miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p BCL2 0.618599506841644 2.76973453058748e-05 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.227211670110314 0.0179425982768944 hsa-miR-101-3p CAPN2 0.522819989585461 0.00375627731618038 -0.422341253524924 0.0913287396375096 miRNAWalker2_validate;MirTarget -0.50384520654326 1.83370655936121e-14 hsa-miR-103a-3p BCL2 1.44083190496858 1.53799939616416e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.316592082591341 5.34263132858783e-06 hsa-miR-103a-3p PRKAR2A 1.44083190496858 1.53799939616416e-13 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.350849310244118 1.94773064927018e-06 hsa-miR-106a-5p FAS 2.48882002962836 1.99757727374521e-12 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate;miRTarBase -0.286433262215431 2.93487884151059e-11 hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 hsa-miR-10b-5p PPP3CB -0.155951595811628 0.555006386998027 -1.03671584843429 6.12489584217064e-15 miRNAWalker2_validate -0.0869895000990222 0.000541944702005189 hsa-miR-1226-3p IRAK1 1.38118928579963 0.000205503474787488 0.6373544526515 0.00032590064915133 miRNAWalker2_validate -0.106240098169623 4.99256151870902e-05 hsa-miR-125b-5p AKT1 -1.16462950151259 0.000288900271798384 0.128947014292221 0.203881780391473 miRNAWalker2_validate;miRTarBase -0.0754219304397887 4.30762607612109e-07 hsa-miR-125b-5p XIAP -1.16462950151259 0.000288900271798384 0.0185824727941606 0.900456705596673 miRNAWalker2_validate -0.134609008147354 6.17145452585339e-10 hsa-miR-1296-5p PRKAR1A 1.20556568733873 8.93601534401924e-06 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.0828840059385087 3.06637773247924e-05 hsa-miR-133a-3p PIK3R2 -3.38501431117712 1.32336729742128e-13 0.516358399200751 7.40068114798748e-05 miRNAWalker2_validate -0.0531718506280371 6.66834984264845e-05 hsa-miR-136-5p BCL2 2.09637138292451 1.50140005592201e-10 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.0848616871691006 0.0423848321932993 hsa-miR-145-5p DFFA -1.55259331973517 9.97889123247165e-07 0.401133064314179 0.000349148153504863 miRNAWalker2_validate;miRTarBase -0.0613743876259081 0.000270529331870507 hsa-miR-148b-3p PIK3CA 1.97815018171325 6.07715327281595e-26 -0.151828236462886 0.321284398928338 miRNAWalker2_validate -0.0970272057171793 0.00935664640842872 23233531 miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5 ROCK1 PIK3CA NRAS and CSF1 progression; breast cancer hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 hsa-miR-15a-5p BCL2 2.34669284378787 1.69544424500258e-23 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.391979588821952 1.08722628903108e-12 22335947;23867991;18931683;18931683;25623762;25623762;25623762 The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05;miR-15a and miR-16-1 are important tumor suppressors through modulating B cell lymphoma 2 Bcl-2 Cyclin D1 D2 and others;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;In cancer cells of advanced prostate tumors the miR-15a and miR-16 level is significantly decreased whereas the expression of BCL2 CCND1 and WNT3A is inversely upregulated;miR-15a and miR-16 modulate drug resistance by targeting bcl-2 in human colon cancer cells;To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The Western blot assay showed that the relative expressions of bcl-2 protein in the blank control group negative control group miR-15a mimic group and miR-16 mimic group were 1.00 0.97 ± 0.02 0.51 ± 0.06 and 0.65 ± 0.03 respectively and the expression of bcl-2 protein was decreased significantly P < 0.05 however the expressions of P-gp protein showed no significant difference ;;;staging;;drug resistance;;drug resistance;; breast cancer;lung cancer;prostate cancer;prostate cancer;colorectal cancer;colorectal cancer;colorectal cancer hsa-miR-15a-5p CHUK 2.34669284378787 1.69544424500258e-23 -0.123960303858583 0.302722046952969 miRNAWalker2_validate;miRTarBase;MirTarget -0.0500289622248936 0.0328799661580439 hsa-miR-15a-5p NFKB1 2.34669284378787 1.69544424500258e-23 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.0801546174320277 0.0108747972008633 hsa-miR-15b-5p BCL2 1.57112623124278 9.14247846750597e-13 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.256427911729671 3.30685638311642e-05 18449891;18449891;18449891 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells;The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein;Enforced mir-15b or miR-16 expression reduced Bcl-2 protein level and the luciferase activity of a BCL2 3' untranslated region-based reporter construct in SGC7901/VCR cells suggesting that BCL2 is a direct target of miR-15b and miR-16 drug resistance;;; stomach cancer;stomach cancer;stomach cancer hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 hsa-miR-16-5p BCL2 1.75824877145857 1.68592440033108e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.288487498854428 4.63144203616397e-06 hsa-miR-16-5p IRAK3 1.75824877145857 1.68592440033108e-16 -1.61324599744624 9.44362061411831e-07 miRNAWalker2_validate -0.294716229106297 5.37676785444093e-05 hsa-miR-16-5p PRKAR1A 1.75824877145857 1.68592440033108e-16 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.0635766416738103 0.0105940278364239 hsa-miR-16-5p PRKAR2A 1.75824877145857 1.68592440033108e-16 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.207299552214686 0.0020597428531192 hsa-miR-17-5p BCL2 3.2710598467455 9.93128340539455e-27 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.293095808916295 2.47054725414332e-12 25435430;25435430;25435430 MiR-16 targets Bcl-2 in paclitaxel-resistant lung cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis;Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively;miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 ;; lung cancer;lung cancer;lung cancer hsa-miR-17-5p PIK3CA 3.2710598467455 9.93128340539455e-27 -0.151828236462886 0.321284398928338 miRNAWalker2_validate -0.0509845431991425 0.0247256477578683 hsa-miR-181a-5p ATM 2.29556023480783 1.8138457900616e-21 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.126923788457429 2.84207726303723e-05 24531888 MicroRNA-181a functions as an oncomir in gastric cancer by targeting the tumour suppressor gene ATM stomach cancer hsa-miR-181a-5p BCL2 2.29556023480783 1.8138457900616e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.302999442697681 2.70012636306699e-08 hsa-miR-181b-5p BCL2 2.49307679431293 3.92829250217627e-20 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.305267910529038 2.57343031129337e-10 hsa-miR-181c-5p BCL2 1.58587920618301 1.57506918816933e-10 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.112460550118007 0.0424640002427638 hsa-miR-181d-5p BCL2 1.52204912185579 9.2693319057748e-08 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.138340152158444 0.00425126630916248 hsa-miR-182-5p BCL2 3.53923166221814 5.07781258121574e-21 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.179869914139863 2.52267854475577e-07 23936432 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 prostate cancer hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 hsa-miR-18a-5p ATM 3.78535678765353 3.72446596213886e-26 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.132647027735553 2.53006799595493e-10 hsa-miR-192-5p BCL2 2.69002528723195 1.22990188194432e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.208867066110207 3.33628652880772e-07 25566965 Moreover overexpression of miR-192 significantly induced apoptotic death in bladder cancer cells increased the levels of p21 p27 and Bax and decreased the levels of cyclin D1 Bcl-2 and Mcl-1 bladder cancer hsa-miR-192-5p ENDOD1 2.69002528723195 1.22990188194432e-16 -0.331902287589133 0.146465367778401 miRNAWalker2_validate -0.157492739481784 1.21322938151644e-06 hsa-miR-192-5p IL1R1 2.69002528723195 1.22990188194432e-16 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.18623904564978 4.77161512216095e-06 hsa-miR-192-5p IL1RAP 2.69002528723195 1.22990188194432e-16 0.687376288697117 0.0561773808581464 miRNAWalker2_validate -0.203023264982205 7.92657993381149e-05 hsa-miR-192-5p PRKAR1A 2.69002528723195 1.22990188194432e-16 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.0727399521419155 6.08880831882451e-06 hsa-miR-193b-3p CASP9 2.25711804611899 4.1940744806631e-14 -0.446359927280876 0.00400976702291555 miRNAWalker2_validate -0.0905760962799774 0.00019445516044014 hsa-miR-195-5p CHUK -1.44753678070504 8.70594292149271e-09 -0.123960303858583 0.302722046952969 miRNAWalker2_validate;MirTarget -0.0517847125621791 0.0226582563449759 hsa-miR-197-3p IL1R1 1.75733174019505 8.88576793100499e-13 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.245286619557537 6.97172291808552e-06 hsa-miR-197-3p PRKAR2A 1.75733174019505 8.88576793100499e-13 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.19132087635181 0.00112031547705946 hsa-miR-199a-5p IKBKB 0.592984035153911 0.0674836634175293 -0.00227190214342876 0.988714147115007 miRNAWalker2_validate;miRTarBase;miRanda;miRNATAP -0.0902751790213246 0.000147075149625618 hsa-miR-19b-3p ATM 2.49529833021187 1.57028265846699e-23 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.169669050219426 4.03808006538527e-09 hsa-miR-19b-3p PRKACB 2.49529833021187 1.57028265846699e-23 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.267352556269149 9.00420806048956e-11 hsa-miR-200b-3p BCL2 3.78235093249346 3.18343003239465e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;TargetScan;mirMAP -0.147905318391455 3.02424877197984e-08 hsa-miR-200c-3p BCL2 3.50132673580082 2.42716349086937e-15 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.190113918290914 1.87463163361428e-10 hsa-miR-20a-5p BCL2 3.15577933619191 4.19753346442454e-25 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.265706884379661 3.5423039457333e-10 hsa-miR-21-5p BCL2 2.73773305747971 1.38864982139576e-43 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.366618885310627 5.78881699391161e-09 hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 hsa-miR-214-3p TP53 -0.176344800034733 0.642485503428886 0.17313275059387 0.48779406985331 miRNAWalker2_validate;miRTarBase -0.0879929457575404 0.00576688203655961 22241525;22927443 Six differentially expressed miRNAs affected the TP53 pathway miR-122 miR-214 miR-372 miR-15b let-7e miR-17 P < 0.001;Enforcing expression of miR-214 increases whereas knockdown of miR-214 decreases OCSC population and self-renewal as well as the Nanog level preferentially in wild-type p53 cell lines ; colorectal cancer;ovarian cancer hsa-miR-215-5p BCL2 2.30755467422978 2.38476032118039e-06 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate -0.0826069551217565 0.00440672930203777 hsa-miR-215-5p IL1R1 2.30755467422978 2.38476032118039e-06 -0.754392858754991 0.00819157634786962 miRNAWalker2_validate -0.0751298193576192 0.00907325730526252 hsa-miR-215-5p IL1RAP 2.30755467422978 2.38476032118039e-06 0.687376288697117 0.0561773808581464 miRNAWalker2_validate -0.140484900749653 9.91578317658242e-05 hsa-miR-221-3p TP53 0.451556679024397 0.0909808299917811 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.115825211031354 0.0105671893909646 20880178;20880178;20880178;20880178;25431954;25431954;24324033;24324033;24324033;24324033 Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression;The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed;The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression;The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma;We explored the regulation of p53 by Notch3 signalling in three HCC cell lines HepG2 SNU398 and Hep3B.We found that Notch3 regulates p53 at post-transcriptional level controlling both Cyclin G1 expression and the feed-forward circuit involving p53 miR-221 and MDM2;In this study MDM2 E3 ubiquitin-protein ligase homolog a known p53 TP53 modulator is identified as a direct target of miR-221 and a feed-forward loop is described that sustains miR-221 aberrant expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression;Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines;These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation ;worse survival;;;worse prognosis;invasion;;;;;;progression;drug resistance;; colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;liver cancer;liver cancer;liver cancer;liver cancer;liver cancer;liver cancer hsa-miR-222-3p TP53 0.851783756239071 0.00266783568486918 0.17313275059387 0.48779406985331 miRNAWalker2_validate -0.116904656132339 0.00589565055970469 hsa-miR-23b-3p CHUK -0.251132426825047 0.150200321210792 -0.123960303858583 0.302722046952969 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.0766789350678081 0.0228889504061852 hsa-miR-24-2-5p BCL2 2.07171035460647 3.15853539996136e-16 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.329656547931865 2.75296639271459e-10 hsa-miR-25-3p PRKAR1A 1.36472605225697 4.83790725935681e-11 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate -0.130633923717046 3.57662021897474e-07 hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 hsa-miR-29b-3p BCL2 1.65828197923813 1.02676780888141e-09 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.296891319533915 2.28427123681482e-09 hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 hsa-miR-328-3p IRAK1 0.596804159297544 0.013858523511843 0.6373544526515 0.00032590064915133 miRNAWalker2_validate -0.0847980967833339 0.0175213264803641 hsa-miR-335-5p NFKBIA 1.77247705492746 2.22457658872091e-06 -0.720709911772914 0.00030878082790516 miRNAWalker2_validate -0.0642142341974141 0.012261469137936 hsa-miR-335-5p PIK3CA 1.77247705492746 2.22457658872091e-06 -0.151828236462886 0.321284398928338 miRNAWalker2_validate -0.0513085330553527 0.00840603787931949 hsa-miR-340-5p TNFRSF10B 0.30282999308409 0.157744789519131 0.0854160195132305 0.697363353003698 miRNAWalker2_validate -0.130618058364656 0.00887614707841885 hsa-miR-34a-5p BCL2 1.9016323452565 1.43092834643601e-14 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.313298897109154 6.78995714898249e-09 19714243;19714243;19714243;18803879;18803879;18803879;18803879;18803879;22623155;22623155;20687223;20687223;20687223;20687223;20687223;25053345;20433755;20433755;24565525;23155233;21909380;21399894;21399894;23862748;23862748;23862748;22438124;24444609 Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells;Restoration of miR-34 expression in the pancreatic cancer cells by either transfection of miR-34 mimics or infection with lentiviral miR-34-MIF downregulated Bcl-2 and Notch1/2 miR-34 restoration significantly inhibited clonogenic cell growth and invasion induced apoptosis and G1 and G2/M arrest in cell cycle and sensitized the cells to chemotherapy and radiation;Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells;Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter;Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2;Restoration of miR-34 chemosensitized Kato III cells with a high level of Bcl-2 but not MKN-45 cells with a low level of Bcl-2 miR-34 impaired cell growth accumulated the cells in G1 phase increased caspase-3 activation and more significantly inhibited tumorsphere formation and growth;The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1;Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;MiR-34a expression was reduced in PC3PR cells compared with PC3 cells while the expression levels of HuR and Bcl2 as well as SIRT1 were elevated in PC3PR cells;Introduction of miR-34a precursor into PC3PR cells resulted in decreases in HuR Bcl2 and SIRT1 expression and inhibition of the SIRT1 3'-UTR activity;These results suggest that miR-34a not only directly but also indirectly via regulating HuR expression acts on the 3'-UTR of SIRT1 and Bcl2 mRNAs thereby controlling their expression;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression;MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein;Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Treatment of pancreatic CSCs with the chromatin-modulating agents resulted in the inhibition of Bcl-2 CDK6 and SIRT1 which are the putative targets of miR-34a;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Modulation of miR-34a expression was correlated with BCL-2 and cyclin D1 protein expression changes and a direct interaction of miR-34a with BCL-2 was shown by luciferase assay;HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression;Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression;Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression;Furthermore cellular mechanism studies revealed that induction of miR-34a decreased the expression of Notch-1 and its downstream targets including Hes-1 Cyclin D1 Survivin and Bcl-2;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells worse survival;;invasion;;;worse survival;;;;;differentiation;;;;;;;drug resistance;;drug resistance;;drug resistance;;;;drug resistance;;;;;;;;;;worse survival; pancreatic cancer;pancreatic cancer;pancreatic cancer;stomach cancer;stomach cancer;stomach cancer;stomach cancer;stomach cancer;breast cancer;breast cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer;colorectal cancer;colorectal cancer;breast cancer;glioblastoma;pancreatic cancer;breast cancer;breast cancer;liver cancer;liver cancer;liver cancer;lung cancer;lung cancer hsa-miR-34a-5p BIRC3 1.9016323452565 1.43092834643601e-14 -1.14878434773067 0.00715931622274468 miRNAWalker2_validate -0.217054924716933 0.00780122048146313 hsa-miR-34a-5p PPP3R1 1.9016323452565 1.43092834643601e-14 -0.0284423401171923 0.760566460331176 miRNAWalker2_validate -0.0739854877233908 2.26982964925871e-05 hsa-miR-365a-3p BCL2 -0.0388985816963467 0.859114494267351 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase -0.26287248585935 3.91090481330584e-05 hsa-miR-421 ATM 1.17791565395543 6.78526676976629e-06 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda -0.0594136812739692 0.0431124517070599 hsa-miR-429 BCL2 4.48815175680773 2.44117492218206e-17 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;PITA;mirMAP -0.154017674076185 5.15216313360141e-10 hsa-miR-590-3p PRKAR2B 2.59289455139753 1.03200520972022e-21 -2.6424142214808 7.30155345842383e-13 miRNAWalker2_validate;miRanda -0.269901854229474 4.28450511206591e-05 hsa-miR-7-5p BCL2 2.28980165299999 1.5131097560452e-07 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;miRTarBase;mirMAP -0.178441327891617 1.03482718248784e-07 hsa-miR-7-5p CASP9 2.28980165299999 1.5131097560452e-07 -0.446359927280876 0.00400976702291555 miRNAWalker2_validate -0.0673187144793968 0.000217848216304623 hsa-miR-769-3p PRKAR2A 2.19896922202687 5.69250370895053e-12 -0.958058230501873 0.00166358416501506 miRNAWalker2_validate -0.102240179808546 0.0286231702957129 hsa-miR-92a-3p ATM 2.06460102658973 1.44784291084757e-19 -0.694304374354523 1.11905560067279e-05 miRNAWalker2_validate -0.174566583478402 5.02119051710453e-08 hsa-miR-92a-3p NFKB1 2.06460102658973 1.44784291084757e-19 -0.64818153460532 4.948433163113e-05 miRNAWalker2_validate -0.146602812476967 6.42472618908431e-06 hsa-miR-93-5p PRKACB 3.03961860136032 1.11672209617395e-24 -1.11910356116881 7.24897707751757e-07 miRNAWalker2_validate -0.194608106414379 2.15593790853491e-08 hsa-miR-96-5p BCL2 4.89433085814374 1.92000659886961e-31 -2.02088083891464 5.5300725103229e-13 miRNAWalker2_validate;TargetScan -0.202123113149013 6.78873155803595e-11 hsa-miR-96-5p PRKAR1A 4.89433085814374 1.92000659886961e-31 -0.494707246064478 1.09832496534671e-05 miRNAWalker2_validate;TargetScan;miRNATAP -0.0646429768713072 1.26970479323285e-07 hsa-miR-98-5p BIRC3 1.11154309866014 1.24143909012085e-08 -1.14878434773067 0.00715931622274468 miRNAWalker2_validate -0.732739588263987 1.05214961960018e-12 hsa-miR-98-5p FAS 1.11154309866014 1.24143909012085e-08 -0.893121037137088 0.00675655818216232 miRNAWalker2_validate -0.770550954607501 1.78193866759893e-23 hsa-miR-98-5p TNFSF10 1.11154309866014 1.24143909012085e-08 0.62151336306871 0.110711377947693 miRNAWalker2_validate -0.619752540788512 4.22417181054043e-11 hsa-miR-203a-3p TNF 3.12352008343999 9.49391438647189e-07 0.168287325738871 0.711715304997615 miRTarBase -0.111842196318691 0.000983994485349752 hsa-let-7a-3p PRKACB 1.42015538786275 7.03375209382654e-13 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.21962130459547 5.79651670137419e-05 hsa-let-7a-5p NGF 0.618599506841644 2.76973453058748e-05 -2.40747957908931 8.29529053936123e-07 MirTarget;TargetScan -0.725600120025055 8.99703032904097e-06 hsa-let-7b-3p PRKACB 0.868207752019623 1.30460056774366e-05 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP;miRNATAP -0.185130585565506 0.000844018426388941 hsa-let-7b-5p NGF 0.604314269683977 0.00140009936153214 -2.40747957908931 8.29529053936123e-07 MirTarget -0.445902124296935 0.000457128474125706 hsa-let-7d-3p PRKACB 0.837345596411224 1.39469480391458e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.193122206370836 0.000761987397647901 hsa-let-7d-5p NGF 1.33236798905207 1.1741085658466e-13 -2.40747957908931 8.29529053936123e-07 MirTarget -0.678554815907685 1.63174808684775e-07 hsa-let-7e-5p NGF 0.860104282510173 6.04758298373779e-05 -2.40747957908931 8.29529053936123e-07 MirTarget -0.426192872238101 0.000127971345995895 hsa-let-7f-1-3p PRKACB 1.55054488387679 7.31326775537952e-11 -1.11910356116881 7.24897707751757e-07 MirTarget;mirMAP -0.13342047017702 0.00451064067873152 hsa-let-7f-5p NGF 0.495648727272215 0.00355972741198794 -2.40747957908931 8.29529053936123e-07 MirTarget -0.599266844830758 2.3727191387735e-05 hsa-let-7g-5p NGF 1.20061455355116 1.50237505511483e-12 -2.40747957908931 8.29529053936123e-07 MirTarget -1.06245785714021 3.64026543085871e-15 hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 hsa-miR-106a-5p PIK3R1 2.48882002962836 1.99757727374521e-12 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.067882190368009 0.0381305246864511 hsa-miR-106a-5p IL1RAP 2.48882002962836 1.99757727374521e-12 0.687376288697117 0.0561773808581464 MirTarget -0.184285524641675 0.000113235346123953 hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 hsa-miR-106b-5p IL1RAP 2.46782146831112 1.36171495805632e-23 0.687376288697117 0.0561773808581464 MirTarget -0.308359753412902 3.66029994017838e-06 hsa-miR-106b-5p MAP3K14 2.46782146831112 1.36171495805632e-23 -0.929542138683687 1.31735308419243e-05 MirTarget -0.19000303078406 1.7530926860456e-06 hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 hsa-miR-129-5p ENDOD1 -0.524170159980738 0.222582956006346 -0.331902287589133 0.146465367778401 MirTarget;miRanda -0.101557070119569 9.90829354086753e-05 hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 hsa-miR-130b-3p IL1RAP 3.5350292994509 1.73934183852569e-27 0.687376288697117 0.0561773808581464 MirTarget -0.147309793399794 0.00330158193001679 hsa-miR-130b-3p ENDOD1 3.5350292994509 1.73934183852569e-27 -0.331902287589133 0.146465367778401 MirTarget -0.135527686049539 1.78733250260079e-05 hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 hsa-miR-141-3p PRKACB 5.02396127982626 2.19224509139725e-24 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 hsa-miR-143-3p CASP8 -2.5789192793377 1.55518999614836e-14 0.614672266065446 0.00102927275063291 MirTarget -0.0916491418973378 0.000456611797712721 hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 hsa-miR-1468-5p CAPN2 0.0469536064343461 0.881810795145912 -0.422341253524924 0.0913287396375096 MirTarget -0.232939493923959 7.04451041151474e-10 hsa-miR-148a-3p CHUK 1.26728238710376 2.52325607402829e-06 -0.123960303858583 0.302722046952969 MirTarget -0.0701344163836406 0.000974309950716782 hsa-miR-150-5p PIK3R1 -0.105827294491332 0.799351458244375 -1.16357283690918 1.63774086027679e-06 MirTarget -0.0728800512730481 0.0107125938650315 hsa-miR-155-5p XIAP 1.20164021433135 0.00086170622431261 0.0185824727941606 0.900456705596673 MirTarget -0.0764263500614685 0.000100628517502386 hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 hsa-miR-17-3p MAP3K14 2.2704817679209 1.1667437320211e-22 -0.929542138683687 1.31735308419243e-05 