miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-221-5p ABCG4 1.88626894114756 8.2644671350768e-08 -0.677570068187836 0.193214821758635 MirTarget -0.248209382908306 0.0238189851628485 NA NA NA hsa-miR-221-5p ADCY1 1.88626894114756 8.2644671350768e-08 -1.66799334140719 0.000254731678109537 mirMAP -0.225987926269 0.0205423761883312 NA NA NA hsa-miR-221-5p APC2 1.88626894114756 8.2644671350768e-08 -1.50664575100959 0.000134622121604578 mirMAP -0.343003530849754 3.79548142088197e-05 NA NA NA hsa-miR-221-5p AR 1.88626894114756 8.2644671350768e-08 -3.70084749826932 6.34241879727854e-11 mirMAP -0.440881039789677 0.000402624574786562 23770851;25846647 Overexpressing of miR-221 in LNCaP reduced the transcription of a subgroup of androgen-responsive genes without affecting the androgen receptor AR or AR-androgen integrity; We hypothesize that a major biological consequence of upregulation of miR-221 is reprogramming of AR signaling which in turn may mediate the transition to the CRPC phenotype;Unexpectedly it was found that treatment with the AR agonists resulted in the repression of miR-221 a miRNA previously established to be involved with prostate cancer development ; prostate cancer;prostate cancer hsa-miR-221-5p BSN 1.88626894114756 8.2644671350768e-08 -1.41530985939443 0.00148345797057983 MirTarget;miRNATAP -0.189909608499365 0.0456975925884889 NA NA NA hsa-miR-221-5p CDC42BPA 1.88626894114756 8.2644671350768e-08 -0.973996899365979 0.000595587817030523 MirTarget -0.144599042689168 0.0166633560081663 NA NA NA hsa-miR-221-5p CGNL1 1.88626894114756 8.2644671350768e-08 -3.60656788747399 4.87489976406635e-11 mirMAP -0.348037975303041 0.00415885548164365 NA NA NA hsa-miR-221-5p CHAD 1.88626894114756 8.2644671350768e-08 -3.17249824269304 6.07283300839428e-08 MirTarget -0.266127558467873 0.0377506333594427 NA NA NA hsa-miR-221-5p CHD5 1.88626894114756 8.2644671350768e-08 -2.96603114775526 0.000120569092657154 mirMAP -0.416313720995153 0.0117664132806264 NA NA NA hsa-miR-221-5p CNTN2 1.88626894114756 8.2644671350768e-08 -3.32955880464376 3.72952708501777e-07 mirMAP -0.577107054959784 3.94058922705995e-05 NA NA NA hsa-miR-221-5p CRY2 1.88626894114756 8.2644671350768e-08 -1.7227402083933 3.48090191139846e-18 mirMAP -0.179523472597737 6.4617614006543e-05 NA NA NA hsa-miR-221-5p CYS1 1.88626894114756 8.2644671350768e-08 -1.55216874156308 0.00222794258504041 mirMAP -0.322011581627988 0.00275487354562525 NA NA NA hsa-miR-221-5p DPYSL5 1.88626894114756 8.2644671350768e-08 -0.460592254054383 0.580213594659607 mirMAP;miRNATAP -0.498664620372647 0.00432281880557084 NA NA NA hsa-miR-221-5p FBXL7 1.88626894114756 8.2644671350768e-08 -1.31814012517318 0.000377931874124759 MirTarget -0.18055736295205 0.0226353516546074 NA NA NA hsa-miR-221-5p FGF9 1.88626894114756 8.2644671350768e-08 -1.74987286650449 0.0113341158170243 miRNATAP -0.32184581009566 0.0282949300021691 NA NA NA hsa-miR-221-5p FYCO1 1.88626894114756 8.2644671350768e-08 -1.5179401325491 1.80856813162873e-10 mirMAP -0.189992988596122 0.000257261187875479 NA NA NA hsa-miR-221-5p GAS7 1.88626894114756 8.2644671350768e-08 -1.48493282360108 