836258332 7.02627659505305e-11 MirTarget -0.270326406605983 0.000253972455169089 NA NA NA hsa-miR-374b-5p WNT3 0.474691035780475 0.0109217471394203 1.72385836258332 7.02627659505305e-11 MirTarget -0.227038416164753 0.00129354407838489 NA NA NA hsa-miR-107 WNT3A 0.658676029898313 5.11480446318819e-07 -5.44957058224664 2.48610908209879e-25 MirTarget;PITA;miRanda;miRNATAP -0.602191379255807 0.00204464357053535 NA NA NA hsa-miR-128-3p WNT3A 1.03509868349735 2.11606310588315e-10 -5.44957058224664 2.48610908209879e-25 miRNAWalker2_validate -0.728776208229076 2.12961409810896e-06 27341528 AurkA controls self renewal of breast cancer initiating cells promoting wnt3a stabilization through suppression of miR 128; Interestingly we found that AurkA suppressed the expression of miR-128 inhibitor of wnt3a mRNA stabilization breast cancer hsa-miR-331-3p WNT3A 0.648841966086413 0.00576420872256978 -5.44957058224664 2.48610908209879e-25 mirMAP -0.29884516924688 0.00591831494705552 NA NA NA hsa-miR-424-5p WNT3A 1.26485330287919 6.1498991028257e-06 -5.44957058224664 2.48610908209879e-25 MirTarget;miRNATAP -0.297073502202942 0.000997929106475519 NA NA NA hsa-miR-9-5p WNT3A 4.99250901331516 2.59132733422801e-19 -5.44957058224664 2.48610908209879e-25 mirMAP -0.213620822045756 9.54678202540892e-07 NA NA NA hsa-miR-126-5p WNT5A 0.851637714492907 0.000391373420568359 -0.372121221213175 0.193057277928512 mirMAP -0.151248062725371 0.00563235728513554 NA NA NA hsa-miR-141-3p WNT5A 3.36993755486106 5.42939251147195e-32 -0.372121221213175 0.193057277928512 TargetScan -0.125793324099707 0.00331852934102782 NA NA NA hsa-miR-142-3p WNT5A 3.98476449801341 1.56256182021111e-35 -0.372121221213175 0.193057277928512 miRanda -0.115944016531076 0.00223771752270671 NA NA NA hsa-miR-155-5p WNT5A 0.813513839059142 0.000608282725633232 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP -0.143815735512937 0.00936896648272965 NA NA NA hsa-miR-15b-3p WNT5A 0.804736041893915 0.000400279611457186 -0.372121221213175 0.193057277928512 mirMAP -0.27043439598839 7.90998328619875e-06 NA NA NA hsa-miR-16-2-3p WNT5A 0.503964803530872 0.0263648405197492 -0.372121221213175 0.193057277928512 MirTarget;mirMAP -0.373377688750202 1.87980527171712e-09 NA NA NA hsa-miR-16-5p WNT5A 0.749619098384047 4.11649450706988e-06 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.268804385552065 0.000862585179250393 NA NA NA hsa-miR-186-5p WNT5A 0.852175445703945 6.88885738584309e-10 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP;miRNATAP -0.417054301807237 9.65966030008268e-06 NA NA NA hsa-miR-29a-5p WNT5A 1.89519956688438 1.03453349363915e-11 -0.372121221213175 0.193057277928512 mirMAP -0.261183965471408 1.91826113480268e-06 NA NA NA hsa-miR-330-5p WNT5A 0.168520831101569 0.336433937906706 -0.372121221213175 0.193057277928512 miRanda -0.274622273940661 0.000275442864491591 NA NA NA hsa-miR-421 WNT5A 0.170525317701774 0.535277026680289 -0.372121221213175 0.193057277928512 miRanda -0.196624128752936 0.000152464264404546 NA NA NA hsa-miR-576-5p WNT5A 1.02693643167056 1.14846964470173e-06 -0.372121221213175 0.193057277928512 mirMAP -0.395707662531266 7.42053392121266e-11 NA NA NA hsa-miR-582-5p WNT5A 1.08286181406653 0.00149040450161757 -0.372121221213175 0.193057277928512 miRNATAP -0.235280095327202 1.35931910686728e-09 NA NA NA hsa-miR-590-3p WNT5A 0.83851360565783 0.00129224433453587 -0.372121221213175 0.193057277928512 miRanda;mirMAP;miRNATAP -0.160395547617788 0.00800150886159335 NA NA NA hsa-miR-7-1-3p