miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p AKT3 -1.46099200329485 7.85040381494472e-22 0.757395805826156 5.24354425444781e-05 PITA;miRanda -0.204988506808972 7.26517518198736e-05 NA NA NA hsa-miR-15a-5p AKT3 0.783550182002274 2.60699595655907e-11 0.757395805826156 5.24354425444781e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265716982670402 0.000109391971495535 NA NA NA hsa-miR-17-5p AKT3 1.41924888736771 2.75805544953758e-18 0.757395805826156 5.24354425444781e-05 TargetScan;miRNATAP -0.210478431167346 1.46778910374435e-05 NA NA NA hsa-miR-205-3p AKT3 1.2960640797621 5.80786479909147e-11 0.757395805826156 5.24354425444781e-05 mirMAP -0.248708307357298 5.71786142986847e-10 NA NA NA hsa-miR-20a-5p AKT3 1.1531986665452 1.02385132917958e-11 0.757395805826156 5.24354425444781e-05 miRNATAP -0.244010493055021 2.19437052623105e-07 NA NA NA hsa-miR-29b-3p AKT3 -0.110721443686039 0.511264554091106 0.757395805826156 5.24354425444781e-05 miRNATAP -0.255169036216248 1.32894370465011e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-362-3p AKT3 -0.697212068252854 2.61718493418184e-06 0.757395805826156 5.24354425444781e-05 miRanda -0.198442787422331 0.000314248564221821 NA NA NA hsa-miR-362-5p AKT3 0.41089772861323 0.0404254902071382 0.757395805826156 5.24354425444781e-05 PITA;TargetScan;miRNATAP -0.156881795440952 0.000120211641903581 NA NA NA hsa-miR-141-3p CBL 0.730011517758706 0.000120338355004032 0.362857804430257 0.0025244127412177 MirTarget;TargetScan;mirMAP -0.117412740200101 1.74617097122269e-05 NA NA NA hsa-miR-199a-5p CBL -0.364835768178638 0.0435119211101981 0.362857804430257 0.0025244127412177 MirTarget;PITA;miRNATAP -0.118006281256044 4.43311992589427e-05 NA NA NA hsa-miR-199b-5p CBL -1.08432682485992 7.68241801134089e-10 0.362857804430257 0.0025244127412177 MirTarget;PITA -0.129305100380738 8.97176467130899e-06 NA NA NA hsa-miR-19a-3p CBL 1.35800152353624 2.80940447111944e-12 0.362857804430257 0.0025244127412177 mirMAP -0.131875172014027 4.74077504908793e-07 NA NA NA hsa-miR-19b-3p CBL 0.538732279378089 0.000622008277870679 0.362857804430257 0.0025244127412177 mirMAP -0.18941808086524 7.9504378731609e-09 NA NA NA hsa-miR-200a-3p CBL 0.607140814457753 0.00289840524858752 0.362857804430257 0.0025244127412177 MirTarget;mirMAP -0.128573131993653 4.28406939674027e-07 NA NA NA hsa-miR-20a-5p CBL 1.1531986665452 1.02385132917958e-11 0.362857804430257 0.0025244127412177 mirMAP -0.120968905848537 6.26885672568909e-05 NA NA NA hsa-miR-29b-3p CBL -0.110721443686039 0.511264554091106 0.362857804430257 0.0025244127412177 mirMAP -0.164604840776251 9.81212713682985e-08 NA NA NA hsa-miR-30d-3p CBL -0.577371911152798 2.02950840095287e-06 0.362857804430257 0.0025244127412177 MirTarget -0.212228516821087 6.76296322148646e-07 NA NA NA hsa-miR-320a CBL 0.801356001806321 4.91397101474502e-09 0.362857804430257 0.0025244127412177 miRNATAP -0.109043494664013 0.00395602089885274 NA NA NA hsa-miR-338-3p CBL -0.948755228846395 8.99167125682392e-08 0.362857804430257 0.0025244127412177 miRNATAP -0.173841851121068 1.61739320294669e-09 NA NA NA hsa-miR-342-3p CBL 0.99756868977753 9.28499866272332e-10 0.362857804430257 0.0025244127412177 mirMAP -0.147575655855985 2.77980571038434e-06 NA NA NA hsa-miR-374a-3p CBL -0.299190081500425 0.00682975596757891 0.362857804430257 0.0025244127412177 mirMAP -0.158707090717516 0.000851593457499411 NA NA NA hsa-miR-374b-5p CBL -0.288413933608091 0.0041474558664058 0.362857804430257 0.0025244127412177 mirMAP -0.214454208241846 4.06882541827578e-05 NA NA NA hsa-miR-429 CBL 0.559451508722375 0.00563641638673083 0.362857804430257 0.0025244127412177 MirTarget;PITA;mirMAP;miRNATAP -0.104343786424931 5.17709607845614e-05 NA NA NA hsa-miR-497-5p CBL -0.966244470847844 5.26505649147857e-12 0.362857804430257 0.0025244127412177 mirMAP -0.115039610238377 0.00173882528483315 NA NA NA hsa-miR-501-3p CBL 0.820141346319976 1.74562930463389e-08 0.362857804430257 0.0025244127412177 TargetScan -0.104229558468218 0.00347236177754676 NA NA NA hsa-miR-576-5p CBL 0.940432050128373 6.90227595663302e-12 0.362857804430257 0.0025244127412177 mirMAP -0.104398034344641 0.00548191672849191 NA NA NA hsa-miR-590-5p CBL 0.763025362395968 3.65305892505623e-09 0.362857804430257 0.0025244127412177 mirMAP -0.105059544194042 0.00883642510151819 NA NA NA hsa-miR-664a-3p CBL -0.256108763664991 0.0513188660751664 0.362857804430257 0.0025244127412177 mirMAP -0.227648383643306 8.79410729753303e-09 NA NA NA hsa-miR-126-5p CBLB -0.953529188793816 7.91719143295591e-16 1.00001735532555 2.84951349498502e-16 mirMAP -0.12687218009912 0.00505426477444313 NA NA NA hsa-miR-139-5p CBLB -1.46099200329485 7.85040381494472e-22 1.00001735532555 2.84951349498502e-16 miRanda -0.139503001335686 5.26309096014546e-05 NA NA NA hsa-miR-30a-5p CBLB -1.79779915425811 1.93360169837799e-26 1.00001735532555 2.84951349498502e-16 MirTarget -0.154069724827595 4.8078745582151e-07 NA NA NA hsa-miR-30b-5p CBLB -0.400238605368173 0.00346540992719245 1.00001735532555 2.84951349498502e-16 MirTarget;mirMAP -0.157945159061296 7.68627168416786e-05 NA NA NA hsa-miR-30c-5p CBLB 0.021222006155897 0.886366656528128 1.00001735532555 2.84951349498502e-16 MirTarget;mirMAP -0.154371868668821 2.88413840617349e-05 NA NA NA hsa-miR-30e-5p CBLB -1.02114836019762 6.81961221797866e-17 1.00001735532555 2.84951349498502e-16 MirTarget -0.198608249264382 4.75217590333087e-06 NA NA NA hsa-miR-576-5p CBLB 0.940432050128373 6.90227595663302e-12 1.00001735532555 2.84951349498502e-16 mirMAP -0.107927398052424 0.0060558595396952 NA NA NA hsa-let-7g-5p CCND1 -0.250780249469264 0.00939610188330072 -0.0109881197784345 0.959465409721582 miRNATAP -0.424829740163156 1.3974509451707e-05 NA NA NA hsa-miR-106a-5p CCND1 0.67978010057847 0.00221925869726092 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.290355514799433 2.22440819238953e-12 NA NA NA hsa-miR-1266-5p CCND1 -0.595481713934774 0.0201336437562675 -0.0109881197784345 0.959465409721582 MirTarget -0.139245086566564 0.000186104290921039 NA NA NA hsa-miR-142-3p CCND1 1.12754191614028 1.68798138028946e-08 -0.0109881197784345 0.959465409721582 miRanda -0.212388247517233 4.15485864028608e-06 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 0.288897753038094 0.0900009317815725 -0.0109881197784345 0.959465409721582 PITA -0.191106128320911 0.000532572974747186 NA NA NA hsa-miR-150-5p CCND1 -0.243749814009231 0.331546276920338 -0.0109881197784345 0.959465409721582 mirMAP -0.180131286994855 1.27780213542857e-06 NA NA NA hsa-miR-155-5p CCND1 0.533437622040649 0.00248671179205372 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.205881873012998 0.000104382699617692 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15a-5p CCND1 0.783550182002274 2.60699595655907e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320464086146859 4.59241835770022e-05 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 0.85315666454713 3.79816274836297e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196519284459032 0.00913339894150689 NA NA NA hsa-miR-16-1-3p CCND1 0.955017760172879 5.95379292601146e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.299307340787817 2.12501301813106e-06 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.521122945828175 1.40561786410572e-06 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36160545188711 2.92815156758109e-05 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-19a-3p CCND1 1.35800152353624 2.80940447111944e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12556465980021 0.0080645437414565 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.757034032029085 2.99828133413343e-07 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.202417906859997 0.00132907107963613 NA NA NA hsa-miR-19b-3p CCND1 0.538732279378089 0.000622008277870679 -0.0109881197784345 0.959465409721582 miRNATAP -0.231848363677157 9.5371115518645e-05 NA NA NA hsa-miR-20a-5p CCND1 1.1531986665452 1.02385132917958e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150528956777027 0.00569825749150082 NA NA NA hsa-miR-20b-5p CCND1 0.345967670847176 0.232014828043601 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.250103392191291 2.8858693936891e-15 NA NA NA hsa-miR-29b-3p CCND1 -0.110721443686039 0.511264554091106 -0.0109881197784345 0.959465409721582 mirMAP -0.182509877041615 0.00109069300418897 NA NA NA hsa-miR-29c-3p CCND1 -2.08166260448948 8.3238369390898e-24 -0.0109881197784345 0.959465409721582 mirMAP -0.163903476961256 0.000152217345834049 NA NA NA hsa-miR-33a-3p CCND1 0.20371038027126 0.212335697664505 -0.0109881197784345 0.959465409721582 MirTarget -0.204409670414224 0.000471939794699908 NA NA NA hsa-miR-34a-5p CCND1 -0.117372471043915 0.364001947180738 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309736660444851 2.09961171943065e-05 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-425-5p CCND1 0.931027421598738 6.46235724408844e-08 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.149225802492201 0.00573052989307961 NA NA NA hsa-miR-497-5p CCND1 -0.966244470847844 5.26505649147857e-12 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.266892367444044 4.86480308910068e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p CCND1 0.221436901462551 0.0965904764063157 -0.0109881197784345 0.959465409721582 mirMAP -0.238086291527056 0.000767975801470639 NA NA NA hsa-miR-7-1-3p CCND1 1.13646121619622 1.49823237535933e-14 -0.0109881197784345 0.959465409721582 mirMAP -0.221180507811752 0.000359772635429063 NA NA NA hsa-miR-9-5p CCND1 1.65694862043766 2.08325802567323e-05 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.135043708232949 1.13694784335034e-08 NA NA NA hsa-miR-92a-3p CCND1 0.994679542307232 1.32587679156217e-16 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.235491439560111 0.00199944237198536 NA NA NA hsa-miR-942-5p CCND1 0.678652135586536 2.58063518495056e-07 -0.0109881197784345 0.959465409721582 MirTarget -0.230928848103094 0.0011113987419772 NA NA NA hsa-miR-224-3p CCND2 0.502645536188015 0.0081142387260641 0.148711904010299 0.532420631377314 mirMAP -0.312870902501466 8.12446049333883e-09 NA NA NA hsa-miR-27b-3p CCND3 -0.732682718863563 2.26896143573324e-09 -0.048043868607146 0.631560985924681 miRNAWalker2_validate -0.132150579088403 0.000160876577060277 NA NA NA hsa-miR-24-3p CISH 0.13115428390042 0.203891651275156 -0.856762436133697 3.24871712838021e-11 MirTarget -0.145821274654613 0.00932923004295684 NA NA NA hsa-miR-324-5p CISH 1.66709479707179 1.45961450445769e-23 -0.856762436133697 3.24871712838021e-11 miRanda -0.196756721213055 1.3449531956879e-09 NA NA NA hsa-miR-361-5p CISH 0.0803683277369505 0.314043140368058 -0.856762436133697 3.24871712838021e-11 miRanda -0.273041061307956 0.000180388845262519 NA NA NA hsa-miR-30a-5p CLCF1 -1.79779915425811 1.93360169837799e-26 0.647967436771911 0.00137053013714127 miRNATAP -0.148783206051653 0.00280500455156757 NA NA NA hsa-miR-30d-5p CLCF1 -0.38399848121878 0.000171129616944749 0.647967436771911 0.00137053013714127 miRNATAP -0.374949153830469 1.46324751622382e-05 NA NA NA hsa-miR-146b-5p CNTF 0.917975986853978 3.33749259316025e-09 -0.568937656312522 0.00214515816844321 MirTarget;miRanda -0.185783288217711 0.000299457966383735 NA NA NA hsa-miR-146b-5p CNTFR 0.917975986853978 3.33749259316025e-09 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.296653631495252 0.00716181429092805 NA NA NA hsa-miR-1976 CNTFR 0.638808083289405 2.94840228896364e-07 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.576164679569211 2.8644203183383e-05 NA NA NA hsa-miR-19a-3p CNTFR 1.35800152353624 2.80940447111944e-12 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.364550245366014 2.74439153820369e-05 NA NA NA hsa-miR-200c-3p CNTFR 0.630251054099546 0.000131975031451555 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.599227591306362 7.04823253902852e-09 NA NA NA hsa-miR-21-5p CNTFR 1.62465922021121 3.44191300985109e-58 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.973520418147062 1.29690784051072e-10 NA NA NA hsa-miR-24-3p CNTFR 0.13115428390042 0.203891651275156 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.453968210957325 0.00746582563425062 NA NA NA hsa-miR-429 CNTFR 0.559451508722375 0.00563641638673083 -3.32072996488131 5.91297364100708e-18 PITA;miRanda;miRNATAP -0.251264435451119 0.00332727643114729 NA NA NA hsa-miR-589-5p CNTFR 0.807877250867909 4.12262850391353e-14 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.585648822596089 0.000228619218999046 NA NA NA hsa-miR-708-5p CNTFR 1.54207894190626 2.2887257992285e-19 -3.32072996488131 5.91297364100708e-18 miRNATAP -0.321720579288753 0.000970258705673356 NA NA NA hsa-let-7a-3p CREBBP 0.0966652362351867 0.423761916840503 0.0211259388253167 0.833615761874968 miRNATAP -0.141728011100707 9.23516643213276e-05 NA NA NA hsa-miR-186-5p CREBBP 0.353452958261612 0.000145058448579496 0.0211259388253167 0.833615761874968 mirMAP;miRNATAP -0.266935526900469 1.07011235526747e-08 NA NA NA hsa-miR-26b-5p CREBBP -0.254478038884324 0.0285227763044636 0.0211259388253167 0.833615761874968 miRNATAP -0.214346125460379 9.40206492009562e-09 NA NA NA hsa-miR-30d-3p CREBBP -0.577371911152798 2.02950840095287e-06 0.0211259388253167 0.833615761874968 MirTarget;miRNATAP -0.125103816738256 0.000472569063529424 NA NA NA hsa-miR-590-3p CREBBP 0.221436901462551 0.0965904764063157 0.0211259388253167 0.833615761874968 PITA;miRanda;mirMAP;miRNATAP -0.10121443711021 0.00207914002999387 NA NA NA hsa-miR-34c-5p CSF2RA 0.565896455062849 0.0224052732281715 -0.239940046213909 0.170158325722526 miRanda -0.108653136953072 0.000388842450464623 NA NA NA hsa-miR-361-5p CSF2RA 0.0803683277369505 0.314043140368058 -0.239940046213909 0.170158325722526 miRanda -0.377830473540258 9.53149783542152e-05 NA NA NA hsa-miR-429 CSF2RA 0.559451508722375 0.00563641638673083 -0.239940046213909 0.170158325722526 miRanda -0.175483298017873 2.61527846231058e-06 NA NA NA hsa-miR-19a-3p CSF2RB 1.35800152353624 2.80940447111944e-12 -0.372030110911936 0.0859683504965578 MirTarget -0.320861956956304 6.14762600843802e-12 NA NA NA hsa-miR-19b-3p CSF2RB 0.538732279378089 0.000622008277870679 -0.372030110911936 0.0859683504965578 MirTarget -0.359322825161025 1.13744786185385e-09 NA NA NA hsa-miR-452-3p CSF2RB 1.09618110917892 2.21867884261816e-07 -0.372030110911936 0.0859683504965578 mirMAP -0.199677061117346 5.22034394239656e-06 NA NA NA hsa-miR-455-5p CSF2RB 1.408595672323 5.52039116456697e-22 -0.372030110911936 0.0859683504965578 miRanda -0.352399241717837 9.26746136503431e-09 NA NA NA hsa-miR-485-3p CSF2RB 0.359155046663542 0.0929405338270575 -0.372030110911936 0.0859683504965578 MirTarget -0.11667537351305 0.00860054183506795 NA NA NA hsa-miR-493-3p CSF2RB -0.588568690467072 0.00436360724637211 -0.372030110911936 0.0859683504965578 MirTarget -0.119122854389741 0.0091846637598177 NA NA NA hsa-miR-576-5p CSF2RB 0.940432050128373 6.90227595663302e-12 -0.372030110911936 0.0859683504965578 miRNATAP -0.190683686661979 0.00484263176970127 NA NA NA hsa-miR-361-5p CSF3R 0.0803683277369505 0.314043140368058 0.718899439132889 0.00193557981840307 miRanda -0.503779960182056 9.28501921314817e-05 NA NA NA hsa-miR-429 CSF3R 0.559451508722375 0.00563641638673083 0.718899439132889 0.00193557981840307 miRanda -0.195207618122359 9.08134219311384e-05 NA NA NA hsa-miR-185-5p CTF1 0.675225177054909 1.84953949190805e-13 -0.588983135529865 0.00649761541988447 MirTarget -0.32679461642829 0.00129764662643862 NA NA NA hsa-miR-342-3p CTF1 0.99756868977753 9.28499866272332e-10 -0.588983135529865 0.00649761541988447 miRanda -0.17167149338398 0.00264737882433745 NA NA NA hsa-miR-140-5p EP300 -0.412389003031485 0.000136051708543369 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.141884309868302 0.00916642161638672 NA NA NA hsa-miR-181b-5p EP300 0.974255518824355 2.64876280203475e-16 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.250341020065621 1.51463026672172e-07 NA NA NA hsa-miR-182-5p EP300 1.15060905311096 6.25565852529946e-10 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate;miRNATAP -0.109993574014164 0.000382060836125653 NA NA NA hsa-miR-186-5p EP300 0.353452958261612 0.000145058448579496 -0.0380111788778681 0.77827759766468 miRNATAP -0.386320760182696 6.6698828838652e-10 NA NA NA hsa-miR-193b-3p EP300 1.72788400801602 3.0722151264559e-21 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.144257938177827 2.54219199927362e-06 NA NA NA hsa-miR-20a-5p EP300 1.1531986665452 1.02385132917958e-11 -0.0380111788778681 0.77827759766468 miRNATAP -0.261739041685133 2.59407474239911e-15 NA NA NA hsa-miR-2355-3p EP300 1.58434563546762 4.06578912176206e-18 -0.0380111788778681 0.77827759766468 MirTarget;miRNATAP -0.131467353710323 2.13937266933203e-05 NA NA NA hsa-miR-25-3p EP300 0.76549796417801 3.32282098247097e-11 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.173479800768433 0.000532079071469301 NA NA NA hsa-miR-26b-5p EP300 -0.254478038884324 0.0285227763044636 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate;miRNATAP -0.321924572744021 1.18737211357222e-10 NA NA NA hsa-miR-29b-1-5p EP300 1.39669186711325 4.36960953138935e-11 -0.0380111788778681 0.77827759766468 MirTarget -0.175659831997499 5.2666018029895e-11 NA NA NA hsa-miR-30c-5p EP300 0.021222006155897 0.886366656528128 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.354080729396632 2.09783714269189e-20 NA NA NA hsa-miR-30d-3p EP300 -0.577371911152798 2.02950840095287e-06 -0.0380111788778681 0.77827759766468 MirTarget;miRNATAP -0.181263177214702 0.000161995559394236 NA NA NA hsa-miR-339-5p EP300 1.07771430326938 2.45772601859307e-09 -0.0380111788778681 0.77827759766468 miRanda -0.252101380951511 5.72291428931759e-16 NA NA NA hsa-miR-342-3p EP300 0.99756868977753 9.28499866272332e-10 -0.0380111788778681 0.77827759766468 MirTarget;PITA;miRanda;miRNATAP -0.275927662915398 1.41235573597807e-15 NA NA NA hsa-miR-361-3p EP300 0.272298288982435 0.0147874880476998 -0.0380111788778681 0.77827759766468 PITA -0.220028179879572 2.87377466725932e-05 NA NA NA hsa-miR-374b-5p EP300 -0.288413933608091 0.0041474558664058 -0.0380111788778681 0.77827759766468 mirMAP;miRNATAP -0.289679382753077 6.67702137205187e-07 NA NA NA hsa-miR-582-3p EP300 -0.248056267546012 0.143798829508405 -0.0380111788778681 0.77827759766468 MirTarget;PITA -0.110822669216861 0.00136211075647265 NA NA NA hsa-miR-590-3p EP300 0.221436901462551 0.0965904764063157 -0.0380111788778681 0.77827759766468 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.124953760048753 0.00471850055107272 NA NA NA hsa-miR-92a-3p EP300 0.994679542307232 1.32587679156217e-16 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.192864139618897 4.68840854466291e-05 NA NA NA hsa-miR-96-5p EP300 1.42326703011157 4.39736150032373e-14 -0.0380111788778681 0.77827759766468 TargetScan;miRNATAP -0.119689767979309 7.57146931270777e-05 NA NA NA hsa-miR-326 EPO -0.425943992128769 0.0415010315530797 0.948511135768718 0.00514835311333976 miRanda -0.378848774524137 7.47414119649195e-08 NA NA NA hsa-miR-142-3p GHR 1.12754191614028 1.68798138028946e-08 -1.22528587755802 3.47302730555662e-06 MirTarget;PITA;miRanda;miRNATAP -0.297046937673111 1.67230931014283e-07 NA NA NA hsa-miR-15a-5p GHR 0.783550182002274 2.60699595655907e-11 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.634531635641298 3.49495059386986e-11 NA NA NA hsa-miR-15b-5p GHR 0.85315666454713 3.79816274836297e-12 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.384862680839798 3.21223863081852e-05 NA NA NA hsa-miR-16-2-3p GHR 1.1567130855258 1.01867256952189e-14 -1.22528587755802 3.47302730555662e-06 mirMAP -0.487914008383871 5.90046691387845e-11 NA NA NA hsa-miR-16-5p GHR 0.521122945828175 1.40561786410572e-06 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.713465056923056 1.27093052279277e-11 NA NA NA hsa-miR-29a-5p GHR 0.323252792625584 0.0370417231222825 -1.22528587755802 3.47302730555662e-06 mirMAP;miRNATAP -0.334024001831373 7.4993228650486e-06 NA NA NA hsa-miR-3607-3p GHR 1.01377165357363 9.13355519701165e-05 -1.22528587755802 3.47302730555662e-06 mirMAP -0.190894420478056 1.64555470716258e-05 NA NA NA hsa-miR-424-5p GHR 1.48125289532143 9.10372985713165e-19 -1.22528587755802 3.47302730555662e-06 MirTarget;miRNATAP -0.279242524167786 2.83098480468168e-05 NA NA NA hsa-miR-429 GHR 0.559451508722375 0.00563641638673083 -1.22528587755802 3.47302730555662e-06 miRanda;miRNATAP -0.218676579937026 0.000129437279275675 NA NA NA hsa-miR-455-5p GHR 1.408595672323 5.52039116456697e-22 -1.22528587755802 3.47302730555662e-06 miRanda -0.263393172143474 0.000547678735223907 NA NA NA hsa-miR-590-3p GHR 0.221436901462551 0.0965904764063157 -1.22528587755802 3.47302730555662e-06 mirMAP -0.442773746054236 3.30359260287333e-07 NA NA NA hsa-miR-7-1-3p GHR 1.13646121619622 1.49823237535933e-14 -1.22528587755802 3.47302730555662e-06 MirTarget;mirMAP -0.40827457941604 7.52969488687425e-08 NA NA NA hsa-miR-141-3p IFNAR2 0.730011517758706 0.000120338355004032 0.421649896532006 6.88352600382185e-06 mirMAP -0.104709037647682 9.5153496516924e-07 NA NA NA hsa-miR-330-3p IFNE -0.0524949332825773 0.719856123539461 1.72319145709081 4.70407384390381e-06 MirTarget -0.4890011093044 1.53308991418832e-05 NA NA NA hsa-miR-369-3p IFNG -1.2344419076994 2.66882944171146e-10 1.84249795385831 3.83567565371082e-07 PITA;miRNATAP -0.29380970591346 0.000261076667049839 NA NA NA hsa-miR-409-3p IFNG -0.342347118512604 0.0538776384301546 1.84249795385831 3.83567565371082e-07 miRNAWalker2_validate -0.531383796130062 2.29124302429043e-09 NA NA NA hsa-miR-429 IFNG 0.559451508722375 0.00563641638673083 1.84249795385831 3.83567565371082e-07 miRanda -0.224875854636875 0.00439420305661559 NA NA NA hsa-miR-129-5p IFNGR1 -0.246329588499478 0.436451191224681 0.238548441519171 0.0243366992543931 miRanda -0.100392508191943 4.5863903215571e-12 NA NA NA hsa-miR-98-5p IFNGR1 0.0176698653376732 0.858271091070735 0.238548441519171 0.0243366992543931 miRNAWalker2_validate -0.22651482457912 1.29726119426785e-06 NA NA NA hsa-miR-375 IFNK -4.24070205340868 7.48368361454041e-28 1.3589657334569 0.000463189829942388 miRanda -0.12006107252715 0.0037467681117715 NA NA NA hsa-miR-27b-3p IL10 -0.732682718863563 2.26896143573324e-09 0.688348207979631 0.000838909944797236 miRNATAP -0.317878814787489 1.13309054373374e-05 NA NA NA hsa-miR-361-5p IL10 0.0803683277369505 0.314043140368058 0.688348207979631 0.000838909944797236 MirTarget;PITA;miRanda;miRNATAP -0.477606364415722 3.03374665334027e-05 NA NA NA hsa-miR-590-5p IL10 0.763025362395968 3.65305892505623e-09 0.688348207979631 0.000838909944797236 miRanda -0.19479596614484 0.0047333605778142 NA NA NA hsa-miR-769-5p IL10 0.0865819375213306 0.445395188017017 0.688348207979631 0.000838909944797236 miRNATAP -0.318474185377013 6.58207716928101e-05 NA NA NA hsa-miR-455-5p IL10RA 1.408595672323 5.52039116456697e-22 0.213264138347756 0.301213895235825 miRanda -0.262628267417479 7.72945249218175e-06 NA NA NA hsa-miR-140-5p IL11 -0.412389003031485 0.000136051708543369 4.17591929328951 2.12082647538738e-42 miRanda -0.425896591627434 0.00154419717270683 NA NA NA hsa-miR-23b-3p IL11 -0.497563803223134 3.31483353357535e-05 4.17591929328951 2.12082647538738e-42 miRNATAP -0.816908894838932 6.04077898697811e-12 NA NA NA hsa-miR-125a-5p IL12RB2 0.215366061934933 0.119550904549401 1.31444496055573 7.43774977052584e-05 miRanda -0.363025716342097 0.000570778847070669 NA NA NA hsa-miR-129-5p IL12RB2 -0.246329588499478 0.436451191224681 1.31444496055573 7.43774977052584e-05 miRanda -0.196218454387269 2.39030402090726e-05 NA NA NA hsa-miR-199a-5p IL12RB2 -0.364835768178638 0.0435119211101981 1.31444496055573 7.43774977052584e-05 miRanda -0.416706670617934 1.76590061297805e-07 NA NA NA hsa-miR-199b-5p IL12RB2 -1.08432682485992 7.68241801134089e-10 1.31444496055573 7.43774977052584e-05 miRanda -0.451191311505635 1.96867011991019e-08 NA NA NA hsa-miR-28-5p IL12RB2 -0.026996999089909 0.733047113251652 1.31444496055573 7.43774977052584e-05 miRanda -0.829025173435517 8.59749449540277e-06 NA NA NA hsa-miR-128-3p IL13RA1 -0.170677254601174 0.20412808476528 -0.470986909586638 1.29815712458539e-05 MirTarget -0.100432164940551 0.00453366942430563 NA NA NA hsa-miR-16-2-3p IL13RA1 1.1567130855258 1.01867256952189e-14 -0.470986909586638 1.29815712458539e-05 MirTarget -0.211592479279457 2.92064980411649e-12 NA NA NA hsa-miR-188-5p IL13RA1 0.559328953885106 0.000430338888594543 -0.470986909586638 1.29815712458539e-05 MirTarget;miRNATAP -0.143418527833527 1.29198112367611e-06 NA NA NA hsa-miR-28-5p IL13RA1 -0.026996999089909 0.733047113251652 -0.470986909586638 1.29815712458539e-05 miRanda -0.31933200642753 1.23273445021622e-07 NA NA NA hsa-miR-324-5p IL13RA1 1.66709479707179 1.45961450445769e-23 -0.470986909586638 1.29815712458539e-05 miRanda -0.193378228937614 3.64998043406975e-13 NA NA NA hsa-miR-331-5p IL13RA1 0.851618030062133 1.42670149420057e-14 -0.470986909586638 1.29815712458539e-05 miRNATAP -0.170347094290122 4.53359565292823e-05 NA NA NA hsa-miR-590-3p IL13RA1 0.221436901462551 0.0965904764063157 -0.470986909586638 1.29815712458539e-05 miRanda;mirMAP -0.135690447470283 0.000135691727761717 NA NA NA hsa-miR-7-1-3p IL13RA1 1.13646121619622 1.49823237535933e-14 -0.470986909586638 1.29815712458539e-05 MirTarget;mirMAP -0.200367217706144 7.29962598723519e-11 NA NA NA hsa-miR-129-5p IL15 -0.246329588499478 0.436451191224681 0.494783341035657 0.0111096202551855 miRanda -0.148947487125466 3.37892748873978e-08 NA NA NA hsa-miR-130b-3p IL15 1.44628430084411 9.13980959861273e-24 0.494783341035657 0.0111096202551855 MirTarget -0.180052152484255 0.00144876901753826 NA NA NA hsa-miR-152-3p IL15 -0.382486223604156 0.00710736505198702 0.494783341035657 0.0111096202551855 MirTarget -0.29636177778451 6.14815500749635e-07 NA NA NA hsa-miR-421 IL15 0.945488088619653 2.35762398527362e-09 0.494783341035657 0.0111096202551855 miRanda -0.178667688755379 0.000758041874918459 NA NA NA hsa-miR-429 IL15 0.559451508722375 0.00563641638673083 0.494783341035657 0.0111096202551855 miRanda -0.144748886371384 0.000551368345718773 NA NA NA hsa-miR-493-5p IL15 -0.471586962917071 0.0221327433064002 0.494783341035657 0.0111096202551855 MirTarget -0.144066091810056 0.000472389704884858 NA NA NA hsa-miR-944 IL15 1.47323925060177 2.61626403984929e-13 0.494783341035657 0.0111096202551855 miRNATAP -0.211329085597943 2.2937662851254e-07 NA NA NA hsa-miR-199b-5p IL15RA -1.08432682485992 7.68241801134089e-10 0.793621850333225 1.12128452357882e-08 miRanda -0.111141050078316 0.00116530562912703 NA NA NA hsa-miR-107 IL20 -0.0447040564279497 0.671618791096755 -0.13705893867777 0.759390548732448 miRanda -0.928149950922112 5.28115332881798e-07 NA NA NA hsa-miR-186-5p IL20RA 0.353452958261612 0.000145058448579496 -1.18420855207441 6.96749942569136e-07 mirMAP -0.404585547512966 0.000359967553041887 NA NA NA hsa-miR-28-5p IL20RB -0.026996999089909 0.733047113251652 0.778184967700843 0.00782230457863069 miRanda -1.17762661956539 2.60825750740195e-13 NA NA NA hsa-miR-374b-3p IL20RB 0.425603499218802 0.00146686864653282 0.778184967700843 0.00782230457863069 MirTarget -0.270551293318176 0.00481422075467226 NA NA NA hsa-miR-24-2-5p IL21R 1.27293931700635 4.48240091510596e-15 1.24638512381006 6.08652685018373e-07 MirTarget -0.236849350078669 0.000324015200300328 NA NA NA hsa-miR-24-3p IL21R 0.13115428390042 0.203891651275156 1.24638512381006 6.08652685018373e-07 MirTarget -0.392964601521659 0.000251424242207695 NA NA NA hsa-miR-125a-5p IL22RA1 0.215366061934933 0.119550904549401 -0.0317236350837184 0.881809489405855 miRanda -0.179559920758169 0.00771265443143832 NA NA NA hsa-miR-129-5p IL22RA2 -0.246329588499478 0.436451191224681 1.70767873626758 8.69551655180075e-08 miRanda -0.140559507090627 0.00183514341162931 NA NA NA hsa-miR-199b-5p IL2RA -1.08432682485992 7.68241801134089e-10 1.64995620609536 3.01415367709319e-13 miRanda -0.224399122351766 6.46576537902014e-05 NA NA NA hsa-miR-224-3p IL2RA 0.502645536188015 0.0081142387260641 1.64995620609536 3.01415367709319e-13 MirTarget -0.19680158896281 0.000224088346292478 NA NA