miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-29b-3p	ABCB6	0.178522712044526	0.0856106432164969	0.0950771071516092	0.0631184322646142	MirTarget	-0.125080378613903	8.16612068754798e-11		NA	NA	NA
hsa-miR-29b-3p	ABL1	0.178522712044526	0.0856106432164969	-0.0143957445246219	0.802818620463732	miRNATAP	-0.183750024397894	1.77278201614351e-25		NA	NA	NA
hsa-miR-29b-3p	ABL2	0.178522712044526	0.0856106432164969	0.121408178274312	0.0131084313787502	mirMAP	-0.126285697212704	1.46552980939032e-13		NA	NA	NA
hsa-miR-29b-3p	ADAM22	0.178522712044526	0.0856106432164969	0.216502142888531	0.0463918103826042	miRNATAP	-0.206026999719274	3.50503000648477e-05		NA	NA	NA
hsa-miR-29b-3p	ADAMTS10	0.178522712044526	0.0856106432164969	-0.062343363220644	0.349725011978311	MirTarget;miRNATAP	-0.128564851338791	1.3331552357477e-05		NA	NA	NA
hsa-miR-29b-3p	ADAMTS17	0.178522712044526	0.0856106432164969	0.212825134232814	0.0312854397317146	MirTarget;miRNATAP	-0.182890855940017	8.35348016909242e-05		NA	NA	NA
hsa-miR-29b-3p	ADAMTS6	0.178522712044526	0.0856106432164969	-0.11823335399784	0.240230761835988	MirTarget;miRNATAP	-0.486359825406179	6.38247705786089e-28		NA	NA	NA
hsa-miR-29b-3p	ADAMTS7	0.178522712044526	0.0856106432164969	-0.766328671906749	1.52518550238978e-09	MirTarget;miRNATAP	-0.230821854691046	0.000142046295291264		NA	NA	NA
hsa-miR-29b-3p	ADAMTS9	0.178522712044526	0.0856106432164969	0.106172409496749	0.315532193383009	miRNATAP	-0.25497874806207	1.32209519163338e-07		NA	NA	NA
hsa-miR-29b-3p	ADCYAP1R1	0.178522712044526	0.0856106432164969	0.800922402046162	1.45739406832672e-07	miRNATAP	-0.193323773039207	0.00634973960790346		NA	NA	NA
hsa-miR-29b-3p	ADM2	0.178522712044526	0.0856106432164969	-0.690071693181486	2.66769717356179e-07	mirMAP	-0.158292460358588	0.0133173336794113		NA	NA	NA
hsa-miR-29b-3p	AFF4	0.178522712044526	0.0856106432164969	0.0476854167636862	0.414573175783937	miRNATAP	-0.109934647257619	2.50019576697111e-08		NA	NA	NA
hsa-miR-29b-3p	AKAP13	0.178522712044526	0.0856106432164969	-0.0854748245852885	0.142976880881264	MirTarget;miRNATAP	-0.125192121304385	9.4348587994469e-10		NA	NA	NA
hsa-miR-29b-3p	AMMECR1	0.178522712044526	0.0856106432164969	-0.110861997069305	0.0201013947226924	miRNATAP	-0.16227830008775	6.73849622793305e-15		NA	NA	NA
hsa-miR-29b-3p	AMMECR1L	0.178522712044526	0.0856106432164969	-0.0911269362931151	0.0250020885715883	MirTarget;miRNATAP	-0.172622038104878	1.08477523362789e-46		NA	NA	NA
hsa-miR-29b-3p	ANKRD13B	0.178522712044526	0.0856106432164969	0.09350950710144	0.144667246095611	MirTarget;miRNATAP	-0.198435291436061	6.32697976044468e-14		NA	NA	NA
hsa-miR-29b-3p	ARHGAP19	0.178522712044526	0.0856106432164969	-0.033080629260998	0.4824973670959	mirMAP	-0.153802598659857	1.64266220231822e-18		NA	NA	NA
hsa-miR-29b-3p	ARID3A	0.178522712044526	0.0856106432164969	-0.238492889401192	6.2645818227838e-05	mirMAP	-0.131946108796791	2.29127632435188e-06		NA	NA	NA
hsa-miR-29b-3p	ARRDC3	0.178522712044526	0.0856106432164969	-0.119441275627876	0.0481493321948708	MirTarget;miRNATAP	-0.101093095999512	3.72670440275566e-05		NA	NA	NA
hsa-miR-29b-3p	ARVCF	0.178522712044526	0.0856106432164969	0.133739238881019	0.0189713722563656	MirTarget;miRNATAP	-0.161096490799808	2.86128396781482e-12		NA	NA	NA
hsa-miR-29b-3p	ATAD2B	0.178522712044526	0.0856106432164969	-0.0689850013062943	0.176557202332977	MirTarget;miRNATAP	-0.235539413225567	5.58179049522192e-31		NA	NA	NA
hsa-miR-29b-3p	ATP7A	0.178522712044526	0.0856106432164969	-0.184487372472536	0.000248451749718449	miRNATAP	-0.119097388590247	1.16687169957881e-07		NA	NA	NA
hsa-miR-29b-3p	BACH2	0.178522712044526	0.0856106432164969	-0.0602438347948135	0.321808916892776	MirTarget;miRNATAP	-0.195266302642621	1.46535979487146e-12		NA	NA	NA
hsa-miR-29b-3p	BIRC6	0.178522712044526	0.0856106432164969	0.117438319325281	0.0535070751292439	miRNATAP	-0.127158812856145	3.58206512496388e-08		NA	NA	NA
hsa-miR-29b-3p	BLMH	0.178522712044526	0.0856106432164969	-0.120774973962207	0.0101687057547469	MirTarget;miRNATAP	-0.168364618078164	2.23145228799651e-25		NA	NA	NA
hsa-miR-29b-3p	BMF	0.178522712044526	0.0856106432164969	-0.429207608696316	1.2633548549993e-05	MirTarget;miRNATAP	-0.261748906677521	6.2138523830105e-09		NA	NA	NA
hsa-miR-29b-3p	BMP1	0.178522712044526	0.0856106432164969	-0.297830750099207	3.28896004201451e-07	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.215676251259133	1.59824261692691e-18		NA	NA	NA
hsa-miR-29b-3p	BRD3	0.178522712044526	0.0856106432164969	0.0836010545289021	0.142766152755558	miRNATAP	-0.207783633779319	1.21176748199316e-25		NA	NA	NA
hsa-miR-29b-3p	BRWD3	0.178522712044526	0.0856106432164969	-0.0657156290378187	0.490671662785856	MirTarget;miRNATAP	-0.35865677402749	7.34496044253421e-17		NA	NA	NA
hsa-miR-29b-3p	BTBD7	0.178522712044526	0.0856106432164969	0.0922451654757266	0.0701227729159683	miRNATAP	-0.120916616089551	5.38825898239609e-10		NA	NA	NA
hsa-miR-29b-3p	C16orf87	0.178522712044526	0.0856106432164969	-0.10845158001981	0.0279392712204476	mirMAP;miRNATAP	-0.193087979134682	4.65520861940205e-21		NA	NA	NA
hsa-miR-29b-3p	C1QTNF6	0.178522712044526	0.0856106432164969	-0.320652151333454	1.18875033445207e-05	miRNATAP	-0.263105157680744	1.58736931729358e-15		NA	NA	NA
hsa-miR-29b-3p	CACNG4	0.178522712044526	0.0856106432164969	0.0565977417868204	0.657305628641464	miRNATAP	-0.503912045246371	8.66194514969124e-20		NA	NA	NA
hsa-miR-29b-3p	CASZ1	0.178522712044526	0.0856106432164969	-0.0601215020409915	0.599142890192472	miRNATAP	-0.1951199526554	0.000252655925142684		NA	NA	NA
hsa-miR-29b-3p	CBX2	0.178522712044526	0.0856106432164969	-0.576976611077839	6.41977541080135e-08	miRNATAP	-0.433750689414563	4.06655371161798e-19		NA	NA	NA
hsa-miR-29b-3p	CBX5	0.178522712044526	0.0856106432164969	-0.0567845519185131	0.319982363494469	miRNATAP	-0.145793279563732	2.80526001435826e-19		NA	NA	NA
hsa-miR-29b-3p	CBX8	0.178522712044526	0.0856106432164969	-0.238951325951775	1.74839338174665e-07	mirMAP	-0.153987751907047	4.72256511270956e-15		NA	NA	NA
hsa-miR-29b-3p	CCDC117	0.178522712044526	0.0856106432164969	0.0284032373210419	0.513220038090182	MirTarget;miRNATAP	-0.111294470631584	7.65754902863637e-12		NA	NA	NA
hsa-miR-29b-3p	CCNA2	0.178522712044526	0.0856106432164969	-1.13046163382069	6.27502244010349e-22	MirTarget	-0.398844731810031	1.81500387990034e-12		NA	NA	NA
hsa-miR-29b-3p	CCND1	0.178522712044526	0.0856106432164969	-0.517304800763465	1.04046594178981e-06	mirMAP	-0.30608004962895	3.25721913642118e-11		NA	NA	NA
