miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-425-5p ADARB1 0.0936889263324847 0.932870183198261 -0.0322745559781419 0.95214549327251 mirMAP -0.283065249825669 1.17017811580193e-10 NA NA NA hsa-miR-425-5p AFF2 0.0936889263324847 0.932870183198261 -0.297630330250078 0.560962391193889 miRNATAP -0.47392197530194 3.38057076566502e-05 NA NA NA hsa-miR-425-5p AMPH 0.0936889263324847 0.932870183198261 0.0773622635950866 0.811243129361095 MirTarget;miRNATAP -0.664813266623668 2.61846230003399e-12 NA NA NA hsa-miR-425-5p ANTXR1 0.0936889263324847 0.932870183198261 -0.0458362816479987 0.962654408365301 MirTarget -0.814242922004579 1.96051460642592e-17 NA NA NA hsa-miR-425-5p BCAT1 0.0936889263324847 0.932870183198261 0.278125072694851 0.588366914213911 MirTarget -0.610715760614027 4.16210490140772e-14 NA NA NA hsa-miR-425-5p BEX4 0.0936889263324847 0.932870183198261 0.246946156777166 0.594579294117156 miRNAWalker2_validate;MirTarget -0.401276736162793 7.22448280733229e-07 NA NA NA hsa-miR-425-5p C3orf70 0.0936889263324847 0.932870183198261 -0.00575055773344646 0.990840549718386 miRNATAP -0.231616824805085 0.00676939237424626 NA NA NA hsa-miR-425-5p CACNA1E 0.0936889263324847 0.932870183198261 0.155495473250271 0.743575257476855 mirMAP -0.545425296608196 2.13370188447364e-05 NA NA NA hsa-miR-425-5p CBX6 0.0936889263324847 0.932870183198261 -0.234439921918545 0.663380200056587 miRNATAP -0.483243198735653 1.13385164414614e-08 NA NA NA hsa-miR-425-5p CFL2 0.0936889263324847 0.932870183198261 -0.00429221099212107 0.993302086631373 miRNATAP -0.481282676078036 4.27033086804076e-18 NA NA NA hsa-miR-425-5p CHL1 0.0936889263324847 0.932870183198261 -0.21473791421855 0.62739270601731 mirMAP -0.833105647245856 8.22340179663411e-11 NA NA NA hsa-miR-425-5p CLU 0.0936889263324847 0.932870183198261 -0.341193320003712 0.688175560706107 miRNAWalker2_validate -0.639147400647713 3.67611891506296e-10 NA NA NA hsa-miR-425-5p CNTN2 0.0936889263324847 0.932870183198261 -0.401215497768751 0.512369809376981 mirMAP -0.759981747422028 2.38283969660205e-09 NA NA NA hsa-miR-425-5p CYGB 0.0936889263324847 0.932870183198261 0.0250477482659086 0.967757472250845 MirTarget -0.261177995487946 3.04969364735844e-06 NA NA NA hsa-miR-425-5p CYYR1 0.0936889263324847 0.932870183198261 -0.00670427705272703 0.986759320844033 MirTarget -0.420216545917722 3.90873828792554e-14 NA NA NA hsa-miR-425-5p DIP2C 0.0936889263324847 0.932870183198261 -0.0949749001567368 0.875961791621318 MirTarget;miRNATAP -0.37917308411408 2.11301445669096e-10 NA NA NA hsa-miR-425-5p DPYSL2 0.0936889263324847 0.932870183198261 -0.209751755269795 0.815776309449995 miRNAWalker2_validate -0.238027663357297 0.000443765743582536 NA NA NA hsa-miR-425-5p DTNA 0.0936889263324847 0.932870183198261 -0.133702097680304 0.771524870282741 mirMAP -0.713598030497373 3.5610318780662e-08 NA NA NA hsa-miR-425-5p EDIL3 0.0936889263324847 0.932870183198261 -0.205206108375255 0.687861880467756 MirTarget -0.68479893327319 7.90192256992065e-13 NA NA NA hsa-miR-425-5p ERC1 0.0936889263324847 0.932870183198261 -0.139712183513244 0.859760969823941 