NA hsa-miR-3065-3p IL2RA -0.543069092777161 0.0213164885178151 1.64995620609536 3.01415367709319e-13 MirTarget -0.306455409147719 2.26068282981825e-13 NA NA NA hsa-miR-375 IL2RA -4.24070205340868 7.48368361454041e-28 1.64995620609536 3.01415367709319e-13 miRanda -0.178954859476608 1.02371510725154e-13 NA NA NA hsa-miR-125a-5p IL2RB 0.215366061934933 0.119550904549401 0.46694737201397 0.0313292505714046 miRanda -0.22311321687513 0.00113345274921199 NA NA NA hsa-miR-145-5p IL2RB -0.46917511594055 0.000685297625493134 0.46694737201397 0.0313292505714046 mirMAP -0.263756357761351 0.000109679838824784 NA NA NA hsa-miR-299-5p IL2RB -1.92445654064493 1.52402531359074e-16 0.46694737201397 0.0313292505714046 mirMAP -0.128864808127416 0.00107831713995579 NA NA NA hsa-miR-199a-5p IL4R -0.364835768178638 0.0435119211101981 0.235292415840093 0.0918561844265687 miRNATAP -0.10472059568867 0.00183087225916112 NA NA NA hsa-miR-217 IL4R -1.35391381055929 2.42394951427902e-09 0.235292415840093 0.0918561844265687 miRanda -0.135326204754466 2.19312199549138e-07 NA NA NA hsa-miR-491-5p IL4R -0.541680329196715 0.00135829217561865 0.235292415840093 0.0918561844265687 miRanda -0.173123087941089 3.47228894406629e-06 NA NA NA hsa-miR-361-5p IL6 0.0803683277369505 0.314043140368058 -1.04839267298997 0.0016427378053848 miRanda -0.543676267944881 0.00342457947633898 NA NA NA hsa-miR-429 IL6 0.559451508722375 0.00563641638673083 -1.04839267298997 0.0016427378053848 miRanda -0.394149454338654 2.99901296473304e-08 NA NA NA hsa-miR-103a-2-5p IL6R 1.37988337975616 6.74852943995612e-08 -0.0486500175487801 0.809389037083792 mirMAP -0.210431778055292 8.07930168735818e-09 NA NA NA hsa-miR-106a-5p IL6R 0.67978010057847 0.00221925869726092 -0.0486500175487801 0.809389037083792 mirMAP -0.207404631611843 1.0249352303409e-07 NA NA NA hsa-miR-125a-5p IL6R 0.215366061934933 0.119550904549401 -0.0486500175487801 0.809389037083792 MirTarget;miRanda -0.402717109339623 1.30969889036748e-10 NA NA NA hsa-miR-125b-5p IL6R -0.993460109818276 5.07736727659894e-12 -0.0486500175487801 0.809389037083792 miRTarBase;MirTarget -0.224605478876623 0.000168441856363728 22942733 The ectopic expression of miR-125b reduced the cellular proliferation and cell cycle progression of HCC cells by targeting Mcl-1 and IL6R progression liver cancer hsa-miR-130a-3p IL6R 0.67051191119964 4.89747518735144e-06 -0.0486500175487801 0.809389037083792 mirMAP -0.291535575619973 7.73164538793701e-07 NA NA NA hsa-miR-135b-5p IL6R 1.5570143078477 4.60753610971455e-13 -0.0486500175487801 0.809389037083792 mirMAP -0.106216670329152 0.00768110389353497 NA NA NA hsa-miR-141-3p IL6R 0.730011517758706 0.000120338355004032 -0.0486500175487801 0.809389037083792 MirTarget -0.207689091678661 5.52124490800715e-06 NA NA NA hsa-miR-146b-5p IL6R 0.917975986853978 3.33749259316025e-09 -0.0486500175487801 0.809389037083792 miRanda -0.157850889636848 0.00467164876145446 NA NA NA hsa-miR-155-5p IL6R 0.533437622040649 0.00248671179205372 -0.0486500175487801 0.809389037083792 MirTarget -0.15237980071983 0.00213783871461113 NA NA NA hsa-miR-17-5p IL6R 1.41924888736771 2.75805544953758e-18 -0.0486500175487801 0.809389037083792 mirMAP -0.226751100466577 1.25028986887258e-05 NA NA NA hsa-miR-182-5p IL6R 1.15060905311096 6.25565852529946e-10 -0.0486500175487801 0.809389037083792 mirMAP -0.143065481809668 0.00203379307788197 NA NA NA hsa-miR-186-5p IL6R 0.353452958261612 0.000145058448579496 -0.0486500175487801 0.809389037083792 mirMAP -0.406198626543001 1.70086573072698e-05 NA NA NA hsa-miR-192-5p IL6R 0.380924502586635 0.00986961967409205 -0.0486500175487801 0.809389037083792 mirMAP -0.206425553709301 0.000508804045128702 NA NA NA hsa-miR-197-3p IL6R 0.878693269130833 3.84847526014135e-15 -0.0486500175487801 0.809389037083792 MirTarget -0.205600134792494 0.00750031892225504 NA NA NA hsa-miR-200a-3p IL6R 0.607140814457753 0.00289840524858752 -0.0486500175487801 0.809389037083792 MirTarget -0.211507618263558 6.79944513522847e-07 NA NA NA hsa-miR-20a-5p IL6R 1.1531986665452 1.02385132917958e-11 -0.0486500175487801 0.809389037083792 mirMAP -0.292895025834035 5.22283508164814e-09 NA NA NA hsa-miR-20b-5p IL6R 0.345967670847176 0.232014828043601 -0.0486500175487801 0.809389037083792 mirMAP -0.231547507176398 4.77534103525254e-15 NA NA NA hsa-miR-29a-5p IL6R 0.323252792625584 0.0370417231222825 -0.0486500175487801 0.809389037083792 mirMAP -0.236572190147455 2.76738607194933e-05 NA NA NA hsa-miR-301a-3p IL6R 2.14132004241926 4.46255413526808e-25 -0.0486500175487801 0.809389037083792 mirMAP -0.179160081092364 8.05822285018416e-06 NA NA NA hsa-miR-30a-5p IL6R -1.79779915425811 1.93360169837799e-26 -0.0486500175487801 0.809389037083792 mirMAP -0.240383543244608 9.339773290795e-07 NA NA NA hsa-miR-30b-5p IL6R -0.400238605368173 0.00346540992719245 -0.0486500175487801 0.809389037083792 mirMAP -0.389384992570436 7.44134431805409e-10 NA NA NA hsa-miR-30c-5p IL6R 0.021222006155897 0.886366656528128 -0.0486500175487801 0.809389037083792 mirMAP -0.413354869962516 1.1682658103537e-12 NA NA NA hsa-miR-320a IL6R 0.801356001806321 4.91397101474502e-09 -0.0486500175487801 0.809389037083792 miRanda;miRNATAP -0.362518536672091 6.91550938771451e-09 NA NA NA hsa-miR-34a-5p IL6R -0.117372471043915 0.364001947180738 -0.0486500175487801 0.809389037083792 MirTarget -0.630509408577177 6.97948912426972e-22 NA NA NA hsa-miR-361-3p IL6R 0.272298288982435 0.0147874880476998 -0.0486500175487801 0.809389037083792 MirTarget -0.389865552116126 6.55313745503612e-07 NA NA NA hsa-miR-454-3p IL6R 1.54137391927201 4.15861570449376e-20 -0.0486500175487801 0.809389037083792 mirMAP -0.336428933853486 1.05104072133221e-11 NA NA NA hsa-miR-501-5p IL6R 1.02806906860218 1.63456814370548e-09 -0.0486500175487801 0.809389037083792 miRNATAP -0.213835594012355 2.94955017701203e-05 NA NA NA hsa-miR-576-5p IL6R 0.940432050128373 6.90227595663302e-12 -0.0486500175487801 0.809389037083792 mirMAP -0.267701577746119 1.89976637762979e-05 NA NA NA hsa-miR-590-5p IL6R 0.763025362395968 3.65305892505623e-09 -0.0486500175487801 0.809389037083792 MirTarget;miRNATAP -0.238788817871458 0.000363136188095853 NA NA NA hsa-miR-93-5p IL6R 1.61042951896619 5.1280369606967e-24 -0.0486500175487801 0.809389037083792 mirMAP -0.320039043904434 7.06946338442526e-10 NA NA NA hsa-let-7a-3p IL6ST 0.0966652362351867 0.423761916840503 -1.51869334916695 1.31557122936242e-06 mirMAP -0.605535143379858 1.0917826994988e-07 NA NA NA hsa-miR-103a-3p IL6ST 0.556219385347418 1.55815736455067e-09 -1.51869334916695 1.31557122936242e-06 mirMAP -0.973603818072279 3.36638117985194e-11 NA NA NA hsa-miR-1301-3p IL6ST 2.13677668481885 6.11093268540831e-44 -1.51869334916695 1.31557122936242e-06 MirTarget -0.58793626001094 3.31919242589911e-13 NA NA NA hsa-miR-130a-3p IL6ST 0.67051191119964 4.89747518735144e-06 -1.51869334916695 1.31557122936242e-06 mirMAP;miRNATAP -0.778432540833983 9.76767360626368e-18 NA NA NA hsa-miR-130b-3p IL6ST 1.44628430084411 9.13980959861273e-24 -1.51869334916695 1.31557122936242e-06 miRNATAP -0.262815405468407 0.00426279409590801 NA NA NA hsa-miR-135b-5p IL6ST 1.5570143078477 4.60753610971455e-13 -1.51869334916695 1.31557122936242e-06 mirMAP -0.339927445218609 4.31801130394518e-08 NA NA NA hsa-miR-136-5p IL6ST -1.02992475853448 5.0914989178544e-07 -1.51869334916695 1.31557122936242e-06 MirTarget -0.188369461097369 0.00472438801680833 NA NA NA hsa-miR-146b-5p IL6ST 0.917975986853978 3.33749259316025e-09 -1.51869334916695 1.31557122936242e-06 miRanda -0.373405818750403 1.95043834914894e-05 NA NA NA hsa-miR-148b-5p IL6ST 1.1533193737265 7.26420964688337e-13 -1.51869334916695 1.31557122936242e-06 mirMAP -0.709611544072309 8.65761037142154e-18 NA NA NA hsa-miR-16-1-3p IL6ST 0.955017760172879 5.95379292601146e-11 -1.51869334916695 1.31557122936242e-06 mirMAP -0.586833968715718 1.73057482724902e-10 NA NA NA hsa-miR-16-2-3p IL6ST 1.1567130855258 1.01867256952189e-14 -1.51869334916695 1.31557122936242e-06 mirMAP -0.594677440464362 1.9429424710384e-11 NA NA NA hsa-miR-17-5p IL6ST 1.41924888736771 2.75805544953758e-18 -1.51869334916695 1.31557122936242e-06 TargetScan -0.821082089286594 1.02584240742469e-25 NA NA NA hsa-miR-181a-5p IL6ST 0.819060835827404 1.38616688310277e-13 -1.51869334916695 1.31557122936242e-06 mirMAP -0.541162792702852 9.11797464815492e-06 NA NA NA hsa-miR-181b-5p IL6ST 0.974255518824355 2.64876280203475e-16 -1.51869334916695 1.31557122936242e-06 mirMAP -0.554302417049339 8.22246620398204e-07 NA NA NA hsa-miR-182-5p IL6ST 1.15060905311096 6.25565852529946e-10 -1.51869334916695 1.31557122936242e-06 mirMAP -0.525037149871617 2.07843583316651e-13 NA NA NA hsa-miR-186-5p IL6ST 0.353452958261612 0.000145058448579496 -1.51869334916695 1.31557122936242e-06 MirTarget;mirMAP -0.864335576689512 4.75008512018144e-09 NA NA NA hsa-miR-19a-3p IL6ST 1.35800152353624 2.80940447111944e-12 -1.51869334916695 1.31557122936242e-06 mirMAP;miRNATAP -0.822825169574723 5.78845663510345e-37 NA NA NA hsa-miR-19b-3p IL6ST 0.538732279378089 0.000622008277870679 -1.51869334916695 1.31557122936242e-06 mirMAP;miRNATAP -0.995340441278119 7.41296068546637e-34 NA NA NA hsa-miR-200a-5p IL6ST 0.701063526850019 0.000188402923774663 -1.51869334916695 1.31557122936242e-06 mirMAP -0.245232440832052 0.000799215784070372 NA NA NA hsa-miR-200b-3p IL6ST 0.0717138787925347 0.682858087587209 -1.51869334916695 1.31557122936242e-06 TargetScan;mirMAP -0.323641087375277 3.80355716811575e-05 NA NA NA hsa-miR-200c-3p IL6ST 0.630251054099546 0.000131975031451555 -1.51869334916695 1.31557122936242e-06 mirMAP -0.278444437991617 0.000836033737071925 NA NA NA hsa-miR-20a-3p IL6ST 1.34885093664027 2.07697464119202e-12 -1.51869334916695 1.31557122936242e-06 mirMAP -0.570629185253329 7.60709527319589e-17 NA NA NA hsa-miR-21-5p IL6ST 1.62465922021121 3.44191300985109e-58 -1.51869334916695 1.31557122936242e-06 mirMAP -0.623399354714661 2.91681176043036e-07 NA NA NA hsa-miR-2355-3p IL6ST 1.58434563546762 4.06578912176206e-18 -1.51869334916695 1.31557122936242e-06 MirTarget;miRNATAP -0.343506435531798 2.29450541312614e-06 NA NA NA hsa-miR-24-1-5p IL6ST -0.0503110566834755 0.742860080224713 -1.51869334916695 1.31557122936242e-06 MirTarget -0.591920790093819 2.75158957697158e-11 NA NA NA hsa-miR-24-2-5p IL6ST 1.27293931700635 4.48240091510596e-15 -1.51869334916695 1.31557122936242e-06 MirTarget -0.704358381795938 1.70249686501093e-18 NA NA NA hsa-miR-26a-2-3p IL6ST -0.444498687388748 0.00325793861409413 -1.51869334916695 1.31557122936242e-06 MirTarget -0.447084976206471 8.56282690212163e-07 NA NA NA hsa-miR-26b-5p IL6ST -0.254478038884324 0.0285227763044636 -1.51869334916695 1.31557122936242e-06 mirMAP -0.673998378322072 1.17801995717703e-08 NA NA NA hsa-miR-28-3p IL6ST 0.459875450032895 3.47095927872566e-07 -1.51869334916695 1.31557122936242e-06 mirMAP -0.481949629291415 0.00165849773142838 NA NA NA hsa-miR-29a-5p IL6ST 0.323252792625584 0.0370417231222825 -1.51869334916695 1.31557122936242e-06 mirMAP -0.571439672316979 7.70795896885371e-11 NA NA NA hsa-miR-29b-1-5p IL6ST 1.39669186711325 4.36960953138935e-11 -1.51869334916695 1.31557122936242e-06 MirTarget -0.440583184630432 2.35980034841265e-12 NA NA NA hsa-miR-29b-2-5p IL6ST -0.502720326849742 0.000730448246894952 -1.51869334916695 1.31557122936242e-06 mirMAP -0.362341898982495 8.78684058757238e-05 NA NA NA hsa-miR-29b-3p IL6ST -0.110721443686039 0.511264554091106 -1.51869334916695 1.31557122936242e-06 mirMAP -0.582680606950154 4.46186068484861e-13 NA NA NA hsa-miR-301a-3p IL6ST 2.14132004241926 4.46255413526808e-25 -1.51869334916695 1.31557122936242e-06 mirMAP;miRNATAP -0.598925438144568 8.88677807846308e-23 NA NA NA hsa-miR-30b-5p IL6ST -0.400238605368173 0.00346540992719245 -1.51869334916695 1.31557122936242e-06 mirMAP -0.674549606392196 1.04873648791227e-11 NA NA NA hsa-miR-30c-5p IL6ST 0.021222006155897 0.886366656528128 -1.51869334916695 1.31557122936242e-06 mirMAP -0.847701624458618 4.24354216355747e-21 NA NA NA hsa-miR-335-3p IL6ST 0.336785882180547 0.0542446207938138 -1.51869334916695 1.31557122936242e-06 MirTarget;mirMAP -0.232392672186627 0.00326626720518081 NA NA NA hsa-miR-33a-5p IL6ST 1.12988965056352 3.35742517382153e-07 -1.51869334916695 1.31557122936242e-06 mirMAP -0.256846728499827 2.87952954870083e-05 NA NA NA hsa-miR-362-3p IL6ST -0.697212068252854 2.61718493418184e-06 -1.51869334916695 1.31557122936242e-06 PITA;miRanda;miRNATAP -0.261037815727869 0.00496230563734952 NA NA NA hsa-miR-362-5p IL6ST 0.41089772861323 0.0404254902071382 -1.51869334916695 1.31557122936242e-06 mirMAP -0.797241562749628 3.0262114369378e-35 NA NA NA hsa-miR-374a-3p IL6ST -0.299190081500425 0.00682975596757891 -1.51869334916695 1.31557122936242e-06 mirMAP -0.438021119926297 0.000474764576830278 NA NA NA hsa-miR-374b-3p IL6ST 0.425603499218802 0.00146686864653282 -1.51869334916695 1.31557122936242e-06 MirTarget -0.369615303967099 0.000357380675886101 NA NA NA hsa-miR-429 IL6ST 0.559451508722375 0.00563641638673083 -1.51869334916695 1.31557122936242e-06 PITA;miRanda;mirMAP;miRNATAP -0.46013865571223 6.33110367780873e-12 NA NA NA hsa-miR-454-3p IL6ST 1.54137391927201 4.15861570449376e-20 -1.51869334916695 1.31557122936242e-06 mirMAP;miRNATAP -0.875806631010846 9.07427453994692e-32 NA NA NA hsa-miR-455-5p IL6ST 1.408595672323 5.52039116456697e-22 -1.51869334916695 1.31557122936242e-06 miRanda -0.586982918251481 5.10095196700607e-11 NA NA NA hsa-miR-501-5p IL6ST 1.02806906860218 1.63456814370548e-09 -1.51869334916695 1.31557122936242e-06 mirMAP -0.629908978476 1.37181959933438e-15 NA NA NA hsa-miR-505-3p IL6ST 0.912823669571645 4.0549774967148e-13 -1.51869334916695 1.31557122936242e-06 MirTarget -0.725339041369227 7.05545219110427e-12 NA NA NA hsa-miR-532-5p IL6ST -0.021857649390892 0.830992272120134 -1.51869334916695 1.31557122936242e-06 PITA -0.431059681165621 0.00155536365883599 NA NA NA hsa-miR-576-5p IL6ST 0.940432050128373 6.90227595663302e-12 -1.51869334916695 1.31557122936242e-06 mirMAP -0.847898332656343 8.8491293130692e-19 NA NA NA hsa-miR-582-5p IL6ST -0.0366995972742474 