miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ABI3BP 0.241662461253461 0.0170788899505389 -1.96423060831669 2.74629023353596e-11 miRanda -0.487284627775614 0.000873057851423183 NA NA NA hsa-miR-32-3p ABI3BP 0.219109440121582 0.207217051619543 -1.96423060831669 2.74629023353596e-11 mirMAP -0.440412536546636 3.98106274079596e-07 NA NA NA hsa-miR-32-5p ABI3BP 0.0806126674664016 0.548984992497432 -1.96423060831669 2.74629023353596e-11 miRNATAP -0.614031051070129 1.5780284506138e-08 NA NA NA hsa-miR-374a-5p ABI3BP 0.016390363747302 0.869784217438621 -1.96423060831669 2.74629023353596e-11 mirMAP -0.42461382816527 0.00442723092496611 NA NA NA hsa-miR-421 ABI3BP 0.941856334694081 6.12167297054077e-08 -1.96423060831669 2.74629023353596e-11 miRanda -0.254753311937686 0.00235744265300136 NA NA NA hsa-miR-590-5p ABI3BP -0.103355559980404 0.310027295317092 -1.96423060831669 2.74629023353596e-11 miRanda -0.498807353571986 0.000636586180101588 NA NA NA hsa-miR-92a-3p ABI3BP 0.212391012518195 0.134292268089997 -1.96423060831669 2.74629023353596e-11 miRNATAP -0.291450970904234 0.00520307205627749 NA NA NA hsa-miR-139-5p ADAM12 -2.11299531796557 8.16407076415038e-28 0.932873928230232 0.0022018820638591 miRanda -0.370096155057971 2.0870545371508e-07 NA NA NA hsa-miR-204-5p ADAM12 -0.537962150012103 0.0330895493358849 0.932873928230232 0.0022018820638591 mirMAP -0.385731609614865 2.40241902315869e-11 NA NA NA hsa-miR-26b-5p ADAM12 -1.10804856399744 4.14176110314282e-22 0.932873928230232 0.0022018820638591 mirMAP;miRNATAP -0.533099809389338 1.5583170197884e-05 NA NA NA hsa-miR-33a-3p ADAM12 -0.683025859637737 1.01106097756419e-05 0.932873928230232 0.0022018820638591 mirMAP -0.398426695406119 2.8772956463106e-05 NA NA NA hsa-miR-3607-3p ADAM12 -2.15518588554493 1.03390728226728e-23 0.932873928230232 0.0022018820638591 mirMAP;miRNATAP -0.271596146194876 3.11070950125972e-05 NA NA NA hsa-miR-374a-5p ADAM12 0.016390363747302 0.869784217438621 0.932873928230232 0.0022018820638591 mirMAP -0.475287436845527 0.00162471829716735 NA NA NA hsa-miR-374b-5p ADAM12 -0.307538028546424 0.0030079617545972 0.932873928230232 0.0022018820638591 mirMAP -0.566453360566601 8.44073011982717e-05 NA NA NA hsa-miR-155-5p ANPEP 0.0108524225071784 0.95651331033505 -0.914605441330613 4.19025373805737e-07 miRNAWalker2_validate -0.15568303502288 0.000513325060834501 NA NA NA hsa-miR-423-5p ANPEP 0.698807775906485 1.02195196334612e-11 -0.914605441330613 4.19025373805737e-07 miRNATAP -0.258668352577126 0.00246029599154661 NA NA NA hsa-miR-107 AREG 0.241662461253461 0.0170788899505389 -1.66916755239492 3.18915674348661e-06 miRanda -1.19885254866637 2.85025233054889e-12 NA NA NA hsa-miR-107 BASP1 0.241662461253461 0.0170788899505389 -1.79834075438828 4.93205126933049e-12 miRanda -0.729163866238412 1.16557278105477e-08 NA NA NA hsa-miR-193b-3p BASP1 -0.166697207281748 0.272022543069482 -1.79834075438828 4.93205126933049e-12 miRNAWalker2_validate -0.29666556579452 0.000559594793830276 NA NA NA hsa-miR-33a-3p BASP1 -0.683025859637737 1.01106097756419e-05 -1.79834075438828 4.93205126933049e-12 miRNATAP -0.345564012314798 3.31067345541251e-05 NA NA NA hsa-miR-361-5p BASP1 0.233202959858696 0.00961572812255327 -1.79834075438828 4.93205126933049e-12 miRanda -0.850934553499141 3.46868339805737e-09 NA NA NA hsa-miR-532-3p BASP1 0.297601533259956 0.014632205884815 -1.79834075438828 4.93205126933049e-12 PITA -0.58139087592439 4.05966867005538e-08 NA NA NA hsa-miR-107 BDNF 0.241662461253461 0.0170788899505389 0.0509404608382562 0.831886089502745 MirTarget;PITA;miRanda;miRNATAP -0.548625326436466 1.91129941815694e-06 27498977 MicroRNA 107 inhibits tumor growth and metastasis by targeting the BDNF mediated PI3K/AKT pathway in human non small lung cancer; In addition BDNF expression was upregulated and inversely correlated with miR-107 in NSCLC tissues; Enforced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-107 on NSCLC proliferation migration and invasion; miR-107 overexpression or downregulation of BDNF was able to inhibit activation of PI3K/AKT signaling pathway; Taken together our findings present the first evidence that miR-107 could suppress NSCLC metastasis by targeting BDNF and indirectly regulating PI3K/AKT signaling pathway which might lead to a potential therapeutic strategy focusing on miR-107 and BDNF for human NSCLC metastasis lung cancer hsa-miR-148a-5p BDNF -0.767626696027761 1.08359477494797e-06 0.0509404608382562 0.831886089502745 mirMAP -0.25723398567524 0.00044233258998089 NA NA NA hsa-miR-192-3p BDNF -0.6401165114007 0.000266272092403814 0.0509404608382562 0.831886089502745 MirTarget;miRNATAP -0.316265894039516 1.40962674503077e-06 NA NA NA hsa-miR-30d-5p BDNF 0.718283816348023 2.47422074061352e-08 0.0509404608382562 0.831886089502745 miRNATAP -0.295547331188199 0.000945690035537912 NA NA NA hsa-miR-589-5p BDNF 1.18593770505086 1.01781241960531e-22 0.0509404608382562 0.831886089502745 miRNATAP -0.237064825478246 0.0099909566497615 NA NA NA hsa-miR-148b-5p BMP1 0.295777213389605 0.0255749859535438 -0.409493388556717 0.00096398049769483 mirMAP -0.200704126519952 1.11412844282431e-05 NA NA NA hsa-miR-185-5p BMP1 0.480006257154717 6.35758891340152e-07 -0.409493388556717 0.00096398049769483 mirMAP -0.223548038809664 0.000358256409057043 NA NA NA hsa-miR-339-5p BMP1 0.280589919878422 0.0355660282647215 -0.409493388556717 0.00096398049769483 miRanda -0.149224303312488 0.00104250667939213 NA NA NA hsa-miR-484 BMP1 0.0857240033709656 0.453982056282229 -0.409493388556717 0.00096398049769483 miRNATAP -0.210864232508227 7.35102276593662e-05 NA NA NA hsa-miR-92a-1-5p BMP1 0.389443191151075 0.0644925359204601 -0.409493388556717 0.00096398049769483 mirMAP -0.196559484879421 2.96257781132342e-12 NA NA NA hsa-miR-10a-5p CADM1 -1.47723516092033 7.27299669108673e-16 -0.0259171422650883 0.886286112596045 MirTarget;miRNATAP -0.131834650151903 0.00451300378314575 NA NA NA hsa-miR-141-3p CADM1 -0.354316381352484 0.256996894288799 -0.0259171422650883 0.886286112596045 MirTarget;TargetScan -0.180942442557432 6.54309893297213e-11 NA NA NA hsa-miR-142-5p CADM1 -1.44575553250033 1.18797044680592e-13 -0.0259171422650883 0.886286112596045 PITA -0.278588729976824 9.10350873167137e-11 NA NA NA hsa-miR-15b-5p CADM1 0.230566941413564 0.0824765001857479 -0.0259171422650883 0.886286112596045 miRNATAP -0.222145100555823 0.000843130472602004 NA NA NA hsa-miR-16-5p CADM1 -0.398577235179603 0.000101598495180191 -0.0259171422650883 0.886286112596045 miRNAWalker2_validate;miRTarBase;miRNATAP -0.351472990260743 4.11170970179543e-05 NA NA NA hsa-miR-182-5p CADM1 1.96601340710222 4.39326175603633e-09 -0.0259171422650883 0.886286112596045 miRNATAP -0.113024578325019 1.00354596466421e-05 24445397 TGF β upregulates miR 182 expression to promote gallbladder cancer metastasis by targeting CADM1; We further identified that the cell adhesion molecule1 CADM1 is a new target gene of miR-182 miR-182 negatively regulates CADM1 expression in vitro and in vivo metastasis bladder cancer hsa-miR-200a-3p CADM1 -1.49949292595657 3.18410995256133e-05 -0.0259171422650883 0.886286112596045 MirTarget -0.121159716760271 4.62070105512191e-07 NA NA NA hsa-miR-200b-3p CADM1 -1.29335788099229 0.000268623234305059 -0.0259171422650883 0.886286112596045 TargetScan -0.129370028513733 1.04870664138077e-07 NA NA NA hsa-miR-23a-3p CADM1 -0.178875974460574 0.135978273540604 -0.0259171422650883 0.886286112596045 miRNATAP -0.392446616873003 7.73404784083936e-08 NA NA NA hsa-miR-27a-3p CADM1 -0.370807380415112 0.00875721956202713 -0.0259171422650883 0.886286112596045 MirTarget;miRNATAP -0.387223004854468 2.49885045365404e-10 NA NA NA hsa-miR-3200-3p CADM1 1.40312896232918 1.8232142177606e-07 -0.0259171422650883 0.886286112596045 MirTarget -0.147562621861044 1.10690066410518e-05 NA NA NA hsa-miR-324-3p CADM1 0.260348469146494 0.0506141704203545 -0.0259171422650883 0.886286112596045 PITA -0.339653105585805 2.33595562344215e-07 NA NA NA hsa-miR-335-3p CADM1 -0.275199247483111 0.106629165248783 -0.0259171422650883 0.886286112596045 mirMAP -0.163621249892861 0.00154930603985859 NA NA NA hsa-miR-338-3p CADM1 0.543135607704581 0.00461167747143826 -0.0259171422650883 0.886286112596045 PITA;miRanda -0.203440438315238 7.85475549596642e-06 NA NA NA hsa-miR-342-3p CADM1 -0.319677314984262 0.0449813878317147 -0.0259171422650883 0.886286112596045 PITA;miRanda -0.306281963411538 2.00546715390404e-08 NA NA NA hsa-miR-421 CADM1 0.941856334694081 6.12167297054077e-08 -0.0259171422650883 0.886286112596045 miRanda -0.236233278285507 2.00875551121341e-06 NA NA NA hsa-miR-424-5p CADM1 -2.62653257498508 2.38997974737991e-50 -0.0259171422650883 0.886286112596045 miRNATAP -0.117931205622277 0.00767419172218007 NA NA NA hsa-miR-429 CADM1 -1.40262535827285 6.93982219171912e-05 -0.0259171422650883 0.886286112596045 miRNATAP -0.135693944652143 4.24431783648787e-08 NA NA NA hsa-miR-484 CADM1 0.0857240033709656 0.453982056282229 -0.0259171422650883 0.886286112596045 miRNAWalker2_validate -0.244309160200707 0.00163363911531927 NA NA NA hsa-miR-495-3p CADM1 -0.751193061269953 0.00388779118736635 -0.0259171422650883 0.886286112596045 MirTarget -0.118871315315649 0.000423248656888898 NA NA NA hsa-miR-501-3p CADM1 0.999540908940094 2.77358485581974e-11 -0.0259171422650883 0.886286112596045 PITA;TargetScan -0.183017575406376 0.00142006848560135 NA NA NA hsa-miR-590-5p CADM1 -0.103355559980404 0.310027295317092 -0.0259171422650883 0.886286112596045 PITA;miRanda;miRNATAP -0.337569664426359 0.000107788062390819 NA NA NA hsa-miR-92b-3p CADM1 0.220374930803974 0.296187538889092 -0.0259171422650883 0.886286112596045 miRNATAP -0.338741765487117 4.20058319691383e-17 NA NA NA hsa-miR-106b-5p CALD1 0.648901865047099 8.24870862047885e-09 -0.530621733887527 1.64156095327975e-08 miRNATAP -0.305997282669909 1.05649824896225e-14 NA NA NA hsa-miR-107 CALD1 0.241662461253461 0.0170788899505389 -0.530621733887527 1.64156095327975e-08 miRanda -0.131022829423649 0.00458542883113489 NA NA NA hsa-miR-15a-5p CALD1 0.349521211668244 0.000770735998804736 -0.530621733887527 1.64156095327975e-08 miRNAWalker2_validate -0.174506640820017 9.41291417619924e-05 NA NA NA hsa-miR-16-2-3p CALD1 -0.0336420826463706 0.805158952566973 -0.530621733887527 1.64156095327975e-08 mirMAP -0.159443022542642 2.66836537680272e-06 NA NA NA hsa-miR-17-5p CALD1 0.698861147045461 2.43854106455398e-05 -0.530621733887527 1.64156095327975e-08 TargetScan;miRNATAP -0.229193156420531 1.17757400625918e-17 NA NA NA hsa-miR-20a-5p CALD1 0.854326758727003 5.04256669663285e-07 -0.530621733887527 1.64156095327975e-08 miRNATAP -0.195440267483236 9.46993586193112e-14 NA NA NA hsa-miR-20b-5p CALD1 0.457668023910379 0.0285865211936156 -0.530621733887527 1.64156095327975e-08 miRNATAP -0.102403624151832 3.25316355225017e-06 NA NA NA hsa-miR-21-5p CALD1 1.51084295924322 1.54551622173259e-34 -0.530621733887527 1.64156095327975e-08 miRNAWalker2_validate;MirTarget -0.273877053450713 3.45477925002901e-16 NA NA NA hsa-miR-32-3p CALD1 0.219109440121582 0.207217051619543 -0.530621733887527 1.64156095327975e-08 MirTarget -0.124703256734462 5.58573418750042e-06 NA NA NA hsa-miR-338-3p CALD1 0.543135607704581 0.00461167747143826 -0.530621733887527 1.64156095327975e-08 miRanda -0.103174604545794 1.7254902974257e-05 NA NA NA hsa-miR-361-5p CALD1 0.233202959858696 0.00961572812255327 -0.530621733887527 1.64156095327975e-08 miRanda;miRNATAP -0.201066561885716 0.000108363680153745 NA NA NA hsa-miR-421 CALD1 0.941856334694081 6.12167297054077e-08 -0.530621733887527 1.64156095327975e-08 miRanda -0.18218809368466 1.54974521393451e-12 NA NA NA hsa-miR-484 CALD1 0.0857240033709656 0.453982056282229 -0.530621733887527 1.64156095327975e-08 PITA -0.139855365189866 0.000612835841051053 NA NA NA hsa-miR-501-3p CALD1 0.999540908940094 2.77358485581974e-11 -0.530621733887527 1.64156095327975e-08 TargetScan;miRNATAP -0.143303348154554 1.77738143682688e-06 NA NA NA hsa-miR-590-5p CALD1 -0.103355559980404 0.310027295317092 -0.530621733887527 1.64156095327975e-08 miRanda -0.16579049844998 0.000311943707636523 NA NA NA hsa-miR-93-5p CALD1 1.39518349670953 2.84167728726712e-25 -0.530621733887527 1.64156095327975e-08 miRNATAP -0.233952147352828 1.74669300112761e-13 NA NA NA hsa-miR-107 CALU 0.241662461253461 0.0170788899505389 0.322728190111391 0.000943151327461812 MirTarget;PITA;miRanda -0.16100764872729 0.000666358250186205 NA NA NA hsa-miR-122-5p CALU -1.23907441373955 4.42181244888642e-06 0.322728190111391 0.000943151327461812 miRNAWalker2_validate -0.139405227951435 1.14824050504832e-16 NA NA NA hsa-miR-125b-2-3p CALU -1.6609436107315 5.71534047969855e-18 0.322728190111391 0.000943151327461812 MirTarget -0.126925343638849 6.5498044407796e-08 NA NA NA hsa-miR-126-5p CALU -0.428561469405594 6.6035585844222e-05 0.322728190111391 0.000943151327461812 MirTarget -0.128353541023249 0.00382446522009621 NA NA NA hsa-miR-23b-3p CALU -0.530561587109023 5.43807206823652e-07 0.322728190111391 0.000943151327461812 mirMAP -0.177656493290802 6.73520475867371e-05 NA NA NA hsa-miR-29c-3p CALU -1.4367517608807 1.61767774905781e-21 0.322728190111391 0.000943151327461812 MirTarget -0.130411391006099 1.27281332352624e-05 NA NA NA hsa-miR-30b-5p CALU -0.54056186708617 2.44688760798341e-05 0.322728190111391 0.000943151327461812 MirTarget -0.118469443552983 0.00136183728012661 NA NA NA hsa-miR-30d-3p CALU -0.120562286038759 0.329549534782125 0.322728190111391 0.000943151327461812 MirTarget -0.152473170134085 7.86397469766751e-05 NA NA NA hsa-miR-33a-3p CALU -0.683025859637737 1.01106097756419e-05 0.322728190111391 0.000943151327461812 mirMAP -0.124225477431317 4.49352438103337e-05 NA NA NA hsa-miR-125a-3p CAP2 -0.841683158494395 3.51202687176603e-05 2.07199486258754 2.16096186415872e-27 miRanda -0.269226691017343 3.93993311510736e-08 NA NA NA hsa-miR-139-5p CAP2 -2.11299531796557 8.16407076415038e-28 2.07199486258754 2.16096186415872e-27 miRanda -0.203377603844363 2.12974771954628e-05 NA NA NA hsa-miR-193a-3p CAP2 -0.117675551589896 0.309391958208578 2.07199486258754 2.16096186415872e-27 miRanda -0.237911671180417 0.00607783248055746 NA NA NA hsa-miR-335-3p CAP2 -0.275199247483111 0.106629165248783 2.07199486258754 2.16096186415872e-27 mirMAP -0.27222908430861 2.65254555020711e-06 NA NA NA hsa-miR-338-5p CAP2 -0.221898432884726 0.252390988727086 2.07199486258754 2.16096186415872e-27 PITA -0.144035569521832 0.00533737550940341 NA NA NA hsa-miR-342-3p CAP2 -0.319677314984262 0.0449813878317147 2.07199486258754 2.16096186415872e-27 miRanda -0.28699627223581 3.70165951043776e-06 NA NA NA hsa-miR-429 CAP2 -1.40262535827285 6.93982219171912e-05 2.07199486258754 2.16096186415872e-27 miRanda -0.189256057283694 8.24801863977448e-12 NA NA NA hsa-miR-628-5p CAP2 -0.714131904567584 3.9911900261429e-08 2.07199486258754 2.16096186415872e-27 miRNATAP -0.197628914438062 0.00905928257853057 NA NA NA hsa-miR-139-5p CAPG -2.11299531796557 8.16407076415038e-28 1.1938845094456 1.58709718261221e-06 miRanda -0.499323362532113 1.84933740870131e-18 NA NA NA hsa-miR-148a-5p CD44 -0.767626696027761 1.08359477494797e-06 -0.0861213298199726 0.717927779502077 mirMAP -0.310480738209005 1.83991271476076e-05 23861222 In MHCC97H and MHCC97L cells over-expression of miR-148a blocked the EMT process attenuated the expression of CD90 and CD44 biomarkers for liver cancer stem cells and inhibited their migratory capacity liver cancer hsa-miR-27b-3p CD44 -0.823491817819754 9.20935302746823e-14 -0.0861213298199726 0.717927779502077 miRNATAP -0.346982595786675 0.000695530690953447 NA NA NA hsa-miR-28-5p CD44 -0.430964830599964 2.67367257252925e-06 -0.0861213298199726 0.717927779502077 miRanda -0.446289459647564 0.00040614855549503 NA NA NA hsa-miR-30c-1-3p CD44 -1.39373825444537 6.39912952911454e-17 -0.0861213298199726 0.717927779502077 MirTarget -0.316128842723998 2.68996369673779e-06 NA NA NA hsa-miR-30e-3p CD44 -1.20845647373031 3.10263633528203e-25 -0.0861213298199726 0.717927779502077 mirMAP -0.332724751374523 0.00040233905159745 NA NA NA hsa-miR-33a-3p CD44 -0.683025859637737 1.01106097756419e-05 -0.0861213298199726 0.717927779502077 mirMAP -0.331817989656265 7.28798873684555e-06 NA NA NA hsa-miR-340-5p CD44 -0.00477614531381576 0.968502722773791 -0.0861213298199726 0.717927779502077 mirMAP -0.402052693632312 2.87619052606118e-05 NA NA NA hsa-miR-616-5p CD44 0.150569904638223 0.402836556304524 -0.0861213298199726 0.717927779502077 mirMAP -0.2443077442705 0.000152979102521287 NA NA NA hsa-miR-362-3p CD59 0.814007335895913 2.00108618836568e-09 0.0387046892902401 0.692657719471883 MirTarget -0.107914937512866 0.0017136325593209 NA NA NA hsa-miR-590-3p CD59 -0.473167498047808 1.76652934637227e-05 0.0387046892902401 0.692657719471883 mirMAP -0.175919670444087 3.95153886373792e-05 