mirMAP -0.117587949967327 0.000414689936303221 NA NA NA hsa-miR-425-5p FKBP1B 0.0936889263324847 0.932870183198261 0.0514829063539158 0.878389080811961 miRNATAP -0.254982056813924 0.00967173771002244 NA NA NA hsa-miR-425-5p FOSL2 0.0936889263324847 0.932870183198261 -0.167760426341187 0.854722265438954 mirMAP -0.183622186624599 3.2672771860644e-05 NA NA NA hsa-miR-425-5p FOXN3 0.0936889263324847 0.932870183198261 -0.187345743000236 0.822379360013315 miRNATAP -0.169130925743894 4.65555472337259e-05 NA NA NA hsa-miR-425-5p FST 0.0936889263324847 0.932870183198261 0.241735455604809 0.478175258443777 MirTarget -0.80329186889095 3.83530048210964e-16 NA NA NA hsa-miR-425-5p GNB5 0.0936889263324847 0.932870183198261 0.00106399671540069 0.998379843805383 miRNAWalker2_validate -0.286665566892633 4.13300378904745e-08 NA NA NA hsa-miR-425-5p GREB1 0.0936889263324847 0.932870183198261 0.113032081285084 0.680150762551301 MirTarget -0.42950878829228 1.14474209713716e-07 NA NA NA hsa-miR-425-5p HHIP 0.0936889263324847 0.932870183198261 -0.122048303818221 0.78184078644314 mirMAP -0.484117162094881 0.000424713790716386 NA NA NA hsa-miR-425-5p HSPB8 0.0936889263324847 0.932870183198261 -0.115489782100452 0.822216726359654 MirTarget -0.939771265258893 5.83199818731545e-23 NA NA NA hsa-miR-425-5p IGSF1 0.0936889263324847 0.932870183198261 0.639429828390335 0.26329963186534 miRNAWalker2_validate -0.314662277178524 0.0329864833622104 NA NA NA hsa-miR-425-5p IL18BP 0.0936889263324847 0.932870183198261 0.135430283087641 0.802924246502802 MirTarget -0.305951599048773 8.18745603703155e-09 NA NA NA hsa-miR-425-5p ITGB3 0.0936889263324847 0.932870183198261 -0.207306852635047 0.627019348924388 MirTarget -0.614251909704281 8.64762548208889e-16 NA NA NA hsa-miR-425-5p ITPR1 0.0936889263324847 0.932870183198261 -0.106850284601967 0.840818735260904 MirTarget;miRNATAP -0.457519160719506 2.94259705715632e-12 NA NA NA hsa-miR-425-5p KCTD15 0.0936889263324847 0.932870183198261 -0.278038853382079 0.624947926156148 mirMAP -0.387567439270147 3.05485707344251e-08 NA NA NA hsa-miR-425-5p KIAA0513 0.0936889263324847 0.932870183198261 -0.00108010418677162 0.998487979961357 mirMAP -0.154921118292524 0.023988336308006 NA NA NA hsa-miR-425-5p KIAA1024 0.0936889263324847 0.932870183198261 -0.17226704727765 0.44279518953284 mirMAP -0.161043553464867 0.012513844630518 NA NA NA hsa-miR-425-5p KIAA1614 0.0936889263324847 0.932870183198261 0.173495396372283 0.412391663681536 mirMAP -0.383845547443315 1.96271913461088e-10 NA NA NA hsa-miR-425-5p KIAA2022 0.0936889263324847 0.932870183198261 -0.291832207363993 0.59570478921045 miRNATAP -1.00264106254625 8.83361680992817e-17 NA NA NA hsa-miR-425-5p KIF1A 0.0936889263324847 0.932870183198261 -0.450319331834301 0.401830141178473 mirMAP -0.881785517608357 1.26123002971538e-08 NA NA NA hsa-miR-425-5p KLHL13 0.0936889263324847 0.932870183198261 0.395625887546888 0.393231805158916 MirTarget;miRNATAP -0.32442563149167 0.0166036619451331 NA NA NA hsa-miR-425-5p LCOR 0.0936889263324847 0.932870183198261 -0.386643541990535 0.34300814994093 miRNAWalker2_validate -0.157307861830175 