0.00111662958166612 mirMAP -0.241698042029095 0.0127286479972079 NA NA NA hsa-miR-221-5p GFRA1 1.88626894114756 8.2644671350768e-08 -4.28749759812963 4.8568779979495e-09 MirTarget -0.467136265466894 0.00358897847548142 NA NA NA hsa-miR-221-5p GNAO1 1.88626894114756 8.2644671350768e-08 -2.53860718379486 1.19355845093505e-06 mirMAP -0.387742465946182 0.000559074986176232 NA NA NA hsa-miR-221-5p GPC6 1.88626894114756 8.2644671350768e-08 -1.0388823464409 0.0475589202410226 MirTarget -0.36610864087617 0.000878914504851292 NA NA NA hsa-miR-221-5p GRIK2 1.88626894114756 8.2644671350768e-08 -2.17472850153613 0.00296912453422373 miRNATAP -0.399090504077914 0.0103135666944976 NA NA NA hsa-miR-221-5p GRIK3 1.88626894114756 8.2644671350768e-08 -5.07032861706618 2.36175735334982e-09 MirTarget -0.864243881196595 2.32832080452039e-06 NA NA NA hsa-miR-221-5p HEG1 1.88626894114756 8.2644671350768e-08 -0.157527890873429 0.641105190493804 mirMAP -0.159890878552441 0.0243804743898948 NA NA NA hsa-miR-221-5p HOXA4 1.88626894114756 8.2644671350768e-08 -0.15090691484049 0.706349579598512 miRNATAP -0.210051661227942 0.0125186094119904 NA NA NA hsa-miR-221-5p HPCAL4 1.88626894114756 8.2644671350768e-08 -3.10901027796253 3.25524290200024e-06 MirTarget;miRNATAP -0.324165116367219 0.0249659641285225 NA NA NA hsa-miR-221-5p IGFBP5 1.88626894114756 8.2644671350768e-08 -2.20943041227776 1.46856267574422e-06 mirMAP;miRNATAP -0.370314452922494 0.00016414899105293 NA NA NA hsa-miR-221-5p ITPKB 1.88626894114756 8.2644671350768e-08 -0.804101645446653 0.00554728683039415 mirMAP -0.248756836608213 3.97998604058872e-05 NA NA NA hsa-miR-221-5p JAM3 1.88626894114756 8.2644671350768e-08 -1.45600073086976 1.77559941086938e-05 mirMAP -0.232446641121278 0.00134687585066443 NA NA NA hsa-miR-221-5p KCNA6 1.88626894114756 8.2644671350768e-08 -2.22470041532817 0.000973529237827806 mirMAP -0.567597492565185 6.41419679845799e-05 NA NA NA hsa-miR-221-5p KCNIP3 1.88626894114756 8.2644671350768e-08 -1.41074097822612 0.00207013278727502 MirTarget -0.204535109963401 0.036166339432096 NA NA NA hsa-miR-221-5p KCNK3 1.88626894114756 8.2644671350768e-08 -2.78278194254872 7.48510921135081e-07 mirMAP -0.443433053941529 0.000241875464527872 NA NA NA hsa-miR-221-5p KCTD15 1.88626894114756 8.2644671350768e-08 -0.407194103178091 0.372167872607488 MirTarget -0.226325315099991 0.0184312743036112 NA NA NA hsa-miR-221-5p KIAA1614 1.88626894114756 8.2644671350768e-08 -0.756587001808951 0.0391812834565272 mirMAP -0.228147196242693 0.00311508390275123 NA NA NA hsa-miR-221-5p KIF1C 1.88626894114756 8.2644671350768e-08 -1.17351791103394 1.51837791574188e-08 miRNATAP -0.125114666389687 0.00548074013759564 NA NA NA hsa-miR-221-5p LPP 1.88626894114756 8.2644671350768e-08 -0.861721562656118 0.000304984689206046 mirMAP -0.128118439746369 0.0116271540760121 NA NA NA hsa-miR-221-5p LTBP4 1.88626894114756 8.2644671350768e-08 -1.56952923920785 1.33831274553803e-07 mirMAP -0.2444970883754 0.000132078473979932 NA NA NA hsa-miR-221-5p MAOA 1.88626894114756 8.2644671350768e-08 -1.88092375639075 3.81137351365158e-05 MirTarget -0.231780443715927 0.0181662381957904 NA NA NA