NA NA NA hsa-miR-92a-3p CD59 0.212391012518195 0.134292268089997 0.0387046892902401 0.692657719471883 miRNAWalker2_validate -0.292060044285793 1.10309393101432e-19 NA NA NA hsa-miR-144-5p CDH11 -1.54604938792018 1.06886492586611e-10 0.643182936892396 0.0298934986153023 mirMAP -0.194743527433783 0.000933998612639129 NA NA NA hsa-miR-32-3p CDH11 0.219109440121582 0.207217051619543 0.643182936892396 0.0298934986153023 mirMAP -0.433193347488099 3.69428996576939e-07 NA NA NA hsa-miR-616-5p CDH11 0.150569904638223 0.402836556304524 0.643182936892396 0.0298934986153023 mirMAP -0.331311971104318 3.67086360288697e-05 NA NA NA hsa-miR-144-3p CDH6 -2.97536914478815 6.00546047309683e-28 -0.011269183333376 0.966488319003756 MirTarget -0.157641162895434 0.000424112339995811 NA NA NA hsa-miR-204-5p CDH6 -0.537962150012103 0.0330895493358849 -0.011269183333376 0.966488319003756 mirMAP -0.258908966061738 4.0880259812606e-07 NA NA NA hsa-miR-33a-3p CDH6 -0.683025859637737 1.01106097756419e-05 -0.011269183333376 0.966488319003756 mirMAP -0.315389110970214 0.000159581665525528 NA NA NA hsa-miR-374a-5p CDH6 0.016390363747302 0.869784217438621 -0.011269183333376 0.966488319003756 mirMAP -0.486237114104457 0.000222886603517395 NA NA NA hsa-miR-374b-5p CDH6 -0.307538028546424 0.0030079617545972 -0.011269183333376 0.966488319003756 mirMAP -0.343239865188325 0.00675765626046292 NA NA NA hsa-miR-502-3p CDH6 0.659598854007546 3.01316453996423e-08 -0.011269183333376 0.966488319003756 MirTarget -0.342500079137392 0.00157796923228807 NA NA NA hsa-miR-576-5p CDH6 -0.377452008285847 0.00470735657343984 -0.011269183333376 0.966488319003756 PITA;mirMAP -0.255757150016276 0.00901498862814946 NA NA NA hsa-miR-616-5p CDH6 0.150569904638223 0.402836556304524 -0.011269183333376 0.966488319003756 mirMAP -0.335410033050551 3.48838095819374e-06 NA NA NA hsa-miR-139-5p COL11A1 -2.11299531796557 8.16407076415038e-28 1.54551268520343 0.000618478933133262 miRanda -0.47590688141087 7.46428085697108e-06 NA NA NA hsa-miR-26b-5p COL11A1 -1.10804856399744 4.14176110314282e-22 1.54551268520343 0.000618478933133262 miRNATAP -0.580915016569282 0.0016001089983445 NA NA NA hsa-miR-32-3p COL11A1 0.219109440121582 0.207217051619543 1.54551268520343 0.000618478933133262 miRNATAP -0.412893287954869 0.00171750337667375 NA NA NA hsa-miR-32-5p COL11A1 0.0806126674664016 0.548984992497432 1.54551268520343 0.000618478933133262 MirTarget -0.997592922415954 8.45672460229002e-10 NA NA NA hsa-miR-374a-3p COL11A1 -0.207171354826929 0.0623494608399903 1.54551268520343 0.000618478933133262 MirTarget;miRNATAP -0.648604038852927 0.00120231176173461 NA NA NA hsa-miR-374a-5p COL11A1 0.016390363747302 0.869784217438621 1.54551268520343 0.000618478933133262 mirMAP -0.843905533262393 0.000156569874041865 NA NA NA hsa-miR-374b-5p COL11A1 -0.307538028546424 0.0030079617545972 1.54551268520343 0.000618478933133262 mirMAP -0.811466213098043 0.00014899903850646 NA NA NA hsa-miR-455-3p COL11A1 -1.3998033821095 5.72010709806871e-17 1.54551268520343 0.000618478933133262 MirTarget;PITA -0.758640755066561 1.38013331414381e-09 NA NA NA hsa-miR-107 COL12A1 0.241662461253461 0.0170788899505389 -0.132213117983103 0.570362613274865 miRanda -0.756747132553278 6.68111502174221e-12 NA NA NA hsa-miR-1180-3p COL12A1 1.13535217859875 1.17286173228245e-09 -0.132213117983103 0.570362613274865 MirTarget -0.247764954775617 2.87531005308409e-05 NA NA NA hsa-miR-15a-5p COL12A1 0.349521211668244 0.000770735998804736 -0.132213117983103 0.570362613274865 MirTarget;miRNATAP -0.437667227253736 5.96515706718496e-05 NA NA NA hsa-miR-17-3p COL12A1 0.410352776142368 0.00422200500748636 -0.132213117983103 0.570362613274865 MirTarget;miRNATAP -0.35616026263185 5.64589449417937e-06 NA NA NA hsa-miR-30d-3p COL12A1 -0.120562286038759 0.329549534782125 -0.132213117983103 0.570362613274865 miRNATAP -0.238119690700955 0.00995520077475122 NA NA NA hsa-miR-32-5p COL12A1 0.0806126674664016 0.548984992497432 -0.132213117983103 0.570362613274865 miRNATAP -0.430296423209762 2.8666663710963e-07 NA NA NA hsa-miR-34a-5p COL12A1 1.03694231790865 5.74864019540594e-14 -0.132213117983103 0.570362613274865 MirTarget;miRNATAP -0.25473884489828 0.00140704114035112 NA NA NA hsa-miR-502-3p COL12A1 0.659598854007546 3.01316453996423e-08 -0.132213117983103 0.570362613274865 PITA -0.258300788989954 0.00614932109100077 NA NA NA hsa-miR-532-5p COL12A1 1.02729546510601 9.93318913966636e-16 -0.132213117983103 0.570362613274865 PITA -0.492380062453711 5.69773770519404e-09 NA NA NA hsa-miR-590-5p COL12A1 -0.103355559980404 0.310027295317092 -0.132213117983103 0.570362613274865 PITA;miRanda -0.427953989867206 0.00013585736305565 NA NA NA hsa-miR-92a-3p COL12A1 0.212391012518195 0.134292268089997 -0.132213117983103 0.570362613274865 miRNATAP -0.333231589481705 2.95869834961459e-05 NA NA NA hsa-miR-107 COL1A1 0.241662461253461 0.0170788899505389 0.826702197173396 0.00648724292232758 PITA;miRanda -1.03604844961437 6.189177258338e-13 NA NA NA hsa-miR-193a-5p COL1A1 -0.472805720224262 1.24962968905481e-05 0.826702197173396 0.00648724292232758 PITA;TargetScan;miRNATAP -0.631963739355247 3.30700752875273e-06 NA NA NA hsa-miR-20a-5p COL1A1 0.854326758727003 5.04256669663285e-07 0.826702197173396 0.00648724292232758 mirMAP -0.233621814946948 0.00679703428396713 NA NA NA hsa-miR-23b-5p COL1A1 -1.05289229952702 7.22203199173865e-13 0.826702197173396 0.00648724292232758 mirMAP -0.273119936989386 0.00677641533350269 NA NA NA hsa-miR-30b-3p COL1A1 -0.439724365151373 0.000947180503583586 0.826702197173396 0.00648724292232758 miRNATAP -0.407003170758284 0.000252249930807467 NA NA NA hsa-miR-30e-3p COL1A1 -1.20845647373031 3.10263633528203e-25 0.826702197173396 0.00648724292232758 mirMAP -0.436158045118392 0.000287836135145749 NA NA NA hsa-miR-532-3p COL1A1 0.297601533259956 0.014632205884815 0.826702197173396 0.00648724292232758 PITA;miRNATAP -0.459574968886081 0.000161776311559917 NA NA NA hsa-miR-616-5p COL1A1 0.150569904638223 0.402836556304524 0.826702197173396 0.00648724292232758 mirMAP;miRNATAP -0.460861872336035 1.70679592021185e-08 NA NA NA hsa-miR-26b-5p COL1A2 -1.10804856399744 4.14176110314282e-22 0.58018696776109 0.0267399288126224 MirTarget;miRNATAP -0.336616912489242 0.0015435755362445 NA NA NA hsa-miR-30d-3p COL1A2 -0.120562286038759 0.329549534782125 0.58018696776109 0.0267399288126224 MirTarget -0.270934115842966 0.00928784242471402 NA NA NA hsa-miR-30e-3p COL1A2 -1.20845647373031 3.10263633528203e-25 0.58018696776109 0.0267399288126224 MirTarget -0.281145660318855 0.00682336575635351 NA NA NA hsa-miR-32-3p COL1A2 0.219109440121582 0.207217051619543 0.58018696776109 0.0267399288126224 miRNATAP -0.37279076503956 7.6563506038813e-07 NA NA NA hsa-miR-32-5p COL1A2 0.0806126674664016 0.548984992497432 0.58018696776109 0.0267399288126224 MirTarget;miRNATAP -0.613101144317773 5.76821580215829e-11 NA NA NA hsa-miR-33a-3p COL1A2 -0.683025859637737 1.01106097756419e-05 0.58018696776109 0.0267399288126224 MirTarget -0.501154698930155 5.09589827659522e-10 NA NA NA hsa-miR-7-1-3p COL1A2 -0.569105143287799 1.85297665041424e-05 0.58018696776109 0.0267399288126224 mirMAP -0.264273750473028 0.00576750957648269 NA NA NA hsa-miR-92a-3p COL1A2 0.212391012518195 0.134292268089997 0.58018696776109 0.0267399288126224 MirTarget;miRNATAP -0.312053884384404 0.000544719042919194 NA NA NA hsa-miR-107 COL3A1 0.241662461253461 0.0170788899505389 -0.474803338347196 0.0877747183989073 miRanda -1.02151197386126 5.63457177228944e-15 NA NA NA hsa-miR-128-3p COL3A1 0.289735108018712 0.0114419474207889 -0.474803338347196 0.0877747183989073 MirTarget -0.437421245954586 0.000224010447746262 NA NA NA hsa-miR-186-5p COL3A1 -0.060103391373687 0.535288717081205 -0.474803338347196 0.0877747183989073 miRNATAP -0.510774989329246 0.000298585960153161 NA NA NA hsa-miR-28-5p COL3A1 -0.430964830599964 2.67367257252925e-06 -0.474803338347196 0.0877747183989073 miRanda -0.495560300653521 0.000787015281731695 NA NA NA hsa-miR-455-3p COL3A1 -1.3998033821095 5.72010709806871e-17 -0.474803338347196 0.0877747183989073 miRNAWalker2_validate -0.362011875342883 2.90736869784078e-06 NA NA NA hsa-miR-590-5p COL3A1 -0.103355559980404 0.310027295317092 -0.474803338347196 0.0877747183989073 miRanda -0.514985748428867 0.000123057232668985 NA NA NA hsa-miR-148a-3p COL4A1 -0.748702855596996 3.93313343865641e-07 1.64595918385092 3.29766696573805e-22 miRNATAP -0.506696445918838 1.45523526380931e-19 NA NA NA hsa-miR-193b-3p COL4A1 -0.166697207281748 0.272022543069482 1.64595918385092 3.29766696573805e-22 miRNAWalker2_validate -0.218530092845592 0.000144043698376859 NA NA NA hsa-miR-29c-3p COL4A1 -1.4367517608807 1.61767774905781e-21 1.64595918385092 3.29766696573805e-22 miRNAWalker2_validate;miRTarBase;miRNATAP -0.17365265771026 0.00160253083531795 NA NA NA hsa-miR-590-3p COL4A1 -0.473167498047808 1.76652934637227e-05 1.64595918385092 3.29766696573805e-22 miRanda -0.232842070891326 0.00321669636636402 NA NA NA hsa-miR-590-5p COL4A1 -0.103355559980404 0.310027295317092 1.64595918385092 3.29766696573805e-22 miRanda;miRNATAP -0.403715680850443 2.64148852714533e-06 NA NA NA hsa-miR-99a-5p COL4A1 -1.51481656384839 3.93230057259529e-14 1.64595918385092 3.29766696573805e-22 miRNAWalker2_validate -0.194902289048293 3.21789355543509e-06 NA NA NA hsa-miR-26b-5p COL4A2 -1.10804856399744 4.14176110314282e-22 1.44307871157488 7.7234079265155e-18 miRNAWalker2_validate -0.427711605173566 8.4579800793199e-10 NA NA NA hsa-miR-29c-3p COL4A2 -1.4367517608807 1.61767774905781e-21 1.44307871157488 7.7234079265155e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.147672102686362 0.00605514035830943 NA NA NA hsa-miR-30c-1-3p COL4A2 -1.39373825444537 6.39912952911454e-17 1.44307871157488 7.7234079265155e-18 MirTarget -0.299314528692518 1.02267945249468e-09 NA NA NA hsa-miR-107 COL5A1 0.241662461253461 0.0170788899505389 0.157717020532577 0.575064051526938 miRanda -1.00270541815027 3.56996559402072e-14 NA NA NA hsa-miR-192-5p COL5A1 -0.50188499512787 0.00344713341196035 0.157717020532577 0.575064051526938 miRNATAP -0.69106442525522 1.23228181782937e-19 NA NA NA hsa-miR-32-5p COL5A1 0.0806126674664016 0.548984992497432 0.157717020532577 0.575064051526938 miRNATAP -0.660569494242868 4.43101648956059e-11 NA NA NA hsa-miR-7-1-3p COL5A1 -0.569105143287799 1.85297665041424e-05 0.157717020532577 0.575064051526938 mirMAP -0.292176300994666 0.00437414361369826 NA NA NA hsa-miR-92a-3p COL5A1 0.212391012518195 0.134292268089997 0.157717020532577 0.575064051526938 miRNATAP -0.301525479463462 0.00184297188591645 NA NA NA hsa-miR-148a-5p COL5A2 -0.767626696027761 1.08359477494797e-06 0.523957991319594 0.00488074596388077 MirTarget -0.431115785321945 7.43046788070165e-15 NA NA NA hsa-miR-29a-3p COL5A2 -0.856762511178136 4.65330336378459e-12 0.523957991319594 0.00488074596388077 MirTarget;miRNATAP -0.343713613899254 1.39604626550331e-06 NA NA NA hsa-miR-29b-3p COL5A2 -0.348885528720517 0.0121441341291285 0.523957991319594 0.00488074596388077 MirTarget;miRNATAP -0.230119720819941 0.000427176138546833 NA NA NA hsa-miR-29c-3p COL5A2 -1.4367517608807 1.61767774905781e-21 0.523957991319594 0.00488074596388077 MirTarget;miRNATAP -0.362723299809565 1.16833536591495e-10 NA NA NA hsa-miR-34a-5p COL5A2 1.03694231790865 5.74864019540594e-14 0.523957991319594 0.00488074596388077 MirTarget -0.219312055701001 0.000604452427539009 NA NA NA hsa-miR-455-5p COL5A2 -0.270546034117157 0.0581320703577731 0.523957991319594 0.00488074596388077 miRanda -0.185656765062945 0.00365335222424077 NA NA NA hsa-miR-885-5p COL5A2 -0.940994379567566 0.00118729865914986 0.523957991319594 0.00488074596388077 PITA;miRNATAP -0.121531536690919 8.8630906262827e-05 NA NA NA hsa-miR-429 COL5A3 -1.40262535827285 6.93982219171912e-05 1.30611641058869 3.36127524906538e-06 miRanda -0.263690960281317 7.74884853307229e-12 NA NA NA hsa-miR-146b-5p COL6A3 0.419719546795449 0.0457375823220155 0.169833671007575 0.432293683806163 miRanda -0.130033763284282 0.00943159485447041 NA NA NA hsa-miR-28-5p COL6A3 -0.430964830599964 2.67367257252925e-06 0.169833671007575 0.432293683806163 miRanda -0.367874691394583 0.00133476304471087 NA NA NA hsa-miR-29c-3p COL7A1 -1.4367517608807 1.61767774905781e-21 2.91025161716558 1.66351001849965e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.505811148582802 4.93285925553647e-05 NA NA NA hsa-miR-3065-3p COL7A1 -1.04244468016704 4.60743424372577e-05 2.91025161716558 1.66351001849965e-13 MirTarget;miRNATAP -0.219166671451556 0.00432805700430565 NA NA NA hsa-miR-574-3p COL7A1 -0.7502874612284 9.60341504490736e-12 2.91025161716558 1.66351001849965e-13 miRNATAP -0.596791515188716 0.000723612273165997 NA NA NA hsa-miR-194-3p COL8A2 -0.772747277805343 2.9537465170191e-05 -0.974645375504798 0.000903968905923106 MirTarget -0.538849319459217 7.6442373376113e-13 NA NA NA hsa-miR-20a-5p COL8A2 0.854326758727003 5.04256669663285e-07 -0.974645375504798 0.000903968905923106 mirMAP -0.233448175322622 0.00524062360588325 NA NA NA hsa-miR-142-3p COPA -1.4243101967815 1.92609481097765e-14 0.454205253695243 2.21022363190047e-07 miRanda -0.113745456824707 3.0739406358338e-07 NA NA NA hsa-miR-542-3p COPA -1.31351015149842 3.64642423288576e-22 0.454205253695243 2.21022363190047e-07 miRanda -0.130170579081533 1.51203739721245e-05 NA NA NA hsa-miR-26b-5p CRLF1 -1.10804856399744 4.14176110314282e-22 0.907395077826345 0.0171607709060156 miRNAWalker2_validate -0.708657268994378 3.97351989589605e-06 NA NA NA hsa-miR-30c-5p CTHRC1 -0.432111642767632 0.000159764714931007 3.17822009022244 8.77701727783127e-20 MirTarget -0.434766973376751 0.00530609194063901 NA NA NA hsa-miR-30e-5p CTHRC1 -0.627815042856657 3.02205690184908e-10 3.17822009022244 8.77701727783127e-20 MirTarget -1.26947796546048 1.62346037971745e-13 NA NA NA hsa-miR-3607-3p CTHRC1 -2.15518588554493 1.03390728226728e-23 3.17822009022244 8.77701727783127e-20 MirTarget;miRNATAP -0.476610417626177 6.17956959806093e-10 NA NA NA hsa-miR-374a-5p CXCL1 0.016390363747302 0.869784217438621 -1.48466934421038 0.000829911962758382 mirMAP -0.944799376929238 1.60017135575022e-05 NA NA NA hsa-miR-186-5p CXCL12 -0.060103391373687 0.535288717081205 -3.59146357807385 1.03718574480494e-35 mirMAP -0.449019463206294 0.00507324748951651 NA NA NA hsa-miR-221-3p CXCL12 1.12244756358612 3.48370308238012e-13 -3.59146357807385 1.03718574480494e-35 MirTarget -0.313249809796118 0.00117662736734837 NA NA NA hsa-miR-222-3p CXCL12 1.08574156066353 1.76407192348131e-11 -3.59146357807385 1.03718574480494e-35 MirTarget -0.247137611961592 0.00776299898035471 NA NA NA hsa-miR-301a-3p CXCL12 0.842910511640361 1.43446467417891e-06 -3.59146357807385 1.03718574480494e-35 miRNATAP -0.286138029073657 0.00094887575133379 NA NA NA hsa-miR-30d-5p CXCL12 0.718283816348023 2.47422074061352e-08 -3.59146357807385 1.03718574480494e-35 mirMAP -0.461190739697146 8.16546710367942e-05 NA NA NA hsa-miR-362-3p CXCL12 0.814007335895913 2.00108618836568e-09 -3.59146357807385 1.03718574480494e-35 miRanda -0.488292026707857 9.8400106445751e-06 NA NA NA hsa-miR-532-5p CXCL12 1.02729546510601 9.93318913966636e-16 -3.59146357807385 1.03718574480494e-35 PITA;miRNATAP -0.806782265016543 1.01736062721927e-12 NA NA NA hsa-miR-17-5p CXCL6 0.698861147045461 2.43854106455398e-05 -3.43495201431017 2.61831723964962e-09 MirTarget -0.694439626842758 4.93052189645479e-05 NA NA NA hsa-miR-20a-5p CXCL6 0.854326758727003 5.04256669663285e-07 -3.43495201431017 2.61831723964962e-09 MirTarget -0.840433867564058 3.46698534970176e-07 NA NA NA hsa-miR-362-3p CXCL6 0.814007335895913 2.00108618836568e-09 -3.43495201431017 2.61831723964962e-09 miRanda -0.591268501012066 0.00448276735585997 NA NA NA hsa-miR-93-5p CXCL6 1.39518349670953 2.84167728726712e-25 -3.43495201431017 2.61831723964962e-09 MirTarget -0.774187164688315 0.000115232676422954 NA NA NA hsa-miR-331-5p CYR61 0.213759185384356 0.120772399478646 -2.25818126501287 1.19881811706656e-28 miRNATAP -0.336232398078058 1.39975191687155e-05 NA NA NA hsa-miR-139-5p DAB2 -2.11299531796557 8.16407076415038e-28 -0.0812678108323723 0.659390389044208 miRanda -0.11332759076699 0.00900759583877607 NA NA NA hsa-miR-20a-5p DAB2 0.854326758727003 5.04256669663285e-07 -0.0812678108323723 0.659390389044208 MirTarget;miRNATAP -0.149841610964144 0.00403571251642021 NA NA NA hsa-miR-28-5p DAB2 -0.430964830599964 2.67367257252925e-06 -0.0812678108323723 0.659390389044208 miRanda -0.399466103084327 4.04683201078494e-05 NA NA NA hsa-miR-30c-1-3p DAB2 -1.39373825444537 6.39912952911454e-17 -0.0812678108323723 0.659390389044208 MirTarget -0.141724536289785 0.00698027965115797 NA NA NA hsa-miR-548b-3p DAB2 -0.0203576084717134 0.930819503166956 -0.0812678108323723 0.659390389044208 PITA;miRNATAP -0.222381403542602 5.90065357917947e-09 NA NA NA hsa-miR-186-5p