0.821827119138923 -1.51869334916695 1.31557122936242e-06 mirMAP -0.285810924969582 0.000763113596881379 NA NA NA hsa-miR-589-3p IL6ST 1.59559692667315 6.2886410639161e-15 -1.51869334916695 1.31557122936242e-06 mirMAP -0.536004217582087 8.94462416885424e-16 NA NA NA hsa-miR-590-3p IL6ST 0.221436901462551 0.0965904764063157 -1.51869334916695 1.31557122936242e-06 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.293828684366189 0.00477387254418875 NA NA NA hsa-miR-590-5p IL6ST 0.763025362395968 3.65305892505623e-09 -1.51869334916695 1.31557122936242e-06 mirMAP -0.798370548940004 9.79796832812019e-15 NA NA NA hsa-miR-664a-3p IL6ST -0.256108763664991 0.0513188660751664 -1.51869334916695 1.31557122936242e-06 mirMAP -0.603364012635243 7.2140938785936e-09 NA NA NA hsa-miR-7-1-3p IL6ST 1.13646121619622 1.49823237535933e-14 -1.51869334916695 1.31557122936242e-06 mirMAP -0.446580100389377 8.1578232551768e-07 NA NA NA hsa-miR-708-3p IL6ST 1.32647174389322 4.87465491977979e-16 -1.51869334916695 1.31557122936242e-06 mirMAP -0.552836880179023 7.27203862400001e-12 NA NA NA hsa-miR-93-3p IL6ST 1.69225547123293 1.50964095575087e-25 -1.51869334916695 1.31557122936242e-06 MirTarget -0.613248834909938 1.06705489933022e-14 NA NA NA hsa-miR-129-5p IL7 -0.246329588499478 0.436451191224681 -0.629592654937052 0.00492986022645087 miRanda -0.10970529345841 0.000457314825869968 NA NA NA hsa-miR-335-3p IL7 0.336785882180547 0.0542446207938138 -0.629592654937052 0.00492986022645087 mirMAP -0.206361525279965 0.000216397820750568 NA NA NA hsa-miR-429 IL7 0.559451508722375 0.00563641638673083 -0.629592654937052 0.00492986022645087 miRanda -0.155273544396255 0.0012851075934239 NA NA NA hsa-miR-542-3p IL7 0.643308814904977 8.81635403230104e-07 -0.629592654937052 0.00492986022645087 miRanda -0.326534071162481 9.95714087036144e-06 NA NA NA hsa-miR-944 IL7 1.47323925060177 2.61626403984929e-13 -0.629592654937052 0.00492986022645087 mirMAP -0.200670712484546 2.10309547998525e-05 NA NA NA hsa-miR-125a-5p IL7R 0.215366061934933 0.119550904549401 0.946577743770938 0.00163962349331115 miRanda -0.369240270457518 0.000102693857245887 NA NA NA hsa-miR-199b-5p IL7R -1.08432682485992 7.68241801134089e-10 0.946577743770938 0.00163962349331115 miRanda -0.248813946329483 0.000687924969149623 NA NA NA hsa-miR-26b-5p IL7R -0.254478038884324 0.0285227763044636 0.946577743770938 0.00163962349331115 miRNAWalker2_validate -0.557748325284492 7.76166793562327e-07 NA NA NA hsa-miR-335-3p IL7R 0.336785882180547 0.0542446207938138 0.946577743770938 0.00163962349331115 mirMAP -0.254649741413612 0.000692573966156646 NA NA NA hsa-miR-501-5p IL7R 1.02806906860218 1.63456814370548e-09 0.946577743770938 0.00163962349331115 mirMAP -0.31997471243968 3.01541280296403e-05 NA NA NA hsa-miR-508-3p IL7R -1.16967833934103 0.00223596380485201 0.946577743770938 0.00163962349331115 mirMAP -0.122345045728517 0.00039549353993727 NA NA NA hsa-miR-576-5p IL7R 0.940432050128373 6.90227595663302e-12 0.946577743770938 0.00163962349331115 mirMAP -0.27454676626619 0.00357071376155502 NA NA NA hsa-miR-106b-5p IRF9 0.50378717276868 1.45412404526866e-05 0.935327841862363 2.83850764640282e-13 miRNAWalker2_validate -0.18555655928191 0.000149248743621145 NA NA NA hsa-miR-199a-5p IRF9 -0.364835768178638 0.0435119211101981 0.935327841862363 2.83850764640282e-13 miRanda -0.104123103816093 0.000969227209352264 NA NA NA hsa-miR-199b-5p IRF9 -1.08432682485992 7.68241801134089e-10 0.935327841862363 2.83850764640282e-13 miRanda -0.118080610477668 0.000204953468430156 NA NA NA hsa-miR-106a-5p JAK1 0.67978010057847 0.00221925869726092 -0.0679663395743342 0.461199949404594 MirTarget -0.100854682707181 1.31534376232975e-08 NA NA NA hsa-miR-106b-5p JAK1 0.50378717276868 1.45412404526866e-05 -0.0679663395743342 0.461199949404594 miRNAWalker2_validate;MirTarget -0.206914131837235 1.07605898502248e-09 NA NA NA hsa-miR-15b-5p JAK1 0.85315666454713 3.79816274836297e-12 -0.0679663395743342 0.461199949404594 miRNAWalker2_validate -0.203953135581548 1.01329642270345e-10 NA NA NA hsa-miR-17-5p JAK1 1.41924888736771 2.75805544953758e-18 -0.0679663395743342 0.461199949404594 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.23065214909774 3.99849330265778e-24 NA NA NA hsa-miR-20a-5p JAK1 1.1531986665452 1.02385132917958e-11 -0.0679663395743342 0.461199949404594 MirTarget -0.237250688217439 4.49970281277884e-27 NA NA NA hsa-miR-30b-5p JAK1 -0.400238605368173 0.00346540992719245 -0.0679663395743342 0.461199949404594 MirTarget -0.229823726204053 7.13348406434614e-16 NA NA NA hsa-miR-30c-5p JAK1 0.021222006155897 0.886366656528128 -0.0679663395743342 0.461199949404594 MirTarget -0.166665533010139 4.1183118110881e-10 NA NA NA hsa-miR-30d-5p JAK1 -0.38399848121878 0.000171129616944749 -0.0679663395743342 0.461199949404594 MirTarget -0.123392944276968 0.00168790112521357 NA NA NA hsa-miR-93-5p JAK1 1.61042951896619 5.1280369606967e-24 -0.0679663395743342 0.461199949404594 MirTarget;miRNATAP -0.237852807446343 3.18210459724217e-25 NA NA NA hsa-let-7a-3p JAK2 0.0966652362351867 0.423761916840503 -0.532127619081815 0.00142357520604873 mirMAP;miRNATAP -0.194508661520551 0.00134779157331669 NA NA NA hsa-miR-337-3p JAK2 -1.70091836051933 1.39844536073221e-13 -0.532127619081815 0.00142357520604873 PITA -0.145243586812907 2.24321528756252e-06 NA NA NA hsa-miR-495-3p JAK2 -1.47803501311999 6.88839745293927e-13 -0.532127619081815 0.00142357520604873 mirMAP -0.108487951118978 0.00176426227457955 NA NA NA hsa-miR-130b-5p LEPR 1.77265255049999 1.43627774829684e-29 -1.23632756290307 6.52585817564084e-12 mirMAP -0.366408905309498 6.64222118904346e-15 NA NA NA hsa-miR-146b-5p LEPR 0.917975986853978 3.33749259316025e-09 -1.23632756290307 6.52585817564084e-12 miRanda -0.201028675307849 7.42465041124716e-05 NA NA NA hsa-miR-16-1-3p LEPR 0.955017760172879 5.95379292601146e-11 -1.23632756290307 6.52585817564084e-12 mirMAP -0.424569074585509 7.59458442417996e-16 NA NA NA hsa-miR-16-2-3p LEPR 1.1567130855258 1.01867256952189e-14 -1.23632756290307 6.52585817564084e-12 mirMAP -0.481752699668289 8.9418747733818e-22 NA NA NA hsa-miR-29a-5p LEPR 0.323252792625584 0.0370417231222825 -1.23632756290307 6.52585817564084e-12 mirMAP -0.186762969622628 0.000296339307632955 NA NA NA hsa-miR-320a LEPR 0.801356001806321 4.91397101474502e-09 -1.23632756290307 6.52585817564084e-12 miRanda -0.367409773689157 1.05828428033316e-10 NA NA NA hsa-miR-320b LEPR 1.23473838180754 3.04337566045537e-14 -1.23632756290307 6.52585817564084e-12 miRanda -0.254652687118693 8.90615499842712e-08 NA NA NA hsa-miR-335-3p LEPR 0.336785882180547 0.0542446207938138 -1.23632756290307 6.52585817564084e-12 mirMAP -0.229117635164551 4.55340343505293e-07 NA NA NA hsa-miR-33a-3p LEPR 0.20371038027126 0.212335697664505 -1.23632756290307 6.52585817564084e-12 mirMAP -0.157730107180504 0.00154680295630205 NA NA NA hsa-miR-342-3p LEPR 0.99756868977753 9.28499866272332e-10 -1.23632756290307 6.52585817564084e-12 miRanda -0.310112525787324 7.50969112704326e-11 NA NA NA hsa-miR-429 LEPR 0.559451508722375 0.00563641638673083 -1.23632756290307 6.52585817564084e-12 miRanda;miRNATAP -0.228520340757734 4.83256442060387e-09 NA NA NA hsa-miR-576-5p LEPR 0.940432050128373 6.90227595663302e-12 -1.23632756290307 6.52585817564084e-12 PITA -0.303399722899237 9.46709088745811e-08 NA NA NA hsa-miR-590-3p LEPR 0.221436901462551 0.0965904764063157 -1.23632756290307 6.52585817564084e-12 miRanda;mirMAP -0.238337511058488 7.36238786911111e-05 NA NA NA hsa-miR-590-5p LEPR 0.763025362395968 3.65305892505623e-09 -1.23632756290307 6.52585817564084e-12 miRanda -0.425786146984413 1.32121105893205e-12 NA NA NA hsa-miR-660-5p LEPR -0.202705992887645 0.101093376073573 -1.23632756290307 6.52585817564084e-12 MirTarget -0.297024853033849 4.44550079358634e-06 NA NA NA hsa-miR-7-1-3p LEPR 1.13646121619622 1.49823237535933e-14 -1.23632756290307 6.52585817564084e-12 mirMAP -0.362453329896546 2.80823726773109e-12 NA NA NA hsa-miR-877-5p LEPR 1.97571572671705 2.0032239372269e-19 -1.23632756290307 6.52585817564084e-12 miRNAWalker2_validate -0.109760948091728 0.00388159298722456 NA NA NA hsa-miR-141-3p LIF 0.730011517758706 0.000120338355004032 0.439805187845851 0.0935285339100472 mirMAP -0.185001739336313 0.00199151459650277 NA NA NA hsa-miR-150-5p LIF -0.243749814009231 0.331546276920338 0.439805187845851 0.0935285339100472 mirMAP -0.117558001604128 0.00985201609828022 NA NA NA hsa-miR-193a-3p LIF 0.22120710726779 0.111827069464729 0.439805187845851 0.0935285339100472 miRanda -0.284976295742279 0.000534412771594283 NA NA NA hsa-miR-200a-3p LIF 0.607140814457753 0.00289840524858752 0.439805187845851 0.0935285339100472 mirMAP -0.185174624155247 0.000908723932076356 NA NA NA hsa-miR-205-3p LIF 1.2960640797621 5.80786479909147e-11 0.439805187845851 0.0935285339100472 mirMAP -0.232087666643773 3.90627052969808e-05 NA NA NA hsa-miR-224-5p LIF 1.94534596857416 1.88348779207332e-19 0.439805187845851 0.0935285339100472 mirMAP -0.162095349125972 0.00148123516080369 NA NA NA hsa-let-7a-3p LIFR 0.0966652362351867 0.423761916840503 -1.51901651874208 7.76076300641371e-10 mirMAP -0.348197391725037 0.000127621611222784 NA NA NA hsa-miR-182-5p LIFR 1.15060905311096 6.25565852529946e-10 -1.51901651874208 7.76076300641371e-10 mirMAP -0.205527638227969 0.000371891331095496 NA NA NA hsa-miR-19a-3p LIFR 1.35800152353624 2.80940447111944e-12 -1.51901651874208 7.76076300641371e-10 mirMAP -0.419293873202406 6.13216648014511e-15 NA NA NA hsa-miR-19b-3p LIFR 0.538732279378089 0.000622008277870679 -1.51901651874208 7.76076300641371e-10 mirMAP -0.447919475112783 5.15533353632929e-11 NA NA NA hsa-miR-203a-3p LIFR 0.0441399794719697 0.880456392176704 -1.51901651874208 7.76076300641371e-10 MirTarget -0.362080472937265 3.03636114029239e-24 NA NA NA hsa-miR-205-3p LIFR 1.2960640797621 5.80786479909147e-11 -1.51901651874208 7.76076300641371e-10 mirMAP -0.306589797021324 1.08788929349536e-08 NA NA NA hsa-miR-205-5p LIFR 1.50759485376634 2.0003886738248e-16 -1.51901651874208 7.76076300641371e-10 mirMAP -0.457383210987351 4.86429728104602e-16 NA NA NA hsa-miR-21-5p LIFR 1.62465922021121 3.44191300985109e-58 -1.51901651874208 7.76076300641371e-10 miRNAWalker2_validate -0.443330293378903 4.35388420605488e-06 NA NA NA hsa-miR-221-3p LIFR 0.410625614724387 0.000741090075261272 -1.51901651874208 7.76076300641371e-10 miRNATAP -0.332807994036584 0.000210810302523901 NA NA NA hsa-miR-222-3p LIFR 1.08197052578759 2.32604040301699e-14 -1.51901651874208 7.76076300641371e-10 miRNATAP -0.472564867410622 1.98660494575808e-10 NA NA NA hsa-miR-224-3p LIFR 0.502645536188015 0.0081142387260641 -1.51901651874208 7.76076300641371e-10 mirMAP -0.200968991271485 0.000513990914683148 NA NA NA hsa-miR-27a-3p LIFR 0.348456440505425 0.00126682892514312 -1.51901651874208 7.76076300641371e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.506929361704378 4.98141971579838e-07 NA NA NA hsa-miR-29b-1-5p LIFR 1.39669186711325 4.36960953138935e-11 -1.51901651874208 7.76076300641371e-10 mirMAP -0.272503500963374 5.8122021334744e-08 NA NA NA hsa-miR-429 LIFR 0.559451508722375 0.00563641638673083 -1.51901651874208 7.76076300641371e-10 miRanda -0.231182787388009 1.7057229879373e-05 NA NA NA hsa-miR-500a-5p LIFR 0.675401699376111 8.24389004707854e-05 -1.51901651874208 7.76076300641371e-10 mirMAP -0.271499524342483 1.72770702911245e-05 NA NA NA hsa-miR-590-5p LIFR 0.763025362395968 3.65305892505623e-09 -1.51901651874208 7.76076300641371e-10 PITA;miRNATAP -0.353687662126009 2.18286736693477e-05 NA NA NA hsa-miR-708-3p LIFR 1.32647174389322 4.87465491977979e-16 -1.51901651874208 7.76076300641371e-10 mirMAP -0.303532259202886 2.6745223190057e-06 NA NA NA hsa-miR-944 LIFR 1.47323925060177 2.61626403984929e-13 -1.51901651874208 7.76076300641371e-10 mirMAP -0.325703264383451 4.62760010921302e-10 NA NA NA hsa-miR-96-5p LIFR 1.42326703011157 4.39736150032373e-14 -1.51901651874208 7.76076300641371e-10 mirMAP -0.302065128766525 7.04330721849415e-08 NA NA NA hsa-miR-28-5p MPL -0.026996999089909 0.733047113251652 -0.694047812007921 1.70807667713998e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.300352099456734 0.000244400759188015 NA NA NA hsa-miR-625-5p MPL 0.346770617079364 0.02860843739549 -0.694047812007921 1.70807667713998e-06 MirTarget -0.115261993323584 0.00446465274273534 NA NA NA hsa-miR-708-3p MPL 1.32647174389322 4.87465491977979e-16 -0.694047812007921 1.70807667713998e-06 miRNAWalker2_validate;miRTarBase -0.170668146439514 5.96291404050896e-06 NA NA NA hsa-miR-708-5p MPL 1.54207894190626 2.2887257992285e-19 -0.694047812007921 1.70807667713998e-06 MirTarget -0.170318901132427 1.77311758650268e-06 NA NA NA hsa-let-7c-5p MYC -2.07953368242668 3.46048888391218e-23 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.107421906050131 0.000103545158346461 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-34a-5p MYC -0.117372471043915 0.364001947180738 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.157674637324898 0.000854501792660625 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-139-5p OSMR -1.46099200329485 7.85040381494472e-22 0.439137012220466 0.0175237971977372 miRanda -0.136006703230251 0.00760082728029919 NA NA NA hsa-miR-200b-3p OSMR 0.0717138787925347 0.682858087587209 0.439137012220466 0.0175237971977372 TargetScan -0.196859758190871 1.73370356000614e-05 NA NA NA hsa-miR-335-5p OSMR -1.17227779671552 1.49282618530733e-10 0.439137012220466 0.0175237971977372 miRNAWalker2_validate -0.13269130640974 0.0021678691879024 NA NA NA hsa-miR-362-3p OSMR -0.697212068252854 2.61718493418184e-06 0.439137012220466 0.0175237971977372 miRanda -0.211575946960926 8.99717303090219e-05 NA NA NA hsa-miR-374a-5p OSMR -0.621903385111545 6.61791773205282e-12 0.439137012220466 0.0175237971977372 mirMAP -0.297593268699733 0.000730239600726995 NA NA NA hsa-miR-374b-5p OSMR -0.288413933608091 0.0041474558664058 0.439137012220466 0.0175237971977372 mirMAP -0.384562031028341 1.59752732401194e-06 NA NA NA hsa-miR-429 OSMR 0.559451508722375 0.00563641638673083 0.439137012220466 0.0175237971977372 