miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-143-3p ABHD14A -0.0402404826858778 0.987317207979986 -0.0171976553051958 0.971451087896474 MirTarget -0.116551942979117 0.0396903773744026 NA NA NA hsa-miR-143-3p ABLIM1 -0.0402404826858778 0.987317207979986 -0.177307864932784 0.868809257942419 mirMAP -0.136882845133566 0.0071641252313971 NA NA NA hsa-miR-125b-5p ACPP 0.00744496603712985 0.994576506820994 -0.425264789682876 0.340385721673441 MirTarget -0.235266893915635 0.0170006329724724 NA NA NA hsa-miR-1275 ACSS3 -0.092958576443477 0.78712696322568 0.281788730007319 0.500722395000959 MirTarget -0.240254269538454 0.0066566402965975 NA NA NA hsa-miR-1275 ADAM11 -0.092958576443477 0.78712696322568 0.110344082992695 0.803693858817661 MirTarget -0.245080481896314 0.000218736347851871 NA NA NA hsa-miR-222-3p ADAM11 0.067264556454159 0.934147523407911 0.110344082992695 0.803693858817661 miRNATAP -0.325328930011904 0.00543484176528661 NA NA NA hsa-miR-320c ADAM12 -0.634817265516566 0.0229406911033521 0.33068108521269 0.624533610443056 mirMAP -0.216608053601732 0.037054417937874 NA NA NA hsa-miR-320c ADAM19 -0.634817265516566 0.0229406911033521 0.139346254867426 0.860386763531288 mirMAP -0.214213567264534 0.000327333427864858 NA NA NA hsa-miR-222-3p ADAM22 0.067264556454159 0.934147523407911 -0.435362913749347 0.162176348821986 MirTarget;miRNATAP -0.403907603745206 0.000398698345592792 NA NA NA hsa-miR-320c ADAMTS14 -0.634817265516566 0.0229406911033521 0.144575055689755 0.761404432134999 miRanda -0.187043836817544 0.000422036878283056 NA NA NA hsa-miR-10a-5p ADAMTS2 -0.103091346403293 0.963361104257071 0.146332016142478 0.818814023361637 MirTarget -0.592970218244656 9.98539935145127e-07 NA NA NA hsa-miR-320c ADAMTS3 -0.634817265516566 0.0229406911033521 -0.154024576690568 0.577719174199327 mirMAP -0.153376032902054 0.0199724183227472 NA NA NA hsa-miR-222-3p ADAMTS6 0.067264556454159 0.934147523407911 0.0183597197245207 0.94872966545501 MirTarget -0.326495547564669 0.000333118928556693 NA NA NA hsa-miR-320c ADAMTSL1 -0.634817265516566 0.0229406911033521 -0.220442948122527 0.553296536801052 miRanda;mirMAP -0.210110914273431 0.00992838599794075 NA NA NA hsa-miR-1275 ADAP2 -0.092958576443477 0.78712696322568 0.280710086314909 0.475950168329298 MirTarget -0.183848310468566 2.79689566030187e-06 NA NA NA hsa-miR-1275 ADARB1 -0.092958576443477 0.78712696322568 -0.0322745559781419 0.95214549327251 MirTarget -0.119324730325297 0.000125347153540099 NA NA NA hsa-miR-10a-5p ADCY1 -0.103091346403293 0.963361104257071 0.375845505460799 0.253712161593449 mirMAP -0.43931745395192 8.42353059583631e-06 NA NA NA hsa-miR-1275 ADCY2 -0.092958576443477 0.78712696322568 0.0918631962110212 0.803116293992558 MirTarget -0.204520990872794 0.00727689664094732 NA NA NA hsa-miR-320c ADCY5 -0.634817265516566 0.0229406911033521 -0.548362913180624 0.233400631729444 mirMAP -0.263480309461236 0.035599000661809 NA NA NA hsa-miR-10a-5p ADCY9 -0.103091346403293 0.963361104257071 -0.210387081008281 0.755529107296372 miRNAWalker2_validate -0.124174924947978 0.00431879645615545 NA NA NA hsa-miR-320c ADCYAP1 -0.634817265516566 0.0229406911033521 0.13067445653388 0.796624287577034 PITA;miRanda;miRNATAP -0.360130396072429 0.00736354485468102 NA NA NA hsa-miR-143-3p ADD3 -0.0402404826858778 0.987317207979986 -0.0577573467719938 0.95579574331121 MirTarget;miRNATAP -0.213858532701667 9.37611144512949e-06 NA NA NA hsa-miR-125b-5p ADM 0.00744496603712985 0.994576506820994 0.222732557354072 0.728785853443004 miRNAWalker2_validate -0.18559225215426 0.00249266230956056 NA NA NA hsa-miR-320c ADRA1D -0.634817265516566 0.0229406911033521 0.0488112943956676 0.912375865327699 miRanda -0.299082135931932 0.000216951531332713 NA NA NA hsa-miR-1275 ADRB2 -0.092958576443477 0.78712696322568 -0.00680707237127476 0.984885889943271 MirTarget -0.250822439823909 0.000229882514572114 NA NA NA hsa-miR-1275 AFF3 -0.092958576443477 0.78712696322568 -0.49957426373599 0.157676889560121 MirTarget -0.215538203210013 0.00413880330498394 NA NA NA hsa-miR-10a-5p AGAP2 -0.103091346403293 0.963361104257071 -0.042662119502531 0.918898321297125 mirMAP -0.237360034036566 0.0315120464007124 NA NA NA hsa-miR-1275 AGAP2 -0.092958576443477 0.78712696322568 -0.042662119502531 0.918898321297125 MirTarget;miRNATAP -0.209723182745408 0.00368710906177199 NA NA NA hsa-miR-1275 AKT3 -0.092958576443477 0.78712696322568 0.0571686886013749 0.909084961269096 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-320c AKT3 -0.634817265516566 0.0229406911033521 0.0571686886013749 0.909084961269096 PITA;miRanda;miRNATAP -0.168706913972951 0.0152504739210101 NA NA NA hsa-miR-10a-5p ALDH1A2 -0.103091346403293 0.963361104257071 0.558750258816193 0.375608943251491 miRNAWalker2_validate -0.489423620932701 0.0145877577287253 NA NA NA hsa-miR-100-5p ALG3 -0.0835426508859793 0.958163253942357 0.0690157508341498 0.937817936244071 miRNAWalker2_validate -0.11949445912331 3.79616220152443e-06 NA NA NA hsa-miR-1275 AMOTL1 -0.092958576443477 0.78712696322568 -0.111318937781736 0.85689287537907 miRNATAP -0.261289021413562 2.01558831636495e-05 NA NA NA hsa-miR-10a-5p AMPD1 -0.103091346403293 0.963361104257071 0.0253484745010244 0.969509960589717 miRNAWalker2_validate -0.408955735784487 0.00389434804933731 NA NA NA hsa-miR-320c AMPH -0.634817265516566 0.0229406911033521 0.0773622635950866 0.811243129361095 miRanda -0.208277493119542 0.0155561623162018 NA NA NA hsa-miR-222-3p ANGPTL2 0.067264556454159 0.934147523407911 -0.073973929360041 0.92845055758781 MirTarget;miRNATAP -0.585266999545272 8.8442697529783e-09 NA NA NA hsa-miR-10a-5p ANK2 -0.103091346403293 0.963361104257071 0.0352341929135667 0.931659991031595 miRNATAP -0.644049578567742 9.68424993413928e-09 NA NA NA hsa-miR-1275 ANK2 -0.092958576443477 0.78712696322568 0.0352341929135667 0.931659991031595 MirTarget -0.310280367038985 3.61672421263041e-05 NA NA NA hsa-miR-222-3p ANKRD12 0.067264556454159 0.934147523407911 -0.200372294023635 0.770408560417325 MirTarget -0.11292716903344 0.00921465662528038 NA NA NA hsa-miR-10a-5p AOC3 -0.103091346403293 0.963361104257071 -0.066492633748525 0.926791178114505 mirMAP -0.700473924588794 1.19005221064453e-11 NA NA NA hsa-miR-100-5p APEX1 -0.0835426508859793 0.958163253942357 0.0191717697475529 0.985214284656822 miRNAWalker2_validate -0.101015688459472 0.000374998081593544 NA NA NA hsa-miR-1275 APLNR -0.092958576443477 0.78712696322568 0.00540358270943475 0.993262896155234 MirTarget -0.231576489332872 8.57125570639937e-06 NA NA NA hsa-miR-143-3p APPL2 -0.0402404826858778 0.987317207979986 -0.137945563174323 0.866773648709602 MirTarget -0.101712589194532 0.00490734674224444 NA NA NA hsa-miR-222-3p AQP3 0.067264556454159 0.934147523407911 -0.0209093326473377 0.975834078370521 MirTarget -0.489469270061224 0.000443425905780921 NA NA NA hsa-miR-1275 AQP9 -0.092958576443477 0.78712696322568 0.180318845507605 0.731153168462021 MirTarget -0.510963327559928 1.16224970113363e-06 NA NA NA hsa-miR-143-3p ARHGAP26 -0.0402404826858778 0.987317207979986 -0.147900500341228 0.860076627620244 MirTarget -0.142092429066545 0.0019948456658515 NA NA NA hsa-miR-128-3p ARHGEF37 -0.0947822287384579 0.92304267720799 -0.0226986097267923 0.966109876762791 MirTarget -0.412931348673318 1.0479488434775e-06 NA NA NA hsa-miR-192-5p ARHGEF37 0.0697292340294755 0.973773819800855 -0.0226986097267923 0.966109876762791 mirMAP -0.158264249569619 0.00273784499855335 NA NA NA hsa-miR-590-5p ARHGEF37 -0.06413635524473 0.893491421748758 -0.0226986097267923 0.966109876762791 mirMAP -0.170980174234439 0.00371756395017745 NA NA NA hsa-miR-1275 ARL10 -0.092958576443477 0.78712696322568 -0.238827156337434 0.427328810634801 mirMAP -0.155127699890825 0.00833627606957063 NA NA NA hsa-miR-320c ASB5 -0.634817265516566 0.0229406911033521 -0.195059534800569 0.808376238236324 PITA;miRanda -0.268634112127823 0.0305716900968609 NA NA NA hsa-miR-106a-5p ASPA -0.220241577853689 0.671337298786352 -0.302376721471055 0.574610925357617 mirMAP -0.60537672199327 2.13082153190401e-07 NA NA NA hsa-miR-106b-5p ASPA 0.0054863796897946 0.996055976715358 -0.302376721471055 0.574610925357617 mirMAP -0.802729725035264 1.96479328630778e-09 NA NA NA hsa-miR-1304-5p ASPA -0.570070188468564 0.0449885571601232 -0.302376721471055 0.574610925357617 mirMAP -0.296692015350113 0.000774251813851674 NA NA NA hsa-miR-130b-3p ASPA 0.091215161847729 0.880820555539299 -0.302376721471055 0.574610925357617 mirMAP -0.754240096707823 2.72532411891402e-10 NA NA NA hsa-miR-135b-5p ASPA 0.325348463653214 0.6828613269152 -0.302376721471055 0.574610925357617 mirMAP -0.47419291820738 1.56090536564076e-11 NA NA NA hsa-miR-15b-3p ASPA -0.186733581829334 0.780052884104113 -0.302376721471055 0.574610925357617 mirMAP -0.71318125159146 2.74549289042022e-09 NA NA NA hsa-miR-17-5p ASPA 0.0171021356945324 0.989602604642911 -0.302376721471055 0.574610925357617 mirMAP -0.803155955073251 3.71038558630095e-16 NA NA NA hsa-miR-181a-5p ASPA 0.0759650782391361 0.955324432882321 -0.302376721471055 0.574610925357617 mirMAP -0.317593017025534 0.0299638053533636 NA NA NA hsa-miR-181b-5p ASPA 0.0792125712512002 0.94249452124277 -0.302376721471055 0.574610925357617 mirMAP -0.368464287130545 0.00945163309546567 NA NA NA hsa-miR-20a-3p ASPA 0.00457604227091757 0.993349143429143 -0.302376721471055 0.574610925357617 mirMAP -0.603325004528432 2.99973671417735e-14 NA NA NA hsa-miR-20a-5p ASPA 0.0315169008595895 0.979392076246529 -0.302376721471055 0.574610925357617 mirMAP -0.712977740547449 4.86870608259859e-13 NA NA NA hsa-miR-221-3p ASPA 0.0624231240508077 0.954422926091323 -0.302376721471055 0.574610925357617 MirTarget -0.605931676822545 3.66117597752843e-05 NA NA NA hsa-miR-222-3p ASPA 0.067264556454159 0.934147523407911 -0.302376721471055 0.574610925357617 MirTarget -0.713494502707721 3.5068137672647e-08 NA NA NA hsa-miR-224-3p ASPA 0.032422792414993 0.903234770603146 -0.302376721471055 0.574610925357617 mirMAP -0.283492764660728 0.00309814696499166 NA NA NA hsa-miR-23a-3p ASPA -0.0188223454559413 0.990631768418334 -0.302376721471055 0.574610925357617 mirMAP -1.35977608983507 2.59955956869434e-10 NA NA NA hsa-miR-29b-1-5p ASPA -0.119112600454887 0.756639862832814 -0.302376721471055 0.574610925357617 mirMAP -0.563336282676755 6.09865463486736e-12 NA NA NA hsa-miR-301a-3p ASPA -0.0815092824383015 0.81158875796813 -0.302376721471055 0.574610925357617 mirMAP -0.512300539424274 5.82873222972298e-07 NA NA NA hsa-miR-320a ASPA -0.107569150746519 0.931865460967284 -0.302376721471055 0.574610925357617 miRanda -0.337360634216705 0.0188658882868313 NA NA NA hsa-miR-33a-5p ASPA -0.134015615925217 0.85242059599695 -0.302376721471055 0.574610925357617 mirMAP -0.430205162364214 4.35299222935197e-12 NA NA NA hsa-miR-33b-5p ASPA 0.358162605366953 0.30964970499454 -0.302376721471055 0.574610925357617 mirMAP -0.330113089049114 3.21204370004176e-06 NA NA NA hsa-miR-374b-3p ASPA -0.0786253775219115 0.722308239126602 -0.302376721471055 0.574610925357617 mirMAP -0.411002710405379 0.00185565084961501 NA NA NA hsa-miR-450b-5p ASPA 0.148646457362083 0.720518619482493 -0.302376721471055 0.574610925357617 mirMAP -0.281121598794548 0.0253406522140734 NA NA NA hsa-miR-452-5p ASPA -0.0374958705160777 0.968938070649671 -0.302376721471055 0.574610925357617 mirMAP -0.492883748956695 1.6143668225686e-05 NA NA NA hsa-miR-454-3p ASPA -0.157985412385244 0.64170059693314 -0.302376721471055 0.574610925357617 mirMAP -0.856482447374659 6.95644179645299e-10 NA NA NA hsa-miR-590-3p ASPA 0.0829620326684548 0.810708708264937 -0.302376721471055 0.574610925357617 miRanda;mirMAP -0.46166042387255 2.95130420530646e-06 NA NA NA hsa-miR-93-5p ASPA -0.093851027778495 0.955646810234554 -0.302376721471055 0.574610925357617 mirMAP -0.798979375213703 2.14409231867452e-10 NA NA NA hsa-miR-320c ASTN1 -0.634817265516566 0.0229406911033521 0.04872556846151 0.94222096504886 mirMAP -0.290584780430711 0.00810205729030307 NA NA NA hsa-miR-222-3p ATF2 0.067264556454159 0.934147523407911 -0.238906870274294 0.688956438162092 MirTarget -0.148058599020819 2.60269631326679e-05 NA NA NA hsa-miR-143-3p ATG10 -0.0402404826858778 0.987317207979986 0.0584847384094784 0.857050904741201 MirTarget -0.124486607202453 0.00940945360125021 NA NA NA hsa-miR-10a-5p ATP1A2 -0.103091346403293 0.963361104257071 -0.913237647572935 0.107043243459706 miRNAWalker2_validate -0.825671796723852 6.70607301004242e-06 NA NA NA hsa-miR-1275 ATP1B2 -0.092958576443477 0.78712696322568 -0.102399390126504 0.73974277551826 MirTarget;miRNATAP -0.151925277274899 0.0179443722369132 NA NA NA hsa-miR-100-5p ATP1B3 -0.0835426508859793 0.958163253942357 0.158935768784159 0.880530952486846 miRNAWalker2_validate -0.112324885339865 0.000159784039143031 NA NA NA hsa-miR-100-5p ATP5A1 -0.0835426508859793 0.958163253942357 -0.0325200165173758 0.978770683284254 miRNAWalker2_validate -0.162228068543585 1.17530206340407e-06 NA NA NA hsa-miR-125b-5p ATP5B 0.00744496603712985 0.994576506820994 0.08165020227238 0.952288973819375 miRNAWalker2_validate -0.172596816352285 3.45731501245056e-10 NA NA NA hsa-miR-100-5p ATP5L -0.0835426508859793 0.958163253942357 0.148963375722233 0.884345735259172 miRNAWalker2_validate -0.109460393170567 3.85911911816415e-05 NA NA NA hsa-miR-222-3p ATXN1 0.067264556454159 0.934147523407911 -0.0222025191111346 0.975204997749993 miRNATAP -0.235285823738394 1.0056297866099e-07 NA NA NA hsa-miR-125b-5p AURKB 0.00744496603712985 0.994576506820994 0.0329665281433593 0.961160045700285 miRNAWalker2_validate -0.164516855505844 4.47320350322775e-05 NA NA NA hsa-miR-222-3p AUTS2 0.067264556454159 0.934147523407911 -0.330013443016257 0.704293220480612 miRNAWalker2_validate -0.355317316657791 2.91176609861751e-05 NA NA NA hsa-miR-125b-5p B3GNT3 0.00744496603712985 0.994576506820994 0.173706037034948 0.866358123966972 MirTarget -0.12144613071312 0.00103329806768041 NA NA NA hsa-miR-10a-5p B3GNT7 -0.103091346403293 0.963361104257071 -0.130947546187699 0.849106627970764 mirMAP -0.339945458722843 0.0150729819570608 NA NA NA hsa-miR-320c B4GALNT1 -0.634817265516566 0.0229406911033521 0.223951991272813 0.358872605183395 miRanda -0.16067906683121 0.0131014526470619 NA NA NA hsa-miR-10a-5p BACH2 -0.103091346403293 0.963361104257071 -0.353439542393539 0.267269910248685 MirTarget;miRNATAP -0.500198858404336 5.19341551433279e-07 NA NA NA hsa-miR-1275 BACH2 -0.092958576443477 0.78712696322568 -0.353439542393539 0.267269910248685 MirTarget -0.262040899518601 7.55820017547904e-05 NA NA NA hsa-miR-125b-5p BAG4 0.00744496603712985 0.994576506820994 -0.210378130614623 0.60769561462394 MirTarget;miRNATAP -0.134442540001646 0.000558416246229567 NA NA NA hsa-miR-125b-5p BAK1 0.00744496603712985 0.994576506820994 0.217169708405556 0.783008352332554 miRNAWalker2_validate;miRTarBase;miRNATAP -0.197530646972271 1.61009608323949e-08 24643683;27386402;21823019;18056640;23928699;20460378 miR 125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1; Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 was a direct target of miR-125b; Taken together; our data strongly support an important role for miR-125b on conferring TMZ resistance through targeting Bak1 expression;We subsequently evaluated the effect of miR-125b-1 reactivation on the expression and protein levels of BAK1 a target of miR-125b;An in vitro cytotoxicity assay and apoptosis assay using CCK-8 assay and flow cytometry were carried out to detect the effect of miR-125b and Bak1 on cisplatin resistance of cells; Real-time PCR Western blotting and luciferase reporter assay were used to detect whether Bak1 is a target of miR-125b; Moreover Bak1 was a direct target of miR-125b and down-regulation of Bak1 suppressed cisplatin-induced apoptosis and led to an increased resistance to cisplatin; Our study indicates that miR-125b has a significantly promoting effect on chemoresistance of C13* cells and up-regulation of miR-125b expression contributes to cisplatin resistance through suppression of Bak1 expression;In addition transfection of synthetic miR-125b stimulated androgen-independent growth of CaP cells and down-regulated the expression of Bak1;In contrast miR-125b sponge impaired the anti-apoptotic effect of OCT4 along with the upregulated expression of BAK1; Significantly Luciferase assay showed that the activity of the wild-type BAK1 3'-untranslated region reporter was suppressed and this suppression was diminished when the miR-125b response element was mutated or deleted; In addition we observed negative correlation between levels of BAK1 and OCT4 and positive between OCT4 and miR-125b in primary cervical cancers; These findings suggest an undescribed regulatory pathway in cervical cancer by which OCT4 directly induces expression of miR-125b which inhibits its direct target BAK1 leading to suppression of cervical cancer cell apoptosis;Moreover we demonstrated that the pro-apoptotic Bcl-2 antagonist killer 1 Bak1 is a direct target of miR-125b; Restoring Bak1 expression by either miR-125b inhibitor or re-expression of Bak1 in miR-125b-overexpressing cells recovered Taxol sensitivity overcoming miR-125-mediated Taxol resistance; Taken together our data strongly support a central role for miR-125b in conferring Taxol resistance through the suppression of Bak1 expression drug resistance;;drug resistance;;drug resistance;drug resistance glioblastoma;breast cancer;ovarian cancer;prostate cancer;cervical and endocervical cancer;breast cancer hsa-miR-320c BASP1 -0.634817265516566 0.0229406911033521 0.0644652053116834 0.911318862964942 PITA;miRanda -0.149765183171104 0.0331815488539314 NA NA NA hsa-miR-143-3p BBC3 -0.0402404826858778 0.987317207979986 0.0105049747914281 0.986812934835348 miRNATAP -0.122431615510744 0.0368428704987776 NA NA NA hsa-miR-1275 BCAT1 -0.092958576443477 0.78712696322568 0.278125072694851 0.588366914213911 MirTarget -0.26900679444838 3.21909889993658e-06 NA NA NA hsa-miR-320c BCAT1 -0.634817265516566 0.0229406911033521 0.278125072694851 0.588366914213911 MirTarget;miRanda;miRNATAP -0.156691295527843 0.0342471170657566 NA NA NA hsa-miR-320c BCHE -0.634817265516566 0.0229406911033521 0.368243358727627 0.443179972926346 miRanda -0.35447339358815 0.00346623980663696 NA NA NA hsa-miR-100-5p BCL10 -0.0835426508859793 0.958163253942357 -0.0416174096715336 0.955630620551855 miRNAWalker2_validate -0.161897883075394 3.7881326816172e-06 NA NA NA hsa-miR-153-3p BCL2 -0.0987811454818486 0.784243561444662 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.115035273015965 0.0323038102658718 19676043;21213215 Bioinformatics analysis revealed that anti-apoptosis family member B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 are potential targets of miR-153; Indeed Western blot analysis indicated that miR-153 downregulated both Bcl-2 and Mcl-1 at the protein levels; By luciferase reporter assays we further showed that miR-153 inhibited Bcl-2 and Mcl-1 expressions by directly targeting the 3'UTR regions of their respective mRNAs;Previously we established that microRNA-153 miR-153 induces apoptosis by downregulating B-cell lymphoma 2 Bcl-2 and myeloid cell leukemia sequence 1 Mcl-1 protein expression levels in glioblastoma cell line DBTRG-05MG ; B cell lymphoma;glioblastoma hsa-miR-15a-5p BCL2 0.114954548711096 0.902368422572956 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.221269651862381 0.0291079667853282 25623762;25594541;26915294;18931683;22335947 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 drug resistance;;poor survival;; colon cancer;breast cancer;lung cancer;prostate cancer;breast cancer hsa-miR-16-5p BCL2 0.174671689106251 0.884561260745118 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.229379064751398 0.0155316850668972 25623762;21336967;24447552;18449891;25435430;24598659;18931683;22966344 miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;P glycoprotein enhances radiation induced apoptotic cell death through the regulation of miR 16 and Bcl 2 expressions in hepatocellular carcinoma cells; RHepG2 cells the multidrug resistant subline of human hepatocellular carcinoma HepG2 cells expressed higher levels of Pgp as well as miR-16 and lower level of Bcl-2 than the parental cells; On the other hand ectopic mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells SK-HEP-1 cells MiHa cells and furthermore induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells; Moreover the enhancement effects of Pgp and miR-16 on radiation-induced apoptosis were counteracted by overexpression of Bcl-2;To study the expression of miR-16 and bcl-2 in T lymphoblastic lymphoma/leukemia T-LBL/ALL and its relationship to prognosis; The relationship of miR-16 and bcl-2 was significantP = 0.042χ2 = 4.147; The relationship of miR-16 and bcl-2 might suggested that gene regulation may be influenced by them;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2;We demonstrated that anti-apoptotic protein Bcl-2 was directly targeted miR-16 in paclitaxel resistant lung cancer cells; Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2;The miR-16 expression correlated with BCL-2 protein r = 0.51 P < 0.05;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;The overall objective of our investigation was to assess whether miRNA-16 miR-16 is involved in the regulation of critical genes such as BCL2 that control the sensitivity of pancreatic cancer cells to apoptosis; This study showed that the ectopic overexpression of miR-16 may be therapeutically beneficial as is evidenced by impaired cell survival with concomitant attenuation of anti-apoptotic protein Bcl-2; Moreover the luciferase reporter assay suggested that miR-16 post-transcriptionally regulates Bcl-2 expression in pancreatic cancer cells through the target sites of the 3' untranslated region of this gene drug resistance;;worse prognosis;drug resistance;;;;poor survival colon cancer;liver cancer;lymphoma;gastric cancer;lung cancer;lymphoma;prostate cancer;pancreatic cancer hsa-miR-17-5p BCL2 0.0171021356945324 0.989602604642911 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.313088312531828 1.57403483137732e-05 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-192-5p BCL2 0.0697292340294755 0.973773819800855 -0.442843407100756 0.346213669048136 miRNAWalker2_validate -0.227903685596688 0.000564938952369163 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-196b-5p BCL2 -0.41125693233305 0.786431671019602 -0.442843407100756 0.346213669048136 miRNAWalker2_validate -0.126443433292796 0.00925777817775241 NA NA NA hsa-miR-20a-3p BCL2 0.00457604227091757 0.993349143429143 -0.442843407100756 0.346213669048136 mirMAP -0.189828863199929 0.00114914427656055 NA NA NA hsa-miR-20a-5p BCL2 0.0315169008595895 0.979392076246529 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.252117244065233 0.000458303345864534 NA NA NA hsa-miR-224-3p BCL2 0.032422792414993 0.903234770603146 -0.442843407100756 0.346213669048136 mirMAP -0.178399757407561 0.00774691671641716 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-224-5p BCL2 0.00683420369444487 0.993472259403716 -0.442843407100756 0.346213669048136 mirMAP -0.301573774179688 5.62748011416914e-07 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 0.076830081157794 0.895711096248172 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.410993226860356 0.00011884046804375 NA NA NA hsa-miR-29a-3p BCL2 0.0440449516188579 0.980814196779775 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.340900217647213 0.00193580882132839 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29a-5p BCL2 0.0821355737825491 0.829907053101583 -0.442843407100756 0.346213669048136 mirMAP -0.343932614708693 5.20598038228022e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-29b-3p BCL2 0.00316507717068149 0.997967593788421 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase -0.269579801072406 0.00119448246860227 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-335-3p BCL2 -0.169930485068435 0.871151368030036 -0.442843407100756 0.346213669048136 mirMAP -0.24751331586752 0.0011768675011956 NA NA NA hsa-miR-33a-5p BCL2 -0.134015615925217 0.85242059599695 -0.442843407100756 0.346213669048136 mirMAP -0.128574385145016 0.00455510277772182 NA NA NA hsa-miR-374b-5p BCL2 -0.266960088707788 0.755383602539075 -0.442843407100756 0.346213669048136 mirMAP -0.287415339961428 0.0137036550670719 NA NA NA hsa-miR-450b-5p BCL2 0.148646457362083 0.720518619482493 -0.442843407100756 0.346213669048136 mirMAP -0.240978719259764 0.00585784315473669 NA NA NA hsa-miR-452-5p BCL2 -0.0374958705160777 0.968938070649671 -0.442843407100756 0.346213669048136 mirMAP -0.275409981212347 0.000609740122960845 NA NA NA hsa-miR-590-5p BCL2 -0.06413635524473 0.893491421748758 -0.442843407100756 0.346213669048136 miRanda -0.179521481010005 0.015541719980996 NA NA NA hsa-miR-7-5p BCL2 0.225803315354268 0.649729006199331 -0.442843407100756 0.346213669048136 miRNAWalker2_validate;miRTarBase;mirMAP -0.195234863896821 0.000177663908838853 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-125b-5p BCL3 0.00744496603712985 0.994576506820994 0.0243167262366155 0.976675633469126 miRNAWalker2_validate;miRTarBase -0.106181180748493 0.00139967976364451 20658525;25944662 MiR 125b targets BCL3 and suppresses ovarian cancer proliferation; This inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene BCL3;In ovarian cancer miR-125b has been shown to be downregulated and acts as a tumor suppressor by targeting proto-oncogene BCL3; Thus our results suggest that PPARγ can induce growth suppression of ovarian cancer by upregulating miR-125b which inhibition of proto-oncogene BCL3 ; ovarian cancer;ovarian cancer hsa-miR-10a-5p BCL6 -0.103091346403293 0.963361104257071 -0.0156544308638353 0.97923852304129 MirTarget;miRNATAP -0.198378140289362 0.000236067265425764 26590574 Luciferase reporter assay was used to analyze the regulation of miR-10a on the expression of BCL6; In addition miR-10a was found to target BCL6 and regulated its expression in transcription and translation levels; Correlation analysis revealed that the level of miR-10a in serum of AML patients was negatively correlated with BCL6 in BM-MSC acute myeloid leukemia hsa-miR-125b-5p BDH1 0.00744496603712985 0.994576506820994 0.0265388541900347 0.974997942420538 MirTarget -0.125359249134588 0.00190161505050062 NA NA NA hsa-miR-1275 BEGAIN -0.092958576443477 0.78712696322568 -0.238848919420317 0.419185610016661 MirTarget -0.191097669833692 0.00173613252420499 NA NA NA hsa-miR-222-3p BEND4 0.067264556454159 0.934147523407911 0.0254149536804462 0.965937640936152 mirMAP;miRNATAP -0.601275817777659 3.01080395929458e-05 NA NA NA hsa-miR-320c BEST1 -0.634817265516566 0.0229406911033521 0.110741109803457 0.577792706728918 mirMAP -0.131545858476033 0.00869718917698053 NA NA NA hsa-miR-320c BEX1 -0.634817265516566 0.0229406911033521 0.00806840603756465 0.988752513159951 miRanda -0.239194689101148 0.0363608927611166 NA NA NA hsa-miR-1275 BHLHE41 -0.092958576443477 0.78712696322568 0.271492521209189 0.6633425850953 MirTarget -0.202764236893498 0.000451418471623221 NA NA NA hsa-miR-222-3p BMF 0.067264556454159 0.934147523407911 -0.211369482252234 0.730350956686988 miRNATAP -0.334709560859811 2.18984133639837e-06 NA NA NA hsa-miR-1275 BMP3 -0.092958576443477 0.78712696322568 -0.260151363035626 0.667747479605921 MirTarget -0.31986959633417 0.0140452525423714 NA NA NA hsa-miR-1275 BMP6 -0.092958576443477 0.78712696322568 0.13163673368655 0.633912018384734 MirTarget -0.204466654307821 9.96857057523649e-06 NA NA NA hsa-miR-320c BNIP3 -0.634817265516566 0.0229406911033521 0.239720911809742 0.691857668652571 miRanda -0.256749953378393 0.00696335632705586 NA NA NA hsa-miR-1275 BNIP3L -0.092958576443477 0.78712696322568 -0.113473333494557 0.891436863952929 MirTarget -0.112430535985114 0.00123341844499643 NA NA NA hsa-miR-222-3p BPTF 0.067264556454159 