MirTarget -0.103035074073889 0.0162160477134261 hsa-miR-17-3p PPP3CA 2.2704817679209 1.1667437320211e-22 -0.281979431665802 0.0843014975757299 MirTarget -0.131133816129638 4.79999765543855e-05 hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 hsa-miR-17-5p MAP3K14 3.2710598467455 9.93128340539455e-27 -0.929542138683687 1.31735308419243e-05 MirTarget -0.10840260212945 0.000682220817217628 hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 hsa-miR-181a-5p ENDOD1 2.29556023480783 1.8138457900616e-21 -0.331902287589133 0.146465367778401 MirTarget -0.0971248096504928 0.026632641597437 hsa-miR-181b-5p ATM 2.49307679431293 3.92829250217627e-20 -0.694304374354523 1.11905560067279e-05 MirTarget -0.106546210489637 8.13310251996423e-05 hsa-miR-181b-5p CSF2RB 2.49307679431293 3.92829250217627e-20 -0.739086291347396 0.0696045958228138 MirTarget -0.199878586632952 0.0040462000934792 hsa-miR-181b-5p PIK3R3 2.49307679431293 3.92829250217627e-20 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.0888610194282689 0.0225315211910636 hsa-miR-181b-5p ENDOD1 2.49307679431293 3.92829250217627e-20 -0.331902287589133 0.146465367778401 MirTarget -0.0866691622342756 0.0263459095458543 hsa-miR-181c-5p ATM 1.58587920618301 1.57506918816933e-10 -0.694304374354523 1.11905560067279e-05 MirTarget -0.0964110139012526 0.00156794160688583 hsa-miR-181c-5p PPP3R1 1.58587920618301 1.57506918816933e-10 -0.0284423401171923 0.760566460331176 MirTarget;miRNATAP -0.0769473663852459 1.2130935030742e-05 hsa-miR-181c-5p CSF2RB 1.58587920618301 1.57506918816933e-10 -0.739086291347396 0.0696045958228138 MirTarget -0.192897492889798 0.0137082096418576 hsa-miR-181c-5p ENDOD1 1.58587920618301 1.57506918816933e-10 -0.331902287589133 0.146465367778401 MirTarget -0.181825067072814 2.96443076151955e-05 hsa-miR-181d-5p ATM 1.52204912185579 9.2693319057748e-08 -0.694304374354523 1.11905560067279e-05 MirTarget -0.0998255068171203 0.000176847482330073 hsa-miR-181d-5p CSF2RB 1.52204912185579 9.2693319057748e-08 -0.739086291347396 0.0696045958228138 MirTarget -0.305318018697499 6.94331838017145e-06 hsa-miR-181d-5p ENDOD1 1.52204912185579 9.2693319057748e-08 -0.331902287589133 0.146465367778401 MirTarget -0.151516261359878 7.10308197865111e-05 hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 hsa-miR-182-5p PRKACB 3.53923166221814 5.07781258121574e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.141282769334308 3.27226662914892e-07 hsa-miR-183-5p PRKACB 4.19757025992371 4.79612296318304e-26 -1.11910356116881 7.24897707751757e-07 MirTarget -0.132170429294976 3.08274590025093e-07 hsa-miR-185-3p MAP3K14 2.3922478518806 1.3373426768452e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.129581834416974 6.081635091056e-05 hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 hsa-miR-190a-5p IL1RAP 0.762748400660219 0.0035950590410453 0.687376288697117 0.0561773808581464 MirTarget -0.193022328361973 0.00385457164001993 hsa-miR-194-5p PPP3CA 1.8992998339217 3.76507853301977e-10 -0.281979431665802 0.0843014975757299 MirTarget -0.17070662815415 7.35898582017249e-12 hsa-miR-195-3p CASP3 -0.658653229922836 0.0142127125129199 0.535535897161408 4.31594916615815e-05 MirTarget -0.0535627235455014 0.0267330415592061 hsa-miR-19a-3p PRKACB 3.42309334186656 3.02671914353412e-28 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.217127685863828 2.72225260525319e-11 hsa-miR-19a-3p CASP10 3.42309334186656 3.02671914353412e-28 0.0928615128292813 0.717578504954206 MirTarget;mirMAP -0.0760692924707616 0.0420182085082128 hsa-miR-19a-3p CSF2RB 3.42309334186656 3.02671914353412e-28 -0.739086291347396 0.0696045958228138 MirTarget -0.217107868095224 0.00024429476771933 hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 hsa-miR-19b-3p CSF2RB 2.49529833021187 1.57028265846699e-23 -0.739086291347396 0.0696045958228138 MirTarget -0.339753464615837 5.03583434435228e-06 hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 hsa-miR-200a-3p PRKACB 4.59434485520731 6.38952518573476e-18 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.0898539859960936 5.20182026041999e-06 hsa-miR-200b-3p PRKACB 3.78235093249346 3.18343003239465e-14 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan -0.079282880201862 0.000208224082323168 hsa-miR-200c-3p PRKACB 3.50132673580082 2.42716349086937e-15 -1.11910356116881 7.24897707751757e-07 MirTarget;miRNATAP -0.125201076382777 1.50017445380767e-07 hsa-miR-20a-3p CAPN2 2.92621109947706 2.49504904635375e-17 -0.422341253524924 0.0913287396375096 MirTarget -0.115847953441966 0.000784753626422282 hsa-miR-20a-3p ENDOD1 2.92621109947706 2.49504904635375e-17 -0.331902287589133 0.146465367778401 MirTarget -0.114606991724655 0.000269835101992473 hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 hsa-miR-20a-5p MAP3K14 3.15577933619191 4.19753346442454e-25 -0.929542138683687 1.31735308419243e-05 MirTarget -0.0880882641958642 0.00623057533379648 hsa-miR-20b-5p IL1RAP 2.07706563022469 1.10107236083433e-05 0.687376288697117 0.0561773808581464 MirTarget -0.178499755018748 7.64252091780409e-07 hsa-miR-2110 PRKACB 1.16625590651194 6.4784195289885e-05 -1.11910356116881 7.24897707751757e-07 MirTarget -0.106141262528439 0.00882154187258127 hsa-miR-2110 MAP3K14 1.16625590651194 6.4784195289885e-05 -0.929542138683687 1.31735308419243e-05 MirTarget -0.119162411446147 0.00175262129581408 hsa-miR-2110 CFLAR 1.16625590651194 6.4784195289885e-05 -0.231925856222684 0.202844044313639 MirTarget -0.0902714497028716 0.00504188584599931 hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 hsa-miR-24-3p EXOG 0.99989036772428 1.35595013650376e-07 0.140143801213435 0.400245351651598 MirTarget -0.0949040516743045 0.0248084041148335 hsa-miR-26a-2-3p ATM 0.823520019989974 0.00017092160823769 -0.694304374354523 1.11905560067279e-05 MirTarget -0.118965349103283 0.000759103078575479 hsa-miR-26b-5p ATM 0.885393662798425 3.2116297961629e-06 -0.694304374354523 1.11905560067279e-05 MirTarget -0.112936121726645 0.00532953311791061 hsa-miR-26b-5p PPP3CB 0.885393662798425 3.2116297961629e-06 -1.03671584843429 6.12489584217064e-15 MirTarget;miRNATAP -0.129362759155204 0.000196474595826764 hsa-miR-29b-2-5p CHUK 0.910668640983475 0.00666655585493488 -0.123960303858583 0.302722046952969 MirTarget -0.105463511044412 4.36313837727314e-10 hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 hsa-miR-29c-3p IL1RAP -0.00968972577705429 0.97099586346872 0.687376288697117 0.0561773808581464 MirTarget;miRNATAP -0.316780772059122 1.15292735023863e-06 hsa-miR-29c-3p TNFRSF1A -0.00968972577705429 0.97099586346872 -0.091878962870898 0.598653562583393 MirTarget;miRNATAP -0.0792717292927637 0.0126141889734666 hsa-miR-301a-3p IL1RAP 2.81024345929638 2.29784847962242e-17 0.687376288697117 0.0561773808581464 MirTarget -0.151958204710121 0.00446392491079674 hsa-miR-301a-3p ENDOD1 2.81024345929638 2.29784847962242e-17 -0.331902287589133 0.146465367778401 MirTarget -0.134710930709202 6.44707125829365e-05 hsa-miR-3065-5p NFKBIA 2.74629919868982 1.86846589298284e-08 -0.720709911772914 0.00030878082790516 MirTarget -0.0530646061776299 0.0269707218151739 hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 hsa-miR-3065-5p PRKACB 2.74629919868982 1.86846589298284e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.103807774563958 0.000132862723321062 hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 24293274 MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS PIK3CD and BCL2 colorectal cancer hsa-miR-30b-3p CSF2RB 0.834142820354026 0.000972582820878813 -0.739086291347396 0.0696045958228138 MirTarget -0.473179222241933 7.9171965820414e-10 hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 24293274 MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS PIK3CD and BCL2 colorectal cancer hsa-miR-30b-5p PPP3R1 0.800822374912712 0.000133601914525413 -0.0284423401171923 0.760566460331176 MirTarget -0.0615153401490221 0.00393582602697426 hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 hsa-miR-30c-5p PPP3R1 0.778774633108 0.000285599212429136 -0.0284423401171923 0.760566460331176 MirTarget;miRNATAP -0.0910480965301957 1.09868049452331e-05 hsa-miR-30d-3p IL1B 0.977747550180601 4.3048212205381e-05 0.039301070315787 0.942663363341787 MirTarget -0.351425913519885 0.00142656977660209 hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 hsa-miR-30d-5p PPP3R1 0.675423997639582 0.00270618816039773 -0.0284423401171923 0.760566460331176 MirTarget;miRNATAP -0.0563515897046211 0.00462239757740787 hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 hsa-miR-30e-5p PPP3R1 1.23904909539663 1.35561917122157e-09 -0.0284423401171923 0.760566460331176 MirTarget -0.0867370933489975 5.51029022440179e-05 hsa-miR-320a IL1RAP 0.438165828017084 0.0390159073347133 0.687376288697117 0.0561773808581464 MirTarget;PITA;miRanda -0.190631832000772 0.0213993725591207 hsa-miR-326 PPP3CB 0.715313016136042 0.0610265683213359 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.0835817880449422 1.27907495308049e-06 hsa-miR-330-3p PRKACB 0.876747334239085 0.00073709016089703 -1.11910356116881 7.24897707751757e-07 MirTarget -0.0839496029016369 0.0489634749130281 hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 hsa-miR-330-5p PPP3CB 1.15100069700871 4.85551805046014e-07 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRanda -0.122279132326624 1.90117350044819e-05 hsa-miR-331-3p MAP3K14 2.28379581858927 1.99663919173155e-18 -0.929542138683687 1.31735308419243e-05 MirTarget -0.177987296479208 2.93504280390057e-06 hsa-miR-335-3p PPP3CA 3.08791651139852 5.31309869723517e-12 -0.281979431665802 0.0843014975757299 MirTarget -0.0578428183849171 0.000713654659827143 hsa-miR-335-5p CASP7 1.77247705492746 2.22457658872091e-06 0.211539196871581 0.203476830450442 MirTarget -0.0719742808793655 0.000654118920465733 hsa-miR-338-5p XIAP -0.577691606146419 0.0472212680542825 0.0185824727941606 0.900456705596673 MirTarget;mirMAP -0.051019843899449 0.04029518680719 hsa-miR-33a-3p PPP3CA 1.72765312072219 1.51784443453521e-07 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP;miRNATAP -0.0920673109692904 0.000382894111423911 hsa-miR-345-5p MAP3K14 3.63532310411307 2.2698112107996e-21 -0.929542138683687 1.31735308419243e-05 MirTarget -0.0817123444460956 0.00153484105183177 hsa-miR-34a-5p MAP3K14 1.9016323452565 1.43092834643601e-14 -0.929542138683687 1.31735308419243e-05 MirTarget -0.168509021928338 3.5079349902853e-05 hsa-miR-34c-3p PPP3CB 2.41359195938096 3.46966584087088e-10 -1.03671584843429 6.12489584217064e-15 MirTarget -0.0659089832974402 0.000154038201668703 hsa-miR-3607-3p PIK3R1 2.68532138541128 5.66716351955047e-14 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.0715397351064048 0.0310087142370623 hsa-miR-3607-3p PPP3CA 2.68532138541128 5.66716351955047e-14 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP;miRNATAP -0.0675434123943502 0.00209514647933572 hsa-miR-3607-3p ENDOD1 2.68532138541128 5.66716351955047e-14 -0.331902287589133 0.146465367778401 MirTarget;miRNATAP -0.108599729502635 0.000404026567759276 hsa-miR-361-5p ENDOD1 0.971859117235239 5.30236555707088e-09 -0.331902287589133 0.146465367778401 MirTarget;miRanda -0.339022925897406 2.25093949414901e-07 hsa-miR-3613-5p ENDOD1 2.64358387329263 1.0373753017245e-24 -0.331902287589133 0.146465367778401 MirTarget -0.172750734082545 3.09318154778455e-05 hsa-miR-3653-3p PRKACB 1.85886928622326 2.98407490336841e-08 -1.11910356116881 7.24897707751757e-07 MirTarget -0.105612181380441 0.00210192398606289 hsa-miR-3653-3p PPP3CA 1.85886928622326 2.98407490336841e-08 -0.281979431665802 0.0843014975757299 MirTarget -0.0655527569596621 0.00749580252049549 hsa-miR-365a-3p DFFB -0.0388985816963467 0.859114494267351 0.808547923724971 3.00427717245982e-08 MirTarget -0.112300683568728 0.000635832870706886 hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 hsa-miR-374b-3p PPP3CA 0.930487774873495 2.74420094310516e-05 -0.281979431665802 0.0843014975757299 MirTarget -0.09424081105526 0.00818093510006297 hsa-miR-421 IL1RAP 1.17791565395543 6.78526676976629e-06 