WNT5A 2.61364240402652 1.98959237815786e-32 -0.372121221213175 0.193057277928512 mirMAP -0.239522398062042 4.22941459082507e-05 NA NA NA hsa-miR-92a-3p WNT5A -0.136362762339122 0.493412263619364 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.355450854560077 6.47407085500391e-08 NA NA NA hsa-miR-107 WNT7A 0.658676029898313 5.11480446318819e-07 -4.45137691541241 9.35879470799359e-12 MirTarget;miRanda -1.03715758348073 9.71742260378246e-06 NA NA NA hsa-miR-16-5p WNT7A 0.749619098384047 4.11649450706988e-06 -4.45137691541241 9.35879470799359e-12 MirTarget -0.548666659996717 0.00371402269827223 NA NA NA hsa-miR-424-5p WNT7A 1.26485330287919 6.1498991028257e-06 -4.45137691541241 9.35879470799359e-12 MirTarget -0.285734864631646 0.00887697958116401 NA NA NA hsa-miR-106b-5p WNT7B 1.47447672652218 1.32004094930462e-13 0.452362236585075 0.156970109058151 mirMAP -0.232328578391748 0.00128070505061169 NA NA NA hsa-miR-1226-3p WNT7B -1.00799676115747 0.00514693761539554 0.452362236585075 0.156970109058151 mirMAP -0.160168308487223 0.000759470342513103 NA NA NA hsa-miR-330-5p WNT7B 0.168520831101569 0.336433937906706 0.452362236585075 0.156970109058151 MirTarget;miRanda -0.256154684864363 0.00246766804709769 NA NA NA hsa-miR-335-5p WNT7B -0.466533891325811 0.0676987038122831 0.452362236585075 0.156970109058151 miRNAWalker2_validate -0.24585218224077 0.000133678965329474 NA NA NA hsa-miR-16-5p WNT9A 0.749619098384047 4.11649450706988e-06 -1.70715193650801 1.03413487994031e-08 mirMAP -0.26609532840731 0.00188366377751934 NA NA NA hsa-miR-28-5p WNT9A 1.19639196514745 4.59365801666536e-18 -1.70715193650801 1.03413487994031e-08 mirMAP -0.413487846679742 2.50403745773092e-05 NA NA NA hsa-miR-106b-5p WTIP 1.47447672652218 1.32004094930462e-13 -0.856928783139321 0.00130491225143346 mirMAP -0.370481119643993 4.81177287861166e-10 NA NA NA hsa-miR-148b-5p WTIP 1.39335695292409 2.13220380550073e-07 -0.856928783139321 0.00130491225143346 mirMAP -0.14842689040862 0.00644716307032865 NA NA NA hsa-miR-183-5p WTIP 2.39247234736657 3.92444525331999e-21 -0.856928783139321 0.00130491225143346 mirMAP -0.253955754882819 3.28769153679465e-08 NA NA NA hsa-miR-194-5p WTIP 1.76979641760284 8.2064222072696e-05 -0.856928783139321 0.00130491225143346 mirMAP -0.108651506026952 5.94815496484425e-05 NA NA NA hsa-miR-25-3p WTIP 0.361927330834176 0.0163670566170988 -0.856928783139321 0.00130491225143346 mirMAP -0.33162415981075 5.49140821802059e-05 NA NA NA hsa-miR-320b WTIP 0.226640952564488 0.378818692487242 -0.856928783139321 0.00130491225143346 mirMAP -0.125619226411861 0.00887217214937857 NA NA NA hsa-miR-363-3p WTIP -0.301366430789287 0.414451883803084 -0.856928783139321 0.00130491225143346 mirMAP -0.101059531393673 0.00252205064582338 NA NA NA hsa-miR-425-5p WTIP 1.21659524959201 8.01126418494715e-09 -0.856928783139321 0.00130491225143346 mirMAP -0.193398431536735 0.000789299046923158 NA NA NA hsa-miR-550a-5p WTIP 0.59977150019756 0.0314775340172755 -0.856928783139321 0.00130491225143346 mirMAP -0.156361828108889 0.000400342105451283 NA NA NA hsa-miR-582-3p WTIP 1.70881364237226 1.26508456000083e-06 -0.856928783139321 0.00130491225143346 mirMAP -0.145678025157703 2.21322898300536e-05 NA NA NA hsa-miR-7-5p WTIP 0.343825848926135 0.435063427976906 -0.856928783139321 0.00130491225143346 mirMAP -0.199900302096197 6.5937275554316e-09 NA NA NA hsa-miR-106b-5p WWC1 1.47447672652218 1.32004094930462e-13 -0.862637106674437 1.03990420322894e-06 mirMAP -0.167469365854493 