miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-let-7g-5p CBL 1.20061455355116 1.50237505511483e-12 -0.309132961135003 0.0648412067348561 MirTarget -0.106316019893588 0.0241069397535424 NA NA NA hsa-miR-200c-3p CBL 3.50132673580082 2.42716349086937e-15 -0.309132961135003 0.0648412067348561 MirTarget;mirMAP -0.105782323761434 1.02635974205051e-09 NA NA NA hsa-miR-21-5p CBL 2.73773305747971 1.38864982139576e-43 -0.309132961135003 0.0648412067348561 mirMAP -0.108902418098683 0.00327704154317381 NA NA NA hsa-miR-22-3p CBL 1.21545661147757 1.61670170137775e-13 -0.309132961135003 0.0648412067348561 MirTarget -0.123015155972491 0.0111174377942772 NA NA NA hsa-miR-29c-3p CBL -0.00968972577705429 0.97099586346872 -0.309132961135003 0.0648412067348561 mirMAP -0.107546106413961 0.000406475207651119 NA NA NA hsa-miR-320a CBL 0.438165828017084 0.0390159073347133 -0.309132961135003 0.0648412067348561 miRNATAP -0.145137866983655 0.000146813694967592 NA NA NA hsa-miR-664a-3p CBL 0.634721925861133 0.00520070178640421 -0.309132961135003 0.0648412067348561 mirMAP -0.200350156890025 1.28165895812933e-08 NA NA NA hsa-miR-98-5p CBL 1.11154309866014 1.24143909012085e-08 -0.309132961135003 0.0648412067348561 MirTarget -0.104888431416319 0.01085000953087 NA NA NA hsa-miR-590-3p CBLB 2.59289455139753 1.03200520972022e-21 -0.413700369417769 0.011359940260198 miRanda -0.110161206832092 0.000108480730925665 NA NA NA hsa-let-7i-5p CCND1 0.412877696970403 0.00622731051981756 0.0828319966762319 0.840332435689448 miRNATAP -0.284438698944636 0.0343513165460748 NA NA NA hsa-miR-106a-5p CCND1 2.48882002962836 1.99757727374521e-12 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.278915751904438 2.46069960202024e-07 NA NA NA hsa-miR-106b-5p CCND1 2.46782146831112 1.36171495805632e-23 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.190269381519641 0.0130099591661973 NA NA NA hsa-miR-1266-5p CCND1 1.3763848124288 0.000876906064212958 0.0828319966762319 0.840332435689448 MirTarget -0.105015097102923 0.0290668649868883 NA NA NA hsa-miR-15b-5p CCND1 1.57112623124278 9.14247846750597e-13 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.2743592470705 0.00190316455907807 NA NA NA hsa-miR-186-5p CCND1 1.47445398888668 3.0781726595413e-15 0.0828319966762319 0.840332435689448 mirMAP -0.319993507741074 0.0020448551843367 NA NA NA hsa-miR-193a-3p CCND1 1.60460546928078 2.86169793322984e-07 0.0828319966762319 0.840332435689448 MirTarget;PITA;miRanda -0.351734964348069 1.30056584701733e-08 NA NA NA hsa-miR-195-5p CCND1 -1.44753678070504 8.70594292149271e-09 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.232938095379387 0.00278406868271715 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-19a-3p CCND1 3.42309334186656 3.02671914353412e-28 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;miRNATAP -0.129855568478024 0.0302697285085785 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 2.57951428759379 4.31576118703427e-20 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase -0.152456226657987 0.0285260627618516 NA NA NA hsa-miR-19b-3p CCND1 2.49529833021187 1.57028265846699e-23 0.0828319966762319 0.840332435689448 miRNATAP -0.175038387630043 0.0207556361843719 NA NA NA hsa-miR-20b-5p CCND1 2.07706563022469 1.10107236083433e-05 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.250774310314038 8.20956147612201e-10 NA NA NA hsa-miR-338-3p CCND1 0.453166438193782 0.144583389707558 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase;miRanda -0.14528834655399 0.0235908904377559 NA NA NA hsa-miR-340-5p CCND1 0.30282999308409 0.157744789519131 0.0828319966762319 0.840332435689448 mirMAP -0.529085780655826 9.29072904979919e-09 NA NA NA hsa-miR-365a-3p CCND1 -0.0388985816963467 0.859114494267351 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;miRTarBase -0.20916008203635 0.0224869632381042 NA NA NA hsa-miR-374b-5p CCND1 0.0654362503857184 0.722673188879465 0.0828319966762319 0.840332435689448 miRNAWalker2_validate;MirTarget -0.416222074203323 0.000132219455740898 NA NA NA hsa-miR-497-5p CCND1 0.0257087130056286 0.918145413833358 0.0828319966762319 0.840332435689448 MirTarget;miRNATAP -0.30773442281542 0.000110601843767413 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-589-3p CCND1 2.51971841868825 2.39125940264107e-11 0.0828319966762319 0.840332435689448 MirTarget -0.144538788730598 0.0136645647437734 NA NA NA hsa-miR-7-1-3p CCND1 1.84950311431067 1.25300363397654e-13 0.0828319966762319 0.840332435689448 mirMAP -0.247700635127977 0.00138754391814163 NA NA NA hsa-miR-769-3p CCND1 2.19896922202687 5.69250370895053e-12 0.0828319966762319 0.840332435689448 mirMAP -0.231146561837838 0.000210475786569237 NA NA NA hsa-miR-92a-3p CCND1 2.06460102658973 1.44784291084757e-19 0.0828319966762319 0.840332435689448 miRNAWalker2_validate -0.18696336621808 0.0257330648039561 NA NA NA hsa-let-7a-3p CCND2 1.42015538786275 7.03375209382654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.440555668621489 2.14967330798537e-06 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7a-5p CCND2 0.618599506841644 2.76973453058748e-05 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.503238938401113 9.92586197811674e-05 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 prostate cancer hsa-let-7b-3p CCND2 0.868207752019623 1.30460056774366e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.292600423696445 0.00203496813099611 NA NA NA hsa-let-7b-5p CCND2 0.604314269683977 0.00140009936153214 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372644945722985 0.000202758514128247 NA NA NA hsa-let-7e-5p CCND2 0.860104282510173 6.04758298373779e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.254279031336757 0.00390630067355032 NA NA NA hsa-let-7f-1-3p CCND2 1.55054488387679 7.31326775537952e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.349075249109793 1.19776506071246e-05 NA NA NA hsa-let-7f-5p CCND2 0.495648727272215 0.00355972741198794 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.395067035409999 0.000431247614557398 NA NA NA hsa-let-7g-5p CCND2 1.20061455355116 1.50237505511483e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.78482657734201 2.2934101130382e-13 NA NA NA hsa-miR-106a-5p CCND2 2.48882002962836 1.99757727374521e-12 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.460265785003224 1.90572227650597e-20 NA NA NA hsa-miR-106b-5p CCND2 2.46782146831112 1.36171495805632e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.723802321113981 4.62852843641777e-26 NA NA NA hsa-miR-10b-3p CCND2 0.77597971642517 0.00264877454133753 -2.42747067684236 2.06814828958882e-10 mirMAP -0.299055149155965 4.03151748542262e-05 NA NA NA hsa-miR-130b-5p CCND2 2.9963110846538 1.98883029416455e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524276006004661 2.15252650149472e-24 NA NA NA hsa-miR-141-3p CCND2 5.02396127982626 2.19224509139725e-24 -2.42747067684236 2.06814828958882e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-151a-3p CCND2 1.24018761527407 1.08839919675408e-07 -2.42747067684236 2.06814828958882e-10 mirMAP -0.618872158164273 1.57062556462901e-15 NA NA NA hsa-miR-15a-5p CCND2 2.34669284378787 1.69544424500258e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.558385276567589 5.78612617845985e-14 NA NA NA hsa-miR-15b-5p CCND2 1.57112623124278 9.14247846750597e-13 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.814047353716774 1.36644748676197e-24 NA NA NA hsa-miR-16-2-3p CCND2 2.31623086727196 4.29838149388188e-20 -2.42747067684236 2.06814828958882e-10 mirMAP -0.524415153934827 5.42085565840902e-14 NA NA NA hsa-miR-16-5p CCND2 1.75824877145857 1.68592440033108e-16 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRNATAP -0.624880555696101 7.5948593080299e-14 NA NA NA hsa-miR-17-5p CCND2 3.2710598467455 9.93128340539455e-27 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.576586035201243 5.39762569803648e-26 NA NA NA hsa-miR-181a-2-3p CCND2 2.19062681262366 3.81790102612782e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.371385706331271 5.48097191184985e-10 NA NA NA hsa-miR-182-5p CCND2 3.53923166221814 5.07781258121574e-21 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.418107303561313 5.83833309647385e-20 NA NA NA hsa-miR-183-5p CCND2 4.19757025992371 4.79612296318304e-26 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.406097602561121 1.1832385157764e-21 NA NA NA hsa-miR-185-5p CCND2 2.34016206907488 1.17481626642022e-26 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.596214855521239 5.09732672184216e-14 NA NA NA hsa-miR-186-5p CCND2 1.47445398888668 3.0781726595413e-15 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.753228825405404 3.55444659312987e-15 NA NA NA hsa-miR-188-5p CCND2 2.52825126596644 6.78099435999778e-14 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.327199573697285 9.78244941189197e-09 NA NA NA hsa-miR-191-5p CCND2 2.30038190670664 9.93191704545938e-17 -2.42747067684236 2.06814828958882e-10 MirTarget -0.63056469865633 4.58280529094783e-24 NA NA NA hsa-miR-19a-3p CCND2 3.42309334186656 3.02671914353412e-28 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.478555105133488 2.03415225430867e-18 NA NA NA hsa-miR-19b-3p CCND2 2.49529833021187 1.57028265846699e-23 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.644240893236217 5.93065810659583e-21 NA NA NA hsa-miR-200a-3p CCND2 4.59434485520731 6.38952518573476e-18 -2.42747067684236 2.06814828958882e-10 MirTarget -0.322639326506763 1.12744821991113e-23 NA NA NA hsa-miR-20a-5p CCND2 3.15577933619191 4.19753346442454e-25 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.552675029838617 1.98133209896024e-23 NA NA NA hsa-miR-20b-5p CCND2 2.07706563022469 1.10107236083433e-05 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.296015277168294 1.16933542500196e-14 NA NA NA hsa-miR-21-3p CCND2 2.19296355304364 4.63665722759779e-15 -2.42747067684236 2.06814828958882e-10 mirMAP -0.266420777851125 4.25531839718567e-05 NA NA NA hsa-miR-224-3p CCND2 1.87536386559317 6.15140969394846e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.234939524450716 1.27567539540633e-08 NA NA NA hsa-miR-26b-5p CCND2 0.885393662798425 3.2116297961629e-06 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.333191234288059 0.000785967313666436 NA NA NA hsa-miR-29b-3p CCND2 1.65828197923813 1.02676780888141e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.181452610770389 0.00800883535071036 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-301a-3p CCND2 2.81024345929638 2.29784847962242e-17 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.490714440601798 1.13987935585442e-18 NA NA NA hsa-miR-3065-3p CCND2 2.16221780121195 9.65525739884541e-09 -2.42747067684236 2.06814828958882e-10 MirTarget;miRNATAP -0.234083951058536 1.60505150894369e-06 NA NA NA hsa-miR-3065-5p CCND2 2.74629919868982 1.86846589298284e-08 -2.42747067684236 2.06814828958882e-10 mirMAP -0.236930159170796 2.73973057309239e-07 NA NA NA hsa-miR-30d-3p CCND2 0.977747550180601 4.3048212205381e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.514799428246913 2.69094766335815e-11 NA NA NA hsa-miR-30e-3p CCND2 -0.215663037684509 0.235375122783546 -2.42747067684236 2.06814828958882e-10 mirMAP -0.317748716556734 0.00256884077064715 NA NA NA hsa-miR-32-3p CCND2 2.02436999565685 5.94091197945307e-09 -2.42747067684236 2.06814828958882e-10 mirMAP -0.37065809204682 5.74913234109809e-10 NA NA NA hsa-miR-320a CCND2 0.438165828017084 0.0390159073347133 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.366959333753783 3.90012764364419e-05 NA NA NA hsa-miR-320b CCND2 1.55692969039548 1.41071034251915e-08 -2.42747067684236 2.06814828958882e-10 mirMAP;miRNATAP -0.389495451202309 5.62361965191887e-09 NA NA NA hsa-miR-324-3p CCND2 2.08739139768981 3.11885987067952e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.569926030100518 1.57078270718816e-20 NA NA NA hsa-miR-331-5p CCND2 2.17414714166315 1.54547681391888e-18 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.55418360999634 4.24751797285043e-14 NA NA NA hsa-miR-335-5p CCND2 1.77247705492746 2.22457658872091e-06 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.196309653133352 7.59470226154717e-05 NA NA NA hsa-miR-33a-3p CCND2 1.72765312072219 1.51784443453521e-07 -2.42747067684236 2.06814828958882e-10 MirTarget -0.474892003832155 3.60158523540778e-15 NA NA NA hsa-miR-3607-3p CCND2 2.68532138541128 5.66716351955047e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.253991708738003 1.1264040881505e-06 NA NA NA hsa-miR-374b-3p CCND2 0.930487774873495 2.74420094310516e-05 -2.42747067684236 2.06814828958882e-10 mirMAP -0.379294826109076 7.61411367904561e-06 NA NA NA hsa-miR-378a-3p CCND2 -0.10995720000828 0.716188270032681 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.264766627168263 2.14263562743039e-05 NA NA NA hsa-miR-423-5p CCND2 0.963563145758616 9.86109015204915e-07 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.681308347713645 2.78087673863117e-13 NA NA NA hsa-miR-424-5p CCND2 1.61930224569578 1.89642549274994e-10 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.208747216207423 0.00424259734488207 NA NA NA hsa-miR-429 CCND2 4.48815175680773 2.44117492218206e-17 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.316889169500172 1.77696184266368e-22 NA NA NA hsa-miR-450b-5p CCND2 1.69244418548325 1.68064054148881e-10 -2.42747067684236 2.06814828958882e-10 MirTarget;PITA;miRNATAP -0.299286922863212 1.69011727706147e-05 NA NA NA hsa-miR-500a-5p CCND2 1.72110365584658 3.0807246212659e-10 -2.42747067684236 2.06814828958882e-10 mirMAP -0.230284164405623 0.000679591942778451 NA NA NA hsa-miR-501-5p CCND2 1.93654809410041 1.3779381780759e-10 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP;miRNATAP -0.278516160908165 9.05358509837179e-06 NA NA NA hsa-miR-503-5p CCND2 3.66513190181895 6.60300917645278e-21 -2.42747067684236 2.06814828958882e-10 MirTarget -0.31264390956225 5.2815091282227e-11 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 2.11025227932763 6.94489556637146e-12 -2.42747067684236 2.06814828958882e-10 MirTarget -0.44540662591501 2.41152035101861e-14 NA NA NA hsa-miR-589-3p CCND2 2.51971841868825 2.39125940264107e-11 -2.42747067684236 2.06814828958882e-10 mirMAP -0.360588568041429 3.76015378643146e-11 NA NA NA hsa-miR-590-3p CCND2 2.59289455139753 1.03200520972022e-21 -2.42747067684236 2.06814828958882e-10 miRanda;mirMAP -0.419988530136573 3.79848108645639e-10 NA NA NA hsa-miR-590-5p CCND2 3.18300989862077 2.06813568597893e-26 -2.42747067684236 2.06814828958882e-10 mirMAP -0.50562344923364 6.73026539304424e-18 NA NA NA hsa-miR-660-5p CCND2 1.82692095272076 1.92040083607196e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.361636929774302 8.5078492819456e-07 NA NA NA hsa-miR-7-1-3p CCND2 1.84950311431067 1.25300363397654e-13 -2.42747067684236 2.06814828958882e-10 mirMAP -0.518854235917429 5.32697612805784e-13 NA NA NA hsa-miR-708-3p CCND2 2.80907765282502 3.07460722669281e-14 -2.42747067684236 2.06814828958882e-10 mirMAP -0.177604972093223 0.000316375213374722 NA NA NA hsa-miR-708-5p CCND2 3.38051631555486 5.12590198690777e-18 -2.42747067684236 2.06814828958882e-10 mirMAP -0.19367896307831 2.62089031491477e-05 NA NA NA hsa-miR-877-5p CCND2 2.94916202082736 1.8151927276044e-13 -2.42747067684236 2.06814828958882e-10 miRNAWalker2_validate -0.361363420346396 6.83899428438154e-13 NA NA NA hsa-miR-93-5p CCND2 3.03961860136032 1.11672209617395e-24 -2.42747067684236 2.06814828958882e-10 miRNATAP -0.640135233296746 3.73391346199191e-30 NA NA NA hsa-miR-944 CCND2 2.91186649218281 1.31574753528144e-06 -2.42747067684236 2.06814828958882e-10 PITA;mirMAP -0.168575408637895 9.32931241492905e-08 NA NA NA hsa-miR-96-5p CCND2 4.89433085814374 1.92000659886961e-31 -2.42747067684236 2.06814828958882e-10 TargetScan;miRNATAP -0.382951897231727 7.25785958201884e-21 NA NA NA hsa-miR-27b-3p CCND3 0.196007704287769 0.295630157035388 0.142518749044219 0.397307080616203 miRNAWalker2_validate -0.133645004740845 0.00231237621077374 NA NA NA hsa-miR-361-5p CISH 0.971859117235239 5.30236555707088e-09 0.066853973960272 0.771664675975181 miRanda -0.191093866919635 0.00414199976130481 NA NA NA hsa-miR-374a-3p CISH 0.533309330504947 0.00192918429705142 0.066853973960272 0.771664675975181 MirTarget -0.223962182928861 0.000598491211209638 NA NA NA hsa-miR-185-3p CLCF1 2.3922478518806 1.3373426768452e-14 -0.698809436030494 0.0579566566506321 MirTarget -0.120960355430615 0.0301026012507796 NA NA NA hsa-miR-30c-5p CLCF1 0.778774633108 0.000285599212429136 -0.698809436030494 0.0579566566506321 miRNATAP -0.326125179051052 8.407986666959e-05 NA NA NA hsa-miR-30d-5p CLCF1 0.675423997639582 0.00270618816039773 -0.698809436030494 0.0579566566506321 miRNATAP -0.499855304769248 1.44757627878031e-10 NA NA NA hsa-miR-421 CLCF1 1.17791565395543 6.78526676976629e-06 -0.698809436030494 0.0579566566506321 miRanda -0.162264758833419 