0.687376288697117 0.0561773808581464 MirTarget;miRanda -0.191353033681468 0.00390232735089893 hsa-miR-423-5p MAP3K14 0.963563145758616 9.86109015204915e-07 -0.929542138683687 1.31735308419243e-05 MirTarget -0.153326623515501 0.003656927634938 hsa-miR-423-5p NGF 0.963563145758616 9.86109015204915e-07 -2.40747957908931 8.29529053936123e-07 MirTarget;miRNATAP -0.803354433746443 1.32594577043773e-11 hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 hsa-miR-429 PRKACB 4.48815175680773 2.44117492218206e-17 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.0781107785224374 8.79409529061615e-05 hsa-miR-450b-5p NFKB1 1.69244418548325 1.68064054148881e-10 -0.64818153460532 4.948433163113e-05 MirTarget;PITA -0.124463449584444 1.35101416784659e-05 hsa-miR-450b-5p PPP3CB 1.69244418548325 1.68064054148881e-10 -1.03671584843429 6.12489584217064e-15 MirTarget;PITA;miRNATAP -0.0950280485274194 0.000101055470981506 hsa-miR-450b-5p ENDOD1 1.69244418548325 1.68064054148881e-10 -0.331902287589133 0.146465367778401 MirTarget;mirMAP -0.0870651294112237 0.0337148188369448 hsa-miR-454-3p IL1RAP 2.47234127820054 1.12878018736016e-21 0.687376288697117 0.0561773808581464 MirTarget -0.134476368406855 0.0422897667701867 hsa-miR-454-3p ENDOD1 2.47234127820054 1.12878018736016e-21 -0.331902287589133 0.146465367778401 MirTarget -0.199178296032197 1.5946167513499e-06 hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 hsa-miR-497-5p CHUK 0.0257087130056286 0.918145413833358 -0.123960303858583 0.302722046952969 MirTarget -0.130303574602807 1.33264117705817e-08 hsa-miR-500a-3p PPP3CC 1.47161373123699 5.30571342631915e-09 -0.895441456978914 1.07671854464434e-07 MirTarget;miRNATAP -0.11299814981742 0.000453955248711429 hsa-miR-501-3p PPP3CC 1.83132758513743 1.10971547702065e-10 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.0952633026086104 0.00081490311004322 hsa-miR-501-3p PPP3CA 1.83132758513743 1.10971547702065e-10 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.114452652427796 2.34298968304304e-05 hsa-miR-502-3p PPP3CC 1.50560877085049 1.2647489756373e-11 -0.895441456978914 1.07671854464434e-07 MirTarget;PITA;miRNATAP -0.137316418088144 0.000157963764790067 hsa-miR-502-3p PPP3CA 1.50560877085049 1.2647489756373e-11 -0.281979431665802 0.0843014975757299 MirTarget;PITA;miRNATAP -0.15529134445823 7.08901270771209e-06 hsa-miR-508-3p NFKB1 1.05493034310846 0.0393857095042515 -0.64818153460532 4.948433163113e-05 MirTarget;PITA;miRNATAP -0.0676608246535208 1.06273087417113e-05 hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 hsa-miR-532-5p CSF2RB 1.55697650978597 1.57884735535196e-11 -0.739086291347396 0.0696045958228138 MirTarget -0.208350232426084 0.0129885839785501 hsa-miR-590-3p PRKACB 2.59289455139753 1.03200520972022e-21 -1.11910356116881 7.24897707751757e-07 MirTarget;PITA;miRanda;miRNATAP -0.20137371596257 3.58630956215221e-07 hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 hsa-miR-625-5p PRKACA 1.42540152147292 1.95797147911206e-06 -0.0623357146206391 0.530117963925869 MirTarget -0.0575476083738286 0.000848124844285933 hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 hsa-miR-651-5p BIRC3 2.32951837918862 1.62508965949028e-11 -1.14878434773067 0.00715931622274468 MirTarget -0.407201062114202 3.04074465541569e-10 hsa-miR-671-5p NFKB1 2.97733652243246 1.21148452344738e-23 -0.64818153460532 4.948433163113e-05 MirTarget -0.0872179046834003 0.00085086206232383 hsa-miR-7-1-3p PPP3CA 1.84950311431067 1.25300363397654e-13 -0.281979431665802 0.0843014975757299 MirTarget;mirMAP -0.119727173710851 9.40140707131449e-05 hsa-miR-766-3p ATM 1.2456012547833 6.44584025471128e-06 -0.694304374354523 1.11905560067279e-05 MirTarget -0.0746375323911624 0.00704981671733787 hsa-miR-874-3p MAP3K14 1.95617235160298 2.0152613104032e-12 -0.929542138683687 1.31735308419243e-05 MirTarget -0.1737967270095 1.57895892349653e-06 hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 hsa-miR-93-5p IL1RAP 3.03961860136032 1.11672209617395e-24 0.687376288697117 0.0561773808581464 MirTarget -0.289274250215671 1.35967607397858e-07 hsa-miR-93-5p MAP3K14 3.03961860136032 1.11672209617395e-24 -0.929542138683687 1.31735308419243e-05 MirTarget -0.141287388297998 1.8190573493729e-05 hsa-miR-98-5p NGF 1.11154309866014 1.24143909012085e-08 -2.40747957908931 8.29529053936123e-07 MirTarget -0.660953034981452 3.88812196488546e-08 hsa-miR-125a-5p BCL2 0.599529391575274 0.0102300147180307 -2.02088083891464 5.5300725103229e-13 PITA -0.204181839304005 0.000647180620809067 hsa-miR-582-5p BCL2 0.609226359812689 0.032988717891497 -2.02088083891464 5.5300725103229e-13 PITA -0.211866972823695 1.29345936711211e-05 hsa-miR-590-5p PPP3CA 3.18300989862077 2.06813568597893e-26 -0.281979431665802 0.0843014975757299 PITA;miRanda;miRNATAP -0.0925111885367781 0.000265103601175037 hsa-miR-320a PPP3R1 0.438165828017084 0.0390159073347133 -0.0284423401171923 0.760566460331176 PITA;miRanda -0.0737824308135289 0.000484362233028493 hsa-miR-362-3p PRKACB 2.0756816987665 3.89026064579331e-12 -1.11910356116881 7.24897707751757e-07 PITA;miRanda;miRNATAP -0.2320492729467 2.29661541166603e-10 hsa-miR-532-5p PRKACB 1.55697650978597 1.57884735535196e-11 -1.11910356116881 7.24897707751757e-07 PITA -0.27784223940084 1.83614058183971e-09 hsa-miR-34c-3p PRKAR2B 2.41359195938096 3.46966584087088e-10 -2.6424142214808 7.30155345842383e-13 PITA;miRNATAP -0.138453766267301 0.00421688779281111 hsa-miR-429 PRKAR2B 4.48815175680773 2.44117492218206e-17 -2.6424142214808 7.30155345842383e-13 PITA;miRanda;miRNATAP -0.186608189782453 1.14936297941293e-08 hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 hsa-miR-576-5p PIK3CA 2.20467023993664 3.4053475193793e-19 -0.151828236462886 0.321284398928338 PITA -0.0902220369392094 0.00169985359471657 hsa-miR-501-5p PPP3CB 1.93654809410041 1.3779381780759e-10 -1.03671584843429 6.12489584217064e-15 PITA;miRNATAP -0.110941325807012 4.19796167603695e-07 hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 hsa-miR-508-3p PIK3R1 1.05493034310846 0.0393857095042515 -1.16357283690918 1.63774086027679e-06 PITA -0.0523898891576641 0.0269689884288959 hsa-miR-362-5p PRKACB 1.59303749908759 9.582675908797e-08 -1.11910356116881 7.24897707751757e-07 PITA -0.194987590184185 6.59081906609811e-08 hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 hsa-miR-200b-3p ENDOD1 3.78235093249346 3.18343003239465e-14 -0.331902287589133 0.146465367778401 TargetScan -0.0993963756164199 2.89212715552139e-06 hsa-let-7a-5p FAS 0.618599506841644 2.76973453058748e-05 -0.893121037137088 0.00675655818216232 TargetScan -0.294996828851615 0.0073114418152214 hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 hsa-miR-96-5p PPP3CA 4.89433085814374 1.92000659886961e-31 -0.281979431665802 0.0843014975757299 TargetScan -0.0953029651395409 6.61378921407754e-08 hsa-miR-17-5p PRKACB 3.2710598467455 9.93128340539455e-27 -1.11910356116881 7.24897707751757e-07 TargetScan -0.195594044734934 5.04690942157379e-09 hsa-miR-141-3p PRKAR1A 5.02396127982626 2.19224509139725e-24 -0.494707246064478 1.09832496534671e-05 TargetScan -0.050291674226767 1.14324675537054e-06 hsa-miR-200b-3p PRKAR2B 3.78235093249346 3.18343003239465e-14 -2.6424142214808 7.30155345842383e-13 TargetScan -0.188581609073265 8.00246180754754e-08 hsa-miR-28-5p PRKAR2A 0.230152919654905 0.0742909586754846 -0.958058230501873 0.00166358416501506 miRanda -0.317354369876665 0.00743076146152275 hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 hsa-miR-107 PRKAR1A 1.30977326593435 1.30372468603965e-11 -0.494707246064478 1.09832496534671e-05 miRanda -0.0662503424746762 0.0174384967046709 hsa-miR-107 CAPN2 1.30977326593435 1.30372468603965e-11 -0.422341253524924 0.0913287396375096 miRanda -0.437052765176765 3.2546933497498e-13 hsa-miR-107 IL1RAP 1.30977326593435 1.30372468603965e-11 0.687376288697117 0.0561773808581464 miRanda -0.33678389768747 0.000139724034766597 hsa-miR-107 PPP3CB 1.30977326593435 1.30372468603965e-11 -1.03671584843429 6.12489584217064e-15 miRanda -0.224024061633064 1.13198598297881e-11 hsa-miR-107 IKBKG 1.30977326593435 1.30372468603965e-11 0.412355551213307 0.00132920442221218 miRanda -0.0831926768626085 0.00863713795776225 hsa-miR-107 CFLAR 1.30977326593435 1.30372468603965e-11 -0.231925856222684 0.202844044313639 miRanda -0.148357712217052 0.000900731169471226 hsa-miR-107 PRKAR2B 1.30977326593435 1.30372468603965e-11 -2.6424142214808 7.30155345842383e-13 miRanda -0.231460940026043 0.0133239826950658 hsa-miR-199a-5p DFFB 0.592984035153911 0.0674836634175293 0.808547923724971 3.00427717245982e-08 miRanda -0.0688499379877952 0.00179014565267308 hsa-miR-199a-5p PIK3R1 0.592984035153911 0.0674836634175293 -1.16357283690918 1.63774086027679e-06 miRanda -0.0767286931099107 0.0366580311456345 hsa-miR-199a-5p EXOG 0.592984035153911 0.0674836634175293 0.140143801213435 0.400245351651598 miRanda -0.0722912928683034 0.00351903545423481 hsa-miR-199a-5p AIFM1 0.592984035153911 0.0674836634175293 0.303056224316474 0.00499225344172376 miRanda -0.0621640883463547 0.00010057893785087 hsa-miR-129-5p TNFSF10 -0.524170159980738 0.222582956006346 0.62151336306871 0.110711377947693 miRanda -0.171605377985452 0.000117006373445903 hsa-miR-139-5p IL1RAP -1.52606598644743 1.20474151350665e-08 0.687376288697117 0.0561773808581464 miRanda -0.216871073158647 0.000708940318255466 hsa-miR-139-5p TNFSF10 -1.52606598644743 1.20474151350665e-08 0.62151336306871 0.110711377947693 miRanda -0.245494690697579 0.000392669662957397 hsa-miR-199b-5p DFFB 0.218704279044827 0.519493319158441 0.808547923724971 3.00427717245982e-08 miRanda -0.0509207371934235 0.0159710867137279 hsa-miR-199b-5p PIK3R1 0.218704279044827 0.519493319158441 -1.16357283690918 1.63774086027679e-06 miRanda -0.0803957217297069 0.02198775664261 hsa-miR-217 CASP8 0.608024397387488 0.199352491710517 0.614672266065446 0.00102927275063291 miRanda -0.0900129994456467 4.15377062363525e-06 hsa-miR-140-5p PPP3CB 0.844753502512594 3.73722278438606e-05 -1.03671584843429 6.12489584217064e-15 miRanda -0.0652127605287475 0.0444357882558287 hsa-miR-140-5p PRKAR2A 0.844753502512594 3.73722278438606e-05 -0.958058230501873 0.00166358416501506 miRanda -0.197853314212427 0.00623596481680405 hsa-miR-140-5p CAPN1 0.844753502512594 3.73722278438606e-05 0.551088466286071 0.000662289657689611 miRanda;miRNATAP -0.0910488640089849 0.0177890103238609 hsa-miR-125a-5p CSF2RB 0.599529391575274 0.0102300147180307 -0.739086291347396 0.0696045958228138 miRanda -0.426358007692611 3.75324813924671e-07 hsa-miR-125a-5p PRKAR2A 0.599529391575274 0.0102300147180307 -0.958058230501873 0.00166358416501506 miRanda -0.37787946708526 1.5675108729139e-09 hsa-miR-125a-5p CFLAR 0.599529391575274 0.0102300147180307 -0.231925856222684 0.202844044313639 miRanda -0.225494307449277 1.29185039963355e-09 hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 hsa-miR-125a-3p NGF 1.24490295132072 5.26925231010328e-06 -2.40747957908931 8.29529053936123e-07 miRanda -0.250797549188537 0.00395961103629666 hsa-miR-127-3p RIPK1 -0.6279281852298 0.0400829468424132 -0.323726292412104 0.00484264630910019 miRanda -0.0666155216328224 0.000228644247246619 hsa-miR-193a-3p IRAK4 1.60460546928078 2.86169793322984e-07 0.189766326709953 0.138288179984644 miRanda -0.0643946347872097 0.000922054210671554 hsa-miR-193a-3p PRKACB 1.60460546928078 2.86169793322984e-07 -1.11910356116881 7.24897707751757e-07 miRanda -0.185097829574766 8.14913568795542e-08 hsa-miR-320a TNF 0.438165828017084 0.0390159073347133 0.168287325738871 0.711715304997615 miRanda -0.394855461451853 0.0001481103227567 hsa-miR-320a NGF 0.438165828017084 0.0390159073347133 -2.40747957908931 8.29529053936123e-07 miRanda -0.444107483987704 8.7035614427142e-05 hsa-miR-320a CAPN2 0.438165828017084 0.0390159073347133 -0.422341253524924 0.0913287396375096 miRanda -0.277145040818614 1.10455221350909e-06 hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 hsa-miR-320a CFLAR 0.438165828017084 0.0390159073347133 -0.231925856222684 0.202844044313639 miRanda -0.187083028324921 