0.00346387677240356 NA NA NA hsa-miR-425-5p LDOC1L 0.0936889263324847 0.932870183198261 -0.180286947721054 0.812173998453042 MirTarget;mirMAP -0.119963529567006 0.00011367240174753 NA NA NA hsa-miR-425-5p LONRF2 0.0936889263324847 0.932870183198261 -0.451177390204843 0.436633177312587 mirMAP -1.4072901628148 6.54291372148727e-21 NA NA NA hsa-miR-425-5p LRRC15 0.0936889263324847 0.932870183198261 -0.119021821649843 0.845762227795933 mirMAP -0.648864073972254 2.80971762951372e-08 NA NA NA hsa-miR-425-5p MAN1C1 0.0936889263324847 0.932870183198261 -0.206342801917055 0.629705334589721 MirTarget -0.483580140883657 2.16310293023393e-09 NA NA NA hsa-miR-425-5p MBP 0.0936889263324847 0.932870183198261 -0.187919884032891 0.807091594014972 mirMAP -0.109319298538309 0.00606566414328779 NA NA NA hsa-miR-425-5p MEF2C 0.0936889263324847 0.932870183198261 -0.108794595474888 0.836482653958069 MirTarget;miRNATAP -0.436462665567055 1.72670814809168e-11 NA NA NA hsa-miR-425-5p N4BP3 0.0936889263324847 0.932870183198261 0.0106722513031174 0.977543614965485 mirMAP -0.341777948837558 3.53625891751783e-09 NA NA NA hsa-miR-425-5p NAT8L 0.0936889263324847 0.932870183198261 0.15280492920204 0.751089588886392 mirMAP -0.318615533805011 0.00592967881456327 NA NA NA hsa-miR-425-5p NCAM1 0.0936889263324847 0.932870183198261 -0.574260478901192 0.160141043900101 miRNATAP -0.529293258071001 1.72210165970266e-06 NA NA NA hsa-miR-425-5p NCF2 0.0936889263324847 0.932870183198261 0.268839693721667 0.616773340287636 MirTarget -0.542082055669823 7.13813353706896e-09 NA NA NA hsa-miR-425-5p NECAB1 0.0936889263324847 0.932870183198261 0.0961453664098196 0.74917534119463 MirTarget -0.722111380276361 1.36478978879315e-18 NA NA NA hsa-miR-425-5p NOS1 0.0936889263324847 0.932870183198261 0.349915523028596 0.623787646446415 mirMAP -1.01179092518329 2.65483648191115e-13 NA NA NA hsa-miR-425-5p NOVA2 0.0936889263324847 0.932870183198261 0.114321192004282 0.568416565890151 mirMAP -0.309523737676617 7.49315278417986e-08 NA NA NA hsa-miR-425-5p NRIP3 0.0936889263324847 0.932870183198261 0.152878468438377 0.540988970072054 MirTarget -0.316258579797859 5.96582717699814e-06 NA NA NA hsa-miR-425-5p OSBPL8 0.0936889263324847 0.932870183198261 0.0195668959503204 0.980698674831994 miRNATAP -0.111530496696219 0.000840191403016413 NA NA NA hsa-miR-425-5p PAFAH1B1 0.0936889263324847 0.932870183198261 -0.0888063647313881 0.926212181252073 MirTarget;miRNATAP -0.136459543430829 5.32419609829386e-08 NA NA NA hsa-miR-425-5p PCDHB5 0.0936889263324847 0.932870183198261 -0.0250883343606751 0.929984218179197 MirTarget -0.647084779506458 6.48273344365465e-16 NA NA NA hsa-miR-425-5p PDE4A 0.0936889263324847 0.932870183198261 -0.30042566877123 0.67023636188809 miRNATAP -0.128266819535689 0.0060002692179569 NA NA NA hsa-miR-425-5p PHF21A 0.0936889263324847 0.932870183198261 -0.0412311069151468 0.95023216383583 MirTarget -0.144692801650875 3.87567155871494e-08 NA NA NA hsa-miR-425-5p PIP4K2A 0.0936889263324847 0.932870183198261 0.070791816192588 0.913983434591933 miRNAWalker2_validate -0.210665651203123 3.34371243127712e-10 