2.99826729676646e-05 NA NA NA hsa-miR-130a-3p WWC1 0.881660100597014 0.000158893668519248 -0.862637106674437 1.03990420322894e-06 mirMAP -0.116694197581353 0.000858232778887909 NA NA NA hsa-miR-130b-3p WWC1 1.83046548750752 5.04753914574694e-13 -0.862637106674437 1.03990420322894e-06 mirMAP -0.228599053734305 2.50539609463112e-12 NA NA NA hsa-miR-143-5p WWC1 1.86670676070774 1.06290100545251e-09 -0.862637106674437 1.03990420322894e-06 mirMAP -0.134711335430106 2.43985314319224e-07 NA NA NA hsa-miR-155-5p WWC1 0.813513839059142 0.000608282725633232 -0.862637106674437 1.03990420322894e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.109854501747356 0.00144858867148122 NA NA NA hsa-miR-17-5p WWC1 2.07078488653279 2.77403038572568e-19 -0.862637106674437 1.03990420322894e-06 mirMAP -0.15616613334451 4.47572388119937e-06 NA NA NA hsa-miR-20a-5p WWC1 2.64649625616975 5.1469418982085e-27 -0.862637106674437 1.03990420322894e-06 mirMAP -0.108072190641449 0.000598657340579979 NA NA NA hsa-miR-421 WWC1 0.170525317701774 0.535277026680289 -0.862637106674437 1.03990420322894e-06 mirMAP -0.106927941173749 0.000992742270425361 NA NA NA hsa-miR-424-5p WWC1 1.26485330287919 6.1498991028257e-06 -0.862637106674437 1.03990420322894e-06 MirTarget;miRNATAP -0.168140300888963 4.69065833065625e-09 NA NA NA hsa-miR-450b-5p WWC1 1.69248953402469 1.96052058003353e-07 -0.862637106674437 1.03990420322894e-06 mirMAP -0.127739239910703 3.93594083963901e-06 NA NA NA hsa-miR-454-3p WWC1 1.49453641052169 4.46235742871434e-09 -0.862637106674437 1.03990420322894e-06 mirMAP -0.128315813330492 0.000724701843620797 NA NA NA hsa-miR-744-3p WWC1 2.07439104592565 3.30645434602132e-12 -0.862637106674437 1.03990420322894e-06 mirMAP -0.158683866972266 2.20990907796019e-09 NA NA NA hsa-miR-93-5p WWC1 1.50844106515467 1.83836866996875e-12 -0.862637106674437 1.03990420322894e-06 mirMAP -0.142727847469889 0.000137908796499417 NA NA NA hsa-miR-130b-5p WWTR1 1.53645187062942 1.10498816261505e-08 -1.19421330072953 2.99679079914059e-10 MirTarget;miRNATAP -0.112510547769051 0.000540818141391021 NA NA NA hsa-miR-141-3p WWTR1 3.36993755486106 5.42939251147195e-32 -1.19421330072953 2.99679079914059e-10 MirTarget;TargetScan;miRNATAP -0.179464020138248 2.95535753199123e-10 NA NA NA hsa-miR-18a-5p WWTR1 1.37435209536521 9.2173853686829e-06 -1.19421330072953 2.99679079914059e-10 miRNAWalker2_validate -0.14387013242293 2.64497574601418e-06 NA NA NA hsa-miR-200a-3p WWTR1 3.14766878548496 1.32850889777422e-21 -1.19421330072953 2.99679079914059e-10 MirTarget;miRNATAP -0.167617965897479 1.04114366405769e-10 NA NA NA hsa-miR-29a-5p WWTR1 1.89519956688438 1.03453349363915e-11 -1.19421330072953 2.99679079914059e-10 mirMAP -0.110303951302814 0.00314638923241842 NA NA NA hsa-miR-29b-3p WWTR1 3.10527711861309 3.01242507282711e-32 -1.19421330072953 2.99679079914059e-10 miRNATAP -0.182313172295902 4.73466642489884e-09 NA NA NA hsa-miR-30b-5p WWTR1 0.358144314839612 0.138026229059594 -1.19421330072953 2.99679079914059e-10 MirTarget;mirMAP -0.105779397324721 0.00417166365204471 NA NA NA hsa-miR-30c-5p WWTR1 -0.327319105755825 0.123595832152687 -1.19421330072953 2.99679079914059e-10 MirTarget;mirMAP -0.163576276752902 9.30511870704894e-05 NA NA NA hsa-miR-30e-5p WWTR1 1.60414100786743 3.78951090573667e-19 -1.19421330072953 2.99679079914059e-10 MirTarget -0.270654178372937 1.05646209290533e-08 NA NA NA hsa-miR-335-3p WWTR1 1.51116383169018 6.88553098788624e-13 -1.19421330072953 2.99679079914059e-10 MirTarget -0.116212388083433 