0.0170188481296875 NA NA NA hsa-miR-429 CLCF1 4.48815175680773 2.44117492218206e-17 -0.698809436030494 0.0579566566506321 miRanda;miRNATAP -0.217454264583658 5.37973595890096e-12 NA NA NA hsa-miR-1976 CNTFR 2.06550563678192 7.81396978619772e-18 -3.85610534555259 4.26251450212736e-08 miRNATAP -0.554222624382347 6.21666958925755e-05 NA NA NA hsa-miR-200b-3p CNTFR 3.78235093249346 3.18343003239465e-14 -3.85610534555259 4.26251450212736e-08 TargetScan -0.286217733525535 1.7951590460361e-05 NA NA NA hsa-miR-200c-3p CNTFR 3.50132673580082 2.42716349086937e-15 -3.85610534555259 4.26251450212736e-08 miRNATAP -0.437014825669292 4.0789929368456e-09 NA NA NA hsa-miR-21-5p CNTFR 2.73773305747971 1.38864982139576e-43 -3.85610534555259 4.26251450212736e-08 miRNATAP -0.745467707954985 2.14736492373171e-06 NA NA NA hsa-miR-24-3p CNTFR 0.99989036772428 1.35595013650376e-07 -3.85610534555259 4.26251450212736e-08 miRNATAP -0.613801129405572 0.000723869791797189 NA NA NA hsa-miR-26b-5p CNTFR 0.885393662798425 3.2116297961629e-06 -3.85610534555259 4.26251450212736e-08 miRNAWalker2_validate -0.520986196447903 0.00423503940270374 NA NA NA hsa-miR-30b-3p CNTFR 0.834142820354026 0.000972582820878813 -3.85610534555259 4.26251450212736e-08 mirMAP -0.270333312971255 0.0499119166884043 NA NA NA hsa-miR-361-3p CNTFR 1.07367425434318 1.73142774168958e-09 -3.85610534555259 4.26251450212736e-08 PITA;miRNATAP -0.704476263197078 0.000250348626214003 NA NA NA hsa-miR-429 CNTFR 4.48815175680773 2.44117492218206e-17 -3.85610534555259 4.26251450212736e-08 PITA;miRanda;miRNATAP -0.276449439884692 8.77482733312842e-06 NA NA NA hsa-miR-484 CNTFR 1.81844463411787 1.82951571230938e-15 -3.85610534555259 4.26251450212736e-08 PITA;miRNATAP -0.369587523831436 0.0120622694001604 NA NA NA hsa-miR-590-5p CNTFR 3.18300989862077 2.06813568597893e-26 -3.85610534555259 4.26251450212736e-08 PITA;miRanda;miRNATAP -0.231839764171542 0.0384015031897199 NA NA NA hsa-miR-186-5p CREBBP 1.47445398888668 3.0781726595413e-15 -0.451040948976341 0.000687386434761364 mirMAP;miRNATAP -0.14581204925591 1.28616268232458e-05 NA NA NA hsa-miR-26b-5p CREBBP 0.885393662798425 3.2116297961629e-06 -0.451040948976341 0.000687386434761364 miRNATAP -0.128164022830949 0.000145104031692185 NA NA NA hsa-miR-125a-3p CSF2RA 1.24490295132072 5.26925231010328e-06 -0.4553523853558 0.336459148012398 miRanda -0.168864337098838 0.0430562220811156 NA NA NA hsa-miR-129-5p CSF2RA -0.524170159980738 0.222582956006346 -0.4553523853558 0.336459148012398 mirMAP -0.184762146282875 0.000655202573807057 NA NA NA hsa-miR-330-5p CSF2RA 1.15100069700871 4.85551805046014e-07 -0.4553523853558 0.336459148012398 miRanda -0.250267527777727 0.011953315853783 NA NA NA hsa-miR-361-5p CSF2RA 0.971859117235239 5.30236555707088e-09 -0.4553523853558 0.336459148012398 miRanda -0.99144303897371 1.15548302893588e-13 NA NA NA hsa-miR-429 CSF2RA 4.48815175680773 2.44117492218206e-17 -0.4553523853558 0.336459148012398 miRanda -0.316749360663251 2.98906853937265e-15 NA NA NA hsa-miR-590-3p CSF2RA 2.59289455139753 1.03200520972022e-21 -0.4553523853558 0.336459148012398 mirMAP -0.170659500979583 0.0397705881080091 NA NA NA hsa-miR-125a-5p CSF2RB 0.599529391575274 0.0102300147180307 -0.739086291347396 0.0696045958228138 miRanda -0.426358007692611 3.75324813924671e-07 NA NA NA hsa-miR-15b-3p CSF2RB 2.33847028227712 4.29662877950836e-19 -0.739086291347396 0.0696045958228138 mirMAP -0.410621118990345 8.08744457322504e-09 NA NA NA hsa-miR-181b-5p CSF2RB 2.49307679431293 3.92829250217627e-20 -0.739086291347396 0.0696045958228138 MirTarget -0.199878586632952 0.0040462000934792 NA NA NA hsa-miR-181c-5p CSF2RB 1.58587920618301 1.57506918816933e-10 -0.739086291347396 0.0696045958228138 MirTarget -0.192897492889798 0.0137082096418576 NA NA NA hsa-miR-181d-5p CSF2RB 1.52204912185579 9.2693319057748e-08 -0.739086291347396 0.0696045958228138 MirTarget -0.305318018697499 6.94331838017145e-06 NA NA NA hsa-miR-186-5p CSF2RB 1.47445398888668 3.0781726595413e-15 -0.739086291347396 0.0696045958228138 mirMAP -0.36439054422735 0.000394153164171476 NA NA NA hsa-miR-19a-3p CSF2RB 3.42309334186656 3.02671914353412e-28 -0.739086291347396 0.0696045958228138 MirTarget -0.217107868095224 0.00024429476771933 NA NA NA hsa-miR-19b-3p CSF2RB 2.49529833021187 1.57028265846699e-23 -0.739086291347396 0.0696045958228138 MirTarget -0.339753464615837 5.03583434435228e-06 NA NA NA hsa-miR-30b-3p CSF2RB 0.834142820354026 0.000972582820878813 -0.739086291347396 0.0696045958228138 MirTarget -0.473179222241933 7.9171965820414e-10 NA NA NA hsa-miR-452-3p CSF2RB 2.42521958420768 4.08754552781156e-07 -0.739086291347396 0.0696045958228138 mirMAP -0.135652814910086 0.000851140820930795 NA NA NA hsa-miR-532-5p CSF2RB 1.55697650978597 1.57884735535196e-11 -0.739086291347396 0.0696045958228138 MirTarget -0.208350232426084 0.0129885839785501 NA NA NA hsa-miR-576-5p CSF2RB 2.20467023993664 3.4053475193793e-19 -0.739086291347396 0.0696045958228138 miRNATAP -0.289248506739264 0.000161113961006424 NA NA NA hsa-miR-141-3p CSF3 5.02396127982626 2.19224509139725e-24 -4.55276205983688 3.03447416692714e-08 TargetScan;miRNATAP -0.537552891809218 9.56020415551903e-13 NA NA NA hsa-miR-200a-3p CSF3 4.59434485520731 6.38952518573476e-18 -4.55276205983688 3.03447416692714e-08 miRNATAP -0.613641665377399 1.46471374322596e-18 NA NA NA hsa-miR-2110 CSF3 1.16625590651194 6.4784195289885e-05 -4.55276205983688 3.03447416692714e-08 miRNATAP -0.300198540131011 0.0431949985613654 NA NA NA hsa-miR-28-5p CSF3 0.230152919654905 0.0742909586754846 -4.55276205983688 3.03447416692714e-08 miRanda -0.636623692387695 0.0498690704905897 NA NA NA hsa-miR-532-3p CSF3 1.96631878320218 4.53421954361695e-13 -4.55276205983688 3.03447416692714e-08 MirTarget;miRNATAP -0.511596023696386 0.000408144598083793 NA NA NA hsa-miR-30b-3p CSF3R 0.834142820354026 0.000972582820878813 -0.24235997663033 0.563434741685528 MirTarget -0.338117174033944 2.41732637318943e-05 NA NA NA hsa-miR-361-5p CSF3R 0.971859117235239 5.30236555707088e-09 -0.24235997663033 0.563434741685528 miRanda -0.59066961558745 9.29010565293858e-07 NA NA NA hsa-miR-429 CSF3R 4.48815175680773 2.44117492218206e-17 -0.24235997663033 0.563434741685528 miRanda -0.219611610587113 1.11577253202234e-09 NA NA NA hsa-miR-940 CSF3R 3.21011374578759 2.7923171128495e-14 -0.24235997663033 0.563434741685528 MirTarget -0.292773888151162 4.72591342870772e-09 NA NA NA hsa-miR-185-3p CTF1 2.3922478518806 1.3373426768452e-14 -0.627720011797528 0.0346104189215816 MirTarget -0.188636544354389 2.35890238321397e-05 NA NA NA hsa-miR-185-5p CTF1 2.34016206907488 1.17481626642022e-26 -0.627720011797528 0.0346104189215816 MirTarget -0.250667989764583 4.88644442972763e-05 NA NA NA hsa-miR-342-3p CTF1 1.49115144672245 1.43879249744621e-07 -0.627720011797528 0.0346104189215816 miRanda -0.234657457167116 2.36614164776395e-06 NA NA NA hsa-miR-590-3p CTF1 2.59289455139753 1.03200520972022e-21 -0.627720011797528 0.0346104189215816 miRanda -0.318487593997771 4.50260667893683e-10 NA NA NA hsa-miR-140-5p EP300 0.844753502512594 3.73722278438606e-05 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.116180580124631 0.0041461159891489 NA NA NA hsa-miR-142-5p EP300 1.17581605694506 0.0018174701991234 -0.259813561364416 0.130645976324069 PITA;mirMAP;miRNATAP -0.111374437902145 2.72973348003874e-07 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p B cell lymphoma hsa-miR-186-5p EP300 1.47445398888668 3.0781726595413e-15 -0.259813561364416 0.130645976324069 miRNATAP -0.111237131829924 0.0103888927623672 NA NA NA hsa-miR-193b-3p EP300 2.25711804611899 4.1940744806631e-14 -0.259813561364416 0.130645976324069 miRNAWalker2_validate -0.105745678811168 8.10977033783005e-05 NA NA NA hsa-miR-22-3p EP300 1.21545661147757 1.61670170137775e-13 -0.259813561364416 0.130645976324069 MirTarget;miRNATAP -0.202351996320887 4.21898434047145e-05 NA NA NA hsa-miR-29b-1-5p EP300 1.55384379072167 4.76870585070176e-05 -0.259813561364416 0.130645976324069 MirTarget -0.128437592094259 1.17066262616741e-08 NA NA NA hsa-miR-342-3p EP300 1.49115144672245 1.43879249744621e-07 -0.259813561364416 0.130645976324069 MirTarget;PITA;miRanda;miRNATAP -0.216290263558714 1.26951899192842e-14 NA NA NA hsa-miR-361-3p EP300 1.07367425434318 1.73142774168958e-09 -0.259813561364416 0.130645976324069 PITA -0.267683295831071 4.11859386761575e-09 NA NA NA hsa-miR-127-3p EPOR -0.6279281852298 0.0400829468424132 0.703445818437044 0.0162854092732735 miRanda -0.164542296686865 0.000379158445729522 NA NA NA hsa-miR-214-3p EPOR -0.176344800034733 0.642485503428886 0.703445818437044 0.0162854092732735 mirMAP -0.105240778426839 0.00503968400148828 NA NA NA hsa-let-7a-5p GHR 0.618599506841644 2.76973453058748e-05 -3.38492582906153 8.02448227205103e-15 TargetScan;miRNATAP -0.489851683553939 0.00106341423193965 NA NA NA hsa-let-7b-5p GHR 0.604314269683977 0.00140009936153214 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.374234097857817 0.00125741607753096 NA NA NA hsa-let-7e-5p GHR 0.860104282510173 6.04758298373779e-05 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.350103011947092 0.000563515090589899 NA NA NA hsa-let-7f-5p GHR 0.495648727272215 0.00355972741198794 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.44040158134168 0.00068069286302874 NA NA NA hsa-let-7g-5p GHR 1.20061455355116 1.50237505511483e-12 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.989338476591974 7.89193758898709e-16 NA NA NA hsa-miR-126-5p GHR 0.895338176458417 2.33372756450713e-05 -3.38492582906153 8.02448227205103e-15 MirTarget;mirMAP -0.211480443669357 0.0405425003729238 NA NA NA hsa-miR-142-3p GHR 2.75247908790621 1.45636065474764e-12 -3.38492582906153 8.02448227205103e-15 MirTarget;PITA;miRanda;miRNATAP -0.163399868827137 0.00271425541508256 NA NA NA hsa-miR-15a-5p GHR 2.34669284378787 1.69544424500258e-23 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.725130632734417 1.45411770458954e-17 NA NA NA hsa-miR-15b-5p GHR 1.57112623124278 9.14247846750597e-13 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.775340036501137 1.33519810378816e-16 NA NA NA hsa-miR-16-2-3p GHR 2.31623086727196 4.29838149388188e-20 -3.38492582906153 8.02448227205103e-15 mirMAP -0.681238766716628 1.30028462785214e-17 NA NA NA hsa-miR-16-5p GHR 1.75824877145857 1.68592440033108e-16 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.877331601703521 2.25054067493016e-20 NA NA NA hsa-miR-29a-5p GHR 1.46749674755271 3.34605004270294e-07 -3.38492582906153 8.02448227205103e-15 mirMAP;miRNATAP -0.398759363404256 3.8065582362983e-07 NA NA NA hsa-miR-3065-5p GHR 2.74629919868982 1.86846589298284e-08 -3.38492582906153 8.02448227205103e-15 MirTarget -0.234228533973949 1.16976592970447e-05 NA NA NA hsa-miR-33a-3p GHR 1.72765312072219 1.51784443453521e-07 -3.38492582906153 8.02448227205103e-15 miRNATAP -0.439955945280007 4.68048373449322e-10 NA NA NA hsa-miR-3607-3p GHR 2.68532138541128 5.66716351955047e-14 -3.38492582906153 8.02448227205103e-15 mirMAP -0.401827059830289 1.40697928073205e-11 NA NA NA hsa-miR-361-5p GHR 0.971859117235239 5.30236555707088e-09 -3.38492582906153 8.02448227205103e-15 miRanda -0.907977785941464 1.08517830269139e-12 NA NA NA hsa-miR-421 GHR 1.17791565395543 6.78526676976629e-06 -3.38492582906153 8.02448227205103e-15 miRanda -0.407158287477524 7.31048308168014e-07 NA NA NA hsa-miR-424-5p GHR 1.61930224569578 1.89642549274994e-10 -3.38492582906153 8.02448227205103e-15 MirTarget;miRNATAP -0.375073088269749 7.4050786109638e-06 NA NA NA hsa-miR-429 GHR 4.48815175680773 2.44117492218206e-17 -3.38492582906153 8.02448227205103e-15 miRanda;miRNATAP -0.353072088127256 6.98086999082263e-21 NA NA NA hsa-miR-455-5p GHR 2.2582442061694 1.43472128037398e-13 -3.38492582906153 8.02448227205103e-15 miRanda -0.288005479017098 2.99968917323832e-05 NA NA NA hsa-miR-491-5p GHR 0.615770352820862 0.0418295628761654 -3.38492582906153 8.02448227205103e-15 miRanda -0.252112855528744 0.00110544469002084 NA NA NA hsa-miR-590-3p GHR 2.59289455139753 1.03200520972022e-21 -3.38492582906153 8.02448227205103e-15 mirMAP -0.634448400274296 7.47892324972576e-17 NA NA NA hsa-miR-624-5p GHR 1.47043111118159 8.25080691741182e-09 -3.38492582906153 8.02448227205103e-15 MirTarget -0.346198820430003 7.24372283956265e-05 NA NA NA hsa-miR-651-5p GHR 2.32951837918862 1.62508965949028e-11 -3.38492582906153 8.02448227205103e-15 MirTarget -0.413836991843524 1.26883217498809e-09 NA NA NA hsa-miR-7-1-3p GHR 1.84950311431067 1.25300363397654e-13 -3.38492582906153 8.02448227205103e-15 MirTarget;mirMAP -0.615754978567405 1.07102766811281e-13 NA NA NA hsa-miR-944 GHR 2.91186649218281 1.31574753528144e-06 -3.38492582906153 8.02448227205103e-15 MirTarget;PITA;mirMAP -0.271318533457072 3.74851354788153e-14 NA NA NA hsa-miR-320a GRB2 0.438165828017084 0.0390159073347133 0.0788721517658564 0.390920910556044 MirTarget;miRanda;mirMAP;miRNATAP -0.105017257701224 3.72382950677321e-07 NA NA NA hsa-miR-125a-5p IFNG 0.599529391575274 0.0102300147180307 0.730652903235741 0.241316232029331 miRanda -0.796445342539644 4.0129599473011e-10 NA NA NA hsa-miR-429 IFNG 4.48815175680773 2.44117492218206e-17 0.730652903235741 0.241316232029331 miRanda -0.33666497744537 3.26614656153225e-10 NA NA NA hsa-miR-98-5p IFNGR1 1.11154309866014 1.24143909012085e-08 -0.152461512869484 0.415720660028279 miRNAWalker2_validate -0.214203997627061 2.63521831579226e-06 NA NA NA hsa-let-7a-5p IL10 0.618599506841644 2.76973453058748e-05 -0.985935191660191 0.030813458249972 TargetScan;miRNATAP -0.816728585777968 5.29788364555282e-08 NA NA NA hsa-let-7b-5p IL10 0.604314269683977 0.00140009936153214 -0.985935191660191 0.030813458249972 miRNATAP -0.46567354211379 7.19050995516761e-05 NA NA NA hsa-let-7d-5p IL10 1.33236798905207 1.1741085658466e-13 -0.985935191660191 0.030813458249972 miRNATAP -0.589984363020562 8.68002690727954e-07 NA NA NA hsa-let-7e-5p IL10 0.860104282510173 6.04758298373779e-05 -0.985935191660191 0.030813458249972 miRNATAP -0.485641787255752 2.07223596362528e-06 NA NA NA hsa-let-7f-5p IL10 0.495648727272215 0.00355972741198794 -0.985935191660191 0.030813458249972 miRNATAP -0.388350895071713 0.00319057597639156 NA NA NA hsa-let-7g-5p IL10 1.20061455355116 1.50237505511483e-12 -0.985935191660191 0.030813458249972 miRNATAP -0.637484714315915 5.71962485678061e-07 NA NA NA hsa-miR-106a-5p IL10 2.48882002962836 1.99757727374521e-12 -0.985935191660191 0.030813458249972 miRNAWalker2_validate -0.290478145256164 1.46087579355316e-06 NA NA NA hsa-miR-2110 IL10 1.16625590651194 6.4784195289885e-05 -0.985935191660191 0.030813458249972 miRNATAP -0.38407649312658 1.73383112430637e-06 NA NA NA hsa-miR-32-3p IL10 2.02436999565685 5.94091197945307e-09 -0.985935191660191 0.030813458249972 mirMAP -0.336073942649618 1.98984335269836e-06 NA NA NA hsa-miR-361-5p IL10 0.971859117235239 5.30236555707088e-09 -0.985935191660191 0.030813458249972 MirTarget;PITA;miRanda;miRNATAP -0.917102007242168 1.35928185513529e-12 NA NA NA hsa-miR-421 IL10 1.17791565395543 6.78526676976629e-06 -0.985935191660191 0.030813458249972 miRanda -0.228930935814166 0.00656377332271367 NA NA NA hsa-miR-590-3p IL10 2.59289455139753 1.03200520972022e-21 -0.985935191660191 0.030813458249972 miRanda;mirMAP -0.206363006012356 0.00994007896752224 NA NA NA hsa-miR-590-5p IL10 3.18300989862077 2.06813568597893e-26 -0.985935191660191 0.030813458249972 miRanda -0.24537993644713 0.000571760584037633 NA NA NA hsa-miR-769-5p IL10 1.82023760596845 9.6815886564134e-14 -0.985935191660191 0.030813458249972 miRNATAP -0.577483505648636 2.21602461497962e-11 NA NA NA hsa-miR-125a-5p IL10RA 0.599529391575274 0.0102300147180307 -1.37133661605832 0.000407351606953237 miRanda -0.417843492369792 1.9412670510322e-07 NA NA NA hsa-miR-320a IL10RA 0.438165828017084 0.0390159073347133 -1.37133661605832 0.000407351606953237 miRanda -0.458735978576139 2.2700328027629e-07 NA NA NA hsa-miR-320b IL10RA 1.55692969039548 1.41071034251915e-08 -1.37133661605832 0.000407351606953237 miRanda -0.429569715717963 1.03901600594249e-10 NA NA NA hsa-miR-330-5p IL10RA 1.15100069700871 4.85551805046014e-07 -1.37133661605832 0.000407351606953237 miRanda -0.245108667023428 0.00277830471442013 NA NA NA hsa-miR-421 IL10RA 1.17791565395543 6.78526676976629e-06 -1.37133661605832 0.000407351606953237 miRanda -0.360153353481971 4.08208719552607e-07 NA NA NA hsa-miR-330-5p IL11RA 1.15100069700871 4.85551805046014e-07 -1.47963737013117 6.34207553100327e-11 miRanda -0.251898421942843 1.63078356367592e-07 NA NA NA hsa-miR-429 IL12A 4.48815175680773 2.44117492218206e-17 -0.682042307570187 0.0964011690357591 miRanda -0.13641858559467 0.000137175040385455 NA NA NA hsa-miR-125a-5p IL12RB2 0.599529391575274 0.0102300147180307 0.372769148854768 0.527723353953467 miRanda -1.07447825793945 5.64583370820825e-20 NA NA NA hsa-miR-28-5p IL12RB2 0.230152919654905 0.0742909586754846 0.372769148854768 0.527723353953467 miRanda -0.892027875052874 8.7982151098267e-05 NA NA NA hsa-let-7e-3p IL13RA1 0.233305597460291 0.324920002949969 0.185374242322141 0.289239058001587 MirTarget -0.148920227127107 2.94596201473395e-05 NA NA NA hsa-miR-128-3p IL13RA1 1.63756041666078 6.79626586407187e-14 0.185374242322141 0.289239058001587 MirTarget -0.153610510221635 4.19346849626913e-05 NA NA NA hsa-miR-186-5p IL13RA1 1.47445398888668 3.0781726595413e-15 0.185374242322141 0.289239058001587 MirTarget;mirMAP -0.108682864952178 0.0138522000278108 NA NA NA hsa-miR-28-5p IL13RA1 0.230152919654905 0.0742909586754846 0.185374242322141 0.289239058001587 miRanda -0.263393835936169 8.98444252679988e-05 NA NA NA hsa-miR-330-3p IL13RA1 0.876747334239085 0.00073709016089703 0.185374242322141 0.289239058001587 MirTarget;PITA;miRNATAP -0.132173967103349 4.23071896144066e-05 NA NA NA hsa-miR-361-5p IL13RA1 0.971859117235239 5.30236555707088e-09 0.185374242322141 0.289239058001587 miRanda -0.229539161622411 4.81151686685283e-06 NA NA NA hsa-miR-378a-5p IL13RA1 0.223456081148306 0.386368843153575 0.185374242322141 0.289239058001587 MirTarget -0.163376540929173 5.19315361771067e-07 NA NA NA hsa-miR-664a-5p IL13RA1 0.505019913598436 0.032933350691651 0.185374242322141 0.289239058001587 MirTarget -0.145785609542906 4.55976186051257e-05 NA NA NA hsa-miR-107 IL15 1.30977326593435 1.30372468603965e-11 -0.561691313915147 0.104404851611327 miRanda;miRNATAP -0.393903497926685 3.18868351861918e-06 NA NA NA hsa-miR-130b-3p IL15 3.5350292994509 1.73934183852569e-27 -0.561691313915147 0.104404851611327 MirTarget -0.287552944203805 1.26152640675242e-09 NA NA NA hsa-miR-148b-3p IL15 1.97815018171325 6.07715327281595e-26 -0.561691313915147 0.104404851611327 MirTarget -0.38814129011701 3.80445504519875e-06 NA NA NA hsa-miR-192-5p IL15 2.69002528723195 1.22990188194432e-16 -0.561691313915147 0.104404851611327 miRNAWalker2_validate -0.266042590627927 5.65339321908063e-08 NA NA NA hsa-miR-215-5p IL15 2.30755467422978 2.38476032118039e-06 -0.561691313915147 0.104404851611327 miRNAWalker2_validate -0.145534278747456 2.60665414172521e-05 NA NA NA hsa-miR-301a-3p IL15 2.81024345929638 2.29784847962242e-17 -0.561691313915147 0.104404851611327 MirTarget -0.187676228907966 0.000244115335167079 NA NA NA hsa-miR-3065-5p IL15 2.74629919868982 1.86846589298284e-08 -0.561691313915147 0.104404851611327 mirMAP -0.109630268085725 0.00793491196058695 NA NA NA hsa-miR-324-5p IL15 2.95683728155095 1.32960514360912e-20 -0.561691313915147 0.104404851611327 miRanda -0.191230627368865 0.000132351815883966 NA NA NA hsa-miR-421 IL15 1.17791565395543 6.78526676976629e-06 -0.561691313915147 0.104404851611327 miRanda -0.12654947326093 0.0474514399446066 NA NA NA hsa-miR-429 IL15 4.48815175680773 2.44117492218206e-17 -0.561691313915147 0.104404851611327 miRanda -0.260013704694446 3.28859887667923e-19 NA NA NA hsa-miR-450b-5p IL15 1.69244418548325 1.68064054148881e-10 -0.561691313915147 0.104404851611327 MirTarget -0.25182345817763 4.45681905000812e-05 NA NA NA hsa-miR-542-3p IL15 1.18832665895751 1.98700670691565e-07 -0.561691313915147 0.104404851611327 miRanda -0.236491799661947 0.00111813079715954 NA NA NA hsa-miR-125a-5p IL15RA 0.599529391575274 0.0102300147180307 -0.238342793156716 0.520044602405546 miRanda -0.443428545168732 4.95115382560526e-09 NA NA NA hsa-miR-28-5p IL15RA 0.230152919654905 0.0742909586754846 -0.238342793156716 0.520044602405546 miRanda -0.537513460861848 0.000167517800221479 NA NA NA hsa-miR-140-5p IL20RA 0.844753502512594 3.73722278438606e-05 0.713677535753439 0.0930777368240817 miRanda -0.231642453267605 0.0213725645229318 NA NA NA hsa-miR-338-3p IL20RA 0.453166438193782 0.144583389707558 0.713677535753439 0.0930777368240817 miRanda -0.202646129048038 0.00223396238117909 NA NA NA hsa-miR-374b-5p IL20RA 0.0654362503857184 0.722673188879465 0.713677535753439 0.0930777368240817 mirMAP -0.442472789685432 8.62003258604807e-05 NA NA NA hsa-miR-28-5p IL20RB 0.230152919654905 0.0742909586754846 0.855893422954078 0.165732095073442 miRanda -0.815114289100964 0.000638003852855362 NA NA NA hsa-miR-148b-3p IL21R 1.97815018171325 6.07715327281595e-26 0.146110028791808 0.782734471713055 miRNAWalker2_validate -0.584976293508514 5.3524149642358e-06 NA NA NA hsa-miR-335-5p IL21R 1.77247705492746 2.22457658872091e-06 0.146110028791808 0.782734471713055 miRNAWalker2_validate -0.17064934775216 0.0116059153915024 NA NA NA hsa-miR-421 IL21R 1.17791565395543 6.78526676976629e-06 0.146110028791808 0.782734471713055 miRanda -0.287023937030208 0.00321417713634214 NA NA NA hsa-miR-484 IL21R 1.81844463411787 1.82951571230938e-15 0.146110028791808 0.782734471713055 MirTarget -0.300295895242451 0.00578799078382545 NA NA NA hsa-miR-491-5p IL21R 0.615770352820862 0.0418295628761654 0.146110028791808 0.782734471713055 MirTarget;miRanda -0.207548836015267 0.0225926979668321 NA NA NA hsa-miR-129-5p IL22RA2 -0.524170159980738 0.222582956006346 0.920668404956109 0.102782710135805 miRanda -0.196335300872718 0.00242805650755813 NA NA NA hsa-miR-186-5p IL22RA2 1.47445398888668 3.0781726595413e-15 0.920668404956109 0.102782710135805 mirMAP -0.377879947052498 0.00818343547745607 NA NA NA hsa-miR-335-3p IL22RA2 3.08791651139852 5.31309869723517e-12 0.920668404956109 0.102782710135805 mirMAP -0.161952762376418 0.00636256277649679 NA NA NA hsa-miR-33a-3p IL22RA2 1.72765312072219 1.51784443453521e-07 0.920668404956109 0.102782710135805 mirMAP -0.446009954850924 5.66063619247035e-07 NA NA NA hsa-miR-421 IL22RA2 1.17791565395543 6.78526676976629e-06 0.920668404956109 0.102782710135805 miRanda -0.216485689596529 0.0377061383638199 NA NA NA hsa-miR-324-3p IL24 2.08739139768981 3.11885987067952e-13 0.485667499509913 0.456901075935217 MirTarget -0.301838362302575 0.00490434537558191 NA NA NA hsa-miR-361-5p IL24 0.971859117235239 5.30236555707088e-09 0.485667499509913 0.456901075935217 miRanda -0.785598303617897 2.98150596042639e-05 NA NA NA hsa-miR-429 IL24 4.48815175680773 2.44117492218206e-17 0.485667499509913 0.456901075935217 miRanda -0.241953644173784 2.01377463377342e-05 NA NA NA hsa-miR-224-3p IL2RA 1.87536386559317 6.15140969394846e-05 -0.168267799080654 0.754364221522117 MirTarget -0.327905379108166 7.67886781749462e-09 NA NA NA hsa-miR-3065-3p IL2RA 2.16221780121195 9.65525739884541e-09 -0.168267799080654 0.754364221522117 MirTarget -0.260522406991479 0.000112050511124378 NA NA NA hsa-miR-3607-3p IL2RA 2.68532138541128 5.66716351955047e-14 -0.168267799080654 0.754364221522117 mirMAP -0.184080402382259 0.0111264335037544 NA NA NA hsa-miR-3677-3p IL2RA 1.55935355925312 4.80239289905323e-06 -0.168267799080654 0.754364221522117 MirTarget -0.149088365608177 0.0486998759790827 NA NA NA hsa-miR-375 IL2RA 1.13910305294079 0.0512283522214186 -0.168267799080654 0.754364221522117 miRanda -0.106576857812083 0.0163371615026233 NA NA NA hsa-let-7d-3p IL2RB 0.837345596411224 1.39469480391458e-05 -0.0233290268117248 0.954819309152745 mirMAP -0.369222486322037 0.000342913795676839 NA NA NA hsa-miR-125a-5p IL2RB 0.599529391575274 0.0102300147180307 -0.0233290268117248 0.954819309152745 miRanda -0.442253532537528 1.70969907539695e-07 NA NA NA hsa-miR-30b-3p IL2RB 0.834142820354026 0.000972582820878813 -0.0233290268117248 0.954819309152745 mirMAP -0.480203015370178 6.24300873871078e-10 NA NA NA hsa-miR-421 IL2RB 1.17791565395543 6.78526676976629e-06 -0.0233290268117248 0.954819309152745 mirMAP -0.187821218773603 0.0132150307245737 NA NA NA hsa-miR-421 IL2RG 1.17791565395543 6.78526676976629e-06 -0.126168361757179 0.782139842106464 miRanda;miRNATAP -0.272273105936814 0.00115453548509555 NA NA NA hsa-miR-491-5p IL2RG 0.615770352820862 0.0418295628761654 -0.126168361757179 0.782139842106464 miRanda -0.168541541048309 0.031563801699543 NA NA NA hsa-miR-331-3p IL4R 2.28379581858927 1.99663919173155e-18 -0.389473278837841 0.0949302027470816 miRNAWalker2_validate -0.220635955939197 7.76238081274503e-08 NA NA NA hsa-miR-339-5p IL4R 2.68710938429893 3.03134080808154e-16 -0.389473278837841 0.0949302027470816 miRanda -0.15226325804297 3.44301444278975e-06 NA NA NA hsa-miR-429 IL4R 4.48815175680773 2.44117492218206e-17 -0.389473278837841 0.0949302027470816 miRNATAP -0.126344342256496 2.7572092258889e-10 NA NA NA hsa-miR-491-5p IL4R 0.615770352820862 0.0418295628761654 -0.389473278837841 0.0949302027470816 miRanda -0.171311339821391 1.64313357660503e-05 NA NA NA hsa-let-7a-5p IL6 0.618599506841644 2.76973453058748e-05 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -1.49764192032347 2.38346175895915e-10 21352471;23977098 Knocking down IL-6 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion;Loss of let 7 microRNA upregulates IL 6 in bone marrow derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer; We also found that IL-6 is a direct target gene for the let-7 microRNA which was downregulated in cancer-associated MSCs; The overexpression of let-7 via the transfection of let-7 precursors decreased IL-6 expression and repressed the adipogenic potential and metastasis-promoting activity of cancer-associated MSCs which was consistent with the inhibition of IL-6 3'UTR luciferase activity; Conversely the treatment of normal MSCs with let-7 inhibitors resulted in effects similar to those seen with IL-6; Taken together our data demonstrated that MSCs co-evolve with prostate cancer cells in the tumor microenvironment and the downregulation of let-7 by cancer-associated MSCs upregulates IL-6 expression drug resistance;drug resistance;metastasis liver cancer;prostate cancer hsa-miR-107 IL6 1.30977326593435 1.30372468603965e-11 -4.51457391074354 1.84664878324708e-10 miRanda -1.33183779333917 1.54734218444571e-14 NA NA NA hsa-miR-335-5p IL6 1.77247705492746 2.22457658872091e-06 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -0.467167119193204 3.30170788121676e-07 NA NA NA hsa-miR-361-5p IL6 0.971859117235239 5.30236555707088e-09 -4.51457391074354 1.84664878324708e-10 miRanda -1.82491350948499 1.24082346226555e-19 NA NA NA hsa-miR-429 IL6 4.48815175680773 2.44117492218206e-17 -4.51457391074354 1.84664878324708e-10 miRanda -0.671855968964194 6.61057721414734e-30 NA NA NA hsa-miR-98-5p IL6 1.11154309866014 1.24143909012085e-08 -4.51457391074354 1.84664878324708e-10 miRNAWalker2_validate -1.23406095672236 1.33158050901419e-12 25277211 miR 98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL 6; We also found that IL-6 is a target gene of miR-98 and IL-6 represses miR-98 levels via the Stat3-NF-κB-lin28B pathway metastasis melanoma hsa-let-7e-5p IL6R 0.860104282510173 6.04758298373779e-05 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.355369511566587 8.37378549008563e-05 NA NA NA hsa-let-7g-5p IL6R 1.20061455355116 1.50237505511483e-12 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.5865859753066 1.60279544877185e-07 NA NA NA hsa-miR-103a-2-5p IL6R 2.47599305985086 7.933028987326e-11 -1.86576803083567 2.67166891084766e-06 mirMAP -0.279653165564326 5.81104413496993e-07 NA NA NA hsa-miR-106a-5p IL6R 2.48882002962836 1.99757727374521e-12 -1.86576803083567 2.67166891084766e-06 mirMAP -0.189044848105555 0.000396201599215425 NA NA NA hsa-miR-106b-5p IL6R 2.46782146831112 1.36171495805632e-23 -1.86576803083567 2.67166891084766e-06 mirMAP -0.545921256955192 6.72141166862895e-14 NA NA NA hsa-miR-125a-5p IL6R 0.599529391575274 0.0102300147180307 -1.86576803083567 2.67166891084766e-06 MirTarget;miRanda -0.430695896757453 1.91909957244903e-07 NA NA NA hsa-miR-130a-3p IL6R 2.02021855058359 1.26427102520415e-11 -1.86576803083567 2.67166891084766e-06 mirMAP -0.185169000844622 0.00364857336821356 NA NA NA hsa-miR-130b-3p IL6R 3.5350292994509 1.73934183852569e-27 -1.86576803083567 2.67166891084766e-06 mirMAP -0.368732744561779 1.67517848881662e-11 NA NA NA hsa-miR-141-3p IL6R 5.02396127982626 2.19224509139725e-24 -1.86576803083567 2.67166891084766e-06 MirTarget -0.23775486835915 6.49333048566365e-11 NA NA NA hsa-miR-141-5p IL6R 3.81419396518882 3.21977359736126e-18 -1.86576803083567 2.67166891084766e-06 MirTarget -0.207068782348747 8.62358173694999e-07 NA NA NA hsa-miR-17-5p IL6R 3.2710598467455 9.93128340539455e-27 -1.86576803083567 2.67166891084766e-06 mirMAP -0.333756021656699 1.48032494389695e-08 NA NA NA hsa-miR-182-5p IL6R 3.53923166221814 5.07781258121574e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.308185867210701 1.67894161264071e-10 NA NA NA hsa-miR-186-5p IL6R 1.47445398888668 3.0781726595413e-15 -1.86576803083567 2.67166891084766e-06 mirMAP -0.500045040442012 6.86522427682879e-07 NA NA NA hsa-miR-192-5p IL6R 2.69002528723195 1.22990188194432e-16 -1.86576803083567 2.67166891084766e-06 mirMAP -0.216653822911565 0.000163354472974362 NA NA NA hsa-miR-193a-3p IL6R 1.60460546928078 2.86169793322984e-07 -1.86576803083567 2.67166891084766e-06 mirMAP -0.130823019043723 0.0336168147801737 NA NA NA hsa-miR-193b-3p IL6R 2.25711804611899 4.1940744806631e-14 -1.86576803083567 2.67166891084766e-06 mirMAP -0.152923395920601 0.0156662699756225 NA NA NA hsa-miR-197-3p IL6R 1.75733174019505 8.88576793100499e-13 -1.86576803083567 2.67166891084766e-06 MirTarget -0.392610198312442 2.82127657316037e-07 NA NA NA hsa-miR-200a-3p IL6R 4.59434485520731 6.38952518573476e-18 -1.86576803083567 2.67166891084766e-06 MirTarget -0.280132988638321 9.88549165158644e-17 NA NA NA hsa-miR-20a-5p IL6R 3.15577933619191 4.19753346442454e-25 -1.86576803083567 2.67166891084766e-06 mirMAP -0.341831252511955 8.08465079689935e-09 NA NA NA hsa-miR-20b-5p IL6R 2.07706563022469 1.10107236083433e-05 -1.86576803083567 2.67166891084766e-06 mirMAP -0.173346507000992 1.81889860281569e-05 NA NA NA hsa-miR-28-5p IL6R 0.230152919654905 0.0742909586754846 -1.86576803083567 2.67166891084766e-06 mirMAP -0.445627685956472 0.00421342118577506 NA NA NA hsa-miR-301a-3p IL6R 2.81024345929638 2.29784847962242e-17 -1.86576803083567 2.67166891084766e-06 mirMAP -0.346207501246887 3.74645493389162e-09 NA NA NA hsa-miR-3065-5p IL6R 2.74629919868982 1.86846589298284e-08 -1.86576803083567 2.67166891084766e-06 mirMAP -0.215521603126446 6.01795162352935e-06 NA NA NA hsa-miR-30b-5p IL6R 0.800822374912712 0.000133601914525413 -1.86576803083567 2.67166891084766e-06 mirMAP -0.216302759975483 0.0201581087173427 NA NA NA hsa-miR-30c-5p IL6R 0.778774633108 0.000285599212429136 -1.86576803083567 2.67166891084766e-06 mirMAP -0.357730501275482 7.58292460792626e-05 NA NA NA hsa-miR-30d-5p IL6R 0.675423997639582 0.00270618816039773 -1.86576803083567 2.67166891084766e-06 mirMAP -0.310006276899415 0.000334351035391643 NA NA NA hsa-miR-30e-5p IL6R 1.23904909539663 1.35561917122157e-09 -1.86576803083567 2.67166891084766e-06 mirMAP -0.450037358977164 1.41115867585131e-06 NA NA NA hsa-miR-320b IL6R 1.55692969039548 1.41071034251915e-08 -1.86576803083567 2.67166891084766e-06 miRanda;miRNATAP -0.156061169485727 0.0257833362287906 NA NA NA hsa-miR-330-3p IL6R 0.876747334239085 0.00073709016089703 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.177412033833072 0.0178867244488029 NA NA NA hsa-miR-331-3p IL6R 2.28379581858927 1.99663919173155e-18 -1.86576803083567 2.67166891084766e-06 MirTarget -0.286157934626183 6.1127020326213e-05 NA NA NA hsa-miR-335-5p IL6R 1.77247705492746 2.22457658872091e-06 -1.86576803083567 2.67166891084766e-06 mirMAP -0.268753965716292 1.15867215559052e-07 NA NA NA hsa-miR-33a-5p IL6R 3.79671563098419 1.15966309820345e-18 -1.86576803083567 2.67166891084766e-06 mirMAP -0.205688942132961 1.09391389822686e-05 NA NA NA hsa-miR-34a-5p IL6R 1.9016323452565 1.43092834643601e-14 -1.86576803083567 2.67166891084766e-06 MirTarget -0.286520476038065 0.000171312695111806 NA NA NA hsa-miR-421 IL6R 1.17791565395543 6.78526676976629e-06 -1.86576803083567 2.67166891084766e-06 mirMAP -0.195154738362018 0.00842534304798536 NA NA NA hsa-miR-454-3p IL6R 2.47234127820054 1.12878018736016e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.34587032830449 2.25174449017626e-06 NA NA NA hsa-miR-484 IL6R 1.81844463411787 1.82951571230938e-15 -1.86576803083567 2.67166891084766e-06 MirTarget -0.433592636178605 1.10167451298998e-07 NA NA NA hsa-miR-501-5p IL6R 1.93654809410041 1.3779381780759e-10 -1.86576803083567 2.67166891084766e-06 miRNATAP -0.220656896683197 0.000676165915415221 NA NA NA hsa-miR-576-5p IL6R 2.20467023993664 3.4053475193793e-19 -1.86576803083567 2.67166891084766e-06 mirMAP -0.324022701493948 1.74337424075385e-05 NA NA NA hsa-miR-590-3p IL6R 2.59289455139753 1.03200520972022e-21 -1.86576803083567 2.67166891084766e-06 mirMAP -0.160281674908149 0.0228989302000628 NA NA NA hsa-miR-590-5p IL6R 3.18300989862077 2.06813568597893e-26 -1.86576803083567 2.67166891084766e-06 MirTarget;miRNATAP -0.269600006996991 1.54974226114691e-05 NA NA NA hsa-miR-93-5p IL6R 3.03961860136032 1.11672209617395e-24 -1.86576803083567 2.67166891084766e-06 mirMAP -0.461620151648295 1.68707665863151e-14 NA NA NA hsa-miR-942-5p IL6R 2.35195531153712 5.45059325728841e-16 -1.86576803083567 2.67166891084766e-06 MirTarget -0.130829802134946 0.0437842831734132 NA NA NA hsa-miR-98-5p IL6R 1.11154309866014 1.24143909012085e-08 -1.86576803083567 2.67166891084766e-06 miRNAWalker2_validate -0.469481304122954 1.71027380188651e-06 NA NA NA hsa-let-7a-3p IL6ST 1.42015538786275 7.03375209382654e-13 -2.09967019941458 1.93264814611531e-05 mirMAP -0.357378791661437 0.00268509792596891 NA NA NA hsa-miR-101-5p IL6ST 0.782067874775122 0.00443725251526842 -2.09967019941458 1.93264814611531e-05 mirMAP -0.243120616165065 0.00692104461754632 NA NA NA hsa-miR-103a-3p IL6ST 1.44083190496858 1.53799939616416e-13 -2.09967019941458 1.93264814611531e-05 mirMAP -0.830435329177953 1.71447873536999e-12 NA NA NA hsa-miR-1301-3p IL6ST 2.54959518791507 5.26618591274892e-18 -2.09967019941458 1.93264814611531e-05 MirTarget -0.488259258730299 2.00916819472426e-10 NA NA NA hsa-miR-130a-3p IL6ST 2.02021855058359 1.26427102520415e-11 -2.09967019941458 1.93264814611531e-05 mirMAP;miRNATAP -0.331457368822387 2.2288904351232e-05 NA NA NA hsa-miR-130b-3p IL6ST 3.5350292994509 1.73934183852569e-27 -2.09967019941458 1.93264814611531e-05 miRNATAP -0.396551016744198 5.60970696457409e-09 NA NA NA hsa-miR-136-5p IL6ST 2.09637138292451 1.50140005592201e-10 -2.09967019941458 1.93264814611531e-05 MirTarget -0.352506543842381 7.08116223081324e-07 NA NA NA hsa-miR-148a-3p IL6ST 1.26728238710376 2.52325607402829e-06 -2.09967019941458 1.93264814611531e-05 MirTarget;miRNATAP -0.300400298752387 0.000664454564010511 NA NA NA hsa-miR-148b-3p IL6ST 1.97815018171325 6.07715327281595e-26 -2.09967019941458 1.93264814611531e-05 MirTarget -0.764983785636432 1.31917236089946e-10 NA NA NA hsa-miR-148b-5p IL6ST 2.18024067300781 2.84770452413262e-14 -2.09967019941458 1.93264814611531e-05 mirMAP -0.542395169500905 1.25282861250266e-10 NA NA NA hsa-miR-16-1-3p IL6ST 2.56983217111073 3.02262181237943e-20 -2.09967019941458 1.93264814611531e-05 mirMAP -0.539420035293678 7.74041291632269e-11 NA NA NA hsa-miR-16-2-3p IL6ST 2.31623086727196 4.29838149388188e-20 -2.09967019941458 1.93264814611531e-05 mirMAP -0.491745812449546 4.62371404532856e-08 NA NA NA hsa-miR-17-5p IL6ST 3.2710598467455 9.93128340539455e-27 -2.09967019941458 1.93264814611531e-05 TargetScan -0.546011971181206 2.47108597973129e-14 NA NA NA hsa-miR-181a-5p IL6ST 2.29556023480783 1.8138457900616e-21 -2.09967019941458 1.93264814611531e-05 mirMAP -0.64549463975504 3.56291865845698e-12 NA NA NA hsa-miR-181b-5p IL6ST 2.49307679431293 3.92829250217627e-20 -2.09967019941458 1.93264814611531e-05 mirMAP -0.502865497706721 1.54037397104747e-09 NA NA NA hsa-miR-181c-5p IL6ST 1.58587920618301 1.57506918816933e-10 -2.09967019941458 1.93264814611531e-05 mirMAP -0.615675799400144 3.93223659800214e-11 NA NA NA hsa-miR-182-5p IL6ST 3.53923166221814 5.07781258121574e-21 -2.09967019941458 1.93264814611531e-05 mirMAP -0.422787250881008 9.05725280154988e-13 NA NA NA hsa-miR-186-5p IL6ST 1.47445398888668 3.0781726595413e-15 -2.09967019941458 1.93264814611531e-05 MirTarget;mirMAP -0.829205740194413 1.43405218570935e-11 NA NA NA hsa-miR-192-5p IL6ST 2.69002528723195 1.22990188194432e-16 -2.09967019941458 1.93264814611531e-05 miRNAWalker2_validate -0.309081368306106 1.23812969126085e-05 NA NA NA hsa-miR-19a-3p IL6ST 3.42309334186656 3.02671914353412e-28 -2.09967019941458 1.93264814611531e-05 mirMAP;miRNATAP -0.554865555959229 2.25704487814064e-15 NA NA NA hsa-miR-19b-3p IL6ST 2.49529833021187 1.57028265846699e-23 -2.09967019941458 1.93264814611531e-05 mirMAP;miRNATAP -0.70786679532936 1.14825735596692e-15 NA NA NA hsa-miR-200a-5p IL6ST 3.86316681673704 1.81076942093171e-15 -2.09967019941458 1.93264814611531e-05 mirMAP -0.31973238655528 6.37731739815688e-12 NA NA NA hsa-miR-200b-3p IL6ST 3.78235093249346 3.18343003239465e-14 -2.09967019941458 1.93264814611531e-05 TargetScan;mirMAP -0.299658065744645 5.01887474532989e-11 NA NA NA hsa-miR-200b-5p IL6ST 2.54484902707822 1.59240467582976e-06 -2.09967019941458 1.93264814611531e-05 mirMAP -0.213446975976385 2.05563304567144e-05 NA NA NA hsa-miR-200c-3p IL6ST 3.50132673580082 2.42716349086937e-15 -2.09967019941458 1.93264814611531e-05 mirMAP -0.351735931542591 6.11651430778903e-12 NA NA NA hsa-miR-20a-3p IL6ST 2.92621109947706 2.49504904635375e-17 -2.09967019941458 1.93264814611531e-05 mirMAP -0.429803142085319 1.68721499192023e-10 NA NA NA hsa-miR-21-5p IL6ST 2.73773305747971 1.38864982139576e-43 -2.09967019941458 1.93264814611531e-05 mirMAP -0.398416947498625 0.000280432454628999 NA NA NA hsa-miR-2110 IL6ST 1.16625590651194 6.4784195289885e-05 -2.09967019941458 1.93264814611531e-05 MirTarget -0.21684703414311 0.0137487037767536 NA NA NA hsa-miR-215-5p IL6ST 2.30755467422978 2.38476032118039e-06 -2.09967019941458 1.93264814611531e-05 miRNAWalker2_validate -0.147322634815022 0.00315578063648938 NA NA NA hsa-miR-219a-1-3p IL6ST 1.14752647140971 0.00048791524196346 -2.09967019941458 1.93264814611531e-05 MirTarget -0.39911766919939 8.99624077764586e-07 NA NA NA hsa-miR-24-1-5p IL6ST 0.333970971402977 0.135651278931933 -2.09967019941458 1.93264814611531e-05 MirTarget -0.306001886100149 0.00463055498945197 NA NA NA hsa-miR-24-2-5p IL6ST 2.07171035460647 3.15853539996136e-16 -2.09967019941458 1.93264814611531e-05 MirTarget -0.383598577142739 2.51582185607065e-05 NA NA NA hsa-miR-26a-2-3p IL6ST 0.823520019989974 0.00017092160823769 -2.09967019941458 1.93264814611531e-05 MirTarget -0.472341071006244 1.6526775467444e-05 NA NA NA hsa-miR-26b-5p IL6ST 0.885393662798425 3.2116297961629e-06 -2.09967019941458 1.93264814611531e-05 mirMAP -0.681173849246414 4.7071350539905e-08 NA NA NA hsa-miR-29a-5p IL6ST 1.46749674755271 3.34605004270294e-07 -2.09967019941458 1.93264814611531e-05 mirMAP -0.311862758819382 0.000341575091544501 NA NA NA hsa-miR-29b-1-5p IL6ST 1.55384379072167 4.76870585070176e-05 -2.09967019941458 1.93264814611531e-05 MirTarget -0.209667029291384 0.00149575823557862 NA NA NA hsa-miR-29b-2-5p IL6ST 0.910668640983475 0.00666655585493488 -2.09967019941458 1.93264814611531e-05 mirMAP -0.487458898329733 2.79159321499606e-12 NA NA NA hsa-miR-29b-3p IL6ST 1.65828197923813 1.02676780888141e-09 -2.09967019941458 1.93264814611531e-05 mirMAP -0.574545717500617 1.37944030153369e-11 NA NA NA hsa-miR-29c-3p IL6ST -0.00968972577705429 0.97099586346872 -2.09967019941458 1.93264814611531e-05 mirMAP -0.256046192695279 0.004690774685649 NA NA NA hsa-miR-301a-3p IL6ST 2.81024345929638 2.29784847962242e-17 -2.09967019941458 1.93264814611531e-05 mirMAP;miRNATAP -0.51570837504316 6.65606533415112e-13 NA NA NA hsa-miR-3065-3p IL6ST 2.16221780121195 9.65525739884541e-09 -2.09967019941458 1.93264814611531e-05 miRNATAP -0.17895215324019 0.00421524784029766 NA NA NA hsa-miR-3065-5p IL6ST 2.74629919868982 1.86846589298284e-08 -2.09967019941458 1.93264814611531e-05 mirMAP;miRNATAP -0.197130713463603 0.000849688645669387 NA NA NA hsa-miR-30b-5p IL6ST 0.800822374912712 0.000133601914525413 -2.09967019941458 1.93264814611531e-05 mirMAP -0.507350099212773 8.43019083981057e-06 NA NA NA hsa-miR-30c-5p IL6ST 0.778774633108 0.000285599212429136 -2.09967019941458 1.93264814611531e-05 mirMAP -0.773810315756884 1.46414747831804e-12 NA NA NA hsa-miR-30d-5p IL6ST 0.675423997639582 0.00270618816039773 -2.09967019941458 1.93264814611531e-05 mirMAP -0.4136487839812 0.000102858063143522 NA NA NA hsa-miR-30e-5p IL6ST 1.23904909539663 1.35561917122157e-09 -2.09967019941458 1.93264814611531e-05 mirMAP -0.798507216698966 1.8832807595836e-12 NA NA NA hsa-miR-32-3p IL6ST 2.02436999565685 5.94091197945307e-09 -2.09967019941458 1.93264814611531e-05 mirMAP -0.313877351509783 4.54444261387931e-05 NA NA NA hsa-miR-330-3p IL6ST 0.876747334239085 0.00073709016089703 -2.09967019941458 1.93264814611531e-05 PITA;mirMAP -0.252884601380659 0.00617650176188307 NA NA NA hsa-miR-335-3p IL6ST 3.08791651139852 5.31309869723517e-12 -2.09967019941458 1.93264814611531e-05 MirTarget;mirMAP -0.252187957109469 1.0526671829944e-06 NA NA NA hsa-miR-335-5p IL6ST 1.77247705492746 2.22457658872091e-06 -2.09967019941458 1.93264814611531e-05 miRNAWalker2_validate -0.259070914244127 3.906141230235e-05 NA NA NA hsa-miR-33a-3p IL6ST 1.72765312072219 1.51784443453521e-07 -2.09967019941458 1.93264814611531e-05 mirMAP -0.156226485808253 0.0489360361893219 NA NA NA hsa-miR-33a-5p IL6ST 3.79671563098419 1.15966309820345e-18 -2.09967019941458 1.93264814611531e-05 mirMAP -0.241854645275171 2.84112922619583e-05 NA NA NA hsa-miR-361-5p IL6ST 0.971859117235239 5.30236555707088e-09 -2.09967019941458 1.93264814611531e-05 mirMAP -0.672347649762961 2.46356574772279e-06 NA NA NA hsa-miR-362-3p IL6ST 2.0756816987665 3.89026064579331e-12 -2.09967019941458 1.93264814611531e-05 PITA;miRanda;miRNATAP -0.329815840481108 4.22553724720109e-05 NA NA NA hsa-miR-362-5p IL6ST 1.59303749908759 9.582675908797e-08 -2.09967019941458 1.93264814611531e-05 mirMAP -0.434542972295944 2.83229238872769e-08 NA NA NA hsa-miR-374a-3p IL6ST 0.533309330504947 0.00192918429705142 -2.09967019941458 1.93264814611531e-05 mirMAP -0.544100391604889 0.000109049743985702 NA NA NA hsa-miR-374b-3p IL6ST 0.930487774873495 2.74420094310516e-05 -2.09967019941458 1.93264814611531e-05 MirTarget -0.435468471664045 5.44928696171107e-05 NA NA NA hsa-miR-421 IL6ST 1.17791565395543 6.78526676976629e-06 -2.09967019941458 1.93264814611531e-05 PITA;miRanda;mirMAP -0.200918598790535 0.0281488056613765 NA NA NA hsa-miR-429 IL6ST 4.48815175680773 2.44117492218206e-17 -2.09967019941458 1.93264814611531e-05 PITA;miRanda;mirMAP;miRNATAP -0.293777445584859 4.32875424228912e-12 NA NA NA hsa-miR-454-3p IL6ST 2.47234127820054 1.12878018736016e-21 -2.09967019941458 1.93264814611531e-05 mirMAP;miRNATAP -0.711522087876407 6.2531499316741e-16 NA NA NA hsa-miR-455-5p IL6ST 2.2582442061694 1.43472128037398e-13 -2.09967019941458 1.93264814611531e-05 miRanda -0.258878912592327 0.000681298277585252 NA NA NA hsa-miR-491-5p IL6ST 0.615770352820862 0.0418295628761654 -2.09967019941458 1.93264814611531e-05 miRanda -0.210025413454345 0.013787660676237 NA NA NA hsa-miR-501-5p IL6ST 1.93654809410041 1.3779381780759e-10 -2.09967019941458 1.93264814611531e-05 mirMAP -0.393183440438969 7.59293512788385e-07 NA NA NA hsa-miR-505-3p IL6ST 1.45322244209148 8.86597629645867e-10 -2.09967019941458 1.93264814611531e-05 MirTarget -0.537696920225009 4.77467130901699e-08 NA NA NA hsa-miR-532-5p IL6ST 1.55697650978597 1.57884735535196e-11 -2.09967019941458 1.93264814611531e-05 PITA -0.510242535920192 4.31125241383808e-07 NA NA NA hsa-miR-576-5p IL6ST 2.20467023993664 3.4053475193793e-19 -2.09967019941458 1.93264814611531e-05 mirMAP -0.669146409680155 2.15587965435563e-13 NA NA NA hsa-miR-582-5p IL6ST 0.609226359812689 0.032988717891497 -2.09967019941458 1.93264814611531e-05 mirMAP -0.350086527037346 2.8632161925819e-05 NA NA NA hsa-miR-584-5p IL6ST 2.7326672683732 9.92677936962233e-12 -2.09967019941458 1.93264814611531e-05 mirMAP -0.197749223410721 0.000667818479545981 NA NA NA hsa-miR-589-3p IL6ST 2.51971841868825 2.39125940264107e-11 -2.09967019941458 1.93264814611531e-05 mirMAP -0.327840754834073 2.98320621158857e-06 NA NA NA hsa-miR-590-3p IL6ST 2.59289455139753 1.03200520972022e-21 -2.09967019941458 1.93264814611531e-05 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.430331243735572 5.48902062239544e-07 NA NA NA hsa-miR-590-5p IL6ST 3.18300989862077 2.06813568597893e-26 -2.09967019941458 1.93264814611531e-05 mirMAP -0.501515554818375 3.82688344406144e-11 NA NA NA hsa-miR-592 IL6ST 1.51765968871077 0.000636335248013204 -2.09967019941458 1.93264814611531e-05 PITA -0.163013657370531 0.00287944571693164 NA NA NA hsa-miR-625-3p IL6ST 1.18769734290812 2.47200238827911e-06 -2.09967019941458 1.93264814611531e-05 mirMAP -0.186973056420345 0.048544062594472 NA NA NA hsa-miR-629-3p IL6ST 2.36570947321815 1.33458201201618e-11 -2.09967019941458 1.93264814611531e-05 miRNATAP -0.213410631274733 0.00486066766431223 NA NA NA hsa-miR-664a-3p IL6ST 0.634721925861133 0.00520070178640421 -2.09967019941458 1.93264814611531e-05 mirMAP -0.585743710844392 2.17334713534325e-08 NA NA NA hsa-miR-7-1-3p IL6ST 1.84950311431067 1.25300363397654e-13 -2.09967019941458 1.93264814611531e-05 mirMAP -0.427762922658735 4.24846764694316e-06 NA NA NA hsa-miR-708-3p IL6ST 2.80907765282502 3.07460722669281e-14 -2.09967019941458 1.93264814611531e-05 mirMAP -0.217249457718473 0.000529528832841992 NA NA NA hsa-miR-93-3p IL6ST 2.85383869771942 5.64481766902125e-23 -2.09967019941458 1.93264814611531e-05 MirTarget -0.638552351577972 4.14947045034708e-17 NA NA NA hsa-miR-944 IL6ST 2.91186649218281 1.31574753528144e-06 -2.09967019941458 1.93264814611531e-05 mirMAP -0.171696315905015 2.09944275144152e-05 NA NA NA hsa-miR-126-5p IL7 0.895338176458417 2.33372756450713e-05 -0.911814562072489 0.00593853142002263 mirMAP -0.183223096233096 0.0159832188215214 NA NA NA hsa-miR-192-5p IL7 2.69002528723195 1.22990188194432e-16 -0.911814562072489 0.00593853142002263 miRNAWalker2_validate -0.250002092588449 1.12337201771153e-07 NA NA NA hsa-miR-215-5p IL7 2.30755467422978 2.38476032118039e-06 -0.911814562072489 0.00593853142002263 miRNAWalker2_validate -0.106369371171006 0.00144995776024937 NA NA NA hsa-miR-335-3p IL7 3.08791651139852 5.31309869723517e-12 -0.911814562072489 0.00593853142002263 mirMAP -0.228749088974194 2.2128548626284e-11 NA NA NA hsa-miR-335-5p IL7 1.77247705492746 2.22457658872091e-06 -0.911814562072489 0.00593853142002263 miRNAWalker2_validate -0.226914161492099 6.05873766223422e-08 NA NA NA hsa-miR-429 IL7 4.48815175680773 2.44117492218206e-17 -0.911814562072489 0.00593853142002263 miRanda -0.132768744973272 4.22861280358326e-06 NA NA NA hsa-miR-542-3p IL7 1.18832665895751 1.98700670691565e-07 -0.911814562072489 0.00593853142002263 miRanda -0.306181619758953 1.01457752215632e-05 NA NA NA hsa-miR-125a-5p IL7R 0.599529391575274 0.0102300147180307 -1.05033388888472 0.0658543700402536 miRanda -0.70343309526522 1.80486059514543e-09 NA NA NA hsa-miR-129-5p IL7R -0.524170159980738 0.222582956006346 -1.05033388888472 0.0658543700402536 miRanda;mirMAP -0.159763515609224 0.0149914100365471 NA NA NA hsa-miR-181c-5p IL7R 1.58587920618301 1.57506918816933e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.496371141599136 5.05532021358559e-06 NA NA NA hsa-miR-26b-5p IL7R 0.885393662798425 3.2116297961629e-06 -1.05033388888472 0.0658543700402536 miRNAWalker2_validate -0.309468489953212 0.0338128004203917 NA NA NA hsa-miR-3065-5p IL7R 2.74629919868982 1.86846589298284e-08 -1.05033388888472 0.0658543700402536 mirMAP -0.303894968324891 7.17685947412129e-06 NA NA NA hsa-miR-330-3p IL7R 0.876747334239085 0.00073709016089703 -1.05033388888472 0.0658543700402536 miRNATAP -0.503498227571291 1.78992992142017e-06 NA NA NA hsa-miR-335-3p IL7R 3.08791651139852 5.31309869723517e-12 -1.05033388888472 0.0658543700402536 mirMAP -0.274186508929196 4.22202008391783e-06 NA NA NA hsa-miR-450b-5p IL7R 1.69244418548325 1.68064054148881e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.225810857440466 0.0278018805715008 NA NA NA hsa-miR-501-5p IL7R 1.93654809410041 1.3779381780759e-10 -1.05033388888472 0.0658543700402536 mirMAP -0.280190017844517 0.00242876728641734 NA NA NA hsa-miR-508-3p IL7R 1.05493034310846 0.0393857095042515 -1.05033388888472 0.0658543700402536 mirMAP -0.141480471119692 0.0102247623467109 NA NA NA hsa-miR-576-5p IL7R 2.20467023993664 3.4053475193793e-19 -1.05033388888472 0.0658543700402536 mirMAP -0.425928935231224 7.31668657168399e-05 NA NA NA hsa-miR-7-1-3p IL7R 1.84950311431067 1.25300363397654e-13 -1.05033388888472 0.0658543700402536 mirMAP -0.311333751551424 0.00392955547080483 NA NA NA hsa-miR-106b-5p IRF9 2.46782146831112 1.36171495805632e-23 0.439522407399987 0.038519050332205 miRNAWalker2_validate -0.110595120951475 0.00520614271830354 NA NA NA hsa-let-7g-3p JAK1 3.26398061402445 3.96263126107645e-25 -0.647144039203939 3.25551149817466e-06 MirTarget -0.160173599472765 1.98343469212566e-15 NA NA NA hsa-miR-106a-5p JAK1 2.48882002962836 1.99757727374521e-12 -0.647144039203939 3.25551149817466e-06 MirTarget -0.133261991596329 2.08270266659009e-13 NA NA NA hsa-miR-106b-5p JAK1 2.46782146831112 1.36171495805632e-23 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate;MirTarget -0.270448677438555 1.81937362986755e-28 NA NA NA hsa-miR-128-3p JAK1 1.63756041666078 6.79626586407187e-14 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate -0.23450814388999 1.21522000897489e-15 NA NA NA hsa-miR-15b-5p JAK1 1.57112623124278 9.14247846750597e-13 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate -0.202388635992569 6.7540767380457e-12 NA NA NA hsa-miR-17-5p JAK1 3.2710598467455 9.93128340539455e-27 -0.647144039203939 3.25551149817466e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.190095912387356 9.24241683512841e-22 NA NA NA hsa-miR-20a-5p JAK1 3.15577933619191 4.19753346442454e-25 -0.647144039203939 3.25551149817466e-06 MirTarget -0.19658594535312 5.11615429760049e-23 NA NA NA hsa-miR-28-5p JAK1 0.230152919654905 