NA NA NA hsa-miR-425-5p PNMAL1 0.0936889263324847 0.932870183198261 0.0926900617342266 0.807827467883158 MirTarget -0.816024873556326 3.97052643513794e-13 NA NA NA hsa-miR-425-5p PPM1L 0.0936889263324847 0.932870183198261 -0.397694877863214 0.17049525193962 MirTarget -0.154175697833971 0.00629344498500602 NA NA NA hsa-miR-425-5p PSD3 0.0936889263324847 0.932870183198261 -0.0900363733363951 0.891460059694351 mirMAP -0.18340273112285 0.00139352017659504 NA NA NA hsa-miR-425-5p PTCHD1 0.0936889263324847 0.932870183198261 -0.631336037582281 0.304705378550034 mirMAP -0.88887611555513 1.08820675891532e-09 NA NA NA hsa-miR-425-5p PTPN7 0.0936889263324847 0.932870183198261 -0.224381203653959 0.657203894464633 MirTarget -0.225664838651915 0.0337237016914669 NA NA NA hsa-miR-425-5p PTPRT 0.0936889263324847 0.932870183198261 -0.344345311442128 0.538320850320105 mirMAP -0.535011950365216 2.26299251980459e-05 NA NA NA hsa-miR-425-5p QKI 0.0936889263324847 0.932870183198261 0.0766574767067612 0.908057533664055 miRNAWalker2_validate -0.45315409362993 1.15696811544356e-12 NA NA NA hsa-miR-425-5p RAB8B 0.0936889263324847 0.932870183198261 -0.024612841823898 0.967845597000627 miRNATAP -0.246910080181876 2.38068122553953e-11 NA NA NA hsa-miR-425-5p RABGAP1L 0.0936889263324847 0.932870183198261 0.0505778274244588 0.92426592261184 miRNATAP -0.161798733876208 6.78391148675716e-06 NA NA NA hsa-miR-425-5p RGS13 0.0936889263324847 0.932870183198261 -0.0209329774058546 0.971040255561916 MirTarget -0.369262971907019 0.00614934162151184 NA NA NA hsa-miR-425-5p RNF11 0.0936889263324847 0.932870183198261 -0.0569982451221245 0.944174095501697 MirTarget;miRNATAP -0.12827643057976 4.97188012405704e-06 NA NA NA hsa-miR-425-5p RNF168 0.0936889263324847 0.932870183198261 -0.266746883743366 0.535210340371773 MirTarget -0.1188477538956 0.00349649092874074 NA NA NA hsa-miR-425-5p RYR2 0.0936889263324847 0.932870183198261 0.115475551035294 0.779447862816187 MirTarget -0.621336167203354 2.75459361253947e-07 NA NA NA hsa-miR-425-5p SAMD4A 0.0936889263324847 0.932870183198261 0.0159106367746644 0.977281456587223 miRNATAP -0.390874968871047 9.10535370749278e-11 NA NA NA hsa-miR-425-5p SCN4B 0.0936889263324847 0.932870183198261 -0.177942737102984 0.564849558722256 mirMAP -0.544241197511909 1.00506575294664e-09 NA NA NA hsa-miR-425-5p SERPINE1 0.0936889263324847 0.932870183198261 0.157983352731243 0.84596098281296 MirTarget;miRNATAP -0.539837029629402 3.22785867994715e-09 NA NA NA hsa-miR-425-5p SLC1A2 0.0936889263324847 0.932870183198261 -0.337381644320611 0.434229505277503 mirMAP -0.373777276937359 2.92197439373214e-05 NA NA NA hsa-miR-425-5p SMAD4 0.0936889263324847 0.932870183198261 -0.234351069245961 0.765814252430755 mirMAP -0.130531407894903 0.00133502406681675 NA NA NA hsa-miR-425-5p SNAP91 0.0936889263324847 0.932870183198261 -0.545917991686362 0.41299282531489 miRNATAP -0.783309900924995 5.75075930036651e-10 NA NA NA hsa-miR-425-5p SSBP2 0.0936889263324847 0.932870183198261 0.388366878170918 0.267840806979019 mirMAP -0.475158720682851 3.51731756974522e-08 NA NA NA hsa-miR-425-5p SYNJ1 