DCN -0.060103391373687 0.535288717081205 -4.16086251487049 1.15620570061837e-21 mirMAP -0.854956418637479 0.00023962626758074 NA NA NA hsa-miR-374b-3p DCN -0.137420230218985 0.305318192448799 -4.16086251487049 1.15620570061837e-21 MirTarget -0.443951014167465 0.00820846134725373 NA NA NA hsa-miR-421 DCN 0.941856334694081 6.12167297054077e-08 -4.16086251487049 1.15620570061837e-21 miRanda -0.713744467424654 1.22619058359562e-08 NA NA NA hsa-miR-29a-3p DKK1 -0.856762511178136 4.65330336378459e-12 2.53841627649576 5.46380849566482e-06 miRNAWalker2_validate;miRTarBase -1.2101636118785 1.65540639532224e-08 NA NA NA hsa-miR-107 DPYSL3 0.241662461253461 0.0170788899505389 -0.0196686457793489 0.921328374853133 miRanda -0.607477655688057 1.30468706135881e-10 NA NA NA hsa-miR-197-3p DPYSL3 -0.245033899783728 0.0362223947695203 -0.0196686457793489 0.921328374853133 miRNAWalker2_validate -0.32453791213082 9.08551821118144e-05 NA NA NA hsa-miR-25-3p DPYSL3 0.633062563556379 3.68686354834328e-10 -0.0196686457793489 0.921328374853133 mirMAP -0.314684972000643 0.000879538578862047 NA NA NA hsa-miR-423-3p DPYSL3 0.302157659154355 0.000669907339064765 -0.0196686457793489 0.921328374853133 miRNAWalker2_validate -0.418964768482652 0.000132101866377153 NA NA NA hsa-miR-532-3p DPYSL3 0.297601533259956 0.014632205884815 -0.0196686457793489 0.921328374853133 miRNATAP -0.433114563124944 3.78825283096699e-08 NA NA NA hsa-miR-589-5p DPYSL3 1.18593770505086 1.01781241960531e-22 -0.0196686457793489 0.921328374853133 mirMAP -0.338196065473144 8.0098725048561e-06 NA NA NA hsa-miR-616-5p DPYSL3 0.150569904638223 0.402836556304524 -0.0196686457793489 0.921328374853133 mirMAP -0.384907265448694 2.65305380100177e-13 NA NA NA hsa-miR-106b-5p DST 0.648901865047099 8.24870862047885e-09 -0.376077518150669 0.00154802384484121 mirMAP -0.134796358954952 0.008250877910236 NA NA NA hsa-miR-146b-5p DST 0.419719546795449 0.0457375823220155 -0.376077518150669 0.00154802384484121 miRanda -0.115846477778592 2.419088044855e-05 NA NA NA hsa-miR-15b-3p DST 0.238105490431193 0.0997721500357416 -0.376077518150669 0.00154802384484121 mirMAP -0.136603620216945 0.00067152634861283 NA NA NA hsa-miR-16-1-3p DST 0.392360028038559 0.00112481918108198 -0.376077518150669 0.00154802384484121 mirMAP -0.18995415884967 7.66358113375974e-05 NA NA NA hsa-miR-18a-5p DST 0.918028187958706 1.90229510425322e-05 -0.376077518150669 0.00154802384484121 mirMAP -0.103322693090999 0.000106601972039761 NA NA NA hsa-miR-21-5p DST 1.51084295924322 1.54551622173259e-34 -0.376077518150669 0.00154802384484121 mirMAP -0.192141258894703 8.41432997112948e-06 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-29a-5p DST -0.113555908626946 0.349622266470788 -0.376077518150669 0.00154802384484121 mirMAP -0.168412440767367 0.000453603842685052 NA NA NA hsa-miR-30d-3p DST -0.120562286038759 0.329549534782125 -0.376077518150669 0.00154802384484121 mirMAP -0.153827415737988 0.00111319583486839 NA NA NA hsa-miR-330-3p DST -0.332364259424489 0.0316051913061459 -0.376077518150669 0.00154802384484121 mirMAP -0.101522266247196 0.00830447368492613 NA NA NA hsa-miR-330-5p DST 0.442231058604099 0.0053308560843808 -0.376077518150669 0.00154802384484121 miRanda;mirMAP -0.148497181075026 4.3969731081438e-05 NA NA NA hsa-miR-362-5p DST 0.717921690799312 1.68392734504524e-05 -0.376077518150669 0.00154802384484121 TargetScan;mirMAP -0.10463166733182 0.00241770652097328 NA NA NA hsa-miR-484 DST 0.0857240033709656 0.453982056282229 -0.376077518150669 0.00154802384484121 miRNAWalker2_validate -0.182447001868131 0.000345637176015638 NA NA NA hsa-miR-532-3p DST 0.297601533259956 0.014632205884815 -0.376077518150669 0.00154802384484121 mirMAP -0.141265755559385 0.00311230109361082 NA NA NA hsa-miR-532-5p DST 1.02729546510601 9.93318913966636e-16 -0.376077518150669 0.00154802384484121 mirMAP -0.182319350041687 3.01365091267101e-05 NA NA NA hsa-miR-590-5p DST -0.103355559980404 0.310027295317092 -0.376077518150669 0.00154802384484121 mirMAP -0.156190882199273 0.00675717654948339 NA NA NA hsa-miR-769-3p DST 0.618139013155289 0.000147293288426878 -0.376077518150669 0.00154802384484121 mirMAP -0.12412146478339 0.000623202908785868 NA NA NA hsa-miR-93-5p DST 1.39518349670953 2.84167728726712e-25 -0.376077518150669 0.00154802384484121 mirMAP -0.155398374231987 0.000130924526697948 NA NA NA hsa-miR-125a-3p ECM2 -0.841683158494395 3.51202687176603e-05 -1.26821765289594 1.34465361899479e-08 miRanda -0.298241856125234 4.47935195085186e-08 NA NA NA hsa-miR-142-3p ECM2 -1.4243101967815 1.92609481097765e-14 -1.26821765289594 1.34465361899479e-08 miRanda;miRNATAP -0.182397154908921 0.00152755238033944 NA NA NA hsa-miR-16-2-3p ECM2 -0.0336420826463706 0.805158952566973 -1.26821765289594 1.34465361899479e-08 mirMAP -0.527884924264275 4.02551175527759e-11 NA NA NA hsa-miR-320a ECM2 0.325285936317332 0.0221415065838824 -1.26821765289594 1.34465361899479e-08 miRanda -0.30416379514076 9.04804268326347e-05 NA NA NA hsa-miR-320b ECM2 0.0919652022571331 0.607981643616945 -1.26821765289594 1.34465361899479e-08 miRanda -0.306206616301237 6.75976790116245e-07 NA NA NA hsa-miR-323a-3p ECM2 -1.32152926898185 6.70089501458627e-05 -1.26821765289594 1.34465361899479e-08 MirTarget -0.190232052564214 8.81259323475826e-09 NA NA NA hsa-miR-331-5p ECM2 0.213759185384356 0.120772399478646 -1.26821765289594 1.34465361899479e-08 MirTarget -0.767097115041148 1.95732551921112e-23 NA NA NA hsa-miR-335-3p ECM2 -0.275199247483111 0.106629165248783 -1.26821765289594 1.34465361899479e-08 MirTarget -0.421253886678692 3.63100649037843e-11 NA NA NA hsa-miR-342-3p ECM2 -0.319677314984262 0.0449813878317147 -1.26821765289594 1.34465361899479e-08 miRanda -0.337135497295473 9.83473768573057e-07 NA NA NA hsa-miR-421 ECM2 0.941856334694081 6.12167297054077e-08 -1.26821765289594 1.34465361899479e-08 miRanda -0.503799049163981 1.12862162968497e-16 NA NA NA hsa-miR-452-3p ECM2 1.76909792952222 2.98172274671408e-10 -1.26821765289594 1.34465361899479e-08 MirTarget -0.146838902889065 0.000132186439835431 NA NA NA hsa-miR-590-5p ECM2 -0.103355559980404 0.310027295317092 -1.26821765289594 1.34465361899479e-08 miRanda -0.545288746041668 5.46436507635168e-07 NA NA NA hsa-miR-107 EDIL3 0.241662461253461 0.0170788899505389 1.37592153564406 0.000111390433401046 miRanda -0.849455732210562 8.27108731949586e-07 NA NA NA hsa-miR-32-3p EDIL3 0.219109440121582 0.207217051619543 1.37592153564406 0.000111390433401046 mirMAP -0.27402613292954 0.00856592688752839 NA NA NA hsa-miR-590-5p EDIL3 -0.103355559980404 0.310027295317092 1.37592153564406 0.000111390433401046 MirTarget;miRNATAP -0.479838678518355 0.00573774555579182 NA NA NA hsa-miR-128-3p EFEMP2 0.289735108018712 0.0114419474207889 -0.533923767772889 0.00370725121787012 miRNAWalker2_validate -0.283269529279181 0.000316479684680442 NA NA NA hsa-miR-421 ELN 0.941856334694081 6.12167297054077e-08 -1.09135790415174 0.00113402371931902 miRanda -0.39975487832859 1.66346856185047e-05 NA NA NA hsa-miR-423-5p ELN 0.698807775906485 1.02195196334612e-11 -1.09135790415174 0.00113402371931902 MirTarget -0.650810690031139 3.1704325559014e-05 NA NA NA hsa-miR-106a-5p FAS -0.464229535269236 0.009724944358047 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate;miRTarBase -0.302797529669468 5.79007536295077e-09 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-21-5p FAS 1.51084295924322 1.54551622173259e-34 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.345881974093154 8.950367188801e-07 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7 breast cancer hsa-miR-338-3p FAS 0.543135607704581 0.00461167747143826 -1.01888565147264 1.11378826495697e-07 miRanda -0.23029320652752 2.57971450360388e-06 NA NA NA hsa-miR-361-5p FAS 0.233202959858696 0.00961572812255327 -1.01888565147264 1.11378826495697e-07 miRanda -0.400344969968845 0.000164688479523076 NA NA NA hsa-miR-590-5p FAS -0.103355559980404 0.310027295317092 -1.01888565147264 1.11378826495697e-07 miRanda -0.564263807321375 1.14802968070722e-09 NA NA NA hsa-miR-98-5p FAS -0.0487189107419432 0.715911066732548 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.184416097033268 0.00981276415174906 NA NA NA hsa-miR-486-5p FBLN1 -1.77766890600022 2.9071717929922e-14 0.519106625712852 0.0766877972282645 miRanda -0.156742757677659 0.00808646147506206 NA NA NA hsa-miR-128-3p FBLN2 0.289735108018712 0.0114419474207889 -0.962046315732466 0.00450310175657185 MirTarget -0.392209187014933 0.00697401408881628 NA NA NA hsa-miR-616-5p FBLN5 0.150569904638223 0.402836556304524 -1.67254890182744 3.98872233856958e-10 miRNATAP -0.37058204876883 4.76752113394818e-07 NA NA NA hsa-miR-192-5p FBN1 -0.50188499512787 0.00344713341196035 0.042762327488989 0.844747911420757 miRNAWalker2_validate -0.450531498850048 6.18310358582424e-14 NA NA NA hsa-miR-19b-1-5p FBN1 -0.277804782598538 0.0783067794722916 0.042762327488989 0.844747911420757 mirMAP -0.178959773766797 0.00802337093288461 NA NA NA hsa-miR-25-3p FBN1 0.633062563556379 3.68686354834328e-10 0.042762327488989 0.844747911420757 mirMAP -0.317354722096188 0.00224472430445695 NA NA NA hsa-miR-32-3p FBN1 0.219109440121582 0.207217051619543 0.042762327488989 0.844747911420757 miRNATAP -0.35356866133975 1.45161144366859e-08 NA NA NA hsa-miR-361-5p FBN1 0.233202959858696 0.00961572812255327 0.042762327488989 0.844747911420757 mirMAP -0.609559463788885 2.39382798005885e-07 NA NA NA hsa-miR-374a-5p FBN1 0.016390363747302 0.869784217438621 0.042762327488989 0.844747911420757 mirMAP -0.442110637605019 3.58955922992756e-05 NA NA NA hsa-miR-374b-5p FBN1 -0.307538028546424 0.0030079617545972 0.042762327488989 0.844747911420757 mirMAP -0.431207602879236 2.59221928113384e-05 NA NA NA hsa-miR-421 FBN1 0.941856334694081 6.12167297054077e-08 0.042762327488989 0.844747911420757 mirMAP -0.199735465866398 0.000930879871313141 NA NA NA hsa-miR-92a-3p FBN1 0.212391012518195 0.134292268089997 0.042762327488989 0.844747911420757 mirMAP -0.293321351324856 8.91810772634385e-05 NA NA NA hsa-miR-101-3p FBN2 -1.48176407980989 3.98950707385704e-31 -0.531785057821196 0.0369269139070016 miRNAWalker2_validate;MirTarget;miRNATAP -0.276134853502378 0.00228249349897151 NA NA NA hsa-miR-107 FBN2 0.241662461253461 0.0170788899505389 -0.531785057821196 0.0369269139070016 miRanda -0.601226528449469 9.33387841652418e-07 NA NA NA hsa-miR-204-5p FBN2 -0.537962150012103 0.0330895493358849 -0.531785057821196 0.0369269139070016 MirTarget;miRNATAP -0.154656043745259 0.00165325439400122 NA NA NA hsa-miR-30d-5p FBN2 0.718283816348023 2.47422074061352e-08 -0.531785057821196 0.0369269139070016 miRNAWalker2_validate -0.251559821201505 0.00838013877699597 NA NA NA hsa-miR-21-5p FERMT2 1.51084295924322 1.54551622173259e-34 -1.17471907439772 6.50761494287311e-25 miRNAWalker2_validate -0.471357960010248 1.37679112814546e-30 NA NA NA hsa-miR-221-3p FERMT2 1.12244756358612 3.48370308238012e-13 -1.17471907439772 6.50761494287311e-25 MirTarget;miRNATAP -0.153189097329362 3.36111787442557e-05 NA NA NA hsa-miR-222-3p FERMT2 1.08574156066353 1.76407192348131e-11 -1.17471907439772 6.50761494287311e-25 MirTarget;miRNATAP -0.186527634714023 1.17564460119085e-07 NA NA NA hsa-miR-454-3p FERMT2 0.668749059573955 2.42670710515113e-06 -1.17471907439772 6.50761494287311e-25 miRNATAP -0.158084067592663 0.000115880774075841 NA NA NA hsa-miR-15b-3p FGF2 0.238105490431193 0.0997721500357416 -1.08625533231299 0.000324809942833161 mirMAP -0.499213807743807 9.41955107470528e-07 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.230566941413564 0.0824765001857479 -1.08625533231299 0.000324809942833161 MirTarget;miRNATAP -0.306809751282981 0.00622064491645458 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 -0.0336420826463706 0.805158952566973 -1.08625533231299 0.000324809942833161 mirMAP -0.422467965590387 0.000103679884556575 NA NA NA hsa-miR-181a-5p FGF2 0.250113435902954 0.0551933249319293 -1.08625533231299 0.000324809942833161 mirMAP -0.406045352280239 0.000358497143826792 NA NA NA hsa-miR-181b-5p FGF2 0.488256489401108 0.00105321129419701 -1.08625533231299 0.000324809942833161 mirMAP -0.523910277677257 9.1015168945214e-08 NA NA NA hsa-miR-19b-1-5p FGF2 -0.277804782598538 0.0783067794722916 -1.08625533231299 0.000324809942833161 mirMAP -0.529151998934904 1.16181517704286e-08 NA NA NA hsa-miR-200b-3p FGF2 -1.29335788099229 0.000268623234305059 -1.08625533231299 0.000324809942833161 mirMAP -0.168899172593471 4.11351056555817e-05 NA NA NA hsa-miR-200c-3p FGF2 -0.104675615392797 0.716957669484981 -1.08625533231299 0.000324809942833161 mirMAP -0.156084549253076 0.00233819769179705 NA NA NA hsa-miR-20a-3p FGF2 -0.318177901603857 0.0467885456739855 -1.08625533231299 0.000324809942833161 mirMAP -0.492065243098747 8.09310422865092e-08 NA NA NA hsa-miR-21-3p FGF2 -0.484219378716006 0.00299941098417659 -1.08625533231299 0.000324809942833161 mirMAP -0.240197113439825 0.00811114129230132 NA NA NA hsa-miR-21-5p FGF2 1.51084295924322 1.54551622173259e-34 -1.08625533231299 0.000324809942833161 mirMAP -0.443381765546842 5.91228766084995e-05 NA NA NA hsa-miR-217 FGF2 1.05797297540381 0.0401026692682422 -1.08625533231299 0.000324809942833161 miRanda -0.127490520581258 7.38698652450206e-06 NA NA NA hsa-miR-335-3p FGF2 -0.275199247483111 0.106629165248783 -1.08625533231299 0.000324809942833161 mirMAP -0.405107692314837 2.67658505476485e-06 NA NA NA hsa-miR-338-5p FGF2 -0.221898432884726 0.252390988727086 -1.08625533231299 0.000324809942833161 mirMAP -0.277477917380717 0.000298421894309671 NA NA NA hsa-miR-429 FGF2 -1.40262535827285 6.93982219171912e-05 -1.08625533231299 0.000324809942833161 mirMAP -0.192074793475977 4.45604159403906e-06 NA NA NA hsa-miR-452-5p FGF2 1.91544498799508 1.81995982853313e-14 -1.08625533231299 0.000324809942833161 mirMAP -0.254292038125162 7.84361502048493e-06 NA NA NA hsa-miR-589-3p FGF2 1.16846704028095 5.88525574424201e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.346323302130209 2.68946343007257e-05 NA NA NA hsa-miR-92a-3p FGF2 0.212391012518195 0.134292268089997 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.635934402042256 6.72536311164143e-10 NA NA NA hsa-miR-93-3p FGF2 0.402821129107592 0.00131324842735588 -1.08625533231299 0.000324809942833161 mirMAP -0.437085459323848 0.000209985380897254 NA NA NA hsa-miR-193b-3p FLNA -0.166697207281748 0.272022543069482 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.255056648016732 8.03407035240961e-06 NA NA NA hsa-miR-20a-5p FLNA 0.854326758727003 5.04256669663285e-07 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.238395501979443 1.97781492413483e-06 NA NA NA hsa-miR-23b-3p FLNA -0.530561587109023 5.43807206823652e-07 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.280105210478808 0.00059922753549396 24443580 Kaplan-Meier and multivariate analysis showed a significant association with tumour relapses for miR-23b and with tumour-specific death for miR-150 in PD and oPD thyroid carcinomas thyroid cancer hsa-miR-378a-3p FLNA -1.1920055906972 3.23538871733634e-10 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.197252838282232 9.82760832497973e-06 NA NA NA hsa-miR-92a-3p FLNA 0.212391012518195 0.134292268089997 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.313354262288746 2.67776037776007e-07 NA NA NA hsa-miR-28-5p FMOD -0.430964830599964 2.67367257252925e-06 -1.44418292650982 3.37377389948551e-06 miRanda -0.57475400329031 0.000567474727119651 NA NA NA hsa-miR-590-5p FMOD -0.103355559980404 0.310027295317092 -1.44418292650982 3.37377389948551e-06 miRanda -0.493345854203056 0.00116698653152509 NA NA NA hsa-miR-125a-3p FN1 -0.841683158494395 3.51202687176603e-05 -0.485556836875999 0.000166548369488467 miRanda -0.100307990153966 0.00143868392098275 NA NA NA hsa-miR-148a-5p FSTL1 -0.767626696027761 1.08359477494797e-06 -0.53295806881748 0.00292082806371731 mirMAP -0.31412274620126 6.85701583572212e-09 NA NA NA hsa-miR-20a-3p FSTL1 -0.318177901603857 0.0467885456739855 -0.53295806881748 0.00292082806371731 mirMAP -0.213602830285774 9.20312019962985e-05 NA NA NA hsa-miR-29a-5p FSTL1 -0.113555908626946 0.349622266470788 -0.53295806881748 0.00292082806371731 mirMAP -0.192292800345666 0.00815173987998559 NA NA NA hsa-miR-362-5p FSTL1 0.717921690799312 1.68392734504524e-05 -0.53295806881748 0.00292082806371731 mirMAP -0.145118935928883 0.00532899827432631 NA NA NA hsa-miR-374a-5p FSTL1 0.016390363747302 0.869784217438621 -0.53295806881748 0.00292082806371731 mirMAP -0.239101438953299 0.00701807099180635 NA NA NA hsa-miR-455-5p FSTL1 -0.270546034117157 0.0581320703577731 -0.53295806881748 0.00292082806371731 miRanda -0.299441858184359 8.81757042017881e-07 NA NA NA hsa-miR-548b-3p FSTL1 -0.0203576084717134 0.930819503166956 -0.53295806881748 0.00292082806371731 mirMAP -0.274674084364268 