hsa-miR-221-5p MAP3K3 1.88626894114756 8.2644671350768e-08 -0.635113788094134 0.000172463517599492 mirMAP -0.110900653752184 0.00188765931502394 NA NA NA hsa-miR-221-5p MAPK8IP1 1.88626894114756 8.2644671350768e-08 -1.25485241287806 0.000960005281863818 MirTarget -0.164465463185599 0.0426332273289253 NA NA NA hsa-miR-221-5p MDGA1 1.88626894114756 8.2644671350768e-08 -0.912045535502726 0.149399246016373 mirMAP -0.331544879801569 0.0129080404304694 NA NA NA hsa-miR-221-5p METRN 1.88626894114756 8.2644671350768e-08 -0.755589560477457 0.0412149116723484 mirMAP -0.163597924592524 0.036676012468603 NA NA NA hsa-miR-221-5p MPP2 1.88626894114756 8.2644671350768e-08 -1.68962844291701 0.00150609837088874 mirMAP -0.342621128251971 0.00240807183921154 NA NA NA hsa-miR-221-5p MXD4 1.88626894114756 8.2644671350768e-08 -0.83631669677805 8.26219680556537e-05 mirMAP -0.117149308859367 0.00965047641339322 NA NA NA hsa-miR-221-5p MXRA7 1.88626894114756 8.2644671350768e-08 -0.49420117015992 0.155062303664449 mirMAP -0.154689121878547 0.0348114817086048 NA NA NA hsa-miR-221-5p NFASC 1.88626894114756 8.2644671350768e-08 -1.62491616946905 0.00154173821715692 mirMAP -0.300782805954473 0.00579899449487489 NA NA NA hsa-miR-221-5p NFIC 1.88626894114756 8.2644671350768e-08 -1.52356093609244 2.75628179121333e-10 mirMAP -0.184274813095268 0.000476049486353664 NA NA NA hsa-miR-221-5p NFIX 1.88626894114756 8.2644671350768e-08 -1.28871427843931 3.51409476801175e-07 mirMAP -0.140970836812662 0.0100138393126418 NA NA NA hsa-miR-221-5p NOX5 1.88626894114756 8.2644671350768e-08 -1.30038550068819 0.0884199319522674 mirMAP -0.538352787150333 0.000767437024749293 NA NA NA hsa-miR-221-5p NPTX1 1.88626894114756 8.2644671350768e-08 -2.20950701088603 0.00675079304146414 mirMAP -0.52662392289048 0.00225809736972371 NA NA NA hsa-miR-221-5p NTN1 1.88626894114756 8.2644671350768e-08 -2.24760329117454 2.59032832653537e-05 mirMAP;miRNATAP -0.322210082656554 0.00492801156193662 NA NA NA hsa-miR-221-5p PDE4D 1.88626894114756 8.2644671350768e-08 -1.47927917004945 9.68576602640868e-07 miRNATAP -0.154174442163329 0.0183263687227555 NA NA NA hsa-miR-221-5p PLEKHO2 1.88626894114756 8.2644671350768e-08 -0.473610334098273 0.0395652649361335 MirTarget -0.122253847240165 0.0115168552528797 NA NA NA hsa-miR-221-5p PLIN4 1.88626894114756 8.2644671350768e-08 -3.91548530270106 8.95955452691386e-11 mirMAP -0.624936977801998 1.85757495183576e-06 NA NA NA hsa-miR-221-5p PLXDC2 1.88626894114756 8.2644671350768e-08 -0.0556786359323107 0.896719262038618 MirTarget -0.219976993555843 0.0146483476803147 NA NA NA hsa-miR-221-5p PPM1M 1.88626894114756 8.2644671350768e-08 -0.527372148625479 0.0129216712827247 MirTarget -0.116883813101374 0.00885176104263932 NA NA NA hsa-miR-221-5p PRICKLE2 1.88626894114756 8.2644671350768e-08 -2.15392418538903 8.11983846689151e-08 MirTarget -0.304830117270056 0.000442965213395619 NA NA NA hsa-miR-221-5p PSKH1 1.88626894114756 8.2644671350768e-08 -0.888695513601794 1.14012166710622e-06 mirMAP -0.114509801503012 0.00343943553412371 NA NA NA hsa-miR-221-5p PTCHD1 1.88626894114756 8.2644671350768e-08 -3.45179867429394 2.82418739742613e-07 