6.26248969577351e-06 hsa-miR-320a PPP3CA 0.438165828017084 0.0390159073347133 -0.281979431665802 0.0843014975757299 miRanda -0.0836438650578148 0.0256799522502136 hsa-miR-320a PPP3CB 0.438165828017084 0.0390159073347133 -1.03671584843429 6.12489584217064e-15 miRanda -0.133683103961461 1.89473747516991e-05 hsa-miR-320a IRAK3 0.438165828017084 0.0390159073347133 -1.61324599744624 9.44362061411831e-07 miRanda -0.177667111226484 0.0204343172413913 hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 hsa-miR-361-5p FAS 0.971859117235239 5.30236555707088e-09 -0.893121037137088 0.00675655818216232 miRanda -0.765596610913641 1.34005865686507e-16 hsa-miR-361-5p TNF 0.971859117235239 5.30236555707088e-09 0.168287325738871 0.711715304997615 miRanda -0.363396990950332 0.00589234482466197 hsa-miR-361-5p IL1RAP 0.971859117235239 5.30236555707088e-09 0.687376288697117 0.0561773808581464 miRanda -0.278506548425349 0.00771310516085455 hsa-miR-361-5p TNFSF10 0.971859117235239 5.30236555707088e-09 0.62151336306871 0.110711377947693 miRanda -0.438574912638159 9.76217270913905e-05 hsa-miR-361-5p PPP3CC 0.971859117235239 5.30236555707088e-09 -0.895441456978914 1.07671854464434e-07 miRanda -0.275565592476708 1.65394541713718e-08 hsa-miR-361-5p IL1R1 0.971859117235239 5.30236555707088e-09 -0.754392858754991 0.00819157634786962 miRanda -0.498319115587793 9.79775892914811e-10 hsa-miR-361-5p PPP3CA 0.971859117235239 5.30236555707088e-09 -0.281979431665802 0.0843014975757299 miRanda -0.0937552829513574 0.0478432981986854 hsa-miR-361-5p IRAK3 0.971859117235239 5.30236555707088e-09 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.521687719341155 4.54616848788055e-08 hsa-miR-361-5p PPP3CB 0.971859117235239 5.30236555707088e-09 -1.03671584843429 6.12489584217064e-15 miRanda -0.319599472524393 7.32960352437588e-17 hsa-miR-361-5p PRKAR2A 0.971859117235239 5.30236555707088e-09 -0.958058230501873 0.00166358416501506 miRanda -0.193183161655923 0.0297877653345942 hsa-miR-361-5p PRKACB 0.971859117235239 5.30236555707088e-09 -1.11910356116881 7.24897707751757e-07 miRanda -0.178114095699739 0.00724869450353386 hsa-miR-361-5p PRKAR2B 0.971859117235239 5.30236555707088e-09 -2.6424142214808 7.30155345842383e-13 miRanda -0.392322571223063 0.000345653351775711 hsa-miR-361-5p TNFRSF10C 0.971859117235239 5.30236555707088e-09 -0.499439470720603 0.192162849023382 miRanda -0.259516100289945 0.019605241486501 hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 hsa-miR-362-3p ATM 2.0756816987665 3.89026064579331e-12 -0.694304374354523 1.11905560067279e-05 miRanda -0.112278812357676 1.35632724301173e-05 hsa-miR-375 PPP3CC 1.13910305294079 0.0512283522214186 -0.895441456978914 1.07671854464434e-07 miRanda -0.0513795275892868 0.000252166740284317 hsa-miR-330-5p IRAK3 1.15100069700871 4.85551805046014e-07 -1.61324599744624 9.44362061411831e-07 miRanda -0.259104342543673 0.000204001879358591 hsa-miR-342-3p PRKAR1A 1.49115144672245 1.43879249744621e-07 -0.494707246064478 1.09832496534671e-05 miRanda -0.0995115859475151 1.24057096388708e-07 hsa-miR-342-3p PPP3CB 1.49115144672245 1.43879249744621e-07 -1.03671584843429 6.12489584217064e-15 miRanda -0.0568247087163028 0.0139729208657623 hsa-miR-326 IRAK3 0.715313016136042 0.0610265683213359 -1.61324599744624 9.44362061411831e-07 miRanda -0.11150566898433 0.00855072371022298 hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 hsa-miR-324-5p IRAK3 2.95683728155095 1.32960514360912e-20 -1.61324599744624 9.44362061411831e-07 miRanda -0.351256984620892 8.27603616099315e-14 hsa-miR-324-5p FASLG 2.95683728155095 1.32960514360912e-20 -0.196180452389551 0.711804379159628 miRanda -0.190742358117509 0.0133843611744564 hsa-miR-324-5p ATM 2.95683728155095 1.32960514360912e-20 -0.694304374354523 1.11905560067279e-05 miRanda -0.111813212915851 1.04521240946738e-06 hsa-miR-339-5p PRKACB 2.68710938429893 3.03134080808154e-16 -1.11910356116881 7.24897707751757e-07 miRanda -0.145165623596419 6.50854523117634e-06 hsa-miR-339-5p PPP3CB 2.68710938429893 3.03134080808154e-16 -1.03671584843429 6.12489584217064e-15 miRanda -0.129274316344838 1.00359131009696e-11 hsa-miR-339-5p ATM 2.68710938429893 3.03134080808154e-16 -0.694304374354523 1.11905560067279e-05 miRanda -0.0783740431328076 0.000503029149778795 hsa-miR-429 NGF 4.48815175680773 2.44117492218206e-17 -2.40747957908931 8.29529053936123e-07 miRanda -0.382290239888962 2.67088438561565e-20 hsa-miR-429 NFKB1 4.48815175680773 2.44117492218206e-17 -0.64818153460532 4.948433163113e-05 miRanda;miRNATAP -0.084428678890444 9.86979421664935e-10 hsa-miR-429 TNFSF10 4.48815175680773 2.44117492218206e-17 0.62151336306871 0.110711377947693 miRanda -0.134275255476822 7.66062319152758e-05 hsa-miR-429 PPP3CB 4.48815175680773 2.44117492218206e-17 -1.03671584843429 6.12489584217064e-15 miRanda -0.104170748345545 1.10824048087982e-19 hsa-miR-429 IRAK3 4.48815175680773 2.44117492218206e-17 -1.61324599744624 9.44362061411831e-07 miRanda -0.226880985621525 8.77354448488068e-16 hsa-miR-429 ENDOD1 4.48815175680773 2.44117492218206e-17 -0.331902287589133 0.146465367778401 miRanda;miRNATAP -0.0888835539583952 7.43247312270928e-06 hsa-miR-491-5p FAS 0.615770352820862 0.0418295628761654 -0.893121037137088 0.00675655818216232 miRanda -0.202143347610942 0.000355416125267629 hsa-miR-491-5p IL1R1 0.615770352820862 0.0418295628761654 -0.754392858754991 0.00819157634786962 miRanda -0.0967007012442384 0.0494251813743173 hsa-miR-491-5p CAPN1 0.615770352820862 0.0418295628761654 0.551088466286071 0.000662289657689611 miRanda -0.0575224474843367 0.0394049148138824 hsa-miR-146b-5p IKBKB 1.75587235896724 1.15724631266659e-07 -0.00227190214342876 0.988714147115007 miRanda -0.12253940493918 7.13410135054121e-08 hsa-miR-496 RIPK1 0.46914638405371 0.145980484291736 -0.323726292412104 0.00484264630910019 miRanda -0.0556116308771314 0.00155595831044226 hsa-miR-455-5p ATM 2.2582442061694 1.43472128037398e-13 -0.694304374354523 1.11905560067279e-05 miRanda -0.106749319544671 1.15313735793322e-05 hsa-miR-590-5p PRKAR1A 3.18300989862077 2.06813568597893e-26 -0.494707246064478 1.09832496534671e-05 miRanda -0.0941282814950952 6.4557854682977e-08 hsa-miR-590-5p FAS 3.18300989862077 2.06813568597893e-26 -0.893121037137088 0.00675655818216232 miRanda -0.26445516527792 2.22188286955534e-07 hsa-miR-590-5p CAPN2 3.18300989862077 2.06813568597893e-26 -0.422341253524924 0.0913287396375096 miRanda -0.158328870843835 4.56868205430932e-05 hsa-miR-590-5p BCL2 3.18300989862077 2.06813568597893e-26 -2.02088083891464 5.5300725103229e-13 miRanda -0.311666149337473 1.27642835632825e-12 hsa-miR-590-5p PIK3R3 3.18300989862077 2.06813568597893e-26 -0.627704444396048 0.00578594022892978 miRanda -0.0814160343557343 0.022364395955343 hsa-miR-590-5p PIK3CA 3.18300989862077 2.06813568597893e-26 -0.151828236462886 0.321284398928338 miRanda -0.0540411360316273 0.0234365949631173 hsa-miR-590-5p PRKACB 3.18300989862077 2.06813568597893e-26 -1.11910356116881 7.24897707751757e-07 miRanda -0.22361088291547 1.69108646897883e-10 hsa-miR-590-5p TNFRSF10D 3.18300989862077 2.06813568597893e-26 -1.21952127016643 0.000173029902186277 miRanda -0.104917038709611 0.0402849542401198 hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 hsa-miR-590-3p PRKAR1A 2.59289455139753 1.03200520972022e-21 -0.494707246064478 1.09832496534671e-05 miRanda;mirMAP -0.0841522998475742 1.81567040243572e-05 hsa-miR-590-3p NFKB1 2.59289455139753 1.03200520972022e-21 -0.64818153460532 4.948433163113e-05 miRanda;mirMAP -0.0662524408941836 0.018526754364778 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung cancer hsa-miR-590-3p CAPN2 2.59289455139753 1.03200520972022e-21 -0.422341253524924 0.0913287396375096 miRanda -0.14408856443896 0.00096528080440921 hsa-miR-590-3p BCL2 2.59289455139753 1.03200520972022e-21 -2.02088083891464 5.5300725103229e-13 miRanda;mirMAP -0.268687896594515 6.89769791912093e-08 hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 hsa-miR-590-3p TNFRSF1A 2.59289455139753 1.03200520972022e-21 -0.091878962870898 0.598653562583393 miRanda -0.0906430094161927 0.00287641674359409 hsa-miR-590-3p IL1R1 2.59289455139753 1.03200520972022e-21 -0.754392858754991 0.00819157634786962 miRanda;miRNATAP -0.268420918425037 5.48871203423167e-08 hsa-miR-590-3p PPP3CA 2.59289455139753 1.03200520972022e-21 -0.281979431665802 0.0843014975757299 miRanda;mirMAP -0.0703201763483185 0.0137359066554011 hsa-miR-590-3p PPP3CB 2.59289455139753 1.03200520972022e-21 -1.03671584843429 6.12489584217064e-15 miRanda -0.160737546369274 6.57567642585996e-12 hsa-miR-590-3p PRKACA 2.59289455139753 1.03200520972022e-21 -0.0623357146206391 0.530117963925869 miRanda -0.0531211945850324 0.00199296030113284 hsa-miR-590-3p PIK3CA 2.59289455139753 1.03200520972022e-21 -0.151828236462886 0.321284398928338 miRanda;mirMAP -0.055368158239037 0.0383091191263138 hsa-miR-590-3p IRAK3 2.59289455139753 1.03200520972022e-21 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.260308402381023 6.83807609723304e-06 hsa-miR-590-3p ENDOD1 2.59289455139753 1.03200520972022e-21 -0.331902287589133 0.146465367778401 miRanda -0.150399397562406 0.00015650300787438 hsa-miR-590-3p ATM 2.59289455139753 1.03200520972022e-21 -0.694304374354523 1.11905560067279e-05 miRanda;mirMAP -0.147925962529486 7.50176131513898e-08 hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 hsa-miR-421 CAPN2 1.17791565395543 6.78526676976629e-06 -0.422341253524924 0.0913287396375096 miRanda -0.251126865613037 3.2279294019974e-08 hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 hsa-miR-421 IRAK4 1.17791565395543 6.78526676976629e-06 0.189766326709953 0.138288179984644 miRanda -0.0654911978686281 0.00524253352144947 hsa-miR-421 IRAK3 1.17791565395543 6.78526676976629e-06 -1.61324599744624 9.44362061411831e-07 miRanda;mirMAP -0.284717839538607 2.87793406686902e-06 hsa-miR-421 PPP3CB 1.17791565395543 6.78526676976629e-06 -1.03671584843429 6.12489584217064e-15 miRanda -0.107753543524587 1.70411972807069e-05 hsa-miR-421 RIPK1 1.17791565395543 6.78526676976629e-06 -0.323726292412104 0.00484264630910019 miRanda;mirMAP -0.0702585068939242 0.000847981474331101 hsa-miR-421 CFLAR 1.17791565395543 6.78526676976629e-06 -0.231925856222684 0.202844044313639 miRanda -0.14658086248006 1.02286863777652e-05 hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 hsa-miR-320b PRKAR1A 1.55692969039548 1.41071034251915e-08 -0.494707246064478 1.09832496534671e-05 miRanda -0.0507406473741568 0.00977763068457851 hsa-miR-320b NGF 1.55692969039548 1.41071034251915e-08 -2.40747957908931 8.29529053936123e-07 miRanda -0.423772071383533 6.50389232533904e-07 hsa-miR-320b CAPN2 1.55692969039548 1.41071034251915e-08 -0.422341253524924 0.0913287396375096 miRanda -0.172007383267619 6.96931261650163e-05 hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 hsa-miR-320b CFLAR 1.55692969039548 1.41071034251915e-08 -0.231925856222684 0.202844044313639 miRanda -0.0850224093827846 0.00710261250326669 hsa-miR-320b PPP3CA 1.55692969039548 1.41071034251915e-08 -0.281979431665802 0.0843014975757299 miRanda -0.0747517149496106 0.00834116436794549 hsa-miR-320b PPP3CB 1.55692969039548 1.41071034251915e-08 -1.03671584843429 6.12489584217064e-15 miRanda -0.157984627594008 1.12882018634839e-11 hsa-miR-320b IRAK3 1.55692969039548 1.41071034251915e-08 -1.61324599744624 9.44362061411831e-07 miRanda -0.254713964263451 9.45719838918495e-06 hsa-miR-217 CASP10 0.608024397387488 0.199352491710517 0.0928615128292813 0.717578504954206 mirMAP -0.060163005705642 0.0254636246766209 hsa-miR-744-3p CASP10 2.7517405670917 4.22040908411227e-14 0.0928615128292813 0.717578504954206 mirMAP -0.141817879498213 1.49202617610436e-05 hsa-miR-33a-3p CASP10 1.72765312072219 1.51784443453521e-07 0.0928615128292813 0.717578504954206 mirMAP -0.104979467957295 0.0102694577013009 hsa-miR-129-5p CASP10 -0.524170159980738 0.222582956006346 0.0928615128292813 0.717578504954206 mirMAP -0.0853411379353378 0.00369536196704936 hsa-miR-374a-3p CASP10 0.533309330504947 0.00192918429705142 0.0928615128292813 