hsa-miR-29b-3p	CCND2	0.178522712044526	0.0856106432164969	-0.278072058804779	0.00230941164668829	MirTarget;miRNATAP	-0.202303651104096	1.45292987304036e-07	22330340;24130168	In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC	;	sarcoma;gastric cancer
hsa-miR-29b-3p	CCNJ	0.178522712044526	0.0856106432164969	-0.0389526035961101	0.444862190729241	MirTarget	-0.24485365327711	1.54178526337355e-31		NA	NA	NA
hsa-miR-29b-3p	CD276	0.178522712044526	0.0856106432164969	-0.460031392457725	1.14859333750124e-10	MirTarget;miRNATAP	-0.184498828016106	9.66342034925476e-10		NA	NA	NA
hsa-miR-29b-3p	CD93	0.178522712044526	0.0856106432164969	-0.974726675983549	3.04076842126384e-15	MirTarget	-0.251746200853006	1.6547909259036e-05		NA	NA	NA
hsa-miR-29b-3p	CDC42SE1	0.178522712044526	0.0856106432164969	-0.094499767362918	0.0593404701940004	MirTarget	-0.125041800171899	9.5231365914675e-17		NA	NA	NA
hsa-miR-29b-3p	CDCA4	0.178522712044526	0.0856106432164969	-0.519788534136363	1.65789931084722e-14	MirTarget	-0.260708542626711	1.03413414490813e-16		NA	NA	NA
hsa-miR-29b-3p	CDK6	0.178522712044526	0.0856106432164969	-0.514594252893815	5.86679673505726e-06	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.269230638368595	2.03842569918004e-07	26180082;23245396;25472644;23591808;27230400;20086245	Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL	;;;;;	glioblastoma;melanoma;colorectal cancer;lung cancer;sarcoma;lymphoma
hsa-miR-29b-3p	CECR2	0.178522712044526	0.0856106432164969	0.206100044750302	0.0244458090054591	miRNAWalker2_validate	-0.3643298040379	2.60261141976852e-19		NA	NA	NA
hsa-miR-29b-3p	CLCN5	0.178522712044526	0.0856106432164969	-0.107852734561221	0.0202687689909699	miRNATAP	-0.136299884336767	4.34308175676573e-12		NA	NA	NA
hsa-miR-29b-3p	CLK2	0.178522712044526	0.0856106432164969	-0.026475941874029	0.560848433653381	MirTarget;miRNATAP	-0.119003710600203	3.5622815764666e-13		NA	NA	NA
hsa-miR-29b-3p	COL1A1	0.178522712044526	0.0856106432164969	-1.23998298011726	1.14065510873326e-09	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.240566016816269	0.013638416803868		NA	NA	NA
hsa-miR-29b-3p	COL1A2	0.178522712044526	0.0856106432164969	-0.945719713706377	9.33034616922931e-13	miRNATAP	-0.132216735022061	0.0354371604112984		NA	NA	NA
hsa-miR-29b-3p	COL2A1	0.178522712044526	0.0856106432164969	-0.746239231739607	0.000374266306664833	MirTarget;miRNATAP	-0.319053515243603	0.00134322220471127		NA	NA	NA
hsa-miR-29b-3p	COL3A1	0.178522712044526	0.0856106432164969	-1.43331954235497	3.86186762290792e-13	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.441692040144896	2.96263104275717e-06		NA	NA	NA
hsa-miR-29b-3p	COL4A1	0.178522712044526	0.0856106432164969	-1.37431841954318	3.47482076751264e-19	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.351360819517442	1.87672188936429e-06		NA	NA	NA
hsa-miR-29b-3p	COL4A2	0.178522712044526	0.0856106432164969	-1.2072627458492	7.43650937308373e-19	miRTarBase;MirTarget;miRNATAP	-0.242498314795871	0.000195424997065481		NA	NA	NA
hsa-miR-29b-3p	COL4A4	0.178522712044526	0.0856106432164969	0.00930206723822424	0.937042673353122	MirTarget;miRNATAP	-0.227807945311952	3.618034191508e-05		NA	NA	NA
hsa-miR-29b-3p	COL7A1	0.178522712044526	0.0856106432164969	0.0119552123998039	0.933387720013512	MirTarget;miRNATAP	-0.264524781110266	7.44113232227426e-05		NA	NA	NA
hsa-miR-29b-3p	COL9A1	0.178522712044526	0.0856106432164969	-0.283407980094397	0.172011189594717	miRNATAP	-0.230253131193879	0.0192725852620381		NA	NA	NA
hsa-miR-29b-3p	COMMD2	0.178522712044526	0.0856106432164969	-0.0888036042290388	0.0618946419827693	MirTarget;miRNATAP	-0.143784333442063	1.05547316596734e-17		NA	NA	NA
hsa-miR-29b-3p	COQ5	0.178522712044526	0.0856106432164969	-0.0337634829358953	0.40527040055301	MirTarget	-0.100556378048226	7.85658723153289e-13		NA	NA	NA
hsa-miR-29b-3p	CRISPLD1	0.178522712044526	0.0856106432164969	-0.53924772879056	1.6065360345774e-08	MirTarget;miRNATAP	-0.230171209724304	1.12911276738085e-07		NA	NA	NA
hsa-miR-29b-3p	CTDSPL2	0.178522712044526	0.0856106432164969	-0.088200946839029	0.0990105899270895	MirTarget	-0.153293675670641	8.46633258252542e-13		NA	NA	NA
hsa-miR-29b-3p	CTNND1	0.178522712044526	0.0856106432164969	-0.137478249588692	0.0175226468508423	miRNATAP	-0.126828894776865	2.58216478646997e-13		NA	NA	NA
hsa-miR-29b-3p	DCAF12	0.178522712044526	0.0856106432164969	-0.0527404424938593	0.332367385305703	miRNATAP	-0.177733979413463	4.86262383629165e-20		NA	NA	NA
hsa-miR-29b-3p	DCAF5	0.178522712044526	0.0856106432164969	0.161559921955914	0.000874583515225249	miRNATAP	-0.102994294570304	1.34784191602669e-10		NA	NA	NA
hsa-miR-29b-3p	DCAF7	0.178522712044526	0.0856106432164969	-0.00329453129039958	0.955075596903533	MirTarget;miRNATAP	-0.200780892113579	1.11670329166221e-33		NA	NA	NA
hsa-miR-29b-3p	DCX	0.178522712044526	0.0856106432164969	0.353023955881512	0.02121596285056	MirTarget;miRNATAP	-0.592765010200952	7.45621110020549e-18		NA	NA	NA
hsa-miR-29b-3p	DDX46	0.178522712044526	0.0856106432164969	-0.0315503656932679	0.488750946194916	MirTarget	-0.119469129279307	1.50448898239071e-17		NA	NA	NA
hsa-miR-29b-3p	DENND1B	0.178522712044526	0.0856106432164969	-0.0267689461473797	0.687765599611461	miRNATAP	-0.140597989052932	5.85932139078405e-06		NA	NA	NA
hsa-miR-29b-3p	DGCR2	0.178522712044526	0.0856106432164969	0.247369614049857	0.000271508930034843	mirMAP	-0.151563774732168	3.4254741115644e-11		NA	NA	NA
hsa-miR-29b-3p	DGKD	0.178522712044526	0.0856106432164969	0.0560736158762953	0.293827582725653	MirTarget;miRNATAP	-0.151111859239459	1.71334268285151e-14		NA	NA	NA
hsa-miR-29b-3p	DLGAP1	0.178522712044526	0.0856106432164969	0.619150050487183	1.95461189677499e-07	miRNATAP	-0.126671678833714	0.0214177958226168		NA	NA	NA
hsa-miR-29b-3p	DNMT1	0.178522712044526	0.0856106432164969	-0.327836453121988	2.01022847518227e-08	miRNAWalker2_validate;miRTarBase	-0.195900239412499	1.22026545223089e-19	21625215	MiRNA-dependent regulation of MEG3 expression was studied by evaluating the involvement of miR-29 which can modulate DNMT 1 and 3		liver cancer