miRanda;miRNATAP -0.193727874388202 9.39401488930102e-07 NA NA NA hsa-miR-495-3p OSMR -1.47803501311999 6.88839745293927e-13 0.439137012220466 0.0175237971977372 mirMAP -0.110934217419729 0.00385889172384574 NA NA NA hsa-miR-320a PIAS1 0.801356001806321 4.91397101474502e-09 -0.274714893312564 0.000577807035569923 miRanda -0.110550856860479 9.57424251339952e-06 NA NA NA hsa-miR-342-3p PIAS1 0.99756868977753 9.28499866272332e-10 -0.274714893312564 0.000577807035569923 miRanda -0.100321762565677 1.55736875390074e-06 NA NA NA hsa-miR-125a-3p PIAS2 0.116035800853173 0.444825559956959 -0.298114451345536 0.00835930210237724 miRanda -0.121091180792833 0.000191617032222155 NA NA NA hsa-miR-181a-5p PIAS2 0.819060835827404 1.38616688310277e-13 -0.298114451345536 0.00835930210237724 mirMAP -0.217461309825504 5.33955996241831e-07 NA NA NA hsa-miR-181b-5p PIAS2 0.974255518824355 2.64876280203475e-16 -0.298114451345536 0.00835930210237724 mirMAP -0.296994333583216 5.37358630442535e-14 NA NA NA hsa-miR-193a-3p PIAS2 0.22120710726779 0.111827069464729 -0.298114451345536 0.00835930210237724 MirTarget -0.181789192940028 2.47033000241501e-07 NA NA NA hsa-miR-193b-3p PIAS2 1.72788400801602 3.0722151264559e-21 -0.298114451345536 0.00835930210237724 MirTarget -0.252569414698185 2.06519063641978e-24 NA NA NA hsa-miR-424-5p PIAS2 1.48125289532143 9.10372985713165e-19 -0.298114451345536 0.00835930210237724 MirTarget -0.147988066607971 1.49381729857385e-07 NA NA NA hsa-miR-576-5p PIAS2 0.940432050128373 6.90227595663302e-12 -0.298114451345536 0.00835930210237724 mirMAP -0.138297099079441 8.51235197377772e-05 NA NA NA hsa-miR-146b-5p PIK3CA 0.917975986853978 3.33749259316025e-09 0.474083948253385 0.000138354293457267 mirMAP -0.148623698754488 1.59224953432472e-05 NA NA NA hsa-miR-17-5p PIK3CA 1.41924888736771 2.75805544953758e-18 0.474083948253385 0.000138354293457267 miRNAWalker2_validate -0.121128691188414 0.000174670602072176 NA NA NA hsa-miR-186-5p PIK3CA 0.353452958261612 0.000145058448579496 0.474083948253385 0.000138354293457267 mirMAP -0.297473635549502 3.47602075640407e-07 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.39669186711325 4.36960953138935e-11 0.474083948253385 0.000138354293457267 mirMAP -0.137606426566373 3.59722935161776e-08 NA NA NA hsa-miR-320a PIK3CA 0.801356001806321 4.91397101474502e-09 0.474083948253385 0.000138354293457267 miRanda -0.175899873415021 6.70887782534591e-06 NA NA NA hsa-miR-339-5p PIK3CA 1.07771430326938 2.45772601859307e-09 0.474083948253385 0.000138354293457267 miRanda -0.140087795917754 2.01352800438963e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.288413933608091 0.0041474558664058 0.474083948253385 0.000138354293457267 mirMAP -0.251699909641235 3.33151190183606e-06 NA NA NA hsa-miR-501-5p PIK3CA 1.02806906860218 1.63456814370548e-09 0.474083948253385 0.000138354293457267 mirMAP -0.119863788285527 0.00016396438241956 NA NA NA hsa-miR-576-5p PIK3CA 0.940432050128373 6.90227595663302e-12 0.474083948253385 0.000138354293457267 PITA -0.211172584428942 4.54724446596707e-08 NA NA NA hsa-miR-582-3p PIK3CA -0.248056267546012 0.143798829508405 0.474083948253385 0.000138354293457267 miRNATAP -0.112384075179319 0.000457171976884077 NA NA NA hsa-miR-590-3p PIK3CA 0.221436901462551 0.0965904764063157 0.474083948253385 0.000138354293457267 miRanda;mirMAP -0.123785866799948 0.00253231685417896 NA NA NA hsa-miR-590-5p PIK3CA 0.763025362395968 3.65305892505623e-09 0.474083948253385 0.000138354293457267 miRanda -0.137459565446424 0.000946581823458912 NA NA NA hsa-miR-130a-3p PIK3CB 0.67051191119964 4.89747518735144e-06 -0.0830016803916331 0.377605728994098 miRNATAP -0.116910694940516 2.17993945184649e-05 NA NA NA hsa-miR-455-5p PIK3CB 1.408595672323 5.52039116456697e-22 -0.0830016803916331 0.377605728994098 miRNATAP -0.112305249746916 2.65965267643942e-05 NA NA NA hsa-miR-1468-5p PIK3CD -1.11814152104975 9.8203170781489e-10 1.09936669850841 6.53933580961931e-14 MirTarget -0.190058878065479 5.39186071979921e-08 NA NA NA hsa-miR-199a-5p PIK3CD -0.364835768178638 0.0435119211101981 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.10392905863127 0.00413232021656056 NA NA NA hsa-miR-199b-5p PIK3CD -1.08432682485992 7.68241801134089e-10 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.174865940346935 1.46520648745166e-06 NA NA NA hsa-miR-29c-3p PIK3CD -2.08166260448948 8.3238369390898e-24 1.09936669850841 6.53933580961931e-14 mirMAP -0.123728555182124 3.91761687692399e-05 NA NA NA hsa-miR-30a-5p PIK3CD -1.79779915425811 1.93360169837799e-26 1.09936669850841 6.53933580961931e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.215181764255274 3.32715363881856e-09 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -0.338530747940815 0.0223424741180399 1.09936669850841 6.53933580961931e-14 MirTarget -0.212653512510377 1.36776424072036e-06 NA NA NA hsa-miR-30b-5p PIK3CD -0.400238605368173 0.00346540992719245 1.09936669850841 6.53933580961931e-14 MirTarget -0.248889126985861 1.5426059915817e-07 NA NA NA hsa-miR-30d-5p PIK3CD -0.38399848121878 0.000171129616944749 1.09936669850841 6.53933580961931e-14 MirTarget;miRNATAP -0.328266173808776 2.63776877258142e-07 NA NA NA hsa-miR-30e-5p PIK3CD -1.02114836019762 6.81961221797866e-17 1.09936669850841 6.53933580961931e-14 MirTarget -0.209324939899388 5.5934958220938e-05 NA NA NA hsa-miR-126-3p PIK3CG 0.0487843863772834 0.730130847436008 0.00752271010659966 0.976960758681749 miRTarBase -0.269414114814437 0.000806379873030215 NA NA NA hsa-miR-26b-5p PIK3CG -0.254478038884324 0.0285227763044636 0.00752271010659966 0.976960758681749 miRNAWalker2_validate -0.345718989912845 0.00041292580999725 NA NA NA hsa-miR-335-3p PIK3CG 0.336785882180547 0.0542446207938138 0.00752271010659966 0.976960758681749 mirMAP -0.20863783184887 0.00127495716846541 NA NA NA hsa-miR-3607-3p PIK3CG 1.01377165357363 9.13355519701165e-05 0.00752271010659966 0.976960758681749 mirMAP -0.153979618634459 0.000387199003031277 NA NA NA hsa-miR-103a-3p PIK3R1 0.556219385347418 1.55815736455067e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.399035342845615 3.61390305129075e-07 NA NA NA hsa-miR-1301-3p PIK3R1 2.13677668481885 6.11093268540831e-44 -1.21900359295309 1.01203266762174e-13 MirTarget -0.223004793710498 2.5912949051374e-07 NA NA NA hsa-miR-15a-5p PIK3R1 0.783550182002274 2.60699595655907e-11 -1.21900359295309 1.01203266762174e-13 MirTarget -0.385662977903284 1.7816116353762e-10 NA NA NA hsa-miR-15b-5p PIK3R1 0.85315666454713 3.79816274836297e-12 -1.21900359295309 1.01203266762174e-13 MirTarget -0.228618884263194 9.01523017331239e-05 NA NA NA hsa-miR-16-2-3p PIK3R1 1.1567130855258 1.01867256952189e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.316425483424084 1.52783996282521e-11 NA NA NA hsa-miR-17-5p PIK3R1 1.41924888736771 2.75805544953758e-18 -1.21900359295309 1.01203266762174e-13 MirTarget;TargetScan;miRNATAP -0.463182517340129 2.13936557580788e-29 NA NA NA hsa-miR-182-5p PIK3R1 1.15060905311096 6.25565852529946e-10 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.244940881967473 1.25505363832818e-10 NA NA NA hsa-miR-185-5p PIK3R1 0.675225177054909 1.84953949190805e-13 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.284475955115523 0.000292942961891748 NA NA NA hsa-miR-186-5p PIK3R1 0.353452958261612 0.000145058448579496 -1.21900359295309 1.01203266762174e-13 mirMAP -0.319700116089251 4.98623038012755e-05 NA NA NA hsa-miR-188-5p PIK3R1 0.559328953885106 0.000430338888594543 -1.21900359295309 1.01203266762174e-13 MirTarget -0.160342440576419 0.000495444736297818 NA NA NA hsa-miR-200b-3p PIK3R1 0.0717138787925347 0.682858087587209 -1.21900359295309 1.01203266762174e-13 mirMAP -0.132316541375546 0.00152319590606084 NA NA NA hsa-miR-200c-3p PIK3R1 0.630251054099546 0.000131975031451555 -1.21900359295309 1.01203266762174e-13 mirMAP -0.165950070298812 0.000166005249225027 NA NA NA hsa-miR-20a-5p PIK3R1 1.1531986665452 1.02385132917958e-11 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.414035689070749 1.37700726304578e-24 NA NA NA hsa-miR-21-5p PIK3R1 1.62465922021121 3.44191300985109e-58 -1.21900359295309 1.01203266762174e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.347959293536401 6.14239978504788e-08 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.706731861922839 3.44318705980007e-07 -1.21900359295309 1.01203266762174e-13 mirMAP -0.186341013334501 0.000362689778770643 NA NA NA hsa-miR-222-3p PIK3R1 1.08197052578759 2.32604040301699e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.324361920211689 6.16230355082933e-11 NA NA NA hsa-miR-224-3p PIK3R1 0.502645536188015 0.0081142387260641 -1.21900359295309 1.01203266762174e-13 mirMAP -0.120566945623901 0.00184832047796862 NA NA NA hsa-miR-29b-3p PIK3R1 -0.110721443686039 0.511264554091106 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.121645516169564 0.00518596779631768 NA NA NA hsa-miR-320a PIK3R1 0.801356001806321 4.91397101474502e-09 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.225199809648846 1.82460995490226e-05 NA NA NA hsa-miR-320b PIK3R1 1.23473838180754 3.04337566045537e-14 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.134920857869101 0.00211752860446172 NA NA NA hsa-miR-324-3p PIK3R1 0.867391246413545 3.63808540490361e-10 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.177541714088148 0.000648957139596168 NA NA NA hsa-miR-424-5p PIK3R1 1.48125289532143 9.10372985713165e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.194732317900543 3.45343462326547e-06 NA NA NA hsa-miR-429 PIK3R1 0.559451508722375 0.00563641638673083 -1.21900359295309 1.01203266762174e-13 mirMAP;miRNATAP -0.216477715044302 1.22729945836841e-09 NA NA NA hsa-miR-450b-5p PIK3R1 1.25529820885833 1.18847120528666e-15 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.182288230735551 5.59609717066614e-05 NA NA NA hsa-miR-455-3p PIK3R1 2.68574446868387 4.28975903022818e-42 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.231037194203872 4.67534308068801e-12 NA NA NA hsa-miR-584-5p PIK3R1 0.458655788667031 0.0421764547676754 -1.21900359295309 1.01203266762174e-13 mirMAP -0.158511510137748 8.00515680759562e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.59559692667315 6.2886410639161e-15 -1.21900359295309 1.01203266762174e-13 mirMAP -0.276889190811914 4.76785574986701e-15 NA NA NA hsa-miR-590-3p PIK3R1 0.221436901462551 0.0965904764063157 -1.21900359295309 1.01203266762174e-13 miRanda;mirMAP -0.158050349961081 0.00414021352655968 NA NA NA hsa-miR-590-5p PIK3R1 0.763025362395968 3.65305892505623e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRanda;miRNATAP -0.424270969807281 7.70480985025408e-15 NA NA NA hsa-miR-629-3p PIK3R1 1.43262037314105 2.37092217984413e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.192452582760208 1.31715256298262e-05 NA NA NA hsa-miR-93-5p PIK3R1 1.61042951896619 5.1280369606967e-24 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.348791344759735 3.1302460531533e-16 NA NA NA hsa-miR-96-5p PIK3R1 1.42326703011157 4.39736150032373e-14 -1.21900359295309 1.01203266762174e-13 TargetScan;miRNATAP -0.310953673912161 2.47412618125618e-17 NA NA NA hsa-miR-18a-3p PIK3R3 1.82583720936229 7.51297960972179e-19 -0.129019532966171 0.451055967559973 miRNAWalker2_validate -0.103240638013552 0.00398585116122596 NA NA NA hsa-miR-19a-3p PIK3R3 1.35800152353624 2.80940447111944e-12 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.153374017381767 4.01568767526052e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.538732279378089 0.000622008277870679 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.12996294371586 0.00591308278368021 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.39669186711325 4.36960953138935e-11 -0.129019532966171 0.451055967559973 mirMAP -0.137442753028623 6.48468495867568e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.446833934952926 0.00233857759218299 -0.129019532966171 0.451055967559973 MirTarget -0.431569400997508 1.46400297130903e-18 NA NA NA hsa-miR-369-3p PIK3R3 -1.2344419076994 2.66882944171146e-10 -0.129019532966171 0.451055967559973 PITA -0.105890967034452 0.00482950119317686 NA NA NA hsa-miR-589-3p PIK3R3 1.59559692667315 6.2886410639161e-15 -0.129019532966171 0.451055967559973 mirMAP -0.138465461387875 0.000168219132587265 NA NA NA hsa-miR-182-5p PIK3R5 1.15060905311096 6.25565852529946e-10 0.15902332125267 0.38685549407615 MirTarget -0.236115638976413 1.63099014479463e-08 NA NA NA hsa-miR-18a-3p PIK3R5 1.82583720936229 7.51297960972179e-19 0.15902332125267 0.38685549407615 MirTarget -0.160296162742907 2.89078394864452e-05 NA NA NA hsa-miR-944 PIK3R5 1.47323925060177 2.61626403984929e-13 0.15902332125267 0.38685549407615 mirMAP -0.211607874388069 3.42384043348289e-08 NA NA NA hsa-let-7g-3p PIM1 0.637019243992294 0.000204623048574065 -0.815643682468393 4.99206065625855e-08 miRNATAP -0.116005928511672 0.0024474310807403 NA NA NA hsa-miR-15b-5p PIM1 0.85315666454713 3.79816274836297e-12 -0.815643682468393 4.99206065625855e-08 miRNATAP -0.312940434356392 1.95391006606312e-09 NA NA NA hsa-miR-16-5p PIM1 0.521122945828175 1.40561786410572e-06 -0.815643682468393 4.99206065625855e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.272436108968727 6.97069329054522e-06 NA NA NA hsa-miR-183-5p PIM1 1.4313129319945 6.25230916431996e-14 -0.815643682468393 4.99206065625855e-08 miRNATAP -0.169254726551999 4.21659815035567e-07 NA NA NA hsa-miR-192-5p PIM1 0.380924502586635 0.00986961967409205 -0.815643682468393 4.99206065625855e-08 miRNAWalker2_validate -0.240860087570636 5.35262386525187e-08 NA NA NA hsa-miR-215-5p PIM1 -0.757663683237828 5.72998183244808e-05 -0.815643682468393 4.99206065625855e-08 miRNAWalker2_validate -0.131386916194076 0.000170527547030233 NA NA NA hsa-miR-331-3p PIM1 0.906385914819361 4.27653809739414e-11 -0.815643682468393 4.99206065625855e-08 miRNATAP -0.18760376295581 6.75604634719648e-05 NA NA NA hsa-miR-335-5p PIM1 -1.17227779671552 1.49282618530733e-10 -0.815643682468393 4.99206065625855e-08 miRNAWalker2_validate -0.195523675647536 2.42296190296181e-08 