0.934147523407911 -0.176526303943236 0.839965110775612 miRNAWalker2_validate -0.10326578134337 0.0011670556386004 NA NA NA hsa-miR-222-3p BRWD3 0.067264556454159 0.934147523407911 -0.331394870930052 0.559603702858761 MirTarget;miRNATAP -0.110399194454922 0.0490369701204261 NA NA NA hsa-miR-10a-5p BTBD11 -0.103091346403293 0.963361104257071 0.0776471656789074 0.821759500514693 miRNATAP -0.28238756834925 0.00896337078993014 NA NA NA hsa-miR-320c BVES -0.634817265516566 0.0229406911033521 0.03735903293648 0.900277277583011 miRanda;miRNATAP -0.210362133080968 0.00532363207065997 NA NA NA hsa-miR-125b-5p C18orf25 0.00744496603712985 0.994576506820994 -0.00499214375491874 0.993577946633362 miRNATAP -0.112189885968156 2.31577666059883e-05 NA NA NA hsa-miR-1226-3p C1QTNF9 -0.151739505908207 0.574216796013786 0.181829997885309 0.688829565330586 MirTarget -0.284199483019159 0.00216039973500406 NA NA NA hsa-miR-590-3p C1QTNF9 0.0829620326684548 0.810708708264937 0.181829997885309 0.688829565330586 miRanda -0.235132844680909 0.0150480643955597 NA NA NA hsa-miR-1275 C2CD4C -0.092958576443477 0.78712696322568 -0.280010195583473 0.405113746950575 MirTarget -0.294011146424443 1.46492490631912e-05 NA NA NA hsa-miR-222-3p C3orf70 0.067264556454159 0.934147523407911 -0.00575055773344646 0.990840549718386 miRNATAP -0.413756827830026 4.96755416541954e-05 NA NA NA hsa-miR-1275 C5AR1 -0.092958576443477 0.78712696322568 0.239037175028063 0.628961147792247 MirTarget -0.263620340419225 6.58023130041069e-06 NA NA NA hsa-miR-320c C5AR1 -0.634817265516566 0.0229406911033521 0.239037175028063 0.628961147792247 miRanda -0.172593846894486 0.0209401301134599 NA NA NA hsa-miR-140-5p C7 0.0504361217652773 0.944528924085181 -0.0190334712672604 0.97498463013546 miRanda -0.562689084392309 0.0407187932689078 NA NA NA hsa-miR-193a-3p C7 -0.0757639382885689 0.833054724049432 -0.0190334712672604 0.97498463013546 miRanda -0.570201348306563 0.00110372267151477 NA NA NA hsa-miR-375 C7 -0.132596291751662 0.946715860650232 -0.0190334712672604 0.97498463013546 miRanda;miRNATAP -0.571959996195528 8.67577067452209e-07 NA NA NA hsa-miR-421 C7 -0.226934983690969 0.526580030309737 -0.0190334712672604 0.97498463013546 miRanda -0.789009056684234 7.7133486222039e-06 NA NA NA hsa-miR-514a-3p C7 0.192170221446086 0.676313473391544 -0.0190334712672604 0.97498463013546 miRNATAP -0.321087059244676 0.000152697348516626 NA NA NA hsa-miR-590-3p C7 0.0829620326684548 0.810708708264937 -0.0190334712672604 0.97498463013546 miRanda;mirMAP -1.14112069077644 8.45729944570846e-15 NA NA NA hsa-miR-590-5p C7 -0.06413635524473 0.893491421748758 -0.0190334712672604 0.97498463013546 miRanda -1.34905733610047 8.92413539714544e-19 NA NA NA hsa-miR-222-3p CACNB4 0.067264556454159 0.934147523407911 0.165725985049159 0.633278718873103 miRNATAP -0.547583239952331 3.51008719457231e-06 NA NA NA hsa-miR-10a-5p CADM1 -0.103091346403293 0.963361104257071 0.136106523681135 0.766812118774661 MirTarget;miRNATAP -0.358967109262617 0.000547679531619127 NA NA NA hsa-miR-10a-5p CADM2 -0.103091346403293 0.963361104257071 0.278818941627126 0.709131976511408 MirTarget;miRNATAP -0.316181037512832 0.0133805854706457 NA NA NA hsa-miR-320c CADM2 -0.634817265516566 0.0229406911033521 0.278818941627126 0.709131976511408 miRanda -0.223506788316691 0.0345478696293737 NA NA NA hsa-miR-1275 CADM3 -0.092958576443477 0.78712696322568 -0.109253352399299 0.842361523766233 MirTarget;mirMAP -0.572140917395053 7.12243149855186e-07 NA NA NA hsa-miR-1275 CALB2 -0.092958576443477 0.78712696322568 1.32083480030308 0.0190230949466106 MirTarget -0.48383517010633 7.05355116902092e-05 NA NA NA hsa-miR-1275 CALD1 -0.092958576443477 0.78712696322568 0.0956531021446771 0.929797173738814 MirTarget -0.276009731610994 7.02984825208389e-07 NA NA NA hsa-miR-320c CALD1 -0.634817265516566 0.0229406911033521 0.0956531021446771 0.929797173738814 PITA;miRanda;miRNATAP -0.184049584511728 0.00988105121405779 NA NA NA hsa-miR-1275 CAMK2N2 -0.092958576443477 0.78712696322568 -0.0278935730433179 0.934621698912436 mirMAP -0.184620065576381 0.00575024031360565 NA NA NA hsa-miR-320c CAP2 -0.634817265516566 0.0229406911033521 0.27913267396188 0.454382623583972 miRanda -0.193025785030725 0.00424284874739615 NA NA NA hsa-miR-143-3p CASP8 -0.0402404826858778 0.987317207979986 -0.162072130949515 0.831567187928954 MirTarget -0.109420620201972 0.000545823380266859 NA NA NA hsa-miR-320c CASQ2 -0.634817265516566 0.0229406911033521 -0.472480322882836 0.452663966590871 miRanda -0.397931852108838 0.0155137504928163 NA NA NA hsa-miR-451a CAV1 -0.150707356551769 0.885791087039658 0.0457679421693724 0.952424955947835 MirTarget -0.105838390688806 0.0308749698505536 NA NA NA hsa-miR-10a-5p CBX6 -0.103091346403293 0.963361104257071 -0.234439921918545 0.663380200056587 mirMAP -0.469266009633015 1.33488792232478e-07 NA NA NA hsa-miR-1275 CBX6 -0.092958576443477 0.78712696322568 -0.234439921918545 0.663380200056587 MirTarget;mirMAP -0.162868579056009 0.00649475758560163 NA NA NA hsa-miR-106a-5p CBX7 -0.220241577853689 0.671337298786352 -0.130733598570433 0.846119299780212 mirMAP -0.239348272164892 2.33032874529859e-06 NA NA NA hsa-miR-106b-5p CBX7 0.0054863796897946 0.996055976715358 -0.130733598570433 0.846119299780212 mirMAP -0.349789476024796 1.39246038711085e-09 NA NA NA hsa-miR-1254 CBX7 -0.241680582868541 0.411875416037286 -0.130733598570433 0.846119299780212 MirTarget -0.176552703661639 1.48820044218813e-05 NA NA NA hsa-miR-17-5p CBX7 0.0171021356945324 0.989602604642911 -0.130733598570433 0.846119299780212 mirMAP -0.327923664079336 2.32488951431698e-14 NA NA NA hsa-miR-181a-2-3p CBX7 0.0507339645148903 0.968005506930392 -0.130733598570433 0.846119299780212 mirMAP -0.234877431518298 0.000130563057519204 NA NA NA hsa-miR-181a-5p CBX7 0.0759650782391361 0.955324432882321 -0.130733598570433 0.846119299780212 MirTarget;miRNATAP -0.227345077678761 0.000282394052638819 NA NA NA hsa-miR-181b-5p CBX7 0.0792125712512002 0.94249452124277 -0.130733598570433 0.846119299780212 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.289850371119917 1.48100111826177e-06 NA NA NA hsa-miR-181d-5p CBX7 -0.210213661364991 0.760189168632722 -0.130733598570433 0.846119299780212 MirTarget -0.10498042944421 0.0139124232286868 NA NA NA hsa-miR-186-5p CBX7 -0.103524789975763 0.922074318057442 -0.130733598570433 0.846119299780212 mirMAP -0.304518849077862 2.42694021600095e-05 NA NA NA hsa-miR-18a-3p CBX7 -0.166644537390572 0.596581925973113 -0.130733598570433 0.846119299780212 MirTarget;miRNATAP -0.17673989736719 1.94827129931583e-06 NA NA NA hsa-miR-19a-3p CBX7 0.00832123546817964 0.989990781976872 -0.130733598570433 0.846119299780212 mirMAP;miRNATAP -0.22824976202166 6.27682099582467e-08 NA NA NA hsa-miR-19b-3p CBX7 -0.0507144410170453 0.959611428611728 -0.130733598570433 0.846119299780212 mirMAP;miRNATAP -0.217617318525181 2.05161185621906e-05 NA NA NA hsa-miR-20a-5p CBX7 0.0315169008595895 0.979392076246529 -0.130733598570433 0.846119299780212 mirMAP -0.298940674482154 2.77395005458313e-12 NA NA NA hsa-miR-222-5p CBX7 0.230242251748825 0.580866086852678 -0.130733598570433 0.846119299780212 mirMAP -0.278546196147821 5.00753084887658e-13 NA NA NA hsa-miR-224-5p CBX7 0.00683420369444487 0.993472259403716 -0.130733598570433 0.846119299780212 MirTarget -0.112598498483365 0.00305967122372181 NA NA NA hsa-miR-330-5p CBX7 -0.161700913340185 0.829117653754131 -0.130733598570433 0.846119299780212 mirMAP -0.152532728339444 0.025483111615283 NA NA NA hsa-miR-331-3p CBX7 0.0205707543180207 0.971480958709634 -0.130733598570433 0.846119299780212 MirTarget -0.234493571047585 2.17000263945203e-05 NA NA NA hsa-miR-421 CBX7 -0.226934983690969 0.526580030309737 -0.130733598570433 0.846119299780212 miRNAWalker2_validate;miRTarBase;mirMAP -0.285760375845697 3.14359498930237e-09 19802518 Inhibition of miR-421 expression decreased the growth of both MGC-803 and SGC-7901 gastric cancer cells in vitro with up-regulating the expression of its cancer-related target genes CBX7 and RBMXL1 miR-421 may involve in the early stage of stomach carcinogenesis and could be used as an efficient diagnostic biomarker staging;tumorigenesis gastric cancer hsa-miR-423-3p CBX7 -0.147631086875983 0.869289026105224 -0.130733598570433 0.846119299780212 MirTarget -0.266489398396383 5.48500594983518e-06 NA NA NA hsa-miR-502-5p CBX7 -0.0377406031257114 0.882990388343512 -0.130733598570433 0.846119299780212 mirMAP -0.127241177303372 0.00275589336385996 NA NA NA hsa-miR-505-3p CBX7 -0.176520656034591 0.807542265301582 -0.130733598570433 0.846119299780212 mirMAP -0.248774417636697 5.89451026407682e-05 NA NA NA hsa-miR-577 CBX7 -0.709022386979996 0.309866560581154 -0.130733598570433 0.846119299780212 PITA;miRNATAP -0.126963590501475 1.73149537680593e-06 NA NA NA hsa-miR-589-3p CBX7 -0.0626170938535065 0.807656131646557 -0.130733598570433 0.846119299780212 mirMAP -0.136923216805431 0.000660908548135929 NA NA NA hsa-miR-590-3p CBX7 0.0829620326684548 0.810708708264937 -0.130733598570433 0.846119299780212 miRanda;miRNATAP -0.158118069471417 0.000242243530050678 NA NA NA hsa-miR-625-5p CBX7 -0.056828555048515 0.872636803307556 -0.130733598570433 0.846119299780212 MirTarget;mirMAP -0.107964073724726 0.00462439585590311 NA NA NA hsa-miR-7-1-3p CBX7 -0.126737838158129 0.846416009084243 -0.130733598570433 0.846119299780212 mirMAP -0.18724012819561 0.00020687020142979 NA NA NA hsa-miR-769-5p CBX7 -0.0357435722837058 0.948958732906016 -0.130733598570433 0.846119299780212 miRNATAP -0.385334184754707 6.39506790345994e-09 NA NA NA hsa-miR-93-5p CBX7 -0.093851027778495 0.955646810234554 -0.130733598570433 0.846119299780212 mirMAP -0.403022896855233 4.29150991202981e-14 NA NA NA hsa-miR-320c CCDC102B -0.634817265516566 0.0229406911033521 0.326794568487986 0.163705669901388 miRanda -0.128834629280529 0.021847044512817 NA NA NA hsa-miR-1275 CCDC3 -0.092958576443477 0.78712696322568 0.0563083652003891 0.920566333874611 MirTarget -0.116386625840981 0.00464492866420482 NA NA NA hsa-miR-143-3p CCDC58 -0.0402404826858778 0.987317207979986 0.0340376508229525 0.953767320536182 MirTarget;miRNATAP -0.196398475696333 5.98719899921817e-05 NA NA NA hsa-miR-146b-3p CCDC7 0.123478581084377 0.879342747149801 -0.0562208634419006 0.747642769579458 miRNATAP -0.114807115077818 0.0030371325233711 NA NA NA hsa-miR-1275 CCL22 -0.092958576443477 0.78712696322568 -0.452963877250121 0.24034209318043 MirTarget -0.162221738912743 0.0211107497584579 NA NA NA hsa-miR-320c CCL7 -0.634817265516566 0.0229406911033521 0.834671305388364 0.170933737700037 miRanda -0.41670805806655 0.000383144812381231 NA NA NA hsa-miR-1275 CCL8 -0.092958576443477 0.78712696322568 1.16412841585401 0.0117713456068505 MirTarget -0.533726592186162 1.40649820935236e-08 NA NA NA hsa-miR-125b-5p CCNE1 0.00744496603712985 0.994576506820994 0.0226549648190808 0.964365517863054 miRNAWalker2_validate -0.153080131670566 0.000743418271995361 NA NA NA hsa-miR-100-5p CCNG1 -0.0835426508859793 0.958163253942357 0.108877378420312 0.909218648339877 miRNAWalker2_validate -0.122150346233984 0.000747967078030819 NA NA NA hsa-miR-320c CCR1 -0.634817265516566 0.0229406911033521 0.183499598997037 0.674325494405919 miRanda -0.152553027820544 0.0326636035435914 NA NA NA hsa-miR-1275 CD1C -0.092958576443477 0.78712696322568 -0.581140787279273 0.135064563367306 MirTarget -0.213576456391813 0.00782988334417675 NA NA NA hsa-miR-320c CD1D -0.634817265516566 0.0229406911033521 0.13498743738827 0.60969893528334 miRanda -0.140204896988282 0.0268510897419336 NA NA NA hsa-miR-1275 CD300LB -0.092958576443477 0.78712696322568 0.0560977317090097 0.872610089310015 MirTarget -0.26504143699906 3.92067125917694e-05 NA NA NA hsa-miR-125b-5p CD320 0.00744496603712985 0.994576506820994 -0.0128799919397595 0.988624938833687 miRNAWalker2_validate -0.118888724533362 0.00252936532308999 NA NA NA hsa-miR-1275 CD34 -0.092958576443477 0.78712696322568 0.148128983859828 0.834072795795696 MirTarget -0.162760834287745 2.47101533580903e-06 NA NA NA hsa-miR-1275 CD3E -0.092958576443477 0.78712696322568 -0.160310492432107 0.737682364654018 MirTarget -0.20329823756322 0.00183205887589508 NA NA NA hsa-miR-222-3p CD4 0.067264556454159 0.934147523407911 0.0158888593652646 0.981994675306851 MirTarget;miRNATAP -0.418542229502118 2.62245189299617e-05 NA NA NA hsa-miR-1275 CD7 -0.092958576443477 0.78712696322568 -0.0857792413847314 0.842651471727949 MirTarget -0.255128283884589 0.000303707279679273 NA NA NA hsa-miR-1275 CD80 -0.092958576443477 0.78712696322568 0.0672072094770476 0.829570740641897 MirTarget -0.266748582584092 1.90901636483664e-05 NA NA NA hsa-miR-125b-5p CDC42BPG 0.00744496603712985 0.994576506820994 -0.166066234866205 0.81114434678514 MirTarget;miRNATAP -0.16164926023992 6.35207750288888e-05 NA NA NA hsa-miR-320c CDH19 -0.634817265516566 0.0229406911033521 0.198868622954813 0.771224374886639 miRanda -0.355554797817945 0.00884751788938644 NA NA NA hsa-miR-222-3p CDK19 0.067264556454159 0.934147523407911 -0.176488953986863 0.802397302761007 MirTarget;miRNATAP -0.127112410559829 0.000300618839739334 NA NA NA hsa-miR-222-3p CDKL5 0.067264556454159 0.934147523407911 -0.579796605351064 0.0638181827876205 miRNAWalker2_validate -0.587357165762904 1.18723577262382e-07 NA NA NA hsa-miR-451a CDKN2B -0.150707356551769 0.885791087039658 0.317673594816384 0.60547325902781 MirTarget -0.127335270080349 0.0369741455561906 NA NA NA hsa-miR-1275 CDR2L -0.092958576443477 0.78712696322568 -0.020783962276667 0.973722766465721 MirTarget -0.177817161691142 7.17545741587051e-06 NA NA NA hsa-miR-1275 CDYL2 -0.092958576443477 0.78712696322568 0.090646427020913 0.736207541363025 MirTarget -0.147917899099114 0.00864524771918069 NA NA NA hsa-miR-10a-5p CECR6 -0.103091346403293 0.963361104257071 -0.510891639354667 0.0477113125457109 MirTarget;miRNATAP -0.260664607617451 0.00055957974860992 NA NA NA hsa-miR-10a-5p CELF2 -0.103091346403293 0.963361104257071 0.165737506592831 0.827590601765985 miRNATAP -0.129250068555913 0.0404114855539083 NA NA NA hsa-miR-125b-5p CENPO 0.00744496603712985 0.994576506820994 -0.0745508084556685 0.874691217835134 mirMAP -0.142013133619855 3.1188291784118e-07 NA NA NA hsa-miR-143-3p CENPP -0.0402404826858778 0.987317207979986 0.164682665551449 0.635843281594895 mirMAP -0.135586881569025 0.00887343010303629 NA NA NA hsa-miR-1275 CERCAM -0.092958576443477 0.78712696322568 0.309808354135801 0.678621770762591 MirTarget -0.254244190311684 5.56147185480744e-06 NA NA NA hsa-miR-320c CFL2 -0.634817265516566 0.0229406911033521 -0.00429221099212107 0.993302086631373 miRanda -0.160021994932787 0.00189927812539133 NA NA NA hsa-miR-10a-5p CHD5 -0.103091346403293 0.963361104257071 0.2573606597222 0.556549021013887 mirMAP -0.303912033909915 0.0106054943484389 NA NA NA hsa-miR-1275 CHD5 -0.092958576443477 0.78712696322568 0.2573606597222 0.556549021013887 MirTarget -0.163409376018429 0.0370264275167866 NA NA NA hsa-miR-10a-5p CHFR -0.103091346403293 0.963361104257071 0.235179046656886 0.706282868338332 miRNAWalker2_validate -0.256308178026215 0.00115650363295381 NA NA NA hsa-miR-320c CHGA -0.634817265516566 0.0229406911033521 0.841140509825103 0.252641115953171 PITA;miRanda;miRNATAP -0.541271979754467 0.00739141457698243 NA NA NA hsa-miR-143-3p CHKA -0.0402404826858778 0.987317207979986 -0.0449279032417742 0.949731848365796 MirTarget -0.147421813758736 0.0059515135085912 NA NA NA hsa-miR-10a-5p CHL1 -0.103091346403293 0.963361104257071 -0.21473791421855 0.62739270601731 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.598868882046198 1.35262799699144e-05 22634495 MicroRNA 10a targets CHL1 and promotes cell growth migration and invasion in human cervical cancer cells; Subsequently CHL1 is confirmed as a target of miR-10a and is negatively regulated by miR-10a at mRNA and protein levels; Finally overexpression of CHL1 lacked the 3'UTR abolished the effects of miR-10a cervical and endocervical cancer hsa-miR-10a-5p CHST11 -0.103091346403293 0.963361104257071 0.127383180842358 0.741167055165 mirMAP -0.379606596518278 5.72211868892772e-06 NA NA NA hsa-miR-320c CHST15 -0.634817265516566 0.0229406911033521 0.216686798360107 0.714632329958521 mirMAP -0.144979078902628 0.0296510697775658 NA NA NA hsa-miR-1275 CHST3 -0.092958576443477 0.78712696322568 0.0820856840369419 0.881960208226164 mirMAP -0.245751003927829 1.84504069966261e-06 NA NA NA hsa-miR-320c CHSY3 -0.634817265516566 0.0229406911033521 0.275176307262694 0.303992084177399 miRanda -0.178556228704071 0.00571106313673737 NA NA NA hsa-miR-143-3p CIT -0.0402404826858778 0.987317207979986 -0.152552378088854 0.834055818036413 miRNATAP -0.205207699951373 0.000104565291848577 NA NA NA hsa-miR-1275 CLDN11 -0.092958576443477 0.78712696322568 0.36476815283166 0.317151248304736 MirTarget -0.197468338176128 0.0121167658294528 NA NA NA hsa-miR-222-3p CLDN11 0.067264556454159 0.934147523407911 0.36476815283166 0.317151248304736 MirTarget -0.648986969812316 1.64517048960368e-06 NA NA NA hsa-miR-1275 CLEC5A -0.092958576443477 0.78712696322568 0.184877705754422 0.623717981301092 MirTarget -0.395858832587665 9.6841610454083e-08 NA NA NA hsa-miR-320c CLIP4 -0.634817265516566 0.0229406911033521 0.117014894588724 0.75478172294096 miRanda -0.224114681173649 0.00681830125700127 NA NA NA hsa-miR-125b-5p CLN6 0.00744496603712985 0.994576506820994 -0.0363335035272838 0.966743248228381 MirTarget -0.137074977089046 2.90605192677173e-06 NA NA NA hsa-miR-143-3p CLSPN -0.0402404826858778 0.987317207979986 -0.284177866576038 0.518820992499961 MirTarget -0.162449002863809 0.0256558702037762 NA NA NA hsa-miR-143-3p CMPK1 -0.0402404826858778 0.987317207979986 0.035137031947011 0.975166990291302 miRNATAP -0.147958881258474 0.000579188279745608 NA NA NA hsa-miR-320c CMTM3 -0.634817265516566 0.0229406911033521 0.209840269973403 0.740913217157347 miRanda -0.145030739199947 0.00889113497762507 NA NA NA hsa-miR-1275 CNDP1 -0.092958576443477 0.78712696322568 0.264691934956332 0.729596904337196 MirTarget -0.23635519642498 0.0255315793877025 NA NA NA hsa-miR-10a-5p CNN1 -0.103091346403293 0.963361104257071 0.0562043047158607 0.943037682519124 MirTarget -0.762922397228861 8.19284297172856e-09 NA NA NA hsa-miR-1275 CNNM1 -0.092958576443477 0.78712696322568 -0.121033563384494 0.766117037722178 MirTarget -0.173548460786865 0.0254596280333712 NA NA NA hsa-miR-320c CNRIP1 -0.634817265516566 0.0229406911033521 0.0526206265137845 0.87480833678484 miRanda -0.138828385212659 0.0132466919435407 NA NA NA hsa-miR-10a-5p CNTLN -0.103091346403293 0.963361104257071 -0.0524619798308081 0.889203498834834 miRNAWalker2_validate -0.178408609269104 0.0240279584539169 NA NA NA hsa-miR-10a-5p CNTN2 -0.103091346403293 0.963361104257071 -0.401215497768751 0.512369809376981 mirMAP -0.550082433642636 5.26284637503469e-05 NA NA NA hsa-miR-1275 CNTNAP1 -0.092958576443477 0.78712696322568 0.0318138751218084 0.949774251799532 MirTarget;PITA -0.238373791975133 4.01242944368552e-05 NA NA NA hsa-miR-1275 COL1A2 -0.092958576443477 0.78712696322568 0.315217295706258 0.834843430608183 MirTarget -0.267342019012468 4.82635789352029e-05 NA NA NA hsa-miR-320c COL24A1 -0.634817265516566 0.0229406911033521 0.0725462724540124 0.847648951037012 MirTarget;PITA;miRanda -0.323460509144941 0.00118478925303842 NA NA NA hsa-miR-10a-5p COL4A2 -0.103091346403293 0.963361104257071 0.1294954789774 0.91754726742583 miRNAWalker2_validate -0.351874489991799 3.509559305596e-09 NA NA NA hsa-miR-10a-5p COL4A3 -0.103091346403293 0.963361104257071 0.130332862208255 0.825410778911627 miRNAWalker2_validate -0.565097167910671 0.000310682819823591 NA NA NA hsa-miR-222-3p COL5A2 0.067264556454159 0.934147523407911 0.190638177458304 0.860149581079665 miRNAWalker2_validate -0.496243769261014 1.16422707681611e-06 NA NA NA hsa-miR-10a-5p COL6A2 -0.103091346403293 0.963361104257071 0.136672609145188 0.910620082143014 miRNAWalker2_validate -0.509117494269021 1.45906987251488e-10 NA NA NA hsa-miR-320c COL6A3 -0.634817265516566 0.0229406911033521 0.0471740815717965 0.97067551196885 miRanda -0.189143013461543 0.0184407286948916 NA NA NA hsa-miR-320c COLEC12 -0.634817265516566 0.0229406911033521 0.28311464321697 0.544275951340155 miRanda -0.229801134402865 0.0246012498669218 NA NA NA hsa-miR-125b-5p CORO2A 0.00744496603712985 0.994576506820994 0.0582286326369008 0.946471913983363 MirTarget;miRNATAP -0.107383291582431 0.00819654747891511 NA NA NA hsa-miR-27b-5p CORO6 -0.0631880671771778 0.89873384691188 0.378621066835443 0.266059521621696 mirMAP -0.29190444180989 0.0263278973736704 NA NA NA hsa-miR-29a-3p CORO6 0.0440449516188579 0.980814196779775 0.378621066835443 0.266059521621696 miRNATAP -0.601769702759738 2.67750402989337e-07 NA NA NA hsa-miR-29b-3p CORO6 0.00316507717068149 0.997967593788421 0.378621066835443 0.266059521621696 miRNATAP -0.480540573180287 5.20272565119122e-08 NA NA NA hsa-miR-100-5p COX5A -0.0835426508859793 0.958163253942357 0.0591493164363133 0.952079713063206 miRNAWalker2_validate -0.210290606876506 1.24663968768937e-11 NA NA NA hsa-miR-320c CPEB1 -0.634817265516566 0.0229406911033521 0.0121072779066176 0.984205470134471 MirTarget;PITA;miRanda;miRNATAP -0.290541766022349 0.00750066435166796 NA NA NA hsa-miR-222-3p CPNE8 0.067264556454159 0.934147523407911 -0.135691016274836 0.715411035272007 MirTarget;miRNATAP -0.341270503310919 0.000166929801228176 NA NA NA hsa-miR-320c CPNE8 -0.634817265516566 0.0229406911033521 -0.135691016274836 0.715411035272007 miRanda -0.160516311702771 0.0143719997086566 NA NA NA hsa-miR-1275 CPS1 -0.092958576443477 0.78712696322568 -0.69102137317683 0.259995357005067 MirTarget -0.403294177781663 0.0022197592898672 NA NA NA hsa-miR-143-3p CREBZF -0.0402404826858778 0.987317207979986 0.0120174972186708 0.988903521597433 MirTarget -0.12628518070541 0.000108511235981109 NA NA NA hsa-miR-1275 CSDC2 -0.092958576443477 0.78712696322568 0.180031052970228 0.659930058138444 mirMAP -0.323230570644312 0.000226035137516061 NA NA NA hsa-miR-1275 CSF1R -0.092958576443477 0.78712696322568 0.0459680305536381 0.947025638958489 MirTarget -0.28098420617344 8.4192050908413e-06 NA NA NA hsa-miR-320c CSRP2 -0.634817265516566 0.0229406911033521 0.269041610475407 0.502847453818653 miRanda -0.126492548122754 0.00763318835747427 NA NA NA hsa-miR-1275 CTNND2 -0.092958576443477 0.78712696322568 -0.378338640159358 0.557186118857965 MirTarget -0.259070370416217 0.00156271979586981 NA NA NA hsa-miR-1275 CTSB -0.092958576443477 0.78712696322568 0.0882932383723283 0.948662496839359 MirTarget -0.118078599233595 0.000159718167710873 NA NA NA hsa-miR-10a-5p CX3CL1 -0.103091346403293 0.963361104257071 -0.449710406911942 0.504155621534746 mirMAP -0.150940334882007 0.0407802938160288 NA NA NA hsa-miR-1275 CXCL12 -0.092958576443477 0.78712696322568 -0.276709962563793 0.67601982809546 MirTarget -0.153116107445263 0.00929242096788209 NA NA NA hsa-miR-222-3p CXCL12 0.067264556454159 0.934147523407911 -0.276709962563793 0.67601982809546 MirTarget -0.656030666521881 3.40642247439424e-11 NA NA NA hsa-miR-320c CYBRD1 -0.634817265516566 0.0229406911033521 0.275992299706185 0.728432746998709 miRanda -0.179596210665027 0.0171307549474778 NA NA NA hsa-miR-222-3p CYP1B1 0.067264556454159 0.934147523407911 0.43221337287893 0.371537198241456 MirTarget -0.811160973147013 2.91002326157443e-07 NA NA NA hsa-miR-320c CYTL1 -0.634817265516566 0.0229406911033521 0.116727441712334 0.788563455558349 miRanda -0.203325487635466 0.034080833469045 NA NA NA hsa-miR-1275 DCLK1 -0.092958576443477 0.78712696322568 -0.4243088904526 0.289858272021904 MirTarget -0.339619798279513 6.66980854060519e-05 NA NA NA hsa-miR-320c DCN -0.634817265516566 0.0229406911033521 -0.162584974399422 0.876526614156692 miRanda -0.189984646255035 0.027516021022589 NA NA NA hsa-miR-100-5p DDAH1 -0.0835426508859793 0.958163253942357 -0.228355808340793 0.82173653803895 miRNAWalker2_validate -0.13800417516577 4.17616728391237e-05 NA NA NA hsa-miR-222-3p DENND1B 0.067264556454159 0.934147523407911 -0.0895386949733048 0.754239150959776 miRNATAP -0.19553533348579 0.000760485513366205 NA NA NA hsa-miR-125b-5p DGAT1 0.00744496603712985 0.994576506820994 0.0651086860263499 0.947259853035266 miRNAWalker2_validate;miRTarBase -0.162395274121098 0.000167645830908387 NA NA NA hsa-miR-222-3p DIRAS3 0.067264556454159 0.934147523407911 0.359625238190755 0.256351249549928 miRTarBase -0.219985290621216 0.0380447313187539 NA NA NA hsa-miR-143-3p DLG3 -0.0402404826858778 0.987317207979986 -0.0472322979299991 0.960204730970797 MirTarget;miRNATAP -0.254040094009113 3.52326164623278e-08 NA NA NA hsa-miR-10a-5p DLG4 -0.103091346403293 0.963361104257071 0.297496742654258 0.435858704642526 miRNAWalker2_validate -0.257467064500736 1.76947474223369e-05 NA NA NA hsa-miR-1275 DMBT1 -0.092958576443477 0.78712696322568 -0.388763905824642 0.722790558138778 MirTarget -0.434394751960852 0.00894504230489552 NA NA NA hsa-miR-143-3p DNAJB1 -0.0402404826858778 0.987317207979986 0.143072012313719 0.895970349194723 miRNATAP -0.137762098327825 0.00657516634428274 NA NA NA hsa-miR-320c DNAJB5 -0.634817265516566 0.0229406911033521 -0.0245734329520504 0.950616742858987 miRanda -0.194222698155352 0.00163531923155492 NA NA NA hsa-miR-320c DNAJC5B -0.634817265516566 0.0229406911033521 0.495336601692644 0.264658862674866 miRanda -0.195040294849489 0.0470499070471433 NA NA NA hsa-miR-320c DOK3 -0.634817265516566 0.0229406911033521 0.235069635448701 0.542396648717612 miRanda -0.115737614631135 0.0427538884091505 NA NA NA hsa-miR-320c DOK6 -0.634817265516566 0.0229406911033521 -0.16350531143568 0.561442772801044 mirMAP;miRNATAP -0.152160841925303 0.0377059238252102 NA NA NA hsa-miR-1275 DPP6 -0.092958576443477 0.78712696322568 -0.0156227368181687 0.979915588318066 PITA -0.366414703753167 0.00016410473239405 NA NA NA hsa-miR-222-3p DPP8 0.067264556454159 0.934147523407911 -0.151450410581773 0.793976845658715 miRNAWalker2_validate;MirTarget -0.144556107289298 0.000531048333215138 NA NA NA hsa-miR-222-3p DPY19L3 0.067264556454159 0.934147523407911 -0.122665557016696 0.823296103770263 MirTarget -0.16946811075017 0.000265617996140071 NA NA NA hsa-miR-320c DSEL -0.634817265516566 0.0229406911033521 0.0659126634295149 0.824274966997191 mirMAP -0.173227756197913 0.014478818374586 NA NA NA hsa-miR-222-3p DST 0.067264556454159 0.934147523407911 -0.0605879767457829 0.950531311652521 mirMAP -0.247871385753389 3.18436072507833e-05 NA NA NA hsa-miR-1275 DTNA -0.092958576443477 0.78712696322568 -0.133702097680304 0.771524870282741 MirTarget -0.187315026302521 0.0409750082337406 NA NA NA hsa-miR-320c DYNC1I1 -0.634817265516566 0.0229406911033521 -0.605923391526436 0.126189191717052 miRanda -0.229143959890055 0.0249046649914851 NA NA NA hsa-miR-1275 DYSF -0.092958576443477 0.78712696322568 -0.0154122410005755 0.979753160016833 MirTarget -0.199049453238412 1.70145596530502e-05 NA NA NA hsa-miR-320c DZIP1 -0.634817265516566 0.0229406911033521 0.0913320238516777 0.803443743772193 miRanda -0.190854466154028 0.00575921554308779 NA NA NA hsa-miR-125b-5p E2F2 0.00744496603712985 0.994576506820994 0.0259858590816009 0.962906482066284 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.235790107017282 1.22460526383478e-06 22999819 miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2 glioblastoma hsa-miR-125b-5p E2F7 0.00744496603712985 0.994576506820994 -0.00667424105081604 0.988144634023614 miRNAWalker2_validate -0.206534211525212 5.76667724491123e-06 NA NA NA hsa-miR-125b-5p EAF1 0.00744496603712985 0.994576506820994 -0.0371775056504582 0.962888667359799 MirTarget;miRNATAP -0.101854342397092 3.86516223273812e-10 NA NA NA hsa-miR-10a-5p EBF1 -0.103091346403293 0.963361104257071 0.0723185324351311 0.805841864008836 miRNATAP -0.456797563038746 7.6507095047642e-10 NA NA NA hsa-miR-1275 EBF1 -0.092958576443477 0.78712696322568 0.0723185324351311 0.805841864008836 MirTarget -0.187102672617445 0.000189519406325993 NA NA NA hsa-miR-1275 EFNA5 -0.092958576443477 0.78712696322568 0.423582364078908 0.346471649392702 mirMAP -0.336952379729342 0.000142905613045414 NA NA NA hsa-miR-320c EFS -0.634817265516566 0.0229406911033521 0.0641035889526762 0.850915473530994 PITA;miRanda;miRNATAP -0.203305328498545 0.00248229263182715 NA NA NA hsa-miR-125b-5p EIF4EBP1 0.00744496603712985 0.994576506820994 0.00937843333316302 0.990782660249316 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.140179204025962 0.00143796990077998 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-125b-5p EIF5 0.00744496603712985 0.994576506820994 -0.063127170147224 0.9541008439445 miRNAWalker2_validate -0.115990289650456 2.79271543972921e-06 NA NA NA hsa-miR-100-5p EIF5A -0.0835426508859793 0.958163253942357 0.0563018054774762 0.9638656455967 miRNAWalker2_validate -0.188835408798341 2.24347867585198e-08 NA NA NA hsa-miR-100-5p EIF5AL1 -0.0835426508859793 0.958163253942357 0.00783372235784618 0.99333352963921 miRNAWalker2_validate -0.170161389562216 4.21071697093763e-07 NA NA NA hsa-miR-10a-5p ELAVL2 -0.103091346403293 0.963361104257071 -0.201001218809861 0.726321471605612 MirTarget;miRNATAP -0.428281208588504 0.0163647805647984 NA NA NA hsa-miR-10a-5p ELOVL2 -0.103091346403293 0.963361104257071 0.344647368764876 0.417920107347652 miRNAWalker2_validate -0.432063987484433 3.04461978847792e-05 NA NA NA hsa-miR-125b-5p ELOVL6 0.00744496603712985 0.994576506820994 0.17349613462884 0.800207382174054 MirTarget;miRNATAP -0.204312677935487 3.75817084722736e-06 NA NA NA hsa-miR-143-3p EME1 -0.0402404826858778 0.987317207979986 -0.0101177584669672 0.976406049348482 MirTarget -0.284639516596518 7.45069199697836e-06 NA NA NA hsa-miR-1275 EMILIN1 -0.092958576443477 0.78712696322568 0.0873345636975111 0.925593253578111 MirTarget -0.231566709646157 4.26732596452337e-05 NA NA NA hsa-miR-125b-5p EMX1 0.00744496603712985 0.994576506820994 -0.455482131945542 0.533804388920932 mirMAP -0.402456748793671 0.0132138852244315 NA NA NA hsa-miR-1275 ENKUR -0.092958576443477 0.78712696322568 0.205937072519026 0.590708553324994 MirTarget -0.151589201467873 0.0100250108401948 NA NA NA hsa-miR-125b-5p EPHA10 0.00744496603712985 0.994576506820994 -0.351054385257681 0.515163649646145 mirMAP;miRNATAP -0.126586437138263 0.0273725247764821 NA NA NA hsa-miR-222-3p ERCC4 0.067264556454159 0.934147523407911 -0.120823850556508 0.782338741318961 MirTarget -0.156249345016262 2.42466614631204e-06 NA NA NA hsa-miR-222-3p ESR1 0.067264556454159 0.934147523407911 -0.187642984473505 0.630198198862243 miRNAWalker2_validate;miRNATAP -0.653855353070933 5.08513663264298e-08 NA NA NA hsa-miR-125b-5p ESRRA 0.00744496603712985 0.994576506820994 0.102457967641109 0.916583346261715 MirTarget;miRNATAP -0.108260469620112 0.000578635126092938 NA NA NA hsa-miR-10a-5p ETS1 -0.103091346403293 0.963361104257071 -0.338130978794208 0.697834510666079 miRNAWalker2_validate -0.301811592107525 8.99023802645298e-07 NA NA NA hsa-miR-1275 ETS1 -0.092958576443477 0.78712696322568 -0.338130978794208 0.697834510666079 MirTarget -0.159486762599976 9.20187381412234e-05 NA NA NA hsa-miR-222-3p ETS1 0.067264556454159 0.934147523407911 -0.338130978794208 0.697834510666079 miRNAWalker2_validate;miRTarBase;miRNATAP -0.376881064613996 8.73604606022674e-08 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-222-3p EVI2A 0.067264556454159 0.934147523407911 0.0269494519669538 0.943828446788068 MirTarget -0.43379839679028 3.28498205708139e-05 NA NA NA hsa-miR-1275 F2RL3 -0.092958576443477 0.78712696322568 -0.243388124335004 0.496865429101061 MirTarget -0.140097431454093 0.00158506721095118 NA NA NA hsa-miR-320c FADS2 -0.634817265516566 0.0229406911033521 -0.032035598749963 0.967897083799429 mirMAP -0.194059865513172 0.0299372794882048 NA NA NA hsa-miR-143-3p FAM111A -0.0402404826858778 0.987317207979986 0.00849083540701479 0.990954131964956 MirTarget -0.179788695698187 2.27617401360246e-05 NA NA NA hsa-miR-320c FAM126A -0.634817265516566 0.0229406911033521 0.121186914681537 0.796934675343486 miRanda;mirMAP -0.131987244734485 0.0364286664940313 NA NA NA hsa-miR-10a-5p FAM127A -0.103091346403293 0.963361104257071 0.137824337394846 0.85076068444433 mirMAP -0.27840752848637 0.000531860551137059 NA NA NA hsa-miR-10a-5p FAM127C -0.103091346403293 0.963361104257071 0.151442782558516 0.693941437928098 mirMAP -0.417359560269693 4.61987248715131e-10 NA NA NA hsa-miR-320c FAM129A -0.634817265516566 0.0229406911033521 -0.146368299751187 0.800185448762598 miRanda -0.15118656981058 0.0450328305437204 NA NA NA hsa-miR-1275 FAM131B -0.092958576443477 0.78712696322568 0.0721527783366398 0.888740782012446 MirTarget -0.194599612338112 0.0213805108430321 NA NA NA hsa-miR-320c FAM131B -0.634817265516566 0.0229406911033521 0.0721527783366398 0.888740782012446 MirTarget;miRanda -0.230174562843332 0.0303872503542704 NA NA NA hsa-miR-320c FAM155A -0.634817265516566 0.0229406911033521 0.281217752995477 0.395544855328477 miRanda -0.181715613373358 0.0394417005279862 NA NA NA hsa-miR-10a-5p FAM168A -0.103091346403293 0.963361104257071 -0.36268955309591 0.38357792764847 miRNAWalker2_validate -0.170281018846555 0.000891637407688194 NA NA NA hsa-miR-222-3p FAM168A 0.067264556454159 0.934147523407911 -0.36268955309591 0.38357792764847 mirMAP -0.300296161204278 2.25510992840303e-07 NA NA NA hsa-miR-10a-5p FAM171A2 -0.103091346403293 0.963361104257071 0.152115895270702 0.581438291436169 mirMAP -0.320933083743322 8.20398470783511e-05 NA NA NA hsa-miR-1275 FAM19A5 -0.092958576443477 0.78712696322568 0.123067511631963 0.747363058993588 mirMAP -0.138524449641638 0.0190482592149124 NA NA NA hsa-miR-320c FAM19A5 -0.634817265516566 0.0229406911033521 0.123067511631963 0.747363058993588 miRanda -0.207757206228629 0.0050084463446088 NA NA NA hsa-miR-1275 FAM26E -0.092958576443477 0.78712696322568 0.202920867891809 0.573258012806895 MirTarget -0.261159772610433 9.80068898227242e-06 NA NA NA hsa-miR-320c FAM26E -0.634817265516566 0.0229406911033521 0.202920867891809 0.573258012806895 mirMAP -0.157375361532741 0.0371135735010028 NA NA NA hsa-miR-125b-5p FAM46A 0.00744496603712985 0.994576506820994 -0.20464034892034 0.76389836788557 miRNATAP -0.109136801955327 0.0309353719949527 NA NA NA hsa-miR-143-3p FAM60A -0.0402404826858778 0.987317207979986 -0.0958808735583458 0.923138746268592 MirTarget;miRNATAP -0.140878947042212 0.00110616849001332 NA NA NA hsa-miR-143-3p FAR1 -0.0402404826858778 0.987317207979986 -0.0217043918444988 0.980180235071728 MirTarget;miRNATAP -0.143054103439614 7.64016524602087e-05 NA NA NA hsa-miR-100-5p FARSB -0.0835426508859793 0.958163253942357 -0.0374779888360637 0.96684263378645 miRNAWalker2_validate -0.135046042912781 4.0093019523354e-06 NA NA NA hsa-miR-320c FAT3 -0.634817265516566 0.0229406911033521 -0.0251832380134167 0.950010561878046 mirMAP -0.257525609830722 0.00450240775625496 NA NA NA hsa-miR-1275 FBN1 -0.092958576443477 0.78712696322568 -0.00916626398799991 0.99235181199992 PITA -0.296337578813446 9.92216133329476e-06 NA NA NA hsa-miR-1275 FBXL16 -0.092958576443477 0.78712696322568 -0.149841428254251 0.749836520554367 PITA;mirMAP -0.168180620214005 0.0253080726976603 NA NA NA hsa-miR-320c FBXO32 -0.634817265516566 0.0229406911033521 -0.0834378524065134 0.892972564723023 mirMAP -0.116546862424456 0.024691750273429 NA NA NA hsa-miR-222-3p FERMT2 0.067264556454159 0.934147523407911 0.0367751841543944 0.955220388958826 MirTarget;miRNATAP -0.785597327060959 1.40049082824739e-17 NA NA NA hsa-miR-320c FERMT2 -0.634817265516566 0.0229406911033521 0.0367751841543944 0.955220388958826 miRanda -0.196085438285503 0.00568795759979098 NA NA NA hsa-miR-1275 FERMT3 -0.092958576443477 0.78712696322568 -0.100808452586428 0.870923512181998 MirTarget -0.13351706047446 0.0100736159907721 NA NA NA hsa-miR-143-3p FGD4 -0.0402404826858778 0.987317207979986 -0.0368876386282802 0.956077240465649 MirTarget -0.197677969292081 6.96147872710713e-06 NA NA NA hsa-miR-1275 FGF1 -0.092958576443477 0.78712696322568 0.390021692801821 0.200431948207082 MirTarget -0.234426625474762 0.00025742532980694 NA NA NA hsa-miR-320c FGF1 -0.634817265516566 0.0229406911033521 0.390021692801821 0.200431948207082 miRanda -0.174178464889134 0.0323587796193374 NA NA NA hsa-miR-10a-5p FGF11 -0.103091346403293 0.963361104257071 0.204232210542744 0.410486875279382 mirMAP -0.183447717169761 0.00781424110500811 NA NA NA hsa-let-7a-3p FGF13 -0.0729953134802095 0.920987206070783 0.300208050188789 0.384721829732031 MirTarget;miRNATAP -0.413074100574929 0.00107885043966615 NA NA NA hsa-let-7b-3p FGF13 -0.0901460261255016 0.902176614355506 0.300208050188789 0.384721829732031 MirTarget;miRNATAP -0.335741179047486 0.0351037356277134 NA NA NA hsa-let-7f-1-3p FGF13 -0.111974492904027 0.817828599777684 0.300208050188789 0.384721829732031 MirTarget -0.581948669375274 0.000736238594408478 NA NA NA hsa-let-7g-3p FGF13 -0.0113794947575885 0.985270887582985 0.300208050188789 0.384721829732031 miRNATAP -0.33696694896657 0.000531004193754099 NA NA NA hsa-miR-141-3p FGF13 0.0210503739430692 0.98673570042861 0.300208050188789 0.384721829732031 TargetScan -0.417159688034008 1.38167745575151e-05 NA NA NA hsa-miR-142-5p FGF13 0.176815469040626 0.829644258081575 0.300208050188789 0.384721829732031 PITA -0.292382680960941 0.00456041296807669 NA NA NA hsa-miR-200a-5p FGF13 -0.0789456056445115 0.956935767371258 0.300208050188789 0.384721829732031 MirTarget;miRNATAP -0.564495834356228 3.51651879637505e-08 NA NA NA hsa-miR-200b-5p FGF13 -0.0843746780836296 0.921517885377118 0.300208050188789 0.384721829732031 MirTarget -0.460602297876751 6.93130489630411e-06 NA NA NA hsa-miR-31-3p FGF13 -0.291292090541954 0.581336720001078 0.300208050188789 0.384721829732031 miRNATAP -0.174024666919551 0.000702309408246688 NA NA NA hsa-miR-338-5p FGF13 0.24542865845177 0.534074485811734 0.300208050188789 0.384721829732031 PITA -0.36774029417946 7.03795092005192e-06 NA NA NA hsa-miR-340-5p FGF13 -0.00389419024830762 0.994564832808438 0.300208050188789 0.384721829732031 MirTarget -0.270676295403619 0.0444566133628476 NA NA NA hsa-miR-429 FGF13 -0.238887571847831 0.835358736540541 0.300208050188789 0.384721829732031 miRNATAP -0.355487712048412 7.40384400340134e-05 NA NA NA hsa-miR-486-5p FGF13 -0.16110372776006 0.851150395551866 0.300208050188789 0.384721829732031 MirTarget;PITA;miRanda;miRNATAP -0.326993602223932 1.70539866789723e-05 NA NA NA hsa-miR-511-5p FGF13 0.448761097177155 0.220709329326234 0.300208050188789 0.384721829732031 MirTarget -0.248337216980494 0.0131535515647088 NA NA NA hsa-miR-590-3p FGF13 0.0829620326684548 0.810708708264937 0.300208050188789 0.384721829732031 miRanda -0.459516353830251 9.69022571347246e-07 NA NA NA hsa-miR-7-1-3p FGF13 -0.126737838158129 0.846416009084243 0.300208050188789 0.384721829732031 MirTarget;mirMAP -0.56794497333139 2.1848177002488e-07 NA NA NA hsa-miR-222-3p FGF2 0.067264556454159 0.934147523407911 -0.0855714615664658 0.827451535502983 mirMAP -0.553734986991286 1.13582430859507e-06 NA NA NA hsa-miR-10a-5p FGFR1 -0.103091346403293 0.963361104257071 0.00991014103214205 0.989102083920515 miRNAWalker2_validate -0.427574241021871 5.41836198534693e-08 21738581 Predicted target mRNAs FGFR1 miR-10 and MLH1 miR-155 were found downregulated pancreatic cancer hsa-miR-100-5p FGFR3 -0.0835426508859793 0.958163253942357 -0.164098967351921 0.81531740443876 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.162436139908574 0.0291336095745565 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-10a-5p FHL3 -0.103091346403293 0.963361104257071 0.0694011950066526 0.902938032705685 miRNATAP -0.221705135675931 0.000183621526613752 NA NA NA hsa-miR-1275 FIBIN -0.092958576443477 0.78712696322568 0.106669856363889 0.841705185997085 MirTarget -0.169444638775519 0.014577527964006 NA NA NA hsa-miR-10a-5p FIGN -0.103091346403293 0.963361104257071 -0.36332157461246 0.416952114250806 MirTarget -0.511778492534073 3.09134413273651e-06 NA NA NA hsa-miR-222-3p FIGN 0.067264556454159 0.934147523407911 -0.36332157461246 0.416952114250806 mirMAP -0.89744257585239 1.84022979798221e-13 NA NA NA hsa-miR-1275 FILIP1L -0.092958576443477 0.78712696322568 -0.0511080395996553 0.950882661580127 MirTarget -0.173508912696667 0.000162304426188253 NA NA NA hsa-miR-320c FILIP1L -0.634817265516566 0.0229406911033521 -0.0511080395996553 0.950882661580127 miRanda -0.116060785572878 0.0471825581947769 NA NA NA hsa-miR-222-3p FLNA 0.067264556454159 0.934147523407911 -0.141916122073102 0.915191575473396 miRNAWalker2_validate -0.495439269968303 5.01914444988374e-08 NA NA NA hsa-miR-10a-5p FLT1 -0.103091346403293 0.963361104257071 0.0395827384299121 0.956376518640548 miRNATAP -0.188059072473371 0.000422135661220862 NA NA NA hsa-miR-1275 FMNL1 -0.092958576443477 0.78712696322568 0.0126060066540594 0.982259427093166 MirTarget -0.197481218650339 6.18018655809752e-05 NA NA NA hsa-miR-1275 FMO2 -0.092958576443477 0.78712696322568 -0.17899180670293 0.73149747781881 MirTarget -0.269934913687181 0.0103051878155459 NA NA NA hsa-miR-320c FN1 -0.634817265516566 0.0229406911033521 0.522237681058341 0.713220110279845 miRanda -0.225996418363184 0.02932527168513 NA NA NA hsa-miR-320c FNBP1 -0.634817265516566 0.0229406911033521 0.0522427072362284 0.944206647690706 mirMAP -0.1524144887019 0.00515602459618881 NA NA NA hsa-miR-222-3p FNDC3A 0.067264556454159 0.934147523407911 -0.0457753465207578 0.960359163676088 MirTarget;miRNATAP -0.153624819997539 0.000261037786768004 NA NA NA hsa-miR-222-3p FOXP1 0.067264556454159 0.934147523407911 -0.0931863641519071 0.911238607745713 miRNATAP -0.154982693300139 0.0023044465781043 NA NA NA hsa-miR-1275 FOXP2 -0.092958576443477 0.78712696322568 -0.900531223657274 0.0908772548718619 MirTarget -0.270593263006487 0.0181589984861057 NA NA NA hsa-miR-1275 FOXP3 -0.092958576443477 0.78712696322568 -0.163790218770673 0.621313940820313 MirTarget -0.187934204475068 0.00364497242696437 NA NA NA hsa-miR-320c FRMD5 -0.634817265516566 0.0229406911033521 0.305865212646898 0.448258793244335 mirMAP -0.20290426920571 0.0281790022887648 NA NA NA hsa-miR-320c FRMD6 -0.634817265516566 0.0229406911033521 0.0992902392918382 0.862370075338059 miRanda -0.182857593228209 0.0121395760726398 NA NA NA hsa-miR-1275 FST -0.092958576443477 0.78712696322568 0.241735455604809 0.478175258443777 PITA -0.287414994448221 6.06395943237811e-05 NA NA NA hsa-miR-320c FST -0.634817265516566 0.0229406911033521 0.241735455604809 0.478175258443777 PITA;miRanda -0.190456899032672 0.0368662820141705 NA NA NA hsa-miR-1275 FSTL1 -0.092958576443477 0.78712696322568 0.115370727912274 0.914634209712387 MirTarget -0.211138981920284 4.88104562941106e-06 NA NA NA hsa-miR-320c FSTL1 -0.634817265516566 0.0229406911033521 0.115370727912274 0.914634209712387 miRanda -0.143947272146959 0.0147588035142781 NA NA NA hsa-miR-125b-5p FUT4 0.00744496603712985 0.994576506820994 -0.16982036309754 0.84954663152091 MirTarget;miRNATAP -0.225139636319819 8.58407340809433e-08 NA NA NA hsa-miR-100-5p FXN -0.0835426508859793 0.958163253942357 0.0579555168484109 0.915909461251853 miRNAWalker2_validate -0.152284337213691 2.91687756960114e-06 NA NA NA hsa-miR-320c FXYD6 -0.634817265516566 0.0229406911033521 -0.260294271177437 0.671511450333156 miRanda -0.182211667951208 0.0185467064942179 NA NA NA hsa-miR-1275 FZD1 -0.092958576443477 0.78712696322568 -0.00317574838784829 0.995919184620481 MirTarget -0.11752493679076 0.000375152206570806 NA NA NA hsa-miR-143-3p FZD3 -0.0402404826858778 0.987317207979986 -0.146453897053282 0.726966498892074 mirMAP -0.184689304004733 0.0267817770161185 NA NA NA hsa-miR-10a-5p FZD4 -0.103091346403293 0.963361104257071 -0.0138227644430522 0.981493656213288 MirTarget -0.280584207335698 6.27494988897258e-09 NA NA NA hsa-miR-100-5p FZD5 -0.0835426508859793 0.958163253942357 -0.148885365561745 0.868893984267112 MirTarget;miRNATAP -0.161373951724948 1.91022558437002e-07 NA NA NA hsa-miR-143-3p G3BP1 -0.0402404826858778 0.987317207979986 -0.0269956741053461 0.978584341536182 mirMAP -0.137316909456351 2.04579223923847e-06 NA NA NA hsa-miR-222-3p GAB1 0.067264556454159 0.934147523407911 -0.240471624750059 0.720660856459796 MirTarget;miRNATAP -0.145583600728172 0.000397142580052132 NA NA NA hsa-miR-1275 GABRP -0.092958576443477 0.78712696322568 -0.291671837296921 0.65309137576585 MirTarget -0.397174953022984 0.00490518381806601 NA NA NA hsa-miR-125b-5p GALNT7 0.00744496603712985 0.994576506820994 -0.219488625636643 0.81438475709267 MirTarget;miRNATAP -0.143896057296932 0.000141320217717333 NA NA NA hsa-miR-143-3p GALNT7 -0.0402404826858778 0.987317207979986 -0.219488625636643 0.81438475709267 MirTarget;miRNATAP -0.185065318217158 0.000599888140984961 NA NA NA hsa-miR-320c GAPT -0.634817265516566 0.0229406911033521 -0.392665017130871 0.301587542312541 miRanda -0.180948796797025 0.0491500609383116 NA NA NA hsa-miR-320c GAS7 -0.634817265516566 0.0229406911033521 -0.150751702168702 0.812433986127086 mirMAP -0.175084976384355 0.0230396886630538 NA NA NA hsa-miR-335-5p GATS -0.0823503258190108 0.879911427250447 -0.248789362815025 0.44557793035064 miRNAWalker2_validate -0.155793613752353 0.00601483368754873 NA NA NA hsa-miR-362-5p GATS 0.0641039152061174 0.904760340623955 -0.248789362815025 0.44557793035064 MirTarget -0.190035381394534 6.08703769014269e-05 NA NA NA hsa-miR-671-5p GATS 0.014664720960569 0.959843542015548 -0.248789362815025 0.44557793035064 MirTarget -0.228895873800691 0.000332936938475084 NA NA NA hsa-miR-1275 GDF6 -0.092958576443477 0.78712696322568 0.27614873321334 0.624251444855845 MirTarget;PITA;miRNATAP -0.361053686798919 0.000139291253640898 NA NA NA hsa-miR-1275 GEM -0.092958576443477 0.78712696322568 0.110435356538189 0.869839304592364 MirTarget -0.153655263219565 0.000421022648112795 NA NA NA hsa-miR-320c GFPT2 -0.634817265516566 0.0229406911033521 0.349874228365063 0.484397211424363 miRanda -0.273971650293934 0.0116124947983499 NA NA NA hsa-miR-1275 GIMAP1 -0.092958576443477 0.78712696322568 0.0168564684140906 0.954849644212416 MirTarget -0.239017977673792 1.18077947485892e-06 NA NA NA hsa-miR-1275 GIPC3 -0.092958576443477 0.78712696322568 0.161783138786081 0.563693362863176 mirMAP -0.155055251148909 1.35894394934764e-05 NA NA NA hsa-miR-320c GJB2 -0.634817265516566 0.0229406911033521 0.672232397808879 0.409313611280331 miRanda -0.101652160825839 0.041938603507361 NA NA NA hsa-miR-320c GJC1 -0.634817265516566 0.0229406911033521 0.0198845197464581 0.959138344628402 miRanda;mirMAP -0.127237916849428 0.0256895808350693 NA NA NA hsa-miR-1275 GLDN -0.092958576443477 0.78712696322568 -0.0195672955743576 0.944857716160303 MirTarget -0.124395594717538 0.0369516666636252 NA NA NA hsa-miR-320c GLI3 -0.634817265516566 0.0229406911033521 0.00544758831849257 0.989757530454735 MirTarget;PITA;miRanda -0.223461722659506 0.0138366228765346 NA NA NA hsa-miR-10a-5p GLIS2 -0.103091346403293 0.963361104257071 0.0709820321696895 0.910472961924345 mirMAP -0.370924326062437 6.23639100667069e-07 NA NA NA hsa-miR-125b-5p GLYCTK 0.00744496603712985 0.994576506820994 0.0716820283569808 0.912172517479063 MirTarget -0.118459438856976 0.00776216820643069 NA NA NA hsa-miR-125b-5p GMPPB 0.00744496603712985 0.994576506820994 0.220638909927673 0.731678100124456 mirMAP -0.106975735622125 0.00129339758400178 NA NA NA hsa-miR-10a-5p GNAL -0.103091346403293 0.963361104257071 -0.0585285016594891 0.838818073751668 miRNAWalker2_validate -0.321520436124729 0.000128484566254973 NA NA NA hsa-miR-320c GNAL -0.634817265516566 0.0229406911033521 -0.0585285016594891 0.838818073751668 mirMAP -0.161960064979921 0.0208012858127872 NA NA NA hsa-miR-1275 GNB4 -0.092958576443477 0.78712696322568 0.06915447027224 0.906615953233376 MirTarget -0.256794511297655 5.71810884593168e-08 NA NA NA hsa-miR-320c GNG11 -0.634817265516566 0.0229406911033521 0.135028294917877 0.793187934059441 miRanda -0.100922088133398 0.0356461307235163 NA NA NA hsa-miR-100-5p GNG5 -0.0835426508859793 0.958163253942357 0.0359892151406829 0.969618502116357 miRNAWalker2_validate -0.110038434475218 6.92564352999007e-06 NA NA NA hsa-miR-1254 GNG7 -0.241680582868541 0.411875416037286 -0.0805807516863948 0.797638051341537 miRNATAP -0.238000091347327 0.00103086348244356 NA NA NA hsa-miR-1275 GNG7 -0.092958576443477 0.78712696322568 -0.0805807516863948 0.797638051341537 MirTarget -0.253274883294583 8.49390362621298e-06 NA NA NA hsa-miR-141-3p GNG7 0.0210503739430692 0.98673570042861 -0.0805807516863948 0.797638051341537 MirTarget;TargetScan;miRNATAP -0.426609282329358 1.71346927725291e-08 NA NA NA hsa-miR-17-3p GNG7 -0.0899409775059787 0.942558984169841 -0.0805807516863948 0.797638051341537 mirMAP -0.457795100534964 5.89732785575079e-07 NA NA NA hsa-miR-185-3p GNG7 0.118547597880649 0.737707776347629 -0.0805807516863948 0.797638051341537 mirMAP -0.339810106428788 0.000274824912019918 NA NA NA hsa-miR-18a-3p GNG7 -0.166644537390572 0.596581925973113 -0.0805807516863948 0.797638051341537 mirMAP -0.372675848820419 8.40351957213415e-09 NA NA NA hsa-miR-18a-5p GNG7 -0.0571411929463128 0.926332009405536 -0.0805807516863948 0.797638051341537 mirMAP -0.364039130076836 2.46209226912081e-08 NA NA NA hsa-miR-18b-5p GNG7 0.0707938386472751 0.807716710948342 -0.0805807516863948 0.797638051341537 mirMAP -0.29344950018203 5.72431189988229e-06 NA NA NA hsa-miR-194-3p GNG7 -0.294094659213595 0.789561994728063 -0.0805807516863948 0.797638051341537 mirMAP -0.410204751461776 2.53365558396796e-08 NA NA NA hsa-miR-200a-3p GNG7 -0.147527970103015 0.902426235894766 -0.0805807516863948 0.797638051341537 MirTarget;miRNATAP -0.270525770292695 0.000324574104520852 NA NA NA hsa-miR-224-5p GNG7 0.00683420369444487 0.993472259403716 -0.0805807516863948 0.797638051341537 mirMAP -0.226345207198485 0.000704216351614613 NA NA NA hsa-miR-23a-3p GNG7 -0.0188223454559413 0.990631768418334 -0.0805807516863948 0.797638051341537 mirMAP -0.662403717203233 8.36604672470328e-05 NA NA NA hsa-miR-29b-3p GNG7 0.00316507717068149 0.997967593788421 -0.0805807516863948 0.797638051341537 mirMAP -0.324547807263863 0.000339788096249608 NA NA NA hsa-miR-378a-3p GNG7 -0.0448469344677127 0.967204845083264 -0.0805807516863948 0.797638051341537 mirMAP -0.276746787489566 0.00640129635092456 NA NA NA hsa-miR-500a-3p GNG7 -0.0833666863625364 0.940965178992276 -0.0805807516863948 0.797638051341537 mirMAP -0.454023927839378 4.92459324117066e-07 NA NA NA hsa-miR-532-3p GNG7 -0.00929099998528304 0.99000386705064 -0.0805807516863948 0.797638051341537 mirMAP -0.354741011856059 1.32513389076964e-05 NA NA NA hsa-miR-590-3p GNG7 0.0829620326684548 0.810708708264937 -0.0805807516863948 0.797638051341537 PITA;miRanda;mirMAP -0.321886723997531 2.03158812402469e-05 NA NA NA hsa-miR-671-5p GNG7 0.014664720960569 0.959843542015548 -0.0805807516863948 0.797638051341537 mirMAP -0.520896997203422 1.71810553995385e-08 NA NA NA hsa-miR-92a-3p GNG7 -0.0384014626227458 0.98492510670536 -0.0805807516863948 0.797638051341537 miRNAWalker2_validate -0.521267148270826 1.29668623808043e-08 NA NA NA hsa-miR-939-5p GNG7 -0.264147695339663 0.260324874483214 -0.0805807516863948 0.797638051341537 mirMAP -0.360632599824294 5.47831469766152e-06 NA NA NA hsa-miR-940 GNG7 -0.0800854013678642 0.833581451468191 -0.0805807516863948 0.797638051341537 MirTarget -0.325319226450819 4.03321988919025e-07 NA NA NA hsa-miR-96-5p GNG7 0.0812346609576227 0.885285229701925 -0.0805807516863948 0.797638051341537 mirMAP -0.217584414157617 0.00558972226725726 NA NA NA hsa-miR-143-3p GNL3 -0.0402404826858778 0.987317207979986 -0.0484154187390935 0.960476238984227 MirTarget -0.162512931919564 1.9527442341757e-05 NA NA NA hsa-miR-222-3p GPM6A 0.067264556454159 0.934147523407911 -0.450930765428006 0.507127765820208 miRNATAP -1.65979072800723 1.10415740287768e-13 NA NA NA hsa-miR-320c GPM6A -0.634817265516566 0.0229406911033521 -0.450930765428006 0.507127765820208 miRanda -0.353880984677509 0.0368217725627323 NA NA NA hsa-miR-320c GPM6B -0.634817265516566 0.0229406911033521 0.345007999039233 0.246360303620129 PITA;miRanda -0.196503184982696 0.00937437564070448 NA NA NA hsa-miR-320c GPNMB -0.634817265516566 0.0229406911033521 0.216765596097871 0.808838232790139 MirTarget;miRanda -0.212318208554562 0.0299028879248413 NA NA NA hsa-miR-1275 GPR173 -0.092958576443477 0.78712696322568 0.166342686149379 0.60727804668281 MirTarget -0.147606340356685 0.00584209548211667 NA NA NA hsa-miR-320c GPR183 -0.634817265516566 0.0229406911033521 -0.0315456318245784 0.941156492827079 miRanda -0.172779085339888 0.0217309474441291 NA NA NA hsa-miR-10a-5p GPR63 -0.103091346403293 0.963361104257071 0.136505302966901 0.615685289919816 miRNAWalker2_validate -0.249085805774812 0.00327006281869021 NA NA NA hsa-miR-320c GPRASP1 -0.634817265516566 0.0229406911033521 0.00170670708725451 0.996175588824486 MirTarget;miRanda -0.128135272732306 0.0442305395268679 NA NA NA hsa-miR-125b-5p GPRIN1 0.00744496603712985 0.994576506820994 -0.10237473420389 0.828082059647831 miRNAWalker2_validate -0.131068660456939 0.00664008357706393 NA NA NA hsa-miR-1275 GPSM1 -0.092958576443477 0.78712696322568 0.0334984182313689 0.93786824484748 MirTarget -0.157449752177381 0.00257444529433483 NA NA NA hsa-miR-320c GRASP -0.634817265516566 0.0229406911033521 -0.0220745446721828 0.943412702712398 miRanda;miRNATAP -0.125796143663492 0.00700165556134475 NA NA NA hsa-miR-320c GREB1L -0.634817265516566 0.0229406911033521 0.218753367470694 0.7575875858157 mirMAP -0.298141949453148 0.0481993024475632 NA NA NA hsa-miR-1275 GREM2 -0.092958576443477 0.78712696322568 -0.893700405271578 0.0988955469259783 MirTarget -0.353485631106169 0.00211926131676748 NA NA NA hsa-miR-143-3p GRHL2 -0.0402404826858778 0.987317207979986 -0.209073940299282 0.80437944888155 MirTarget;miRNATAP -0.173562673171464 2.76838643111078e-05 NA NA NA hsa-miR-1275 GRIN1 -0.092958576443477 0.78712696322568 0.255004124231889 0.522639180604877 PITA -0.240521659619254 0.00437577975849337 NA NA NA hsa-miR-320c GRIN2A -0.634817265516566 0.0229406911033521 -0.257585427554986 0.682026324759459 PITA -0.257688210843682 0.0208866222932785 NA NA NA hsa-miR-10a-5p GRIN3A -0.103091346403293 0.963361104257071 0.242519078792084 0.284113499421042 miRNATAP -0.133023614750676 0.0489359611012108 NA NA NA hsa-miR-1275 GRIP2 -0.092958576443477 0.78712696322568 -0.138412509393659 0.735669375530024 MirTarget -0.249836612399391 0.00172707524372845 NA NA NA hsa-miR-125b-5p GRSF1 0.00744496603712985 0.994576506820994 -0.0376094477236517 0.969560311809781 MirTarget;miRNATAP -0.10182023231714 6.28764526235683e-06 NA NA NA hsa-miR-320c GSTM5 -0.634817265516566 0.0229406911033521 -0.287360217773708 0.39379210050777 mirMAP -0.222300870652656 0.0130509215455596 NA NA NA hsa-miR-222-3p GTF3C4 0.067264556454159 0.934147523407911 -0.0880562210263029 0.886996668057788 mirMAP -0.11886857378492 0.00116687832986137 NA NA NA hsa-miR-222-3p GUCY1A2 0.067264556454159 0.934147523407911 0.302129490525276 0.457739338446256 MirTarget -0.381079950158713 0.00147566589887804 NA NA NA hsa-miR-320c GUCY1B3 -0.634817265516566 0.0229406911033521 0.0918561309934396 0.851711363486582 miRanda -0.180992912844363 0.00566510518435908 NA NA NA hsa-miR-143-3p GXYLT1 -0.0402404826858778 0.987317207979986 -0.079285799683781 0.902501017353893 miRNATAP -0.122562124801352 0.000230474005436716 NA NA NA hsa-miR-1275 GYPC -0.092958576443477 0.78712696322568 0.0920104744467274 0.839455159434571 MirTarget -0.250643948517112 6.62935164259854e-08 NA NA NA hsa-miR-100-5p H2AFY -0.0835426508859793 0.958163253942357 0.0627261589964636 0.957095287330129 miRNAWalker2_validate -0.113654004510176 5.18200730498598e-06 NA NA NA hsa-miR-125b-5p HAPLN1 0.00744496603712985 0.994576506820994 0.346019483372477 0.270315621038928 MirTarget;miRNATAP -0.284248970560987 0.000468171274375918 NA NA NA hsa-miR-1275 HAPLN4 -0.092958576443477 0.78712696322568 