8.79455958575161e-14 NA NA NA hsa-miR-616-5p FSTL1 0.150569904638223 0.402836556304524 -0.53295806881748 0.00292082806371731 mirMAP -0.266921501651917 3.12182015394703e-08 NA NA NA hsa-miR-122-5p FSTL3 -1.23907441373955 4.42181244888642e-06 -0.0773472804803008 0.763187351732186 miRNAWalker2_validate -0.26074078671664 7.00580969748163e-09 NA NA NA hsa-miR-362-3p FZD8 0.814007335895913 2.00108618836568e-09 -1.21039879054975 2.52210905797718e-08 miRanda -0.247656870244882 0.00149588487455642 NA NA NA hsa-miR-374b-5p FZD8 -0.307538028546424 0.0030079617545972 -1.21039879054975 2.52210905797718e-08 miRNAWalker2_validate -0.276231840355344 0.0082320939699218 NA NA NA hsa-miR-148b-3p GADD45A 0.266862251671911 0.00185271302045935 -1.18438355981419 2.04421074395418e-12 MirTarget -0.53346134919236 5.63428920227987e-08 NA NA NA hsa-miR-301a-3p GADD45A 0.842910511640361 1.43446467417891e-06 -1.18438355981419 2.04421074395418e-12 MirTarget;miRNATAP -0.429003570363722 3.99121895415153e-21 NA NA NA hsa-miR-324-5p GADD45A 0.372933276649782 0.00592280066108904 -1.18438355981419 2.04421074395418e-12 miRanda -0.518772278708973 4.69587473312867e-18 NA NA NA hsa-miR-331-5p GADD45A 0.213759185384356 0.120772399478646 -1.18438355981419 2.04421074395418e-12 PITA;miRNATAP -0.430187189615618 9.35766561284238e-13 NA NA NA hsa-miR-421 GADD45A 0.941856334694081 6.12167297054077e-08 -1.18438355981419 2.04421074395418e-12 miRanda -0.399146316642953 4.95904028323981e-18 NA NA NA hsa-miR-429 GADD45A -1.40262535827285 6.93982219171912e-05 -1.18438355981419 2.04421074395418e-12 miRNATAP -0.147502825337448 3.86036414101022e-10 NA NA NA hsa-miR-454-3p GADD45A 0.668749059573955 2.42670710515113e-06 -1.18438355981419 2.04421074395418e-12 MirTarget;miRNATAP -0.336757743574097 6.70178941647605e-09 NA NA NA hsa-miR-500a-5p GADD45A 0.797906382969156 9.15958171084226e-08 -1.18438355981419 2.04421074395418e-12 MirTarget;miRNATAP -0.380400118148641 2.78037785058895e-12 NA NA NA hsa-miR-500b-5p GADD45A 0.79864276129988 8.80934488971056e-08 -1.18438355981419 2.04421074395418e-12 MirTarget -0.380385448906191 2.83925177775155e-12 NA NA NA hsa-miR-502-5p GADD45A 0.892373335336396 1.7122694518919e-06 -1.18438355981419 2.04421074395418e-12 MirTarget;PITA;miRNATAP -0.211861066175866 2.8783697640044e-06 NA NA NA hsa-miR-324-3p GADD45B 0.260348469146494 0.0506141704203545 -2.18315196507153 1.75545549044514e-24 MirTarget;miRNATAP -0.489337683262879 2.36967761576399e-09 NA NA NA hsa-miR-130b-3p GAS1 0.687190305027546 0.000109068658562255 -2.01123836877249 1.00269358999977e-12 miRNAWalker2_validate -0.385947454308948 8.52645522544854e-07 NA NA NA hsa-miR-148a-3p GAS1 -0.748702855596996 3.93313343865641e-07 -2.01123836877249 1.00269358999977e-12 miRNAWalker2_validate -0.446935540677881 1.98427341642504e-06 NA NA NA hsa-miR-186-5p GAS1 -0.060103391373687 0.535288717081205 -2.01123836877249 1.00269358999977e-12 mirMAP -0.399507082742327 0.00690046129120617 NA NA NA hsa-miR-32-3p GAS1 0.219109440121582 0.207217051619543 -2.01123836877249 1.00269358999977e-12 mirMAP -0.448405113095423 7.13372551606521e-08 NA NA NA hsa-miR-33a-5p GAS1 -0.767474460958522 1.09948756118522e-05 -2.01123836877249 1.00269358999977e-12 miRNATAP -0.231849793109903 0.00389641988964782 NA NA NA hsa-miR-34a-5p GAS1 1.03694231790865 5.74864019540594e-14 -2.01123836877249 1.00269358999977e-12 miRNAWalker2_validate;miRNATAP -0.40385806079271 4.64900181940774e-05 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-224-3p GEM 1.40770116795301 1.31426607144612e-08 -1.33419875801541 8.85114971471045e-07 MirTarget -0.142917036291866 0.00795564313541513 NA NA NA hsa-miR-361-5p GEM 0.233202959858696 0.00961572812255327 -1.33419875801541 8.85114971471045e-07 miRanda -0.704368407694241 2.35303017937697e-06 NA NA NA hsa-miR-148a-5p GJA1 -0.767626696027761 1.08359477494797e-06 0.506352390170207 0.00155115110748353 MirTarget;miRNATAP -0.202529950380846 3.47863671567994e-05 NA NA NA hsa-miR-17-5p GJA1 0.698861147045461 2.43854106455398e-05 0.506352390170207 0.00155115110748353 TargetScan -0.156683389793051 0.000818678717928076 NA NA NA hsa-miR-193a-3p GJA1 -0.117675551589896 0.309391958208578 0.506352390170207 0.00155115110748353 miRanda -0.234001960168866 0.000577161990141332 NA NA NA hsa-miR-19a-3p GJA1 1.01712596153672 2.57753201450625e-07 0.506352390170207 0.00155115110748353 MirTarget;miRNATAP -0.109674196237453 0.00502056176617026 NA NA NA hsa-miR-19b-3p GJA1 0.601279551368824 0.00016685097085251 0.506352390170207 0.00155115110748353 MirTarget;miRNATAP -0.150005836493063 0.00207536126151614 NA NA NA hsa-miR-33a-3p GJA1 -0.683025859637737 1.01106097756419e-05 0.506352390170207 0.00155115110748353 MirTarget;miRNATAP -0.193768371233115 0.000108279957109494 NA NA NA hsa-miR-455-5p GJA1 -0.270546034117157 0.0581320703577731 0.506352390170207 0.00155115110748353 miRanda -0.208190142876 0.000143167014644293 NA NA NA hsa-miR-616-5p GJA1 0.150569904638223 0.402836556304524 0.506352390170207 0.00155115110748353 MirTarget;mirMAP -0.166557463973006 0.000129363292708832 NA NA NA hsa-miR-624-5p GJA1 -0.639533773668123 6.79146620944254e-06 0.506352390170207 0.00155115110748353 MirTarget -0.213711983840535 8.64005682374339e-05 NA NA NA hsa-miR-107 GLIPR1 0.241662461253461 0.0170788899505389 -0.210856741137956 0.266406837563875 miRanda -0.463853355681386 3.37107395516425e-07 NA NA NA hsa-miR-19a-3p GLIPR1 1.01712596153672 2.57753201450625e-07 -0.210856741137956 0.266406837563875 mirMAP -0.154603903064506 0.000784680849903863 NA NA NA hsa-miR-19b-3p GLIPR1 0.601279551368824 0.00016685097085251 -0.210856741137956 0.266406837563875 mirMAP -0.216604798024406 0.000157872510109536 NA NA NA hsa-miR-20a-3p GLIPR1 -0.318177901603857 0.0467885456739855 -0.210856741137956 0.266406837563875 mirMAP -0.247682647476749 1.64928233774876e-05 NA NA NA hsa-miR-23b-3p GLIPR1 -0.530561587109023 5.43807206823652e-07 -0.210856741137956 0.266406837563875 mirMAP -0.391219187136706 5.61556781918622e-06 NA NA NA hsa-miR-28-5p GLIPR1 -0.430964830599964 2.67367257252925e-06 -0.210856741137956 0.266406837563875 miRanda -0.290528518539134 0.00391917546320843 NA NA NA hsa-miR-30d-3p GLIPR1 -0.120562286038759 0.329549534782125 -0.210856741137956 0.266406837563875 mirMAP -0.296523706568671 7.44336546785997e-05 NA NA NA hsa-miR-361-5p GLIPR1 0.233202959858696 0.00961572812255327 -0.210856741137956 0.266406837563875 MirTarget;miRanda;mirMAP -0.286257849699746 0.00579115587159426 NA NA NA hsa-miR-194-3p GPC1 -0.772747277805343 2.9537465170191e-05 -0.83822595271141 0.000814546458738611 mirMAP -0.238360992313965 0.000277201417667481 NA NA NA hsa-miR-324-3p GPC1 0.260348469146494 0.0506141704203545 -0.83822595271141 0.000814546458738611 MirTarget -0.290695709344148 0.00164234651474182 NA NA NA hsa-miR-29a-3p GPX7 -0.856762511178136 4.65330336378459e-12 0.242748278541907 0.324017600889457 MirTarget;miRNATAP -0.61112756617649 4.37229640292111e-11 NA NA NA hsa-miR-29b-3p GPX7 -0.348885528720517 0.0121441341291285 0.242748278541907 0.324017600889457 MirTarget;miRNATAP -0.382876097215499 7.85711137600111e-06 NA NA NA hsa-miR-29c-3p GPX7 -1.4367517608807 1.61767774905781e-21 0.242748278541907 0.324017600889457 MirTarget;miRNATAP -0.362312577479615 1.34431746414644e-06 NA NA NA hsa-miR-107 GREM1 0.241662461253461 0.0170788899505389 -0.0577956254982771 0.888064615887716 miRanda -0.854723431819905 1.5316686648382e-05 NA NA NA hsa-miR-10b-3p GREM1 2.77189254628215 2.26687582932628e-20 -0.0577956254982771 0.888064615887716 MirTarget -0.215824065622198 0.00163399492159191 NA NA NA hsa-miR-128-3p GREM1 0.289735108018712 0.0114419474207889 -0.0577956254982771 0.888064615887716 MirTarget -0.504018241626626 0.00404070396081527 NA NA NA hsa-miR-151a-3p GREM1 0.330888909161891 0.00418075524865448 -0.0577956254982771 0.888064615887716 MirTarget -0.525786556191921 0.00244823384399516 NA NA NA hsa-miR-32-3p GREM1 0.219109440121582 0.207217051619543 -0.0577956254982771 0.888064615887716 mirMAP -0.430866582998594 0.000283830189722321 NA NA NA hsa-miR-616-5p GREM1 0.150569904638223 0.402836556304524 -0.0577956254982771 0.888064615887716 mirMAP -0.410445332393911 0.000223968553122472 NA NA NA hsa-miR-16-5p HTRA1 -0.398577235179603 0.000101598495180191 -0.274585348063549 0.176067930311405 miRNAWalker2_validate -0.276008949445503 0.00427222093353426 NA NA NA hsa-miR-26b-5p HTRA1 -1.10804856399744 4.14176110314282e-22 -0.274585348063549 0.176067930311405 miRNAWalker2_validate -0.224353071617962 0.00642829337784544 NA NA NA hsa-miR-103a-3p ID2 0.765568928457606 3.05497476509383e-12 -1.61066414419896 4.81945990305561e-27 miRNAWalker2_validate;miRTarBase -0.312121729027969 6.10447032095761e-06 NA NA NA hsa-miR-125a-5p IGFBP2 -0.91219969372382 1.38256246489548e-07 -1.29897696905174 0.000104402278916375 miRanda -0.270788500817207 0.00382918389836109 NA NA NA hsa-miR-330-5p IGFBP2 0.442231058604099 0.0053308560843808 -1.29897696905174 0.000104402278916375 miRanda -0.415246182138627 5.53407561701831e-05 NA NA NA hsa-miR-224-5p IGFBP3 2.67175249172213 1.46995328399796e-18 -2.55803658929415 1.7955269745611e-33 MirTarget -0.174025915145798 6.44207387905941e-07 NA NA NA hsa-miR-34a-5p IGFBP3 1.03694231790865 5.74864019540594e-14 -2.55803658929415 1.7955269745611e-33 miRNATAP -0.464959768400917 2.32405323398958e-09 NA NA NA hsa-miR-330-5p IGFBP4 0.442231058604099 0.0053308560843808 -1.26913520728898 1.75759506745055e-17 MirTarget;miRanda -0.229494422792611 1.15541942095525e-06 NA NA NA hsa-miR-107 IL15 0.241662461253461 0.0170788899505389 -0.299033597604689 0.133566104518099 miRanda;miRNATAP -0.558377313339206 4.35121973873231e-09 NA NA NA hsa-miR-148a-3p IL15 -0.748702855596996 3.93313343865641e-07 -0.299033597604689 0.133566104518099 MirTarget -0.360950562564519 1.84990625247238e-08 NA NA NA hsa-miR-192-5p IL15 -0.50188499512787 0.00344713341196035 -0.299033597604689 0.133566104518099 miRNAWalker2_validate -0.307919878200709 3.2482224824806e-08 NA NA NA hsa-miR-19a-3p IL15 1.01712596153672 2.57753201450625e-07 -0.299033597604689 0.133566104518099 MirTarget -0.169187617208509 0.000469880891066932 NA NA NA hsa-miR-19b-3p IL15 0.601279551368824 0.00016685097085251 -0.299033597604689 0.133566104518099 MirTarget -0.248280940020467 3.69036895748539e-05 NA NA NA hsa-miR-107 IL6 0.241662461253461 0.0170788899505389 -2.0069298945737 2.33900822782796e-09 miRanda -0.962941107019514 4.00052775475113e-09 NA NA NA hsa-miR-361-5p IL6 0.233202959858696 0.00961572812255327 -2.0069298945737 2.33900822782796e-09 miRanda -0.746870831233242 6.34041923472147e-05 NA NA NA hsa-miR-365a-3p IL6 0.164591326307714 0.15325084963213 -2.0069298945737 2.33900822782796e-09 miRNAWalker2_validate -0.508496672954192 0.000482261146415095 NA NA NA hsa-miR-148b-3p INHBA 0.266862251671911 0.00185271302045935 -1.24139262923259 1.82491752448182e-06 miRNAWalker2_validate -0.4775304543089 0.00158928464481298 NA NA NA hsa-miR-30d-5p INHBA 0.718283816348023 2.47422074061352e-08 -1.24139262923259 1.82491752448182e-06 mirMAP -0.475857712731218 1.05402445581133e-06 NA NA NA hsa-miR-107 ITGA2 0.241662461253461 0.0170788899505389 1.53120134028147 5.03620431516659e-09 MirTarget;miRanda;miRNATAP -0.595579423085955 3.51813821910157e-06 NA NA NA hsa-miR-130a-3p ITGA2 -1.53229181736223 2.91460363624872e-19 1.53120134028147 5.03620431516659e-09 mirMAP -0.21817609840205 0.00273093457553046 NA NA NA hsa-miR-130b-3p ITGA2 0.687190305027546 0.000109068658562255 1.53120134028147 5.03620431516659e-09 mirMAP -0.238929988104481 0.00100816862732008 NA NA NA hsa-miR-139-5p ITGA2 -2.11299531796557 8.16407076415038e-28 1.53120134028147 5.03620431516659e-09 PITA;miRanda -0.348713430392277 1.86833411063269e-08 NA NA NA hsa-miR-195-5p ITGA2 -1.85907534356434 1.47434041676402e-22 1.53120134028147 5.03620431516659e-09 MirTarget;miRNATAP -0.186383881971086 0.00401127379239066 NA NA NA hsa-miR-19a-3p ITGA2 1.01712596153672 2.57753201450625e-07 1.53120134028147 5.03620431516659e-09 MirTarget -0.232452076582239 0.000333020536473977 NA NA NA hsa-miR-19b-3p ITGA2 0.601279551368824 0.00016685097085251 1.53120134028147 5.03620431516659e-09 MirTarget -0.34350775357453 2.00709629618829e-05 NA NA NA hsa-miR-26b-5p ITGA2 -1.10804856399744 4.14176110314282e-22 1.53120134028147 5.03620431516659e-09 mirMAP -0.455075493018862 2.37547429819346e-05 NA NA NA hsa-miR-27b-3p ITGA2 -0.823491817819754 9.20935302746823e-14 1.53120134028147 5.03620431516659e-09 miRNATAP -0.648959489127879 1.00730961424074e-08 NA NA NA hsa-miR-30c-5p ITGA2 -0.432111642767632 0.000159764714931007 1.53120134028147 5.03620431516659e-09 mirMAP -0.374655382724916 0.000961645145926353 NA NA NA hsa-miR-30e-5p ITGA2 -0.627815042856657 3.02205690184908e-10 1.53120134028147 5.03620431516659e-09 mirMAP -0.737206572787374 6.45205020884361e-09 NA NA NA hsa-miR-326 ITGA2 -1.881935132554 1.68087316863775e-21 1.53120134028147 5.03620431516659e-09 PITA -0.189087919083097 0.00273542798727671 NA NA NA hsa-miR-33a-3p ITGA2 -0.683025859637737 1.01106097756419e-05 1.53120134028147 5.03620431516659e-09 mirMAP -0.480065029116681 5.3570039903457e-09 NA NA NA hsa-miR-3607-3p ITGA2 -2.15518588554493 1.03390728226728e-23 1.53120134028147 5.03620431516659e-09 mirMAP -0.173252523084354 0.0024333016929685 NA NA NA hsa-miR-497-5p ITGA2 -1.41371173021948 7.09278946477743e-17 1.53120134028147 5.03620431516659e-09 MirTarget;miRNATAP -0.293526481317459 6.61553414485539e-05 NA NA NA hsa-miR-148a-3p ITGA5 -0.748702855596996 3.93313343865641e-07 0.471634888877482 5.29697754708897e-05 miRNATAP -0.307894492928595 8.35158872292536e-17 NA NA NA hsa-miR-32-5p ITGA5 0.0806126674664016 0.548984992497432 0.471634888877482 5.29697754708897e-05 miRNATAP -0.211172885193471 6.1421768497938e-07 NA NA NA hsa-miR-192-5p ITGAV -0.50188499512787 0.00344713341196035 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget -0.344370980466671 1.89013250176103e-15 NA NA NA hsa-miR-32-5p ITGAV 0.0806126674664016 0.548984992497432 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget;miRNATAP -0.274975166498264 1.42681810268729e-06 NA NA NA hsa-miR-33a-3p ITGAV -0.683025859637737 1.01106097756419e-05 0.42083458357731 0.00760476174317356 MirTarget -0.155984185219414 0.00158654023964867 NA NA NA hsa-miR-92a-3p ITGAV 0.212391012518195 0.134292268089997 0.42083458357731 0.00760476174317356 MirTarget;miRNATAP -0.257814482101981 1.80305424957411e-06 NA NA NA hsa-miR-140-3p ITGB1 0.546012239205329 4.84578261098777e-11 0.150635638369529 0.0875061080940868 PITA -0.175902840174304 0.000564338708599815 NA NA NA hsa-miR-192-5p ITGB1 -0.50188499512787 0.00344713341196035 0.150635638369529 0.0875061080940868 miRNAWalker2_validate -0.159167916481672 6.60024481999039e-11 NA NA NA hsa-miR-590-5p ITGB1 -0.103355559980404 0.310027295317092 0.150635638369529 0.0875061080940868 miRanda -0.136906492054453 0.00125518477546468 NA NA NA hsa-miR-146b-5p ITGB3 0.419719546795449 0.0457375823220155 -0.984722780911358 0.000225186373225592 miRanda -0.209405714984689 0.000753494487303087 NA NA NA hsa-miR-221-3p ITGB3 1.12244756358612 3.48370308238012e-13 -0.984722780911358 0.000225186373225592 MirTarget -0.386235530184791 2.395985878903e-06 NA NA NA hsa-miR-222-3p ITGB3 1.08574156066353 1.76407192348131e-11 -0.984722780911358 0.000225186373225592 MirTarget -0.292691325646809 0.000210297407328954 NA NA NA hsa-miR-30b-5p ITGB3 -0.54056186708617 2.44688760798341e-05 -0.984722780911358 0.000225186373225592 mirMAP -0.338348015277282 0.000871538256799819 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-30d-5p ITGB3 0.718283816348023 2.47422074061352e-08 -0.984722780911358 0.000225186373225592 miRNATAP -0.536944941610996 6.146536518821e-08 NA NA NA hsa-miR-338-3p ITGB3 0.543135607704581 0.00461167747143826 -0.984722780911358 0.000225186373225592 miRanda -0.215934453214511 0.0015046418079117 27431198 Furthermore we also identified a metastasis related protein integrin β3 ITGB3 as a novel target gene of miR-338 metastasis lung cancer hsa-miR-429 ITGB3 -1.40262535827285 6.93982219171912e-05 -0.984722780911358 0.000225186373225592 miRanda -0.108897560094347 0.00347304092504122 NA NA NA hsa-miR-378a-5p ITGB5 -1.58667444700188 3.19640857320504e-17 0.292212681922662 0.00246071719815647 MirTarget -0.121968371154877 2.94684418151273e-07 NA NA NA hsa-miR-486-5p ITGB5 -1.77766890600022 2.9071717929922e-14 0.292212681922662 0.00246071719815647 miRanda -0.117509353238263 8.00849793913438e-10 NA NA NA hsa-miR-501-5p JUN 1.15231083477882 2.98906150004088e-10 -1.59869078760734 2.2999762521731e-23 MirTarget;PITA;miRNATAP -0.201525326742419 4.62918338980132e-06 NA NA NA hsa-miR-92a-3p JUN 0.212391012518195 0.134292268089997 -1.59869078760734 2.2999762521731e-23 miRNATAP -0.217656471355875 0.000190729748454868 NA NA NA hsa-miR-93-5p JUN 1.39518349670953 2.84167728726712e-25 -1.59869078760734 2.2999762521731e-23 miRNAWalker2_validate -0.346015058492204 1.41571654493278e-09 NA NA NA hsa-miR-125a-3p LAMA3 -0.841683158494395 3.51202687176603e-05 1.44669397870991 3.68334239314585e-06 miRanda -0.23032131162349 0.00271226730803684 NA NA NA hsa-miR-17-5p LAMA3 0.698861147045461 2.43854106455398e-05 1.44669397870991 3.68334239314585e-06 TargetScan -0.48787800614806 8.9429862836022e-08 NA NA NA hsa-miR-181a-5p LAMA3 0.250113435902954 0.0551933249319293 1.44669397870991 3.68334239314585e-06 miRNAWalker2_validate -0.480393838339496 4.68441145042477e-05 NA NA NA hsa-miR-217 LAMA3 1.05797297540381 0.0401026692682422 1.44669397870991 3.68334239314585e-06 PITA;miRanda -0.141216744729264 1.72158329960106e-06 NA NA NA hsa-miR-122-5p LAMC1 -1.23907441373955 4.42181244888642e-06 1.18164580989765 3.65525462453826e-17 MirTarget;miRNATAP -0.212671515224247 2.05957517770403e-17 NA NA NA hsa-miR-139-5p LAMC1 -2.11299531796557 8.16407076415038e-28 1.18164580989765 3.65525462453826e-17 miRanda -0.226258385144221 1.69064747798937e-11 NA NA NA hsa-miR-193a-3p LAMC1 -0.117675551589896 0.309391958208578 1.18164580989765 3.65525462453826e-17 MirTarget;PITA;miRanda -0.197168799954626 0.00142654058419805 NA NA NA hsa-miR-193b-3p LAMC1 -0.166697207281748 0.272022543069482 1.18164580989765 3.65525462453826e-17 MirTarget -0.230227935704299 7.58927130756756e-07 NA NA NA hsa-miR-195-5p LAMC1 -1.85907534356434 1.47434041676402e-22 1.18164580989765 3.65525462453826e-17 MirTarget -0.160738646500811 4.77301456025353e-06 NA NA NA hsa-miR-22-3p LAMC1 -0.628561621952407 1.33755558015523e-09 1.18164580989765 3.65525462453826e-17 MirTarget;miRNATAP -0.444929117565246 2.00326518461981e-11 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29a-3p LAMC1 -0.856762511178136 4.65330336378459e-12 1.18164580989765 3.65525462453826e-17 MirTarget;miRNATAP -0.293512586709957 1.24062705212149e-07 26052614 The identification of laminin gamma 1 LAMC1 and myeloid cell leukemia 1 MCL1 as direct targets of miR-22 and miR-29a respectively suggested a tumor-suppressive role of these miRNAs prostate cancer hsa-miR-29c-3p LAMC1 -1.4367517608807 1.61767774905781e-21 1.18164580989765 3.65525462453826e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.247557685092554 2.2318434063202e-08 NA NA NA hsa-miR-33a-3p LAMC1 -0.683025859637737 1.01106097756419e-05 1.18164580989765 3.65525462453826e-17 mirMAP -0.127691716393828 0.00517308713713168 NA NA NA hsa-miR-424-5p LAMC1 -2.62653257498508 2.38997974737991e-50 1.18164580989765 3.65525462453826e-17 MirTarget;miRNATAP -0.164700621655061 3.21163281537882e-06 NA NA NA hsa-miR-497-5p LAMC1 -1.41371173021948 7.09278946477743e-17 1.18164580989765 3.65525462453826e-17 MirTarget;miRNATAP -0.158099601835923 8.46733346137645e-05 NA NA NA hsa-miR-548b-3p LAMC1 -0.0203576084717134 0.930819503166956 1.18164580989765 3.65525462453826e-17 PITA -0.101818565132175 0.000912887751443203 NA NA NA hsa-miR-7-1-3p LAMC1 -0.569105143287799 1.85297665041424e-05 1.18164580989765 3.65525462453826e-17 mirMAP -0.165571379361951 0.00184705996977273 NA NA NA hsa-miR-148b-3p LAMC2 0.266862251671911 0.00185271302045935 -1.88411646680975 6.65805574231518e-06 miRNAWalker2_validate -0.825518499166096 0.000668242286477737 NA NA NA hsa-miR-193b-3p LAMC2 -0.166697207281748 0.272022543069482 -1.88411646680975 6.65805574231518e-06 MirTarget;miRNATAP -0.688371243499296 3.2964291900371e-07 NA NA NA hsa-miR-548b-3p LAMC2 -0.0203576084717134 0.930819503166956 -1.88411646680975 6.65805574231518e-06 miRNATAP -0.727182288278947 2.50684183944719e-17 NA NA NA hsa-miR-660-5p LAMC2 0.989755850734071 5.69930767464937e-14 -1.88411646680975 6.65805574231518e-06 MirTarget -0.743765339410472 8.10222595132239e-07 NA NA NA hsa-miR-107 LOX 0.241662461253461 0.0170788899505389 1.12460456664183 4.86114109294809e-06 miRanda -0.359811707925825 0.002845125220198 NA NA NA hsa-miR-27b-3p LOX -0.823491817819754 9.20935302746823e-14 1.12460456664183 4.86114109294809e-06 miRNATAP -0.30480513226165 0.0044372476136409 NA NA NA hsa-miR-30d-5p LOX 0.718283816348023 2.47422074061352e-08 1.12460456664183 4.86114109294809e-06 miRNATAP -0.363631327830074 8.53778865460247e-05 NA NA NA hsa-miR-455-3p LOX -1.3998033821095 5.72010709806871e-17 1.12460456664183 4.86114109294809e-06 PITA;miRNATAP -0.18750511581047 0.00723327461313756 NA NA NA hsa-miR-193b-3p LOXL1 -0.166697207281748 0.272022543069482 0.294842676716659 0.335995677460625 miRNAWalker2_validate -0.459114880187752 2.71448739383965e-06 NA NA NA hsa-miR-192-5p LOXL2 -0.50188499512787 0.00344713341196035 1.63969538101948 3.81782645914369e-28 miRNAWalker2_validate -0.406183915121298 4.54599624471813e-21 NA NA NA hsa-miR-28-5p LOXL2 -0.430964830599964 2.67367257252925e-06 1.63969538101948 3.81782645914369e-28 miRanda -0.414203048273971 8.20137540975636e-07 NA NA NA hsa-miR-338-5p LRP1 -0.221898432884726 0.252390988727086 -0.596071615882487 1.4712774095994e-06 miRNAWalker2_validate;MirTarget;PITA;miRNATAP -0.10977522299328 0.00050828610056536 NA NA NA hsa-miR-339-5p LRP1 0.280589919878422 0.0355660282647215 -0.596071615882487 1.4712774095994e-06 miRanda -0.142434054379196 0.0018616171656132 NA NA NA hsa-miR-429 LRP1 -1.40262535827285 6.93982219171912e-05 -0.596071615882487 1.4712774095994e-06 PITA;miRanda;miRNATAP -0.102624421351401 1.80727381991249e-09 NA NA NA hsa-miR-107 LRRC15 0.241662461253461 0.0170788899505389 -0.934213828577622 0.00924441278375808 PITA -0.821186125443722 2.08693409705278e-06 NA NA NA hsa-miR-17-3p LRRC15 0.410352776142368 0.00422200500748636 -0.934213828577622 0.00924441278375808 mirMAP -0.449246926254015 0.00022852366492109 NA NA NA hsa-miR-30d-5p LRRC15 0.718283816348023 2.47422074061352e-08 -0.934213828577622 0.00924441278375808 mirMAP -0.451170841738486 0.000778266262198124 NA NA NA hsa-miR-374a-5p LRRC15 0.016390363747302 0.869784217438621 -0.934213828577622 0.00924441278375808 mirMAP -0.561333099081479 0.00155347273429375 NA NA NA hsa-miR-374b-5p LRRC15 -0.307538028546424 0.0030079617545972 -0.934213828577622 0.00924441278375808 mirMAP -0.492107586951529 0.00383368238273063 NA NA NA hsa-miR-590-5p LUM -0.103355559980404 0.310027295317092 -2.32389098446654 7.66980769372537e-07 MirTarget;PITA;miRanda -0.805340588358493 0.000463156865551858 NA NA NA hsa-miR-30d-3p MAGEE1 -0.120562286038759 0.329549534782125 0.519775641894942 0.0137579687436851 MirTarget -0.244409121081941 0.00356038118251281 NA NA NA hsa-miR-21-5p MATN2 1.51084295924322 1.54551622173259e-34 -0.692218006755673 0.0026937518103409 miRNATAP -0.439006230822363 1.45013185590069e-07 NA NA NA hsa-miR-148a-3p MATN3 -0.748702855596996 3.93313343865641e-07 2.24574154450948 1.20068691324261e-08 MirTarget -0.571507102978337 1.13120648716878e-05 NA NA NA hsa-miR-152-3p MATN3 -0.959123731390966 3.24700662487287e-10 2.24574154450948 1.20068691324261e-08 MirTarget -0.418656408523074 0.000848105936591093 NA NA NA hsa-miR-26b-5p MATN3 -1.10804856399744 4.14176110314282e-22 2.24574154450948 1.20068691324261e-08 miRNAWalker2_validate -0.585921327282714 0.000306925341013339 NA NA NA hsa-miR-27b-3p MATN3 -0.823491817819754 9.20935302746823e-14 2.24574154450948 1.20068691324261e-08 MirTarget;miRNATAP -0.87816733952884 2.77796099819256e-07 NA NA NA hsa-let-7b-5p MCM7 -0.959013717270803 5.95127281258643e-11 1.28544451959494 2.38346141988918e-22 miRNAWalker2_validate -0.247616423212068 3.20929332495545e-08 NA NA NA hsa-miR-29a-3p MEST -0.856762511178136 4.65330336378459e-12 -0.745223908511012 6.12641025738862e-06 MirTarget;miRNATAP -0.31677561215913 5.96423519944164e-07 NA NA NA hsa-miR-29b-3p MEST -0.348885528720517 0.0121441341291285 -0.745223908511012 6.12641025738862e-06 MirTarget;miRNATAP -0.36772447814971 1.34614077363992e-10 NA NA NA hsa-miR-29c-3p MEST -1.4367517608807 1.61767774905781e-21 -0.745223908511012 6.12641025738862e-06 MirTarget;miRNATAP -0.262535551165514 2.16073906123927e-07 NA NA NA hsa-miR-664a-3p MEST 0.485807855553031 0.000732553249798598 -0.745223908511012 6.12641025738862e-06 MirTarget -0.151230801928077 0.0072350136421591 NA NA NA hsa-miR-26b-5p MMP14 -1.10804856399744 4.14176110314282e-22 0.86297207076826 2.15889003478401e-07 miRNATAP -0.35038785988309 2.28391892232755e-07 NA NA NA hsa-miR-374a-5p MMP14 0.016390363747302 0.869784217438621 0.86297207076826 2.15889003478401e-07 MirTarget -0.240648568695873 0.00383958590749487 NA NA NA hsa-miR-374b-5p MMP14 -0.307538028546424 0.0030079617545972 0.86297207076826 2.15889003478401e-07 MirTarget -0.298872915860838 0.000170612622833702 NA NA NA hsa-miR-17-5p MMP2 0.698861147045461 2.43854106455398e-05 -0.367677295764837 0.175296194273512 miRNAWalker2_validate;TargetScan -0.2392094481838 0.00251738988377827 NA NA NA hsa-miR-17-5p MMP3 0.698861147045461 2.43854106455398e-05 0.206938536377007 0.549747904802987 MirTarget -0.279850423645993 0.00559019017473018 NA NA NA hsa-miR-20a-5p MMP3 0.854326758727003 5.04256669663285e-07 0.206938536377007 0.549747904802987 MirTarget -0.30137535401111 0.00205862590490503 NA NA NA hsa-miR-101-3p MSX1 -1.48176407980989 3.98950707385704e-31 1.64867861143844 2.50604676499963e-18 miRNATAP -0.45990578914333 1.83149066128459e-11 NA NA NA hsa-miR-139-5p MSX1 -2.11299531796557 8.16407076415038e-28 1.64867861143844 2.50604676499963e-18 miRanda -0.194092736824484 2.62610238570598e-05 NA NA NA hsa-miR-144-3p MSX1 -2.97536914478815 6.00546047309683e-28 1.64867861143844 2.50604676499963e-18 miRNATAP -0.101183984244234 0.00214915853780227 NA NA NA hsa-miR-195-5p MSX1 -1.85907534356434 1.47434041676402e-22 1.64867861143844 2.50604676499963e-18 mirMAP -0.150955236287069 0.00158401840159246 NA NA NA hsa-miR-590-3p MSX1 -0.473167498047808 1.76652934637227e-05 1.64867861143844 2.50604676499963e-18 miRanda -0.257585671244225 0.00306120625174764 NA NA NA hsa-miR-185-5p MXRA5 0.480006257154717 6.35758891340152e-07 -2.19599102140454 4.19471601232711e-15 MirTarget -0.441280352951726 0.00253104316599192 NA NA NA hsa-miR-30d-5p MXRA5 0.718283816348023 2.47422074061352e-08 -2.19599102140454 4.19471601232711e-15 miRNATAP -0.462368898989493 1.73522349715223e-05 NA NA NA hsa-miR-146b-5p MYLK 0.419719546795449 0.0457375823220155 -1.14236369623552 6.9999057137519e-11 miRanda -0.158511280553425 0.00012794381552573 NA NA NA hsa-miR-15a-5p MYLK 0.349521211668244 0.000770735998804736 -1.14236369623552 6.9999057137519e-11 MirTarget;miRNATAP -0.224315263940168 0.00792609402220537 NA NA NA hsa-miR-16-2-3p MYLK -0.0336420826463706 0.805158952566973 -1.14236369623552 6.9999057137519e-11 mirMAP -0.201324004413116 0.00176008809560785 NA NA NA hsa-miR-193a-3p MYLK -0.117675551589896 0.309391958208578 -1.14236369623552 6.9999057137519e-11 miRanda -0.197550758437301 0.00947075457329433 NA NA NA hsa-miR-299-5p MYLK -1.29140172063665 7.07032129116092e-07 -1.14236369623552 6.9999057137519e-11 MirTarget -0.106098567788747 0.0017002149890485 NA NA NA hsa-miR-32-3p MYLK 0.219109440121582 0.207217051619543 -1.14236369623552 6.9999057137519e-11 mirMAP -0.159393825110509 0.00217763438366228 NA NA NA hsa-miR-335-3p MYLK -0.275199247483111 0.106629165248783 -1.14236369623552 6.9999057137519e-11 mirMAP -0.201500188028703 7.96666204461032e-05 NA NA NA hsa-miR-338-5p MYLK -0.221898432884726 0.252390988727086 -1.14236369623552 6.9999057137519e-11 mirMAP -0.122335772212223 0.00703051069139257 NA NA NA hsa-miR-362-5p MYLK 0.717921690799312 1.68392734504524e-05 -1.14236369623552 6.9999057137519e-11 TargetScan;miRNATAP -0.162512568364391 0.0017431619361719 NA NA NA hsa-miR-3682-3p MYLK 0.805600143458555 8.7874424633131e-06 -1.14236369623552 6.9999057137519e-11 mirMAP -0.20131913730827 4.88820452911043e-05 NA NA NA hsa-miR-409-3p MYLK -0.499649792570937 0.0526751181520117 -1.14236369623552 6.9999057137519e-11 MirTarget;PITA -0.147159859350932 1.18335044196222e-05 NA NA NA hsa-miR-495-3p MYLK -0.751193061269953 0.00388779118736635 -1.14236369623552 6.9999057137519e-11 MirTarget;mirMAP -0.113735122764354 0.000672013570409945 NA NA NA hsa-miR-501-5p MYLK 1.15231083477882 2.98906150004088e-10 -1.14236369623552 6.9999057137519e-11 MirTarget;PITA;miRNATAP -0.376302752200839 7.8598851831693e-17 NA NA NA hsa-miR-589-3p MYLK 1.16846704028095 5.88525574424201e-11 -1.14236369623552 6.9999057137519e-11 mirMAP -0.290430166079834 1.54712621186886e-09 NA NA NA hsa-miR-590-5p MYLK -0.103355559980404 0.310027295317092 -1.14236369623552 6.9999057137519e-11 miRanda -0.399562010832064 3.45225392569503e-06 NA NA NA hsa-miR-9-5p MYLK 1.26407994492898 8.53156156439881e-05 -1.14236369623552 6.9999057137519e-11 miRNAWalker2_validate -0.103848769294025 0.000105778380826521 NA NA NA hsa-miR-146b-5p NID2 0.419719546795449 0.0457375823220155 -0.0802964384348819 0.635707085737926 miRanda -0.149753150145886 0.000125254193140163 NA NA NA hsa-miR-30d-5p NID2 0.718283816348023 2.47422074061352e-08 -0.0802964384348819 0.635707085737926 miRNATAP -0.176061091484893 0.00536166226794464 NA NA NA hsa-miR-361-5p NID2 0.233202959858696 0.00961572812255327 -0.0802964384348819 0.635707085737926 miRanda -0.250234298512476 0.00689843807459786 NA NA NA hsa-miR-590-5p NID2 -0.103355559980404 0.310027295317092 -0.0802964384348819 0.635707085737926 miRanda -0.227325313720237 0.00550128486732477 NA NA NA hsa-miR-103a-3p NOTCH2 0.765568928457606 3.05497476509383e-12 -0.382079512558875 0.00411077346024402 MirTarget -0.200140216686413 0.000554161926768542 NA NA NA hsa-miR-107 NOTCH2 0.241662461253461 0.0170788899505389 -0.382079512558875 0.00411077346024402 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.212584678659513 0.000997936326855663 NA NA NA hsa-miR-146b-5p NOTCH2 0.419719546795449 0.0457375823220155 -0.382079512558875 0.00411077346024402 miRanda -0.13767547742131 7.26853497786302e-06 NA NA NA hsa-miR-148a-5p NOTCH2 -0.767626696027761 1.08359477494797e-06 -0.382079512558875 0.00411077346024402 MirTarget -0.124169741301974 0.0023627624116557 NA NA NA hsa-miR-15a-5p NOTCH2 0.349521211668244 0.000770735998804736 -0.382079512558875 0.00411077346024402 MirTarget -0.211011609000242 0.000764396919128515 NA NA NA hsa-miR-16-1-3p NOTCH2 0.392360028038559 0.00112481918108198 -0.382079512558875 0.00411077346024402 mirMAP -0.165851721677464 0.00213283435133142 NA NA NA hsa-miR-17-5p NOTCH2 0.698861147045461 2.43854106455398e-05 -0.382079512558875 0.00411077346024402 miRNAWalker2_validate -0.105084570695141 0.00703883528774371 NA NA NA hsa-miR-29b-3p NOTCH2 -0.348885528720517 0.0121441341291285 -0.382079512558875 0.00411077346024402 MirTarget -0.174961937874285 0.000176008140506499 NA NA NA hsa-miR-34a-5p NOTCH2 1.03694231790865 5.74864019540594e-14 -0.382079512558875 0.00411077346024402 miRNAWalker2_validate;miRNATAP -0.209801751186156 3.89799565892934e-06 NA NA NA hsa-miR-374a-5p NOTCH2 0.016390363747302 0.869784217438621 -0.382079512558875 0.00411077346024402 mirMAP -0.17868161171818 0.00665715296333492 NA NA NA hsa-miR-22-5p NT5E -0.630365901263172 3.32415348030414e-05 -1.22090773788306 8.8702357666604e-10 mirMAP -0.294612826694362 4.68145602617531e-06 NA NA NA hsa-miR-30a-5p NT5E -0.626257932887855 0.000108198196973765 -1.22090773788306 8.8702357666604e-10 miRNAWalker2_validate;miRNATAP -0.225081531964853 0.000209778106877177 NA NA NA hsa-miR-34a-5p NT5E 1.03694231790865 5.74864019540594e-14 -1.22090773788306 8.8702357666604e-10 miRNAWalker2_validate -0.192356981917961 0.00587873964838024 NA NA NA hsa-miR-122-3p NTM -1.75369011054591 1.52070648599898e-11 1.33853224720958 0.000643118047043159 miRNATAP -0.595092010865499 9.60921036628071e-18 NA NA NA hsa-miR-28-5p NTM -0.430964830599964 2.67367257252925e-06 1.33853224720958 0.000643118047043159 miRanda;miRNATAP -1.2116782974839 4.37177672500027e-09 NA NA NA hsa-miR-30b-3p NTM -0.439724365151373 0.000947180503583586 1.33853224720958 0.000643118047043159 MirTarget -0.455751825523542 0.00158593539097753 NA NA NA hsa-miR-33a-3p NTM -0.683025859637737 1.01106097756419e-05 1.33853224720958 0.000643118047043159 mirMAP -0.715165119353838 4.00902905979745e-09 NA NA NA hsa-miR-374b-5p NTM -0.307538028546424 0.0030079617545972 1.33853224720958 0.000643118047043159 miRNATAP -0.56668379643383 0.00236848413975055 NA NA NA hsa-miR-618 NTM 0.13539895350352 0.517145913114103 1.33853224720958 0.000643118047043159 miRNATAP -0.497304224664957 1.32101498258022e-07 NA NA NA hsa-miR-29c-3p OXTR -1.4367517608807 1.61767774905781e-21 0.808924093526337 0.00174396860147485 miRNATAP -0.25383793596229 0.00145641278329754 NA NA NA hsa-miR-30e-3p OXTR -1.20845647373031 3.10263633528203e-25 0.808924093526337 0.00174396860147485 mirMAP -0.450378875787133 1.0245816370417e-05 NA NA NA hsa-miR-215-5p PCOLCE2 -0.981544773246509 3.14452272477156e-05 -0.290703988032813 0.388022584574282 miRNAWalker2_validate -0.253873956699374 0.000217496345803066 NA NA NA hsa-miR-92b-3p PCOLCE2 0.220374930803974 0.296187538889092 -0.290703988032813 0.388022584574282 MirTarget -0.414627340026662 6.76267176988459e-08 NA NA NA hsa-miR-28-5p PDGFRB -0.430964830599964 2.67367257252925e-06 0.903688818724302 2.6429876964178e-08 miRanda -0.310145998507964 0.000393892179655548 NA NA NA hsa-miR-29a-3p PDGFRB -0.856762511178136 4.65330336378459e-12 0.903688818724302 2.6429876964178e-08 miRNATAP -0.17841922996433 0.00500595280694788 NA NA NA hsa-miR-29c-3p PDGFRB -1.4367517608807 1.61767774905781e-21 0.903688818724302 2.6429876964178e-08 miRNATAP -0.139148992716859 0.00615874031219039 NA NA NA hsa-miR-486-5p PDGFRB -1.77766890600022 2.9071717929922e-14 0.903688818724302 2.6429876964178e-08 miRanda -0.142065402424595 1.73938186674638e-05 NA NA NA hsa-miR-28-5p PDLIM4 -0.430964830599964 2.67367257252925e-06 0.022601276362501 0.939149291848207 miRanda -0.471011855453255 0.00271364365663584 NA NA NA hsa-miR-194-5p PFN2 -0.292530160992458 0.0996141384876663 -1.30384490866722 4.73283772543551e-07 miRNATAP -0.441920192028256 4.19644133094824e-10 NA NA NA hsa-miR-30d-5p PFN2 0.718283816348023 2.47422074061352e-08 -1.30384490866722 4.73283772543551e-07 MirTarget;miRNATAP -0.553906715609642 9.92723652138389e-09 NA NA NA hsa-miR-139-5p PLAUR -2.11299531796557 8.16407076415038e-28 -0.875686346227218 2.89876634414617e-05 miRanda -0.166369184739737 0.000811117505885107 NA NA NA hsa-miR-204-5p PLAUR -0.537962150012103 0.0330895493358849 -0.875686346227218 2.89876634414617e-05 miRNAWalker2_validate -0.213288433563427 1.17211425028353e-07 NA NA NA hsa-let-7a-5p PLOD1 -0.328069937201898 0.000464344093744051 0.183475365938223 0.101859018616887 miRNAWalker2_validate -0.191646319875312 0.0010490924804916 NA NA NA hsa-miR-335-5p PLOD1 -1.61347836513558 1.62757083289711e-19 0.183475365938223 0.101859018616887 MirTarget -0.129479074225061 7.87244570607516e-06 NA NA NA hsa-miR-140-5p PLOD3 -0.220106443070144 0.0140713197101242 0.970287711964061 6.77314345089972e-22 miRanda -0.19760905012226 0.000690678361530552 NA NA NA hsa-miR-326 PLOD3 -1.881935132554 1.68087316863775e-21 0.970287711964061 6.77314345089972e-22 miRNATAP -0.111595564857511 7.49708231343915e-06 NA NA NA hsa-miR-107 PMEPA1 0.241662461253461 0.0170788899505389 -0.100015742263655 0.700739861057591 mirMAP -0.98197799558 7.79516529522153e-16 NA NA NA hsa-miR-130b-3p PMEPA1 0.687190305027546 0.000109068658562255 -0.100015742263655 0.700739861057591 MirTarget;miRNATAP -0.312598670029447 8.9164643552055e-06 NA NA NA hsa-miR-15a-5p PMEPA1 0.349521211668244 0.000770735998804736 -0.100015742263655 0.700739861057591 mirMAP -0.530371137330692 1.28820983743842e-05 NA NA NA hsa-miR-192-3p PMEPA1 -0.6401165114007 0.000266272092403814 -0.100015742263655 0.700739861057591 mirMAP -0.661419885758132 3.1941002031372e-22 NA NA NA hsa-miR-32-5p PMEPA1 0.0806126674664016 0.548984992497432 -0.100015742263655 0.700739861057591 miRNATAP -0.400887603432288 2.05124609793586e-05 NA NA NA hsa-miR-486-5p PMEPA1 -1.77766890600022 2.9071717929922e-14 -0.100015742263655 0.700739861057591 miRanda -0.217182832596736 3.06421317462291e-05 NA NA NA hsa-miR-532-3p PMEPA1 0.297601533259956 0.014632205884815 -0.100015742263655 0.700739861057591 mirMAP -0.395084340935005 0.000143522110083201 NA NA NA hsa-miR-589-5p PMEPA1 1.18593770505086 1.01781241960531e-22 -0.100015742263655 0.700739861057591 mirMAP -0.406990666007528 4.08897551458712e-05 NA NA NA hsa-miR-616-5p PMEPA1 0.150569904638223 0.402836556304524 -0.100015742263655 0.700739861057591 mirMAP;miRNATAP -0.49806022225429 4.78522170457348e-13 NA NA NA hsa-miR-618 PMEPA1 0.13539895350352 0.517145913114103 -0.100015742263655 0.700739861057591 miRNATAP -0.553667652426243 2.95404703234494e-20 NA NA NA hsa-miR-92a-3p PMEPA1 0.212391012518195 0.134292268089997 -0.100015742263655 0.700739861057591 miRNATAP -0.274841590893096 0.0021482236830093 NA NA NA hsa-miR-122-5p PMP22 -1.23907441373955 4.42181244888642e-06 -0.347849765491887 0.0493716032897198 miRNAWalker2_validate -0.275476326112181 7.42736713045936e-20 NA NA NA hsa-miR-361-5p PMP22 0.233202959858696 0.00961572812255327 -0.347849765491887 0.0493716032897198 miRanda -0.487100290859958 3.75422922310239e-07 NA NA NA hsa-miR-651-5p PMP22 -0.244364876887077 0.0817536678437599 -0.347849765491887 0.0493716032897198 MirTarget -0.163957743106066 0.0081363867399535 NA NA NA hsa-let-7c-5p PRRX1 -1.70744661345097 2.87934212005942e-20 2.13747637731194 2.98162416691034e-16 MirTarget -0.352682612593982 1.66283334492681e-07 NA NA NA hsa-miR-139-5p PRRX1 -2.11299531796557 8.16407076415038e-28 2.13747637731194 2.98162416691034e-16 miRanda -0.413332770721526 4.20600441623531e-11 NA NA NA hsa-miR-144-3p PRRX1 -2.97536914478815 6.00546047309683e-28 2.13747637731194 2.98162416691034e-16 MirTarget -0.247066633301929 3.67426832432359e-08 NA NA NA hsa-miR-146b-3p PRRX1 -1.20799545896423 2.19859530890688e-09 2.13747637731194 2.98162416691034e-16 PITA -0.187048529106812 0.00360737181664666 24946010 The roles of the epithelial mesenchymal transition marker PRRX1 and miR 146b 5p in papillary thyroid carcinoma progression progression thyroid cancer hsa-miR-204-5p PRRX1 -0.537962150012103 0.0330895493358849 2.13747637731194 2.98162416691034e-16 MirTarget;miRNATAP -0.192898344637639 0.000220116362054934 NA NA NA hsa-miR-26b-3p PRRX1 -1.25503731613309 4.45390890119649e-27 2.13747637731194 2.98162416691034e-16 MirTarget -0.668012536235449 1.97507494214254e-10 NA NA NA hsa-miR-374b-5p PRRX1 -0.307538028546424 0.0030079617545972 2.13747637731194 2.98162416691034e-16 mirMAP -0.416919207819162 0.00115128748388561 NA NA NA hsa-miR-455-5p PRRX1 -0.270546034117157 0.0581320703577731 2.13747637731194 2.98162416691034e-16 miRanda -0.500366368942583 4.97619348289253e-08 NA NA NA hsa-miR-486-5p PRRX1 -1.77766890600022 2.9071717929922e-14 2.13747637731194 2.98162416691034e-16 miRanda -0.262580247468742 1.2998046969669e-06 NA NA NA hsa-miR-616-5p PRRX1 0.150569904638223 0.402836556304524 2.13747637731194 2.98162416691034e-16 mirMAP -0.229193099857166 0.0019064561937888 NA NA NA hsa-miR-618 PRRX1 0.13539895350352 0.517145913114103 2.13747637731194 2.98162416691034e-16 mirMAP -0.337882373643889 1.95005105832779e-07 NA NA NA hsa-miR-107 PTHLH 0.241662461253461 0.0170788899505389 1.18418240379439 0.00181078859052455 miRanda -0.85733929793955 2.9589806812676e-06 NA NA NA hsa-miR-126-5p PTHLH -0.428561469405594 6.6035585844222e-05 1.18418240379439 0.00181078859052455 mirMAP -0.535473298431582 0.0019658042928415 NA NA NA hsa-miR-139-5p PTHLH -2.11299531796557 8.16407076415038e-28 1.18418240379439 0.00181078859052455 miRanda -0.65575459178869 5.88525642650456e-14 NA NA NA hsa-miR-144-3p PTHLH -2.97536914478815 6.00546047309683e-28 1.18418240379439 0.00181078859052455 MirTarget -0.282328978701772 8.45868292734408e-06 NA NA NA hsa-miR-29c-3p PTHLH -1.4367517608807 1.61767774905781e-21 1.18418240379439 0.00181078859052455 MirTarget -0.548905210937142 2.37742693690382e-06 NA NA NA hsa-miR-576-5p PTHLH -0.377452008285847 0.00470735657343984 1.18418240379439 0.00181078859052455 MirTarget;PITA -0.441478208082617 0.00151246342155359 NA NA NA hsa-miR-101-5p QSOX1 -1.0634649894055 4.39116719827902e-16 -0.998176284579899 0.000345773632396881 mirMAP -0.312845112654859 0.00196430152125769 NA NA NA hsa-miR-1269a QSOX1 3.57543539205634 4.25369619949175e-08 -0.998176284579899 0.000345773632396881 mirMAP -0.170756713227239 3.09015670893304e-16 NA NA NA hsa-miR-146b-5p QSOX1 0.419719546795449 0.0457375823220155 -0.998176284579899 0.000345773632396881 miRanda -0.20676968607399 0.00145889137327504 NA NA NA hsa-miR-192-3p QSOX1 -0.6401165114007 0.000266272092403814 -0.998176284579899 0.000345773632396881 mirMAP -0.520172288134819 6.48887635107979e-12 NA NA NA hsa-miR-192-5p QSOX1 -0.50188499512787 0.00344713341196035 -0.998176284579899 0.000345773632396881 mirMAP -0.556359066488718 7.12939650913052e-13 NA NA NA hsa-miR-193b-3p QSOX1 -0.166697207281748 0.272022543069482 -0.998176284579899 0.000345773632396881 mirMAP -0.788307712332 8.38028575359447e-20 NA NA NA hsa-miR-28-5p QSOX1 -0.430964830599964 2.67367257252925e-06 -0.998176284579899 0.000345773632396881 miRanda -0.588986435873847 7.32737683672579e-05 NA NA NA hsa-miR-29a-5p QSOX1 -0.113555908626946 0.349622266470788 -0.998176284579899 0.000345773632396881 mirMAP -0.361281930697838 0.00143417476207028 NA NA NA hsa-miR-32-3p QSOX1 0.219109440121582 0.207217051619543 -0.998176284579899 0.000345773632396881 mirMAP -0.286728452700405 0.000418893706702801 NA NA NA hsa-miR-32-5p QSOX1 0.0806126674664016 0.548984992497432 -0.998176284579899 0.000345773632396881 mirMAP -0.483067245637381 1.89122073408722e-06 NA NA NA hsa-miR-34a-5p QSOX1 1.03694231790865 5.74864019540594e-14 -0.998176284579899 0.000345773632396881 mirMAP -0.644990627282221 7.46441108185982e-12 NA NA NA hsa-miR-362-3p QSOX1 0.814007335895913 2.00108618836568e-09 -0.998176284579899 0.000345773632396881 MirTarget;miRanda;miRNATAP -0.263279089026871 0.00800389734378915 NA NA NA hsa-miR-365a-3p QSOX1 0.164591326307714 0.15325084963213 -0.998176284579899 0.000345773632396881 mirMAP -0.827038039613798 1.32790530066688e-12 NA NA NA hsa-miR-378a-3p QSOX1 -1.1920055906972 3.23538871733634e-10 -0.998176284579899 0.000345773632396881 mirMAP -0.51782535223538 4.43516220128527e-14 NA NA NA hsa-miR-378a-5p QSOX1 -1.58667444700188 3.19640857320504e-17 -0.998176284579899 0.000345773632396881 mirMAP -0.443790001938452 9.3902281776454e-11 NA NA NA hsa-miR-378c QSOX1 -1.54028191929038 2.70131554214866e-15 -0.998176284579899 0.000345773632396881 mirMAP -0.43699869329929 4.59182015835309e-11 NA NA NA hsa-miR-616-5p QSOX1 0.150569904638223 0.402836556304524 -0.998176284579899 0.000345773632396881 mirMAP -0.281579482306115 0.000216039242917758 NA NA NA hsa-miR-618 QSOX1 0.13539895350352 0.517145913114103 -0.998176284579899 0.000345773632396881 mirMAP -0.376936934455586 1.76956539610222e-08 NA NA NA hsa-miR-103a-3p RGS4 0.765568928457606 3.05497476509383e-12 -1.45690815898734 2.10409887435192e-06 MirTarget;miRNATAP -0.520542615007527 0.000113069109372765 NA NA NA hsa-miR-107 RGS4 0.241662461253461 0.0170788899505389 -1.45690815898734 2.10409887435192e-06 MirTarget;miRanda;miRNATAP -1.1572811678579 2.22417011707909e-15 NA NA NA hsa-miR-17-5p RGS4 0.698861147045461 2.43854106455398e-05 -1.45690815898734 2.10409887435192e-06 TargetScan -0.380334381045009 2.53402397837648e-05 NA NA NA hsa-miR-374a-5p RGS4 0.016390363747302 0.869784217438621 -1.45690815898734 2.10409887435192e-06 MirTarget -0.827810683466306 4.56903900909881e-08 NA NA NA hsa-miR-374b-5p RGS4 -0.307538028546424 0.0030079617545972 -1.45690815898734 2.10409887435192e-06 MirTarget -0.485993933400401 0.000928808533420202 NA NA NA hsa-miR-421 RGS4 0.941856334694081 6.12167297054077e-08 -1.45690815898734 2.10409887435192e-06 miRanda -0.306450236442721 0.000363066824236474 NA NA NA hsa-miR-455-5p RGS4 -0.270546034117157 0.0581320703577731 -1.45690815898734 2.10409887435192e-06 PITA;miRanda -0.345862139770033 0.00113332396078148 NA NA NA hsa-miR-616-5p RGS4 0.150569904638223 0.402836556304524 -1.45690815898734 2.10409887435192e-06 MirTarget;mirMAP -0.44752780560386 8.49422685295093e-08 NA NA NA hsa-miR-664a-3p RGS4 0.485807855553031 0.000732553249798598 -1.45690815898734 2.10409887435192e-06 mirMAP -0.289302623827742 0.00593656447868251 NA NA NA hsa-miR-183-5p RHOB 2.33444328833177 1.52188109365421e-10 -1.7358770639627 5.43143135520556e-23 miRNATAP -0.221090412916379 8.85138510305554e-22 NA NA NA hsa-miR-19a-3p RHOB 1.01712596153672 2.57753201450625e-07 -1.7358770639627 5.43143135520556e-23 MirTarget;miRNATAP -0.24398027247404 4.60473351235685e-08 26041879 Ras homolog family member B RHOB was identified as a direct target of miR-19a pancreatic cancer hsa-miR-19b-3p RHOB 0.601279551368824 0.00016685097085251 -1.7358770639627 5.43143135520556e-23 MirTarget;miRNATAP -0.252457126016046 6.53608860264224e-06 NA NA NA hsa-miR-21-5p RHOB 1.51084295924322 1.54551622173259e-34 -1.7358770639627 5.43143135520556e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.561330691774606 7.06300169113094e-18 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-224-3p RHOB 1.40770116795301 1.31426607144612e-08 -1.7358770639627 5.43143135520556e-23 mirMAP -0.113116500008515 0.00184583486508887 NA NA NA hsa-miR-30d-5p RHOB 0.718283816348023 2.47422074061352e-08 -1.7358770639627 5.43143135520556e-23 miRNATAP -0.189798031918867 0.00628110880080144 NA NA NA hsa-miR-330-3p RHOB -0.332364259424489 0.0316051913061459 -1.7358770639627 5.43143135520556e-23 MirTarget;miRNATAP -0.232432404273499 9.90253152784531e-05 NA NA NA hsa-miR-362-3p RHOB 0.814007335895913 2.00108618836568e-09 -1.7358770639627 5.43143135520556e-23 miRanda -0.248706049228794 0.000143532107015008 NA NA NA hsa-miR-421 RHOB 0.941856334694081 6.12167297054077e-08 -1.7358770639627 5.43143135520556e-23 miRNAWalker2_validate -0.360456276596774 6.86037224408297e-13 NA NA NA hsa-miR-629-3p RHOB -0.315338123880353 0.119091248294946 -1.7358770639627 5.43143135520556e-23 mirMAP -0.267462642718584 3.5449304259595e-09 NA NA NA hsa-miR-940 RHOB 0.453020092551484 0.0177054921651997 -1.7358770639627 5.43143135520556e-23 MirTarget -0.31264976199892 5.84854067207289e-11 NA NA NA hsa-miR-107 SAT1 0.241662461253461 0.0170788899505389 -0.88727386577601 5.46294149352197e-11 miRNAWalker2_validate;miRanda -0.21430181015807 0.00138920431557467 NA NA NA hsa-miR-186-5p SAT1 -0.060103391373687 0.535288717081205 -0.88727386577601 5.46294149352197e-11 miRNATAP -0.220059904991463 0.00177190710627142 NA NA NA hsa-miR-320a SAT1 0.325285936317332 0.0221415065838824 -0.88727386577601 5.46294149352197e-11 miRanda;miRNATAP -0.163123416965667 0.000582360276850345 NA NA NA hsa-miR-590-5p SAT1 -0.103355559980404 0.310027295317092 -0.88727386577601 5.46294149352197e-11 miRanda -0.2828322209089 2.1590617599582e-05 NA NA NA hsa-miR-652-3p SAT1 0.135945800164278 0.391695970197646 -0.88727386577601 5.46294149352197e-11 miRNAWalker2_validate -0.123437103697464 0.00378229152616883 NA NA NA hsa-miR-744-5p SAT1 -0.378868377317939 0.00125071229180016 -0.88727386577601 5.46294149352197e-11 miRNAWalker2_validate -0.159659668653099 0.00555443563987227 NA NA NA hsa-miR-139-5p SCG2 -2.11299531796557 8.16407076415038e-28 2.05291381366087 9.19914474865242e-11 miRanda -0.355261449512469 2.77194195866124e-06 NA NA NA hsa-miR-30b-3p SCG2 -0.439724365151373 0.000947180503583586 2.05291381366087 9.19914474865242e-11 MirTarget -0.454318458379343 0.000123113396782727 NA NA NA hsa-miR-486-5p SCG2 -1.77766890600022 2.9071717929922e-14 2.05291381366087 9.19914474865242e-11 miRanda;miRNATAP -0.315539820160787 1.11358886457046e-06 NA NA NA hsa-miR-505-3p SCG2 -1.20027021591555 1.27927500175937e-13 2.05291381366087 9.19914474865242e-11 MirTarget -0.386423234427605 4.16430546356243e-05 NA NA NA hsa-miR-10a-5p SDC1 -1.47723516092033 7.27299669108673e-16 -0.470843337275294 0.000957806893571993 MirTarget;miRNATAP -0.100562240460913 0.00620261002966119 NA NA NA hsa-miR-125a-5p SDC1 -0.91219969372382 1.38256246489548e-07 -0.470843337275294 0.000957806893571993 mirMAP -0.242506399881867 5.07852681303094e-10 NA NA NA hsa-miR-149-5p SDC1 -0.317176971910036 0.187207559733877 -0.470843337275294 0.000957806893571993 miRNAWalker2_validate -0.10788925032969 0.000203647907771648 25462564 In this study we examined the expression of miRNA-126 miR-126 and miR-149 in prostate cancer and investigated the molecular mechanisms by which they affect syndecan-1 in prostate cancer; After silencing syndecan-1 miR-126 and/or miR-149 in the PC3 cells cell proliferation senescence and p21 induction were assessed using the MTS assay senescence-associated β-galactosidase SA-β-Gal assay and immunocytochemistry respectively; When syndecan-1 was silenced the PC3 cells showed reduced expression of miR-126 and miR-149 most effectively; Our results suggest that miR-126 and miR-149 are associated with the expression of syndecan-1 in prostate cancer cells prostate cancer hsa-miR-18a-5p SDC1 0.918028187958706 1.90229510425322e-05 -0.470843337275294 0.000957806893571993 mirMAP -0.23147681495373 1.39748610764677e-13 NA NA NA hsa-miR-19a-3p SDC1 1.01712596153672 2.57753201450625e-07 -0.470843337275294 0.000957806893571993 MirTarget;miRNATAP -0.138353639537011 6.59457346076957e-05 NA NA NA hsa-miR-19b-3p SDC1 0.601279551368824 0.00016685097085251 -0.470843337275294 0.000957806893571993 MirTarget;miRNATAP -0.148688026990416 0.000605133639175132 NA NA NA hsa-miR-330-3p SDC1 -0.332364259424489 0.0316051913061459 -0.470843337275294 0.000957806893571993 mirMAP -0.236364368747859 2.28084273859912e-07 NA NA NA hsa-miR-338-3p SDC1 0.543135607704581 0.00461167747143826 -0.470843337275294 0.000957806893571993 miRanda -0.15577061487965 1.54994870801071e-05 NA NA NA hsa-miR-339-5p SDC1 0.280589919878422 0.0355660282647215 -0.470843337275294 0.000957806893571993 miRanda -0.138141014197714 0.0084474773529185 NA NA NA hsa-miR-342-3p SDC1 -0.319677314984262 0.0449813878317147 -0.470843337275294 0.000957806893571993 miRanda;mirMAP -0.236448754975639 4.49909497952238e-08 NA NA NA hsa-miR-140-3p SDC4 0.546012239205329 4.84578261098777e-11 -1.18352065496432 6.93834154336227e-16 MirTarget -0.618418958148392 7.5118873372647e-13 NA NA NA hsa-miR-301a-3p SDC4 0.842910511640361 1.43446467417891e-06 -1.18352065496432 6.93834154336227e-16 MirTarget -0.153056005484411 0.000246708748625281 NA NA NA hsa-miR-454-3p SDC4 0.668749059573955 2.42670710515113e-06 -1.18352065496432 6.93834154336227e-16 MirTarget -0.188460504619605 0.000261590080467209 NA NA NA hsa-miR-589-3p SDC4 1.16846704028095 5.88525574424201e-11 -1.18352065496432 6.93834154336227e-16 mirMAP -0.131283314200761 0.00152340252745206 NA NA NA hsa-miR-942-5p SDC4 0.346451845105263 0.0283255399972342 -1.18352065496432 6.93834154336227e-16 MirTarget -0.16380426972956 0.000465547582277858 NA NA NA hsa-miR-148a-5p SERPINE1 -0.767626696027761 1.08359477494797e-06 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.260590457035894 0.00415058434081855 NA NA NA hsa-miR-30d-5p SERPINE1 0.718283816348023 2.47422074061352e-08 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.510774042367725 3.44422983628064e-06 NA NA NA hsa-miR-34a-5p SERPINE1 1.03694231790865 5.74864019540594e-14 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.399999110948681 8.04313907897335e-05 NA NA NA hsa-miR-30e-3p SERPINE2 -1.20845647373031 3.10263633528203e-25 -0.017155914066354 0.956051903268475 miRNAWalker2_validate -0.554355532152891 5.7363709512593e-06 NA NA NA hsa-miR-26b-5p SERPINH1 -1.10804856399744 4.14176110314282e-22 0.857204942663188 1.18245152144085e-10 miRNAWalker2_validate -0.277524606215859 3.71919854382961e-07 NA NA NA hsa-miR-29a-3p SERPINH1 -0.856762511178136 4.65330336378459e-12 0.857204942663188 1.18245152144085e-10 miRNATAP -0.436404643505229 4.29698536123465e-18 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA 29a in lung cancer with idiopathic pulmonary fibrosis; Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF suggesting that these genes are involved in the pathogenesis of these two diseases.Journal of Human Genetics advance online publication 4 August 2016; doi:10.1038/jhg.2016.99 staging lung cancer hsa-miR-29b-3p SERPINH1 -0.348885528720517 0.0121441341291285 0.857204942663188 1.18245152144085e-10 miRNATAP -0.210435139438807 8.95416408871879e-06 NA NA NA hsa-miR-29c-3p SERPINH1 -1.4367517608807 1.61767774905781e-21 0.857204942663188 1.18245152144085e-10 miRNATAP -0.352115575249427 1.86537676248473e-18 NA NA NA hsa-miR-1301-3p SFRP1 1.12156714169769 4.22404125385203e-10 -4.14637823674297 1.04005427998815e-32 MirTarget -0.326166528078997 0.00113518434436241 NA NA NA hsa-miR-16-1-3p SFRP1 0.392360028038559 0.00112481918108198 -4.14637823674297 1.04005427998815e-32 MirTarget -0.71551742776429 2.38771391079108e-06 NA NA NA hsa-miR-192-3p SFRP1 -0.6401165114007 0.000266272092403814 -4.14637823674297 1.04005427998815e-32 MirTarget -0.424962367232444 4.17845072192868e-05 NA NA NA hsa-miR-501-5p SFRP1 1.15231083477882 2.98906150004088e-10 -4.14637823674297 1.04005427998815e-32 mirMAP -0.477662273757518 1.00728429943687e-06 NA NA NA hsa-miR-548b-3p SFRP1 -0.0203576084717134 0.930819503166956 -4.14637823674297 1.04005427998815e-32 mirMAP -0.432545827935783 3.67109378834241e-08 NA NA NA hsa-miR-548j-5p SFRP1 0.251239647701947 0.171361975450222 -4.14637823674297 1.04005427998815e-32 MirTarget -0.453370953209203 1.05214745425183e-05 NA NA NA hsa-miR-144-5p SFRP4 -1.54604938792018 1.06886492586611e-10 2.13318024807939 8.83329524470029e-10 MirTarget -0.351626376323752 4.90563413861651e-07 NA NA NA hsa-miR-26b-5p SFRP4 -1.10804856399744 4.14176110314282e-22 2.13318024807939 8.83329524470029e-10 miRNAWalker2_validate -0.774813965686543 5.2927899458002e-08 NA NA NA hsa-miR-3607-3p SFRP4 -2.15518588554493 1.03390728226728e-23 2.13318024807939 8.83329524470029e-10 MirTarget -0.343276705360189 5.59321744727563e-06 NA NA NA hsa-miR-21-5p SGCB 1.51084295924322 1.54551622173259e-34 -0.991863016074027 7.13504872359113e-06 miRNAWalker2_validate -0.408063134168544 4.09056141654257e-07 NA NA NA hsa-miR-30d-5p SGCB 0.718283816348023 2.47422074061352e-08 -0.991863016074027 7.13504872359113e-06 miRNATAP -0.468453779003497 1.21542914547044e-08 NA NA NA hsa-miR-103a-3p SGCD 0.765568928457606 3.05497476509383e-12 -2.19675212080742 3.14480928648648e-10 mirMAP -0.607504213456775 8.68413981004149e-05 NA NA NA hsa-miR-106b-5p SGCD 0.648901865047099 8.24870862047885e-09 -2.19675212080742 3.14480928648648e-10 mirMAP -0.966787524363987 1.10685609079265e-10 NA NA NA hsa-miR-107 SGCD 0.241662461253461 0.0170788899505389 -2.19675212080742 3.14480928648648e-10 mirMAP -0.849544890648887 7.24059497530493e-07 NA NA NA hsa-miR-148a-5p SGCD -0.767626696027761 1.08359477494797e-06 -2.19675212080742 3.14480928648648e-10 mirMAP -0.311010361789749 0.0044610667733004 NA NA NA hsa-miR-15a-5p SGCD 0.349521211668244 0.000770735998804736 -2.19675212080742 3.14480928648648e-10 miRNATAP -0.603284840336993 0.000319777839971041 NA NA NA hsa-miR-17-5p SGCD 0.698861147045461 2.43854106455398e-05 -2.19675212080742 3.14480928648648e-10 mirMAP -0.640959604029544 3.84958476172617e-10 NA NA NA hsa-miR-19a-3p SGCD 1.01712596153672 2.57753201450625e-07 -2.19675212080742 3.14480928648648e-10 mirMAP -0.418160391419658 1.19517884861129e-06 NA NA NA hsa-miR-19b-3p SGCD 0.601279551368824 0.00016685097085251 -2.19675212080742 3.14480928648648e-10 mirMAP -0.521974176567477 1.17565847476234e-06 NA NA NA hsa-miR-20a-5p SGCD 0.854326758727003 5.04256669663285e-07 -2.19675212080742 3.14480928648648e-10 mirMAP -0.68633576289089 3.5926399780433e-12 NA NA NA hsa-miR-25-3p SGCD 0.633062563556379 3.68686354834328e-10 -2.19675212080742 3.14480928648648e-10 mirMAP -0.89414279212775 1.05527019496621e-07 NA NA NA hsa-miR-32-3p SGCD 0.219109440121582 0.207217051619543 -2.19675212080742 3.14480928648648e-10 mirMAP -0.311074174683721 0.0026728712388278 NA NA NA hsa-miR-32-5p SGCD 0.0806126674664016 0.548984992497432 -2.19675212080742 3.14480928648648e-10 mirMAP -0.568968769995172 1.06475011940225e-05 NA NA NA hsa-miR-362-3p SGCD 0.814007335895913 2.00108618836568e-09 -2.19675212080742 3.14480928648648e-10 miRNATAP -0.361541029113232 0.00416787831632103 NA NA NA hsa-miR-3682-3p SGCD 0.805600143458555 8.7874424633131e-06 -2.19675212080742 3.14480928648648e-10 mirMAP -0.401660464492958 4.72500208509743e-05 NA NA NA hsa-miR-532-5p SGCD 1.02729546510601 9.93318913966636e-16 -2.19675212080742 3.14480928648648e-10 PITA -0.710940086832016 4.55690396726603e-08 NA NA NA hsa-miR-548b-3p SGCD -0.0203576084717134 0.930819503166956 -2.19675212080742 3.14480928648648e-10 PITA;miRNATAP -0.412063170504348 2.8828414621559e-08 NA NA NA hsa-miR-589-3p SGCD 1.16846704028095 5.88525574424201e-11 -2.19675212080742 3.14480928648648e-10 mirMAP -0.264850710167653 0.00656274379021042 NA NA NA hsa-miR-590-5p SGCD -0.103355559980404 0.310027295317092 -2.19675212080742 3.14480928648648e-10 miRanda -0.547648084693286 0.00150779572540884 NA NA NA hsa-miR-616-5p SGCD 0.150569904638223 0.402836556304524 -2.19675212080742 3.14480928648648e-10 miRNATAP -0.394535163213889 4.45225632271111e-05 NA NA NA hsa-miR-618 SGCD 0.13539895350352 0.517145913114103 -2.19675212080742 3.14480928648648e-10 mirMAP -0.484226155413377 1.2574149636304e-08 NA NA NA hsa-miR-92a-3p SGCD 0.212391012518195 0.134292268089997 -2.19675212080742 3.14480928648648e-10 mirMAP -0.709390891389025 4.86155706187664e-09 NA NA NA hsa-miR-93-5p SGCD 1.39518349670953 2.84167728726712e-25 -2.19675212080742 3.14480928648648e-10 mirMAP -0.870954002648103 2.52960537335977e-13 NA NA NA hsa-let-7b-3p SLC6A8 -1.21979213547786 5.84575581584603e-17 1.8315213767408 1.85297000947132e-08 miRNATAP -0.399793832027341 0.000171678122696902 NA NA NA hsa-miR-92a-3p SLC6A8 0.212391012518195 0.134292268089997 1.8315213767408 1.85297000947132e-08 miRNAWalker2_validate -0.295888369830578 0.00967835459573744 NA NA NA hsa-miR-130b-3p SLIT3 0.687190305027546 0.000109068658562255 0.157466553388729 0.504736595264199 mirMAP -0.187682496032218 0.00349725185843067 NA NA NA hsa-miR-130b-5p SLIT3 0.170599813152408 0.337611586432771 0.157466553388729 0.504736595264199 mirMAP -0.251439296510219 9.52843955448706e-05 NA NA NA hsa-miR-148a-5p SLIT3 -0.767626696027761 1.08359477494797e-06 0.157466553388729 0.504736595264199 MirTarget;miRNATAP -0.386272237761703 6.07756382639517e-08 NA NA NA hsa-miR-16-2-3p SLIT3 -0.0336420826463706 0.805158952566973 0.157466553388729 0.504736595264199 mirMAP -0.282078241901337 0.000851038507026978 NA NA NA hsa-miR-192-5p SLIT3 -0.50188499512787 0.00344713341196035 0.157466553388729 0.504736595264199 mirMAP -0.470658969765089 4.74981152368516e-13 NA NA NA hsa-miR-28-5p SLIT3 -0.430964830599964 2.67367257252925e-06 0.157466553388729 0.504736595264199 miRanda -0.423393097387198 0.000710932929038662 NA NA NA hsa-miR-301a-3p SLIT3 0.842910511640361 1.43446467417891e-06 0.157466553388729 0.504736595264199 mirMAP -0.170610303751472 0.00869316401828249 NA NA NA hsa-miR-33a-3p SLIT3 -0.683025859637737 1.01106097756419e-05 0.157466553388729 0.504736595264199 mirMAP -0.305000803540192 3.24049957877902e-05 NA NA NA hsa-miR-3682-3p SLIT3 0.805600143458555 8.7874424633131e-06 0.157466553388729 0.504736595264199 mirMAP -0.191968666388205 0.00337910677247748 NA NA NA hsa-miR-374a-5p SLIT3 0.016390363747302 0.869784217438621 0.157466553388729 0.504736595264199 MirTarget -0.45975270769614 7.16448328236328e-05 NA NA NA hsa-miR-374b-5p SLIT3 -0.307538028546424 0.0030079617545972 0.157466553388729 0.504736595264199 MirTarget -0.369045646318901 0.000913422309388 NA NA NA hsa-miR-550a-3p SLIT3 0.0421988124005088 0.798971000685886 0.157466553388729 0.504736595264199 mirMAP -0.293470293249914 3.11817970541428e-05 NA NA NA hsa-miR-589-3p SLIT3 1.16846704028095 5.88525574424201e-11 0.157466553388729 0.504736595264199 mirMAP -0.251228076733407 8.72809944157636e-05 NA NA NA hsa-miR-590-3p SLIT3 -0.473167498047808 1.76652934637227e-05 0.157466553388729 0.504736595264199 miRanda;mirMAP -0.437241341640478 2.38107232617968e-05 NA NA NA hsa-miR-590-5p SLIT3 -0.103355559980404 0.310027295317092 0.157466553388729 0.504736595264199 miRanda -0.671917228641153 2.13854113716698e-09 NA NA NA hsa-miR-616-5p SLIT3 0.150569904638223 0.402836556304524 0.157466553388729 0.504736595264199 mirMAP -0.382453510093364 1.31586861507375e-09 NA NA NA hsa-miR-148b-3p SNAI2 0.266862251671911 0.00185271302045935 0.384447886331124 0.102927984369101 miRNAWalker2_validate -0.544029940642456 5.49522288288826e-05 NA NA NA hsa-miR-181a-5p SNAI2 0.250113435902954 0.0551933249319293 0.384447886331124 0.102927984369101 miRNAWalker2_validate -0.261350612158367 0.00311299103180595 NA NA NA hsa-miR-182-5p SNAI2 1.96601340710222 4.39326175603633e-09 0.384447886331124 0.102927984369101 miRNAWalker2_validate;miRNATAP -0.103835953273872 0.00197162374541916 NA NA NA hsa-miR-200b-3p SNAI2 -1.29335788099229 0.000268623234305059 0.384447886331124 0.102927984369101 TargetScan -0.113933336744523 0.000370832757095312 NA NA NA hsa-miR-200c-3p SNAI2 -0.104675615392797 0.716957669484981 0.384447886331124 0.102927984369101 miRNATAP -0.13296318092996 0.000812112160068585 NA NA NA hsa-miR-320a SNAI2 0.325285936317332 0.0221415065838824 0.384447886331124 0.102927984369101 miRanda -0.214409102466517 0.00813189487988791 NA NA NA hsa-miR-320b SNAI2 0.0919652022571331 0.607981643616945 0.384447886331124 0.102927984369101 miRanda -0.202087227587785 0.00173449253044878 NA NA NA hsa-miR-330-3p SNAI2 -0.332364259424489 0.0316051913061459 0.384447886331124 0.102927984369101 PITA -0.196504661120588 0.00986696206545639 NA NA NA hsa-miR-335-3p SNAI2 -0.275199247483111 0.106629165248783 0.384447886331124 0.102927984369101 mirMAP -0.217340446715799 0.00125313566599525 NA NA NA hsa-miR-375 SNAI2 -1.93190458972328 4.28108492522e-06 0.384447886331124 0.102927984369101 miRanda -0.209046657886176 1.12811819223104e-15 NA NA NA hsa-miR-429 SNAI2 -1.40262535827285 6.93982219171912e-05 0.384447886331124 0.102927984369101 PITA;miRanda;miRNATAP -0.124379059709461 0.000134132733571897 NA NA NA hsa-miR-16-2-3p SNTB1 -0.0336420826463706 0.805158952566973 -0.293060521048924 0.0493505232517265 mirMAP -0.229568457311439 1.61166516902721e-05 NA NA NA hsa-miR-24-3p SNTB1 -0.257825594021966 0.00689742600215061 -0.293060521048924 0.0493505232517265 miRNAWalker2_validate -0.282384987183907 0.000225808008124877 NA NA NA hsa-miR-320a SNTB1 0.325285936317332 0.0221415065838824 -0.293060521048924 0.0493505232517265 MirTarget;miRanda;miRNATAP -0.132034641891436 0.00996639733903733 NA NA NA hsa-miR-320b SNTB1 0.0919652022571331 0.607981643616945 -0.293060521048924 0.0493505232517265 MirTarget;miRanda;miRNATAP -0.143551947367343 0.000424334009050608 NA NA NA hsa-miR-330-5p SNTB1 0.442231058604099 0.0053308560843808 -0.293060521048924 0.0493505232517265 miRanda -0.200411463270772 1.02040316214216e-05 NA NA NA hsa-miR-450b-5p SNTB1 -1.34333360369432 2.68386079790462e-17 -0.293060521048924 0.0493505232517265 mirMAP -0.163986811498928 0.000184788055278133 NA NA NA hsa-miR-192-5p SPARC -0.50188499512787 0.00344713341196035 0.718137488173 6.98854384110794e-07 miRNAWalker2_validate -0.376480630141672 1.70979260364267e-21 NA NA NA hsa-miR-28-5p SPARC -0.430964830599964 2.67367257252925e-06 0.718137488173 6.98854384110794e-07 miRanda -0.352004638560365 5.23950040745663e-06 NA NA NA hsa-miR-345-5p SPARC -0.712725883885838 3.60393522979373e-06 0.718137488173 6.98854384110794e-07 MirTarget -0.18253018867114 6.70116952798794e-05 NA NA NA hsa-miR-361-5p SPARC 0.233202959858696 0.00961572812255327 0.718137488173 6.98854384110794e-07 MirTarget -0.280990677713244 0.000441516665558438 NA NA NA hsa-miR-455-5p SPARC -0.270546034117157 0.0581320703577731 0.718137488173 6.98854384110794e-07 miRanda -0.229838430645835 3.82495469501829e-06 NA NA NA hsa-miR-532-3p SPARC 0.297601533259956 0.014632205884815 0.718137488173 6.98854384110794e-07 miRNATAP -0.251686071440364 1.64995664979602e-05 NA NA NA hsa-miR-7-1-3p SPARC -0.569105143287799 1.85297665041424e-05 0.718137488173 6.98854384110794e-07 mirMAP -0.197985422016039 0.000201516376931699 NA NA NA hsa-let-7f-1-3p SPOCK1 -0.704017923073338 7.84883628944999e-07 2.53504187150893 2.13962835594159e-10 mirMAP -0.389254175621422 0.00549461447489778 NA NA NA hsa-miR-139-5p SPOCK1 -2.11299531796557 8.16407076415038e-28 2.53504187150893 2.13962835594159e-10 PITA;miRanda;miRNATAP -0.423708309902778 9.21932166732659e-06 NA NA NA hsa-miR-148a-5p SPOCK1 -0.767626696027761 1.08359477494797e-06 2.53504187150893 2.13962835594159e-10 mirMAP -0.637315071847255 2.59258456535903e-07 NA NA NA hsa-miR-16-1-3p SPOCK1 0.392360028038559 0.00112481918108198 2.53504187150893 2.13962835594159e-10 MirTarget -0.670412480802202 4.6419582399762e-05 NA NA NA hsa-miR-193a-5p SPOCK1 -0.472805720224262 1.24962968905481e-05 2.53504187150893 2.13962835594159e-10 TargetScan -0.850569507092262 3.00552318309856e-06 NA NA NA hsa-miR-22-3p SPOCK1 -0.628561621952407 1.33755558015523e-09 2.53504187150893 2.13962835594159e-10 MirTarget -0.502709529958961 0.00813878591210886 NA NA NA hsa-miR-23b-3p SPOCK1 -0.530561587109023 5.43807206823652e-07 2.53504187150893 2.13962835594159e-10 MirTarget;miRNATAP -0.913107395839112 8.28673724511315e-07 NA NA NA hsa-miR-23b-5p SPOCK1 -1.05289229952702 7.22203199173865e-13 2.53504187150893 2.13962835594159e-10 MirTarget -0.419505974067867 0.00188970828131405 NA NA NA hsa-miR-26b-5p SPOCK1 -1.10804856399744 4.14176110314282e-22 2.53504187150893 2.13962835594159e-10 mirMAP -0.470793238366229 0.00449494857384248 NA NA NA hsa-miR-30e-3p SPOCK1 -1.20845647373031 3.10263633528203e-25 2.53504187150893 2.13962835594159e-10 mirMAP -0.763556683776641 1.9091790783751e-06 NA NA NA hsa-miR-326 SPOCK1 -1.881935132554 1.68087316863775e-21 2.53504187150893 2.13962835594159e-10 MirTarget;miRanda -0.251199613546319 0.00937584182843573 NA NA NA hsa-miR-33a-3p SPOCK1 -0.683025859637737 1.01106097756419e-05 2.53504187150893 2.13962835594159e-10 mirMAP -0.696157532162998 3.39917341922114e-08 NA NA NA hsa-miR-618 SPOCK1 0.13539895350352 0.517145913114103 2.53504187150893 2.13962835594159e-10 mirMAP -0.307467326132823 0.00182438962111834 NA NA NA hsa-miR-139-5p SPP1 -2.11299531796557 8.16407076415038e-28 1.86706198200398 0.000286687598509149 miRanda -1.1519772014133 2.46405732226498e-23 NA NA NA hsa-miR-335-5p SPP1 -1.61347836513558 1.62757083289711e-19 1.86706198200398 0.000286687598509149 miRNAWalker2_validate -0.389183181212584 0.00397841832397725 NA NA NA hsa-miR-128-3p TAGLN 0.289735108018712 0.0114419474207889 -0.544478436092708 