0.00495731496204065 NA NA NA hsa-miR-501-5p WWTR1 0.411357595674671 0.10435288464149 -1.19421330072953 2.99679079914059e-10 mirMAP -0.177522956723771 3.48578531535807e-07 NA NA NA hsa-miR-576-5p WWTR1 1.02693643167056 1.14846964470173e-06 -1.19421330072953 2.99679079914059e-10 MirTarget;mirMAP -0.108040238212989 0.00985728502994485 NA NA NA hsa-miR-664a-3p WWTR1 0.443077463053857 0.0214248925850984 -1.19421330072953 2.99679079914059e-10 MirTarget;mirMAP -0.215445037750116 2.87254886042168e-06 NA NA NA hsa-miR-7-1-3p WWTR1 2.61364240402652 1.98959237815786e-32 -1.19421330072953 2.99679079914059e-10 mirMAP -0.199989530646822 3.73219887089071e-07 NA NA NA hsa-miR-93-3p WWTR1 1.07631808403007 1.63747525692813e-05 -1.19421330072953 2.99679079914059e-10 MirTarget -0.105279316168598 0.00290748213175332 NA NA NA hsa-miR-142-5p YAP1 1.29672439149353 4.0768822158894e-06 -0.397777761977486 0.0194697960255275 mirMAP -0.118901660824082 6.72628258407036e-05 NA NA NA hsa-miR-335-3p YAP1 1.51116383169018 6.88553098788624e-13 -0.397777761977486 0.0194697960255275 mirMAP -0.106828591256632 0.00337413825090021 NA NA NA hsa-miR-361-3p YAP1 0.0988926195529967 0.549128728500555 -0.397777761977486 0.0194697960255275 MirTarget;PITA -0.148607419956969 0.0019419270139913 NA NA NA hsa-miR-375 YAP1 0.615547997686534 0.149199273675144 -0.397777761977486 0.0194697960255275 miRNAWalker2_validate;miRTarBase;miRNATAP -0.11640048700716 1.04025913033832e-10 21856745;27270433;23685355;20226166 miR 375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer; The transcriptional coactivator YAP1 was determined to be a direct target of miR-375; YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells;A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer; Knockdown of YAP1 phenocopied miR-375 overexpression and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375;Overexpression of miR 10a and miR 375 and downregulation of YAP1 in medullary thyroid carcinoma; Expression of the potential downstream targets of miR-375 YAP1 a growth inhibitor and SLC16a2 a transporter of thyroid hormone was down-regulated in the tumors suggesting that miR-375 is a negative regulator of the expression of these genes; Furthermore the growth inhibitor YAP1 is identified as a potential important downstream target of miR-375;MicroRNA 375 targets Hippo signaling effector YAP in liver cancer and inhibits tumor properties; The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA miRNA miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients n=48; As determined by luciferase reporter assay we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP; Furthermore immunoblotting revealed miR-375 suppressed endogenous YAP protein level; miR-375 is an important regulator of YAP oncogene implicating a potential therapeutic role in HCC treatment ;;; lung cancer;prostate cancer;thyroid cancer;liver cancer hsa-miR-484 YAP1 -0.228576985124486 0.244112867390855 -0.397777761977486 0.0194697960255275 PITA;miRNATAP -0.141524902247444 0.000416617275178356 NA NA NA hsa-miR-590-5p YAP1 2.07441240363458 4.95240551694843e-14 -0.397777761977486 0.0194697960255275 MirTarget;PITA;miRanda;miRNATAP -0.175321013508034 2.67428261854258e-07 NA NA NA hsa-miR-7-1-3p YAP1 2.61364240402652 1.98959237815786e-32 -0.397777761977486 0.0194697960255275 mirMAP -0.120152623904939 0.0005854394636906 NA NA NA hsa-miR-146b-5p YWHAE 1.0922867893808 5.63754607494775e-06 -0.162345608104685 0.146274876044794 miRanda -0.111814411639533 