0.318510265158648 0.453706467119546 MirTarget -0.181697809682795 0.00252547416170237 NA NA NA hsa-miR-125b-5p HBS1L 0.00744496603712985 0.994576506820994 -0.0264816119251963 0.972856760924202 miRNAWalker2_validate -0.101007816582052 3.01796515038089e-07 NA NA NA hsa-miR-320c HDAC9 -0.634817265516566 0.0229406911033521 0.371796653401914 0.343172571084292 miRanda -0.202967625717941 0.0160484131488789 NA NA NA hsa-miR-222-3p HECTD2 0.067264556454159 0.934147523407911 0.0977610227370707 0.739818214321106 miRNATAP -0.329290006397629 6.44801942248714e-06 NA NA NA hsa-miR-1275 HECW2 -0.092958576443477 0.78712696322568 0.0216678023277661 0.950278699966206 MirTarget;PITA -0.166628916639369 0.00016300543334291 NA NA NA hsa-miR-143-3p HEMK1 -0.0402404826858778 0.987317207979986 -0.00832755300985788 0.989429898007414 mirMAP -0.129572993307993 0.000810762926188853 NA NA NA hsa-miR-1275 HEYL -0.092958576443477 0.78712696322568 0.0959503542582358 0.869884589578854 MirTarget -0.120514335018611 0.00228942175559936 NA NA NA hsa-miR-1275 HHIPL1 -0.092958576443477 0.78712696322568 0.109432304547916 0.721583818136281 mirMAP -0.221442738358422 0.000181896576710705 NA NA NA hsa-miR-320c HHIPL1 -0.634817265516566 0.0229406911033521 0.109432304547916 0.721583818136281 miRanda -0.187191596990368 0.0125510903363111 NA NA NA hsa-miR-320c HIC1 -0.634817265516566 0.0229406911033521 0.00988944745239051 0.981454142032399 PITA;miRanda -0.130799977225496 0.0193865413383096 NA NA NA hsa-miR-222-3p HIPK1 0.067264556454159 0.934147523407911 -0.116695920922028 0.894426416588083 MirTarget;miRNATAP -0.114462312630848 0.00094985408001144 NA NA NA hsa-miR-222-3p HIPK3 0.067264556454159 0.934147523407911 -0.289985711220562 0.679058077827102 MirTarget -0.331947911822782 2.85120344963117e-11 NA NA NA hsa-miR-100-5p HIST2H2AA3 -0.0835426508859793 0.958163253942357 0.132074270569623 0.807826233816314 miRNAWalker2_validate -0.190815672654036 0.000910640547517879 NA NA NA hsa-miR-125b-5p HIST2H3C 0.00744496603712985 0.994576506820994 0.0199023631990336 0.969477613643019 mirMAP -0.155730139324113 0.0417570586585386 NA NA NA hsa-miR-125b-5p HK2 0.00744496603712985 0.994576506820994 -0.0258910838628523 0.980154085711379 miRNAWalker2_validate;miRTarBase -0.25034276476237 3.43308589698237e-08 NA NA NA hsa-miR-143-3p HK2 -0.0402404826858778 0.987317207979986 -0.0258910838628523 0.980154085711379 miRNAWalker2_validate;miRTarBase -0.285204566841522 1.27393913771806e-05 22691140;25322940;27574783;23376635;26269764;24033605 MicroRNA 143 down regulates Hexokinase 2 in colon cancer cells; Here we report the identification of Hexokinase 2 HK2 as a direct target of miR-143; We have identified and validated HK2 as a miR-143 target; Furthermore our results indicate that miR-143 mediated down-regulation of HK2 affects glucose metabolism in colon cancer cells;Furthermore knockdown of ATG2B and hexokinase 2 a key enzyme in glycolysis and another target of miR-143 co-ordinated to inhibit the proliferation of H1299 cells;We previously identified hexokinase 2 the major glycolytic enzyme as a target gene of miR-143 in TNBC;We show that miR-143 is significantly down-regulated in glioma tissues and glioblastoma stem-like cells GSLCs while miR-143 over-expression inhibits glycolysis by directly targeting hexokinase 2 and promotes differentiation of GSLCs;MicroRNA 143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer; Furthermore we identified hexokinase 2 HK2 a metabolic enzyme that executes the first step of aerobic glycolysis as a target of miR-143 in prostate cancer; Knockdown of HK2 recapitulated the effects of miR-143 and accompanied with decreased glucose metabolism;Luciferase reporter assays showed that both miR-143 and miR-145 directly regulated HK2 ;;;differentiation;; colon cancer;lung squamous cell cancer;breast cancer;glioblastoma;prostate cancer;kidney renal cell cancer hsa-miR-143-3p HMBS -0.0402404826858778 0.987317207979986 0.0400734798501787 0.956674667037211 MirTarget -0.200585518435304 3.87647272646307e-06 NA NA NA hsa-miR-125b-5p HMGA1 0.00744496603712985 0.994576506820994 0.0802699303279102 0.948232529146006 miRNAWalker2_validate;miRTarBase -0.182441639086756 1.20378381124426e-06 NA NA NA hsa-miR-143-3p HMGA1 -0.0402404826858778 0.987317207979986 0.0802699303279102 0.948232529146006 miRNATAP -0.176508988706706 0.00113311465917804 NA NA NA hsa-miR-100-5p HMGN1 -0.0835426508859793 0.958163253942357 0.00550101726987151 0.995737745279535 miRNAWalker2_validate -0.134002266171661 3.37394474913709e-08 NA NA NA hsa-miR-125b-5p HMGN1 0.00744496603712985 0.994576506820994 0.00550101726987151 0.995737745279535 miRNAWalker2_validate -0.102714209565934 2.36418522805465e-05 NA NA NA hsa-miR-1275 HPGDS -0.092958576443477 0.78712696322568 0.224237885880106 0.586239973214633 MirTarget -0.221794462791637 0.00389820693652587 NA NA NA hsa-miR-143-3p HRAS -0.0402404826858778 0.987317207979986 0.169641284274943 0.802709147077292 miRNAWalker2_validate;miRTarBase -0.105836456400221 0.0241976769485079 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-320c HSD17B6 -0.634817265516566 0.0229406911033521 0.26190662808378 0.391492297237439 miRanda -0.16020280228818 0.0235141329065086 NA NA NA hsa-miR-125b-5p HSPA1B 0.00744496603712985 0.994576506820994 0.229947481665574 0.822772162485014 miRNAWalker2_validate -0.115387716489265 0.0124874900894923 NA NA NA hsa-miR-320c HSPB6 -0.634817265516566 0.0229406911033521 -0.117624643042072 0.847608730896084 miRNATAP -0.250984402195028 0.0449184421487008 NA NA NA hsa-miR-125b-5p HSPD1 0.00744496603712985 0.994576506820994 -0.106750709793946 0.937184555427006 miRNAWalker2_validate -0.125008345559874 0.000266674917690605 NA NA NA hsa-miR-1275 HTR3A -0.092958576443477 0.78712696322568 -0.563046417483932 0.372540959975674 MirTarget -0.380382352624662 0.000192557210874946 NA NA NA hsa-miR-100-5p IARS -0.0835426508859793 0.958163253942357 0.0134700654651523 0.989829379099037 miRNAWalker2_validate -0.1079801781717 2.15728475422482e-05 NA NA NA hsa-miR-125b-5p IER3IP1 0.00744496603712985 0.994576506820994 -0.000584410503369881 0.99938472691857 MirTarget -0.12187982626017 1.65565144821962e-05 NA NA NA hsa-miR-10a-5p IFFO2 -0.103091346403293 0.963361104257071 -0.0719074171018095 0.91994840996442 MirTarget -0.124129443078521 0.0125403296156721 NA NA NA hsa-miR-10a-5p IGDCC4 -0.103091346403293 0.963361104257071 -0.255721224373197 0.488201911487145 MirTarget -0.253702609858297 0.00139483438744078 NA NA NA hsa-miR-1275 IGF1 -0.092958576443477 0.78712696322568 -0.225137597142746 0.630735582920472 MirTarget;PITA -0.38101781548121 5.45983739511041e-05 NA NA NA hsa-miR-1275 IGF2BP3 -0.092958576443477 0.78712696322568 0.167091320346159 0.781147963839098 MirTarget -0.54497305398784 4.68090742877034e-06 NA NA NA hsa-miR-320c IGF2BP3 -0.634817265516566 0.0229406911033521 0.167091320346159 0.781147963839098 MirTarget;PITA;miRanda;miRNATAP -0.322808001973388 0.0341099374916499 NA NA NA hsa-miR-1275 IGFBP5 -0.092958576443477 0.78712696322568 -0.05753412696476 0.961346906031511 MirTarget;mirMAP -0.221015878852432 0.000817292075275023 NA NA NA hsa-miR-10a-5p IGLON5 -0.103091346403293 0.963361104257071 0.755733263971754 0.0589888217208155 mirMAP -0.358331802692514 0.00132457240951072 NA NA NA hsa-miR-10a-5p IGSF1 -0.103091346403293 0.963361104257071 0.639429828390335 0.26329963186534 miRNAWalker2_validate -0.683195036665249 6.56425726019707e-06 NA NA NA hsa-miR-10a-5p IGSF9B -0.103091346403293 0.963361104257071 -0.361455113715345 0.298259503291803 miRNAWalker2_validate -0.278244813261115 0.014041514108282 NA NA NA hsa-miR-1275 IL12RB2 -0.092958576443477 0.78712696322568 0.229782829569653 0.521380607515905 MirTarget -0.199483074951665 0.00161480424701706 NA NA NA hsa-miR-1275 IL17REL -0.092958576443477 0.78712696322568 -0.0687079614258193 0.915487092249564 MirTarget;mirMAP -0.358464363739321 0.000112123037459725 NA NA NA hsa-miR-222-3p ILK 0.067264556454159 0.934147523407911 0.125417743226078 0.898467935826931 miRNAWalker2_validate -0.102315514691894 0.000653119252387204 NA NA NA hsa-miR-1275 INA -0.092958576443477 0.78712696322568 0.134648634000219 0.796764530619932 MirTarget -0.348636578599963 0.000111627606485773 NA NA NA hsa-miR-222-3p INA 0.067264556454159 0.934147523407911 0.134648634000219 0.796764530619932 MirTarget -0.691253174965981 1.12568348075177e-05 NA NA NA hsa-miR-320c INA -0.634817265516566 0.0229406911033521 0.134648634000219 0.796764530619932 MirTarget;miRanda;miRNATAP -0.34308023059329 0.00264468053149891 NA NA NA hsa-miR-10a-5p INHBB -0.103091346403293 0.963361104257071 0.531866162994754 0.292987167106386 miRNATAP -0.227087003543335 0.0418420164816766 NA NA NA hsa-miR-1275 INSM1 -0.092958576443477 0.78712696322568 0.426424162329409 0.497717759636959 MirTarget -0.355951555701532 0.00477307015785015 NA NA NA hsa-miR-10a-5p IPCEF1 -0.103091346403293 0.963361104257071 -0.425552167521078 0.13282465038936 miRNAWalker2_validate -0.197901663245111 0.0266646067449642 NA NA NA hsa-miR-125b-5p IPMK 0.00744496603712985 0.994576506820994 -0.18338471452262 0.551807387108027 miRNATAP -0.129163615016846 0.00332709806423112 NA NA NA hsa-miR-320c IQCA1 -0.634817265516566 0.0229406911033521 0.206102059243267 0.620622741182922 miRanda -0.175364033516512 0.0345633186127595 NA NA NA hsa-miR-1275 IQSEC3 -0.092958576443477 0.78712696322568 0.382871323478213 0.281580548799847 mirMAP -0.202879948186012 0.00279534808355211 NA NA NA hsa-miR-222-3p ITGB3 0.067264556454159 0.934147523407911 -0.207306852635047 0.627019348924388 MirTarget -0.688035014679129 1.37757019532422e-13 NA NA NA hsa-miR-320c ITGB3 -0.634817265516566 0.0229406911033521 -0.207306852635047 0.627019348924388 miRanda -0.145904777072755 0.0385369616452125 NA NA NA hsa-miR-222-3p JAM3 0.067264556454159 0.934147523407911 0.0806688441050785 0.889719414937161 mirMAP -0.540133405748077 6.18798734116989e-16 NA NA NA hsa-miR-320c JAM3 -0.634817265516566 0.0229406911033521 0.0806688441050785 0.889719414937161 miRanda -0.147538067755972 0.0038223599458716 NA NA NA hsa-miR-1275 JAZF1 -0.092958576443477 0.78712696322568 0.156921755877018 0.701870471373564 MirTarget;PITA -0.190532028275558 8.95119586046846e-07 NA NA NA hsa-miR-320c JAZF1 -0.634817265516566 0.0229406911033521 0.156921755877018 0.701870471373564 miRanda -0.136348328193107 0.00602062858407732 NA NA NA hsa-miR-222-3p JMY 0.067264556454159 0.934147523407911 -0.173815034709364 0.784028044511732 MirTarget -0.171969364147807 1.54963537777615e-05 NA NA NA hsa-miR-100-5p JPH1 -0.0835426508859793 0.958163253942357 -0.177665630354586 0.805764578711574 miRNAWalker2_validate -0.130647886893718 0.00214785048362306 NA NA NA hsa-miR-320c JPH2 -0.634817265516566 0.0229406911033521 -0.0544155956451586 0.899605549497172 miRanda -0.199626935302504 0.0347783377533976 NA NA NA hsa-miR-1275 JPH4 -0.092958576443477 0.78712696322568 -0.162512925315909 0.693992827906956 MirTarget -0.25896330240541 4.41414896559081e-05 NA NA NA hsa-miR-1275 KANK2 -0.092958576443477 0.78712696322568 -0.0278179066009416 0.973545141094669 MirTarget -0.144911019000154 3.11507774541886e-05 NA NA NA hsa-miR-125b-5p KCNK10 0.00744496603712985 0.994576506820994 0.19647019676769 0.589058769690783 MirTarget;miRNATAP -0.246249177159834 0.012273947921193 NA NA NA hsa-miR-222-3p KCNK2 0.067264556454159 0.934147523407911 0.228058745485938 0.725333480318686 MirTarget -0.818228092415123 4.72641506155196e-07 NA NA NA hsa-miR-1275 KCNK3 -0.092958576443477 0.78712696322568 -0.198940732287261 0.666203460341965 MirTarget -0.464564550945622 2.48129988381002e-07 NA NA NA hsa-miR-1275 KCNMA1 -0.092958576443477 0.78712696322568 -0.310593149125477 0.601458027270815 MirTarget -0.421387112204377 5.16318014373393e-06 NA NA NA hsa-miR-222-3p KCNQ3 0.067264556454159 0.934147523407911 0.429666274577183 0.387936741084845 MirTarget -0.26952147785458 0.0317789420464746 NA NA NA hsa-miR-1275 KCNQ4 -0.092958576443477 0.78712696322568 0.037902080220472 0.924447739434378 mirMAP -0.228394858221717 0.00605291535214676 NA NA NA hsa-miR-1275 KCTD12 -0.092958576443477 0.78712696322568 0.0687534582320612 0.932470952802609 MirTarget -0.289322319166018 1.35040146651552e-06 NA NA NA hsa-miR-1275 KCTD15 -0.092958576443477 0.78712696322568 -0.278038853382079 0.624947926156148 mirMAP -0.198997595925447 4.64218313074822e-05 NA NA NA hsa-miR-125b-5p KCTD5 0.00744496603712985 0.994576506820994 0.0446748463066919 0.958809148487563 miRNATAP -0.103208433147503 7.80152738891327e-06 NA NA NA hsa-miR-222-3p KIAA0430 0.067264556454159 0.934147523407911 -0.113295436775091 0.896767440338371 MirTarget;miRNATAP -0.173077260253623 4.04136899491423e-08 NA NA NA hsa-miR-222-3p KIAA0586 0.067264556454159 0.934147523407911 -0.0595715218890405 0.912125069461434 MirTarget -0.147934696097125 0.000135760821884094 NA NA NA hsa-miR-10a-5p KIAA1462 -0.103091346403293 0.963361104257071 0.0721095182648828 0.910128097484446 MirTarget -0.491667860472311 1.5843781946941e-10 NA NA NA hsa-miR-10a-5p KIAA1614 -0.103091346403293 0.963361104257071 0.173495396372283 0.412391663681536 mirMAP -0.272522294058977 2.5245607071826e-05 NA NA NA hsa-miR-1275 KIAA1614 -0.092958576443477 0.78712696322568 0.173495396372283 0.412391663681536 mirMAP -0.105177319271054 0.0146500101987408 NA NA NA hsa-miR-1275 KIAA1644 -0.092958576443477 0.78712696322568 -0.188840470196022 0.61838497412173 MirTarget -0.363582428234325 1.78498658283121e-06 NA NA NA hsa-miR-320c KIAA1644 -0.634817265516566 0.0229406911033521 -0.188840470196022 0.61838497412173 mirMAP -0.257380519880872 0.00820473325786646 NA NA NA hsa-let-7a-3p KIAA2022 -0.0729953134802095 0.920987206070783 -0.291832207363993 0.59570478921045 MirTarget;mirMAP -1.0134723822977 1.16098383913344e-11 NA NA NA hsa-let-7a-5p KIAA2022 -0.119216092508445 0.953139102948212 -0.291832207363993 0.59570478921045 TargetScan -1.02655710254661 5.32399768647867e-05 NA NA NA hsa-let-7b-3p KIAA2022 -0.0901460261255016 0.902176614355506 -0.291832207363993 0.59570478921045 MirTarget;mirMAP -0.813625778207578 2.49419954368034e-05 NA NA NA hsa-let-7f-1-3p KIAA2022 -0.111974492904027 0.817828599777684 -0.291832207363993 0.59570478921045 MirTarget;mirMAP -1.60678953253998 8.93968656750631e-16 NA NA NA hsa-miR-101-5p KIAA2022 -0.178674972184377 0.584353149099238 -0.291832207363993 0.59570478921045 mirMAP -0.260885817990805 0.0289422718945973 NA NA NA hsa-miR-103a-3p KIAA2022 -0.0950237190031995 0.961005442872667 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -1.16567427963632 7.20607436526203e-09 NA NA NA hsa-miR-107 KIAA2022 -0.0692564691973274 0.964215554949362 -0.291832207363993 0.59570478921045 MirTarget;PITA;miRNATAP -1.43269912696234 3.94857431812619e-10 NA NA NA hsa-miR-126-5p KIAA2022 0.15488643986308 0.866941960712436 -0.291832207363993 0.59570478921045 mirMAP -0.534703962259741 0.00312341624069677 NA NA NA hsa-miR-1262 KIAA2022 -0.0365609639451277 0.873061890079863 -0.291832207363993 0.59570478921045 PITA;miRNATAP -0.433692164541843 0.00104273599941812 NA NA NA hsa-miR-130b-5p KIAA2022 -0.167507564745282 0.70882286970573 -0.291832207363993 0.59570478921045 miRNATAP -1.27941389801271 1.01221339888555e-25 NA NA NA hsa-miR-136-5p KIAA2022 0.15252965024613 0.758258613050847 -0.291832207363993 0.59570478921045 mirMAP -0.356705282258484 0.00498584429863334 NA NA NA hsa-miR-141-3p KIAA2022 0.0210503739430692 0.98673570042861 -0.291832207363993 0.59570478921045 MirTarget;TargetScan -1.19278050906124 4.64964633303486e-30 NA NA NA hsa-miR-141-5p KIAA2022 0.0828514325407834 0.948647089317025 -0.291832207363993 0.59570478921045 miRNATAP -1.29942347801903 1.6001633391979e-31 NA NA NA hsa-miR-142-5p KIAA2022 0.176815469040626 0.829644258081575 -0.291832207363993 0.59570478921045 MirTarget;PITA;mirMAP;miRNATAP -0.267596645415279 0.0355379729562264 NA NA NA hsa-miR-148a-3p KIAA2022 0.100907912181979 0.962574545713573 -0.291832207363993 0.59570478921045 miRNATAP -1.15097394511826 1.17845070636341e-17 NA NA NA hsa-miR-148a-5p KIAA2022 0.00159291641546666 0.998498575543413 -0.291832207363993 0.59570478921045 mirMAP;miRNATAP -1.12266657457211 4.53767358705396e-18 NA NA NA hsa-miR-15a-5p KIAA2022 0.114954548711096 0.902368422572956 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -1.48769935638591 5.97283913659391e-22 NA NA NA hsa-miR-15b-3p KIAA2022 -0.186733581829334 0.780052884104113 -0.291832207363993 0.59570478921045 mirMAP;miRNATAP -1.3490922085303 2.75853561866274e-25 NA NA NA hsa-miR-15b-5p KIAA2022 -0.00689607878522391 0.994628523271082 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -1.31417740390777 3.94722862915527e-19 NA NA NA hsa-miR-16-1-3p KIAA2022 0.336673688387428 0.263879781119291 -0.291832207363993 0.59570478921045 mirMAP -1.01192853829822 1.17729656319851e-18 NA NA NA hsa-miR-16-2-3p KIAA2022 0.0225302211167597 0.952820738839092 -0.291832207363993 0.59570478921045 MirTarget;mirMAP -1.16016162905643 3.58348566893899e-23 NA NA NA hsa-miR-16-5p KIAA2022 0.174671689106251 0.884561260745118 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -1.38252126867086 1.36483450712381e-21 NA NA NA hsa-miR-181b-5p KIAA2022 0.0792125712512002 0.94249452124277 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -0.498475066807171 0.00264729606875302 NA NA NA hsa-miR-182-5p KIAA2022 -0.152479992183316 0.936904765738824 -0.291832207363993 0.59570478921045 miRNATAP -0.711438682490716 3.40156689180094e-09 NA NA NA hsa-miR-183-5p KIAA2022 -0.160812723916992 0.928456402204374 -0.291832207363993 0.59570478921045 miRNATAP -0.736986954025454 1.13797158849687e-10 NA NA NA hsa-miR-186-5p KIAA2022 -0.103524789975763 0.922074318057442 -0.291832207363993 0.59570478921045 mirMAP -1.64787778306616 1.51817346155006e-19 NA NA NA hsa-miR-188-3p KIAA2022 0.208212289004138 0.514796885191294 -0.291832207363993 0.59570478921045 MirTarget;PITA;miRNATAP -0.420693376610308 1.07932646239265e-05 NA NA NA hsa-miR-193a-3p KIAA2022 -0.0757639382885689 0.833054724049432 -0.291832207363993 0.59570478921045 PITA -0.537283926651361 4.00767574048966e-05 NA NA NA hsa-miR-193a-5p KIAA2022 -0.120309754600177 0.904966541294366 -0.291832207363993 0.59570478921045 MirTarget -0.370881119277836 0.0287180143737239 NA NA NA hsa-miR-196a-5p KIAA2022 -0.22015594692337 0.834795780834858 -0.291832207363993 0.59570478921045 miRNATAP -0.498192332202974 7.1037753761271e-10 NA NA NA hsa-miR-196b-5p KIAA2022 -0.41125693233305 0.786431671019602 -0.291832207363993 0.59570478921045 miRNATAP -0.278920694486529 0.000582341122133102 NA NA NA hsa-miR-19a-3p KIAA2022 0.00832123546817964 0.989990781976872 -0.291832207363993 0.59570478921045 mirMAP -0.913383147263565 6.66036873785102e-17 NA NA NA hsa-miR-19b-3p KIAA2022 -0.0507144410170453 0.959611428611728 -0.291832207363993 0.59570478921045 mirMAP -1.07720322994626 2.11295290703951e-16 NA NA NA hsa-miR-200a-3p KIAA2022 -0.147527970103015 0.902426235894766 -0.291832207363993 0.59570478921045 MirTarget -0.934061873477475 5.4604048219618e-18 NA NA NA hsa-miR-23a-3p KIAA2022 -0.0188223454559413 0.990631768418334 -0.291832207363993 0.59570478921045 mirMAP -1.33647609587817 1.68458381128595e-07 NA NA NA hsa-miR-26a-1-3p KIAA2022 0.28327701999507 0.267946584880393 -0.291832207363993 0.59570478921045 mirMAP -0.877627220765139 1.43641342402647e-14 NA NA NA hsa-miR-26a-2-3p KIAA2022 -0.166204325932616 0.550909398864152 -0.291832207363993 0.59570478921045 mirMAP -0.917627660171747 2.2672309218241e-14 NA NA NA hsa-miR-26b-3p KIAA2022 -0.0550612730713693 0.918606698069173 -0.291832207363993 0.59570478921045 mirMAP;miRNATAP -1.17197238490721 4.98798526644103e-18 NA NA NA hsa-miR-26b-5p KIAA2022 0.0015045790441004 0.999045618388286 -0.291832207363993 0.59570478921045 mirMAP;miRNATAP -1.30673648324514 2.81351720772821e-13 NA NA NA hsa-miR-27a-3p KIAA2022 0.0343767097750227 0.981394253826582 -0.291832207363993 0.59570478921045 miRNATAP -1.40261351306079 1.01996077524109e-10 NA NA NA hsa-miR-27b-3p KIAA2022 -0.05565703072687 0.969586134006322 -0.291832207363993 0.59570478921045 miRNATAP -0.542588484104302 0.0369563499896419 NA NA NA hsa-miR-29a-3p KIAA2022 0.0440449516188579 0.980814196779775 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -1.07578397569831 1.92734651883004e-09 NA NA NA hsa-miR-29a-5p KIAA2022 0.0821355737825491 0.829907053101583 -0.291832207363993 0.59570478921045 mirMAP -0.949909331196495 4.3771595071772e-15 NA NA NA hsa-miR-29b-3p KIAA2022 0.00316507717068149 0.997967593788421 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -1.00957026164832 2.47457268841824e-14 NA NA NA hsa-miR-30d-3p KIAA2022 -0.0335580902863248 0.922063545694521 -0.291832207363993 0.59570478921045 mirMAP -1.03681531935299 4.75174894155898e-12 NA NA NA hsa-miR-30e-3p KIAA2022 -0.0945081226096836 0.957075120225909 -0.291832207363993 0.59570478921045 mirMAP -1.29269347353727 3.43764063750933e-07 NA NA NA hsa-miR-320a KIAA2022 -0.107569150746519 0.931865460967284 -0.291832207363993 0.59570478921045 PITA;miRNATAP -0.56943292165032 0.00065423464328352 NA NA NA hsa-miR-320b KIAA2022 -0.0277181860624873 0.972824658201018 -0.291832207363993 0.59570478921045 PITA;miRNATAP -0.40907881639957 0.00665683336868286 NA NA NA hsa-miR-320c KIAA2022 -0.634817265516566 0.0229406911033521 -0.291832207363993 0.59570478921045 PITA;miRNATAP -0.229414581945472 0.0402677587354909 NA NA NA hsa-miR-330-3p KIAA2022 -0.0147414471416165 0.959553964589524 -0.291832207363993 0.59570478921045 mirMAP -0.395770404651793 0.010327885422728 NA NA NA hsa-miR-335-3p KIAA2022 -0.169930485068435 0.871151368030036 -0.291832207363993 0.59570478921045 MirTarget -0.915947188110795 5.03767525172356e-14 NA NA NA hsa-miR-33a-3p KIAA2022 -0.478382609529613 0.0473796525588213 -0.291832207363993 0.59570478921045 MirTarget;mirMAP;miRNATAP -0.825189939320094 3.29696209200236e-13 NA NA NA hsa-miR-340-5p KIAA2022 -0.00389419024830762 0.994564832808438 -0.291832207363993 0.59570478921045 MirTarget -0.680379936470673 3.04131327821287e-05 NA NA NA hsa-miR-361-5p KIAA2022 -0.163234390350549 0.888753540633494 -0.291832207363993 0.59570478921045 PITA;mirMAP -0.89609323482324 0.000154071636723042 NA NA NA hsa-miR-369-3p KIAA2022 0.38845862357949 0.273695464084969 -0.291832207363993 0.59570478921045 mirMAP -0.563776656437264 7.998613511658e-05 NA NA NA hsa-miR-374a-3p KIAA2022 -0.250850212879389 0.858025756744383 -0.291832207363993 0.59570478921045 mirMAP -0.57797940975015 3.33964548424842e-05 NA NA NA hsa-miR-374a-5p KIAA2022 -0.22568107720489 0.754040348516339 -0.291832207363993 0.59570478921045 MirTarget;mirMAP -0.715885529451603 0.000352722361897704 NA NA NA hsa-miR-374b-5p KIAA2022 -0.266960088707788 0.755383602539075 -0.291832207363993 0.59570478921045 MirTarget;mirMAP;miRNATAP -0.809298191562136 2.80011569780206e-05 NA NA NA hsa-miR-377-3p KIAA2022 0.120020776004844 0.640825646327106 -0.291832207363993 0.59570478921045 mirMAP -0.451213792986705 0.000260154429355333 NA NA NA hsa-miR-423-5p KIAA2022 0.0339064126118833 0.9655793963387 -0.291832207363993 0.59570478921045 MirTarget -0.6353740762909 0.000171762766642034 NA NA NA hsa-miR-424-5p KIAA2022 0.146526105979442 0.876616075168222 -0.291832207363993 0.59570478921045 MirTarget;miRNATAP -0.550261316915649 1.99258058664104e-06 NA NA NA hsa-miR-425-5p KIAA2022 0.0936889263324847 0.932870183198261 -0.291832207363993 0.59570478921045 miRNATAP -1.00264106254625 8.83361680992817e-17 NA NA NA hsa-miR-429 KIAA2022 -0.238887571847831 0.835358736540541 -0.291832207363993 0.59570478921045 miRNATAP -0.955714725165043 6.64996319658601e-21 NA NA NA hsa-miR-450b-5p KIAA2022 0.148646457362083 0.720518619482493 -0.291832207363993 0.59570478921045 mirMAP -0.589903276921847 4.91854916145174e-05 NA NA NA hsa-miR-455-5p KIAA2022 0.00574212460374879 0.991180561214877 -0.291832207363993 0.59570478921045 PITA;miRanda -0.289433127760069 0.0435100246483869 NA NA NA hsa-miR-486-5p KIAA2022 -0.16110372776006 0.851150395551866 -0.291832207363993 0.59570478921045 mirMAP -0.324145155098432 0.000581430964472251 NA NA NA hsa-miR-501-5p KIAA2022 -0.103468262663096 0.736253638346517 -0.291832207363993 0.59570478921045 MirTarget;PITA;miRNATAP -0.442024675289478 1.91528073602053e-05 NA NA NA hsa-miR-505-3p KIAA2022 -0.176520656034591 0.807542265301582 -0.291832207363993 0.59570478921045 miRNATAP -1.0945516297314 1.61034899607569e-11 NA NA NA hsa-miR-532-3p KIAA2022 -0.00929099998528304 0.99000386705064 -0.291832207363993 0.59570478921045 PITA;miRNATAP -0.858203248553071 1.27113550073724e-12 NA NA NA hsa-miR-539-5p KIAA2022 0.0779551604004214 0.810026318068051 -0.291832207363993 0.59570478921045 MirTarget;mirMAP;miRNATAP -0.572695721886956 0.000192031248932792 NA NA NA hsa-miR-548o-3p KIAA2022 0.0471744420039305 0.839937385468575 -0.291832207363993 0.59570478921045 MirTarget -0.632269474867641 5.35403424598342e-07 NA NA NA hsa-miR-576-5p KIAA2022 -0.0551664166879235 0.884235321656318 -0.291832207363993 0.59570478921045 mirMAP -1.27703646734351 1.21048437352487e-23 NA NA NA hsa-miR-584-5p KIAA2022 -0.161825173854309 0.888884520738016 -0.291832207363993 0.59570478921045 mirMAP -0.534238589241506 4.44826466097308e-09 NA NA NA hsa-miR-589-3p KIAA2022 -0.0626170938535065 0.807656131646557 -0.291832207363993 0.59570478921045 mirMAP -0.703341998326202 2.10045589550155e-11 NA NA NA hsa-miR-590-3p KIAA2022 0.0829620326684548 0.810708708264937 -0.291832207363993 0.59570478921045 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.931343625017322 1.66566871816878e-17 NA NA NA hsa-miR-625-3p KIAA2022 -0.152485582149403 0.899037687047363 -0.291832207363993 0.59570478921045 mirMAP -0.702594746877668 1.5195208817626e-12 NA NA NA hsa-miR-940 KIAA2022 -0.0800854013678642 0.833581451468191 -0.291832207363993 0.59570478921045 miRNATAP -0.519448591752001 1.32879713806725e-07 NA NA NA hsa-miR-942-5p KIAA2022 -0.0335057484411028 0.942305199873267 -0.291832207363993 0.59570478921045 MirTarget -1.03606570926762 1.27699042198806e-22 NA NA NA hsa-miR-96-5p KIAA2022 0.0812346609576227 0.885285229701925 -0.291832207363993 0.59570478921045 MirTarget;TargetScan;miRNATAP -0.946482496374288 4.20986512082109e-17 NA NA NA hsa-miR-222-3p KIF16B 0.067264556454159 0.934147523407911 -0.300657897827466 0.702831798822909 miRNATAP -0.143849468503368 0.0134349184393744 NA NA NA hsa-miR-10a-5p KIF1A -0.103091346403293 0.963361104257071 -0.450319331834301 0.401830141178473 mirMAP -0.54324948203095 0.00106652450044283 NA NA NA hsa-miR-125b-5p KIF24 0.00744496603712985 0.994576506820994 -0.0233411234569343 0.959588423926214 miRNAWalker2_validate -0.124418238470575 0.000156771862412697 NA NA NA hsa-miR-222-3p KIF5C 0.067264556454159 0.934147523407911 -0.112196992793018 0.673614411215191 miRNAWalker2_validate -0.549680573851377 7.11867454189155e-09 NA NA NA hsa-miR-320c KIRREL -0.634817265516566 0.0229406911033521 -0.161424422306477 0.765496887513851 mirMAP -0.168669281728872 0.0428453546269079 NA NA NA hsa-miR-222-3p KIT 0.067264556454159 0.934147523407911 0.249029056400396 0.59366888253831 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.686230651819729 7.25180673792435e-09 NA NA NA hsa-miR-10a-5p KL -0.103091346403293 0.963361104257071 -0.23609257600377 0.471227576061682 miRNATAP -0.2399187600813 0.0221453244023198 NA NA NA hsa-miR-10a-5p KLF7 -0.103091346403293 0.963361104257071 -0.0809859700076296 0.839480743786746 miRNATAP -0.198819505553632 0.0112962377140681 NA NA NA hsa-miR-320c KLF8 -0.634817265516566 0.0229406911033521 -0.0749510057863764 0.77993681001492 mirMAP -0.135039277771042 0.0400060996429448 NA NA NA hsa-miR-10a-5p KLHL29 -0.103091346403293 0.963361104257071 -0.0890419582861464 0.871382385633796 MirTarget;miRNATAP -0.237142313945394 0.000764689499058138 NA NA NA hsa-miR-10a-5p KLHL6 -0.103091346403293 0.963361104257071 -0.0450737885585792 0.916062801513748 miRNAWalker2_validate -0.469264121803774 5.61174482823937e-06 NA NA NA hsa-miR-1275 KLK10 -0.092958576443477 0.78712696322568 