0.0936889263324847 0.932870183198261 0.0121680344683588 0.979223600787825 miRNATAP -0.101654894245476 0.001329047811672 NA NA NA hsa-miR-425-5p SYT2 0.0936889263324847 0.932870183198261 0.244676972194228 0.433409273869875 mirMAP -0.188626987641222 0.0200018417428074 NA NA NA hsa-miR-425-5p TAOK1 0.0936889263324847 0.932870183198261 -0.326984533068038 0.548112365432775 miRNAWalker2_validate -0.22972866277421 1.37916046631797e-05 NA NA NA hsa-miR-425-5p TBCEL 0.0936889263324847 0.932870183198261 -0.113470119934545 0.806669727540838 MirTarget -0.200441187946229 5.29491671575864e-05 NA NA NA hsa-miR-425-5p TEAD1 0.0936889263324847 0.932870183198261 -0.0998871873210252 0.908003783495983 mirMAP -0.11623892030302 0.0002650469705325 NA NA NA hsa-miR-425-5p THEMIS 0.0936889263324847 0.932870183198261 -0.199311358189063 0.583519265091887 MirTarget -0.355307951785886 0.000942359921143182 NA NA NA hsa-miR-425-5p THRB 0.0936889263324847 0.932870183198261 -0.494241572722375 0.357430599689219 MirTarget;miRNATAP -0.350280713456607 0.00812562638652289 NA NA NA hsa-miR-425-5p TIFAB 0.0936889263324847 0.932870183198261 -0.186150650392732 0.702831403348986 mirMAP -0.285328774987778 0.0128687100500927 NA NA NA hsa-miR-425-5p TNC 0.0936889263324847 0.932870183198261 -0.0382757756047187 0.969132564440715 MirTarget -0.850714410407433 1.10857894452288e-14 NA NA NA hsa-miR-425-5p TNS1 0.0936889263324847 0.932870183198261 -0.0852174376184625 0.928021624667819 mirMAP -0.879605854793122 8.02086455616924e-24 24571667 Here we show that IL-1β induces the upregulation of miR-425 which negatively regulates phosphatase and tensin homolog expression by targeting its 3' UTR; Consequently repression of phosphatase and tensin homolog by miR-425 promotes gastric cancer cell proliferation which is required to protect cells from cisplatin-induced apoptosis; Taken together our data support a critical role for NF-kappaB-dependent upregulation of miR-425 which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1β induction poor survival gastric cancer hsa-miR-425-5p TTC9 0.0936889263324847 0.932870183198261 0.0312026059464641 0.953753321691224 mirMAP -0.236131363778621 0.00797180738647017 NA NA NA hsa-miR-425-5p WDR7 0.0936889263324847 0.932870183198261 -0.119223005168782 0.821717424319121 mirMAP -0.179217685378722 2.93306108463937e-06 NA NA NA hsa-miR-425-5p WTIP 0.0936889263324847 0.932870183198261 0.107495425097089 0.756631278255679 mirMAP -0.428098680947725 5.96901532547516e-11 NA NA NA hsa-miR-425-5p ZFP82 0.0936889263324847 0.932870183198261 0.207611320900984 0.498872007290826 MirTarget -0.395668777932982 1.51832814286583e-05 NA NA NA hsa-miR-425-5p ZMAT3 0.0936889263324847 0.932870183198261 -0.175245711512314 0.578030320008273 MirTarget -0.271424474292441 5.32072386787997e-06 NA NA NA hsa-miR-425-5p ZNF423 0.0936889263324847 0.932870183198261 0.277238415051008 0.522015608910877 MirTarget;miRNATAP -0.29576761811083 0.00148415379721555 NA NA NA hsa-miR-425-5p ZNF677 0.0936889263324847 0.932870183198261 -0.218265859132458 0.588874948884276 mirMAP -0.552950640388341 2.16006165445656e-10 NA NA NA