hsa-miR-29b-3p	DNMT3A	0.178522712044526	0.0856106432164969	-0.271329340511704	5.83997401502433e-07	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.117466495338086	8.81022584889031e-07	23939044;26171207;24798303;26471361;25874772;17890317;22479643;25746661	The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;In addition a significant inverse correlation was identified between the expression levels of DNMT3A and miR-29b in estrogen receptor-positive breast cancer patients P=0.027;Consistent with miR-29's role in targeting DNA methyltransferase 3A DNMT3A a key enzyme regulating DNA methylation we found a significant inverse correlation P<0.001 between miR-29 and DNMT3A gene expression suggesting that they might be functionally antagonistic;Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;The de-regulation of the miR-29 family and DNA methyltransferase 3A DNMT3A is associated with gastric cancer GC;Among the reported down-regulated miRNAs in lung cancer the miRNA miR-29 family 29a 29b and 29c has intriguing complementarities to the 3'-UTRs of DNA methyltransferase DNMT3A and -3B de novo methyltransferases two key enzymes involved in DNA methylation that are frequently up-regulated in lung cancer and associated with poor prognosis;The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability;DNMT3A and 3B genes can be regulated post-transcriptionally by miR-29 family	;;;;;worse prognosis;;	lung squamous cell cancer;breast cancer;liver cancer;bladder cancer;gastric cancer;lung cancer;ovarian cancer;lymphoma
hsa-miR-29b-3p	DNMT3B	0.178522712044526	0.0856106432164969	-0.329990452550479	3.82769193230854e-07	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.261009962921483	3.34579090070212e-18	23939044;26404322;22479643	The miR-29 family miR-29a -29b and -29c which negatively regulates DNMT3A and DNMT3B was examined in association with the Wnt/β-catenin signaling pathway; The expression of miR-29a and miR-29b was partially regulated by DNMT3A and DNMT3B in a positive feedback loop;The induction of miR-29b was accompanied with suppression of its downstream target DNMT3B in a dose-dependent manner; The reduction of luciferase activity of DNMT3B 3'-UTR reporter by fucoidan was as markedly as that by miR-29b mimic indicating that fucoidan induced miR-29b to suppress DNMT3B;The miR-29 family and predicted target genes were among the most strongly anti-correlated miRNA:mRNA pairs; over-expression of miR-29a in vitro repressed several anti-correlated genes including DNMT3A and DNMT3B and substantially decreased ovarian cancer cell viability	;;	lung squamous cell cancer;liver cancer;ovarian cancer
hsa-miR-29b-3p	DOLPP1	0.178522712044526	0.0856106432164969	-0.0535563221950079	0.199565148251567	MirTarget;miRNATAP	-0.105882285462942	2.66602506861781e-12		NA	NA	NA
hsa-miR-29b-3p	DOT1L	0.178522712044526	0.0856106432164969	-0.202194801055887	0.00986576414664023	MirTarget;miRNATAP	-0.361363066207971	3.49128598639317e-29		NA	NA	NA
hsa-miR-29b-3p	DPYSL3	0.178522712044526	0.0856106432164969	0.0976827098968158	0.229803497266026	MirTarget	-0.257714552456067	1.74163464119058e-21		NA	NA	NA
hsa-miR-29b-3p	DTX4	0.178522712044526	0.0856106432164969	0.315400806941909	0.000142661170822504	miRNATAP	-0.104218336483811	0.00401395036753591		NA	NA	NA
hsa-miR-29b-3p	DYNLT1	0.178522712044526	0.0856106432164969	-0.209857417082336	0.000632846447156105	miRNATAP	-0.216647183691461	8.34550475554943e-18		NA	NA	NA
hsa-miR-29b-3p	E2F7	0.178522712044526	0.0856106432164969	-1.46591745821464	2.03279508197687e-19	miRNATAP	-0.38667553714616	1.07276841145582e-06	22330340	In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator		sarcoma
hsa-miR-29b-3p	EDC3	0.178522712044526	0.0856106432164969	0.0289569598332013	0.520188007025546	MirTarget;miRNATAP	-0.150474219591452	1.50698199213975e-24		NA	NA	NA
hsa-miR-29b-3p	ELF2	0.178522712044526	0.0856106432164969	-0.070364817728815	0.094706539037586	MirTarget;miRNATAP	-0.11815139693811	9.30985686048441e-15		NA	NA	NA
hsa-miR-29b-3p	ELN	0.178522712044526	0.0856106432164969	-0.531275097125962	1.31485435936948e-08	MirTarget;miRNATAP	-0.200776001405244	2.55735732667149e-06		NA	NA	NA
hsa-miR-29b-3p	EML4	0.178522712044526	0.0856106432164969	-0.288332771137819	4.47982597276691e-08	MirTarget;miRNATAP	-0.145976520824694	3.91222228866359e-12		NA	NA	NA
hsa-miR-29b-3p	EPHB3	0.178522712044526	0.0856106432164969	-0.188459946665946	0.0154449806440299	miRNATAP	-0.291030626202406	1.882337380488e-18		NA	NA	NA
hsa-miR-29b-3p	FLVCR2	0.178522712044526	0.0856106432164969	0.108519138686137	0.275063037708549	MirTarget	-0.25220907305235	3.64498986919763e-08		NA	NA	NA
hsa-miR-29b-3p	FYN	0.178522712044526	0.0856106432164969	0.0549585477139729	0.376835504225547	miRNATAP	-0.149192808901071	5.23763462069769e-15		NA	NA	NA
hsa-miR-29b-3p	GAB1	0.178522712044526	0.0856106432164969	-0.0446393127035574	0.474589174298465	MirTarget	-0.129594197613515	5.00191188482429e-08		NA	NA	NA
hsa-miR-29b-3p	GLIS2	0.178522712044526	0.0856106432164969	0.0222500914291031	0.736555184537767	MirTarget;miRNATAP	-0.274245223188757	2.04125198410785e-26		NA	NA	NA
hsa-miR-29b-3p	GNA13	0.178522712044526	0.0856106432164969	-0.0155836168018979	0.78966803412229	MirTarget	-0.106205755392177	7.8711509880738e-08		NA	NA	NA
hsa-miR-29b-3p	GNB4	0.178522712044526	0.0856106432164969	-0.15329756635479	0.0400115629824616	MirTarget	-0.194183700087458	2.96384607574358e-11		NA	NA	NA
hsa-miR-29b-3p	GPATCH2	0.178522712044526	0.0856106432164969	-0.0448567391647368	0.255853111790534	MirTarget	-0.132810225178644	1.11942376490451e-18		NA	NA	NA
hsa-miR-29b-3p	GPR173	0.178522712044526	0.0856106432164969	0.263951560695725	0.000622204587746625	mirMAP	-0.252360120755502	1.22524301439961e-13		NA	NA	NA
hsa-miR-29b-3p	GRIK3	0.178522712044526	0.0856106432164969	-0.125008811691334	0.214028772960219	mirMAP	-0.289437021349729	1.39388103674734e-11		NA	NA	NA
hsa-miR-29b-3p	GSK3B	0.178522712044526	0.0856106432164969	0.00812669327685001	0.891858643750624	miRTarBase;miRNATAP	-0.103024519445492	4.4831296698937e-06		NA	NA	NA
hsa-miR-29b-3p	GSTA4	0.178522712044526	0.0856106432164969	0.167196933190445	0.00164705917725826	miRNATAP	-0.150378852041465	9.03982820447863e-15		NA	NA	NA
hsa-miR-29b-3p	GTPBP1	0.178522712044526	0.0856106432164969	0.0750415989076574	0.130846511293538	mirMAP	-0.109066476809992	6.48246007894374e-13		NA	NA	NA
hsa-miR-29b-3p	HAPLN3	0.178522712044526	0.0856106432164969	-0.592706820706668	7.00221778883136e-10	MirTarget	-0.165168736198013	0.000326322074729063		NA	NA	NA
hsa-miR-29b-3p	HAS3	0.178522712044526	0.0856106432164969	-0.247740395336912	0.000303761584361874	miRNATAP	-0.226893933903621	8.97190236333966e-13		NA	NA	NA
hsa-miR-29b-3p	HDAC4	0.178522712044526	0.0856106432164969	0.391149840510754	1.11052206608839e-07	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.184582439127466	1.24002021878014e-09		NA	NA	NA
hsa-miR-29b-3p	HELZ	0.178522712044526	0.0856106432164969	-0.0163470698197088	0.755596986729348	MirTarget	-0.128848585424893	1.11028232262452e-12		NA	NA	NA