0.0742909586754846 -0.647144039203939 3.25551149817466e-06 miRanda;miRNATAP -0.170979664648501 0.00160634337684464 NA NA NA hsa-miR-30b-5p JAK1 0.800822374912712 0.000133601914525413 -0.647144039203939 3.25551149817466e-06 MirTarget -0.161576536892966 4.64284555422181e-07 NA NA NA hsa-miR-30c-5p JAK1 0.778774633108 0.000285599212429136 -0.647144039203939 3.25551149817466e-06 MirTarget -0.201102336728054 8.89538183624433e-11 NA NA NA hsa-miR-30d-5p JAK1 0.675423997639582 0.00270618816039773 -0.647144039203939 3.25551149817466e-06 MirTarget -0.154865436420283 2.14924883319783e-07 NA NA NA hsa-miR-30e-5p JAK1 1.23904909539663 1.35561917122157e-09 -0.647144039203939 3.25551149817466e-06 MirTarget -0.230082866037824 6.16026755354551e-13 NA NA NA hsa-miR-421 JAK1 1.17791565395543 6.78526676976629e-06 -0.647144039203939 3.25551149817466e-06 miRanda -0.147691711558544 6.10849726240234e-09 NA NA NA hsa-miR-93-5p JAK1 3.03961860136032 1.11672209617395e-24 -0.647144039203939 3.25551149817466e-06 MirTarget;miRNATAP -0.231847990523344 8.3596082797108e-31 NA NA NA hsa-miR-181b-5p JAK2 2.49307679431293 3.92829250217627e-20 -1.15591014116351 2.41377836157725e-06 mirMAP -0.126298321939292 0.00280279169548862 NA NA NA hsa-miR-320a JAK2 0.438165828017084 0.0390159073347133 -1.15591014116351 2.41377836157725e-06 miRanda -0.261791495849082 3.53850703335005e-06 NA NA NA hsa-miR-320b JAK2 1.55692969039548 1.41071034251915e-08 -1.15591014116351 2.41377836157725e-06 miRanda -0.192414825001941 6.78364550897638e-06 NA NA NA hsa-miR-335-5p JAK2 1.77247705492746 2.22457658872091e-06 -1.15591014116351 2.41377836157725e-06 miRNAWalker2_validate -0.139827980201026 8.49568099995058e-06 NA NA NA hsa-miR-337-3p JAK2 -0.411177775367481 0.195619700046772 -1.15591014116351 2.41377836157725e-06 PITA -0.120338259347987 0.00143569843122572 NA NA NA hsa-miR-374a-5p JAK2 0.484615721953736 0.0042981729815149 -1.15591014116351 2.41377836157725e-06 mirMAP -0.216962490817654 0.00241367009160665 NA NA NA hsa-miR-7-1-3p JAK2 1.84950311431067 1.25300363397654e-13 -1.15591014116351 2.41377836157725e-06 mirMAP -0.126192940113873 0.00705546310328513 NA NA NA hsa-miR-185-3p JAK3 2.3922478518806 1.3373426768452e-14 0.239319633198264 0.412693129074947 MirTarget -0.130400514948531 0.00304758139838244 NA NA NA hsa-miR-3065-5p JAK3 2.74629919868982 1.86846589298284e-08 0.239319633198264 0.412693129074947 MirTarget;mirMAP -0.145493467816477 2.62398563869512e-05 NA NA NA hsa-miR-30b-3p JAK3 0.834142820354026 0.000972582820878813 0.239319633198264 0.412693129074947 MirTarget -0.340344181521277 6.48798336220165e-10 NA NA NA hsa-miR-320b JAK3 1.55692969039548 1.41071034251915e-08 0.239319633198264 0.412693129074947 miRanda -0.124107097041574 0.0144841788065049 NA NA NA hsa-miR-421 JAK3 1.17791565395543 6.78526676976629e-06 0.239319633198264 0.412693129074947 miRanda -0.193934751106983 0.000292909648252411 NA NA NA hsa-miR-130b-5p LEP 2.9963110846538 1.98883029416455e-18 -1.85273827130139 0.00573821996244134 mirMAP -0.29505411410632 0.00162417598730084 NA NA NA hsa-miR-27b-5p LEP 0.393316367667332 0.051702301924024 -1.85273827130139 0.00573821996244134 mirMAP -0.34699075830068 0.0331905977999438 NA NA NA hsa-miR-29b-3p LEP 1.65828197923813 1.02676780888141e-09 -1.85273827130139 0.00573821996244134 miRNATAP -0.358331965511043 0.00234810438759153 NA NA NA hsa-miR-330-3p LEP 0.876747334239085 0.00073709016089703 -1.85273827130139 0.00573821996244134 mirMAP -0.273711045781908 0.0291622048907507 NA NA NA hsa-miR-33a-3p LEP 1.72765312072219 1.51784443453521e-07 -1.85273827130139 0.00573821996244134 mirMAP -0.411631173102157 0.000118322562482761 NA NA NA hsa-miR-361-5p LEP 0.971859117235239 5.30236555707088e-09 -1.85273827130139 0.00573821996244134 mirMAP -0.655235380863867 0.000771280275833552 NA NA NA hsa-miR-590-3p LEP 2.59289455139753 1.03200520972022e-21 -1.85273827130139 0.00573821996244134 mirMAP -0.469161248985161 6.23261516422396e-05 NA NA NA hsa-let-7a-3p LEPR 1.42015538786275 7.03375209382654e-13 -2.12744323260056 3.5665835716367e-14 mirMAP -0.271113002518506 9.13287743312755e-05 NA NA NA hsa-let-7f-1-3p LEPR 1.55054488387679 7.31326775537952e-11 -2.12744323260056 3.5665835716367e-14 mirMAP -0.26609944927813 6.81844996466186e-06 NA NA NA hsa-miR-107 LEPR 1.30977326593435 1.30372468603965e-11 -2.12744323260056 3.5665835716367e-14 miRanda -0.366068596445827 2.19444529451667e-07 NA NA NA hsa-miR-126-5p LEPR 0.895338176458417 2.33372756450713e-05 -2.12744323260056 3.5665835716367e-14 mirMAP -0.220339821604981 0.000859200514466756 NA NA NA hsa-miR-130b-5p LEPR 2.9963110846538 1.98883029416455e-18 -2.12744323260056 3.5665835716367e-14 mirMAP -0.350193265955018 1.32146258845648e-19 NA NA NA hsa-miR-146b-5p LEPR 1.75587235896724 1.15724631266659e-07 -2.12744323260056 3.5665835716367e-14 miRanda -0.113976473012636 0.00633031121575147 NA NA NA hsa-miR-16-1-3p LEPR 2.56983217111073 3.02262181237943e-20 -2.12744323260056 3.5665835716367e-14 mirMAP -0.260701292910742 9.35134084805578e-08 NA NA NA hsa-miR-16-2-3p LEPR 2.31623086727196 4.29838149388188e-20 -2.12744323260056 3.5665835716367e-14 mirMAP -0.444474139067407 3.8631221828769e-18 NA NA NA hsa-miR-29a-5p LEPR 1.46749674755271 3.34605004270294e-07 -2.12744323260056 3.5665835716367e-14 mirMAP -0.139784637187892 0.00615450299177151 NA NA NA hsa-miR-320a LEPR 0.438165828017084 0.0390159073347133 -2.12744323260056 3.5665835716367e-14 miRanda -0.139029886519156 0.0371488495684245 NA NA NA hsa-miR-320b LEPR 1.55692969039548 1.41071034251915e-08 -2.12744323260056 3.5665835716367e-14 miRanda -0.216672793352074 1.49858366962403e-05 NA NA NA hsa-miR-326 LEPR 0.715313016136042 0.0610265683213359 -2.12744323260056 3.5665835716367e-14 miRanda -0.128036455334108 0.000498547117492919 NA NA NA hsa-miR-330-5p LEPR 1.15100069700871 4.85551805046014e-07 -2.12744323260056 3.5665835716367e-14 miRanda -0.287812081070877 1.86584777180135e-06 NA NA NA hsa-miR-335-3p LEPR 3.08791651139852 5.31309869723517e-12 -2.12744323260056 3.5665835716367e-14 mirMAP -0.202311751595222 1.10814327416071e-11 NA NA NA hsa-miR-335-5p LEPR 1.77247705492746 2.22457658872091e-06 -2.12744323260056 3.5665835716367e-14 miRNAWalker2_validate -0.188959683820175 2.40612389132049e-07 NA NA NA hsa-miR-33a-3p LEPR 1.72765312072219 1.51784443453521e-07 -2.12744323260056 3.5665835716367e-14 mirMAP -0.202024092590565 1.08738574217714e-05 NA NA NA hsa-miR-340-5p LEPR 0.30282999308409 0.157744789519131 -2.12744323260056 3.5665835716367e-14 mirMAP -0.175016232991835 0.00803659413986829 NA NA NA hsa-miR-342-3p LEPR 1.49115144672245 1.43879249744621e-07 -2.12744323260056 3.5665835716367e-14 miRanda -0.246846029882809 3.3231297547541e-07 NA NA NA hsa-miR-34c-3p LEPR 2.41359195938096 3.46966584087088e-10 -2.12744323260056 3.5665835716367e-14 mirMAP -0.135390201676583 0.000241749655945473 NA NA NA hsa-miR-362-3p LEPR 2.0756816987665 3.89026064579331e-12 -2.12744323260056 3.5665835716367e-14 miRanda -0.333953001326403 4.2427007818558e-13 NA NA NA hsa-miR-421 LEPR 1.17791565395543 6.78526676976629e-06 -2.12744323260056 3.5665835716367e-14 miRanda -0.286701427794054 5.29452629971926e-08 NA NA NA hsa-miR-429 LEPR 4.48815175680773 2.44117492218206e-17 -2.12744323260056 3.5665835716367e-14 miRanda;miRNATAP -0.17485208819106 1.61102498543535e-12 NA NA NA hsa-miR-576-5p LEPR 2.20467023993664 3.4053475193793e-19 -2.12744323260056 3.5665835716367e-14 PITA -0.39880327697151 6.50632896834674e-14 NA NA NA hsa-miR-590-3p LEPR 2.59289455139753 1.03200520972022e-21 -2.12744323260056 3.5665835716367e-14 miRanda;mirMAP -0.397712875655022 4.89737223453515e-16 NA NA NA hsa-miR-590-5p LEPR 3.18300989862077 2.06813568597893e-26 -2.12744323260056 3.5665835716367e-14 miRanda -0.3835321389588 1.07278748358036e-18 NA NA NA hsa-miR-660-5p LEPR 1.82692095272076 1.92040083607196e-13 -2.12744323260056 3.5665835716367e-14 MirTarget -0.36911868047446 6.81140493379141e-12 NA NA NA hsa-miR-7-1-3p LEPR 1.84950311431067 1.25300363397654e-13 -2.12744323260056 3.5665835716367e-14 mirMAP -0.358002583088227 2.39341294665083e-11 NA NA NA hsa-miR-877-5p LEPR 2.94916202082736 1.8151927276044e-13 -2.12744323260056 3.5665835716367e-14 miRNAWalker2_validate -0.279799975290776 5.72630876991385e-14 NA NA NA hsa-miR-106a-5p LIF 2.48882002962836 1.99757727374521e-12 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.182501818937697 0.000538078759637783 NA NA NA hsa-miR-106b-5p LIF 2.46782146831112 1.36171495805632e-23 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.401923245968485 3.77286711613409e-08 NA NA NA hsa-miR-141-3p LIF 5.02396127982626 2.19224509139725e-24 -1.6300990984737 3.46879078767171e-05 mirMAP -0.211882464421913 4.50278438467506e-09 NA NA NA hsa-miR-148b-5p LIF 2.18024067300781 2.84770452413262e-14 -1.6300990984737 3.46879078767171e-05 mirMAP -0.288281626411144 2.52609933238727e-05 NA NA NA hsa-miR-149-5p LIF 2.94200492826326 4.93436498919036e-14 -1.6300990984737 3.46879078767171e-05 mirMAP -0.201750969440515 2.04596612191718e-05 NA NA NA hsa-miR-17-5p LIF 3.2710598467455 9.93128340539455e-27 -1.6300990984737 3.46879078767171e-05 TargetScan;miRNATAP -0.221616621081221 0.000164927075527935 NA NA NA hsa-miR-181c-5p LIF 1.58587920618301 1.57506918816933e-10 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.248899359617983 0.00106517830832155 NA NA NA hsa-miR-18a-5p LIF 3.78535678765353 3.72446596213886e-26 -1.6300990984737 3.46879078767171e-05 MirTarget -0.151174827857038 0.00457936560428536 NA NA NA hsa-miR-19a-3p LIF 3.42309334186656 3.02671914353412e-28 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.17789558478037 0.0020897053368739 NA NA NA hsa-miR-19b-3p LIF 2.49529833021187 1.57028265846699e-23 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.233869867328301 0.00135783501816621 NA NA NA hsa-miR-200a-3p LIF 4.59434485520731 6.38952518573476e-18 -1.6300990984737 3.46879078767171e-05 mirMAP -0.202025106818065 2.73385965108106e-09 NA NA NA hsa-miR-20a-5p LIF 3.15577933619191 4.19753346442454e-25 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.199172879827757 0.000785517748355182 NA NA NA hsa-miR-20b-5p LIF 2.07706563022469 1.10107236083433e-05 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.144528375726257 0.000310717951423607 NA NA NA hsa-miR-320a LIF 0.438165828017084 0.0390159073347133 -1.6300990984737 3.46879078767171e-05 mirMAP -0.236811063725807 0.00947789073307474 NA NA NA hsa-miR-320b LIF 1.55692969039548 1.41071034251915e-08 -1.6300990984737 3.46879078767171e-05 mirMAP -0.314424783650442 4.41770674136766e-06 NA NA NA hsa-miR-324-3p LIF 2.08739139768981 3.11885987067952e-13 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.353038527811879 4.36357452034511e-08 NA NA NA hsa-miR-330-5p LIF 1.15100069700871 4.85551805046014e-07 -1.6300990984737 3.46879078767171e-05 miRNAWalker2_validate -0.204830205716259 0.0142156191506854 NA NA NA hsa-miR-335-5p LIF 1.77247705492746 2.22457658872091e-06 -1.6300990984737 3.46879078767171e-05 miRNAWalker2_validate;mirMAP -0.101898496821817 0.0448967701233439 NA NA NA hsa-miR-33a-3p LIF 1.72765312072219 1.51784443453521e-07 -1.6300990984737 3.46879078767171e-05 MirTarget -0.326551241167542 1.85735436985663e-07 NA NA NA hsa-miR-421 LIF 1.17791565395543 6.78526676976629e-06 -1.6300990984737 3.46879078767171e-05 mirMAP -0.220417891370543 0.00255998288256802 NA NA NA hsa-miR-532-3p LIF 1.96631878320218 4.53421954361695e-13 -1.6300990984737 3.46879078767171e-05 mirMAP -0.260333558059473 0.000150335807757887 NA NA NA hsa-miR-590-3p LIF 2.59289455139753 1.03200520972022e-21 -1.6300990984737 3.46879078767171e-05 miRanda -0.176125778892225 0.0113175136707714 NA NA NA hsa-miR-769-5p LIF 1.82023760596845 9.6815886564134e-14 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.468639617054085 4.67036475779434e-10 NA NA NA hsa-miR-93-5p LIF 3.03961860136032 1.11672209617395e-24 -1.6300990984737 3.46879078767171e-05 miRNATAP -0.310204730128769 3.03813310408174e-07 NA NA NA hsa-let-7a-3p LIFR 1.42015538786275 7.03375209382654e-13 -2.63259527057529 1.38063075823569e-10 mirMAP -0.368906979233308 0.000239622163211769 NA NA NA hsa-miR-125a-5p LIFR 0.599529391575274 0.0102300147180307 -2.63259527057529 1.38063075823569e-10 PITA -0.353066511590583 4.81920363330357e-05 25962054 Gain of function and loss of function of LIFR directly correlated with the inhibition and overexpression of miR-125a respectively; We further demonstrated that miR-125a influenced stem cells by regulating Hippo signaling through LIFR in human primary breast cancer cells confirming the data obtained from established cell lines breast cancer hsa-miR-128-3p LIFR 1.63756041666078 6.79626586407187e-14 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.32751180955288 0.000292862139130524 NA NA NA hsa-miR-1296-5p LIFR 1.20556568733873 8.93601534401924e-06 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.18388289729969 0.01343697996703 NA NA NA hsa-miR-136-5p LIFR 2.09637138292451 1.50140005592201e-10 -2.63259527057529 1.38063075823569e-10 mirMAP;miRNATAP -0.224510415480817 0.000206794924632257 NA NA NA hsa-miR-182-5p LIFR 3.53923166221814 5.07781258121574e-21 -2.63259527057529 1.38063075823569e-10 mirMAP -0.391394043860235 3.5767895328356e-15 NA NA NA hsa-miR-186-5p LIFR 1.47445398888668 3.0781726595413e-15 -2.63259527057529 1.38063075823569e-10 mirMAP -0.425583264925298 5.60873384948666e-05 NA NA NA hsa-miR-19a-3p LIFR 3.42309334186656 3.02671914353412e-28 -2.63259527057529 1.38063075823569e-10 mirMAP -0.341794566918764 1.42286436449525e-08 NA NA NA hsa-miR-19b-3p LIFR 2.49529833021187 1.57028265846699e-23 -2.63259527057529 1.38063075823569e-10 mirMAP -0.431872620554592 1.41774127136645e-08 NA NA NA hsa-miR-203a-3p LIFR 3.12352008343999 9.49391438647189e-07 -2.63259527057529 1.38063075823569e-10 MirTarget -0.194165976872669 2.85353767984324e-10 NA NA NA hsa-miR-205-5p LIFR 4.1389800495524 2.05488295686453e-12 -2.63259527057529 1.38063075823569e-10 mirMAP -0.324942193614301 9.19452582192744e-25 NA NA NA hsa-miR-21-5p LIFR 2.73773305747971 1.38864982139576e-43 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.452730043258809 9.01193571383607e-07 NA NA NA hsa-miR-224-3p LIFR 1.87536386559317 6.15140969394846e-05 -2.63259527057529 1.38063075823569e-10 mirMAP -0.113157073109683 0.0120362149413045 NA NA NA hsa-miR-23a-3p LIFR 1.00493340843378 2.55313889288924e-08 -2.63259527057529 1.38063075823569e-10 mirMAP -0.676602462255956 8.33562234962804e-10 NA NA NA hsa-miR-26b-5p LIFR 0.885393662798425 3.2116297961629e-06 -2.63259527057529 1.38063075823569e-10 mirMAP -0.537650211782565 3.67025742525427e-07 NA NA NA hsa-miR-27a-3p LIFR 1.66542180327138 4.93775737894805e-13 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.497697732787467 4.38679516785295e-09 NA NA NA hsa-miR-27b-3p LIFR 0.196007704287769 0.295630157035388 -2.63259527057529 1.38063075823569e-10 MirTarget;miRNATAP -0.325642645121511 0.00300387226119738 NA NA NA hsa-miR-29b-1-5p LIFR 1.55384379072167 4.76870585070176e-05 -2.63259527057529 1.38063075823569e-10 mirMAP -0.109889215851689 0.0499366685317759 NA NA NA hsa-miR-3065-5p LIFR 2.74629919868982 1.86846589298284e-08 -2.63259527057529 1.38063075823569e-10 mirMAP -0.209800588225994 2.50601446438982e-05 NA NA NA hsa-miR-30c-5p LIFR 0.778774633108 0.000285599212429136 -2.63259527057529 1.38063075823569e-10 miRNATAP -0.273703333017262 0.00387289004446486 NA NA NA hsa-miR-30d-3p LIFR 0.977747550180601 4.3048212205381e-05 -2.63259527057529 1.38063075823569e-10 mirMAP -0.293939291765172 0.000513737117341708 NA NA NA hsa-miR-30d-5p LIFR 0.675423997639582 0.00270618816039773 -2.63259527057529 1.38063075823569e-10 miRNATAP -0.334806807085619 0.000204183186239637 NA NA NA hsa-miR-32-3p LIFR 2.02436999565685 5.94091197945307e-09 -2.63259527057529 1.38063075823569e-10 mirMAP -0.174287011986277 0.00776491965250298 NA NA NA hsa-miR-320a LIFR 0.438165828017084 0.0390159073347133 -2.63259527057529 1.38063075823569e-10 miRanda -0.362817682240648 0.000157736572540311 NA NA NA hsa-miR-320b LIFR 1.55692969039548 1.41071034251915e-08 -2.63259527057529 1.38063075823569e-10 miRanda -0.309885396843237 1.91207258677968e-05 NA NA NA hsa-miR-330-3p LIFR 0.876747334239085 0.00073709016089703 -2.63259527057529 1.38063075823569e-10 mirMAP -0.340064346866705 1.16626600809627e-05 NA NA NA hsa-miR-335-3p LIFR 3.08791651139852 5.31309869723517e-12 -2.63259527057529 1.38063075823569e-10 MirTarget -0.324548095470144 3.60843330687948e-14 NA NA NA hsa-miR-335-5p LIFR 1.77247705492746 2.22457658872091e-06 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.276810251535744 1.7162625336088e-07 NA NA NA hsa-miR-3607-3p LIFR 2.68532138541128 5.66716351955047e-14 -2.63259527057529 1.38063075823569e-10 mirMAP -0.302412098599408 6.25386392575016e-08 NA NA NA hsa-miR-429 LIFR 4.48815175680773 2.44117492218206e-17 -2.63259527057529 1.38063075823569e-10 miRanda -0.295067839492349 8.27778775358093e-17 