0.717578504954206 mirMAP -0.20364512927735 0.00522441741668315 hsa-miR-421 CASP10 1.17791565395543 6.78526676976629e-06 0.0928615128292813 0.717578504954206 mirMAP -0.157687882200134 0.000810622936052014 hsa-miR-103a-2-5p CFLAR 2.47599305985086 7.933028987326e-11 -0.231925856222684 0.202844044313639 mirMAP -0.0666589592747516 0.00909550762581571 hsa-miR-130b-3p CFLAR 3.5350292994509 1.73934183852569e-27 -0.231925856222684 0.202844044313639 mirMAP -0.145696928019461 4.93456456035999e-09 hsa-miR-15b-5p CFLAR 1.57112623124278 9.14247846750597e-13 -0.231925856222684 0.202844044313639 mirMAP -0.101026335268494 0.00988724932214317 hsa-miR-301a-3p CFLAR 2.81024345929638 2.29784847962242e-17 -0.231925856222684 0.202844044313639 mirMAP -0.168172963252665 2.02871497274292e-10 hsa-miR-30b-3p CFLAR 0.834142820354026 0.000972582820878813 -0.231925856222684 0.202844044313639 mirMAP -0.176108209676801 3.44450275553177e-07 hsa-miR-454-3p CFLAR 2.47234127820054 1.12878018736016e-21 -0.231925856222684 0.202844044313639 mirMAP -0.118171420962222 0.000376451937569571 hsa-miR-484 CFLAR 1.81844463411787 1.82951571230938e-15 -0.231925856222684 0.202844044313639 mirMAP -0.145571572520698 9.02314434337118e-05 hsa-miR-186-5p CFLAR 1.47445398888668 3.0781726595413e-15 -0.231925856222684 0.202844044313639 mirMAP -0.161290321910154 0.000432850514170424 hsa-let-7a-3p PRKAR2B 1.42015538786275 7.03375209382654e-13 -2.6424142214808 7.30155345842383e-13 mirMAP -0.413974785318944 4.57144286032067e-06 hsa-let-7b-3p PRKAR2B 0.868207752019623 1.30460056774366e-05 -2.6424142214808 7.30155345842383e-13 mirMAP -0.302979006252105 0.000989045305242101 hsa-let-7f-1-3p PRKAR2B 1.55054488387679 7.31326775537952e-11 -2.6424142214808 7.30155345842383e-13 mirMAP -0.215230558088131 0.00574393729251686 hsa-miR-186-5p PRKAR2B 1.47445398888668 3.0781726595413e-15 -2.6424142214808 7.30155345842383e-13 mirMAP -0.321761961201559 0.000772863763366889 hsa-miR-335-3p PRKAR2B 3.08791651139852 5.31309869723517e-12 -2.6424142214808 7.30155345842383e-13 mirMAP -0.203129063258021 2.53679260832495e-07 hsa-miR-450b-5p PRKAR2B 1.69244418548325 1.68064054148881e-10 -2.6424142214808 7.30155345842383e-13 mirMAP;miRNATAP -0.137048468131565 0.0441799949298598 hsa-miR-944 PRKAR2B 2.91186649218281 1.31574753528144e-06 -2.6424142214808 7.30155345842383e-13 mirMAP -0.296024663700539 7.0750363003914e-24 hsa-miR-664a-3p BIRC3 0.634721925861133 0.00520070178640421 -1.14878434773067 0.00715931622274468 mirMAP -0.30056739615358 0.00101453991329218 hsa-miR-143-3p IKBKG -2.5789192793377 1.55518999614836e-14 0.412355551213307 0.00132920442221218 mirMAP -0.0507873884733058 0.00461428633244773 hsa-miR-432-5p IKBKG -0.128200716359323 0.676832757701632 0.412355551213307 0.00132920442221218 mirMAP -0.0603898010677136 0.00305252418998825 hsa-miR-141-3p IRAK3 5.02396127982626 2.19224509139725e-24 -1.61324599744624 9.44362061411831e-07 mirMAP -0.237412262860539 1.63026403262395e-15 hsa-miR-148b-5p IRAK3 2.18024067300781 2.84770452413262e-14 -1.61324599744624 9.44362061411831e-07 mirMAP -0.337307253672073 2.92190660652579e-09 hsa-miR-16-1-3p IRAK3 2.56983217111073 3.02262181237943e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.217915579974644 0.000117601397835657 hsa-miR-16-2-3p IRAK3 2.31623086727196 4.29838149388188e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.241605828325225 7.32339791852684e-05 hsa-miR-186-5p IRAK3 1.47445398888668 3.0781726595413e-15 -1.61324599744624 9.44362061411831e-07 mirMAP -0.520105007237852 3.24671297125945e-10 hsa-miR-188-5p IRAK3 2.52825126596644 6.78099435999778e-14 -1.61324599744624 9.44362061411831e-07 mirMAP -0.280672215201693 8.08975252886038e-09 hsa-miR-200a-3p IRAK3 4.59434485520731 6.38952518573476e-18 -1.61324599744624 9.44362061411831e-07 mirMAP -0.235202683293506 3.59384388778503e-17 hsa-miR-205-5p IRAK3 4.1389800495524 2.05488295686453e-12 -1.61324599744624 9.44362061411831e-07 mirMAP -0.0755807806905257 0.0044470699147548 hsa-miR-20a-3p IRAK3 2.92621109947706 2.49504904635375e-17 -1.61324599744624 9.44362061411831e-07 mirMAP -0.293239164748252 8.31399787795003e-11 hsa-miR-224-3p IRAK3 1.87536386559317 6.15140969394846e-05 -1.61324599744624 9.44362061411831e-07 mirMAP -0.079493083612545 0.0264165935977338 hsa-miR-25-3p IRAK3 1.36472605225697 4.83790725935681e-11 -1.61324599744624 9.44362061411831e-07 mirMAP -0.486782496706321 8.60201865878405e-11 hsa-miR-29b-2-5p IRAK3 0.910668640983475 0.00666655585493488 -1.61324599744624 9.44362061411831e-07 mirMAP -0.225454736994109 2.14568944357781e-06 hsa-miR-3200-3p IRAK3 2.70510522077868 1.90469509928484e-08 -1.61324599744624 9.44362061411831e-07 mirMAP -0.268417657140478 2.21173595642778e-15 hsa-miR-32-5p IRAK3 2.34056473219422 6.24134585974322e-20 -1.61324599744624 9.44362061411831e-07 mirMAP -0.328194671825066 3.51347516406062e-08 hsa-miR-330-3p IRAK3 0.876747334239085 0.00073709016089703 -1.61324599744624 9.44362061411831e-07 mirMAP -0.227895460995676 0.000226010351889401 hsa-miR-33a-5p IRAK3 3.79671563098419 1.15966309820345e-18 -1.61324599744624 9.44362061411831e-07 mirMAP -0.263603831431637 4.66146319128517e-12 hsa-miR-363-3p IRAK3 1.50575300026701 0.00020976164678918 -1.61324599744624 9.44362061411831e-07 mirMAP -0.176370169000037 6.63445963863957e-06 hsa-miR-450b-5p IRAK3 1.69244418548325 1.68064054148881e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.268551151836279 5.89719539852997e-06 hsa-miR-501-5p IRAK3 1.93654809410041 1.3779381780759e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.296835101027037 2.37939188611957e-08 hsa-miR-505-3p IRAK3 1.45322244209148 8.86597629645867e-10 -1.61324599744624 9.44362061411831e-07 mirMAP -0.253884740154823 0.000142204760654013 hsa-miR-589-3p IRAK3 2.51971841868825 2.39125940264107e-11 -1.61324599744624 9.44362061411831e-07 mirMAP -0.232633878464469 7.63598244506855e-07 hsa-miR-590-5p IRAK3 3.18300989862077 2.06813568597893e-26 -1.61324599744624 9.44362061411831e-07 mirMAP -0.329211940694564 1.08651193118683e-10 hsa-miR-660-5p IRAK3 1.82692095272076 1.92040083607196e-13 -1.61324599744624 9.44362061411831e-07 mirMAP -0.313405787681777 5.64080920953627e-07 hsa-miR-7-1-3p IRAK3 1.84950311431067 1.25300363397654e-13 -1.61324599744624 9.44362061411831e-07 mirMAP -0.274128018063691 1.16665950411267e-05 hsa-miR-92a-3p IRAK3 2.06460102658973 1.44784291084757e-19 -1.61324599744624 9.44362061411831e-07 mirMAP -0.516491089062745 4.20857360213128e-15 hsa-miR-944 IRAK3 2.91186649218281 1.31574753528144e-06 -1.61324599744624 9.44362061411831e-07 mirMAP -0.0576020753726856 0.035011913451365 hsa-miR-335-3p IRAK3 3.08791651139852 5.31309869723517e-12 -1.61324599744624 9.44362061411831e-07 mirMAP -0.15174104397747 1.29116664173015e-05 hsa-miR-15b-3p CSF2RB 2.33847028227712 4.29662877950836e-19 -0.739086291347396 0.0696045958228138 mirMAP -0.410621118990345 8.08744457322504e-09 hsa-miR-186-5p CSF2RB 1.47445398888668 3.0781726595413e-15 -0.739086291347396 0.0696045958228138 mirMAP -0.36439054422735 0.000394153164171476 hsa-miR-452-3p CSF2RB 2.42521958420768 4.08754552781156e-07 -0.739086291347396 0.0696045958228138 mirMAP -0.135652814910086 0.000851140820930795 hsa-miR-125b-2-3p XIAP -1.83175829351767 2.94917958974528e-05 0.0185824727941606 0.900456705596673 mirMAP -0.068986973089532 2.57273420660549e-05 hsa-miR-140-3p XIAP 0.0608890720479334 0.727716871248724 0.0185824727941606 0.900456705596673 mirMAP -0.0916376618716535 0.0278327492197441 hsa-miR-142-5p XIAP 1.17581605694506 0.0018174701991234 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.0648820033940148 0.000573423539803553 hsa-miR-143-5p XIAP 0.374623042221941 0.168857981158196 0.0185824727941606 0.900456705596673 mirMAP -0.0874158389674923 0.000897364406171057 hsa-miR-146b-5p XIAP 1.75587235896724 1.15724631266659e-07 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.100792988978608 1.7835560220266e-06 hsa-miR-195-3p XIAP -0.658653229922836 0.0142127125129199 0.0185824727941606 0.900456705596673 mirMAP -0.109312331752852 5.17755048006399e-05 hsa-miR-19a-3p XIAP 3.42309334186656 3.02671914353412e-28 0.0185824727941606 0.900456705596673 mirMAP -0.0545370952818166 0.0114152600633907 hsa-miR-19b-3p XIAP 2.49529833021187 1.57028265846699e-23 0.0185824727941606 0.900456705596673 mirMAP -0.0548312373778768 0.0444009935433898 hsa-miR-26a-2-3p XIAP 0.823520019989974 0.00017092160823769 0.0185824727941606 0.900456705596673 mirMAP -0.103081650553247 0.0016975998669049 hsa-miR-29a-5p XIAP 1.46749674755271 3.34605004270294e-07 0.0185824727941606 0.900456705596673 mirMAP -0.0792153377176069 0.00231305845328066 hsa-miR-340-5p XIAP 0.30282999308409 0.157744789519131 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.0868516659003001 0.00993294704670108 hsa-miR-500a-5p XIAP 1.72110365584658 3.0807246212659e-10 0.0185824727941606 0.900456705596673 mirMAP;miRNATAP -0.07723947944116 0.00264910124056209 hsa-miR-766-3p XIAP 1.2456012547833 6.44584025471128e-06 0.0185824727941606 0.900456705596673 mirMAP -0.0589738595963076 0.0220523189556316 hsa-miR-92b-3p XIAP 1.20409245530001 3.41055816361655e-06 0.0185824727941606 0.900456705596673 mirMAP -0.0785656779092584 0.00413070154161394 hsa-miR-22-3p AKT2 1.21545661147757 1.61670170137775e-13 -0.0302247278777559 0.77731841275645 mirMAP -0.0946689309918694 0.00202026831084691 hsa-miR-338-3p AKT2 0.453166438193782 0.144583389707558 -0.0302247278777559 0.77731841275645 mirMAP -0.0558618567359771 0.000709778409691823 hsa-miR-365a-3p AKT2 -0.0388985816963467 0.859114494267351 -0.0302247278777559 0.77731841275645 mirMAP -0.0706931963599922 0.00273734855865171 hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 hsa-miR-3065-5p PPP3CB 2.74629919868982 1.86846589298284e-08 -1.03671584843429 6.12489584217064e-15 mirMAP -0.0620114432668879 0.000138854612360636 hsa-miR-7-1-3p PPP3CB 1.84950311431067 1.25300363397654e-13 -1.03671584843429 6.12489584217064e-15 mirMAP -0.170702158890249 1.5272735318301e-11 hsa-miR-16-2-3p PRKAR1A 2.31623086727196 4.29838149388188e-20 -0.494707246064478 1.09832496534671e-05 mirMAP -0.0918148205391201 8.29785718068452e-06 hsa-miR-30b-5p PRKAR1A 0.800822374912712 0.000133601914525413 -0.494707246064478 1.09832496534671e-05 mirMAP -0.109738357042516 2.35678449980593e-05 hsa-miR-30c-5p PRKAR1A 0.778774633108 0.000285599212429136 -0.494707246064478 1.09832496534671e-05 mirMAP -0.117852671733036 3.18561702613009e-06 hsa-miR-32-3p PRKAR1A 2.02436999565685 5.94091197945307e-09 -0.494707246064478 1.09832496534671e-05 mirMAP -0.0642208683396288 0.000253119593681182 hsa-miR-186-5p PRKAR1A 1.47445398888668 3.0781726595413e-15 -0.494707246064478 1.09832496534671e-05 mirMAP -0.158555937704806 1.81385800124173e-08 hsa-miR-30e-5p PRKAR1A 1.23904909539663 1.35561917122157e-09 -0.494707246064478 1.09832496534671e-05 mirMAP -0.13563514438677 2.13471830667205e-07 hsa-miR-664a-3p PRKAR1A 0.634721925861133 0.00520070178640421 -0.494707246064478 1.09832496534671e-05 mirMAP -0.0572206408467312 0.0179548287678573 hsa-miR-148a-3p PRKAR2A 1.26728238710376 2.52325607402829e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.173503602499007 0.00144323618557555 hsa-miR-148b-3p PRKAR2A 1.97815018171325 6.07715327281595e-26 -0.958058230501873 0.00166358416501506 mirMAP -0.308772207570419 3.36765416449186e-05 hsa-miR-182-5p PRKAR2A 3.53923166221814 5.07781258121574e-21 -0.958058230501873 0.00166358416501506 mirMAP -0.15304190547009 3.93441644995187e-05 hsa-miR-21-5p PRKAR2A 2.73773305747971 1.38864982139576e-43 -0.958058230501873 0.00166358416501506 mirMAP -0.260585514930639 0.000114596506486694 hsa-miR-25-3p PRKAR2A 1.36472605225697 4.83790725935681e-11 -0.958058230501873 0.00166358416501506 mirMAP -0.199840197599522 0.00445130930358387 hsa-miR-26b-5p PRKAR2A 0.885393662798425 3.2116297961629e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.352489387774103 5.1180473461065e-06 hsa-miR-29a-5p PRKAR2A 1.46749674755271 3.34605004270294e-07 -0.958058230501873 0.00166358416501506 mirMAP -0.171509666685872 0.00142484408765363 hsa-miR-320a PRKAR2A 0.438165828017084 