0.191724419704649 0.815969571656775 MirTarget -0.423250974121424 0.000422879514472909 NA NA NA hsa-miR-100-5p KPNA2 -0.0835426508859793 0.958163253942357 0.0223535488469171 0.982411015455028 miRNAWalker2_validate -0.170991941106239 2.92862390188809e-07 NA NA NA hsa-miR-125b-5p KPNB1 0.00744496603712985 0.994576506820994 -0.0796262876690452 0.944389156932139 miRNAWalker2_validate -0.112933003489494 7.33476114456875e-08 NA NA NA hsa-miR-1275 KRT1 -0.092958576443477 0.78712696322568 0.587690309474841 0.402919895541066 MirTarget -0.288708686666206 0.00214086450640197 NA NA NA hsa-miR-320c KRT14 -0.634817265516566 0.0229406911033521 0.346337073752456 0.641418680760695 miRanda -0.337046790310695 0.00642497044002454 NA NA NA hsa-miR-1275 KRT81 -0.092958576443477 0.78712696322568 0.105494701785342 0.80485787010019 MirTarget -0.26012172446182 0.000725557755643607 NA NA NA hsa-miR-10a-5p LAMC1 -0.103091346403293 0.963361104257071 -0.151496953857737 0.8859394746859 miRNAWalker2_validate -0.149516679643707 0.000235066112725927 NA NA NA hsa-miR-143-3p LARP4 -0.0402404826858778 0.987317207979986 -0.0356217892744723 0.966361731079951 MirTarget;miRNATAP -0.15675179723503 3.01450115327233e-07 NA NA NA hsa-miR-320c LBH -0.634817265516566 0.0229406911033521 -0.025102741360266 0.975928383099818 MirTarget;miRanda -0.106448805163754 0.0414067253577297 NA NA NA hsa-miR-10a-5p LCA5 -0.103091346403293 0.963361104257071 -0.262165923554925 0.349613651560075 miRNAWalker2_validate;MirTarget -0.185939058278959 0.00189778912698138 NA NA NA hsa-miR-222-3p LEPROT 0.067264556454159 0.934147523407911 -0.201488187804514 0.75113361234546 MirTarget -0.287841760836219 6.02140931355784e-09 NA NA NA hsa-miR-1275 LHX6 -0.092958576443477 0.78712696322568 -0.222530099340029 0.473842155194774 MirTarget -0.163126667296928 0.00314171100721459 NA NA NA hsa-miR-222-3p LIFR 0.067264556454159 0.934147523407911 -0.234093055486915 0.528297313060179 miRNATAP -0.887267241701075 1.34559387971847e-14 NA NA NA hsa-miR-143-3p LIMD1 -0.0402404826858778 0.987317207979986 -0.0926419319643506 0.906889290994868 mirMAP -0.147373707341453 4.21976909354506e-07 NA NA NA hsa-miR-10a-5p LIMD2 -0.103091346403293 0.963361104257071 0.136680652980266 0.792110628184571 mirMAP -0.342834424707623 2.35801538929394e-08 NA NA NA hsa-miR-1275 LIMD2 -0.092958576443477 0.78712696322568 0.136680652980266 0.792110628184571 mirMAP -0.122419273935332 0.00309766554403555 NA NA NA hsa-miR-222-3p LIMS1 0.067264556454159 0.934147523407911 -0.236754171546962 0.690032075233387 MirTarget -0.226832035003514 4.1109673750505e-07 NA NA NA hsa-miR-10a-5p LIX1L -0.103091346403293 0.963361104257071 0.0430995299109562 0.932644334674615 MirTarget -0.245978844023649 1.62384351031266e-05 NA NA NA hsa-miR-1275 LIX1L -0.092958576443477 0.78712696322568 0.0430995299109562 0.932644334674615 MirTarget -0.155186369296251 3.6054806369011e-05 NA NA NA hsa-miR-125b-5p LMNB2 0.00744496603712985 0.994576506820994 -0.126637776463517 0.90652768592047 mirMAP -0.109821500832195 0.000289420183565491 NA NA NA hsa-miR-320c LMO3 -0.634817265516566 0.0229406911033521 -0.295617572665164 0.575514068779141 MirTarget;PITA;miRanda;miRNATAP -0.290565587918879 0.0433944032608583 NA NA NA hsa-miR-320c LOXL3 -0.634817265516566 0.0229406911033521 0.107526850556012 0.76465694576525 miRanda -0.137391268058484 0.00367880616791155 NA NA NA hsa-miR-1275 LOXL4 -0.092958576443477 0.78712696322568 0.100775942524385 0.747183507237734 MirTarget -0.2362904455589 0.00023708764008902 NA NA NA hsa-miR-143-3p LPAR2 -0.0402404826858778 0.987317207979986 0.0754744982259474 0.905108850595796 miRNATAP -0.190315269910427 6.36771230241007e-07 NA NA NA hsa-miR-10a-5p LRFN1 -0.103091346403293 0.963361104257071 0.0345241862157722 0.906805642380177 miRNAWalker2_validate -0.523460984047234 1.31085852608337e-08 NA NA NA hsa-miR-125b-5p LRP10 0.00744496603712985 0.994576506820994 -0.062151577022064 0.957185051235274 mirMAP -0.107990583370141 0.00542322717780408 NA NA NA hsa-miR-10a-5p LRP12 -0.103091346403293 0.963361104257071 0.0386197347935657 0.939128705568163 MirTarget -0.220819652602553 0.00074001295425856 NA NA NA hsa-miR-10a-5p LRP3 -0.103091346403293 0.963361104257071 0.113623682600594 0.880388780594871 miRNAWalker2_validate -0.144161036779511 0.018943117377739 NA NA NA hsa-miR-320c LRRC17 -0.634817265516566 0.0229406911033521 0.10575304492049 0.700865939683494 miRanda -0.144396854693052 0.0401885619332523 NA NA NA hsa-miR-320c LRRC4 -0.634817265516566 0.0229406911033521 0.148304147634518 0.630922727952888 miRanda;miRNATAP -0.209411182521983 0.00934190023651574 NA NA NA hsa-miR-125b-5p LRRC8B 0.00744496603712985 0.994576506820994 -0.204102977459344 0.761500766722138 MirTarget;miRNATAP -0.11238636928782 1.17685474222302e-05 NA NA NA hsa-miR-143-3p LRRC8B -0.0402404826858778 0.987317207979986 -0.204102977459344 0.761500766722138 MirTarget -0.105984450758558 0.0041029889309822 NA NA NA hsa-miR-10a-5p LRRC8C -0.103091346403293 0.963361104257071 -0.0334141664693837 0.940697230475302 MirTarget -0.283679417030277 4.40079287653321e-07 NA NA NA hsa-miR-1275 LRRC8C -0.092958576443477 0.78712696322568 -0.0334141664693837 0.940697230475302 MirTarget -0.238562827315106 4.29601190156887e-11 NA NA NA hsa-miR-1275 LRRN2 -0.092958576443477 0.78712696322568 0.218176515107093 0.592184693939749 MirTarget -0.1865827052415 0.0221668526024936 NA NA NA hsa-miR-10a-5p LTBP1 -0.103091346403293 0.963361104257071 -0.0508343258457948 0.954313699210381 MirTarget -0.433962209141362 2.5342581299569e-08 NA NA NA hsa-miR-1275 LTBP2 -0.092958576443477 0.78712696322568 -0.191660662649141 0.817959714866624 MirTarget -0.170420056799602 0.00597601210040321 NA NA NA hsa-miR-222-3p LUZP2 0.067264556454159 0.934147523407911 0.260194523055869 0.592274398919139 MirTarget -0.818334797177764 1.13719492268607e-07 NA NA NA hsa-miR-10a-5p LYNX1 -0.103091346403293 0.963361104257071 -0.0634572119236786 0.859134693880415 mirMAP -0.5136654832918 3.36108010353371e-07 NA NA NA hsa-miR-1275 LYNX1 -0.092958576443477 0.78712696322568 -0.0634572119236786 0.859134693880415 MirTarget;miRNATAP -0.169778403604603 0.0120989717194426 NA NA NA hsa-miR-222-3p LYNX1 0.067264556454159 0.934147523407911 -0.0634572119236786 0.859134693880415 MirTarget -0.638888635401195 3.09004977729615e-08 NA NA NA hsa-miR-1275 LZTS1 -0.092958576443477 0.78712696322568 0.343812736833577 0.422896017896671 mirMAP -0.14986522749052 0.00184820530123703 NA NA NA hsa-miR-222-3p MACF1 0.067264556454159 0.934147523407911 -0.126076363798357 0.903055324756794 miRNAWalker2_validate -0.147677609489953 0.00106691442509503 NA NA NA hsa-miR-320c MAGEL2 -0.634817265516566 0.0229406911033521 0.0801856851296741 0.85017186723155 PITA;miRanda -0.275305422381257 0.00244985415881737 NA NA NA hsa-miR-320c MAOB -0.634817265516566 0.0229406911033521 0.438363810656074 0.403184260011673 miRanda -0.228280638351486 0.0490539038342133 NA NA NA hsa-miR-1275 MAP1A -0.092958576443477 0.78712696322568 0.0555594334736571 0.924151019121734 MirTarget;PITA -0.169347685427443 0.00170432573753468 NA NA NA hsa-miR-222-3p MAP1B 0.067264556454159 0.934147523407911 0.0246099491928571 0.96571338120043 miRNAWalker2_validate -0.655766104551976 2.8569772076826e-13 NA NA NA hsa-miR-320c MAP1B -0.634817265516566 0.0229406911033521 0.0246099491928571 0.96571338120043 MirTarget;PITA;miRanda;miRNATAP -0.167578843769811 0.0135292451128697 NA NA NA hsa-miR-125b-5p MAP3K13 0.00744496603712985 0.994576506820994 -0.192476104478422 0.521797111381796 miRNATAP -0.112192432729334 0.00303039836480913 NA NA NA hsa-miR-222-3p MAP3K2 0.067264556454159 0.934147523407911 -0.14198727524251 0.825373501671984 MirTarget -0.111707697435185 0.0015479490184321 NA NA NA hsa-miR-1275 MAP4K1 -0.092958576443477 0.78712696322568 -0.082846284834958 0.833553411912169 MirTarget -0.201324729828088 0.00772430248218323 NA NA NA hsa-miR-320c MAP6 -0.634817265516566 0.0229406911033521 0.121684703826241 0.683235043357614 miRanda -0.157949428013332 0.0488402462542167 NA NA NA hsa-miR-222-3p MAPK10 0.067264556454159 0.934147523407911 -0.252368019473092 0.411625913483372 miRNATAP -0.880593901403205 6.71481319542536e-17 NA NA NA hsa-miR-100-5p MAPK1IP1L -0.0835426508859793 0.958163253942357 0.0244257386794358 0.978131957255827 miRNAWalker2_validate -0.123572101361586 1.2513291403147e-07 NA NA NA hsa-miR-100-5p MAPK6 -0.0835426508859793 0.958163253942357 -0.0111271200116523 0.989389149636344 miRNAWalker2_validate -0.115438356408989 0.000584030518776541 NA NA NA hsa-miR-10a-5p MAPKBP1 -0.103091346403293 0.963361104257071 -0.0212361662049476 0.970742623332877 MirTarget;miRNATAP -0.160536594147683 1.26657763382701e-06 NA NA NA hsa-miR-10a-5p MAPT -0.103091346403293 0.963361104257071 0.284737102197161 0.459514585880155 mirMAP -0.528398526604644 2.02468404671292e-05 NA NA NA hsa-miR-1275 MAPT -0.092958576443477 0.78712696322568 0.284737102197161 0.459514585880155 MirTarget -0.337832821862335 3.44977119978374e-05 NA NA NA hsa-miR-125b-5p MAT2A 0.00744496603712985 0.994576506820994 -0.0388503123918511 0.970996367720915 miRNATAP -0.116955065079523 1.62482995878854e-06 NA NA NA hsa-miR-1275 MCC -0.092958576443477 0.78712696322568 -0.108619381509925 0.79876166841456 MirTarget -0.186474091913244 0.000138863586807219 NA NA NA hsa-miR-320c MCC -0.634817265516566 0.0229406911033521 -0.108619381509925 0.79876166841456 mirMAP -0.141986016771331 0.0223154326384969 NA NA NA hsa-miR-10a-5p MDGA1 -0.103091346403293 0.963361104257071 -0.147286740836177 0.651760366996345 mirMAP -0.567819942787164 4.4472841256212e-10 NA NA NA hsa-miR-143-3p MDM2 -0.0402404826858778 0.987317207979986 -0.00779309107585835 0.992382222974178 miRNAWalker2_validate -0.16317524344501 0.00124362026384159 NA NA NA hsa-miR-222-3p MEGF9 0.067264556454159 0.934147523407911 0.0309190715124821 0.960075554702231 MirTarget;miRNATAP -0.168223860393398 0.000165220007724546 NA NA NA hsa-miR-320c MEOX1 -0.634817265516566 0.0229406911033521 -0.327530257246204 0.354373855037491 mirMAP -0.227465185116874 0.0157004136905123 NA NA NA hsa-miR-106a-5p METTL7A -0.220241577853689 0.671337298786352 -0.0495918936264896 0.94766072192446 mirMAP -0.197267176524875 0.00859723919220674 NA NA NA hsa-miR-106b-5p METTL7A 0.0054863796897946 0.996055976715358 -0.0495918936264896 0.94766072192446 mirMAP -0.213276081254305 0.0142567329917669 NA NA NA hsa-miR-16-2-3p METTL7A 0.0225302211167597 0.952820738839092 -0.0495918936264896 0.94766072192446 mirMAP -0.155463703259412 0.0255730861080653 NA NA NA hsa-miR-17-5p METTL7A 0.0171021356945324 0.989602604642911 -0.0495918936264896 0.94766072192446 mirMAP -0.247556174790865 0.000164277270470336 NA NA NA hsa-miR-20a-5p METTL7A 0.0315169008595895 0.979392076246529 -0.0495918936264896 0.94766072192446 mirMAP -0.239830859219213 0.000212574325957642 NA NA NA hsa-miR-335-3p METTL7A -0.169930485068435 0.871151368030036 -0.0495918936264896 0.94766072192446 mirMAP -0.158568159419687 0.0219112872674711 NA NA NA hsa-miR-548o-3p METTL7A 0.0471744420039305 0.839937385468575 -0.0495918936264896 0.94766072192446 mirMAP -0.150207216426357 0.030243735280473 NA NA NA hsa-miR-93-5p METTL7A -0.093851027778495 0.955646810234554 -0.0495918936264896 0.94766072192446 mirMAP -0.17308363333196 0.0356583656198101 NA NA NA hsa-miR-222-3p MEX3A 0.067264556454159 0.934147523407911 0.0656376933883034 0.918315156069444 MirTarget -0.319425410096325 0.00252105274758231 NA NA NA hsa-miR-1275 MEX3B -0.092958576443477 0.78712696322568 0.00653132917589261 0.980311247404162 mirMAP -0.180464652323713 4.16338062049386e-05 NA NA NA hsa-miR-320c MEX3B -0.634817265516566 0.0229406911033521 0.00653132917589261 0.980311247404162 miRanda;miRNATAP -0.115511573130236 0.0395528818710177 NA NA NA hsa-miR-222-3p MIA3 0.067264556454159 0.934147523407911 -0.0925839679118567 0.916917300556278 MirTarget;miRNATAP -0.156058907164807 0.00141325001579082 NA NA NA hsa-miR-125b-5p MLEC 0.00744496603712985 0.994576506820994 -0.0640190283771265 0.96085567242483 mirMAP -0.105303518075127 0.00204790426085739 NA NA NA hsa-miR-125b-5p MLX 0.00744496603712985 0.994576506820994 0.1028822535992 0.909526245607082 MirTarget -0.122193318265063 3.03443055172527e-07 NA NA NA hsa-miR-320c MMP12 -0.634817265516566 0.0229406911033521 -0.228818502341312 0.76790638711185 miRanda -0.23117662438461 0.0333598583975662 NA NA NA hsa-miR-1275 MMP14 -0.092958576443477 0.78712696322568 0.0160163191083313 0.989340597395443 MirTarget -0.174407096651073 2.44647245296016e-05 NA NA NA hsa-miR-125b-5p MMP15 0.00744496603712985 0.994576506820994 -0.0306378285221616 0.975734235621116 MirTarget -0.100193230123565 0.00548283576484972 NA NA NA hsa-miR-451a MMP2 -0.150707356551769 0.885791087039658 -0.04808783783621 0.966599594067026 miRNAWalker2_validate;miRTarBase -0.234849684027951 0.000972688446119525 27173190 Furthermore miR-451 overexpression reduced MMP-2 protein expression levels; In addition neutralization of miR-451 by anti-miR-451 antibody reversed the effect of propofol on cell proliferation and apoptosis and upregulated MMP-2 expression in the SGC-7901 cells; Propofol effectively inhibited proliferation and induced apoptosis in gastric cancer cells which was partly owing to the downregulation of MMP-2 expression by miR-451 gastric cancer hsa-miR-451a MMP9 -0.150707356551769 0.885791087039658 -0.230832946134225 0.780859518239833 miRNAWalker2_validate;miRTarBase -0.221916455608912 0.00845791488798268 NA NA NA hsa-miR-1275 MMRN2 -0.092958576443477 0.78712696322568 -0.0104978413870516 0.985527965206433 MirTarget -0.212139979692182 5.19854202710456e-07 NA NA NA hsa-miR-320c MNDA -0.634817265516566 0.0229406911033521 0.0136821086811922 0.972535654397192 miRanda -0.184416531596582 0.037530145496431 NA NA NA hsa-miR-143-3p MOGS -0.0402404826858778 0.987317207979986 -0.0236991727480325 0.979744135490229 MirTarget -0.121329376397312 4.27186923062054e-07 NA NA NA hsa-miR-1275 MRC1 -0.092958576443477 0.78712696322568 0.205033362783412 0.706592875183989 MirTarget -0.363647201572172 7.24713860308833e-06 NA NA NA hsa-miR-10a-5p MRC2 -0.103091346403293 0.963361104257071 0.187935413751942 0.829817042585572 miRNAWalker2_validate;mirMAP -0.448254236244523 4.82726122456562e-08 NA NA NA hsa-miR-100-5p MRPS33 -0.0835426508859793 0.958163253942357 0.0357525661574103 0.964350148490672 miRNAWalker2_validate -0.123040231604275 0.00057386496453716 NA NA NA hsa-miR-125b-5p MRTO4 0.00744496603712985 0.994576506820994 -0.0410862217880767 0.961187789300439 miRNAWalker2_validate -0.103881353561387 0.00118066532105433 NA NA NA hsa-miR-1275 MRVI1 -0.092958576443477 0.78712696322568 -0.135061370920043 0.839755027080007 MirTarget -0.222283686243454 9.58296546112784e-05 NA NA NA hsa-miR-320c MRVI1 -0.634817265516566 0.0229406911033521 -0.135061370920043 0.839755027080007 miRanda;mirMAP -0.192794394164983 0.00762091547871096 NA NA NA hsa-miR-320c MSRB3 -0.634817265516566 0.0229406911033521 0.0197401195842479 0.975517653463319 miRanda -0.203070155839441 0.013249019849303 NA NA NA hsa-miR-125b-5p MTMR4 0.00744496603712985 0.994576506820994 -0.163709913719265 0.835929664008947 miRNAWalker2_validate -0.103585210438255 1.09691337345553e-05 NA NA NA hsa-miR-222-3p MTMR6 0.067264556454159 0.934147523407911 0.115003373544444 0.887050024881419 MirTarget -0.129617404399355 0.00348503570122726 NA NA NA hsa-miR-125b-5p MTUS1 0.00744496603712985 0.994576506820994 -0.0580362394530409 0.94561450593141 miRNATAP -0.100572153344024 0.0223505301793786 NA NA NA hsa-miR-125b-5p MUC1 0.00744496603712985 0.994576506820994 0.302689013715088 0.762385223005328 miRNAWalker2_validate -0.247424635755378 0.0175572799874553 NA NA NA hsa-miR-1275 MYCT1 -0.092958576443477 0.78712696322568 0.00986020057956538 0.975562737849565 MirTarget -0.210635132599753 6.09752127535572e-08 NA NA NA hsa-miR-1275 MYL9 -0.092958576443477 0.78712696322568 0.0823876357902416 0.938248832917461 mirMAP -0.211530121311366 0.000488804535744628 NA NA NA hsa-miR-222-3p MYLIP 0.067264556454159 0.934147523407911 -0.0946391620581082 0.894353673145026 MirTarget -0.188524341763474 1.53712027217547e-05 NA NA NA hsa-miR-320c MYLK -0.634817265516566 0.0229406911033521 -0.0200509786982694 0.983078558573798 miRanda -0.185914424577691 0.0219464659744539 NA NA NA hsa-miR-125b-5p MYO19 0.00744496603712985 0.994576506820994 0.00444411392600674 0.995752367417234 miRNAWalker2_validate -0.164049399261742 5.08356586436922e-08 NA NA NA hsa-miR-143-3p MYO6 -0.0402404826858778 0.987317207979986 -0.0522319941656084 0.956796852849081 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.12820221666255 0.000739058042355164 20353999 A computational search indicated the 3'-untranslated region UTR of the mRNA for myosin VI MYO6 as a potential target for both miR-143 and miR-145 the expression of which was reduced in the tumor tissues; In luciferase reporter analysis we find a significant negative regulatory effect on the MYO6 3'UTR by both miR-143 and miR-145; Mutation of the potential binding sites for miR-143 and miR-145 in the MYO6 3'UTR resulted in a loss of responsiveness to the corresponding miRNA; Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer prostate cancer hsa-miR-1468-5p MYOT -0.0572635876921077 0.861797087475115 0.161052964917562 0.820904838640844 MirTarget -0.453904390519391 0.000395218631238686 NA NA NA hsa-miR-335-5p MYOT -0.0823503258190108 0.879911427250447 0.161052964917562 0.820904838640844 miRNAWalker2_validate -0.765328171260749 9.75938469529265e-10 NA NA NA hsa-miR-376c-3p MYOT 0.381679095584152 0.284622432271711 0.161052964917562 0.820904838640844 MirTarget -0.357370274275784 0.00492519703903785 NA NA NA hsa-miR-455-5p MYOT 0.00574212460374879 0.991180561214877 0.161052964917562 0.820904838640844 miRanda -0.677221041244662 1.50936082366909e-06 NA NA NA hsa-miR-486-5p MYOT -0.16110372776006 0.851150395551866 0.161052964917562 0.820904838640844 miRanda -0.35523142990817 0.00016517711314412 NA NA NA hsa-miR-590-3p MYOT 0.0829620326684548 0.810708708264937 0.161052964917562 0.820904838640844 PITA;miRanda;mirMAP -0.724774253082527 1.80305823585866e-10 NA NA NA hsa-miR-935 MYOT 0.663203605956947 0.182698303887071 0.161052964917562 0.820904838640844 PITA -0.159340142405742 0.0084636838068933 NA NA NA hsa-miR-1275 N4BP3 -0.092958576443477 0.78712696322568 0.0106722513031174 0.977543614965485 MirTarget;PITA -0.163972064327193 5.41086707919772e-05 NA NA NA hsa-miR-222-3p NAP1L5 0.067264556454159 0.934147523407911 0.279918154848711 0.250773225630863 MirTarget;miRNATAP -0.153267443029985 0.0065114208552737 NA NA NA hsa-miR-222-3p NBPF3 0.067264556454159 0.934147523407911 -0.150863201764635 0.685892019742206 MirTarget -0.228121752030557 0.00434850532999393 NA NA NA hsa-miR-320c NCAM2 -0.634817265516566 0.0229406911033521 0.105401036403575 0.826743686208273 miRanda -0.294272888228867 0.0182000637410436 NA NA NA hsa-miR-222-3p NCKAP5L 0.067264556454159 0.934147523407911 -0.0837075615933887 0.888167971257656 miRNAWalker2_validate -0.188254466580593 0.000295100993506261 NA NA NA hsa-miR-125b-5p NCLN 0.00744496603712985 0.994576506820994 0.0301661528487962 0.976958082562744 mirMAP -0.10148774124983 0.000215376759239344 NA NA NA hsa-miR-10a-5p NCS1 -0.103091346403293 0.963361104257071 0.0350025901368971 0.961274405546445 mirMAP -0.270512775277885 1.59994626000115e-06 NA NA NA hsa-miR-320c NDP -0.634817265516566 0.0229406911033521 -0.129413105607036 0.78690455064815 miRanda -0.330547839298115 0.00604395565549921 NA NA NA hsa-miR-100-5p NDUFA2 -0.0835426508859793 0.958163253942357 0.193174173269236 0.805737641616334 miRNAWalker2_validate -0.148869864572295 1.07417414085564e-06 NA NA NA hsa-miR-100-5p NDUFA9 -0.0835426508859793 0.958163253942357 0.199853281087477 0.835015322782597 miRNAWalker2_validate -0.183738852723739 4.91833361400285e-08 NA NA NA hsa-miR-143-3p NECAP1 -0.0402404826858778 0.987317207979986 0.0366290793478754 0.959333371760531 MirTarget;miRNATAP -0.163851694330145 6.27095808689959e-07 NA NA NA hsa-miR-320c NEFM -0.634817265516566 0.0229406911033521 -0.350179135306587 0.532058225415324 miRanda -0.268112457749433 0.0106842379108792 NA NA NA hsa-miR-1275 NFAM1 -0.092958576443477 0.78712696322568 -0.080132306822938 0.856407688219658 MirTarget -0.162629516000879 0.000594782578147006 NA NA NA hsa-miR-10a-5p NFASC -0.103091346403293 0.963361104257071 0.11674031379005 0.820030626080351 miRNATAP -0.283467377380223 0.00336520801920513 NA NA NA hsa-miR-222-3p NFATC2 0.067264556454159 0.934147523407911 -0.28636594802341 0.493895397714357 MirTarget -0.320366258251818 0.012848061977003 NA NA NA hsa-miR-320c NFATC4 -0.634817265516566 0.0229406911033521 0.408434526176984 0.466418021287997 miRanda;mirMAP -0.136540488247642 0.00651845172795593 NA NA NA hsa-miR-143-3p NFXL1 -0.0402404826858778 0.987317207979986 -0.0678707732208679 0.905372176016886 MirTarget -0.158029156407567 9.98653124069539e-07 NA NA NA hsa-miR-10a-5p NGFR -0.103091346403293 0.963361104257071 0.152412839711161 0.726141407993381 mirMAP -0.57553024334957 1.92818293620859e-05 NA NA NA hsa-miR-1275 NGFR -0.092958576443477 0.78712696322568 0.152412839711161 0.726141407993381 mirMAP -0.287453379390587 0.00128898690353953 NA NA NA hsa-miR-125b-5p NIPA1 0.00744496603712985 0.994576506820994 -0.0366082063072559 0.95632282478289 miRNATAP -0.127906966391961 1.55113482845457e-05 NA NA NA hsa-miR-222-3p NIPAL4 0.067264556454159 0.934147523407911 -0.182364879049822 0.636466438387363 MirTarget -0.491828928030868 0.000307089168031079 NA NA NA hsa-miR-1275 NKAIN4 -0.092958576443477 0.78712696322568 0.289376982969857 0.592382919308474 MirTarget -0.250435944302542 0.0053519959094926 NA NA NA hsa-miR-1275 NLGN2 -0.092958576443477 0.78712696322568 0.105620674512317 0.849945411248173 MirTarget;PITA -0.199039960553998 2.53746023921575e-05 NA NA NA hsa-miR-320c NLRP3 -0.634817265516566 0.0229406911033521 0.118367409274577 0.68535246519983 miRanda -0.162924310246205 0.0190788363113044 NA NA NA hsa-miR-100-5p NOP2 -0.0835426508859793 0.958163253942357 0.105863477928053 0.902246774510618 miRNAWalker2_validate -0.144404909000204 7.85149178939483e-07 NA NA NA hsa-miR-222-3p NOVA1 0.067264556454159 0.934147523407911 0.14831633507406 0.746847129242776 miRNATAP -0.867248412681112 1.37884214664022e-08 NA NA NA hsa-miR-10a-5p NPAS3 -0.103091346403293 0.963361104257071 -0.0237998817376646 0.960922959573748 miRNATAP -0.432924700666929 0.000305455032894752 NA NA NA hsa-miR-125b-5p NPM1 0.00744496603712985 0.994576506820994 0.0574722772663492 0.965142901351024 miRNAWalker2_validate -0.110510728577589 0.000676048514923997 NA NA NA hsa-miR-320c NPR3 -0.634817265516566 0.0229406911033521 0.350771104088307 0.500210408724306 miRanda;mirMAP -0.283082733932795 0.0299371399911506 NA NA NA hsa-miR-10a-5p NPTX1 -0.103091346403293 0.963361104257071 -0.0497144979371593 0.921265036896805 miRNAWalker2_validate -0.636302453245573 6.02162681904727e-05 NA NA NA hsa-miR-320c NPTX2 -0.634817265516566 0.0229406911033521 0.584350336870768 0.375665752602544 PITA;miRanda -0.341624820881513 0.015022002613171 NA NA NA hsa-miR-10a-5p NPTXR -0.103091346403293 0.963361104257071 -0.10601018131079 0.819181562630299 mirMAP -0.685140180760178 2.79455704285894e-09 NA NA NA hsa-miR-10a-5p NR2F2 -0.103091346403293 0.963361104257071 -0.192528143382628 0.811165394611478 miRNATAP -0.12120185974199 0.0061004791757212 NA NA NA hsa-miR-320c NR3C1 -0.634817265516566 0.0229406911033521 -0.105581743569971 0.851688563980077 PITA;miRanda;miRNATAP -0.128871196632362 0.0461058409319174 NA NA NA hsa-miR-125b-5p NRARP 0.00744496603712985 0.994576506820994 0.07637886657698 0.930946623654168 miRNAWalker2_validate -0.21544142186912 7.70797837636122e-06 NA NA NA hsa-miR-222-3p NRG1 0.067264556454159 0.934147523407911 -0.543111499296565 0.217755862582228 miRNATAP -0.450440315199706 0.003290541002946 NA NA NA hsa-miR-320c NRIP3 -0.634817265516566 0.0229406911033521 0.152878468438377 0.540988970072054 miRanda -0.158454293308804 0.00969152460186731 NA NA NA hsa-miR-222-3p NRK 0.067264556454159 0.934147523407911 -0.314779888908194 0.516400580538148 MirTarget;miRNATAP -1.066407740366 8.63530617946854e-11 NA NA NA hsa-miR-10a-5p NRP2 -0.103091346403293 0.963361104257071 0.194668620949071 0.790772968177369 miRNATAP -0.428731213845573 1.2149021956372e-07 NA NA NA hsa-miR-222-3p NRXN1 0.067264556454159 0.934147523407911 -0.200356112665491 0.761538577930511 MirTarget -1.17688823571886 7.28076920018414e-10 NA NA NA hsa-miR-222-3p NTF3 0.067264556454159 0.934147523407911 -0.11109272197589 0.769955704004311 miRNATAP -0.52313575472335 8.7686929594132e-07 NA NA NA hsa-miR-1275 NTN1 -0.092958576443477 0.78712696322568 -0.392889705243565 0.342843484497071 mirMAP -0.158438660423228 0.0109144663092571 NA NA NA hsa-miR-1275 NTNG2 -0.092958576443477 0.78712696322568 0.225863705891915 0.36020849736003 mirMAP -0.139384331947457 0.00651803062556924 NA NA NA hsa-miR-10a-5p NTRK3 -0.103091346403293 0.963361104257071 -0.361662467476962 0.516401142480144 mirMAP -0.417569594798788 0.0013967258897816 NA NA NA hsa-miR-320c NTRK3 -0.634817265516566 0.0229406911033521 -0.361662467476962 0.516401142480144 mirMAP -0.221754039787417 0.0412470246846411 NA NA NA hsa-miR-1275 NUAK1 -0.092958576443477 0.78712696322568 -0.0251239747342002 0.963244339520168 MirTarget -0.14961127001559 0.000927524631886892 NA NA NA hsa-miR-100-5p NUDCD2 -0.0835426508859793 0.958163253942357 0.115027545905086 0.858595527697435 miRNAWalker2_validate -0.109879022167292 1.28684097008009e-05 NA NA NA hsa-miR-143-3p NUS1 -0.0402404826858778 0.987317207979986 -0.0891991918905184 0.918661309012364 MirTarget -0.105177885511692 0.000327377302231893 NA NA NA hsa-miR-1275 NXPH4 -0.092958576443477 0.78712696322568 0.222668016475948 0.658574150651341 MirTarget -0.282009898597265 0.00916368094258872 NA NA NA hsa-miR-100-5p ODC1 -0.0835426508859793 0.958163253942357 -0.140395658084488 0.89855316943475 miRNAWalker2_validate -0.159805185529057 6.52280430796089e-06 NA NA NA hsa-miR-1275 OLFML1 -0.092958576443477 0.78712696322568 -0.0713377505065425 0.858526015975065 MirTarget -0.158232273654416 0.00231565351266921 NA NA NA hsa-miR-320c OLR1 -0.634817265516566 0.0229406911033521 0.565474162343413 0.218398482686814 miRanda -0.323293739653023 0.00320061771902238 NA NA NA hsa-miR-143-3p ONECUT2 -0.0402404826858778 0.987317207979986 -0.0732668617210446 0.870293753712334 mirMAP;miRNATAP -0.30661375230104 0.0313874942761911 NA NA NA hsa-miR-10a-5p ORAI2 -0.103091346403293 0.963361104257071 -0.0431914618031701 0.952566961825817 miRNAWalker2_validate -0.179034201768963 0.000239275599966022 NA NA NA hsa-miR-320c OSM -0.634817265516566 0.0229406911033521 0.454980101595323 0.263725941166324 miRanda -0.242582653066802 0.0138340297021142 NA NA NA hsa-miR-451a OSR1 -0.150707356551769 0.885791087039658 0.303170083922104 0.521605315514864 MirTarget;miRNATAP -0.298289526351125 0.00400163039198194 NA NA NA hsa-miR-222-3p OSTM1 0.067264556454159 0.934147523407911 0.135803933045292 0.835648139431326 MirTarget -0.115132137926429 0.0019760606215781 NA NA NA hsa-miR-100-5p OXA1L -0.0835426508859793 0.958163253942357 0.0788388723951741 0.933795941966709 miRNAWalker2_validate -0.105412580879798 7.96540282370272e-05 NA NA NA hsa-miR-1275 P2RX7 -0.092958576443477 0.78712696322568 0.159358744213574 0.640897055819006 MirTarget -0.264855837383224 0.000219592270342575 NA NA NA hsa-miR-320c P4HA3 -0.634817265516566 0.0229406911033521 0.325918941336896 0.390968906387852 miRanda -0.277521032615814 0.00314728570796099 NA NA NA hsa-miR-143-3p PACRGL -0.0402404826858778 0.987317207979986 0.00831546604940891 0.986017473453209 MirTarget -0.126337344169006 0.000216984644410747 NA NA NA hsa-miR-222-3p PAFAH1B2 0.067264556454159 0.934147523407911 -0.216113531594318 0.731531471062173 MirTarget -0.1362820794929 0.00151700190366 NA NA NA hsa-miR-320c PALM2 -0.634817265516566 0.0229406911033521 0.148413843150233 0.554252284409809 PITA;miRanda;mirMAP -0.172072751537942 0.00944084773160535 NA NA NA hsa-miR-320c PALM2-AKAP2 -0.634817265516566 0.0229406911033521 0.253359675906971 0.736958349969104 miRanda;miRNATAP -0.103059388444184 0.0289010973043776 NA NA NA hsa-miR-100-5p PANK3 -0.0835426508859793 0.958163253942357 -0.00837257259267865 0.990211484983384 miRNAWalker2_validate -0.112238442711661 0.00174792208459905 NA NA NA hsa-miR-1275 PANX2 -0.092958576443477 0.78712696322568 0.273105374392216 0.467783438910975 MirTarget -0.181327187187639 0.01078856559502 NA NA NA hsa-miR-320c PAPLN -0.634817265516566 0.0229406911033521 -0.381076923505007 0.433871593366247 miRanda -0.162445831742901 0.0304137383651104 NA NA NA hsa-miR-1275 PAPPA -0.092958576443477 0.78712696322568 -0.118097900693866 0.764560491350577 MirTarget -0.315129569912983 2.88657785640667e-07 NA NA NA hsa-miR-222-3p PBX3 0.067264556454159 0.934147523407911 -0.0187481878899387 0.971856397128202 miRNATAP -0.3145790708152 7.31796568380877e-08 NA NA NA hsa-miR-320c PBX3 -0.634817265516566 0.0229406911033521 -0.0187481878899387 0.971856397128202 PITA;miRanda;miRNATAP -0.115258405663165 0.00724456088859532 NA NA NA hsa-miR-100-5p PCBP2 -0.0835426508859793 0.958163253942357 -0.0350157205380164 0.977623486049305 miRNAWalker2_validate -0.112119710424418 1.30845345151584e-07 NA NA NA hsa-miR-320c PCDH9 -0.634817265516566 0.0229406911033521 0.0217715061771298 0.962492632759547 miRanda;miRNATAP -0.230966979090978 0.0179529510384371 NA NA NA hsa-miR-222-3p PCDHA11 0.067264556454159 0.934147523407911 -0.259372474312614 0.715196111753079 MirTarget -0.672482474135926 0.000291435764104598 NA NA NA hsa-miR-222-3p PCDHA3 0.067264556454159 0.934147523407911 -0.289148866226989 0.561005199047614 MirTarget -0.79273332214416 3.17405090380049e-08 NA NA NA hsa-miR-222-3p PCDHA6 0.067264556454159 0.934147523407911 -0.111469361043722 0.84077722111857 MirTarget;miRNATAP -0.745513478714208 5.99074410091013e-06 NA NA NA hsa-miR-222-3p PCDHAC1 0.067264556454159 0.934147523407911 0.144297481445093 0.809469662953167 MirTarget -0.607349256254822 0.000594739485214079 NA NA NA hsa-miR-1275 PCDHGA10 -0.092958576443477 0.78712696322568 -0.00875804709465489 0.987676812371612 MirTarget -0.224917708164044 0.0416494273900498 NA NA NA hsa-miR-1275 PCDHGA12 -0.092958576443477 0.78712696322568 0.145956574857196 0.644228441673788 MirTarget -0.252529934491841 0.000144069510634738 NA NA NA hsa-miR-320c PCDHGA12 -0.634817265516566 0.0229406911033521 0.145956574857196 0.644228441673788 mirMAP -0.196197079811106 0.0199870403677507 NA NA NA hsa-miR-1275 PCDHGA2 -0.092958576443477 0.78712696322568 -0.0980419585353909 0.745744448999446 MirTarget -0.128741469751357 0.0250468526447356 NA NA NA hsa-miR-1275 PCDHGA4 -0.092958576443477 0.78712696322568 0.337474252687944 0.429836767703923 MirTarget -0.231895556390887 0.00139432260319913 NA NA NA hsa-miR-1275 PCDHGA5 -0.092958576443477 0.78712696322568 0.255549275839982 0.441286005047151 MirTarget -0.130502942218659 0.0297058830627686 NA NA NA hsa-miR-1275 PCDHGA6 -0.092958576443477 0.78712696322568 0.471382583120984 0.103134243999926 MirTarget -0.152916708209838 0.00871735485497024 NA NA NA hsa-miR-1275 PCDHGA9 -0.092958576443477 0.78712696322568 0.392056433522488 0.224771955670631 MirTarget -0.285340027594829 2.17473434413665e-05 NA NA NA hsa-miR-320c PCDHGA9 -0.634817265516566 0.0229406911033521 0.392056433522488 0.224771955670631 mirMAP -0.175597889533583 0.0406094000154972 NA NA NA hsa-miR-1275 PCDHGB6 -0.092958576443477 0.78712696322568 0.57571184309165 0.167270428082326 MirTarget -0.184832830544118 0.0405074542073335 NA NA NA hsa-miR-1275 PCDHGB7 -0.092958576443477 0.78712696322568 -0.044075776008617 0.907430408828687 MirTarget -0.300352991798334 2.31362817068791e-05 NA NA NA hsa-miR-222-3p PCMTD1 0.067264556454159 0.934147523407911 -0.0962653045248096 0.90486341314085 MirTarget -0.178114837717081 0.000244373632109014 NA NA NA hsa-miR-1275 PCSK2 -0.092958576443477 0.78712696322568 -0.114164277103873 0.871253788615164 MirTarget -0.3311100506433 0.000382165475351427 NA NA NA hsa-miR-1275 PDE1B -0.092958576443477 0.78712696322568 0.271617309880701 0.376983566819841 PITA -0.286411535356375 6.32236912474514e-06 NA NA NA hsa-miR-320c PDE2A -0.634817265516566 0.0229406911033521 -0.122831041764131 0.720985259578385 miRanda -0.150492480542935 0.0465110850538578 NA NA NA hsa-miR-103a-3p PDK4 -0.0950237190031995 0.961005442872667 -0.0989018613297405 0.878802386679582 miRNAWalker2_validate;MirTarget -0.486885214419068 0.000664640270810513 NA NA NA hsa-miR-107 PDK4 -0.0692564691973274 0.964215554949362 -0.0989018613297405 0.878802386679582 MirTarget;miRanda;miRNATAP -0.663383728990058 4.55474597678892e-05 NA NA NA hsa-miR-1226-3p PDK4 -0.151739505908207 0.574216796013786 -0.0989018613297405 0.878802386679582 MirTarget -0.292024409649969 0.000172593760335063 NA NA NA hsa-miR-142-3p PDK4 0.180010013291582 0.896814913526801 -0.0989018613297405 0.878802386679582 miRanda -0.244314834773683 0.00214678002428927 NA NA NA hsa-miR-148a-3p PDK4 0.100907912181979 0.962574545713573 -0.0989018613297405 0.878802386679582 miRNATAP -0.267553916511347 0.00763492609385656 NA NA NA hsa-miR-148a-5p PDK4 0.00159291641546666 0.998498575543413 -0.0989018613297405 0.878802386679582 mirMAP -0.396337632395598 3.44415741223919e-05 NA NA NA hsa-miR-148b-3p PDK4 -0.0835650964886092 0.940333886538049 -0.0989018613297405 0.878802386679582 miRNATAP -0.644158364545853 4.16987638049502e-06 NA NA NA hsa-miR-15a-5p PDK4 0.114954548711096 0.902368422572956 -0.0989018613297405 0.878802386679582 MirTarget;miRNATAP -0.384161951899816 0.00103713100494273 NA NA NA hsa-miR-15b-5p PDK4 -0.00689607878522391 0.994628523271082 -0.0989018613297405 0.878802386679582 MirTarget;miRNATAP -0.282746897734225 0.0104791651188707 NA NA NA hsa-miR-16-1-3p PDK4 0.336673688387428 0.263879781119291 -0.0989018613297405 0.878802386679582 MirTarget -0.425174804657213 4.44081312304046e-07 NA NA NA hsa-miR-16-5p PDK4 0.174671689106251 0.884561260745118 -0.0989018613297405 0.878802386679582 miRNAWalker2_validate;MirTarget;miRNATAP -0.323898687475885 0.00319909252169911 NA NA NA hsa-miR-181b-5p PDK4 0.0792125712512002 0.94249452124277 -0.0989018613297405 0.878802386679582 miRNATAP -0.234853443571093 0.0420524669316434 NA NA NA hsa-miR-186-5p PDK4 -0.103524789975763 0.922074318057442 -0.0989018613297405 0.878802386679582 mirMAP -0.623774383616882 3.76448312626853e-06 NA NA NA hsa-miR-2110 PDK4 -0.185073713845393 0.377700454332885 -0.0989018613297405 0.878802386679582 MirTarget -0.366854424341064 9.11503029042658e-05 NA NA NA hsa-miR-23a-3p PDK4 -0.0188223454559413 0.990631768418334 -0.0989018613297405 0.878802386679582 MirTarget -0.734512672338419 4.1111286286512e-05 NA NA NA hsa-miR-26b-5p PDK4 0.0015045790441004 0.999045618388286 -0.0989018613297405 0.878802386679582 miRNAWalker2_validate -0.2817134234432 0.031385604479346 NA NA NA hsa-miR-27a-3p PDK4 0.0343767097750227 0.981394253826582 -0.0989018613297405 0.878802386679582 MirTarget -0.645822891053103 2.90095626071442e-05 NA NA NA hsa-miR-30d-3p PDK4 -0.0335580902863248 0.922063545694521 -0.0989018613297405 0.878802386679582 MirTarget -0.359310838636904 0.000904141102520961 NA NA NA hsa-miR-330-3p PDK4 -0.0147414471416165 0.959553964589524 -0.0989018613297405 0.878802386679582 MirTarget -0.391105704610393 0.000226205964762897 NA NA NA hsa-miR-424-5p PDK4 0.146526105979442 0.876616075168222 -0.0989018613297405 0.878802386679582 MirTarget;miRNATAP -0.266014937352849 0.00106254002452574 NA NA NA hsa-miR-429 PDK4 -0.238887571847831 0.835358736540541 -0.0989018613297405 0.878802386679582 miRanda -0.393456071739868 1.83580108604689e-07 NA NA NA hsa-miR-455-5p PDK4 0.00574212460374879 0.991180561214877 -0.0989018613297405 0.878802386679582 miRanda -0.27669059439957 0.00514533530116848 NA NA NA hsa-miR-532-5p PDK4 -0.0433373569664539 0.975398214701797 -0.0989018613297405 0.878802386679582 MirTarget -0.341207337225124 0.000431462619470472 NA NA NA hsa-miR-576-5p PDK4 -0.0551664166879235 0.884235321656318 -0.0989018613297405 0.878802386679582 mirMAP -0.605993312857051 1.1874281937597e-10 NA NA NA hsa-miR-590-3p PDK4 0.0829620326684548 0.810708708264937 -0.0989018613297405 0.878802386679582 miRanda -0.320408524962837 7.14293473796299e-05 NA NA NA hsa-miR-942-5p PDK4 -0.0335057484411028 0.942305199873267 -0.0989018613297405 0.878802386679582 MirTarget -0.455623670892513 6.34831326824967e-09 NA NA NA hsa-miR-1275 PDLIM3 -0.092958576443477 0.78712696322568 0.144199316519689 0.82453458517063 MirTarget -0.280737190522656 1.17545714966856e-05 NA NA NA hsa-miR-320c PDLIM4 -0.634817265516566 0.0229406911033521 -0.0739303604801793 0.875845581840144 mirMAP -0.247718857989091 0.000870101155845086 NA NA NA hsa-miR-143-3p PDS5A -0.0402404826858778 0.987317207979986 -0.111324667246097 0.910266229405493 miRNATAP -0.107004600189549 0.000138137424992934 NA NA NA hsa-miR-1275 PDZD4 -0.092958576443477 0.78712696322568 0.110278859451428 0.744101834191299 MirTarget -0.255425295260035 0.000367592306787941 NA NA NA hsa-miR-222-3p PDZRN4 0.067264556454159 0.934147523407911 -0.491789400281551 0.36667906802044 miRNATAP -1.26045781468423 8.69448992474457e-12 NA NA NA hsa-miR-1275 PEAR1 -0.092958576443477 0.78712696322568 0.0549514884220357 0.876827291654078 MirTarget -0.209164519686493 1.4669495345164e-06 NA NA NA hsa-miR-126-5p PELI2 0.15488643986308 0.866941960712436 -0.085450363044735 0.868049463649923 mirMAP -0.219717790742832 0.0395952393219194 NA NA NA hsa-miR-151a-5p PELI2 -0.205234881234174 0.754357497530786 -0.085450363044735 0.868049463649923 miRNAWalker2_validate -0.23686005430978 0.00758007431115967 NA NA NA hsa-miR-15a-5p PELI2 0.114954548711096 0.902368422572956 -0.085450363044735 0.868049463649923 miRNATAP -0.293967648264512 0.003125705796944 NA NA NA hsa-miR-186-5p PELI2 -0.103524789975763 0.922074318057442 -0.085450363044735 0.868049463649923 mirMAP -0.334353901784669 0.00395549525081472 NA NA NA hsa-miR-222-3p PELI2 0.067264556454159 0.934147523407911 -0.085450363044735 0.868049463649923 miRNAWalker2_validate -0.268187594510168 0.00326491615202126 NA NA NA hsa-miR-29a-5p PELI2 0.0821355737825491 0.829907053101583 -0.085450363044735 0.868049463649923 mirMAP -0.337454762928535 5.74404093515078e-06 NA NA NA hsa-miR-32-3p PELI2 0.169711448232753 0.575371621381405 -0.085450363044735 0.868049463649923 mirMAP -0.182084367745599 0.00228297276856912 NA NA NA hsa-miR-335-5p PELI2 -0.0823503258190108 0.879911427250447 -0.085450363044735 0.868049463649923 miRNAWalker2_validate -0.176991276789225 0.019745832557282 NA NA NA hsa-miR-33a-3p PELI2 -0.478382609529613 0.0473796525588213 -0.085450363044735 0.868049463649923 mirMAP -0.1405001193503 0.0456064671866386 NA NA NA hsa-miR-421 PELI2 -0.226934983690969 0.526580030309737 -0.085450363044735 0.868049463649923 miRanda -0.210140069323701 0.00798821679172983 NA NA NA hsa-miR-429 PELI2 -0.238887571847831 0.835358736540541 -0.085450363044735 0.868049463649923 miRanda;miRNATAP -0.131452604660158 0.0451987936619523 NA NA NA hsa-miR-500a-5p PELI2 -0.118490009941898 0.737076200019561 -0.085450363044735 0.868049463649923 mirMAP -0.16135951103782 0.022798177639513 NA NA NA hsa-miR-539-5p PELI2 0.0779551604004214 0.810026318068051 -0.085450363044735 0.868049463649923 mirMAP -0.307669528517984 0.000664931920264497 NA NA NA hsa-miR-590-3p PELI2 0.0829620326684548 0.810708708264937 -0.085450363044735 0.868049463649923 PITA;miRanda;mirMAP -0.18243949185795 0.00824477536822743 NA NA NA hsa-miR-590-5p PELI2 -0.06413635524473 0.893491421748758 -0.085450363044735 0.868049463649923 miRanda -0.219379638314705 0.00260060467877486 NA NA NA hsa-miR-7-1-3p PELI2 -0.126737838158129 0.846416009084243 -0.085450363044735 0.868049463649923 mirMAP -0.201405973953956 0.012891040179699 NA NA NA hsa-miR-222-3p PHF2 0.067264556454159 0.934147523407911 -0.036887348906423 0.964192569968093 MirTarget;miRNATAP -0.132826444878806 4.14070033917977e-05 NA NA NA hsa-miR-222-3p PI15 0.067264556454159 0.934147523407911 -0.375814335512279 0.383661646540591 MirTarget -0.538569160890594 0.000428461416336936 NA NA NA hsa-miR-125b-5p PI4K2B 0.00744496603712985 0.994576506820994 -0.0695966473393188 0.929579581831637 miRNATAP -0.108446863383441 7.32219466052846e-05 NA NA NA hsa-miR-1275 PIAS3 -0.092958576443477 0.78712696322568 0.0443087712687111 0.944683549141109 MirTarget -0.105881504551777 2.31788392864969e-05 NA NA NA hsa-miR-125b-5p PIGF 0.00744496603712985 0.994576506820994 -0.0426466691593141 0.941895035079344 miRNAWalker2_validate;miRTarBase -0.108143107704332 6.48647568175297e-06 21703189 Overexpression of miR-125b in HCC cells decreased PIGF expression and altered the angiogenesis index liver cancer hsa-miR-1275 PIK3AP1 -0.092958576443477 0.78712696322568 0.261755614547292 0.699787565355483 MirTarget -0.226605621138803 9.06842688307649e-06 NA NA NA hsa-miR-222-3p PIK3R1 0.067264556454159 0.934147523407911 -0.0783790377508486 0.926558557648398 MirTarget -0.202803725155249 6.41878654683067e-05 NA NA NA hsa-miR-320c PILRA -0.634817265516566 0.0229406911033521 0.433844266452976 0.252028737669231 miRanda -0.171283950167106 0.0446302849423982 NA NA NA hsa-miR-143-3p PKN2 -0.0402404826858778 0.987317207979986 -0.189965007978918 0.818502173645041 MirTarget -0.104329181163214 0.00260526776854106 NA NA NA hsa-miR-1275 PKN3 -0.092958576443477 0.78712696322568 0.212293478710694 0.69047120680078 MirTarget -0.162752155100642 2.17623493154638e-06 NA NA NA hsa-miR-1275 PKNOX2 -0.092958576443477 0.78712696322568 -0.155272137607908 0.691751722649785 PITA;miRNATAP -0.254103001743841 0.00032534687775957 NA NA NA hsa-miR-1275 PLAU -0.092958576443477 0.78712696322568 0.347590899055125 0.690767789597796 MirTarget -0.173051683896361 0.000356224216379868 NA NA NA hsa-miR-143-3p PLCH1 -0.0402404826858778 0.987317207979986 -0.230859298809966 0.671704108595927 mirMAP -0.184584707414014 0.000779561170749022 NA NA NA hsa-miR-222-3p PLEKHA2 0.067264556454159 0.934147523407911 -0.275029855530816 0.741964318622101 miRNATAP -0.10046252183689 0.0452375888934014 NA NA NA hsa-miR-1275 PLEKHG2 -0.092958576443477 0.78712696322568 0.179867084519951 0.776488345901058 MirTarget -0.103722618013198 0.00248008712886187 NA NA NA hsa-miR-320c PLEKHO1 -0.634817265516566 0.0229406911033521 0.197331072470541 0.762702828106427 miRanda -0.154646226211616 0.00445347164340945 NA NA NA hsa-miR-1275 PLEKHO2 -0.092958576443477 0.78712696322568 -0.0478796139053559 0.944896788835339 MirTarget -0.182303429980047 3.49961406039317e-06 NA NA NA hsa-miR-100-5p PLK1 -0.0835426508859793 0.958163253942357 -0.0310483349109498 0.971026991889579 miRNAWalker2_validate;miRTarBase -0.199776940560773 1.06094561389214e-08 23151088;22246341;23842624;25537513;22120675;21636267 MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis ;;progression;worse prognosis;;drug resistance;tumorigenesis lung squamous cell cancer;ovarian cancer;liver cancer;breast cancer;lung cancer;cervical and endocervical cancer hsa-miR-320c PLP1 -0.634817265516566 0.0229406911033521 -0.297803647277342 0.636691727384228 miRanda -0.330328390927309 0.0291764940883316 NA NA NA hsa-miR-222-3p PLSCR4 0.067264556454159 0.934147523407911 -0.285277188161604 0.617863326862833 MirTarget -0.308298458574003 9.6647004401979e-08 NA NA NA hsa-miR-1275 PLVAP -0.092958576443477 0.78712696322568 0.00559607290778619 0.995157273577388 MirTarget -0.127619890371761 3.12823777102462e-05 NA NA NA hsa-miR-320c PNMA1 -0.634817265516566 0.0229406911033521 0.158378256828895 0.807756900080621 miRanda -0.111992311296679 0.0174279971197858 NA NA NA hsa-miR-1275 PNMAL2 -0.092958576443477 0.78712696322568 0.0895962357615344 0.758668181390978 MirTarget -0.210546652504357 0.000700524842717661 NA NA NA hsa-miR-320c PNMAL2 -0.634817265516566 0.0229406911033521 0.0895962357615344 0.758668181390978 miRanda -0.196690153688955 0.0122322884742331 NA NA NA hsa-miR-1275 PNOC -0.092958576443477 0.78712696322568 -0.021985455688931 0.968223731886601 MirTarget;PITA -0.356770484731282 0.000203516031591862 NA NA NA hsa-miR-10a-5p POPDC2 -0.103091346403293 0.963361104257071 0.229480454792977 0.441922748227177 MirTarget;miRNATAP -0.467941200174206 1.93189565932233e-07 NA NA NA hsa-miR-1275 POU2AF1 -0.092958576443477 0.78712696322568 -0.219809150963738 0.690989125245945 MirTarget -0.346941136232065 0.000606232390724891 NA NA NA hsa-miR-127-5p PPARGC1A 0.219600643898102 0.823613968184507 -0.173671059483306 0.752830856176617 PITA -0.304377256214939 0.0165426336192117 NA NA NA hsa-miR-136-5p PPARGC1A 0.15252965024613 0.758258613050847 -0.173671059483306 0.752830856176617 MirTarget;miRNATAP -0.222253214317298 0.0276914016565988 NA NA NA hsa-miR-154-3p PPARGC1A 0.161539340532407 0.45688019130916 -0.173671059483306 0.752830856176617 MirTarget;TargetScan;miRNATAP -0.214088936972166 0.0479599155860337 NA NA NA hsa-miR-199a-5p PPARGC1A 0.195305978054339 0.871425273993906 -0.173671059483306 0.752830856176617 MirTarget;PITA;miRanda;miRNATAP -0.38979645236203 0.00159298072293515 NA NA NA hsa-miR-199b-5p PPARGC1A 0.12694328853444 0.882367053531256 -0.173671059483306 0.752830856176617 MirTarget;PITA;miRanda;miRNATAP -0.305108521256453 0.0046490499491918 NA NA NA hsa-miR-218-5p PPARGC1A 0.192456846653441 0.755540918195487 -0.173671059483306 0.752830856176617 MirTarget;miRNATAP -0.224142690118457 0.0310358092400607 NA NA NA hsa-miR-30a-5p PPARGC1A -0.0440409912862041 0.978720710440791 -0.173671059483306 0.752830856176617 MirTarget;mirMAP;miRNATAP -0.373951389676948 0.0285110791998373 NA NA NA hsa-miR-409-3p PPARGC1A 0.184094194295498 0.753991080706677 -0.173671059483306 0.752830856176617 PITA -0.290333042099438 0.0362684776006821 NA NA NA hsa-miR-125b-5p PPAT 0.00744496603712985 0.994576506820994 -0.0467220907668624 0.945703050818002 miRNAWalker2_validate;MirTarget;miRNATAP -0.128207410569727 1.82758898353497e-05 NA NA NA hsa-miR-125b-5p PPIF 0.00744496603712985 0.994576506820994 0.0490725467696853 0.959800385738261 MirTarget -0.10020240922073 0.00032179406507468 NA NA NA hsa-miR-222-3p PPM1L 0.067264556454159 0.934147523407911 -0.397694877863214 0.17049525193962 mirMAP -0.206199029019685 0.00237287283686013 NA NA NA hsa-miR-125b-5p PPP1CA 0.00744496603712985 0.994576506820994 0.0158518053657923 0.988539985809994 miRTarBase -0.101718721304003 5.08711176661898e-06 25240408 MiR 125b promotes cell migration and invasion by targeting PPP1CA Rb signal pathways in gastric cancer resulting in a poor prognosis; MiR-125b was upregulated in gastric cancer tissues and cell lines and significantly promoted cellular proliferation migration and invasion by downregulating the expression of PPP1CA and upregulating Rb phosphorylation; MiR-125b functions as an oncogene by targeting downregulated PPP1CA and upregulated Rb phosphorylation in gastric cancer worse prognosis;cell migration gastric cancer hsa-miR-222-3p PPP1R12B 0.067264556454159 0.934147523407911 0.0151397064906265 0.985631633928507 mirMAP -0.613326982155884 6.71586158334128e-13 NA NA NA hsa-miR-1275 PPP1R3C -0.092958576443477 0.78712696322568 0.0151281616463537 0.965873573452748 MirTarget -0.25236671136083 0.000422661554084415 NA NA NA hsa-miR-320c PPP1R3F -0.634817265516566 0.0229406911033521 -0.0625626325696687 0.79694475402183 miRanda -0.131984658788817 0.0173767546847478 NA NA NA hsa-miR-222-3p PRDM2 0.067264556454159 0.934147523407911 -0.213483050144389 0.783545341464932 miRNATAP -0.128774848832883 0.000107579129660529 NA NA NA hsa-miR-320c PRDM6 -0.634817265516566 0.0229406911033521 0.20055333181848 0.583703993549989 miRanda -0.197962187760753 0.0326665459656602 NA NA NA hsa-miR-100-5p PRDX1 -0.0835426508859793 0.958163253942357 0.0456386318054758 0.969622733639835 miRNAWalker2_validate -0.108554417760478 3.72611543590977e-05 NA NA NA hsa-miR-125b-5p PRDX2 0.00744496603712985 0.994576506820994 0.0812746259734318 0.941363709948177 miRNAWalker2_validate -0.124454229073298 2.65008848074474e-05 22213330 Treatment with 5-Aza but not with TSA reduced the expression of miR-125b in the 125OH2D3-responsive and -resistant melanoma cell lines and in the NHM melanoma hsa-miR-1275 PRELP -0.092958576443477 0.78712696322568 -0.112469974868053 0.867974542792534 MirTarget -0.273645035495061 0.00618250479135716 NA NA NA hsa-miR-320c PRG4 -0.634817265516566 0.0229406911033521 0.381709883540671 0.390162379265138 miRanda -0.22472079947104 0.0462284977483801 NA NA NA hsa-miR-320c PRICKLE2 -0.634817265516566 0.0229406911033521 0.0180418692718569 0.969553356393566 mirMAP -0.187541898917261 0.00438167568957247 NA NA NA hsa-miR-1275 PRIMA1 -0.092958576443477 0.78712696322568 -0.760415690012521 0.191548899161081 mirMAP -0.501442237549513 1.94941295806661e-05 NA NA NA hsa-miR-10a-5p PRKAA2 -0.103091346403293 0.963361104257071 -0.13553137331871 0.799513953615924 MirTarget -0.485307367052801 0.0067774444725377 NA NA NA hsa-miR-143-3p PROSC -0.0402404826858778 0.987317207979986 -0.0880192212704332 0.917586122742837 MirTarget -0.127199600608746 0.0101529868165206 NA NA NA hsa-miR-143-3p PRPF19 -0.0402404826858778 0.987317207979986 -0.012515165773161 0.990747210325754 miRNATAP -0.110351222365795 0.000422639077133671 NA NA NA hsa-miR-1275 PRPH2 -0.092958576443477 0.78712696322568 0.382034094982325 0.24650171072 MirTarget -0.206863914118754 0.000242937696478051 NA NA NA hsa-miR-10a-5p PRRT3 -0.103091346403293 0.963361104257071 0.0377814378398074 0.851052226511402 MirTarget;miRNATAP -0.150716928981836 1.6865655837193e-05 NA NA NA hsa-miR-320c PRRX1 -0.634817265516566 0.0229406911033521 0.22543087701801 0.711652866757521 miRanda -0.245565341980188 0.00568750871972982 NA NA NA hsa-miR-320c PRRX2 -0.634817265516566 0.0229406911033521 0.439198713470691 0.187920386891451 miRanda -0.209099343183767 0.0172158724456948 NA NA NA hsa-miR-10a-5p PRTG -0.103091346403293 0.963361104257071 0.167605578197304 0.666250729400011 miRNATAP -0.548329963406467 1.2633214530841e-06 NA NA NA hsa-miR-222-3p PRTG 0.067264556454159 0.934147523407911 0.167605578197304 0.666250729400011 mirMAP -0.753867062042379 4.85634056159282e-09 NA NA NA hsa-miR-320c PRTG -0.634817265516566 0.0229406911033521 0.167605578197304 0.666250729400011 miRanda;miRNATAP -0.209383829007626 0.0282349929927013 NA NA NA hsa-miR-125b-5p PSAT1 0.00744496603712985 0.994576506820994 0.244272723857739 0.772779906370905 miRNAWalker2_validate -0.219308142609528 0.000499323813655741 NA NA NA hsa-miR-1275 PSCA -0.092958576443477 0.78712696322568 0.342787713218104 0.589636184764899 MirTarget -0.287659309653587 0.0276273141427897 NA NA NA hsa-miR-100-5p PSMA5 -0.0835426508859793 0.958163253942357 0.0225492708393826 0.981480646587403 miRNAWalker2_validate -0.138721031161225 8.69207430332961e-08 NA NA NA hsa-miR-125b-5p PSMB1 0.00744496603712985 0.994576506820994 0.00894773331743171 0.993209533768697 miRNAWalker2_validate -0.100914151799528 6.98523981125564e-05 NA NA NA hsa-miR-125b-5p PSMB8 0.00744496603712985 0.994576506820994 0.104173893796704 0.918974569178494 MirTarget -0.108681555243329 0.00129218349651532 NA NA NA hsa-miR-100-5p PSMG2 -0.0835426508859793 0.958163253942357 -0.0590327400452706 0.94146806005306 miRNAWalker2_validate -0.138057201135175 2.97424982514367e-07 NA NA NA hsa-miR-320c PTGER3 -0.634817265516566 0.0229406911033521 0.00959431629424767 0.982520443211112 miRNATAP -0.28444539892586 0.00849771623932605 NA NA NA hsa-miR-1275 PTHLH -0.092958576443477 0.78712696322568 -0.0457916072066167 0.88039158641422 MirTarget;PITA -0.282288577759908 8.57473109278797e-06 NA NA NA hsa-miR-100-5p PTP4A1 -0.0835426508859793 0.958163253942357 -0.0243327739863037 0.98201505079887 miRNAWalker2_validate -0.164781571614645 7.38456891520171e-07 NA NA NA hsa-miR-1275 PTPN14 -0.092958576443477 0.78712696322568 0.0621466027593454 0.867966003160824 MirTarget -0.127774457740521 0.00011955101977459 NA NA NA hsa-miR-320c PTPRS -0.634817265516566 0.0229406911033521 -0.524421260704145 0.312937369012836 miRanda -0.202074296786543 0.0147603925092002 NA NA NA hsa-miR-10a-5p PTPRT -0.103091346403293 0.963361104257071 -0.344345311442128 0.538320850320105 miRNAWalker2_validate;mirMAP -0.397124694803249 0.0029100405064358 NA NA NA hsa-miR-320c PTRF -0.634817265516566 0.0229406911033521 0.210693920720519 0.83454612978802 mirMAP;miRNATAP -0.138196927156619 0.0123824667963811 NA NA NA hsa-miR-125b-5p PYCRL 0.00744496603712985 0.994576506820994 0.00778103767904081 0.991173533584173 mirMAP -0.130457693827841 0.00305945205965112 NA NA NA hsa-miR-10a-5p PYGL -0.103091346403293 0.963361104257071 0.385912913427576 0.60418123390313 miRNAWalker2_validate -0.233552966557661 0.0194032412824598 NA NA NA hsa-miR-1275 QKI -0.092958576443477 0.78712696322568 0.0766574767067612 0.908057533664055 MirTarget;PITA -0.182499504048025 6.07859427635617e-05 NA NA NA hsa-miR-222-3p QKI 0.067264556454159 0.934147523407911 0.0766574767067612 0.908057533664055 miRNAWalker2_validate -0.501807052047758 9.5738232380987e-11 NA NA NA hsa-miR-320c RAB23 -0.634817265516566 0.0229406911033521 0.120853428405446 0.850104735186795 miRanda -0.11623109766164 0.0020857231474491 NA NA NA hsa-miR-1275 RAB3B -0.092958576443477 0.78712696322568 0.0380609919612735 0.932048517722007 MirTarget -0.378351278357006 1.09194076696297e-05 NA NA NA hsa-miR-1275 RADIL -0.092958576443477 0.78712696322568 0.291638208509347 0.479914252973488 mirMAP -0.257647951435197 0.00108222164617435 NA NA NA hsa-miR-222-3p RALGAPA1 0.067264556454159 0.934147523407911 0.0025017715439013 0.996709582155044 miRNATAP -0.130007814268047 0.0011326478276032 NA NA NA hsa-miR-143-3p RALGPS1 -0.0402404826858778 0.987317207979986 0.0651449886807267 0.916197518181147 mirMAP -0.136870565994503 0.0046925844440811 NA NA NA hsa-miR-100-5p RARS -0.0835426508859793 0.958163253942357 0.0106406952307765 0.990473882578057 miRNAWalker2_validate -0.109367791964212 3.7619677584778e-08 NA NA NA hsa-miR-320c RASA4 -0.634817265516566 0.0229406911033521 -0.0783366798089715 0.868393329480582 miRanda -0.101517085295959 0.0466469044257211 NA NA NA hsa-miR-1275 RASGRP4 -0.092958576443477 0.78712696322568 0.0227634763892532 0.943069073039684 MirTarget -0.290074813600451 5.487239434527e-06 NA NA NA hsa-miR-320c RASSF8 -0.634817265516566 0.0229406911033521 0.0688343267301019 0.875862850429506 miRanda;miRNATAP -0.161297430415281 0.0381540891333301 NA NA NA hsa-miR-100-5p RAVER2 -0.0835426508859793 0.958163253942357 -0.204938944886525 0.787453336441257 MirTarget;miRNATAP -0.127522968882618 0.000920907833595536 NA NA NA hsa-miR-10a-5p RBMS3 -0.103091346403293 0.963361104257071 0.0568069711814005 0.875319042559465 MirTarget -0.484608746684391 1.78474439859502e-07 NA NA NA hsa-miR-1275 RBMS3 -0.092958576443477 0.78712696322568 0.0568069711814005 0.875319042559465 MirTarget -0.203559607791085 0.00105685672792964 NA NA NA hsa-miR-320c RCAN2 -0.634817265516566 0.0229406911033521 -0.0501684719100441 0.911740394223935 miRanda -0.119941953007673 0.0404787888287463 NA NA NA hsa-miR-222-3p RECK 0.067264556454159 0.934147523407911 0.107025452835489 0.788963394458971 miRNAWalker2_validate;miRTarBase -0.526531583730316 3.30378835851354e-12 22321642;26364844 Increased miR 222 in H pylori associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK; Mechanistically we identified RECK as a novel target of miR-222 and also confirmed their relationship by the inverse correlation of mRNA expression ex vivo; Furthermore we found that RNA interference silencing of RECK can mimic the oncogenic effects of miR-222; Collectively H pylori may function as an initiator in the process of carcinogenesis by up-regulating miR-222 which further participates in the progression of cancer by promoting proliferation and inhibiting RECK;miR 221 and miR 222 Simultaneously Target RECK and Regulate Growth and Invasion of Gastric Cancer Cells; Dual luciferase assay was performed to verify putative binding between miR-221 or miR-222 and RECK; MiR-221 and