8.76763789112146e-08 NA NA NA hsa-miR-155-5p YWHAE 0.813513839059142 0.000608282725633232 -0.162345608104685 0.146274876044794 MirTarget;miRNATAP -0.123012732065191 6.9279077580742e-09 NA NA NA hsa-miR-199a-5p YWHAE 1.3057193856884 2.38429382751645e-08 -0.162345608104685 0.146274876044794 miRanda -0.148964380915099 1.85988470639596e-12 NA NA NA hsa-miR-199b-5p YWHAE 2.13822205171062 4.56262988762436e-15 -0.162345608104685 0.146274876044794 miRanda -0.120520769429681 1.48491231495563e-11 NA NA NA hsa-miR-139-5p YWHAG -2.26625553116965 7.22375119369519e-16 0.440821980058659 0.00101832071918287 MirTarget;PITA;miRanda;miRNATAP -0.127495400492206 1.2727841918362e-09 NA NA NA hsa-miR-140-3p YWHAG -1.11373309124537 8.35257079443689e-14 0.440821980058659 0.00101832071918287 MirTarget;PITA;miRNATAP -0.306652373379445 1.11890284888968e-14 NA NA NA hsa-miR-181a-5p YWHAG -0.375429731222937 0.0562142867129802 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.173505222876932 2.79310441800563e-08 NA NA NA hsa-miR-181c-5p YWHAG 0.529875814537156 0.0125885822998008 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.170024749920434 3.49311586517858e-09 NA NA NA hsa-miR-200a-3p YWHAG 3.14766878548496 1.32850889777422e-21 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.112404756335661 5.04076550847479e-10 NA NA NA hsa-miR-200b-3p YWHAG 1.55157578247391 4.83790020897188e-09 0.440821980058659 0.00101832071918287 MirTarget;TargetScan -0.13160534442703 6.40730407184039e-09 NA NA NA hsa-miR-30a-5p YWHAG -0.924084264430689 0.000762030454634728 0.440821980058659 0.00101832071918287 miRNATAP -0.201085222503192 1.00065004288776e-20 NA NA NA hsa-miR-30b-5p YWHAG 0.358144314839612 0.138026229059594 0.440821980058659 0.00101832071918287 miRNATAP -0.181888404617956 4.18015678029477e-13 NA NA NA hsa-miR-30c-5p YWHAG -0.327319105755825 0.123595832152687 0.440821980058659 0.00101832071918287 miRNATAP -0.253949498332365 1.69959478903248e-19 NA NA NA hsa-miR-30d-5p YWHAG -0.920901858717441 3.50898334321668e-05 0.440821980058659 0.00101832071918287 miRNATAP -0.235001527999773 1.27841332129965e-18 NA NA NA hsa-miR-30e-5p YWHAG 1.60414100786743 3.78951090573667e-19 0.440821980058659 0.00101832071918287 miRNATAP -0.166831106737098 4.41822966338321e-07 NA NA NA hsa-miR-320a YWHAG -0.961144925954715 1.62478794429204e-08 0.440821980058659 0.00101832071918287 PITA;miRanda;miRNATAP -0.138044013407694 0.000124028645415388 NA NA NA hsa-miR-342-3p YWHAG -0.128691966564961 0.561034080130801 0.440821980058659 0.00101832071918287 miRanda -0.112708260763668 5.54327050620456e-05 NA NA NA hsa-miR-361-3p YWHAG 0.0988926195529967 0.549128728500555 0.440821980058659 0.00101832071918287 miRNATAP -0.180828220753678 1.49095137215055e-06 NA NA NA hsa-miR-500a-5p YWHAG 0.648155655714409 0.0104657432932038 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.116956873840769 2.67083784348092e-06 NA NA NA hsa-miR-103a-3p YWHAH 0.538497806383155 1.88134691850591e-05 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate;MirTarget;miRNATAP -0.203453716772227 1.0945341693782e-07 NA NA NA hsa-miR-107 YWHAH 0.658676029898313 5.11480446318819e-07 -0.232507548831896 0.0270772293659851 MirTarget;PITA;miRanda;miRNATAP -0.11083014392296 0.00269449165913979 NA NA NA hsa-miR-186-5p YWHAH 0.852175445703945 6.88885738584309e-10 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate -0.195720652925808 1.17969368044911e-08 NA NA NA hsa-miR-324-5p YWHAH 1.06955541886548 5.39722006604758e-05 