hsa-miR-29b-3p	HMCN1	0.178522712044526	0.0856106432164969	-0.231220026464169	0.023011664518363	MirTarget;miRNATAP	-0.304363498072164	1.20000705367526e-10		NA	NA	NA
hsa-miR-29b-3p	HMGCR	0.178522712044526	0.0856106432164969	0.227144202029919	0.00294010331284003	miRNATAP	-0.105142860815337	0.00127801590678889		NA	NA	NA
hsa-miR-29b-3p	HNF4G	0.178522712044526	0.0856106432164969	-0.283323065933321	0.00370658247896909	MirTarget;miRNATAP	-0.156180100955537	0.000735403764450074		NA	NA	NA
hsa-miR-29b-3p	HNRNPF	0.178522712044526	0.0856106432164969	-0.146887673089928	0.00366194444430515	miRNATAP	-0.10304462583421	2.37380408984983e-09		NA	NA	NA
hsa-miR-29b-3p	HNRNPUL1	0.178522712044526	0.0856106432164969	-0.10599706557246	0.0784701907573357	miRNATAP	-0.109454976568968	9.98173181720284e-10		NA	NA	NA
hsa-miR-29b-3p	ID1	0.178522712044526	0.0856106432164969	0.00319348611937986	0.975701410530946	MirTarget	-0.252791056370778	2.87152400363784e-08	22249264;24662327	Incubation of lung cancer cells with the Src inhibitor saracatinib led to the upregulation of several miRNAs including miR-29b which was the most highly upregulated miRNA with predicted binding to the ID1 3'-untranslated region UTR; Luciferase reporter assays confirmed direct binding of miR-29b to the ID1 3'-UTR; Expression of miR-29b suppressed ID1 levels and significantly reduced migration and invasion;Id 1 a protein repressed by miR 29b facilitates the TGFβ1 induced epithelial mesenchymal transition in human ovarian cancer cells	;	lung cancer;ovarian cancer
hsa-miR-29b-3p	IGF1R	0.178522712044526	0.0856106432164969	0.135857700793022	0.0366015528395556	mirMAP	-0.114732262376249	8.64287684380274e-06		NA	NA	NA
hsa-miR-29b-3p	ILDR2	0.178522712044526	0.0856106432164969	-0.208448493330057	0.120153392779657	MirTarget	-0.284745056503761	5.77792380929968e-06		NA	NA	NA
hsa-miR-29b-3p	ISG20L2	0.178522712044526	0.0856106432164969	-0.152210033425853	0.000473407129736936	MirTarget	-0.135900131689559	5.18375309845218e-18		NA	NA	NA
hsa-miR-29b-3p	JARID2	0.178522712044526	0.0856106432164969	0.144576744320227	0.00609383758086017	MirTarget;miRNATAP	-0.124485683640416	1.93830374969058e-10		NA	NA	NA
hsa-miR-29b-3p	KCTD15	0.178522712044526	0.0856106432164969	0.0191650279824209	0.74647964464113	MirTarget;miRNATAP	-0.149380674054444	1.99664091710364e-11		NA	NA	NA
hsa-miR-29b-3p	KCTD20	0.178522712044526	0.0856106432164969	0.0460879111132364	0.494277491947324	MirTarget	-0.171971267347973	1.35539205880034e-11		NA	NA	NA
hsa-miR-29b-3p	KCTD3	0.178522712044526	0.0856106432164969	0.0174487511794634	0.741479911645445	miRNATAP	-0.145513226747021	2.14585292941747e-18		NA	NA	NA
hsa-miR-29b-3p	KCTD5	0.178522712044526	0.0856106432164969	-0.073359214360722	0.125123632704781	MirTarget;miRNATAP	-0.190503105341287	4.29476844139545e-38		NA	NA	NA
hsa-miR-29b-3p	KDELC1	0.178522712044526	0.0856106432164969	-0.308052289905702	7.10432003676237e-07	miRNATAP	-0.284821615161299	6.08810561596684e-25		NA	NA	NA
hsa-miR-29b-3p	KDM5A	0.178522712044526	0.0856106432164969	-0.131384250448589	0.0298876799606062	miRNATAP	-0.159548042502443	1.81786008796645e-11		NA	NA	NA
hsa-miR-29b-3p	KDM5B	0.178522712044526	0.0856106432164969	0.00258719218091308	0.965934728413275	MirTarget	-0.232837973002936	1.83607451783055e-27		NA	NA	NA
hsa-miR-29b-3p	KDM6B	0.178522712044526	0.0856106432164969	-0.0219062076546948	0.723247496763323	miRNATAP	-0.249424478766368	2.17771852910745e-26		NA	NA	NA
hsa-miR-29b-3p	KIAA0895L	0.178522712044526	0.0856106432164969	0.208145582530341	0.00973684696381084	MirTarget;miRNATAP	-0.192840142632951	2.82304259630333e-08		NA	NA	NA
hsa-miR-29b-3p	KIAA1549	0.178522712044526	0.0856106432164969	0.178378099422084	0.018208150660529	miRNATAP	-0.266109952545918	3.78496587002399e-18		NA	NA	NA
hsa-miR-29b-3p	KIF21B	0.178522712044526	0.0856106432164969	0.573854345014333	2.33448492326745e-09	mirMAP	-0.144656456144891	0.00060619376596517		NA	NA	NA
hsa-miR-29b-3p	KIF26A	0.178522712044526	0.0856106432164969	0.200241144097274	0.12210757001743	miRNATAP	-0.537644843203033	1.31060963700781e-20		NA	NA	NA
hsa-miR-29b-3p	KIF26B	0.178522712044526	0.0856106432164969	-0.364291628656814	0.00285301171172206	miRNATAP	-0.142625054832027	0.0137885509128585		NA	NA	NA
hsa-miR-29b-3p	KLHL25	0.178522712044526	0.0856106432164969	0.415763242889651	6.85295415260577e-08	MirTarget	-0.29646852471004	9.25783664776359e-21		NA	NA	NA
hsa-miR-29b-3p	LAMC1	0.178522712044526	0.0856106432164969	-0.643575172906647	1.88021715964262e-13	MirTarget;miRNATAP	-0.146551772207787	0.000218138367082483		NA	NA	NA
hsa-miR-29b-3p	LDOC1L	0.178522712044526	0.0856106432164969	0.182045592497999	0.00267869612506782	MirTarget;miRNATAP	-0.143402105423521	2.85469455286826e-11		NA	NA	NA
hsa-miR-29b-3p	LIF	0.178522712044526	0.0856106432164969	-1.17272538294774	4.1576768520385e-12	MirTarget;miRNATAP	-0.172815579181043	0.0349322254785942		NA	NA	NA
hsa-miR-29b-3p	LIMS1	0.178522712044526	0.0856106432164969	-0.197815718091865	0.0202387619873416	MirTarget;miRNATAP	-0.161477800718387	3.37531297287543e-05		NA	NA	NA
hsa-miR-29b-3p	LMX1A	0.178522712044526	0.0856106432164969	0.8535826520379	0.000674129994829114	miRNATAP	-0.41192030341473	0.000537296475115902		NA	NA	NA
hsa-miR-29b-3p	LPL	0.178522712044526	0.0856106432164969	0.694477187643104	1.38607318559547e-06	miRNATAP	-0.197453062044708	0.00213516033253326		NA	NA	NA
hsa-miR-29b-3p	LRCH3	0.178522712044526	0.0856106432164969	-0.0756383799820077	0.215591128602342	mirMAP	-0.220533408439029	1.88705243102843e-17		NA	NA	NA
hsa-miR-29b-3p	LRP6	0.178522712044526	0.0856106432164969	0.0635985031970643	0.303319357390934	miRNATAP	-0.151746485432759	4.07659481720806e-10		NA	NA	NA
hsa-miR-29b-3p	MAFB	0.178522712044526	0.0856106432164969	0.114209459435268	0.200239372859389	miRNATAP	-0.10167422415302	0.0100842369015608		NA	NA	NA
hsa-miR-29b-3p	MAPRE1	0.178522712044526	0.0856106432164969	-0.0643232652215051	0.236023314226219	MirTarget	-0.17318617401755	9.30033454945175e-28		NA	NA	NA
hsa-miR-29b-3p	MARCH1	0.178522712044526	0.0856106432164969	0.10296913925285	0.223369754059237	miRNATAP	-0.126302984641541	0.00109668737857933		NA	NA	NA
hsa-miR-29b-3p	MAZ	0.178522712044526	0.0856106432164969	-0.0361938613589867	0.545385462466551	miRNATAP	-0.134933110311697	1.23415428684061e-11		NA	NA	NA