NA NA NA hsa-miR-339-5p PIM1 1.07771430326938 2.45772601859307e-09 -0.815643682468393 4.99206065625855e-08 miRanda -0.111943318959126 0.00184871073936291 NA NA NA hsa-miR-33b-5p PIM1 0.681845193600723 0.00407790722487864 -0.815643682468393 4.99206065625855e-08 miRNATAP -0.14419423362917 3.54166098939661e-07 NA NA NA hsa-miR-429 PIM1 0.559451508722375 0.00563641638673083 -0.815643682468393 4.99206065625855e-08 miRNATAP -0.156742534478117 1.25109656089437e-06 NA NA NA hsa-miR-532-3p PIM1 0.80240056676907 1.08989551712617e-09 -0.815643682468393 4.99206065625855e-08 miRNATAP -0.218347601938449 9.27412963287818e-06 NA NA NA hsa-miR-769-3p PIM1 0.89886491506181 2.21711828717073e-08 -0.815643682468393 4.99206065625855e-08 PITA -0.196657481715202 1.29156629751144e-06 NA NA NA hsa-let-7a-3p PRLR 0.0966652362351867 0.423761916840503 -1.30787264357825 0.000471474755219158 mirMAP -0.512701701055818 0.000164195588073901 NA NA NA hsa-let-7d-5p PRLR 0.481757661442508 3.66030810124939e-07 -1.30787264357825 0.000471474755219158 miRNATAP -0.480531634644174 0.00546237376205416 NA NA NA hsa-let-7f-1-3p PRLR 0.700374242293247 8.65000484720084e-08 -1.30787264357825 0.000471474755219158 mirMAP -0.433240907145624 0.000472931993455816 NA NA NA hsa-miR-103a-2-5p PRLR 1.37988337975616 6.74852943995612e-08 -1.30787264357825 0.000471474755219158 mirMAP -0.294265559991193 1.78344449895191e-05 NA NA NA hsa-miR-130a-3p PRLR 0.67051191119964 4.89747518735144e-06 -1.30787264357825 0.000471474755219158 mirMAP -0.524104230206842 1.97264872216105e-06 NA NA NA hsa-miR-130b-3p PRLR 1.44628430084411 9.13980959861273e-24 -1.30787264357825 0.000471474755219158 mirMAP -0.359905948871644 0.000944686290777868 NA NA NA hsa-miR-15b-3p PRLR 1.05020782493504 6.38723677324836e-14 -1.30787264357825 0.000471474755219158 mirMAP -0.399837324622169 0.000462570490348866 NA NA NA hsa-miR-16-1-3p PRLR 0.955017760172879 5.95379292601146e-11 -1.30787264357825 0.000471474755219158 mirMAP -0.336245037970807 0.0023652776899924 NA NA NA hsa-miR-182-5p PRLR 1.15060905311096 6.25565852529946e-10 -1.30787264357825 0.000471474755219158 miRNATAP -0.249382765635961 0.00397861414708402 NA NA NA hsa-miR-196b-5p PRLR 3.78958266598891 1.12771732893771e-44 -1.30787264357825 0.000471474755219158 miRNATAP -0.201137841350913 0.000269777553933088 NA NA NA hsa-miR-19b-1-5p PRLR 0.757034032029085 2.99828133413343e-07 -1.30787264357825 0.000471474755219158 mirMAP -0.600855059067166 3.28773829877233e-08 NA NA NA hsa-miR-20a-3p PRLR 1.34885093664027 2.07697464119202e-12 -1.30787264357825 0.000471474755219158 mirMAP -0.436935799896661 1.2825302457752e-07 NA NA NA hsa-miR-26a-2-3p PRLR -0.444498687388748 0.00325793861409413 -1.30787264357825 0.000471474755219158 mirMAP -0.319449331019102 0.00322643735843453 NA NA NA hsa-miR-29a-5p PRLR 0.323252792625584 0.0370417231222825 -1.30787264357825 0.000471474755219158 mirMAP -0.368627642456112 0.00048176748385086 NA NA NA hsa-miR-301a-3p PRLR 2.14132004241926 4.46255413526808e-25 -1.30787264357825 0.000471474755219158 mirMAP -0.263803774296363 0.000450204776519736 NA NA NA hsa-miR-320a PRLR 0.801356001806321 4.91397101474502e-09 -1.30787264357825 0.000471474755219158 miRanda -0.523459199972559 8.48081441802328e-06 NA NA NA hsa-miR-320b PRLR 1.23473838180754 3.04337566045537e-14 -1.30787264357825 0.000471474755219158 miRanda -0.334787456285682 0.000649581616061883 NA NA NA hsa-miR-374a-3p PRLR -0.299190081500425 0.00682975596757891 -1.30787264357825 0.000471474755219158 mirMAP -0.41433744454592 0.00538517607267949 NA NA NA hsa-miR-374b-3p PRLR 0.425603499218802 0.00146686864653282 -1.30787264357825 0.000471474755219158 mirMAP -0.518216948701422 2.30511112828655e-05 NA NA NA hsa-miR-454-3p PRLR 1.54137391927201 4.15861570449376e-20 -1.30787264357825 0.000471474755219158 mirMAP -0.413431991391847 9.84309936266268e-06 NA NA NA hsa-miR-501-5p PRLR 1.02806906860218 1.63456814370548e-09 -1.30787264357825 0.000471474755219158 mirMAP -0.263528034801935 0.00604534975627035 NA NA NA hsa-miR-576-5p PRLR 0.940432050128373 6.90227595663302e-12 -1.30787264357825 0.000471474755219158 mirMAP -0.477474519090289 4.43457828795712e-05 NA NA NA hsa-miR-582-5p PRLR -0.0366995972742474 0.821827119138923 -1.30787264357825 0.000471474755219158 PITA -0.398109988033518 7.37537201947536e-05 NA NA NA hsa-miR-589-3p PRLR 1.59559692667315 6.2886410639161e-15 -1.30787264357825 0.000471474755219158 mirMAP -0.338642940521925 2.77063739189816e-05 NA NA NA hsa-miR-7-1-3p PRLR 1.13646121619622 1.49823237535933e-14 -1.30787264357825 0.000471474755219158 mirMAP -0.60138070070372 1.88226549150637e-08 NA NA NA hsa-miR-9-5p PRLR 1.65694862043766 2.08325802567323e-05 -1.30787264357825 0.000471474755219158 miRNATAP -0.110968323939938 0.00776842585282018 NA NA NA hsa-miR-944 PRLR 1.47323925060177 2.61626403984929e-13 -1.30787264357825 0.000471474755219158 mirMAP -0.422976307830314 7.35863725072358e-08 NA NA NA hsa-miR-96-5p PRLR 1.42326703011157 4.39736150032373e-14 -1.30787264357825 0.000471474755219158 miRNATAP -0.32127974264967 0.000142163243405471 NA NA NA hsa-miR-181a-5p PTPN11 0.819060835827404 1.38616688310277e-13 -0.0515826939037778 0.576869711205509 miRNAWalker2_validate;miRTarBase -0.161608190801894 4.96220269355183e-06 NA NA NA hsa-miR-186-5p PTPN11 0.353452958261612 0.000145058448579496 -0.0515826939037778 0.576869711205509 mirMAP -0.12504435483559 0.00395247157448723 NA NA NA hsa-miR-19a-3p PTPN11 1.35800152353624 2.80940447111944e-12 -0.0515826939037778 0.576869711205509 mirMAP -0.104810580196544 1.63971779276308e-07 NA NA NA hsa-miR-19b-3p PTPN11 0.538732279378089 0.000622008277870679 -0.0515826939037778 0.576869711205509 mirMAP -0.142907034248953 1.30234193411386e-08 NA NA NA hsa-miR-30d-3p PTPN11 -0.577371911152798 2.02950840095287e-06 -0.0515826939037778 0.576869711205509 mirMAP -0.103411088631455 0.00168252066916046 NA NA NA hsa-miR-320a PTPN11 0.801356001806321 4.91397101474502e-09 -0.0515826939037778 0.576869711205509 miRNAWalker2_validate;mirMAP -0.114498649641558 7.23980225732591e-05 NA NA NA hsa-miR-374b-5p PTPN11 -0.288413933608091 0.0041474558664058 -0.0515826939037778 0.576869711205509 mirMAP -0.176786984020678 9.57788085802768e-06 NA NA NA hsa-miR-660-5p PTPN11 -0.202705992887645 0.101093376073573 -0.0515826939037778 0.576869711205509 mirMAP -0.168933026494295 1.73424994830389e-07 NA NA NA hsa-let-7a-5p SOCS1 -0.439381775414001 3.1119785480023e-05 1.85375766969255 6.3472106525335e-25 TargetScan -0.258586667824577 0.000908304706639459 NA NA NA hsa-miR-130b-5p SOCS3 1.77265255049999 1.43627774829684e-29 -0.611154444800435 9.77645620815784e-05 mirMAP -0.204612136346637 6.18220662224556e-07 NA NA NA hsa-miR-339-5p SOCS3 1.07771430326938 2.45772601859307e-09 -0.611154444800435 9.77645620815784e-05 miRanda -0.115158984629657 0.00210200781518323 NA NA NA hsa-miR-629-3p SOCS3 1.43262037314105 2.37092217984413e-19 -0.611154444800435 9.77645620815784e-05 mirMAP -0.138020771845408 0.000918128005401254 NA NA NA hsa-miR-125b-5p SOCS4 -0.993460109818276 5.07736727659894e-12 0.452838124173473 1.23578576891269e-08 miRNATAP -0.115236501186282 1.16637681170584e-06 NA NA NA hsa-miR-140-3p SOCS4 -0.967453553824782 7.6999446305445e-23 0.452838124173473 1.23578576891269e-08 PITA;miRNATAP -0.166094460491692 1.13115238267686e-06 NA NA NA hsa-miR-186-5p SOCS4 0.353452958261612 0.000145058448579496 0.452838124173473 1.23578576891269e-08 mirMAP -0.111370553667105 0.00325456851972988 NA NA NA hsa-miR-34a-5p SOCS4 -0.117372471043915 0.364001947180738 0.452838124173473 1.23578576891269e-08 miRNAWalker2_validate;miRNATAP -0.145277939046613 7.01521026062673e-08 NA NA NA hsa-miR-374b-5p SOCS4 -0.288413933608091 0.0041474558664058 0.452838124173473 1.23578576891269e-08 mirMAP;miRNATAP -0.158926938858194 5.02225047373606e-06 NA NA NA hsa-miR-664a-3p SOCS4 -0.256108763664991 0.0513188660751664 0.452838124173473 1.23578576891269e-08 mirMAP -0.16760859570093 1.93339597166372e-10 NA NA NA hsa-let-7a-3p SOCS5 0.0966652362351867 0.423761916840503 -0.0857348016862387 0.31771480611113 mirMAP -0.17092706452246 2.52305945655746e-08 NA NA NA hsa-miR-141-3p SOCS5 0.730011517758706 0.000120338355004032 -0.0857348016862387 0.31771480611113 TargetScan -0.134180042123119 2.31465160755566e-12 NA NA NA hsa-miR-16-5p SOCS5 0.521122945828175 1.40561786410572e-06 -0.0857348016862387 0.31771480611113 miRNAWalker2_validate -0.134891382971334 8.30362773562974e-05 NA NA NA hsa-miR-21-5p SOCS5 1.62465922021121 3.44191300985109e-58 -0.0857348016862387 0.31771480611113 miRNAWalker2_validate -0.109947636357055 0.000858594981959557 NA NA NA hsa-miR-26b-5p SOCS5 -0.254478038884324 0.0285227763044636 -0.0857348016862387 0.31771480611113 mirMAP -0.191909968428694 1.55718501139276e-09 NA NA NA hsa-miR-342-3p SOCS5 0.99756868977753 9.28499866272332e-10 -0.0857348016862387 0.31771480611113 miRanda -0.19764560583211 9.37038534623228e-20 NA NA NA hsa-miR-374b-5p SOCS5 -0.288413933608091 0.0041474558664058 -0.0857348016862387 0.31771480611113 mirMAP -0.12250987972069 0.000995256482230799 NA NA NA hsa-miR-429 SOCS5 0.559451508722375 0.00563641638673083 -0.0857348016862387 0.31771480611113 miRanda -0.104502017814512 8.7013314434162e-09 NA NA NA hsa-miR-582-5p SOCS5 -0.0366995972742474 0.821827119138923 -0.0857348016862387 0.31771480611113 PITA -0.125741118877723 2.9001498919361e-08 NA NA NA hsa-miR-590-3p SOCS5 0.221436901462551 0.0965904764063157 -0.0857348016862387 0.31771480611113 miRanda;mirMAP -0.130037252259733 3.07013666664193e-06 NA NA NA hsa-miR-590-5p SOCS5 0.763025362395968 3.65305892505623e-09 -0.0857348016862387 0.31771480611113 miRanda -0.174720180825652 4.78131677259519e-10 NA NA NA hsa-miR-7-1-3p SOCS5 1.13646121619622 1.49823237535933e-14 -0.0857348016862387 0.31771480611113 mirMAP -0.168713250584938 2.62611222025637e-12 NA NA NA hsa-miR-17-5p SOCS7 1.41924888736771 2.75805544953758e-18 -0.272560186890545 0.0655062882575215 TargetScan -0.107223597462741 0.00514845439798458 NA NA NA hsa-miR-2355-5p SOCS7 1.47205546931107 8.65192179636668e-19 -0.272560186890545 0.0655062882575215 miRNATAP -0.115786234955086 0.00197639594977944 NA NA NA hsa-miR-320a SOCS7 0.801356001806321 4.91397101474502e-09 -0.272560186890545 0.0655062882575215 PITA;miRanda -0.208393031993087 6.61947436765455e-06 NA NA NA hsa-miR-362-3p SOCS7 -0.697212068252854 2.61718493418184e-06 -0.272560186890545 0.0655062882575215 miRNATAP -0.147610947916579 0.000644331391196301 NA NA NA hsa-miR-590-5p SOCS7 0.763025362395968 3.65305892505623e-09 -0.272560186890545 0.0655062882575215 miRanda -0.135520943912111 0.00598898057238515 NA NA NA hsa-miR-103a-2-5p SOS1 1.37988337975616 6.74852943995612e-08 -0.14430779210223 0.0788675470799712 MirTarget -0.107317494895258 2.70560419461077e-13 NA NA NA hsa-miR-17-5p SOS1 1.41924888736771 2.75805544953758e-18 -0.14430779210223 0.0788675470799712 MirTarget;TargetScan;miRNATAP -0.117731171602632 1.95189099419506e-08 NA NA NA hsa-miR-181a-5p SOS1 0.819060835827404 1.38616688310277e-13 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.100672350932981 0.00144883651704136 NA NA NA hsa-miR-181b-5p SOS1 0.974255518824355 2.64876280203475e-16 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.148558703111288 2.95988138178714e-07 NA NA NA hsa-miR-186-5p SOS1 0.353452958261612 0.000145058448579496 -0.14430779210223 0.0788675470799712 MirTarget;mirMAP -0.152552364062524 7.16812353278593e-05 NA NA NA hsa-miR-20a-5p SOS1 1.1531986665452 1.02385132917958e-11 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.12022910939126 3.57951889599424e-09 NA NA NA hsa-miR-22-5p SOS1 0.706731861922839 3.44318705980007e-07 -0.14430779210223 0.0788675470799712 miRNATAP -0.158730685582191 2.71506892378126e-10 NA NA NA hsa-miR-30b-5p SOS1 -0.400238605368173 0.00346540992719245 -0.14430779210223 0.0788675470799712 mirMAP -0.126352161603185 1.03698542764349e-06 NA NA NA hsa-miR-30c-5p SOS1 0.021222006155897 0.886366656528128 -0.14430779210223 0.0788675470799712 mirMAP;miRNATAP -0.135903886215057 1.16781024741833e-08 NA NA NA hsa-miR-339-5p SOS1 1.07771430326938 2.45772601859307e-09 -0.14430779210223 0.0788675470799712 miRNATAP -0.128892301297403 1.48838832376727e-11 NA NA NA hsa-miR-365a-3p SOS1 0.446833934952926 0.00233857759218299 -0.14430779210223 0.0788675470799712 miRNATAP -0.1783566963117 5.57885493367077e-14 NA NA NA hsa-miR-576-5p SOS1 0.940432050128373 6.90227595663302e-12 -0.14430779210223 0.0788675470799712 mirMAP -0.137121069751198 5.95871216796928e-08 NA NA NA hsa-miR-590-5p SOS1 0.763025362395968 3.65305892505623e-09 -0.14430779210223 0.0788675470799712 miRanda -0.102087263279598 0.000173697009124336 NA NA NA hsa-miR-130a-3p SOS2 0.67051191119964 4.89747518735144e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.142452400506012 9.1977279101434e-07 NA NA NA hsa-miR-130b-3p SOS2 1.44628430084411 9.13980959861273e-24 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.166141799618233 4.74896683998837e-09 NA NA NA hsa-miR-140-5p SOS2 -0.412389003031485 0.000136051708543369 -0.413855174319239 2.70724213132607e-05 miRanda -0.115984900471818 0.00375469960502604 NA NA NA hsa-miR-146b-5p SOS2 0.917975986853978 3.33749259316025e-09 -0.413855174319239 2.70724213132607e-05 miRanda -0.148988622111336 4.132997452968e-08 NA NA NA hsa-miR-15a-5p SOS2 0.783550182002274 2.60699595655907e-11 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.246192745452679 4.355188886614e-12 NA NA NA hsa-miR-15b-5p SOS2 0.85315666454713 3.79816274836297e-12 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.183474265512814 8.3295370014568e-08 NA NA NA hsa-miR-16-5p SOS2 0.521122945828175 1.40561786410572e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.154096465704255 0.000106046501996405 NA NA NA hsa-miR-21-5p SOS2 1.62465922021121 3.44191300985109e-58 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.19831212276022 1.74180372845288e-07 NA NA NA hsa-miR-301a-3p SOS2 2.14132004241926 4.46255413526808e-25 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.120432560927103 7.67307961625067e-10 NA NA NA hsa-miR-320a SOS2 