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate -0.1101263094924 6.33335452195712e-10 NA NA NA hsa-miR-139-5p YWHAQ -2.26625553116965 7.22375119369519e-16 0.167770822857293 0.149541644649826 MirTarget;PITA;miRanda;miRNATAP -0.125565430539164 3.05602665873019e-12 NA NA NA hsa-miR-145-3p YWHAQ -0.68545633476888 0.000680820366475469 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.172660588094719 2.86041381730263e-11 NA NA NA hsa-miR-15a-5p YWHAQ 1.62575353599172 1.55312121019827e-19 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.103636165558495 0.000288131949373333 NA NA NA hsa-miR-200b-3p YWHAQ 1.55157578247391 4.83790020897188e-09 0.167770822857293 0.149541644649826 TargetScan -0.103114978597469 1.46440567065747e-07 NA NA NA hsa-miR-27a-3p YWHAQ 0.433402568013802 0.00737164631768323 0.167770822857293 0.149541644649826 MirTarget -0.114218331322201 0.000575063051743503 NA NA NA hsa-miR-27b-3p YWHAQ 0.236438984240408 0.12263510345883 0.167770822857293 0.149541644649826 MirTarget -0.127095716424262 0.000300405629060681 NA NA NA hsa-miR-320a YWHAQ -0.961144925954715 1.62478794429204e-08 0.167770822857293 0.149541644649826 MirTarget;PITA;miRanda;miRNATAP -0.170752732171646 2.8347653578931e-08 NA NA NA hsa-miR-497-5p YWHAQ -0.0546347378264729 0.786205564901684 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.243634757664687 1.35163778783183e-21 NA NA NA hsa-let-7b-5p YWHAZ -1.62016148171663 1.56547487335694e-15 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate -0.16430584605795 1.03419318175904e-07 NA NA NA hsa-miR-125a-5p YWHAZ -1.04824536696301 3.97386082850476e-07 0.742048268483137 1.17639688533012e-07 miRanda -0.237020763887747 6.87766229457755e-15 NA NA NA hsa-miR-140-3p YWHAZ -1.11373309124537 8.35257079443689e-14 0.742048268483137 1.17639688533012e-07 MirTarget;PITA;miRNATAP -0.391596646798971 1.8940405019791e-21 NA NA NA hsa-miR-186-5p YWHAZ 0.852175445703945 6.88885738584309e-10 0.742048268483137 1.17639688533012e-07 mirMAP -0.152208595579121 0.00118572329862627 NA NA NA hsa-miR-195-3p YWHAZ -1.33068822339418 6.65427393047357e-09 0.742048268483137 1.17639688533012e-07 MirTarget -0.222495897728137 3.41482438203482e-16 NA NA NA hsa-miR-30a-5p YWHAZ -0.924084264430689 0.000762030454634728 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.201186598647973 1.15722338635181e-18 NA NA NA hsa-miR-30c-5p YWHAZ -0.327319105755825 0.123595832152687 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.288739774257498 9.48887811222695e-23 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30d-5p YWHAZ -0.920901858717441 3.50898334321668e-05 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.141642518231123 9.75824254047956e-07 NA NA NA hsa-miR-30e-5p YWHAZ 1.60414100786743 3.78951090573667e-19 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.121458978508407 0.000533900032886707 NA NA NA hsa-miR-320a YWHAZ -0.961144925954715 1.62478794429204e-08 0.742048268483137 1.17639688533012e-07 MirTarget;PITA;miRanda;miRNATAP -0.157423933177928 3.20781580410077e-05 NA NA NA hsa-miR-328-3p YWHAZ -0.971820898675371 0.000667255504710486 0.742048268483137 1.17639688533012e-07 MirTarget -0.124104498406864 3.32290942379795e-08 NA NA NA hsa-miR-484 YWHAZ -0.228576985124486 0.244112867390855 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate -0.116171758391268 0.000497835813356803 NA NA NA hsa-miR-664a-3p YWHAZ 0.443077463053857 0.0214248925850984 0.742048268483137 1.17639688533012e-07 mirMAP -0.262638767629816 1.83967801674611e-15 NA NA NA