hsa-miR-29b-3p	MCL1	0.178522712044526	0.0856106432164969	-0.139308533735542	0.0460458083970209	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.103132847543244	2.35612101999683e-05	24155920;20041405;25472644;27063186;19850741;24992675	Finally miR-29a and miR-29b targeted MCL1 mRNA in GICs and increased apoptosis;Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29;Moreover miR-29b inhibited the expression of MCL1 and CDK6;miR 29b and miR 198 overexpression in CD8+ T cells of renal cell carcinoma patients down modulates JAK3 and MCL 1 leading to immune dysfunction; In particular JAK3 and MCL-1 were down-regulated in patient CD8+ T cells versus their normal counterparts likely due to defective suppressor activity of miR-29b and miR-198 in RCC CD8+ T cells; Indeed specific inhibition of miR-29b or miR-198 in peripheral blood mononuclear cells PBMCs isolated from RCC patients resulted in the up-regulation of JAK3 and MCL-1 proteins and significant improvement of cell survival in vitro;A significant enrichment for apoptosis genes including MCL-1 was found among the mRNAs inversely correlated with miR-29b expression in 45 primary AML samples;BAG3 upregulates Mcl 1 through downregulation of miR 29b to induce anticancer drug resistance in ovarian cancer; Upregulation of miR-29b also reduced levels of Mcl-1 and sensitized ES2 cells to low-dose paclitaxel; BAG3 knockdown appears to downregulate expression of Mcl-1 through upregulation of miR-29b thereby increasing the chemosensitivity of ovarian clear cell carcinoma cells	;;;poor survival;;drug resistance	glioblastoma;liver cancer;colorectal cancer;kidney renal cell cancer;acute myeloid leukemia;ovarian cancer
hsa-miR-29b-3p	MED26	0.178522712044526	0.0856106432164969	-0.083297380436504	0.0172495546437219	miRNATAP	-0.102057765737652	2.51662807824565e-16		NA	NA	NA
hsa-miR-29b-3p	MEST	0.178522712044526	0.0856106432164969	-0.577340808103821	7.5694260374867e-10	MirTarget;miRNATAP	-0.313049454846683	1.13546327314225e-13		NA	NA	NA
hsa-miR-29b-3p	MEX3B	0.178522712044526	0.0856106432164969	0.140935143659144	0.156890871593976	miRNATAP	-0.388285209384615	3.15630355186925e-18		NA	NA	NA
hsa-miR-29b-3p	MFAP2	0.178522712044526	0.0856106432164969	-1.34080749520146	7.26311115364028e-12	miRNATAP	-0.208509376679349	0.0275588061191521		NA	NA	NA
hsa-miR-29b-3p	MIER3	0.178522712044526	0.0856106432164969	-0.059392642084636	0.191322147750781	MirTarget;miRNATAP	-0.135166064640276	5.70167451816099e-17		NA	NA	NA
hsa-miR-29b-3p	MKI67	0.178522712044526	0.0856106432164969	-1.50932313864686	3.69002217533919e-17	miRNAWalker2_validate	-0.741414840392834	1.38835022164411e-18		NA	NA	NA
hsa-miR-29b-3p	MLXIP	0.178522712044526	0.0856106432164969	-0.189985094190098	0.000370271794914548	MirTarget	-0.133556306871844	3.44065384078819e-10		NA	NA	NA
hsa-miR-29b-3p	MMD2	0.178522712044526	0.0856106432164969	0.721232908476843	9.61591822140039e-07	miRNATAP	-0.153234224512208	0.0277621928624441		NA	NA	NA
hsa-miR-29b-3p	MMP15	0.178522712044526	0.0856106432164969	-0.0976564976223475	0.232011250327681	miRNAWalker2_validate	-0.301244219809462	3.4260954205565e-18		NA	NA	NA
hsa-miR-29b-3p	MMP2	0.178522712044526	0.0856106432164969	-0.704014978384594	1.08365653245423e-12	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.279098360745868	5.04515764540177e-10	26155940;20657750;25866219;24130681;24130168;26063204	In this study we found that only miR-29b inhibited tumor cell migration and invasion by reducing MMP-2 activity via phospho-AKT/β-catenin signaling and stimulated a more epithelial-like morphology;Further a novel target with potential implications for invasion and metastasis matrix metallopeptidase-2 MMP-2 was identified and confirmed to be a miR-29b target in prostate cancer cells;miR 29b inhibits the progression of esophageal squamous cell carcinoma by targeting MMP 2; The impact of overexpression of miR-29b on putative target MMP-2 were subsequently confirmed via Western blot; Overexpression of miR-29b significantly decreased p<0.05 the protein level of MMP-2 which has previously been identified as a direct target of miR-29b; Thus our study demonstrated that overexpression of miR-29b inhibits tumor growth in part by targeting MMP-2;Since miR-29b plays a role in regulating the migration of cancer cells we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 MMP-2 thereby suppressing the migration of colon cancer cells; Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA; Western blotting and quantitative RT-PCR indicated that miR-29b down-regulated the expression of MMP2 at the protein and mRNA levels; Taken together our results demonstrate that miR-29b serves as a tumor metastasis suppressor which suppresses NSCLC cell metastasis by directly inhibiting MMP2 expression	cell migration;metastasis;progression;;;metastasis	glioblastoma;prostate cancer;esophageal cancer;colon cancer;gastric cancer;lung squamous cell cancer
hsa-miR-29b-3p	MSTN	0.178522712044526	0.0856106432164969	0.200420694909308	0.307973616550615	miRNATAP	-0.419690968823661	4.60885127935001e-06		NA	NA	NA
hsa-miR-29b-3p	MTMR3	0.178522712044526	0.0856106432164969	0.152092830912389	0.0028194932062445	mirMAP	-0.115666418637883	2.17921487130768e-13		NA	NA	NA
hsa-miR-29b-3p	MYBL2	0.178522712044526	0.0856106432164969	-1.85980674631409	6.35729672749517e-20	miRNATAP	-0.833656217323632	8.31419524680757e-18		NA	NA	NA
hsa-miR-29b-3p	MYCN	0.178522712044526	0.0856106432164969	0.0727164386918853	0.479635667277214	miRNAWalker2_validate;MirTarget;miRNATAP	-0.385583831147444	5.20950889774138e-17		NA	NA	NA
hsa-miR-29b-3p	MYO16	0.178522712044526	0.0856106432164969	0.395526990666966	0.00114657720263599	MirTarget	-0.221180932933477	8.79777645209012e-05		NA	NA	NA
hsa-miR-29b-3p	N4BP2	0.178522712044526	0.0856106432164969	-0.253693230593845	0.0226146277507554	miRNATAP	-0.360043939265729	2.06533672588455e-12		NA	NA	NA
hsa-miR-29b-3p	NAA40	0.178522712044526	0.0856106432164969	-0.0518088080403407	0.273899232983765	MirTarget;miRNATAP	-0.15885113051141	7.78687022245979e-20		NA	NA	NA
hsa-miR-29b-3p	NASP	0.178522712044526	0.0856106432164969	-0.233429960081303	0.000252342074373198	miRNAWalker2_validate;miRTarBase;MirTarget	-0.158633038485725	4.06432231104051e-11		NA	NA	NA
hsa-miR-29b-3p	NAV1	0.178522712044526	0.0856106432164969	0.157652541316568	0.0358743545108639	MirTarget;miRNATAP	-0.249300199006498	1.4668835586556e-18		NA	NA	NA
hsa-miR-29b-3p	NAV2	0.178522712044526	0.0856106432164969	0.0241477736119666	0.745332950197792	MirTarget;miRNATAP	-0.186002045076806	1.39358449093072e-10		NA	NA	NA
hsa-miR-29b-3p	NCKAP5L	0.178522712044526	0.0856106432164969	-0.0412523572128087	0.393392098927836	miRNATAP	-0.139853332940916	7.99167583788804e-17		NA	NA	NA