miR-222 can bind the same sequence of RECK 3'UTR thereby modulating its expression; Through simultaneous regulation over RECK miR-221 and miR-222 can promote gastric cancer cell growth and invasion progression;tumorigenesis; gastric cancer;gastric cancer hsa-miR-320c RECK -0.634817265516566 0.0229406911033521 0.107025452835489 0.788963394458971 miRanda -0.115496453406665 0.0425507820180168 NA NA NA hsa-miR-10a-5p REEP2 -0.103091346403293 0.963361104257071 0.0474197298548982 0.86855304496325 mirMAP -0.566916067310689 1.17855646446948e-10 NA NA NA hsa-miR-10a-5p RELN -0.103091346403293 0.963361104257071 -0.721286234284295 0.156639787170793 miRNAWalker2_validate -0.725376266055571 7.04400916464155e-06 NA NA NA hsa-miR-1275 RERG -0.092958576443477 0.78712696322568 -0.214589390591989 0.561668440015633 MirTarget -0.266491393813028 0.000197386488239608 NA NA NA hsa-miR-222-3p REV3L 0.067264556454159 0.934147523407911 -0.203027389561772 0.746197256945875 miRNATAP -0.243197007317201 1.04983673600422e-10 NA NA NA hsa-miR-125b-5p RFC5 0.00744496603712985 0.994576506820994 0.0126272267794336 0.984202304192779 MirTarget -0.166452525313811 5.32296224472876e-08 NA NA NA hsa-miR-320c RFTN1 -0.634817265516566 0.0229406911033521 -0.0646315800103938 0.92403161052815 miRanda -0.117650366144855 0.0324849131506363 NA NA NA hsa-miR-548o-3p RFX2 0.0471744420039305 0.839937385468575 -0.260685963355962 0.537242652506507 MirTarget -0.188253642116301 0.00196101756405587 NA NA NA hsa-miR-125b-5p RHOV 0.00744496603712985 0.994576506820994 -0.0394098918381602 0.932072794528046 miRNAWalker2_validate -0.285888897243132 0.0011333142124771 NA NA NA hsa-miR-320c RIC3 -0.634817265516566 0.0229406911033521 0.103753785478079 0.852975893490951 mirMAP -0.334675171338538 0.0033282599735213 NA NA NA hsa-miR-1275 RIMS4 -0.092958576443477 0.78712696322568 0.176831884021844 0.729065027873346 MirTarget;mirMAP -0.182397838862527 0.0344757395138942 NA NA NA hsa-miR-320c RIMS4 -0.634817265516566 0.0229406911033521 0.176831884021844 0.729065027873346 PITA;mirMAP;miRNATAP -0.233491219192746 0.0311694677041529 NA NA NA hsa-miR-125b-5p RNASEH2A 0.00744496603712985 0.994576506820994 0.0354096472421386 0.962646092875297 miRNAWalker2_validate -0.130455937244442 7.3350654960023e-05 NA NA NA hsa-miR-222-3p RND2 0.067264556454159 0.934147523407911 0.210931320939383 0.588788701396683 miRNATAP -0.500615015182398 3.95892620621753e-05 NA NA NA hsa-miR-10a-5p RNF112 -0.103091346403293 0.963361104257071 0.24027452361907 0.43639951996181 MirTarget -0.175438213441301 0.0370538554395121 NA NA NA hsa-miR-143-3p RNF114 -0.0402404826858778 0.987317207979986 -0.0184773566344489 0.98575100512769 MirTarget -0.120546735241222 0.00566754781124767 NA NA NA hsa-miR-1275 RNF125 -0.092958576443477 0.78712696322568 0.0590260126178088 0.905237586564365 MirTarget -0.215272572793914 4.27665574352856e-05 NA NA NA hsa-miR-1275 RNF144A -0.092958576443477 0.78712696322568 0.0282080636692035 0.961720920424539 MirTarget -0.151292304824893 0.000322336198209064 NA NA NA hsa-miR-320c RNF150 -0.634817265516566 0.0229406911033521 -0.410560106108788 0.358867570571727 miRanda;miRNATAP -0.227570350126014 0.0479854564150293 NA NA NA hsa-miR-222-3p RNF152 0.067264556454159 0.934147523407911 0.23223554803471 0.415590931508705 mirMAP -0.243731713427406 0.0148839397283138 NA NA NA hsa-miR-10a-5p RNF213 -0.103091346403293 0.963361104257071 -0.11172770755698 0.919053015429121 miRNAWalker2_validate -0.177465515872525 0.000360235657754617 NA NA NA hsa-miR-1275 ROR1 -0.092958576443477 0.78712696322568 0.184465148890295 0.634357843267407 MirTarget -0.330973140966345 5.08531159245789e-05 NA NA NA hsa-miR-10a-5p RORA -0.103091346403293 0.963361104257071 -0.20681216774055 0.623296631585677 MirTarget;miRNATAP -0.307136421605802 5.19625876049456e-05 NA NA NA hsa-miR-100-5p RPLP1 -0.0835426508859793 0.958163253942357 0.0692219577193196 0.962215877853302 miRNAWalker2_validate -0.102262394841364 0.00130485351764656 NA NA NA hsa-miR-100-5p RPS15 -0.0835426508859793 0.958163253942357 0.0651264877252888 0.956501180320887 miRNAWalker2_validate -0.110705216551504 0.00209464206270987 NA NA NA hsa-miR-125b-5p RPS6KA1 0.00744496603712985 0.994576506820994 -0.0495502471041371 0.959654711628623 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.104692452263428 0.00316337364320319 NA NA NA hsa-miR-125b-5p RREB1 0.00744496603712985 0.994576506820994 -0.216393744393063 0.802465305369513 miRNATAP -0.103557616426253 4.70312943362127e-05 NA NA NA hsa-miR-100-5p RRM2 -0.0835426508859793 0.958163253942357 -0.0225102941588808 0.981387034234086 miRNAWalker2_validate -0.249955735053857 1.22960891536388e-09 NA NA NA hsa-miR-222-3p RSBN1L 0.067264556454159 0.934147523407911 -0.060416671824485 0.920926724228981 MirTarget;miRNATAP -0.108137999460218 0.000200746629289599 NA NA NA hsa-miR-1275 RSPO2 -0.092958576443477 0.78712696322568 -0.313711927762522 0.559188292939865 MirTarget -0.306979697776312 0.0010253414536275 NA NA NA hsa-miR-1275 RTBDN -0.092958576443477 0.78712696322568 -0.300804613747372 0.65650602282522 MirTarget -0.318746831937248 0.00128727270994133 NA NA NA hsa-miR-1275 RTN4RL2 -0.092958576443477 0.78712696322568 -0.0917740543604801 0.764194983379858 mirMAP -0.12987366139592 0.0256572142392747 NA NA NA hsa-miR-222-3p RUNX1T1 0.067264556454159 0.934147523407911 -0.25681184334399 0.478103773302059 miRNATAP -1.03243562972893 6.3440679178826e-17 NA NA NA hsa-miR-1275 RUNX3 -0.092958576443477 0.78712696322568 -0.0507720743191951 0.931427440560896 MirTarget -0.153439433903533 0.00473430700909597 NA NA NA hsa-miR-1275 S1PR2 -0.092958576443477 0.78712696322568 -0.0444580679937747 0.915329442667468 MirTarget -0.119180175757926 2.74573027534555e-05 NA NA NA hsa-miR-320c SALL2 -0.634817265516566 0.0229406911033521 -0.086975000176321 0.786145213599672 miRanda;miRNATAP -0.184299327676599 0.0215645604327344 NA NA NA hsa-miR-320c SAMD14 -0.634817265516566 0.0229406911033521 0.173327252600326 0.4110148757173 mirMAP -0.119698683203786 0.0259113341557896 NA NA NA hsa-miR-1275 SAMHD1 -0.092958576443477 0.78712696322568 0.00597266216849146 0.993292050718761 MirTarget -0.142535892450743 0.000653682885242371 NA NA NA hsa-miR-222-3p SAP30L 0.067264556454159 0.934147523407911 -0.0360359374795864 0.961330394583148 miRNAWalker2_validate -0.128021122196159 1.76552542855641e-05 NA NA NA hsa-miR-1275 SASH3 -0.092958576443477 0.78712696322568 0.00985972625652787 0.984384296294478 MirTarget -0.24877369832949 1.19527554246173e-05 NA NA NA hsa-miR-10a-5p SBK1 -0.103091346403293 0.963361104257071 0.045165756263164 0.927424588074963 mirMAP -0.245965543966711 0.0404992553309069 NA NA NA hsa-miR-1275 SCARA3 -0.092958576443477 0.78712696322568 0.0318720290000352 0.945865693475783 MirTarget -0.197225248359853 0.000662690946761801 NA NA NA hsa-miR-320c SCHIP1 -0.634817265516566 0.0229406911033521 0.181259839145723 0.619529865357464 miRanda -0.160105590918705 0.00374495374372272 NA NA NA hsa-miR-125b-5p SCLY 0.00744496603712985 0.994576506820994 -0.0392917822198529 0.95214630980992 MirTarget -0.117949362859102 4.89754222397105e-05 NA NA NA hsa-miR-222-3p SCN11A 0.067264556454159 0.934147523407911 0.128837841253969 0.826554668608543 MirTarget -0.736946498171194 3.99013371639328e-08 NA NA NA hsa-miR-1275 SCN2B -0.092958576443477 0.78712696322568 -0.371759073440238 0.514336554906821 mirMAP -0.272323662279042 0.00729557055645645 NA NA NA hsa-miR-320c SCN2B -0.634817265516566 0.0229406911033521 -0.371759073440238 0.514336554906821 mirMAP -0.272923411170953 0.0328546084433568 NA NA NA hsa-miR-320c SCUBE3 -0.634817265516566 0.0229406911033521 0.824910829489357 0.0394438672821974 miRanda -0.218516078126164 0.0443771411380653 NA NA NA hsa-miR-10a-5p SDC3 -0.103091346403293 0.963361104257071 -0.307267307979551 0.734921291840799 mirMAP -0.102661776936357 0.0342136913218124 NA NA NA hsa-miR-125b-5p SDHB 0.00744496603712985 0.994576506820994 -0.0091154177238888 0.991905573067216 miRNAWalker2_validate -0.130780364385156 2.23809825935694e-06 NA NA NA hsa-miR-222-3p SELE 0.067264556454159 0.934147523407911 -0.0246387786319637 0.953670171883546 miRNAWalker2_validate -0.647354279747094 1.18836442077838e-05 NA NA NA hsa-miR-320c SEMA3A -0.634817265516566 0.0229406911033521 -0.0151478227438391 0.979143444794763 MirTarget;PITA;miRanda;miRNATAP -0.21860575871758 0.0114875872684588 NA NA NA hsa-miR-222-3p SEMA3C 0.067264556454159 0.934147523407911 -0.146194239463267 0.871489382095978 MirTarget -0.356243167704466 5.54590177375438e-05 NA NA NA hsa-miR-1275 SEMA3D -0.092958576443477 0.78712696322568 0.108714182472411 0.820366961851515 MirTarget -0.318022416943835 0.00139578733101439 NA NA NA hsa-miR-320c SEMA3D -0.634817265516566 0.0229406911033521 0.108714182472411 0.820366961851515 PITA -0.251617707567065 0.0456935358622923 NA NA NA hsa-miR-125b-5p SEMA4B 0.00744496603712985 0.994576506820994 0.0448419819869583 0.963225098223419 MirTarget -0.126314133555141 0.00496777002127013 NA NA NA hsa-miR-222-3p SEMA5A 0.067264556454159 0.934147523407911 -0.297406037286307 0.726792412667578 mirMAP -0.366869944803248 0.000476301806371301 NA NA NA hsa-miR-1275 SEMA6B -0.092958576443477 0.78712696322568 0.146731880655384 0.761350910824314 MirTarget -0.237450204456678 4.1032099214255e-08 NA NA NA hsa-miR-222-3p SENP7 0.067264556454159 0.934147523407911 -0.105282691162983 0.823261096682582 MirTarget -0.116139297496031 0.00433986432746434 NA NA NA hsa-miR-100-5p SEPSECS -0.0835426508859793 0.958163253942357 0.102921542118343 0.859653276993334 miRNAWalker2_validate -0.111593152452533 0.000182413812086445 NA NA NA hsa-miR-125b-5p SEPSECS 0.00744496603712985 0.994576506820994 0.102921542118343 0.859653276993334 miRNATAP -0.115601018530266 8.34071513551699e-05 NA NA NA hsa-miR-1275 SERPINB7 -0.092958576443477 0.78712696322568 0.447843995141262 0.551295692197716 MirTarget -0.460958713842602 8.3659537905342e-05 NA NA NA hsa-miR-320c SERPINF1 -0.634817265516566 0.0229406911033521 0.0744135467285343 0.929129543623415 miRanda -0.148605716374464 0.0364721292032905 NA NA NA hsa-miR-320c SERPING1 -0.634817265516566 0.0229406911033521 0.125349240288192 0.896519617125149 MirTarget;miRanda -0.154486335962775 0.0423720869084638 NA NA NA hsa-miR-222-3p SERTAD4 0.067264556454159 0.934147523407911 -0.183155885009227 0.608976356753325 miRNAWalker2_validate -0.940013971212268 1.18008114223928e-13 NA NA NA hsa-miR-100-5p SET -0.0835426508859793 0.958163253942357 -0.00271756184492666 0.998216659610704 miRNAWalker2_validate -0.104056686686811 6.59587454679001e-07 NA NA NA hsa-miR-1275 SFRP1 -0.092958576443477 0.78712696322568 -0.187308759276927 0.721027179302842 MirTarget -0.510540537016915 4.91642034813301e-06 NA NA NA hsa-miR-143-3p SFXN1 -0.0402404826858778 0.987317207979986 0.014811670341019 0.985027359219255 MirTarget -0.158021246108975 0.000574288567233541 NA NA NA hsa-miR-320c SGCA -0.634817265516566 0.0229406911033521 -0.254586482305629 0.592495728426639 miRanda -0.335302012876111 0.00843327187610999 NA NA NA hsa-miR-320c SGCE -0.634817265516566 0.0229406911033521 0.0553517838722595 0.895163825298002 miRanda -0.14980556841349 0.0316460999842242 NA NA NA hsa-miR-320c SGIP1 -0.634817265516566 0.0229406911033521 0.0966374482281551 0.746063121030358 miRanda -0.2135501071514 0.00128049804525563 NA NA NA hsa-miR-1275 SH2D3C -0.092958576443477 0.78712696322568 0.107838713274226 0.814940413920155 MirTarget -0.181241770276059 1.87585458650259e-06 NA NA NA hsa-miR-222-3p SHISA2 0.067264556454159 0.934147523407911 -0.162933359913525 0.689763678291041 miRNAWalker2_validate -0.744538008082085 6.04223338676091e-09 NA NA NA hsa-miR-1275 SHISA3 -0.092958576443477 0.78712696322568 0.0831822199249254 0.853467708350838 MirTarget -0.229223554671733 0.0160089808834733 NA NA NA hsa-miR-320c SHISA9 -0.634817265516566 0.0229406911033521 0.190988621922098 0.784555347450382 mirMAP -0.584150568450478 0.0013928967628542 NA NA NA hsa-miR-125b-5p SHMT1 0.00744496603712985 0.994576506820994 0.0621865454823354 0.932463040523919 miRNAWalker2_validate -0.137411500725516 0.000168358788039628 NA NA NA hsa-miR-1275 SIDT1 -0.092958576443477 0.78712696322568 -0.531072893986404 0.344223985735898 MirTarget -0.152440470602985 0.00849296023944276 NA NA NA hsa-miR-125b-5p SIRT7 0.00744496603712985 0.994576506820994 0.216609829538726 0.750271473349075 MirTarget -0.106409243089868 0.000282600578317496 24512851;24396870;23079745 Hsa miR 125b suppresses bladder cancer development by down regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1; Hsa-miR-125b mimic downregulated whereas hsa-miR-125b inhibitor upregulated the expression of SIRT7 and MALAT1; Upregulation of hsa-miR-125b or downregulation of SIRT7 inhibited proliferation motility and increased apoptosis; These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1;Hsa miR 125b suppresses bladder cancer development by down regulating oncogene SIRT7 and oncogenic long non coding RNA MALAT1; Hsa-miR-125b mimic down-regulated whereas hsa-miR-125b inhibitor up-regulated the expression of SIRT7 and MALAT1; Up-regulation of hsa-miR-125b or down-regulation of SIRT7 inhibited proliferation motility and increased apoptosis; These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1;Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region; A regulatory loop is proposed whereby SIRT7 inhibits transcriptional activation of p21WAF1/Cip1 by way of repression of miR-125a-5p and miR-125b motility;motility; bladder cancer;bladder cancer;liver cancer hsa-miR-1275 SLA2 -0.092958576443477 0.78712696322568 -0.0672414749010282 0.816834377060646 MirTarget -0.156558187628163 0.010510532868782 NA NA NA hsa-miR-1275 SLAMF8 -0.092958576443477 0.78712696322568 0.101575588071992 0.854536598774853 MirTarget -0.304834297865959 7.82133267259012e-07 NA NA NA hsa-miR-1275 SLC11A1 -0.092958576443477 0.78712696322568 0.350406630815257 0.455227941877294 PITA;miRNATAP -0.34634706900199 2.14136347439775e-07 NA NA NA hsa-miR-320c SLC11A1 -0.634817265516566 0.0229406911033521 0.350406630815257 0.455227941877294 miRanda -0.250642396620279 0.00342957446523514 NA NA NA hsa-miR-320c SLC16A1 -0.634817265516566 0.0229406911033521 0.00854154404724117 0.993145489586014 MirTarget;miRanda -0.116164203983594 0.0151544403782695 NA NA NA hsa-miR-125b-5p SLC19A1 0.00744496603712985 0.994576506820994 0.0983273967850833 0.891313420076306 miRNAWalker2_validate -0.111936983701365 0.00111315055466536 NA NA NA hsa-miR-10a-5p SLC23A2 -0.103091346403293 0.963361104257071 -0.199804754093403 0.753229358723955 mirMAP -0.167079126313581 0.000267888016892634 NA NA NA hsa-miR-125b-5p SLC25A10 0.00744496603712985 0.994576506820994 0.0928064886866986 0.917352667641493 mirMAP -0.177440790026325 3.63633067554526e-06 NA NA NA hsa-miR-143-3p SLC25A15 -0.0402404826858778 0.987317207979986 0.0207945874927375 0.977759084729839 MirTarget -0.140628693038322 0.00320195005956639 NA NA NA hsa-miR-125b-5p SLC26A6 0.00744496603712985 0.994576506820994 -0.0338557694320007 0.96617391540084 MirTarget -0.100835225303853 0.00644484115038591 NA NA NA hsa-miR-320c SLC2A14 -0.634817265516566 0.0229406911033521 0.217396606848713 0.431574704553825 miRanda -0.16429783371799 0.0201710862269358 NA NA NA hsa-miR-1275 SLC2A3 -0.092958576443477 0.78712696322568 0.27000340556993 0.707982618066821 miRNATAP -0.233862584798909 1.02438684757481e-05 NA NA NA hsa-miR-320c SLC2A3 -0.634817265516566 0.0229406911033521 0.27000340556993 0.707982618066821 miRanda -0.188435054905989 0.00523117717050066 NA NA NA hsa-miR-125b-5p SLC39A9 0.00744496603712985 0.994576506820994 0.0296400369953824 0.974469010225109 MirTarget -0.107641551229918 1.19697853222891e-07 NA NA NA hsa-miR-125b-5p SLC4A4 0.00744496603712985 0.994576506820994 0.655000011955833 0.286772014622164 miRNATAP -0.313296475610138 0.0446681921693344 NA NA NA hsa-miR-222-3p SLC4A7 0.067264556454159 0.934147523407911 -0.0711904603280571 0.910225059856847 MirTarget -0.157894460854553 0.000560850664093875 NA NA NA hsa-miR-320c SLC6A17 -0.634817265516566 0.0229406911033521 0.424639745579692 0.334711098466994 mirMAP -0.208104242829267 0.0207505528692437 NA NA NA hsa-miR-320c SLC7A14 -0.634817265516566 0.0229406911033521 0.191897292952975 0.781696421910818 miRNATAP -0.300863375248393 0.0165129630989343 NA NA NA hsa-miR-1275 SLC8A1 -0.092958576443477 0.78712696322568 -0.134024445254716 0.785236672472564 MirTarget -0.194495647955688 4.25096920796629e-06 NA NA NA hsa-miR-222-3p SLFN11 0.067264556454159 0.934147523407911 0.0554768374060957 0.920618853293327 miRNAWalker2_validate -0.491084297945191 2.39708175962717e-07 NA NA NA hsa-miR-1275 SLFN5 -0.092958576443477 0.78712696322568 0.0596252929523753 0.917392086992837 MirTarget -0.228299461531861 6.59784739047878e-06 NA NA NA hsa-miR-1275 SLIT3 -0.092958576443477 0.78712696322568 0.0184327044988755 0.973132535216864 mirMAP -0.278661321382004 0.000117004758819377 NA NA NA hsa-miR-320c SLITRK3 -0.634817265516566 0.0229406911033521 -0.0146292156794665 0.982857518783822 PITA;miRanda;miRNATAP -0.310030365371196 0.0184956453876482 NA NA NA hsa-miR-143-3p SMARCD2 -0.0402404826858778 0.987317207979986 0.119400347698751 0.909710695175383 miRNATAP -0.153302629568376 1.85712375567206e-05 NA NA NA hsa-miR-125b-5p SMC2 0.00744496603712985 0.994576506820994 -0.103865006292351 0.896009231548486 miRNAWalker2_validate -0.15719579126852 1.95042599904325e-08 NA NA NA hsa-miR-10a-5p SMTNL2 -0.103091346403293 0.963361104257071 -0.205608257681993 0.64837523102261 MirTarget -0.556979445940203 0.000126262449605195 NA NA NA hsa-miR-320c SMYD1 -0.634817265516566 0.0229406911033521 0.375878266628632 0.570030837320469 miRanda -0.338208588741131 0.0119359123071106 NA NA NA hsa-miR-320c SNAI2 -0.634817265516566 0.0229406911033521 0.0276479353882748 0.948430703003399 miRanda -0.174406146504744 0.00321056492368298 NA NA NA hsa-miR-1275 SNPH -0.092958576443477 0.78712696322568 0.254815372390941 0.474204933813213 MirTarget -0.161628616939042 0.00625604915900424 NA NA NA hsa-miR-320c SORBS1 -0.634817265516566 0.0229406911033521 -0.179361321982577 0.832802535193118 mirMAP -0.169816545166979 0.017331690888283 NA NA NA hsa-miR-320c SORCS1 -0.634817265516566 0.0229406911033521 -0.104951987492108 0.856121319639488 miRNATAP -0.384356182136891 0.00492821063503663 NA NA NA hsa-miR-10a-5p SORCS2 -0.103091346403293 0.963361104257071 -0.271397838692165 0.489593568184517 mirMAP -0.49893007201157 1.31303630435947e-06 NA NA NA hsa-miR-1275 SORCS2 -0.092958576443477 0.78712696322568 -0.271397838692165 0.489593568184517 mirMAP -0.175197593748622 0.011225250946882 NA NA NA hsa-miR-320c SORCS2 -0.634817265516566 0.0229406911033521 -0.271397838692165 0.489593568184517 MirTarget;miRanda -0.187225096620476 0.0313671091793764 NA NA NA hsa-miR-222-3p SORT1 0.067264556454159 0.934147523407911 -0.293029117059411 0.769992942444331 miRNAWalker2_validate -0.141385223711603 0.00265155781397929 NA NA NA hsa-miR-1275 SOX10 -0.092958576443477 0.78712696322568 0.361608425545683 0.570808646777486 MirTarget -0.533239222897393 1.91924199952789e-06 NA NA NA hsa-miR-320c SOX11 -0.634817265516566 0.0229406911033521 0.624147661772989 0.0693778524540237 PITA;mirMAP -0.188556356494868 0.0372914068921945 NA NA NA hsa-miR-10a-5p SPARC -0.103091346403293 0.963361104257071 0.367054178084226 0.792473340527873 miRNAWalker2_validate -0.398355320835883 3.75563933513319e-07 NA NA NA hsa-miR-1275 SPARC -0.092958576443477 0.78712696322568 0.367054178084226 0.792473340527873 MirTarget -0.239498922822221 3.7468774133504e-06 NA NA NA hsa-miR-125b-5p SPDEF 0.00744496603712985 0.994576506820994 0.610242326262871 0.362569537325567 mirMAP -0.329427564747283 0.0237305237339418 NA NA NA hsa-miR-1275 SPN -0.092958576443477 0.78712696322568 -0.121162447086257 0.78475774619038 mirMAP -0.162504463494964 0.00492619644628267 NA NA NA hsa-miR-1275 SPOCD1 -0.092958576443477 0.78712696322568 0.568705353966937 0.0974842662003784 mirMAP -0.245128299428692 7.90833938519868e-05 NA NA NA hsa-miR-1275 SPOCK1 -0.092958576443477 0.78712696322568 0.736060371837319 0.261224753272182 MirTarget -0.431856345297975 7.46864838560709e-06 NA NA NA hsa-miR-1275 SPRR1B -0.092958576443477 0.78712696322568 0.179707948816049 0.831763712795646 MirTarget -0.35587727266586 0.013724447246657 NA NA NA hsa-miR-100-5p SRD5A3 -0.0835426508859793 0.958163253942357 -0.11697870685241 0.858156644945405 miRNAWalker2_validate -0.121973740596271 0.0119270173458526 NA NA NA hsa-miR-1275 SRGAP2 -0.092958576443477 0.78712696322568 0.0862001317803838 0.891157590519337 MirTarget -0.136102443355063 9.44416141920042e-06 NA NA NA hsa-miR-10a-5p SSPN -0.103091346403293 0.963361104257071 0.172947800148135 0.745564804031676 MirTarget -0.349024229363043 1.02925787682905e-05 NA NA NA hsa-miR-320c SSPN -0.634817265516566 0.0229406911033521 0.172947800148135 0.745564804031676 miRanda -0.153966371992584 0.0203805628144771 NA NA NA hsa-miR-125b-5p SSR3 0.00744496603712985 0.994576506820994 0.0508937341619653 0.960335045529884 miRNAWalker2_validate -0.104694370129056 8.00446253947047e-06 NA NA NA hsa-miR-10a-5p ST3GAL1 -0.103091346403293 0.963361104257071 0.262224599363094 0.715084657891741 mirMAP -0.302474018939005 0.000364993516797836 NA NA NA hsa-miR-320c ST3GAL6 -0.634817265516566 0.0229406911033521 0.292098351988822 0.248337113855172 miRanda -0.169648465563814 0.010724775301228 NA NA NA hsa-miR-1275 STAC -0.092958576443477 0.78712696322568 0.155814317842874 0.735643923482713 MirTarget -0.384732079310082 7.09304614098257e-07 NA NA NA hsa-miR-1275 STIM2 -0.092958576443477 0.78712696322568 -0.0464986953077515 0.945674842138315 MirTarget -0.102618733888185 0.000175900717617003 NA NA NA hsa-miR-320c STK32B -0.634817265516566 0.0229406911033521 -0.0646280067970509 0.827283712019202 MirTarget;miRanda -0.149082515199136 0.0358912075173099 NA NA NA hsa-miR-320c STK33 -0.634817265516566 0.0229406911033521 0.475663983139122 0.395571646902248 miRanda -0.320245032577475 0.0288640500356086 NA NA NA hsa-miR-1275 STON1 -0.092958576443477 0.78712696322568 -0.196118131303443 0.682808578156595 MirTarget -0.301013166031114 1.84942294729427e-06 NA NA NA hsa-miR-222-3p STOX2 0.067264556454159 0.934147523407911 0.0601889010082015 0.899561476864728 miRNAWalker2_validate -0.728696684869657 2.30118187453317e-10 NA NA NA hsa-miR-125b-5p STRN3 0.00744496603712985 0.994576506820994 0.0340637439451505 0.958276731322943 miRNAWalker2_validate -0.122608351000285 1.20646438458824e-06 NA NA NA hsa-miR-1275 STS -0.092958576443477 0.78712696322568 -0.11378471859011 0.856725295985247 MirTarget -0.136545055824062 0.00219754965229545 NA NA NA hsa-miR-320c SULT4A1 -0.634817265516566 0.0229406911033521 -0.31291605761232 0.652243573642701 miRanda -0.36498034917636 0.0163112222844289 NA NA NA hsa-miR-222-3p SUN2 0.067264556454159 0.934147523407911 -0.152964354502031 0.879190324261997 miRNAWalker2_validate;miRNATAP -0.10805727046492 0.00619218224143309 NA NA NA hsa-miR-1275 SUSD4 -0.092958576443477 0.78712696322568 -0.345144486459863 0.427821726806341 MirTarget -0.241098090709395 0.000878703078085261 NA NA NA hsa-miR-222-3p SUSD5 0.067264556454159 0.934147523407911 0.227975754488258 0.533906135219498 miRNATAP -0.980362639094207 1.59970019005667e-14 NA NA NA hsa-miR-222-3p SV2A 0.067264556454159 0.934147523407911 -0.00499862202276447 0.987566576640414 miRNAWalker2_validate -0.485947759591634 5.67072314781485e-08 NA NA NA hsa-miR-320c SV2A -0.634817265516566 0.0229406911033521 -0.00499862202276447 0.987566576640414 miRanda -0.163044862195566 0.0133018629996282 NA NA NA hsa-miR-1275 SYNGR1 -0.092958576443477 0.78712696322568 0.249283529993461 0.489123847761363 mirMAP -0.275302992509414 7.35267313673782e-05 NA NA NA hsa-miR-320c SYNM -0.634817265516566 0.0229406911033521 -0.215551456257776 0.755562136933476 miRanda -0.236387327037916 0.0398755005434771 NA NA NA hsa-miR-10a-5p SYNPO -0.103091346403293 0.963361104257071 -0.0115056889427718 0.9895184190644 mirMAP -0.278027138469778 3.8097792272992e-07 NA NA NA hsa-miR-320c SYT11 -0.634817265516566 0.0229406911033521 0.0185524071818368 0.97222975992549 miRanda;mirMAP;miRNATAP -0.139976912479878 0.0284762800057772 NA NA NA hsa-miR-1275 TACR1 -0.092958576443477 0.78712696322568 -0.134953733071255 0.796491756882485 MirTarget -0.380126690762765 2.75064734177694e-05 NA NA NA hsa-miR-1275 TAGLN -0.092958576443477 0.78712696322568 0.260590227906576 0.823061420414032 MirTarget -0.328971717088481 8.13031830761381e-07 NA NA NA hsa-miR-222-3p TAOK1 0.067264556454159 0.934147523407911 -0.326984533068038 0.548112365432775 miRNATAP -0.268161371743201 2.59590762543185e-05 NA NA NA hsa-miR-100-5p TAPBP -0.0835426508859793 0.958163253942357 -0.00832998956892972 0.994206324623242 miRNAWalker2_validate -0.141970376529119 5.86763535838069e-05 NA NA NA hsa-miR-143-3p TBC1D15 -0.0402404826858778 0.987317207979986 -0.0463602073339286 0.950878032038645 MirTarget -0.101599131643946 0.00038749088016282 NA NA NA hsa-miR-451a TBX1 -0.150707356551769 0.885791087039658 -0.138535396130428 0.755217666813132 MirTarget -0.249935755058081 0.000526571009218758 NA NA NA hsa-miR-320c TCEAL2 -0.634817265516566 0.0229406911033521 -0.095305325510787 0.873149206530859 miRanda -0.294821955155313 0.0345196518882768 NA NA NA hsa-miR-222-3p TCF4 0.067264556454159 0.934147523407911 -0.11908642965175 0.863101489058132 miRNATAP -0.630347319107329 2.74020133851809e-16 NA NA NA hsa-miR-100-5p TCP1 -0.0835426508859793 0.958163253942357 0.0203887393472595 0.985533657560689 miRNAWalker2_validate -0.136743664537874 6.01369028579366e-08 NA NA NA hsa-miR-1275 TCP11L1 -0.092958576443477 0.78712696322568 -0.0954997960994897 0.811881069390544 MirTarget -0.11165116772225 5.07825789932573e-08 NA NA NA hsa-miR-125b-5p TDG 0.00744496603712985 0.994576506820994 -0.00782627464007302 0.990619760746948 miRNAWalker2_validate;miRNATAP -0.11454650298591 9.63531795751472e-07 NA NA NA hsa-miR-320c TDO2 -0.634817265516566 0.0229406911033521 -0.0402082284293883 0.921592829755925 miRanda -0.211990473235697 0.0210609687385707 NA NA NA hsa-miR-100-5p TEX264 -0.0835426508859793 0.958163253942357 0.0217140414692478 0.979978327669552 miRNAWalker2_validate -0.105684113573798 2.62757145978637e-05 NA NA NA hsa-miR-10a-5p TFAP2C -0.103091346403293 0.963361104257071 0.0492665020658678 0.912020918966296 miRNAWalker2_validate;MirTarget;miRNATAP -0.270768198443219 0.0368475402950204 NA NA NA hsa-miR-10a-5p TGFB3 -0.103091346403293 0.963361104257071 0.226150981324287 0.680893976927359 miRNAWalker2_validate -0.598760473914115 1.53805553632417e-08 NA NA NA hsa-miR-320c THBS2 -0.634817265516566 0.0229406911033521 0.405972537052076 0.690250248202443 mirMAP -0.25460060672415 0.0264694710931816 NA NA NA hsa-miR-320c THBS4 -0.634817265516566 0.0229406911033521 -0.0588864404879156 0.936763983770927 miRanda -0.49308560539857 0.0137932188231582 NA NA NA hsa-miR-125b-5p THUMPD3 0.00744496603712985 0.994576506820994 -0.145103981553899 0.852683329924943 miRNAWalker2_validate -0.101714263273645 4.2034750700971e-05 NA NA NA hsa-miR-10a-5p TIAM1 -0.103091346403293 0.963361104257071 -0.0134100944191435 0.971135594124117 MirTarget;miRNATAP -0.263662903922749 0.0106586905148938 26870215 Expression of microRNA 10a microRNA 342 3p and their predicted target gene TIAM1 in extranodal NK/T cell lymphoma nasal type; In the present study the association between the expression levels of miR-10a and miR-342-3p and the protein expression levels of TIAM1 was examined in ENKTCL tissues lymphoma hsa-miR-1275 TIE1 -0.092958576443477 0.78712696322568 0.172565070260989 0.761154214737108 MirTarget -0.230972793206535 3.69674816074268e-07 NA NA NA hsa-miR-143-3p TIGD5 -0.0402404826858778 0.987317207979986 -0.160091088178418 0.765566011467222 MirTarget -0.105154111818434 0.0377150975099902 NA NA NA hsa-miR-320c TIMP2 -0.634817265516566 0.0229406911033521 0.061410026250285 0.95639908183492 mirMAP -0.142657246131077 0.036985867108905 