0.0390159073347133 -0.958058230501873 0.00166358416501506 mirMAP -0.364222003224594 1.57087202982753e-07 hsa-miR-320b PRKAR2A 1.55692969039548 1.41071034251915e-08 -0.958058230501873 0.00166358416501506 mirMAP -0.199908717374264 0.00016060086703581 hsa-miR-32-5p PRKAR2A 2.34056473219422 6.24134585974322e-20 -0.958058230501873 0.00166358416501506 mirMAP -0.164785528189658 0.00290913268502593 hsa-miR-3607-3p PRKAR2A 2.68532138541128 5.66716351955047e-14 -0.958058230501873 0.00166358416501506 mirMAP -0.168318445015138 4.10453820829504e-05 hsa-miR-3913-5p PRKAR2A 2.44353493655328 8.95279496632448e-15 -0.958058230501873 0.00166358416501506 mirMAP -0.201996350129065 1.42424912878332e-05 hsa-miR-582-3p PRKAR2A 0.00876844181512659 0.977126166214707 -0.958058230501873 0.00166358416501506 mirMAP -0.125770824276989 0.00964624611957725 hsa-miR-590-5p PRKAR2A 3.18300989862077 2.06813568597893e-26 -0.958058230501873 0.00166358416501506 mirMAP -0.194427880221685 4.28778026268334e-05 hsa-miR-708-3p PRKAR2A 2.80907765282502 3.07460722669281e-14 -0.958058230501873 0.00166358416501506 mirMAP -0.0988599692421547 0.0107953259678287 hsa-miR-7-1-3p PRKAR2A 1.84950311431067 1.25300363397654e-13 -0.958058230501873 0.00166358416501506 mirMAP -0.173196690749086 0.00271404934063376 hsa-miR-92a-3p PRKAR2A 2.06460102658973 1.44784291084757e-19 -0.958058230501873 0.00166358416501506 mirMAP -0.212779014359801 0.000625507145973245 hsa-miR-944 PRKAR2A 2.91186649218281 1.31574753528144e-06 -0.958058230501873 0.00166358416501506 mirMAP -0.0668463473645314 0.00761124962860001 hsa-miR-106a-5p PRKAR2A 2.48882002962836 1.99757727374521e-12 -0.958058230501873 0.00166358416501506 mirMAP -0.0829242674706705 0.0421312002706923 hsa-miR-106b-5p PRKAR2A 2.46782146831112 1.36171495805632e-23 -0.958058230501873 0.00166358416501506 mirMAP -0.242653924640786 1.85440556319997e-05 hsa-miR-17-5p PRKAR2A 3.2710598467455 9.93128340539455e-27 -0.958058230501873 0.00166358416501506 mirMAP -0.213035467903906 2.30881349927684e-06 hsa-miR-20a-5p PRKAR2A 3.15577933619191 4.19753346442454e-25 -0.958058230501873 0.00166358416501506 mirMAP -0.262949466382429 5.45103485479054e-09 hsa-miR-20b-5p PRKAR2A 2.07706563022469 1.10107236083433e-05 -0.958058230501873 0.00166358416501506 mirMAP -0.0910726538757002 0.00325446366334549 hsa-miR-17-3p IL1R1 2.2704817679209 1.1667437320211e-22 -0.754392858754991 0.00819157634786962 mirMAP -0.457437413596706 7.7813507528449e-17 hsa-miR-181b-5p IL1R1 2.49307679431293 3.92829250217627e-20 -0.754392858754991 0.00819157634786962 mirMAP -0.144149390460215 0.00312034364681948 hsa-miR-186-5p IL1R1 1.47445398888668 3.0781726595413e-15 -0.754392858754991 0.00819157634786962 mirMAP -0.413980327390447 6.22085295917803e-09 hsa-miR-26b-5p IL1R1 0.885393662798425 3.2116297961629e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.287058738544535 7.46900640431975e-05 hsa-miR-30d-3p IL1R1 0.977747550180601 4.3048212205381e-05 -0.754392858754991 0.00819157634786962 mirMAP -0.207730148083987 0.000312780009684164 hsa-miR-335-3p IL1R1 3.08791651139852 5.31309869723517e-12 -0.754392858754991 0.00819157634786962 mirMAP -0.128248188751599 1.75690264294768e-05 hsa-miR-944 IL1R1 2.91186649218281 1.31574753528144e-06 -0.754392858754991 0.00819157634786962 mirMAP -0.118403143401936 3.14768683036805e-07 hsa-miR-130b-5p IL1R1 2.9963110846538 1.98883029416455e-18 -0.754392858754991 0.00819157634786962 mirMAP -0.265810866002561 8.60645196440847e-12 hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 hsa-miR-3065-5p PIK3R3 2.74629919868982 1.86846589298284e-08 -0.627704444396048 0.00578594022892978 mirMAP;miRNATAP -0.0640162238588998 0.0187365945874149 hsa-miR-708-3p PIK3R3 2.80907765282502 3.07460722669281e-14 -0.627704444396048 0.00578594022892978 mirMAP -0.0877076522501003 0.00235951475615563 hsa-miR-139-5p APAF1 -1.52606598644743 1.20474151350665e-08 0.392057672964835 0.00374480729317335 mirMAP -0.0516641324392396 0.0322646900265725 hsa-miR-33a-3p TNFSF10 1.72765312072219 1.51784443453521e-07 0.62151336306871 0.110711377947693 mirMAP -0.24294878555277 8.65859088331346e-05 hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 hsa-miR-3607-3p PIK3CA 2.68532138541128 5.66716351955047e-14 -0.151828236462886 0.321284398928338 mirMAP -0.0603656992151189 0.0033109153473362 hsa-miR-495-3p PIK3CA -0.0847115949846082 0.763475496144456 -0.151828236462886 0.321284398928338 mirMAP -0.0900920798451878 0.000621003495143061 hsa-miR-501-5p PIK3CA 1.93654809410041 1.3779381780759e-10 -0.151828236462886 0.321284398928338 mirMAP -0.0829968054795475 0.000748206365176205 hsa-miR-125b-2-3p CASP9 -1.83175829351767 2.94917958974528e-05 -0.446359927280876 0.00400976702291555 mirMAP -0.0673957165633185 9.18982536656168e-05 hsa-miR-199a-3p CASP9 0.640600337515787 0.0380326905134914 -0.446359927280876 0.00400976702291555 mirMAP -0.146082132838509 1.00313136531724e-09 hsa-miR-199b-3p CASP9 0.643923492750702 0.0371742251925406 -0.446359927280876 0.00400976702291555 mirMAP -0.146136089499986 9.60609442207656e-10 hsa-miR-222-5p CASP9 1.25632771414778 0.000138653440511922 -0.446359927280876 0.00400976702291555 mirMAP -0.126831808191525 1.31064720813193e-08 hsa-miR-424-5p CASP9 1.61930224569578 1.89642549274994e-10 -0.446359927280876 0.00400976702291555 mirMAP -0.0659642623796356 0.0232208202467714 hsa-miR-374a-3p RIPK1 0.533309330504947 0.00192918429705142 -0.323726292412104 0.00484264630910019 mirMAP -0.064520223021078 0.048372863326544 hsa-miR-186-5p PPP3CA 1.47445398888668 3.0781726595413e-15 -0.281979431665802 0.0843014975757299 mirMAP -0.185694598107894 5.66511837519636e-06 hsa-miR-3065-5p PPP3CA 2.74629919868982 1.86846589298284e-08 -0.281979431665802 0.0843014975757299 mirMAP;miRNATAP -0.0509505793517531 0.00882650698743328 hsa-miR-664a-3p PPP3CA 0.634721925861133 0.00520070178640421 -0.281979431665802 0.0843014975757299 mirMAP -0.150747155909677 1.3336356409105e-05 hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 hsa-miR-365a-3p AKT1 -0.0388985816963467 0.859114494267351 0.128947014292221 0.203881780391473 mirMAP -0.0728473542292503 0.00113891312915844 hsa-miR-374a-5p PRKACB 0.484615721953736 0.0042981729815149 -1.11910356116881 7.24897707751757e-07 mirMAP -0.166638670031419 0.0116689154239509 hsa-miR-126-5p PRKACB 0.895338176458417 2.33372756450713e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.171245788041164 0.00102349617124601 hsa-miR-16-2-3p PRKACB 2.31623086727196 4.29838149388188e-20 -1.11910356116881 7.24897707751757e-07 mirMAP -0.211513116774948 3.56654687944943e-07 hsa-miR-30d-3p PRKACB 0.977747550180601 4.3048212205381e-05 -1.11910356116881 7.24897707751757e-07 mirMAP -0.230639716646997 4.57613056559806e-07 hsa-miR-32-3p PRKACB 2.02436999565685 5.94091197945307e-09 -1.11910356116881 7.24897707751757e-07 mirMAP;miRNATAP -0.100714992594509 0.00471640544853458 hsa-miR-450b-5p PRKACB 1.69244418548325 1.68064054148881e-10 -1.11910356116881 7.24897707751757e-07 mirMAP -0.0841826254341061 0.0403611944801111 hsa-miR-708-3p PRKACB 2.80907765282502 3.07460722669281e-14 -1.11910356116881 7.24897707751757e-07 mirMAP -0.107628106192083 0.000190951072862047 hsa-miR-7-1-3p PRKACB 1.84950311431067 1.25300363397654e-13 -1.11910356116881 7.24897707751757e-07 mirMAP -0.160819398581311 0.000186176032630634 hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 hsa-miR-200c-3p PIK3R1 3.50132673580082 2.42716349086937e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.0549402666456561 0.0342380862176309 hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 hsa-miR-32-3p PIK3R1 2.02436999565685 5.94091197945307e-09 -1.16357283690918 1.63774086027679e-06 mirMAP -0.0809069992032009 0.0349095308992423 hsa-miR-335-3p PIK3R1 3.08791651139852 5.31309869723517e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.076442193839567 0.00303273833312375 hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 hsa-miR-429 PIK3R1 4.48815175680773 2.44117492218206e-17 -1.16357283690918 1.63774086027679e-06 mirMAP;miRNATAP -0.0554753866913029 0.00987336466542612 hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 hsa-miR-495-3p PIK3R1 -0.0847115949846082 0.763475496144456 -1.16357283690918 1.63774086027679e-06 mirMAP -0.0960899695814073 0.0239315868381009 hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 hsa-miR-16-1-3p ENDOD1 2.56983217111073 3.02262181237943e-20 -0.331902287589133 0.146465367778401 mirMAP -0.176726234672374 4.76351781243037e-06 hsa-miR-19a-3p ENDOD1 3.42309334186656 3.02671914353412e-28 -0.331902287589133 0.146465367778401 mirMAP -0.138604025645659 2.7728778889914e-05 hsa-miR-19b-3p ENDOD1 2.49529833021187 1.57028265846699e-23 -0.331902287589133 0.146465367778401 mirMAP -0.189604053563397 5.4551020074105e-06 hsa-miR-26b-3p ENDOD1 2.18464160365372 2.11543189388328e-18 -0.331902287589133 0.146465367778401 mirMAP -0.136637022611884 0.00131032309806543 hsa-miR-186-5p ATM 1.47445398888668 3.0781726595413e-15 -0.694304374354523 1.11905560067279e-05 mirMAP -0.162572896698222 4.94897138455636e-05 hsa-miR-21-5p ATM 2.73773305747971 1.38864982139576e-43 -0.694304374354523 1.11905560067279e-05 mirMAP -0.176310423151013 4.47713388674926e-07 hsa-miR-29a-5p ATM 1.46749674755271 3.34605004270294e-07 -0.694304374354523 1.11905560067279e-05 mirMAP -0.090317853164084 0.0012436877980901 hsa-miR-30c-5p ATM 0.778774633108 0.000285599212429136 -0.694304374354523 1.11905560067279e-05 mirMAP -0.107066600206639 0.00288450607513559 hsa-miR-335-3p ATM 3.08791651139852 5.31309869723517e-12 -0.694304374354523 1.11905560067279e-05 mirMAP -0.0514483956990691 0.00208293513833482 hsa-miR-3607-3p ATM 2.68532138541128 5.66716351955047e-14 -0.694304374354523 1.11905560067279e-05 mirMAP -0.0786334626790037 0.00023741025400724 hsa-miR-500a-5p ATM 1.72110365584658 3.0807246212659e-10 -0.694304374354523 1.11905560067279e-05 mirMAP -0.0999939776574252 0.000291244594703456 hsa-miR-576-5p ATM 2.20467023993664 3.4053475193793e-19 -0.694304374354523 1.11905560067279e-05 mirMAP -0.17622953753732 2.51071157737834e-09 hsa-miR-590-5p ATM 3.18300989862077 2.06813568597893e-26 -0.694304374354523 1.11905560067279e-05 mirMAP -0.155698076358082 1.697182104602e-10 hsa-miR-33a-3p CAPN2 1.72765312072219 1.51784443453521e-07 -0.422341253524924 0.0913287396375096 mirMAP -0.270141056401029 4.05112944673904e-12 hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 hsa-miR-16-1-3p BCL2 2.56983217111073 3.02262181237943e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.3266254366235 1.09255462667175e-11 23867991;18931683 miR-15a and miR-16-1 are important tumor suppressors through modulating B cell lymphoma 2 Bcl-2 Cyclin D1 D2 and others;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2 ; lung cancer;prostate cancer hsa-miR-186-5p BCL2 1.47445398888668 3.0781726595413e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.423453081728092 3.67590705887486e-09 hsa-miR-126-5p BCL2 0.895338176458417 2.33372756450713e-05 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136813897862068 0.0382651228386025 hsa-miR-130b-5p BCL2 2.9963110846538 1.98883029416455e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.257233532043175 6.21636254360678e-11 hsa-miR-15b-3p BCL2 2.33847028227712 4.29662877950836e-19 -2.02088083891464 5.5300725103229e-13 mirMAP -0.323477257690888 1.09586549927814e-10 18449891;18449891;18449891 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells;The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein;Enforced mir-15b or miR-16 expression reduced Bcl-2 protein level and the luciferase activity of a BCL2 3' untranslated region-based reporter construct in SGC7901/VCR cells suggesting that BCL2 is a direct target of miR-15b and miR-16 drug resistance;;; stomach cancer;stomach cancer;stomach cancer hsa-miR-16-2-3p BCL2 2.31623086727196 4.29838149388188e-20 -2.02088083891464 5.5300725103229e-13 mirMAP -0.283819463467791 5.74174499512362e-08 hsa-miR-200a-5p BCL2 3.86316681673704 1.81076942093171e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.15999187261028 4.28833785580744e-09 