hsa-miR-29b-3p	NCOA3	0.178522712044526	0.0856106432164969	-0.0268931791865645	0.574089097748782	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.122650503965212	6.91712304946962e-13		NA	NA	NA
hsa-miR-29b-3p	NCOR2	0.178522712044526	0.0856106432164969	0.053981933966897	0.42765347805097	miRNATAP	-0.167627591040107	2.04770312850153e-13		NA	NA	NA
hsa-miR-29b-3p	NFIB	0.178522712044526	0.0856106432164969	0.151336169908435	0.0298860513853786	miRNATAP	-0.243816009021583	2.54139764475277e-20		NA	NA	NA
hsa-miR-29b-3p	NID1	0.178522712044526	0.0856106432164969	-0.426636719335625	1.45299433943869e-05	miRNAWalker2_validate;miRTarBase;MirTarget	-0.425960223537664	1.84495364336836e-23		NA	NA	NA
hsa-miR-29b-3p	NKIRAS2	0.178522712044526	0.0856106432164969	-0.30712257136225	1.54887314183599e-08	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.256299186017359	5.50596787497915e-38		NA	NA	NA
hsa-miR-29b-3p	NKTR	0.178522712044526	0.0856106432164969	0.0819071476786535	0.233532299223289	MirTarget;miRNATAP	-0.19031259894852	1.9446242588171e-12		NA	NA	NA
hsa-miR-29b-3p	NLGN3	0.178522712044526	0.0856106432164969	0.105955998628568	0.225953201785971	MirTarget;miRNATAP	-0.128290412856678	0.000427376562265356		NA	NA	NA
hsa-miR-29b-3p	NLRX1	0.178522712044526	0.0856106432164969	0.0508347391802193	0.285369846174543	miRNATAP	-0.101495479036754	8.39343305618133e-08		NA	NA	NA
hsa-miR-29b-3p	NOTCH2	0.178522712044526	0.0856106432164969	-0.0265373761476884	0.759991465967001	MirTarget	-0.100449994874329	0.00373643393819674		NA	NA	NA
hsa-miR-29b-3p	NPAS3	0.178522712044526	0.0856106432164969	0.125692939469159	0.0417128993506105	miRNATAP	-0.178189569879083	6.94217759024169e-15		NA	NA	NA
hsa-miR-29b-3p	NTN1	0.178522712044526	0.0856106432164969	-0.230577873621963	0.0100391058601805	mirMAP	-0.320692434160865	1.78890200830746e-17		NA	NA	NA
hsa-miR-29b-3p	NUP160	0.178522712044526	0.0856106432164969	-0.184917972681883	0.00076004095910411	MirTarget;miRNATAP	-0.238918989181151	6.00936407881339e-31		NA	NA	NA
hsa-miR-29b-3p	ONECUT2	0.178522712044526	0.0856106432164969	-0.0592720542393952	0.626992163670138	mirMAP;miRNATAP	-0.409276655182814	3.23563030972065e-13		NA	NA	NA
hsa-miR-29b-3p	OPHN1	0.178522712044526	0.0856106432164969	0.470732943812718	1.62843731556359e-06	mirMAP	-0.332533881645834	7.19131233067693e-16		NA	NA	NA
hsa-miR-29b-3p	OSBPL11	0.178522712044526	0.0856106432164969	0.439814383923316	1.98180004335249e-06	MirTarget	-0.104082124513742	0.00947084018823826		NA	NA	NA
hsa-miR-29b-3p	PAN2	0.178522712044526	0.0856106432164969	-0.0561220786803336	0.318556156624658	MirTarget;miRNATAP	-0.174333709086987	7.44747674710183e-15		NA	NA	NA
hsa-miR-29b-3p	PCDH17	0.178522712044526	0.0856106432164969	0.164985404584717	0.023700708785988	MirTarget;miRNATAP	-0.108531496536395	0.00024576019473937		NA	NA	NA
hsa-miR-29b-3p	PDGFRA	0.178522712044526	0.0856106432164969	0.214227835759105	0.123422750860141	MirTarget	-0.479354783825126	2.78031130409556e-15		NA	NA	NA
hsa-miR-29b-3p	PGM3	0.178522712044526	0.0856106432164969	-0.0158412390513352	0.772982309757557	MirTarget	-0.195624707183888	5.76707057310523e-19		NA	NA	NA
hsa-miR-29b-3p	PHC1	0.178522712044526	0.0856106432164969	0.0673017532974995	0.244454841610852	MirTarget	-0.245576268221423	1.73602635649316e-31		NA	NA	NA
hsa-miR-29b-3p	PHF21A	0.178522712044526	0.0856106432164969	0.0808475917900529	0.123057895195032	MirTarget	-0.159774952048679	1.60190368623445e-21		NA	NA	NA
hsa-miR-29b-3p	PIK3R1	0.178522712044526	0.0856106432164969	0.259275224308789	0.00106935451973317	MirTarget;miRNATAP	-0.145678229090259	1.47483484512088e-06		NA	NA	NA
hsa-miR-29b-3p	PIKFYVE	0.178522712044526	0.0856106432164969	0.101814168429243	0.0766802966197961	MirTarget	-0.100472226784358	5.30415297226277e-06		NA	NA	NA
hsa-miR-29b-3p	PITX1	0.178522712044526	0.0856106432164969	-1.04961796208943	1.80061166893988e-06	mirMAP	-0.416277842764416	6.64334733607251e-05		NA	NA	NA
hsa-miR-29b-3p	POFUT2	0.178522712044526	0.0856106432164969	-0.0888309271662386	0.0704201719803718	mirMAP	-0.143447060116239	1.9714268246707e-14		NA	NA	NA
hsa-miR-29b-3p	POU2F1	0.178522712044526	0.0856106432164969	0.0399519573658771	0.528984908427906	miRNATAP	-0.121186321645283	2.7596500492959e-05		NA	NA	NA
hsa-miR-29b-3p	PPIF	0.178522712044526	0.0856106432164969	0.144644009312131	0.0748430302544796	MirTarget	-0.144332163196349	1.37788565917436e-05		NA	NA	NA
hsa-miR-29b-3p	PPM1D	0.178522712044526	0.0856106432164969	-0.223880834234616	4.58568238565114e-06	MirTarget;miRNATAP	-0.175389086111835	4.34809545023955e-19		NA	NA	NA
hsa-miR-29b-3p	PRKX	0.178522712044526	0.0856106432164969	0.234656702391645	0.00431000884646549	mirMAP	-0.173413136803338	1.43367881926089e-06		NA	NA	NA
hsa-miR-29b-3p	PRRT4	0.178522712044526	0.0856106432164969	0.0318868209615641	0.7716194962204	miRNATAP	-0.259940710866156	3.80459895525203e-07		NA	NA	NA
hsa-miR-29b-3p	PTX3	0.178522712044526	0.0856106432164969	-0.949207819870183	5.94256337900885e-12	MirTarget	-0.182517698056509	0.00624977340297341		NA	NA	NA
hsa-miR-29b-3p	PXDN	0.178522712044526	0.0856106432164969	-0.268348436337947	0.0134086080323516	MirTarget;miRNATAP	-0.468971824196058	3.07210446952075e-23		NA	NA	NA
hsa-miR-29b-3p	RCC2	0.178522712044526	0.0856106432164969	-0.296909456658331	5.34511189766082e-06	MirTarget;miRNATAP	-0.151335813237716	6.54988020845206e-10		NA	NA	NA
hsa-miR-29b-3p	RCOR1	0.178522712044526	0.0856106432164969	-0.00675111501441616	0.888766577570543	miRNATAP	-0.162399214406736	7.4272394013989e-21		NA	NA	NA
hsa-miR-29b-3p	REV3L	0.178522712044526	0.0856106432164969	-0.121609999036417	0.0738205804839239	MirTarget;miRNATAP	-0.238466852099247	1.3267507556623e-17		NA	NA	NA
hsa-miR-29b-3p	RFX7	0.178522712044526	0.0856106432164969	0.0898721554790676	0.161769326298286	MirTarget	-0.265667719629217	6.91921120260074e-26		NA	NA	NA
hsa-miR-29b-3p	RNF138	0.178522712044526	0.0856106432164969	-0.100567558192888	0.0267106458191522	MirTarget;miRNATAP	-0.141359147082093	1.07611358822668e-16		NA	NA	NA
hsa-miR-29b-3p	RNF165	0.178522712044526	0.0856106432164969	0.330200178204771	0.00335054581609303	MirTarget;miRNATAP	-0.238823956706076	3.97210416040261e-06		NA	NA	NA
hsa-miR-29b-3p	RNF169	0.178522712044526	0.0856106432164969	-0.000327726986476762	0.99570798476294	miRNATAP	-0.147347316330489	1.63928956258151e-08		NA	NA	NA
hsa-miR-29b-3p	RNF39	0.178522712044526	0.0856106432164969	0.217428283250821	0.00534072600007186	MirTarget	-0.176502949643028	1.3307442917655e-06		NA	NA	NA