0.00374485748665796 miRNAWalker2_validate -0.448600257114665 1.60538409464674e-08 NA NA NA hsa-miR-20a-5p TFPI2 0.854326758727003 5.04256669663285e-07 -2.98724706930921 5.09535819315938e-23 miRNATAP -0.494670789290977 3.07715671804473e-08 NA NA NA hsa-miR-139-5p TGFB1 -2.11299531796557 8.16407076415038e-28 0.0791820105139553 0.6886056388594 miRanda -0.165335310650966 0.000359864512900183 NA NA NA hsa-miR-16-5p TGFBI -0.398577235179603 0.000101598495180191 0.199277943085948 0.186119980175961 miRNAWalker2_validate -0.225605846418038 0.00162909326110127 NA NA NA hsa-let-7d-5p TGFBR3 0.0503292020123807 0.702580311853671 -1.53475612080717 2.32211754233392e-15 MirTarget -0.196855178961592 0.0084014005097078 NA NA NA hsa-miR-103a-3p TGFBR3 0.765568928457606 3.05497476509383e-12 -1.53475612080717 2.32211754233392e-15 MirTarget;miRNATAP -0.516178135225821 1.8918636364374e-09 NA NA NA hsa-miR-181a-5p TGFBR3 0.250113435902954 0.0551933249319293 -1.53475612080717 2.32211754233392e-15 miRNAWalker2_validate;mirMAP;miRNATAP -0.389031034293981 1.71466140133219e-07 NA NA NA hsa-miR-181b-5p TGFBR3 0.488256489401108 0.00105321129419701 -1.53475612080717 2.32211754233392e-15 mirMAP -0.467119604365662 2.30736536364399e-13 NA NA NA hsa-miR-181c-5p TGFBR3 -0.00639394152050299 0.969127212255928 -1.53475612080717 2.32211754233392e-15 mirMAP;miRNATAP -0.216998335317529 0.000246546877454723 NA NA NA hsa-miR-182-5p TGFBR3 1.96601340710222 4.39326175603633e-09 -1.53475612080717 2.32211754233392e-15 miRNATAP -0.183612681218707 5.45847960443815e-11 NA NA NA hsa-miR-18a-5p TGFBR3 0.918028187958706 1.90229510425322e-05 -1.53475612080717 2.32211754233392e-15 MirTarget -0.355232234366897 3.59550252157977e-16 NA NA NA hsa-miR-21-5p TGFBR3 1.51084295924322 1.54551622173259e-34 -1.53475612080717 2.32211754233392e-15 miRNAWalker2_validate -0.700530304569563 4.67202507056358e-24 NA NA NA hsa-miR-222-5p TGFBR3 0.125716360553359 0.487423909991138 -1.53475612080717 2.32211754233392e-15 MirTarget -0.326222351264924 9.58868656812027e-10 NA NA NA hsa-miR-30d-5p TGFBR3 0.718283816348023 2.47422074061352e-08 -1.53475612080717 2.32211754233392e-15 mirMAP -0.341148711785332 4.54804473299737e-06 NA NA NA hsa-miR-335-3p TGFBR3 -0.275199247483111 0.106629165248783 -1.53475612080717 2.32211754233392e-15 mirMAP -0.159138659572769 0.0055865810210199 NA NA NA hsa-miR-338-3p TGFBR3 0.543135607704581 0.00461167747143826 -1.53475612080717 2.32211754233392e-15 miRanda -0.27955763129368 2.51562122970982e-08 NA NA NA hsa-miR-339-5p TGFBR3 0.280589919878422 0.0355660282647215 -1.53475612080717 2.32211754233392e-15 miRanda -0.331241307788205 5.60177000922454e-06 NA NA NA hsa-miR-423-5p TGFBR3 0.698807775906485 1.02195196334612e-11 -1.53475612080717 2.32211754233392e-15 MirTarget -0.36733348375029 8.14314564275236e-05 NA NA NA hsa-miR-429 TGFBR3 -1.40262535827285 6.93982219171912e-05 -1.53475612080717 2.32211754233392e-15 miRanda -0.126701063796612 4.47504894450001e-06 NA NA NA hsa-miR-501-3p TGFBR3 0.999540908940094 2.77358485581974e-11 -1.53475612080717 2.32211754233392e-15 TargetScan;miRNATAP -0.387404581581371 6.00332430720371e-10 NA NA NA hsa-miR-589-3p TGFBR3 1.16846704028095 5.88525574424201e-11 -1.53475612080717 2.32211754233392e-15 MirTarget -0.333449671175673 5.53850221641506e-10 NA NA NA hsa-miR-106b-5p TGM2 0.648901865047099 8.24870862047885e-09 -0.875329681872056 2.87786913171852e-06 MirTarget -0.508850556252865 1.48056995941865e-10 NA NA NA hsa-miR-17-5p TGM2 0.698861147045461 2.43854106455398e-05 -0.875329681872056 2.87786913171852e-06 MirTarget -0.184977384225074 0.000796784858219907 NA NA NA hsa-miR-20a-5p TGM2 0.854326758727003 5.04256669663285e-07 -0.875329681872056 2.87786913171852e-06 MirTarget -0.235089408184339 9.91861947467251e-06 NA NA NA hsa-miR-324-3p TGM2 0.260348469146494 0.0506141704203545 -0.875329681872056 2.87786913171852e-06 MirTarget -0.198262155114549 0.00431543280319014 NA NA NA hsa-miR-34a-5p TGM2 1.03694231790865 5.74864019540594e-14 -0.875329681872056 2.87786913171852e-06 miRNAWalker2_validate -0.18393836971424 0.00462220257161869 NA NA NA hsa-miR-93-5p TGM2 1.39518349670953 2.84167728726712e-25 -0.875329681872056 2.87786913171852e-06 MirTarget -0.427053653716567 1.58294510906167e-11 NA NA NA hsa-miR-16-1-3p THBS1 0.392360028038559 0.00112481918108198 -2.1667874641621 3.47909831637717e-17 MirTarget -0.349993916076067 0.00122857732566393 NA NA NA hsa-miR-17-5p THBS1 0.698861147045461 2.43854106455398e-05 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.222517583477087 0.00443051973072606 NA NA NA hsa-miR-19a-3p THBS1 1.01712596153672 2.57753201450625e-07 -2.1667874641621 3.47909831637717e-17 MirTarget;mirMAP -0.266530076936376 3.91252800717626e-05 NA NA NA hsa-miR-19b-3p THBS1 0.601279551368824 0.00016685097085251 -2.1667874641621 3.47909831637717e-17 MirTarget;mirMAP -0.258570375211438 0.00144531729895803 NA NA NA hsa-miR-20a-5p THBS1 0.854326758727003 5.04256669663285e-07 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.298190202548282 7.75927048516442e-05 NA NA NA hsa-miR-32-5p THBS1 0.0806126674664016 0.548984992497432 -2.1667874641621 3.47909831637717e-17 mirMAP -0.415642500380362 1.79938285205236e-05 NA NA NA hsa-miR-589-3p THBS1 1.16846704028095 5.88525574424201e-11 -2.1667874641621 3.47909831637717e-17 mirMAP -0.207376170994383 0.00450904846984429 NA NA NA hsa-miR-616-5p THBS1 0.150569904638223 0.402836556304524 -2.1667874641621 3.47909831637717e-17 mirMAP -0.380879712809061 1.2036408171943e-07 NA NA NA hsa-miR-618 THBS1 0.13539895350352 0.517145913114103 -2.1667874641621 3.47909831637717e-17 MirTarget;PITA -0.212645935824045 0.000996351251570771 NA NA NA hsa-miR-92a-3p THBS1 0.212391012518195 0.134292268089997 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.25627633804456 0.00550821085297264 NA NA NA hsa-miR-106b-5p THBS2 0.648901865047099 8.24870862047885e-09 -0.502816786435579 0.158172197533798 MirTarget -0.486129671276457 0.00142005744712669 NA NA NA hsa-miR-17-5p THBS2 0.698861147045461 2.43854106455398e-05 -0.502816786435579 0.158172197533798 MirTarget;TargetScan -0.379943541096311 0.0002503795908654 NA NA NA hsa-miR-20a-5p THBS2 0.854326758727003 5.04256669663285e-07 -0.502816786435579 0.158172197533798 MirTarget -0.441793484244088 1.04186713814831e-05 NA NA NA hsa-miR-32-3p THBS2 0.219109440121582 0.207217051619543 -0.502816786435579 0.158172197533798 miRNATAP -0.641167195268276 2.66066595937387e-10 NA NA NA hsa-miR-590-5p THBS2 -0.103355559980404 0.310027295317092 -0.502816786435579 0.158172197533798 miRanda -0.711273245527382 3.36369868701585e-05 NA NA NA hsa-miR-7-1-3p THBS2 -0.569105143287799 1.85297665041424e-05 -0.502816786435579 0.158172197533798 MirTarget;mirMAP -0.343348786927578 0.00830467804380644 NA NA NA hsa-miR-93-5p THBS2 1.39518349670953 2.84167728726712e-25 -0.502816786435579 0.158172197533798 MirTarget -0.59037311789499 1.04093973646049e-06 NA NA NA hsa-miR-204-5p THY1 -0.537962150012103 0.0330895493358849 2.72289231338773 3.54708129756887e-45 mirMAP -0.198511869161557 1.52455455327579e-06 NA NA NA hsa-miR-361-5p TIMP1 0.233202959858696 0.00961572812255327 -0.36500897482577 0.201445733959009 miRanda -0.828605711361376 8.02611560081037e-08 NA NA NA hsa-miR-103a-3p TIMP3 0.765568928457606 3.05497476509383e-12 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase -0.19444070066562 0.00106458729135409 22783422 miR-103 inhibitor transfection increased the activity of the luciferase reporter assay containing the TIMP-3 3'-untranslated region UTR construct and increased the levels of the TIMP-3 protein but not its mRNA in endometrial cancer cell lines; Our data suggested that miR-103 post-transcriptionally downregulates the expression of the tumor suppressor TIMP-3 and stimulates growth and invasion in endometrial cancer cell lines endometrial cancer hsa-miR-106a-5p TIMP3 -0.464229535269236 0.009724944358047 -0.479569227754572 0.00042274706056242 miRNATAP -0.13431453592961 0.000274619257643012 NA NA NA hsa-miR-106b-5p TIMP3 0.648901865047099 8.24870862047885e-09 -0.479569227754572 0.00042274706056242 miRNATAP -0.518964265088086 1.57351137224809e-20 NA NA NA hsa-miR-16-1-3p TIMP3 0.392360028038559 0.00112481918108198 -0.479569227754572 0.00042274706056242 mirMAP -0.193778851890265 0.000449465531741991 NA NA NA hsa-miR-16-5p TIMP3 -0.398577235179603 0.000101598495180191 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate -0.238801022352312 0.00023236060732765 NA NA NA hsa-miR-181b-5p TIMP3 0.488256489401108 0.00105321129419701 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118880966586347 0.0077111895916643 27383203 Moreover miR-181b was found to directly target the 3' untranslated region 3'UTR of Timp3 mRNA affecting TGF-β-induced EMT gastric cancer hsa-miR-188-5p TIMP3 1.11646899351496 9.56686958408598e-11 -0.479569227754572 0.00042274706056242 mirMAP -0.136027474478049 0.000315224827308733 NA NA NA hsa-miR-20a-5p TIMP3 0.854326758727003 5.04256669663285e-07 -0.479569227754572 0.00042274706056242 miRNATAP -0.209156104661086 4.35176096892657e-08 NA NA NA hsa-miR-21-5p TIMP3 1.51084295924322 1.54551622173259e-34 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.285668268989237 5.87344757554495e-09 25720799;23936642;21820586;20346171;25587717 We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;progression;metastasis;tumorigenesis;poor survival;tumorigenesis; liver cancer;breast cancer;kidney renal cell cancer;breast cancer;melanoma hsa-miR-221-3p TIMP3 1.12244756358612 3.48370308238012e-13 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144635283598806 0.000555681773778346 27077469 MiR 221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma; The results indicated that miR-221 exacerbated PTC by downregulating the expression of TIMP3; The effects of miR-221 and TIMP3 in vivo were also confirmed by human PTC-bearing mice models which suggest consistent results with those in vitro studies thyroid cancer hsa-miR-222-3p TIMP3 1.08574156066353 1.76407192348131e-11 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196480024645766 8.49146596783842e-07 NA NA NA hsa-miR-30d-5p TIMP3 0.718283816348023 2.47422074061352e-08 -0.479569227754572 0.00042274706056242 miRNATAP -0.13615001554207 0.00770987605233984 NA NA NA hsa-miR-3200-3p TIMP3 1.40312896232918 1.8232142177606e-07 -0.479569227754572 0.00042274706056242 mirMAP -0.14880356028367 3.18925670305246e-09 NA NA NA hsa-miR-423-5p TIMP3 0.698807775906485 1.02195196334612e-11 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate -0.326353716171156 2.28064057362927e-07 NA NA NA hsa-miR-452-5p TIMP3 1.91544498799508 1.81995982853313e-14 -0.479569227754572 0.00042274706056242 MirTarget;miRNATAP -0.109172559730824 1.98937022133239e-05 NA NA NA hsa-miR-589-3p TIMP3 1.16846704028095 5.88525574424201e-11 -0.479569227754572 0.00042274706056242 mirMAP -0.193391306480792 1.53208161144194e-07 NA NA NA hsa-miR-590-5p TIMP3 -0.103355559980404 0.310027295317092 -0.479569227754572 0.00042274706056242 MirTarget;PITA;miRanda;miRNATAP -0.357646258304178 4.27464833810944e-08 NA NA NA hsa-miR-365a-3p TNC 0.164591326307714 0.15325084963213 -0.741405240029029 0.00843299261104527 MirTarget -0.507909356836929 2.14253613517559e-05 NA NA NA hsa-miR-107 TPM1 0.241662461253461 0.0170788899505389 0.526938630465131 3.3213429931344e-05 PITA;miRanda -0.171237380974886 0.00577099047668392 NA NA NA hsa-miR-33a-3p TPM1 -0.683025859637737 1.01106097756419e-05 0.526938630465131 3.3213429931344e-05 miRNATAP -0.161772481157121 4.85985689498559e-05 NA NA NA hsa-miR-590-3p TPM1 -0.473167498047808 1.76652934637227e-05 0.526938630465131 3.3213429931344e-05 miRanda -0.2150361761897 0.00013109365883788 NA NA NA hsa-miR-192-5p TPM4 -0.50188499512787 0.00344713341196035 0.3605306383464 0.00979481452100365 miRNAWalker2_validate -0.441147882156579 1.54587215893729e-33 NA NA NA hsa-miR-28-5p TPM4 -0.430964830599964 2.67367257252925e-06 0.3605306383464 0.00979481452100365 miRNAWalker2_validate -0.404542044109431 3.40815034022066e-08 NA NA NA hsa-miR-101-3p VCAN -1.48176407980989 3.98950707385704e-31 0.3467634039065 0.320202578720279 miRNATAP -0.683578145591999 2.13971948153848e-08 NA NA NA hsa-miR-107 VCAN 0.241662461253461 0.0170788899505389 0.3467634039065 0.320202578720279 MirTarget;miRanda;miRNATAP -1.26476393171151 1.2442980965756e-14 NA NA NA hsa-miR-144-3p VCAN -2.97536914478815 6.00546047309683e-28 0.3467634039065 0.320202578720279 miRNATAP -0.171784534241824 0.00323687285143018 NA NA NA hsa-miR-186-5p VCAN -0.060103391373687 0.535288717081205 0.3467634039065 0.320202578720279 MirTarget;miRNATAP -0.504099426287538 0.00451436658573109 NA NA NA hsa-miR-23b-3p VCAN -0.530561587109023 5.43807206823652e-07 0.3467634039065 0.320202578720279 MirTarget;miRNATAP -0.797326247216568 4.55246092443194e-07 NA NA NA hsa-miR-28-5p VCAN -0.430964830599964 2.67367257252925e-06 0.3467634039065 0.320202578720279 miRanda -0.947917977442218 2.31244534913207e-07 NA NA NA hsa-miR-33a-3p VCAN -0.683025859637737 1.01106097756419e-05 0.3467634039065 0.320202578720279 mirMAP -0.569105417023009 1.3133785632486e-07 NA NA NA hsa-miR-33a-5p VCAN -0.767474460958522 1.09948756118522e-05 0.3467634039065 0.320202578720279 MirTarget -0.333619524331835 0.000528179506028384 NA NA NA hsa-miR-455-5p VCAN -0.270546034117157 0.0581320703577731 0.3467634039065 0.320202578720279 miRanda;miRNATAP -0.658824889693079 2.16486973028201e-08 NA NA NA hsa-miR-150-5p VEGFA -1.14624309254329 1.51365525978726e-06 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase -0.114666527453602 2.4663414134099e-07 NA NA NA hsa-miR-29b-2-5p VEGFA -0.223258653034772 0.084306146519938 0.0263183839451075 0.81382635000524 MirTarget -0.132006150652748 0.00171675395806506 NA NA NA hsa-miR-29b-3p VEGFA -0.348885528720517 0.0121441341291285 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase;MirTarget -0.125790856471025 0.00126089778683366 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-128-3p VEGFC 0.289735108018712 0.0114419474207889 0.0031169028254141 0.982787493023474 miRNAWalker2_validate;MirTarget -0.198618366596319 0.00124097531466772 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC -0.0336420826463706 0.805158952566973 0.0031169028254141 0.982787493023474 MirTarget -0.149514000508957 0.00387572506927192 NA NA NA hsa-miR-374a-5p VEGFC 0.016390363747302 0.869784217438621 0.0031169028254141 0.982787493023474 MirTarget -0.28522635078723 5.53265846690998e-05 NA NA NA hsa-miR-374b-5p VEGFC -0.307538028546424 0.0030079617545972 0.0031169028254141 0.982787493023474 MirTarget -0.209454919974677 0.00209421071373184 NA NA NA hsa-miR-590-3p VEGFC -0.473167498047808 1.76652934637227e-05 0.0031169028254141 0.982787493023474 miRanda -0.274821384359749 1.36978001441178e-05 NA NA NA hsa-miR-26b-5p VIM -1.10804856399744 4.14176110314282e-22 0.238035988962227 0.0725461526598976 miRNAWalker2_validate -0.154224184534623 0.00409806887752295 24890815 Increased expression of miR-26b inhibited the migration and invasiveness of HCC cell lines which was accompanied by decreased expression of the epithelial marker E-cadherin and increased expression of the mesenchymal marker vimentin at both the mRNA and protein expression levels liver cancer hsa-miR-590-3p VIM -0.473167498047808 1.76652934637227e-05 0.238035988962227 0.0725461526598976 mirMAP -0.169986414889446 0.0036302899099973 NA NA NA hsa-miR-590-5p VIM -0.103355559980404 0.310027295317092 0.238035988962227 0.0725461526598976 PITA;miRanda;miRNATAP -0.209181756891018 0.00107864794691168 NA NA NA hsa-miR-30d-5p WIPF1 0.718283816348023 2.47422074061352e-08 -0.563235550962353 0.00037095694490736 MirTarget;miRNATAP -0.220506885688549 0.000196990954574251 NA NA NA hsa-miR-33a-3p WIPF1 -0.683025859637737 1.01106097756419e-05 -0.563235550962353 0.00037095694490736 MirTarget -0.184996528225265 0.000192081859886901 NA NA NA hsa-miR-361-5p WIPF1 0.233202959858696 0.00961572812255327 -0.563235550962353 0.00037095694490736 miRanda -0.272241348893108 0.00174200167049996 NA NA NA hsa-miR-618 WIPF1 0.13539895350352 0.517145913114103 -0.563235550962353 0.00037095694490736 MirTarget;PITA;miRNATAP -0.190221601754005 5.81066592938823e-07 NA NA NA hsa-miR-624-5p WIPF1 -0.639533773668123 6.79146620944254e-06 -0.563235550962353 0.00037095694490736 MirTarget -0.148023845670922 0.00628724158434678 NA NA NA hsa-miR-664a-3p WIPF1 0.485807855553031 0.000732553249798598 -0.563235550962353 0.00037095694490736 MirTarget -0.186451120535705 0.000509630912123489 NA NA NA hsa-miR-664a-5p WIPF1 -0.0738022124558593 0.597681758599428 -0.563235550962353 0.00037095694490736 MirTarget -0.209437094760457 0.000160962806708008 NA NA NA hsa-miR-375 WNT5A -1.93190458972328 4.28108492522e-06 -0.379867591757487 0.265970692489084 miRNATAP -0.114882013104506 0.00325292733019044 NA NA NA