NA NA NA hsa-miR-590-3p LIFR 2.59289455139753 1.03200520972022e-21 -2.63259527057529 1.38063075823569e-10 miRanda;mirMAP -0.273609486610872 0.00018369419146287 NA NA NA hsa-miR-590-5p LIFR 3.18300989862077 2.06813568597893e-26 -2.63259527057529 1.38063075823569e-10 PITA;miRNATAP -0.366278769791441 1.42917570557918e-08 NA NA NA hsa-miR-629-3p LIFR 2.36570947321815 1.33458201201618e-11 -2.63259527057529 1.38063075823569e-10 miRNATAP -0.202188549571681 0.00158701433556124 NA NA NA hsa-miR-664a-3p LIFR 0.634721925861133 0.00520070178640421 -2.63259527057529 1.38063075823569e-10 mirMAP -0.339490115650739 0.000145954129767223 NA NA NA hsa-miR-7-1-3p LIFR 1.84950311431067 1.25300363397654e-13 -2.63259527057529 1.38063075823569e-10 mirMAP -0.208218753913561 0.00867787674836039 NA NA NA hsa-miR-708-3p LIFR 2.80907765282502 3.07460722669281e-14 -2.63259527057529 1.38063075823569e-10 mirMAP -0.150711258251468 0.00457345821742287 NA NA NA hsa-miR-940 LIFR 3.21011374578759 2.7923171128495e-14 -2.63259527057529 1.38063075823569e-10 MirTarget -0.282868023466488 1.68308519701194e-08 NA NA NA hsa-miR-944 LIFR 2.91186649218281 1.31574753528144e-06 -2.63259527057529 1.38063075823569e-10 mirMAP -0.266307204111462 1.11056034308617e-15 NA NA NA hsa-miR-96-5p LIFR 4.89433085814374 1.92000659886961e-31 -2.63259527057529 1.38063075823569e-10 mirMAP -0.375704536259938 2.32745333708395e-17 NA NA NA hsa-miR-98-5p LIFR 1.11154309866014 1.24143909012085e-08 -2.63259527057529 1.38063075823569e-10 miRNAWalker2_validate -0.518525972708098 3.94090734867525e-07 NA NA NA hsa-let-7a-5p MPL 0.618599506841644 2.76973453058748e-05 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.416563028979525 5.56794407539324e-08 NA NA NA hsa-let-7d-5p MPL 1.33236798905207 1.1741085658466e-13 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.342093386535112 2.05140547531861e-08 NA NA NA hsa-let-7e-5p MPL 0.860104282510173 6.04758298373779e-05 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.223425928962936 2.01215270315669e-05 NA NA NA hsa-let-7f-5p MPL 0.495648727272215 0.00355972741198794 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.186243696740052 0.00566490142227862 NA NA NA hsa-miR-128-3p MPL 1.63756041666078 6.79626586407187e-14 -1.58407041011234 3.41937402880313e-12 MirTarget -0.318984233465614 1.16832989950246e-10 NA NA NA hsa-miR-151a-5p MPL 2.32422038747303 2.66226949101065e-18 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate;miRTarBase -0.323041522617547 2.45795244536463e-16 NA NA NA hsa-miR-339-5p MPL 2.68710938429893 3.03134080808154e-16 -1.58407041011234 3.41937402880313e-12 miRanda -0.106558009502114 0.00128190799104349 NA NA NA hsa-miR-342-5p MPL 1.74634624752902 3.89286511372155e-11 -1.58407041011234 3.41937402880313e-12 MirTarget -0.249292823854211 1.52083295904757e-09 NA NA NA hsa-miR-455-5p MPL 2.2582442061694 1.43472128037398e-13 -1.58407041011234 3.41937402880313e-12 MirTarget;miRanda -0.195531752672223 3.5754819941582e-08 NA NA NA hsa-miR-542-3p MPL 1.18832665895751 1.98700670691565e-07 -1.58407041011234 3.41937402880313e-12 miRanda -0.117632536484027 0.0166866377557842 NA NA NA hsa-miR-625-5p MPL 1.42540152147292 1.95797147911206e-06 -1.58407041011234 3.41937402880313e-12 MirTarget -0.198090360494282 1.11234629743124e-06 NA NA NA hsa-miR-98-5p MPL 1.11154309866014 1.24143909012085e-08 -1.58407041011234 3.41937402880313e-12 miRNAWalker2_validate -0.267763166829617 2.66486548695184e-06 NA NA NA hsa-let-7f-5p MYC 0.495648727272215 0.00355972741198794 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.302610362502413 0.00593577090066522 NA NA NA hsa-let-7g-5p MYC 1.20061455355116 1.50237505511483e-12 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.647634835001101 8.67569135821405e-10 NA NA NA hsa-miR-320a MYC 0.438165828017084 0.0390159073347133 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.270203083250914 0.00203008366284758 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 1.55692969039548 1.41071034251915e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.211227042104883 0.00142753396089349 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-335-5p MYC 1.77247705492746 2.22457658872091e-06 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.15527675337735 0.00141118517916367 NA NA NA hsa-miR-34a-5p MYC 1.9016323452565 1.43092834643601e-14 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.359767953473847 5.62932761832786e-07 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-423-5p MYC 0.963563145758616 9.86109015204915e-07 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.592117097378242 1.10389937335588e-10 NA NA NA hsa-miR-429 MYC 4.48815175680773 2.44117492218206e-17 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.269400502460394 6.09134482841112e-17 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC 1.48254348878737 3.23019501613577e-09 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate -0.254793177391621 0.000439915184612437 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC 1.11154309866014 1.24143909012085e-08 -1.76968865889126 2.71829937908146e-06 miRNAWalker2_validate;miRTarBase -0.602921793997467 5.7325871539819e-11 NA NA NA hsa-miR-17-5p OSM 3.2710598467455 9.93128340539455e-27 -0.423859851564122 0.347395185940331 TargetScan -0.252314193912872 0.000157125317137299 NA NA NA hsa-miR-185-3p OSM 2.3922478518806 1.3373426768452e-14 -0.423859851564122 0.347395185940331 MirTarget -0.245449571717484 0.000296196692609095 NA NA NA hsa-miR-320a OSM 0.438165828017084 0.0390159073347133 -0.423859851564122 0.347395185940331 miRanda -0.494774486571485 1.41633992871767e-06 NA NA NA hsa-miR-320b OSM 1.55692969039548 1.41071034251915e-08 -0.423859851564122 0.347395185940331 miRanda -0.346574888269941 8.37884026211797e-06 NA NA NA hsa-miR-590-5p OSM 3.18300989862077 2.06813568597893e-26 -0.423859851564122 0.347395185940331 miRanda -0.150988345659732 0.0322801586290005 NA NA NA hsa-miR-592 OSM 1.51765968871077 0.000636335248013204 -0.423859851564122 0.347395185940331 PITA;miRNATAP -0.167625684404534 0.000729098918317137 NA NA NA hsa-let-7a-5p OSMR 0.618599506841644 2.76973453058748e-05 -1.0998277332942 0.0198562724114004 TargetScan;miRNATAP -0.435560455188278 0.00563783241553846 NA NA NA hsa-let-7d-5p OSMR 1.33236798905207 1.1741085658466e-13 -1.0998277332942 0.0198562724114004 miRNATAP -1.06827084197869 6.31274876774818e-19 NA NA NA hsa-let-7e-5p OSMR 0.860104282510173 6.04758298373779e-05 -1.0998277332942 0.0198562724114004 miRNATAP -0.654114471448548 4.44852647779445e-10 NA NA NA hsa-let-7f-5p OSMR 0.495648727272215 0.00355972741198794 -1.0998277332942 0.0198562724114004 miRNATAP -0.586100924792049 1.51731733325993e-05 NA NA NA hsa-let-7g-5p OSMR 1.20061455355116 1.50237505511483e-12 -1.0998277332942 0.0198562724114004 miRNATAP -1.34131322486179 9.42025268127223e-27 NA NA NA hsa-miR-196b-5p OSMR 1.71646270856386 4.37735885910369e-09 -1.0998277332942 0.0198562724114004 miRNATAP -0.459754615555367 1.259359786718e-09 NA NA NA hsa-miR-200b-3p OSMR 3.78235093249346 3.18343003239465e-14 -1.0998277332942 0.0198562724114004 TargetScan -0.502111510374442 1.23957799885379e-34 NA NA NA hsa-miR-335-5p OSMR 1.77247705492746 2.22457658872091e-06 -1.0998277332942 0.0198562724114004 miRNAWalker2_validate -0.418785334592353 1.1578162031017e-12 NA NA NA hsa-miR-362-3p OSMR 2.0756816987665 3.89026064579331e-12 -1.0998277332942 0.0198562724114004 miRanda -0.28487700645003 0.000213859328208725 NA NA NA hsa-miR-374a-5p OSMR 0.484615721953736 0.0042981729815149 -1.0998277332942 0.0198562724114004 mirMAP -0.488024666243276 0.000341295244550417 NA NA NA hsa-miR-429 OSMR 4.48815175680773 2.44117492218206e-17 -1.0998277332942 0.0198562724114004 miRanda;miRNATAP -0.462497233544422 1.15192786178869e-33 NA NA NA hsa-miR-542-3p OSMR 1.18832665895751 1.98700670691565e-07 -1.0998277332942 0.0198562724114004 miRanda -0.296627018520046 0.00283375508696947 NA NA NA hsa-miR-590-3p OSMR 2.59289455139753 1.03200520972022e-21 -1.0998277332942 0.0198562724114004 miRanda;mirMAP;miRNATAP -0.307225685485741 0.000195518179718753 NA NA NA hsa-miR-98-5p OSMR 1.11154309866014 1.24143909012085e-08 -1.0998277332942 0.0198562724114004 miRNAWalker2_validate -1.16917812588748 1.38043593831239e-26 NA NA NA hsa-miR-320a PIAS1 0.438165828017084 0.0390159073347133 -0.418729293611933 0.00292984750388141 miRanda -0.121903226298068 0.000153288911124725 NA NA NA hsa-miR-342-3p PIAS1 1.49115144672245 1.43879249744621e-07 -0.418729293611933 0.00292984750388141 miRanda -0.133923012065101 1.03123868615213e-08 NA NA NA hsa-miR-590-3p PIAS1 2.59289455139753 1.03200520972022e-21 -0.418729293611933 0.00292984750388141 miRanda -0.106634579542964 1.30275464980239e-05 NA NA NA hsa-miR-181a-5p PIAS2 2.29556023480783 1.8138457900616e-21 -0.4512673813275 0.0189258081423701 mirMAP -0.171768883553371 2.57746102184209e-06 NA NA NA hsa-miR-181b-5p PIAS2 2.49307679431293 3.92829250217627e-20 -0.4512673813275 0.0189258081423701 mirMAP -0.127967828653809 8.95481336274409e-05 NA NA NA hsa-miR-181c-5p PIAS2 1.58587920618301 1.57506918816933e-10 -0.4512673813275 0.0189258081423701 mirMAP -0.117025674781381 0.00148723054490626 NA NA NA hsa-miR-26b-5p PIAS2 0.885393662798425 3.2116297961629e-06 -0.4512673813275 0.0189258081423701 miRNAWalker2_validate -0.100588447397763 0.0403570353966352 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-miR-146b-3p PIM1 1.10569195233795 0.000660632782194023 -0.892248221728615 0.000729042000085614 PITA;miRNATAP -0.12999446328182 0.000940503743011654 NA NA NA hsa-miR-16-5p PIM1 1.75824877145857 1.68592440033108e-16 -0.892248221728615 0.000729042000085614 miRNAWalker2_validate;miRTarBase;miRNATAP -0.123802234803259 0.0343880510410189 NA NA NA hsa-miR-339-5p PIM1 2.68710938429893 3.03134080808154e-16 -0.892248221728615 0.000729042000085614 miRanda -0.134813187944166 0.000328465721310194 NA NA NA hsa-miR-629-3p PIM1 2.36570947321815 1.33458201201618e-11 -0.892248221728615 0.000729042000085614 miRNATAP -0.112864350317053 0.00535785200387196 NA NA NA hsa-let-7a-3p PRLR 1.42015538786275 7.03375209382654e-13 -0.790590749858476 0.188888563043757 mirMAP -0.410930934968385 0.00444831743628397 NA NA NA hsa-let-7b-3p PRLR 0.868207752019623 1.30460056774366e-05 -0.790590749858476 0.188888563043757 mirMAP -0.368318214729378 0.0118833221775601 NA NA NA hsa-let-7b-5p PRLR 0.604314269683977 0.00140009936153214 -0.790590749858476 0.188888563043757 miRNATAP -0.311530653616113 0.0450390049070614 NA NA NA hsa-miR-16-1-3p PRLR 2.56983217111073 3.02262181237943e-20 -0.790590749858476 0.188888563043757 mirMAP -0.227380496604895 0.0269629972392577 NA NA NA hsa-miR-200b-3p PRLR 3.78235093249346 3.18343003239465e-14 -0.790590749858476 0.188888563043757 mirMAP -0.122169074003695 0.0308179114598278 NA NA NA hsa-miR-200c-3p PRLR 3.50132673580082 2.42716349086937e-15 -0.790590749858476 0.188888563043757 mirMAP -0.150743243476538 0.0177144148281411 NA NA NA hsa-miR-22-5p PRLR 1.88011544159252 1.63978222572222e-16 -0.790590749858476 0.188888563043757 mirMAP -0.298102174954654 0.0161014751270785 NA NA NA hsa-miR-26b-5p PRLR 0.885393662798425 3.2116297961629e-06 -0.790590749858476 0.188888563043757 mirMAP -0.406309663249685 0.00803289230720884 NA NA NA hsa-miR-29a-5p PRLR 1.46749674755271 3.34605004270294e-07 -0.790590749858476 0.188888563043757 mirMAP -0.217340448887585 0.0405888289616366 NA NA NA hsa-miR-429 PRLR 4.48815175680773 2.44117492218206e-17 -0.790590749858476 0.188888563043757 mirMAP -0.111168957062796 0.035150274126572 NA NA NA hsa-miR-455-5p PRLR 2.2582442061694 1.43472128037398e-13 -0.790590749858476 0.188888563043757 miRanda -0.277599318349269 0.00270712336119311 NA NA NA hsa-miR-582-5p PRLR 0.609226359812689 0.032988717891497 -0.790590749858476 0.188888563043757 PITA -0.596275672219836 2.88630273165367e-09 NA NA NA hsa-miR-944 PRLR 2.91186649218281 1.31574753528144e-06 -0.790590749858476 0.188888563043757 mirMAP -0.37935134274492 1.75332303661758e-15 NA NA NA hsa-miR-181a-5p PTPN11 2.29556023480783 1.8138457900616e-21 -0.452433350411265 0.00325956478076793 miRNAWalker2_validate;miRTarBase -0.185487084256816 1.39341679605697e-10 NA NA NA hsa-miR-186-5p PTPN11 1.47445398888668 3.0781726595413e-15 -0.452433350411265 0.00325956478076793 mirMAP -0.143929471124778 0.000206640326809661 NA NA NA hsa-miR-19b-3p PTPN11 2.49529833021187 1.57028265846699e-23 -0.452433350411265 0.00325956478076793 mirMAP -0.133832285409827 1.87038395237857e-06 NA NA NA hsa-miR-30d-3p PTPN11 0.977747550180601 4.3048212205381e-05 -0.452433350411265 0.00325956478076793 mirMAP -0.101814565598371 0.0010416662764693 NA NA NA hsa-miR-660-5p PTPN11 1.82692095272076 1.92040083607196e-13 -0.452433350411265 0.00325956478076793 mirMAP -0.150622441103972 1.85298087787683e-07 NA NA NA hsa-let-7a-5p SOCS1 0.618599506841644 2.76973453058748e-05 -0.629318194430381 0.0524798142155934 TargetScan -0.524623732028849 9.31061306901633e-07 NA NA NA hsa-miR-324-5p SOCS1 2.95683728155095 1.32960514360912e-20 -0.629318194430381 0.0524798142155934 miRanda -0.142997338528533 0.00240679820899766 NA NA NA hsa-miR-331-3p SOCS1 2.28379581858927 1.99663919173155e-18 -0.629318194430381 0.0524798142155934 PITA -0.246494631617319 1.86001854394675e-05 NA NA NA hsa-miR-582-5p SOCS1 0.609226359812689 0.032988717891497 -0.629318194430381 0.0524798142155934 PITA -0.163975655823809 0.00288904547616844 NA NA NA hsa-miR-107 SOCS2 1.30977326593435 1.30372468603965e-11 -1.54257627842132 8.29642001529314e-06 miRanda -0.207921979507507 0.0159466638019614 NA NA NA hsa-miR-130b-5p SOCS2 2.9963110846538 1.98883029416455e-18 -1.54257627842132 8.29642001529314e-06 miRNATAP -0.101974263844928 0.0366130597841117 NA NA NA hsa-miR-16-1-3p SOCS2 2.56983217111073 3.02262181237943e-20 -1.54257627842132 8.29642001529314e-06 mirMAP -0.233651433574582 8.25769994813488e-05 NA NA NA hsa-miR-16-5p SOCS2 1.75824877145857 1.68592440033108e-16 -1.54257627842132 8.29642001529314e-06 miRNAWalker2_validate -0.227430585509098 0.00310674955062147 NA NA NA hsa-miR-19a-3p SOCS2 3.42309334186656 3.02671914353412e-28 -1.54257627842132 8.29642001529314e-06 mirMAP -0.112502032286179 0.0274716221949732 NA NA NA hsa-miR-320b SOCS2 1.55692969039548 1.41071034251915e-08 -1.54257627842132 8.29642001529314e-06 miRanda -0.193818413512278 0.00140195309992275 NA NA NA hsa-miR-576-5p SOCS2 2.20467023993664 3.4053475193793e-19 -1.54257627842132 8.29642001529314e-06 PITA -0.188610400714941 0.00426084614917084 NA NA NA hsa-miR-590-3p SOCS2 2.59289455139753 1.03200520972022e-21 -1.54257627842132 8.29642001529314e-06 mirMAP -0.137589096655736 0.0247089939633276 NA NA NA hsa-miR-7-1-3p SOCS2 1.84950311431067 1.25300363397654e-13 -1.54257627842132 8.29642001529314e-06 mirMAP -0.135851259389565 0.0401521192037734 NA NA NA hsa-miR-130b-5p SOCS3 2.9963110846538 1.98883029416455e-18 -2.42514814798395 1.03423974620273e-12 mirMAP -0.470326484615437 1.95790668596213e-24 NA NA NA hsa-miR-30c-5p SOCS3 0.778774633108 0.000285599212429136 -2.42514814798395 1.03423974620273e-12 miRNAWalker2_validate -0.368740889755825 2.56262585407927e-06 26707189 Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR 30c in breast cancer; Our results further showed that the level of SOCS3 expression was induced by isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p miR-30c expression; In conclusion isolinderalactone induces apoptosis in MDA-MB‑231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c breast cancer hsa-miR-339-5p SOCS3 2.68710938429893 3.03134080808154e-16 -2.42514814798395 1.03423974620273e-12 miRanda -0.286684510902335 4.54235565645281e-09 NA NA NA hsa-miR-508-3p SOCS3 1.05493034310846 0.0393857095042515 -2.42514814798395 1.03423974620273e-12 PITA -0.149754394458912 7.68862852539475e-06 NA NA NA hsa-miR-629-3p SOCS3 2.36570947321815 1.33458201201618e-11 -2.42514814798395 1.03423974620273e-12 mirMAP -0.117329799922329 0.028489509858354 NA NA NA hsa-miR-629-5p SOCS3 2.10182419359635 1.51788571125757e-15 -2.42514814798395 1.03423974620273e-12 mirMAP -0.243145296021377 8.75346139885579e-05 NA NA NA hsa-let-7i-5p SOCS4 0.412877696970403 0.00622731051981756 -0.3499734105495 0.00323916823545163 miRNATAP -0.108952606808665 0.00494118796422849 NA NA NA hsa-miR-125a-5p SOCS4 0.599529391575274 0.0102300147180307 -0.3499734105495 0.00323916823545163 PITA;miRanda;miRNATAP -0.119458667885022 1.03277082484478e-06 NA NA NA hsa-miR-125b-5p SOCS4 -1.16462950151259 0.000288900271798384 -0.3499734105495 0.00323916823545163 miRNATAP -0.101687222155386 6.32480064984314e-09 NA NA NA hsa-miR-140-3p SOCS4 0.0608890720479334 0.727716871248724 -0.3499734105495 0.00323916823545163 PITA;miRNATAP -0.112526344256814 0.000727408580736205 NA NA NA hsa-miR-21-5p SOCS4 2.73773305747971 1.38864982139576e-43 -0.3499734105495 0.00323916823545163 miRNAWalker2_validate -0.108222135460776 3.52817869913008e-05 NA NA NA hsa-let-7a-3p SOCS5 1.42015538786275 7.03375209382654e-13 -0.491967856882936 4.91892319443221e-05 mirMAP -0.133171101321446 4.24740551959135e-06 NA NA NA hsa-miR-126-5p SOCS5 0.895338176458417 2.33372756450713e-05 -0.491967856882936 4.91892319443221e-05 mirMAP -0.14533935233572 1.18809291007903e-07 NA NA NA hsa-miR-16-5p SOCS5 1.75824877145857 1.68592440033108e-16 -0.491967856882936 4.91892319443221e-05 miRNAWalker2_validate -0.158141198534927 1.85317842645401e-09 NA NA NA hsa-miR-21-5p SOCS5 2.73773305747971 1.38864982139576e-43 -0.491967856882936 4.91892319443221e-05 miRNAWalker2_validate -0.142823112988024 8.09014151494991e-08 NA NA NA hsa-miR-26b-5p SOCS5 0.885393662798425 3.2116297961629e-06 -0.491967856882936 4.91892319443221e-05 mirMAP -0.148880052616919 1.20049171578655e-06 NA NA NA hsa-miR-342-3p SOCS5 1.49115144672245 1.43879249744621e-07 -0.491967856882936 4.91892319443221e-05 miRanda -0.10710793116805 1.24058521357375e-07 NA NA NA hsa-miR-590-3p SOCS5 2.59289455139753 1.03200520972022e-21 -0.491967856882936 4.91892319443221e-05 miRanda;mirMAP -0.110678392553992 1.38930282501463e-07 NA NA NA hsa-miR-590-5p SOCS5 3.18300989862077 2.06813568597893e-26 -0.491967856882936 4.91892319443221e-05 miRanda -0.109073619612105 5.33866833003086e-09 NA NA NA hsa-miR-139-5p SOCS7 -1.52606598644743 1.20474151350665e-08 -0.0555534209434714 0.820032843957113 miRNATAP -0.104342570887653 0.0163768878341053 NA NA NA hsa-miR-145-5p SOCS7 -1.55259331973517 9.97889123247165e-07 -0.0555534209434714 0.820032843957113 miRNAWalker2_validate -0.11012761429732 0.00269551249233381 23392170 socs7 a target gene of microRNA 145 regulates interferon β induction through STAT3 nuclear translocation in bladder cancer cells; Then we focused on the suppressor of cytokine signaling 7 socs7 whose expression level was upregulated in bladder cancer cells compared with its level in normal human urothelial cells as a putative target gene involved in IFN-β induction by miR-145; Expectedly exogenous miR-145 decreased the expression level of SOCS7 and socs7-silencing enhanced IFN-β induction by transfection with a TLR3 ligand polyinosinic acid-polycytidylic acid PIC; The results of a luciferase reporter assay revealed that miR-145 targeted socs7; In conclusion the machinery of IFN-β induction through the regulation of SOCS7 by miR-145 was closely associated with the induction of apoptosis; Moreover exogenous miR-145 promoted IFN-β induction by targeting socs7 which resulted in the nuclear translocation of STAT3 bladder cancer hsa-miR-320a SOCS7 0.438165828017084 0.0390159073347133 -0.0555534209434714 0.820032843957113 PITA;miRanda -0.129439028774415 0.0209032023974165 NA NA NA hsa-miR-132-3p SOS1 0.156276992635384 0.408190812100704 -0.16498215834071 0.203173827793335 miRNATAP -0.124479028859718 0.000189720665201441 NA NA NA hsa-miR-140-3p SOS1 0.0608890720479334 0.727716871248724 -0.16498215834071 0.203173827793335 miRNATAP -0.101782613385997 0.00502361468434803 NA NA NA hsa-miR-23a-3p SOS1 1.00493340843378 2.55313889288924e-08 -0.16498215834071 0.203173827793335 mirMAP -0.129314634656678 0.000166578408604821 NA NA NA hsa-miR-26a-2-3p SOS1 0.823520019989974 0.00017092160823769 -0.16498215834071 0.203173827793335 mirMAP -0.118538447529583 3.24943288286622e-05 NA NA NA hsa-miR-27a-3p SOS1 1.66542180327138 4.93775737894805e-13 -0.16498215834071 0.203173827793335 MirTarget;miRNATAP -0.122545061941616 3.0550593865242e-06 NA NA NA hsa-miR-30a-5p SOS1 -0.878357906436456 0.000509952992366057 -0.16498215834071 0.203173827793335 mirMAP;miRNATAP -0.11057365509939 6.32062418728583e-06 NA NA NA hsa-miR-140-5p SOS2 0.844753502512594 3.73722278438606e-05 -0.541773165962052 3.38343002773895e-05 miRanda -0.175305178985449 9.75022022997209e-09 NA NA NA hsa-miR-146b-5p SOS2 1.75587235896724 1.15724631266659e-07 -0.541773165962052 3.38343002773895e-05 miRanda -0.115152479666608 5.46824888444679e-10 NA NA NA hsa-miR-15a-5p SOS2 2.34669284378787 1.69544424500258e-23 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.100823047270651 8.09178891804544e-05 NA NA NA hsa-miR-193a-3p SOS2 1.60460546928078 2.86169793322984e-07 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.115828791088816 4.45409413355469e-09 NA NA NA hsa-miR-199a-5p SOS2 0.592984035153911 0.0674836634175293 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.106315824647688 3.80818848808324e-08 NA NA NA hsa-miR-199b-5p SOS2 0.218704279044827 0.519493319158441 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.110351567625311 2.11664365720639e-09 NA NA NA hsa-miR-21-5p SOS2 2.73773305747971 1.38864982139576e-43 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.17866087041205 3.99766997060001e-10 NA NA NA hsa-miR-424-5p SOS2 1.61930224569578 1.89642549274994e-10 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.10457735471019 1.79360950512032e-05 NA NA NA hsa-miR-454-3p SOS2 2.47234127820054 1.12878018736016e-21 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.106988836200975 7.58489665683655e-06 NA NA NA hsa-miR-493-5p SOS2 0.847772103665986 0.00528678068747754 -0.541773165962052 3.38343002773895e-05 miRNATAP -0.107549440318842 2.05055453955094e-07 NA NA NA hsa-miR-590-3p SOS2 2.59289455139753 1.03200520972022e-21 -0.541773165962052 3.38343002773895e-05 miRanda;mirMAP -0.115775809148697 3.43791025032322e-07 NA NA NA hsa-miR-590-5p SOS2 3.18300989862077 2.06813568597893e-26 -0.541773165962052 3.38343002773895e-05 PITA;miRanda;miRNATAP -0.105807242898967 1.7586879655633e-07 NA NA NA hsa-miR-101-3p SPRED1 0.522819989585461 0.00375627731618038 -0.64004595524649 0.00626859347930208 miRNATAP -0.250868790569951 7.36881624477961e-05 NA NA NA hsa-miR-103a-3p SPRED1 1.44083190496858 1.53799939616416e-13 -0.64004595524649 0.00626859347930208 miRNAWalker2_validate -0.316575522829281 1.81835680934293e-08 NA NA NA hsa-miR-106a-5p SPRED1 2.48882002962836 1.99757727374521e-12 -0.64004595524649 0.00626859347930208 miRNATAP -0.182750533660742 2.71440983693664e-09 NA NA NA hsa-miR-106b-5p SPRED1 2.46782146831112 1.36171495805632e-23 -0.64004595524649 0.00626859347930208 miRNATAP -0.359583962290157 1.33661862881299e-17 NA NA NA hsa-miR-107 SPRED1 1.30977326593435 1.30372468603965e-11 -0.64004595524649 0.00626859347930208 miRanda -0.366075162564011 1.06328869784606e-10 NA NA NA hsa-miR-126-3p SPRED1 1.6384689127743 1.4473425456641e-10 -0.64004595524649 0.00626859347930208 miRNAWalker2_validate;miRTarBase;miRNATAP -0.125866361509463 0.00389645515596759 NA NA NA hsa-miR-130b-3p SPRED1 3.5350292994509 1.73934183852569e-27 -0.64004595524649 0.00626859347930208 miRNATAP -0.19751941843217 7.61392768423582e-10 NA NA NA hsa-miR-141-3p SPRED1 5.02396127982626 2.19224509139725e-24 -0.64004595524649 0.00626859347930208 miRNATAP -0.172766117206038 1.51843479785622e-16 NA NA NA hsa-miR-15a-5p SPRED1 2.34669284378787 1.69544424500258e-23 -0.64004595524649 0.00626859347930208 miRNATAP -0.126568092766082 0.00588015550578475 NA NA NA hsa-miR-15b-5p SPRED1 1.57112623124278 9.14247846750597e-13 -0.64004595524649 0.00626859347930208 miRNATAP -0.289823605190193 5.79330949902734e-09 NA NA NA hsa-miR-16-5p SPRED1 1.75824877145857 1.68592440033108e-16 -0.64004595524649 0.00626859347930208 miRNAWalker2_validate;miRNATAP -0.183660910009098 0.000361811458203944 NA NA NA hsa-miR-17-5p SPRED1 3.2710598467455 9.93128340539455e-27 -0.64004595524649 0.00626859347930208 TargetScan;miRNATAP -0.161057579475905 3.23669643956863e-06 NA NA NA hsa-miR-183-5p SPRED1 4.19757025992371 4.79612296318304e-26 -0.64004595524649 0.00626859347930208 miRNATAP -0.198362392559903 2.45030430852329e-14 NA NA NA hsa-miR-188-5p SPRED1 2.52825126596644 6.78099435999778e-14 -0.64004595524649 0.00626859347930208 PITA;miRNATAP -0.252312841982261 8.77055845952184e-14 NA NA NA hsa-miR-194-5p SPRED1 1.8992998339217 3.76507853301977e-10 -0.64004595524649 0.00626859347930208 miRNATAP -0.217346054726263 1.74103238686257e-09 NA NA NA hsa-miR-200a-3p SPRED1 4.59434485520731 6.38952518573476e-18 -0.64004595524649 0.00626859347930208 miRNATAP -0.180312628833909 2.25100379022968e-20 NA NA NA hsa-miR-200b-3p SPRED1 3.78235093249346 3.18343003239465e-14 -0.64004595524649 0.00626859347930208 TargetScan -0.192535442546002 6.35150763735835e-20 NA NA NA hsa-miR-200c-3p SPRED1 3.50132673580082 2.42716349086937e-15 -0.64004595524649 0.00626859347930208 miRNATAP -0.179812130749086 7.93557682460323e-14 NA NA NA hsa-miR-20a-5p SPRED1 3.15577933619191 4.19753346442454e-25 -0.64004595524649 0.00626859347930208 miRNATAP -0.15640535445871 7.22544183813738e-06 NA NA NA hsa-miR-20b-5p SPRED1 2.07706563022469 1.10107236083433e-05 -0.64004595524649 0.00626859347930208 miRNATAP -0.152957095205572 4.82867216433063e-11 NA NA NA hsa-miR-25-3p SPRED1 1.36472605225697 4.83790725935681e-11 -0.64004595524649 0.00626859347930208 mirMAP -0.369071670220309 2.27702423363859e-12 NA NA NA hsa-miR-26b-5p SPRED1 0.885393662798425 3.2116297961629e-06 -0.64004595524649 0.00626859347930208 miRNATAP -0.155764978793941 0.00916859969347872 NA NA NA hsa-miR-28-3p SPRED1 -0.411384408160536 0.0101470262574251 -0.64004595524649 0.00626859347930208 PITA;miRNATAP -0.149139379944831 0.0390769771604901 NA NA NA hsa-miR-301a-3p SPRED1 2.81024345929638 2.29784847962242e-17 -0.64004595524649 0.00626859347930208 miRNATAP -0.229754612691631 1.51583602326959e-11 NA NA NA hsa-miR-3065-5p SPRED1 2.74629919868982 1.86846589298284e-08 -0.64004595524649 0.00626859347930208 mirMAP -0.119600218187951 1.71707988492808e-05 NA NA NA hsa-miR-32-3p SPRED1 2.02436999565685 5.94091197945307e-09 -0.64004595524649 0.00626859347930208 mirMAP -0.217998930800408 1.35709216330918e-09 NA NA NA hsa-miR-32-5p SPRED1 2.34056473219422 6.24134585974322e-20 -0.64004595524649 0.00626859347930208 mirMAP -0.325483728024611 2.52784957498816e-15 NA NA NA hsa-miR-330-3p SPRED1 0.876747334239085 0.00073709016089703 -0.64004595524649 0.00626859347930208 mirMAP;miRNATAP -0.229969930239634 9.75403323620238e-08 NA NA NA hsa-miR-335-3p SPRED1 3.08791651139852 5.31309869723517e-12 -0.64004595524649 0.00626859347930208 mirMAP -0.101635454300859 3.41174268549143e-05 NA NA NA hsa-miR-335-5p SPRED1 1.77247705492746 2.22457658872091e-06 -0.64004595524649 0.00626859347930208 miRNAWalker2_validate -0.129446752276312 1.35478075627965e-05 NA NA NA hsa-miR-33a-3p SPRED1 1.72765312072219 1.51784443453521e-07 -0.64004595524649 0.00626859347930208 mirMAP -0.223512802679112 1.24288936671888e-09 NA NA NA hsa-miR-34a-5p SPRED1 1.9016323452565 1.43092834643601e-14 -0.64004595524649 0.00626859347930208 miRNATAP -0.255133581450969 6.6069311768714e-09 NA NA NA hsa-miR-361-5p SPRED1 0.971859117235239 5.30236555707088e-09 -0.64004595524649 0.00626859347930208 miRanda -0.31548706629733 2.95594308640416e-06 NA NA NA hsa-miR-363-3p SPRED1 1.50575300026701 0.00020976164678918 -0.64004595524649 0.00626859347930208 mirMAP -0.165787592829386 1.25931342755293e-09 NA NA NA hsa-miR-374a-5p SPRED1 0.484615721953736 0.0042981729815149 -0.64004595524649 0.00626859347930208 mirMAP -0.179714444550888 0.00802809256921052 NA NA NA hsa-miR-374b-5p SPRED1 0.0654362503857184 0.722673188879465 -0.64004595524649 0.00626859347930208 mirMAP -0.205260960765203 0.000996644199397375 NA NA NA hsa-miR-429 SPRED1 4.48815175680773 2.44117492218206e-17 -0.64004595524649 0.00626859347930208 miRNATAP -0.186577897424968 1.49259720690494e-21 NA NA NA hsa-miR-454-3p SPRED1 2.47234127820054 1.12878018736016e-21 -0.64004595524649 0.00626859347930208 miRNATAP -0.22278341190665 1.64164336913589e-07 NA NA NA hsa-miR-497-5p SPRED1 0.0257087130056286 0.918145413833358 -0.64004595524649 0.00626859347930208 miRNATAP -0.150681963227663 0.000949605529840618 NA NA NA hsa-miR-500a-5p SPRED1 1.72110365584658 3.0807246212659e-10 -0.64004595524649 0.00626859347930208 mirMAP -0.247718908054675 6.44245749028207e-10 NA NA NA hsa-miR-589-3p SPRED1 2.51971841868825 2.39125940264107e-11 -0.64004595524649 0.00626859347930208 mirMAP -0.111114129216949 0.000876571819933646 NA NA NA hsa-miR-590-3p SPRED1 2.59289455139753 1.03200520972022e-21 -0.64004595524649 0.00626859347930208 miRanda;mirMAP -0.20371447652951 5.33131064318946e-07 NA NA NA hsa-miR-664a-3p SPRED1 0.634721925861133 0.00520070178640421 -0.64004595524649 0.00626859347930208 mirMAP -0.259412501716889 1.69248553918834e-07 NA NA NA hsa-miR-92a-3p SPRED1 2.06460102658973 1.44784291084757e-19 -0.64004595524649 0.00626859347930208 mirMAP -0.206875751371883 1.3335752128038e-05 NA NA NA hsa-miR-93-3p SPRED1 2.85383869771942 5.64481766902125e-23 -0.64004595524649 0.00626859347930208 miRNATAP -0.275195969326774 2.81145245246251e-14 NA NA NA hsa-miR-93-5p SPRED1 3.03961860136032 1.11672209617395e-24 -0.64004595524649 0.00626859347930208 miRNAWalker2_validate;miRNATAP -0.258294100077331 2.21173657004928e-13 NA NA NA hsa-miR-142-5p SPRED2 1.17581605694506 0.0018174701991234 0.138405688881245 0.457735493086991 mirMAP -0.14407108589858 6.44962188457434e-10 NA NA NA hsa-miR-146b-5p SPRED2 1.75587235896724 1.15724631266659e-07 0.138405688881245 0.457735493086991 miRanda -0.206419961303893 1.58972673185089e-15 NA NA NA hsa-miR-338-3p SPRED2 0.453166438193782 0.144583389707558 0.138405688881245 0.457735493086991 miRanda -0.111824241648907 0.000107675104361448 NA NA NA hsa-miR-340-5p SPRED2 0.30282999308409 0.157744789519131 0.138405688881245 0.457735493086991 miRNATAP -0.121434297400954 0.00409569817595624 NA NA NA hsa-let-7a-3p SPRY1 1.42015538786275 7.03375209382654e-13 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.326750998870788 1.39990743219818e-07 NA NA NA hsa-let-7b-3p SPRY1 0.868207752019623 1.30460056774366e-05 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.238381689803221 0.000167231725235452 NA NA NA hsa-miR-107 SPRY1 1.30977326593435 1.30372468603965e-11 -2.18099466015105 3.38614196731148e-18 miRanda;miRNATAP -0.352218990828283 3.03766992225786e-08 NA NA NA hsa-miR-142-5p SPRY1 1.17581605694506 0.0018174701991234 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.104850936645125 0.00167257603011659 NA NA NA hsa-miR-16-2-3p SPRY1 2.31623086727196 4.29838149388188e-20 -2.18099466015105 3.38614196731148e-18 mirMAP -0.402095897466472 3.06037217812573e-18 NA NA NA hsa-miR-20a-3p SPRY1 2.92621109947706 2.49504904635375e-17 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.311988888682389 2.14570512100745e-19 NA NA NA hsa-miR-21-5p SPRY1 2.73773305747971 1.38864982139576e-43 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.422159604394367 6.91007964916414e-14 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-26b-5p SPRY1 0.885393662798425 3.2116297961629e-06 -2.18099466015105 3.38614196731148e-18 miRNAWalker2_validate -0.259949208766523 8.791451161485e-05 NA NA NA hsa-miR-29b-3p SPRY1 1.65828197923813 1.02676780888141e-09 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.242490928720967 8.30319588459694e-08 NA NA NA hsa-miR-324-3p SPRY1 2.08739139768981 3.11885987067952e-13 -2.18099466015105 3.38614196731148e-18 miRNAWalker2_validate -0.258338917089908 9.82885695352689e-10 NA NA NA hsa-miR-339-5p SPRY1 2.68710938429893 3.03134080808154e-16 -2.18099466015105 3.38614196731148e-18 miRanda -0.292028225654537 3.78400394041929e-16 NA NA NA hsa-miR-34c-5p SPRY1 2.07190852984647 7.35776320806257e-08 -2.18099466015105 3.38614196731148e-18 miRanda -0.103522431988016 0.00270382174372133 NA NA NA hsa-miR-3615 SPRY1 2.22631608637736 1.11307777062266e-16 -2.18099466015105 3.38614196731148e-18 miRNAWalker2_validate -0.335784510408731 1.58997743803826e-13 NA NA NA hsa-miR-421 SPRY1 1.17791565395543 6.78526676976629e-06 -2.18099466015105 3.38614196731148e-18 PITA;miRanda;miRNATAP -0.227575081646817 1.85878692610667e-06 NA NA NA hsa-miR-455-3p SPRY1 3.06093594997644 3.54590649799868e-16 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.245214509127913 6.61416691089379e-15 NA NA NA hsa-miR-550a-3p SPRY1 1.78308792532884 2.47673569057582e-07 -2.18099466015105 3.38614196731148e-18 miRNATAP -0.267963132185494 2.36554789623623e-11 NA NA NA hsa-miR-590-5p SPRY1 3.18300989862077 2.06813568597893e-26 -2.18099466015105 3.38614196731148e-18 PITA;miRanda;miRNATAP -0.351876333396077 2.42127402993648e-19 NA NA NA hsa-miR-98-5p SPRY1 1.11154309866014 1.24143909012085e-08 -2.18099466015105 3.38614196731148e-18 miRNAWalker2_validate -0.322538510658975 4.12926580224683e-07 NA NA NA hsa-let-7a-3p SPRY2 1.42015538786275 7.03375209382654e-13 -1.56677647796773 2.28758561626214e-07 miRNATAP -0.159454398636675 0.0308892012807276 NA NA NA hsa-let-7b-3p SPRY2 0.868207752019623 1.30460056774366e-05 -1.56677647796773 2.28758561626214e-07 miRNATAP -0.163955906107462 0.0283525170642765 NA NA NA hsa-miR-148a-3p SPRY2 1.26728238710376 2.52325607402829e-06 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate -0.138147925228463 0.0116832538888583 NA NA NA hsa-miR-181a-5p SPRY2 2.29556023480783 1.8138457900616e-21 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate -0.131191731454816 0.0260037188855004 NA NA NA hsa-miR-21-5p