hsa-miR-200b-5p BCL2 2.54484902707822 1.59240467582976e-06 -2.02088083891464 5.5300725103229e-13 mirMAP -0.136099351840362 2.8230250510626e-06 hsa-miR-20a-3p BCL2 2.92621109947706 2.49504904635375e-17 -2.02088083891464 5.5300725103229e-13 mirMAP -0.210564396671593 8.96802878439544e-08 hsa-miR-224-3p BCL2 1.87536386559317 6.15140969394846e-05 -2.02088083891464 5.5300725103229e-13 mirMAP -0.0990023017290901 0.00135017541164802 24796455;22989374;22989374 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01;The high-ranking genes CDC42 CDH1 PAK2 BCL-2 and MAPK1 were confirmed as important targets of miR-224 and involvement in hepatocarcinogenesis;Overexpression of miR-224 significantly in Hek293 and Huh7 cells altered the expression levels of CDC42 CDH1 PAK2 and BCL-2 at both mRNA and protein levels ;tumorigenesis;; stomach cancer;liver cancer;liver cancer hsa-miR-224-5p BCL2 2.94107125335675 5.72194099515157e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.119749067233376 1.76067406110872e-06 24796455;22989374;22989374 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01;The high-ranking genes CDC42 CDH1 PAK2 BCL-2 and MAPK1 were confirmed as important targets of miR-224 and involvement in hepatocarcinogenesis;Overexpression of miR-224 significantly in Hek293 and Huh7 cells altered the expression levels of CDC42 CDH1 PAK2 and BCL-2 at both mRNA and protein levels ;tumorigenesis;; stomach cancer;liver cancer;liver cancer hsa-miR-29a-5p BCL2 1.46749674755271 3.34605004270294e-07 -2.02088083891464 5.5300725103229e-13 mirMAP -0.213517369621975 2.31345511002058e-05 hsa-miR-3065-5p BCL2 2.74629919868982 1.86846589298284e-08 -2.02088083891464 5.5300725103229e-13 mirMAP -0.154823847891893 5.79242637365127e-06 hsa-miR-32-3p BCL2 2.02436999565685 5.94091197945307e-09 -2.02088083891464 5.5300725103229e-13 mirMAP -0.20244441600453 5.71853892832186e-06 hsa-miR-335-3p BCL2 3.08791651139852 5.31309869723517e-12 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104382164677445 0.000555265264147089 23708561 B-cell CLL/lymphoma 2 like 2 Bcl-w or BCL2L2 a pro-survival member of the Bcl-2 protein family was identified as a potential target of miR-335 according to the results of bioinformatic analysis and the expression of Bcl-w and its effector matrix metalloproteinase-2 MMP‑2 was downregulated after transfection with miR-335 mimics worse survival; ovarian cancer hsa-miR-33a-5p BCL2 3.79671563098419 1.15966309820345e-18 -2.02088083891464 5.5300725103229e-13 mirMAP -0.197338268783918 2.87180137117656e-09 hsa-miR-450b-5p BCL2 1.69244418548325 1.68064054148881e-10 -2.02088083891464 5.5300725103229e-13 mirMAP -0.195491457721654 0.000146490668566645 hsa-miR-452-5p BCL2 1.37180058737183 0.00171494843537772 -2.02088083891464 5.5300725103229e-13 mirMAP -0.104092924779063 0.00100591652628657 hsa-miR-455-5p BCL2 2.2582442061694 1.43472128037398e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.296135324171891 8.75003372187937e-12 hsa-miR-629-5p BCL2 2.10182419359635 1.51788571125757e-15 -2.02088083891464 5.5300725103229e-13 mirMAP -0.237720791875816 2.9555469743804e-06 hsa-miR-664a-5p BCL2 0.505019913598436 0.032933350691651 -2.02088083891464 5.5300725103229e-13 mirMAP -0.133435367665978 0.0249936816629116 hsa-miR-7-1-3p BCL2 1.84950311431067 1.25300363397654e-13 -2.02088083891464 5.5300725103229e-13 mirMAP -0.256930851687325 1.96074632615661e-06 hsa-miR-186-5p TNFRSF10D 1.47445398888668 3.0781726595413e-15 -1.21952127016643 0.000173029902186277 mirMAP -0.17896857256799 0.0307715580575795 hsa-miR-186-5p IL1RAP 1.47445398888668 3.0781726595413e-15 0.687376288697117 0.0561773808581464 mirMAP -0.248147291056268 0.0064761570270495 hsa-miR-664a-3p IL1RAP 0.634721925861133 0.00520070178640421 0.687376288697117 0.0561773808581464 mirMAP -0.367234968888842 1.50065370650936e-06 hsa-miR-335-3p IL1RAP 3.08791651139852 5.31309869723517e-12 0.687376288697117 0.0561773808581464 mirMAP -0.116498433237795 0.00206868835534839 hsa-miR-493-5p IRAK4 0.847772103665986 0.00528678068747754 0.189766326709953 0.138288179984644 mirMAP -0.0531323434981004 0.00899858727393343 hsa-miR-20a-3p PPP3CB 2.92621109947706 2.49504904635375e-17 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.113868623377048 9.37084199962394e-10 hsa-miR-32-5p PRKAR2B 2.34056473219422 6.24134585974322e-20 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.276859835292248 5.01298329302752e-05 hsa-miR-576-5p CSF2RB 2.20467023993664 3.4053475193793e-19 -0.739086291347396 0.0696045958228138 miRNATAP -0.289248506739264 0.000161113961006424 hsa-miR-96-5p PRKACB 4.89433085814374 1.92000659886961e-31 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.144257226112366 5.04306410867738e-09 hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 hsa-miR-20b-5p PPP3CA 2.07706563022469 1.10107236083433e-05 -0.281979431665802 0.0843014975757299 miRNATAP -0.113387749946454 1.85473104688059e-12 hsa-miR-106b-5p PPP3CA 2.46782146831112 1.36171495805632e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.184105953911301 6.84398280050895e-10 hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 hsa-let-7g-5p PPP3CA 1.20061455355116 1.50237505511483e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.256650979931267 1.4045207283454e-08 hsa-miR-106a-5p PPP3CA 2.48882002962836 1.99757727374521e-12 -0.281979431665802 0.0843014975757299 miRNATAP -0.11191172835948 1.79556273427309e-07 hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 hsa-miR-23b-3p FAS -0.251132426825047 0.150200321210792 -0.893121037137088 0.00675655818216232 miRNATAP -0.391116610184141 2.37246599324584e-05 hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 hsa-miR-93-5p PPP3CA 3.03961860136032 1.11672209617395e-24 -0.281979431665802 0.0843014975757299 miRNATAP -0.156066415468858 2.44288871078656e-10 hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 hsa-miR-18a-5p PRKACB 3.78535678765353 3.72446596213886e-26 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.170312158994311 1.8268780409686e-08 hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 hsa-miR-101-3p PPP3R1 0.522819989585461 0.00375627731618038 -0.0284423401171923 0.760566460331176 miRNATAP -0.130896280595902 1.18496266678438e-07 hsa-miR-24-3p IL1R1 0.99989036772428 1.35595013650376e-07 -0.754392858754991 0.00819157634786962 miRNATAP -0.329790317110319 4.8735388331152e-06 hsa-miR-3065-3p PPP3CA 2.16221780121195 9.65525739884541e-09 -0.281979431665802 0.0843014975757299 miRNATAP -0.0625562456316198 0.00230586582946532 hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 hsa-miR-324-3p TRADD 2.08739139768981 3.11885987067952e-13 0.654523627495593 9.31374791447117e-05 miRNATAP -0.107791208741327 9.21494516260199e-05 hsa-miR-592 CASP10 1.51765968871077 0.000636335248013204 0.0928615128292813 0.717578504954206 miRNATAP -0.0607280316017113 0.0319774348592027 hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 hsa-miR-34a-5p PRKACB 1.9016323452565 1.43092834643601e-14 -1.11910356116881 7.24897707751757e-07 miRNATAP -0.238915288481547 2.59419071561778e-08 hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 hsa-miR-145-5p AIFM1 -1.55259331973517 9.97889123247165e-07 0.303056224316474 0.00499225344172376 miRNATAP -0.0514336170590221 0.00148792684291437 hsa-miR-30d-5p PPP3CA 0.675423997639582 0.00270618816039773 -0.281979431665802 0.0843014975757299 miRNATAP -0.142883121139453 4.34068465949306e-05 hsa-miR-30d-5p PPP3CB 0.675423997639582 0.00270618816039773 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.128345099197797 1.20380214861929e-05 hsa-miR-17-5p PPP3CA 3.2710598467455 9.93128340539455e-27 -0.281979431665802 0.0843014975757299 miRNATAP -0.0933241886409001 0.000109538547214252 hsa-miR-582-5p PRKAR2A 0.609226359812689 0.032988717891497 -0.958058230501873 0.00166358416501506 miRNATAP -0.204926721580595 7.24251105901293e-05 hsa-miR-200c-3p PRKAR2B 3.50132673580082 2.42716349086937e-15 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.267488379876048 7.71967366135021e-12 hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 hsa-miR-3065-5p PRKAR2B 2.74629919868982 1.86846589298284e-08 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.11341056331334 0.0122444126943186 hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 hsa-miR-20a-5p PPP3CA 3.15577933619191 4.19753346442454e-25 -0.281979431665802 0.0843014975757299 miRNATAP -0.109419648077418 6.17460161232474e-06 hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 hsa-miR-429 TNF 4.48815175680773 2.44117492218206e-17 0.168287325738871 0.711715304997615 miRNATAP -0.169293563460319 1.87983425787946e-05 hsa-miR-429 MAP3K14 4.48815175680773 2.44117492218206e-17 -0.929542138683687 1.31735308419243e-05 miRNATAP -0.149133359352813 2.41419963094442e-16 hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 hsa-miR-15b-5p PPP3CB 1.57112623124278 9.14247846750597e-13 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.245380830384666 5.15260568991425e-18 hsa-miR-342-5p PRKAR2A 1.74634624752902 3.89286511372155e-11 -0.958058230501873 0.00166358416501506 miRNATAP -0.245147904548481 7.00242952332571e-06 hsa-let-7f-5p PPP3CA 0.495648727272215 0.00355972741198794 -0.281979431665802 0.0843014975757299 miRNATAP -0.145174821876866 0.00196996187493329 hsa-miR-340-5p NFKB1 0.30282999308409 0.157744789519131 -0.64818153460532 4.948433163113e-05 miRNATAP -0.0744624584971565 0.0421797344974554 hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 hsa-miR-369-3p IKBKB 0.946781510019564 0.00134850306966842 -0.00227190214342876 0.988714147115007 miRNATAP -0.0981847866010809 0.00016908054674169 hsa-miR-130a-3p PIK3CB 2.02021855058359 1.26427102520415e-11 0.0812060217229131 0.586462041835271 miRNATAP -0.0548647878304546 0.0199911586887662 hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 hsa-miR-497-5p PPP3CB 0.0257087130056286 0.918145413833358 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.0865810330364637 0.00114071612935126 hsa-miR-182-5p PRKAR1A 3.53923166221814 5.07781258121574e-21 -0.494707246064478 1.09832496534671e-05 miRNATAP -0.0567111816542074 3.66485110433976e-05 hsa-miR-182-5p PIK3R1 3.53923166221814 5.07781258121574e-21 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.0776388342304529 0.00977683704481019 hsa-miR-30c-5p PPP3CA 0.778774633108 0.000285599212429136 -0.281979431665802 0.0843014975757299 miRNATAP -0.212081199369466 4.85681407465908e-09 hsa-miR-30c-5p PPP3CB 0.778774633108 0.000285599212429136 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.165551300673001 5.92944884537219e-08 hsa-miR-92a-3p PRKAR2B 2.06460102658973 1.44784291084757e-19 -2.6424142214808 7.30155345842383e-13 miRNATAP -0.464704311408613 9.32577627372663e-10 hsa-miR-582-3p PIK3CA 0.00876844181512659 0.977126166214707 -0.151828236462886 0.321284398928338 miRNATAP -0.0518299165216251 0.0325574956347829 hsa-miR-15a-5p PPP3CB 2.34669284378787 1.69544424500258e-23 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.188034579267018 6.2219880807044e-13 hsa-miR-125b-5p AIFM1 -1.16462950151259 0.000288900271798384 0.303056224316474 0.00499225344172376 miRNATAP -0.087393754623017 3.8935672467902e-08 hsa-miR-93-3p PPP3CA 2.85383869771942 5.64481766902125e-23 -0.281979431665802 0.0843014975757299 miRNATAP -0.152353546507485 2.15079066361371e-09 hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 hsa-miR-424-5p PPP3CB 1.61930224569578 1.89642549274994e-10 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.0982586568405929 0.000116297130158393 hsa-let-7e-5p FASLG 0.860104282510173 6.04758298373779e-05 -0.196180452389551 0.711804379159628 miRNATAP -0.681095573446369 7.73237301751494e-09 hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 hsa-miR-320b PIK3R1 1.55692969039548 1.41071034251915e-08 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.0967011095672297 0.0236391980598286 hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 hsa-miR-16-5p PPP3CB 1.75824877145857 1.68592440033108e-16 -1.03671584843429 6.12489584217064e-15 miRNATAP -0.219222038672189 7.36535140884335e-14