0.801356001806321 4.91397101474502e-09 -0.413855174319239 2.70724213132607e-05 miRanda;miRNATAP -0.180058190704833 4.89057631979479e-09 NA NA NA hsa-miR-454-3p SOS2 1.54137391927201 4.15861570449376e-20 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.189860305441434 3.92270128753751e-15 NA NA NA hsa-miR-590-3p SOS2 0.221436901462551 0.0965904764063157 -0.413855174319239 2.70724213132607e-05 miRanda;mirMAP -0.11728383435213 0.000301105591653965 NA NA NA hsa-miR-590-5p SOS2 0.763025362395968 3.65305892505623e-09 -0.413855174319239 2.70724213132607e-05 PITA;miRanda;miRNATAP -0.141487335002342 1.65802166639907e-05 NA NA NA hsa-let-7a-3p SPRED1 0.0966652362351867 0.423761916840503 -0.0942580706075073 0.389576683861839 miRNATAP -0.172031767997094 1.29530790374541e-05 NA NA NA hsa-miR-130a-3p SPRED1 0.67051191119964 4.89747518735144e-06 -0.0942580706075073 0.389576683861839 miRNATAP -0.126692290671195 8.05861624030441e-05 NA NA NA hsa-miR-141-3p SPRED1 0.730011517758706 0.000120338355004032 -0.0942580706075073 0.389576683861839 miRNATAP -0.176086868552031 5.65143152106351e-13 NA NA NA hsa-miR-15a-5p SPRED1 0.783550182002274 2.60699595655907e-11 -0.0942580706075073 0.389576683861839 miRNATAP -0.234526016133139 2.72507424834115e-09 NA NA NA hsa-miR-15b-5p SPRED1 0.85315666454713 3.79816274836297e-12 -0.0942580706075073 0.389576683861839 miRNATAP -0.144611533703973 0.00014158365044832 NA NA NA hsa-miR-16-1-3p SPRED1 0.955017760172879 5.95379292601146e-11 -0.0942580706075073 0.389576683861839 mirMAP -0.119553912664453 0.000193403076378311 NA NA NA hsa-miR-16-5p SPRED1 0.521122945828175 1.40561786410572e-06 -0.0942580706075073 0.389576683861839 miRNAWalker2_validate;miRNATAP -0.130602234747985 0.00297135110535804 NA NA NA hsa-miR-17-5p SPRED1 1.41924888736771 2.75805544953758e-18 -0.0942580706075073 0.389576683861839 TargetScan;miRNATAP -0.168658965107806 1.53832049180152e-09 NA NA NA hsa-miR-188-5p SPRED1 0.559328953885106 0.000430338888594543 -0.0942580706075073 0.389576683861839 PITA;miRNATAP -0.105786038871965 0.000411309922124914 NA NA NA hsa-miR-200a-3p SPRED1 0.607140814457753 0.00289840524858752 -0.0942580706075073 0.389576683861839 miRNATAP -0.164119284306396 6.14101140163137e-13 NA NA NA hsa-miR-200b-3p SPRED1 0.0717138787925347 0.682858087587209 -0.0942580706075073 0.389576683861839 TargetScan -0.164448093752682 8.46180794788892e-10 NA NA NA hsa-miR-200c-3p SPRED1 0.630251054099546 0.000131975031451555 -0.0942580706075073 0.389576683861839 miRNATAP -0.109872712986963 0.000126514126918787 NA NA NA hsa-miR-20a-5p SPRED1 1.1531986665452 1.02385132917958e-11 -0.0942580706075073 0.389576683861839 miRNATAP -0.176889115472525 6.64616527385488e-11 NA NA NA hsa-miR-224-5p SPRED1 1.94534596857416 1.88348779207332e-19 -0.0942580706075073 0.389576683861839 mirMAP -0.114849289109271 4.81970649653539e-08 NA NA NA hsa-miR-25-3p SPRED1 0.76549796417801 3.32282098247097e-11 -0.0942580706075073 0.389576683861839 mirMAP -0.14747089853886 0.000280508627642679 NA NA NA hsa-miR-26b-5p SPRED1 -0.254478038884324 0.0285227763044636 -0.0942580706075073 0.389576683861839 miRNATAP -0.185799673514904 5.67840034154823e-06 NA NA NA hsa-miR-301a-3p SPRED1 2.14132004241926 4.46255413526808e-25 -0.0942580706075073 0.389576683861839 miRNATAP -0.105041225138789 1.34782550647534e-06 NA NA NA hsa-miR-32-5p SPRED1 -0.317310201890053 0.0102525324475293 -0.0942580706075073 0.389576683861839 mirMAP -0.107087859082616 0.00559592720120723 NA NA NA hsa-miR-34a-5p SPRED1 -0.117372471043915 0.364001947180738 -0.0942580706075073 0.389576683861839 miRNATAP -0.120243968193034 0.00114525481814554 NA NA NA hsa-miR-374b-5p SPRED1 -0.288413933608091 0.0041474558664058 -0.0942580706075073 0.389576683861839 mirMAP -0.164171992205824 0.000556453578744268 NA NA NA hsa-miR-429 SPRED1 0.559451508722375 0.00563641638673083 -0.0942580706075073 0.389576683861839 miRNATAP -0.161559966510552 2.36823151124042e-12 NA NA NA hsa-miR-454-3p SPRED1 1.54137391927201 4.15861570449376e-20 -0.0942580706075073 0.389576683861839 miRNATAP -0.145710466104983 7.24709383908652e-08 NA NA NA hsa-miR-500a-5p SPRED1 0.675401699376111 8.24389004707854e-05 -0.0942580706075073 0.389576683861839 mirMAP -0.128999756700585 2.56473679665994e-06 NA NA NA hsa-miR-664a-3p SPRED1 -0.256108763664991 0.0513188660751664 -0.0942580706075073 0.389576683861839 mirMAP -0.148923721572358 3.90174691498162e-05 NA NA NA hsa-miR-92a-3p SPRED1 0.994679542307232 1.32587679156217e-16 -0.0942580706075073 0.389576683861839 mirMAP -0.201535357901948 1.34564778698966e-07 NA NA NA hsa-miR-93-3p SPRED1 1.69225547123293 1.50964095575087e-25 -0.0942580706075073 0.389576683861839 miRNATAP -0.115771635495181 3.28931745948963e-05 NA NA NA hsa-miR-93-5p SPRED1 1.61042951896619 5.1280369606967e-24 -0.0942580706075073 0.389576683861839 miRNAWalker2_validate;miRNATAP -0.147207380762588 1.98943303858325e-07 NA NA NA hsa-miR-146b-5p SPRED2 0.917975986853978 3.33749259316025e-09 -0.0574582856769892 0.646339377147345 miRanda -0.154338608068589 7.27178563405262e-06 NA NA NA hsa-miR-17-5p SPRED2 1.41924888736771 2.75805544953758e-18 -0.0574582856769892 0.646339377147345 mirMAP -0.111058507234638 0.000585924500044478 NA NA NA hsa-miR-186-5p SPRED2 0.353452958261612 0.000145058448579496 -0.0574582856769892 0.646339377147345 miRNAWalker2_validate -0.227052101785278 0.00010892301763164 NA NA NA hsa-miR-20a-5p SPRED2 1.1531986665452 1.02385132917958e-11 -0.0574582856769892 0.646339377147345 mirMAP -0.145315194498095 3.41814206760216e-06 NA NA NA hsa-miR-338-3p SPRED2 -0.948755228846395 8.99167125682392e-08 -0.0574582856769892 0.646339377147345 miRanda -0.16707648281744 2.53723013952619e-08 NA NA NA hsa-miR-339-5p SPRED2 1.07771430326938 2.45772601859307e-09 -0.0574582856769892 0.646339377147345 miRanda -0.159781037510716 5.3495928348844e-08 NA NA NA hsa-miR-362-5p SPRED2 0.41089772861323 0.0404254902071382 -0.0574582856769892 0.646339377147345 PITA -0.173886210547267 7.24405852985525e-11 NA NA NA hsa-miR-500a-5p SPRED2 0.675401699376111 8.24389004707854e-05 -0.0574582856769892 0.646339377147345 mirMAP -0.166805095946625 9.57365752466398e-08 NA NA NA hsa-miR-590-5p SPRED2 0.763025362395968 3.65305892505623e-09 -0.0574582856769892 0.646339377147345 miRanda -0.133568642293675 0.00131779128643207 NA NA NA hsa-miR-93-5p SPRED2 1.61042951896619 5.1280369606967e-24 -0.0574582856769892 0.646339377147345 mirMAP -0.108814894528012 0.000848107144671818 NA NA NA hsa-let-7a-3p SPRY1 0.0966652362351867 0.423761916840503 -1.27831449380241 6.49126312066769e-19 miRNATAP -0.247687361721908 4.08990422408686e-06 NA NA NA hsa-miR-16-2-3p SPRY1 1.1567130855258 1.01867256952189e-14 -1.27831449380241 6.49126312066769e-19 mirMAP -0.406041464782539 1.47515624465774e-23 NA NA NA hsa-miR-20a-3p SPRY1 1.34885093664027 2.07697464119202e-12 -1.27831449380241 6.49126312066769e-19 miRNATAP -0.236291711874864 3.1140515464526e-13 NA NA NA hsa-miR-21-5p SPRY1 1.62465922021121 3.44191300985109e-58 -1.27831449380241 6.49126312066769e-19 miRNATAP -0.417756982910329 1.23803177350958e-13 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-29b-3p SPRY1 -0.110721443686039 0.511264554091106 -1.27831449380241 6.49126312066769e-19 miRNATAP -0.147438948750238 0.00012857862426121 NA NA NA hsa-miR-324-3p SPRY1 0.867391246413545 3.63808540490361e-10 -1.27831449380241 6.49126312066769e-19 miRNAWalker2_validate -0.172097212301602 0.00019297521375217 NA NA NA hsa-miR-339-5p SPRY1 1.07771430326938 2.45772601859307e-09 -1.27831449380241 6.49126312066769e-19 miRanda -0.304417436020496 6.15685188825829e-19 NA NA NA hsa-miR-3615 SPRY1 0.761416334979744 9.83072409815373e-09 -1.27831449380241 6.49126312066769e-19 miRNAWalker2_validate -0.230817879490729 1.56692724279239e-06 NA NA NA hsa-miR-421 SPRY1 0.945488088619653 2.35762398527362e-09 -1.27831449380241 6.49126312066769e-19 PITA;miRanda;miRNATAP -0.120600021924699 0.00295011180088054 NA NA NA hsa-miR-450b-5p SPRY1 1.25529820885833 1.18847120528666e-15 -1.27831449380241 6.49126312066769e-19 PITA;miRNATAP -0.173513706396345 1.52051129556701e-05 NA NA NA hsa-miR-455-3p SPRY1 2.68574446868387 4.28975903022818e-42 -1.27831449380241 6.49126312066769e-19 miRNATAP -0.178649793157301 2.10099928054292e-09 NA NA NA hsa-miR-550a-3p SPRY1 1.63595944765448 5.87048146042097e-24 -1.27831449380241 6.49126312066769e-19 miRNATAP -0.25878529935816 1.3286892339143e-11 NA NA NA hsa-miR-590-5p SPRY1 0.763025362395968 3.65305892505623e-09 -1.27831449380241 6.49126312066769e-19 PITA;miRanda;miRNATAP -0.386465204870038 1.36689669151861e-15 NA NA NA hsa-miR-181a-5p SPRY2 0.819060835827404 1.38616688310277e-13 -1.26408245951502 3.41685858396126e-12 miRNAWalker2_validate -0.273789043590521 0.000129466090488552 NA NA NA hsa-miR-21-5p SPRY2 1.62465922021121 3.44191300985109e-58 -1.26408245951502 3.41685858396126e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.409774432500143 7.41221325179375e-09 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-330-5p SPRY2 0.944693925383906 5.04972895657346e-13 -1.26408245951502 3.41685858396126e-12 miRanda;miRNATAP -0.2739672348233 5.51579020924956e-06 NA NA NA hsa-miR-452-5p SPRY2 0.373288744398455 0.0348485937209964 -1.26408245951502 3.41685858396126e-12 miRNATAP -0.241801455943905 9.21270333374218e-08 NA NA NA hsa-miR-455-5p SPRY2 1.408595672323 5.52039116456697e-22 -1.26408245951502 3.41685858396126e-12 miRanda -0.365738950868675 2.30997267918186e-12 NA NA NA hsa-miR-590-5p SPRY2 0.763025362395968 3.65305892505623e-09 -1.26408245951502 3.41685858396126e-12 PITA;miRanda;miRNATAP -0.269299994807865 1.19845805319195e-05 NA NA NA hsa-let-7a-3p SPRY3 0.0966652362351867 0.423761916840503 -0.51598809801432 0.000132196791034093 MirTarget;mirMAP -0.250735066166565 2.77910879805387e-07 NA NA NA hsa-let-7f-1-3p SPRY3 0.700374242293247 8.65000484720084e-08 -0.51598809801432 0.000132196791034093 MirTarget;mirMAP -0.146654105034135 0.00104802734787965 NA NA NA hsa-miR-103a-2-5p SPRY3 1.37988337975616 6.74852943995612e-08 -0.51598809801432 0.000132196791034093 mirMAP -0.127666806687395 2.22151386805277e-07 NA NA NA hsa-miR-130a-3p SPRY3 0.67051191119964 4.89747518735144e-06 -0.51598809801432 0.000132196791034093 mirMAP -0.182704428474898 4.38893113745111e-06 NA NA NA hsa-miR-130b-3p SPRY3 1.44628430084411 9.13980959861273e-24 -0.51598809801432 0.000132196791034093 mirMAP -0.144004765504261 0.000241340489790222 NA NA NA hsa-miR-130b-5p SPRY3 1.77265255049999 1.43627774829684e-29 -0.51598809801432 0.000132196791034093 mirMAP -0.100543944811469 0.00471615898702322 NA NA NA hsa-miR-141-3p SPRY3 0.730011517758706 0.000120338355004032 -0.51598809801432 0.000132196791034093 mirMAP -0.108361946782658 0.000453666225476348 NA NA NA hsa-miR-182-5p SPRY3 1.15060905311096 6.25565852529946e-10 -0.51598809801432 0.000132196791034093 mirMAP -0.111098976506995 0.000366128648811991 NA NA NA hsa-miR-183-5p SPRY3 1.4313129319945 6.25230916431996e-14 -0.51598809801432 0.000132196791034093 MirTarget -0.100397061206781 0.00087566221731612 NA NA NA hsa-miR-205-3p SPRY3 1.2960640797621 5.80786479909147e-11 -0.51598809801432 0.000132196791034093 mirMAP -0.122741444959912 2.5714454105751e-05 NA NA NA hsa-miR-21-3p SPRY3 1.25126438776674 2.4124216716282e-17 -0.51598809801432 0.000132196791034093 mirMAP -0.205366537650335 9.26559376841155e-08 NA NA NA hsa-miR-29a-5p SPRY3 0.323252792625584 0.0370417231222825 -0.51598809801432 0.000132196791034093 mirMAP -0.13257064889478 0.000502791854572278 NA NA NA hsa-miR-320a SPRY3 0.801356001806321 4.91397101474502e-09 -0.51598809801432 0.000132196791034093 miRNAWalker2_validate;miRanda;mirMAP -0.125117703285046 0.00334594917200067 NA NA NA hsa-miR-320b SPRY3 1.23473838180754 3.04337566045537e-14 -0.51598809801432 0.000132196791034093 miRanda;mirMAP -0.105962343826989 0.00281249724616315 NA NA NA hsa-miR-339-5p SPRY3 1.07771430326938 2.45772601859307e-09 -0.51598809801432 0.000132196791034093 miRanda -0.136816797838584 1.98587272541176e-05 NA NA NA hsa-miR-455-3p SPRY3 2.68574446868387 4.28975903022818e-42 -0.51598809801432 0.000132196791034093 miRNATAP -0.132549109480292 1.19945620251305e-06 NA NA NA hsa-miR-484 SPRY3 0.918280909791707 1.39168306854263e-14 -0.51598809801432 0.000132196791034093 miRNATAP -0.174853555527109 0.000301787998822328 NA NA NA hsa-miR-576-5p SPRY3 0.940432050128373 6.90227595663302e-12 -0.51598809801432 0.000132196791034093 mirMAP -0.164066284693373 0.000101853691978422 NA NA NA hsa-miR-708-3p SPRY3 1.32647174389322 4.87465491977979e-16 -0.51598809801432 0.000132196791034093 MirTarget;mirMAP -0.15979099881512 4.77263509157722e-06 NA NA NA hsa-miR-708-5p SPRY3 1.54207894190626 2.2887257992285e-19 -0.51598809801432 0.000132196791034093 MirTarget -0.14665828030081 9.34246762884549e-06 NA NA NA hsa-miR-96-5p SPRY3 1.42326703011157 4.39736150032373e-14 -0.51598809801432 0.000132196791034093 MirTarget;TargetScan -0.150141355357773 7.37561992387412e-07 NA NA NA hsa-miR-140-3p SPRY4 -0.967453553824782 7.6999446305445e-23 1.65093100608809 3.59794139825157e-25 PITA;miRNATAP -0.405849226044493 9.56039621700656e-09 NA NA NA hsa-miR-140-5p SPRY4 -0.412389003031485 0.000136051708543369 1.65093100608809 3.59794139825157e-25 PITA;miRanda;miRNATAP -0.245484625424409 0.000269963164577679 NA NA NA hsa-miR-141-3p SPRY4 0.730011517758706 0.000120338355004032 1.65093100608809 3.59794139825157e-25 TargetScan;miRNATAP -0.10318939364404 0.00689742430015885 NA NA NA hsa-miR-148a-5p SPRY4 -1.00478606532747 1.38045244999229e-07 1.65093100608809 3.59794139825157e-25 mirMAP -0.133790708411739 0.000384626032445054 NA NA NA hsa-miR-181c-5p SPRY4 -0.168991199007857 0.196949106150297 1.65093100608809 3.59794139825157e-25 miRNATAP -0.197145085245669 0.000409717145062003 NA NA NA hsa-miR-195-3p SPRY4 -0.624259620429699 0.000164279659144497 1.65093100608809 3.59794139825157e-25 mirMAP -0.219063764483499 5.31169839589748e-07 NA NA NA hsa-miR-195-5p SPRY4 -1.8367376818177 6.9944883988895e-31 1.65093100608809 3.59794139825157e-25 miRNATAP -0.244109915448894 1.08222847501473e-08 NA NA NA hsa-miR-200a-3p SPRY4 0.607140814457753 