hsa-miR-29b-3p	ROBO1	0.178522712044526	0.0856106432164969	0.122056625212687	0.245847633195709	MirTarget	-0.308413728580206	2.83991240586782e-11		NA	NA	NA
hsa-miR-29b-3p	RPS4X	0.178522712044526	0.0856106432164969	0.0201143545358082	0.79095523516787	miRNAWalker2_validate	-0.152328128003257	1.37188165357549e-09		NA	NA	NA
hsa-miR-29b-3p	SBF2	0.178522712044526	0.0856106432164969	0.0654365826778029	0.322789274713217	miRNATAP	-0.165680795303915	1.54659252317203e-10		NA	NA	NA
hsa-miR-29b-3p	SCML2	0.178522712044526	0.0856106432164969	0.00620039542347128	0.94243655857149	MirTarget;miRNATAP	-0.348649628093172	4.50190248998272e-19		NA	NA	NA
hsa-miR-29b-3p	SEC11A	0.178522712044526	0.0856106432164969	-0.120284160254744	0.0308195087185353	MirTarget	-0.112754691405556	9.68036681038559e-09		NA	NA	NA
hsa-miR-29b-3p	SEMA5A	0.178522712044526	0.0856106432164969	-0.173308962323466	0.0987152373996812	mirMAP	-0.232850962719281	4.34369253274349e-07		NA	NA	NA
hsa-miR-29b-3p	SENP1	0.178522712044526	0.0856106432164969	-0.151732317550273	0.000949134465382843	miRNATAP	-0.190448684827967	7.978284084451e-26		NA	NA	NA
hsa-miR-29b-3p	SERPINH1	0.178522712044526	0.0856106432164969	-0.849993739099279	4.59473510522891e-17	miRNATAP	-0.161549768059797	0.000691653777931084		NA	NA	NA
hsa-miR-29b-3p	SETDB1	0.178522712044526	0.0856106432164969	-0.0869395117995078	0.0702945939156707	MirTarget;miRNATAP	-0.217067778867215	5.6851390424532e-43		NA	NA	NA
hsa-miR-29b-3p	SFPQ	0.178522712044526	0.0856106432164969	-0.0835641630565078	0.115628050536077	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.114210550713013	5.31461173413912e-16		NA	NA	NA
hsa-miR-29b-3p	SH3RF3	0.178522712044526	0.0856106432164969	-0.0715841319745367	0.227145830166532	MirTarget;miRNATAP	-0.100049134120068	2.45134003744856e-05		NA	NA	NA
hsa-miR-29b-3p	SHPRH	0.178522712044526	0.0856106432164969	0.114546874631669	0.18324076286944	MirTarget	-0.212666241829903	5.96464580941332e-08		NA	NA	NA
hsa-miR-29b-3p	SIRT1	0.178522712044526	0.0856106432164969	0.191530888683367	0.000540788088572047	MirTarget	-0.131888318815328	2.69808011613576e-09		NA	NA	NA
hsa-miR-29b-3p	SLC16A2	0.178522712044526	0.0856106432164969	0.0418345793620309	0.418208764861647	miRNATAP	-0.145422757174064	6.09397989240324e-15		NA	NA	NA
hsa-miR-29b-3p	SLC25A15	0.178522712044526	0.0856106432164969	-0.0836322932371205	0.109488987921478	MirTarget	-0.201617290206899	3.04053871570456e-20		NA	NA	NA
hsa-miR-320a	SLC2A3	-0.0921355996367019	0.243028758990046	-0.185554878787374	0.0598445176313112	miRanda	-0.188843552541488	0.00420631627962161		NA	NA	NA
hsa-miR-29b-3p	SLC4A7	0.178522712044526	0.0856106432164969	-0.356412791759793	1.40148461685098e-07	MirTarget;miRNATAP	-0.157976482083699	1.37964177984602e-07		NA	NA	NA
hsa-miR-29b-3p	SLC7A6	0.178522712044526	0.0856106432164969	-0.0667709161293359	0.101640103716086	MirTarget	-0.103357624061232	7.71959820764306e-16		NA	NA	NA
hsa-miR-29b-3p	SMARCC1	0.178522712044526	0.0856106432164969	-0.092789110723845	0.137124474243541	miRNAWalker2_validate;miRNATAP	-0.241681648505575	1.7989225252336e-27		NA	NA	NA
hsa-miR-29b-3p	SMPD3	0.178522712044526	0.0856106432164969	0.528583624465288	1.14299467933259e-07	MirTarget	-0.128414544056843	0.00593509557336138		NA	NA	NA
hsa-miR-29b-3p	SOX12	0.178522712044526	0.0856106432164969	-0.129091799823172	0.047221646929581	MirTarget;miRNATAP	-0.269753334359472	7.91813050335011e-27		NA	NA	NA
hsa-miR-29b-3p	SOX6	0.178522712044526	0.0856106432164969	0.128649486739933	0.179859567069835	mirMAP	-0.412238320180041	8.38173035528112e-26		NA	NA	NA
hsa-miR-29b-3p	SP1	0.178522712044526	0.0856106432164969	-0.106533496395966	0.0347129391168441	miRNAWalker2_validate;miRTarBase	-0.129990713086677	1.35066869744166e-14		NA	NA	NA
hsa-miR-29b-3p	SPARC	0.178522712044526	0.0856106432164969	0.352345598931374	0.00284630699754271	miRNATAP	-0.167632917775212	0.000479414253706488		NA	NA	NA
hsa-miR-29b-3p	SPEN	0.178522712044526	0.0856106432164969	0.0302290939541257	0.634085718930183	MirTarget;miRNATAP	-0.106637109710091	2.20415265491741e-06		NA	NA	NA
hsa-miR-29b-3p	SPNS1	0.178522712044526	0.0856106432164969	-0.0929278116318288	0.0577896151330001	miRNATAP	-0.167722445935555	5.89148960261792e-22		NA	NA	NA
hsa-miR-29b-3p	SPSB4	0.178522712044526	0.0856106432164969	-0.249426607836835	0.0112207830821016	miRNATAP	-0.433174047689626	1.0416440969081e-22		NA	NA	NA
hsa-miR-29b-3p	SSTR5	0.178522712044526	0.0856106432164969	0.691078123823692	4.59658583602678e-05	mirMAP	-0.467309638409315	4.39734509225352e-09		NA	NA	NA
hsa-miR-29b-3p	STAG2	0.178522712044526	0.0856106432164969	0.0218009698394539	0.69558723695437	MirTarget;miRNATAP	-0.170379383220219	3.32957900458646e-21		NA	NA	NA
hsa-miR-29b-3p	SYNCRIP	0.178522712044526	0.0856106432164969	-0.0928704077224882	0.0637674277640584	miRNATAP	-0.140499756795427	4.10783000296419e-24		NA	NA	NA
hsa-miR-29b-3p	TAF5	0.178522712044526	0.0856106432164969	-0.0291340039102841	0.517501379142506	miRNATAP	-0.131221276068218	2.37181478881716e-11		NA	NA	NA
hsa-miR-29b-3p	TANC1	0.178522712044526	0.0856106432164969	-0.28847742384092	9.16120269084615e-06	miRNATAP	-0.166346318962996	2.66731901452755e-10		NA	NA	NA
hsa-miR-29b-3p	TBX21	0.178522712044526	0.0856106432164969	-0.707068362487401	1.5941590498301e-08	miRNAWalker2_validate;miRTarBase	-0.120110208867549	0.0449808339431294		NA	NA	NA
hsa-miR-29b-3p	TCF3	0.178522712044526	0.0856106432164969	-0.169266059204923	0.0112915303563002	mirMAP	-0.339687118777122	1.17829885952942e-47		NA	NA	NA
hsa-miR-29b-3p	TCF4	0.178522712044526	0.0856106432164969	0.0262308656016526	0.696614338029438	miRNATAP	-0.205317624968147	8.69255905988575e-19		NA	NA	NA
hsa-miR-29b-3p	TDG	0.178522712044526	0.0856106432164969	-0.153514152590888	0.000336443365077273	miRNATAP	-0.124960803290586	7.39069116830625e-13		NA	NA	NA
hsa-miR-29b-3p	TEAD1	0.178522712044526	0.0856106432164969	0.00514554964397007	0.94008046165122	mirMAP	-0.217935664425243	2.17814160615658e-17		NA	NA	NA
hsa-miR-29b-3p	TET1	0.178522712044526	0.0856106432164969	0.32640694280032	0.000352680131894381	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.432939547558715	1.67202047297176e-26	25367851;25616722	Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; MiR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression;Erratum to: Negative feedback of miR 29 family TET1 involves in hepatocellular cancer; miR-29b was proved to inhibit metastasis through the targeting of TET1 indicating that downregulation of miR-29 may involve in HCC carcinogenesis and progression through potentiation of TET1 expression	metastasis;progression;tumorigenesis;metastasis;progression;tumorigenesis	liver cancer;liver cancer