NA NA NA hsa-miR-222-3p TIMP3 0.067264556454159 0.934147523407911 -0.0611268188267431 0.955986876746131 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.496033918657858 1.3580657672408e-06 NA NA NA hsa-miR-222-3p TLN1 0.067264556454159 0.934147523407911 -0.0532369240658248 0.964418768044479 miRNAWalker2_validate -0.224543584852925 1.92786104663273e-08 NA NA NA hsa-miR-103a-3p TMEM100 -0.0950237190031995 0.961005442872667 -0.168035391477175 0.684763754563561 miRNAWalker2_validate -0.75050674905545 0.000124610755002757 NA NA NA hsa-miR-107 TMEM100 -0.0692564691973274 0.964215554949362 -0.168035391477175 0.684763754563561 miRanda -0.95836509228029 1.69690473239226e-05 NA NA NA hsa-miR-1262 TMEM100 -0.0365609639451277 0.873061890079863 -0.168035391477175 0.684763754563561 MirTarget -0.252587929479003 0.046236253173926 NA NA NA hsa-miR-15a-5p TMEM100 0.114954548711096 0.902368422572956 -0.168035391477175 0.684763754563561 MirTarget -1.15559267168091 3.6279145703148e-14 NA NA NA hsa-miR-15b-5p TMEM100 -0.00689607878522391 0.994628523271082 -0.168035391477175 0.684763754563561 MirTarget -1.00769081200355 3.22303014683036e-12 NA NA NA hsa-miR-16-5p TMEM100 0.174671689106251 0.884561260745118 -0.168035391477175 0.684763754563561 miRNAWalker2_validate;MirTarget -1.09119399508031 2.00011031994845e-14 NA NA NA hsa-miR-17-5p TMEM100 0.0171021356945324 0.989602604642911 -0.168035391477175 0.684763754563561 TargetScan -0.942379919483843 4.3583956640927e-18 NA NA NA hsa-miR-203a-3p TMEM100 -0.206623177096338 0.913514558057418 -0.168035391477175 0.684763754563561 MirTarget -0.587251001586166 1.13721788613091e-09 NA NA NA hsa-miR-30d-3p TMEM100 -0.0335580902863248 0.922063545694521 -0.168035391477175 0.684763754563561 MirTarget -0.937856253330572 6.10115546304416e-11 NA NA NA hsa-miR-320a TMEM100 -0.107569150746519 0.931865460967284 -0.168035391477175 0.684763754563561 MirTarget;miRanda -0.517257440073031 0.0011434810922461 NA NA NA hsa-miR-320b TMEM100 -0.0277181860624873 0.972824658201018 -0.168035391477175 0.684763754563561 MirTarget;miRanda -0.377528958884173 0.00846558773383882 NA NA NA hsa-miR-374a-5p TMEM100 -0.22568107720489 0.754040348516339 -0.168035391477175 0.684763754563561 mirMAP -0.616532753046613 0.00124516568596716 NA NA NA hsa-miR-374b-3p TMEM100 -0.0786253775219115 0.722308239126602 -0.168035391477175 0.684763754563561 MirTarget -0.743297733017452 2.56156487393231e-07 NA NA NA hsa-miR-374b-5p TMEM100 -0.266960088707788 0.755383602539075 -0.168035391477175 0.684763754563561 mirMAP -0.774089975661274 2.48806684229936e-05 NA NA NA hsa-miR-378a-5p TMEM100 0.0169466557854978 0.986000148044016 -0.168035391477175 0.684763754563561 MirTarget -0.696071812695965 1.85609422652216e-07 NA NA NA hsa-miR-421 TMEM100 -0.226934983690969 0.526580030309737 -0.168035391477175 0.684763754563561 miRanda -0.570919411424074 6.23201263071094e-06 NA NA NA hsa-miR-424-5p TMEM100 0.146526105979442 0.876616075168222 -0.168035391477175 0.684763754563561 MirTarget -0.529737985177608 1.45268512964959e-06 NA NA NA hsa-miR-429 TMEM100 -0.238887571847831 0.835358736540541 -0.168035391477175 0.684763754563561 miRanda -0.852194230062856 4.0087450458605e-18 NA NA NA hsa-miR-501-5p TMEM100 -0.103468262663096 0.736253638346517 -0.168035391477175 0.684763754563561 MirTarget -0.507947318463618 1.795892045504e-07 NA NA NA hsa-miR-532-3p TMEM100 -0.00929099998528304 0.99000386705064 -0.168035391477175 0.684763754563561 MirTarget -0.792914362986911 6.24033554012273e-12 NA NA NA hsa-miR-577 TMEM100 -0.709022386979996 0.309866560581154 -0.168035391477175 0.684763754563561 PITA -0.55916732415342 4.83705559273324e-18 NA NA NA hsa-miR-590-3p TMEM100 0.0829620326684548 0.810708708264937 -0.168035391477175 0.684763754563561 miRanda -0.77514120550556 2.87356788341433e-13 NA NA NA hsa-miR-93-5p TMEM100 -0.093851027778495 0.955646810234554 -0.168035391477175 0.684763754563561 miRNAWalker2_validate -1.08440440141249 2.06143938497814e-15 NA NA NA hsa-miR-1275 TMEM106A -0.092958576443477 0.78712696322568 -0.0927813263636497 0.779715042640194 MirTarget -0.145869412213832 0.00330416553614499 NA NA NA hsa-miR-320c TMEM108 -0.634817265516566 0.0229406911033521 -0.0411920684166518 0.900039613454674 MirTarget;PITA;miRanda;miRNATAP -0.149810460963884 0.0245654160388131 NA NA NA hsa-miR-1275 TMEM119 -0.092958576443477 0.78712696322568 -0.233826481805887 0.706589279553959 MirTarget -0.12798026828931 0.0276177939036933 NA NA NA hsa-miR-10a-5p TMEM132A -0.103091346403293 0.963361104257071 0.021750692261528 0.977135865633203 mirMAP -0.172575194968489 0.00390286021934981 NA NA NA hsa-miR-320c TMEM132C -0.634817265516566 0.0229406911033521 0.400016280350883 0.525650400814438 miRanda -0.330115829756725 0.024440103921384 NA NA NA hsa-miR-125b-5p TMEM161B 0.00744496603712985 0.994576506820994 0.182122778272389 0.733350838435058 MirTarget;miRNATAP -0.142900078647041 8.98245308503822e-07 NA NA NA hsa-miR-10a-5p TMEM170B -0.103091346403293 0.963361104257071 -0.022205698812324 0.955783550275804 MirTarget;miRNATAP -0.199496728413606 0.0152525448007763 NA NA NA hsa-miR-222-3p TMEM25 0.067264556454159 0.934147523407911 -0.422320826327073 0.246149246808192 MirTarget -0.278708934923064 0.00850191180860747 NA NA NA hsa-miR-1275 TMEM26 -0.092958576443477 0.78712696322568 0.00952564409946122 0.966535241215577 MirTarget -0.163010019359663 0.000290658157840544 NA NA NA hsa-miR-320c TMEM26 -0.634817265516566 0.0229406911033521 0.00952564409946122 0.966535241215577 miRanda -0.149297436066055 0.0087198957826885 NA NA NA hsa-miR-143-3p TMEM33 -0.0402404826858778 0.987317207979986 0.0212388684332616 0.981697234801606 MirTarget -0.126547782262398 0.00109191614786807 NA NA NA hsa-miR-320c TMEM47 -0.634817265516566 0.0229406911033521 0.0953333453344878 0.866672754170938 MirTarget;PITA;miRanda;miRNATAP -0.182143957828607 0.00849026764973864 NA NA NA hsa-miR-143-3p TMEM69 -0.0402404826858778 0.987317207979986 -0.0920732238008952 0.891826195325041 MirTarget -0.112567639097956 0.00354215917460501 NA NA NA hsa-miR-10a-5p TMOD1 -0.103091346403293 0.963361104257071 0.125298684415789 0.751845915378068 miRNATAP -0.184620222371025 0.0105238311205852 NA NA NA hsa-miR-1266-5p TMOD1 -0.266145615222676 0.680163986604976 0.125298684415789 0.751845915378068 MirTarget -0.190576823569721 0.000439152728909381 NA NA NA hsa-miR-1301-3p TMOD1 -0.0780897020985147 0.826253480527259 0.125298684415789 0.751845915378068 MirTarget -0.220162128599944 0.00448104909459563 NA NA NA hsa-miR-182-5p TMOD1 -0.152479992183316 0.936904765738824 0.125298684415789 0.751845915378068 miRNATAP -0.2001968861105 0.00248800202446643 NA NA NA hsa-miR-186-5p TMOD1 -0.103524789975763 0.922074318057442 0.125298684415789 0.751845915378068 miRNATAP -0.632138660960128 5.87725407622361e-10 NA NA NA hsa-miR-219a-1-3p TMOD1 -0.442728245322625 0.115524689470187 0.125298684415789 0.751845915378068 MirTarget -0.332283169529509 4.08371580520723e-08 NA NA NA hsa-miR-221-5p TMOD1 0.274700984250903 0.491832475464702 0.125298684415789 0.751845915378068 MirTarget -0.1473326214782 0.00822011598650485 NA NA NA hsa-miR-23a-3p TMOD1 -0.0188223454559413 0.990631768418334 0.125298684415789 0.751845915378068 MirTarget;miRNATAP -0.838813165727848 4.81440123041026e-10 NA NA NA hsa-miR-30e-3p TMOD1 -0.0945081226096836 0.957075120225909 0.125298684415789 0.751845915378068 mirMAP -0.650744008485584 1.68775860682471e-06 NA NA NA hsa-miR-335-3p TMOD1 -0.169930485068435 0.871151368030036 0.125298684415789 0.751845915378068 mirMAP -0.50584685489773 5.09277083419352e-15 NA NA NA hsa-miR-338-3p TMOD1 0.255396056124829 0.823521689335585 0.125298684415789 0.751845915378068 miRanda -0.134540722184192 0.0163611470395971 NA NA NA hsa-miR-421 TMOD1 -0.226934983690969 0.526580030309737 0.125298684415789 0.751845915378068 miRanda -0.230567743105103 0.00132434948482715 NA NA NA hsa-miR-429 TMOD1 -0.238887571847831 0.835358736540541 0.125298684415789 0.751845915378068 miRanda;miRNATAP -0.341660004502787 3.11705584495603e-09 NA NA NA hsa-miR-486-5p TMOD1 -0.16110372776006 0.851150395551866 0.125298684415789 0.751845915378068 miRanda;miRNATAP -0.109052026600697 0.0316375955438164 NA NA NA hsa-miR-744-3p TMOD1 -0.100810603563841 0.833454142252121 0.125298684415789 0.751845915378068 MirTarget -0.307366230168763 4.58812684892929e-06 NA NA NA hsa-miR-96-5p TMOD1 0.0812346609576227 0.885285229701925 0.125298684415789 0.751845915378068 miRNATAP -0.168477368571819 0.00906377768347802 NA NA NA hsa-miR-320c TMSB15B -0.634817265516566 0.0229406911033521 0.253373180484213 0.44241548557036 miRanda -0.175785746826077 0.0465519485675631 NA NA NA hsa-miR-1275 TNFAIP2 -0.092958576443477 0.78712696322568 0.167166338267473 0.822966074118731 MirTarget -0.152930158299979 0.00351524783418606 NA NA NA hsa-miR-143-3p TNFRSF11A -0.0402404826858778 0.987317207979986 -0.101256240385372 0.865930932088691 mirMAP -0.282644549860184 0.00722559840708128 NA NA NA hsa-miR-320c TNFRSF9 -0.634817265516566 0.0229406911033521 -0.00628573496683354 0.985043520816412 miRanda -0.1834964463161 0.0327241331530536 NA NA NA hsa-miR-1275 TNFSF12 -0.092958576443477 0.78712696322568 -0.00995968730929597 0.985463669582788 MirTarget -0.152130747266792 6.40190856990028e-05 NA NA NA hsa-miR-320c TNS1 -0.634817265516566 0.0229406911033521 -0.0852174376184625 0.928021624667819 MirTarget;miRanda -0.169385923360898 0.0436715495682655 NA NA NA hsa-miR-125b-5p TOMM40 0.00744496603712985 0.994576506820994 0.0779232058505643 0.934231035138806 mirMAP -0.124264123681689 2.85077315682224e-05 NA NA NA hsa-miR-125b-5p TOR2A 0.00744496603712985 0.994576506820994 0.0774207833479359 0.904507692062628 MirTarget;miRNATAP -0.113626129941626 5.2871756865126e-05 NA NA NA hsa-miR-143-3p TOR2A -0.0402404826858778 0.987317207979986 0.0774207833479359 0.904507692062628 mirMAP -0.19311987392177 1.10295542014737e-06 NA NA NA hsa-miR-222-3p TOX 0.067264556454159 0.934147523407911 -0.107131506246827 0.82507299431856 MirTarget;miRNATAP -0.538162283827882 4.61176251593421e-05 NA NA NA hsa-miR-320c TPM2 -0.634817265516566 0.0229406911033521 0.410849806705547 0.684053058058986 miRanda -0.22469107778323 0.00102688214024974 NA NA NA hsa-miR-143-3p TPM3 -0.0402404826858778 0.987317207979986 0.138823104549195 0.912428861877721 miRNATAP -0.128156010005834 2.79800058987904e-05 NA NA NA hsa-miR-10a-5p TPPP -0.103091346403293 0.963361104257071 -0.0310708563473554 0.95719986688517 mirMAP -0.316574989878686 0.00214513021709426 NA NA NA hsa-miR-1275 TPPP -0.092958576443477 0.78712696322568 -0.0310708563473554 0.95719986688517 mirMAP -0.172209844188209 0.011347257521523 NA NA NA hsa-miR-320c TPST1 -0.634817265516566 0.0229406911033521 0.0426460060624914 0.918067146816977 miRanda -0.146537533286214 0.0219425980122705 NA NA NA hsa-miR-10a-5p TRAF3 -0.103091346403293 0.963361104257071 -0.0609517677173299 0.913048940484171 mirMAP -0.130176570740519 6.47917651112661e-05 NA NA NA hsa-miR-222-3p TRIM44 0.067264556454159 0.934147523407911 -0.161019592793142 0.847820578616379 miRNAWalker2_validate -0.162187596028104 6.6899154719445e-05 NA NA NA hsa-miR-1275 TRIM46 -0.092958576443477 0.78712696322568 0.209373743717142 0.368328734383762 miRNATAP -0.142781008577958 0.00243937736504664 NA NA NA hsa-miR-320c TRIM46 -0.634817265516566 0.0229406911033521 0.209373743717142 0.368328734383762 miRanda -0.138225826801002 0.0200516130805258 NA NA NA hsa-miR-320c TRIM58 -0.634817265516566 0.0229406911033521 0.56695214368469 0.302075603198824 miRanda -0.466431186815584 0.00161326347630389 NA NA NA hsa-miR-320c TRIM6 -0.634817265516566 0.0229406911033521 0.199603336522283 0.424707328775741 miRanda -0.146532244922121 0.0247336786129019 NA NA NA hsa-miR-320c TRIM9 -0.634817265516566 0.0229406911033521 0.163253156462233 0.657188335570264 miRanda -0.250839898164346 0.010125396785826 NA NA NA hsa-miR-1275 TRPS1 -0.092958576443477 0.78712696322568 0.0989070245394013 0.799651991321855 PITA -0.259884643616503 5.94710008151679e-06 NA NA NA hsa-miR-222-3p TRPS1 0.067264556454159 0.934147523407911 0.0989070245394013 0.799651991321855 miRTarBase;MirTarget;miRNATAP -0.601904235024853 1.09529856450279e-09 23776679 In breast cancer the microRNAs miRNAs miR-221 and miR-222 miR-221/222 are differentially expressed in the clinically more aggressive basal-like subtype compared to luminal subtype of breast cancer and upregulation of miR-221/222 induces the EMT by targeting the 3' untranslated region 3'UTR of the GATA family transcriptional repressor TRPS1 tricho-rhino-phalangeal syndrome type 1 breast cancer hsa-miR-125b-5p TSEN54 0.00744496603712985 0.994576506820994 0.130890602450846 0.866117656726715 MirTarget -0.112902242708798 8.44200732687111e-05 NA NA NA hsa-miR-1275 TSHZ2 -0.092958576443477 0.78712696322568 -0.238114448157475 0.532722114311747 MirTarget -0.311135429657945 0.000100605036839402 NA NA NA hsa-miR-320c TSHZ3 -0.634817265516566 0.0229406911033521 -0.113316280445519 0.790417979852769 MirTarget;PITA;miRanda;miRNATAP -0.144633124279064 0.0287469076200463 NA NA NA hsa-miR-125b-5p TSPAN12 0.00744496603712985 0.994576506820994 -0.297769384928304 0.692987776823451 miRNATAP -0.118501343109972 0.0212946017202701 NA NA NA hsa-miR-143-3p TSPAN13 -0.0402404826858778 0.987317207979986 -0.173681023973715 0.858830292975206 miRNATAP -0.20862040250171 0.0056262784498944 NA NA NA hsa-miR-1275 TSPAN18 -0.092958576443477 0.78712696322568 0.157473856060396 0.778273229446917 MirTarget -0.137276410640041 0.00934204917860503 NA NA NA hsa-miR-320c TSPYL5 -0.634817265516566 0.0229406911033521 0.0412641179884607 0.909132635467883 MirTarget;miRNATAP -0.175604109502662 0.0119382995376923 NA NA NA hsa-miR-10a-5p TTC7A -0.103091346403293 0.963361104257071 -0.0167858718055349 0.982533395745051 miRNAWalker2_validate -0.110480698777331 0.00370632808789871 NA NA NA hsa-miR-1275 TTLL6 -0.092958576443477 0.78712696322568 -0.510332998873486 0.136554574475661 MirTarget -0.147980722918325 0.0434268527080114 NA NA NA hsa-miR-1275 TUB -0.092958576443477 0.78712696322568 -0.00586110467341801 0.985745103204302 MirTarget -0.20774914318457 0.00255316578460818 NA NA NA hsa-miR-222-3p TUB 0.067264556454159 0.934147523407911 -0.00586110467341801 0.985745103204302 MirTarget -0.733312781251313 3.26471353101198e-10 NA NA NA hsa-miR-320c TUB -0.634817265516566 0.0229406911033521 -0.00586110467341801 0.985745103204302 mirMAP -0.221655260290567 0.0106301062944428 NA NA NA hsa-miR-10a-5p TUBA1A -0.103091346403293 0.963361104257071 0.121459498351726 0.900108148802669 miRNAWalker2_validate -0.199291631654622 3.97303733748215e-05 NA NA NA hsa-miR-222-3p TUBA1A 0.067264556454159 0.934147523407911 0.121459498351726 0.900108148802669 MirTarget -0.313330450407649 1.1516144907717e-08 NA NA NA hsa-miR-320c TUBB6 -0.634817265516566 0.0229406911033521 0.267872030932212 0.725033349968471 miRanda -0.124900268303074 0.00314061108762311 NA NA NA hsa-miR-125b-5p TUBG1 0.00744496603712985 0.994576506820994 0.0766127309754845 0.92549210438012 miRNATAP -0.128067293788734 8.8609608846888e-06 NA NA NA hsa-miR-320c TUSC3 -0.634817265516566 0.0229406911033521 0.000390113411403492 0.999190131676102 MirTarget;miRanda -0.157751886709822 0.0243680532440696 NA NA NA hsa-miR-1275 TXK -0.092958576443477 0.78712696322568 -0.199384538725972 0.497993447171616 MirTarget -0.113247518241636 0.0151088872286843 NA NA NA hsa-let-7f-2-3p TXLNB 0.238941477392834 0.315760779195886 -0.324301795692796 0.329541392599768 MirTarget -0.279317026265435 0.00141605204640245 NA NA NA hsa-miR-200a-5p TXLNB -0.0789456056445115 0.956935767371258 -0.324301795692796 0.329541392599768 MirTarget -0.614896880086033 6.03526236641897e-12 NA NA NA hsa-miR-200b-5p TXLNB -0.0843746780836296 0.921517885377118 -0.324301795692796 0.329541392599768 MirTarget -0.633184016571618 6.23464232019374e-13 NA NA NA hsa-miR-30d-3p TXLNB -0.0335580902863248 0.922063545694521 -0.324301795692796 0.329541392599768 MirTarget -0.475637965599627 2.22981941893699e-05 NA NA NA hsa-miR-30e-3p TXLNB -0.0945081226096836 0.957075120225909 -0.324301795692796 0.329541392599768 MirTarget -0.38886005393636 0.0385985077997238 NA NA NA hsa-miR-330-3p TXLNB -0.0147414471416165 0.959553964589524 -0.324301795692796 0.329541392599768 miRNATAP -0.244534686984463 0.0288077949248801 NA NA NA hsa-miR-33a-3p TXLNB -0.478382609529613 0.0473796525588213 -0.324301795692796 0.329541392599768 mirMAP -0.448440880292401 1.02286191156935e-07 NA NA NA hsa-miR-374b-5p TXLNB -0.266960088707788 0.755383602539075 -0.324301795692796 0.329541392599768 MirTarget -0.356118609724238 0.0118674870164901 NA NA NA hsa-miR-532-5p TXLNB -0.0433373569664539 0.975398214701797 -0.324301795692796 0.329541392599768 MirTarget -0.308982434278686 0.00235173762353619 NA NA NA hsa-miR-584-5p TXLNB -0.161825173854309 0.888884520738016 -0.324301795692796 0.329541392599768 mirMAP -0.27754880734085 3.59404359901285e-05 NA NA NA hsa-miR-590-3p TXLNB 0.0829620326684548 0.810708708264937 -0.324301795692796 0.329541392599768 MirTarget;PITA;miRanda;mirMAP -0.490658148643595 2.61185462355838e-09 NA NA NA hsa-miR-7-1-3p TXLNB -0.126737838158129 0.846416009084243 -0.324301795692796 0.329541392599768 MirTarget -0.577448331666109 2.19597421214342e-09 NA NA NA hsa-miR-744-3p TXLNB -0.100810603563841 0.833454142252121 -0.324301795692796 0.329541392599768 MirTarget -0.458581845078037 3.85294968857327e-07 NA NA NA hsa-miR-125b-5p TXNRD1 0.00744496603712985 0.994576506820994 -0.0161692188648583 0.987204049356228 MirTarget;miRNATAP -0.108406210015456 1.01142298606544e-05 NA NA NA hsa-miR-125b-5p UBA6 0.00744496603712985 0.994576506820994 0.0273150751323028 0.972617005042272 miRNAWalker2_validate -0.115155460804449 3.90403457910963e-06 NA NA NA hsa-miR-125b-5p UBR7 0.00744496603712985 0.994576506820994 0.00709733876290475 0.992594351306892 miRNATAP -0.106944320087711 9.45041475534964e-07 NA NA NA hsa-miR-1275 UNC13A -0.092958576443477 0.78712696322568 -0.362818581578493 0.303358778684592 MirTarget -0.185906003211068 0.0130260067882849 NA NA NA hsa-miR-125b-5p UNG 0.00744496603712985 0.994576506820994 -0.107303813622648 0.901704090273906 miRNAWalker2_validate -0.111050862960616 6.99650733623484e-05 NA NA NA hsa-miR-100-5p USP1 -0.0835426508859793 0.958163253942357 -0.214982097161697 0.79677168413462 miRNAWalker2_validate -0.122901184048499 7.14426074513768e-07 NA NA NA hsa-miR-10a-5p USP11 -0.103091346403293 0.963361104257071 -0.182238105937926 0.828320718180879 miRNAWalker2_validate -0.103671527145275 0.00651082124265901 NA NA NA hsa-miR-125b-5p USP38 0.00744496603712985 0.994576506820994 -0.192924416880862 0.796709801534204 miRNATAP -0.105633828713342 1.81165544329911e-05 NA NA NA hsa-miR-143-3p USP45 -0.0402404826858778 0.987317207979986 -0.00261968168008364 0.995800153863131 miRNATAP -0.106985703090619 0.00215428472190605 NA NA NA hsa-miR-1275 UST -0.092958576443477 0.78712696322568 0.0559880710207845 0.876994251723676 MirTarget -0.291845962982214 7.91759736745465e-05 NA NA NA hsa-miR-222-3p VASH1 0.067264556454159 0.934147523407911 0.0951603661026663 0.877793262441773 MirTarget;miRNATAP -0.391999501337199 1.54888218177456e-08 NA NA NA hsa-miR-320c VASH1 -0.634817265516566 0.0229406911033521 0.0951603661026663 0.877793262441773 mirMAP -0.10604545988721 0.038513508802063 NA NA NA hsa-miR-320c VASH2 -0.634817265516566 0.0229406911033521 0.193641534075681 0.521008698365727 miRanda -0.121800212524982 0.0455166743691402 NA NA NA hsa-miR-1275 VAT1L -0.092958576443477 0.78712696322568 -0.416572404765013 0.178223382441409 MirTarget -0.143598564699106 0.0215832848279313 NA NA NA hsa-miR-222-3p VCL 0.067264556454159 0.934147523407911 -0.0348563791020879 0.974117147314461 miRNAWalker2_validate -0.238719640152201 2.15755932039058e-08 NA NA NA hsa-miR-1275 VEPH1 -0.092958576443477 0.78712696322568 0.551118413038404 0.222697200013733 MirTarget -0.183305968031927 0.00927038353778684 NA NA NA hsa-miR-320c VGLL3 -0.634817265516566 0.0229406911033521 0.200455670629468 0.654467878056983 miRNATAP -0.182734427626836 0.0412602872419777 NA NA NA hsa-miR-143-3p VHL -0.0402404826858778 0.987317207979986 -0.158395601294997 0.83053447137284 MirTarget -0.161135116764003 4.66630949439722e-08 NA NA NA hsa-miR-320c VIM -0.634817265516566 0.0229406911033521 0.182948632974135 0.879963955135144 PITA;miRanda;miRNATAP -0.145449389104665 0.0113465068416254 NA NA NA hsa-miR-451a VIPR2 -0.150707356551769 0.885791087039658 -0.418001965905114 0.314908311046302 mirMAP -0.420743402746041 4.30331505593437e-06 NA NA NA hsa-miR-125b-5p VPS4B 0.00744496603712985 0.994576506820994 -0.125957716336809 0.880436648612301 MirTarget;miRNATAP -0.132976078366592 5.44052569686746e-06 NA NA NA hsa-miR-100-5p WDR4 -0.0835426508859793 0.958163253942357 -0.119538110008483 0.845532882253379 miRNAWalker2_validate -0.108025028191597 0.00212303808417023 NA NA NA hsa-miR-222-3p WDR47 0.067264556454159 0.934147523407911 -0.0284657840740077 0.952633750599349 MirTarget;miRNATAP -0.125130667434052 0.000243057769644455 NA NA NA hsa-miR-1275 WNT7B -0.092958576443477 0.78712696322568 0.329846640644057 0.461992864000436 MirTarget -0.387011416230313 3.97032686658408e-05 NA NA NA hsa-miR-1275 WSCD2 -0.092958576443477 0.78712696322568 -0.102567334864714 0.85399508485503 MirTarget -0.416752715653441 1.25521900653731e-05 NA NA NA hsa-miR-320c WTIP -0.634817265516566 0.0229406911033521 0.107495425097089 0.756631278255679 mirMAP -0.165980547835827 0.00471001848953879 NA NA NA hsa-miR-320c XIRP1 -0.634817265516566 0.0229406911033521 0.460574952176886 0.295117463526556 miRanda -0.265675973600443 0.0125707304909336 NA NA NA hsa-miR-143-3p XK -0.0402404826858778 0.987317207979986 -0.250252276443925 0.72027219793361 MirTarget -0.226564465956962 0.00371517674095125 NA NA NA hsa-miR-125b-5p XRCC3 0.00744496603712985 0.994576506820994 0.157613541175901 0.806727910447864 mirMAP -0.187346984432342 1.6814693818737e-06 NA NA NA hsa-miR-125b-5p YES1 0.00744496603712985 0.994576506820994 -0.218380133159821 0.797391237762045 miRNATAP -0.130548941687429 3.05308831634794e-06 NA NA NA hsa-miR-222-3p YLPM1 0.067264556454159 0.934147523407911 -0.177419574507551 0.838258716906693 miRNAWalker2_validate -0.13781609049147 9.21999708658745e-05 NA NA NA hsa-miR-125b-5p YOD1 0.00744496603712985 0.994576506820994 0.185924172948827 0.743105308853825 miRNATAP -0.117343435415138 9.59702115112285e-05 NA NA NA hsa-miR-100-5p YWHAE -0.0835426508859793 0.958163253942357 -0.023671892526858 0.985047609623721 miRNAWalker2_validate -0.120562901672456 8.58625884415223e-06 NA NA NA hsa-miR-100-5p ZADH2 -0.0835426508859793 0.958163253942357 -0.148437800876666 0.840128022851134 MirTarget -0.104506925072351 0.000331838556504525 NA NA NA hsa-miR-1275 ZBTB46 -0.092958576443477 0.78712696322568 0.0462417036371512 0.894794555098846 mirMAP -0.149882711073361 0.000369781545268339 NA NA NA hsa-miR-10a-5p ZBTB47 -0.103091346403293 0.963361104257071 -0.0259268501071093 0.961350108889688 mirMAP -0.254893444648927 6.65097883938134e-08 NA NA NA hsa-miR-222-3p ZC3H13 0.067264556454159 0.934147523407911 -0.0719713049978656 0.938122857122626 MirTarget -0.13818463698093 0.00177438189500702 NA NA NA hsa-miR-320c ZCCHC12 -0.634817265516566 0.0229406911033521 0.0568422498565071 0.88713537618557 miRanda -0.179280069974884 0.0172087302157808 NA NA NA hsa-miR-1275 ZDHHC15 -0.092958576443477 0.78712696322568 -0.334468770186629 0.401393109732429 MirTarget -0.185628262044961 0.00679562100415715 NA NA NA hsa-miR-143-3p ZDHHC23 -0.0402404826858778 0.987317207979986 -0.118456589139204 0.848527451351387 MirTarget -0.159975364673113 0.00468935122158958 NA NA NA hsa-miR-320c ZEB1 -0.634817265516566 0.0229406911033521 -0.104804988844125 0.864276601678338 miRanda -0.152725964150693 0.0150795673510305 NA NA NA hsa-miR-222-3p ZEB2 0.067264556454159 0.934147523407911 -0.0192263708779326 0.97472953284183 MirTarget;miRNATAP -0.581415478194843 1.29715308230558e-10 NA NA NA hsa-miR-222-3p ZFHX3 0.067264556454159 0.934147523407911 -0.332552936663988 0.651903822299263 miRNATAP -0.273683679929784 6.08246230539607e-07 NA NA NA hsa-miR-222-3p ZFPM2 0.067264556454159 0.934147523407911 0.291427952979832 0.373482799084019 miRNATAP -0.689088795280179 1.91428199383268e-09 NA NA NA hsa-miR-320c ZFPM2 -0.634817265516566 0.0229406911033521 0.291427952979832 0.373482799084019 miRanda -0.21911001254615 0.00995046833642022 NA NA NA hsa-miR-222-3p ZFYVE16 0.067264556454159 0.934147523407911 0.0804902707126427 0.910941486760428 miRNAWalker2_validate;MirTarget -0.108351981711854 0.00100891007570418 NA NA NA hsa-miR-10a-5p ZHX3 -0.103091346403293 0.963361104257071 -0.0353529787646307 0.961684981207572 mirMAP -0.175304784439827 5.82364566979278e-05 NA NA NA hsa-miR-222-3p ZMYND11 0.067264556454159 0.934147523407911 -0.100887068913837 0.907044193378594 miRNAWalker2_validate -0.11598493130248 3.07315078601661e-05 NA NA NA hsa-miR-320c ZNF229 -0.634817265516566 0.0229406911033521 0.302038806626251 0.39763245735562 miRanda -0.231668543905471 0.00376312400940252 NA NA NA hsa-miR-320c ZNF287 -0.634817265516566 0.0229406911033521 0.0573671729757396 0.832899208129875 miRanda -0.204259276319307 0.00277661914400837 NA NA NA hsa-miR-1275 ZNF385A -0.092958576443477 0.78712696322568 0.117375598848808 0.834557209067332 MirTarget;mirMAP -0.214790083924955 2.02380745484352e-05 NA NA NA hsa-miR-1275 ZNF385B -0.092958576443477 0.78712696322568 0.295249316931005 0.588273960278374 MirTarget -0.285680673226595 0.000804214422254878 NA NA NA hsa-miR-320c ZNF385B -0.634817265516566 0.0229406911033521 0.295249316931005 0.588273960278374 miRanda -0.237650525585855 0.0275940390856776 NA NA NA hsa-miR-10a-5p ZNF43 -0.103091346403293 0.963361104257071 0.0510889063224877 0.914761559262826 MirTarget -0.34014677983767 0.00791174273664597 NA NA NA hsa-miR-125b-5p ZNF460 0.00744496603712985 0.994576506820994 0.0250486498661279 0.868394000972359 miRNATAP -0.127476838448545 0.000214270525704731 NA NA NA hsa-miR-10a-5p ZNF492 -0.103091346403293 0.963361104257071 0.140712744558249 0.849802079959956 MirTarget -0.428760568689207 0.00150370260989382 NA NA NA hsa-miR-100-5p ZNF511 -0.0835426508859793 0.958163253942357 0.278806056513472 0.728692181636306 miRNAWalker2_validate -0.170814278453814 3.33514000010169e-05 NA NA NA hsa-miR-320c ZNF532 -0.634817265516566 0.0229406911033521 -0.0190408242138371 0.97706655677894 miRanda -0.110676753053035 0.044687789033484 NA NA NA hsa-miR-320c ZNF570 -0.634817265516566 0.0229406911033521 0.494047867095432 0.110473733997698 miRanda -0.169207174804138 0.0411125101630581 NA NA NA hsa-miR-222-3p ZNF615 0.067264556454159 0.934147523407911 -0.267596834849121 0.497959594584367 MirTarget -0.15056263657223 0.0355965143928812 NA NA NA hsa-miR-320c ZNF615 -0.634817265516566 0.0229406911033521 -0.267596834849121 0.497959594584367 miRanda -0.141610344935938 0.00563518788285081 NA NA NA hsa-miR-1275 ZNF618 -0.092958576443477 0.78712696322568 0.36458321739569 0.503439788724443 mirMAP -0.167529030865669 0.00161462843301561 NA NA NA hsa-miR-320c ZNF626 -0.634817265516566 0.0229406911033521 0.0655288773050837 0.809149524864806 miRanda -0.178307640493972 0.00998693231860945 NA NA NA hsa-miR-320c ZNF671 -0.634817265516566 0.0229406911033521 0.245305566528436 0.29886713426318 miRanda -0.191342963380791 0.00175087019547038 NA NA NA hsa-miR-222-3p ZNF677 0.067264556454159 0.934147523407911 -0.218265859132458 0.588874948884276 mirMAP -0.627404505390991 2.72643845295512e-09 NA NA NA hsa-miR-222-3p ZNF704 0.067264556454159 0.934147523407911 -0.604734891864468 0.188630770373455 miRNATAP -0.424602007526005 6.974795590786e-07 NA NA NA hsa-miR-222-3p ZNF772 0.067264556454159 0.934147523407911 -0.119144963375003 0.709940498496005 miRNAWalker2_validate -0.501701275942003 1.8665545094953e-05 NA NA NA hsa-miR-143-3p ZWILCH -0.0402404826858778 0.987317207979986 -0.0675585380910499 0.920047839239592 MirTarget -0.174985623009447 9.33116324383395e-05 NA NA NA