0.00289840524858752 1.65093100608809 3.59794139825157e-25 mirMAP;miRNATAP -0.149406202708277 2.53396875052402e-05 NA NA NA hsa-miR-20b-5p SPRY4 0.345967670847176 0.232014828043601 1.65093100608809 3.59794139825157e-25 miRNATAP -0.108533993745347 1.46715927898215e-05 NA NA NA hsa-miR-26b-5p SPRY4 -0.254478038884324 0.0285227763044636 1.65093100608809 3.59794139825157e-25 mirMAP -0.259010898356838 3.6960777761905e-05 NA NA NA hsa-miR-29a-3p SPRY4 -1.26881270980079 2.82496991513463e-22 1.65093100608809 3.59794139825157e-25 miRNATAP -0.282982919961966 9.85584184624913e-08 NA NA NA hsa-miR-29b-3p SPRY4 -0.110721443686039 0.511264554091106 1.65093100608809 3.59794139825157e-25 miRNATAP -0.204113293785212 2.11037979082892e-06 NA NA NA hsa-miR-29c-3p SPRY4 -2.08166260448948 8.3238369390898e-24 1.65093100608809 3.59794139825157e-25 miRNATAP -0.281167069477891 6.12157398344807e-18 NA NA NA hsa-miR-30b-3p SPRY4 -0.338530747940815 0.0223424741180399 1.65093100608809 3.59794139825157e-25 miRNATAP -0.223038182268002 5.44651234722086e-06 NA NA NA hsa-miR-335-5p SPRY4 -1.17227779671552 1.49282618530733e-10 1.65093100608809 3.59794139825157e-25 miRNAWalker2_validate -0.168142229306612 1.56810506092727e-05 NA NA NA hsa-miR-340-5p SPRY4 -0.608415693437977 4.44345153563513e-05 1.65093100608809 3.59794139825157e-25 mirMAP -0.127017811591088 0.0091523198925287 NA NA NA hsa-miR-361-3p SPRY4 0.272298288982435 0.0147874880476998 1.65093100608809 3.59794139825157e-25 miRNATAP -0.172412006514188 0.00861794044200005 NA NA NA hsa-miR-429 SPRY4 0.559451508722375 0.00563641638673083 1.65093100608809 3.59794139825157e-25 miRanda -0.138957773735111 0.000106181930542424 NA NA NA hsa-miR-497-5p SPRY4 -0.966244470847844 5.26505649147857e-12 1.65093100608809 3.59794139825157e-25 miRNATAP -0.299343250330047 2.94318061626033e-09 NA NA NA hsa-miR-25-3p STAM 0.76549796417801 3.32282098247097e-11 -0.124415418068954 0.180429346977726 MirTarget -0.196036597226663 8.80670687024712e-09 NA NA NA hsa-miR-32-5p STAM -0.317310201890053 0.0102525324475293 -0.124415418068954 0.180429346977726 MirTarget -0.106758496661323 0.00109945203151921 NA NA NA hsa-miR-335-3p STAM 0.336785882180547 0.0542446207938138 -0.124415418068954 0.180429346977726 MirTarget -0.106564724765154 3.3345681673728e-06 NA NA NA hsa-miR-664a-3p STAM -0.256108763664991 0.0513188660751664 -0.124415418068954 0.180429346977726 MirTarget -0.109499545311225 0.000368862330615119 NA NA NA hsa-miR-146b-5p STAM2 0.917975986853978 3.33749259316025e-09 -0.457824809884554 3.1481595076542e-09 miRanda -0.109621602257612 3.28505031536177e-07 NA NA NA hsa-miR-186-5p STAM2 0.353452958261612 0.000145058448579496 -0.457824809884554 3.1481595076542e-09 mirMAP -0.179403756130515 9.19375509071855e-07 NA NA NA hsa-miR-20a-3p STAM2 1.34885093664027 2.07697464119202e-12 -0.457824809884554 3.1481595076542e-09 MirTarget -0.105796740519275 6.38885641063782e-10 NA NA NA hsa-miR-25-3p STAM2 0.76549796417801 3.32282098247097e-11 -0.457824809884554 3.1481595076542e-09 mirMAP -0.147063675094619 3.49494988285684e-07 NA NA NA hsa-miR-320a STAM2 0.801356001806321 4.91397101474502e-09 -0.457824809884554 3.1481595076542e-09 miRanda -0.133419573068879 4.13335727110661e-08 NA NA NA hsa-miR-505-5p STAM2 1.25888458076414 7.80089782306577e-13 -0.457824809884554 3.1481595076542e-09 MirTarget -0.136344092647453 1.98289411931602e-13 NA NA NA hsa-miR-664a-3p STAM2 -0.256108763664991 0.0513188660751664 -0.457824809884554 3.1481595076542e-09 mirMAP -0.12469200344782 1.37466154738021e-06 NA NA NA hsa-miR-92a-3p STAM2 0.994679542307232 1.32587679156217e-16 -0.457824809884554 3.1481595076542e-09 mirMAP -0.138854319554671 3.92086364559058e-07 NA NA NA hsa-miR-129-5p STAT1 -0.246329588499478 0.436451191224681 1.29636069409508 5.42773871497242e-12 miRanda -0.14188918551735 9.31107592405221e-08 NA NA NA hsa-miR-145-5p STAT1 -0.46917511594055 0.000685297625493134 1.29636069409508 5.42773871497242e-12 miRNAWalker2_validate;miRTarBase -0.321524015834427 8.06935548764194e-08 20098684 MicroRNA 145 targets YES and STAT1 in colon cancer cells; Both YES and STAT1 were verified as direct miR-145 targets colon cancer hsa-miR-182-5p STAT1 1.15060905311096 6.25565852529946e-10 1.29636069409508 5.42773871497242e-12 mirMAP -0.166989770502861 0.0001533740924006 NA NA NA hsa-miR-30c-2-3p STAT1 -1.82791447399693 2.41509888037865e-21 1.29636069409508 5.42773871497242e-12 MirTarget -0.242627150244141 3.76250606864777e-09 NA NA NA hsa-miR-361-5p STAT1 0.0803683277369505 0.314043140368058 1.29636069409508 5.42773871497242e-12 miRanda -0.680793306412556 9.07684658637059e-11 NA NA NA hsa-miR-495-3p STAT1 -1.47803501311999 6.88839745293927e-13 1.29636069409508 5.42773871497242e-12 MirTarget -0.145636474966693 0.000247776211956383 NA NA NA hsa-miR-96-5p STAT1 1.42326703011157 4.39736150032373e-14 1.29636069409508 5.42773871497242e-12 mirMAP -0.176220949258146 4.33457106430883e-05 NA NA NA hsa-let-7c-5p STAT2 -2.07953368242668 3.46048888391218e-23 0.965822398486433 2.53209127914211e-15 MirTarget -0.143386923264525 5.66166946706566e-09 NA NA NA hsa-miR-24-3p STAT2 0.13115428390042 0.203891651275156 0.965822398486433 2.53209127914211e-15 MirTarget -0.152790721376542 0.00425021598263232 NA NA NA hsa-miR-335-5p STAT2 -1.17227779671552 1.49282618530733e-10 0.965822398486433 2.53209127914211e-15 miRNAWalker2_validate -0.191321042724947 3.31045279917287e-11 NA NA NA hsa-miR-98-5p STAT2 0.0176698653376732 0.858271091070735 0.965822398486433 2.53209127914211e-15 MirTarget -0.177320985532968 0.00148562144768156 NA NA NA hsa-miR-125a-5p STAT3 0.215366061934933 0.119550904549401 -0.220244482215513 0.0102868167365082 PITA;miRanda -0.160299203376007 2.02047194416412e-09 26389681;26878391 MiR 125a suppresses tumor growth invasion and metastasis in cervical cancer by targeting STAT3; Dual luciferase assays identified the STAT3 gene as a novel direct target of miR-125a; Functional studies showed that miR-125a overexpression significantly suppressed the growth invasion and epithelial-mesenchymal transition EMT of cervical cancer cells both in vitro and in vivo via decreasing STAT3 expression; Clinically STAT3 the expression of which predicted poorer outcome was inversely correlated with miR-125a in cervical cancer;MiR 125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression; Moreover we determined that miR-125a increased paclitaxel and cisplatin sensitivity by downregulating STAT3 metastasis; cervical and endocervical cancer;cervical and endocervical cancer hsa-miR-17-5p STAT3 1.41924888736771 2.75805544953758e-18 -0.220244482215513 0.0102868167365082 TargetScan;miRNATAP -0.121533033377623 3.14630839392627e-08 NA NA NA hsa-miR-20a-5p STAT3 1.1531986665452 1.02385132917958e-11 -0.220244482215513 0.0102868167365082 miRNAWalker2_validate;miRNATAP -0.121761349797683 1.18930883073153e-08 NA NA NA hsa-miR-21-5p STAT3 1.62465922021121 3.44191300985109e-58 -0.220244482215513 0.0102868167365082 miRNAWalker2_validate;miRNATAP -0.102782294315177 0.00190579669708757 26690371;20113523;25994220;21940630;22547075;22709411;25087183;26212010;25720799;26549725 Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors; This finding suggests that CDK5 may be an important cofactor for targeting when designing metastasis-blocking therapy by targeting STAT3/miR-21 axis with STAT3 inhibitor or miR-21 antisense oligonucleotide;Meanwhile the expression of STAT3 and p-STAT3 decreased to relatively low levels after miR-21 inhibitor and taxol treatment; The data strongly suggested that a regulatory loop between miR-21 and STAT3 might provide an insight into the mechanism of modulating EGFR/STAT3 signaling; A combination of miR-21 inhibitor and taxol could be an effective therapeutic strategy for controlling the growth of GBM by inhibiting STAT3 expression and phosphorylation;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;We found that miR-21 is a member of an IFN-induced miRNA subset that requires STAT3 activation;NF-κB-dependent IL-6 up-regulation is responsible for STAT3 activation and recruitment to the miR-21 promoter upon genotoxic stress;MiR 21 modulates hTERT through a STAT3 dependent manner on glioblastoma cell growth; Finally knockdown of miR-21 considerably inhibited tumor growth and diminished the expression of STAT3 and hTERT in xenograft model; Our findings indicate that miR-21 regulates hTERT expression mediated by STAT3 therefore controlling GBM cell growth;Subsequently we showed that the upregulation of miR-21 was mediated by HBx-induced interleukin-6 pathway followed by activation of STAT3 transcriptional factor;Moreover we showed that Stat3 co-opts NErbB-2 function by recruiting ErbB-2 as its coactivator at the GAS sites in the promoter of microRNA-21 miR-21 a metastasis-promoting microRNA miRNA; Using an ErbB-2 nuclear localization domain mutant and a constitutively activated ErbB-2 variant we found that NErbB-2 role as a Stat3 coactivator and also its direct role as transcription factor upregulate miR-21 in BC; Using an in vivo model of metastatic ErbB-2-postive BC in which we silenced Stat3 and reconstituted ErbB-2 or miR-21 expression we showed that both are downstream mediators of Stat3-driven metastasis;Invasion and migration of HCC cells in vitro were inhibited by both STAT3 and miR-21 antagonists suggesting a role for this pathway in HCC tumor progression;Finally western blotting was performed to determine if miR-21 regulated expression of signal transducers and activators of transcription 3 STAT3 and assays of cell proliferation colony formation migration and invasion were performed to examine the role of STAT3 in regulation of breast cancer cells; In addition we identified a putative miR-21 binding site in the 3'-untranslated region of the STAT3 gene using an online bioinformatical tool; We found that protein expression of STAT3 was significantly downregulated when breast cancer cells were transfected with miR-21 mimics and was significantly upregulated in breast cancer cells transfected with a miR-21 inhibitor; Our data suggest that miR-21 expression is increased in breast cancer and plays an important role as a tumor gene by targeting STAT3 which may act as a double-response controller in breast cancer progression;metastasis;;;;;;;metastasis;progression;drug resistance head and neck cancer;glioblastoma;colorectal cancer;melanoma;breast cancer;glioblastoma;liver cancer;breast cancer;liver cancer;breast cancer hsa-miR-590-5p STAT3 0.763025362395968 3.65305892505623e-09 -0.220244482215513 0.0102868167365082 miRanda;miRNATAP -0.119823530586293 2.49815456349259e-05 27757042 We found that the AKT/ERK and STAT3 signaling pathways were activated by miR-590-5p overexpression gastric cancer hsa-miR-92a-3p STAT3 0.994679542307232 1.32587679156217e-16 -0.220244482215513 0.0102868167365082 miRNAWalker2_validate -0.113928295190106 0.000159932425220867 23820254 STAT3 upregulates miR 92a to inhibit RECK expression and to promote invasiveness of lung cancer cells; We demonstrate that STAT3 upregulates miR-92a to repress RECK via post-transcriptional inhibition lung cancer hsa-miR-93-5p STAT3 1.61042951896619 5.1280369606967e-24 -0.220244482215513 0.0102868167365082 miRNAWalker2_validate;miRNATAP -0.119135219329325 7.88988014801665e-08 NA NA NA hsa-miR-141-3p STAT4 0.730011517758706 0.000120338355004032 0.989595568248864 1.444349763024e-07 MirTarget;TargetScan -0.152569503314241 0.000435014370559497 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 0.607140814457753 0.00289840524858752 0.989595568248864 1.444349763024e-07 MirTarget -0.148750823690028 0.000236516607970599 NA NA NA hsa-miR-141-3p STAT5A 0.730011517758706 0.000120338355004032 0.0195863360284196 0.880478009147168 MirTarget;TargetScan;miRNATAP -0.120372831492165 4.6208422861356e-05 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-452-5p STAT5A 0.373288744398455 0.0348485937209964 0.0195863360284196 0.880478009147168 MirTarget;miRNATAP -0.14728109786687 3.64771870024993e-06 NA NA NA hsa-miR-141-3p STAT5B 0.730011517758706 0.000120338355004032 -0.30367777891697 0.000811728898734079 MirTarget;TargetScan;miRNATAP -0.17845757011256 5.33484602791183e-19 NA NA NA hsa-miR-200a-3p STAT5B 0.607140814457753 0.00289840524858752 -0.30367777891697 0.000811728898734079 MirTarget;miRNATAP -0.147137204288654 6.29357083080121e-15 NA NA NA hsa-miR-20a-3p STAT5B 1.34885093664027 2.07697464119202e-12 -0.30367777891697 0.000811728898734079 miRNATAP -0.106490449719728 9.76764866970301e-08 NA NA NA hsa-miR-21-3p STAT5B 1.25126438776674 2.4124216716282e-17 -0.30367777891697 0.000811728898734079 MirTarget -0.10855468526989 2.72312106964419e-05 NA NA NA hsa-miR-23a-3p STAT5B 0.348231698801568 6.4911858506572e-05 -0.30367777891697 0.000811728898734079 MirTarget;miRNATAP -0.184694071088515 4.98124128791717e-05 NA NA NA hsa-miR-93-3p STAT5B 1.69225547123293 1.50964095575087e-25 -0.30367777891697 0.000811728898734079 miRNAWalker2_validate -0.124761566470815 6.09154527014791e-08 NA NA NA hsa-miR-361-5p STAT6 0.0803683277369505 0.314043140368058 -0.0905121999078942 0.262892244873058 miRanda -0.155183193845645 0.000509120957164828 NA NA NA hsa-miR-19a-3p TPO 1.35800152353624 2.80940447111944e-12 -1.52724712553739 1.77750754514838e-06 mirMAP -0.296881572606174 2.54871792663227e-05 NA NA NA hsa-miR-19b-3p TPO 0.538732279378089 0.000622008277870679 -1.52724712553739 1.77750754514838e-06 mirMAP -0.252080591249665 0.00469333215311015 NA NA NA hsa-miR-205-3p TPO 1.2960640797621 5.80786479909147e-11 -1.52724712553739 1.77750754514838e-06 mirMAP -0.501233959855944 2.07045832439491e-13 NA NA NA hsa-miR-29a-5p TPO 0.323252792625584 0.0370417231222825 -1.52724712553739 1.77750754514838e-06 mirMAP -0.27026349271909 0.00293115487445507 NA NA NA hsa-miR-450b-5p TPO 1.25529820885833 1.18847120528666e-15 -1.52724712553739 1.77750754514838e-06 mirMAP -0.269312765755246 0.00202874700557811 NA NA NA hsa-miR-92a-3p TPO 0.994679542307232 1.32587679156217e-16 -1.52724712553739 1.77750754514838e-06 mirMAP -0.365792450337945 0.00132169162210287 NA NA NA