mirMAP -0.489981404070082 0.000737715003518234 NA NA NA hsa-miR-221-5p PTPRT 1.88626894114756 8.2644671350768e-08 -2.48614399477185 0.00681414090636231 mirMAP -0.533958253131163 0.00610230333249613 NA NA NA hsa-miR-221-5p RADIL 1.88626894114756 8.2644671350768e-08 -1.72692774150985 0.00413838421802457 mirMAP -0.336709387196833 0.00842948401933634 NA NA NA hsa-miR-221-5p RIC3 1.88626894114756 8.2644671350768e-08 -3.57572485939391 1.34920972028311e-06 MirTarget -0.380174273894283 0.0177793148052799 NA NA NA hsa-miR-221-5p RIMS4 1.88626894114756 8.2644671350768e-08 -4.72303180287896 4.5357789555726e-09 mirMAP -0.513664870001224 0.00359282847183082 NA NA NA hsa-miR-221-5p RPL15 1.88626894114756 8.2644671350768e-08 -0.447416155567419 0.00618572340546406 miRNAWalker2_validate -0.102778451471052 0.002655801375029 NA NA NA hsa-miR-221-5p RUNX1T1 1.88626894114756 8.2644671350768e-08 -1.53600284520788 0.00256737042480342 miRNATAP -0.416090123035725 0.000101741404191531 NA NA NA hsa-miR-221-5p SDC2 1.88626894114756 8.2644671350768e-08 -0.906152496254991 0.0124240335723858 MirTarget -0.238097003761398 0.00181741280656069 NA NA NA hsa-miR-221-5p SIX5 1.88626894114756 8.2644671350768e-08 -0.153734561883233 0.494491486590046 mirMAP -0.137539717790935 0.00339006406409628 NA NA NA hsa-miR-221-5p SLC8A1 1.88626894114756 8.2644671350768e-08 -0.896057943773805 0.0143053049963851 MirTarget -0.166607717955785 0.0316574121711347 NA NA NA hsa-miR-221-5p SORCS1 1.88626894114756 8.2644671350768e-08 -5.181197214611 3.52948817503942e-10 MirTarget;miRNATAP -0.832424919939956 3.29098525437188e-06 NA NA NA hsa-miR-221-5p SORCS2 1.88626894114756 8.2644671350768e-08 -0.900128090696369 0.125994127979436 mirMAP -0.339009405426661 0.00618163152886674 NA NA NA hsa-miR-221-5p SOX12 1.88626894114756 8.2644671350768e-08 0.771847569144892 0.00822867030900978 miRNATAP -0.177785673646194 0.00390916918601102 NA NA NA hsa-miR-221-5p SYNGR1 1.88626894114756 8.2644671350768e-08 -2.0472529782632 0.000265298238533228 mirMAP -0.284414444936116 0.0178759373330477 NA NA NA hsa-miR-221-5p THRB 1.88626894114756 8.2644671350768e-08 -2.40958153867815 2.68173120435323e-06 mirMAP -0.366196292275955 0.00089623134447687 NA NA NA hsa-miR-221-5p TMEM63C 1.88626894114756 8.2644671350768e-08 -0.766295671451477 0.415125735230907 mirMAP -0.465568180826483 0.0187639696419626 NA NA NA hsa-miR-221-5p TMOD1 1.88626894114756 8.2644671350768e-08 -2.88443253310149 9.64902415765915e-10 MirTarget -0.523855307262204 2.2642305360729e-07 NA NA NA hsa-miR-221-5p TRIL 1.88626894114756 8.2644671350768e-08 -0.0135918400289601 0.975649842529798 MirTarget -0.251092194184059 0.00718846351594705 NA NA NA hsa-miR-221-5p UBE2QL1 1.88626894114756 8.2644671350768e-08 -2.74384882830585 1.36371480366871e-05 MirTarget -0.359488822526771 0.00807290645957745 NA NA NA hsa-miR-221-5p ZCCHC24 1.88626894114756 8.2644671350768e-08 -1.65855598693501 1.95998076677745e-06 mirMAP -0.305650306555718 3.8698656312283e-05 NA NA NA hsa-miR-221-5p ZHX3 1.88626894114756 8.2644671350768e-08 -1.41835563638574 4.68701430672901e-12 mirMAP -0.211069725703697 2.22051142417855e-06 NA NA NA