hsa-miR-29b-3p	TET2	0.178522712044526	0.0856106432164969	0.116190829615161	0.0502346539924286	miRNATAP	-0.2278227325088	8.63856576558344e-23		NA	NA	NA
hsa-miR-29b-3p	TFDP2	0.178522712044526	0.0856106432164969	-0.133044187484978	0.0158352196266728	mirMAP	-0.158802591725687	2.25364273937557e-11		NA	NA	NA
hsa-miR-29b-3p	THAP2	0.178522712044526	0.0856106432164969	0.054975608332366	0.286223964200345	MirTarget	-0.116718054608338	5.34727334791376e-08		NA	NA	NA
hsa-miR-29b-3p	THSD4	0.178522712044526	0.0856106432164969	0.427524085422423	0.000215654756830008	miRNATAP	-0.126428891142746	0.0194089542548142		NA	NA	NA
hsa-miR-29b-3p	TMEM108	0.178522712044526	0.0856106432164969	0.105709750111664	0.175984761131231	mirMAP	-0.167341200828343	7.66289536323042e-07		NA	NA	NA
hsa-miR-29b-3p	TMEM169	0.178522712044526	0.0856106432164969	0.0560985412377222	0.493714994955467	MirTarget;miRNATAP	-0.197623930650677	8.07049476141733e-08		NA	NA	NA
hsa-miR-29b-3p	TNRC18	0.178522712044526	0.0856106432164969	-0.0721521106349821	0.210760132651975	miRNATAP	-0.195268676607493	6.01802555048828e-24		NA	NA	NA
hsa-miR-29b-3p	TNRC6B	0.178522712044526	0.0856106432164969	0.142640325533407	0.00666673288899363	miRNATAP	-0.114276240288493	1.20307881723623e-09		NA	NA	NA
hsa-miR-29b-3p	TRAF4	0.178522712044526	0.0856106432164969	-0.221757102835578	0.00709318578689758	miRNATAP	-0.234719881594967	1.47757511733738e-11		NA	NA	NA
hsa-miR-29b-3p	TRAFD1	0.178522712044526	0.0856106432164969	-0.11591334425106	0.0122076551024853	miRNATAP	-0.131301022856687	1.55441022260152e-19		NA	NA	NA
hsa-miR-29b-3p	TRIB2	0.178522712044526	0.0856106432164969	-0.266872034798271	0.00199622344818235	MirTarget;miRNATAP	-0.226616707490428	1.38862859926738e-09		NA	NA	NA
hsa-miR-29b-3p	TRIM67	0.178522712044526	0.0856106432164969	0.561251494130184	0.0206518750701024	mirMAP	-0.433512856655499	0.00015578659175952		NA	NA	NA
hsa-miR-29b-3p	TRIM9	0.178522712044526	0.0856106432164969	0.0187324302090888	0.799389498159473	miRNATAP	-0.240874732024898	3.99070654712675e-20		NA	NA	NA
hsa-miR-29b-3p	TSPAN11	0.178522712044526	0.0856106432164969	0.068822150891231	0.467785534655861	mirMAP	-0.381902560630517	3.5198276113592e-21		NA	NA	NA
hsa-miR-29b-3p	TTC14	0.178522712044526	0.0856106432164969	0.116815613701868	0.069110352029406	miRNATAP	-0.15317022575701	1.17132276946932e-08		NA	NA	NA
hsa-miR-29b-3p	UBN2	0.178522712044526	0.0856106432164969	0.0682064299334053	0.196196220075751	miRNATAP	-0.157583679431843	1.07897609364999e-14		NA	NA	NA
hsa-miR-29b-3p	UBTD2	0.178522712044526	0.0856106432164969	-0.131971365439875	0.00541994095397046	MirTarget;miRNATAP	-0.173008576712509	1.41320335270071e-24		NA	NA	NA
hsa-miR-29b-3p	UNK	0.178522712044526	0.0856106432164969	-0.0839188854501778	0.096555364208008	miRNATAP	-0.209022917255854	2.26034345787772e-33		NA	NA	NA
hsa-miR-29b-3p	USP13	0.178522712044526	0.0856106432164969	-0.0462667782738864	0.3384569088311	mirMAP	-0.142603975470529	7.60568446461645e-15		NA	NA	NA
hsa-miR-29b-3p	USP37	0.178522712044526	0.0856106432164969	-0.0109754080820004	0.805426261514372	MirTarget;miRNATAP	-0.111360059146468	9.54936357117551e-11		NA	NA	NA
hsa-miR-29b-3p	USP42	0.178522712044526	0.0856106432164969	-0.145348468702277	0.000517697174268754	miRNATAP	-0.14818578406528	6.40432105123036e-22		NA	NA	NA
hsa-miR-29b-3p	VASH1	0.178522712044526	0.0856106432164969	-0.176126671649525	0.00358879769700576	MirTarget	-0.153559786421876	9.74079236775223e-12		NA	NA	NA
hsa-miR-29b-3p	VASH2	0.178522712044526	0.0856106432164969	-0.281394374703266	0.0109642635707869	MirTarget;miRNATAP	-0.28867488535432	2.79612727761296e-08		NA	NA	NA
hsa-miR-29b-3p	VEGFA	0.178522712044526	0.0856106432164969	-0.545202702414803	3.65580722751304e-08	miRNAWalker2_validate;miRTarBase;MirTarget	-0.174785884873336	0.000121514677714241	26155940;22815235	Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b	;	glioblastoma;prostate cancer
hsa-miR-29b-3p	VPS25	0.178522712044526	0.0856106432164969	-0.106004461849301	0.00981608476195349	miRNATAP	-0.116728542926869	2.06497714330085e-16		NA	NA	NA
hsa-miR-29b-3p	XKR6	0.178522712044526	0.0856106432164969	-0.0857490757507903	0.183764821872107	MirTarget;miRNATAP	-0.256001343703017	3.7305873619594e-18		NA	NA	NA
hsa-miR-29b-3p	XKR7	0.178522712044526	0.0856106432164969	0.90697659571196	7.88736361528718e-05	MirTarget	-0.249338024767789	0.0227915388582099		NA	NA	NA
hsa-miR-29b-3p	XPO5	0.178522712044526	0.0856106432164969	-0.193019681488984	0.00016247873622734	miRNATAP	-0.217680005732945	7.1919259354543e-37		NA	NA	NA
hsa-miR-29b-3p	XRN1	0.178522712044526	0.0856106432164969	0.0290879496449721	0.557832574055449	MirTarget	-0.137666263090242	6.35866449851193e-13		NA	NA	NA
hsa-miR-29b-3p	ZBTB10	0.178522712044526	0.0856106432164969	-0.0333167190350974	0.611231865149489	MirTarget;miRNATAP	-0.237218268907502	2.78405474781819e-18		NA	NA	NA
hsa-miR-29b-3p	ZBTB5	0.178522712044526	0.0856106432164969	0.0234997839201423	0.639861245664838	MirTarget;miRNATAP	-0.216159421494233	1.46430323659127e-30		NA	NA	NA
hsa-miR-29b-3p	ZC4H2	0.178522712044526	0.0856106432164969	0.174598696766907	0.0172234502726095	miRNATAP	-0.212640833985558	3.26579597359826e-11		NA	NA	NA
hsa-miR-29b-3p	ZFX	0.178522712044526	0.0856106432164969	0.0621603903561203	0.259433298545986	miRNATAP	-0.11037147206792	2.11206481911867e-06		NA	NA	NA
hsa-miR-29b-3p	ZMIZ1	0.178522712044526	0.0856106432164969	0.202575080400734	0.00446802569057904	miRNATAP	-0.19696042482923	7.7380318797954e-15		NA	NA	NA
hsa-miR-29b-3p	ZNF282	0.178522712044526	0.0856106432164969	-0.061929025461934	0.175062730003667	MirTarget;miRNATAP	-0.164778936500278	2.37021732941508e-26		NA	NA	NA
hsa-miR-29b-3p	ZNF469	0.178522712044526	0.0856106432164969	-0.0979199600891398	0.377332966886498	miRNATAP	-0.140062297066248	0.00625988384486419		NA	NA	NA
hsa-miR-29b-3p	ZNF512B	0.178522712044526	0.0856106432164969	-0.00780952436671534	0.877166807659642	MirTarget;miRNATAP	-0.130939324609711	4.24894698639576e-14		NA	NA	NA
hsa-miR-29b-3p	ZNF532	0.178522712044526	0.0856106432164969	-0.0261479925985491	0.637446913772171	miRNATAP	-0.116824655048354	6.33249522468265e-11		NA	NA	NA
hsa-miR-29b-3p	ZNF609	0.178522712044526	0.0856106432164969	0.206272333205747	0.000711049680314407	miRNATAP	-0.164664543579874	4.30772273390276e-14		NA	NA	NA
hsa-miR-29b-3p	ZNF704	0.178522712044526	0.0856106432164969	-0.0745646034130578	0.402705332314327	MirTarget;miRNATAP	-0.23609774885771	5.41480291287926e-09		NA	NA	NA