SPRY2 2.73773305747971 1.38864982139576e-43 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.293552101879134 1.42915082637336e-05 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-27a-3p SPRY2 1.66542180327138 4.93775737894805e-13 -1.56677647796773 2.28758561626214e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.131511034966349 0.0373243156859752 20638779 By using a reporter-screening assay we discovered that the 3'UTR of Sprouty2 Spry2 carried a putative miR-27a binding site; Furthermore the Spry2 protein which has a low expression level in pancreatic adenocarcinoma was upregulated by transfection with a miR-27a inhibitor; The data reported here are the first to indicate that miR-27a plays an oncogenic role by targeting Spry2 and modulating the malignant biological behavior of pancreatic cancer cells malignant trasformation pancreatic cancer hsa-miR-326 SPRY2 0.715313016136042 0.0610265683213359 -1.56677647796773 2.28758561626214e-07 miRanda;miRNATAP -0.1988144651405 2.65654161630311e-07 NA NA NA hsa-miR-330-5p SPRY2 1.15100069700871 4.85551805046014e-07 -1.56677647796773 2.28758561626214e-07 miRanda;miRNATAP -0.238730845891666 0.000204738921064239 NA NA NA hsa-miR-369-3p SPRY2 0.946781510019564 0.00134850306966842 -1.56677647796773 2.28758561626214e-07 miRNATAP -0.112998978861705 0.0249340487702443 NA NA NA hsa-miR-374b-5p SPRY2 0.0654362503857184 0.722673188879465 -1.56677647796773 2.28758561626214e-07 mirMAP;miRNATAP -0.282682627303184 0.000528200440540266 NA NA NA hsa-miR-429 SPRY2 4.48815175680773 2.44117492218206e-17 -1.56677647796773 2.28758561626214e-07 miRanda -0.109821099297924 3.98906467298285e-05 NA NA NA hsa-miR-590-3p SPRY2 2.59289455139753 1.03200520972022e-21 -1.56677647796773 2.28758561626214e-07 PITA;miRanda;mirMAP;miRNATAP -0.275012966495044 2.2537618212996e-07 NA NA NA hsa-miR-590-5p SPRY2 3.18300989862077 2.06813568597893e-26 -1.56677647796773 2.28758561626214e-07 PITA;miRanda;miRNATAP -0.272789623553336 7.69009009350228e-09 NA NA NA hsa-miR-1271-5p SPRY3 0.970418832993172 0.000609742584380688 -0.0910411948898686 0.670326378214004 MirTarget -0.115604169674007 0.00149139960057221 NA NA NA hsa-miR-146b-5p SPRY3 1.75587235896724 1.15724631266659e-07 -0.0910411948898686 0.670326378214004 mirMAP -0.142426655829734 2.93123879932714e-06 NA NA NA hsa-miR-155-5p SPRY3 1.20164021433135 0.00086170622431261 -0.0910411948898686 0.670326378214004 mirMAP -0.114234189479215 5.53601044643755e-05 NA NA NA hsa-miR-382-5p SPRY3 0.545586518720593 0.0621058523772996 -0.0910411948898686 0.670326378214004 mirMAP -0.121926565261892 0.000545795392065795 NA NA NA hsa-miR-485-3p SPRY3 0.442820096243914 0.166634696770945 -0.0910411948898686 0.670326378214004 mirMAP -0.114633770285535 0.000416470516404253 NA NA NA hsa-miR-29c-3p SPRY4 -0.00968972577705429 0.97099586346872 0.237505661867377 0.34038136065999 miRNATAP -0.10173520010268 0.0252532612148053 NA NA NA hsa-miR-140-5p STAM2 0.844753502512594 3.73722278438606e-05 -0.459002176084125 0.000119908684750531 miRanda -0.104305895330426 0.000212445330453972 NA NA NA hsa-miR-186-5p STAM2 1.47445398888668 3.0781726595413e-15 -0.459002176084125 0.000119908684750531 mirMAP -0.137450033853436 4.63600444117931e-06 NA NA NA hsa-miR-25-3p STAM2 1.36472605225697 4.83790725935681e-11 -0.459002176084125 0.000119908684750531 mirMAP -0.108363415750165 7.34399926156665e-05 NA NA NA hsa-miR-362-3p STAM2 2.0756816987665 3.89026064579331e-12 -0.459002176084125 0.000119908684750531 miRanda -0.113733710145517 3.13514641232192e-09 NA NA NA hsa-miR-92a-3p STAM2 2.06460102658973 1.44784291084757e-19 -0.459002176084125 0.000119908684750531 mirMAP -0.112898037351722 2.98086642219729e-06 NA NA NA hsa-miR-92b-3p STAM2 1.20409245530001 3.41055816361655e-06 -0.459002176084125 0.000119908684750531 mirMAP -0.116180339339533 1.11339428836818e-07 NA NA NA hsa-miR-10b-3p STAT1 0.77597971642517 0.00264877454133753 0.542663454678779 0.0737713250641883 mirMAP -0.144010470092659 0.0114736344207079 NA NA NA hsa-miR-129-5p STAT1 -0.524170159980738 0.222582956006346 0.542663454678779 0.0737713250641883 miRanda -0.130838629073018 0.00016350335642995 NA NA NA hsa-miR-182-5p STAT1 3.53923166221814 5.07781258121574e-21 0.542663454678779 0.0737713250641883 mirMAP -0.163334442311918 9.45184839156753e-06 NA NA NA hsa-miR-30c-2-3p STAT1 -1.66877185449987 3.97071129111399e-10 0.542663454678779 0.0737713250641883 MirTarget -0.12575068666197 0.0202459461290519 NA NA NA hsa-miR-34a-5p STAT1 1.9016323452565 1.43092834643601e-14 0.542663454678779 0.0737713250641883 miRNAWalker2_validate -0.236831607684438 3.76320893148253e-05 NA NA NA hsa-miR-361-5p STAT1 0.971859117235239 5.30236555707088e-09 0.542663454678779 0.0737713250641883 miRanda -0.470459202481732 6.26819932873564e-08 NA NA NA hsa-miR-532-3p STAT1 1.96631878320218 4.53421954361695e-13 0.542663454678779 0.0737713250641883 MirTarget -0.121327246883262 0.0214988933745161 NA NA NA hsa-miR-96-5p STAT1 4.89433085814374 1.92000659886961e-31 0.542663454678779 0.0737713250641883 mirMAP -0.124523927373397 0.000173012373283214 NA NA NA hsa-let-7a-5p STAT3 0.618599506841644 2.76973453058748e-05 -0.539456513473352 0.0002104451396002 TargetScan -0.101606108325329 0.0367516203828481 24491408 MicroRNA let 7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression; We demonstrate in this study that re-expression of let-7 in poorly-differentiated PDAC cell lines reduced phosphorylation/activation of STAT3 and its downstream signaling events and reduced the growth and migration of PDAC cells; Our study thus identified a mechanism by which STAT3 signaling can be inhibited in pancreatic cancer cells by modifying let-7 expression pancreatic cancer hsa-let-7e-5p STAT3 0.860104282510173 6.04758298373779e-05 -0.539456513473352 0.0002104451396002 miRNAWalker2_validate -0.205243706272178 2.18916625094902e-10 NA NA NA hsa-miR-106a-5p STAT3 2.48882002962836 1.99757727374521e-12 -0.539456513473352 0.0002104451396002 miRNATAP -0.104487317381686 5.1411814156043e-08 27510094;27325313 Furthermore the present study revealed that IL-6 inhibited miR-106a expression by activating STAT3;We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression ; ovarian cancer;breast cancer hsa-miR-106b-5p STAT3 2.46782146831112 1.36171495805632e-23 -0.539456513473352 0.0002104451396002 miRNATAP -0.272534245151771 1.86165106135572e-26 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-125a-5p STAT3 0.599529391575274 0.0102300147180307 -0.539456513473352 0.0002104451396002 PITA;miRanda -0.229908411174338 5.88632762561847e-15 26389681;26878391 MiR 125a suppresses tumor growth invasion and metastasis in cervical cancer by targeting STAT3; Dual luciferase assays identified the STAT3 gene as a novel direct target of miR-125a; Functional studies showed that miR-125a overexpression significantly suppressed the growth invasion and epithelial-mesenchymal transition EMT of cervical cancer cells both in vitro and in vivo via decreasing STAT3 expression; Clinically STAT3 the expression of which predicted poorer outcome was inversely correlated with miR-125a in cervical cancer;MiR 125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression; Moreover we determined that miR-125a increased paclitaxel and cisplatin sensitivity by downregulating STAT3 metastasis; cervical and endocervical cancer;cervical and endocervical cancer hsa-miR-17-5p STAT3 3.2710598467455 9.93128340539455e-27 -0.539456513473352 0.0002104451396002 TargetScan;miRNATAP -0.153619382216393 3.70668511274473e-13 NA NA NA hsa-miR-20a-5p STAT3 3.15577933619191 4.19753346442454e-25 -0.539456513473352 0.0002104451396002 miRNAWalker2_validate;miRNATAP -0.156874868776121 1.60590044858534e-13 NA NA NA hsa-miR-320a STAT3 0.438165828017084 0.0390159073347133 -0.539456513473352 0.0002104451396002 miRanda -0.243570817492622 8.02447691597339e-14 NA NA NA hsa-miR-320b STAT3 1.55692969039548 1.41071034251915e-08 -0.539456513473352 0.0002104451396002 miRanda -0.155576493457998 4.27063083782904e-10 NA NA NA hsa-miR-429 STAT3 4.48815175680773 2.44117492218206e-17 -0.539456513473352 0.0002104451396002 miRNATAP -0.112404010663114 3.66218994672475e-20 NA NA NA hsa-miR-590-5p STAT3 3.18300989862077 2.06813568597893e-26 -0.539456513473352 0.0002104451396002 miRanda;miRNATAP -0.147911480905754 3.4501067625191e-11 27757042 We found that the AKT/ERK and STAT3 signaling pathways were activated by miR-590-5p overexpression gastric cancer hsa-miR-92a-3p STAT3 2.06460102658973 1.44784291084757e-19 -0.539456513473352 0.0002104451396002 miRNAWalker2_validate -0.203743231663503 2.31121136472559e-12 23820254 STAT3 upregulates miR 92a to inhibit RECK expression and to promote invasiveness of lung cancer cells; We demonstrate that STAT3 upregulates miR-92a to repress RECK via post-transcriptional inhibition lung cancer hsa-miR-93-5p STAT3 3.03961860136032 1.11672209617395e-24 -0.539456513473352 0.0002104451396002 miRNAWalker2_validate;miRNATAP -0.222439847909065 1.03455000217369e-25 NA NA NA hsa-miR-125a-5p STAT4 0.599529391575274 0.0102300147180307 -0.54405037149823 0.200971233130196 miRanda -0.439351239984822 5.28353047056891e-07 NA NA NA hsa-miR-141-3p STAT4 5.02396127982626 2.19224509139725e-24 -0.54405037149823 0.200971233130196 MirTarget;TargetScan -0.226416599746781 4.86462094089995e-09 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 4.59434485520731 6.38952518573476e-18 -0.54405037149823 0.200971233130196 MirTarget -0.281988734392366 3.47813349611205e-15 NA NA NA hsa-miR-29b-2-5p STAT4 0.910668640983475 0.00666655585493488 -0.54405037149823 0.200971233130196 MirTarget -0.401207611440171 2.17204453912617e-11 NA NA NA hsa-miR-320a STAT4 0.438165828017084 0.0390159073347133 -0.54405037149823 0.200971233130196 MirTarget;PITA;miRanda -0.330515393144479 0.000696737233188982 NA NA NA hsa-miR-320b STAT4 1.55692969039548 1.41071034251915e-08 -0.54405037149823 0.200971233130196 MirTarget;PITA;miRanda -0.276859178575455 0.000170325078235152 NA NA NA hsa-miR-421 STAT4 1.17791565395543 6.78526676976629e-06 -0.54405037149823 0.200971233130196 miRanda -0.317397245043162 4.62403653558738e-05 NA NA NA hsa-miR-141-3p STAT5A 5.02396127982626 2.19224509139725e-24 -0.684955697233733 0.000967420523261131 MirTarget;TargetScan;miRNATAP -0.106493543449922 2.02111667301054e-08 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-141-5p STAT5A 3.81419396518882 3.21977359736126e-18 -0.684955697233733 0.000967420523261131 MirTarget -0.122888406028399 1.49198766849939e-08 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-185-5p STAT5A 2.34016206907488 1.17481626642022e-26 -0.684955697233733 0.000967420523261131 MirTarget -0.153447548533036 0.000400042125118462 NA NA NA hsa-miR-200a-3p STAT5A 4.59434485520731 6.38952518573476e-18 -0.684955697233733 0.000967420523261131 MirTarget;miRNATAP -0.10286127919918 8.13511628453254e-09 NA NA NA hsa-miR-421 STAT5A 1.17791565395543 6.78526676976629e-06 -0.684955697233733 0.000967420523261131 miRanda -0.133252223798297 0.00049641167924963 NA NA NA hsa-miR-125a-3p STAT5B 1.24490295132072 5.26925231010328e-06 -0.990804883627709 4.43844816522907e-17 miRanda -0.124738970669333 3.58041921001941e-09 NA NA NA hsa-miR-185-3p STAT5B 2.3922478518806 1.3373426768452e-14 -0.990804883627709 4.43844816522907e-17 MirTarget -0.110913506377404 9.02526459307755e-10 NA NA NA hsa-miR-20a-3p STAT5B 2.92621109947706 2.49504904635375e-17 -0.990804883627709 4.43844816522907e-17 miRNATAP -0.104007663175011 3.431453265093e-10 NA NA NA hsa-miR-21-3p STAT5B 2.19296355304364 4.63665722759779e-15 -0.990804883627709 4.43844816522907e-17 MirTarget -0.165172611972005 5.50754804411704e-17 NA NA NA hsa-miR-23a-3p STAT5B 1.00493340843378 2.55313889288924e-08 -0.990804883627709 4.43844816522907e-17 MirTarget;miRNATAP -0.275991361244556 1.24932683967945e-18 NA NA NA hsa-miR-590-3p STAT5B 2.59289455139753 1.03200520972022e-21 -0.990804883627709 4.43844816522907e-17 miRanda -0.165627873726947 1.08702800635038e-15 NA NA NA hsa-miR-93-3p STAT5B 2.85383869771942 5.64481766902125e-23 -0.990804883627709 4.43844816522907e-17 miRNAWalker2_validate -0.136820730602574 4.26319180167194e-13 NA NA NA hsa-miR-107 STAT6 1.30977326593435 1.30372468603965e-11 -0.584015948755583 0.000691198312821435 miRanda -0.143937770622147 0.000698602093966649 NA NA NA hsa-miR-496 STAT6 0.46914638405371 0.145980484291736 -0.584015948755583 0.000691198312821435 miRanda -0.116556123101735 9.59531941035748e-06 NA NA NA hsa-miR-590-3p STAT6 2.59289455139753 1.03200520972022e-21 -0.584015948755583 0.000691198312821435 miRanda -0.102338171490737 0.000684023819985785 NA NA NA hsa-miR-590-5p STAT6 3.18300989862077 2.06813568597893e-26 -0.584015948755583 0.000691198312821435 miRanda -0.101705526162888 0.0001523681416689 NA NA NA hsa-miR-125a-3p TPO 1.24490295132072 5.26925231010328e-06 -3.30855685294499 1.08060007223916e-09 miRanda -0.489264836698808 3.8997534661197e-07 NA NA NA hsa-miR-130b-5p TPO 2.9963110846538 1.98883029416455e-18 -3.30855685294499 1.08060007223916e-09 mirMAP -0.649887947315084 1.79954314590286e-18 NA NA NA hsa-miR-19a-3p TPO 3.42309334186656 3.02671914353412e-28 -3.30855685294499 1.08060007223916e-09 mirMAP -0.563335452433584 8.12554392671255e-13 NA NA NA hsa-miR-19b-3p TPO 2.49529833021187 1.57028265846699e-23 -3.30855685294499 1.08060007223916e-09 mirMAP -0.75751893185285 1.97866249618314e-14 NA NA NA hsa-miR-25-3p TPO 1.36472605225697 4.83790725935681e-11 -3.30855685294499 1.08060007223916e-09 mirMAP -0.734003693947589 4.67050154917956e-09 NA NA NA hsa-miR-26b-5p TPO 0.885393662798425 3.2116297961629e-06 -3.30855685294499 1.08060007223916e-09 miRNAWalker2_validate -0.908165416787748 4.92621670486716e-11 NA NA NA hsa-miR-29a-5p TPO 1.46749674755271 3.34605004270294e-07 -3.30855685294499 1.08060007223916e-09 mirMAP -0.481858154324721 5.99044967786236e-07 NA NA NA hsa-miR-29c-3p TPO -0.00968972577705429 0.97099586346872 -3.30855685294499 1.08060007223916e-09 mirMAP -0.214657728653742 0.0341230853114386 NA NA NA hsa-miR-30d-3p TPO 0.977747550180601 4.3048212205381e-05 -3.30855685294499 1.08060007223916e-09 mirMAP -0.683727274634816 5.07998800160578e-10 NA NA NA hsa-miR-30e-3p TPO -0.215663037684509 0.235375122783546 -3.30855685294499 1.08060007223916e-09 mirMAP -0.576016336260877 0.000110564502413573 NA NA NA hsa-miR-32-5p TPO 2.34056473219422 6.24134585974322e-20 -3.30855685294499 1.08060007223916e-09 mirMAP -0.719207100661884 1.72133451040092e-13 NA NA NA hsa-miR-335-3p TPO 3.08791651139852 5.31309869723517e-12 -3.30855685294499 1.08060007223916e-09 mirMAP -0.258449382675102 7.80915290839784e-06 NA NA NA hsa-miR-335-5p TPO 1.77247705492746 2.22457658872091e-06 -3.30855685294499 1.08060007223916e-09 miRNAWalker2_validate -0.19081321765362 0.0069825439356222 NA NA NA hsa-miR-33a-3p TPO 1.72765312072219 1.51784443453521e-07 -3.30855685294499 1.08060007223916e-09 mirMAP -0.637169581826326 1.25057671756038e-13 NA NA NA hsa-miR-450b-5p TPO 1.69244418548325 1.68064054148881e-10 -3.30855685294499 1.08060007223916e-09 mirMAP -0.366465379640655 0.000213136797919071 NA NA NA hsa-miR-590-3p TPO 2.59289455139753 1.03200520972022e-21 -3.30855685294499 1.08060007223916e-09 miRanda -0.712609777233018 3.76833252503939e-14 NA NA NA hsa-miR-7-1-3p TPO 1.84950311431067 1.25300363397654e-13 -3.30855685294499 1.08060007223916e-09 mirMAP -0.733321579619993 6.57662985213921e-13 NA NA NA hsa-miR-92a-3p TPO 2.06460102658973 1.44784291084757e-19 -3.30855685294499 1.08060007223916e-09 mirMAP -1.0360221226088 5.38997109069844e-22 NA NA NA hsa-miR-92b-3p TPO 1.20409245530001 3.41055816361655e-06 -3.30855685294499 1.08060007223916e-09 mirMAP -0.315101228991529 0.00212789693322536 NA NA NA hsa-let-7f-1-3p TSLP 1.55054488387679 7.31326775537952e-11 -2.78747550539602 1.51140552873854e-10 MirTarget -0.388755637594705 1.9228327860527e-05 NA NA NA hsa-miR-125a-5p TSLP 0.599529391575274 0.0102300147180307 -2.78747550539602 1.51140552873854e-10 miRanda -0.312152448177977 0.000734800081133321 NA NA NA hsa-miR-142-3p TSLP 2.75247908790621 1.45636065474764e-12 -2.78747550539602 1.51140552873854e-10 miRanda -0.165855708596981 0.00205316803963982 NA NA NA hsa-miR-29a-5p TSLP 1.46749674755271 3.34605004270294e-07 -2.78747550539602 1.51140552873854e-10 mirMAP -0.208341478473289 0.0078835725998818 NA NA NA hsa-miR-335-5p TSLP 1.77247705492746 2.22457658872091e-06 -2.78747550539602 1.51140552873854e-10 miRNAWalker2_validate -0.116046010458441 0.0416066236951436 NA NA NA hsa-miR-33a-3p TSLP 1.72765312072219 1.51784443453521e-07 -2.78747550539602 1.51140552873854e-10 mirMAP -0.165054737609319 0.020328343480976 NA NA NA hsa-miR-491-5p TSLP 0.615770352820862 0.0418295628761654 -2.78747550539602 1.51140552873854e-10 miRanda -0.201406550595709 0.00846554227781519 NA NA NA hsa-miR-590-3p TSLP 2.59289455139753 1.03200520972022e-21 -2.78747550539602 1.51140552873854e-10 miRanda;mirMAP -0.380850154886959 7.93499358512746e-07 NA NA NA